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  1. 76 FR 59167 - Siemens Medical Solutions USA, Inc., Oncology Care Systems Division, Concord, CA; Siemens Medical...

    Science.gov (United States)

    2011-09-23

    ..., Concord, CA; Siemens Medical Solutions USA, Inc., Global Services/Supply Chain Management Including.../Supply Chain Management. These employees provided support for the supply of information technology...,158) and Siemens Medical Solutions USA, Inc., Global Services/Supply Chain Management,...

  2. USA

    DEFF Research Database (Denmark)

    Nedergaard, Peter

    http://www.systime.dk/ungdomsuddannelser/almen-studieforberedelse/usa-en-grundbog-i-politik-og-okonomi.html......http://www.systime.dk/ungdomsuddannelser/almen-studieforberedelse/usa-en-grundbog-i-politik-og-okonomi.html...

  3. Three-Dimensional Velocity Structure of The Geysers Geothermal Field, CA, USA

    Science.gov (United States)

    Gritto, R.; Yoo, S.

    2012-12-01

    The aim of our project is to understand the relationship between geothermal operations and medium size earthquakes (M>3) at The Geysers Geothermal Reservoir, CA, USA. To reach that goal we have devised an approach combining 4-D seismic characterization of the reservoir structure, full moment tensor analysis of the source rupture processes, geomechanical modeling of the reservoir stresses and temperatures and seismic hazard analyses. In our presentation, we will present results based on seismic data collected by the Lawrence Berkeley National Laboratory with a 34-station seismic network from 2003 through present. Specifically, we will present 3-D P- and S-wave velocity structure of the reservoir for each year of data availability and investigate temporal changes between different epochs. The spatial pattern of temporal velocity changes is subsequently correlated to the available injection and production data to investigate the cause for the observed velocity changes.

  4. Virulence Strategies of the Dominant USA300 Lineage of Community Associated Methicillin Resistant Staphylococcus aureus (CA-MRSA)

    Science.gov (United States)

    Thurlow, Lance R.; Joshi, Gauri S.; Richardson, Anthony R.

    2014-01-01

    Methicillin-Resistant Staphylococcus aureus (MRSA) poses a serious threat to worldwide health. Historically, MRSA clones have strictly been associated with hospital settings and most hospital-associated MRSA (HA-MRSA) disease resulted from a limited number of virulent clones. Recently, MRSA has spread into the community causing disease in otherwise healthy people with no discernible contact with healthcare environments. These community-associated (CA-MRSA) are phylogenetically distinct from traditional HA-MRSA clones and CA-MRSA strains seem to exhibit hyper virulence and more efficient host:host transmission. Consequently, CA-MRSA clones belonging to the USA300 lineage have become dominant sources of MRSA infections in North America. The rise of this successful USA300 lineage represents an important step in the evolution of emerging pathogens and a great deal of effort has been exerted to understand how these clones evolved. Here we review much of the recent literature aimed at illuminating the source of USA300 success and broadly categorize these findings into three main categories: newly acquired virulence genes, altered expression of common virulence determinants and alterations in protein sequence that increase fitness. We argue that none of these evolutionary events alone account for the success of USA300, but rather their combination may be responsible for the rise and spread of CA-MRSA. PMID:22309135

  5. Importance of the global regulators Agr and SaeRS in the pathogenesis of CA-MRSA USA300 infection.

    Directory of Open Access Journals (Sweden)

    Christopher P Montgomery

    Full Text Available CA-MRSA infection, driven by the emergence of the USA300 genetic background, has become epidemic in the United States. USA300 isolates are hypervirulent, compared with other CA- and HA-MRSA strains, in experimental models of necrotizing pneumonia and skin infection. Interestingly, USA300 isolates also have increased expression of core genomic global regulatory and virulence factor genes, including agr and saeRS. To test the hypothesis that agr and saeRS promote the observed hypervirulent phenotype of USA300, isogenic deletion mutants of each were constructed in USA300. The effects of gene deletion on expression and protein abundance of selected downstream virulence genes were assessed by semiquantitative real-time reverse-transcriptase PCR (qRT-PCR and western blot, respectively. The effects of gene deletion were also assessed in mouse models of necrotizing pneumonia and skin infection. Deletion of saeRS, and, to a lesser extent, agr, resulted in attenuated expression of the genes encoding α-hemolysin (hla and the Panton-Valentine leukocidin (lukSF-PV. Despite the differences in hla transcription, the toxin was undetectable in culture supernatants of either of the deletion mutants. Deletion of agr, but not saeRS, markedly increased the expression of the gene encoding protein A (spa, which correlated with increased protein abundance. Each deletion mutant demonstrated significant attenuation of virulence, compared with wild-type USA300, in mouse models of necrotizing pneumonia and skin infection. We conclude that agr and saeRS each independently contribute to the remarkable virulence of USA300, likely by means of their effects on expression of secreted toxins.

  6. Production and Injection Induced Changes at The Geysers Geothermal Field, CA, USA

    Science.gov (United States)

    Gritto, R.; Jarpe, S.; Boyle, K. L.; Hutchings, L. J.

    2011-12-01

    Induced seismicity related to the exploitation of geothermal fields has caused concern and objection from the public against the operation of geothermal reservoirs in close proximity to population centers. Production at the EGS sites in Basel (Switzerland) was stopped after renewed seismicity caused concern and objection from the public in the city. A planned expansion of the EGS site in Soultz-sous-forêt (France) was suspended after attempts to generate increased permeability through hydrofracturing of the reservoir rock generated an increase in seismicity. As a consequence of these concerns and objections it becomes imperative to understand the differences between naturally occurring and induced events and their relationship to induced stress changes in the reservoir if sustained generation of geothermal energy is the goal. We will address seismicity trends at The Geysers Geothermal Reservoir, CA USA, to understand the role of historical seismicity associated with past injection of water and/or production of steam. The paper will present results of time-lapse tomography to evaluate and quantify temporal changes of the physical parameters in the reservoir. Seismic data collected by the Lawrence Berkeley National Lab (LBNL) seismic network from 2003 through present, were analyzed to delineate regions where compressional and shear-wave velocities indicate changes in reservoir properties.

  7. Rare-earth metal prices in the USA ca. 1960 to 1994

    Science.gov (United States)

    Hedrick, James B.

    1997-01-01

    Rare-earth metal prices were compiled from the late 1950s and early 1960s through 1994. Although commercial demand for rare-earth metals began in 1908, as the alloy mischmetal, commercial quantities of a wide range of individual rare-earth metals were not available until the late 1950s. The discovery of a large, high-grade rare-earth deposit at Mountain Pass. CA, USA, in 1949, was significant because it led to the production of commercial quantities or rare-earth elements that reduced prices and encouraged wider application of the materials. The availability of ore from Mountain Pass, and other large rare-earth deposits, especially those in Australia and China, has provided the world with abundant resources for rare-earth metal production. This availability, coupled with improved technology from Government and private-sector metallurgical research, has resulted in substantial decreases in rare-earth metal prices since the late 1950s and early 1960s. Price series for the individual rare-earth metals (except promethium) are quoted on a kilogram basis from the late 1950s and early 1960s through 1994. Prices are given in US dollars on an actual and constant dollar basis. Industrial and economic factors affecting prices during this time period are examined.

  8. Stable isotopes, Sr/Ca, and Mg/Ca in biogenic carbonates from Petaluma Marsh, northern California, USA

    Energy Technology Data Exchange (ETDEWEB)

    Ingram, B.L.; De Deckker, P.; Chivas, A.R.; Conrad, M.E.; Byrne, A.R.

    2004-10-19

    Stable isotope ({sup 18}O/{sup 16}O and {sup 13}C/{sup 12}C) and minor-element compositions (Sr/Ca and Mg/Ca ratios) of ostracodes and gastropods separated from marsh sediments from San Francisco Bay, Northern California, were used to reconstruct paleoenvironmental changes in Petaluma Marsh over the past 700 yr. The value of {delta}{sup 18}O in the marsh carbonates reflects changes in freshwater inflow, evaporation, and temperature. Mg/Ca and Sr/Ca in ostracode calcite reflect changes in both freshwater inflow and temperature, although primarily reflect temperature changes in the salinity range of about 10-35 {per_thousand}. Ostracode {delta}{sup 18}O values show a gradual increase by 5 {per_thousand} between 500 yr BR and the present, probably reflecting rising sea level and increased evaporation in the marsh. Superimposed on this trend are higher frequency Mg/Ca and {delta}{sup 18}O variations (3-4 {per_thousand}), probably reflecting changes in freshwater inflow and evaporation. A period of low Mg/Ca occurred between about 100-300 cal yr BP, suggesting wetter and cooler conditions during the Little Ice Age. Higher Mg/Ca ratios occurred 600-700 cal yr BP, indicating drier and warmer conditions during the end of the Medieval Warm Period. Both ostracode and gastropod {delta}{sup 13}C values decrease up-core, reflecting decomposition of marsh vegetation, which changes from C{sub 4} ({delta}{sup 13}C {approx} -12{per_thousand}) to CAM ({delta}{sup 13}C = -26 {per_thousand})-type vegetation over time.

  9. Reservoir Changes Derived from Seismic Observations at The Geysers Geothermal Field, CA, USA

    Science.gov (United States)

    Gritto, R.; Jarpre, S.

    2012-04-01

    Induced seismicity associated with the exploitation of geothermal fields is used as a tool to characterize and delineate changes associated with injection and production of fluids from the reservoir. At the same time public concern of felt seismicity has led to objections against the operation of geothermal reservoirs in close proximity to population centers. Production at the EGS sites in Basel (Switzerland) was stopped after renewed seismicity caused concern and objection from the public in the city. Operations in other geothermal reservoirs had to be scaled back or interrupted due to an unexpected increase in seismicity (Soultz-sous-forêt, France, Berlín, El Salvador). As a consequence of these concerns and in order to optimize the use of induced seismicity for reservoir engineering purposes, it becomes imperative to understand the relationship between seismic events and stress changes in the reservoir. We will address seismicity trends at The Geysers Geothermal Reservoir, CA USA, to understand the role of historical seismicity associated with past injection of water and/or production of steam. Our analysis makes use of a comprehensive database of earthquakes and associated phase arrivals from 2004 to 2011. A high-precision sub-set of the earthquake data was selected to analyze temporal changes in seismic velocities and Vp/Vs-ratio throughout the whole reservoir. We find relatively low Vp/Vs values in 2004 suggestive of a vapor dominated reservoir. With passing time, however, the observed temporal increase in Vp/Vs, coupled with a decrease in P- and S-wave velocities suggests the presence of fluid-filled fractured rock. Considering the start of a continuous water injection project in 2004, it can be concluded that the fluid saturation of the reservoir has successfully recovered. Preliminary results of 3-D velocity inversions of seismic data appear to corroborate earlier findings that the lowest Vp/Vs estimates are observed in the center of the reservoir

  10. Climate and hillslope degradation vary in concert; 85 ka to present, eastern Sierra Nevada, CA, USA

    Science.gov (United States)

    Madoff, Risa D.; Putkonen, Jaakko

    2016-08-01

    Degradation in the landscape results when the interactions of climate, substrate, and biota dislodge and transport sediment that is mantling landforms. Rates of degradation through time control landform stability and resiliency. Therefore, records of past degradation rates can be used to inform us on how a given landscape responded to significant changes in past climates. For example, climate has varied at many temporal scales, and some of the largest recent shifts enabled the glacial advances and retreats in time scales of 20-100 ka. Therefore, it is reasonable to expect that the rate of landscape degradation has also varied at similar time scales. However, the general hillslope diffusion equation that is commonly used to model cross-profiles of hillslopes on time scales of thousands to tens of thousands of years typically relies on a constant and optimized rate parameter to generate a model cross-profile approximating the current observed landform cross-profile. Using a time-varying diffusivity parameter, we generated three separate degradation scenarios for the Mono Basin moraine in the eastern Sierra Nevada, CA, USA, in order to assess the potential impact of varying past climates on sediment transport. We used published paleoclimate records in the study area and modern rates of surface degradation from climates that correspond broadly to those paleoclimates. The results indicate that, in this case, the climate driven and, therefore, time-dependent degradation model produces a good fit between the modeled and observed landform profiles. Results showed that, when the surface elevations of the reference case (constant optimized diffusivity) were compared through time to the surface elevations of the time-dependent model, the differences were relatively small. The largest deviation was found to occur during the Last Glacial Maximum (LGM). We found that for investigations into the geological effects of climate change in glacial and polar regions, the use of time

  11. Elevation dependent sensitivity of northern hardwoods to Ca addition at Hubbard Brook Experimental Forest, NH USA

    Science.gov (United States)

    Rakesh Minocha; Stephanie Long; Palaniswamy Thangavel; Subhash C. Minocha; Christopher Eagar; Charles T. Driscoll

    2010-01-01

    Acidic deposition has caused a depletion of calcium (Ca) in the northeastern forest soils. Wollastonite (Ca silicate) was added to watershed 1 (WS1) at the Hubbard Brook Experimental Forest (HBEF) in 1999 to evaluate its effects on various functions of the HBEF ecosystem. The effects of Ca addition on foliar soluble (extractable in 5% HClO4) ions...

  12. Järelkajad Eesti presidendi visiidist USA-sse

    Index Scriptorium Estoniae

    2006-01-01

    Töövisiit Ameerika Ühendriikidesse 17.-21.01.2006. Ülevaade president Arnold Rüütli USA-vsiidist, kohtumisest San Francisco ja Sunnyvale'i linnapeadega, investor Steve Jürvetsoniga, kohalike väliseestlastega, külaskäigust Silicon Valley tehnoloogiaettevõtetesse, California Ülikooli biotehnoloogia uurimiskeskusesse

  13. Simultaneous Ka-Band Site Characterization: Goldstone, CA, White Sands, NM, and Guam, USA

    Science.gov (United States)

    Acosta, Roberto; Morse, Jacquelynne; Zemba, Michael; Nessel, James; Morabito, David; Caroglanian, Armen

    2011-01-01

    To statistically characterize atmospheric effects on Ka-band links at NASA operational sites, NASA has constructed site test interferometers (STI s) which directly measure the tropospheric phase stability and rain attenuation. These instruments observe an unmodulated beacon signal broadcast from a geostationary satellite (e.g., Anik F2) and measure the phase difference between the signals received by the two antennas and its signal attenuation. Three STI s have been deployed so far: the first one at the NASA Deep Space Network Tracking Complex in Goldstone, California (May 2007); the second at the NASA White Sands Complex, in Las Cruses, New Mexico (February 2009); and the third at the NASA Tracking and Data Relay Satellite (TDRS) Remote Ground Terminal (GRGT) complex in Guam (May 2010). Two station-years of simultaneous atmospheric phase fluctuation data have been collected at Goldstone and White Sands, while one year of data has been collected in Guam. With identical instruments operating simultaneously, we can directly compare the phase stability and rain attenuation at the three sites. Phase stability is analyzed statistically in terms of the root-mean-square (rms) of the tropospheric induced time delay fluctuations over 10 minute blocks. For two years, the time delay fluctuations at the DSN site in Goldstone, CA, have been better than 2.5 picoseconds (ps) for 90% of the time (with reference to zenith), meanwhile at the White Sands, New Mexico site, the time delay fluctuations have been better than 2.2 ps with reference to zenith) for 90% of time. For Guam, the time delay fluctuations have been better than 12 ps (reference to zenith) at 90% of the time, the higher fluctuations are as expected from a high humidity tropical rain zone. This type of data analysis, as well as many other site quality characteristics (e.g., rain attenuation, infrastructure, etc.) will be used to determine the suitability of all the sites for NASA s future communication services at Ka-band.

