WorldWideScience

Sample records for sunwise action steps

  1. COMMUNITY-BASED UV RISK EDUCATION: THE SUNWISE PROGRAM HANDBOOK

    Science.gov (United States)

    This handbook is a user-friendly "How-to Guide" on providing information on how the SunWise project: 1) increased understanding of the importance of Ultraviolet light as a carcinogenic agent and an agent of skin aging, 2) disseminated time-relevant information on when (times of d...

  2. The SunWise Policy Intervention for School-Based Sun Protection: A Pilot Study

    Science.gov (United States)

    Emmons, Karen M.; Geller, Alan C.; Viswanath, Vish; Rutsch, Linda; Zwirn, Jodie; Gorham, Sue; Puleo, Elaine

    2008-01-01

    Skin cancer is highly preventable, but clearly there is a critical need to focus on better ways to disseminate information about known skin cancer prevention. The U.S. Environmental Protection Agency's (EPA) SunWise Program is one channel for reaching children, teachers, and school nurses. In a pilot study designed to increase adoption of…

  3. Action research: A practical step-by-step guide for Agricultural ...

    African Journals Online (AJOL)

    Based on the findings, the extensionists will be able to identify the action required to improve upon the existing situation. This calls for knowledge and skills in action oriented research. This paper provides simple, easy to follow, step-by-step guidelines which should be suitable for many situations in extension research ...

  4. Can an hour or two of sun protection education keep the sunburn away? Evaluation of the Environmental Protection Agency's Sunwise School Program

    Directory of Open Access Journals (Sweden)

    Kenausis Kristin

    2003-11-01

    Full Text Available Abstract Background Melanoma incidence is rising at a rate faster than any other preventable cancer in the United States. Childhood exposure to ultraviolet (UV light increases risk for skin cancer as an adult, thus starting positive sun protection habits early may be key to reducing the incidence of this disease. Methods The Environmental Protection Agency's SunWise School Program, a national environmental and health education program for sun safety of children in primary and secondary schools (grades K-8, was evaluated with surveys administered to participating students and faculty. Results Pretests (n = 5,625 and posttests (n = 5,028 were completed by students in 102 schools in 42 states. Significant improvement was noted for the three knowledge variables. Intentions to play in the shade increased from 68% to 75%(p Conclusions Brief, standardized sun protection education can be efficiently interwoven into existing school curricula, and result in improvements in knowledge and positive intentions for sun protection.

  5. A scaling study of the step scaling function of quenched QCD with improved gauge actions

    International Nuclear Information System (INIS)

    Takeda, S.; Aoki, S.; Fukugita, M.; Ishikawa, K-I.; Ishizuka, N.; Iwasaki, Y.; Kanaya, K.; Kaneko, T.; Kuramashi, Y.; Okawa, M.; Taniguchi, Y.; Ukawa, A.; Yoshie, T.

    2005-01-01

    We study the scaling behavior of the step scaling function for SU(3) gauge theory, employing the Iwasaki gauge action and the Luescher-Weisz gauge action. In particular, we test the choice of boundary counter terms and apply a perturbative procedure for removal of lattice artifacts for the simulation results in the extrapolation procedure. We confirm the universality of the step scaling functions at both weak and strong coupling regions. We also measure the low energy scale ratio with the Iwasaki action, and confirm its universality

  6. Steps for arm and trunk actions of overhead forehand stroke used in badminton games across skill levels.

    Science.gov (United States)

    Wang, Jianyu; Liu, Wenhao; Moffit, Jeffrey

    2009-08-01

    The purpose of this study was to examine arm and trunk actions in overhead forehand strokes used in badminton games across skill levels. The participants were 80 students (40 boys, 40 girls) who were randomly selected from video recordings of 300 students ages 16 to 19 years. The videotaped performances of overhead forehand strokes were coded based on three steps of arm action (elbow flexion, elbow and humeral flexion, and upward backswing) and three steps of trunk action (no trunk action, forward-backward movement, and trunk rotation). Students across the four skill levels exhibited different patterns of arm and trunk actions. Students at advanced levels used more mature arm and trunk actions.

  7. Blueprint for action: steps toward a high-quality, high-value maternity care system.

    Science.gov (United States)

    Angood, Peter B; Armstrong, Elizabeth Mitchell; Ashton, Diane; Burstin, Helen; Corry, Maureen P; Delbanco, Suzanne F; Fildes, Barbara; Fox, Daniel M; Gluck, Paul A; Gullo, Sue Leavitt; Howes, Joanne; Jolivet, R Rima; Laube, Douglas W; Lynne, Donna; Main, Elliott; Markus, Anne Rossier; Mayberry, Linda; Mitchell, Lynn V; Ness, Debra L; Nuzum, Rachel; Quinlan, Jeffrey D; Sakala, Carol; Salganicoff, Alina

    2010-01-01

    Childbirth Connection hosted a 90th Anniversary national policy symposium, Transforming Maternity Care: A High Value Proposition, on April 3, 2009, in Washington, DC. Over 100 leaders from across the range of stakeholder perspectives were actively engaged in the symposium work to improve the quality and value of U.S. maternity care through broad system improvement. A multi-disciplinary symposium steering committee guided the strategy from its inception and contributed to every phase of the project. The "Blueprint for Action: Steps Toward a High Quality, High Value Maternity Care System", issued by the Transforming Maternity Care Symposium Steering Committee, answers the fundamental question, "Who needs to do what, to, for, and with whom to improve the quality of maternity care over the next five years?" Five stakeholder workgroups collaborated to propose actionable strategies in 11 critical focus areas for moving expeditiously toward the realization of the long term "2020 Vision for a High Quality, High Value Maternity Care System", also published in this issue. Following the symposium these workgroup reports and recommendations were synthesized into the current blueprint. For each critical focus area, the "Blueprint for Action" presents a brief problem statement, a set of system goals for improvement in that area, and major recommendations with proposed action steps to achieve them. This process created a clear sightline to action that if enacted could improve the structure, process, experiences of care, and outcomes of the maternity care system in ways that when anchored in the culture can indeed transform maternity care. Copyright 2010 Jacobs Institute of Women

  8. Two-step adaptive management for choosing between two management actions.

    Science.gov (United States)

    Moore, Alana L; Walker, Leila; Runge, Michael C; McDonald-Madden, Eve; McCarthy, Michael A

    2017-06-01

    Adaptive management is widely advocated to improve environmental management. Derivations of optimal strategies for adaptive management, however, tend to be case specific and time consuming. In contrast, managers might seek relatively simple guidance, such as insight into when a new potential management action should be considered, and how much effort should be expended on trialing such an action. We constructed a two-time-step scenario where a manager is choosing between two possible management actions. The manager has a total budget that can be split between a learning phase and an implementation phase. We use this scenario to investigate when and how much a manager should invest in learning about the management actions available. The optimal investment in learning can be understood intuitively by accounting for the expected value of sample information, the benefits that accrue during learning, the direct costs of learning, and the opportunity costs of learning. We find that the optimal proportion of the budget to spend on learning is characterized by several critical thresholds that mark a jump from spending a large proportion of the budget on learning to spending nothing. For example, as sampling variance increases, it is optimal to spend a larger proportion of the budget on learning, up to a point: if the sampling variance passes a critical threshold, it is no longer beneficial to invest in learning. Similar thresholds are observed as a function of the total budget and the difference in the expected performance of the two actions. We illustrate how this model can be applied using a case study of choosing between alternative rearing diets for hihi, an endangered New Zealand passerine. Although the model presented is a simplified scenario, we believe it is relevant to many management situations. Managers often have relatively short time horizons for management, and might be reluctant to consider further investment in learning and monitoring beyond collecting data

  9. Two-step adaptive management for choosing between two management actions

    Science.gov (United States)

    Moore, Alana L.; Walker, Leila; Runge, Michael C.; McDonald-Madden, Eve; McCarthy, Michael A

    2017-01-01

    Adaptive management is widely advocated to improve environmental management. Derivations of optimal strategies for adaptive management, however, tend to be case specific and time consuming. In contrast, managers might seek relatively simple guidance, such as insight into when a new potential management action should be considered, and how much effort should be expended on trialing such an action. We constructed a two-time-step scenario where a manager is choosing between two possible management actions. The manager has a total budget that can be split between a learning phase and an implementation phase. We use this scenario to investigate when and how much a manager should invest in learning about the management actions available. The optimal investment in learning can be understood intuitively by accounting for the expected value of sample information, the benefits that accrue during learning, the direct costs of learning, and the opportunity costs of learning. We find that the optimal proportion of the budget to spend on learning is characterized by several critical thresholds that mark a jump from spending a large proportion of the budget on learning to spending nothing. For example, as sampling variance increases, it is optimal to spend a larger proportion of the budget on learning, up to a point: if the sampling variance passes a critical threshold, it is no longer beneficial to invest in learning. Similar thresholds are observed as a function of the total budget and the difference in the expected performance of the two actions. We illustrate how this model can be applied using a case study of choosing between alternative rearing diets for hihi, an endangered New Zealand passerine. Although the model presented is a simplified scenario, we believe it is relevant to many management situations. Managers often have relatively short time horizons for management, and might be reluctant to consider further investment in learning and monitoring beyond collecting data

  10. SPAR-H Step-by-Step Guidance

    Energy Technology Data Exchange (ETDEWEB)

    W. J. Galyean; A. M. Whaley; D. L. Kelly; R. L. Boring

    2011-05-01

    This guide provides step-by-step guidance on the use of the SPAR-H method for quantifying Human Failure Events (HFEs). This guide is intended to be used with the worksheets provided in: 'The SPAR-H Human Reliability Analysis Method,' NUREG/CR-6883, dated August 2005. Each step in the process of producing a Human Error Probability (HEP) is discussed. These steps are: Step-1, Categorizing the HFE as Diagnosis and/or Action; Step-2, Rate the Performance Shaping Factors; Step-3, Calculate PSF-Modified HEP; Step-4, Accounting for Dependence, and; Step-5, Minimum Value Cutoff. The discussions on dependence are extensive and include an appendix that describes insights obtained from the psychology literature.

  11. SPAR-H Step-by-Step Guidance

    International Nuclear Information System (INIS)

    Galyean, W.J.; Whaley, A.M.; Kelly, D.L.; Boring, R.L.

    2011-01-01

    This guide provides step-by-step guidance on the use of the SPAR-H method for quantifying Human Failure Events (HFEs). This guide is intended to be used with the worksheets provided in: 'The SPAR-H Human Reliability Analysis Method,' NUREG/CR-6883, dated August 2005. Each step in the process of producing a Human Error Probability (HEP) is discussed. These steps are: Step-1, Categorizing the HFE as Diagnosis and/or Action; Step-2, Rate the Performance Shaping Factors; Step-3, Calculate PSF-Modified HEP; Step-4, Accounting for Dependence, and; Step-5, Minimum Value Cutoff. The discussions on dependence are extensive and include an appendix that describes insights obtained from the psychology literature.

  12. Kinematic Constraints Associated with the Acquisition of Overarm Throwing Part I: Step and Trunk Actions

    Science.gov (United States)

    Stodden, David F.; Langendorfer, Stephen J.; Fleisig, Glenn S.; Andrews, James R.

    2006-01-01

    The purposes of this study were to: (a) examine differences within specific kinematic variables and ball velocity associated with developmental component levels of step and trunk action (Roberton & Halverson, 1984), and (b) if the differences in kinematic variables were significantly associated with the differences in component levels, determine…

  13. Quantum dynamics via Planck-scale-stepped action-carrying 'Graph Paths'

    CERN Document Server

    Chew, Geoffrey Foucar

    2003-01-01

    A divergence-free, parameter-free, path-based discrete-time quantum dynamics is designed to not only enlarge the achievements of general relativity and the standard particle model, by approximations at spacetime scales far above Planck scale while far below Hubble scale, but to allow tackling of hitherto inaccessible questions. ''Path space'' is larger than and precursor to Hilbert-space basis. The wave-function-propagating paths are action-carrying structured graphs-cubic and quartic structured vertices connected by structured ''fermionic'' or ''bosonic'' ''particle'' and ''nonparticle'' arcs. A Planck-scale path step determines the gravitational constant while controlling all graph structure. The basis of the theory's (zero-rest-mass) elementary-particle Hilbert space (which includes neither gravitons nor scalar bosons) resides in particle arcs. Nonparticle arcs within a path are responsible for energy and rest mass.

  14. SPAR-H Step-by-Step Guidance

    Energy Technology Data Exchange (ETDEWEB)

    April M. Whaley; Dana L. Kelly; Ronald L. Boring; William J. Galyean

    2012-06-01

    Step-by-step guidance was developed recently at Idaho National Laboratory for the US Nuclear Regulatory Commission on the use of the Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) method for quantifying Human Failure Events (HFEs). This work was done to address SPAR-H user needs, specifically requests for additional guidance on the proper application of various aspects of the methodology. This paper overviews the steps of the SPAR-H analysis process and highlights some of the most important insights gained during the development of the step-by-step directions. This supplemental guidance for analysts is applicable when plant-specific information is available, and goes beyond the general guidance provided in existing SPAR-H documentation. The steps highlighted in this paper are: Step-1, Categorizing the HFE as Diagnosis and/or Action; Step-2, Rate the Performance Shaping Factors; Step-3, Calculate PSF-Modified HEP; Step-4, Accounting for Dependence, and; Step-5, Minimum Value Cutoff.

  15. Steps Toward Innovative Childbirth Education: Selected Strategies From the Blueprint for Action

    Science.gov (United States)

    Jolivet, R. Rima; Corry, Maureen P.

    2010-01-01

    To mark the 50th anniversary of Lamaze International, Childbirth Connection celebrates landmark accomplishments in education for childbearing women and families, and takes stock of the changing educational needs and preferences of current childbearing families in looking toward the future. Childbirth Connection's multi-year, multi-stakeholder Transforming Maternity Care initiative resulted in two landmark reports: 2020 Vision for a High-Quality, High-Value Maternity Care System and Blueprint for Action: Steps Toward a High-Quality, High-Value Maternity Care System. Selected recommendations of greatest relevance to the field of childbirth education are discussed, and the new Transforming Maternity Care Partnership is introduced. PMID:21629389

  16. Securing nuclear warheads and materials: seven steps for immediate action

    International Nuclear Information System (INIS)

    Bunn, M.

    2002-01-01

    Full text: In the last decade, substantial progress has been made in improving security and accounting for nuclear weapons and weapons-usable nuclear material worldwide, both by states' own domestic actions and through international cooperation. Thousands of nuclear warheads and hundreds of tons of nuclear material are demonstrably more secure than they were before, and through programs such as the U.S.-Russian Highly Enriched Uranium (He) Purchase Agreement, enough potentially vulnerable bomb material for thousands of nuclear weapons has been verifiably destroyed. Since the attacks of September 11, 2001, the international community has attempted to expand and accelerate these efforts. But much more remains to be done. This paper summarizes a recent report from Harvard University, which recommended seven further steps for immediate action in U.S.-Russian and international cooperation. It covers two recommendations that may be of particular interest to this audience in detail. The first is a proposed program to remove nuclear material entirely from many of the most vulnerable sites around the world (by offering incentives targeted to the needs of each facility to give up the material at that site). The second is a suggestion that participants in the global partnership against the spread of weapons and materials of mass destruction announced at the June 2002 Group of Eight summit make a political commitment to meet stringent security standards for nuclear materials on their territories, and urge (and assist) other states to do likewise. (author)

  17. Science Teachers Taking their First Steps toward Teaching Socioscientific Issues through Collaborative Action Research

    Science.gov (United States)

    Lee, Hyunju; Yang, Jung-eun

    2017-06-01

    This study presents two science teachers, Catherine and Jennifer, who took their first steps toward teaching socioscientific issues through collaborative action research. The teachers participated in the collaborative action research project because they wanted to address socioscientific issues but had limited experience in teaching them. The research questions included what kinds of challenges the teachers encountered when implementing socioscientific issues and to what extent they resolved the challenging issues as participating in collaborative action research. The primary data source consisted of audiotapes of regular group meetings containing information on the process of constructing and implementing lesson plans and reflecting on their teaching of socioscientific issues. We also collected classroom videotapes of the teachers' instruction and audiotapes of students' small group discussions and their worksheets. The findings indicated that when addressing socioscientific issues in the classes, the teachers encountered several challenging issues. We categorized them into four: (1) restructuring classroom dynamics and culture, (2) scaffolding students' engagement in socioscientific issues, (3) dealing with values, and (4) finding their niche in schools. However, this study showed that collaborative action research could be a framework for helping the teachers to overcome such challenges and have successful experiences of teaching socioscientific issues. These experiences became good motivation, to gradually develop their understanding of teaching socioscientific issues and instructional strategies for integrating the knowledge and skills that they had accumulated over the years.

  18. Wrestling with 'doubt-sayers': a first step in leading community-wide climate change action for better health.

    Science.gov (United States)

    Ritchie, Jan

    2011-12-01

    Although the evidence base for climate change is indisputable and the potential human health impact is extremely concerning, to date public health professionals are playing little part in influencing community change to accept and act on the science. In reviewing the techniques used to obstruct action on tobacco control by vested interests through constantly raising doubt about the science in this arena, a similar pattern is seen in obstructing action on climate change. It is clear that the raising of unverified doubt is the primary tool employed by profit-driven corporations to prevent constructive action in both these arenas, with the very high potential for the health of the whole population to suffer as a result. Those promoting the health of Australians have a responsibility to optimise health in this regard and need to think differently through embracing complexity science and then take action, with the first step being to provide constant counter-arguments to the unsubstantiated statements of the 'doubt-sayers'.

  19. Does my step look big in this? A visual illusion leads to safer stepping behaviour.

    Directory of Open Access Journals (Sweden)

    David B Elliott

    Full Text Available BACKGROUND: Tripping is a common factor in falls and a typical safety strategy to avoid tripping on steps or stairs is to increase foot clearance over the step edge. In the present study we asked whether the perceived height of a step could be increased using a visual illusion and whether this would lead to the adoption of a safer stepping strategy, in terms of greater foot clearance over the step edge. The study also addressed the controversial question of whether motor actions are dissociated from visual perception. METHODOLOGY/PRINCIPAL FINDINGS: 21 young, healthy subjects perceived the step to be higher in a configuration of the horizontal-vertical illusion compared to a reverse configuration (p = 0.01. During a simple stepping task, maximum toe elevation changed by an amount corresponding to the size of the visual illusion (p<0.001. Linear regression analyses showed highly significant associations between perceived step height and maximum toe elevation for all conditions. CONCLUSIONS/SIGNIFICANCE: The perceived height of a step can be manipulated using a simple visual illusion, leading to the adoption of a safer stepping strategy in terms of greater foot clearance over a step edge. In addition, the strong link found between perception of a visual illusion and visuomotor action provides additional support to the view that the original, controversial proposal by Goodale and Milner (1992 of two separate and distinct visual streams for perception and visuomotor action should be re-evaluated.

  20. Differential Equations as Actions

    DEFF Research Database (Denmark)

    Ronkko, Mauno; Ravn, Anders P.

    1997-01-01

    We extend a conventional action system with a primitive action consisting of a differential equation and an evolution invariant. The semantics is given by a predicate transformer. The weakest liberal precondition is chosen, because it is not always desirable that steps corresponding to differential...... actions shall terminate. It is shown that the proposed differential action has a semantics which corresponds to a discrete approximation when the discrete step size goes to zero. The extension gives action systems the power to model real-time clocks and continuous evolutions within hybrid systems....

  1. Extraction of Human Stepping Pattern Using Acceleration Sensors

    Directory of Open Access Journals (Sweden)

    Toyohira Takayuki

    2017-01-01

    Full Text Available Gait analysis plays an important role in characterizing individuals and each condition and gait analysis systems have been developed using various devices or instruments. However, most systems do not catch synchronous stepping actions between right foot and left foot. For obtaining a precise gait pattern, a synchronous walking sensing system is developed, in which a pair of acceleration and angular velocity sensors are attached to left and right shoes of a walking person and their data are transmitted to a PC through a wireless channel. Walking data from 19 persons of the age of 14 to 20 are acquired for walking analysis. Stepping time diagrams are extracted from the acquired data of right and left foot actions of stepping-off and-on the ground, and the time diagrams distinguish between an ordinary person and a person injured on left leg, and a stepping recovery process of the injured person is shown. Synchronous sensing of stepping action between right foot and left foot contributes to obtain precise stepping patterns.

  2. Key programmatic steps and activities for implementing the Uranium Mill Tailings Remedial Action Project

    International Nuclear Information System (INIS)

    1985-07-01

    The Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA) was enacted based upon findings by Congress ''that uranium mill tailings located at active and inactive hazard to the public, and that protection of the public health, safety and welfare, and the regulations of interstate commerce, require that every reasonable effort be made to provide for the stabilization, disposal, and control in a safe and environmentally sound manner of such tailings in order to prevent or minimize radon diffusion into the environment and to prevent or minimize other environmental hazards from such tailings.'' A general understanding of the steps leading to elimination of the hazards associated with designated uranium mill tailings sites, and the parties involved in that effort, are presented in this document. A representative schedule is also presented in this document to show both program sequence and activity interdependence. Those activities that have the most potential to influence program duration, because of the significant amount of additional time that may be required, include identification and selection of a suitable site, field data collection delays due to weather, actual acquisition of the designated or alternate disposal site, construction delays due to weather, and site licensing. This document provides an understanding of the steps, the sequence, the parties involved, and a representative duration of activities leading to remedial action and cleanup at the designated inactive uranium mill tailings sites. 10 refs., 5 figs., 1 tab

  3. Stepping out: dare to step forward, step back, or just stand still and breathe.

    Science.gov (United States)

    Waisman, Mary Sue

    2012-01-01

    It is important to step out and make a difference. We have one of the most unique and diverse professions that allows for diversity in thought and practice, permitting each of us to grow in our unique niches and make significant contributions. I was frightened to 'step out' to go to culinary school at the age of 46, but it changed forever the way I look at my profession and I have since experienced the most enjoyable and innovative career. There are also times when it is important to 'step back' to relish the roots of our profession; to help bring food back into nutrition; to translate all of our wonderful science into a language of food that Canadians understand. We all need to take time to 'just stand still and breathe': to celebrate our accomplishments, reflect on our actions, ensure we are heading toward our vision, keep the profession vibrant and relevant, and cherish one another.

  4. Habits as action sequences: hierarchical action control and changes in outcome value.

    Science.gov (United States)

    Dezfouli, Amir; Lingawi, Nura W; Balleine, Bernard W

    2014-11-05

    Goal-directed action involves making high-level choices that are implemented using previously acquired action sequences to attain desired goals. Such a hierarchical schema is necessary for goal-directed actions to be scalable to real-life situations, but results in decision-making that is less flexible than when action sequences are unfolded and the decision-maker deliberates step-by-step over the outcome of each individual action. In particular, from this perspective, the offline revaluation of any outcomes that fall within action sequence boundaries will be invisible to the high-level planner resulting in decisions that are insensitive to such changes. Here, within the context of a two-stage decision-making task, we demonstrate that this property can explain the emergence of habits. Next, we show how this hierarchical account explains the insensitivity of over-trained actions to changes in outcome value. Finally, we provide new data that show that, under extended extinction conditions, habitual behaviour can revert to goal-directed control, presumably as a consequence of decomposing action sequences into single actions. This hierarchical view suggests that the development of action sequences and the insensitivity of actions to changes in outcome value are essentially two sides of the same coin, explaining why these two aspects of automatic behaviour involve a shared neural structure. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  5. Validity of the Stages of Change in Steps instrument (SoC-Step) for achieving the physical activity goal of 10,000 steps per day.

    Science.gov (United States)

    Rosenkranz, Richard R; Duncan, Mitch J; Caperchione, Cristina M; Kolt, Gregory S; Vandelanotte, Corneel; Maeder, Anthony J; Savage, Trevor N; Mummery, W Kerry

    2015-11-30

    Physical activity (PA) offers numerous benefits to health and well-being, but most adults are not sufficiently physically active to afford such benefits. The 10,000 steps campaign has been a popular and effective approach to promote PA. The Transtheoretical Model posits that individuals have varying levels of readiness for health behavior change, known as Stages of Change (Precontemplation, Contemplation, Preparation, Action, and Maintenance). Few validated assessment instruments are available for determining Stages of Change in relation to the PA goal of 10,000 steps per day. The purpose of this study was to assess the criterion-related validity of the SoC-Step, a brief 10,000 steps per day Stages of Change instrument. Participants were 504 Australian adults (176 males, 328 females, mean age = 50.8 ± 13.0 years) from the baseline sample of the Walk 2.0 randomized controlled trial. Measures included 7-day accelerometry (Actigraph GT3X), height, weight, and self-reported intention, self-efficacy, and SoC-Step: Stages of Change relative to achieving 10,000 steps per day. Kruskal-Wallis H tests with pairwise comparisons were used to determine whether participants differed by stage, according to steps per day, general health, body mass index, intention, and self-efficacy to achieve 10,000 steps per day. Binary logistic regression was used to test the hypothesis that participants in Maintenance or Action stages would have greater likelihood of meeting the 10,000 steps goal, in comparison to participants in the other three stages. Consistent with study hypotheses, participants in Precontemplation had significantly lower intention scores than those in Contemplation (p = 0.003) or Preparation (p per day (OR = 3.11; 95 % CI = 1.66,5.83) compared to those in Precontemplation, Contemplation, or Preparation. Intention (p per day. Australian New Zealand Clinical Trials Registry reference: ACTRN12611000157976 World Health Organization Universal Trial

  6. Quadratic adaptive algorithm for solving cardiac action potential models.

    Science.gov (United States)

    Chen, Min-Hung; Chen, Po-Yuan; Luo, Ching-Hsing

    2016-10-01

    An adaptive integration method is proposed for computing cardiac action potential models accurately and efficiently. Time steps are adaptively chosen by solving a quadratic formula involving the first and second derivatives of the membrane action potential. To improve the numerical accuracy, we devise an extremum-locator (el) function to predict the local extremum when approaching the peak amplitude of the action potential. In addition, the time step restriction (tsr) technique is designed to limit the increase in time steps, and thus prevent the membrane potential from changing abruptly. The performance of the proposed method is tested using the Luo-Rudy phase 1 (LR1), dynamic (LR2), and human O'Hara-Rudy dynamic (ORd) ventricular action potential models, and the Courtemanche atrial model incorporating a Markov sodium channel model. Numerical experiments demonstrate that the action potential generated using the proposed method is more accurate than that using the traditional Hybrid method, especially near the peak region. The traditional Hybrid method may choose large time steps near to the peak region, and sometimes causes the action potential to become distorted. In contrast, the proposed new method chooses very fine time steps in the peak region, but large time steps in the smooth region, and the profiles are smoother and closer to the reference solution. In the test on the stiff Markov ionic channel model, the Hybrid blows up if the allowable time step is set to be greater than 0.1ms. In contrast, our method can adjust the time step size automatically, and is stable. Overall, the proposed method is more accurate than and as efficient as the traditional Hybrid method, especially for the human ORd model. The proposed method shows improvement for action potentials with a non-smooth morphology, and it needs further investigation to determine whether the method is helpful during propagation of the action potential. Copyright © 2016 Elsevier Ltd. All rights

  7. Computational Abstraction Steps

    DEFF Research Database (Denmark)

    Thomsen, Lone Leth; Thomsen, Bent; Nørmark, Kurt

    2010-01-01

    and class instantiations. Our teaching experience shows that many novice programmers find it difficult to write programs with abstractions that materialise to concrete objects later in the development process. The contribution of this paper is the idea of initiating a programming process by creating...... or capturing concrete values, objects, or actions. As the next step, some of these are lifted to a higher level by computational means. In the object-oriented paradigm the target of such steps is classes. We hypothesise that the proposed approach primarily will be beneficial to novice programmers or during...... the exploratory phase of a program development process. In some specific niches it is also expected that our approach will benefit professional programmers....

  8. 77 FR 38709 - Surface Transportation Environment and Planning Cooperative Research Program (STEP)

    Science.gov (United States)

    2012-06-28

    ... Planning Cooperative Research Program (STEP) AGENCY: Federal Highway Administration (FHWA), DOT. ACTION... Research Program (STEP). The FHWA anticipates that the STEP or a similar program to provide resources for... stakeholders that can leverage limited research funding in the STEP with other stakeholders and partners in...

  9. 75 FR 38605 - Surface Transportation Environment and Planning Cooperative Research Program (STEP)

    Science.gov (United States)

    2010-07-02

    ... Planning Cooperative Research Program (STEP) AGENCY: Federal Highway Administration (FHWA), DOT. ACTION... Research Program (STEP). The FHWA anticipates that the STEP or a similar program to provide resources for... limited research funding in the STEP with other stakeholders and partners in order to increase the total...

  10. 76 FR 50312 - Surface Transportation Environment and Planning Cooperative Research Program (STEP)

    Science.gov (United States)

    2011-08-12

    ... Planning Cooperative Research Program (STEP) AGENCY: Federal Highway Administration (FHWA), DOT. ACTION... Research Program (STEP). The FHWA anticipates that the STEP or a similar program to provide resources for... limited research funding in the STEP with other stakeholders and partners in order to increase the total...

  11. Aquation Is a Crucial Activation Step for Anticancer Action of Ruthenium(II) Polypyridyl Complexes to Trigger Cancer Cell Apoptosis.

    Science.gov (United States)

    Li, Meng; Lai, Lanhai; Zhao, Zhennan; Chen, Tianfeng

    2016-01-01

    Aquation has been proposed as crucial chemical action step for ruthenium (Ru) complexes, but its effects on the action mechanisms remain elusive. Herein, we have demonstrated the aquation process of a potent Ru polypyridyl complex (RuBmp=[Ru(II) (bmbp)(phen)Cl]ClO4 , bmbp=2,6-bis(6-methylbenzimidazol-2-yl) pyridine, phen=phenanthroline) with a chloride ligand, and revealed that aquation of RuBmp effectively enhanced its hydrophilicity and cellular uptake, thus significantly increasing its anticancer efficacy. The aquation products (H-RuBmp=[Ru(II) (bmbp)(phen)Cl]ClO4 , [Ru(II) (bmbp)(phen)(H2 O)]ClO4 , bmbp) exhibited a much higher apoptosis-inducing ability than the intact complex, with involvement of caspase activation, mitochondria dysfunction, and interaction with cell membrane death receptors. H-RuBmp demonstrated a higher interaction potency with the cell membrane and induced higher levels of ROS overproduction in cancer cells to regulate the AKT, MAPK, and p53 signaling pathways. Taken together, this study could provide useful information for fine-tuning the rational design of next-generation metal medicines. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. American Samoa: Energy Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    Ness, J. Erik [National Renewable Energy Lab. (NREL), Golden, CO (United States); Haase, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Conrad, Misty [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-09-01

    This document outlines actions being taken to reduce American Samoa's petroleum consumption. It describes the four near-term strategies selected by the American Samoa Renewable Energy Committee during action-planning workshops conducted in May 2016, and describes the steps that will need to be taken to implement those strategies.

  13. Climate Action Planning Process | Climate Neutral Research Campuses | NREL

    Science.gov (United States)

    Action Planning Process Climate Action Planning Process For research campuses, NREL has developed a five-step process to develop and implement climate action plans: Determine baseline energy consumption Analyze technology options Prepare a plan and set priorities Implement the climate action plan Measure and

  14. Noise Enhances Action Potential Generation in Mouse Sensory Neurons via Stochastic Resonance.

    Science.gov (United States)

    Onorato, Irene; D'Alessandro, Giuseppina; Di Castro, Maria Amalia; Renzi, Massimiliano; Dobrowolny, Gabriella; Musarò, Antonio; Salvetti, Marco; Limatola, Cristina; Crisanti, Andrea; Grassi, Francesca

    2016-01-01

    Noise can enhance perception of tactile and proprioceptive stimuli by stochastic resonance processes. However, the mechanisms underlying this general phenomenon remain to be characterized. Here we studied how externally applied noise influences action potential firing in mouse primary sensory neurons of dorsal root ganglia, modelling a basic process in sensory perception. Since noisy mechanical stimuli may cause stochastic fluctuations in receptor potential, we examined the effects of sub-threshold depolarizing current steps with superimposed random fluctuations. We performed whole cell patch clamp recordings in cultured neurons of mouse dorsal root ganglia. Noise was added either before and during the step, or during the depolarizing step only, to focus onto the specific effects of external noise on action potential generation. In both cases, step + noise stimuli triggered significantly more action potentials than steps alone. The normalized power norm had a clear peak at intermediate noise levels, demonstrating that the phenomenon is driven by stochastic resonance. Spikes evoked in step + noise trials occur earlier and show faster rise time as compared to the occasional ones elicited by steps alone. These data suggest that external noise enhances, via stochastic resonance, the recruitment of transient voltage-gated Na channels, responsible for action potential firing in response to rapid step-wise depolarizing currents.

  15. Egocentric Temporal Action Proposals.

    Science.gov (United States)

    Shao Huang; Weiqiang Wang; Shengfeng He; Lau, Rynson W H

    2018-02-01

    We present an approach to localize generic actions in egocentric videos, called temporal action proposals (TAPs), for accelerating the action recognition step. An egocentric TAP refers to a sequence of frames that may contain a generic action performed by the wearer of a head-mounted camera, e.g., taking a knife, spreading jam, pouring milk, or cutting carrots. Inspired by object proposals, this paper aims at generating a small number of TAPs, thereby replacing the popular sliding window strategy, for localizing all action events in the input video. To this end, we first propose to temporally segment the input video into action atoms, which are the smallest units that may contain an action. We then apply a hierarchical clustering algorithm with several egocentric cues to generate TAPs. Finally, we propose two actionness networks to score the likelihood of each TAP containing an action. The top ranked candidates are returned as output TAPs. Experimental results show that the proposed TAP detection framework performs significantly better than relevant approaches for egocentric action detection.

  16. Insulin action in human thighs after one-legged immobilization

    DEFF Research Database (Denmark)

    Richter, Erik; Kiens, Bente; Mizuno, M.

    1989-01-01

    Insulin action was assessed in thighs of five healthy young males who had one knee immobilized for 7 days by a splint. The splint was not worn in bed. Subjects also used crutches to prevent weight bearing of the immobilized leg. Immobilization decreased the activity of citrate synthase and 3-OH......-acyl-CoA-dehydrogenase in the vastus lateralis muscle by 9 and 14%, respectively, and thigh volume by 5%. After 7 days of immobilization, a two-step euglycemic hyperinsulinemic clamp procedure combined with arterial and bilateral femoral venous catheterization was performed. Insulin action on glucose uptake and tyrosine release...... of the thighs at mean plasma insulin concentrations of 67 (clamp step I) and 447 microU/ml (clamp step II) was decreased by immobilization, whereas immobilization did not affect insulin action on thigh exchange of free fatty acids, glycerol, O2, or potassium. Before and during the clamp step I, lactate release...

  17. Texas strategic action plan for motorcycles : 2013-2018.

    Science.gov (United States)

    2013-06-01

    The Texas Strategic Action Plan for Motorcycles: 2013-2018 provides an integrated : approach to identify implementable strategies and action steps to make the : road environment and infrastructure safer for motorcyclists and other powered : two- and ...

  18. Infants Prospectively Control Reaching Based on the Difficulty of Future Actions: To What Extent Can Infants' Multiple-Step Actions Be Explained by Fitts' Law?

    Science.gov (United States)

    Gottwald, Janna M.; De Bortoli Vizioli, Aurora; Lindskog, Marcus; Nyström, Pär; L. Ekberg, Therese; von Hofsten, Claes; Gredebäck, Gustaf

    2017-01-01

    Prospective motor control, a key element of action planning, is the ability to adjust one's actions with respect to task demands and action goals in an anticipatory manner. The current study investigates whether 14-month-olds can prospectively control their reaching actions based on the difficulty of the subsequent action. We used a reach-to-place…

  19. Aspects you should consider in your action plan when implementing an improvement strategy

    DEFF Research Database (Denmark)

    Carstensen, Peter; Vinter, Otto

    2017-01-01

    Both ISO/IEC 15504 (SPICE) and ISO/IEC 33014 include a step in their improvement process called: Develop action plan. But which actions should you include, and are you sure that these actions cover all aspects? We have performed a thorough study of the change strategy literature that is the found......Both ISO/IEC 15504 (SPICE) and ISO/IEC 33014 include a step in their improvement process called: Develop action plan. But which actions should you include, and are you sure that these actions cover all aspects? We have performed a thorough study of the change strategy literature...

  20. Corrective Action Decision Document/Corrective Action Plan for Corrective Action Unit 98: Frenchman Flat, Nevada National Security Site, Nevada, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Irene Farnham and Sam Marutzky

    2011-07-01

    This CADD/CAP follows the Corrective Action Investigation (CAI) stage, which results in development of a set of contaminant boundary forecasts produced from groundwater flow and contaminant transport modeling of the Frenchman Flat CAU. The Frenchman Flat CAU is located in the southeastern portion of the NNSS and comprises 10 underground nuclear tests. The tests were conducted between 1965 and 1971 and resulted in the release of radionuclides in the subsurface in the vicinity of the test cavities. Two important aspects of the corrective action process are presented within this CADD/CAP. The CADD portion describes the results of the Frenchman Flat CAU data-collection and modeling activities completed during the CAI stage. The corrective action objectives and the actions recommended to meet the objectives are also described. The CAP portion describes the corrective action implementation plan. The CAP begins with the presentation of CAU regulatory boundary objectives and initial use restriction boundaries that are identified and negotiated by NNSA/NSO and the Nevada Division of Environmental Protection (NDEP). The CAP also presents the model evaluation process designed to build confidence that the flow and contaminant transport modeling results can be used for the regulatory decisions required for CAU closure. The first two stages of the strategy have been completed for the Frenchman Flat CAU. A value of information analysis and a CAIP were developed during the CAIP stage. During the CAI stage, a CAIP addendum was developed, and the activities proposed in the CAIP and addendum were completed. These activities included hydrogeologic investigation of the underground testing areas, aquifer testing, isotopic and geochemistry-based investigations, and integrated geophysical investigations. After these investigations, a groundwater flow and contaminant transport model was developed to forecast contaminant boundaries that enclose areas potentially exceeding the Safe Drinking

  1. Five Steps for Structuring Data-Informed Conversations and Action in Education. REL 2013-001

    Science.gov (United States)

    Kekahio, Wendy; Baker, Myriam

    2013-01-01

    Using data strategically to guide decisions and actions can have a positive effect on education practices and processes. This facilitation guide shows education data teams how to move beyond simply reporting data to applying data to direct strategic action. Using guiding questions, suggested activities, and activity forms, this guide provides…

  2. The Bali action plan: a first step towards a global agreement on climate?

    International Nuclear Information System (INIS)

    Wemaere, M.; Tubiana, L.

    2007-01-01

    The authors present and discuss the main conclusions and advances of the Bali Conference on climate change (1-15 December 2007). This conference adopted a text, an action plan, which does not mention any precise objective in terms of emission reductions, but organizes the negotiation around four 'building blocks'. The authors present and comment these four blocks: the climate change mitigation, the adaptation, the technological cooperation for the mitigation of climate change and for the adaptation to this change, and the financing of adaptation and mitigation actions

  3. School Climate Improvement Action Guide for Instructional Staff. School Climate Improvement Resource Package

    Science.gov (United States)

    National Center on Safe Supportive Learning Environments, 2017

    2017-01-01

    Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines key action steps that instructional staff--including teachers, paraprofessionals, and others in the classroom who provide instruction or assistance--can take to support school climate improvements. Key action steps are provided…

  4. School Climate Improvement Action Guide for District Leaders. School Climate Improvement Resource Package

    Science.gov (United States)

    National Center on Safe Supportive Learning Environments, 2017

    2017-01-01

    Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines key action steps that district leaders--including superintendents, assistant superintendents, directors of student support services, or others--can take to support school climate improvements. Key action steps are provided for…

  5. Recognition of Action as a Bayesian Parameter Estimation Problem over Time

    DEFF Research Database (Denmark)

    Krüger, Volker

    2007-01-01

    In this paper we will discuss two problems related to action recognition: The first problem is the one of identifying in a surveillance scenario whether a person is walking or running and in what rough direction. The second problem is concerned with the recovery of action primitives from observed...... complex actions. Both problems will be discussed within a statistical framework. Bayesian propagation over time offers a framework to treat likelihood observations at each time step and the dynamics between the time steps in a unified manner. The first problem will be approached as a patter recognition...... of the Bayesian framework for action recognition and round up our discussion....

  6. School Climate Improvement Action Guide for School Leaders. School Climate Improvement Resource Package

    Science.gov (United States)

    National Center on Safe Supportive Learning Environments, 2017

    2017-01-01

    Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines key action steps that school leaders--including principals, assistant/vice principals, and building leaders--can take to support school climate improvements. Key action steps are provided for the following strategies: (1)…

  7. Learning a Mid-Level Representation for Multiview Action Recognition

    Directory of Open Access Journals (Sweden)

    Cuiwei Liu

    2018-01-01

    Full Text Available Recognizing human actions in videos is an active topic with broad commercial potentials. Most of the existing action recognition methods are supposed to have the same camera view during both training and testing. And thus performances of these single-view approaches may be severely influenced by the camera movement and variation of viewpoints. In this paper, we address the above problem by utilizing videos simultaneously recorded from multiple views. To this end, we propose a learning framework based on multitask random forest to exploit a discriminative mid-level representation for videos from multiple cameras. In the first step, subvolumes of continuous human-centered figures are extracted from original videos. In the next step, spatiotemporal cuboids sampled from these subvolumes are characterized by multiple low-level descriptors. Then a set of multitask random forests are built upon multiview cuboids sampled at adjacent positions and construct an integrated mid-level representation for multiview subvolumes of one action. Finally, a random forest classifier is employed to predict the action category in terms of the learned representation. Experiments conducted on the multiview IXMAS action dataset illustrate that the proposed method can effectively recognize human actions depicted in multiview videos.

  8. Evaluation of accuracy in implant site preparation performed in single- or multi-step drilling procedures.

    Science.gov (United States)

    Marheineke, Nadine; Scherer, Uta; Rücker, Martin; von See, Constantin; Rahlf, Björn; Gellrich, Nils-Claudius; Stoetzer, Marcus

    2018-06-01

    Dental implant failure and insufficient osseointegration are proven results of mechanical and thermal damage during the surgery process. We herein performed a comparative study of a less invasive single-step drilling preparation protocol and a conventional multiple drilling sequence. Accuracy of drilling holes was precisely analyzed and the influence of different levels of expertise of the handlers and additional use of drill template guidance was evaluated. Six experimental groups, deployed in an osseous study model, were representing template-guided and freehanded drilling actions in a stepwise drilling procedure in comparison to a single-drill protocol. Each experimental condition was studied by the drilling actions of respectively three persons without surgical knowledge as well as three highly experienced oral surgeons. Drilling actions were performed and diameters were recorded with a precision measuring instrument. Less experienced operators were able to significantly increase the drilling accuracy using a guiding template, especially when multi-step preparations are performed. Improved accuracy without template guidance was observed when experienced operators were executing single-step versus multi-step technique. Single-step drilling protocols have shown to produce more accurate results than multi-step procedures. The outcome of any protocol can be further improved by use of guiding templates. Operator experience can be a contributing factor. Single-step preparations are less invasive and are promoting osseointegration. Even highly experienced surgeons are achieving higher levels of accuracy by combining this technique with template guidance. Hereby template guidance enables a reduction of hands-on time and side effects during surgery and lead to a more predictable clinical diameter.

  9. PTTSA Action Plan Report

    International Nuclear Information System (INIS)

    1991-02-01

    The Pre-Tiger Team Self-Assessment (PTTSA) Report identified findings with respect to the way Sandia National Laboratories (SNL), Albuquerque, (including Tonopah Test Range (TTR) and Kauai Test Facility (KTF)) conducts its environment, safety, and health (ES ampersand H) activities. It presented Action Plan Requirements (APR) addressing these findings. The purpose of this PTTSA Action Plan Report is to assist in managing these action plan requirements by collecting, prioritizing, and estimating required resources. The specific objectives addressed by this report include: collection of requirements for the resolution of the findings presented in the PTTSA Report; consolidation of proposed Action Plan Requirements into logical Action Plan groupings for efficiency of resolution; categorization of Action Plans according to severity of the hazards represented by the findings; provision of a basis for long-range planning and issues management; documentation of the status of the proposed corrective actions; establishment of traceability of the corrective action to the original problem or issue; and integration of these plans into the existing ES ampersand H structure. The Action Plans in this report are an intermediate step between the identification of a problem or a finding in the PTTSA Report and the execution of the solution. They consist of requirements for solution, proposed actions, and an estimate of the time and (where applicable) resources required to develop the solution. This report is an input to the process of planning, resource commitment, development, testing, implementation, and maintenance of problem resolution. 2 figs

  10. School Climate Improvement Action Guide for Working with Students. School Climate Improvement Resource Package

    Science.gov (United States)

    National Center on Safe Supportive Learning Environments, 2017

    2017-01-01

    Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines key action steps to engage students in the school climate improvement process. Key action steps are provided for the following strategies: (1) Participate in planning for school climate improvements; (2) Engage stakeholders in…

  11. One Step In and One Step Out : The Lived Experience of the Deferred Action for Childhood Arrivals Program

    OpenAIRE

    Kosnac, Hillary Sue

    2014-01-01

    After over a decade of congressional stalemate on the Development, Relief and Education for Alien Minors (DREAM) Act, the Obama administration announced the Deferred Action for Childhood Arrivals (DACA) program in the summer of 2012. A form of prosecutorial discretion, DACA offers certain undocumented youth a two-year reprieve from deportation, employment authorization and, in some states like California, a driver's license. Nevertheless, because DACA does not provide a pathway to citizenship...

  12. Description of the effort sharing approaches as presented in the Ecofys' policy brief The next step in Europe's climate action. Setting targets for 2030

    Energy Technology Data Exchange (ETDEWEB)

    Hoehne, N.; Hagemann, M.; Fekete, H. [Ecofys, Utrecht (Netherlands)

    2013-06-15

    The paper 'The next step in Europe's climate action. Setting targets for 2030' explains how setting 2030 targets will reinvigorate the ETS and will put EU emissions on track to limit global temperature increase below two degrees Celsius (2C). The paper describes four key findings for EU policymakers engaged in preparing EU energy and climate measures for 2030 and for the longer term. This document aims to provide background information on the effort sharing approaches, as presented in fore-mentioned paper.

  13. Global Monitoring Of Uranium Hexifloride Cylinders Next Steps In Development Of An Action Plan

    International Nuclear Information System (INIS)

    Hanks, D.

    2010-01-01

    Over 40 industrial facilities world-wide use standardized uranium hexafluoride (UF 6 ) cylinders for transport, storage and in-process receiving in support of uranium conversion, enrichment and fuel fabrication processes. UF 6 is processed and stored in the cylinders, with over 50,000 tU of UF 6 transported each year in these International Organization for Standardization (ISO) qualified containers. Although each cylinder is manufactured to an ISO standard that calls for a nameplate with the manufacturer's identification number (ID) and the owner's serial number engraved on it, these can be quite small and difficult to read. Recognizing that each facility seems to use a different ID, a cylinder can have several different numbers recorded on it by means of metal plates, sticky labels, paint or even marker pen as it travels among facilities around the world. The idea of monitoring movements of UF 6 cylinders throughout the global uranium fuel cycle has become a significant issue among industrial and safeguarding stakeholders. Global monitoring would provide the locations, movements, and uses of cylinders in commercial nuclear transport around the world, improving the efficiency of industrial operations while increasing the assurance that growing nuclear commerce does not result in the loss or misuse of cylinders. It should be noted that a unique ID (UID) attached to a cylinder in a verifiable manner is necessary for safeguarding needs and ensuring positive ID, but not sufficient for an effective global monitoring system. Modern technologies for tracking and inventory control can pair the UID with sensors and secure data storage for content information and complete continuity of knowledge over the cylinder. This paper will describe how the next steps in development of an action plan for employing a global UF 6 cylinder monitoring network could be cultivated using four primary UID functions - identification, tracking, controlling, and accounting.

  14. Planning-in-Action: An Innovative Approach to Human Development. The Hunger Project.

    Science.gov (United States)

    Community Development Journal, 1991

    1991-01-01

    The Hunger Project in India used a strategic planning-in-action approach that involved (1) reaching a common understanding; (2) creating a strategic intent; (3) choosing social indicators; (4) identifying strategic objectives; (5) empowering leadership; (6) identifying immediate action steps; and (7) sustaining the action. (SK)

  15. A physical action potential generator: design, implementation and evaluation.

    Science.gov (United States)

    Latorre, Malcolm A; Chan, Adrian D C; Wårdell, Karin

    2015-01-01

    The objective was to develop a physical action potential generator (Paxon) with the ability to generate a stable, repeatable, programmable, and physiological-like action potential. The Paxon has an equivalent of 40 nodes of Ranvier that were mimicked using resin embedded gold wires (Ø = 20 μm). These nodes were software controlled and the action potentials were initiated by a start trigger. Clinically used Ag-AgCl electrodes were coupled to the Paxon for functional testing. The Paxon's action potential parameters were tunable using a second order mathematical equation to generate physiologically relevant output, which was accomplished by varying the number of nodes involved (1-40 in incremental steps of 1) and the node drive potential (0-2.8 V in 0.7 mV steps), while keeping a fixed inter-nodal timing and test electrode configuration. A system noise floor of 0.07 ± 0.01 μV was calculated over 50 runs. A differential test electrode recorded a peak positive amplitude of 1.5 ± 0.05 mV (gain of 40x) at time 196.4 ± 0.06 ms, including a post trigger delay. The Paxon's programmable action potential like signal has the possibility to be used as a validation test platform for medical surface electrodes and their attached systems.

  16. ActionScript 30 Design Patterns Object Oriented Programming Techniques

    CERN Document Server

    Sanders, William

    2008-01-01

    If you're an experienced Flash or Flex developer ready to tackle sophisticated programming techniques with ActionScript 3.0, this hands-on introduction to design patterns takes you step by step through the process. You learn about various types of design patterns and construct small abstract examples before trying your hand at building full-fledged working applications outlined in the book.

  17. Exploring the Relationships Between USMLE Performance and Disciplinary Action in Practice: A Validity Study of Score Inferences From a Licensure Examination.

    Science.gov (United States)

    Cuddy, Monica M; Young, Aaron; Gelman, Andrew; Swanson, David B; Johnson, David A; Dillon, Gerard F; Clauser, Brian E

    2017-12-01

    Physicians must pass the United States Medical Licensing Examination (USMLE) to obtain an unrestricted license to practice allopathic medicine in the United States. Little is known, however, about how well USMLE performance relates to physician behavior in practice, particularly conduct inconsistent with safe, effective patient care. The authors examined the extent to which USMLE scores relate to the odds of receiving a disciplinary action from a U.S. state medical board. Controlling for multiple factors, the authors used non-nested multilevel logistic regression analyses to estimate the relationships between scores and receiving an action. The sample included 164,725 physicians who graduated from U.S. MD-granting medical schools between 1994 and 2006. Physicians had a mean Step 1 score of 214 (standard deviation [SD] = 21) and a mean Step 2 Clinical Knowledge (CK) score of 213 (SD = 23). Of the physicians, 2,205 (1.3%) received at least one action. Physicians with higher Step 2 CK scores had lower odds of receiving an action. A 1-SD increase in Step 2 CK scores corresponded to a decrease in the chance of disciplinary action by roughly 25% (odds ratio = 0.75; 95% CI = 0.70-0.80). After accounting for Step 2 CK scores, Step 1 scores were unrelated to the odds of receiving an action. USMLE Step 2 CK scores provide useful information about the odds a physician will receive an official sanction for problematic practice behavior. These results provide validity evidence supporting current interpretation and use of Step 2 CK scores.

  18. GLOBAL MONITORING OF URANIUM HEXIFLORIDE CYLINDERS NEXT STEPS IN DEVELOPMENT OF AN ACTION PLAN

    Energy Technology Data Exchange (ETDEWEB)

    Hanks, D.

    2010-06-09

    Over 40 industrial facilities world-wide use standardized uranium hexafluoride (UF{sub 6}) cylinders for transport, storage and in-process receiving in support of uranium conversion, enrichment and fuel fabrication processes. UF{sub 6} is processed and stored in the cylinders, with over 50,000 tU of UF{sub 6} transported each year in these International Organization for Standardization (ISO) qualified containers. Although each cylinder is manufactured to an ISO standard that calls for a nameplate with the manufacturer's identification number (ID) and the owner's serial number engraved on it, these can be quite small and difficult to read. Recognizing that each facility seems to use a different ID, a cylinder can have several different numbers recorded on it by means of metal plates, sticky labels, paint or even marker pen as it travels among facilities around the world. The idea of monitoring movements of UF{sub 6} cylinders throughout the global uranium fuel cycle has become a significant issue among industrial and safeguarding stakeholders. Global monitoring would provide the locations, movements, and uses of cylinders in commercial nuclear transport around the world, improving the efficiency of industrial operations while increasing the assurance that growing nuclear commerce does not result in the loss or misuse of cylinders. It should be noted that a unique ID (UID) attached to a cylinder in a verifiable manner is necessary for safeguarding needs and ensuring positive ID, but not sufficient for an effective global monitoring system. Modern technologies for tracking and inventory control can pair the UID with sensors and secure data storage for content information and complete continuity of knowledge over the cylinder. This paper will describe how the next steps in development of an action plan for employing a global UF{sub 6} cylinder monitoring network could be cultivated using four primary UID functions - identification, tracking, controlling, and

  19. Emotions in action through the looking glass.

    Science.gov (United States)

    Sinigaglia, Corrado; Sparaci, Laura

    2010-02-01

    The paper aims at highlighting how our primary understanding of others' actions is rooted in the mirror mechanism. To this end, the anatomical architecture of the mirror neuron system for action will be outlined as well as its role in grasping goals and intentions in others' motor behaviour. One further step through the looking glass of social cognition will be referring to the ubiquitous emotional colouring of actions and considering its links with the motor domain. This will allow a clearer perspective on the mechanism underlying our abilities for emotional understanding and on cases in which these abilities are amiss, as in autistic spectrum disorders.

  20. 29 CFR 1608.4 - Establishing affirmative action plans.

    Science.gov (United States)

    2010-07-01

    ... taken pursuant to an affirmative action plan or program must be reasonable in relation to the problems... remedy the situation. Such steps, which in design and execution may be race, color, sex or ethnic...

  1. Aspects you should consider in your action plan when implementing an improvement strategy

    DEFF Research Database (Denmark)

    Carstensen, Peter; Vinter, Otto

    2017-01-01

    Both ISO/IEC 15504 (SPICE) and ISO/IEC 33014 include a step in their improvement process called: Develop action plan. But which actions should you include, and are you sure that these actions cover all aspects? We have performed a thorough study of the change strategy literature that is the found...

  2. Step out - Step in Sequencing Games

    NARCIS (Netherlands)

    Musegaas, M.; Borm, P.E.M.; Quant, M.

    2014-01-01

    In this paper a new class of relaxed sequencing games is introduced: the class of Step out - Step in sequencing games. In this relaxation any player within a coalition is allowed to step out from his position in the processing order and to step in at any position later in the processing order.

  3. A step-by-step guide for countries conducting a Technology Needs Assessment

    DEFF Research Database (Denmark)

    Haselip, James Arthur; Narkeviciute, Rasa; Rogat Castillo, Jorge Enrique

    . For this new TNA Phase II (2015-2017), we reflect upon experience from the 36 countries in the TNA Phase I (2010-2013) and offer country case-study examples to help illustrate how the project can be organised and implemented. Links to the full electronic (.pdf) versions of the guidance documents are provided......The purpose of this document is to summarise the various steps in the implementation of a TNA, serving as the ‘go-to’ document for national coordinators and consultants. It also points to the various materials that are available to further guide and support project management and methodology...... in this guidance note and can be downloaded from the TNA project website www.tech-action.org under ‘Publications’....

  4. Step out-step in sequencing games

    NARCIS (Netherlands)

    Musegaas, Marieke; Borm, Peter; Quant, Marieke

    2015-01-01

    In this paper a new class of relaxed sequencing games is introduced: the class of Step out–Step in sequencing games. In this relaxation any player within a coalition is allowed to step out from his position in the processing order and to step in at any position later in the processing order. First,

  5. APT: Action localization Proposals from dense Trajectories

    NARCIS (Netherlands)

    van Gemert, J.C.; Jain, M.; Gati, E.; Snoek, C.G.M.; Xie, X.; Jones, M.W.; Tam, G.K.L.