  14. Application of the Hyperspectral Imager for the Coastal Ocean to Phytoplankton Ecology Studies in Monterey Bay, CA, USA

    Directory of Open Access Journals (Sweden)

    John P. Ryan

    2014-01-01

    Full Text Available As a demonstrator for technologies for the next generation of ocean color sensors, the Hyperspectral Imager for the Coastal Ocean (HICO provides enhanced spatial and spectral resolution that is required to understand optically complex aquatic environments. In this study we apply HICO, along with satellite remote sensing and in situ observations, to studies of phytoplankton ecology in a dynamic coastal upwelling environment—Monterey Bay, CA, USA. From a spring 2011 study, we examine HICO-detected spatial patterns in phytoplankton optical properties along an environmental gradient defined by upwelling flow patterns and along a temporal gradient of upwelling intensification. From a fall 2011 study, we use HICO’s enhanced spatial and spectral resolution to distinguish a small-scale “red tide” bloom, and we examine bloom expansion and its supporting processes using other remote sensing and in situ data. From a spectacular HICO image of the Monterey Bay region acquired during fall of 2012, we present a suite of algorithm results for characterization of phytoplankton, and we examine the strengths, limitations, and distinctions of each algorithm in the context of the enhanced spatial and spectral resolution.

  15. The remarkable occurrence of large rainfall-induced debris flows at two different locations on July 12, 2008, Southern Sierra Nevada, CA, USA

    Science.gov (United States)

    DeGraff, J.V.; Wagner, D.L.; Gallegos, A.J.; DeRose, M.; Shannon, C.; Ellsworth, T.

    2011-01-01

    On July 12, 2008, two convective cells about 155 km apart produced a brief period of intense rainfall triggering large debris flows in the southern Sierra Nevada. The northernmost cell was centered over Oak Creek Canyon, an east-flowing drainage, and its tributaries near Independence, CA, USA. About 5:00 P.M., debris flows passed down the South Fork and North Fork of Oak Creek to merge into a large single feature whose passage affected the historic Mt. Whitney Fish hatchery and blocked California State Highway 395. At about the same time, the southernmost cell was largely centered over Erskine Creek, a main tributary of the west-flowing Kern River. Debris flows issued from several branches to coalesce into a large debris flow that passed along Erskine Creek, through the town of Lake Isabella, CA, USA and into the Kern River. It was observed reaching Lake Isabella about 6:30 P.M. Both debris flows caused significant disruption and damage to local communities. ?? 2011 Springer-Verlag.

  16. Ca, Sr, O and D isotope approach to defining the chemical evolution of hydrothermal fluids: Example from Long Valley, CA, USA

    Science.gov (United States)

    Brown, Shaun T.; Kennedy, B. Mack; DePaolo, Donald J.; Hurwitz, Shaul; Evans, William C.

    2013-12-01

    We present chemical and isotopic data for fluids, minerals and rocks from the Long Valley meteoric-hydrothermal system. The samples encompass the presumed hydrothermal upwelling zone in the west moat of the caldera, the Casa Diablo geothermal field, and a series of wells defining a nearly linear, ∼16 km long, west-to-east trend along the likely fluid flow path. Fluid samples were analyzed for the isotopes of water, Sr, and Ca, the concentrations of major cations and anions, alkalinity, and total CO2. Water isotope data conform to trends documented in earlier studies, interpreted as indicating a single hydrothermal fluid mixing with local groundwater. Sr isotopes show subtle changes along the flow path, which requires rapid fluid flow and minimal reaction between the channelized fluids and the wallrocks. Sr and O isotopes are used to calculate fracture spacing using a dual porosity model. Calculated fracture spacing and temperature data for hydrothermal fluids indicate the system is (approximately) at steady-state. Correlated variations among total CO2, and the concentration and isotopic composition of Ca suggest progressive fluid degassing (loss of CO2), which drives calcite precipitation as the fluid flows west-to-east and cools. The shifts in Ca isotopes require that calcite precipitated at temperatures of 150-180 °C is fractionated by ca. -0.3‰ to -0.5‰ relative to aqueous species. Our data are the first evidence that Ca isotopes undergo kinetic fractionation at high temperatures (>100 °C) and can be used to trace calcite precipitation along hydrothermal fluid flow paths.

  17. Occurrence of wide-chain Ca-pyriboles as primary crystals in the Salton Sea Geothermal Field, California, USA

    Science.gov (United States)

    Yau, Yu-Chyi; Peacor, Donald R.; Essene, Eric J.

    1986-09-01

    Amphiboles and pyroxenes occurring in the Salton Sea Geothermal Field were found to contain coherent intergrowths of chain silicates with other than double and single chain widths by using transmission and analytical electron microscopy. Both occur in the biotite zone at the temperature (depth) interval of 310° C (1,060 m) to 330° C (1,547m) which approximately corresponds to temperatures of the greenschist facies. The amphiboles occur as euhedral fibrous crystals occupying void space and are composed primarily of irregularly alternating (010) slabs of double or triple chains, with rare quadruple and quintuple chains. Primary crystallization from solution results in euhedral crystals. Clinopyroxenes formed mainly as a porefilling cement and subordinately as prismatic crystals coexisting with fibrous amphiboles. Fine lamellae of double and triple chains are irregularly intercalated with pyroxene. AEM analyses yield formulae (Ca1.8Mg2.9Fe1.9Mn0.1) Si8O21.8(OH)1.8 (310° C) and (Ca2.0Fe2.5Mg2.3) Si8O21.8 (OH)2.0 (330° C) for amphiboles and (Ca1.1Fe0.6Mg0.3) Si2O6 for clinopyroxene. Thermodynamic calculations at Pfluid=100 bar of equilibrium reactions of (1) 3 chlorite +10 calcite + 21 quartz = 3 actinolite + 2 clinozoisite + 8 H2O + 10 CO2 and (2) actinolite+ 3 calcite+ 2 quartz = 5 clinopyroxene + H2O + 3 CO2 using Mg-end member phases indicate that formation of amphibole and pyroxene require very water-rich conditions (X_{CO_2 } < 0.06) at temperatures below 330° C.

  18. Sunnyvale Marine Climate Deep Retrofit

    Energy Technology Data Exchange (ETDEWEB)

    German, A. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Siddiqui, A. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States); Dakin, B. [Alliance for Residential Building Innovation (ARBI), Davis, CA (United States)

    2014-11-01

    The Alliance for Residential Building Innovation (ARBI) and Allen Gilliland of One Sky Homes collaborated on a marine climate retrofit project designed to meet both Passive House (PH) and Building America program standards. The scope included sealing, installing wall, roof and floor insulation (previously lacking), replacing windows, upgrading the heating and cooling system, and installing mechanical ventilation.

  19. Sunnyvale Marine Climate Deep Retrofit

    Energy Technology Data Exchange (ETDEWEB)

    German, A.; Siddiqui, A.; Dakin, B.

    2014-11-01

    The Alliance for Residential Building Innovation (ARBI) and Allen Gilliland of One Sky Homes collaborated on a marine climate retrofit project designed to meet both Passive House (PH) and Building America (BA) program standards. The scope included sealing, installing wall, roof and floor insulation (previously lacking), replacing windows, upgrading the heating and cooling system, and installing.

  20. Sedimentary organic biomarkers suggest detrimental effects of PAHs on estuarine microbial biomass during the 20th century in San Francisco Bay, CA, USA

    Science.gov (United States)

    Nilsen, Elena B.; Rosenbauer, Robert J.; Fuller, Christopher C.; Jaffe, Bruce E.

    2014-01-01

    Hydrocarbon contaminants are ubiquitous in urban aquatic ecosystems, and the ability of some microbial strains to degrade certain polycyclic aromatic hydrocarbons (PAHs) is well established. However, detrimental effects of petroleum hydrocarbon contamination on nondegrader microbial populations and photosynthetic organisms have not often been considered. In the current study, fatty acid methyl ester (FAME) biomarkers in the sediment record were used to assess historical impacts of petroleum contamination on microbial and/or algal biomass in South San Francisco Bay, CA, USA. Profiles of saturated, branched, and monounsaturated fatty acids had similar concentrations and patterns downcore. Total PAHs in a sediment core were on average greater than 20× higher above ∼200 cm than below, which corresponds roughly to the year 1900. Isomer ratios were consistent with a predominant petroleum combustion source for PAHs. Several individual PAHs exceeded sediment quality screening values. Negative correlations between petroleum contaminants and microbial and algal biomarkers – along with high trans/cis ratios of unsaturated FA, and principle component analysis of the PAH and fatty acid records – suggest a negative impacts of petroleum contamination, appearing early in the 20th century, on microbial and/or algal ecology at the site.

  1. Hydrogeologic Heterogeneity Enhances the Transfer of Salt Toward the High-Quality Deep Aquifers of the Western San Joaquin Valley (CA, USA)

    Science.gov (United States)

    Henri, C. V.; Harter, T.; Zhang, H.

    2016-12-01

    Increasing anthropogenic and drought stresses lead salinity to be of serious concern within regard to with the sustainability of regional groundwater quality. Agricultural basins of the Central Valley, CA (USA) are, and will continue to be, impacted by salinity issues in the coming future decades and or centuries. The aquifer system below the Western San Joaquin Valley is characterized by a shallow unconfined aquifer with high salinity overlying high quality semi-confined and deeper confined aquifers. A key challenge in the area is to predict if, when and how water traveling from the the low-quality shallow groundwater will reach and degrade the deeper semi-confined and confined aquifers. Previous studies, accounting for a simplified description of the aquifer hydraulic properties in their flow model, concluded that saline shallow groundwater would need 200-400 years to reach the semi-confined aquifer and 250-600 years to impact the deeper confined aquifer. However, well known heterogeneities in aquifer hydraulic properties significantly impact contaminant transport due to preferential flow paths and increased dispersion. Our study aims to (1) better understand the impact of heterogeneous hydraulic properties on the distribution of travel times from non-point source contamination, and (2) reassess the temporal scale of salt transfer into the deeper aquifers of the Western San Joaquin Valley. A detailed non-stationary geostatistical model was developed to describe the spatial variability of hydrofacies in great detail at the basin scale. The hydraulic properties corresponding to each hydrofacies are then calibrated in order to reproduce water fluxes previously modeled and calibrated. Subsequently, we use the random-walk particle tracking method to simulate the advective-dispersive transport of salt throughout the study area from a non-point source zone represented by the entire top layer of the model. The flux concentrations of solute crossing a series of monitoring

  2. Complete-genome sequencing elucidates outbreak dynamics of CA-MRSA USA300 (ST8-spa t008) in an academic hospital of Paramaribo, Republic of Suriname.

    Science.gov (United States)

    Sabat, Artur J; Hermelijn, Sandra M; Akkerboom, Viktoria; Juliana, Amadu; Degener, John E; Grundmann, Hajo; Friedrich, Alexander W

    2017-01-20

    We report the investigation of an outbreak situation of methicillin-resistant Staphylococcus aureus (MRSA) that occurred at the Academic Hospital Paramaribo (AZP) in the Republic of Suriname from April to May 2013. We performed whole genome sequencing with complete gap closure for chromosomes and plasmids on all isolates. The outbreak involved 12 patients and 1 healthcare worker/nurse at the AZP. In total 24 isolates were investigated. spa typing, genome-wide single nucleotide polymorphism (SNP) analysis, ad hoc whole genome multilocus sequence typing (wgMLST), stable core genome MLST (cgMLST) and in silico PFGE were used to determine phylogenetic relatedness and to identify transmission. Whole-genome sequencing (WGS) showed that all isolates were members of genomic variants of the North American USA300 clone. However, WGS revealed a heterogeneous population structure of USA300 circulating at the AZP. We observed up to 8 SNPs or up to 5 alleles of difference by wgMLST when the isolates were recovered from different body sites of the same patient or if direct transmission between patients was most likely. This work describes the usefulness of complete genome sequencing of bacterial chromosomes and plasmids providing an unprecedented level of detail during outbreak investigations not being visible by using conventional typing methods.

  3. Complete-genome sequencing elucidates outbreak dynamics of CA-MRSA USA300 (ST8-spa t008) in an academic hospital of Paramaribo, Republic of Suriname

    Science.gov (United States)

    Sabat, Artur J.; Hermelijn, Sandra M.; Akkerboom, Viktoria; Juliana, Amadu; Degener, John E.; Grundmann, Hajo; Friedrich, Alexander W.

    2017-01-01

    We report the investigation of an outbreak situation of methicillin-resistant Staphylococcus aureus (MRSA) that occurred at the Academic Hospital Paramaribo (AZP) in the Republic of Suriname from April to May 2013. We performed whole genome sequencing with complete gap closure for chromosomes and plasmids on all isolates. The outbreak involved 12 patients and 1 healthcare worker/nurse at the AZP. In total 24 isolates were investigated. spa typing, genome-wide single nucleotide polymorphism (SNP) analysis, ad hoc whole genome multilocus sequence typing (wgMLST), stable core genome MLST (cgMLST) and in silico PFGE were used to determine phylogenetic relatedness and to identify transmission. Whole-genome sequencing (WGS) showed that all isolates were members of genomic variants of the North American USA300 clone. However, WGS revealed a heterogeneous population structure of USA300 circulating at the AZP. We observed up to 8 SNPs or up to 5 alleles of difference by wgMLST when the isolates were recovered from different body sites of the same patient or if direct transmission between patients was most likely. This work describes the usefulness of complete genome sequencing of bacterial chromosomes and plasmids providing an unprecedented level of detail during outbreak investigations not being visible by using conventional typing methods. PMID:28106148

  4. Liquefaction Hazard Maps for Three Earthquake Scenarios for the Communities of San Jose, Campbell, Cupertino, Los Altos, Los Gatos, Milpitas, Mountain View, Palo Alto, Santa Clara, Saratoga, and Sunnyvale, Northern Santa Clara County, California

    Science.gov (United States)

    Holzer, Thomas L.; Noce, Thomas E.; Bennett, Michael J.

    2008-01-01

    Maps showing the probability of surface manifestations of liquefaction in the northern Santa Clara Valley were prepared with liquefaction probability curves. The area includes the communities of San Jose, Campbell, Cupertino, Los Altos, Los Gatos Milpitas, Mountain View, Palo Alto, Santa Clara, Saratoga, and Sunnyvale. The probability curves were based on complementary cumulative frequency distributions of the liquefaction potential index (LPI) for surficial geologic units in the study area. LPI values were computed with extensive cone penetration test soundings. Maps were developed for three earthquake scenarios, an M7.8 on the San Andreas Fault comparable to the 1906 event, an M6.7 on the Hayward Fault comparable to the 1868 event, and an M6.9 on the Calaveras Fault. Ground motions were estimated with the Boore and Atkinson (2008) attenuation relation. Liquefaction is predicted for all three events in young Holocene levee deposits along the major creeks. Liquefaction probabilities are highest for the M7.8 earthquake, ranging from 0.33 to 0.37 if a 1.5-m deep water table is assumed, and 0.10 to 0.14 if a 5-m deep water table is assumed. Liquefaction probabilities of the other surficial geologic units are less than 0.05. Probabilities for the scenario earthquakes are generally consistent with observations during historical earthquakes.

  5. Increases in the climate change adaption effectiveness and availability of vegetation across a coastal to desert climate gradient in metropolitan Los Angeles, CA, USA.

    Science.gov (United States)

    Tayyebi, Amin; Jenerette, G Darrel

    2016-04-01

    Urbanization has increased heat in the urban environment, with many consequences for human health and well-being. Managing climate change in part through increasing vegetation is desired by many cities to mitigate current and future heat related issues. However, little information is available on what influences the current effectiveness and availability of vegetation for local cooling. In this study, we identified the variation in the interacting relationships among vegetation (normalized difference vegetation index), socioeconomic status (neighborhood income), elevation and land surface temperature (LST) to identify how vegetation based surface cooling services change throughout the pronounced coastal to desert climate gradient of the Los Angeles, CA metropolitan region, a megacity of >18 million residents. A key challenge for understanding variation in vegetation as a climate change adaptation tool spanning neighborhood to megacity scales is developing new "big data" analytical tools. We used structural equation modeling (SEM) to quantify the interacting relationships among socio-economic status data obtained from government census data, elevation and new LST and vegetation data obtained from an airborne imaging campaign conducted in 2013 for the urban and suburban areas across a series of fifteen climate zones. Vegetation systematically increased in cooling effectiveness from 6.06 to 31.77 degrees with increasing distance from the coast. Vegetation and neighborhood income were positively correlated throughout all climate zones with a peak in the relationship occurring near 25km from the coast. Because of the interaction between these two relationships, we also found that higher income neighborhoods were cooler and that this effect peaked at about 30km from the coast. These results show the availability and effectiveness of vegetation on the local climate varies tremendously throughout the Los Angeles, CA metropolitan area. Further, using the more inland climate

  6. Trophic transfer and effects of DDT in male hornyhead turbot (Pleuronichthys verticalis) from Palos Verdes Superfund site, CA (USA) and comparisons to field monitoring.

    Science.gov (United States)

    Crago, Jordan; Xu, Elvis Genbo; Kupsco, Allison; Jia, Fang; Mehinto, Alvine C; Lao, Wenjian; Maruya, Keith A; Gan, Jay; Schlenk, Daniel

    2016-06-01

    High concentrations of DDT and metabolites (ΣDDT) have been detected in sediment and the demersal flatfish hornyhead turbot (Pleuronichtys verticalis) collected from Palos Verdes (PV), California, USA, a site contaminated with over 100 metric tons of DDT throughout 1960s-70s. This study was conducted to assess the transfer of ΣDDT from PV-sediment into polychaetes (Neanthes arenaceodentata) and hornyhead turbot, and to investigate if the responses in turbots from two different laboratory exposures mimic those in turbots caught in PV (PV-turbot). Turbot fed PV-sediment-contaminated polychaete for 7 days had liver concentrations of ΣDDT similar to PV-turbot. After 28 days, ΣDDT also accumulated in livers of turbot gavaged with a ΣDDT mixture. In vitro cell bioassays indicated significant increases of 17β-estradiol equivalents (EEQ) in turbot bile extracts as compared to the control in the 7-day study. These responses corresponded to those measured in PV-fish. Glucocorticoid receptor (GR), anti-androgen receptor (anti-AR), estrogen receptor (ER) or aryl hydrocarbon receptor (AhR) activities were also observed in extracts of PV-sediment, and PV-sediment-exposed worm. Anti-AR, AhR and GR activities were significantly higher in PV-sediment than reference sediment (San Diego, SD). Higher transcripts of hepatic VTG, ERα and ERβ were found in PV-turbot than SD-turbot, but were unaltered in fish exposed to sediment-contaminated worms for the 7-day study. In contrast, liver extracts from the 28-day treatment of ΣDDT showed lower EEQ but similar hepatic VTG and ERβ transcripts relative to those of PV-turbot. These data indicated that trophic transfer of sediment-associated DDT in 7-day exposures corresponded to field measurements of DDT residues and in vitro ER bioactivities, but failed to mimic in vivo biological effects observed in field fish. In contrast, treatment with ΣDDT alone for 28 days mimicked in vivo biological effects of DDTs in PV fish, but did not

  7. Integrated thermal infrared imaging and Structure-from-Motion photogrametry to map apparent temperature and radiant hydrothermal heat flux at Mammoth Mountain, CA USA

    Science.gov (United States)

    Lewis, Aaron; George Hilley,; Lewicki, Jennifer L.

    2015-01-01

    This work presents a method to create high-resolution (cm-scale) orthorectified and georeferenced maps of apparent surface temperature and radiant hydrothermal heat flux and estimate the radiant hydrothermal heat emission rate from a study area. A ground-based thermal infrared (TIR) camera was used to collect (1) a set of overlapping and offset visible imagery around the study area during the daytime and (2) time series of co-located visible and TIR imagery at one or more sites within the study area from pre-dawn to daytime. Daytime visible imagery was processed using the Structure-from-Motion photogrammetric method to create a digital elevation model onto which pre-dawn TIR imagery was orthorectified and georeferenced. Three-dimensional maps of apparent surface temperature and radiant hydrothermal heat flux were then visualized and analyzed from various computer platforms (e.g., Google Earth, ArcGIS). We demonstrate this method at the Mammoth Mountain fumarole area on Mammoth Mountain, CA. Time-averaged apparent surface temperatures and radiant hydrothermal heat fluxes were observed up to 73.7 oC and 450 W m-2, respectively, while the estimated radiant hydrothermal heat emission rate from the area was 1.54 kW. Results should provide a basis for monitoring potential volcanic unrest and mitigating hydrothermal heat-related hazards on the volcano.

  8. Evaporative Evolution of a Na-Cl-NO3-K-Ca-SO4-Mg-Si Brine at 95(degree)C: Experiments and Modeling relevant to Yucca Mountain, Nevada, USA

    Energy Technology Data Exchange (ETDEWEB)

    Alai, M; Sutton, M; Carroll, S A

    2004-08-24

    A synthetic Topopah Spring Tuff water representative of one type of pore water at Yucca Mountain, Nevada (USA) was evaporated at 95 C in a series of experiments to determine the geochemical controls for brines that may form on, and possibly impact upon the long-term integrity of waste containers and drip shields at the designated high-level, nuclear-waste repository. Solution chemistry, condensed vapor chemistry, and precipitate mineralogy were used to identify important chemical divides and to validate geochemical calculations of evaporating water chemistry using a high temperature Pitzer thermodynamic database. The water evolved towards a complex ''sulfate type'' brine that contained about 45 mol% Na, 40 mol% Cl, 9 mol% NO{sub 3}, 5 mol% K, and less than 1 mol% each of SO{sub 4}, Ca, Mg, {Sigma}CO{sub 2}(aq), F, and Si. All measured ions in the condensed vapor phase were below detection limits. The mineral precipitates identified were halite, anhydrite, bassanite, niter and nitratine. Trends in the solution composition and identification of CaSO{sub 4} solids suggest that fluorite, carbonate, sulfate, and magnesium-silicate precipitation control the aqueous solution composition of sulfate type waters by removing fluoride, calcium, and magnesium during the early stages of evaporation. In most cases, the high temperature Pitzer database, used by EQ3/6 geochemical code, sufficiently predicts water composition and mineral precipitation during evaporation. Predicted solution compositions are generally within a factor of two of the experimental values. The model predicts that sepiolite, bassanite, amorphous silica, calcite, halite and brucite are the solubility controlling mineral phases.

  9. FLOODPLAIN, CONTRA COSTA COUNTY, CA, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  10. Brown, C.A., D. Sharp, and T. Mochon Collura. 2016. Effect of Climate Change on Water Temperature and Attainment of Water Temperature Criteria in the Yaquina Estuary, Oregon (USA). Estuarine, Coastal and Shelf Science. 169:136-146.

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains the research described in the following publication: Brown, C.A., D. Sharp, and T. Mochon Collura. 2016. Effect of Climate Change on Water...

  11. Soil bacterial communities of a calcium-supplemented and a reference watershed at the Hubbard Brook Experimental Forest (HBEF), New Hampshire, USA

    Science.gov (United States)

    Ganapathi Sridevi; Rakesh Minocha; Swathi A. Turlapati; Katherine C. Goldfarb; Eoin L. Brodie; Louis S. Tisa; Subhash C. Minocha

    2012-01-01

    Soil Ca depletion because of acidic deposition-related soil chemistry changes has led to the decline of forest productivity and carbon sequestration in the northeastern USA. In 1999, acidic watershed (WS) 1 at the Hubbard Brook Experimental Forest (HBEF), NH, USA was amended with Ca silicate to restore soil Ca pools. In 2006, soil samples were collected from the Ca-...

  12. Parallel Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus USA300 Infection in North and South America

    OpenAIRE

    Paul J Planet; Diaz, Lorena; Kolokotronis, Sergios-Orestis; Narechania, Apurva; Reyes, Jinnethe; Xing, Galen; Rincon, Sandra; Smith, Hannah; Panesso, Diana; Ryan, Chanelle; Smith, Dylan P.; Guzman, Manuel De; Zurita, Jeannete; Sebra, Robert; Deikus, Gintaras

    2015-01-01

    Background. The community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) epidemic in the United States is attributed to the spread of the USA300 clone. An epidemic of CA-MRSA closely related to USA300 has occurred in northern South America (USA300 Latin-American variant, USA300-LV). Using phylogenomic analysis, we aimed to understand the relationships between these 2 epidemics.

  13. Robot-assisted Radical Prostatectomy: How I Do It

    Directory of Open Access Journals (Sweden)

    Cemil Uygur

    2016-06-01

    Full Text Available In this article, we describe surgical technique for robot assisted radical prostatectomy using the four-arm da Vinci robotic surgical system (SI, Intuitive Surgical, Sunnyvale, CA, USA. We have continually refined our technique to improve patient outcomes.

  14. Coblation for tonsillectomy in children: an evidence-based update on a maturing technology

    Science.gov (United States)

    Shah, Udayan K.

    2007-02-01

    Coblation technology (Arthrocare Corp., Sunnyvale, CA, USA) uses plasma-mediated ablation (PMA) for soft-tissue removal. The application of PMA for tonsillectomy has evolved since 1998 through changes in equipment, and surgical techniques. This paper reviews the evidence to date for Coblation tonsillectomy, and offers perspective on novel applications of this maturing technology.

  15. Solar Ca II K Observations

    Science.gov (United States)

    Bertello, Luca; Pevtsov, Alexei A.; Tlatov, Andrey; Singh, Jagdev

    2016-07-01

    Some of the most important archives of past and current long-term solar synoptic observations in the resonance line of Ca II K are described here. These observations are very important for understanding the state of the solar magnetism on time scales up to several decades. The first observations of this kind began in 1904 at the Kodaikanal Observatory (India), followed by similar programs at different other locations. Regular full-disk Ca II K monitoring programs started in 1915 at the Mount Wilson Observatory (USA) and in 1917 at the National Solar Observatory of Japan. Beginning in 1919 and in 1926 regular observations were taken also at the Paris-Meudon Observatory (France) and at the "Donati solar tower telescope of the Arcetri Astrophysical Observatory in Italy, respectively. In 1926 the the Astronomical Observatory of the Coimbra University in Portugal started its own program of Ca II K observations. Although some of these programs have been terminated over the years, their data archives constitute a unique resource for studies of solar variability. In the early 1970s, the National Solar Observatory (NSO) at Sacramento Peak (USA) started a new program of daily Sun-as-a-star observations in the Ca II K line. Today the NSO is continuing these observations through its Synoptic Optical Long-term Investigations of the Sun (SOLIS) facility.

  16. IBC's 21st Annual Antibody Engineering and 8th Annual Antibody Therapeutics International Conferences and 2010 Annual Meeting of the Antibody Society. December 5-9, 2010, San Diego, CA USA.

    Science.gov (United States)

    Arnett, Samantha O; Teillaud, Jean-Luc; Wurch, Theirry; Reichert, Janice M; Dunlop, Cameron; Huber, Michael

    2011-01-01

    The 21st Annual Antibody Engineering and 8th Annual Antibody Therapeutics international conferences, and the 2010 Annual Meeting of The Antibody Society, organized by IBC Life Sciences with contributions from The Antibody Society and two Scientific Advisory Boards, were held December 5-9, 2010 in San Diego, CA. The conferences were organized with a focus on antibody engineering only on the first day and a joint engineering/therapeutics session on the last day. Delegates could select from presentations that occurred in two simultaneous sessions on days 2 and 3. Day 1 included presentations on neutralizing antibodies and the identification of vaccine targets, as well as a historical overview of 20 years of phage display utilization. Topics presented in the Antibody Engineering sessions on day 2 and 3 included antibody biosynthesis, structure and stability; antibodies in a complex environment; antibody half-life; and targeted nanoparticle therapeutics. In the Antibody Therapeutics sessions on days 2 and 3, preclinical and early stage development and clinical updates of antibody therapeutics, including TRX518, SYM004, MM111, PRO140, CVX-241, ASG-5ME, U3-1287 (AMG888), R1507 and trastuzumab emtansine, were discussed, and perspectives were provided on the development of biosimilar and biobetter antibodies, including coverage of regulatory and intellectual property issues. The joint engineering/therapeutics session on the last day focused on bispecific and next-generation antibodies.

  17. Det sorte USA

    DEFF Research Database (Denmark)

    Brøndal, Jørn

    Bogen gennemgår det sorte USAs historie fra 1776 til 2016, idet grundtemaet er spændingsforholdet mellem USAs grundlæggelsesidealer og den racemæssige praksis, et spændingsforhold som Gunnar Myrdal kaldte "det amerikanske dilemma." Bogen, der er opbygget som politisk, social og racemæssig historie...

  18. Glemmer USA Afghanistan nu?

    DEFF Research Database (Denmark)

    Jakobsen, Peter Viggo

    2015-01-01

    Hvis Obamas efterfølger kan skrue den rigtige strategiske fortælling sammen så vil USA ikke forlade Afghanistan med udgangen af 2016.......Hvis Obamas efterfølger kan skrue den rigtige strategiske fortælling sammen så vil USA ikke forlade Afghanistan med udgangen af 2016....

  19. 76 FR 27662 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2011-05-12

    ... names as respondents Hewlett-Packard Company of Palo Alto, CA; Apple Inc. of Cupertino, CA; Aruba Networks, Inc. of Sunnyvale, CA; Meru Networks of Sunnyvale, CA and Ruckus Wireless of Sunnyvale, CA. The... Commission has received a complaint filed on Linex Technologies, Inc. on May 6, 2011. The complaint...

  20. USA Hire Testing Platform

    Data.gov (United States)

    Office of Personnel Management — The USA Hire Testing Platform delivers tests used in hiring for positions in the Federal Government. To safeguard the integrity of the hiring processes and ensure...