    2015-01-01

    This paper is on action localization in video with the aid of spatio-temporal proposals. To alleviate the computational expensive video segmentation step of existing proposals, we propose bypassing the segmentations completely by generating proposals directly from the dense trajectories used to

  6. Nationally Appropriate Mitigation Action: Understanding NAMA Cycle

    DEFF Research Database (Denmark)

    Sharma, Sudhir; Desgain, Denis DR

    There is no internationally defined or agreed Nationally Appropriate Mitigation Action(NAMA) cycle, as was the case, for example, with the Clean Development Mechanisms (CDM) project cycle. However, there are some common steps that NAMA identification, formulation, and implementation will all go...

  7. Working together in future: next steps

    International Nuclear Information System (INIS)

    Copeland, S.

    2001-01-01

    Some questions about public trust have to find answers: the language of safety, how much is enough, how much is too much for stake holder interaction, how do you deal with the issue of responding, i.e. demonstrating action on issues when the licensing decision is not what public groups want, how do you measure the success of consultations, what are the indicators for trust, benchmarking and measuring public perceptions, need for consistency of approach (can determine public confidence by differences between countries) are so many questions that could help for next steps. (N.C.)

  8. 24 CFR 55.12 - Inapplicability of 24 CFR part 55 to certain categories of proposed actions.

    Science.gov (United States)

    2010-04-01

    ... proposed actions. (a) The decision making steps in § 55.20 (b), (c) and (g) (steps 2, 3 and 7) shall not... the footprint of the structure and paved areas is not significantly increased. (b) The decision making...'s actions under section 223(f) of the National Housing Act (12 U.S.C. 1715n(f)) for the purchase or...

  9. Banning Corporal Punishment: A Crucial Step toward Preventing Child Abuse.

    Science.gov (United States)

    Moelis, Cindy S.

    1988-01-01

    Banning school corporal punishment is supported as a step towards gradually eliminating all violent actions toward children. The 39 states that allow corporal punishment are encouraged to outlaw it, to teach children that it is not socially acceptable behavior and to set an example for families' child-rearing attitudes and practices. (JDD)

  10. Institutional capacity and climate actions. Summary paper

    International Nuclear Information System (INIS)

    Willems, S.

    2004-01-01

    The aim of this paper is to explore the role of institutional capacity in selecting the most appropriate climate actions. More specifically, it investigates why, for some countries, institutional capacity may need to be considered as an important criterion for selecting future climate actions, alongside environmental, economic and/or political considerations. This paper is a synthesis of results of an OECD/IEA project undertaken in 2003 for the Annex I Expert Group, which led to several publications, namely a framework paper on Institutional Capacity and Climate Actions, three national cases studies, respectively on Mexico, India and Bulgaria, as well as a paper assessing the status of national inventory preparation in Annex I and non-Annex I Parties (OECD/IEA, 2003). The paper argues that the very nature of a country's institutional development suggests a progressive approach to climate actions, which takes into account the specificity of a country's existing institutional setting. More specifically, substantial changes in a country's existing institutions are likely to be required when particular levels or types of institutional capacities need to be developed, for example when these changes affect public governance as a whole. Finally, particular forms of actions may require significant changes in a country's institutional setting. For example, legally-binding quantified national targets tend to require significant institutional development in all functions of climate policy. With other approaches, such as those based on non-binding targets, sectoral targets or policies and measures, institutional development may be more progressive and targeted. Thus, when considering particular forms of climate actions, countries might benefit from investigating what kind of institutions are likely to be needed and whether they will be able to develop sufficient capacity in time to implement these actions. Overall, this analysis suggests a step-by-step, dynamic model for

  11. Effects of walking speed on the step-by-step control of step width.

    Science.gov (United States)

    Stimpson, Katy H; Heitkamp, Lauren N; Horne, Joscelyn S; Dean, Jesse C

    2018-02-08

    Young, healthy adults walking at typical preferred speeds use step-by-step adjustments of step width to appropriately redirect their center of mass motion and ensure mediolateral stability. However, it is presently unclear whether this control strategy is retained when walking at the slower speeds preferred by many clinical populations. We investigated whether the typical stabilization strategy is influenced by walking speed. Twelve young, neurologically intact participants walked on a treadmill at a range of prescribed speeds (0.2-1.2 m/s). The mediolateral stabilization strategy was quantified as the proportion of step width variance predicted by the mechanical state of the pelvis throughout a step (calculated as R 2 magnitude from a multiple linear regression). Our ability to accurately predict the upcoming step width increased over the course of a step. The strength of the relationship between step width and pelvis mechanics at the start of a step was reduced at slower speeds. However, these speed-dependent differences largely disappeared by the end of a step, other than at the slowest walking speed (0.2 m/s). These results suggest that mechanics-dependent adjustments in step width are a consistent component of healthy gait across speeds and contexts. However, slower walking speeds may ease this control by allowing mediolateral repositioning of the swing leg to occur later in a step, thus encouraging slower walking among clinical populations with limited sensorimotor control. Published by Elsevier Ltd.

  12. Inside the Black Box: Tracking Decision-Making in an Action Research Study

    Science.gov (United States)

    Smith, Cathryn

    2017-01-01

    Action research has been described as "designing the plane while flying it" (Herr & Anderson, 2005, p. 69). A black box documented the researcher's decisions while facilitating leadership development sessions with teacher leaders. Ten process folio steps informed the study through six iterations. Planning steps included a design…

  13. Free Modal Algebras Revisited: The Step-by-Step Method

    NARCIS (Netherlands)

    Bezhanishvili, N.; Ghilardi, Silvio; Jibladze, Mamuka

    2012-01-01

    We review the step-by-step method of constructing finitely generated free modal algebras. First we discuss the global step-by-step method, which works well for rank one modal logics. Next we refine the global step-by-step method to obtain the local step-by-step method, which is applicable beyond

  14. SYSTEMATIZATION OF THE BASIC STEPS OF THE STEP-AEROBICS

    Directory of Open Access Journals (Sweden)

    Darinka Korovljev

    2011-03-01

    Full Text Available Following the development of the powerful sport industry, in front of us appeared a lot of new opportunities for creating of the new programmes of exercising with certain requisites. One of such programmes is certainly step-aerobics. Step-aerobics can be defined as a type of aerobics consisting of the basic aerobic steps (basic steps applied in exercising on stepper (step bench, with a possibility to regulate its height. Step-aerobics itself can be divided into several groups, depending on the following: type of music, working methods and adopted knowledge of the attendants. In this work, the systematization of the basic steps in step-aerobics was made on the basis of the following criteria: steps origin, number of leg motions in stepping and relating the body support at the end of the step. Systematization of the basic steps of the step-aerobics is quite significant for making a concrete review of the existing basic steps, thus making creation of the step-aerobics lesson easier

  15. Optimizing the number of steps in learning tasks for complex skills.

    Science.gov (United States)

    Nadolski, Rob J; Kirschner, Paul A; van Merriënboer, Jeroen J G

    2005-06-01

    Carrying out whole tasks is often too difficult for novice learners attempting to acquire complex skills. The common solution is to split up the tasks into a number of smaller steps. The number of steps must be optimized for efficient and effective learning. The aim of the study is to investigate the relation between the number of steps provided to learners and the quality of their learning of complex skills. It is hypothesized that students receiving an optimized number of steps will learn better than those receiving either the whole task in only one step or those receiving a large number of steps. Participants were 35 sophomore law students studying at Dutch universities, mean age=22.8 years (SD=3.5), 63% were female. Participants were randomly assigned to 1 of 3 computer-delivered versions of a multimedia programme on how to prepare and carry out a law plea. The versions differed only in the number of learning steps provided. Videotaped plea-performance results were determined, various related learning measures were acquired and all computer actions were logged and analyzed. Participants exposed to an intermediate (i.e. optimized) number of steps outperformed all others on the compulsory learning task. No differences in performance on a transfer task were found. A high number of steps proved to be less efficient for carrying out the learning task. An intermediate number of steps is the most effective, proving that the number of steps can be optimized for improving learning.

  16. Action Plan on Base Erosion and Profit Shifting: An Indian Perspective.

    OpenAIRE

    Rao, R. Kavita; Sengupta, D.P.

    2014-01-01

    The discussion in this paper highlights some evidence to support the notion that there is base erosion in India. On the specific action points listed in the OECD's Action Plan, a perspective from India's stand point has been presented along with a brief discussion on the steps needed to prepare for complying with likely proposed measures.

  17. 76 FR 19174 - State Trade and Export Promotion (STEP) Pilot Grant Program

    Science.gov (United States)

    2011-04-06

    ... Grant Program is to increase the number of small businesses that are exporting, and increase the value... SMALL BUSINESS ADMINISTRATION State Trade and Export Promotion (STEP) Pilot Grant Program AGENCY: Office of International Trade; U.S. Small Business Administration (SBA) ACTION: SBA Program Announcement...

  18. Sociodrama: Group Creative Problem Solving in Action.

    Science.gov (United States)

    Riley, John F.

    1990-01-01

    Sociodrama is presented as a structured, yet flexible, method of encouraging the use of creative thinking to examine a difficult problem. An example illustrates the steps involved in putting sociodrama into action. Production techniques useful in sociodrama include the soliloquy, double, role reversal, magic shop, unity of opposites, and audience…

  19. A Low Carbon Development Guide for Local Government Actions in China

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Nina; Zhou, Nan; Price, Lynn; Ohshita, Stephanie

    2011-05-01

    Local level actions are crucial for achieving energy-saving and greenhouse gas emission reduction targets. Yet it is challenging to implement new policies and actions due to a lack of information, funding, and capacity. This is particularly the case in developing countries such as China. Even though national energy intensity and carbon intensity targets have been set, most local governments do not have the knowledge regarding actions to achieve the targets, the cost-effectiveness of policies, the possible impact of policies, or how to design and implement a climate action plan. This paper describes a guidebook that was developed to motivate and provide local governments in China with information to create an action plan to tackle climate change and increase energy efficiency. It provides a simple step-by-step description of how action plans can be established and essential elements to be included - from preparing a GHG emission inventory to implementation of the plan. The guidebook also provides a comprehensive list of successful policies and best practices found internationally and in China to encourage low carbon development in industry, buildings, transportation, electric power generation, agriculture and forestry. This paper also presents indicators that can be used to define low-carbon development, as well as to evaluate the effectiveness of actions taken at an aggregated (city) level, and at a sectoral or end use level. The guidebook can also be used for low carbon development by local governments in other developing countries.

  20. The dependence level analysis between the human actions in NPP Operation

    International Nuclear Information System (INIS)

    Farcasiu, M.; Nitoi, M.; Apostol, M.; Florescu, G.; Prisecaru, Ilie

    2009-01-01

    The Human Reliability Analysis (HRA) is an important method in Probabilistic Safety Assessment (PSA) studies and offers desirability for concrete improvement of the man - machine - organization interfaces, reliability and safety. An important step in HRA is the dependence level analysis between the human actions performed by the same person or between the actions performed by different persons, step in quantitative analysis of the human errors probabilities. The purpose of this paper is to develop a model to analyze the dependence level between human actions for Nuclear Power Plant (NPP) operation. The model estimates the conditional human error probabilities (CHEP) and joint human error probabilities (JHEP). The achieved sensitivity analyses determine human performance sensibility to systematic variations for dependence level between human actions. The human error probabilities estimated in this paper are adequate values for integration both in HRA and in PSA realized for NPP. This type of analysis helps in finding and analyzing the ways of reducing the likelihood of human errors, so that the impact of human factor to systems availability, reliability and safety can be realistically estimated. In order to demonstrate the usability of this model an analysis is performed upon the dependences between the necessary human actions in mitigating the consequences of LOCA events, particularly for the case of Cernavoda NPP. (authors)

  1. Multi-Time Step Service Restoration for Advanced Distribution Systems and Microgrids

    International Nuclear Information System (INIS)

    Chen, Bo; Chen, Chen; Wang, Jianhui; Butler-Purry, Karen L.

    2017-01-01

    Modern power systems are facing increased risk of disasters that can cause extended outages. The presence of remote control switches (RCSs), distributed generators (DGs), and energy storage systems (ESS) provides both challenges and opportunities for developing post-fault service restoration methodologies. Inter-temporal constraints of DGs, ESS, and loads under cold load pickup (CLPU) conditions impose extra complexity on problem formulation and solution. In this paper, a multi-time step service restoration methodology is proposed to optimally generate a sequence of control actions for controllable switches, ESSs, and dispatchable DGs to assist the system operator with decision making. The restoration sequence is determined to minimize the unserved customers by energizing the system step by step without violating operational constraints at each time step. The proposed methodology is formulated as a mixed-integer linear programming (MILP) model and can adapt to various operation conditions. Furthermore, the proposed method is validated through several case studies that are performed on modified IEEE 13-node and IEEE 123-node test feeders.

  2. Steps to strengthen ethics in organizations: research findings, ethics placebos, and what works.

    Science.gov (United States)

    Pope, Kenneth S

    2015-01-01

    Research shows that many organizations overlook needs and opportunities to strengthen ethics. Barriers can make it hard to see the need for stronger ethics and even harder to take effective action. These barriers include the organization's misleading use of language, misuse of an ethics code, culture of silence, strategies of justification, institutional betrayal, and ethical fallacies. Ethics placebos tend to take the place of steps to see, solve, and prevent problems. This article reviews relevant research and specific steps that create change.

  3. How to define 'best practice' for use in Knowledge Translation research: a practical, stepped and interactive process.

    Science.gov (United States)

    Bosch, Marije; Tavender, Emma; Bragge, Peter; Gruen, Russell; Green, Sally

    2013-10-01

    Defining 'best practice' is one of the first and crucial steps in any Knowledge Translation (KT) research project. Without a sound understanding of what exactly should happen in practice, it is impossible to measure the extent of existing gaps between 'desired' and 'actual' care, set implementation goals, and monitor performance. The aim of this paper is to present a practical, stepped and interactive process to develop best practice recommendations that are actionable, locally applicable and in line with the best available research-based evidence, with a view to adapt these into process measures (quality indicators) for KT research purposes. Our process encompasses the following steps: (1) identify current, high-quality clinical practice guidelines (CPGs) and extract recommendations; (2) select strong recommendations in key clinical management areas; (3) update evidence and create evidence overviews; (4) discuss evidence and produce agreed 'evidence statements'; (5) discuss the relevance of the evidence with local stakeholders; and (6) develop locally applicable actionable best practice recommendations, suitable for use as the basis of quality indicators. Actionable definitions of local best practice are a prerequisite for doing KT research. As substantial resources go into rigorously synthesizing evidence and developing CPGs, it is important to make best use of such available resources. We developed a process for efficiently developing locally applicable actionable best practice recommendations from existing high-quality CPGs that are in line with current research evidence. © 2012 John Wiley & Sons Ltd.

  4. Energy policy implementation process : BC Hydro information session and workshop on stepped rates and access principles. draft ed.

    International Nuclear Information System (INIS)

    2003-01-01

    The government of British Columbia recognizes that some changes are needed in the energy sector to promote new investment and increase trade while maintaining low power rates and environmentally responsible energy development. BC Hydro held a workshop where several rate design parameters were presented in accordance with the Energy Plan objectives. The workshop identified some key implementation measures and invited input from customers. This paper describes 8 policy actions that will be implemented, or which are already underway to achieve objectives of the Energy Plan. Policy Action number 14 states that under the new rate structures, large electricity consumers will be able to choose a supplier other than the local distributor. Policy Action number 21 states that new rate structures will offer better price signals to large electricity consumers for conservation and energy efficiency. A new stepped rate has been proposed to implement the policy actions. The stepped rate design features different rates for different blocks of energy consumption. The stepped rate design encourages customers to invest in cost-effective conservation and self generation. The disadvantage is that customers shut down facilities and receive financial benefits as if they had invested in conservation. Customers will also continually switch back and forth between rate designs or suppliers, depending on which one provides immediate gains. It was noted that a stepped rate design requires a choice of where to place the cutoff between various Tier rates. Market options for calculating Tier 1 and Tier 2 rates were described. The three causes for reductions in energy consumption were identified as being energy efficiency, self generation, and partial or full shutdown. 4 tabs., 10 figs

  5. Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP)

    Science.gov (United States)

    Li, Hui; Li, Kang-shuai; Su, Jing; Chen, Lai-Zhong; Xu, Yun-Fei; Wang, Hong-Mei; Gong, Zheng; Cui, Guo-Ying; Yu, Xiao; Wang, Kai; Yao, Wei; Xin, Tao; Li, Min-Yong; Xiao, Kun-Hong; An, Xiao-fei; Huo, Yuqing; Xu, Zhi-gang; Sun, Jin-Peng; Pang, Qi

    2013-01-01

    Striatal-enriched tyrosine phosphatase (STEP) is an important regulator of neuronal synaptic plasticity, and its abnormal level or activity contributes to cognitive disorders. One crucial downstream effector and direct substrate of STEP is extracellular signal-regulated protein kinase (ERK), which has important functions in spine stabilisation and action potential transmission. The inhibition of STEP activity toward phospho-ERK has the potential to treat neuronal diseases, but the detailed mechanism underlying the dephosphorylation of phospho-ERK by STEP is not known. Therefore, we examined STEP activity toward pNPP, phospho-tyrosine-containing peptides, and the full-length phospho-ERK protein using STEP mutants with different structural features. STEP was found to be a highly efficient ERK tyrosine phosphatase that required both its N-terminal regulatory region and key residues in its active site. Specifically, both KIM and KIS of STEP were required for ERK interaction. In addition to the N-terminal KIS region, S245, hydrophobic residues L249/L251, and basic residues R242/R243 located in the KIM region were important in controlling STEP activity toward phospho-ERK. Further kinetic experiments revealed subtle structural differences between STEP and HePTP that affected the interactions of their KIMs with ERK. Moreover, STEP recognised specific positions of a phospho-ERK peptide sequence through its active site, and the contact of STEP F311 with phospho-ERK V205 and T207 were crucial interactions. Taken together, our results not only provide the information for interactions between ERK and STEP, but will also help in the development of specific strategies to target STEP-ERK recognition, which could serve as a potential therapy for neurological disorders. PMID:24117863

  6. Leadership Actions to Improve Nuclear Safety Culture

    International Nuclear Information System (INIS)

    Clewett, L.K.

    2016-01-01

    The challenge many leaders face is how to effectively implement and then utilise the results of Safety Culture surveys. Bruce Power has recently successfully implemented changes to the Safety Culture survey process including how corrective actions were identified and implemented. The actions taken in response to the latest survey have proven effective with step change performance noted. Nuclear Safety is a core value for Bruce Power. Nuclear Safety at Bruce Power is based on the following four pillars: reactor safety, industrial safety, radiological safety and environmental safety. Processes and practices are in place to achieve a healthy Nuclear Safety Culture within Bruce Power such that nuclear safety is the overriding priority. This governance is based on industry leading practices which monitor, asses and take action to drive continual improvements in the Nuclear Safety Culture within Bruce Power.

  7. Corticospinal excitability modulation during action observation.

    Science.gov (United States)

    Sartori, Luisa; Betti, Sonia; Castiello, Umberto

    2013-12-31

    This study used the transcranial magnetic stimulation/motor evoked potential (TMS/MEP) technique to pinpoint when the automatic tendency to mirror someone else's action becomes anticipatory simulation of a complementary act. TMS was delivered to the left primary motor cortex corresponding to the hand to induce the highest level of MEP activity from the abductor digiti minimi (ADM; the muscle serving little finger abduction) as well as the first dorsal interosseus (FDI; the muscle serving index finger flexion/extension) muscles. A neuronavigation system was used to maintain the position of the TMS coil, and electromyographic (EMG) activity was recorded from the right ADM and FDI muscles. Producing original data with regard to motor resonance, the combined TMS/MEP technique has taken research on the perception-action coupling mechanism a step further. Specifically, it has answered the questions of how and when observing another person's actions produces motor facilitation in an onlooker's corresponding muscles and in what way corticospinal excitability is modulated in social contexts.

  8. The renormalized action principle in quantum field theory

    International Nuclear Information System (INIS)

    Balasin, H.

    1990-03-01

    The renormalized action principle holds a central position in field theory, since it offers a variety of applications. The main concern of this work is the proof of the action principle within the so-called BPHZ-scheme of renormalization. Following the classical proof given by Lam and Lowenstein, some loopholes are detected and closed. The second part of the work deals with the application of the action principle to pure Yang-Mills-theories within the axial gauge (n 2 ≠ 0). With the help of the action principle we investigate the decoupling of the Faddeev-Popov-ghost-fields from the gauge field. The consistency of this procedure, suggested by three-graph approximation, is proven to survive quantization. Finally we deal with the breaking of Lorentz-symmetry caused by the presence of the gauge-direction n. Using BRST-like techniques and the semi-simplicity of the Lorentz-group, it is shown that no new breakings arise from quantization. Again the main step of the proof is provided by the action principle. (Author, shortened by G.Q.)

  9. DoD Actions Were Not Adequate to Reduce Improper Travel Payments

    Science.gov (United States)

    2016-03-10

    vouchers in near real time and identifies duplicate or incorrect payments. DoD Components developed corrective actions that did not include steps to...causes of improper payments. In addition, many of the payment errors were not preventable through real - time or post-payment automated validation checks...H 1 0 , 2 0 1 6 Report No. DODIG-2016-060 DoD Actions Were Not Adequate to Reduce Improper Travel Payments Mission Our mission is to provide

  10. Elasto-plastic benchmark calculations. Step 1: verification of the numerical accuracy of the computer programs

    International Nuclear Information System (INIS)

    Corsi, F.

    1985-01-01

    In connection with the design of nuclear reactors components operating at elevated temperature, design criteria need a level of realism in the prediction of inelastic structural behaviour. This concept leads to the necessity of developing non linear computer programmes, and, as a consequence, to the problems of verification and qualification of these tools. Benchmark calculations allow to carry out these two actions, involving at the same time an increased level of confidence in complex phenomena analysis and in inelastic design calculations. With the financial and programmatic support of the Commission of the European Communities (CEE) a programme of elasto-plastic benchmark calculations relevant to the design of structural components for LMFBR has been undertaken by those Member States which are developing a fast reactor project. Four principal progressive aims were initially pointed out that brought to the decision to subdivide the Benchmark effort in a calculations series of four sequential steps: step 1 to 4. The present document tries to summarize Step 1 of the Benchmark exercise, to derive some conclusions on Step 1 by comparison of the results obtained with the various codes and to point out some concluding comments on the first action. It is to point out that even if the work was designed to test the capabilities of the computer codes, another aim was to increase the skill of the users concerned

  11. Step dynamics and terrace-width distribution on flame-annealed gold films: The effect of step-step interaction

    International Nuclear Information System (INIS)

    Shimoni, Nira; Ayal, Shai; Millo, Oded

    2000-01-01

    Dynamics of atomic steps and the terrace-width distribution within step bunches on flame-annealed gold films are studied using scanning tunneling microscopy. The distribution is narrower than commonly observed for vicinal planes and has a Gaussian shape, indicating a short-range repulsive interaction between the steps, with an apparently large interaction constant. The dynamics of the atomic steps, on the other hand, appear to be influenced, in addition to these short-range interactions, also by a longer-range attraction of steps towards step bunches. Both types of interactions promote self-ordering of terrace structures on the surface. When current is driven through the films a step-fingering instability sets in, reminiscent of the Bales-Zangwill instability

  12. Traffic safety and step-by-step driving licence for young people

    DEFF Research Database (Denmark)

    Tønning, Charlotte; Agerholm, Niels

    2017-01-01

    presents a review of safety effects from step-by-step driving licence schemes. Most of the investigated schemes consist of a step-by-step driving licence with Step 1) various tests and education, Step 2) a period where driving is only allowed together with an experienced driver and Step 3) driving without...... companion is allowed but with various restrictions and, in some cases, additional driving education and tests. In general, a step-by-step driving licence improves traffic safety even though the young people are permitted to drive a car earlier on. The effects from driving with an experienced driver vary......Young novice car drivers are much more accident-prone than other drivers - up to 10 times that of their parents' generation. A central solution to improve the traffic safety for this group is implementation of a step-by-step driving licence. A number of countries have introduced a step...

  13. Development of the step complexity measure for emergency operating procedures using entropy concepts

    International Nuclear Information System (INIS)

    Park, Jinkyun; Jung, Wondea; Ha, Jaejoo

    2001-01-01

    For a nuclear power plant (NPP), symptom-based emergency operating procedures (EOPs) have been adopted to enhance the safety of NPPs through reduction of operators' workload under emergency conditions. Symptom-based EOPs, however, could place a workload on operators because they have to not only identify related symptoms, but also understand the context of steps that should be carried out. Therefore, many qualitative checklists are suggested to ensure the appropriateness of steps included in EOPs. However, since these qualitative evaluations have some drawbacks, a quantitative measure that can roughly estimate the complexity of EOP steps is imperative to compensate for them. In this paper, a method to evaluate the complexity of an EOP step is developed based on entropy measures that have been used in software engineering. Based on these, step complexity (SC) measure that can evaluate SC from various viewpoints (such as the amount of information/operators' actions included in each EOP step, and the logic structure of each EOP step) was developed. To verify the suitableness of the SC measure, estimated SC values are compared with subjective task load scores obtained from the NASA-TLX (task load index) method and step performance time obtained from a full scope simulator. From these comparisons, it was observed that estimated SC values generally agree with the NASA-TLX scores and step performance time data. Thus, it could be concluded that the developed SC measure would be considered for evaluating SC of an EOP step

  14. Two-step approach to the dynamics of coupled anharmonic oscillators

    International Nuclear Information System (INIS)

    Chung, N. N.; Chew, L. Y.

    2009-01-01

    We have further extended the two-step approach developed by Chung and Chew [N. N. Chung and L. Y. Chew, Phys. Rev. A 76, 032113 (2007)] to the solution of the quantum dynamics of general systems of N-coupled anharmonic oscillators. The idea is to employ an optimized basis set to represent the dynamical quantum states of these oscillator systems. The set is generated via the action of the optimized Bogoliubov transformed bosonic operators on the optimal squeezed vacuum product state. The procedure requires (i) applying the two-step approach to the eigendecomposition of the time evolution operator and (ii) transforming the representation of the initial state from the original to the optimal bases. We have applied the formalism to examine the dynamics of squeezing and entanglement of several anharmonic oscillator systems.

  15. A step-defined sedentary lifestyle index: <5000 steps/day.

    Science.gov (United States)

    Tudor-Locke, Catrine; Craig, Cora L; Thyfault, John P; Spence, John C

    2013-02-01

    Step counting (using pedometers or accelerometers) is widely accepted by researchers, practitioners, and the general public. Given the mounting evidence of the link between low steps/day and time spent in sedentary behaviours, how few steps/day some populations actually perform, and the growing interest in the potentially deleterious effects of excessive sedentary behaviours on health, an emerging question is "How many steps/day are too few?" This review examines the utility, appropriateness, and limitations of using a reoccurring candidate for a step-defined sedentary lifestyle index: 10 000) to lower (sedentary lifestyle index for adults is appropriate for researchers and practitioners and for communicating with the general public. There is little evidence to advocate any specific value indicative of a step-defined sedentary lifestyle index in children and adolescents.

  16. Diffusion coefficients for periodically induced multi-step persistent walks on regular lattices

    International Nuclear Information System (INIS)

    Gilbert, Thomas; Sanders, David P

    2012-01-01

    We present a generalization of our formalism for the computation of diffusion coefficients of multi-step persistent random walks on regular lattices to walks which include zero-displacement states. This situation is especially relevant to systems where tracer particles move across potential barriers as a result of the action of a periodic forcing whose period sets the timescale between transitions. (paper)

  17. Astronomical sketching a step-by-step introduction

    CERN Document Server

    Handy, Richard; Perez, Jeremy; Rix, Erika; Robbins, Sol

    2007-01-01

    This book presents the amateur with fine examples of astronomical sketches and step-by-step tutorials in each medium, from pencil to computer graphics programs. This unique book can teach almost anyone to create beautiful sketches of celestial objects.

  18. Impact analysis of tap switch out of step for converter transformer

    Science.gov (United States)

    Hong-yue, ZHANG; Zhen-hua, ZHANG; Zhang-xue, XIONG; Gao-wang, YU

    2017-06-01

    AC transformer load regulation is mainly used to adjust the load side voltage level, improve the quality of power supply, the voltage range is relatively narrow. In DC system, converter transformer is the core equipment of AC and DC power converter and inverter. converter transformer tap adjustment can maintain the normal operation of the converter in small angle range control, the absorption of reactive power, economic operation, valve less stress, valve damping circuit loss, AC / DC harmonic component is also smaller. In this way, the tap switch action is more frequent, and a large range of the tap switch adjustment is required. Converter transformer with a more load voltage regulation switch, the voltage regulation range of the switch is generally 20~30%, the adjustment of each file is 1%~2%. Recently it is often found that the tap switch of Converter Transformers is out of step in Converter station. In this paper, it is analyzed in detail the impact of tap switch out of step for differential protection, overexcitation protection and zero sequence over current protection. Analysis results show that: the tap switch out of step has no effect on the differential protection and the overexcitation protection including the tap switch. But the tap switch out of step has effect on zero sequence overcurrent protection of out of step star-angle converter transformer. The zero sequence overcurrent protection will trip when the tap switch out of step is greater than 3 for out of step star-angle converter transformer.

  19. Action plan for coordinated deployment of hydrogen fuel cell vehicles and hydrogen infrastructure

    International Nuclear Information System (INIS)

    Elrick, W.

    2009-01-01

    This paper discussed a program designed to provide hydrogen vehicles and accessible hydrogen stations for a pre-commercial hydrogen economy in California. The rollout will coordinate the placement of stations in areas that meet the needs of drivers in order to ensure the transition to a competitive marketplace. An action plan has been developed that focuses on the following 3 specific steps: (1) the validation of early passenger vehicle markets, (2) expanded transit bus use, and (2) the establishment of regulations and standards. Specific tasks related to the steps were discussed, as well as potential barriers to the development of a hydrogen infrastructure in California. Methods of ensuring coordinated actions with the fuel cell and hydrogen industries were also reviewed

  20. One step beyond: Different step-to-step transitions exist during continuous contact brachiation in siamangs

    Directory of Open Access Journals (Sweden)

    Fana Michilsens

    2012-02-01

    In brachiation, two main gaits are distinguished, ricochetal brachiation and continuous contact brachiation. During ricochetal brachiation, a flight phase exists and the body centre of mass (bCOM describes a parabolic trajectory. For continuous contact brachiation, where at least one hand is always in contact with the substrate, we showed in an earlier paper that four step-to-step transition types occur. We referred to these as a ‘point’, a ‘loop’, a ‘backward pendulum’ and a ‘parabolic’ transition. Only the first two transition types have previously been mentioned in the existing literature on gibbon brachiation. In the current study, we used three-dimensional video and force analysis to describe and characterize these four step-to-step transition types. Results show that, although individual preference occurs, the brachiation strides characterized by each transition type are mainly associated with speed. Yet, these four transitions seem to form a continuum rather than four distinct types. Energy recovery and collision fraction are used as estimators of mechanical efficiency of brachiation and, remarkably, these parameters do not differ between strides with different transition types. All strides show high energy recoveries (mean  = 70±11.4% and low collision fractions (mean  = 0.2±0.13, regardless of the step-to-step transition type used. We conclude that siamangs have efficient means of modifying locomotor speed during continuous contact brachiation by choosing particular step-to-step transition types, which all minimize collision fraction and enhance energy recovery.

  1. Towards Responsible Action through Agroecological Education

    Directory of Open Access Journals (Sweden)

    Geir Lieblein

    2007-06-01

    Full Text Available In the Agroecology MSc Program in the Nordic Region, conventional training of routine skills and memorizing facts, principles and theories are only two components of the educational activities.We have established a dual learning ladder metaphor to explore the expanded learning process. To establish context and build relevance, student teams begin their studies in agroecology by working with farmers and other key clients in the food system. After exploring the current situation, students can step down the learning ladder to acquire additional needed information and skills. Next they explore the links between theory and application, and we provide a safe space to experiment with putting knowledge into directed action. To help clients plan for a desirable future in farming and food systems, students step up the learning ladder to practice their ability to think creatively about the future, and then to evaluate the expected impacts and potential implications of alternative scenarios. Underlying the learning of skills, principles, and methods for action are the internal values and attitudes that will motivate and drive students in their future work. These include individual learning as a process of practicing, assimilating, connecting, creating, and acting with responsibility. In this paper we describe the educational process used in agroecology, with the dual learning ladder as metaphor for both cognitive learning and personal growth.

  2. Towards Responsible Action through Agroecological Education

    Directory of Open Access Journals (Sweden)

    Geir Lieblein

    Full Text Available In the Agroecology MSc Program in the Nordic Region, conventional training of routine skills and memorizing facts, principles and theories are only two components of the educational activities.We have established a dual learning ladder metaphor to explore the expanded learning process. To establish context and build relevance, student teams begin their studies in agroecology by working with farmers and other key clients in the food system. After exploring the current situation, students can step down the learning ladder to acquire additional needed information and skills. Next they explore the links between theory and application, and we provide a safe space to experiment with putting knowledge into directed action. To help clients plan for a desirable future in farming and food systems, students step up the learning ladder to practice their ability to think creatively about the future, and then to evaluate the expected impacts and potential implications of alternative scenarios. Underlying the learning of skills, principles, and methods for action are the internal values and attitudes that will motivate and drive students in their future work. These include individual learning as a process of practicing, assimilating, connecting, creating, and acting with responsibility. In this paper we describe the educational process used in agroecology, with the dual learning ladder as metaphor for both cognitive learning and personal growth.

  3. Application of stepping motor

    International Nuclear Information System (INIS)

    1980-10-01

    This book is divided into three parts, which is about practical using of stepping motor. The first part has six chapters. The contents of the first part are about stepping motor, classification of stepping motor, basic theory og stepping motor, characteristic and basic words, types and characteristic of stepping motor in hybrid type and basic control of stepping motor. The second part deals with application of stepping motor with hardware of stepping motor control, stepping motor control by microcomputer and software of stepping motor control. The last part mentions choice of stepping motor system, examples of stepping motor, measurement of stepping motor and practical cases of application of stepping motor.

  4. Phenomenon of political actionism in modern society

    Directory of Open Access Journals (Sweden)

    V. M. Bavykina

    2016-08-01

    analyzed the basic mechanisms of action steps identified method of subversive affirmation, deconstruction, genealogical method, which uses aktsionist in their activities. The main task of political actionism as a sociocultural phenomenon, which exists at the intersection of the political and artistic spaces. Was concluded that the political actionism is an interdisciplinary phenomenon, which should be read yak sociocultural phenomenon and investigated at an angle different disciplines – art history, sociology and philosophy.

  5. Internship guide : Work placements step by step

    NARCIS (Netherlands)

    Haag, Esther

    2013-01-01

    Internship Guide: Work Placements Step by Step has been written from the practical perspective of a placement coordinator. This book addresses the following questions : what problems do students encounter when they start thinking about the jobs their degree programme prepares them for? How do you

  6. Microsoft Office professional 2010 step by step

    CERN Document Server

    Cox, Joyce; Frye, Curtis

    2011-01-01

    Teach yourself exactly what you need to know about using Office Professional 2010-one step at a time! With STEP BY STEP, you build and practice new skills hands-on, at your own pace. Covering Microsoft Word, PowerPoint, Outlook, Excel, Access, Publisher, and OneNote, this book will help you learn the core features and capabilities needed to: Create attractive documents, publications, and spreadsheetsManage your e-mail, calendar, meetings, and communicationsPut your business data to workDevelop and deliver great presentationsOrganize your ideas and notes in one placeConnect, share, and accom

  7. Development of Stepping Endurance Test Plan on CRDM of a Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, DongHyun; Kim, Hyeonil; Park, Suki [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Various types of the irradiation targets can be loaded and unloaded during power operation, according to the purpose of research reactor utilization. And their reactivity worth varies as well. The insertion rate of reactivity is dependent to reactivity worth of targets, travel length during loading or unloading and transfer device speed. Due to the reactivity transition during loading and unloading, neutron power is changed and reaches an action point of the reactor regulating system. Based on the measured neutron rate of change, reactor power control system controls the power with its own algorithm. It generates the signals and transmits these to the CRDM for motor driving. Stepping motors on the CRDM move the control rods with step signals. The process repeats until power is stabilized. Accordingly, the stepping behaviours of CRDM should be modelled upon an understanding of the control process and reactor responses. Methodology for a stepping endurance test plan on the CRDM of a research reactor is developed since CRDM endurance is very important for reactor controller and should be ensured for a certain period of time throughout the life of a research reactor. Therefore, it is expected to provide a reasonable stepping test plan. In the future, the simulation will be performed with specific design values.

  8. Trends and problems in marital and family therapy research: Possible use of action research

    Directory of Open Access Journals (Sweden)

    Robert Cvetek

    2006-03-01

    Full Text Available Although research in marital and family therapy (MFT is becoming increasingly important, it continues to encounter several major problems. Studies have shown that research has very little influence on the practice of the majority of MFT practitioners. Practitioners see research as unrelated to their concerns. The practice of the majority of MFT practitioners is very individualized, as are the clinical problems and circumstances. Some have therefore started to emphasize the transferability of results instead of generalizability, and studying the practitioner's own practice instead of general concepts. Action research in the field of psychotherapy, as well as in the field of MFT, has been mainly overlooked as a potential method for solving these problems in MFT research. The paper addresses one of many possible ways to use the repeating cycles of the four basic steps in action research (observing and gathering information, reflecting, planning, and acting. The use of these four steps in action research enables therapists to study and improve their own practice in a more systematic, structured, and valid manner. This kind of research connects research and therapy. It is very individualized and oriented towards actions that create therapeutic changes.

  9. Data-Based Predictive Control with Multirate Prediction Step

    Science.gov (United States)

    Barlow, Jonathan S.

    2010-01-01

    Data-based predictive control is an emerging control method that stems from Model Predictive Control (MPC). MPC computes current control action based on a prediction of the system output a number of time steps into the future and is generally derived from a known model of the system. Data-based predictive control has the advantage of deriving predictive models and controller gains from input-output data. Thus, a controller can be designed from the outputs of complex simulation code or a physical system where no explicit model exists. If the output data happens to be corrupted by periodic disturbances, the designed controller will also have the built-in ability to reject these disturbances without the need to know them. When data-based predictive control is implemented online, it becomes a version of adaptive control. One challenge of MPC is computational requirements increasing with prediction horizon length. This paper develops a closed-loop dynamic output feedback controller that minimizes a multi-step-ahead receding-horizon cost function with multirate prediction step. One result is a reduced influence of prediction horizon and the number of system outputs on the computational requirements of the controller. Another result is an emphasis on portions of the prediction window that are sampled more frequently. A third result is the ability to include more outputs in the feedback path than in the cost function.

  10. The way to collisions, step by step

    CERN Multimedia

    2009-01-01

    While the LHC sectors cool down and reach the cryogenic operating temperature, spirits are warming up as we all eagerly await the first collisions. No reason to hurry, though. Making particles collide involves the complex manoeuvring of thousands of delicate components. The experts will make it happen using a step-by-step approach.

  11. Action Research in Landscape Ecology (Šumava Biosphere Reserve, Czech Republic Case Study

    Directory of Open Access Journals (Sweden)

    Kušová Drahomíra

    2017-12-01

    Full Text Available Current landscape ecological research applies trans-disciplinarity as a principle when considering the study of landscape as a multifunctional entity. The principle can be practically applied by use of participatory action research. The paper reports on the use of participatory action research in the process of step-by-step institutionalization of the Šumava Biosphere Reserve, as a complement to the state-conducted nature conservation, which took place in the period 1991−2016. To briefly summarize the main findings, we can suggest that the present institutional model of the Šumava Biosphere Reserve emerged primarily thanks to the ‘permanent jointly conducted experiment’ that followed the spiral scheme of action research, in which outputs of one implementation project served as a starting point to formulate, and subsequently realize the follow-up projects(s. The local community was engaged in the whole process, hence lessons learned became a part of local social and cultural capital, which since can be considered important endogenous developmental potential of the region.

  12. Performance driven IT management five practical steps to business success

    CERN Document Server

    Sachs, Ira

    2011-01-01

    This book argues that the Federal Government needs a new approach to IT management. Introducing a novel five-step process called performance-driven management (PDM), author Ira Sachs explains in detail how to reduce risk on large IT programs and projects. This is an essential tool for all IT and business managers in government and contractors doing business with the government, and it has much useful and actionable information for anyone who is interested in helping their business save money and take on effective, successful practices.

  13. Assessing Changes in Job Behavior Due to Training: A Guide to the Participant Action Plan Approach.

    Science.gov (United States)

    Office of Personnel Management, Washington, DC.

    This guide provides a brief introduction to the Participant Action Plan Approach (PAPA) and a user's handbook. Part I outlines five steps of PAPA which determine how job behavior is changed by training course or program participation. Part II, the manual, is arranged by the five steps of the PAPA approach. Planning for PAPA discusses making…

  14. Animated pose templates for modeling and detecting human actions.

    Science.gov (United States)

    Yao, Benjamin Z; Nie, Bruce X; Liu, Zicheng; Zhu, Song-Chun

    2014-03-01

    This paper presents animated pose templates (APTs) for detecting short-term, long-term, and contextual actions from cluttered scenes in videos. Each pose template consists of two components: 1) a shape template with deformable parts represented in an And-node whose appearances are represented by the Histogram of Oriented Gradient (HOG) features, and 2) a motion template specifying the motion of the parts by the Histogram of Optical-Flows (HOF) features. A shape template may have more than one motion template represented by an Or-node. Therefore, each action is defined as a mixture (Or-node) of pose templates in an And-Or tree structure. While this pose template is suitable for detecting short-term action snippets in two to five frames, we extend it in two ways: 1) For long-term actions, we animate the pose templates by adding temporal constraints in a Hidden Markov Model (HMM), and 2) for contextual actions, we treat contextual objects as additional parts of the pose templates and add constraints that encode spatial correlations between parts. To train the model, we manually annotate part locations on several keyframes of each video and cluster them into pose templates using EM. This leaves the unknown parameters for our learning algorithm in two groups: 1) latent variables for the unannotated frames including pose-IDs and part locations, 2) model parameters shared by all training samples such as weights for HOG and HOF features, canonical part locations of each pose, coefficients penalizing pose-transition and part-deformation. To learn these parameters, we introduce a semi-supervised structural SVM algorithm that iterates between two steps: 1) learning (updating) model parameters using labeled data by solving a structural SVM optimization, and 2) imputing missing variables (i.e., detecting actions on unlabeled frames) with parameters learned from the previous step and progressively accepting high-score frames as newly labeled examples. This algorithm belongs to a

  15. Guam Energy Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    Conrad, M. D.; Ness, J. E.

    2013-07-01

    Describes the four near-term strategies selected by the Guam Energy Task Force during action planning workshops conducted in March 2013, and outlines the steps being taken to implement those strategies. Each strategy addresses one of the energy sectors identified in the earlier Guam strategic energy plan as being an essential component of diversifying Guam's fuel sources and reducing fossil energy consumption 20% by 2020. The four energy strategies selected are: (1) expanding public outreach on energy efficiency and conservation, (2) establishing a demand-side management revolving loan program, (3) exploring waste-to-energy options, and (4) influencing the transportation sector via anti-idling legislation, vehicle registration fees, and electric vehicles.

  16. MANAGEMENT OF RENEWABLE ENERGY AND REGIONAL DEVELOPMENT: EUROPEAN EXPERIENCES AND STEPS FORWARD

    OpenAIRE

    Andreea Ileana Zamfir

    2011-01-01

    The issues of the renewable energy and regional development have become major priorities for public policymakers across the globe. Therefore, this study explores some European experiences and steps forward in the field of the management of renewable energy and regional development. Firstly, an overview of renewable energy issues in European regions is revealed, and secondly, some measures and actions for managing regional development of renewable energy in Romania taking into account the fina...

  17. Objects Mediate Goal Integration in Ventrolateral Prefrontal Cortex during Action Observation.

    Directory of Open Access Journals (Sweden)

    Mari Hrkać

    Full Text Available Actions performed by others are mostly not observed in isolation, but embedded in sequences of actions tied together by an overarching goal. Therefore, preceding actions can modulate the observer's expectations in relation to the currently perceived action. Ventrolateral prefrontal cortex (vlPFC, and inferior frontal gyrus (IFG in particular, is suggested to subserve the integration of episodic as well as semantic information and memory, including action scripts. The present fMRI study investigated if activation in IFG varies with the effort to integrate expected and observed action, even when not required by the task. During an fMRI session, participants were instructed to attend to short videos of single actions and to deliver a judgment about the actor's current goal. We manipulated the strength of goal expectation induced by the preceding action, implementing the parameter "goal-relatedness" between the preceding and the currently observed action. Moreover, since objects point to the probability of certain actions, we also manipulated whether the current and the preceding action shared at least one object or not. We found an interaction between the two factors goal-relatedness and shared object: IFG activation increased the weaker the goal-relatedness between the preceding and the current action was, but only when they shared at least one object. Here, integration of successive action steps was triggered by the re-appearing (shared object but hampered by a weak goal-relatedness between the actually observed manipulation. These findings foster the recently emerging view that IFG is enhanced by goal-related conflicts during action observation.

  18. The Value of Step-by-Step Risk Assessment for Unmanned Aircraft

    DEFF Research Database (Denmark)

    La Cour-Harbo, Anders

    2018-01-01

    The new European legislation expected in 2018 or 2019 will introduce a step-by-step process for conducting risk assessments for unmanned aircraft flight operations. This is a relatively simple approach to a very complex challenge. This work compares this step-by-step process to high fidelity risk...... modeling, and shows that at least for a series of example flight missions there is reasonable agreement between the two very different methods....

  19. The Step Method - Battling Identity Theft Using E-Retailers' Websites

    Science.gov (United States)

    Schulze, Marion; Shah, Mahmood H.

    Identity theft is the fastest growing crime in the 21st century. This paper investigates firstly what well-known e-commerce organizations are communicating on their websites to address this issue. For this purpose we analyze secondary data (literature and websites of ten organizations). Secondly we investigate the good practice in this area and recommend practical steps. The key findings are that some organizations only publish minimum security information to comply with legal requirements. Others inform consumers on how they actively try to prevent identity theft, how consumers can protect themselves, and about supporting actions when identity theft related fraud actually happens. From these findings we developed the Support - Trust - Empowerment -Prevention (STEP) method. It is aimed at helping to prevent identity theft and dealing with consequences when it occurs. It can help organizations on gaining and keeping consumers’ trust which is so essential for e-retailers in a climate of rising fraud.

  20. Determination of Sintered (Th,U)O2 Pellet at the Grain Growth Step

    International Nuclear Information System (INIS)

    Indrati-Y, Tundjung; Pristi-Hartati, Murdani; Ari-Handayani; Ginting, Aslina Br

    2000-01-01

    The determination of sintered (Th,U)O 2 pellet at the grain growth stephave been done by dilatometer and Scanning Electron Microscope (SEM). Thecalculation method based on the densification curve and quantitativemetallurgy. The green pellet be produced by single action compaction. Itspellet was heated on the dilatometer with heating rate 11 o C/minute and inthe argon atmosphere, 2 liters/hour. The activation energy at thedensification step can be calculated by densification curve only, but theactivation energy at the grain growth step can be calculated by densificationcurve or quantitative metallurgy. The capability of the dilatometer can beoperated until 1200 o C, so the densification curve based on the experiencecan be used to calculate activation energy at the densification step, 4.492kcal/mole. The activation energy at the grain growth step, which is 25.277kcal/mole, can be predicted by trial and error on n value. That activationenergy is almost the same with activation energy that based on thequantitative metallurgy method 25.042 kcal/mole. All of the activation energyfor the (Th,U)O 2 pellet sintering process is 29.769 kcal/mole. (author)

  1. Inter-RMO Key Comparison EUROMET.L-K5.2004: Calibration of a step gauge

    DEFF Research Database (Denmark)

    Prieto, Emilio; Brown, Nicholas; Lassila, Antti

    2012-01-01

    The results of the inter-RMO key comparison EUROMET.L-K5.2004 on the calibration of a step gauge are reported. Eighteen National Metrology Institutes and one Designated Institute from four different metrological regions all over the world participated in this comparison which lasted three years...... value. Due to the significant instability of the step it was also considered an artefact uncertainty. The reported uncertainties ranged from 0.045 µm to 1.2 µm (k = 1). The uncertainty of the artefact ranged from 0.018 µm (for the 20 mm face) to 0.176 µm (for the 400 mm face). The compatibility of all...... participants for measuring step gauges was demonstrated with the only exception of a participant showing very high systematic (both positive and negative) errors. Five participants communicated higher uncertainties than the corresponding approved CMCs. A set of Recommendations and Actions were agreed therefore...

  2. Linking perception and action by structure or process? Toward an integrative perspective.

    Science.gov (United States)

    Herwig, Arvid

    2015-05-01

    Over the past decades cognitive neuroscience's renewed interest in action has intensified the search of principles explaining how the cognitive system links perception to action and vice versa. To date, at least two seemingly alternative approaches can be distinguished. Perception and action might be linked either by common representational structures, as assumed by the ideomotor approach, or by common attentional processes, as assumed by the attention approach. This article first reviews the evidence from different paradigms supporting each approach. It becomes clear that most studies selectively focus either on actions directed at goals outside the actors' perceptual range (supporting the ideomotor approach) or on actions directed at targets within the actors' perceptual range (supporting the attention approach). In a second step, I will try to reconcile both approaches by reviewing recent eye movement studies that abolish the classical combination of approach and goals under study. Demonstrating that both approaches cover target- as well as goal-directed actions, it is proposed that operations addressed in both conceptual frameworks interact with each other. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Corrective Action Investigation Plan for Corrective Action Unit 554: Area 23 Release Site, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    Boehlecke, Robert F.

    2004-01-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information for conducting site investigation activities at Corrective Action Unit (CAU) 554: Area 23 Release Site, Nevada Test Site, Nevada. Information presented in this CAIP includes facility descriptions, environmental sample collection objectives, and criteria for the selection and evaluation of environmental samples. Corrective Action Unit 554 is located in Area 23 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 554 is comprised of one Corrective Action Site (CAS), which is: 23-02-08, USTs 23-115-1, 2, 3/Spill 530-90-002. This site consists of soil contamination resulting from a fuel release from underground storage tanks (USTs). Corrective Action Site 23-02-08 is being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation prior to evaluating corrective action alternatives and selecting the appropriate corrective action for this CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document for CAU 554. Corrective Action Site 23-02-08 will be investigated based on the data quality objectives (DQOs) developed on July 15, 2004, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; and contractor personnel. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 554. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to CAS 23-02-08. The scope of the corrective action investigation

  4. DFT/B3LYP study of tocopherols and chromans antioxidant action energetics

    International Nuclear Information System (INIS)

    Klein, Erik; Lukes, Vladimir; Ilcin, Michal

    2007-01-01

    Gas-phase reaction enthalpies related to the individual steps of three phenolic antioxidants action mechanisms - hydrogen atom transfer (HAT), single-electron transfer-proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET) for four tocopherols and seven chromans - were calculated using DFT/B3LYP method. For α-tocopherol, one of the chromans and phenol, reaction enthalpies in water were computed. In comparison to gas phase, water causes severe changes in the energetics of studied compounds antioxidant action. From the thermodynamic point of view, entering SPLET mechanism represents the most probable process in water

  5. DFT/B3LYP study of tocopherols and chromans antioxidant action energetics

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Erik [Institute of Physical Chemistry and Chemical Physics, Slovak University of Technology, Radlinskeho 9, SK-812 37 Bratislava (Slovakia)], E-mail: erik.klein@stuba.sk; Lukes, Vladimir; Ilcin, Michal [Institute of Physical Chemistry and Chemical Physics, Slovak University of Technology, Radlinskeho 9, SK-812 37 Bratislava (Slovakia)

    2007-07-09

    Gas-phase reaction enthalpies related to the individual steps of three phenolic antioxidants action mechanisms - hydrogen atom transfer (HAT), single-electron transfer-proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET) for four tocopherols and seven chromans - were calculated using DFT/B3LYP method. For {alpha}-tocopherol, one of the chromans and phenol, reaction enthalpies in water were computed. In comparison to gas phase, water causes severe changes in the energetics of studied compounds antioxidant action. From the thermodynamic point of view, entering SPLET mechanism represents the most probable process in water.

  6. Step-by-Step Visual Manuals: Design and Development

    Science.gov (United States)

    Urata, Toshiyuki

    2004-01-01

    The types of handouts and manuals that are used in technology training vary. Some describe procedures in a narrative way without graphics; some employ step-by-step instructions with screen captures. According to Thirlway (1994), a training manual should be like a tutor that permits a student to learn at his own pace and gives him confidence for…

  7. Neurons in primary motor cortex engaged during action observation.

    Science.gov (United States)

    Dushanova, Juliana; Donoghue, John

    2010-01-01

    Neurons in higher cortical areas appear to become active during action observation, either by mirroring observed actions (termed mirror neurons) or by eliciting mental rehearsal of observed motor acts. We report the existence of neurons in the primary motor cortex (M1), an area that is generally considered to initiate and guide movement performance, responding to viewed actions. Multielectrode recordings in monkeys performing or observing a well-learned step-tracking task showed that approximately half of the M1 neurons that were active when monkeys performed the task were also active when they observed the action being performed by a human. These 'view' neurons were spatially intermingled with 'do' neurons, which are active only during movement performance. Simultaneously recorded 'view' neurons comprised two groups: approximately 38% retained the same preferred direction (PD) and timing during performance and viewing, and the remainder (62%) changed their PDs and time lag during viewing as compared with performance. Nevertheless, population activity during viewing was sufficient to predict the direction and trajectory of viewed movements as action unfolded, although less accurately than during performance. 'View' neurons became less active and contained poorer representations of action when only subcomponents of the task were being viewed. M1 'view' neurons thus appear to reflect aspects of a learned movement when observed in others, and form part of a broadly engaged set of cortical areas routinely responding to learned behaviors. These findings suggest that viewing a learned action elicits replay of aspects of M1 activity needed to perform the observed action, and could additionally reflect processing related to understanding, learning or mentally rehearsing action.

  8. Preparing for the European Championships: A six-step mental skills training program in disability sports

    DEFF Research Database (Denmark)

    Larsen, Carsten Hvid

    2014-01-01

    with the woman's national goalball team in Denmark (high-performance athletes with visual impairment). The author provides a detailed description of six steps from initiation of the program, group sessions, and action plans, to on-court training and evaluation of the program across six months, and finishes......This article presents a case example and six-step mental-skills training program for high-performance athletes in disability sports. Starting out with a basic description about applied sport psychology in disability sports, the author proceeds to describe the mental skills training program...... with reviewing coach and player reflections on the application of the mental-skills training program....

  9. Hydrogen with intrinsic CO{sub 2} sequestration: the ENI 'One Step Hydrogen' process

    Energy Technology Data Exchange (ETDEWEB)

    Rossini, S.; Cornaro, U.; Mizia, F.; Malandrino, A.; Piccoli, V. [Enitecnologie SpA, S. Donata Milanese (Italy); Sanfilippo, D.; Miracca, I. [Snamprogetti SpA, S. Donato Milanese (Italy)

    2003-07-01

    The new process, under development in our companies, is aimed to hydrogen production with intrinsic carbon dioxide sequestration. This is made possible combining in a cycle the water oxidative potential with a reverse action by a reducing agent like hydrocarbons, the preferred being natural gas. In the first step a suitable oxide takes up the oxygen from water splitting producing hydrogen. The solid act as an oxygen storage medium. Such 'lattice' oxygen is in turn released through one or more elemental steps. The process fits very well with a circulating fluid bed reactor which allows the movement of the solid from one reactive environment to the other. (orig.)

  10. Performance of an attention-demanding task during treadmill walking shifts the noise qualities of step-to-step variation in step width.