  1. Loeng USA Sisejulgeolekuministeeriumi kantslerilt

    Index Scriptorium Estoniae

    2005-01-01

    13. okt. pidas USA Sisejulgeolekuministeeriumi teaduse ja tehnoloogia kantsler dr Charles McQueary Tartu Ülikooli Tehnoloogiainstituudis loengu "Uue põlvkonna ettevõtlust suunavad ja julgeolekut edendavad tehnoloogiad"

  2. USA kunstidessant Venemaale

    Index Scriptorium Estoniae

    2007-01-01

    USA kunstnike näitus "Kolm sajandit ameerika kunsti" Moskvas Pushkini muuseumis. Eksponeeritakse Mark Rothko, Jean-Michel Basguiat', Roy Lichtensteini, Robert Rauschenbergi, Georgia O'Keefe'i, Willem de Kooningi töid

  3. USA kunstidessant Venemaale

    Index Scriptorium Estoniae

    2007-01-01

    USA kunstnike näitus "Kolm sajandit ameerika kunsti" Moskvas Pushkini muuseumis. Eksponeeritakse Mark Rothko, Jean-Michel Basguiat', Roy Lichtensteini, Robert Rauschenbergi, Georgia O'Keefe'i, Willem de Kooningi töid

  4. American Uveitis Society Meeting October 30, 1995 Marriott Marquis Hotel, Atlanta, GA, USA.

    Science.gov (United States)

    Meisler, D M; Chern, K C

    1996-01-01

    1 Retinal vascular occlusion and scleroderma. Tessler H, Flores-Guevara J, Goldstein D, Chicago, IL, USA. 2 MHC Class II antigen expression in ciliary body in spontaneous and experimental uveitis. Kalsow C, Zhavoronkova M, Dwyer A, Rochester, NY & Scottsville, NY, USA. 3 IL-10 in the vitreous of patients with intraocular lymphoma. Whitcup S, Solomon D, Nussenblatt R, Chan C-C, Bethesda, MD, USA 4 Iris juvenile xanthogranuloma studied by immunohistochemistry. Shields J, Shields C, Eagle R, DePotter P, Collins M, Philadelphia, PA, USA. 5 Outcomes analysis in with JRA-associated uveitis. Dana M-R, Merayo-Lloves J, Foster C, Boston MA, USA. 6 Persistent glaucoma secondary to periocular steroids. Akduman L, Conway M, Burchfield J, Kolker A, Black D, DelPriore L, Kaplan H, St. Louis, MO, USA 7 The use of itraconazole in ocular histoplasmosis Callanan D, Fish G, Dallas, TX, USA 8 Succesful treatment of macular hole secondary to sympathetic ophthalmia. Cano J, Diaz M, Navea A, Ruiz C, Castilla M. Barcelona, Spain. 9 HLA-DR2+ intermediate uveitis. Pulido J, Tang W, Han D, Mieler W. Milwaukee, WI, USA. 10 Vein occlusion in AIDS misdiagnosed as CMV retinitis. Park K, Marx J, Rao N. Los Angeles, CA, USA. 11 HIV-associated foveal hemorrhage. Crews K, Zimmerman P, Lohner S. Salt Lake City, UT, USA. 12 Cytomegalovirus papillitis in patients with AIDS. Patel S, Rutzen A, Marx J, Thach A, Chong L, Rao N, Los Angeles, CA, USA. 13 Recurrence rate of CMV retinitis following the ganciclovir implant and pars plans vitrectomy and silicone oil. Marx J, Thach A, Rao N, Chong L. Los Angeles, CA, USA.

  5. BYRON TRACT HYDROLOGY, CONTRA COSTA COUNTY, CA USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydrology data includes spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for the flood insurance...

  6. DCS Hydraulics Submission for Plumas County CA, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  7. Baltimaade kunsti turnee USAs

    Index Scriptorium Estoniae

    1998-01-01

    5. nov.-st USA Lõuna-Carolina osariigis Wellington B. Grey galeriis ja Jenkins Fine Art Center's 13 eesti, läti ja leedu kunstniku näitus, mis hakkab kolme aasta jooksul ringlema Ameerikas. Eksponeeritud fotokunst, video, installatsioon, joonistused. Kuraator Peeter Linnap ja Mari Laanemets peavad ettekande näituse avamisega samal ajal toimuval Fotohariduse Ühingu konverentsil

  8. Baltimaade kunsti turnee USAs

    Index Scriptorium Estoniae

    1998-01-01

    5. nov.-st USA Lõuna-Carolina osariigis Wellington B. Grey galeriis ja Jenkins Fine Art Center's 13 eesti, läti ja leedu kunstniku näitus, mis hakkab kolme aasta jooksul ringlema Ameerikas. Eksponeeritud fotokunst, video, installatsioon, joonistused. Kuraator Peeter Linnap ja Mari Laanemets peavad ettekande näituse avamisega samal ajal toimuval Fotohariduse Ühingu konverentsil

  9. The USA PATRIOT Act.

    Science.gov (United States)

    Minow, Mary; Coyle, Karen; Kaufman, Paula

    2002-01-01

    Explains the USA PATRIOT (Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism) Act, passed after the September 11 terrorist attacks, and its implications for libraries and patron records. Considers past dealings with the FBI; court orders; search warrants; wiretaps; and subpoenas. Includes:…

  10. Martel's links with USA

    Directory of Open Access Journals (Sweden)

    Trevor Shaw

    1997-01-01

    Full Text Available Of the 29% foreign members in the Société de Spéléologie, five lived in USA. They were Luella Owen (the only woman member of the Société, R. Ellsworth Cali, H.C. Hovey, E Van Epps and C. R. Blackall. E.S. Balch, though not a member, also knew Martel. These members, between them, published ten papers in Spelunca, which also reviewed their other work. The activities of these six, and their links with France, are discussed. Martel actively encouraged cave work in America, as elsewhere, and Hovey, who had been with him during the survey of Aven Armand, he knew quite well. In 1912 Martel at last visited USA himself and the barometer readings he took in Mamoth Cave to measure altitude enabled him to draw the first longitudinal section of the cave since 1835.

  11. USA-USSR protocol

    CERN Multimedia

    1970-01-01

    On 30 November the USA Atomic Energy Commission and the USSR State Committee for the Utilization of Atomic Energy signed, in Washington, a protocol 'on carrying out of joint projects in the field of high energy physics at the accelerators of the National Accelerator Laboratory (Batavia) and the Institute for High Energy Physics (Serpukhov)'. The protocol will be in force for five years and can be extended by mutual agreement.

  12. 3D point cloud data from laser scanning along the 2014 South Napa Earthquake surface rupture, California, USA

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Point cloud data collected along a 500 meter portion of the 2014 South Napa Earthquake surface rupture near Cuttings Wharf Road, Napa, CA, USA. The data include 7...

  13. Etnocentrismus v USA

    OpenAIRE

    Hronová, Jitka

    2012-01-01

    The aim of the bachelor thesis "Ethnocentrism in the USA" is to find basic forms of ethnocentrism and to identify the ones that are in the USA. The Czech and American cultures are compared in the thesis via author's research. Then the rate of ethnocentrism in the USA is evaluated. Interviewing young people gives a current trend and an expectation of future course of the ethnocentrism.

  14. Multikulturalismus v USA

    OpenAIRE

    Smejkal, Tomáš

    2014-01-01

    The objective of this Bachelor thesis is to map out the historical development of multiculturalism in the USA and to deal with the current issues of this phenomenon. For instance, this thesis deals with the process of hispanization in the USA or with the so called affirmative action in the American society. The first part of this thesis explains the term multiculturalism in theory. The second part focuses on the history of the USA and their milestones connected with the development of multicu...

  15. Tšarterkool USA-s / Johannes Kiersch

    Index Scriptorium Estoniae

    Kiersch, Johannes

    2001-01-01

    24.-27. mainì 01 toimub Tallinnas EFFE 2001 (European Forum of Freedom in Education) konverents "Haridus tänases kodanikuühiskonnas." Konverentsil esineb ka Witteni Waldorf-pedagoogika Instituudi õppejõud Johannes Kiersch. Lähemalt tema artiklist USA-s populaarsust võitvate tsharterkoolide kohta, mis on riigi- ja erakooli vahevorm

  16. Application of Ca stable isotopes to long-term changes in the Ca cycle of a Northern Hardwood forest

    Science.gov (United States)

    Kurtz, A. C.; Takagi, K.; Bailey, S. W.; Bullen, T. D.

    2015-12-01

    The Hubbard Brook Ecosystem Study (New Hampshire, USA) presents an unusual opportunity for the application of innovative isotope methods in forest biogeochemistry. Changes in biogeochemical cycling resulting from decades of acid deposition, subsequent reductions in acid deposition, and a series of experimental treatments (harvesting, Ca amendment) have been studied continuously for 60 years at this site. Importantly, researchers have archived soil, water, and vegetation samples for much of the site's history. Our work seeks to complement earlier mass balance studies of Ca cycling by measuring Ca isotope ratios on archived samples. In the first component of our study, we examined the Ca isotopic response to an experimental clearcut in the early 1980's. Earlier work showed that the clearcut promoted dramatic loss of Ca from the watershed, indicated by a 5-fold increase in streamwater Ca concentrations. The mechanism for this loss was unclear as no resolvable changes in soil Ca pools were observed. Our work shows that streamwater dissolved Ca becomes isotopically lighter as Ca concentrations increase. These data are best accounted for by an increase in Ca loss from the soil cation exchange complex. Soil exchangeable δ44Ca itself evolves towards lighter values in the years following the experimental harvest. We interpret this as replenishment of the soil exchange complex by release of isotopically light Ca from root biomass. In the second component of our study, we examine decadal-scale changes in streamwater and soil Ca in an un-manipulated biogeochemical reference watershed. Historical data from Hubbard Brook show that streamwater Ca concentrations began decreasing sharply in the early 1970's, attributed to decreased deposition of both acidity and Ca with the passage of the Clean Air Act. Preliminary data indicate no resolvable change in the average δ44Ca of streamwater, with variability mostly attributable to discharge (flowpath control). Preliminary data

  17. Safety Assessment of Advanced Imaging Sequences I: Measurements

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Rasmussen, Morten Fischer; Pihl, Michael Johannes

    2016-01-01

    distributions. The method is several orders of magnitude faster than approaches using an oscilloscope, and it also facilitates validating the emitted pressure field and the scanner’s emission sequence software. It has been implemented using the experimental SARUS scanner and the Onda AIMS III intensity...... measurement system (Onda Corporation, Sunnyvale, CA, USA). Four different sequences have been measured: a fixed focus emission, a duplex sequence containing B-mode and flow emissions, a vector flow sequence with B-mode and flow emissions in 17 directions, and finally a synthetic aperture (SA) duplex flow...... sequence. A BK8820e (BK Medical, Herlev, Denmark) convex array probe is used for the first three sequences and a BK8670 linear array probe for the SA sequence. The method is shown to give the same intensity values within 0.24% of the AIMS III Soniq 5.0 (Onda Corporation, Sunnyvale, CA, USA) commercial...

  18. TTÜ ja TÜ osalevad USA armee miljoniprojektides

    Index Scriptorium Estoniae

    2016-01-01

    TTÜ ja TÜ liitusid USA-s tegutseva meditsiinitehnoloogia ettevõtete konsortsiumiga. Nii jõuavad juhtivate Eesti kõrgkoolide teadmised USA armeesse, kes konsortsiumi kaudu innovaatilisi tooteid ja teenuseid sisse ostab

  19. TTÜ ja TÜ osalevad USA armee miljoniprojektides

    Index Scriptorium Estoniae

    2016-01-01

    TTÜ ja TÜ liitusid USA-s tegutseva meditsiinitehnoloogia ettevõtete konsortsiumiga. Nii jõuavad juhtivate Eesti kõrgkoolide teadmised USA armeesse, kes konsortsiumi kaudu innovaatilisi tooteid ja teenuseid sisse ostab

  20. Go.USA.gov URL Shortner API

    Data.gov (United States)

    General Services Administration — The Go.USA.gov REST API allows you interact with Go.USA.gov by shortening URLs, previewing long urls, and getting the number of clicks to a Go.USA.gov URL.. An API...

  1. Euroopa teadis USA salavanglaist / Tõnis Erilaid

    Index Scriptorium Estoniae

    Erilaid, Tõnis, 1943-

    2005-01-01

    USA endise välisministri Colin Powelli sõnul pole see tema sõpradele Euroopas uudiseks, et USA on viinud vange riikidesse, kus tema seadused ei kehti. USA praeguse välisministri Condoleezza Rice'i sõnul on USA vange üle kuulanud väljaspool USA-d. USA Today kirjeldab Stare Kiejkuty küla Poolas, kus arvatavasti on olnud salavangla

  2. Euroopa teadis USA salavanglaist / Tõnis Erilaid

    Index Scriptorium Estoniae

    Erilaid, Tõnis, 1943-

    2005-01-01

    USA endise välisministri Colin Powelli sõnul pole see tema sõpradele Euroopas uudiseks, et USA on viinud vange riikidesse, kus tema seadused ei kehti. USA praeguse välisministri Condoleezza Rice'i sõnul on USA vange üle kuulanud väljaspool USA-d. USA Today kirjeldab Stare Kiejkuty küla Poolas, kus arvatavasti on olnud salavangla

  3. Severe invasive methicillin-resistant S. aureus (USA300 clone infection in an Italian adolescent

    Directory of Open Access Journals (Sweden)

    Piero Valentini

    2009-12-01

    Full Text Available This report describes an uncommon presentation of invasive community-acquired methicillin-resistant S. aureus (CA-MRSA infection in an immunocompetent adolescent without any other risk factor, characterized by septicaemia, meningitis, necrotising pneumonia and deep venous thrombosis (DVT. Successful treatment was performed with linezolid, rifampicin and low-molecular-weight heparin (LMWH. MRSA molecular typing revealed the presence of Panton-Valentine leukocidin (PVL gene, and a genetic background identical to USA300 clone, an emerging aggressive CA-MRSA strain in USA and Europe.

  4. Staged Radiosurgical Ablation for Choroid Melanoma: A Case Report with Emphasis on the Role of Patient Preparation, Treatment Planning, and Precision of Delivery.

    Science.gov (United States)

    Adamczyk, Marta; Janiga, Piotr

    2016-01-01

    The aim of reporting this case of choroid melanoma of the left eye is to introduce the in-house-designed treatment planning protocol for fractionated radiosurgical ablation of an intraocular lesion. This is a clinical case with emphasis on treatment preparation and delivery using the Accuray CyberKnife Robotic Radiosurgery System (Accuray, Sunnyvale, CA, USA) for a patient immobilized with a head mask and our in-house-made eye fixation system.

  5. Estrogen and the Dietary Phytoestrogen Tesveratrol as Regulators of the Rho GTPase Rac in Breast Cancer Research

    Science.gov (United States)

    2010-06-01

    from an Olympus inverted fluorescence microscope using Metamorph software (Molecular Devices, Sunnyvale, CA, USA) and quantified from ten random...with Annexin V Cy3) from ten random microscopic fields/coverslip. Averages ± SEM are shown for two separate experiments with duplicates for each...con un subconjunto de GEFs, es demasiado alto para uso terapéutico, por lo que inhibidores más eficaces son necesarios. Por lo tanto, iniciamos la

  6. 17-DMAG Diminishes Hemorrhage-Induced Small Intestine Injury by Elevating Bcl-2 Protein and Inhibiting iNOS Pathway, TNF-alpha Increase, and Caspase-3 Activation

    Science.gov (United States)

    2011-06-03

    Hemorrhagic shock has been shown to cause systemic inflammation response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and multiple organ...vehicle) was administered at various doses to mice orally using feeding needles 16 h prior to hemorrhage. Histopathologic assessment. Jejunal...Bioluminescence Assay Kit HS II (Roche, Mannheim, Germany). Luminescence was measured with TD-20/20 luminometer 16 ( Turner Designs, Sunnyvale, CA, USA

  7. Pepeljajev eesti näitlejatega USA-s

    Index Scriptorium Estoniae

    2008-01-01

    Sasha Pepeljajevi tantsulavastust "Uksed" etendati USA rahvusvahelisel teatrifestivalil "Arts & Ideas". Vene-Eesti trupi Apparatus lavastus on pühendatud Daniil Harmsi 100. sünniaastapäevale ning põhineb tema töödel

  8. Pepeljajev eesti näitlejatega USA-s

    Index Scriptorium Estoniae

    2008-01-01

    Sasha Pepeljajevi tantsulavastust "Uksed" etendati USA rahvusvahelisel teatrifestivalil "Arts & Ideas". Vene-Eesti trupi Apparatus lavastus on pühendatud Daniil Harmsi 100. sünniaastapäevale ning põhineb tema töödel

  9. Dengue in Florida (USA

    Directory of Open Access Journals (Sweden)

    Jorge R. Rey

    2014-12-01

    Full Text Available Florida (USA, particularly the southern portion of the State, is in a precarious situation concerning arboviral diseases. The geographic location, climate, lifestyle, and the volume of travel and commerce are all conducive to arbovirus transmission. During the last decades, imported dengue cases have been regularly recorded in Florida, and the recent re-emergence of dengue as a major public health concern in the Americas has been accompanied by a steady increase in the number of imported cases. In 2009, there were 28 cases of locally transmitted dengue in Key West, and in 2010, 65 cases were reported. Local transmission was also reported in Martin County in 2013 (29 cases, and isolated locally transmitted cases were also reported from other counties in the last five years. Dengue control and prevention in the future will require close cooperation between mosquito control and public health agencies, citizens, community and government agencies, and medical professionals to reduce populations of the vectors and to condition citizens and visitors to take personal protection measures that minimize bites by infected mosquitoes.