    Science.gov (United States)

    Grabiner, Mark D; Marone, Jane R; Wyatt, Marilynn; Sessoms, Pinata; Kaufman, Kenton R

    2018-06-01

    The fractal scaling evident in the step-to-step fluctuations of stepping-related time series reflects, to some degree, neuromotor noise. The primary purpose of this study was to determine the extent to which the fractal scaling of step width, step width and step width variability are affected by performance of an attention-demanding task. We hypothesized that the attention-demanding task would shift the structure of the step width time series toward white, uncorrelated noise. Subjects performed two 10-min treadmill walking trials, a control trial of undisturbed walking and a trial during which they performed a mental arithmetic/texting task. Motion capture data was converted to step width time series, the fractal scaling of which were determined from their power spectra. Fractal scaling decreased by 22% during the texting condition (p Step width and step width variability increased 19% and five percent, respectively (p step width fractal scaling. The change of the fractal scaling of step width is consistent with increased cognitive demand and suggests a transition in the characteristics of the signal noise. This may reflect an important advance toward the understanding of the manner in which neuromotor noise contributes to some types of falls. However, further investigation of the repeatability of the results, the sensitivity of the results to progressive increases in cognitive load imposed by attention-demanding tasks, and the extent to which the results can be generalized to the gait of older adults seems warranted. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. Effect of One-Step and Multi-Steps Polishing System on Enamel Roughness

    Directory of Open Access Journals (Sweden)

    Cynthia Sumali

    2013-07-01

    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 The final procedures of orthodontic treatment are bracket debonding and cleaning the remaining adhesive. Multi-step polishing system is the most common method used. The disadvantage of that system is long working time, because of the stages that should be done. Therefore, dental material manufacturer make an improvement to the system, to reduce several stages into one stage only. This new system is known as one-step polishing system. Objective: To compare the effect of one-step and multi-step polishing system on enamel roughness after orthodontic bracket debonding. Methods: Randomized control trial was conducted included twenty-eight maxillary premolar randomized into two polishing system; one-step OptraPol (Ivoclar, Vivadent and multi-step AstroPol (Ivoclar, Vivadent. After bracket debonding, the remaining adhesive on each group was cleaned by subjective polishing system for ninety seconds using low speed handpiece. The enamel roughness was subjected to profilometer, registering two roughness parameters (Ra, Rz. Independent t-test was used to analyze the mean score of enamel roughness in each group. Results: There was no significant difference of enamel roughness between one-step and multi-step polishing system (p>0.005. Conclusion: One-step polishing system can produce a similar enamel roughness to multi-step polishing system after bracket debonding and adhesive cleaning.DOI: 10.14693/jdi.v19i3.136

  12. Building a Tower of Babel? Integrating Core Motivations and Features of Social Structure into the Political Psychology of Political Action

    NARCIS (Netherlands)

    van Zomeren, Martijn

    The political psychology of political action provides the potential for building bridges between scholars from different fields. The main aim of this article is to set some baby steps toward building two conceptual bridges by bringing together a core motivation approach to political action with core

  13. Survey of advanced practice registered nurses disciplinary action.

    Science.gov (United States)

    Hudspeth, Randall

    2007-04-02

    The nursing profession continues to struggle to find the most appropriate approach to credentialing Advanced Practice Registered Nurses (APRNs). One early step in addressing this struggle is determining the incidence of APRN disciplinary actions by boards of nursing. This article presents data from 2003 and 2004 describing the incidence of APRN disciplinary actions by United States boards of nursing. Fifty-one boards of nursing, all members of the National Council of State Boards of Nursing, were asked to report the numbers of APRN discipline cases for 2003 and 2004 which had been resolved, using a tool that differentiated disciplinary cases into four data categories: chemical impairment, exceeding scope of practice, unprofessional conduct, and safety or abuse of patients. Thirty-eight (74.5%) of 51 boards of nursing reported discipline data for a total of 125,882 APRNs showing 688 disciplinary actions were taken during 2003 and 2004. This indicates that APRNs experience a low incidence of discipline related to chemical impairment, exceeding scope of practice, unprofessional conduct, and safety or abuse of patients.

  14. Covariant and background independent functional RG flow for the effective average action

    Energy Technology Data Exchange (ETDEWEB)

    Safari, Mahmoud; Vacca, Gian Paolo [Dipartimento di Fisica and INFN - Sezione di Bologna,via Irnerio 46, 40126 Bologna (Italy)

    2016-11-23

    We extend our prescription for the construction of a covariant and background-independent effective action for scalar quantum field theories to the case where momentum modes below a certain scale are suppressed by the presence of an infrared regulator. The key step is an appropriate choice of the infrared cutoff for which the Ward identity, capturing the information from single-field dependence of the ultraviolet action, continues to be exactly solvable, and therefore, in addition to covariance, manifest background independence of the effective action is guaranteed at any scale. A practical consequence is that in this framework one can adopt truncations dependent on the single total field. Furthermore we discuss the necessary and sufficient conditions for the preservation of symmetries along the renormalization group flow.

  15. Microsoft® Visual Basic® 2010 Step by Step

    CERN Document Server

    Halvorson, Michael

    2010-01-01

    Your hands-on, step-by-step guide to learning Visual Basic® 2010. Teach yourself the essential tools and techniques for Visual Basic® 2010-one step at a time. No matter what your skill level, you'll find the practical guidance and examples you need to start building professional applications for Windows® and the Web. Discover how to: Work in the Microsoft® Visual Studio® 2010 Integrated Development Environment (IDE)Master essential techniques-from managing data and variables to using inheritance and dialog boxesCreate professional-looking UIs; add visual effects and print supportBuild com

  16. Using Aspen plus in thermodynamics instruction a step-by-step guide

    CERN Document Server

    Sandler, Stanley I

    2015-01-01

    A step-by-step guide for students (and faculty) on the use of Aspen in teaching thermodynamics Used for a wide variety of important engineering tasks, Aspen Plus software is a modeling tool used for conceptual design, optimization, and performance monitoring of chemical processes. After more than twenty years, it remains one of the most popular and powerful chemical engineering simulation programs used both industrially and academically. Using Aspen Plus in Thermodynamics Instruction: A Step by Step Guide introduces the reader to the use of Aspen Plus in courses in thermodynamics. It prov

  17. Space Weather Action Plan Solar Radio Burst Phase 1 Benchmarks and the Steps to Phase 2

    Science.gov (United States)

    Biesecker, D. A.; White, S. M.; Gopalswamy, N.; Black, C.; Love, J. J.; Pierson, J.

    2017-12-01

    Solar radio bursts, when at the right frequency and when strong enough, can interfere with radar, communication, and tracking signals. In severe cases, radio bursts can inhibit the successful use of radio communications and disrupt a wide range of systems that are reliant on Position, Navigation, and Timing services on timescales ranging from minutes to hours across wide areas on the dayside of Earth. The White House's Space Weather Action Plan asked for solar radio burst intensity benchmarks for an event occurrence frequency of 1 in 100 years and also a theoretical maximum intensity benchmark. The benchmark team has developed preliminary (phase 1) benchmarks for the VHF (30-300 MHz), UHF (300-3000 MHz), GPS (1176-1602 MHz), F10.7 (2800 MHz), and Microwave (4000-20000) bands. The preliminary benchmarks were derived based on previously published work. Limitations in the published work will be addressed in phase 2 of the benchmark process. In addition, deriving theoretical maxima requires additional work, where it is even possible to, in order to meet the Action Plan objectives. In this presentation, we will present the phase 1 benchmarks, the basis used to derive them, and the limitations of that work. We will also discuss the work that needs to be done to complete the phase 2 benchmarks.

  18. The NIST Step Class Library (Step Into the Future)

    Science.gov (United States)

    1990-09-01

    Figure 6. Excerpt from a STEP exclange file based on the Geometry model 1be NIST STEP Class Libary Page 13 An issue of concern in this...Scheifler, R., Gettys, J., and Newman, P., X Window System: C Library and Protocol Reference. Digital Press, Bedford, Mass, 1988. [Schenck90] Schenck, D

  19. Valve cam design using numerical step-by-step method

    OpenAIRE

    Vasilyev, Aleksandr; Bakhracheva, Yuliya; Kabore, Ousman; Zelenskiy, Yuriy

    2014-01-01

    This article studies the numerical step-by-step method of cam profile design. The results of the study are used for designing the internal combustion engine valve gear. This method allows to profile the peak efficiency of cams in view of many restrictions, connected with valve gear serviceability and reliability.

  20. The Central Nervous System Sites Mediating the Orexigenic Actions of Ghrelin

    Science.gov (United States)

    Mason, B.L.; Wang, Q.; Zigman, J.M.

    2014-01-01

    The peptide hormone ghrelin is important for both homeostatic and hedonic eating behaviors, and its orexigenic actions occur mainly via binding to the only known ghrelin receptor, the growth hormone secretagogue receptor (GHSR). GHSRs are located in several distinct regions of the central nervous system. This review discusses those central nervous system sites that have been found to play critical roles in the orexigenic actions of ghrelin, including hypothalamic nuclei, the hippocampus, the amygdala, the caudal brain stem, and midbrain dopaminergic neurons. Hopefully, this review can be used as a stepping stone for the reader wanting to gain a clearer understanding of the central nervous system sites of direct ghrelin action on feeding behavior, and as inspiration for future studies to provide an even-more-detailed map of the neurocircuitry controlling eating and body weight. PMID:24111557

  1. Corrective Action Investigation Plan for Corrective Action Unit 166: Storage Yards and Contaminated Materials, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    David Strand

    2006-01-01

    contaminants of concern are present. (5) If contaminants of concern are present, collect additional step-out samples to define the extent of the contamination. (6) Collect samples of investigation-derived waste, as needed, for waste management and minimization purposes. This Corrective Action Investigation Plan has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' that was agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. Under the ''Federal Facility Agreement and Consent Order'', this Corrective Action Investigation Plan will be submitted to the Nevada Division of Environmental Protection, and field work will commence following approval

  2. Cellobiohydrolase 1 from Trichoderma reesei degrades cellulose in single cellobiose steps

    Science.gov (United States)

    Brady, Sonia K.; Sreelatha, Sarangapani; Feng, Yinnian; Chundawat, Shishir P. S.; Lang, Matthew J.

    2015-12-01

    Cellobiohydrolase 1 from Trichoderma reesei (TrCel7A) processively hydrolyses cellulose into cellobiose. Although enzymatic techniques have been established as promising tools in biofuel production, a clear understanding of the motor's mechanistic action has yet to be revealed. Here, we develop an optical tweezers-based single-molecule (SM) motility assay for precision tracking of TrCel7A. Direct observation of motility during degradation reveals processive runs and distinct steps on the scale of 1 nm. Our studies suggest TrCel7A is not mechanically limited, can work against 20 pN loads and speeds up when assisted. Temperature-dependent kinetic studies establish the energy requirements for the fundamental stepping cycle, which likely includes energy from glycosidic bonds and other sources. Through SM measurements of isolated TrCel7A domains, we determine that the catalytic domain alone is sufficient for processive motion, providing insight into TrCel7A's molecular motility mechanism.

  3. Leading Change Step-by-Step: Tactics, Tools, and Tales

    Science.gov (United States)

    Spiro, Jody

    2010-01-01

    "Leading Change Step-by-Step" offers a comprehensive and tactical guide for change leaders. Spiro's approach has been field-tested for more than a decade and proven effective in a wide variety of public sector organizations including K-12 schools, universities, international agencies and non-profits. The book is filled with proven tactics for…

  4. Corrective Action Investigation Plan for Corrective Action Unit 190: Contaminated Waste Sites Nevada Test Site, Nevada, Rev. No.: 0

    International Nuclear Information System (INIS)

    Wickline, Alfred

    2006-01-01

    Corrective Action Unit (CAU) 190 is located in Areas 11 and 14 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 190 is comprised of the four Corrective Action Sites (CASs) listed below: (1) 11-02-01, Underground Centrifuge; (2) 11-02-02, Drain Lines and Outfall; (3) 11-59-01, Tweezer Facility Septic System; and (4) 14-23-01, LTU-6 Test Area. These sites are being investigated because existing information is insufficient on the nature and extent of potential contamination to evaluate and recommend corrective action alternatives. Additional information will be obtained before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS by conducting a corrective action investigation (CAI). The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on August 24, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture, and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 190. The scope of the CAU 190 CAI includes the following activities: (1) Move surface debris and/or materials, as needed, to facilitate sampling; (2) Conduct radiological and geophysical surveys; (3) Perform field screening; (4) Collect and submit environmental samples for laboratory analysis to determine whether contaminants of concern (COCs) are present; (5) If COCs are present, collect additional step-out samples to define the lateral and vertical extent of the contamination; (6) Collect samples of source material, if present

  5. Call to Action: The Case for Advancing Disaster Nursing Education in the United States.

    Science.gov (United States)

    Veenema, Tener Goodwin; Lavin, Roberta Proffitt; Griffin, Anne; Gable, Alicia R; Couig, Mary Pat; Dobalian, Aram

    2017-11-01

    Climate change, human conflict, and emerging infectious diseases are inexorable actors in our rapidly evolving healthcare landscape that are triggering an ever-increasing number of disaster events. A global nursing workforce is needed that possesses the knowledge, skills, and abilities to respond to any disaster or large-scale public health emergency in a timely and appropriate manner. The purpose of this article is to articulate a compelling mandate for the advancement of disaster nursing education within the United States with clear action steps in order to contribute to the achievement of this vision. A national panel of invited disaster nursing experts was convened through a series of monthly semistructured conference calls to work collectively towards the achievement of a national agenda for the future of disaster nursing education. National nursing education experts have developed consensus recommendations for the advancement of disaster nursing education in the United States. This article proposes next steps and action items to achieve the desired vision of national nurse readiness. Novel action steps for expanding disaster educational opportunities across the continuum of nursing are proposed in response to the current compelling need to prepare for, respond to, and mitigate the impact of disasters on human health. U.S. educational institutions and health and human service organizations that employ nurses must commit to increasing access to a variety of quality disaster-related educational programs for nurses and nurse leaders. Opportunities exist to strengthen disaster readiness and enhance national health security by expanding educational programming and training for nurses. © 2017 Sigma Theta Tau International.

  6. Microsoft Office Word 2007 step by step

    CERN Document Server

    Cox, Joyce

    2007-01-01

    Experience learning made easy-and quickly teach yourself how to create impressive documents with Word 2007. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them!Apply styles and themes to your document for a polished lookAdd graphics and text effects-and see a live previewOrganize information with new SmartArt diagrams and chartsInsert references, footnotes, indexes, a table of contentsSend documents for review and manage revisionsTurn your ideas into blogs, Web pages, and moreYour all-in-one learning experience includes:Files for building sk

  7. Step by Step Microsoft Office Visio 2003

    CERN Document Server

    Lemke, Judy

    2004-01-01

    Experience learning made easy-and quickly teach yourself how to use Visio 2003, the Microsoft Office business and technical diagramming program. With STEP BY STEP, you can take just the lessons you need, or work from cover to cover. Either way, you drive the instruction-building and practicing the skills you need, just when you need them! Produce computer network diagrams, organization charts, floor plans, and moreUse templates to create new diagrams and drawings quicklyAdd text, color, and 1-D and 2-D shapesInsert graphics and pictures, such as company logosConnect shapes to create a basic f

  8. Intrinsically motivated action-outcome learning and goal-based action recall: a system-level bio-constrained computational model.

    Science.gov (United States)

    Baldassarre, Gianluca; Mannella, Francesco; Fiore, Vincenzo G; Redgrave, Peter; Gurney, Kevin; Mirolli, Marco

    2013-05-01

    Reinforcement (trial-and-error) learning in animals is driven by a multitude of processes. Most animals have evolved several sophisticated systems of 'extrinsic motivations' (EMs) that guide them to acquire behaviours allowing them to maintain their bodies, defend against threat, and reproduce. Animals have also evolved various systems of 'intrinsic motivations' (IMs) that allow them to acquire actions in the absence of extrinsic rewards. These actions are used later to pursue such rewards when they become available. Intrinsic motivations have been studied in Psychology for many decades and their biological substrates are now being elucidated by neuroscientists. In the last two decades, investigators in computational modelling, robotics and machine learning have proposed various mechanisms that capture certain aspects of IMs. However, we still lack models of IMs that attempt to integrate all key aspects of intrinsically motivated learning and behaviour while taking into account the relevant neurobiological constraints. This paper proposes a bio-constrained system-level model that contributes a major step towards this integration. The model focusses on three processes related to IMs and on the neural mechanisms underlying them: (a) the acquisition of action-outcome associations (internal models of the agent-environment interaction) driven by phasic dopamine signals caused by sudden, unexpected changes in the environment; (b) the transient focussing of visual gaze and actions on salient portions of the environment; (c) the subsequent recall of actions to pursue extrinsic rewards based on goal-directed reactivation of the representations of their outcomes. The tests of the model, including a series of selective lesions, show how the focussing processes lead to a faster learning of action-outcome associations, and how these associations can be recruited for accomplishing goal-directed behaviours. The model, together with the background knowledge reviewed in the paper

  9. Crowdsourcing step-by-step information extraction to enhance existing how-to videos

    OpenAIRE

    Nguyen, Phu Tran; Weir, Sarah; Guo, Philip J.; Miller, Robert C.; Gajos, Krzysztof Z.; Kim, Ju Ho

    2014-01-01

    Millions of learners today use how-to videos to master new skills in a variety of domains. But browsing such videos is often tedious and inefficient because video player interfaces are not optimized for the unique step-by-step structure of such videos. This research aims to improve the learning experience of existing how-to videos with step-by-step annotations. We first performed a formative study to verify that annotations are actually useful to learners. We created ToolScape, an interac...

  10. A national action plan for workforce development in behavioral health.

    Science.gov (United States)

    Hoge, Michael A; Morris, John A; Stuart, Gail W; Huey, Leighton Y; Bergeson, Sue; Flaherty, Michael T; Morgan, Oscar; Peterson, Janice; Daniels, Allen S; Paris, Manuel; Madenwald, Kappy

    2009-07-01

    Across all sectors of the behavioral health field there has been growing concern about a workforce crisis. Difficulties encompass the recruitment and retention of staff and the delivery of accessible and effective training in both initial, preservice training and continuing education settings. Concern about the crisis led to a multiphased, cross-sector collaboration known as the Annapolis Coalition on the Behavioral Health Workforce. With support from the Substance Abuse and Mental Health Services Administration, this public-private partnership crafted An Action Plan for Behavioral Health Workforce Development. Created with input from a dozen expert panels, the action plan outlines seven core strategic goals that are relevant to all sectors of the behavioral health field: expand the role of consumers and their families in the workforce, expand the role of communities in promoting behavioral health and wellness, use systematic recruitment and retention strategies, improve training and education, foster leadership development, enhance infrastructure to support workforce development, and implement a national research and evaluation agenda. Detailed implementation tables identify the action steps for diverse groups and organizations to take in order to achieve these goals. The action plan serves as a call to action and is being used to guide workforce initiatives across the nation.

  11. Timing paradox of stepping and falls in ageing: not so quick and quick(er) on the trigger.

    Science.gov (United States)

    Rogers, Mark W; Mille, Marie-Laure

    2016-08-15

    Physiological and degenerative changes affecting human standing balance are major contributors to falls with ageing. During imbalance, stepping is a powerful protective action for preserving balance that may be voluntarily initiated in recognition of a balance threat, or be induced by an externally imposed mechanical or sensory perturbation. Paradoxically, with ageing and falls, initiation slowing of voluntary stepping is observed together with perturbation-induced steps that are triggered as fast as or faster than for younger adults. While age-associated changes in sensorimotor conduction, central neuronal processing and cognitive functions are linked to delayed voluntary stepping, alterations in the coupling of posture and locomotion may also prolong step triggering. It is less clear, however, how these factors may explain the accelerated triggering of induced stepping. We present a conceptual model that addresses this issue. For voluntary stepping, a disruption in the normal coupling between posture and locomotion may underlie step-triggering delays through suppression of the locomotion network based on an estimation of the evolving mechanical state conditions for stability. During induced stepping, accelerated step initiation may represent an event-triggering process whereby stepping is released according to the occurrence of a perturbation rather than to the specific sensorimotor information reflecting the evolving instability. In this case, errors in the parametric control of induced stepping and its effectiveness in stabilizing balance would be likely to occur. We further suggest that there is a residual adaptive capacity with ageing that could be exploited to improve paradoxical triggering and other changes in protective stepping to impact fall risk. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

  12. Exemplar-based human action pose correction.

    Science.gov (United States)

    Shen, Wei; Deng, Ke; Bai, Xiang; Leyvand, Tommer; Guo, Baining; Tu, Zhuowen

    2014-07-01

    The launch of Xbox Kinect has built a very successful computer vision product and made a big impact on the gaming industry. This sheds lights onto a wide variety of potential applications related to action recognition. The accurate estimation of human poses from the depth image is universally a critical step. However, existing pose estimation systems exhibit failures when facing severe occlusion. In this paper, we propose an exemplar-based method to learn to correct the initially estimated poses. We learn an inhomogeneous systematic bias by leveraging the exemplar information within a specific human action domain. Furthermore, as an extension, we learn a conditional model by incorporation of pose tags to further increase the accuracy of pose correction. In the experiments, significant improvements on both joint-based skeleton correction and tag prediction are observed over the contemporary approaches, including what is delivered by the current Kinect system. Our experiments for the facial landmark correction also illustrate that our algorithm can improve the accuracy of other detection/estimation systems.

  13. Effective action calculation in lattice QCD

    International Nuclear Information System (INIS)

    Hoek, J.

    1983-01-01

    A method (called the effective action method) devised to make analytic calculations in Quantum Chromodynamics in the region of strong coupling is presented. First, the author deals with developing the calculation of a strong coupling expansion of the generating functional for gauge systems on a lattice with arbitrary sources. An accompanying manual describes the implementation of this calculation on a computer. The next step consists of substituting the expressions for the one-link free energies for a specific gauge group in the result of the previous calculation. This process of substitution, together with the replacement of the sources by a bilinear combination of fermion fields, is described for the group SU(3). More details on the implementation of the substitution scheme on a computer can be found in the accompanying manual. From the effective action thus obtained in terms of meson fields and baryon fields the Green functions of the theory can be derived. As an illustrative application the effective potential determining the vacuum expectation value of the meson field is calculated. (Auth.)

  14. Action Learning: Avoiding Conflict or Enabling Action

    Science.gov (United States)

    Corley, Aileen; Thorne, Ann

    2006-01-01

    Action learning is based on the premise that action and learning are inextricably entwined and it is this potential, to enable action, which has contributed to the growth of action learning within education and management development programmes. However has this growth in action learning lead to an evolution or a dilution of Revan's classical…

  15. School Climate Improvement Action Guide for Noninstructional Staff. School Climate Improvement Resource Package

    Science.gov (United States)

    National Center on Safe Supportive Learning Environments, 2017

    2017-01-01

    Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines key action steps that noninstructional staff--including guidance counselors, social workers, school psychologists, office staff, bus drivers, maintenance and facility staff, and food service staff--can take to support school…

  16. From Framework to Action: The DESIRE Approach to Combat Desertification

    Science.gov (United States)

    Hessel, R.; Reed, M. S.; Geeson, N.; Ritsema, C. J.; van Lynden, G.; Karavitis, C. A.; Schwilch, G.; Jetten, V.; Burger, P.; van der Werff ten Bosch, M. J.; Verzandvoort, S.; van den Elsen, E.; Witsenburg, K.

    2014-11-01

    It has become increasingly clear that desertification can only be tackled through a multi-disciplinary approach that not only involves scientists but also stakeholders. In the DESIRE project such an approach was taken. As a first step, a conceptual framework was developed in which the factors and processes that may lead to land degradation and desertification were described. Many of these factors do not work independently, but can reinforce or weaken one another, and to illustrate these relationships sustainable management and policy feedback loops were included. This conceptual framework can be applied globally, but can also be made site-specific to take into account that each study site has a unique combination of bio-physical, socio-economic and political conditions. Once the conceptual framework was defined, a methodological framework was developed in which the methodological steps taken in the DESIRE approach were listed and their logic and sequence were explained. The last step was to develop a concrete working plan to put the project into action, involving stakeholders throughout the process. This series of steps, in full or in part, offers explicit guidance for other organizations or projects that aim to reduce land degradation and desertification.

  17. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1990-05-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1990) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. Also included are a number of enforcement actions that had been previously resolved but not published in this NUREG. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  18. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1989-06-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1989) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. Also included are a number of enforcement actions that had been previously resolved but not published in this NUREG. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  19. Comparison study on mechanical properties single step and three step artificial aging on duralium

    Science.gov (United States)

    Tsamroh, Dewi Izzatus; Puspitasari, Poppy; Andoko, Sasongko, M. Ilman N.; Yazirin, Cepi

    2017-09-01

    Duralium is kind of non-ferro alloy that used widely in industrial. That caused its properties such as mild, high ductility, and resistance from corrosion. This study aimed to know mechanical properties of duralium on single step and three step articial aging process. Mechanical properties that discussed in this study focused on toughness value, tensile strength, and microstructure of duralium. Toughness value of single step artificial aging was 0.082 joule/mm2, and toughness value of three step artificial aging was 0,0721 joule/mm2. Duralium tensile strength of single step artificial aging was 32.36 kgf/mm^2, and duralium tensile strength of three step artificial aging was 32,70 kgf/mm^2. Based on microstructure photo of duralium of single step artificial aging showed that precipitate (θ) was not spreading evenly indicated by black spot which increasing the toughness of material. While microstructure photo of duralium that treated by three step artificial aging showed that it had more precipitate (θ) spread evenly compared with duralium that treated by single step artificial aging.

  20. Step of quality assurance preparation on ISO 9001:2000 toward certification

    International Nuclear Information System (INIS)

    Agustiar

    2007-01-01

    ISO 9001:2000 is the International Standard for the quality management system that stipulate requirement and recommendation provided for design until product. The standard is also regulated the implementation and evaluation from management system point of view the objective to assure organization will meet specified requirement product. To propose ISO 9001:2000 certification, many steps of action should be carried out. There are 5 primary sections of the quality management system requirements of ISO 9001:2000. Quality Management system, Management responsibility, Resource management, Product realization and Measurement, Analysis and improvement, in which all will be begun with training until evaluation (author)

  1. Operating experience and corrective action program at Ontario Hydro Nuclear

    International Nuclear Information System (INIS)

    Collingwood, Barry; Turner, David

    1998-01-01

    This is a slide-based talk given at the COG/IAEA: 5. Technical Committee Meeting on 'Exchange of operating experience of pressurized heavy water reactors'. In the introduction there are presented the operating experience (OPEX) program of OHN, and the OPEX Program Mission, ensuring that the right information gets to the right staff at the right time. The OPEX Processes are analysed. These are: - Internal Corrective Action; - Inter-site Lesson Transfer; - External Lesson Transfer; - External Posting of OHN Events; - Internalizing Operating Experience. Steps in solving the Corrective Action Program are described: - Identify the Problem; - Notify Immediate Supervision/Manager; - Evaluate the Problem; - Correct the Problem; Monitor/Report Status. The Internal Corrective Action is then presented as a flowchart. The internalizing operating experience is presented under three aspects: - Communication; - Interface; - Training. The following items are discussed, respectively: peer meetings, department/section meetings, safety meetings, e-mail folders, newsletters and bulletin boards; work planning, pre-job briefings, supervisors' briefing cards; classroom initial and refresher (case studies), simulator, management courses. A diagram is presented showing the flow and treatment of information within OHN, centered on the weekly screening meetings. Finally, the corrective action processes are depicted in a flowchart and analysed in details

  2. Rapid decay of vacancy islands at step edges on Ag(111): step orientation dependence

    International Nuclear Information System (INIS)

    Shen, Mingmin; Thiel, P A; Jenks, Cynthia J; Evans, J W

    2010-01-01

    Previous work has established that vacancy islands or pits fill much more quickly when they are in contact with a step edge, such that the common boundary is a double step. The present work focuses on the effect of the orientation of that step, with two possibilities existing for a face centered cubic (111) surface: A- and B-type steps. We find that the following features can depend on the orientation: (1) the shapes of islands while they shrink; (2) whether the island remains attached to the step edge; and (3) the rate of filling. The first two effects can be explained by the different rates of adatom diffusion along the A- and B-steps that define the pit, enhanced by the different filling rates. The third observation-the difference in the filling rate itself-is explained within the context of the concerted exchange mechanism at the double step. This process is facile at all regular sites along B-steps, but only at kink sites along A-steps, which explains the different rates. We also observe that oxygen can greatly accelerate the decay process, although it has no apparent effect on an isolated vacancy island (i.e. an island that is not in contact with a step).

  3. Comparison of step-by-step kinematics of resisted, assisted and unloaded 20-m sprint runs.

    Science.gov (United States)

    van den Tillaar, Roland; Gamble, Paul

    2018-03-26

    This investigation examined step-by-step kinematics of sprint running acceleration. Using a randomised counterbalanced approach, 37 female team handball players (age 17.8 ± 1.6 years, body mass 69.6 ± 9.1 kg, height 1.74 ± 0.06 m) performed resisted, assisted and unloaded 20-m sprints within a single session. 20-m sprint times and step velocity, as well as step length, step frequency, contact and flight times of each step were evaluated for each condition with a laser gun and an infrared mat. Almost all measured parameters were altered for each step under the resisted and assisted sprint conditions (η 2  ≥ 0.28). The exception was step frequency, which did not differ between assisted and normal sprints. Contact time, flight time and step frequency at almost each step were different between 'fast' vs. 'slow' sub-groups (η 2  ≥ 0.22). Nevertheless overall both groups responded similarly to the respective sprint conditions. No significant differences in step length were observed between groups for the respective condition. It is possible that continued exposure to assisted sprinting might allow the female team-sports players studied to adapt their coordination to the 'over-speed' condition and increase step frequency. It is notable that step-by-step kinematics in these sprints were easy to obtain using relatively inexpensive equipment with possibilities of direct feedback.

  4. The operators' non-compliance behavior to conduct emergency operating procedures--comparing with the work experience and the complexity of procedural steps

    International Nuclear Information System (INIS)

    Park, Jinkyun; Jung, Wondea

    2003-01-01

    Many kinds of procedures have been used to reduce the operators' workload throughout various industries, such as in the aviation, the chemical and the nuclear industry. It is remarkable that, however, significant portion of accidents or incidents was caused by procedure related human error due to non-compliance of procedures. In this study, to investigate the operators' non-compliance behavior, emergency-training records were collected using a full scope simulator. And three types of the operators' behavior (such as strict adherence, skipping redundant actions and modifying action sequences) observed from collected emergency training records were compared with both their work experience and the complexity of procedural steps. As the results, three remarkable relationships are obtained. They are: (1) the operators who have an intermediate work experience seem to frequently adopt non-compliance behavior to conduct the procedural steps, (2) the operators seem to frequently adopt non-compliance behavior to conduct the procedural steps that have an intermediate procedural complexity, and (3) the senior reactor operators seem to accommodate their non-compliance behavior based on the complexity of procedural steps. Therefore, it is expected that these relationships can be used as meaningful clues not only to scrutinize the reason for non-compliance behavior but also to suggest appropriate remedies for the reduction of non-compliance behavior that can result in procedure related human error

  5. When a Step Is Not a Step! Specificity Analysis of Five Physical Activity Monitors.

    Science.gov (United States)

    O'Connell, Sandra; ÓLaighin, Gearóid; Quinlan, Leo R

    2017-01-01

    Physical activity is an essential aspect of a healthy lifestyle for both physical and mental health states. As step count is one of the most utilized measures for quantifying physical activity it is important that activity-monitoring devices be both sensitive and specific in recording actual steps taken and disregard non-stepping body movements. The objective of this study was to assess the specificity of five activity monitors during a variety of prescribed non-stepping activities. Participants wore five activity monitors simultaneously for a variety of prescribed activities including deskwork, taking an elevator, taking a bus journey, automobile driving, washing and drying dishes; functional reaching task; indoor cycling; outdoor cycling; and indoor rowing. Each task was carried out for either a specific duration of time or over a specific distance. Activity monitors tested were the ActivPAL micro™, NL-2000™ pedometer, Withings Smart Activity Monitor Tracker (Pulse O2)™, Fitbit One™ and Jawbone UP™. Participants were video-recorded while carrying out the prescribed activities and the false positive step count registered on each activity monitor was obtained and compared to the video. All activity monitors registered a significant number of false positive steps per minute during one or more of the prescribed activities. The Withings™ activity performed best, registering a significant number of false positive steps per minute during the outdoor cycling activity only (P = 0.025). The Jawbone™ registered a significant number of false positive steps during the functional reaching task and while washing and drying dishes, which involved arm and hand movement (P positive steps during the cycling exercises (P positive steps were registered on the activity monitors during the non-stepping activities, the authors conclude that non-stepping physical activities can result in the false detection of steps. This can negatively affect the quantification of physical

  6. Swedish Acceptance and Action Questionnaire (SAAQ): a psychometric evaluation.

    Science.gov (United States)

    Lundgren, Tobias; Parling, Thomas

    2017-06-01

    Psychological inflexibility and experiential avoidance are equivalent (with somewhat different connotations) concepts and refer to an unwillingness to remain in contact with particular private events. This concept is most often measured by the Acceptance and Action Questionnaire (AAQ-II) and is strongly related to psychopathology and behavioral effectiveness. In this study, the preliminary psychometric properties of the Swedish version of the AAQ-II (Swedish Acceptance and Action Questionnaire-SAAQ) are presented. The study is done in two steps. In the first step, the 10-item version of the AAQ-II is investigated through principal component analysis (n = 147). Secondly, due to problems with the component structure, the instrument is reduced to a six-item version and its validity and internal consistency are investigated (n = 154). The six-item version shows good concurrent and convergent validity as well as satisfying internal consistency (α = .85). Furthermore, the Swedish six-item version of the AAQ-II showed one strong component. Test-retest reliability was satisfactory (r = .80; n = 228). In future research, predictive and external validity would be important to investigate in order to further ensure that the SAAQ is a useful measure for clinical research. In conclusion, the SAAQ has satisfactory psychometric properties, but more data need to be gathered to further explore the possibilities for the instruments in Swedish contexts.

  7. On the Convexity of Step out - Step in Sequencing Games

    NARCIS (Netherlands)

    Musegaas, Marieke; Borm, Peter; Quant, Marieke

    2016-01-01

    The main result of this paper is the convexity of Step out - Step in (SoSi) sequencing games, a class of relaxed sequencing games first analyzed by Musegaas, Borm, and Quant (2015). The proof makes use of a polynomial time algorithm determining the value and an optimal processing order for an

  8. Microsoft® Office Access™ 2007 Step by Step

    CERN Document Server

    Lambert, Steve; Lambert, Joan

    2009-01-01

    Experience learning made easy-and quickly teach yourself how to build database solutions with Access 2007. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them! Build databases from scratch or from templatesExchange data with other databases and Office documentsCreate forms to simplify data entryUse filters and queries to find and analyze informationDesign rich reports that help make your data meaningfulHelp prevent data corruption and unauthorized access Your all-in-one learning experience includes: Files for building skills and practic

  9. Role of step stiffness and kinks in the relaxation of vicinal (001) with zigzag [110] steps

    Science.gov (United States)

    Mahjoub, B.; Hamouda, Ajmi BH.; Einstein, TL.

    2017-08-01

    We present a kinetic Monte Carlo study of the relaxation dynamics and steady state configurations of 〈110〉 steps on a vicinal (001) simple cubic surface. This system is interesting because 〈110〉 (fully kinked) steps have different elementary excitation energetics and favor step diffusion more than 〈100〉 (nominally straight) steps. In this study we show how this leads to different relaxation dynamics as well as to different steady state configurations, including that 2-bond breaking processes are rate determining for 〈110〉 steps in contrast to 3-bond breaking processes for 〈100〉-steps found in previous work [Surface Sci. 602, 3569 (2008)]. The analysis of the terrace-width distribution (TWD) shows a significant role of kink-generation-annihilation processes during the relaxation of steps: the kinetic of relaxation, toward the steady state, is much faster in the case of 〈110〉-zigzag steps, with a higher standard deviation of the TWD, in agreement with a decrease of step stiffness due to orientation. We conclude that smaller step stiffness leads inexorably to faster step dynamics towards the steady state. The step-edge anisotropy slows the relaxation of steps and increases the strength of step-step effective interactions.

  10. Controlling Attention through Action: Observing Actions Primes Action-Related Stimulus Dimensions

    Science.gov (United States)

    Fagioli, Sabrina; Ferlazzo, Fabio; Hommel, Bernhard

    2007-01-01

    Previous findings suggest that planning an action "backward-primes" perceptual dimension related to this action: planning a grasp facilitates the processing of visual size information, while planning a reach facilitates the processing of location information. Here we show that dimensional priming of perception through action occurs even in the…

  11. The bounded proof property via step algebras and step frames

    NARCIS (Netherlands)

    Bezhanishvili, N.; Ghilardi, Silvio

    2013-01-01

    We develop a semantic criterion for a specific rule-based calculus Ax axiomatizing a given logic L to have the so-called bounded proof property. This property is a kind of an analytic subformula property limiting the proof search space. Our main tools are one-step frames and one-step algebras. These

  12. Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism*

    Science.gov (United States)

    Dyachok, Julia; Earnest, Svetlana; Iturraran, Erica N.; Cobb, Melanie H.

    2016-01-01

    The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cell growth with its nutritional, hormonal, energy, and stress status. Amino acids are critical regulators of mTORC1 that permit other inputs to mTORC1 activity. However, the roles of individual amino acids and their interactions in mTORC1 activation are not well understood. Here we demonstrate that activation of mTORC1 by amino acids includes two discrete and separable steps: priming and activation. Sensitizing mTORC1 activation by priming amino acids is a prerequisite for subsequent stimulation of mTORC1 by activating amino acids. Priming is achieved by a group of amino acids that includes l-asparagine, l-glutamine, l-threonine, l-arginine, l-glycine, l-proline, l-serine, l-alanine, and l-glutamic acid. The group of activating amino acids is dominated by l-leucine but also includes l-methionine, l-isoleucine, and l-valine. l-Cysteine predominantly inhibits priming but not the activating step. Priming and activating steps differ in their requirements for amino acid concentration and duration of treatment. Priming and activating amino acids use mechanisms that are distinct both from each other and from growth factor signaling. Neither step requires intact tuberous sclerosis complex of proteins to activate mTORC1. Concerted action of priming and activating amino acids is required to localize mTORC1 to lysosomes and achieve its activation. PMID:27587390

  13. When a Step Is Not a Step! Specificity Analysis of Five Physical Activity Monitors.

    Directory of Open Access Journals (Sweden)

    Sandra O'Connell

    Full Text Available Physical activity is an essential aspect of a healthy lifestyle for both physical and mental health states. As step count is one of the most utilized measures for quantifying physical activity it is important that activity-monitoring devices be both sensitive and specific in recording actual steps taken and disregard non-stepping body movements. The objective of this study was to assess the specificity of five activity monitors during a variety of prescribed non-stepping activities.Participants wore five activity monitors simultaneously for a variety of prescribed activities including deskwork, taking an elevator, taking a bus journey, automobile driving, washing and drying dishes; functional reaching task; indoor cycling; outdoor cycling; and indoor rowing. Each task was carried out for either a specific duration of time or over a specific distance. Activity monitors tested were the ActivPAL micro™, NL-2000™ pedometer, Withings Smart Activity Monitor Tracker (Pulse O2™, Fitbit One™ and Jawbone UP™. Participants were video-recorded while carrying out the prescribed activities and the false positive step count registered on each activity monitor was obtained and compared to the video.All activity monitors registered a significant number of false positive steps per minute during one or more of the prescribed activities. The Withings™ activity performed best, registering a significant number of false positive steps per minute during the outdoor cycling activity only (P = 0.025. The Jawbone™ registered a significant number of false positive steps during the functional reaching task and while washing and drying dishes, which involved arm and hand movement (P < 0.01 for both. The ActivPAL™ registered a significant number of false positive steps during the cycling exercises (P < 0.001 for both.As a number of false positive steps were registered on the activity monitors during the non-stepping activities, the authors conclude that non-stepping

  14. From raw material to dish: pasta quality step by step.

    Science.gov (United States)

    Sicignano, Angelo; Di Monaco, Rossella; Masi, Paolo; Cavella, Silvana

    2015-10-01

    Pasta is a traditional Italian cereal-based food that is popular worldwide because of its convenience, versatility, sensory and nutritional value. The aim of this review is to present a step-by-step guide to facilitate the understanding of the most important events that can affect pasta characteristics, directing the reader to the appropriate production steps. Owing to its unique flavor, color, composition and rheological properties, durum wheat semolina is the best raw material for pasta production. Although pasta is traditionally made from only two ingredients, sensory quality and chemical/physical characteristics of the final product may vary greatly. Starting from the same ingredients, there are a lot of different events in each step of pasta production that can result in the development of varieties of pasta with different characteristics. In particular, numerous studies have demonstrated the importance of temperature and humidity conditions of the pasta drying operation as well as the significance of the choice of raw material and operating conditions on pasta quality. © 2015 Society of Chemical Industry.

  15. Step by step parallel programming method for molecular dynamics code

    International Nuclear Information System (INIS)

    Orii, Shigeo; Ohta, Toshio

    1996-07-01

    Parallel programming for a numerical simulation program of molecular dynamics is carried out with a step-by-step programming technique using the two phase method. As a result, within the range of a certain computing parameters, it is found to obtain parallel performance by using the level of parallel programming which decomposes the calculation according to indices of do-loops into each processor on the vector parallel computer VPP500 and the scalar parallel computer Paragon. It is also found that VPP500 shows parallel performance in wider range computing parameters. The reason is that the time cost of the program parts, which can not be reduced by the do-loop level of the parallel programming, can be reduced to the negligible level by the vectorization. After that, the time consuming parts of the program are concentrated on less parts that can be accelerated by the do-loop level of the parallel programming. This report shows the step-by-step parallel programming method and the parallel performance of the molecular dynamics code on VPP500 and Paragon. (author)

  16. Corrective Action Investigation Plan for Corrective Action Unit 542: Disposal Holes, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    Laura Pastor

    2006-01-01

    locate previously unidentified features at CASs 03-20-07, 03-20-09, 03-20-10, 03-20-11, and 06-20-03. (4) Perform field screening. (5) Collect and submit environmental samples for laboratory analysis to determine whether contaminants of concern (COCs) are present. (6) Collect quality control samples for laboratory analyses to evaluate the performance of measurement systems and controls based on the requirements of the data quality indicators. (7) If COCs are present at the surface/near surface (< 15 feet below ground surface), collect additional step-out samples to define the extent of the contamination. (8) If COCs are present in the subsurface (i.e., base of disposal hole), collect additional samples to define the vertical extent of contamination. A conservative use restriction will be used to encompass the lateral extent of subsurface contamination. (9) Stake or flag sample locations in the field, and record coordinates through global positioning systems surveying. (10) Collect samples of investigation-derived waste, as needed, for waste management and minimization purposes. This Corrective Action Investigation Plan has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' that was agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. Under the ''Federal Facility Agreement and Consent Order'', this Corrective Action Investigation Plan will be submitted to the Nevada Division of Environmental Protection for approval. Field work will be conducted following approval of the plan

  17. Developing Effective Corrective Action Plan in Krsko NPP

    International Nuclear Information System (INIS)

    Bach, Bruno; Cizmek, Rudi; Bozin, Bojan

    2014-01-01

    OE program regarding to developing effective and efficient corrective action plan based both on internal and industry events. It will describe the key steps of developing, implementing and assessing the effectiveness of corrective actions that address issues identified in the OE program and includes the following aspects: a. Developing effective corrective actions, b. Prioritizing corrective actions, c. Implementing corrective actions successfully, d. Assessing the effectiveness of the corrective actions. (authors)

  18. School Climate Improvement Action Guide for Working with Families. School Climate Improvement Resource Package

    Science.gov (United States)

    National Center on Safe Supportive Learning Environments, 2017

    2017-01-01

    Improving school climate takes time and commitment from a variety of people in a variety of roles. This document outlines how family members--including guardians of students--can support school climate improvements. Key action steps are provided for the following strategies: (1) Participate in planning for school climate improvements; (2) Engage…

  19. Quality maternity care for every woman, everywhere: a call to action.

    Science.gov (United States)

    Koblinsky, Marjorie; Moyer, Cheryl A; Calvert, Clara; Campbell, James; Campbell, Oona M R; Feigl, Andrea B; Graham, Wendy J; Hatt, Laurel; Hodgins, Steve; Matthews, Zoe; McDougall, Lori; Moran, Allisyn C; Nandakumar, Allyala K; Langer, Ana

    2016-11-05

    To improve maternal health requires action to ensure quality maternal health care for all women and girls, and to guarantee access to care for those outside the system. In this paper, we highlight some of the most pressing issues in maternal health and ask: what steps can be taken in the next 5 years to catalyse action toward achieving the Sustainable Development Goal target of less than 70 maternal deaths per 100 000 livebirths by 2030, with no single country exceeding 140? What steps can be taken to ensure that high-quality maternal health care is prioritised for every woman and girl everywhere? We call on all stakeholders to work together in securing a healthy, prosperous future for all women. National and local governments must be supported by development partners, civil society, and the private sector in leading efforts to improve maternal-perinatal health. This effort means dedicating needed policies and resources, and sustaining implementation to address the many factors influencing maternal health-care provision and use. Five priority actions emerge for all partners: prioritise quality maternal health services that respond to the local specificities of need, and meet emerging challenges; promote equity through universal coverage of quality maternal health services, including for the most vulnerable women; increase the resilience and strength of health systems by optimising the health workforce, and improve facility capability; guarantee sustainable finances for maternal-perinatal health; and accelerate progress through evidence, advocacy, and accountability. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Testing a stepped care model for binge-eating disorder: a two-step randomized controlled trial.

    Science.gov (United States)

    Tasca, Giorgio A; Koszycki, Diana; Brugnera, Agostino; Chyurlia, Livia; Hammond, Nicole; Francis, Kylie; Ritchie, Kerri; Ivanova, Iryna; Proulx, Genevieve; Wilson, Brian; Beaulac, Julie; Bissada, Hany; Beasley, Erin; Mcquaid, Nancy; Grenon, Renee; Fortin-Langelier, Benjamin; Compare, Angelo; Balfour, Louise

    2018-05-24

    A stepped care approach involves patients first receiving low-intensity treatment followed by higher intensity treatment. This two-step randomized controlled trial investigated the efficacy of a sequential stepped care approach for the psychological treatment of binge-eating disorder (BED). In the first step, all participants with BED (n = 135) received unguided self-help (USH) based on a cognitive-behavioral therapy model. In the second step, participants who remained in the trial were randomized either to 16 weeks of group psychodynamic-interpersonal psychotherapy (GPIP) (n = 39) or to a no-treatment control condition (n = 46). Outcomes were assessed for USH in step 1, and then for step 2 up to 6-months post-treatment using multilevel regression slope discontinuity models. In the first step, USH resulted in large and statistically significant reductions in the frequency of binge eating. Statistically significant moderate to large reductions in eating disorder cognitions were also noted. In the second step, there was no difference in change in frequency of binge eating between GPIP and the control condition. Compared with controls, GPIP resulted in significant and large improvement in attachment avoidance and interpersonal problems. The findings indicated that a second step of a stepped care approach did not significantly reduce binge-eating symptoms beyond the effects of USH alone. The study provided some evidence for the second step potentially to reduce factors known to maintain binge eating in the long run, such as attachment avoidance and interpersonal problems.

  1. Mass Action Stoichiometric. Simulation for Cell Factory Design

    DEFF Research Database (Denmark)

    Matos, Marta R. A.

    -state, giving information only about the reactions’ fluxes, while the latter take into account enzyme dynamics which makes it possible to model substrate-level enzyme regulation and get information about metabolite concentrations and reaction fluxes over time, although at the cost of introducing more parameters....... Kinetic models have been plagued by the lack of kinetic data. The focus of this thesis are kinetic models of cell metabolism. In this work we start by developing a software package to create a model ensemble for individual enzymes in metabolism, where we decompose each reaction into elementary steps......, using mass action kinetics to model each step. The resulting rate constants are then fitted to kinetic data (kcat, Km, Ki, etc.). We then use the package as the basis to build a system-level kinetic model. To do so, we take two different approaches, and in both we drop the assumption that χfree ≈ χtot...

  2. Step-by-step phacoemulsification training program for ophthalmology residents

    Directory of Open Access Journals (Sweden)

    Wang Yulan

    2013-01-01

    Full Text Available Aims: The aim was to analyze the learning curve of phacoemulsification (phaco performed by residents without experience in performing extra-capsular cataract extraction (ECCE in a step-by-step training program (SBSTP. Materials and Methods: Consecutive surgical records of phaco performed from March 2009 to Sept 2011 by four residents without previous ECCE experience were retrospectively reviewed. The completion rate of the first 30 procedures by each resident was calculated. The main intraoperative phaco parameter records for the first 30 surgeries by each resident were compared with those for their last 30 surgeries. Intraoperative complications in the residents′ procedures were also recorded and analyzed. Results: A total of 1013 surgeries were performed by residents. The completion rate for the first 30 phaco procedures was 79.2 μ 5.8%. The main reasons for halting the procedure were as follows: Anterior capsule tear, inability to crack the nucleus, and posterior capsular rupture during phaco or cortex removal. Cumulative dissipated energy of phaco power used during the surgeries was significantly less in the last 30 cases compared with the first 30 cases (30.10 μ 17.58 vs. 55.41 μ 37.59, P = 0.021. Posterior capsular rupture rate was 2.5 μ 1.2% in total (10.8 μ 4.2% in the first 30 cases and 1.7 μ 1.9% in the last 30 cases, P = 0.008; a statistically significant difference. Conclusion:The step-by-step training program might be a necessary process for a resident to transit from dependence to a self-supported operator. It is also an essential middle step between wet lab training to performing the entire phaco procedure on the patient both effectively and safely.

  3. Comparing the efficacy of metronome beeps and stepping stones to adjust gait: steps to follow!

    Science.gov (United States)

    Bank, Paulina J M; Roerdink, Melvyn; Peper, C E

    2011-03-01

    Acoustic metronomes and visual targets have been used in rehabilitation practice to improve pathological gait. In addition, they may be instrumental in evaluating and training instantaneous gait adjustments. The aim of this study was to compare the efficacy of two cue types in inducing gait adjustments, viz. acoustic temporal cues in the form of metronome beeps and visual spatial cues in the form of projected stepping stones. Twenty healthy elderly (aged 63.2 ± 3.6 years) were recruited to walk on an instrumented treadmill at preferred speed and cadence, paced by either metronome beeps or projected stepping stones. Gait adaptations were induced using two manipulations: by perturbing the sequence of cues and by imposing switches from one cueing type to the other. Responses to these manipulations were quantified in terms of step-length and step-time adjustments, the percentage correction achieved over subsequent steps, and the number of steps required to restore the relation between gait and the beeps or stepping stones. The results showed that perturbations in a sequence of stepping stones were overcome faster than those in a sequence of metronome beeps. In switching trials, switching from metronome beeps to stepping stones was achieved faster than vice versa, indicating that gait was influenced more strongly by the stepping stones than the metronome beeps. Together these results revealed that, in healthy elderly, the stepping stones induced gait adjustments more effectively than did the metronome beeps. Potential implications for the use of metronome beeps and stepping stones in gait rehabilitation practice are discussed.

  4. Town of Canmore Energy Management Action Plan (EMAP)

    International Nuclear Information System (INIS)

    2005-03-01

    In 1999, the Town of Canmore, Alberta joined the Federation of Canadian Municipalities' Partners for Climate Protection (PCP) Program and committed to reducing greenhouse gas (GHG) emissions from municipal operations by 20 per cent and community-wide emissions by 6 per cent of 2000 levels by 2012. To date, the City has completed a baseline analysis for municipal operations and the community. It has also initiated an Energy Management Action Plan (EMAP) to identify opportunities in sustainable development through energy, GHG and air quality management. The broad community objectives include housing and transportation management, job creation and local economic development. The city has adopted The Natural Step (TNS) framework which defines sustainability and the guiding principles for decision-making. The objectives of EMAP are to define and evaluate options for a practical strategy and action plan to meet the city's GHG reduction targets; raise local awareness of the issues and opportunities of energy planning and GHG reductions and develop a local action plan outlining action items to reduce energy use and GHG emissions from municipal operations throughout the community. This report explained the methodology and framework for EMAP management and presented a community profile for the Town of Canmore. It also included an energy and emissions inventory and forecast with reference to corporate energy and emissions baseline; community energy and emissions baseline; corporate energy and emissions forecast; community energy and emissions forecast and corporate and community GHG targets. refs., tabs., figs

  5. Influence of step complexity and presentation style on step performance of computerized emergency operating procedures

    Energy Technology Data Exchange (ETDEWEB)

    Xu Song [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China); Li Zhizhong [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China)], E-mail: zzli@tsinghua.edu.cn; Song Fei; Luo Wei; Zhao Qianyi; Salvendy, Gavriel [Department of Industrial Engineering, Tsinghua University, Beijing 100084 (China)

    2009-02-15

    With the development of information technology, computerized emergency operating procedures (EOPs) are taking the place of paper-based ones. However, ergonomics issues of computerized EOPs have not been studied adequately since the industrial practice is quite limited yet. This study examined the influence of step complexity and presentation style of EOPs on step performance. A simulated computerized EOP system was developed in two presentation styles: Style A: one- and two-dimensional flowcharts combination; Style B: two-dimensional flowchart and success logic tree combination. Step complexity was quantified by a complexity measure model based on an entropy concept. Forty subjects participated in the experiment of EOP execution using the simulated system. The results of data analysis on the experiment data indicate that step complexity and presentation style could significantly influence step performance (both step error rate and operation time). Regression models were also developed. The regression analysis results imply that operation time of a step could be well predicted by step complexity while step error rate could only partly predicted by it. The result of a questionnaire investigation implies that step error rate was influenced not only by the operation task itself but also by other human factors. These findings may be useful for the design and assessment of computerized EOPs.

  6. Uranium Mill Tailings Remedial Action 1993 Roadmap

    International Nuclear Information System (INIS)

    1993-01-01

    The 1993 Roadmap for the Uranium Mill Tailings Remedial Action (UMTRA) Project office is a tool to assess and resolve issues. The US Department of Energy (DOE) UMTRA Project Office uses the nine-step roadmapping process as a basis for Surface and Groundwater Project planning. This is the second year the Roadmap document has been used to identify key issues and assumptions, develop logic diagrams, and outline milestones. This document is a key element of the DOE planning process. A multi-interest group used the nine-step process to focus on issues, root cause analysis and resolutions. This core group updated and incorporated comments on the basic assumptions, then used these assumptions to identify issues. The list of assumptions was categorized into the following areas: institutional, regulatory compliance, project management, human resource requirements, and other site-specific assumptions. The group identified 10 issues in the analysis phase. All of the issues are ranked according to importance. The number one issue from the 1992 Roadmap, ''Lack of sufficient human resources,'' remained the number one issue in 1993. The issues and their ranking are as follows: Lack of sufficient human resources; increasing regulatory requirements; unresolved groundwater issues; extension of UMTRCA through September 30, 1998; lack of post-UMTRA and post-cell closure policies; unpredictable amounts and timing of Federal funding; lack of regulatory compliance agreements; problem with states providing their share of remedial action costs; different interests and priorities among participants; and technology development/transfer. The issues are outlined and analyzed in detail in Section 8.0, with a schedule for resolution of these issues in Section 9.0

  7. Diabetes PSA (:30) Step By Step

    Centers for Disease Control (CDC) Podcasts

    2009-10-24

    First steps to preventing diabetes. For Hispanic and Latino American audiences.  Created: 10/24/2009 by National Diabetes Education Program (NDEP), a joint program of the Centers for Disease Control and Prevention and the National Institutes of Health.   Date Released: 10/24/2009.

  8. Diabetes PSA (:60) Step By Step

    Centers for Disease Control (CDC) Podcasts

    2009-10-24

    First steps to preventing diabetes. For Hispanic and Latino American audiences.  Created: 10/24/2009 by National Diabetes Education Program (NDEP), a joint program of the Centers for Disease Control and Prevention and the National Institutes of Health.   Date Released: 10/24/2009.

  9. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1990-09-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April--June 1990) and includes copies of letters, notices, and orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  10. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1994-03-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October - December 1993) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  11. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1991-05-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1991) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  12. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1993-09-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April--June 1993) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  13. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1990-11-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July--September 1990) and includes copies of letters, notices, and orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  14. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1992-08-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April--June 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  15. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1991-02-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1990) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  16. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1993-06-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1993) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  17. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1990-03-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1989) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  18. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1991-07-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April-June 1991) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  19. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1992-05-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  20. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1993-12-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July--September 1993) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  1. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1993-03-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  2. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1991-11-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July--September 1991) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  3. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1992-03-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1991) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  4. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1992-11-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July - September 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  5. Enforcement actions: Significant actions resolved

    International Nuclear Information System (INIS)

    1989-12-01

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July--September 1989) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  6. Accuracy of Single-Step versus 2-Step Double-Mix Impression Technique

    DEFF Research Database (Denmark)

    Franco, Eduardo Batista; da Cunha, Leonardo Fernandes; Herrera, Francyle Simões

    2011-01-01

    Objective. To investigate the accuracy of dies obtained from single-step and 2-step double-mix impressions. Material and Methods. Impressions (n = 10) of a stainless steel die simulating a complete crown preparation were performed using a polyether (Impregum Soft Heavy and Light body) and a vinyl...

  7. THORP steps up the concrete action

    International Nuclear Information System (INIS)

    Hayward, D.

    1987-01-01

    The construction of the THORP reprocessing plant at the BNFL Sellafield site is complex and made more so by design modifications. Over 100 huge concrete cells, each enclosed by heavily reinforced 1.5m thick walls will eventually be clad in metal sheeting to make one vast long building 285m long and 50m tall. The quality assurance tolerances required are tight. Currently the building is behind schedule so the construction is now going throughout the night as well as the day. As well as the demands made by building complexities the requirements of nuclear engineering must be met. Also, this is the first building in the UK which will have to comply with the Nuclear Installations Inspectorate demands for seismic safety. An idea of the scale of the building in the UK which will have to comply with the Nuclear Installations Inspectorate demands for seismic safety. An idea of the scale of the building, the logistical problems, their solutions and the timescale of the construction are given. (UK)

  8. Humanities for the Environment—A Manifesto for Research and Action

    Directory of Open Access Journals (Sweden)

    Poul Holm

    2015-12-01

    Full Text Available Human preferences, practices and actions are the main drivers of global environmental change in the 21st century. It is crucial, therefore, to promote pro-environmental behavior. In order to accomplish this, we need to move beyond rational choice and behavioral decision theories, which do not capture the full range of commitments, assumptions, imaginaries, and belief systems that drive those preferences and actions. Humanities disciplines, such as philosophy, history, religious studies, gender studies, language and literary studies, psychology, and pedagogics do offer deep insights into human motivations, values, and choices. We believe that the expertise of such fields for transforming human preferences, practices and actions is ignored at society’s peril. We propose an agenda that focuses global humanities research on stepping up to the challenges of planetary environmental change. We have established Environmental Humanities Observatories through which to observe, explore and enact the crucial ways humanistic disciplines may help us understand and engage with global ecological problems by providing insight into human action, perceptions, and motivation. We present this Manifesto as an invitation for others to join the “Humanities for the Environment” open global consortium of humanities observatories as we continue to develop a shared research agenda.

  9. Action on Pre-eclampsia: Crisis and recovery.

    Science.gov (United States)

    Milne, Fiona

    2011-01-01

    This is a review of the antenatal guidelines developed under the auspices of the charity Action on Preeclampsia since 2001. They are evidence-based and cover the screening and diagnosis of preeclampsia. They include a risk assessment early in pregnancy, referral for specialist input, a two tier schedule of assessment based on risk, signs and symptoms, referral for step-up care and confirmation of diagnosis, including blood tests. They describe methods for improving reliability of proteinuria testing, and reducing errors in the measurement of blood pressure. Management flowcharts are provided. Copyright © 2010 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  10. Mining Together : Large-Scale Mining Meets Artisanal Mining, A Guide for Action

    OpenAIRE

    World Bank

    2009-01-01

    The present guide mining together-when large-scale mining meets artisanal mining is an important step to better understanding the conflict dynamics and underlying issues between large-scale and small-scale mining. This guide for action not only points to some of the challenges that both parties need to deal with in order to build a more constructive relationship, but most importantly it sh...

  11. Action preferences and the anticipation of action outcomes

    NARCIS (Netherlands)

    Mann, D.L.; Schaefers, T.; Canal Bruland, R.

    2014-01-01

    Skilled performers of time-constrained motor actions acquire information about the action preferences of their opponents in an effort to better anticipate the outcome of that opponent's actions. However, there is reason to doubt that knowledge of an opponent's action preferences would unequivocally

  12. Corrective Action Investigation Plan for Corrective Action Unit 166: Storage Yards and Contaminated Materials, Nevada Test Site, Nevada, Rev. No.: 0

    Energy Technology Data Exchange (ETDEWEB)

    David Strand

    2006-06-01

    contaminants of concern are present. (5) If contaminants of concern are present, collect additional step-out samples to define the extent of the contamination. (6) Collect samples of investigation-derived waste, as needed, for waste management and minimization purposes. This Corrective Action Investigation Plan has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' that was agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. Under the ''Federal Facility Agreement and Consent Order'', this Corrective Action Investigation Plan will be submitted to the Nevada Division of Environmental Protection, and field work will commence following approval.

  13. Preimages for Step-Reduced SHA-2

    DEFF Research Database (Denmark)

    Aoki, Kazumaro; Guo, Jian; Matusiewicz, Krystian

    2009-01-01

    In this paper, we present preimage attacks on up to 43-step SHA-256 (around 67% of the total 64 steps) and 46-step SHA-512 (around 57.5% of the total 80 steps), which significantly increases the number of attacked steps compared to the best previously published preimage attack working for 24 steps....... The time complexities are 2^251.9, 2^509 for finding pseudo-preimages and 2^254.9, 2^511.5 compression function operations for full preimages. The memory requirements are modest, around 2^6 words for 43-step SHA-256 and 46-step SHA-512. The pseudo-preimage attack also applies to 43-step SHA-224 and SHA-384...

  14. Pendekatan Pelatihan On-Site dan Step by Step untuk Optimalisasi Fungsi Guru dalam Pembelajaran

    OpenAIRE

    Moch. Sholeh Y.A. Ichrom

    2016-01-01

    Remoteness of programme content from teachers' real work situation and unsuitability of approach employed were suspected as main reasons contributing to the failure of many inservise teacher training programmes. A step by step, onsite teacher training (SSOTT) model was tried out in this experiment to study if the weakness of inservise programmes could be rectified. As it was tried out in relation with kindergarten mathemathics it was then called SSOTT-MTW (Step by Step Onsite Teacher Training...

  15. Pendekatan Pelatihan On-Site Dan Step by Step Untuk Optimalisasi Fungsi Guru Dalam Pembelajaran

    OpenAIRE

    Ichrom, Moch. Sholeh Y.A

    1996-01-01

    Remoteness of programme content from teachers' real work situation and unsuitability of approach employed were suspected as main reasons contributing to the failure of many inservise teacher training programmes. A step by step, onsite teacher training (SSOTT) model was tried out in this experiment to study if the weakness of inservise programmes could be rectified. As it was tried out in relation with kindergarten mathemathics it was then called SSOTT-MTW (Step by Step Onsite Teacher Training...

  16. Scientific Communication for Positive Action: Do's and Don'ts

    Science.gov (United States)

    Sanquini, A.; Wood, M. M.

    2015-12-01

    Natural hazard presentations often highlight disasters that may ensue from natural processes when mitigation or preparedness actions are not taken. Examples include images of raging fires, collapsed buildings, and flooded urban areas. Research has shown that this makes presentations more interesting and more memorable. Such images are the stock and trade of disaster reporting by the media. Unfortunately, it may also trigger avoidance and denial in the audience, resulting in preparedness reduction; the opposite effect of what may have been intended by the speaker. Recent social research has provided insight into a better approach. The theory of communicating actionable risk posits that people will take action against hazards when they know what to do, think it would work, and know someone who did it. This approach was recently applied in an intervention designed to motivate earthquake-resistant construction in Kathmandu Valley, Nepal. Social theory further suggests that a tendency towards action is strengthened by hearing a consistent message over time, and by providing the audience with an appropriate opportunity to seek out relevant information. This presentation shows how, by taking this transdisciplinary step, scientists can make small changes in their hazard communication, thereby acting as positive influencers of change. A summary of "do's" and "don'ts" is given for reference. 1. Show examples of what to do. 2. Show effectiveness of actions. 3. Give sense of knowing someone who did it. 4. Deliver consistent message, repeatedly. 5. Give opportunity for more information. DON'T: 1. Make the disaster the star. 2. Contradict other communications.

  17. Dynamical modeling of microRNA action on the protein translation process.

    Science.gov (United States)

    Zinovyev, Andrei; Morozova, Nadya; Nonne, Nora; Barillot, Emmanuel; Harel-Bellan, Annick; Gorban, Alexander N

    2010-02-24

    Protein translation is a multistep process which can be represented as a cascade of biochemical reactions (initiation, ribosome assembly, elongation, etc.), the rate of which can be regulated by small non-coding microRNAs through multiple mechanisms. It remains unclear what mechanisms of microRNA action are the most dominant: moreover, many experimental reports deliver controversial messages on what is the concrete mechanism actually observed in the experiment. Nissan and Parker have recently demonstrated that it might be impossible to distinguish alternative biological hypotheses using the steady state data on the rate of protein synthesis. For their analysis they used two simple kinetic models of protein translation. In contrary to the study by Nissan and Parker, we show that dynamical data allow discriminating some of the mechanisms of microRNA action. We demonstrate this using the same models as developed by Nissan and Parker for the sake of comparison but the methods developed (asymptotology of biochemical networks) can be used for other models. We formulate a hypothesis that the effect of microRNA action is measurable and observable only if it affects the dominant system (generalization of the limiting step notion for complex networks) of the protein translation machinery. The dominant system can vary in different experimental conditions that can partially explain the existing controversy of some of the experimental data. Our analysis of the transient protein translation dynamics shows that it gives enough information to verify or reject a hypothesis about a particular molecular mechanism of microRNA action on protein translation. For multiscale systems only that action of microRNA is distinguishable which affects the parameters of dominant system (critical parameters), or changes the dominant system itself. Dominant systems generalize and further develop the old and very popular idea of limiting step. Algorithms for identifying dominant systems in multiscale

  18. Dynamical modeling of microRNA action on the protein translation process

    Directory of Open Access Journals (Sweden)

    Barillot Emmanuel

    2010-02-01

    Full Text Available Abstract Background Protein translation is a multistep process which can be represented as a cascade of biochemical reactions (initiation, ribosome assembly, elongation, etc., the rate of which can be regulated by small non-coding microRNAs through multiple mechanisms. It remains unclear what mechanisms of microRNA action are the most dominant: moreover, many experimental reports deliver controversial messages on what is the concrete mechanism actually observed in the experiment. Nissan and Parker have recently demonstrated that it might be impossible to distinguish alternative biological hypotheses using the steady state data on the rate of protein synthesis. For their analysis they used two simple kinetic models of protein translation. Results In contrary to the study by Nissan and Parker, we show that dynamical data allow discriminating some of the mechanisms of microRNA action. We demonstrate this using the same models as developed by Nissan and Parker for the sake of comparison but the methods developed (asymptotology of biochemical networks can be used for other models. We formulate a hypothesis that the effect of microRNA action is measurable and observable only if it affects the dominant system (generalization of the limiting step notion for complex networks of the protein translation machinery. The dominant system can vary in different experimental conditions that can partially explain the existing controversy of some of the experimental data. Conclusions Our analysis of the transient protein translation dynamics shows that it gives enough information to verify or reject a hypothesis about a particular molecular mechanism of microRNA action on protein translation. For multiscale systems only that action of microRNA is distinguishable which affects the parameters of dominant system (critical parameters, or changes the dominant system itself. Dominant systems generalize and further develop the old and very popular idea of limiting step

  19. Immuno-pharmacodynamics for evaluating mechanism of action and developing immunotherapy combinations.

    Science.gov (United States)

    Parchment, Ralph E; Voth, Andrea Regier; Doroshow, James H; Berzofsky, Jay A

    2016-08-01

    Immunotherapy has become a major modality of cancer treatment, with multiple new classes of immunotherapeutics recently entering the clinic and obtaining market approval from regulatory agencies. While the promise of these therapies is great, so is the number of possible combinations not only with each other but also with small molecule therapeutics. Furthermore, the observation of unusual dose-response relationships suggests a critical dependency of drug effectiveness on the dosage regimen (dose and schedule). Clinical pharmacodynamic (PD) biomarkers will be useful endpoints for confirming drug mechanism of action, evaluating combination therapies for synergy or antagonism, and identifying optimal dosage regimens. In contrast to conventional PD in which drug action occurs entirely within a single target cell (ie, is self-contained within the malignant cell), immunotherapy involves a complex mechanism of action with sequential steps that propagate through multiple cell types, both normal and malignant. Its intercellular pharmacology begins with molecular target engagement either on an immune effector cell or a malignant cell, followed by stimulatory biochemical and biological signals in immune effector cells, and then finally ends with activation of cell death mechanisms in malignant cells lying within a certain distance from the activated effector cells (immune cell-tumor cell proximity). Evaluating such "trans-cellular pharmacology," in which different steps of drug action are distributed across multiple cell types, requires novel microscopy and image analysis tools capable of quantifying PD-biomarker responses, mapping the responses onto the cellular geography of the tumor using phenotypic biomarkers to identify specific cell types, and finally analyzing the spatial relationships between biomarkers in the context of each cell's biological role. We have termed this form of nearest neighbor image analysis of drug action "proximity PD microscopy," to indicate the

  20. Continuous versus step-by-step scanning mode of a novel 3D scanner for CyberKnife measurements

    International Nuclear Information System (INIS)

    Al Kafi, M Abdullah; Mwidu, Umar; Moftah, Belal

    2015-01-01

    The purpose of the study is to investigate the continuous versus step-by-step scanning mode of a commercial circular 3D scanner for commissioning measurements of a robotic stereotactic radiosurgery system. The 3D scanner was used for profile measurements in step-by-step and continuous modes with the intent of comparing the two scanning modes for consistency. The profile measurements of in-plane, cross-plane, 15 degree, and 105 degree were performed for both fixed cones and Iris collimators at depth of maximum dose and at 10 cm depth. For CyberKnife field size, penumbra, flatness and symmetry analysis, it was observed that the measurements with continuous mode, which can be up to 6 times faster than step-by-step mode, are comparable and produce scans nearly identical to step-by-step mode. When compared with centered step-by-step mode data, a fully processed continuous mode data gives rise to maximum of 0.50% and 0.60% symmetry and flatness difference respectfully for all the fixed cones and Iris collimators studied. - Highlights: • D scanner for CyberKnife beam data measurements. • Beam data analysis for continuous and step-by-step scan modes. • Faster continuous scanning data are comparable to step-by-step mode scan data.

  1. Eco-efficiency guiding micro-level actions towards sustainability. Ten basic steps for analysis

    International Nuclear Information System (INIS)

    Huppes, Gjalt; Ishikawa, Masanobu

    2009-01-01

    This paper looks at the compatibility between technological improvements at the micro-level and sustainability at the macro-level. The two main approaches to prevent environmental degradation are technological improvement and economic degrowth. How do we establish the sustainability of technological options? LCA-type analysis of the technology system, combined with economic cost analysis, offers a first integrated eco-efficiency score. However, such a technology analysis focuses on micro-level technology relations only, is usually too optimistic and ignores other constraints implied in a choice. Fitting more comprehensive knowledge into the sustainability evaluation of options requires a unifying systematic framework, which is worked out in the present paper as a ten-step procedure. The integrative framework for empirical analysis is ultimately a comparative-static systems analysis at macro-level, not in a deterministic dynamic mode, which is impossible, but as a knowledge-fed scenario analysis. The analysis shows the change in society's overall eco-efficiency, combining total value creation with total environmental impacts. Possible domains of application include not only technology choices like those in eco-innovation, including changed consumption styles and volumes, but also changes in policies regarding technologies and markets, whether direct policy shifts or indirect changes through institutional adaptations. Ultimately, such a framework also allows culturally framed questions about the type of society we would like to live in, to be analysed in terms of their economic and environmental consequences. (author)

  2. Microsoft® Office Visio® 2007 Step by Step

    CERN Document Server

    Lemke, Judy

    2009-01-01

    Experience learning made easy-and quickly teach yourself how to create professional-looking business and technical diagrams with Visio 2007. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them! Build organization charts, floor plans, and other diagramsAdd color, text, and other effectsConnect shapes and create effective flowchartsVisualize and analyze data with new PivotDiagramsInsert and modify diagrams in other Microsoft Office documentsCreate your own shapes and templates and build custom diagrams Your all-in-one learning experience in

  3. Microsoft® Office Excel® 2007 Step by Step

    CERN Document Server

    Frye, Curtis

    2009-01-01

    Experience learning made easy-and quickly teach yourself how to organize, analyze, and present data with Excel 2007. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them! Create formulas, calculate values, and analyze dataPresent information visually with graphics, charts, and diagramsBuild PivotTable dynamic views-even easier with new data tablesReuse information from databases and other documentsShare spreadsheets for review and manage changesCreate macros to automate repetitive tasks and simplify your work Your all-in-one learning expe

  4. Corrective Action Investigation Plan for Corrective Action Unit 410: Waste Disposal Trenches, Tonopah Test Range, Nevada, Revision No.:0

    International Nuclear Information System (INIS)

    2002-01-01

    , beryllium, total petroleum hydrocarbons; and total Resource Conservation and Recovery Act metals. Field activities will consist of geophysical and radiological surveys, and collecting soil samples at biased locations by appropriate methods. A two-step data quality objective strategy will be followed: (1) define the nature of contamination at each CAS location by identifying any contamination above preliminary action levels (PALs); and, (2) determine the extent of contamination identified above PALs. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document

  5. DAPs: Deep Action Proposals for Action Understanding

    KAUST Repository

    Escorcia, Victor

    2016-09-17

    Object proposals have contributed significantly to recent advances in object understanding in images. Inspired by the success of this approach, we introduce Deep Action Proposals (DAPs), an effective and efficient algorithm for generating temporal action proposals from long videos. We show how to take advantage of the vast capacity of deep learning models and memory cells to retrieve from untrimmed videos temporal segments, which are likely to contain actions. A comprehensive evaluation indicates that our approach outperforms previous work on a large scale action benchmark, runs at 134 FPS making it practical for large-scale scenarios, and exhibits an appealing ability to generalize, i.e. to retrieve good quality temporal proposals of actions unseen in training.

  6. Step 3: Manage Your Diabetes

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Type 2 Diabetes Step 3: Manage Your Diabetes Past Issues / Fall 2014 ... 2 Diabetes" Articles Diabetes Is Serious But Manageable / Step 1: Learn About Diabetes / Step 2: Know Your ...

  7. Givental action and trivialisation of circle action

    NARCIS (Netherlands)

    Dotsenko, V.; Shadrin, S.; Vallette, B.

    2015-01-01

    In this paper, we show that the Givental group action on genus zero cohomological field theories, also known as formal Frobenius manifolds or hypercommutative algebras, naturally arises in the deformation theory of Batalin-Vilkovisky algebras. We prove that the Givental action is equal to an action

  8. Effect of exercise on insulin action in human skeletal muscle

    DEFF Research Database (Denmark)

    Richter, Erik; Mikines, K J; Galbo, Henrik

    1989-01-01

    The effect of 1 h of dynamic one-legged exercise on insulin action in human muscle was studied in 6 healthy young men. Four hours after one-legged knee extensions, a three-step sequential euglycemic hyperinsulinemic clamp combined with arterial and bilateral femoral vein catheterization...... was performed. Increased insulin action on glucose uptake was found in the exercised compared with the rested thigh at mean plasma insulin concentrations of 23, 40, and 410 microU/ml. Furthermore, prior contractions directed glucose uptake toward glycogen synthesis and increased insulin effects on thigh O2...... consumption and at some insulin concentrations on potassium exchange. In contrast, no change in insulin effects on limb exchange of free fatty acids, glycerol, alanine or tyrosine were found after exercise. Glycogen concentration in rested vastus lateralis muscle did not increase measurably during the clamp...

  9. Effects of Stroke on Ipsilesional End-Effector Kinematics in a Multi-Step Activity of Daily Living

    OpenAIRE

    Gulde, Philipp; Hughes, Charmayne Mary Lee; Hermsdörfer, Joachim

    2017-01-01

    Background: Stroke frequently impairs activities of daily living (ADL) and deteriorates the function of the contra- as well as the ipsilesional limbs. In order to analyze alterations of higher motor control unaffected by paresis or sensory loss, the kinematics of ipsilesional upper limb movements in patients with stroke has previously been analyzed during prehensile movements and simple tool use actions. By contrast, motion recording of multi-step ADL is rare and patient-control comparisons f...

  10. Educational actions of energy control. Good practices of european towns; Les actions educatives de maitrise de l'energie. Bonnes pratiques de villes europeennes

    Energy Technology Data Exchange (ETDEWEB)

    Maurer, Ch

    2001-07-01

    In the framework of an energy policy against the greenhouse effect, the young people awareness to the energy conservation and the environment protection, is essential because they will be the citizens of tomorrow and in a first step, they can have influence on their parents attitude. This study presents and analyzes ten experiences of european towns concerning: the utilization or the creation of educational tools as CD-Rom, Internet, documents; operations associating teachers and students at energy control actions in their school; operations associating external interveners of the school. (A.L.B.)

  11. 2-Step IMAT and 2-Step IMRT in three dimensions

    International Nuclear Information System (INIS)

    Bratengeier, Klaus

    2005-01-01

    In two dimensions, 2-Step Intensity Modulated Arc Therapy (2-Step IMAT) and 2-Step Intensity Modulated Radiation Therapy (IMRT) were shown to be powerful methods for the optimization of plans with organs at risk (OAR) (partially) surrounded by a target volume (PTV). In three dimensions, some additional boundary conditions have to be considered to establish 2-Step IMAT as an optimization method. A further aim was to create rules for ad hoc adaptations of an IMRT plan to a daily changing PTV-OAR constellation. As a test model, a cylindrically symmetric PTV-OAR combination was used. The centrally placed OAR can adapt arbitrary diameters with different gap widths toward the PTV. Along the rotation axis the OAR diameter can vary, the OAR can even vanish at some axis positions, leaving a circular PTV. The width and weight of the second segment were the free parameters to optimize. The objective function f to minimize was the root of the integral of the squared difference of the dose in the target volume and a reference dose. For the problem, two local minima exist. Therefore, as a secondary criteria, the magnitude of hot and cold spots were taken into account. As a result, the solution with a larger segment width was recommended. From plane to plane for varying radii of PTV and OAR and for different gaps between them, different sets of weights and widths were optimal. Because only one weight for one segment shall be used for all planes (respectively leaf pairs), a strategy for complex three-dimensional (3-D) cases was established to choose a global weight. In a second step, a suitable segment width was chosen, minimizing f for this global weight. The concept was demonstrated in a planning study for a cylindrically symmetric example with a large range of different radii of an OAR along the patient axis. The method is discussed for some classes of tumor/organ at risk combinations. Noncylindrically symmetric cases were treated exemplarily. The product of width and weight of

  12. Is credit for early action credible early action?

    International Nuclear Information System (INIS)

    Rolfe, C.; Michaelowa, A.; Dutschke, M.

    1999-12-01

    Credit for early action as a tool for greenhouse gas emissions reduction is compared with various market instruments as a means of narrowing the gap between projected emissions and those of the Kyoto Protocol. Market instruments work by creating a market price for emissions and use the market to encourage reductions at the lowest price, which is done by placing limits on greenhouse gas emissions and allowing the market to decide where reductions occur, or by imposing a carbon tax or emissions charge. While they can be applied within a sector, they are usually used to encourage reductions throughout the economy or across large sectors. Credit for early action also creates an incentive for emissions reductions throughout the economy or at least across many sectors. Credit for early action tools do not work by either imposing a carbon tax or emissions charge or placing limits on emissions, rather they promise that entities that take action against greenhouse gases prior to the imposition of a carbon tax or emissions limits will receive a credit against future taxes or limits. An overview is provided of the Kyoto Protocol and the rationale for taking early action, and a review is included of the theory and specific proposals for market instruments and credit for early action. A comparative analysis is provided of these approaches by examining their relative efficiency, environmental effectiveness, and impacts on the redistribution of wealth. Credit for early action is viewed as problematic on a number of counts and is seen as an interim strategy for imposition while political support for market instruments develop. The environmental effectiveness of credit for early action is very difficult to predict, and credit for early action programs do not yield the lowest cost emissions reductions. Credit for early action programs will not achieve compliance with the Kyoto Protocol at the lowest cost, and credits for early action will increase the compliance costs for those who

  13. Microprocessor controller for stepping motors

    International Nuclear Information System (INIS)

    Strait, B.G.; Thuot, M.E.

    1977-01-01

    A new concept for digital computer control of multiple stepping motors which operate in a severe electromagnetic pulse environment is presented. The motors position mirrors in the beam-alignment system of a 100-kJ CO 2 laser. An asynchronous communications channel of a computer is used to send coded messages, containing the motor address and stepping-command information, to the stepping-motor controller in a bit serial format over a fiber-optics communications link. The addressed controller responds by transmitting to the computer its address and other motor information, thus confirming the received message. Each controller is capable of controlling three stepping motors. The controller contains the fiber-optics interface, a microprocessor, and the stepping-motor driven circuits. The microprocessor program, which resides in an EPROM, decodes the received messages, transmits responses, performs the stepping-motor sequence logic, maintains motor-position information, and monitors the motor's reference switch. For multiple stepping-motor application, the controllers are connected in a daisy chain providing control of many motors from one asynchronous communications channel of the computer

  14. ActionMap: A web-based software that automates loci assignments to framework maps.

    Science.gov (United States)

    Albini, Guillaume; Falque, Matthieu; Joets, Johann

    2003-07-01

    Genetic linkage computation may be a repetitive and time consuming task, especially when numerous loci are assigned to a framework map. We thus developed ActionMap, a web-based software that automates genetic mapping on a fixed framework map without adding the new markers to the map. Using this tool, hundreds of loci may be automatically assigned to the framework in a single process. ActionMap was initially developed to map numerous ESTs with a small plant mapping population and is limited to inbred lines and backcrosses. ActionMap is highly configurable and consists of Perl and PHP scripts that automate command steps for the MapMaker program. A set of web forms were designed for data import and mapping settings. Results of automatic mapping can be displayed as tables or drawings of maps and may be exported. The user may create personal access-restricted projects to store raw data, settings and mapping results. All data may be edited, updated or deleted. ActionMap may be used either online or downloaded for free (http://moulon.inra.fr/~bioinfo/).

  15. Steps in preparing and biodiversity section of climate change action plan. Development and evolution of forestry and biodiversity mitigation measures

    International Nuclear Information System (INIS)

    DiNicola, A.

    1997-01-01

    Methodic for drawing up of national action plans on prevention of unfavorable consequences of climate change in forestry is described. Approaches to development and measures evolution in these fields on greenhouse effect reduce are considered. (author)

  16. Energetics of highly kinked step edges

    NARCIS (Netherlands)

    Zandvliet, Henricus J.W.

    2010-01-01

    We have determined the step edge free energy, the step edge stiffness and dimensionless inverse step edge stiffness of the highly kinked < 010> oriented step on a (001) surface of a simple square lattice within the framework of a solid-on-solid model. We have found an exact expression for the step

  17. Acomparative Study Comparing Low-dose Step-up Versus Step-down in Polycystic Ovary Syndrome Resistant to Clomiphene

    Directory of Open Access Journals (Sweden)

    S Peivandi

    2010-03-01

    Full Text Available Introduction: Polycystic ovary syndrome(PCOS is one of the most common cause of infertility in women. clomiphene is the first line of treatment. however 20% of patients are resistant to clomiphene. because of follicular hypersensitivity to gonadotropins in pcod, multiple follicular growth and development occurs which is cause of OHSS and multiple pregnancy. Our aim of this random and clinical study was comparation between step-down and low dose step-up methods for induction ovulation in clomiphene resistant. Methods: 60 cases were included 30 women in low-dose step-up group and 30 women in step-down group. In low-dose step-up HMG 75u/d and in step-down HMG 225u/d was started on 3th days of cycle, monitoring with vaginal sonography was done on 8th days of cycle. When follicle with>14 mm in diameter was seen HMG dose was continued in low-dose step-up and was decreased in step-down group. When follicle reached to 18mm in diameter, amp HCG 10000 unit was injected and IUI was performed 36 hours later. Results: Number of HMG ampules, number of follicles> 14mm on the day of HCG injection and level of serum estradiol was greater in low dose step up protocol than step down protocol(p<0/0001. Ovulation rate and pregnancy rate was greater in lowdose step up group than step down group with significant difference (p<0/0001. Conclusion: Our study showed that low-dose step-up regimen with HMG is effective for stimulating ovulation and clinical pregnancy but in view of monofollicular growth, the step down method was more effective and safe. In our study multifolliular growth in step-up method was higher than step-down method. We can predict possibility of Ovarian Hyperstimulation Syndrome syndrome in highly sensitive PCOS patients.

  18. Microsoft Office SharePoint Designer 2007 Step by Step

    CERN Document Server

    Coventry, Penelope

    2008-01-01

    The smart way to learn Office SharePoint Designer 2007-one step at a time! Work at your own pace through the easy numbered steps, practice files on CD, helpful hints, and troubleshooting tips to master the fundamentals of building customized SharePoint sites and applications. You'll learn how to work with Windows® SharePoint Services 3.0 and Office SharePoint Server 2007 to create Web pages complete with Cascading Style Sheets, Lists, Libraries, and customized Web parts. Then, make your site really work for you by adding data sources, including databases, XML data and Web services, and RSS fe

  19. Microsoft Windows Sharepoint Services 3.0 Step by Step

    CERN Document Server

    Londer, Olga; Bleeker, Todd; Coventry, Penelope

    2007-01-01

    Experience learning made easy-and quickly teach yourself how to use Windows SharePoint Services to enable effective team collaboration. With Step By Step, you set the pace-building and practicing the skills you need, just when you need them! Build your own SharePoint site with easy-to-use templatesCreate lists and libraries to store informationAdd discussion boards, wikis, and blogsSet up Document and Meeting Workspaces for easy collaborationShare calendars, contacts, and data from Microsoft Office programsCustomize your pages with Web Parts Your all-in-one learning experience includes: Fi

  20. Critical utopian action research and the power of future creating workshops

    DEFF Research Database (Denmark)

    Husted, Mia; Tofteng, Ditte Maria Børglum

    in a participatory process of democratic development of everyday life. Critical utopian action research is characterized by a methodological preference to the future creating workshop as a method that captures the scientific theoretical approach: The future creating workshop outline a specific method originally...... in upturned-participation. Within traditional participatory planning we talk about a participatory ladder. The steps on the ladder reflects how one can participate in different scales an ways, from being merely an informant to being self-determining and performing. The ladder tells us notion about who...... of exploring, developing and analyzing is a common project between the participant and the researchers. Conclusions: When stressing critique and utopian ideas within upturned participatory processes as the starting point, the CUAR tradition brings new input to the wider society of action research, insisting...

  1. Distributed representations of action sequences in anterior cingulate cortex: A recurrent neural network approach.

    Science.gov (United States)

    Shahnazian, Danesh; Holroyd, Clay B

    2018-02-01

    Anterior cingulate cortex (ACC) has been the subject of intense debate over the past 2 decades, but its specific computational function remains controversial. Here we present a simple computational model of ACC that incorporates distributed representations across a network of interconnected processing units. Based on the proposal that ACC is concerned with the execution of extended, goal-directed action sequences, we trained a recurrent neural network to predict each successive step of several sequences associated with multiple tasks. In keeping with neurophysiological observations from nonhuman animals, the network yields distributed patterns of activity across ACC neurons that track the progression of each sequence, and in keeping with human neuroimaging data, the network produces discrepancy signals when any step of the sequence deviates from the predicted step. These simulations illustrate a novel approach for investigating ACC function.

  2. Delivery 7 Report on the impact of conflicts/synergies and policy proposals for implementing the EU Action Plan in member states

    DEFF Research Database (Denmark)

    Beck, Anne-Marie Tyroll; Michelsen, Johannes

    This report on “Implementing the European Organic Action Plan in EU member states - stakeholders’ perceptions of implementation problems and coping strategies” recapitulates the results of a series of national workshops undertaken in winter/spring 2007. It brings together very different views...... and perceptions on organic action plans and possible evaluation methodologies and can be seen as ORGAP’s stakeholder oriented or public oriented step....

  3. Comparative analysis of single-step and two-step biodiesel production using supercritical methanol on laboratory-scale

    International Nuclear Information System (INIS)

    Micic, Radoslav D.; Tomić, Milan D.; Kiss, Ferenc E.; Martinovic, Ferenc L.; Simikić, Mirko Ð.; Molnar, Tibor T.

    2016-01-01

    Highlights: • Single-step supercritical transesterification compared to the two-step process. • Two-step process: oil hydrolysis and subsequent supercritical methyl esterification. • Experiments were conducted in a laboratory-scale batch reactor. • Higher biodiesel yields in two-step process at milder reaction conditions. • Two-step process has potential to be cost-competitive with the single-step process. - Abstract: Single-step supercritical transesterification and two-step biodiesel production process consisting of oil hydrolysis and subsequent supercritical methyl esterification were studied and compared. For this purpose, comparative experiments were conducted in a laboratory-scale batch reactor and optimal reaction conditions (temperature, pressure, molar ratio and time) were determined. Results indicate that in comparison to a single-step transesterification, methyl esterification (second step of the two-step process) produces higher biodiesel yields (95 wt% vs. 91 wt%) at lower temperatures (270 °C vs. 350 °C), pressures (8 MPa vs. 12 MPa) and methanol to oil molar ratios (1:20 vs. 1:42). This can be explained by the fact that the reaction system consisting of free fatty acid (FFA) and methanol achieves supercritical condition at milder reaction conditions. Furthermore, the dissolved FFA increases the acidity of supercritical methanol and acts as an acid catalyst that increases the reaction rate. There is a direct correlation between FFA content of the product obtained in hydrolysis and biodiesel yields in methyl esterification. Therefore, the reaction parameters of hydrolysis were optimized to yield the highest FFA content at 12 MPa, 250 °C and 1:20 oil to water molar ratio. Results of direct material and energy costs comparison suggest that the process based on the two-step reaction has the potential to be cost-competitive with the process based on single-step supercritical transesterification. Higher biodiesel yields, similar or lower energy

  4. HTSC-Josephson step contacts

    International Nuclear Information System (INIS)

    Herrmann, K.

    1994-03-01

    In this work the properties of josephson step contacts are investigated. After a short introduction into Josephson step contacts the structure, properties and the Josphson contacts of YBa 2 Cu 3 O 7-x high-T c superconductors is presented. The fabrication of HTSC step contacts and the microstructure is discussed. The electric properties of these contacts are measured together with the Josephson emission and the magnetic field dependence. The temperature dependence of the stationary transport properties is given. (WL)

  5. Action-based flood forecasting for triggering humanitarian action

    Science.gov (United States)

    Coughlan de Perez, Erin; van den Hurk, Bart; van Aalst, Maarten K.; Amuron, Irene; Bamanya, Deus; Hauser, Tristan; Jongma, Brenden; Lopez, Ana; Mason, Simon; Mendler de Suarez, Janot; Pappenberger, Florian; Rueth, Alexandra; Stephens, Elisabeth; Suarez, Pablo; Wagemaker, Jurjen; Zsoter, Ervin

    2016-09-01

    Too often, credible scientific early warning information of increased disaster risk does not result in humanitarian action. With financial resources tilted heavily towards response after a disaster, disaster managers have limited incentive and ability to process complex scientific data, including uncertainties. These incentives are beginning to change, with the advent of several new forecast-based financing systems that provide funding based on a forecast of an extreme event. Given the changing landscape, here we demonstrate a method to select and use appropriate forecasts for specific humanitarian disaster prevention actions, even in a data-scarce location. This action-based forecasting methodology takes into account the parameters of each action, such as action lifetime, when verifying a forecast. Forecasts are linked with action based on an understanding of (1) the magnitude of previous flooding events and (2) the willingness to act "in vain" for specific actions. This is applied in the context of the Uganda Red Cross Society forecast-based financing pilot project, with forecasts from the Global Flood Awareness System (GloFAS). Using this method, we define the "danger level" of flooding, and we select the probabilistic forecast triggers that are appropriate for specific actions. Results from this methodology can be applied globally across hazards and fed into a financing system that ensures that automatic, pre-funded early action will be triggered by forecasts.

  6. Solar-driven thermo- and electrochemical degradation of nitrobenzene in wastewater: Adaptation and adoption of solar STEP concept

    International Nuclear Information System (INIS)

    Gu, Di; Shao, Nan; Zhu, Yanji; Wu, Hongjun; Wang, Baohui

    2017-01-01

    Highlights: • STEP for NB treatment was established without input of energy and chemicals. • Treatment of NB was theoretically and experimentally studied by STEP. • The results demonstrated that STEP is more efficient than classical AOPs. • The mechanism of STEP was illustratively presented for NB wastewater. - Abstract: The STEP concept has successfully been demonstrated for driving chemical reaction by utilization of solar heat and electricity to minimize the fossil energy, meanwhile, maximize the rate of thermo- and electrochemical reactions in thermodynamics and kinetics. This pioneering investigation experimentally exhibit that the STEP concept is adapted and adopted efficiently for degradation of nitrobenzene. By employing the theoretical calculation and thermo-dependent cyclic voltammetry, the degradation potential of nitrobenzene was found to be decreased obviously, at the same time, with greatly lifting the current, while the temperature was increased. Compared with the conventional electrochemical methods, high efficiency and fast degradation rate were markedly displayed due to the co-action of thermo- and electrochemical effects and the switch of the indirect electrochemical oxidation to the direct one for oxidation of nitrobenzene. A clear conclusion on the mechanism of nitrobenzene degradation by the STEP can be schematically proposed and discussed by the combination of thermo- and electrochemistry based the analysis of the HPLC, UV–vis and degradation data. This theory and experiment provide a pilot for the treatment of nitrobenzene wastewater with high efficiency, clean operation and low carbon footprint, without any other input of energy and chemicals from solar energy.

  7. Solar-driven thermo- and electrochemical degradation of nitrobenzene in wastewater: Adaptation and adoption of solar STEP concept

    Energy Technology Data Exchange (ETDEWEB)

    Gu, Di; Shao, Nan; Zhu, Yanji; Wu, Hongjun; Wang, Baohui, E-mail: wangbh@nepu.edu.cn

    2017-01-05

    Highlights: • STEP for NB treatment was established without input of energy and chemicals. • Treatment of NB was theoretically and experimentally studied by STEP. • The results demonstrated that STEP is more efficient than classical AOPs. • The mechanism of STEP was illustratively presented for NB wastewater. - Abstract: The STEP concept has successfully been demonstrated for driving chemical reaction by utilization of solar heat and electricity to minimize the fossil energy, meanwhile, maximize the rate of thermo- and electrochemical reactions in thermodynamics and kinetics. This pioneering investigation experimentally exhibit that the STEP concept is adapted and adopted efficiently for degradation of nitrobenzene. By employing the theoretical calculation and thermo-dependent cyclic voltammetry, the degradation potential of nitrobenzene was found to be decreased obviously, at the same time, with greatly lifting the current, while the temperature was increased. Compared with the conventional electrochemical methods, high efficiency and fast degradation rate were markedly displayed due to the co-action of thermo- and electrochemical effects and the switch of the indirect electrochemical oxidation to the direct one for oxidation of nitrobenzene. A clear conclusion on the mechanism of nitrobenzene degradation by the STEP can be schematically proposed and discussed by the combination of thermo- and electrochemistry based the analysis of the HPLC, UV–vis and degradation data. This theory and experiment provide a pilot for the treatment of nitrobenzene wastewater with high efficiency, clean operation and low carbon footprint, without any other input of energy and chemicals from solar energy.

  8. Learning, attentional control and action video games

    Science.gov (United States)

    Green, C.S.; Bavelier, D.

    2012-01-01

    While humans have an incredible capacity to acquire new skills and alter their behavior as a result of experience, enhancements in performance are typically narrowly restricted to the parameters of the training environment, with little evidence of generalization to different, even seemingly highly related, tasks. Such specificity is a major obstacle for the development of many real-world training or rehabilitation paradigms, which necessarily seek to promote more general learning. In contrast to these typical findings, research over the past decade has shown that training on ‘action video games’ produces learning that transfers well beyond the training task. This has led to substantial interest among those interested in rehabilitation, for instance, after stroke or to treat amblyopia, or training for various precision-demanding jobs, for instance, endoscopic surgery or piloting unmanned aerial drones. Although the predominant focus of the field has been on outlining the breadth of possible action-game-related enhancements, recent work has concentrated on uncovering the mechanisms that underlie these changes, an important first step towards the goal of designing and using video games for more definite purposes. Game playing may not convey an immediate advantage on new tasks (increased performance from the very first trial), but rather the true effect of action video game playing may be to enhance the ability to learn new tasks. Such a mechanism may serve as a signature of training regimens that are likely to produce transfer of learning. PMID:22440805

  9. Everyday robotic action: Lessons from human action control

    Directory of Open Access Journals (Sweden)

    Roy eDe Kleijn

    2014-03-01

    Full Text Available Robots are increasingly capable of performing everyday human activities such as cooking, cleaning, and doing the laundry. This requires the real-time planning and execution of complex, temporally-extended sequential actions under high degrees of uncertainty, which provides many challenges to traditional approaches to robot action control. We argue that important lessons in this respect can be learned from research on human action control. We provide a brief overview of available psychological insights into this issue and focus on four principles that we think could be particularly beneficial for robot control: the integration of symbolic and subsymbolic planning of action sequences, the integration of feedforward and feedback control, the clustering of complex actions into subcomponents, and the contextualization of action-control structures through goal representations.

  10. ONE-STEP AND TWO-STEP CALIBRATION OF A PORTABLE PANORAMIC IMAGE MAPPING SYSTEM

    Directory of Open Access Journals (Sweden)

    P.-C. Wang

    2012-07-01

    Full Text Available A Portable Panoramic Image Mapping System (PPIMS is proposed for rapid acquisition of three-dimensional spatial information. By considering the convenience of use, cost, weight of equipment, precision, and power supply, the designed PPIMS is equipped with 6 circularly arranged cameras to capture panoramic images and a GPS receiver for positioning. The motivation for this design is to develop a hand-held Mobile Mapping System (MMS for some difficult accessing areas by vehicle MMS, such as rugged terrains, forest areas, heavily damaged disaster areas, and crowed places etc. This PPIMS is in fact a GPS assisted close-range photogrammetric system. Compared with the traditional close-range photogrammetry, PPIMS can reduce the need of ground control points significantly. Under the condition of knowing the relative geometric relationships of the equipped sensors, the elements of exterior orientation of each captured image can be solved. However, the procedure of a system calibration should be done accurately to determine the relative geometric relationships of multi-cameras and the GPS antenna center, before the PPIMS can be applied for geo-referenced mapping. In this paper, both of one-step and two-step calibration procedures for PPIMS are performed to determine the lever-arm offsets and boresight angles among cameras and GPS. The performance of the one-step and two-step calibration is evaluated through the analysis of the experimental results. The comparison between these two calibration procedures was also conducted. The two-step calibration method outperforms the one-step calibration method in terms of calibration accuracy and operation convenience. We expect that the proposed two-step calibration procedure can also be applied to other platform-based MMSs.

  11. Step-to-step spatiotemporal variables and ground reaction forces of intra-individual fastest sprinting in a single session.

    Science.gov (United States)

    Nagahara, Ryu; Mizutani, Mirai; Matsuo, Akifumi; Kanehisa, Hiroaki; Fukunaga, Tetsuo

    2018-06-01

    We aimed to investigate the step-to-step spatiotemporal variables and ground reaction forces during the acceleration phase for characterising intra-individual fastest sprinting within a single session. Step-to-step spatiotemporal variables and ground reaction forces produced by 15 male athletes were measured over a 50-m distance during repeated (three to five) 60-m sprints using a long force platform system. Differences in measured variables between the fastest and slowest trials were examined at each step until the 22nd step using a magnitude-based inferences approach. There were possibly-most likely higher running speed and step frequency (2nd to 22nd steps) and shorter support time (all steps) in the fastest trial than in the slowest trial. Moreover, for the fastest trial there were likely-very likely greater mean propulsive force during the initial four steps and possibly-very likely larger mean net anterior-posterior force until the 17th step. The current results demonstrate that better sprinting performance within a single session is probably achieved by 1) a high step frequency (except the initial step) with short support time at all steps, 2) exerting a greater mean propulsive force during initial acceleration, and 3) producing a greater mean net anterior-posterior force during initial and middle acceleration.

  12. Corrective Action Investigation Plan for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada (December 2002, Revision No.: 0), Including Record of Technical Change No. 1

    Energy Technology Data Exchange (ETDEWEB)

    NNSA/NSO

    2002-12-12

    , and step-out sampling to define the extent of contamination, as necessary. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document.

  13. Educational actions of energy control. Good practices of european towns; Les actions educatives de maitrise de l'energie. Bonnes pratiques de villes europeennes

    Energy Technology Data Exchange (ETDEWEB)

    Maurer, Ch.

    2001-07-01

    In the framework of an energy policy against the greenhouse effect, the young people awareness to the energy conservation and the environment protection, is essential because they will be the citizens of tomorrow and in a first step, they can have influence on their parents attitude. This study presents and analyzes ten experiences of european towns concerning: the utilization or the creation of educational tools as CD-Rom, Internet, documents; operations associating teachers and students at energy control actions in their school; operations associating external interveners of the school. (A.L.B.)

  14. Hearing sounds, understanding actions: action representation in mirror neurons.

    Science.gov (United States)

    Kohler, Evelyne; Keysers, Christian; Umiltà, M Alessandra; Fogassi, Leonardo; Gallese, Vittorio; Rizzolatti, Giacomo

    2002-08-02

    Many object-related actions can be recognized by their sound. We found neurons in monkey premotor cortex that discharge when the animal performs a specific action and when it hears the related sound. Most of the neurons also discharge when the monkey observes the same action. These audiovisual mirror neurons code actions independently of whether these actions are performed, heard, or seen. This discovery in the monkey homolog of Broca's area might shed light on the origin of language: audiovisual mirror neurons code abstract contents-the meaning of actions-and have the auditory access typical of human language to these contents.

  15. Linear, Step by Step Managerial Performance, versus Exponential Performance

    Directory of Open Access Journals (Sweden)

    George MOLDOVEANU

    2011-04-01

    Full Text Available The paper proposes the transition from the potential management concept, which its authors approached by determining its dimension (Roşca, Moldoveanu, 2009b, to the linear, step by step performance concept, as an objective result of management process. In this way, we “answer” the theorists and practitioners, who support exponential management performance. The authors, as detractors of the exponential performance, are influenced by the current crisis (Roşca, Moldoveanu, 2009a, by the lack of organizational excellence in many companies, particularly in Romanian ones and also reaching “the finality” in the evolved companies, developed into an uncontrollable speed.

  16. A step-by-step methodology for enterprise interoperability projects

    Science.gov (United States)

    Chalmeta, Ricardo; Pazos, Verónica

    2015-05-01

    Enterprise interoperability is one of the key factors for enhancing enterprise competitiveness. Achieving enterprise interoperability is an extremely complex process which involves different technological, human and organisational elements. In this paper we present a framework to help enterprise interoperability. The framework has been developed taking into account the three domains of interoperability: Enterprise Modelling, Architecture and Platform and Ontologies. The main novelty of the framework in comparison to existing ones is that it includes a step-by-step methodology that explains how to carry out an enterprise interoperability project taking into account different interoperability views, like business, process, human resources, technology, knowledge and semantics.

  17. Comparison of step-by-step kinematics in repeated 30m sprints in female soccer players.

    Science.gov (United States)

    van den Tillaar, Roland

    2018-01-04

    The aim of this study was to compare kinematics in repeated 30m sprints in female soccer players. Seventeen subjects performed seven 30m sprints every 30s in one session. Kinematics were measured with an infrared contact mat and laser gun, and running times with an electronic timing device. The main findings were that sprint times increased in the repeated sprint ability test. The main changes in kinematics during the repeated sprint ability test were increased contact time and decreased step frequency, while no change in step length was observed. The step velocity increased in almost each step until the 14, which occurred around 22m. After this, the velocity was stable until the last step, when it decreased. This increase in step velocity was mainly caused by the increased step length and decreased contact times. It was concluded that the fatigue induced in repeated 30m sprints in female soccer players resulted in decreased step frequency and increased contact time. Employing this approach in combination with a laser gun and infrared mat for 30m makes it very easy to analyse running kinematics in repeated sprints in training. This extra information gives the athlete, coach and sports scientist the opportunity to give more detailed feedback and help to target these changes in kinematics better to enhance repeated sprint performance.

  18. Adsorption-induced step formation

    DEFF Research Database (Denmark)

    Thostrup, P.; Christoffersen, Ebbe; Lorensen, Henrik Qvist

    2001-01-01

    Through an interplay between density functional calculations, Monte Carlo simulations and scanning tunneling microscopy experiments, we show that an intermediate coverage of CO on the Pt(110) surface gives rise to a new rough equilibrium structure with more than 50% step atoms. CO is shown to bind...... so strongly to low-coordinated Pt atoms that it can break Pt-Pt bonds and spontaneously form steps on the surface. It is argued that adsorption-induced step formation may be a general effect, in particular at high gas pressures and temperatures....

  19. Critical flux determination by flux-stepping

    DEFF Research Database (Denmark)

    Beier, Søren; Jonsson, Gunnar Eigil

    2010-01-01

    In membrane filtration related scientific literature, often step-by-step determined critical fluxes are reported. Using a dynamic microfiltration device, it is shown that critical fluxes determined from two different flux-stepping methods are dependent upon operational parameters such as step...... length, step height, and.flux start level. Filtrating 8 kg/m(3) yeast cell suspensions by a vibrating 0.45 x 10(-6) m pore size microfiltration hollow fiber module, critical fluxes from 5.6 x 10(-6) to 1.2 x 10(-5) m/s have been measured using various step lengths from 300 to 1200 seconds. Thus......, such values are more or less useless in itself as critical flux predictors, and constant flux verification experiments have to be conducted to check if the determined critical fluxes call predict sustainable flux regimes. However, it is shown that using the step-by-step predicted critical fluxes as start...

  20. Linking pedestrian flow characteristics with stepping locomotion

    Science.gov (United States)

    Wang, Jiayue; Boltes, Maik; Seyfried, Armin; Zhang, Jun; Ziemer, Verena; Weng, Wenguo

    2018-06-01

    While properties of human traffic flow are described by speed, density and flow, the locomotion of pedestrian is based on steps. To relate characteristics of human locomotor system with properties of human traffic flow, this paper aims to connect gait characteristics like step length, step frequency, swaying amplitude and synchronization with speed and density and thus to build a ground for advanced pedestrian models. For this aim, observational and experimental study on the single-file movement of pedestrians at different densities is conducted. Methods to measure step length, step frequency, swaying amplitude and step synchronization are proposed by means of trajectories of the head. Mathematical models for the relations of step length or frequency and speed are evaluated. The problem how step length and step duration are influenced by factors like body height and density is investigated. It is shown that the effect of body height on step length and step duration changes with density. Furthermore, two different types of step in-phase synchronization between two successive pedestrians are observed and the influence of step synchronization on step length is examined.

  1. Toward effective ecological risk-management of refinery corrective action

    International Nuclear Information System (INIS)

    Metzger, B.H.; Rury, P.M.; Turton, D.; Archibald, B.; Clark, J.; Cura, J.

    1995-01-01

    Cleanup of complex industrial sites, such as refineries, requires risk-based decision tools to ensure that environmentally protective remediation is consistent with current and future land use. However, conventional ecological risk assessment approaches are not well suited for complex industrial sites. Site risk assessments focus on hypothetical chemical risk assuming diverse and undisturbed ecosystems, rather than industrial and disturbed area conditions. In addition, they offer little guidance as to how to make timely and effective risk management decisions. An innovative methodology is proposed to assist industry and regulatory risk managers with rapid EcoRisk reconnaissance and cost-effective remedial decision-making at complex industrial sites. Phase 1 comprises a three-step risk screening of areas of ecological concern at the site, which integrates habitat quality characteristics and potential chemical hazards. It yields an ordering of areas as follows: areas of no significant risk; areas of potentially significant risk; and areas of likely significant risk. A decision rule is then applied to determine appropriate risk management action, including: no action; additional study; and remedial or management action. In Phase 2, additional study is conducted for areas that exhibit potentially significant risk so as to facilitate risk management. This methodology is currently being applied at the 1,300 acre, former Exxon Bayway Refinery in New Jersey

  2. A step-by-step guide to systematically identify all relevant animal studies

    Science.gov (United States)

    Leenaars, Marlies; Hooijmans, Carlijn R; van Veggel, Nieky; ter Riet, Gerben; Leeflang, Mariska; Hooft, Lotty; van der Wilt, Gert Jan; Tillema, Alice; Ritskes-Hoitinga, Merel

    2012-01-01

    Before starting a new animal experiment, thorough analysis of previously performed experiments is essential from a scientific as well as from an ethical point of view. The method that is most suitable to carry out such a thorough analysis of the literature is a systematic review (SR). An essential first step in an SR is to search and find all potentially relevant studies. It is important to include all available evidence in an SR to minimize bias and reduce hampered interpretation of experimental outcomes. Despite the recent development of search filters to find animal studies in PubMed and EMBASE, searching for all available animal studies remains a challenge. Available guidelines from the clinical field cannot be copied directly to the situation within animal research, and although there are plenty of books and courses on searching the literature, there is no compact guide available to search and find relevant animal studies. Therefore, in order to facilitate a structured, thorough and transparent search for animal studies (in both preclinical and fundamental science), an easy-to-use, step-by-step guide was prepared and optimized using feedback from scientists in the field of animal experimentation. The step-by-step guide will assist scientists in performing a comprehensive literature search and, consequently, improve the scientific quality of the resulting review and prevent unnecessary animal use in the future. PMID:22037056

  3. Mental Health in the Workplace: A Call to Action Proceedings from the Mental Health in the Workplace: Public Health Summit

    Science.gov (United States)

    Goetzel, Ron Z.; Roemer, Enid Chung; Holingue, Calliope; Fallin, M. Daniele; McCleary, Katherine; Eaton, William; Agnew, Jacqueline; Azocar, Francisca; Ballard, David; Bartlett, John; Braga, Michael; Conway, Heidi; Crighton, K. Andrew; Frank, Richard; Jinnett, Kim; Keller-Greene, Debra; Rauch, Sara Martin; Safeer, Richard; Saporito, Dick; Schill, Anita; Shern, David; Strecher, Victor; Wald, Peter; Wang, Philip; Mattingly, C. Richard

    2018-01-01

    Objective To declare a call to action to improve mental health in the workplace. Methods We convened a public health summit and assembled an Advisory Council consisting of experts in the field of occupational health and safety, workplace wellness, and public policy to offer recommendations for action steps to improve health and well-being of workers. Results The Advisory Council narrowed the list of ideas to four priority projects. Conclusions The recommendations for action include developing a Mental Health in the Workplace 1) “How to” Guide, 2) Scorecard, 3) Recognition Program, and 4) Executive Training. PMID:29280775

  4. The scaup conservation action plan: working toward coherence

    Science.gov (United States)

    Austin, Jane E.

    2010-01-01

    The last in a series of three workshops to develop a decision framework for the scaup conservation action plan was conducted in September 2009. Fifteen waterfowl biologists and managers met in Memphis, Tennessee at the Ducks Unlimited Headquarters to review and refine the decision statement, objectives, and prototype model for the continental scaup population, with a special focus on vital rate parameters that are affected during migration and winter. In a significant step toward coherence, the participants also developed models for incorporating human dimensions – hunters – into the decision framework, and to link the population of diving duck hunters with the continental scaup population.

  5. Recovery of forward stepping in spinal cord injured patients does not transfer to untrained backward stepping.

    Science.gov (United States)

    Grasso, Renato; Ivanenko, Yuri P; Zago, Myrka; Molinari, Marco; Scivoletto, Giorgio; Lacquaniti, Francesco

    2004-08-01

    Six spinal cord injured (SCI) patients were trained to step on a treadmill with body-weight support for 1.5-3 months. At the end of training, foot motion recovered the shape and the step-by-step reproducibility that characterize normal gait. They were then asked to step backward on the treadmill belt that moved in the opposite direction relative to standard forward training. In contrast to healthy subjects, who can immediately reverse the direction of walking by time-reversing the kinematic waveforms, patients were unable to step backward. Similarly patients were unable to perform another untrained locomotor task, namely stepping in place on the idle treadmill. Two patients who were trained to step backward for 2-3 weeks were able to develop control of foot motion appropriate for this task. The results show that locomotor improvement does not transfer to untrained tasks, thus supporting the idea of task-dependent plasticity in human locomotor networks.

  6. Determination of the step dipole moment and the step line tension on Ag(0 0 1) electrodes

    International Nuclear Information System (INIS)

    Beltramo, G.L.; Ibach, H.; Linke, U.; Giesen, M.

    2008-01-01

    Using impedance spectroscopy, we determined the step dipole moment and the potential dependence of the step line tension of silver electrodes in contact with an electrolyte: (0 0 1) and vicinal surfaces (1 1 n) with n = 5, 7, 11 in 10 mM ClO 4 - -solutions were investigated. The step dipole moment is determined from the shift of the potential of zero charge (pzc) as a function of the surface step density. The dipole moment per step atom was found to be 3.5 ± 0.5 x 10 -3 e A. From the pzc and the potential dependence of the capacitance curves, the potential dependence of the surface tension of the vicinal surfaces is determined. The line tension of the steps is then calculated from the difference between the surface tensions of stepped (1 1 n) and the nominally step-free (0 0 1) surfaces. The results are compared to a previous study on Au(1 1 n) surfaces. For gold, the step line tension decreases roughly linear with potential, whereas a parabolic shape is observed for silver

  7. Finding minimal action sequences with a simple evaluation of actions

    Science.gov (United States)

    Shah, Ashvin; Gurney, Kevin N.