  10. USA pelgab Hiina tehnoloogialuuret / Tõnis Arnover

    Index Scriptorium Estoniae

    Arnover, Tõnis, 1952-

    2005-01-01

    Hiina Ameerika-vastasest majandusluurest. USA luureameti andmetel on USA-s loodud üle kolme tuhande Hiina firma, kelle ülesandeks on tööstusliku või sõjalise tehnoloogia hankimine. Vt. samas: Hiina firmad ostavad üha suuremaid USA ettevõtteid

  11. Genetic variation in spatio-temporal confined USA300 community-associated MRSA isolates: a shift from clonal dispersion to genetic evolution?

    Directory of Open Access Journals (Sweden)

    Neeltje Carpaij

    Full Text Available INTRODUCTION: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA are increasingly isolated, with USA300-0114 being the predominant clone in the USA. Comparative whole genome sequencing of USA300 isolates collected in 2002, 2003 and 2005 showed a limited number of single nucleotide polymorphisms and regions of difference. This suggests that USA300 has undergone rapid clonal expansion without great genomic diversification. However, whole genome comparison of CA-MRSA has been limited to isolates belonging to USA300. The aim of this study was to compare the genetic repertoire of different CA-MRSA clones with that of HA-MRSA from the USA and Europe through comparative genomic hybridization (CGH to identify genetic clues that may explain the successful and rapid emergence of CA-MRSA. MATERIALS AND METHODS: Hierarchical clustering based on CGH of 48 MRSA isolates from the community and nosocomial infections from Europe and the USA revealed dispersed clustering of the 19 CA-MRSA isolates. This means that these 19 CA-MRSA isolates do not share a unique genetic make-up. Only the PVL genes were commonly present in all CA-MRSA isolates. However, 10 genes were variably present among 14 USA300 isolates. Most of these genes were present on mobile elements. CONCLUSION: The genetic variation present among the 14 USA300 isolates is remarkable considering the fact that the isolates were recovered within one month and originated from a confined geographic area, suggesting continuous evolution of this clone.

  12. FrogwatchUSA

    Science.gov (United States)

    Droege, S.

    2002-01-01

    full text: Frogs and toads are perhaps the most approachable and available of all our wildlife. In many, if not most places, they are abundant. In wetter parts of the East, almost anyone outside on a warm rainy night in spring will hear their dream-like calls, bellows, trills and snores. Even in the deserts of the Southwest, a nocturnal trip after a summer monsoon will yield toads moving across the roads toward a cacophonous orgy of mating and calling in the roadside ditches and desert pools. Birds share with frogs and toads this same sense of presence in our daily lives. But the difference is that birds are like the attractive neighbor who just never gives you the time of day, while frogs are more like the troglodyte who appears regularly to chat, philosophize, and have a beer. Uninvited, frogs appear in our water gardens, toads are on our stoops in the morning, we catch them when we are kids, raise their babies in the aquarium, and feel sorry when we find we have run them over with the lawnmower. When concerns about declining populations of amphibians reached the mass media, the Secretaries' office became involved. In addition to using traditional research mechanisms to investigate the problem, the Secretary also wanted to involve the public directly. The combination of high public appeal and the relative ease with which frog calls can be learned made a large-scale monitoring program for frogs and toads possible. What emerged was a program called Frogwatch USA, modeled after a successful Canadian program with a similar name. A web site was created (www.frogwatch.org) that presented potential frogwatchers with directions and a way to register their site online as well as enter their data. Observers chose where to count frogs depending on what they felt was important. For some it was their backyard, others chose vulnerable wetlands in their neighborhoods, or spots on local refuges and parks. Initially funded at $8,000 a year and then after two years increased to

  13. Fusion calculations for 40Ca+40Ca, 48Ca+48Ca, 40Ca+48Ca and p+208Pb systems

    Science.gov (United States)

    Gao, Jie; Zhang, Haifei; Bao, Xiaojun; Li, Junqing; Zhang, Hongfei

    2014-09-01

    The fusion cross sections of calcium isotopes and proton induced fusion have been calculated in terms of a coupled-channels formulation. Results indicated that there are big differences between the two fusion types. In the calculations of calcium isotopes fusion, the pair-transfer coupling has been applied in addition to the vibrational coupling, the combined effects showed that pair-transfer has played a significant role in the fusion process for the asymmetric 40Ca+48Ca system. The result of proton induced fusion for p+208Pb system successfully presents the fusion oscillation, which agrees with the experimental data rather well.

  14. Eesti piloodid õpivad USA-s Black Hawkiga lendama

    Index Scriptorium Estoniae

    2011-01-01

    Eesti õhujõudude helikopteripiloodid Rene Kallis ja Martin Noorsalu jäävad pärast väljaõpet kolmeks aastaks USA-sse teenima Marylandi üksuse juurde ning käivad selle aja jooksul ka missioonil Afganistanis

  15. 78 FR 39326 - Notice Pursuant To the National Cooperative Research and Production Act of 1993-Opendaylight...

    Science.gov (United States)

    2013-07-01

    ...., Gatineau, Quebec City, CANADA; Intel Corporation, Santa Clara, CA; Juniper Networks, Sunnyvale, CA; Microsoft Corporation, Redmond, WA; NEC Corporation, Tokyo, JAPAN; PLUMgrid Inc., Sunnyvale, CA; Radware LTD..., CA; Ciena Corporation, Hanover, MD; Cisco Systems Inc., San Jose, CA; Citrix Systems, Inc.,...

  16. USA presidendivalimistel eristus kolm kandidaati / Aadu Hiietamm

    Index Scriptorium Estoniae

    Hiietamm, Aadu, 1954-

    2008-01-01

    USA presidendivalimiste eelvalimistel jätkavad tihedat rebimist demokraatidest senaatorid Hillary Clinton ja Barack Obama, vabariiklastest tõusis esile senaator John McCain. Vt. samas: USA eelvalimiste kalender

  17. Eesti ja USA sõlmisid kokkuleppe

    Index Scriptorium Estoniae

    2017-01-01

    Kaitseminister Margus Tsahkna ja Ameerika Ühendriikide suursaadik Eestis James Melville allkirjastasid Eesti ja USA kaitsekoostöö kokkuleppe, mis hakkab reguleerima Eestis viibivate USA relvajõudude liikmete, nende pereliikmete ja lepinglaste õiguslikku staatust

  18. Eesti ja USA sõlmisid kokkuleppe

    Index Scriptorium Estoniae

    2017-01-01

    Kaitseminister Margus Tsahkna ja Ameerika Ühendriikide suursaadik Eestis James Melville allkirjastasid Eesti ja USA kaitsekoostöö kokkuleppe, mis hakkab reguleerima Eestis viibivate USA relvajõudude liikmete, nende pereliikmete ja lepinglaste õiguslikku staatust

  19. Megainvesteering USA terasekompaniilt / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2000-01-01

    USA kompanii RUMA toob tänavu Muuga sadamasse ülisuure, ligi 2,2 miljardi kroonise välisinvesteeringu teraseterminali näol. Tabel: Välisinvesteeringute TOP 10. Ilmunud ka: Delovõje Vedomosti 29. märts lk. 4

  20. USA panustab keskkonda / Jeffrey Goldstein

    Index Scriptorium Estoniae

    Goldstein, Jeffrey

    2007-01-01

    USA uus energiapoliitika kava näeb ette bensiini tarbimise vähendamist järgneva 10 aasta jooksul 20%, mis omakorda vähendab ameeriklaste autodest eralduva süsihappegaasi heitmete kasvu ning vähendab sõltuvust naftast

  1. Sõda, mille USA on juba kaotanud / Mart Helme

    Index Scriptorium Estoniae

    Helme, Mart, 1949-

    2003-01-01

    USA pole suutnud Iraagi-vastase sõja vajalikkust põhjendada, arvavad paljud USA poliitikavaatlejad. Rängaks diplomaatiliseks eksimuseks peetakse USA kaitseministri Donald Rumsfeldi avaldust, et USA ei vaja kellegi abi sõjas

  2. Sõda, mille USA on juba kaotanud / Mart Helme

    Index Scriptorium Estoniae

    Helme, Mart, 1949-

    2003-01-01

    USA pole suutnud Iraagi-vastase sõja vajalikkust põhjendada, arvavad paljud USA poliitikavaatlejad. Rängaks diplomaatiliseks eksimuseks peetakse USA kaitseministri Donald Rumsfeldi avaldust, et USA ei vaja kellegi abi sõjas

  3. 77 FR 6587 - Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA; Amended Certification...

    Science.gov (United States)

    2012-02-08

    ... Employment and Training Administration Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA..., applicable to workers of StarTek USA, Inc., Alexandria, Louisiana. The workers are engaged in the supply of..., Virginia location of StarTek USA, Inc. supplied call center services such as sales and technical...

  4. The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft.

    Science.gov (United States)

    Marcelo, Kathrina L; Means, Anthony R; York, Brian

    2016-10-01

    Calcium (Ca(2+)) is an essential ligand that binds its primary intracellular receptor calmodulin (CaM) to trigger a variety of downstream processes and pathways. Central to the actions of Ca(2+)/CaM is the activation of a highly conserved Ca(2+)/CaM kinase (CaMK) cascade that amplifies Ca(2+) signals through a series of subsequent phosphorylation events. Proper regulation of Ca(2+) flux is necessary for whole-body metabolism and disruption of Ca(2+) homeostasis has been linked to various metabolic diseases. Here we provide a synthesis of recent advances that highlight the roles of the Ca(2+)/CaMK axis in key metabolic tissues. An appreciation of this information is critical to understanding the mechanisms by which Ca(2+)/CaM-dependent signaling contributes to metabolic homeostasis and disease.

  5. USA andis Gruusiale vastakaid signaale / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2008-01-01

    USA välisministri Condoleezza Riceþi saabumisest Thbilisisse, et avaldada Gruusiale toetust. USA poolt antud soovitustest Gruusia president Mihhail Saakashvilile mitte jõudu kasutada ega alluda Venemaa provokatsioonidele ning hoiatustest sõjalise konflikti tagajärgede eest. USA analüütikute arvamusi

  6. USA andis Gruusiale vastakaid signaale / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2008-01-01

    USA välisministri Condoleezza Riceþi saabumisest Thbilisisse, et avaldada Gruusiale toetust. USA poolt antud soovitustest Gruusia president Mihhail Saakashvilile mitte jõudu kasutada ega alluda Venemaa provokatsioonidele ning hoiatustest sõjalise konflikti tagajärgede eest. USA analüütikute arvamusi

  7. Tartu tudengist USA suurpanga asepresidendiks / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2007-01-01

    Killu Tõugu Sanborn on Tartu ülikooli bioloogiateaduskonnast USA maineka ülikooli doktoriks ja sealt 58 miljardi dollari suuruse kapitaliga Comerica panga tippjuhiks jõudnuna eestlase läbilöögi musternäide. Haridustee USA-s ja elukutse valikud, müügiesindajast riskikapitalistiks

  8. USA tippametnik ootab puutumatuselepet / Liis Jemmer

    Index Scriptorium Estoniae

    Jemmer, Liis

    2003-01-01

    Videopressikonverentsil USA Tallinna saatkonnas ütles USA välisministri abi Lincoln P. Bloomfield, et tal on kahju, et EL avaldas Kesk- ja Ida-Euroopa riikidele survet mitte sõlmida USA kodanikele Rahvusvahelise Kriminaalkohtu suhtes puutumatust andvaid lepinguid

  9. USA kaitsetollide vastu / Joseph E. Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph E.

    2002-01-01

    USA poolt tollide kehtestamine imporditavale terasele on põhjustanud protesti. Riigid, eriti Euroopas, mis on võimelised USA-le vastu hakkama, peavad seda tegema nüüd. Karmide abinõude tarvitusele võtmine on nii nende kui ka USA huvides

  10. USA suursaadikuga Tallinna lahel / Katrin Kruss

    Index Scriptorium Estoniae

    Kruss, Katrin

    2007-01-01

    USA suursaadik Stanley Davis Phillips oma haridusteest, perekonnast, armastusest mere vastu, panusest isa Earl Phillipsi mööbliäri laiendamisse, golfiharrastusest, suursaadikute ettevalmistusest USA-s, suursaadiku residentsist Pirital ning uue saatkonnahoone otsingutest Tallinnas. Lisa: Stanley Davis Phillips

  11. USA suursaadikuga Tallinna lahel / Katrin Kruss

    Index Scriptorium Estoniae

    Kruss, Katrin

    2007-01-01

    USA suursaadik Stanley Davis Phillips oma haridusteest, perekonnast, armastusest mere vastu, panusest isa Earl Phillipsi mööbliäri laiendamisse, golfiharrastusest, suursaadikute ettevalmistusest USA-s, suursaadiku residentsist Pirital ning uue saatkonnahoone otsingutest Tallinnas. Lisa: Stanley Davis Phillips

  12. USA kaitsetollide vastu / Joseph E. Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph E.

    2002-01-01

    USA poolt tollide kehtestamine imporditavale terasele on põhjustanud protesti. Riigid, eriti Euroopas, mis on võimelised USA-le vastu hakkama, peavad seda tegema nüüd. Karmide abinõude tarvitusele võtmine on nii nende kui ka USA huvides

  13. Modelling middle pliocene warm climates of the USA

    Science.gov (United States)

    Haywood, A.M.; Valdes, P.J.; Sellwood, B.W.; Kaplan, J.O.; Dowsett, H.J.

    2001-01-01

    The middle Pliocene warm period represents a unique time slice in which to model and understand climatic processes operating under a warm climatic regime. Palaeoclimatic model simulations, focussed on the United States of America (USA), for the middle Pliocene (ca 3 Ma) were generated using the USGS PRISM2 2?? ?? 2?? data set of boundary conditions and the UK Meteorological Office's HadAMS General Circulation Model (GCM). Model results suggest that conditions in the USA during the middle Pliocene can be characterised as annually warmer (by 2?? to 4??C), less seasonal, wetter (by a maximum of 4 to 8 mm/day) and with an absence of freezing winters over the central and southern Great Plains. A sensitivity experiment suggests that the main forcing mechanisms for surface temperature changes in near coastal areas are the imposed Pliocene sea surface temperatures (SST's). In interior regions, reduced Northern Hemisphere terrestrial ice, combined with less snow cover and a reduction in the elevation of the western cordillera of North America, generate atmospheric circulation changes and positive albedo feedbacks that raise surface temperatures. A complex set of climatic feedback mechanisms cause an enhancement of the hydrological cycle magnifying the moisture bearing westerly wind belt during the winter season (Dec., Jan., Feb.). Predictions produced by the model are in broad agreement with available geological evidence. However, the GCM appears to underestimate precipitation levels in the interior and central regions of the southern USA. Copyright: Palaeontological Association, 22 June 2001.

  14. Demography and Intercontinental Spread of the USA300 Community-Acquired Methicillin-Resistant Staphylococcus aureus Lineage.