    2014-01-01

    Animals are able to discover the minimal number of actions that achieves an outcome (the minimal action sequence). In most accounts of this, actions are associated with a measure of behavior that is higher for actions that lead to the outcome with a shorter action sequence, and learning mechanisms find the actions associated with the highest measure. In this sense, previous accounts focus on more than the simple binary signal of “was the outcome achieved?”; they focus on “how well was the outcome achieved?” However, such mechanisms may not govern all types of behavioral development. In particular, in the process of action discovery (Redgrave and Gurney, 2006), actions are reinforced if they simply lead to a salient outcome because biological reinforcement signals occur too quickly to evaluate the consequences of an action beyond an indication of the outcome's occurrence. Thus, action discovery mechanisms focus on the simple evaluation of “was the outcome achieved?” and not “how well was the outcome achieved?” Notwithstanding this impoverishment of information, can the process of action discovery find the minimal action sequence? We address this question by implementing computational mechanisms, referred to in this paper as no-cost learning rules, in which each action that leads to the outcome is associated with the same measure of behavior. No-cost rules focus on “was the outcome achieved?” and are consistent with action discovery. No-cost rules discover the minimal action sequence in simulated tasks and execute it for a substantial amount of time. Extensive training, however, results in extraneous actions, suggesting that a separate process (which has been proposed in action discovery) must attenuate learning if no-cost rules participate in behavioral development. We describe how no-cost rules develop behavior, what happens when attenuation is disrupted, and relate the new mechanisms to wider computational and biological context. PMID:25506326

  8. Hybrid Action Systems

    DEFF Research Database (Denmark)

    Rönnkö, M.; Ravn, Anders Peter; Sere, K.

    2003-01-01

    In this paper we investigate the use of action systems with differential actions in the specifcation of hybrid systems. As the main contribution we generalize the definition of a differential action, allowing the use of arbitrary relations over model variables and their time......-derivatives in modelling continuous-time dynamics. The generalized differential action has an intuitively appealing predicate transformer semantics, which we show to be both conjunctive and monotonic. In addition, we show that differential actions blend smoothly with conventional actions in action systems, even under...... parallel composition. Moreover, as the strength of the action system formalism is the support for stepwise development by refinement, we investigate refinement involving a differential action. We show that, due to the predicate transformer semantics, standard action refinement techniques apply also...

  9. Development process and data management of TurnSTEP, a STEP-compliant CNC system for turning

    NARCIS (Netherlands)

    Choi, I.; Suh, S.-H; Kim, K.; Song, M.S.; Jang, M.; Lee, B.-E.

    2006-01-01

    TurnSTEP is one of the earliest STEP-compliant CNC systems for turning. Based on the STEP-NC data model formalized as ISO 14649-12 and 121, it is designed to support intelligent and autonomous control of NC machines for e-manufacturing. The present paper introduces the development process and data

  10. Corrective Action Investigation Plan for Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada National Security Site, Nevada with ROTCs 1, 2, and 3 (Revision 0, September 2000)

    Energy Technology Data Exchange (ETDEWEB)

    Andrews, Robert; Marutzky, Sam

    2000-09-01

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's) approach to collect the data necessary to evaluate Corrective Action Alternatives (CAAs) appropriate for the closure of Corrective Action Unit (CAU) 97 under the Federal Facility Agreement and Consent Order (FFACO). Corrective Action Unit 97, collectively known as the Yucca Flat/Climax Mine CAU, consists of 720 Corrective Action Sites (CASs). The Yucca Flat/Climax Mine CAU extends over several areas of the NTS and constitutes one of several areas used for underground nuclear testing in the past. The nuclear tests resulted in groundwater contamination in the vicinity as well as downgradient of the underground test areas. Based on site history, the Yucca Flat underground nuclear tests were conducted in alluvial, volcanic, and carbonate rocks; whereas, the Climax Mine tests were conducted in an igneous intrusion located in northern Yucca Flat. Particle-tracking simulations performed during the regional evaluation indicate that the local Climax Mine groundwater flow system merges into the much larger Yucca Flat groundwater flow systems during the 1,000-year time period of interest. Addressing these two areas jointly and simultaneously investigating them as a combined CAU has been determined the best way to proceed with corrective action investigation (CAI) activities. The purpose and scope of the CAI includes characterization activities and model development conducted in five major sequential steps designed to be consistent with FFACO Underground Test Area Project's strategy to predict the location of the contaminant boundary, develop and implement a corrective action, and close each CAU. The results of this field investigation will support a defensible evaluation of CAAs in the subsequent corrective action decision document.

  11. Galvanizing action: conclusions and next steps for mainstreaming zinc interventions in public health programs.

    Science.gov (United States)

    Brown, Kenneth H; Baker, Shawn K

    2009-03-01

    This paper summarizes the results of the foregoing reviews of the impact of different intervention strategies designed to enhance zinc nutrition, including supplementation, fortification, and dietary diversification or modification. Current evidence indicates a beneficial impact of such interventions on zinc status and zinc-related functional outcomes. Preventive zinc supplementation reduces the incidence of diarrhea and acute lower respiratory tract infection among young children, decreases mortality of children over 12 months of age, and increases growth velocity. Therapeutic zinc supplementation during episodes of diarrhea reduces the duration and severity of illness. Zinc fortification increases zinc intake and total absorbed zinc, and recent studies are beginning to confirm a positive impact of zinc fortification on indicators of population zinc status. To assist with the development of zinc intervention programs, more information is needed on the prevalence of zinc deficiency in different countries, and rigorous evaluations of the effectiveness of large-scale zinc intervention programs should be planned. Recommended steps for scaling up zinc intervention programs, with or without other micronutrients, are described. In summary, there is now clear evidence of the benefit of selected interventions to reduce the risk of zinc deficiency, and a global commitment is urgently needed to conduct systematic assessments of population zinc status and to develop interventions to control zinc deficiency in the context of existing public health and nutrition programs.

  12. Fostering Autonomy through Syllabus Design: A Step-by-Step Guide for Success

    Science.gov (United States)

    Ramírez Espinosa, Alexánder

    2016-01-01

    Promoting learner autonomy is relevant in the field of applied linguistics due to the multiple benefits it brings to the process of learning a new language. However, despite the vast array of research on how to foster autonomy in the language classroom, it is difficult to find step-by-step processes to design syllabi and curricula focused on the…

  13. Age-related differences in lower-limb force-time relation during the push-off in rapid voluntary stepping.

    Science.gov (United States)

    Melzer, I; Krasovsky, T; Oddsson, L I E; Liebermann, D G

    2010-12-01

    This study investigated the force-time relationship during the push-off stage of a rapid voluntary step in young and older healthy adults, to study the assumption that when balance is lost a quick step may preserve stability. The ability to achieve peak propulsive force within a short time is critical for the performance of such a quick powerful step. We hypothesized that older adults would achieve peak force and power in significantly longer times compared to young people, particularly during the push-off preparatory phase. Fifteen young and 15 older volunteers performed rapid forward steps while standing on a force platform. Absolute anteroposterior and body weight normalized vertical forces during the push-off in the preparation and swing phases were used to determine time to peak and peak force, and step power. Two-way analyses of variance ('Group' [young-older] by 'Phase' [preparation-swing]) were used to assess our hypothesis (P ≤ 0.05). Older people exerted lower peak forces (anteroposterior and vertical) than young adults, but not necessarily lower peak power. More significantly, they showed a longer time to peak force, particularly in the vertical direction during the preparation phase. Older adults generate propulsive forces slowly and reach lower magnitudes, mainly during step preparation. The time to achieve a peak force and power, rather than its actual magnitude, may account for failures in quickly performing a preventive action. Such delay may be associated with the inability to react and recruit muscles quickly. Thus, training elderly to step fast in response to relevant cues may be beneficial in the prevention of falls. Copyright © 2010 Elsevier Ltd. All rights reserved.

  14. Simple Plans or Sophisticated Habits? State, Transition and Learning Interactions in the Two-Step Task.

    Directory of Open Access Journals (Sweden)

    Thomas Akam

    2015-12-01

    Full Text Available The recently developed 'two-step' behavioural task promises to differentiate model-based from model-free reinforcement learning, while generating neurophysiologically-friendly decision datasets with parametric variation of decision variables. These desirable features have prompted its widespread adoption. Here, we analyse the interactions between a range of different strategies and the structure of transitions and outcomes in order to examine constraints on what can be learned from behavioural performance. The task involves a trade-off between the need for stochasticity, to allow strategies to be discriminated, and a need for determinism, so that it is worth subjects' investment of effort to exploit the contingencies optimally. We show through simulation that under certain conditions model-free strategies can masquerade as being model-based. We first show that seemingly innocuous modifications to the task structure can induce correlations between action values at the start of the trial and the subsequent trial events in such a way that analysis based on comparing successive trials can lead to erroneous conclusions. We confirm the power of a suggested correction to the analysis that can alleviate this problem. We then consider model-free reinforcement learning strategies that exploit correlations between where rewards are obtained and which actions have high expected value. These generate behaviour that appears model-based under these, and also more sophisticated, analyses. Exploiting the full potential of the two-step task as a tool for behavioural neuroscience requires an understanding of these issues.

  15. Simple Plans or Sophisticated Habits? State, Transition and Learning Interactions in the Two-Step Task.

    Science.gov (United States)

    Akam, Thomas; Costa, Rui; Dayan, Peter

    2015-12-01

    The recently developed 'two-step' behavioural task promises to differentiate model-based from model-free reinforcement learning, while generating neurophysiologically-friendly decision datasets with parametric variation of decision variables. These desirable features have prompted its widespread adoption. Here, we analyse the interactions between a range of different strategies and the structure of transitions and outcomes in order to examine constraints on what can be learned from behavioural performance. The task involves a trade-off between the need for stochasticity, to allow strategies to be discriminated, and a need for determinism, so that it is worth subjects' investment of effort to exploit the contingencies optimally. We show through simulation that under certain conditions model-free strategies can masquerade as being model-based. We first show that seemingly innocuous modifications to the task structure can induce correlations between action values at the start of the trial and the subsequent trial events in such a way that analysis based on comparing successive trials can lead to erroneous conclusions. We confirm the power of a suggested correction to the analysis that can alleviate this problem. We then consider model-free reinforcement learning strategies that exploit correlations between where rewards are obtained and which actions have high expected value. These generate behaviour that appears model-based under these, and also more sophisticated, analyses. Exploiting the full potential of the two-step task as a tool for behavioural neuroscience requires an understanding of these issues.

  16. Multiple stage miniature stepping motor

    International Nuclear Information System (INIS)

    Niven, W.A.; Shikany, S.D.; Shira, M.L.

    1981-01-01

    A stepping motor comprising a plurality of stages which may be selectively activated to effect stepping movement of the motor, and which are mounted along a common rotor shaft to achieve considerable reduction in motor size and minimum diameter, whereby sequential activation of the stages results in successive rotor steps with direction being determined by the particular activating sequence followed

  17. Can Reduced-Step Polishers Be as Effective as Multiple-Step Polishers in Enhancing Surface Smoothness?

    Science.gov (United States)

    Kemaloglu, Hande; Karacolak, Gamze; Turkun, L Sebnem

    2017-02-01

    The aim of this study was to evaluate the effects of various finishing and polishing systems on the final surface roughness of a resin composite. Hypotheses tested were: (1) reduced-step polishing systems are as effective as multiple-step systems on reducing the surface roughness of a resin composite and (2) the number of application steps in an F/P system has no effect on reducing surface roughness. Ninety discs of a nano-hybrid resin composite were fabricated and divided into nine groups (n = 10). Except the control, all of the specimens were roughened prior to be polished by: Enamel Plus Shiny, Venus Supra, One-gloss, Sof-Lex Wheels, Super-Snap, Enhance/PoGo, Clearfil Twist Dia, and rubber cups. The surface roughness was measured and the surfaces were examined under scanning electron microscope. Results were analyzed with analysis of variance and Holm-Sidak's multiple comparisons test (p One-gloss, Enamel Plus Shiny, and Venus Supra groups. (1) The number of application steps has no effect on the performance of F/P systems. (2) Reduced-step polishers used after a finisher can be preferable to multiple-step systems when used on nanohybrid resin composites. (3) The effect of F/P systems on surface roughness seems to be material-dependent rather than instrument- or system-dependent. Reduced-step systems used after a prepolisher can be an acceptable alternative to multiple-step systems on enhancing the surface smoothness of a nanohybrid composite; however, their effectiveness depends on the materials' properties. (J Esthet Restor Dent 29:31-40, 2017). © 2016 Wiley Periodicals, Inc.

  18. Potential Next Steps for the New Orleans City Council Energy Efficiency Resolution

    Energy Technology Data Exchange (ETDEWEB)

    Doris, E.

    2011-09-01

    This document is adapted from an actual February 2008 deliverable memo and report delivered by the National Renewable Energy Laboratory (NREL) to the City Council of New Orleans, the office of the Mayor of New Orleans, the Chairperson of the Citizen Stakeholders Group (New Orleans Energy Task Force) and the Department of Energy Project Officer in February of 2008. In January 2008, the New Orleans Utility Committee requested review, commentary, and suggestions for Utility Committee next steps related to the Energy Efficiency Resolution (the Resolution) passed by the City Council in December 2007. The suggestions are reprinted here as: (1) An illustration of opportunities for other local governments for the development and implementation of effective energy efficiency ordinances and resolutions; and (2) An example of the type of policy technical assistance that DOE/NREL provides to communities. For more information on the strategy for delivering assistance, please see: www.nrel.gov/docs/fy11osti/48689.pdf. Based on experience in other communities and energy efficiency policies and programs, NREL found the Resolution to be a solid framework for increasing the responsible use of energy efficiency and reaping the associated economic and environmental benefits in the city of New Orleans. The remainder of this document provides the requested suggestions for next steps in implementing the word and spirit of the resolution. These suggestions integrate the extensive work of other entities, including the New Orleans Mayor's office, the New Orleans Energy Advisory Committee, the Energy Efficiency Initiative, and the U.S. Environmental Protection Agency's National Action Plan for Energy Efficiency. In general, three actions were suggested for funding mechanisms, two for near-term successes, and two for longer-term success.

  19. Step-grandparenthood in the United States.

    Science.gov (United States)

    Yahirun, Jenjira J; Park, Sung S; Seltzer, Judith A

    2018-01-18

    This study provides new information about the demography of step-grandparenthood in the United States. Specifically, we examine the prevalence of step-grandparenthood across birth cohorts and for socioeconomic and racial/ethnic groups. We also examine lifetime exposure to the step-grandparent role. Using data from the Panel Study of Income Dynamics and the Health and Retirement Study, we use percentages to provide first estimates of step-grandparenthood and to describe demographic and socioeconomic variation in who is a step-grandparent. We use life tables to estimate the exposure to step-grandparenthood. The share of step-grandparents is increasing across birth cohorts. However, individuals without a college education and non-Whites are more likely to become step-grandparents. Exposure to the step-grandparent role accounts for approximately 15% of total grandparent years at age 65 for women and men. A growing body of research finds that grandparents are increasingly instrumental in the lives of younger generations. However, the majority of this work assumes that these ties are biological, with little attention paid to the role of family complexity across three generations. Understanding the demographics of step-grandparenthood sheds light on the family experiences of an overlooked, but growing segment of the older adult population in the United States. © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  20. Our actions in my mind: Motor imagery of joint action

    DEFF Research Database (Denmark)

    Vesper, Cordula; Knoblich, Günther; Sebanz, Natalie

    2014-01-01

    How do people imagine performing actions together? The present study investigated motor imagery of joint actions that requires integrating one's own and another's part of an action. In two experiments, individual participants imagined jumping alone or jointly next to an imagined partner. The joint...... condition required coordinating one's own imagined actions with an imagined partner's actions to synchronize landing times. We investigated whether the timing of participants' own imagined jumps would reflect the difference in jump distance to their imagined partner's jumps. The results showed...... of joint jumping. These findings link research on motor imagery and joint action, demonstrating that individuals are able to integrate simulations of different parts of a joint action....

  1. The Throw-and-Catch Model of Human Gait: Evidence from Coupling of Pre-Step Postural Activity and Step Location

    Science.gov (United States)

    Bancroft, Matthew J.; Day, Brian L.

    2016-01-01

    Postural activity normally precedes the lift of a foot from the ground when taking a step, but its function is unclear. The throw-and-catch hypothesis of human gait proposes that the pre-step activity is organized to generate momentum for the body to fall ballistically along a specific trajectory during the step. The trajectory is appropriate for the stepping foot to land at its intended location while at the same time being optimally placed to catch the body and regain balance. The hypothesis therefore predicts a strong coupling between the pre-step activity and step location. Here we examine this coupling when stepping to visually-presented targets at different locations. Ten healthy, young subjects were instructed to step as accurately as possible onto targets placed in five locations that required either different step directions or different step lengths. In 75% of trials, the target location remained constant throughout the step. In the remaining 25% of trials, the intended step location was changed by making the target jump to a new location 96 ms ± 43 ms after initiation of the pre-step activity, long before foot lift. As predicted by the throw-and-catch hypothesis, when the target location remained constant, the pre-step activity led to body momentum at foot lift that was coupled to the intended step location. When the target location jumped, the pre-step activity was adjusted (median latency 223 ms) and prolonged (on average by 69 ms), which altered the body’s momentum at foot lift according to where the target had moved. We conclude that whenever possible the coupling between the pre-step activity and the step location is maintained. This provides further support for the throw-and-catch hypothesis of human gait. PMID:28066208

  2. The Throw-and-Catch Model of Human Gait: Evidence from Coupling of Pre-Step Postural Activity and Step Location.

    Science.gov (United States)

    Bancroft, Matthew J; Day, Brian L

    2016-01-01

    Postural activity normally precedes the lift of a foot from the ground when taking a step, but its function is unclear. The throw-and-catch hypothesis of human gait proposes that the pre-step activity is organized to generate momentum for the body to fall ballistically along a specific trajectory during the step. The trajectory is appropriate for the stepping foot to land at its intended location while at the same time being optimally placed to catch the body and regain balance. The hypothesis therefore predicts a strong coupling between the pre-step activity and step location. Here we examine this coupling when stepping to visually-presented targets at different locations. Ten healthy, young subjects were instructed to step as accurately as possible onto targets placed in five locations that required either different step directions or different step lengths. In 75% of trials, the target location remained constant throughout the step. In the remaining 25% of trials, the intended step location was changed by making the target jump to a new location 96 ms ± 43 ms after initiation of the pre-step activity, long before foot lift. As predicted by the throw-and-catch hypothesis, when the target location remained constant, the pre-step activity led to body momentum at foot lift that was coupled to the intended step location. When the target location jumped, the pre-step activity was adjusted (median latency 223 ms) and prolonged (on average by 69 ms), which altered the body's momentum at foot lift according to where the target had moved. We conclude that whenever possible the coupling between the pre-step activity and the step location is maintained. This provides further support for the throw-and-catch hypothesis of human gait.

  3. The effects of age and step length on joint kinematics and kinetics of large out-and-back steps.

    Science.gov (United States)

    Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B

    2008-06-01

    Maximum step length (MSL) is a clinical test that has been shown to correlate with age, various measures of fall risk, and knee and hip joint extension speed, strength, and power capacities, but little is known about the kinematics and kinetics of the large out-and-back step utilized. Body motions and ground reaction forces were recorded for 11 unimpaired younger and 10 older women while attaining maximum step length. Joint kinematics and kinetics were calculated using inverse dynamics. The effects of age group and step length on the biomechanics of these large out-and-back steps were determined. Maximum step length was 40% greater in the younger than in the older women (P<0.0001). Peak knee and hip, but not ankle, angle, velocity, moment, and power were generally greater for younger women and longer steps. After controlling for age group, step length generally explained significant additional variance in hip and torso kinematics and kinetics (incremental R2=0.09-0.37). The young reached their peak knee extension moment immediately after landing of the step out, while the old reached their peak knee extension moment just before the return step liftoff (P=0.03). Maximum step length is strongly associated with hip kinematics and kinetics. Delays in peak knee extension moment that appear to be unrelated to step length, may indicate a reduced ability of older women to rapidly apply force to the ground with the stepping leg and thus arrest the momentum of a fall.

  4. Biomechanical influences on balance recovery by stepping.

    Science.gov (United States)

    Hsiao, E T; Robinovitch, S N

    1999-10-01

    Stepping represents a common means for balance recovery after a perturbation to upright posture. Yet little is known regarding the biomechanical factors which determine whether a step succeeds in preventing a fall. In the present study, we developed a simple pendulum-spring model of balance recovery by stepping, and used this to assess how step length and step contact time influence the effort (leg contact force) and feasibility of balance recovery by stepping. We then compared model predictions of step characteristics which minimize leg contact force to experimentally observed values over a range of perturbation strengths. At all perturbation levels, experimentally observed step execution times were higher than optimal, and step lengths were smaller than optimal. However, the predicted increase in leg contact force associated with these deviations was substantial only for large perturbations. Furthermore, increases in the strength of the perturbation caused subjects to take larger, quicker steps, which reduced their predicted leg contact force. We interpret these data to reflect young subjects' desire to minimize recovery effort, subject to neuromuscular constraints on step execution time and step length. Finally, our model predicts that successful balance recovery by stepping is governed by a coupling between step length, step execution time, and leg strength, so that the feasibility of balance recovery decreases unless declines in one capacity are offset by enhancements in the others. This suggests that one's risk for falls may be affected more by small but diffuse neuromuscular impairments than by larger impairment in a single motor capacity.

  5. Learning, attentional control, and action video games.

    Science.gov (United States)

    Green, C S; Bavelier, D

    2012-03-20

    While humans have an incredible capacity to acquire new skills and alter their behavior as a result of experience, enhancements in performance are typically narrowly restricted to the parameters of the training environment, with little evidence of generalization to different, even seemingly highly related, tasks. Such specificity is a major obstacle for the development of many real-world training or rehabilitation paradigms, which necessarily seek to promote more general learning. In contrast to these typical findings, research over the past decade has shown that training on 'action video games' produces learning that transfers well beyond the training task. This has led to substantial interest among those interested in rehabilitation, for instance, after stroke or to treat amblyopia, or training for various precision-demanding jobs, for instance, endoscopic surgery or piloting unmanned aerial drones. Although the predominant focus of the field has been on outlining the breadth of possible action-game-related enhancements, recent work has concentrated on uncovering the mechanisms that underlie these changes, an important first step towards the goal of designing and using video games for more definite purposes. Game playing may not convey an immediate advantage on new tasks (increased performance from the very first trial), but rather the true effect of action video game playing may be to enhance the ability to learn new tasks. Such a mechanism may serve as a signature of training regimens that are likely to produce transfer of learning. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Towards a common framework of grounded action cognition: Relating motor control, perception and cognition.

    Science.gov (United States)

    Gentsch, Antje; Weber, Arne; Synofzik, Matthis; Vosgerau, Gottfried; Schütz-Bosbach, Simone

    2016-01-01

    The relation between motor control and action cognition - including action-related thoughts and action-related perception - has been subject to controversial discussions in the last three decades. During these decades, cognitive neuroscience has been increasingly confronted with a huge variety of different accounts trying to understand and explain the relation between these systems, their interdependencies and the mediating mechanisms by establishing notions such as "internal models", "simulation" or "shared representation". These accounts, however, include a large array of partly overlapping, partly contradictory theories using similar terms for different mechanisms and different terms for similar mechanisms. In the absence of a systematic work-up and comparison, this array of accounts and theories leads to confusion in the field, duplication of experimental work, and unconnected parallelism of theory formation within and between different disciplines. Here we provide a systematic comparison of current models and prospective theories that deal with the relation between cognition, perception and motor control mechanisms. In a second step, we propose "grounded action cognition" as a comprehensive metatheoretical framework which defines different hypothetical possibilities of the relations between these domains, offers systematic insights into current models and theories and last but not least may help to increase comparability of empirical research in the domain of action and action cognition. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Stepwise hydrogeological modeling and groundwater flow analysis on site scale (Step 0 and Step 1)

    International Nuclear Information System (INIS)

    Ohyama, Takuya; Saegusa, Hiromitsu; Onoe, Hironori

    2005-05-01

    One of the main goals of the Mizunami Underground Research Laboratory Project is to establish comprehensive techniques for investigation, analysis, and assessment of the deep geological environment. To achieve this goal, a variety of investigations, analysis, and evaluations have been conducted using an iterative approach. In this study, hydrogeological modeling and ground water flow analyses have been carried out using the data from surface-based investigations at Step 0 and Step 1, in order to synthesize the investigation results, to evaluate the uncertainty of the hydrogeological model, and to specify items for further investigation. The results of this study are summarized as follows: 1) As the investigation progresses Step 0 to Step 1, the understanding of groundwater flow was enhanced from Step 0 to Step 1, and the hydrogeological model could be revised, 2) The importance of faults as major groundwater flow pathways was demonstrated, 3) Geological and hydrogeological characteristics of faults with orientation of NNW and NE were shown to be especially significant. The main item specified for further investigations is summarized as follows: geological and hydrogeological characteristics of NNW and NE trending faults are important. (author)

  8. Multi-step contrast sensitivity gauge

    Science.gov (United States)

    Quintana, Enrico C; Thompson, Kyle R; Moore, David G; Heister, Jack D; Poland, Richard W; Ellegood, John P; Hodges, George K; Prindville, James E

    2014-10-14

    An X-ray contrast sensitivity gauge is described herein. The contrast sensitivity gauge comprises a plurality of steps of varying thicknesses. Each step in the gauge includes a plurality of recesses of differing depths, wherein the depths are a function of the thickness of their respective step. An X-ray image of the gauge is analyzed to determine a contrast-to-noise ratio of a detector employed to generate the image.

  9. Felt Moral Obligation and the Moral Judgement-Moral Action Gap: Toward a Phenomenology of Moral Life

    Science.gov (United States)

    Williams, Richard N.; Gantt, Edwin E.

    2012-01-01

    The step-off point for this article is the problem of the "moral judgement-moral action gap" as found in contemporary literature of moral education and moral development. We argue that this gap, and the conceptual problems encountered by attempts to bridge it, reflects the effect of a different, deeper and more problematic conceptual gap: the…

  10. Step one within stepped care trauma-focused cognitive behavioral therapy for young children: a pilot study.

    Science.gov (United States)

    Salloum, Alison; Robst, John; Scheeringa, Michael S; Cohen, Judith A; Wang, Wei; Murphy, Tanya K; Tolin, David F; Storch, Eric A

    2014-02-01

    This pilot study explored the preliminary efficacy, parent acceptability and economic cost of delivering Step One within Stepped Care Trauma-Focused Cognitive Behavioral Therapy (SC-TF-CBT). Nine young children ages 3-6 years and their parents participated in SC-TF-CBT. Eighty-three percent (5/6) of the children who completed Step One treatment and 55.6 % (5/9) of the intent-to-treat sample responded to Step One. One case relapsed at post-assessment. Treatment gains were maintained at 3-month follow-up. Generally, parents found Step One to be acceptable and were satisfied with treatment. At 3-month follow-up, the cost per unit improvement for posttraumatic stress symptoms and severity ranged from $27.65 to $131.33 for the responders and from $36.12 to $208.11 for the intent-to-treat sample. Further research on stepped care for young children is warranted to examine if this approach is more efficient, accessible and cost-effective than traditional therapy.

  11. Step 2: Know Your Diabetes ABCs

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Type 2 Diabetes Step 2: Know Your Diabetes ABCs Past Issues / Fall ... 2 Diabetes" Articles Diabetes Is Serious But Manageable / Step 1: Learn About Diabetes / Step 2: Know Your ...

  12. Perfect 3-dimensional lattice actions for 4-dimensional quantum field theories at finite temperature

    International Nuclear Information System (INIS)

    Kerres, U.; Mack, G.; Palma, G.

    1994-12-01

    We propose a two-step procedure to study the order of phase transitions at finite temperature in electroweak theory and in simplified models thereof. In a first step a coarse grained free energy is computed by perturbative methods. It is obtained in the form of a 3-dimensional perfect lattice action by a block spin transformation. It has finite temperature dependent coefficients. In this way the UV-problem and the infrared problem is separated in a clean way. In the second step the effective 3-dimensional lattice theory is treated in a nonperturbative way, either by the Feynman-Bololiubov method (solution of a gap equation), by real space renormalization group methods, or by computer simulations. In this paper we outline the principles for φ 4 -theory and scalar electrodynamics. The Balaban-Jaffe block spin transformation for the gauge field is used. It is known how to extend this transformation to the nonabelian case, but this will not be discussed here. (orig.)

  13. The micro-step motor controller

    International Nuclear Information System (INIS)

    Hong, Kwang Pyo; Lee, Chang Hee; Moon, Myung Kook; Choi, Bung Hun; Choi, Young Hyun; Cheon, Jong Gu

    2004-11-01

    The developed micro-step motor controller can handle 4 axes stepping motor drivers simultaneously and provide high power bipolar driving mechanism with constant current mode. It can be easily controlled by manual key functions and the motor driving status is displayed by the front panel VFD. Due to the development of several kinds of communication and driving protocol, PC can operate even several micro-step motor controllers at once by multi-drop connection

  14. The construction of geological model using an iterative approach (Step 1 and Step 2)

    International Nuclear Information System (INIS)

    Matsuoka, Toshiyuki; Kumazaki, Naoki; Saegusa, Hiromitsu; Sasaki, Keiichi; Endo, Yoshinobu; Amano, Kenji

    2005-03-01

    One of the main goals of the Mizunami Underground Research Laboratory (MIU) Project is to establish appropriate methodologies for reliably investigating and assessing the deep subsurface. This report documents the results of geological modeling of Step 1 and Step 2 using the iterative investigation approach at the site-scale (several 100m to several km in area). For the Step 1 model, existing information (e.g. literature), and results from geological mapping and reflection seismic survey were used. For the Step 2 model, additional information obtained from the geological investigation using existing borehole and the shallow borehole investigation were incorporated. As a result of this study, geological elements that should be represented in the model were defined, and several major faults with trends of NNW, EW and NE trend were identified (or inferred) in the vicinity of the MIU-site. (author)

  15. Small steps to health: building sustainable partnerships in pediatric obesity care.

    Science.gov (United States)

    Pomietto, Mo; Docter, Alicia Dixon; Van Borkulo, Nicole; Alfonsi, Lorrie; Krieger, James; Liu, Lenna L

    2009-06-01

    Given the prevalence of childhood obesity and the limited support for preventing and managing obesity in primary care settings, the Seattle Children's Hospital's Children's Obesity Action Team has partnered with Steps to Health King County to develop a pediatric obesity quality-improvement project. Primary care clinics joined year-long quality-improvement collaboratives to integrate obesity prevention and management into the clinic setting by using the chronic-disease model. Sustainability was enhanced through integration at multiple levels by emphasizing small, consistent behavior changes and self-regulation of eating/feeding practices with children, teenagers, and families; building local community partnerships; and encouraging broader advocacy and policy change. Cultural competency and attention to disparities were integrated into quality-improvement efforts. . Participating clinics were able to increase BMI measurement and weight classification; integrate management of overweight/obese children and family and self-management support; and grow community collaborations. Over the course of 4 years, this project grew from a local effort involving 3 clinics to a statewide program recently adopted by the Washington State Department of Health. This model can be used by other states/regions to develop pediatric obesity quality-improvement programs to support the assessment, prevention, and management of childhood obesity. Furthermore, these health care efforts can be integrated into broader community-wide childhood-obesity action plans.

  16. A Meta-Analysis of Local Climate Change Adaptation Actions ...

    Science.gov (United States)

    Local governments are beginning to take steps to address the consequences of climate change, such as sea level rise and heat events. However, we do not have a clear understanding of what local governments are doing -- the extent to which they expect climate change to affect their community, the types of actions they have in place to address climate change, and the resources at their disposal for implementation. Several studies have been conducted by academics, non-governmental organizations, and public agencies to assess the status of local climate change adaptation. This project collates the findings from dozens of such studies to conduct a meta-analysis of local climate change adaptation actions. The studies will be characterized along several dimensions, including (a) methods used, (b) timing and geographic scope, (c) topics covered, (d) types of adaptation actions identified, (e) implementation status, and (f) public engagement and environmental justice dimensions considered. The poster presents the project's rationale and approach and some illustrative findings from early analyses. [Note: The document being reviewed is an abstract in which a poster is being proposed. The poster will enter clearance if the abstract is accepted] The purpose of this poster is to present the research framework and approaches I am developing for my ORISE postdoctoral project, and to get feedback on early analyses.

  17. Networks for prevention of violence: from utopia to action

    Directory of Open Access Journals (Sweden)

    Kathie Njaine

    2006-06-01

    Full Text Available This article aims to discuss the experience of networks for the protection of people exposed to situations of violence or prevention networks. It is based on the concept created by Castells, who defines the information age. This study is part of the investigation "Successful experiences in the prevention of violence", carried out by the Latin-American Center for Studies on Violence Jorge Careli/ENSP-IFF/Fiocruz, in cooperation with the Secretariat for Health Survey of the Ministry of Health. The article analyzes the possibilities and limitations in the construction of networks for the prevention of violence, seeking to understand the sense of actions and movements carried out in networks. The method we used is a case study of two network initiatives in the Southern region of the country. In terms of results, in face of the difficulties of working in networks, we found it to be necessary: to break with sectorial and vertical actions; to promote constant communication and interchange of information; to permanently train the professionals and persons involved in the network, incorporating them into the protective and preventive actions; and to promote the participation of wide social sectors. In conclusion, one can affirm that the construction of a protection network involves complex steps, looking to the same problem with new eyes and a new vision for planting solutions.

  18. Integrated Marketing for Colleges, Universities, and Schools: A Step-by-Step Planning Guide.

    Science.gov (United States)

    Sevier, Robert A.

    This book offers a step-by-step approach to marketing for educational institutions, especially colleges and universities. The book is organized into three broad sections. Section 1 makes the case for marketing in six chapters which address: (1) challenges which are or will affect colleges and universities; (2) the role of institutional mission,…

  19. Action recognition in depth video from RGB perspective: A knowledge transfer manner

    Science.gov (United States)

    Chen, Jun; Xiao, Yang; Cao, Zhiguo; Fang, Zhiwen

    2018-03-01

    Different video modal for human action recognition has becoming a highly promising trend in the video analysis. In this paper, we propose a method for human action recognition from RGB video to Depth video using domain adaptation, where we use learned feature from RGB videos to do action recognition for depth videos. More specifically, we make three steps for solving this problem in this paper. First, different from image, video is more complex as it has both spatial and temporal information, in order to better encode this information, dynamic image method is used to represent each RGB or Depth video to one image, based on this, most methods for extracting feature in image can be used in video. Secondly, as video can be represented as image, so standard CNN model can be used for training and testing for videos, beside, CNN model can be also used for feature extracting as its powerful feature expressing ability. Thirdly, as RGB videos and Depth videos are belong to two different domains, in order to make two different feature domains has more similarity, domain adaptation is firstly used for solving this problem between RGB and Depth video, based on this, the learned feature from RGB video model can be directly used for Depth video classification. We evaluate the proposed method on one complex RGB-D action dataset (NTU RGB-D), and our method can have more than 2% accuracy improvement using domain adaptation from RGB to Depth action recognition.

  20. The time between intention and action affect the experience of action

    Directory of Open Access Journals (Sweden)

    Mikkel C. Vinding

    2015-06-01

    Full Text Available We present a study investigating how the delay between the intention to act and the following action, influenced the experience of action. In experiments investigating sense of agency and experience of action, the contrast is most often between voluntary and involuntary actions. It is rarely asked whether different types of intentions influence the experience of action differently. To investigate this we distinguished between proximal intentions (i.e. intentions for immediate actions and delayed intentions (i.e. intentions with a temporal delay between intention and action. The distinction was implemented in an intentional binding paradigm, by varying the delay between the time where participants formed the intention to act and the time at which they performed the action. The results showed that delayed intentions were followed by a stronger binding effect for the tone following the action compared to proximal intentions. The actions were reported to have occurred earlier for delayed intentions than for proximal intentions. This effect was independent of the binding effect usually found in intentional binding experiments. This suggests that two perceptual shifts occurred in the contrast between delayed intentions and proximal intentions: The first being the binding effect, the second a general shift in the perceived time of action. Neither the stronger binding effect for tone, nor the earlier reports of action, differed across delays for delayed intentions. The results imply that delayed intentions and proximal intentions have a different impact on the experience of action.

  1. DAPs: Deep Action Proposals for Action Understanding

    KAUST Repository

    Escorcia, Victor; Caba Heilbron, Fabian; Niebles, Juan Carlos; Ghanem, Bernard

    2016-01-01

    action proposals from long videos. We show how to take advantage of the vast capacity of deep learning models and memory cells to retrieve from untrimmed videos temporal segments, which are likely to contain actions. A comprehensive evaluation indicates

  2. Step-wise stimulated martensitic transformations

    International Nuclear Information System (INIS)

    Airoldi, G.; Riva, G.

    1991-01-01

    NiTi alloys, widely known both for their shape memory properties and for unusual pseudoelastic behaviour, are now on the forefront attention for step-wise induced memory processes, thermal or stress stimulated. Literature results related to step-wise stimulated martensite (direct transformation) are examined and contrasted with step-wise thermal stimulated parent phase (reverse transformation). Hypothesis are given to explain the key characters of both transformations, a thermodynamic model from first principles being till now lacking

  3. Microprocessor-based stepping motor driver

    International Nuclear Information System (INIS)

    Halbig, J.K.; Klosterbuer, S.F.

    1979-09-01

    The Pion Generation for Medical Irradiations (PIGMI) program at the Los Alamos Scientific Laboratory requires a versatile stepping motor driver to do beam diagnostic measurements. A driver controlled by a microprocessor that can move eight stepping motors simultaneously was designed. The driver can monitor and respond to clockwise- and counterclockwise-limit switches, and it can monitor a 0- to 10-V dc position signal. The software controls start and stop ramping and maximum stepping rates. 2 figures, 1 table

  4. Commonwealth of the Northern Mariana Islands Energy Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    Conrad, M. D.; Ness, J. E.

    2013-07-01

    This document describes the three near-term energy strategies selected by the CNMI Energy Task Force during action planning workshops conducted in March 2013, and outlines the steps being taken to implement those strategies. The three energy strategies selected by the task force are (1) designing a demand-side management program focusing on utility, residential and commercial sectors, (2) developing an outreach and education plan focused on energy conservation in government agencies and businesses, including workplace rules, and (3) exploring waste-to-energy options. The task force also discussed several other medium- and long-term energy strategies that could be explored at a future date.

  5. Comparison of single-step and two-step purified coagulants from Moringa oleifera seed for turbidity and DOC removal.

    Science.gov (United States)

    Sánchez-Martín, J; Ghebremichael, K; Beltrán-Heredia, J

    2010-08-01

    The coagulant proteins from Moringa oleifera purified with single-step and two-step ion-exchange processes were used for the coagulation of surface water from Meuse river in The Netherlands. The performances of the two purified coagulants and the crude extract were assessed in terms of turbidity and DOC removal. The results indicated that the optimum dosage of the single-step purified coagulant was more than two times higher compared to the two-step purified coagulant in terms of turbidity removal. And the residual DOC in the two-step purified coagulant was lower than in single-step purified coagulant or crude extract. (c) 2010 Elsevier Ltd. All rights reserved.

  6. Research-informed strategies to address educational challenges in a digitally networked world: the EDUsummIT 2013 action agenda

    NARCIS (Netherlands)

    Voogt, J.; Knezek, G.; Searson, M.; Lai, K.W.; Gibson, D.; Khaddage, F.; Mishra, P.; Laferriere, T.; Resta, P.; Fisser, P.; Albion, P.; Searson, M.; Ochoa, M.

    2014-01-01

    EduSummIT is a global community of policy-makers, researchers, and educators working together to move education into the digital age. EDUsummIT 2013 took place in Washington DC and resulted in an action agenda for researchers, policy makers and educators to take concrete steps to move education in

  7. Dynamic balance and stepping versus tai chi training to improve balance and stepping in at-risk older adults.

    Science.gov (United States)

    Nnodim, Joseph O; Strasburg, Debra; Nabozny, Martina; Nyquist, Linda; Galecki, Andrzej; Chen, Shu; Alexander, Neil B

    2006-12-01

    To compare the effect of two 10-week balance training programs, Combined Balance and Step Training (CBST) versus tai chi (TC), on balance and stepping measures. Prospective intervention trial. Local senior centers and congregate housing facilities. Aged 65 and older with at least mild impairment in the ability to perform unipedal stance and tandem walk. Participants were allocated to TC (n = 107, mean age 78) or CBST, an intervention focused on improving dynamic balance and stepping (n = 106, mean age 78). At baseline and 10 weeks, participants were tested in their static balance (Unipedal Stance and Tandem Stance (TS)), stepping (Maximum Step Length, Rapid Step Test), and Timed Up and Go (TUG). Performance improved more with CBST than TC, ranging from 5% to 10% for the stepping tests (Maximum Step Length and Rapid Step Test) and 9% for TUG. The improvement in TUG represented an improvement of more than 1 second. Greater improvements were also seen in static balance ability (in TS) with CBST than TC. Of the two training programs, in which variants of each program have been proven to reduce falls, CBST results in modest improvements in balance, stepping, and functional mobility versus TC over a 10-week period. Future research should include a prospective comparison of fall rates in response to these two balance training programs.

  8. Peyton’s four-step approach: differential effects of single instructional steps on procedural and memory performance – a clarification study

    Directory of Open Access Journals (Sweden)

    Krautter M

    2015-05-01

    Full Text Available Markus Krautter,1 Ronja Dittrich,2 Annette Safi,2 Justine Krautter,1 Imad Maatouk,2 Andreas Moeltner,2 Wolfgang Herzog,2 Christoph Nikendei2 1Department of Nephrology, 2Department of General Internal and Psychosomatic Medicine, University of Heidelberg Medical Hospital, Heidelberg, Germany Background: Although Peyton’s four-step approach is a widely used method for skills-lab training in undergraduate medical education and has been shown to be more effective than standard instruction, it is unclear whether its superiority can be attributed to a specific single step. Purpose: We conducted a randomized controlled trial to investigate the differential learning outcomes of the separate steps of Peyton’s four-step approach. Methods: Volunteer medical students were randomly assigned to four different groups. Step-1 group received Peyton’s Step 1, Step-2 group received Peyton’s Steps 1 and 2, Step-3 group received Peyton’s Steps 1, 2, and 3, and Step-3mod group received Peyton’s Steps 1 and 2, followed by a repetition of Step 2. Following the training, the first independent performance of a central venous catheter (CVC insertion using a manikin was video-recorded and scored by independent video assessors using binary checklists. The day after the training, memory performance during delayed recall was assessed with an incidental free recall test. Results: A total of 97 participants agreed to participate in the trial. There were no statistically significant group differences with regard to age, sex, completed education in a medical profession, completed medical clerkships, preliminary memory tests, or self-efficacy ratings. Regarding checklist ratings, Step-2 group showed a superior first independent performance of CVC placement compared to Step-1 group (P<0.001, and Step-3 group showed a superior performance to Step-2 group (P<0.009, while Step-2 group and Step-3mod group did not differ (P=0.055. The findings were similar in the incidental

  9. 7 CFR 65.230 - Production step.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Production step. 65.230 Section 65.230 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., PEANUTS, AND GINSENG General Provisions Definitions § 65.230 Production step. Production step means, in...

  10. Two-step chemical decontamination technology

    International Nuclear Information System (INIS)

    Rankin, W.N.

    1992-01-01

    An improved two-step chemical decontamination technique was recently developed at INEL. This memorandum documents the addition of this technology to the SRTC arsenal of decontamination technology. A two-step process using NAOH, KMnO 4 followed by HNO 3 was used for cleaning doorstops (small casks) in the SRTC High Level Caves in 1967. Subsequently, more aggressive chemical techniques have been found to be much more effective for our applications. No further work on two-step technology is planned

  11. Electric-current-induced step bunching on Si(111)

    International Nuclear Information System (INIS)

    Homma, Yoshikazu; Aizawa, Noriyuki

    2000-01-01

    We experimentally investigated step bunching induced by direct current on vicinal Si(111)'1x1' surfaces using scanning electron microscopy and atomic force microscopy. The scaling relation between the average step spacing l b and the number of steps N in a bunch, l b ∼N -α , was determined for four step-bunching temperature regimes above the 7x7-'1x1' transition temperature. The step-bunching rate and scaling exponent differ between neighboring step-bunching regimes. The exponent α is 0.7 for the two regimes where the step-down current induces step bunching (860-960 and 1210-1300 deg. C), and 0.6 for the two regimes where the step-up current induces step bunching (1060-1190 and >1320 deg. C). The number of single steps on terraces also differs in each of the four temperature regimes. For temperatures higher than 1280 deg. C, the prefactor of the scaling relation increases, indicating an increase in step-step repulsion. The scaling exponents obtained agree reasonably well with those predicted by theoretical models. However, they give unrealistic values for the effective charges of adatoms for step-up-current-induced step bunching when the 'transparent' step model is used

  12. Applying a health action model to predict and improve healthy behaviors in coal miners.

    Science.gov (United States)

    Vahedian-Shahroodi, Mohammad; Tehrani, Hadi; Mohammadi, Faeze; Gholian-Aval, Mahdi; Peyman, Nooshin

    2018-05-01

    One of the most important ways to prevent work-related diseases in occupations such as mining is to promote healthy behaviors among miners. This study aimed to predict and promote healthy behaviors among coal miners by using a health action model (HAM). The study was conducted on 200 coal miners in Iran in two steps. In the first step, a descriptive study was implemented to determine predictive constructs and effectiveness of HAM on behavioral intention. The second step involved a quasi-experimental study to determine the effect of an HAM-based education intervention. This intervention was implemented by the researcher and the head of the safety unit based on the predictive construct specified in the first step over 12 sessions of 60 min. The data was collected using an HAM questionnaire and a checklist of healthy behavior. The results of the first step of the study showed that attitude, belief, and normative constructs were meaningful predictors of behavioral intention. Also, the results of the second step revealed that the mean score of attitude and behavioral intention increased significantly after conducting the intervention in the experimental group, while the mean score of these constructs decreased significantly in the control group. The findings of this study showed that HAM-based educational intervention could improve the healthy behaviors of mine workers. Therefore, it is recommended to extend the application of this model to other working groups to improve healthy behaviors.

  13. Steps in Researching the Music in Therapy

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2007-01-01

    The chapter introduces a generic flowchart + step-by-step guide for microanalysis of music (compositions and improvisations) in music therapy.......The chapter introduces a generic flowchart + step-by-step guide for microanalysis of music (compositions and improvisations) in music therapy....

  14. Hybrid Action Systems

    DEFF Research Database (Denmark)

    Ronkko, Mauno; Ravn, Anders P.

    1997-01-01

    a differential action, which allows differential equations as primitive actions. The extension allows us to model hybrid systems with both continuous and discrete behaviour. The main result of this paper is an extension of such a hybrid action system with parallel composition. The extension does not change...... the original meaning of the parallel composition, and therefore also the ordinary action systems can be composed in parallel with the hybrid action systems....

  15. Thermodynamic approach and comparison of two-step and single step DME (dimethyl ether) syntheses with carbon dioxide utilization

    International Nuclear Information System (INIS)

    Chen, Wei-Hsin; Hsu, Chih-Liang; Wang, Xiao-Dong

    2016-01-01

    DME (Dimethyl ether) synthesis from syngas with CO_2 utilization through two-step and single step processes is analyzed thermodynamically. The influences of reaction temperature, H_2/CO molar ratio, and CO_2/CO molar ratio on CO and CO_2 conversions, DME selectivity and yield, and thermal behavior are evaluated. Particular attention is paid to the comparison of the performance of DME synthesis between the two different methods. In the two-step method, the addition of CO_2 suppresses the CO conversion during methanol synthesis. An increase in CO_2/CO ratio decreases the CO_2 conversion (negative effect), but increases the total consumption amount of CO_2 (positive effect). At a given reaction temperature with H_2/CO = 4, the maximum DME yield develops at CO_2/CO = 1. In the single step method, over 98% of CO can be converted and the DME yield can be as high as 0.52 mol (mol CO)"−"1 at CO_2/CO = 2. The comparison of the single step and two-step processes indicates that the maximum CO conversion, DME selectivity, and DME yield in the former are higher than those in the latter, whereas an opposite result in the maximum CO_2 conversion is observed. These results reveal that the single step process has lower thermodynamic limitation and is a better option for DME synthesis. From CO_2 utilization point of view, the operation with low temperature, high H_2/CO ratio, and low CO_2/CO ratio results in higher CO_2 conversion, irrespective of two-step or single step DME synthesis. - Highlights: • DME (Dimethyl ether) synthesis with CO_2 utilization is analyzed thermodynamically. • Single step and two-step DME syntheses are studied and compared with each other. • CO_2 addition suppresses CO conversion in MeOH synthesis but increases MeOH yield. • The performance of the single step DME synthesis is better than that of the two-step one. • Increase CO_2/CO ratio decreases CO_2 conversion but increases CO_2 consumption amount.

  16. Climate Action Team

    Science.gov (United States)

    Science Partnerships Contact Us Climate Action Team & Climate Action Initiative The Climate Action programs and the state's Climate Adaptation Strategy. The CAT members are state agency secretaries and the . See CAT reports Climate Action Team Pages CAT Home Members Working Groups Reports Back to Top

  17. Step 1: Learn about Diabetes

    Science.gov (United States)

    ... please turn JavaScript on. Feature: Type 2 Diabetes Step 1: Learn About Diabetes Past Issues / Fall 2014 ... the whole family healthy! Here are four key steps to help you control your diabetes and live ...

  18. Stabilization of a three-dimensional limit cycle walking model through step-to-step ankle control.

    Science.gov (United States)

    Kim, Myunghee; Collins, Steven H

    2013-06-01

    Unilateral, below-knee amputation is associated with an increased risk of falls, which may be partially related to a loss of active ankle control. If ankle control can contribute significantly to maintaining balance, even in the presence of active foot placement, this might provide an opportunity to improve balance using robotic ankle-foot prostheses. We investigated ankle- and hip-based walking stabilization methods in a three-dimensional model of human gait that included ankle plantarflexion, ankle inversion-eversion, hip flexion-extension, and hip ad/abduction. We generated discrete feedback control laws (linear quadratic regulators) that altered nominal actuation parameters once per step. We used ankle push-off, lateral ankle stiffness and damping, fore-aft foot placement, lateral foot placement, or all of these as control inputs. We modeled environmental disturbances as random, bounded, unexpected changes in floor height, and defined balance performance as the maximum allowable disturbance value for which the model walked 500 steps without falling. Nominal walking motions were unstable, but were stabilized by all of the step-to-step control laws we tested. Surprisingly, step-by-step modulation of ankle push-off alone led to better balance performance (3.2% leg length) than lateral foot placement (1.2% leg length) for these control laws. These results suggest that appropriate control of robotic ankle-foot prosthesis push-off could make balancing during walking easier for individuals with amputation.

  19. Protecting drinkable water: an analysis of action plans and stakeholders' networks

    Science.gov (United States)

    Gascuel-Odoux, Chantal; Menard, Marjorie

    2015-04-01

    Since WFD the policy for protecting drinkable water has been enhanced in France. This policy establish the main components and the different steps for protecting drinkable water, and ask for defining and implementing an action plan for each contributing catchment. Despite ambitious objectives, the local implementation is difficult. Firstly there is a high diversity of stakeholders involved with local authorities, which are mainly: water agencies, agricultural chambers and consultants, authorities at regional and departmental levels. Most of the local authorities do not feel qualified enough for carrying out such a policy, as they are not really used to deal with technical and political issues related to agricultural diffuse pollutions. As a consequence assessed action plans are based on regulation and/or agri-environmental measures. More ambitious and complementary measures can be included, but without any support measure nor accurate objectives for their implementation. In the end, action plans reflect more a formal implementation of protection approaches than a search for efficiency by defining ambitious measures and the setting-up a consistent support scheme. The way stakeholders' networks mobilize knowledge have been analyzed based on ten case studies located in three different regions. Three local authorities profiles are defined: (1) the "passive" ones, not really convinced of the necessity to undertake actions against diffuse pollutions and/or having low level of knowledge to support local reflexion, that delegate project management; (2) the local authorities that support local protection approach but that, for different reasons, do not search for an effective action plan, and that only consider an improvement approach; (3) the local authorities that more rarely, aim at efficient actions, motivated by the urgent need of action for preserving threatened resources. According to these profiles, local authorities and their project coordinators will be looking

  20. Action Rules Mining

    CERN Document Server

    Dardzinska, Agnieszka

    2013-01-01

    We are surrounded by data, numerical, categorical and otherwise, which must to be analyzed and processed to convert it into information that instructs, answers or aids understanding and decision making. Data analysts in many disciplines such as business, education or medicine, are frequently asked to analyze new data sets which are often composed of numerous tables possessing different properties. They try to find completely new correlations between attributes and show new possibilities for users.   Action rules mining discusses some of data mining and knowledge discovery principles and then describe representative concepts, methods and algorithms connected with action. The author introduces the formal definition of action rule, notion of a simple association action rule and a representative action rule, the cost of association action rule, and gives a strategy how to construct simple association action rules of a lowest cost. A new approach for generating action rules from datasets with numerical attributes...

  1. Step patterns on vicinal reconstructed surfaces

    Science.gov (United States)

    Vilfan, Igor

    1996-04-01

    Step patterns on vicinal (2 × 1) reconstructed surfaces of noble metals Au(110) and Pt(110), miscut towards the (100) orientation, are investigated. The free energy of the reconstructed surface with a network of crossing opposite steps is calculated in the strong chirality regime when the steps cannot make overhangs. It is explained why the steps are not perpendicular to the direction of the miscut but form in equilibrium a network of crossing steps which make the surface to look like a fish skin. The network formation is the consequence of competition between the — predominantly elastic — energy loss and entropy gain. It is in agreement with recent scanning tunnelling microscopy observations on vicinal Au(110) and Pt(110) surfaces.

  2. Pendekatan Pelatihan On-Site dan Step by Step untuk Optimalisasi Fungsi Guru dalam Pembelajaran

    Directory of Open Access Journals (Sweden)

    Moch. Sholeh Y.A. Ichrom

    2016-02-01

    Full Text Available Remoteness of programme content from teachers' real work situation and unsuitability of approach employed were suspected as main reasons contributing to the failure of many inservise teacher training programmes. A step by step, onsite teacher training (SSOTT model was tried out in this experiment to study if the weakness of inservise programmes could be rectified. As it was tried out in relation with kindergarten mathemathics it was then called SSOTT-MTW (Step by Step Onsite Teacher Training-Methemathics Their Way model. Eighty four kindergartens were involved, in which 84 teachers and 877 pupils were recruited as experimental subjects. The teachers were devided into three group. One group was instructed by using One Period Teacher Training (OPOTT-MTW model, second group was trained with SSOTT-MTW model and the last group was given no training (NTT at all. Result of the experiment showed that the other groups. It was also shown that pupil and parents participation in teaching-learning activities also significantly improved.

  3. Effectiveness of a step-by-step oral recount before a practical simulation of fracture fixation.

    Science.gov (United States)

    Abagge, Marcelo; Uliana, Christiano Saliba; Fischer, Sergei Taggesell; Kojima, Kodi Edson

    2017-10-01

    To evaluate the effectiveness of a step-by-step oral recount by residents before the final execution of a practical exercise simulating a surgical fixation of a radial diaphyseal fracture. The study included 10 residents of orthopaedics and traumatology (four second- year and six first-year residents) divided into two groups with five residents each. All participants initially gathered in a room in which a video was presented demonstrating the practical exercise to be performed. One group (Group A) was referred directly to the practical exercise room. The other group (Group B) attended an extra session before the practical exercise, in which they were invited by instructors to recount all the steps that they would perform during the practical exercise. During this session, the instructors corrected the residents if any errors in the step-by-step recount were identified, and clarified questions from them. After this session, both Groups A and B gathered in a room in which they proceeded to the practical exercise, while being video recorded and evaluated using a 20-point checklist. Group A achieved a 57% accuracy, with results in this group ranging from 7 to 15 points out of a total of a possible 20 points. Group B achieved an 89% accuracy, with results in this group ranging from 15 to 20 points out of 20. An oral step-by-step recount by the residents before the final execution of a practical simulation exercise of surgical fixation of a diaphyseal radial fracture improved the technique and reduced the execution time of the exercise. © 2017 Elsevier Ltd. All rights reserved.