    Science.gov (United States)

    Glaser, Philippe; Martins-Simões, Patrícia; Villain, Adrien; Barbier, Maxime; Tristan, Anne; Bouchier, Christiane; Ma, Laurence; Bes, Michele; Laurent, Frederic; Guillemot, Didier; Wirth, Thierry; Vandenesch, François

    2016-02-16

    Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was recognized worldwide during the 1990s; in less than a decade, several genetically distinct CA-MRSA lineages carrying Panton-Valentine leukocidin genes have emerged on every continent. Most notably, in the United States, the sequence type 18-IV (ST8-IV) clone known as USA300 has become highly prevalent, outcompeting methicillin-susceptible S. aureus (MSSA) and other MRSA strains in both community and hospital settings. CA-MRSA bacteria are much less prevalent in Europe, where the European ST80-IV European CA-MRSA clone, USA300 CA-MRSA strains, and other lineages, such as ST22-IV, coexist. The question that arises is whether the USA300 CA-MRSA present in Europe (i) was imported once or on very few occasions, followed by a broad geographic spread, anticipating an increased prevalence in the future, or (ii) derived from multiple importations with limited spreading success. In the present study, we applied whole-genome sequencing to a collection of French USA300 CA-MRSA strains responsible for sporadic cases and micro-outbreaks over the past decade and United States ST8 MSSA and MRSA isolates. Genome-wide phylogenetic analysis demonstrated that the population structure of the French isolates is the product of multiple introductions dating back to the onset of the USA300 CA-MRSA clone in North America. Coalescent-based demography of the USA300 lineage shows that a strong expansion occurred during the 1990s concomitant with the acquisition of the arginine catabolic mobile element and antibiotic resistance, followed by a sharp decline initiated around 2008, reminiscent of the rise-and-fall pattern previously observed in the ST80 lineage. A future expansion of the USA300 lineage in Europe is therefore very unlikely. To trace the origin, evolution, and dissemination pattern of the USA300 CA-MRSA clone in France, we sequenced a collection of strains of this lineage from cases reported in France in

  15. 有关CA

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ 什么是CA? CA(Certificaton Authority)是认证机构的国际通称,是指对数字证书的申请者发放、管理、取消数字证书的机构.CA的作用是检查证书持有者身份的合法性,并签发证书(在证书上签字),以防证书被伪造或篡改.

  16. 76 FR 61740 - Geneon Entertainment (USA) Including On-Site Leased Workers From Interplace, Inc., Apple One and...

    Science.gov (United States)

    2011-10-05

    ... Interplace, Inc., Apple One and Robert Half Legal Santa Monica, CA; Amended Certification Regarding..., applicable to workers of Geneon Entertainment (USA), including on-site leased workers from Interplace, Inc., and Apple One, Santa Monica, California. The workers are engaged in activities related to...

  17. Eesti on USA uus lemmik / Argo Ideon

    Index Scriptorium Estoniae

    Ideon, Argo, 1966-

    2007-01-01

    President Toomas Hendrik Ilvese visiidist Washingtoni, kohtumistest USA presidendi George W. Bushi, asepresident Dick Cheney, asevälisminister John Negroponte, kaitseminister Robert M. Gates'i, USA Kongressi esindajatekoja spiikri Nancy Pelosi ja kongresmenidega. Eestil õnnestus korraldada USA pealinnas kohtumised, mille järjekorras ootab hulk palju suuremaid riike. Vabariigi President töövisiidil Ameerika Ühendriikides 25.-26.06.2007

  18. USA otsib Iraanist aktiivselt tuumainfot / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2005-01-01

    Iraan avaldas protesti USA luurelendude üle Iraani kohal. USA endine kaitseminister James Baker peab Iraani ja Põhja-Koreaga nende tuumaprogrammide hävitamiseks sõja alustamist suurimaks veaks. Kuigi Bushi meeskond rõhutab vajadust lahendada küsimus rahumeelselt, toovad Dick Cheney' ja Condoleezza Rice'i avaldused mitme USA kommentaatori arvates meelde Iraagi sõja eelse taktika

  19. 10 aastat USA-Balti hartat

    Index Scriptorium Estoniae

    2008-01-01

    10 aasta möödumisest 16. jaanuaril 1998 Valges Majas toimunud tseremooniast kui Ameerika Ühendriikide, Leedu, Läti ja Eesti presidendid allkirjastasid USA-Balti partnerlusharta. Eesti, Läti, Leedu presidentide ühisavaldusest - "ajalooline poliitiline teetähis Balti-USA riikide suhtes", tähistamaks USA-Balti partnerlusharta 10. aastapäeva. President George W. Bushi õnnitlusest Eesti, Läti ja Leedu elanikele harta 10. aastapäeva puhul\\

  20. Virginia Tech's Ashley White named to USA Today All-USA First Team

    OpenAIRE

    Crumbley, Liz

    2005-01-01

    Virginia Tech senior Ashley White, a University Honors student pursuing degrees in both materials science and engineering and music performance, has been named to USA Today's All-USA College Academic First Team.

  1. USA klaaskatuste murdmise aeg / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2008-01-01

    USA presidendivalimistel kandideeris esmakordselt afroameeriklane, presidendikandidaatide kampaanias osales naiskandidaat Hillary Clinton. Vt. samas: Obama isa kodukülas palvetati ja valmistuti suureks peoks

  2. BusinessUSA Resource Access API

    Data.gov (United States)

    General Services Administration — BusinessUSA connects businesses to government services and information. The API provides access to resource abstracts including programs, services, data, events, and...

  3. Topological organization of CA3-to-CA1 excitation.

    Science.gov (United States)

    Hongo, Yoshie; Ogawa, Koichi; Takahara, Yuji; Takasu, Keiko; Royer, Sebastien; Hasegawa, Minoru; Sakaguchi, Gaku; Ikegaya, Yuji

    2015-09-01

    The CA1-projecting axons of CA3 pyramidal cells, called Schaffer collaterals, constitute one of the major information flow routes in the hippocampal formation. Recent anatomical studies have revealed the non-random structural connectivity between CA3 and CA1, but little is known regarding the functional connectivity (i.e. how CA3 network activity is functionally transmitted downstream to the CA1 network). Using functional multi-neuron calcium imaging of rat hippocampal slices, we monitored the spatiotemporal patterns of spontaneous CA3 and CA1 burst activity under pharmacological GABAergic blockade. We found that spatially clustered CA3 activity patterns were transformed into layered CA1 activity sequences. Specifically, synchronized bursts initiated from multiple hot spots in CA3 ensembles, and CA1 neurons located deeper in the pyramidal cell layer were recruited during earlier phases of the burst events. The order of these sequential activations was maintained across the bursts, but the sequence velocity varied depending on the inter-burst intervals. Thus, CA3 axons innervate CA1 neurons in a highly topographical fashion.

  4. Biomarker CA125

    DEFF Research Database (Denmark)

    Kargo, Anette Stolberg

    be detected months before symptoms arise and recurrence is visible on imaging. Therefore, biochemical detection of potential relapse by CA125 assessment can cause significant distress. A decision aid (DA) is a tool that provides information and describes advantages and disadvantages of a specific intervention...

  5. Risk of Skin and Soft Tissue Infections among Children Found to be Staphylococcus aureus MRSA USA300 Carriers

    Science.gov (United States)

    Immergluck, Lilly Cheng; Jain, Shabnam; Ray, Susan M.; Mayberry, Robert; Satola, Sarah; Parker, Trisha Chan; Yuan, Keming; Mohammed, Anaam; Jerris, Robert C.

    2017-01-01

    Introduction The purpose of this study was to examine community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) carriage and infections and determine risk factors associated specifically with MRSA USA300. Methods We conducted a case control study in a pediatric emergency department. Nasal and axillary swabs were collected, and participants were interviewed for risk factors. The primary outcome was the proportion of S. aureus carriers among those presenting with and without a skin and soft tissue infection (SSTI). We further categorized S. aureus carriers into MRSA USA300 carriers or non-MRSA USA300 carriers. Results We found the MRSA USA300 carriage rate was higher in children less than two years of age, those with an SSTI, children with recent antibiotic use, and those with a family history of SSTI. MRSA USA300 carriers were also more likely to have lower income compared to non-MRSA USA300 carriers and no S. aureus carriers. Rates of Panton-Valentine leukocidin (PVL) genes were higher in MRSA carriage isolates with an SSTI, compared to MRSA carriage isolates of patients without an SSTI. There was an association between MRSA USA300 carriage and presence of PVL in those diagnosed with an abscess. Conclusion Children younger than two years were at highest risk for MRSA USA300 carriage. Lower income, recent antibiotic use, and previous or family history of SSTI were risk factors for MRSA USA300 carriage. There is a high association between MRSA USA300 nasal/axillary carriage and presence of PVL in those with abscesses. PMID:28210352

  6. Electrodeposition of Ca Metal in CaCl2-CaO Molten Salt

    Institute of Scientific and Technical Information of China (English)

    GUO; Jun-kang; WANG; Chang-shui; CAO; Long-hao; OUYANG; Ying-gen

    2013-01-01

    To realize the continuouscalciothermic reduction in molten salts,the electrodeposition behavior of Ca metal in CaCl2-CaO molten salt was investigated by cylic voltammetry.The cyclic voltammograms at the scan rate of 100 mV/s are shown in Fig.1.As is shown,the electrodeposition potential of Ca deviated from-1.66 V to-0.97 V after CaO was added to molten CaCl2 and the decomposition of CaO

  7. Computer Literate LD Students Shine at Lakewood Elementary School in Silicon Valley, CA.

    Science.gov (United States)

    Messinger, Mildred

    1983-01-01

    In Sunnyvale, California (the computer industry's "Silicon Valley") two teachers of elementary learning disabled (LD) students took a course in microcomputers, acquired three microcomputers with a grant, and trained the students to use computer-assisted instruction, with such results as that in one year, 37 LD students tutored 100 primary…

  8. Ekonomické vzťahy Kuby a USA

    OpenAIRE

    Lukaniaková, Nina

    2007-01-01

    Bakalárska práca sa zaoberá a objektívne hodnotí ekonomické vzťahy Spojených štátov a Kuby. Hlavným cieľom práce je preskúmať uvalenie embarga Spojenými štátmi na Kubu v roku 1962. Pre dôkladnejšie poznanie problematiky sú v práci uvedené historické udalosti, ktoré uvaleniu zákazu obchodovania predchádzali a následne, aký bol dopad tohoto kroku na obidva zúčastnené štáty. Práca hodnotí spomínané udalosti nielen z pohľadu USA ale aj z pohľadu Kuby. A v neposlednom rade práca poukazuje na súčas...

  9. Berliini müür USA-s varisemas / Mehis Replik

    Index Scriptorium Estoniae

    Replik, Mehis

    1998-01-01

    USA-s on pankade liitumine lõppjärgus. Tabelid: Pankade Euromoney TOP 200, suurima turuväärtusega pangad juunis 1998, Ida- ja Kesk-Euroopa pankade võrdlus koguvarade alusel. Euroopa ühinevad pangad. Artiklis on käsitletud ka USA pangandusalaseid õigusakte läbi ajaloo

  10. Krossil on probleeme USA viisaga? / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2011-01-01

    Eesti Päevaleht esitas USA Eesti-saatkonnale järelepärimise seoses sellega, et Eerik-Niiles Krossi USA-viisa on tühistatud. Saatkonna pressi- ja kultuuriatašee James Landi vastusest. Eerik-Niiles Krossi kommentaare

  11. Krossil on probleeme USA viisaga? / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2011-01-01

    Eesti Päevaleht esitas USA Eesti-saatkonnale järelepärimise seoses sellega, et Eerik-Niiles Krossi USA-viisa on tühistatud. Saatkonna pressi- ja kultuuriatašee James Landi vastusest. Eerik-Niiles Krossi kommentaare

  12. USA laenukriis peegeldub Põhjalas / Tõnis Arnover

    Index Scriptorium Estoniae

    Arnover, Tõnis, 1952-

    2007-01-01

    USA-s süvenev kinnisvaralaenukriis avaldab mõju ka tunduvalt riskantsematele Põhjamaade kinnisvaraturgudele. Siiski on Põhjalas kõrge riskiga hüpoteeklaenude osa võrreldes ülejäänud laenudega äärmiselt väike. Lisa: Kõige haavatavamad kinnisvaraturud; Mõjud mujal maailmas. Vt. samas: Põhjamaade börsid USAga samas taktis

  13. Bulgaaria valitsus tahab USA raketikilpi / Mihkel Niglas

    Index Scriptorium Estoniae

    Niglas, Mihkel

    2007-01-01

    Bulgaarias küsiti USA presidendilt George W. Bushilt, miks Poolasse ja Tšehhi kavandatav raketikilp ei hakka katma Bulgaariat. USA paigutab septembris Bulgaaria sõjabaasi üle 3000 sõduri. George W. Bush toetab Bulgaaria nõudmist Liibüale vabastada Bulgaaria meditsiiniõed

  14. USA's litterære superstjerne

    DEFF Research Database (Denmark)

    Bjerre, Thomas Ærvold

    2010-01-01

    Jonathan Franzen er den mest omtalte forfatter i USA lige nu og ombejlet af alle fra Time Magazine til Oprah Winfrey. Hvad er det, han kan, manden bag ”Freedom”?......Jonathan Franzen er den mest omtalte forfatter i USA lige nu og ombejlet af alle fra Time Magazine til Oprah Winfrey. Hvad er det, han kan, manden bag ”Freedom”?...

  15. USA tankid jõudsid Tapale

    Index Scriptorium Estoniae

    2017-01-01

    Tapale saabus poolsada USA sõjamasinat, nende seas neli tanki Abrams M1A2 ja 15 jalaväe lahingumasinat Bradley. Tehnikat hakkab kasutama USA maaväe 4. jalaväediviisi 68. soomusrügemendi esimese pataljoni C-kompanii

  16. Teadlased : USA liitub Kyoto protokolliga / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2004-01-01

    USA ja Austraalia on ainsad riigid, mis pole Kyoto protokollile alla kirjutanud. Princetoni ülikooli professori Michael Oppenheimeri arvates võib USA president George W. Bush oma seisukohti keskkonnaküsimustes muuta, sest teiseks ametiajaks valitud presidendid ei pea mõtlema uuele kampaaniale ning püüavad enne Valgest Majast lahkumist oma mainet maailma silmis parandada

  17. Poola ootab USA maaväelasi

    Index Scriptorium Estoniae

    2014-01-01

    Poola kaitseministri Tomasz Siemoniaki sõnul saadab USA Poolasse maavägesid, et laeindada NATO kohalolekut ajal, mil pingeline olukord Ukrainas kestab, kirjutas Washington Post. Siemoniak ütles lehele, et sõjalised planeerijad juba töötavad vastava kava üksikasjade kallal. Ta lisas, et tõenäoliselt saadetakse USA sõdureid ka Baltimaadesse

  18. Etteheide: USA okupeerib Haitit / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2010-01-01

    Prantsusmaa ja Brasiilia on esitanud protesti, sest USA sõjalennukitele on antud eelisõigus Haiti pealinna Port-au-Prince'i lennujaama kasutamisel. Paljude kommentaatorite hinnangul on Prantsusmaa püüdnud haarata prominentset rolli Haiti abistamisel, kuid USA on tegutsenud kiiremini ja jõulisemalt. Kaart

  19. USA relvastab Saddami toetajaid / Triin Oppi

    Index Scriptorium Estoniae

    Oppi, Triin

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 12. juuni 2007, lk. 6. USA koostööst Iraagis endiste vastaste ehk Saddam Husseini toetanud sunniitidega, sest valitsusväed ja USA sõdurid pole suutnud lüüa Iraagi mässulisi ja Al-Qaedat. Kaart: Koostööpiirkonnad

  20. Etteheide: USA okupeerib Haitit / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2010-01-01

    Prantsusmaa ja Brasiilia on esitanud protesti, sest USA sõjalennukitele on antud eelisõigus Haiti pealinna Port-au-Prince'i lennujaama kasutamisel. Paljude kommentaatorite hinnangul on Prantsusmaa püüdnud haarata prominentset rolli Haiti abistamisel, kuid USA on tegutsenud kiiremini ja jõulisemalt. Kaart

  1. Bulgaaria valitsus tahab USA raketikilpi / Mihkel Niglas

    Index Scriptorium Estoniae

    Niglas, Mihkel

    2007-01-01

    Bulgaarias küsiti USA presidendilt George W. Bushilt, miks Poolasse ja Tšehhi kavandatav raketikilp ei hakka katma Bulgaariat. USA paigutab septembris Bulgaaria sõjabaasi üle 3000 sõduri. George W. Bush toetab Bulgaaria nõudmist Liibüale vabastada Bulgaaria meditsiiniõed

  2. USA allveelaev uputas kalalaeva / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2001-01-01

    Hawaii lähistel õppustel kiiret pinnaletõusu harjutanud USA allveelaev USS Greeneville põrkas kokku Jaapani õppelaevaga Ehime Maru, õnnetuse tagajärjel hukkus tõenäoliselt 9 jaapanlast. Skeem: Õnnetused USA allveelaevadega

  3. USA raport hoiatab tuumaterroristide eest / Karin Volmer

    Index Scriptorium Estoniae

    Volmer, Karin

    2007-01-01

    USA-s tegutseva tuumaterrori vastase organisatsiooni Nuclear Threat Initiative (NTI) raport kinnitab maailma edusamme tuumamaterjali turvalisuses, kuid on ka palju ohuallikaid. Analüütikud kahtlevad Venemaa ja Pakistani armee usaldusväärsuses tuumamaterjali hoidmisel. Lisa: Tuumaterrori raport

  4. USA tankid jõudsid Tapale

    Index Scriptorium Estoniae

    2017-01-01

    Tapale saabus poolsada USA sõjamasinat, nende seas neli tanki Abrams M1A2 ja 15 jalaväe lahingumasinat Bradley. Tehnikat hakkab kasutama USA maaväe 4. jalaväediviisi 68. soomusrügemendi esimese pataljoni C-kompanii

  5. Sulfide capacities of CaO-CaF2-CaCl2 melts

    Science.gov (United States)

    Simeonov, Simeon; Sakai, Toshihiko; Maeda, Masafumi

    1992-06-01

    The sulfide capacityC_{s^{2 - } } = ({text{pct S}}^{{text{2 - }}} )(p_{{text{O}}_{text{2}} } /p_{{text{S}}_{text{2}} } )^{1/2} ) of CaO-CaF2-CaCl2 slag was determined at temperatures from 1000 °C to 1300 °C by equilibrating molten slag, molten silver, and CO-CO2-Ar gas mixture. The sulfide capacity increases with replacing CaCl2 by CaF2 in slags of constant CaO contents. The sulfide capacity also increases with increasing temperature as well as with increasing CaO content at a constant ratio of CaF2/CaCl2 of unity. A linear relationship between the sulfide capacity and carbonate capacity in literature was observed on a logarithmic scale.

  6. Ideaalne torm USA majanduses / Ken Goldstein ; interv. Neeme Raud

    Index Scriptorium Estoniae

    Goldstein, Ken

    2008-01-01

    USA majandusuuringute organisatsiooni The Conference Board analüütik USA majanduse olukorrast, mõjust maailmamajandusele, arenguvõimalustest ning uue presidendi vajalikest sammudest majanduses. Lisa: Enamuse arvates on USA valel teel

  7. USA National Phenology Network gridded products documentation

    Science.gov (United States)

    Crimmins, Theresa M.; Marsh, R. Lee; Switzer, Jeff R.; Crimmins, Michael A.; Gerst, Katharine L.; Rosemartin, Alyssa H.; Weltzin, Jake F.

    2017-02-23

    The goals of the USA National Phenology Network (USA-NPN, www.usanpn.org) are to advance science, inform decisions, and communicate and connect with the public regarding phenology and species’ responses to environmental variation and climate change. The USA-NPN seeks to facilitate informed ecosystem stewardship and management by providing phenological information freely and openly. One way the USA-NPN is endeavoring to accomplish these goals is by providing data and data products in a wide range of formats, including gridded real-time, short-term forecasted, and historical maps of phenological events, patterns and trends. This document describes the suite of gridded phenologically relevant data products produced and provided by the USA National Phenology Network, which can be accessed at www.usanpn.org/data/phenology_maps and also through web services at geoserver.usanpn.org/geoserver/wms?request=GetCapabilities.

  8. Correlation Between Sunspot Number and ca II K Emission Index

    CERN Document Server

    Bertello, Luca; Tlatov, Andrey; Singh, Jagdev

    2016-01-01

    Long-term synoptic observations in the resonance line of Ca II K constitute a fundamental database for a variety of retrospective analyses of the state of the solar magnetism. Synoptic Ca II K observations began in late 1904 at the Kodaikanal Observatory, in India. In early 1970s, the National Solar Observatory (NSO) at Sacramento Peak (USA) started a new program of daily Sun-as-a-star observations in the Ca II K line. Today the NSO is continuing these observations through its Synoptic Optical Long-term Investigations of the Sun (SOLIS) facility. These different data sets can be combined into a single disk-integrated Ca II K index time series that describes the average properties of the chromospheric emission over several solar cycles. We present such a Ca II K composite and discuss its correlation with the new entirely revised sunspot number data series. For this preliminary investigation, the scaling factor between pairs of time series was determined assuming a simple linear model for the relationship betwe...

  9. Correlation Between Sunspot Number and Ca ii K Emission Index

    Science.gov (United States)

    Bertello, Luca; Pevtsov, Alexei; Tlatov, Andrey; Singh, Jagdev

    2016-11-01

    Long-term synoptic observations in the resonance line of Ca ii K constitute a fundamental database for a variety of retrospective analyses of the state of the solar magnetism. Synoptic Ca ii K observations began in late 1904 at the Kodaikanal Observatory in India. In the early 1970s, the National Solar Observatory (NSO) at Sacramento Peak (USA) started a new program of daily Sun-as-a-star observations in the Ca ii K line. Today the NSO is continuing these observations through its Synoptic Optical Long-term Investigations of the Sun (SOLIS) facility. These different data sets can be combined into a single disk-integrated Ca ii K index time series that describes the average properties of the chromospheric emission over several solar cycles. We present such a Ca ii K composite and discuss its correlation with the new entirely revised sunspot number data series. For this preliminary investigation, the scaling factor between pairs of time series was determined assuming a simple linear model for the relationship between the monthly mean values during the duration of overlapping observations.

  10. Installation Restoration Program. Phase I: Records Search. Sunnyvale Air Force Station, California

    Science.gov (United States)

    1985-07-01

    bindweed (Convolvulus arvensis), 3-27 bristly ox tongue (Picris echioides), and sweet fennel ( Foeniculum vulgare ) (U.S. Army Corps of Engineers, 1981...glaucus), common barley (Hordeum vulgare ), and common foxtail (Hordeum hystrix). Introduced forbe common onsite are black mustard (Brassica nigra

  11. [Carbohydrate antigens CA 19-9, CA 242, CA 50 in liver diseases].

    Science.gov (United States)

    Nowak, J; Jakubowska, D; Wiczkowski, A; Sprzaczkowska, K; Stechły, T; Zmudziński, W; Grzesik, P; Walas, R; Jarzab, B

    1998-01-01

    Serum concentrations of CA 19-9, CA 242, and CA 50 were determined in patients with hepatitis and liver cirrhosis without cholestasis. The study included 63 patients with chronic persistent hepatitis (group A), chronic active hepatitis (group B), and liver cirrhosis (group C). The control group (K) consisted of 82 patients with: peptic ulcer, colorectal polypi or diverticulosis of the colon. CA 19-9 level normal in the majority of patients with liver diseases, however, it was found to be increased in 4 (23%) of patients with liver cirrhosis. There was no statistically significant difference in the frequency of increased level of CA 19-9 between liver diseases and the control group. The rate of elevated serum level of CA 242 in patients with liver diseases and in control group was similar respectively 12%; 8.5%). The elevated CA 50 levels were most frequently found in patients with liver pathology (50% in liver cirrhosis and chronic active hepatitis; 36% in chronic persistent hepatitis). The elevation of CA 50 serum level occurs very often in liver diseases, even when they are going without cholestasis. Thus, the antigen is not useful for differentiating between benign and cancer diseases of gastrointestinal tract. Antigen CA 50 is to be taken into account only after exclusion of the pathology of liver, especially cirrhosis. Other investigated antigens: CA 19-9 and CA 242 are influenced by liver diseases to a minor and neglectable extent. Antigen CA 19-9 is the marker of choice in gastrointestinal cancers.

  12. LHV soovib USA-s kohtuvälist kokkulepet / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2005-01-01

    Kohtuväline kokkulepe LHV ja USA väärtpaberituru järelevalveasutuse SEC vahel tähendaks külmutatud väärtpaberikontode avamist, ent tõenäoliselt ka seda, et LHV peab maksma trahvi. Kohtuistungil USA-s esindavad LHV töötajaid Kristjan Lepikut ja Oliver Peeki advokaadid. Lisa: Teisedki on "sundpuhkusel"

  13. Ilves kritiseeris USA juhtidega Venemaad / Dagne Hanschmidt

    Index Scriptorium Estoniae

    Hanschmidt, Dagne

    2008-01-01

    Ilmunud ka: Postimees : na russkom jazõke 21. apr. lk. 4. President Toomas Hendrik Ilves kohtus töövisiidil Ameerika Ühendriikidesse USA asepresidendi Dick Cheney ja riigisekretär Condoleezza Rice'iga. Arutusel olid Euroopa Liidu suhted Venemaaga, Venemaa käitumine Gruusiaga, NATO viimase tippkohtumise tulemused. USA välisminister C. Rice avaldas Eesti presidendile tänu Eesti silmapaistva panuse eest Afganistanis. Kohtumisi kommenteerivad Riigikogu Euroopa Liidu asjade komisjoni esimees Marko Mihkelson ja Riigikogu väliskomisjoni esimees Sven Mikser. Vt. samas: Euroliit andis USA viisavabadusele rohelise tee. Euroopa Liidu sise- ja justiitsministrite kohtumisel kiideti heaks otsused, mis võimaldavad Eestil liituda USA viisavabadusprogrammiga. Vabariigi President töövisiidil Ameerika Ühendriikides 17.-23.04.2008

  14. Ilves kritiseeris USA juhtidega Venemaad / Dagne Hanschmidt

    Index Scriptorium Estoniae

    Hanschmidt, Dagne

    2008-01-01

    Ilmunud ka: Postimees : na russkom jazõke 21. apr. lk. 4. President Toomas Hendrik Ilves kohtus töövisiidil Ameerika Ühendriikidesse USA asepresidendi Dick Cheney ja riigisekretär Condoleezza Rice'iga. Arutusel olid Euroopa Liidu suhted Venemaaga, Venemaa käitumine Gruusiaga, NATO viimase tippkohtumise tulemused. USA välisminister C. Rice avaldas Eesti presidendile tänu Eesti silmapaistva panuse eest Afganistanis. Kohtumisi kommenteerivad Riigikogu Euroopa Liidu asjade komisjoni esimees Marko Mihkelson ja Riigikogu väliskomisjoni esimees Sven Mikser. Vt. samas: Euroliit andis USA viisavabadusele rohelise tee. Euroopa Liidu sise- ja justiitsministrite kohtumisel kiideti heaks otsused, mis võimaldavad Eestil liituda USA viisavabadusprogrammiga. Vabariigi President töövisiidil Ameerika Ühendriikides 17.-23.04.2008

  15. Skandaal USAs : Obamat kujutati islamiterroristina / Aadu Hiietamm

    Index Scriptorium Estoniae

    Hiietamm, Aadu, 1954-

    2008-01-01

    The New Yorkeri esiküljel ilmus karikatuur, kus USA demokraatide presidendikandidaati Barack Obamat ja tema abikaasat Michelle'i kujutati islamiterroristidena, karikaturisti väitel joonistas ta selle Obama laimajate naeruvääristamiseks

  16. Endise USA vastuluuraja naasmine / Priit Pullerits

    Index Scriptorium Estoniae

    Pullerits, Priit, 1965-

    2008-01-01

    USA poliitikateaduste professorist Christopher L. Kukest, kes käesoleval õppeaastal töötab Fulbright Scholar programmi stipendiaadina Tartu Ülikoolis. Lisa: CV. Kommenteerib Tartu Ülikooli riigiteaduste instituudi doktorant Mihkel Solvak

  17. Gridded bathymetry of Kahoolawe Island, Hawaii, USA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Gridded bathymetry (10m) of Kahoolawe Island, Hawaii, USA. The data include multibeam bathymetry from the EM120, EM122, EM710, EM1020, and EM1002 multibeam sonar...

  18. USA tantsupress soovitab: Tiit Helimets! / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2007-01-01

    Eesti balletitantsijast Tiit Helimetsast, kes töötab alates 2005. aastast San Francisko balleti juhtsolistina. Lisatud nimekiri eesti tantsijatest välistruppides. USA tantsuajakirjas "Dance Magazine" ilmunud artiklist "25, keda vaadata"

  19. Endise USA vastuluuraja naasmine / Priit Pullerits

    Index Scriptorium Estoniae

    Pullerits, Priit, 1965-

    2008-01-01

    USA poliitikateaduste professorist Christopher L. Kukest, kes käesoleval õppeaastal töötab Fulbright Scholar programmi stipendiaadina Tartu Ülikoolis. Lisa: CV. Kommenteerib Tartu Ülikooli riigiteaduste instituudi doktorant Mihkel Solvak

  20. USA suursaadik : hirmud on alistanud lootuse / Toomas Sildam

    Index Scriptorium Estoniae

    Sildam, Toomas, 1961-

    2004-01-01

    Eestist lahkuv USA suursaadik Joseph de Thomas andis USA iseseisvuspäeva kõnes hinnangu Eesti toetusele Iraagis ja USA Iraagi-poliitikale. Parlamendiliige Eiki Berg USA suursaadiku kõnest. Vt. ka: Suursaadiku sõnum lk. 10

  1. USA tahab Iraagilt täispuutumatust / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2008-01-01

    USA ja Iraagi läbirääkimised USA vägede staatuse üle venivad, USA soovib oma sõduritele täielikku immuniteeti. Iraak olevat nõus nende USA üksuste immuniteediga, kes on sõjalistes rajatistes või missioonil, milles on varem kokku lepitud

  2. Quo vadis, USA dollar? : finantsturgude viimastest arengutest / Robert Liljequist

    Index Scriptorium Estoniae

    Liljequist, Robert

    2013-01-01

    Swedbank AB Soome strateegiajuht vastab küsimustele, mis puudutavad USA majandust alanud aastal, dollari n.-ö turvalise valuuta staatuse kaotamise ohtu, võlakirjade ostmise vähendamist ja selle mõju USA dollarile, Euroopa Keskpanga poliitika mõju euro ja USA dollari suhtele. Swebanki prognoos USA dollari kohta

  3. USA võtab hoogu maha / Tarvo Vaarmets

    Index Scriptorium Estoniae

    Vaarmets, Tarvo

    2010-01-01

    Pärast riiklike soodustuste lõppu koduostjatele on USA-s vähenenud kinnisvara soetamine, jaemüüjate käive langes juunis võrreldes maiga 0,5%. USA keskpanga presidendi Ben Bernanke hinnangul on USA majandus ebatavaliselt ebamäärane