  4. Conceptual framework of public health surveillance and action and its application in health sector reform

    Directory of Open Access Journals (Sweden)

    Alemu Wondi

    2002-01-01

    Full Text Available Abstract Background Because both public health surveillance and action are crucial, the authors initiated meetings at regional and national levels to assess and reform surveillance and action systems. These meetings emphasized improved epidemic preparedness, epidemic response, and highlighted standardized assessment and reform. Methods To standardize assessments, the authors designed a conceptual framework for surveillance and action that categorized the framework into eight core and four support activities, measured with indicators. Results In application, country-level reformers measure both the presence and performance of the six core activities comprising public health surveillance (detection, registration, reporting, confirmation, analyses, and feedback and acute (epidemic-type and planned (management-type responses composing the two core activities of public health action. Four support activities – communications, supervision, training, and resource provision – enable these eight core processes. National, multiple systems can then be concurrently assessed at each level for effectiveness, technical efficiency, and cost. Conclusions This approach permits a cost analysis, highlights areas amenable to integration, and provides focused intervention. The final public health model becomes a district-focused, action-oriented integration of core and support activities with enhanced effectiveness, technical efficiency, and cost savings. This reform approach leads to sustained capacity development by an empowerment strategy defined as facilitated, process-oriented action steps transforming staff and the system.

  5. Impulsive action and motivation.

    Science.gov (United States)

    Frijda, Nico H

    2010-07-01

    This paper explores the way in which emotions are causal determinants of action. It argues that emotional events, as appraised by the individual, elicit changes in motive states (called states of action readiness), which in turn may (or may not) cause action. Actions can be elicited automatically, without prior intention (called impulsive actions), or intentionally. Impulsive actions reflect the simplest and biologically most general form in which emotions can cause action, since they require no reflection, no foresight, and no planning. Impulsive actions are determined conjointly by the nature of action readiness, the affordances perceived in the eliciting event as appraised, and the individual's action repertoire. Those actions from one's repertoire are performed that both match the perceived affordances and the aim of the state of action readiness. Copyright © 2010 Elsevier B.V. All rights reserved.

  6. 14 CFR 152.411 - Affirmative action steps.

    Science.gov (United States)

    2010-01-01

    ... contractor must encourage present minority and female employees to recruit other minorities and women. (7...), as follows: (1) If it has 15 or more employees in its aviation workforce or employed for aviation... than 15 employees in its aviation workforce or employed for aviation purposes, by taking the...

  7. Steps, Choices and Moral Accounting: Observations from a Step-Counting Campaign in the Workplace

    DEFF Research Database (Denmark)

    Gorm, Nanna; Shklovski, Irina

    2016-01-01

    Sedentary work is a contributing factor to growing obesity levels worldwide. Research shows that step-counters can offer a way to motivate greater physical mobility. We present an in-situ study of a nation-wide workplace step-counting campaign. Our findings show that in the context of the workplace...

  8. A step in the right direction: new flow depth relationships for stepped spillway design

    Science.gov (United States)

    A common deficiency for embankment dams changing from a low hazard to a high hazard dam is inadequate spillway capacity. Roller compacted concrete (RCC) stepped spillways are a popular method to address this issue. Stepped spillway research has gained momentum in recent years due to the need for d...

  9. FIRST STEP towards ICF commercialization

    International Nuclear Information System (INIS)

    Saylor, W.W.; Pendergrass, J.H.; Dudziak, D.J.

    1984-01-01

    Production of tritium for weapons and fusion R and D programs and successful development of Inertial Confinement Fusion (ICF) technologies are important national goals. A conceptual design for an ICF facility to meet these goals is presented. FIRST STEP (Fusion, Inertial, Reduced-Requirements Systems Test for Special Nuclear Material, Tritium, and Energy Production) is a concept for a plant to produce SNM, tritium, and energy while serving as a test bed for ICF technology development. A credible conceptual design for an ICF SNM and tritium production facility that competes favorably with fission technology on the bases of cost, production quality, and safety was sought. FIRST STEP is also designed to be an engineering test facility that integrates systems required for an ICF power plant and that is intermediate in scale between proof-of-principle experiment and commercial power plant. FIRST STEP driver and pellet performance requirements are moderate and represent reasonable intermediate goals in an R and D plan for ICF commercialization. Repetition rate requirements for FIRST STEP are similar to those of commercial size plants and FIRST STEP can be used to integrate systems under realistic ICF conditions

  10. Development of a Ground Test and Analysis Protocol to Support NASA's NextSTEP Phase 2 Habitation Concepts

    Science.gov (United States)

    Beaton, Kara H.; Chappell, Steven P.; Bekdash, Omar S.; Gernhardt, Michael L.

    2018-01-01

    The NASA Next Space Technologies for Exploration Partnerships (NextSTEP) program is a public-private partnership model that seeks commercial development of deep space exploration capabilities to support extensive human spaceflight missions around and beyond cislunar space. NASA first issued the Phase 1 NextSTEP Broad Agency Announcement to U.S. industries in 2014, which called for innovative cislunar habitation concepts that leveraged commercialization plans for low Earth orbit. These habitats will be part of the Deep Space Gateway (DSG), the cislunar space station planned by NASA for construction in the 2020s. In 2016, Phase 2 of the NextSTEP program selected five commercial partners to develop ground prototypes. A team of NASA research engineers and subject matter experts have been tasked with developing the ground test protocol that will serve as the primary means by which these Phase 2 prototype habitats will be evaluated. Since 2008, this core test team has successfully conducted multiple spaceflight analog mission evaluations utilizing a consistent set of operational products, tools, methods, and metrics to enable the iterative development, testing, analysis, and validation of evolving exploration architectures, operations concepts, and vehicle designs. The purpose of implementing a similar evaluation process for the NextSTEP Phase 2 Habitation Concepts is to consistently evaluate the different commercial partner ground prototypes to provide data-driven, actionable recommendations for Phase 3.

  11. Action Research on Development and Application of Internet of Things Services in Hospital.

    Science.gov (United States)

    Park, Arum; Chang, Hyejung; Lee, Kyoung Jun

    2017-01-01

    Services based on the Internet of Things (IoT) technologies have emerged in various business environments. To enhance health service quality and maximize benefits, this study applied an IoT technology based on NFC and iBeacon as an omni-channel service for patient care in hospitals. Application of the IoT technology based on NFC and iBeacon was conducted in a general hospital during August 2015 through June 2016, and the development and evaluation results were aligned to an action research framework. The five phases in the action research included diagnosing, planning action, taking action, evaluating action, and specifying learning phases. During the first two phases, problems of functional operations in a hospital were diagnosed and eight service models were designed by using iBeacon and NFC to solve the problems. Service models were applied to the hospital by installing beacons, wearable beacons, beacon scanners, and NFC tags during the third phase. During the fourth and fifth phases, the roles and benefits of stakeholders participating in the service models were evaluated, and issues and knowledge of the whole application process were derived and summarized from technological, economic, social and legal perspectives, respectively. From an action research perspective, IoT-based healthcare services were developed and verified. IoT-based services enable the hospital to acquire lifelog data for precision medicine and ultimately be able to go one step closer to precision medical care. The derived service models could provide patients more enhanced healthcare services and improve the work efficiency and effectiveness of the hospital.

  12. On the equivalence between small-step and big-step abstract machines: a simple application of lightweight fusion

    DEFF Research Database (Denmark)

    Danvy, Olivier; Millikin, Kevin

    2008-01-01

    -step specification. We illustrate this observation here with a recognizer for Dyck words, the CEK machine, and Krivine’s machine with call/cc. The need for such a simple proof is motivated by our current work on small-step abstract machines as obtained by refocusing a function implementing a reduction semantics (a...... syntactic correspondence), and big-step abstract machines as obtained by CPStransforming and then defunctionalizing a function implementing a big-step semantics (a functional correspondence). © 2007 Elsevier B.V. All rights reserved....

  13. Preliminary final programmatic environmental impact statement for the Uranium Mill Tailings Remedial Action Ground Water Project. Volume 1

    International Nuclear Information System (INIS)

    1996-01-01

    The first step in the UMTRA Ground Water Project is the preparation of this programmatic environmental impact statement (PEIS). This document analyzes the potential impacts of four alternative systems for conducting the ground water program. One of these systems is the proposed action. These alternatives do not address site-specific ground water compliance strategies, because the PEIS is a planning document only. It assesses the potential programmatic impacts of conducting the Ground Water Project, provides a method for determining the site-specific ground water compliance strategies, and provides data and information that can be used to prepare site-specific environmental impacts analyses more efficiently. This PEIS presents multiple ground water compliance strategies, each with its own set of potential impacts, that could be used to implement all the alternatives presented in the PEIS except the no action alternative. The no action alternative must be considered by law. It consists of taking no action to meet EPA standards. Implementing all PEIS alternatives (except no action) means applying a ground water compliance strategy or a combination of strategies that would result in site-specific impacts

  14. Freedom and enforcement in action a study in formal action theory

    CERN Document Server

    Czelakowski, Janusz

    2015-01-01

    Action theory is the object of growing attention in a variety of scientific disciplines, and this is the first volume to offer a synthetic view of the range of approaches possible in the topic. The volume focuses on the nexus of formal action theory with a startlingly diverse set of subjects, which range from logic, linguistics, artificial intelligence, and automata theory to jurisprudence, deontology, and economics. It covers semantic, mathematical and logical aspects of action, showing how the problem of action breaks the boundaries of traditional branches of logic located in syntactics and semantics and now lies on lies on the borderline between logical pragmatics and praxeology.   The chapters here focus on specialized tasks in formal action theory, beginning with a thorough description and formalization of the language of action, and moving through material on the differing models of action theory to focus on probabilistic models, the relations of formal action theory to deontic logic, and its key appl...

  15. SU-F-J-66: Anatomy Deformation Based Comparison Between One-Step and Two-Step Optimization for Online ART

    International Nuclear Information System (INIS)

    Feng, Z; Yu, G; Qin, S; Li, D; Ma, C; Zhu, J; Yin, Y

    2016-01-01

    Purpose: This study investigated that how the quality of adapted plan was affected by inter-fractional anatomy deformation by using one-step and two-step optimization for on line adaptive radiotherapy (ART) procedure. Methods: 10 lung carcinoma patients were chosen randomly to produce IMRT plan by one-step and two-step algorithms respectively, and the prescribed dose was set as 60 Gy on the planning target volume (PTV) for all patients. To simulate inter-fractional target deformation, four specific cases were created by systematic anatomy variation; including target superior shift 0.5 cm, 0.3cm contraction, 0.3 cm expansion and 45-degree rotation. Based on these four anatomy deformation, adapted plan, regenerated plan and non-adapted plan were created to evaluate quality of adaptation. Adapted plans were generated automatically by using one-step and two-step algorithms respectively to optimize original plans, and regenerated plans were manually created by experience physicists. Non-adapted plans were produced by recalculating the dose distribution based on corresponding original plans. The deviations among these three plans were statistically analyzed by paired T-test. Results: In PTV superior shift case, adapted plans had significantly better PTV coverage by using two-step algorithm compared with one-step one, and meanwhile there was a significant difference of V95 by comparison with adapted and non-adapted plans (p=0.0025). In target contraction deformation, with almost same PTV coverage, the total lung received lower dose using one-step algorithm than two-step algorithm (p=0.0143,0.0126 for V20, Dmean respectively). In other two deformation cases, there were no significant differences observed by both two optimized algorithms. Conclusion: In geometry deformation such as target contraction, with comparable PTV coverage, one-step algorithm gave better OAR sparing than two-step algorithm. Reversely, the adaptation by using two-step algorithm had higher efficiency

  16. SU-F-J-66: Anatomy Deformation Based Comparison Between One-Step and Two-Step Optimization for Online ART

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Z; Yu, G; Qin, S; Li, D [Shandong Normal University, Jinan, Shandong (China); Ma, C; Zhu, J; Yin, Y [Shandong Cancer Hospital and Institute, Jinan, Shandong (China)

    2016-06-15

    Purpose: This study investigated that how the quality of adapted plan was affected by inter-fractional anatomy deformation by using one-step and two-step optimization for on line adaptive radiotherapy (ART) procedure. Methods: 10 lung carcinoma patients were chosen randomly to produce IMRT plan by one-step and two-step algorithms respectively, and the prescribed dose was set as 60 Gy on the planning target volume (PTV) for all patients. To simulate inter-fractional target deformation, four specific cases were created by systematic anatomy variation; including target superior shift 0.5 cm, 0.3cm contraction, 0.3 cm expansion and 45-degree rotation. Based on these four anatomy deformation, adapted plan, regenerated plan and non-adapted plan were created to evaluate quality of adaptation. Adapted plans were generated automatically by using one-step and two-step algorithms respectively to optimize original plans, and regenerated plans were manually created by experience physicists. Non-adapted plans were produced by recalculating the dose distribution based on corresponding original plans. The deviations among these three plans were statistically analyzed by paired T-test. Results: In PTV superior shift case, adapted plans had significantly better PTV coverage by using two-step algorithm compared with one-step one, and meanwhile there was a significant difference of V95 by comparison with adapted and non-adapted plans (p=0.0025). In target contraction deformation, with almost same PTV coverage, the total lung received lower dose using one-step algorithm than two-step algorithm (p=0.0143,0.0126 for V20, Dmean respectively). In other two deformation cases, there were no significant differences observed by both two optimized algorithms. Conclusion: In geometry deformation such as target contraction, with comparable PTV coverage, one-step algorithm gave better OAR sparing than two-step algorithm. Reversely, the adaptation by using two-step algorithm had higher efficiency

  17. Microfluidic step-emulsification in axisymmetric geometry.

    Science.gov (United States)

    Chakraborty, I; Ricouvier, J; Yazhgur, P; Tabeling, P; Leshansky, A M

    2017-10-25

    Biphasic step-emulsification (Z. Li et al., Lab Chip, 2015, 15, 1023) is a promising microfluidic technique for high-throughput production of μm and sub-μm highly monodisperse droplets. The step-emulsifier consists of a shallow (Hele-Shaw) microchannel operating with two co-flowing immiscible liquids and an abrupt expansion (i.e., step) to a deep and wide reservoir. Under certain conditions the confined stream of the disperse phase, engulfed by the co-flowing continuous phase, breaks into small highly monodisperse droplets at the step. Theoretical investigation of the corresponding hydrodynamics is complicated due to the complex geometry of the planar device, calling for numerical approaches. However, direct numerical simulations of the three dimensional surface-tension-dominated biphasic flows in confined geometries are computationally expensive. In the present paper we study a model problem of axisymmetric step-emulsification. This setup consists of a stable core-annular biphasic flow in a cylindrical capillary tube connected co-axially to a reservoir tube of a larger diameter through a sudden expansion mimicking the edge of the planar step-emulsifier. We demonstrate that the axisymmetric setup exhibits similar regimes of droplet generation to the planar device. A detailed parametric study of the underlying hydrodynamics is feasible via inexpensive (two dimensional) simulations owing to the axial symmetry. The phase diagram quantifying the different regimes of droplet generation in terms of governing dimensionless parameters is presented. We show that in qualitative agreement with experiments in planar devices, the size of the droplets generated in the step-emulsification regime is independent of the capillary number and almost insensitive to the viscosity ratio. These findings confirm that the step-emulsification regime is solely controlled by surface tension. The numerical predictions are in excellent agreement with in-house experiments with the axisymmetric

  18. Digital project management the complete step-by-step guide to a successful launch

    CERN Document Server

    Olson, Taylor

    2016-01-01

    The digital world is growing and changing at a rate that can seem overwhelming to those project managers who have to keep up with it to build customer-facing solutions and applications. It's rare for project managers working in this field to be provided with much direction or a process by which to carry out a project, and there has been next to nothing available specific to these types of projects in the literary marketplace. Digital Project Management: The Complete Step-by-Step Guide to a Successful Launch was developed to fill this gap by providing the knowledge, best practices and proven steps to consistently managing these types of project successfully from end-to-end now, and in the future with just minor adjustments to adapt to changes in technology.

  19. A management approach that drives actions strategically: balanced scorecard in a mental health trust case study.

    Science.gov (United States)

    Schmidt, Stefan; Bateman, Ian; Breinlinger-O'Reilly, Jochen; Smith, Peter

    2006-01-01

    Achieving excellence is a current preoccupation in U.K. public health organisations. This article aims to use a case study to explain how a mental health trust delivers excellent performance using a balanced scorecard (BSC) management approach. Reports a project to implement a BSC approach in the South West Yorkshire Mental Health NHS Trust to achieve its "excellence" objectives. The authors were participants in the project. The design of the pilot project was informed theoretically by the work of Kaplan and Norton and practically by in-house discussions on a strategy to achieve excellence. Explains the process of building a BSC strategy step-by-step. Discusses how the vision and strategies of a mental health trust can be translated into tangible measures, which are the basis for actions that are driven strategically. There are many possibilities for a BSC management approach and this case study is specific to mental health trusts in the UK, although it is believed that the case has a universally applicable modus operandi. This article will help healthcare managers to evaluate the benefits of a BSC management approach. This article explains how actions can be structured in connection with a BSC management approach.

  20. 48 CFR 14.503-1 - Step one.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Step one. 14.503-1 Section... AND CONTRACT TYPES SEALED BIDDING Two-Step Sealed Bidding 14.503-1 Step one. (a) Requests for... use the two step method. (3) The requirements of the technical proposal. (4) The evaluation criteria...

  1. 48 CFR 14.503-2 - Step two.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Step two. 14.503-2 Section... AND CONTRACT TYPES SEALED BIDDING Two-Step Sealed Bidding 14.503-2 Step two. (a) Sealed bidding... submitting acceptable technical proposals in step one; (2) Include the provision prescribed in 14.201-6(t...

  2. Lateral step initiation behavior in older adults

    OpenAIRE

    Sparto, Patrick J; Jennings, J Richard; Furman, Joseph M; Redfern, Mark S

    2013-01-01

    Older adults have varied postural responses during induced and voluntary lateral stepping. The purpose of the research was to quantify the occurrence of different stepping strategies during lateral step initiation in older adults and to relate the stepping responses to retrospective history of falls. Seventy community-ambulating older adults (mean age 76 y, range 70–94 y) performed voluntary lateral steps as quickly as possible to the right or left in response to a visual cue, in a blocked de...

  3. Learning about goals : development of action perception and action control

    NARCIS (Netherlands)

    Verschoor, Stephan Alexander

    2014-01-01

    By using innovative paradigms, the present thesis provides convincing evidence that action-effect learning, and sensorimotor processes in general play a crucial role in the development of action- perception and production in infancy. This finding was further generalized to sequential action.

  4. Territorial Climate-Energy Plan - Le Mans region. Complete file + synthesis + Action sheets + Actor file + Appendices + Territory file

    International Nuclear Information System (INIS)

    Boulard, Jean-Claude

    2014-07-01

    A first document presents the meaning, objectives and implementation of the Territorial Climate Energy Plan (PCET) for Le Mans region, and then its five main steps: definition, diagnosis, actors, roadmap, assessment. A synthetic version is provided. Twenty action sheets are proposed, first in synthetic and general way, and then in terms of projects. These actions deal with transport and mobility, with building and development, with agriculture, forest and nature, with consumption and wastes, and with the mobilisation of actors. A document proposes sheets which describe good practices performed by Le Mans region 'syndicat mixte', by the city of Le Mans and its metropolitan body. Appendices contain some organisational information

  5. One step versus two step approach for gestational diabetes screening: systematic review and meta-analysis of the randomized trials.

    Science.gov (United States)

    Saccone, Gabriele; Caissutti, Claudia; Khalifeh, Adeeb; Meltzer, Sara; Scifres, Christina; Simhan, Hyagriv N; Kelekci, Sefa; Sevket, Osman; Berghella, Vincenzo

    2017-12-03

    To compare both the prevalence of gestational diabetes mellitus (GDM) as well as maternal and neonatal outcomes by either the one-step or the two-step approaches. Electronic databases were searched from their inception until June 2017. We included all randomized controlled trials (RCTs) comparing the one-step with the two-step approaches for the screening and diagnosis of GDM. The primary outcome was the incidence of GDM. Three RCTs (n = 2333 participants) were included in the meta-analysis. 910 were randomized to the one step approach (75 g, 2 hrs), and 1423 to the two step approach. No significant difference in the incidence of GDM was found comparing the one step versus the two step approaches (8.4 versus 4.3%; relative risk (RR) 1.64, 95%CI 0.77-3.48). Women screened with the one step approach had a significantly lower risk of preterm birth (PTB) (3.7 versus 7.6%; RR 0.49, 95%CI 0.27-0.88), cesarean delivery (16.3 versus 22.0%; RR 0.74, 95%CI 0.56-0.99), macrosomia (2.9 versus 6.9%; RR 0.43, 95%CI 0.22-0.82), neonatal hypoglycemia (1.7 versus 4.5%; RR 0.38, 95%CI 0.16-0.90), and admission to neonatal intensive care unit (NICU) (4.4 versus 9.0%; RR 0.49, 95%CI 0.29-0.84), compared to those randomized to screening with the two step approach. The one and the two step approaches were not associated with a significant difference in the incidence of GDM. However, the one step approach was associated with better maternal and perinatal outcomes.

  6. Self-Adaptive Step Firefly Algorithm

    Directory of Open Access Journals (Sweden)

    Shuhao Yu

    2013-01-01

    Full Text Available In the standard firefly algorithm, each firefly has the same step settings and its values decrease from iteration to iteration. Therefore, it may fall into the local optimum. Furthermore, the decreasing of step is restrained by the maximum of iteration, which has an influence on the convergence speed and precision. In order to avoid falling into the local optimum and reduce the impact of the maximum of iteration, a self-adaptive step firefly algorithm is proposed in the paper. Its core idea is setting the step of each firefly varying with the iteration, according to each firefly’s historical information and current situation. Experiments are made to show the performance of our approach compared with the standard FA, based on sixteen standard testing benchmark functions. The results reveal that our method can prevent the premature convergence and improve the convergence speed and accurateness.

  7. The use of innovation action research approach in the preparation of a regulation on costing standard 

    Directory of Open Access Journals (Sweden)

    Monika Raulinajtys-Grzybek

    2016-04-01

    Full Text Available The article analyzes the applicability of the innovation action research method for activities related to the preparation of a concept of a costing standard for healthcare providers which is subject to legal regula- tion. This legislation regulates the way providers, reporting data for the purpose of the regulated pricing of health services, identify and calculate costs. A 39-month long research project was carried out in ac- cordance with the innovation action research approach, which resulted in the creation of a novel concept of a costing model. The generation of new knowledge occurred as a result of a collaboration between researchers and practitioners, which is a basic assumption of action research. The consecutive steps of the research have been characterized in order to present the influence of the research method on the devel- opment and modification of the initial concept.

  8. Eighth International Chorea–Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points

    Directory of Open Access Journals (Sweden)

    Samuel S. Pappas

    2017-02-01

    Full Text Available Chorea-Acanthocytosis (ChAc is a rare hereditary neurological disorder characterized by abnormal movements, red blood cell pathology, and progressive neurodegeneration. Little is understood of the pathogenesis of ChAc and related disorders (collectively Neuroacanthocytosis. The Eighth International Chorea-Acanthocytosis Symposium was held in May 2016 in Ann Arbor, MI, USA, and focused on molecular mechanisms driving ChAc pathophysiology. Accompanying the meeting, members of the neuroacanthocytosis research community and other invited scientists met in a workshop to discuss the current understanding and next steps needed to better understand ChAc pathogenesis. These discussions identified several broad and critical needs for advancing ChAc research and patient care, and led to the definition of 18 specific action points related to functional and molecular studies, animal models, and clinical research. These action points, described below, represent tractable research goals to pursue for the next several years.

  9. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol

    Directory of Open Access Journals (Sweden)

    Agnete eKirkeby

    2013-01-01

    Full Text Available Human pluripotent stem cells possess the potential to generate cells for regenerative therapies in patients with neurodegenerative diseases, and constitute an excellent cell source for studying human neural development and disease modeling. Protocols for neural differentiation of human pluripotent stem cells have undergone significant progress during recent years, allowing for rapid and synchronized neural conversion. Differentiation procedures can further be combined with accurate and efficient positional patterning to yield regionalized neural progenitors and subtype-specific neurons corresponding to different parts of the developing human brain. Here, we present a step-by-step protocol for neuralization and regionalization of human pluripotent cells for transplantation studies or in vitro analysis.

  10. Corrective Action Investigation Plan for Corrective Action Unit 410: Waste Disposal Trenches, Tonopah Test Range, Nevada, Revision 0 (includes ROTCs 1, 2, and 3)

    Energy Technology Data Exchange (ETDEWEB)

    NNSA/NV

    2002-07-16

    uranium, beryllium, total petroleum hydrocarbons; and total Resource Conservation and Recovery Act metals. Field activities will consist of geophysical and radiological surveys, and collecting soil samples at biased locations by appropriate methods. A two-step data quality objective strategy will be followed: (1) define the nature of contamination at each CAS location by identifying any contamination above preliminary action levels (PALs); and, (2) determine the extent of contamination identified above PALs. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document.

  11. Enforcement actions: Significant actions resolved individual actions. Semiannual progress report, January 1996--June 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    This document summarizes significant enforcement actions that have been resolved during the period of January-June 1996. The report includes copies of Orders and Notices of Violations sent by the Nuclear Regulatory Commission to individuals with respect to the enforcement actions.

  12. Enforcement actions: Significant actions resolved individual actions. Semiannual progress report, January 1996--June 1996

    International Nuclear Information System (INIS)

    1996-08-01

    This document summarizes significant enforcement actions that have been resolved during the period of January-June 1996. The report includes copies of Orders and Notices of Violations sent by the Nuclear Regulatory Commission to individuals with respect to the enforcement actions

  13. Creativity as action

    DEFF Research Database (Denmark)

    Glaveanu, Vlad Petre; Lubart, Todd; Bonnardel, Nathalie

    2013-01-01

    The present paper outlines an action theory of creativity and substantiates this approach by investigating creative expression in five different domains. We propose an action framework for the analysis of creative acts built on the assumption that creativity is a relational, inter......, science, scriptwriting, and music. Results point to complex models of action and inter-action specific for each domain and also to interesting patterns of similarity and differences between domains. These findings highlight the fact that creative action takes place not “inside” individual creators but “in...

  14. Voluntary stepping behavior under single- and dual-task conditions in chronic stroke survivors: A comparison between the involved and uninvolved legs.

    Science.gov (United States)

    Melzer, Itshak; Goldring, Melissa; Melzer, Yehudit; Green, Elad; Tzedek, Irit

    2010-12-01

    If balance is lost, quick step execution can prevent falls. Research has shown that speed of voluntary stepping was able to predict future falls in old adults. The aim of the study was to investigate voluntary stepping behavior, as well as to compare timing and leg push-off force-time relation parameters of involved and uninvolved legs in stroke survivors during single- and dual-task conditions. We also aimed to compare timing and leg push-off force-time relation parameters between stroke survivors and healthy individuals in both task conditions. Ten stroke survivors performed a voluntary step execution test with their involved and uninvolved legs under two conditions: while focusing only on the stepping task and while a separate attention-demanding task was performed simultaneously. Temporal parameters related to the step time were measured including the duration of the step initiation phase, the preparatory phase, the swing phase, and the total step time. In addition, force-time parameters representing the push-off power during stepping were calculated from ground reaction data and compared with 10 healthy controls. The involved legs of stroke survivors had a significantly slower stepping time than uninvolved legs due to increased swing phase duration during both single- and dual-task conditions. For dual compared to single task, the stepping time increased significantly due to a significant increase in the duration of step initiation. In general, the force time parameters were significantly different in both legs of stroke survivors as compared to healthy controls, with no significant effect of dual compared with single-task conditions in both groups. The inability of stroke survivors to swing the involved leg quickly may be the most significant factor contributing to the large number of falls to the paretic side. The results suggest that stroke survivors were unable to rapidly produce muscle force in fast actions. This may be the mechanism of delayed execution

  15. A small step for mankind

    NARCIS (Netherlands)

    Huizing, C.; Koymans, R.L.C.; Kuiper, R.; Dams, D.; Hannemann, U.; Steffen, M.

    2010-01-01

    For many programming languages, the only formal semantics published is an SOS big-step semantics. Such a semantics is not suited for investigations that observe intermediate states, such as invariant techniques. In this paper, a construction is proposed that generates automatically a small-step SOS

  16. From quality control to quality systems in x-ray radiology. Step by step approach

    International Nuclear Information System (INIS)

    Gendrutis Morkunas; Julius Ziliukas

    2007-01-01

    Complete test of publication follows. Quality systems in x-ray radiology as in any area of medical exposure is an important tool of optimization of radiation protection. Creation of these systems is related with a number of problems: limited resources, lack of knowledge and experience, negative attitude of hospitals staff and administration, lack of advice from outside. Problems related with transitionary period might be softened by the step by step approach. The following steps might be indicated: providing information on quality systems to hospital staff and administration, simple quality control procedures done by outside experts in hospitals, preparation of quality related procedures by hospital staff, practical implementation of quality control procedures done by hospital staff, preparation of quality manual by hospital staff, its integration into common quality system of hospital (if it is available) and constant development, measurements of performance indicators (e.g., patients' doses) and introduction of corrective measures if necessary, dissemination of experience by expert organizations and more advanced hospitals. These steps are to be discussed in the presentations based on Lithuanian experience since 1998.

  17. High accuracy step gauge interferometer

    Science.gov (United States)

    Byman, V.; Jaakkola, T.; Palosuo, I.; Lassila, A.

    2018-05-01

    Step gauges are convenient transfer standards for the calibration of coordinate measuring machines. A novel interferometer for step gauge calibrations implemented at VTT MIKES is described. The four-pass interferometer follows Abbe’s principle and measures the position of the inductive probe attached to a measuring head. The measuring head of the instrument is connected to a balanced boom above the carriage by a piezo translation stage. A key part of the measuring head is an invar structure on which the inductive probe and the corner cubes of the measuring arm of the interferometer are attached. The invar structure can be elevated so that the probe is raised without breaking the laser beam. During probing, the bending of the probe and the interferometer readings are recorded and the measurement face position is extrapolated to zero force. The measurement process is fully automated and the face positions of the steps can be measured up to a length of 2 m. Ambient conditions are measured continuously and the refractive index of air is compensated for. Before measurements the step gauge is aligned with an integrated 2D coordinate measuring system. The expanded uncertainty of step gauge calibration is U=\\sqrt{{{(64 nm)}2}+{{(88× {{10}-9}L)}2}} .

  18. Evaluating Web-Scale Discovery Services: A Step-by-Step Guide

    Directory of Open Access Journals (Sweden)

    Joseph Deodato

    2015-06-01

    Full Text Available Selecting a web-scale discovery service is a large and important undertaking that involves a significant investment of time, staff, and resources. Finding the right match begins with a thorough and carefully planned evaluation process. In order to be successful, this process should be inclusive, goal-oriented, data-driven, user-centered, and transparent. The following article offers a step-by-step guide for developing a web-scale discovery evaluation plan rooted in these five key principles based on best practices synthesized from the literature as well as the author’s own experiences coordinating the evaluation process at Rutgers University. The goal is to offer academic libraries that are considering acquiring a web-scale discovery service a blueprint for planning a structured and comprehensive evaluation process.

  19. The effective action

    International Nuclear Information System (INIS)

    DeWitt, B.

    1987-01-01

    The concept of the effective action in quantum field theory was introduced into physics by Julian Schwinger in 1954. The effective action summarizes, in a single functional, all the quantum properties of the fields under consideration. The functional derivative of the effective action yields the effective field equations, which replace the classical field equations as descriptors of the dynamical behavior of quantized fields. Solutions of these equations are 'in-out' matrix elements of the field operators and, when substituted back into the effective action itself, yield logarithms of the corresponding 'in-out' amplitudes. The classical field equations are gauge covariant, a fact that derives from the gauge invariance of the classical action. One has learned how to construct effective actions that are similarly gauge invariant (in each order of perturbation theory) and that yield effective field equations having the covariance properties of their classical analogs. Despite this advance, problems remain, stemming from the fact that there is not one but an infinite number of gauge invariant effective actions, one for every background-covariant choice of supplementary conditions and ghost fields. Vilkovisky (1984) has argued persuasively that by requiring additionally that the effective action be invariant under local invertible changes in the choice of basic field variables, one can construct a natural unique gauge invariant effective action. This lecture will examine Vilkovisky's ideas. 3 refs

  20. Step-to-step variability in treadmill walking: influence of rhythmic auditory cueing.

    Directory of Open Access Journals (Sweden)

    Philippe Terrier

    Full Text Available While walking, human beings continuously adjust step length (SpL, step time (SpT, step speed (SpS = SpL/SpT and step width (SpW by integrating both feedforward and feedback mechanisms. These motor control processes result in correlations of gait parameters between consecutive strides (statistical persistence. Constraining gait with a speed cue (treadmill and/or a rhythmic auditory cue (metronome, modifies the statistical persistence to anti-persistence. The objective was to analyze whether the combined effect of treadmill and rhythmic auditory cueing (RAC modified not only statistical persistence, but also fluctuation magnitude (standard deviation, SD, and stationarity of SpL, SpT, SpS and SpW. Twenty healthy subjects performed 6 × 5 min. walking tests at various imposed speeds on a treadmill instrumented with foot-pressure sensors. Freely-chosen walking cadences were assessed during the first three trials, and then imposed accordingly in the last trials with a metronome. Fluctuation magnitude (SD of SpT, SpL, SpS and SpW was assessed, as well as NonStationarity Index (NSI, which estimates the dispersion of local means in the times series (SD of 20 local means over 10 steps. No effect of RAC on fluctuation magnitude (SD was observed. SpW was not modified by RAC, what is likely the evidence that lateral foot placement is separately regulated. Stationarity (NSI was modified by RAC in the same manner as persistent pattern: Treadmill induced low NSI in the time series of SpS, and high NSI in SpT and SpL. On the contrary, SpT, SpL and SpS exhibited low NSI under RAC condition. We used relatively short sample of consecutive strides (100 as compared to the usual number of strides required to analyze fluctuation dynamics (200 to 1000 strides. Therefore, the responsiveness of stationarity measure (NSI to cued walking opens the perspective to perform short walking tests that would be adapted to patients with a reduced gait perimeter.

  1. Experiencing Action Evaluation's Cyclic Process: Partnering Conflict, Reflection, and Action

    Science.gov (United States)

    Burrows, Andrea C.; Harkness, Shelly Sheats

    2016-01-01

    In this article, the authors describe experiences in and offer suggestions from a course entitled "Educational Innovation for Excellence Through Action Research, Conflict Resolution, and Organizational Learning"--an action evaluation (AE). The class was taught using the principles of action research and AE. The authors explore the impact…

  2. Step-Up DC-DC converters

    DEFF Research Database (Denmark)

    Forouzesh, Mojtaba; Siwakoti, Yam P.; Gorji, Saman A.

    2017-01-01

    on the general law and framework of the development of next-generation step-up dc-dc converters, this paper aims to comprehensively review and classify various step-up dc-dc converters based on their characteristics and voltage-boosting techniques. In addition, the advantages and disadvantages of these voltage...

  3. Sintering uranium oxide using a preheating step

    International Nuclear Information System (INIS)

    Jensen, N.J.; Nivas, Y.; Packard, D.R.

    1977-01-01

    Compacted pellets of uranium oxide or uranium oxide with one or more additives are heated in a kiln in a process having a preheating step, a sintering step, a reduction step, and a cooling step in a controlled atmosphere. The process is practiced to give a range of temperature and atmosphere conditions for obtaining optimum fluoride removal from the compacted pellets along with optimum sintering in a single process. The preheating step of this process is conducted in a temperature range of about 600 0 to about 900 0 C and the pellets are held for at least twenty min, and preferably about 60 min, in an atmosphere having a composition in the range of about 10 to about 75 vol % hydrogen with the balance being carbon dioxide. The sintering step is conducted at a temperature in the range of about 900 0 C to 1500 0 C in the presence of an atmosphere having a composition in the range of about 0.5 to about 90 vol % hydrogen with the balance being carbon dioxide. The reduction step reduces the oxygen to metal ratio of the pellets to a range of about 1.98 to 2.10:1 and this is accomplished by gradually cooling the pellets for about 30 to about 120 min from the temperature of the sintering step to about 1100 0 C in an atmosphere of about 10 to 90 vol % hydrogen with the balance being carbon dioxide. Thereafter the pellets are cooled to about 100 0 C under a protective atmosphere, and in one preferred practice the same atmosphere used in the reduction step is used in the cooling step. The preheating, sintering and reduction steps may also be conducted with their respective atmospheres having an initial additional component of water vapor and the water vapor can comprise up to about 20 vol %

  4. Action simulation plays a critical role in deceptive action recognition.

    Science.gov (United States)

    Tidoni, Emmanuele; Borgomaneri, Sara; di Pellegrino, Giuseppe; Avenanti, Alessio

    2013-01-09

    The ability to infer deceptive intents from nonverbal behavior is critical for social interactions. By combining single-pulse and repetitive transcranial magnetic stimulation (TMS) in healthy humans, we provide both correlational and causative evidence that action simulation is actively involved in the ability to recognize deceptive body movements. We recorded motor-evoked potentials during a faked-action discrimination (FAD) task: participants watched videos of actors lifting a cube and judged whether the actors were trying to deceive them concerning the real weight of the cube. Seeing faked actions facilitated the observers' motor system more than truthful actions in a body-part-specific manner, suggesting that motor resonance was sensitive to deceptive movements. Furthermore, we found that TMS virtual lesion to the anterior node of the action observation network, namely the left inferior frontal cortex (IFC), reduced perceptual sensitivity in the FAD task. In contrast, no change in FAD task performance was found after virtual lesions to the left temporoparietal junction (control site). Moreover, virtual lesion to the IFC failed to affect performance in a difficulty-matched spatial-control task that did not require processing of spatiotemporal (acceleration) and configurational (limb displacement) features of seen actions, which are critical to detecting deceptive intent in the actions of others. These findings indicate that the human IFC is critical for recognizing deceptive body movements and suggest that FAD relies on the simulation of subtle changes in action kinematics within the motor system.

  5. Surface deformation during an action potential in pearled cells

    Science.gov (United States)

    Mussel, Matan; Fillafer, Christian; Ben-Porath, Gal; Schneider, Matthias F.

    2017-11-01

    Electric pulses in biological cells (action potentials) have been reported to be accompanied by a propagating cell-surface deformation with a nanoscale amplitude. Typically, this cell surface is covered by external layers of polymer material (extracellular matrix, cell wall material, etc.). It was recently demonstrated in excitable plant cells (Chara braunii) that the rigid external layer (cell wall) hinders the underlying deformation. When the cell membrane was separated from the cell wall by osmosis, a mechanical deformation, in the micrometer range, was observed upon excitation of the cell. The underlying mechanism of this mechanical pulse has, to date, remained elusive. Herein we report that Chara cells can undergo a pearling instability, and when the pearled fragments were excited even larger and more regular cell shape changes were observed (˜10 -100 μ m in amplitude). These transient cellular deformations were captured by a curvature model that is based on three parameters: surface tension, bending rigidity, and pressure difference across the surface. In this paper these parameters are extracted by curve-fitting to the experimental cellular shapes at rest and during excitation. This is a necessary step to identify the mechanical parameters that change during an action potential.

  6. Step sites in syngas catalysis

    DEFF Research Database (Denmark)

    Rostrup-Nielsen, J.; Nørskov, Jens Kehlet

    2006-01-01

    Step sites play an important role in many catalytic reactions. This paper reviews recent results on metal catalysts for syngas reactions with emphasis on steam reforming. Modern characterization techniques (STEM, HREM...) and theoretical calculations (DFT) has allowed a more quantitative explanat......Step sites play an important role in many catalytic reactions. This paper reviews recent results on metal catalysts for syngas reactions with emphasis on steam reforming. Modern characterization techniques (STEM, HREM...) and theoretical calculations (DFT) has allowed a more quantitative...... explanation of the impact of step sites on catalyst activity and side reactions such as carbon formation. This leads to a discussion of principles for catalyst promotion....

  7. Microcomputer-based stepping-motor controller

    International Nuclear Information System (INIS)

    Johnson, K.

    1983-04-01

    A microcomputer-controlled stepping motor is described. A Motorola MC68701 microcomputer unit is interfaced to a Cybernetic CY500 stored-program controller that outputs through Motorola input/output isolation modules to the stepping motor. A complex multifunction controller with enhanced capabilities is thus available with a minimum number of parts

  8. Intermediate surface structure between step bunching and step flow in SrRuO3 thin film growth

    Science.gov (United States)

    Bertino, Giulia; Gura, Anna; Dawber, Matthew

    We performed a systematic study of SrRuO3 thin films grown on TiO2 terminated SrTiO3 substrates using off-axis magnetron sputtering. We investigated the step bunching formation and the evolution of the SRO film morphology by varying the step size of the substrate, the growth temperature and the film thickness. The thin films were characterized using Atomic Force Microscopy and X-Ray Diffraction. We identified single and multiple step bunching and step flow growth regimes as a function of the growth parameters. Also, we clearly observe a stronger influence of the step size of the substrate on the evolution of the SRO film surface with respect to the other growth parameters. Remarkably, we observe the formation of a smooth, regular and uniform ``fish skin'' structure at the transition between one regime and another. We believe that the fish skin structure results from the merging of 2D flat islands predicted by previous models. The direct observation of this transition structure allows us to better understand how and when step bunching develops in the growth of SrRuO3 thin films.

  9. A Three Step B2B Sales Model Based on Satisfaction Judgments

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe

    2015-01-01

    . The insights produces can be applied for selling companies to craft close collaborative customer relationships in a systematic a d efficient way. The process of building customer relationships will be guided through actions that yields higher satisfaction judgments leading to loyal customers and finally......This paper aims to provide a coherent, detailed and integrative understanding of the mental processes (i.e. dimensions) that industrial buyers apply when forming satisfaction judgments in adjacent to new task buying situations. A qualitative inductive research strategy is utilized in this study...... companies’ perspective. The buying center members applied satisfaction dimension when forming satisfaction judgments. Moreover, the focus and importance of the identified satisfaction dimensions fluctuated pending on the phase of the buying process. Based on the findings a three step sales model is proposed...

  10. A Three Step B2B Sales Model Based on Satisfaction Judgments

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe

    2015-01-01

    . The insights produces can be applied for selling companies to craft close collaborative customer relationships in a systematic ad efficient way. The process of building customer relationships will be guided through actions that yields higher satisfaction judgments leading to loyal customers and finally......This paper aims to provide a coherent, detailed and integrative understanding of the mental processes (i.e. dimensions) that industrial buyers apply when forming satisfaction judgments in adjacent to new task buying situations. A qualitative inductive research strategy is utilized in this study...... companies‘ perspective. The buying center members applied satisfaction dimension when forming satisfaction judgments. Moreover, the focus and importance of the identified satisfaction dimensions fluctuated pending on the phase of the buying process. Based on the findings a three step sales model is proposed...

  11. Multimodal responsive action

    DEFF Research Database (Denmark)

    Oshima, Sae

    ; Raymond 2003; Schegloff and Lerner 2009), including those with multimodal actions (e.g. Olsher 2004; Fasulo & Monzoni 2009). Some responsive actions can also be completed with bodily behavior alone, such as: when an agreement display is achieved by using only nonvocal actions (Jarmon 1996), when...... the recipient’s gaze shift becomes a significant part of the speaker’s turn construction (Goodwin 1980), and when head nods show the recipient’s affiliation with the speaker’s stance (Stivers 2008). Still, much room remains for extending our current understanding of responding actions that necessarily involve...... a hairstylist and a client negotiate the quality of the service that has been provided. Here, the first action is usually the stylist’s question and/or explanation of the new cut that invites the client’s assessment/(dis)agreement, accompanied with embodied actions that project an imminent self...

  12. Absence of modulatory action on haptic height perception with musical pitch

    Directory of Open Access Journals (Sweden)

    Michele eGeronazzo

    2015-09-01

    Full Text Available Although acoustic frequency is not a spatial property of physical objects, in common language, pitch, i.e., the psychological correlated of frequency, is often labeled spatially (i.e., high in pitch or low in pitch. Pitch-height is known to modulate (and interact with the response of participants when they are asked to judge spatial properties of non-auditory stimuli (e.g., visual in a variety of behavioral tasks. In the current study we investigated whether the modulatory action of pitch-height extended to the haptic estimation of height of a virtual step.We implemented a HW/SW setup which is able to render virtual 3D objects (stair-steps haptically through a PHANTOM device, and to provide real-time continuous auditory feedback depending on the user interaction with the object. The haptic exploration was associated with a sinusoidal tone whose pitch varied as a function of the interaction point’s height within (i a narrower and (ii a wider pitch range, or (iii a random pitch variation acting as a control audio condition. Explorations were also performed with no sound (haptic only. Participants were instructed to explore the virtual step freely, and to communicate height estimation by opening their thumb and index finger to mimic the step riser height, or verbally by reporting the height in centimeters of the step riser. We analyzed the role of musical expertise by dividing participants into non musicians and musicians. Results showed no effects of musical pitch on high-realistic haptic feedback. Overall there is no difference between the two groups in the proposed multimodal conditions. Additionally, we observed a different haptic response distribution between musicians and non musicians when estimations of the auditory conditions are matched with estimations in the no sound condition.

  13. Inferring Action Structure and Causal Relationships in Continuous Sequences of Human Action

    Science.gov (United States)

    2014-01-01

    and MySQL . However, all participants participated from in-lab computers. Results Figure 6 shows the distribution of participants’ raw key presses... Java program to present video of action sequences and collect ratings. The program presented all 12 actions, non-actions, and part-actions

  14. RCRA corrective action determination of no further action

    International Nuclear Information System (INIS)

    1996-06-01

    On July 27, 1990, the U.S. Environmental Protection Agency (EPA) proposed a regulatory framework (55 FR 30798) for responding to releases of hazardous waste and hazardous constituents from solid waste management units (SWMUs) at facilities seeking permits or permitted under the Resource Conservation and Recovery Act (RCRA). The proposed rule, 'Corrective Action for Solid Waste Management Units at Hazardous Waste Facilities', would create a new Subpart S under the 40 CFR 264 regulations, and outlines requirements for conducting RCRA Facility Investigations, evaluating potential remedies, and selecting and implementing remedies (i.e., corrective measures) at RCRA facilities. EPA anticipates instances where releases or suspected releases of hazardous wastes or constituents from SWMUs identified in a RCRA Facility Assessment, and subsequently addressed as part of required RCRA Facility Investigations, will be found to be non-existent or non-threatening to human health or the environment. Such releases may require no further action. For such situations, EPA proposed a mechanism for making a determination that no further corrective action is needed. This mechanism is known as a Determination of No Further Action (DNFA) (55 FR 30875). This information Brief describes what a DNFA is and discusses the mechanism for making a DNFA. This is one of a series of Information Briefs on RCRA corrective action

  15. Self-estimation of physical ability in stepping over an obstacle is not mediated by visual height perception: a comparison between young and older adults.

    Science.gov (United States)

    Sakurai, Ryota; Fujiwara, Yoshinori; Ishihara, Masami; Yasunaga, Masashi; Ogawa, Susumu; Suzuki, Hiroyuki; Imanaka, Kuniyasu

    2017-07-01

    Older adults tend to overestimate their step-over ability. However, it is unclear as to whether this is caused by inaccurate self-estimation of physical ability or inaccurate perception of height. We, therefore, measured both visual height perception ability and self-estimation of step-over ability among young and older adults. Forty-seven older and 16 young adults performed a height perception test (HPT) and a step-over test (SOT). Participants visually judged the height of vertical bars from distances of 7 and 1 m away in the HPT, then self-estimated and, subsequently, actually performed a step-over action in the SOT. The results showed no significant difference between young and older adults in visual height perception. In the SOT, young adults tended to underestimate their step-over ability, whereas older adults either overestimated their abilities or underestimated them to a lesser extent than did the young adults. Moreover, visual height perception was not correlated with the self-estimation of step-over ability in both young and older adults. These results suggest that the self-overestimation of step-over ability which appeared in some healthy older adults may not be caused by the nature of visual height perception, but by other factor(s), such as the likely age-related nature of self-estimation of physical ability, per se.

  16. Normative Action Research

    DEFF Research Database (Denmark)

    Baboroglu, Oguz; Ravn, Ib

    1992-01-01

    This paper presents an argument for an enrichment of action research methodology. To the current state of action research, we add a constructivist epistemological argument, as well as a crucial inspiration from some futures-oriented planning approaches. Within the domain of social....... They are generated jointly by the stakeholders of a system and the involved action researchers and are tested every time that the prescriptions for action contained in them are followed by a system's stakeholders....

  17. Effect of actions promoting healthy eating on students' lipid profile: A controlled trial

    Directory of Open Access Journals (Sweden)

    Rita De Cássia Ribeiro-Silva

    2014-04-01

    Full Text Available OBJECTIVE: To assess the effect of nutrition intervention actions on the lipid profile of children and adolescents enrolled in public elementary schools. METHODS: This nine-month, controlled, intervention study included 202 students aged 7 to 14 years attending two schools (intervention/control located in a poor neighborhood of the municipality of Salvador, Bahia, Brazil. Actions were implemented in the intervention school to promote healthy eating habits, presented as "Ten steps to healthy eating". The effect of these actions was assessed by subjecting the students at baseline and end of the follow-up to biochemical, maturation, and anthropometric measurements and a produce intake survey. The dependent variables were the changes in the study biochemical parameters: total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, and triglycerides. Analysis of covariance assessed the changes that occurred over the study period. RESULTS: The mean total cholesterol, low-density lipoprotein-cholesterol, and triglycerides of the intervention students decreased 13.18 mg/dL (p=0.001, 7.41 mg/dL (p=0.038, and 12.37 mg/dL (p=0.029, respectively, compared with the control students. CONCLUSION: Actions of this nature have a positive impact on lipid profile. This study adds to those that use effective and viable public health strategies implementable at the primary care level.

  18. Final programmatic environmental impact statement for the Uranium Mill Tailings Remedial Action Ground Water Project. Volume 2

    International Nuclear Information System (INIS)

    1996-10-01

    The purpose of the Uranium Mill Tailings Remedial Action (UMTRA) Ground Water Project is to eliminate, reduce, or address to acceptable levels the potential health and environmental consequences of milling activities. One of the first steps in the UMTRA Ground Water Project is the preparation of the Programmatic Environmental Impact Statement (PEIS). This report contains the comments and responses received on the draft PEIS

  19. Emotions and action

    NARCIS (Netherlands)

    Frijda, N.H.; Manstead, A.S.R.; Frijda, N.H.; Fischer, A.H.

    2004-01-01

    This chapter discusses the relationships between emotion and action. Emotion, by its very nature, is change in action readiness to maintain or change one's relationship to an object or event. Motivation, or motivational change, is one of the key aspects of emotions. Even so, action follows only

  20. Listen to Me Listen to You: A Step-By-Step Guide to Communication Skills Training

    Science.gov (United States)

    Kotzman, Mandy; Kotzman, Anne

    2008-01-01

    This step-by-step guide is a companion to the popular "Listen to Me, Listen to You: A Practical Guide to Self-Awareness, Communication Skills and Conflict Management" (New Expanded Edition, Penguin Books, 2007). It is designed for use by anyone working in communication skills and personal development training. Resource material is grouped under…

  1. Using Action Research to Engage K-6 Teachers in Nature of Science Inquiry as Professional Development

    Science.gov (United States)

    Cullen, Theresa A.; Akerson, Valarie L.; Hanson, Deborah L.

    2010-12-01

    Teachers are required to work with data on a daily basis to assess the effectiveness of their teaching strategies, but may not approach it as research. This paper presents a reflective discussion of how and when a professional development team used an action research project to help 12 K-6 teachers explore the effectiveness of reform based Nature of Science (NOS) teaching strategies in their classrooms. The team encouraged community development and provided “just in time” supports to scaffold the steps of the action research process for teachers. The discussion includes concerns they addressed and issues related to management and support of the professional development model. Evaluation results are shared to suggest how this approach can be improved in the future.

  2. Solar-driven thermo- and electrochemical degradation of nitrobenzene in wastewater: Adaptation and adoption of solar STEP concept.

    Science.gov (United States)

    Gu, Di; Shao, Nan; Zhu, Yanji; Wu, Hongjun; Wang, Baohui

    2017-01-05

    The STEP concept has successfully been demonstrated for driving chemical reaction by utilization of solar heat and electricity to minimize the fossil energy, meanwhile, maximize the rate of thermo- and electrochemical reactions in thermodynamics and kinetics. This pioneering investigation experimentally exhibit that the STEP concept is adapted and adopted efficiently for degradation of nitrobenzene. By employing the theoretical calculation and thermo-dependent cyclic voltammetry, the degradation potential of nitrobenzene was found to be decreased obviously, at the same time, with greatly lifting the current, while the temperature was increased. Compared with the conventional electrochemical methods, high efficiency and fast degradation rate were markedly displayed due to the co-action of thermo- and electrochemical effects and the switch of the indirect electrochemical oxidation to the direct one for oxidation of nitrobenzene. A clear conclusion on the mechanism of nitrobenzene degradation by the STEP can be schematically proposed and discussed by the combination of thermo- and electrochemistry based the analysis of the HPLC, UV-vis and degradation data. This theory and experiment provide a pilot for the treatment of nitrobenzene wastewater with high efficiency, clean operation and low carbon footprint, without any other input of energy and chemicals from solar energy. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Additive Routes to Action Learning: Layering Experience Shapes Engagement of the Action Observation Network.

    Science.gov (United States)

    Kirsch, Louise P; Cross, Emily S

    2015-12-01

    The way in which we perceive others in action is biased by one's prior experience with an observed action. For example, we can have auditory, visual, or motor experience with actions we observe others perform. How action experience via 1, 2, or all 3 of these modalities shapes action perception remains unclear. Here, we combine pre- and post-training functional magnetic resonance imaging measures with a dance training manipulation to address how building experience (from auditory to audiovisual to audiovisual plus motor) with a complex action shapes subsequent action perception. Results indicate that layering experience across these 3 modalities activates a number of sensorimotor cortical regions associated with the action observation network (AON) in such a way that the more modalities through which one experiences an action, the greater the response is within these AON regions during action perception. Moreover, a correlation between left premotor activity and participants' scores for reproducing an action suggests that the better an observer can perform an observed action, the stronger the neural response is. The findings suggest that the number of modalities through which an observer experiences an action impacts AON activity additively, and that premotor cortical activity might serve as an index of embodiment during action observation. © The Author 2015. Published by Oxford University Press.

  4. Comparison of the Screening Tests for Gestational Diabetes Mellitus between "One-Step" and "Two-Step" Methods among Thai Pregnant Women.

    Science.gov (United States)

    Luewan, Suchaya; Bootchaingam, Phenphan; Tongsong, Theera

    2018-01-01

    To compare the prevalence and pregnancy outcomes of GDM between those screened by the "one-step" (75 gm GTT) and "two-step" (100 gm GTT) methods. A prospective study was conducted on singleton pregnancies at low or average risk of GDM. All were screened between 24 and 28 weeks, using the one-step or two-step method based on patients' preference. The primary outcome was prevalence of GDM, and secondary outcomes included birthweight, gestational age, rates of preterm birth, small/large-for-gestational age, low Apgar scores, cesarean section, and pregnancy-induced hypertension. A total of 648 women were screened: 278 in the one-step group and 370 in the two-step group. The prevalence of GDM was significantly higher in the one-step group; 32.0% versus 10.3%. Baseline characteristics and pregnancy outcomes in both groups were comparable. However, mean birthweight was significantly higher among pregnancies with GDM diagnosed by the two-step approach (3204 ± 555 versus 3009 ± 666 g; p =0.022). Likewise, the rate of large-for-date tended to be higher in the two-step group, but was not significant. The one-step approach is associated with very high prevalence of GDM among Thai population, without clear evidence of better outcomes. Thus, this approach may not be appropriate for screening in a busy antenatal care clinic like our setting or other centers in developing countries.

  5. Symplectic integrators with adaptive time steps

    Science.gov (United States)

    Richardson, A. S.; Finn, J. M.

    2012-01-01

    In recent decades, there have been many attempts to construct symplectic integrators with variable time steps, with rather disappointing results. In this paper, we identify the causes for this lack of performance, and find that they fall into two categories. In the first, the time step is considered a function of time alone, Δ = Δ(t). In this case, backward error analysis shows that while the algorithms remain symplectic, parametric instabilities may arise because of resonance between oscillations of Δ(t) and the orbital motion. In the second category the time step is a function of phase space variables Δ = Δ(q, p). In this case, the system of equations to be solved is analyzed by introducing a new time variable τ with dt = Δ(q, p) dτ. The transformed equations are no longer in Hamiltonian form, and thus do not benefit from integration methods which would be symplectic for Hamiltonian systems. We analyze two methods for integrating the transformed equations which do, however, preserve the structure of the original equations. The first is an extended phase space method, which has been successfully used in previous studies of adaptive time step symplectic integrators. The second, novel, method is based on a non-canonical mixed-variable generating function. Numerical trials for both of these methods show good results, without parametric instabilities or spurious growth or damping. It is then shown how to adapt the time step to an error estimate found by backward error analysis, in order to optimize the time-stepping scheme. Numerical results are obtained using this formulation and compared with other time-stepping schemes for the extended phase space symplectic method.

  6. Blogging business step-by-step startup guide

    CERN Document Server

    magazine, Entrepreneur

    2014-01-01

    This kit includes: Essential industry and business-specific startup steps with worksheets, calculators, checklists and more. Entrepreneur Editors' Start Your Own Business, a guide to starting any business and surviving the first three years. Downloadable, customizable business letters, sales letters, and other sample documents. Entrepreneur's Small Business Legal Toolkit. Blogs are still one of the internet's fastest-growing phenomena–and one of the best and easiest ways to make money online. Packed with the latest blog tools, tricks, and up-and-coming trends, this fully revised edition teache

  7. Grief: Difficult Times, Simple Steps.

    Science.gov (United States)

    Waszak, Emily Lane

    This guide presents techniques to assist others in coping with the loss of a loved one. Using the language of 9 layperson, the book contains more than 100 tips for caregivers or loved ones. A simple step is presented on each page, followed by reasons and instructions for each step. Chapters include: "What to Say"; "Helpful Things to Do"; "Dealing…

  8. How many steps/day are enough? for adults

    Directory of Open Access Journals (Sweden)

    Rowe David A

    2011-07-01

    Full Text Available Abstract Physical activity guidelines from around the world are typically expressed in terms of frequency, duration, and intensity parameters. Objective monitoring using pedometers and accelerometers offers a new opportunity to measure and communicate physical activity in terms of steps/day. Various step-based versions or translations of physical activity guidelines are emerging, reflecting public interest in such guidance. However, there appears to be a wide discrepancy in the exact values that are being communicated. It makes sense that step-based recommendations should be harmonious with existing evidence-based public health guidelines that recognize that "some physical activity is better than none" while maintaining a focus on time spent in moderate-to-vigorous physical activity (MVPA. Thus, the purpose of this review was to update our existing knowledge of "How many steps/day are enough?", and to inform step-based recommendations consistent with current physical activity guidelines. Normative data indicate that healthy adults typically take between 4,000 and 18,000 steps/day, and that 10,000 steps/day is reasonable for this population, although there are notable "low active populations." Interventions demonstrate incremental increases on the order of 2,000-2,500 steps/day. The results of seven different controlled studies demonstrate that there is a strong relationship between cadence and intensity. Further, despite some inter-individual variation, 100 steps/minute represents a reasonable floor value indicative of moderate intensity walking. Multiplying this cadence by 30 minutes (i.e., typical of a daily recommendation produces a minimum of 3,000 steps that is best used as a heuristic (i.e., guiding value, but these steps must be taken over and above habitual activity levels to be a true expression of free-living steps/day that also includes recommendations for minimal amounts of time in MVPA. Computed steps/day translations of time in

  9. Step Detection Robust against the Dynamics of Smartphones

    Science.gov (United States)

    Lee, Hwan-hee; Choi, Suji; Lee, Myeong-jin

    2015-01-01

    A novel algorithm is proposed for robust step detection irrespective of step mode and device pose in smartphone usage environments. The dynamics of smartphones are decoupled into a peak-valley relationship with adaptive magnitude and temporal thresholds. For extracted peaks and valleys in the magnitude of acceleration, a step is defined as consisting of a peak and its adjacent valley. Adaptive magnitude thresholds consisting of step average and step deviation are applied to suppress pseudo peaks or valleys that mostly occur during the transition among step modes or device poses. Adaptive temporal thresholds are applied to time intervals between peaks or valleys to consider the time-varying pace of human walking or running for the correct selection of peaks or valleys. From the experimental results, it can be seen that the proposed step detection algorithm shows more than 98.6% average accuracy for any combination of step mode and device pose and outperforms state-of-the-art algorithms. PMID:26516857

  10. The impact of didactic read-aloud action cards on the performance of cannula cricothyroidotomy in a simulated 'can't intubate can't oxygenate' scenario.

    Science.gov (United States)

    Harvey, R; Foulds, L; Housden, T; Bennett, K A; Falzon, D; McNarry, A F; Graham, C

    2017-03-01

    Significant benefits have been demonstrated with the use of peri-operative checklists. We assessed whether a read-aloud didactic action card would improve performance of cannula cricothyroidotomy in a simulated 'can't intubate, can't oxygenate' scenario. A 17-step action card was devised by an expert panel. Participants in their first 4 years of anaesthetic training were randomly assigned into 'no-card' or 'card' groups. Scenarios were video-recorded for analysis. Fifty-three participants (27 no-card and 26 card) completed the scenario. The number of steps omitted was mean (SD) 6.7 (2.0) in the no-card group vs. 0.3 (0.5); p < 0.001 in the card group, but the no-card group was faster to oxygenation by mean (95% CI) 35.4 (6.6-64.2) s. The Kappa statistic was 0.84 (0.73-0.95). Our study demonstrated that action cards are beneficial in achieving successful front-of-neck access using a cannula cricothyroidotomy technique. Further investigation is required to determine this tool's effectiveness in other front-of-neck access situations, and its role in teaching or clinical management. © 2016 The Association of Anaesthetists of Great Britain and Ireland.

  11. Corrective Action Investigation Plan for Corrective Action Unit 127: Areas 25 and 26 Storage Tanks, Nevada Test Site, Nevada (Rev. No.: 0, August 2002)

    International Nuclear Information System (INIS)

    NNSA/NV

    2002-01-01

    contaminated materials. Future land-use scenarios limit subsequent uses of the CASs to various nonresidential (i.e., industrial) activities. Field activities will consist of radiological walkover and screening surveys, and field-screening and collecting of both tank content and soil samples, and further sample testing as appropriate. A two-step data quality objective strategy will be followed: (1) Phase I will be to collect environmental samples for laboratory analysis to confirm the presence or absence of contaminants at concentrations exceeding preliminary action levels; and (2) Phase II will be to collect additional environmental samples for laboratory analysis to determine the extent of contamination identified in Phase I. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document

  12. Lateral step initiation behavior in older adults.

    Science.gov (United States)

    Sparto, Patrick J; Jennings, J Richard; Furman, Joseph M; Redfern, Mark S

    2014-02-01

    Older adults have varied postural responses during induced and voluntary lateral stepping. The purpose of the research was to quantify the occurrence of different stepping strategies during lateral step initiation in older adults and to relate the stepping responses to retrospective history of falls. Seventy community-ambulating older adults (mean age 76 y, range 70-94 y) performed voluntary lateral steps as quickly as possible to the right or left in response to a visual cue, in a blocked design. Vertical ground reaction forces were measured using a forceplate, and the number and latency of postural adjustments were quantified. Subjects were assigned to groups based on their stepping strategy. The frequency of trials with one or two postural adjustments was compared with data from 20 younger adults (mean age 38 y, range 21-58 y). Logistic regression was used to relate presence of a fall in the previous year with the number and latency of postural adjustments. In comparison with younger adults, who almost always demonstrated one postural adjustment when stepping laterally, older adults constituted a continuous distribution in the percentage of step trials made with one postural adjustment (from 0% to 100% of trials). Latencies of the initial postural adjustment and foot liftoff varied depending on the number of postural adjustments made. A history of falls was associated a larger percentage of two postural adjustments, and a longer latency of foot liftoff. In conclusion, the number and latency of postural adjustments made during voluntary lateral stepping provides additional evidence that lateral control of posture may be a critical indicator of aging. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. ADDING A NEW STEP WITH SPATIAL AUTOCORRELATION TO IMPROVE THE FOUR-STEP TRAVEL DEMAND MODEL WITH FEEDBACK FOR A DEVELOPING CITY

    Directory of Open Access Journals (Sweden)

    Xuesong FENG, Ph.D Candidate

    2009-01-01

    Full Text Available It is expected that improvement of transport networks could give rise to the change of spatial distributions of population-related factors and car ownership, which are expected to further influence travel demand. To properly reflect such an interdependence mechanism, an aggregate multinomial logit (A-MNL model was firstly applied to represent the spatial distributions of these exogenous variables of the travel demand model by reflecting the influence of transport networks. Next, the spatial autocorrelation analysis is introduced into the log-transformed A-MNL model (called SPA-MNL model. Thereafter, the SPA-MNL model is integrated into the four-step travel demand model with feedback (called 4-STEP model. As a result, an integrated travel demand model is newly developed and named as the SPA-STEP model. Using person trip data collected in Beijing, the performance of the SPA-STEP model is empirically compared with the 4-STEP model. It was proven that the SPA-STEP model is superior to the 4-STEP model in accuracy; most of the estimated parameters showed statistical differences in values. Moreover, though the results of the simulations to the same set of assumed scenarios by the 4-STEP model and the SPA-STEP model consistently suggested the same sustainable path for the future development of Beijing, it was found that the environmental sustainability and the traffic congestion for these scenarios were generally overestimated by the 4-STEP model compared with the corresponding analyses by the SPA-STEP model. Such differences were clearly generated by the introduction of the new modeling step with spatial autocorrelation.

  14. Neuronal interactions between mentalising and action systems during indirect request processing.

    Science.gov (United States)

    van Ackeren, Markus J; Smaragdi, Areti; Rueschemeyer, Shirley-Ann

    2016-09-01

    Human communication relies on the ability to process linguistic structure and to map words and utterances onto our environment. Furthermore, as what we communicate is often not directly encoded in our language (e.g. in the case of irony, jokes or indirect requests), we need to extract additional cues to infer the beliefs and desires of our conversational partners. Although the functional interplay between language and the ability to mentalise has been discussed in theoretical accounts in the past, the neurobiological underpinnings of these dynamics are currently not well understood. Here, we address this issue using functional imaging (fMRI). Participants listened to question-reply dialogues. In these dialogues, a reply is interpreted as a direct reply, an indirect reply or a request for action, depending on the question. We show that inferring meaning from indirect replies engages parts of the mentalising network (mPFC) while requests for action also activate the cortical motor system (IPL). Subsequent connectivity analysis using Dynamic Causal Modelling (DCM) revealed that this pattern of activation is best explained by an increase in effective connectivity from the mentalising network (mPFC) to the action system (IPL). These results are an important step towards a more integrative understanding of the neurobiological basis of indirect speech processing. © The Author (2016). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  15. Ten steps to successful software process improvement

    Science.gov (United States)

    Kandt, R. K.

    2003-01-01

    This paper identifies ten steps for managing change that address organizational and cultural issues. Four of these steps are critical, that if not done, will almost guarantee failure. This ten-step program emphasizes the alignment of business goals, change process goals, and the work performed by the employees of an organization.

  16. Turning Awareness into Action: What Your Community Can Do about Drug Use in America = De La Toma de Conciencia a la Accion: Que Puede Hacer la Comunidad Respecto al Consumo de Drogas en America.

    Science.gov (United States)

    Alcohol, Drug Abuse, and Mental Health Administration (DHHS/PHS), Rockville, MD. Office for Substance Abuse Prevention.

    This booklet gives examples of successful community drug abuse prevention programs, as well as guidelines for finding out more about a community's prevention needs and taking action. The first section discusses taking action against drug abuse. It presents examples which illustrate the different approaches communities have taken. Ten steps to help…

  17. Step-by-step approach to convective cooling of laser disc amplifiers

    International Nuclear Information System (INIS)

    Bourque, R.F.

    1979-04-01

    A step by step approach is presented to the problem of gas cooling of laser glass amplifiers. The basic equations are given for glass conduction, thermal stress, gas convection, and heat exchanger and blower design. An example calculation is then carried out for helium gas at one atmosphere with the gas flow in the direction orthogonal to the optical path. It is found that pumping powers and temperatures are acceptable for this case. Results are also presented for helium in the slant direction and for nitrogen in both directions. Included also are the effects on pumping power of gas temperature rise, gas pressure, flashtube rep rate, and flow channel width. It is found that, based on temperature rise and pumping power, nitrogen is as viable a coolant as helium

  18. Constructing an exposure chart: step by step (based on standard procedures)

    International Nuclear Information System (INIS)

    David, Jocelyn L; Cansino, Percedita T.; Taguibao, Angileo P.

    2000-01-01

    An exposure chart is very important in conducting radiographic inspection of materials. By using an accurate exposure chart, an inspector is able to avoid a trial and error way of determining correct time to expose a specimen, thereby producing a radiograph that has an acceptable density based on a standard. The chart gives the following information: x-ray machine model and brand, distance of the x-ray tube from the film, type and thickness of intensifying screens, film type, radiograph density, and film processing conditions. The methods of preparing an exposure chart are available in existing radiographic testing manuals. These described methods are presented in step by step procedures, covering the actual laboratory set-up, data gathering, computations, and transformation of derived data into Characteristic Curve and Exposure Chart

  19. Considering dominance in reduced single-step genomic evaluations.

    Science.gov (United States)

    Ertl, J; Edel, C; Pimentel, E C G; Emmerling, R; Götz, K-U

    2018-06-01

    Single-step models including dominance can be an enormous computational task and can even be prohibitive for practical application. In this study, we try to answer the question whether a reduced single-step model is able to estimate breeding values of bulls and breeding values, dominance deviations and total genetic values of cows with acceptable quality. Genetic values and phenotypes were simulated (500 repetitions) for a small Fleckvieh pedigree consisting of 371 bulls (180 thereof genotyped) and 553 cows (40 thereof genotyped). This pedigree was virtually extended for 2,407 non-genotyped daughters. Genetic values were estimated with the single-step model and with different reduced single-step models. Including more relatives of genotyped cows in the reduced single-step model resulted in a better agreement of results with the single-step model. Accuracies of genetic values were largest with single-step and smallest with reduced single-step when only the cows genotyped were modelled. The results indicate that a reduced single-step model is suitable to estimate breeding values of bulls and breeding values, dominance deviations and total genetic values of cows with acceptable quality. © 2018 Blackwell Verlag GmbH.

  20. From action planning and plan enactment to fruit consumption: moderated mediation effects.

    Science.gov (United States)

    Kasten, Stefanie; van Osch, Liesbeth; Eggers, Sander Matthijs; de Vries, Hein

    2017-10-23

    . High levels of intention, self-efficacy and a strong habit to consume fruit clearly aid the enactment of action plans. This suggests that when these factors are moderately low, plan enactment may fail and thus an intervention may require first steps to foster these moderating factors.

  1. Stepping movement analysis of control rod drive mechanism

    International Nuclear Information System (INIS)

    Xu Yantao; Zu Hongbiao

    2013-01-01

    Background: Control rod drive mechanism (CRDM) is one of the important safety-related equipment for nuclear power plants. Purpose: The operating parameters of stepping movement, including lifting loads, step distance and step velocity, are all critical design targets. Methods: FEA and numerical simulation are used to analyze stepping movement separately. Results: The motion equations of the movable magnet in stepping movement are established by load analysis. Gravitation, magnetic force, fluid resistance and spring force are all in consideration in the load analysis. The operating parameters of stepping movement are given. Conclusions: The results, including time history curves of force, speed and etc, can positively used in the design of CRDM. (authors)

  2. The portal protein plays essential roles at different steps of the SPP1 DNA packaging process

    International Nuclear Information System (INIS)

    Isidro, Anabela; Henriques, Adriano O.; Tavares, Paulo

    2004-01-01

    A large number of viruses use a specialized portal for entry of DNA to the viral capsid and for its polarized exit at the beginning of infection. These families of viruses assemble an icosahedral procapsid containing a portal protein oligomer in one of its 12 vertices. The viral ATPase (terminase) interacts with the portal vertex to form a powerful molecular motor that translocates DNA to the procapsid interior against a steep concentration gradient. The portal protein is an essential component of this DNA packaging machine. Characterization of single amino acid substitutions in the portal protein gp6 of bacteriophage SPP1 that block DNA packaging identified sequential steps in the packaging mechanism that require its action. Gp6 is essential at early steps of DNA packaging and for DNA translocation to the capsid interior, it affects the efficiency of DNA packaging, it is a central component of the headful sensor that determines the size of the packaged DNA molecule, and is essential for closure of the portal pore by the head completion proteins to prevent exit of the DNA encapsidated. Functional regions of gp6 necessary at each step are identified within its primary structure. The similarity between the architecture of portal oligomers and between the DNA packaging strategies of viruses using portals strongly suggests that the portal protein plays the same roles in a large number of viruses

  3. Impulsive action and motivation

    NARCIS (Netherlands)

    Frijda, N.H.

    2010-01-01

    This paper explores the way in which emotions are causal determinants of action. It argues that emotional events, as appraised by the individual, elicit changes in motive states (called states of action readiness), which in turn may (or may not) cause action. Actions can be elicited automatically,

  4. Steps That Count: Physical Activity Recommendations, Brisk Walking, and Steps Per Minute-How Do They Relate?

    NARCIS (Netherlands)

    Pillay, J.; Kolbe-Alexander, T.L.; Proper, K.I.; van Mechelen, W.; Lambert, E.V.

    2014-01-01

    Background: Brisk walking is recommended as a form of health-enhancing physical activity. This study determines the steps/minute rate corresponding to self-paced brisk walking (SPBW); a predicted steps/minute rate for moderate physical activity (MPA) and a comparison of the 2 findings. Methods: A

  5. Evaluation of one-step luminescent cyanoacrylate fuming.

    Science.gov (United States)

    Khuu, Alicia; Chadwick, Scott; Spindler, Xanthe; Lam, Rolanda; Moret, Sébastien; Roux, Claude

    2016-06-01

    One-step luminescent cyanoacrylates have recently been introduced as an alternative to the conventional cyanoacrylate fuming methods. These new techniques do not require the application of a luminescent post-treatment in order to enhance cyanoacrylate-developed fingermarks. In this study, three one-step polymer cyanoacrylates: CN Yellow Crystals (Aneval Inc.), PolyCyano UV (Foster+Freeman Ltd.) and PECA Multiband (BVDA), and one monomer cyanoacrylate: Lumikit™ (Crime Scene Technology), were evaluated against a conventional two-step cyanoacrylate fuming method (Cyanobloom (Foster+Freeman Ltd.) with rhodamine 6G stain). The manufacturers' recommended conditions or conditions compatible with the MVC™ 1000/D (Foster+Freeman Ltd.) were assessed with fingermarks aged for up to 8 weeks on non-porous and semi-porous substrates. Under white light, Cyanobloom generally gave better development than the one-step treatments across the substrates. Similarly when viewed under the respective luminescent conditions, Cyanobloom with rhodamine 6G stain resulted in improved contrast against the one-step treatments except on polystyrene, where PolyCyano UV and PECA Multiband gave better visualisation. Rhodamine 6G post-treatment of one-step samples did not significantly enhance the contrast of any of the one-step treatments against Cyanobloom/rhodamine 6G-treated samples. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. Linear step drive

    International Nuclear Information System (INIS)

    Haniger, L.; Elger, R.; Kocandrle, L.; Zdebor, J.

    1986-01-01

    A linear step drive is described developed in Czechoslovak-Soviet cooperation and intended for driving WWER-1000 control rods. The functional principle is explained of the motor and the mechanical and electrical parts of the drive, power control, and the indicator of position are described. The motor has latches situated in the reactor at a distance of 3 m from magnetic armatures, it has a low structural height above the reactor cover, which suggests its suitability for seismic localities. Its magnetic circuits use counterpoles; the mechanical shocks at the completion of each step are damped using special design features. The position indicator is of a special design and evaluates motor position within ±1% of total travel. A drive diagram and the flow chart of both the control electronics and the position indicator are presented. (author) 4 figs

  7. 40 CFR 35.917 - Facilities planning (step 1).

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Facilities planning (step 1). 35.917... Facilities planning (step 1). (a) Sections 35.917 through 35.917-9 establish the requirements for facilities... the facilities planning provisions of this subpart before award of step 2 or step 3 grant assistance...

  8. From entrepreneurial intentions to actions: Self-control and action-related doubt, fear, and aversion

    NARCIS (Netherlands)

    Gelderen, van Marco; Kautonen, Teemu; Fink, Matthias

    2015-01-01

    This study draws on the Rubicon model of action phases to study the actions or lack of actions that follow the formation of entrepreneurial intentions. Concurrently, it examines the roles of selfcontrol and action-related emotions in explaining the intention–action gap using longitudinal

  9. Negotiating action

    Science.gov (United States)

    2017-12-01

    After years of working towards a climate accord, the Paris Agreement of 2015 marked the shift from negotiating to reach consensus on climate action to implementation of such action. The challenge now is to ensure transparency in the processes and identify the details of what is required.

  10. Innoversity in knowledge-for-action and adaptation to climate change: the first steps of an 'evidence-based climatic health' transfrontier training program

    Directory of Open Access Journals (Sweden)

    Véronique Lapaige

    2010-12-01

    Full Text Available Véronique Lapaige1–3, Hélène Essiembre41Department of Psychiatry, University of Montreal, Montreal, QC, Canada; 2Fernand-Seguin Research Centre, Montreal, QC, Canada; 3Quebec National Public Health Institute; 4Industrial and Organizational Program, Department of Psychology, University of Montreal, Montreal, QC, CanadaAbstract: It has become increasingly clear to the international scientific community that climate change is real and has important consequences for human health. To meet these new challenges, the World Health Organization recommends reinforcing the adaptive capacity of health systems. One of the possible avenues in this respect is to promote awareness and knowledge translation in climatic health, at both the local and global scales. Within such perspective, two major themes have emerged in the field of public health research: 1 the development of advanced training adapted to 'global environment' change and to the specific needs of various groups of actors (doctors, nurses, public health practitioners, health care managers, public service managers, local communities, etc and 2 the development of strategies for implementing research results and applying various types of evidence to the management of public health issues affected by climate change. Progress on these two fronts will depend on maximum innovation in transdisciplinary and transsectoral collaborations. The general purpose of this article is to present the program of a new research and learning chair designed for this double set of developmental objectives – a chair that emphasizes 'innoversity' (the dynamic relationship between innovation and diversity and 'transfrontier ecolearning for adaptive actions'. The Écoapprentissages, santé mentale et climat collaborative research chair (University of Montreal and Quebec National Public Health Institute based in Montreal is a center for 'transdisciplinary research' on the transfrontier knowledge-for-action that can aid

  11. Actions and Decisions

    DEFF Research Database (Denmark)

    Monthoux, Pierre Guillet de

    2017-01-01

    as Aristotelian syllogistic reasoning. Her constant analytical care to defend a philosophy of action against metaphysical assumptions and taken-for-granted “psychologisms” shows that an action-perspective is as analytic as ever one of decision-making. What differs is that the latter seems constantly attracted......How management philosophy is conceived depends on if pragmatism is acknowledged or not! After having been under the main domination of management science both research and education has until recently widened its scope from a decision-making to an action-perspective. It seems to be a recent...... reconnection to pragmatism that makes the 2011 Carnegie report propose to rethink management in liberal arts terms, whilst the vastly influential 1959 Carnegie Pierson report distanced itself from American pragmatism thus focusing on decisions and forgetting actions. Actions may contain decisions and choices...

  12. Women In Action: Challenges Facing Women Entrepreneurs In The Gauteng Province Of South Africa

    OpenAIRE

    Elizabeth Chinomona; Eugine Tafadzwa Maziriri

    2015-01-01

    In today’s post-modern era, the role of women entrepreneurs in economic development is inevitable and women are willing to take action in business and contribute to the nation’s growth. Women are stepping up to own and run businesses in numbers that would have been hard to imagine a mere few decades ago. However, women entrepreneurs face a wide variety of challenges both in starting and in growing their business ventures. The objective of this paper is to investigate the challenges women entr...

  13. Focal cryotherapy: step by step technique description

    Directory of Open Access Journals (Sweden)

    Cristina Redondo

    Full Text Available ABSTRACT Introduction and objective: Focal cryotherapy emerged as an efficient option to treat favorable and localized prostate cancer (PCa. The purpose of this video is to describe the procedure step by step. Materials and methods: We present the case of a 68 year-old man with localized PCa in the anterior aspect of the prostate. Results: The procedure is performed under general anesthesia, with the patient in lithotomy position. Briefly, the equipment utilized includes the cryotherapy console coupled with an ultrasound system, argon and helium gas bottles, cryoprobes, temperature probes and an urethral warming catheter. The procedure starts with a real-time trans-rectal prostate ultrasound, which is used to outline the prostate, the urethra and the rectal wall. The cryoprobes are pretested and placed in to the prostate through the perineum, following a grid template, along with the temperature sensors under ultrasound guidance. A cystoscopy confirms the right positioning of the needles and the urethral warming catheter is installed. Thereafter, the freeze sequence with argon gas is started, achieving extremely low temperatures (-40°C to induce tumor cell lysis. Sequentially, the thawing cycle is performed using helium gas. This process is repeated one time. Results among several series showed a biochemical disease-free survival between 71-93% at 9-70 month- follow-up, incontinence rates between 0-3.6% and erectile dysfunction between 0-42% (1–5. Conclusions: Focal cryotherapy is a feasible procedure to treat anterior PCa that may offer minimal morbidity, allowing good cancer control and better functional outcomes when compared to whole-gland treatment.

  14. 40 CFR 35.2109 - Step 2+3.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Step 2+3. 35.2109 Section 35.2109... ASSISTANCE Grants for Construction of Treatment Works § 35.2109 Step 2+3. The Regional Administrator may award a Step 2+3 grant which will provide the Federal share of an allowance under appendix B and the...

  15. The Action Observation System when Observing Hand Actions in Autism and Typical Development.

    Science.gov (United States)

    Pokorny, Jennifer J; Hatt, Naomi V; Colombi, Costanza; Vivanti, Giacomo; Rogers, Sally J; Rivera, Susan M

    2015-06-01

    Social impairments in individuals with autism spectrum disorders (ASD) may be in part due to difficulty perceiving and recognizing the actions of others. Evidence from imitation studies, which involves both observation and execution of an action, suggests differences, in individuals with ASD, between the ability to imitate goal-directed actions involving objects (transitive actions) and the ability to imitate actions that do not involve objects (intransitive actions). In the present study, we examined whether there were differences in how ASD adolescents encoded transitive and intransitive actions compared to typically developing (TD) adolescents, by having participants view videos of a hand reaching across a screen toward an object or to where an object would be while functional magnetic resonance images were collected. Analyses focused on areas within the action observation network (AON), which is activated during the observation of actions performed by others. We hypothesized that the AON would differentiate transitive from intransitive actions only in the ASD group. However, results revealed that object presence modulated activity in the right inferior frontal gyrus and supramarginal gyrus of the TD group, a differentiation that was not seen in the ASD group. Furthermore, there were no significant group differences between the TD and ASD groups in any of the conditions. This suggests that there is not a global deficit of the AON in individuals with ASD while observing transitive and intransitive actions. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

  16. Enforcement actions: Significant actions resolved individuals actions. Semiannual progress report, July--December 1996

    International Nuclear Information System (INIS)

    1997-04-01

    This compilation summarizes significant enforcement actions that have been resolved during the period (July - December 1996) and includes copies of Orders and Notices of Violation sent by the Nuclear Regulatory Commission to individuals with respect to-these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC. The Commission believes this information may be useful to licensees in making employment decisions

  17. Enforcement actions: Significant actions resolved individuals actions. Semiannual progress report, July--December 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    This compilation summarizes significant enforcement actions that have been resolved during the period (July - December 1996) and includes copies of Orders and Notices of Violation sent by the Nuclear Regulatory Commission to individuals with respect to-these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC. The Commission believes this information may be useful to licensees in making employment decisions.

  18. Self-benchmarking Guide for Cleanrooms: Metrics, Benchmarks, Actions

    Energy Technology Data Exchange (ETDEWEB)

    Mathew, Paul; Sartor, Dale; Tschudi, William

    2009-07-13

    This guide describes energy efficiency metrics and benchmarks that can be used to track the performance of and identify potential opportunities to reduce energy use in laboratory buildings. This guide is primarily intended for personnel who have responsibility for managing energy use in existing laboratory facilities - including facilities managers, energy managers, and their engineering consultants. Additionally, laboratory planners and designers may also use the metrics and benchmarks described in this guide for goal-setting in new construction or major renovation. This guide provides the following information: (1) A step-by-step outline of the benchmarking process. (2) A set of performance metrics for the whole building as well as individual systems. For each metric, the guide provides a definition, performance benchmarks, and potential actions that can be inferred from evaluating this metric. (3) A list and descriptions of the data required for computing the metrics. This guide is complemented by spreadsheet templates for data collection and for computing the benchmarking metrics. This guide builds on prior research supported by the national Laboratories for the 21st Century (Labs21) program, supported by the U.S. Department of Energy and the U.S. Environmental Protection Agency. Much of the benchmarking data are drawn from the Labs21 benchmarking database and technical guides. Additional benchmark data were obtained from engineering experts including laboratory designers and energy managers.

  19. Body posture modulates action perception.

    Science.gov (United States)

    Zimmermann, Marius; Toni, Ivan; de Lange, Floris P

    2013-04-03

    Recent studies have highlighted cognitive and neural similarities between planning and perceiving actions. Given that action planning involves a simulation of potential action plans that depends on the actor's body posture, we reasoned that perceiving actions may also be influenced by one's body posture. Here, we test whether and how this influence occurs by measuring behavioral and cerebral (fMRI) responses in human participants predicting goals of observed actions, while manipulating postural congruency between their own body posture and postures of the observed agents. Behaviorally, predicting action goals is facilitated when the body posture of the observer matches the posture achieved by the observed agent at the end of his action (action's goal posture). Cerebrally, this perceptual postural congruency effect modulates activity in a portion of the left intraparietal sulcus that has previously been shown to be involved in updating neural representations of one's own limb posture during action planning. This intraparietal area showed stronger responses when the goal posture of the observed action did not match the current body posture of the observer. These results add two novel elements to the notion that perceiving actions relies on the same predictive mechanism as planning actions. First, the predictions implemented by this mechanism are based on the current physical configuration of the body. Second, during both action planning and action observation, these predictions pertain to the goal state of the action.

  20. The Effects of Action Potential Stimulation on Pain, Swelling and Function of Patients with Knee Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Razieh Sepehri

    2012-06-01

    Full Text Available Background: Knee osteoarthritis (OA is one of the most prevalent joint diseases. Electrical muscle stimulation is effective to improve its symptoms. Today, action potential stimulation (APS with various currents and periods is used to treat OA. This study aims at analyzing the effect of action potential stimulation in improving knee OA symptoms. Materials and Methods: In this clinical trial, patients with mild to moderate knee OA divided randomly in two groups each had 15 people. Along with the conventional exercises of physiotherapy, one group received 16 minutes action potential stimulation with the lowest intensity (sensible; but the other group besides receiving the conventional exercises of physiotherapy was connected into a plugged off machine for 16 minutes. Certain variables were measured and recorded four times. Results: Comparing the variables before and after intervention did not show any meaningful difference between the two groups. But within group, pain with p=0.0001 showed a meaningful decrease. Decreasing of swelling (inflammation in group 1 and 2 was meaningful with p<0.001 and p<0.001, respectively. For group 1, knee flexion range was improved meaningfully between first and fourth times as p<0.031, but it was not meaningful for group 2. Duration of 50 meters walking and step up and down from three steps significantly decreased in both groups. Conclusion: Although there was no significant difference in variables between two groups, but within both groups’ pain and swelling decreased and functional ability increased, thus, it can be concluded that type of APS does not play a key role in treating knee OA.

  1. Historiografia wobec Action Francaise

    Directory of Open Access Journals (Sweden)

    Marek Kornat

    2009-06-01

    Full Text Available Action Franęaise in HistoriographyFrench radical right movement, Action Franęaise belongs to those political phe- nomenon in history which are differently interpreted by historiography. Principally we have eight interpretations. First ofthem is Action Franęaise own image and identity as royalist and anti-liberal "party of order”. One of the most important historical interpretation of this movement is French historian Rene Remond’s one. In his Les Droites aujourdhui Remond argued that Action Franęaise was model example of anti-liberal Right in France and in Europe of the first half of the XX century. The most popular interpretation of Action Franęaise are two: (1 Action Franęaise as an incarnation of conservative revolution (Carl Schmitt and (2 as the ideology of "integral nationalism” (Hans Konh, Carlton Hayes. Very original concept was developed by well known German historian Ernst Nolte, who considered Action Franęaise as pro- to-fascistmovement. British thinker Isaiah Berlin and Israeli historian Zeev Sternhell interpreted Action Franęaise as revolution of "anti-Enlightment” (les anti-Lumieres. Polish philosopher Stanisław Brzozowski argued that Action Franęaise was a con- seąuence of conflict between romanticism and positivism and was sure that Action Franęaise inherited much from positivistphilosophy. Non less controversial problem is forthehistorians the excommunication of Action Franęaise by Pope Pius XI in 1926. To our days there are many opposite attempts to reconstruct of this event and its origins. For many historians Pius XI tried to defend the doctrine of the Church which seemed to him intoxicated by the "nationalist and racialist heresy”. For some other writers the Vatican policy was under German influence and this caused papai action. In 1939 another Pope Pius XII decided to abolish the condemnation from 1926.

  2. Nurses in action: An introduction to action research in nursing

    Directory of Open Access Journals (Sweden)

    E. C. McKibbin

    1996-03-01

    Full Text Available Action Research is one of the new generation of qualitative research methods in the social sciences which has special significance for nurses in South Africa. The collaborative, participative and reflective qualities of Action Research appeal to practitioners, and lend themselves to joint problem solving activities in local contexts. This paper sets out a rationale for Action Research, then describes its features, strengths, and limitations. Ways of overcoming the latter are suggested. The paper concludes that Action Research has potential application in the field of nursing, not only for the purposes of practical problem solving, but also for improving the personal and professional practice of nurses, and for emancipating nurses from their subordinate position in the hierarchy of health science.

  3. Action Intentions: Action Influences Both On-Line Perception and Off-Line Representation

    Directory of Open Access Journals (Sweden)

    C Kirtley

    2014-08-01

    Full Text Available Given that one role of vision is to gather information for upcoming tasks, previous studies have investigated whether the preparation for action affects visual behaviour. The current studies aimed to determine if such influences on visual selection would also influence the formation of subsequent memory representations. Two experiments were conducted- in the first, participants' action intentions towards a scene were manipulated by the performance of different grasping postures as they observed the scene. This was followed by a memory test for the objects presented. Participants' eye movements were affected by their action intention, so that performing a power grip led to significantly longer fixation durations on power grip compatible objects. In contrast, memory for the objects and their properties was not affected by the action. Our second study required participants to make the action posture during the recall phase. No effect on eye movements was found, but recall was affected, with a particular advantage for recall of the position of grip-compatible objects. Previous studies have shown that action intentions can affect the on-line perception of objects. The current study suggests this may not extend to off-line representations if they are accessed after the action has been completed or abandoned. However, the recall of information may be affected if gestures are formed during retrieval. Memory representations may not be tailored specifically to an action, but actions can still affect the recall of information.

  4. Tracking Steps on Apple Watch at Different Walking Speeds.

    Science.gov (United States)

    Veerabhadrappa, Praveen; Moran, Matthew Duffy; Renninger, Mitchell D; Rhudy, Matthew B; Dreisbach, Scott B; Gift, Kristin M

    2018-04-09

    QUESTION: How accurate are the step counts obtained from Apple Watch? In this validation study, video steps vs. Apple Watch steps (mean ± SD) were 2965 ± 144 vs. 2964 ± 145 steps; P Apple Watch steps when compared with the manual counts obtained from video recordings. Our study is one of the initial studies to objectively validate the accuracy of the step counts obtained from Apple watch at different walking speeds. Apple Watch tested to be an extremely accurate device for measuring daily step counts for adults.

  5. The Prose of Action

    DEFF Research Database (Denmark)

    Christiansen, Ulrik; Thrane, Sof

    2014-01-01

    risks changes over time in response to a lack of action on reported risks. In these processes Frontline Managers take on new responsibilities to make General Managers take action on reported risk. The reporting practice changes from the mere identification of risk to risk assessment and, finally......, to incorporating the possible response into the risk report. These findings add to extant literature by illustrating that actions do not automatically flow from the identification of risk. Rather, risk and action are dynamically interrelated in the sense that the prose in the risk report is a variable input...... to generate action and that a lack of action encourages managers to change their approach to reporting....

  6. Action research: Scandinavian Experiences

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard

    2004-01-01

    The article focus on paradigms, methods and ethics of action research in the Scandinavian countries. The special features of the action research paradigm is identified. A historical overview follows of some main action research projects in Norway, Sweden and Denmark. The tendency towards upsclae...... action research projects from organisational or small community projects yo large-scale, regional based network apporaches are also outlined and discussed. Finally, a synthesised approach of the classical, socio-technical action research approach and the large-scale network and holistic approaches...

  7. Joint action modulates motor system involvement during action observation in 3-year-olds

    NARCIS (Netherlands)

    Meyer, M.; Hunnius, S.; Elk, M. van; Ede, F.L. van; Bekkering, H.

    2011-01-01

    When we are engaged in a joint action, we need to integrate our partner's actions with our own actions. Previous research has shown that in adults the involvement of one's own motor system is enhanced during observation of an action partner as compared to during observation of an individual actor.

  8. Learning Sequences of Actions in Collectives of Autonomous Agents

    Science.gov (United States)

    Turner, Kagan; Agogino, Adrian K.; Wolpert, David H.; Clancy, Daniel (Technical Monitor)

    2001-01-01

    In this paper we focus on the problem of designing a collective of autonomous agents that individually learn sequences of actions such that the resultant sequence of joint actions achieves a predetermined global objective. We are particularly interested in instances of this problem where centralized control is either impossible or impractical. For single agent systems in similar domains, machine learning methods (e.g., reinforcement learners) have been successfully used. However, applying such solutions directly to multi-agent systems often proves problematic, as agents may work at cross-purposes, or have difficulty in evaluating their contribution to achievement of the global objective, or both. Accordingly, the crucial design step in multiagent systems centers on determining the private objectives of each agent so that as the agents strive for those objectives, the system reaches a good global solution. In this work we consider a version of this problem involving multiple autonomous agents in a grid world. We use concepts from collective intelligence to design goals for the agents that are 'aligned' with the global goal, and are 'learnable' in that agents can readily see how their behavior affects their utility. We show that reinforcement learning agents using those goals outperform both 'natural' extensions of single agent algorithms and global reinforcement, learning solutions based on 'team games'.

  9. Step by step. How to install CopperCore, how to publish and run a UoL

    NARCIS (Netherlands)

    Burgos, Daniel

    2005-01-01

    Through these four documents the full installation process of CopperCore is described in detailed. Step by step, and full supported with screenshots, it's shown how to install Cc, how to publish a UoL with Cc and Clicc, how to run a UoL and to exit of Cc and Clicc

  10. Stereoscopically Observing Manipulative Actions.

    Science.gov (United States)

    Ferri, S; Pauwels, K; Rizzolatti, G; Orban, G A

    2016-08-01

    The purpose of this study was to investigate the contribution of stereopsis to the processing of observed manipulative actions. To this end, we first combined the factors "stimulus type" (action, static control, and dynamic control), "stereopsis" (present, absent) and "viewpoint" (frontal, lateral) into a single design. Four sites in premotor, retro-insular (2) and parietal cortex operated specifically when actions were viewed stereoscopically and frontally. A second experiment clarified that the stereo-action-specific regions were driven by actions moving out of the frontoparallel plane, an effect amplified by frontal viewing in premotor cortex. Analysis of single voxels and their discriminatory power showed that the representation of action in the stereo-action-specific areas was more accurate when stereopsis was active. Further analyses showed that the 4 stereo-action-specific sites form a closed network converging onto the premotor node, which connects to parietal and occipitotemporal regions outside the network. Several of the specific sites are known to process vestibular signals, suggesting that the network combines observed actions in peripersonal space with gravitational signals. These findings have wider implications for the function of premotor cortex and the role of stereopsis in human behavior. © The Author 2016. Published by Oxford University Press.

  11. Step-by-step manual for planning and performing bifurcation PCI: a resource-tailored approach.

    Science.gov (United States)

    Milasinovic, Dejan; Wijns, William; Ntsekhe, Mpiko; Hellig, Farrel; Mohamed, Awad; Stankovic, Goran

    2018-02-02

    As bifurcation PCI can often be resource-demanding due to the use of multiple guidewires, balloons and stents, different technical options are sometimes being explored, in different local settings, to meet the need of optimally treating a patient with a bifurcation lesion, while being confronted with limited material resources. Therefore, it seems important to keep a proper balance between what is recognised as the contemporary state of the art, and what is known to be potentially harmful and to be discouraged. Ultimately, the resource-tailored approach to bifurcation PCI may be characterised by the notion of minimum technical requirements for each step of a successful procedure. Hence, this paper describes the logical sequence of steps when performing bifurcation PCI with provisional SB stenting, starting with basic anatomy assessment and ending with the optimisation of MB stenting and the evaluation of the potential need to stent the SB, suggesting, for each step, the minimum technical requirement for a successful intervention.

  12. One-step fabrication of multifunctional micromotors

    Science.gov (United States)

    Gao, Wenlong; Liu, Mei; Liu, Limei; Zhang, Hui; Dong, Bin; Li, Christopher Y.

    2015-08-01

    Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsification and solidification, a sphere-shaped, asymmetric, and multifunctional micromotor is formed. Some of the attractive functions of this model micromotor include autonomous movement in high ionic strength solution, remote control, enzymatic disassembly and sustained release. This one-step, versatile fabrication method can be easily scaled up and therefore may have great potential in mass production of multifunctional micromotors for a wide range of practical applications.Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsification and solidification, a sphere-shaped, asymmetric, and multifunctional micromotor is formed. Some of the attractive functions of this model micromotor include autonomous movement in high ionic strength solution, remote control, enzymatic disassembly and sustained release. This one-step, versatile fabrication method can be easily scaled up and therefore may have great potential in mass production of multifunctional micromotors for a wide range of practical applications. Electronic supplementary information (ESI) available: Videos S1-S4 and Fig. S1-S3. See DOI: 10.1039/c5nr03574k

  13. Innoversity in knowledge-for-action and adaptation to climate change: the first steps of an 'evidence-based climatic health' transfrontier training program.

    Science.gov (United States)

    Lapaige, Véronique; Essiembre, Hélène

    2010-01-01

    It has become increasingly clear to the international scientific community that climate change is real and has important consequences for human health. To meet these new challenges, the World Health Organization recommends reinforcing the adaptive capacity of health systems. One of the possible avenues in this respect is to promote awareness and knowledge translation in climatic health, at both the local and global scales. Within such perspective, two major themes have emerged in the field of public health research: 1) the development of advanced training adapted to 'global environment' change and to the specific needs of various groups of actors (doctors, nurses, public health practitioners, health care managers, public service managers, local communities, etc) and 2) the development of strategies for implementing research results and applying various types of evidence to the management of public health issues affected by climate change. Progress on these two fronts will depend on maximum innovation in transdisciplinary and transsectoral collaborations. The general purpose of this article is to present the program of a new research and learning chair designed for this double set of developmental objectives - a chair that emphasizes 'innoversity' (the dynamic relationship between innovation and diversity) and 'transfrontier ecolearning for adaptive actions'. The Écoapprentissages, santé mentale et climat collaborative research chair (University of Montreal and Quebec National Public Health Institute) based in Montreal is a center for 'transdisciplinary research' on the transfrontier knowledge-for-action that can aid adaptation of the public health sector, the public mental health sector, and the public service sector to climate change, as well as a center for complex collaborations on evidence-based climatic health 'training'. This program-focused article comprises two main sections. The first section presents the 'general' and 'specific contexts' in which the

  14. Lack of motor prediction, rather than perceptual conflict, evokes an odd sensation upon stepping onto a stopped escalator

    Science.gov (United States)

    Gomi, Hiroaki; Sakurada, Takeshi; Fukui, Takao

    2014-01-01

    When stepping onto a stopped escalator, we often perceive an “odd sensation” that is never felt when stepping onto stairs. The sight of an escalator provides a strong contextual cue that, in expectation of the backward acceleration when stepping on, triggers an anticipatory forward postural adjustment driven by a habitual and implicit motor process. Here we contrast two theories about why this postural change leads to an odd sensation. The first theory links the odd sensation to a lack of sensorimotor prediction from all low-level implicit motor processes. The second theory links the odd sensation to the high-level conflict between the conscious awareness that the escalator is stopped and the implicit perception that evokes an endogenous motor program specific to a moving escalator. We show very similar postural changes can also arise from reflexive responses to visual stimuli, such as contracting/expanding optic flow fields, and that these reflexive responses produce similar odd sensations to the stopped escalator. We conclude that the high-level conflict is not necessary for such sensations. In contrast, the implicitly driven behavioral change itself essentially leads to the odd sensation in motor perception since the unintentional change may be less attributable to self-generated action because of a lack of motor predictions. PMID:24688460

  15. Rapid transformation of two libraries using Kotter's Eight Steps of Change.

    Science.gov (United States)

    Wheeler, Terrie R; Holmes, Kristi L

    2017-07-01

    Two new directors were each charged by their institutions to catalyze transformational change in their libraries and to develop dynamic and evolving information ecosystems ready for the information challenges of the future. The directors approached this transformational change using a strategic, forward-looking approach. This paper presents examples of actions that served as catalysts for change at the two libraries using Kotter's Eight Steps of Change as a framework. Small and large changes are critical for successfully transforming library services, resources, and personnel. Libraries are faced with incredible pressure to adapt to meet emerging and intensifying information needs on today's academic medical campuses. These pressures offer an opportunity for libraries to accelerate their evolution at the micro and macro levels. This commentary reports the expansion of new services and areas of support, enhancement of professional visibility of the libraries on their campuses, and overall, a more positive and productive environment at the respective institutions.

  16. Stepping in Place While Voluntarily Turning Around Produces a Long-Lasting Posteffect Consisting in Inadvertent Turning While Stepping Eyes Closed

    Directory of Open Access Journals (Sweden)

    Stefania Sozzi

    2016-01-01

    Full Text Available Training subjects to step in place on a rotating platform while maintaining a fixed body orientation in space produces a posteffect consisting in inadvertent turning around while stepping in place eyes closed (podokinetic after-rotation, PKAR. We tested the hypothesis that voluntary turning around while stepping in place also produces a posteffect similar to PKAR. Sixteen subjects performed 12 min of voluntary turning while stepping around their vertical axis eyes closed and 12 min of stepping in place eyes open on the center of a platform rotating at 60°/s (pretests. Then, subjects continued stepping in place eyes closed for at least 10 min (posteffect. We recorded the positions of markers fixed to head, shoulder, and feet. The posteffect of voluntary turning shared all features of PKAR. Time decay of angular velocity, stepping cadence, head acceleration, and ratio of angular velocity after to angular velocity before were similar between both protocols. Both postrotations took place inadvertently. The posteffects are possibly dependent on the repeated voluntary contraction of leg and foot intrarotating pelvic muscles that rotate the trunk over the stance foot, a synergy common to both protocols. We propose that stepping in place and voluntary turning can be a scheme ancillary to the rotating platform for training body segment coordination in patients with impairment of turning synergies of various origin.

  17. Albertans and Climate Change, taking action : key actions to date

    International Nuclear Information System (INIS)

    2004-03-01

    In October 2002, Alberta Environment released Canada's first government action plan that addresses climate change and reduces greenhouse gases. This document outlines the progress that Alberta has made since the launch of the action plan entitled Albertans and Climate Change, taking action. The document highlights 32 key actions involving government leadership, technology and innovation, carbon management, energy conservation, renewable and alternative energy, carbon storage in agricultural and forestry sinks, and adaptation to climate change. Among the initiatives is a green power contract signed by the Government of Alberta which states that by 2005, 90 per cent of the electricity used in provincial government operations will come from green power sources. Investment into clean coal technology, fuel cell technology and combined greenhouse heat and power technology was also highlighted

  18. Evolution of robot-assisted orthotopic ileal neobladder formation: a step-by-step update to the University of Southern California (USC) technique.

    Science.gov (United States)

    Chopra, Sameer; de Castro Abreu, Andre Luis; Berger, Andre K; Sehgal, Shuchi; Gill, Inderbir; Aron, Monish; Desai, Mihir M

    2017-01-01

    To describe our, step-by-step, technique for robotic intracorporeal neobladder formation. The main surgical steps to forming the intracorporeal orthotopic ileal neobladder are: isolation of 65 cm of small bowel; small bowel anastomosis; bowel detubularisation; suture of the posterior wall of the neobladder; neobladder-urethral anastomosis and cross folding of the pouch; and uretero-enteral anastomosis. Improvements have been made to these steps to enhance time efficiency without compromising neobladder configuration. Our technical improvements have resulted in an improvement in operative time from 450 to 360 min. We describe an updated step-by-step technique of robot-assisted intracorporeal orthotopic ileal neobladder formation. © 2016 The Authors BJU International © 2016 BJU International Published by John Wiley & Sons Ltd.

  19. 'Action 2016': AREVA's strategic action plan to improve performance

    International Nuclear Information System (INIS)

    Marie, Patricia; Floquet-Daubigeon, Fleur; Michaut, Maxime; De Scorbiac, Marie; Du Repaire, Philippine

    2011-01-01

    On December 12, 2011, Luc Oursel, Executive Officer of AREVA, and Pierre Aubouin, Chief Financial Executive Officer, presented the group's 'Action 2016' strategic action plan based on an in-depth analysis of the market's outlook. This document makes, first, a Detailed presentation of the 'Action 2016' plan and then presents the group's financial outlook: - Full-year 2011 immediate accounting consequences of the new market environment: operating losses expected in 2011; - 2012-2013 transition period Objective: self-finance capex in cumulative terms; - 2014-2016: safe growth and cash generation, free operating cash flow at break-even beginning in 2013, above euro 1 bn per year beginning in 2015

  20. RCRA corrective action ampersand CERCLA remedial action reference guide

    International Nuclear Information System (INIS)

    1994-07-01

    This reference guide provides a side-by-side comparison of RCRA corrective action and CERCLA Remedial Action, focusing on the statutory and regulatory requirements under each program, criterial and other factors that govern a site's progress, and the ways in which authorities or requirements under each program overlap and/or differ. Topics include the following: Intent of regulation; administration; types of sites and/or facilities; definition of site and/or facility; constituents of concern; exclusions; provisions for short-term remedies; triggers for initial site investigation; short term response actions; site investigations; remedial investigations; remedial alternatives; clean up criterial; final remedy; implementing remedy; on-site waste management; completion of remedial process

  1. Subliminal action priming modulates the perceived intensity of sensory action consequences☆

    Science.gov (United States)

    Stenner, Max-Philipp; Bauer, Markus; Sidarus, Nura; Heinze, Hans-Jochen; Haggard, Patrick; Dolan, Raymond J.

    2014-01-01

    The sense of control over the consequences of one’s actions depends on predictions about these consequences. According to an influential computational model, consistency between predicted and observed action consequences attenuates perceived stimulus intensity, which might provide a marker of agentic control. An important assumption of this model is that these predictions are generated within the motor system. However, previous studies of sensory attenuation have typically confounded motor-specific perceptual modulation with perceptual effects of stimulus predictability that are not specific to motor action. As a result, these studies cannot unambiguously attribute sensory attenuation to a motor locus. We present a psychophysical experiment on auditory attenuation that avoids this pitfall. Subliminal masked priming of motor actions with compatible prime–target pairs has previously been shown to modulate both reaction times and the explicit feeling of control over action consequences. Here, we demonstrate reduced perceived loudness of tones caused by compatibly primed actions. Importantly, this modulation results from a manipulation of motor processing and is not confounded by stimulus predictability. We discuss our results with respect to theoretical models of the mechanisms underlying sensory attenuation and subliminal motor priming. PMID:24333539

  2. Statistical theory of multi-step compound and direct reactions

    International Nuclear Information System (INIS)

    Feshbach, H.; Kerman, A.; Koonin, S.

    1980-01-01

    The theory of nuclear reactions is extended so as to include a statistical treatment of multi-step processes. Two types are distinguished, the multi-step compound and the multi-step direct. The wave functions for the system are grouped according to their complexity. The multi-step direct process involves explicitly those states which are open, while the multi-step compound involves those which are bound. In addition to the random phase assumption which is applied differently to the multi-step direct and to the multi-step compound cross-sections, it is assumed that the residual interaction will have non-vanishing matrix elements between states whose complexities differ by at most one unit. This is referred to as the chaining hypothesis. Explicit expressions for the double differential cross-section giving the angular distribution and energy spectrum are obtained for both reaction types. The statistical multi-step compound cross-sections are symmetric about 90 0 . The classical statistical theory of nuclear reactions is a special limiting case. The cross-section for the statistical multi-step direct reaction consists of a set of convolutions of single-step direct cross-sections. For the many step case it is possible to derive a diffusion equation in momentum space. Application is made to the reaction 181 Ta(p,n) 181 W using the statistical multi-step compound formalism

  3. A Control Law Definition of the Open Loop Stepping Electric Drive

    Directory of Open Access Journals (Sweden)

    A. B. Krasovskii

    2015-01-01

    Full Text Available The paper considers an open loop stepping electric drive (SEP with electric crushing of a step and motor fed from the controlled current invertor which should meet the requirement that is to trial a free-form guided trajectory with a split-hair accuracy. It is shown that with traditional programmed control, when the SEP forms motor phase currents of identical amplitude and variable frequency proportional to the set speed of movement, there may be considerable errors reducing a trial accuracy of the set movement trajectory, dynamic indicators provoking oscillatory processes, and even loss of motor synchronism because influence on a dynamic moment of the motor is impossible.The paper offers and proves a new way to define a control algorithm adequate to drive parameters and programmed trajectory of movement, providing error minimization and thereby increasing trial accuracy of set parameters of movement and expanding dynamic capabilities of a drive. The essence of the offered way is to use a modified mathematical model of a drive in d,q coordinates with a motor fed by the current source. In this model a programmed trajectory of movement is chosen as an input action while solving the appropriate equations defines the necessary law of control. The paper describes a developed simulation model of the stepping electric drive in the environment of MATLAB – SIMULINK, which has been used to verify and prove an efficiency of the offered method to define a control law via typical examples.It is established that no error trial of set movement trajectory in case it has breaks (jogs is technically unfeasible, as it demands an infinitely high forcing voltage of the power supply to maintain the instant positive or negative phase shifts of currents formed in the motor windings.The obtained results can be used in designing programmable precision SEPs in robots, numerically controlled machine tools, and assembly equipment.

  4. Multidisciplinary and multisectoral coalitions as catalysts for action against antimicrobial resistance: Implementation experiences at national and regional levels.

    Science.gov (United States)

    Joshi, Mohan P; Chintu, Chifumbe; Mpundu, Mirfin; Kibuule, Dan; Hazemba, Oliver; Andualem, Tenaw; Embrey, Martha; Phulu, Bayobuya; Gerba, Heran

    2018-03-20

    The multi-faceted complexities of antimicrobial resistance (AMR) require consistent action, a multidisciplinary approach, and long-term political commitment. Building coalitions can amplify stakeholder efforts to carry out effective AMR prevention and control strategies. We have developed and implemented an approach to help local stakeholders kick-start the coalition-building process. The five-step process is to (1) mobilise support, (2) understand the local situation, (3) develop an action plan, (4) implement the plan, and (5) monitor and evaluate. We first piloted the approach in Zambia in 2004, then used the lessons learned to expand it for use in Ethiopia and Namibia and to the regional level through the Ecumenical Pharmaceutical Network [EPN]. Call-to-action declarations and workshops helped promote a shared vision, resulting in the development of national AMR action plans, revision of university curricula to incorporate relevant topics, infection control activities, engagement with journalists from various mass media outlets, and strengthening of drug quality assurance systems. Our experience with the coalition-building approach in Ethiopia, Namibia, Zambia, and with the EPN shows that coalitions can form in a variety of ways with many different stakeholders, including government, academia, and faith-based organisations, to organise actions to preserve the effectiveness of existing antimicrobials and contain AMR.

  5. Thermal fatigue in mixing tees: A step by step simplified procedure

    International Nuclear Information System (INIS)

    Faidy, Claude

    2003-01-01

    Following the CIVAUX 1 incident of a leak on RHR system, EDF has developed a step by step procedure to screen and analyse similar locations: mixing tees with long duration at high ΔT between the 2 fluids. The paper present the procedure, the background of the methodology and few R and D work that support this procedure. The procedure is based on: screening criteria on maximum DT and minimum duration. screening criteria without any duration consideration, only DT and material. a simplified and conservative estimation of a usage factor. a detailed analysis of usage factor and crack growth rate, based on specific data collection of operating transients. Around that procedure EDF launched an R and D program on fatigue curves and fatigue reduction factors for high cycle fatigue. The procedure is compared with field experience and recent R and D fatigue tests. (author)

  6. Compliant walking appears metabolically advantageous at extreme step lengths.

    Science.gov (United States)

    Kim, Jaehoon; Bertram, John E A

    2018-05-19

    Humans alter gait in response to unusual gait circumstances to accomplish the task of walking. For instance, subjects spontaneously increase leg compliance at a step length threshold as step length increases. Here we test the hypothesis that this transition occurs based on the level of energy expenditure, where compliant walking becomes less energetically demanding at long step lengths. To map and compare the metabolic cost of normal and compliant walking as step length increases. 10 healthy individuals walked on a treadmill using progressively increasing step lengths (100%, 120%, 140% and 160% of preferred step length), in both normal and compliant leg walking as energy expenditure was recorded via indirect calorimetry. Leg compliance was controlled by lowering the center-of-mass trajectory during stance, forcing the leg to flex and extend as the body moved over the foot contact. For normal step lengths, compliant leg walking was more costly than normal walking gait, but compliant leg walking energetic cost did not increase as rapidly for longer step lengths. This led to an intersection between normal and compliant walking cost curves at 114% relative step length (regression analysis; r 2  = 0.92 for normal walking; r 2  = 0.65 for compliant walking). Compliant leg walking is less energetically demanding at longer step lengths where a spontaneous shift to compliant walking has been observed, suggesting the human motor control system is sensitive to energetic requirements and will employ alternate movement patterns if advantageous strategies are available. The transition could be attributed to the interplay between (i) leg work controlling body travel during single stance and (ii) leg work to control energy loss in the step-to-step transition. Compliant leg walking requires more stance leg work at normal step lengths, but involves less energy loss at the step-to-step transition for very long steps. Copyright © 2018 Elsevier B.V. All rights reserved.

  7. ParticipACTION: Overview and introduction of baseline research on the "new" ParticipACTION

    Directory of Open Access Journals (Sweden)

    Craig Cora L

    2009-12-01

    Full Text Available Abstract Background This paper provides a brief overview of the Canadian physical activity communications and social marketing organization "ParticipACTION"; introduces the "new" ParticipACTION; describes the research process leading to the collection of baseline data on the new ParticipACTION; and outlines the accompanying series of papers in the supplement presenting the detailed baseline data. Methods Information on ParticipACTION was gathered from close personal involvement with the organization, from interviews and meetings with key leaders of the organization, from published literature and from ParticipACTION archives. In 2001, after nearly 30 years of operation, ParticipACTION ceased operations because of inadequate funding. In February 2007 the organization was officially resurrected and the launch of the first mass media campaign of the "new" ParticipACTION occurred in October 2007. The six-year absence of ParticipACTION, or any equivalent substitute, provided a unique opportunity to examine the impact of a national physical activity social marketing organization on important individual and organizational level indicators of success. A rapid response research team was established in January 2007 to exploit this natural intervention research opportunity. Results The research team was successful in obtaining funding through the new Canadian Institutes of Health Research Intervention Research (Healthy Living and Chronic Disease Prevention Funding Program. Data were collected on individuals and organizations prior to the complete implementation of the first mass media campaign of the new ParticipACTION. Conclusion Rapid response research and funding mechanisms facilitated the collection of baseline information on the new ParticipACTION. These data will allow for comprehensive assessments of future initiatives of ParticipACTION.

  8. A role for INDEPTH Asian sites in translating research to action for non-communicable disease prevention and control: a case study from Ballabgarh, India.

    Science.gov (United States)

    Krishnan, Anand; Nongkynrih, Baridalyne; Kapoor, Suresh Kumar; Pandav, Chandrakant

    2009-09-28

    The International Network of field sites with continuous Demographic Evaluation of Populations and Their Health (INDEPTH) has 34 Health and Demographic Surveillance System (HDSS) in 17 different low and middle-income countries. Of these, 23 sites are in Africa, 10 sites are in Asia, and one in Oceania. The INDEPTH HDSS sites in Asia identified chronic non-communicable diseases (NCDs) as a neglected area of attention. As a first step, they conducted NCD risk factor surveys within nine sites in five countries. These sites are now looking to broaden the agenda of research on NCDs using the baseline data to inform policy and practice. A conceptual framework for translating research into action for NCDs at INDEPTH sites was developed. This had five steps - assess the problem, understand the nature of the problem, evaluate different interventions in research mode, implement evidence-based interventions in programme mode, and finally, share knowledge and provide leadership to communities and countries. Ballabgarh HDSS site in India has successfully adopted these steps and is used as a case study to demonstrate how this progress was achieved and what factors were responsible for a successful outcome. Most of the HDSS sites are in the second step of the process of translating research to action (understand the problem). The conduct of NCD risk factor surveys has enabled an assessment of the burden of NCD risk together with determinants in order to understand the burden at the population level. The experience from Ballabgarh HDSS exemplifies that the following steps - pilot testing the interventions, implementing activities in programme mode, and finally, share knowledge and provide leadership - are also possible in rural settings in low-income countries. The critical success factors identified were involvement of a premier medical institution, pre-existing links to policy makers and programme managers, strong commitment of the HDSS team and adequate human resource capacity

  9. Action Research for Democracy

    DEFF Research Database (Denmark)

    , to innovation policies combining Action Research with gender science. In the second part of the book epistemological and ontological dimensions of Action Research are discussed addressing questions of validity criteria related to Action Research, the transformation of knowledge institutions and the specific......Contemporary society encounters profound economical, socio-ecological and political crises challenging the democratic foundation of our societies. This book addresses the potentials and challenges for Action Research supporting democratic alternatives. It offers a broad spectrum of examples from...... Scandinavian Action Research showing different openings towards democratic development. The book’s first part contributes with a wide range of examples such as Action Research in relation to the Triple Helix/Mode II contexts, to design as a democratic process, to renewal of welfare work and public institutions...

  10. Grasp it loudly! Supporting actions with semantically congruent spoken action words.

    Directory of Open Access Journals (Sweden)

    Raphaël Fargier

    Full Text Available Evidence for cross-talk between motor and language brain structures has accumulated over the past several years. However, while a significant amount of research has focused on the interaction between language perception and action, little attention has been paid to the potential impact of language production on overt motor behaviour. The aim of the present study was to test whether verbalizing during a grasp-to-displace action would affect motor behaviour and, if so, whether this effect would depend on the semantic content of the pronounced word (Experiment I. Furthermore, we sought to test the stability of such effects in a different group of participants and investigate at which stage of the motor act language intervenes (Experiment II. For this, participants were asked to reach, grasp and displace an object while overtly pronouncing verbal descriptions of the action ("grasp" and "put down" or unrelated words (e.g. "butterfly" and "pigeon". Fine-grained analyses of several kinematic parameters such as velocity peaks revealed that when participants produced action-related words their movements became faster compared to conditions in which they did not verbalize or in which they produced words that were not related to the action. These effects likely result from the functional interaction between semantic retrieval of the words and the planning and programming of the action. Therefore, links between (action language and motor structures are significant to the point that language can refine overt motor behaviour.

  11. Increasing Running Step Rate Reduces Patellofemoral Joint Forces

    Science.gov (United States)

    Lenhart, Rachel L.; Thelen, Darryl G.; Wille, Christa M.; Chumanov, Elizabeth S.; Heiderscheit, Bryan C.

    2013-01-01

    Purpose Increasing step rate has been shown to elicit changes in joint kinematics and kinetics during running, and has been suggested as a possible rehabilitation strategy for runners with patellofemoral pain. The purpose of this study was to determine how altering step rate affects internal muscle forces and patellofemoral joint loads, and then to determine what kinematic and kinetic factors best predict changes in joint loading. Methods We recorded whole body kinematics of 30 healthy adults running on an instrumented treadmill at three step rate conditions (90%, 100%, and 110% of preferred step rate). We then used a 3D lower extremity musculoskeletal model to estimate muscle, patellar tendon, and patellofemoral joint forces throughout the running gait cycles. Additionally, linear regression analysis allowed us to ascertain the relative influence of limb posture and external loads on patellofemoral joint force. Results Increasing step rate to 110% of preferred reduced peak patellofemoral joint force by 14%. Peak muscle forces were also altered as a result of the increased step rate with hip, knee and ankle extensor forces, and hip abductor forces all reduced in mid-stance. Compared to the 90% step rate condition, there was a concomitant increase in peak rectus femoris and hamstring loads during early and late swing, respectively, at higher step rates. Peak stance phase knee flexion decreased with increasing step rate, and was found to be the most important predictor of the reduction in patellofemoral joint loading. Conclusion Increasing step rate is an effective strategy to reduce patellofemoral joint forces and could be effective in modulating biomechanical factors that can contribute to patellofemoral pain. PMID:23917470

  12. Bio-inspired step-climbing in a hexapod robot

    International Nuclear Information System (INIS)

    Chou, Ya-Cheng; Yu, Wei-Shun; Huang, Ke-Jung; Lin, Pei-Chun

    2012-01-01

    Inspired by the observation that the cockroach changes from a tripod gait to a different gait for climbing high steps, we report on the design and implementation of a novel, fully autonomous step-climbing maneuver, which enables a RHex-style hexapod robot to reliably climb a step up to 230% higher than the length of its leg. Similar to the climbing strategy most used by cockroaches, the proposed maneuver is composed of two stages. The first stage is the ‘rearing stage,’ inclining the body so the front side of the body is raised and it is easier for the front legs to catch the top of the step, followed by the ‘rising stage,’ maneuvering the body's center of mass to the top of the step. Two infrared range sensors are installed on the front of the robot to detect the presence of the step and its orientation relative to the robot's heading, so that the robot can perform automatic gait transition, from walking to step-climbing, as well as correct its initial tilt approaching posture. An inclinometer is utilized to measure body inclination and to compute step height, thus enabling the robot to adjust its gait automatically, in real time, and to climb steps of different heights and depths successfully. The algorithm is applicable for the robot to climb various rectangular obstacles, including a narrow bar, a bar and a step (i.e. a bar of infinite width). The performance of the algorithm is evaluated experimentally, and the comparison of climbing strategies and climbing behaviors in biological and robotic systems is discussed. (paper)

  13. A theory of the stepped leader in lightning

    International Nuclear Information System (INIS)

    Lowke, J.J.

    1999-01-01

    There is no generally accepted explanation of the stepped leader behaviour in terms of basic physical processes. Existing theories generally involve significant gas heating within the stepped leader. In the present paper, the stepped nature of the leader is proposed to arise due to a combination of two physical phenomena. Electron transport is dominant over ion transport, during the luminous step stage, because electron mobilities are about 100 times larger than ion mobilities, and the streamer front velocity is determined by electron ionization effects. During the dark time between steps, there are only ions and charge transport is very much slower. The second effect leading to stepped behaviour arises because the electric field required for electric breakdown in air prior to a discharge is ∼30kV/cm, and is very much higher than the electric field of 5kV/cm that is required to sustain a glow discharge in air. During the luminous step stage, electrons tend to produce space charges to make a uniform field in the streamer of ∼5kV/cm. During the dark time between steps, there are no electrons but only ions. Time is required for ion drift to produce a space charge sheath of negative ions at the head of the streamer to produce a field of ∼30kV/cm sufficient for electron ionization to produce a new luminous step

  14. Linear and nonlinear Biot waves in a noncohesive granular medium slab: transfer function, self-action, second harmonic generation.

    Science.gov (United States)

    Legland, J-B; Tournat, V; Dazel, O; Novak, A; Gusev, V

    2012-06-01

    Experimental results are reported on second harmonic generation and self-action in a noncohesive granular medium supporting wave energy propagation both in the solid frame and in the saturating fluid. The acoustic transfer function of the probed granular slab can be separated into two main frequency regions: a low frequency region where the wave propagation is controlled by the solid skeleton elastic properties, and a higher frequency region where the behavior is dominantly due to the air saturating the beads. Experimental results agree well with a recently developed nonlinear Biot wave model applied to granular media. The linear transfer function, second harmonic generation, and self-action effect are studied as a function of bead diameter, compaction step, excitation amplitude, and frequency. This parametric study allows one to isolate different propagation regimes involving a range of described and interpreted linear and nonlinear processes that are encountered in granular media experiments. In particular, a theoretical interpretation is proposed for the observed strong self-action effect.

  15. New families of superintegrable systems from k-step rational extensions, polynomial algebras and degeneracies

    International Nuclear Information System (INIS)

    Marquette, Ian

    2015-01-01

    Four new families of two-dimensional quantum superintegrable systems are constructed from k-step extension of the harmonic oscillator and the radial oscillator. Their wavefunctions are related with Hermite and Laguerre exceptional orthogonal polynomials (EOP) of type III. We show that ladder operators obtained from alternative construction based on combinations of supercharges in the Krein-Adler and Darboux Crum (or state deleting and creating) approaches can be used to generate a set of integrals of motion and a corresponding polynomial algebra that provides an algebraic derivation of the full spectrum and total number of degeneracies. Such derivation is based on finite dimensional unitary representations (unirreps) and doesn't work for integrals build from standard ladder operators in supersymmetric quantum mechanics (SUSYQM) as they contain singlets isolated from excited states. In this paper, we also rely on a novel approach to obtain the finite dimensional unirreps based on the action of the integrals of motion on the wavefunctions given in terms of these EOP. We compare the results with those obtained from the Daskaloyannis approach and the realizations in terms of deformed oscillator algebras for one of the new families in the case of 1-step extension. This communication is a review of recent works. (paper)

  16. Willed action, free will, and the stochastic neurodynamics of decision-making

    Directory of Open Access Journals (Sweden)

    Edmund eRolls

    2012-09-01

    Full Text Available It is shown that the randomness of the firing times of neurons in decision-making attractor neuronal networks that is present before the decision cues are applied can cause statistical fluctuations that influence the decision that will be taken. In this rigorous sense, it is possible to partially predict decisions before they are made. This raises issues about free will and determinism. There are many decision-making networks in the brain. Some decision systems operate to choose between gene-specified rewards such as taste, touch, and beauty (in for example the peacock’s tail. Other processes capable of planning ahead with multiple steps held in working memory may require correction by higher order thoughts that may involve explicit, conscious, processing. The explicit system can allow the gene-specified rewards not to be selected or deferred. The decisions between the selfish gene-specified rewards, and the explicitly calculated rewards that are in the interests of the individual, the phenotype, may themselves be influenced by noise in the brain. When the explicit planning system does take the decision, it can report on its decision-making, and can provide a causal account rather than a confabulation about the decision process. We might use the terms ‘willed action’ and ‘free will’ to refer to the operation of the planning system that can think ahead over several steps held in working memory with which it can take explicit decisions. Reduced connectivity in some of the default mode cortical regions including the precuneus that are active during self-initiated action appears to be related to the reduction in the sense of self and agency, of causing willed actions, that can be present in schizophrenia.

  17. Robotic retroperitoneal partial nephrectomy: a step-by-step guide.

    Science.gov (United States)

    Ghani, Khurshid R; Porter, James; Menon, Mani; Rogers, Craig

    2014-08-01

    To describe a step-by-step guide for successful implementation of the retroperitoneal approach to robotic partial nephrectomy (RPN) PATIENTS AND METHODS: The patient is placed in the flank position and the table fully flexed to increase the space between the 12th rib and iliac crest. Access to the retroperitoneal space is obtained using a balloon-dilating device. Ports include a 12-mm camera port, two 8-mm robotic ports and a 12-mm assistant port placed in the anterior axillary line cephalad to the anterior superior iliac spine, and 7-8 cm caudal to the ipsilateral robotic port. Positioning and port placement strategies for successful technique include: (i) Docking robot directly over the patient's head parallel to the spine; (ii) incision for camera port ≈1.9 cm (1 fingerbreadth) above the iliac crest, lateral to the triangle of Petit; (iii) Seldinger technique insertion of kidney-shaped balloon dilator into retroperitoneal space; (iv) Maximising distance between all ports; (v) Ensuring camera arm is placed in the outer part of the 'sweet spot'. The retroperitoneal approach to RPN permits direct access to the renal hilum, no need for bowel mobilisation and excellent visualisation of posteriorly located tumours. © 2014 The Authors. BJU International © 2014 BJU International.

  18. Step-wise refolding of recombinant proteins.

    Science.gov (United States)

    Tsumoto, Kouhei; Arakawa, Tsutomu; Chen, Linda

    2010-04-01

    Protein refolding is still on trial-and-error basis. Here we describe step-wise dialysis refolding, in which denaturant concentration is altered in step-wise fashion. This technology controls the folding pathway by adjusting the concentrations of the denaturant and other solvent additives to induce sequential folding or disulfide formation.

  19. U.S. energy policy and next regulatory steps

    International Nuclear Information System (INIS)

    Pearce, D.

    2006-01-01

    This presentation examined energy policies taken in the past to develop to oil and gas activities in Alaska and examined regulatory steps that may be taken in the future. North Slope Alaska gas resources were also reviewed. The Alaska Natural Gas Transportation Act was passed in 1976, but the pipeline was not developed due to its high cost. The Alaska Natural Gas Pipeline Act was signed into law in 2004 along with a loan guarantee program and an alternate construction study. Tax bill provisions included accelerated depreciation for the pipeline as well as an enhanced oil recovery tax credit for a gas processing plant. A federal coordinator was selected to expedite reviews and actions, as well as to monitor responsibility in areas where the pipeline crosses Federal or private lands. Details of federal permitting agencies were also included. A summary of federal agency permits and approvals was provided along with details of a federal interdepartmental memorandum of understanding (MOU) and the responsibilities of the United States Department of Energy. The presentation also included outlines of technical risk management programs, support infrastructure needs, and an infrastructure upgrade study. Highway route options were discussed, as well as sites for facilities. tabs., figs

  20. Corrective Action Decision Document for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    Boehlecke, Robert

    2004-01-01

    The six bunkers included in CAU 204 were primarily used to monitor atmospheric testing or store munitions. The 'Corrective Action Investigation Plan (CAIP) for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada' (NNSA/NV, 2002a) provides information relating to the history, planning, and scope of the investigation; therefore, it will not be repeated in this CADD. This CADD identifies potential corrective action alternatives and provides a rationale for the selection of a recommended corrective action alternative for each CAS within CAU 204. The evaluation of corrective action alternatives is based on process knowledge and the results of investigative activities conducted in accordance with the CAIP (NNSA/NV, 2002a) that was approved prior to the start of the Corrective Action Investigation (CAI). Record of Technical Change (ROTC) No. 1 to the CAIP (approval pending) documents changes to the preliminary action levels (PALs) agreed to by the Nevada Division of Environmental Protection (NDEP) and DOE, National Nuclear Security Administration Nevada Site Office (NNSA/NSO). This ROTC specifically discusses the radiological PALs and their application to the findings of the CAU 204 corrective action investigation. The scope of this CADD consists of the following: (1) Develop corrective action objectives; (2) Identify corrective action alternative screening criteria; (3) Develop corrective action alternatives; (4) Perform detailed and comparative evaluations of corrective action alternatives in relation to corrective action objectives and screening criteria; and (5) Recommend and justify a preferred corrective action alternative for each CAS within CAU 204

  1. Brain-to-brain hyperclassification reveals action-specific motor mapping of observed actions in humans.

    Science.gov (United States)

    Smirnov, Dmitry; Lachat, Fanny; Peltola, Tomi; Lahnakoski, Juha M; Koistinen, Olli-Pekka; Glerean, Enrico; Vehtari, Aki; Hari, Riitta; Sams, Mikko; Nummenmaa, Lauri

    2017-01-01

    Seeing an action may activate the corresponding action motor code in the observer. It remains unresolved whether seeing and performing an action activates similar action-specific motor codes in the observer and the actor. We used novel hyperclassification approach to reveal shared brain activation signatures of action execution and observation in interacting human subjects. In the first experiment, two "actors" performed four types of hand actions while their haemodynamic brain activations were measured with 3-T functional magnetic resonance imaging (fMRI). The actions were videotaped and shown to 15 "observers" during a second fMRI experiment. Eleven observers saw the videos of one actor, and the remaining four observers saw the videos of the other actor. In a control fMRI experiment, one of the actors performed actions with closed eyes, and five new observers viewed these actions. Bayesian canonical correlation analysis was applied to functionally realign observers' and actors' fMRI data. Hyperclassification of the seen actions was performed with Bayesian logistic regression trained on actors' data and tested with observers' data. Without the functional realignment, between-subjects accuracy was at chance level. With the realignment, the accuracy increased on average by 15 percentage points, exceeding both the chance level and the accuracy without functional realignment. The highest accuracies were observed in occipital, parietal and premotor cortices. Hyperclassification exceeded chance level also when the actor did not see her own actions. We conclude that the functional brain activation signatures underlying action execution and observation are partly shared, yet these activation signatures may be anatomically misaligned across individuals.

  2. Two-step versus one-step FT4 assays in heparin treated patients and non-thyroidal illness

    International Nuclear Information System (INIS)

    Reiners, C.; Bieler, G.; Ertl, G.; Gloss, H.; Boerner, W.

    1985-01-01

    The primary intention of this study is to inform the clinician about the direction and the order of magnitude of possible disturbances of different FT 4 parameters under the condition mentioned last, which is not uncommon in daily routine. No single FT 4 -RIA proved be valid in severe NTI. There is the risk to misinterprete hyperthyroidism as euthyroidism with 1step assays and the possibility to classify euthyroid patients falsely as hyperthyroid with 2step assays. In relation to this problem, the sometimes lowered FT 4 values by 1step methods are clinically not so important. It has to be established, wether TSH assays of high sensitivity are able to overcome some of the difficulties with determinations of peripheral thyroid hormones in NTI. (orig./MG)

  3. Corrective Action Investigation Plan for Corrective Action Unit 127: Areas 25 and 26 Storage Tanks, Nevada Test Site, Nevada (Rev. No.: 0, August 2002)

    Energy Technology Data Exchange (ETDEWEB)

    NNSA/NV

    2002-08-27

    contaminated materials. Future land-use scenarios limit subsequent uses of the CASs to various nonresidential (i.e., industrial) activities. Field activities will consist of radiological walkover and screening surveys, and field-screening and collecting of both tank content and soil samples, and further sample testing as appropriate. A two-step data quality objective strategy will be followed: (1) Phase I will be to collect environmental samples for laboratory analysis to confirm the presence or absence of contaminants at concentrations exceeding preliminary action levels; and (2) Phase II will be to collect additional environmental samples for laboratory analysis to determine the extent of contamination identified in Phase I. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document.

  4. The minimalist grammar of action

    Science.gov (United States)

    Pastra, Katerina; Aloimonos, Yiannis

    2012-01-01

    Language and action have been found to share a common neural basis and in particular a common ‘syntax’, an analogous hierarchical and compositional organization. While language structure analysis has led to the formulation of different grammatical formalisms and associated discriminative or generative computational models, the structure of action is still elusive and so are the related computational models. However, structuring action has important implications on action learning and generalization, in both human cognition research and computation. In this study, we present a biologically inspired generative grammar of action, which employs the structure-building operations and principles of Chomsky's Minimalist Programme as a reference model. In this grammar, action terminals combine hierarchically into temporal sequences of actions of increasing complexity; the actions are bound with the involved tools and affected objects and are governed by certain goals. We show, how the tool role and the affected-object role of an entity within an action drives the derivation of the action syntax in this grammar and controls recursion, merge and move, the latter being mechanisms that manifest themselves not only in human language, but in human action too. PMID:22106430

  5. Seven steps to curb global warming

    International Nuclear Information System (INIS)

    Mathews, John

    2007-01-01

    Based on best current estimates that the world needs to reduce global carbon dioxide emissions by 70% by 2050, and that there is at best a 10-year window of opportunity available to initiate the enormous changes needed, this paper proposes a set of seven self-contained steps that can be taken at a global level to tackle the problem with some prospect of success. The steps are self-financing and practicable, in that they are based on existing technologies. They involve agreement to create a new international agency charged with formulating and policing a global carbon pricing regime; a complementary step involving global monitoring of greenhouse gas emissions utilizing satellite resources; taking steps to compensate developing countries for preserving rainforest as carbon sinks; the dismantling of newly created trade barriers holding back global trade in biofuels; global promotion of a transition to renewable sources of electricity through facilitation of grid interconnections with independent power producers; a global moratorium on the building of new coal-fired power stations; and recycling of carbon revenues to promote uptake of renewable energy sources in developing countries, particularly Brazil, India and China. Taken as a group, it is argued that these steps are both necessary and sufficient. They call for institutional innovations at a global level that are politically difficult but feasible, given the magnitude of the problems addressed

  6. Enforcement actions: Significant actions resolved individual actions. Semiannual progress report, January 1997--June 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    This compilation summarizes significant enforcement actions that have been resolved during the period (January - June 1997) and includes copies of Orders and Notices of Violation sent by the Nuclear Regulatory Commission to individuals with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC. The Commission believes this information may be useful to licensees in making employment decisions.

  7. Enforcement actions: Significant actions resolved individual actions. Semiannual progress report, January 1997--June 1997

    International Nuclear Information System (INIS)

    1997-09-01

    This compilation summarizes significant enforcement actions that have been resolved during the period (January - June 1997) and includes copies of Orders and Notices of Violation sent by the Nuclear Regulatory Commission to individuals with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC. The Commission believes this information may be useful to licensees in making employment decisions

  8. What good are actions? Accelerating learning using learned action priors

    CSIR Research Space (South Africa)

    Rosman, Benjamin S

    2012-11-01

    Full Text Available The computational complexity of learning in sequential decision problems grows exponentially with the number of actions available to the agent at each state. We present a method for accelerating this process by learning action priors that express...

  9. A Spiral Step-by-Step Educational Method for Cultivating Competent Embedded System Engineers to Meet Industry Demands

    Science.gov (United States)

    Jing,Lei; Cheng, Zixue; Wang, Junbo; Zhou, Yinghui

    2011-01-01

    Embedded system technologies are undergoing dramatic change. Competent embedded system engineers are becoming a scarce resource in the industry. Given this, universities should revise their specialist education to meet industry demands. In this paper, a spirally tight-coupled step-by-step educational method, based on an analysis of industry…

  10. Human exposure assessment for biocides in the EU development of step by step guidance and worked examples

    NARCIS (Netherlands)

    Gerritsen-Ebben, R.M.G.; Hemmen, J.J. van

    2007-01-01

    Directive 98/8/EC(1) concerns EU harmonisation of placing biocidal products on the market. In the present short paper the preliminary results of an ongoing project are presented in which step by step guidance on human exposure assessment with worked examples is developed. For all 23 biocidal product

  11. Steps in Performing a Communication Audit.

    Science.gov (United States)

    Sincoff, Michael Z.; And Others

    This paper develops the step-by-step processes necessary to conduct a communication audit in order to determine the communication effectiveness of an organization. The authors stress the responsibilities of both the audit team and the organization's top management as they interact during progressive phases of the audit. Emphasis is placed on…

  12. Follow These Step-by-Step Instructions to Prevent Avoidable Tumbles at School.

    Science.gov (United States)

    Pater, Robert; And Others

    1987-01-01

    Almost a quarter of disabling work injuries among school employees are caused by slips and falls. Outlines prevention steps and safety programs that can help lower the possibilities of accidents from falls in schools. (MD)

  13. Subliminal action priming modulates the perceived intensity of sensory action consequences.

    Science.gov (United States)

    Stenner, Max-Philipp; Bauer, Markus; Sidarus, Nura; Heinze, Hans-Jochen; Haggard, Patrick; Dolan, Raymond J

    2014-02-01

    The sense of control over the consequences of one's actions depends on predictions about these consequences. According to an influential computational model, consistency between predicted and observed action consequences attenuates perceived stimulus intensity, which might provide a marker of agentic control. An important assumption of this model is that these predictions are generated within the motor system. However, previous studies of sensory attenuation have typically confounded motor-specific perceptual modulation with perceptual effects of stimulus predictability that are not specific to motor action. As a result, these studies cannot unambiguously attribute sensory attenuation to a motor locus. We present a psychophysical experiment on auditory attenuation that avoids this pitfall. Subliminal masked priming of motor actions with compatible prime-target pairs has previously been shown to modulate both reaction times and the explicit feeling of control over action consequences. Here, we demonstrate reduced perceived loudness of tones caused by compatibly primed actions. Importantly, this modulation results from a manipulation of motor processing and is not confounded by stimulus predictability. We discuss our results with respect to theoretical models of the mechanisms underlying sensory attenuation and subliminal motor priming. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

  14. Mirroring "meaningful" actions: sensorimotor learning modulates imitation of goal-directed actions.

    Science.gov (United States)

    Catmur, Caroline; Heyes, Cecilia

    2017-06-19

    Imitation is important in the development of social and technological skills throughout the lifespan. Experiments investigating the acquisition and modulation of imitation (and of its proposed neural substrate, the mirror neuron system) have produced evidence that the capacity for imitation depends on associative learning in which connections are formed between sensory and motor representations of actions. However, evidence that the development of imitation depends on associative learning has been found only for non-goal-directed actions. One reason for the lack of research on goal-directed actions is that imitation of such actions is commonly confounded with the tendency to respond in a spatially compatible manner. However, since the most prominent account of mirror neuron function, and hence of imitation, suggests that these cells encode goal-directed actions, it is important to establish whether sensorimotor learning can also modulate imitation of goal-directed actions. Experiment 1 demonstrated that imitation of goal-directed grasping can be measured while controlling for spatial compatibility, and Experiment 2 showed that this imitation effect can be modulated by sensorimotor training. Together these data support the hypothesis that the capacity for behavioural imitation, and the properties of the mirror neuron system, are constructed in the course of development through associative learning.

  15. Draft program plan for TNS: the next step after the tokamak fusion test reactor. Part I. Summary

    International Nuclear Information System (INIS)

    Roberts, M.

    1977-10-01

    A draft program plan for TNS has been prepared which consists of two basic parts--an R and D Needs Assessment and a Project Plan with schedules and necessary implementation steps. In this brief but intensive effort, questions concerning (1) the present basis for the TNS program, (2) the principal gaps in the supporting program, and (3) the necessary actions to be taken to implement the TNS program were examined. The study supported the thesis that the physics and technology bases do exist from which to start the TNS design as a central fusion program goal. Specific recommendations are made to emphasize those physics, technology, and engineering areas in which there are program gaps. In the project engineering study, a basic schedule with close support from the R and D program is developed from which recommendations on administrative actions and areas for further elucidation are made. This document presents in summary form the findings of the study, the development of the principal theses, and the recommendation to ERDA-DMFE

  16. A Pragmatic Randomized Controlled Trial of 6-Step vs 3-Step Hand Hygiene Technique in Acute Hospital Care in the United Kingdom.

    Science.gov (United States)

    Reilly, Jacqui S; Price, Lesley; Lang, Sue; Robertson, Chris; Cheater, Francine; Skinner, Kirsty; Chow, Angela

    2016-06-01

    OBJECTIVE To evaluate the microbiologic effectiveness of the World Health Organization's 6-step and the Centers for Disease Control and Prevention's 3-step hand hygiene techniques using alcohol-based handrub. DESIGN A parallel group randomized controlled trial. SETTING An acute care inner-city teaching hospital (Glasgow). PARTICIPANTS Doctors (n=42) and nurses (n=78) undertaking direct patient care. INTERVENTION Random 1:1 allocation of the 6-step (n=60) or the 3-step (n=60) technique. RESULTS The 6-step technique was microbiologically more effective at reducing the median log10 bacterial count. The 6-step technique reduced the count from 3.28 CFU/mL (95% CI, 3.11-3.38 CFU/mL) to 2.58 CFU/mL (2.08-2.93 CFU/mL), whereas the 3-step reduced it from 3.08 CFU/mL (2.977-3.27 CFU/mL) to 2.88 CFU/mL (-2.58 to 3.15 CFU/mL) (P=.02). However, the 6-step technique did not increase the total hand coverage area (98.8% vs 99.0%, P=.15) and required 15% (95% CI, 6%-24%) more time (42.50 seconds vs 35.0 seconds, P=.002). Total hand coverage was not related to the reduction in bacterial count. CONCLUSIONS Two techniques for hand hygiene using alcohol-based handrub are promoted in international guidance, the 6-step by the World Health Organization and 3-step by the Centers for Disease Control and Prevention. The study provides the first evidence in a randomized controlled trial that the 6-step technique is superior, thus these international guidance documents should consider this evidence, as should healthcare organizations using the 3-step technique in practice. Infect Control Hosp Epidemiol 2016;37:661-666.

  17. Stepping strategies for regulating gait adaptability and stability.

    Science.gov (United States)

    Hak, Laura; Houdijk, Han; Steenbrink, Frans; Mert, Agali; van der Wurff, Peter; Beek, Peter J; van Dieën, Jaap H

    2013-03-15

    Besides a stable gait pattern, gait in daily life requires the capability to adapt this pattern in response to environmental conditions. The purpose of this study was to elucidate the anticipatory strategies used by able-bodied people to attain an adaptive gait pattern, and how these strategies interact with strategies used to maintain gait stability. Ten healthy subjects walked in a Computer Assisted Rehabilitation ENvironment (CAREN). To provoke an adaptive gait pattern, subjects had to hit virtual targets, with markers guided by their knees, while walking on a self-paced treadmill. The effects of walking with and without this task on walking speed, step length, step frequency, step width and the margins of stability (MoS) were assessed. Furthermore, these trials were performed with and without additional continuous ML platform translations. When an adaptive gait pattern was required, subjects decreased step length (padaptations resulted in the preservation of equal MoS between trials, despite the disturbing influence of the gait adaptability task. When the gait adaptability task was combined with the balance perturbation subjects further decreased step length, as evidenced by a significant interaction between both manipulations (p=0.012). In conclusion, able-bodied people reduce step length and increase step width during walking conditions requiring a high level of both stability and adaptability. Although an increase in step frequency has previously been found to enhance stability, a faster movement, which would coincide with a higher step frequency, hampers accuracy and may consequently limit gait adaptability. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Linear micromechanical stepping drive for pinhole array positioning

    International Nuclear Information System (INIS)

    Endrödy, Csaba; Mehner, Hannes; Hoffmann, Martin; Grewe, Adrian

    2015-01-01

    A compact linear micromechanical stepping drive for positioning a 7 × 5.5 mm 2 optical pinhole array is presented. The system features a step size of 13.2 µm and a full displacement range of 200 µm. The electrostatic inch-worm stepping mechanism shows a compact design capable of positioning a payload 50% of its own weight. The stepping drive movement, step sizes and position accuracy are characterized. The actuated pinhole array is integrated in a confocal chromatic hyperspectral imaging system, where coverage of the object plane, and therefore the useful picture data, can be multiplied by 14 in contrast to a non-actuated array. (paper)

  19. Numerical characterisation of one-step and three-step solar air heating collectors used for cocoa bean solar drying.

    Science.gov (United States)

    Orbegoso, Elder Mendoza; Saavedra, Rafael; Marcelo, Daniel; La Madrid, Raúl

    2017-12-01

    In the northern coastal and jungle areas of Peru, cocoa beans are dried using artisan methods, such as direct exposure to sunlight. This traditional process is time intensive, leading to a reduction in productivity and, therefore, delays in delivery times. The present study was intended to numerically characterise the thermal behaviour of three configurations of solar air heating collectors in order to determine which demonstrated the best thermal performance under several controlled operating conditions. For this purpose, a computational fluid dynamics model was developed to describe the simultaneous convective and radiative heat transfer phenomena under several operation conditions. The constructed computational fluid dynamics model was firstly validated through comparison with the data measurements of a one-step solar air heating collector. We then simulated two further three-step solar air heating collectors in order to identify which demonstrated the best thermal performance in terms of outlet air temperature and thermal efficiency. The numerical results show that under the same solar irradiation area of exposition and operating conditions, the three-step solar air heating collector with the collector plate mounted between the second and third channels was 67% more thermally efficient compared to the one-step solar air heating collector. This is because the air exposition with the surface of the collector plate for the three-step solar air heating collector former device was twice than the one-step solar air heating collector. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. On the Equivalence between Small-Step and Big-Step Abstract Machines: A Simple Application of Lightweight Fusion

    DEFF Research Database (Denmark)

    Danvy, Olivier; Millikin, Kevin

    2007-01-01

    -step specification. We illustrate this observation here with a recognizer for Dyck words, the CEK machine, and Krivine's machine with call/cc. The need for such a simple proof is motivated by our current work on small-step abstract machines as obtained by refocusing a function implementing a reduction semantics (a...

  1. Design and fabrication of a chitosan hydrogel with gradient structures via a step-by-step cross-linking process.

    Science.gov (United States)

    Xu, Yongxiang; Yuan, Shenpo; Han, Jianmin; Lin, Hong; Zhang, Xuehui

    2017-11-15

    The development of scaffolds to mimic the gradient structure of natural tissue is an important consideration for effective tissue engineering. In the present study, a physical cross-linking chitosan hydrogel with gradient structures was fabricated via a step-by-step cross-linking process using sodium tripolyphosphate and sodium hydroxide as sequential cross-linkers. Chitosan hydrogels with different structures (single, double, and triple layers) were prepared by modifying the gelling process. The properties of the hydrogels were further adjusted by varying the gelling conditions, such as gelling time, pH, and composition of the crosslinking solution. Slight cytotoxicity was showed in MTT assay for hydrogels with uncross-linking chitosan solution and non-cytotoxicity was showed for other hydrogels. The results suggest that step-by-step cross-linking represents a practicable method to fabricate scaffolds with gradient structures. Copyright © 2017. Published by Elsevier Ltd.

  2. Random Walks with Anti-Correlated Steps

    OpenAIRE

    Wagner, Dirk; Noga, John

    2005-01-01

    We conjecture the expected value of random walks with anti-correlated steps to be exactly 1. We support this conjecture with 2 plausibility arguments and experimental data. The experimental analysis includes the computation of the expected values of random walks for steps up to 22. The result shows the expected value asymptotically converging to 1.

  3. Randomness in multi-step direct reactions

    International Nuclear Information System (INIS)

    Koning, A.J.; Akkermans, J.M.

    1991-01-01

    The authors propose a quantum-statistical framework that provides an integrated perspective on the differences and similarities between the many current models for multi-step direct reactions in the continuum. It is argued that to obtain a statistical theory two physically different approaches are conceivable to postulate randomness, respectively called leading-particle statistics and residual-system statistics. They present a new leading-particle statistics theory for multi-step direct reactions. It is shown that the model of Feshbach et al. can be derived as a simplification of this theory and thus can be founded solely upon leading-particle statistics. The models developed by Tamura et al. and Nishioka et al. are based upon residual-system statistics and hence fall into a physically different class of multi-step direct theories, although the resulting cross-section formulae for the important first step are shown to be the same. The widely used semi-classical models such as the generalized exciton model can be interpreted as further phenomenological simplification of the leading-particle statistics theory

  4. Staying mindful in action

    DEFF Research Database (Denmark)

    Svalgaard, Lotte

    2016-01-01

    Action Learning is a well-proven method to integrate ‘task’ and ‘process’, as learning about team and self (process) takes place while delivering on a task or business challenge of real importance (task). An Action Lab® is an intensive Action Learning programme lasting for 5 days, which aims...... at balancing and integrating individual challenges and business challenges, as well as the ‘Action’ and the ‘Learning’ of Action Learning. However, in spite of the aspiration to balance and integrate ‘task’ and ‘process’, a tendency and a challenge is experienced: When deeply involved in delivering...... this tendency by sharing a study looking into what hinders and promotes mindful awareness on the process, while dealing with a business challenge in an Action Lab®. Drawing on the findings, the account of practice will share some recommendations for the Action Learning facilitator to take up the challenge...

  5. Increasing preferred step rate during running reduces plantar pressures.

    Science.gov (United States)

    Gerrard, James M; Bonanno, Daniel R

    2018-01-01

    Increasing preferred step rate during running is a commonly used strategy in the management of running-related injuries. This study investigated the effect of different step rates on plantar pressures during running. Thirty-two healthy runners ran at a comfortable speed on a treadmill at five step rates (preferred, ±5%, and ±10%). For each step rate, plantar pressure data were collected using the pedar-X in-shoe system. Compared to running with a preferred step rate, a 10% increase in step rate significantly reduced peak pressure (144.5±46.5 vs 129.3±51 kPa; P=.033) and maximum force (382.3±157.6 vs 334.0±159.8 N; P=.021) at the rearfoot, and reduced maximum force (426.4±130.4 vs 400.0±116.6 N; P=.001) at the midfoot. In contrast, a 10% decrease in step rate significantly increased peak pressure (144.5±46.5 vs 161.5±49.3 kPa; P=.011) and maximum force (382.3±157.6 vs 425.4±155.3 N; P=.032) at the rearfoot. Changing step rate by 5% provided no effect on plantar pressures, and no differences in plantar pressures were observed at the medial forefoot, lateral forefoot or hallux between the step rates. This study's findings indicate that increasing preferred step rate by 10% during running will reduce plantar pressures at the rearfoot and midfoot, while decreasing step rate by 10% will increase plantar pressures at the rearfoot. However, changing preferred step rate by 5% will provide no effect on plantar pressures, and forefoot pressures are unaffected by changes in step rate. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Partial Actions and Power Sets

    Directory of Open Access Journals (Sweden)

    Jesús Ávila

    2013-01-01

    Full Text Available We consider a partial action (X,α with enveloping action (T,β. In this work we extend α to a partial action on the ring (P(X,Δ,∩ and find its enveloping action (E,β. Finally, we introduce the concept of partial action of finite type to investigate the relationship between (E,β and (P(T,β.

  7. The Relaxation of Vicinal (001) with ZigZag [110] Steps

    Science.gov (United States)

    Hawkins, Micah; Hamouda, Ajmi Bh; González-Cabrera, Diego Luis; Einstein, Theodore L.

    2012-02-01

    This talk presents a kinetic Monte Carlo study of the relaxation dynamics of [110] steps on a vicinal (001) simple cubic surface. This system is interesting because [110] steps have different elementary excitation energetics and favor step diffusion more than close-packed [100] steps. In this talk we show how this leads to relaxation dynamics showing greater fluctuations on a shorter time scale for [110] steps as well as 2-bond breaking processes being rate determining in contrast to 3-bond breaking processes for [100] steps. The existence of a steady state is shown via the convergence of terrace width distributions at times much longer than the relaxation time. In this time regime excellent fits to the modified generalized Wigner distribution (as well as to the Berry-Robnik model when steps can overlap) were obtained. Also, step-position correlation function data show diffusion-limited increase for small distances along the step as well as greater average step displacement for zigzag steps compared to straight steps for somewhat longer distances along the step. Work supported by NSF-MRSEC Grant DMR 05-20471 as well as a DOE-CMCSN Grant.

  8. The Polytopic-k-Step Fibonacci Sequences in Finite Groups

    Directory of Open Access Journals (Sweden)

    Ömür Deveci

    2011-01-01

    Full Text Available We study the polytopic-k-step Fibonacci sequences, the polytopic-k-step Fibonacci sequences modulo m, and the polytopic-k-step Fibonacci sequences in finite groups. Also, we examine the periods of the polytopic-k-step Fibonacci sequences in semidihedral group SD2m.

  9. Perinatal Depression Algorithm: A Home Visitor Step-by-Step Guide for Advanced Management of Perinatal Depressive Symptoms

    Science.gov (United States)

    Laszewski, Audrey; Wichman, Christina L.; Doering, Jennifer J.; Maletta, Kristyn; Hammel, Jennifer

    2016-01-01

    Early childhood professionals do many things to support young families. This is true now more than ever, as researchers continue to discover the long-term benefits of early, healthy, nurturing relationships. This article provides an overview of the development of an advanced practice perinatal depression algorithm created as a step-by-step guide…

  10. Preparation for Compensatory Forward Stepping in Parkinson’s Disease

    Science.gov (United States)

    King, Laurie A.; St George, Rebecca J.; Carlson-Kuhta, Patricia; Nutt, John G.; Horak, Fay B.

    2010-01-01

    Objective To characterize preparation for compensatory stepping in people with Parkinson’s disease (PD) compared with healthy control subjects, and to determine whether levodopa medication improves preparation or the execution phases of the step. Design Observational study. Setting Outpatient neuroscience laboratory. Participants Nineteen participants with idiopathic PD tested both in the on and off levodopa states and 17 healthy subjects. Intervention Moveable platform with posterior translations of 24cm at 56cm/s. Main Outcome Measures Compensatory steps forward, in response to a backward surface translation (24cm amplitude at 56cm/s), were categorized according to the presence of an anticipatory postural adjustment (APA) before stepping: no APA, single APA, or multiple APAs. The following step parameters were calculated: step latency, step length, center of mass (CoM) average velocity, and CoM displacement at the step initiation. Results Lateral APAs were evident in 57% and 42% of trials for people with PD in the off and on medication states, respectively, compared with only 10% of trials for control subjects. Compared with subjects with PD who did not have APAs, those subjects with PD who did make an APA prior to stepping had significantly later (mean ± SEM, 356 ± 16ms vs 305 ± 8ms) and shorter (mean ± SEM, 251 ± 27mm vs 300 ± 16mm) steps, their CoM was significantly farther forward (185 ± 7mm vs 171 ± 5mm) at foot-off, and they took significantly more steps to regain equilibrium. Levodopa did not affect the preparation or execution phase of compensatory stepping. Poor axial scores and reports of freezing in the United Parkinson’s Disease Rating Scale were associated with use of 1 or more APAs before compensatory stepping. Conclusions Lateral postural preparation prior to compensatory stepping in subjects with PD was associated with inefficient balance recovery from external perturbations. PMID:20801249

  11. Developing a National Tiger Action Plan for the Union of Myanmar

    Science.gov (United States)

    Lynam, Antony J.; Khaing, Saw Tun; Zaw, Khin Maung

    2006-01-01

    A century ago, tigers were considered pests in Myanmar. Hunters claimed thousands, yet populations persisted. In the past century, because of habitat loss and prey depletion, coupled with the recent demand for traditional medicines, tiger populations have been reduced to a few hundred individuals. As a first step toward long-term planning for tigers, and to guide efforts to increase protected area coverage, the Myanmar government in 1998 initiated a project to develop a revised National Tiger Action Plan. Extensive surveys confirmed tigers in only 4 of 17 survey locations. Significant populations are thought to persist in the far North and far South of the country, where large, intact forests offer the potential for tiger recovery. With partnerships and collaborations, tiger populations can be protected in the short term (laws. Over the long term (5-20 years), recovery of Myanmar’s tiger populations will depend on increasing support from local people, zoning tiger areas to reduce habitat loss and disturbance, and maintaining connectivity of existing national and transboundary forests. This article reviews the development of a new National Tiger Action Plan for the Union of Myanmar and discusses a blueprint for conservation measures aimed at saving tigers from extinction.

  12. What's an Asthma Action Plan?

    Science.gov (United States)

    ... Educators Search English Español What's an Asthma Action Plan? KidsHealth / For Parents / What's an Asthma Action Plan? ... acción contra el asma? What's an Asthma Action Plan? An asthma action plan (or management plan) is ...

  13. PIV Study of Aeration Efficient of Stepped Spillway System

    Science.gov (United States)

    Abas, M. A.; Jamil, R.; Rozainy, M. R.; Zainol, M. A.; Adlan, M. N.; Keong, C. W.

    2017-06-01

    This paper investigates the three-dimensional (3D) simulation of Cascade aerator system using Lattice Boltzmann simulation and laboratory experiment was carried out to investigate the flow, aeration and cavitation in the spillway. Different configurations of stepped spillway are designed in this project in order to investigate the relationship between the configurations of stepped spillway and cavitation in the flow. The aeration in the stepped spillway will also be investigated. The experimental result will be compared with the simulated result at the end of this project. The figure of flow pattern at the 3rd step in simulation and experiment for Set 1 and Set 2 are look similar between LBM simulation and the experiment findings. This will provide a better understanding of the cavitation, aeration and flow in different configurations of the stepped spillway. In addition the occurrence of negative pressure region in the stepped spillway, increases the possibility of cavitation to occur. The cavitation will damage the structure of the stepped spillway. Furthermore, it also founds that increasing in barrier thickness of the stepped spillway will improve the aeration efficiency and reduce the cavitation in stepped spillway.

  14. Action of amylolytic and pullulytic enzymes from various anaerobic thermophiles on linear and branched glucose polymers

    Energy Technology Data Exchange (ETDEWEB)

    Koch, R [Goettingen Univ. (Germany, F.R.). Inst. fuer Mikrobiologie; Antranikian, G [Technische Univ. Hamburg-Harburg, Hamburg (Germany, F.R.). Arbeitsbereich Biotechnologie 1

    1990-10-01

    A detailed study has been conducted on the action of starch hydrolyzing enzymes from thermophilic anaerobic bacteria belonging to the genera Clostridium, Thermoanaerobacter and Thermobacteroides. The appearance of multiple bands on polyacrylamide gels with amylolytic as well as pullulytic activities was shown to be a general feature of bacteria investigated. Analysis of the hydrolysis products of each protein band clearly demonstrated the capability of these organisms to hydrolyze {alpha}-1,4-glycosidic bonds in linear oligosaccharides and {alpha}-1,6-glycosidic linkages in pullulan. Furthermore, the enzyme system of thermophilic bacteria investigated was also capable of attacking in the {alpha}-1,6-linkages in branched oligosaccharides. Due to the action of these thermoactive enzymes with multiple specificity an almost complete hydrolysis of raw starch and maltodextrin could be achieved under the same conditions and in one step. (orig.).

  15. One-loop effective action for non-local modified Gauss-Bonnet gravity in de Sitter space

    Energy Technology Data Exchange (ETDEWEB)

    Cognola, Guido; Zerbini, Sergio [Universita di Trento (Italy); Istituto Nazionale di Fisica Nucleare Gruppo Collegato di Trento, Dipartimento di Fisica, Trento (Italy); Elizalde, Emilio [Consejo Superior de Investigaciones Cientificas (ICE/CSIC) and Institut d' Estudis Espacials de Catalunya (IEEC), Facultat Ciencies, Bellaterra (Barcelona) (Spain); Nojiri, Shin' ichi [Nagoya University, Department of Physics, Nagoya (Japan); Odintsov, Sergei D. [Consejo Superior de Investigaciones Cientificas (ICE/CSIC) and Institut d' Estudis Espacials de Catalunya (IEEC), Facultat Ciencies, Bellaterra (Barcelona) (Spain); ICREA, Barcelona (Spain); TSPU, Center of Theor. Phys., Tomsk (Russian Federation)

    2009-12-15

    We discuss the classical and quantum properties of non-local modified Gauss-Bonnet gravity in de Sitter space, using its equivalent representation via string-inspired local scalar-Gauss-Bonnet gravity with a scalar potential. A classical, multiple de Sitter universe solution is found where one of the de Sitter phases corresponds to the primordial inflationary epoch, while the other de Sitter space solution - the one with the smallest Hubble rate - describes the late-time acceleration of our universe. A Chameleon scenario for the theory under investigation is developed, and it is successfully used to show that the theory complies with gravitational tests. An explicit expression for the one-loop effective action for this non-local modified Gauss-Bonnet gravity in the de Sitter space is obtained. It is argued that this effective action might be an important step towards the solution of the cosmological constant problem. (orig.)

  16. Small Town Energy Program (STEP) Final Report revised

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Charles (Chuck) T.

    2014-01-02

    University Park, Maryland (“UP”) is a small town of 2,540 residents, 919 homes, 2 churches, 1 school, 1 town hall, and 1 breakthrough community energy efficiency initiative: the Small Town Energy Program (“STEP”). STEP was developed with a mission to “create a model community energy transformation program that serves as a roadmap for other small towns across the U.S.” STEP first launched in January 2011 in UP and expanded in July 2012 to the neighboring communities of Hyattsville, Riverdale Park, and College Heights Estates, MD. STEP, which concluded in July 2013, was generously supported by a grant from the U.S. Department of Energy (DOE). The STEP model was designed for replication in other resource-constrained small towns similar to University Park - a sector largely neglected to date in federal and state energy efficiency programs. STEP provided a full suite of activities for replication, including: energy audits and retrofits for residential buildings, financial incentives, a community-based social marketing backbone and local community delivery partners. STEP also included the highly innovative use of an “Energy Coach” who worked one-on-one with clients throughout the program. Please see www.smalltownenergy.org for more information. In less than three years, STEP achieved the following results in University Park: • 30% of community households participated voluntarily in STEP; • 25% of homes received a Home Performance with ENERGY STAR assessment; • 16% of households made energy efficiency improvements to their home; • 64% of households proceeded with an upgrade after their assessment; • 9 Full Time Equivalent jobs were created or retained, and 39 contractors worked on STEP over the course of the project. Estimated Energy Savings - Program Totals kWh Electricity 204,407 Therms Natural Gas 24,800 Gallons of Oil 2,581 Total Estimated MMBTU Saved (Source Energy) 5,474 Total Estimated Annual Energy Cost Savings $61,343 STEP clients who

  17. StepByStep : design of an interactive pictorial activity game for teaching generalization skills to children with autism

    NARCIS (Netherlands)

    Gruarin, A.; Westenberg, M.A.; Barakova, E.I.; Anacleto, J.C.; Clua, E.W.G.; Correa da Silva, F.S.; Fels, S.; Yang, H.S.

    2013-01-01

    Translating acquired behavioral skills from training environments to daily-life situations is difficult for children with autism. This study introduces the StepByStep platform, in which pictorial activity schedules are implemented. Design decisions that increase the sameness in the environment and

  18. Steps and dislocations in cubic lyotropic crystals

    International Nuclear Information System (INIS)

    Leroy, S; Pieranski, P

    2006-01-01

    It has been shown recently that lyotropic systems are convenient for studies of faceting, growth or anisotropic surface melting of crystals. All these phenomena imply the active contribution of surface steps and bulk dislocations. We show here that steps can be observed in situ and in real time by means of a new method combining hygroscopy with phase contrast. First results raise interesting issues about the consequences of bicontinuous topology on the structure and dynamical behaviour of steps and dislocations

  19. Population of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisation.

    Directory of Open Access Journals (Sweden)

    Philip Gemmell

    Full Text Available Variability is observed at all levels of cardiac electrophysiology. Yet, the underlying causes and importance of this variability are generally unknown, and difficult to investigate with current experimental techniques. The aim of the present study was to generate populations of computational ventricular action potential models that reproduce experimentally observed intercellular variability of repolarisation (represented by action potential duration and to identify its potential causes. A systematic exploration of the effects of simultaneously varying the magnitude of six transmembrane current conductances (transient outward, rapid and slow delayed rectifier K(+, inward rectifying K(+, L-type Ca(2+, and Na(+/K(+ pump currents in two rabbit-specific ventricular action potential models (Shannon et al. and Mahajan et al. at multiple cycle lengths (400, 600, 1,000 ms was performed. This was accomplished with distributed computing software specialised for multi-dimensional parameter sweeps and grid execution. An initial population of 15,625 parameter sets was generated for both models at each cycle length. Action potential durations of these populations were compared to experimentally derived ranges for rabbit ventricular myocytes. 1,352 parameter sets for the Shannon model and 779 parameter sets for the Mahajan model yielded action potential duration within the experimental range, demonstrating that a wide array of ionic conductance values can be used to simulate a physiological rabbit ventricular action potential. Furthermore, by using clutter-based dimension reordering, a technique that allows visualisation of multi-dimensional spaces in two dimensions, the interaction of current conductances and their relative importance to the ventricular action potential at different cycle lengths were revealed. Overall, this work represents an important step towards a better understanding of the role that variability in current conductances may play in

  20. Population of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisation.

    Science.gov (United States)

    Gemmell, Philip; Burrage, Kevin; Rodriguez, Blanca; Quinn, T Alexander

    2014-01-01

    Variability is observed at all levels of cardiac electrophysiology. Yet, the underlying causes and importance of this variability are generally unknown, and difficult to investigate with current experimental techniques. The aim of the present study was to generate populations of computational ventricular action potential models that reproduce experimentally observed intercellular variability of repolarisation (represented by action potential duration) and to identify its potential causes. A systematic exploration of the effects of simultaneously varying the magnitude of six transmembrane current conductances (transient outward, rapid and slow delayed rectifier K(+), inward rectifying K(+), L-type Ca(2+), and Na(+)/K(+) pump currents) in two rabbit-specific ventricular action potential models (Shannon et al. and Mahajan et al.) at multiple cycle lengths (400, 600, 1,000 ms) was performed. This was accomplished with distributed computing software specialised for multi-dimensional parameter sweeps and grid execution. An initial population of 15,625 parameter sets was generated for both models at each cycle length. Action potential durations of these populations were compared to experimentally derived ranges for rabbit ventricular myocytes. 1,352 parameter sets for the Shannon model and 779 parameter sets for the Mahajan model yielded action potential duration within the experimental range, demonstrating that a wide array of ionic conductance values can be used to simulate a physiological rabbit ventricular action potential. Furthermore, by using clutter-based dimension reordering, a technique that allows visualisation of multi-dimensional spaces in two dimensions, the interaction of current conductances and their relative importance to the ventricular action potential at different cycle lengths were revealed. Overall, this work represents an important step towards a better understanding of the role that variability in current conductances may play in experimentally