  4. Lahingustress ajab USA sõdurid jooma / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 15. märts 2007, lk. 10. USA kaitseministeeriumi siseuurimuse kohaselt kasvas alkoholi kuritarvitamine tegevteenistuses olevate USA sõjaväelaste seas aastatel 2002-2005 enam kui 30%. Alkoholi ja uimastite tarvitamisest Iraagis ja Afganistanis teenivate USA sõdurite hulgas. Vt. samas: USA relvajõududes puhkes uus homoskandaal

  5. USA võtab hoogu maha / Tarvo Vaarmets

    Index Scriptorium Estoniae

    Vaarmets, Tarvo

    2010-01-01

    Pärast riiklike soodustuste lõppu koduostjatele on USA-s vähenenud kinnisvara soetamine, jaemüüjate käive langes juunis võrreldes maiga 0,5%. USA keskpanga presidendi Ben Bernanke hinnangul on USA majandus ebatavaliselt ebamäärane

  6. Quo vadis, USA dollar? : finantsturgude viimastest arengutest / Robert Liljequist

    Index Scriptorium Estoniae

    Liljequist, Robert

    2013-01-01

    Swedbank AB Soome strateegiajuht vastab küsimustele, mis puudutavad USA majandust alanud aastal, dollari n.-ö turvalise valuuta staatuse kaotamise ohtu, võlakirjade ostmise vähendamist ja selle mõju USA dollarile, Euroopa Keskpanga poliitika mõju euro ja USA dollari suhtele. Swebanki prognoos USA dollari kohta

  7. Lahingustress ajab USA sõdurid jooma / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 15. märts 2007, lk. 10. USA kaitseministeeriumi siseuurimuse kohaselt kasvas alkoholi kuritarvitamine tegevteenistuses olevate USA sõjaväelaste seas aastatel 2002-2005 enam kui 30%. Alkoholi ja uimastite tarvitamisest Iraagis ja Afganistanis teenivate USA sõdurite hulgas. Vt. samas: USA relvajõududes puhkes uus homoskandaal

  8. USA suursaadik : hirmud on alistanud lootuse / Toomas Sildam

    Index Scriptorium Estoniae

    Sildam, Toomas, 1961-

    2004-01-01

    Eestist lahkuv USA suursaadik Joseph de Thomas andis USA iseseisvuspäeva kõnes hinnangu Eesti toetusele Iraagis ja USA Iraagi-poliitikale. Parlamendiliige Eiki Berg USA suursaadiku kõnest. Vt. ka: Suursaadiku sõnum lk. 10

  9. USA tahab Iraagilt täispuutumatust / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2008-01-01

    USA ja Iraagi läbirääkimised USA vägede staatuse üle venivad, USA soovib oma sõduritele täielikku immuniteeti. Iraak olevat nõus nende USA üksuste immuniteediga, kes on sõjalistes rajatistes või missioonil, milles on varem kokku lepitud

  10. USA suhtub karmilt salainfo kasutamisse / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2005-01-01

    Juhtumitest USA-s, kus mitteavalikke pressiteateid on kasutatud ebaseadusliku tulu teenimiseks. Anonüümsust palunud Wall Streeti analüütiku sõnul võib LHV-ga seotud skandaal võtta halvema pöörde juhul, kui selgub, et äriuudisteagentuuris Business Wire'is oli keegi, kes tegi eestlastega koostööd

  11. Two new species of Pterostichus Bonelli subgenus Pseudoferonina Ball (Coleoptera, Carabidae, Pterostichini) from the mountains of central Idaho, U.S.A.

    OpenAIRE

    James Bergdahl; David Kavanaugh

    2011-01-01

    Two new species of Pterostichus Bonelli subgenus Pseudoferonina Ball, are described from the mountains of central Idaho: Pterostichus bousqueti Bergdahl [type locality = small tributaries of South Fork of Payette River watershed, ca. 1170 m (3840 ft), 44.0675°/-115.6822°, near Lowman, Salmon River Mountains, Boise County, Idaho, U.S.A.] and Pterostichus lolo Bergdahl [type locality = Cottonwood/Orogrande Creek, ca. 870 m (2850 ft), 46.5528°/-115.5522°, North Fork of Clearwater...

  12. Expression of Bacillus thuringiensis cytolytic toxin (Cyt2Ca1) in citrus roots to control Diaprepes abbreviatus larvae

    Science.gov (United States)

    Diaprepes abbreviatus (L.) is an important pest of citrus in the USA. Currently, no effective management strategies of Diaprepes abbreviatus exist in citriculture. To protect citrus against Diaprepes abbreviatus a transgenic citrus rootstock expressing Bacillus thuringiensis Cyt2Ca1, an insect toxin...

  13. Integrating and Amplifying Signal from Riboswitch Biosensors

    Science.gov (United States)

    2014-08-01

    MO): 34 mg/mL stock solution in 100% ethanol , final concentration 25 µg/mL of media for all procedures  LB Agar: 35 g/L Difco LB Agar (Becton...Costar 96-well assay plate 3631 ( Corning , NY)  Spectrophotometer (SpectroMax M5; Molecular Devices, Sunnyvale, CA) Prepare all media and buffer...Antituberculosis Compounds. Proc. Natl Acad. Sci. USA 105: 9994-9998 Xia, B., Bhatia, S., Bubenheim, B., Dadgar, M., Densmore, D., and Anderson, J. C. (2011

  14. Second International Conference on Accelerating Biopharmaceutical Development: March 9-12, 2009, Coronado, CA, USA.

    Science.gov (United States)

    Reichert, Janice M; Jacob, Nitya M; Amanullah, Ashraf

    2009-01-01

    The Second International Conference on Accelerating Biopharmaceutical Development was held in Coronado, California. The meeting was organized by the Society for Biological Engineering (SBE) and the American Institute of Chemical Engineers (AIChE); SBE is a technological community of the AIChE. Bob Adamson (Wyeth) and Chuck Goochee (Centocor) were co-chairs of the event, which had the theme "Delivering cost-effective, robust processes and methods quickly and efficiently." The first day focused on emerging disruptive technologies and cutting-edge analytical techniques. Day two featured presentations on accelerated cell culture process development, critical quality attributes, specifications and comparability, and high throughput protein formulation development. The final day was dedicated to discussion of technology options and new analysis methods provided by emerging disruptive technologies; functional interaction, integration and synergy in platform development; and rapid and economic purification process development.

  15. Collaborative Approaches to Flow Restoration in Intermittent Salmon-Bearing Streams: Salmon Creek, CA, USA

    Directory of Open Access Journals (Sweden)

    Cleo Woelfle-Erskine

    2017-03-01

    Full Text Available In Mediterranean-climate regions of California and southern Oregon, juvenile salmon depend on groundwater aquifers to sustain their tributary habitats through the dry summers. Along California’s North Coast streams, private property regimes on land have created commons tragedies in groundwater and salmon fisheries, both classic examples of commons that are often governed collectively and sustainably by their users. Understanding the linkages between salmon and groundwater is one major focus of salmon recovery and climate change adaptation planning in central California and increasingly throughout the Pacific Northwest. In this paper, I use extended field interviews and participant-observation in field ecology campaigns and regulatory forums to explore how, in one water-scarce, salmon-bearing watershed on California’s central coast, collaborators are synthesizing agency and landowner data on groundwater and salmon management. I focus on three projects undertaken by citizen scientists in collaboration with me and Gold Ridge Resource Conservation District staff: salmonid censuses, mapping of wet and dry stream reaches and well monitoring. I find that collaborative research initiated by local residents and agency personnel has, in some cases, created a new sense of ecological possibility in the region. I also consider some limitations of this collaborations, namely the lack of engagement with indigenous Pomo and Miwok tribal members, with the Confederated Tribes of Graton Rancheria and with farmworkers and other marginalized residents, and suggest strategies for deepening environmental justice commitments in future collaborative work.

  16. A population-based study examining the emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 in New York City

    Directory of Open Access Journals (Sweden)

    Panwar Monica

    2006-11-01

    Full Text Available Abstract Background Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA is a serious pathogen in several regions in the United States. It is unclear which populations are at high risk for the emergence of these strains. Methods All unique patient isolates of S. aureus were collected from hospitals in Brooklyn, NY over a three-month period. Isolates of MRSA that were susceptible to clindamycin underwent SCCmec typing. Isolates with the SCCmec type IV (characteristic of CA-MRSA strains underwent ribotyping. Demographic information involving the neighborhoods of Brooklyn was also gathered and correlated with the prevalence of CA-MRSA strains. Results Of 1316 isolates collected during the surveillance, 217 were MRSA susceptible to clindamycin. A total of 125 isolates possessed SCCmec type IV; 72 belonged to the USA300 strain and five belonged to the USA400 strain. Hospitals in the eastern part of the city had the highest prevalence of USA300 strain. Individuals in the eastern region, when compared to the western region, were more likely to be Black, Hispanic, female, and Conclusion The USA300 strain of CA-MRSA is emerging in New York City. In this population-based study, urban regions of lower socioeconomic status and with evidence of overcrowding appear to be at higher risk for the emergence of this pathogen.

  17. A multi-proxy palaeoecological and palaeoclimatic record within full glacial lacustrine deposits, western Tennessee, USA

    Science.gov (United States)

    Grimley, D.A.; Daniel, L.; Kaplan, S.W.; Yansa, C.H.; Curry, B. Brandon; Oches, E.A.

    2009-01-01

    The Fulton Section, along the Mississippi River in western Tennessee, USA, is a 1km continuous exposure (~20m vertically) of Quaternary fluvial and lacustrine deposits, inset within Eocene sediments and buried by thick loess. Fossiliferous slackwater lake sediments record maximum aggradation during the last two major glaciations, with deposition between ca. 190-140 ka and 24-1814C ka BP, based on amino acid and radiocarbon chronology, respectively. During the onset of full glacial conditions (ca. 24-22 14C ka BP), a relatively permanent shallow lake environment is indicated by ostracods, aquatic molluscs, and both pollen and macrofossils of aquatic plants. By 21.8 14C ka BP, increasing emergent plants, amphibious gastropods (Pomatiopsis) and heavier ??18O compositions suggest marsh-like conditions in a periodically drying lake. The surrounding uplands consisted of Picea-Pinus woodlands mixed with cool-temperate hardwoods (e.g. Quercus, Populus, Carya), grasses and herbs. More open conditions ensued ca. 20 14C ka BP, with loess and slopewash gradually infilling the former lake by 18 14C ka BP. Modern analogue analyses of ostracods and palaeontological evidence imply a full glacial climate similar to today's mixed-boreal zone in central Minnesota, USA, about 98C cooler in mean annual temperature than present-day western Tennessee. Copyright ?? 2009 John Wiley & Sons, Ltd.

  18. Long-term Synoptic Observations of Ca II K and Magnetic Flux

    Science.gov (United States)

    Bertello, L.; Pevtsov, A. A.; Tlatov, A. G.

    2016-04-01

    Long-term synoptic observations in the resonance line of Ca II K and measurements of the solar magnetic flux over several decades constitute a fundamental database for a variety of retrospective analyzes of the state of the solar magnetism. These data archives may also hold the key for untangling some of the mysteries behind the solar dynamo, which in turn could result in a better predictive capability of current dynamo models. Synoptic Ca II K observations began in 1907 at the Kodaikanal observatory (India) and in 1915 at the Mt Wilson (California, USA) solar observatory. By the early 1970s a number of synoptic programs for solar magnetic observations were established that provided full disk magnetograms. These programs include measurements carried out at the Mt Wilson 150-foot solar tower, Wilcox observatory (California, USA), and by the National Solar Observatory (NSO, USA). Today the NSO is continuing these observations through its Synoptic Optical Long-term Investigations of the Sun (SOLIS) facility. We will review some of these historical observations, their properties, and their importance for understanding the behavior of the solar magnetic field over multidecadal time scales. We will also show recent results about using Ca II K spectroheliograms and sunspot magnetic field measurements to reconstruct homogeneous series of pseudo-magnetograms prior the magnetograph era.

  19. "Riia ring, "luurepost ja tööjaotus USA esindustest Baltikumis 1920. aastatel / Eero Medijainen""

    Index Scriptorium Estoniae

    Medijainen, Eero, 1959-

    2012-01-01

    Diplomaatilisest taustast. USA esinduste rajamisest Baltikumi. Olukorrast USA saatkonnas 1922. aastal. USA sõjalisest vaatlejast "Balti provintsides" 1919-1922. Luurekeskusest ja Sergius Riisist. "Vene sektsiooni" formaliseeerumisest.

  20. "Riia ring, "luurepost ja tööjaotus USA esindustest Baltikumis 1920. aastatel / Eero Medijainen""

    Index Scriptorium Estoniae

    Medijainen, Eero, 1959-

    2012-01-01

    Diplomaatilisest taustast. USA esinduste rajamisest Baltikumi. Olukorrast USA saatkonnas 1922. aastal. USA sõjalisest vaatlejast "Balti provintsides" 1919-1922. Luurekeskusest ja Sergius Riisist. "Vene sektsiooni" formaliseeerumisest.

  1. A geochemical atlas of North Carolina, USA

    Science.gov (United States)

    Reid, J.C.

    1993-01-01

    A geochemical atlas of North Carolina, U.S.A., was prepared using National Uranium Resource Evaluation (NURE) stream-sediment data. Before termination of the NURE program, sampling of nearly the entire state (48,666 square miles of land area) was completed and geochemical analyses were obtained. The NURE data are applicable to mineral exploration, agriculture, waste disposal siting issues, health, and environmental studies. Applications in state government include resource surveys to assist mineral exploration by identifying geochemical anomalies and areas of mineralization. Agriculture seeks to identify areas with favorable (or unfavorable) conditions for plant growth, disease, and crop productivity. Trace elements such as cobalt, copper, chromium, iron, manganese, zinc, and molybdenum must be present within narrow ranges in soils for optimum growth and productivity. Trace elements as a contributing factor to disease are of concern to health professionals. Industry can use pH and conductivity data for water samples to site facilities which require specific water quality. The North Carolina NURE database consists of stream-sediment samples, groundwater samples, and stream-water analyses. The statewide database consists of 6,744 stream-sediment sites, 5,778 groundwater sample sites, and 295 stream-water sites. Neutron activation analyses were provided for U, Br, Cl, F, Mn, Na, Al, V, Dy in groundwater and stream water, and for U, Th, Hf, Ce, Fe, Mn, Na, Sc, Ti, V, Al, Dy, Eu, La, Sm, Yb, and Lu in stream sediments. Supplemental analyses by other techniques were reported on U (extractable), Ag, As, Ba, Be, Ca, Co, Cr, Cu, K, Li, Mg, Mo, Nb, Ni, P, Pb, Se, Sn, Sr, W, Y, and Zn for 4,619 stream-sediment samples. A small subset of 334 stream samples was analyzed for gold. The goal of the atlas was to make available the statewide NURE data with minimal interpretation to enable prospective users to modify and manipulate the data for their end use. The atlas provides only

  2. Iron-57 Moessbauer spectroscopy studies of meteorites recovered from Roosevelt County, USA

    Energy Technology Data Exchange (ETDEWEB)

    Berry, F.J. (Dept. of Chemistry, Open Univ., Milton Keynes (United Kingdom)); Bland, P.A. (Dept. of Earth Sciences, Open Univ., Milton Keynes (United Kingdom)); Oates, G. (Dept. of Chemistry, Open Univ., Milton Keynes (United Kingdom)); Pillinger, C.T. (Dept. of Earth Sciences, Open Univ., Milton Keynes (United Kingdom))

    1994-02-01

    Some H5 ordinary chondrite meteorites recovered from the desert region of Roosevelt County in New Mexico, USA and [sup 14]C dated to determine the terrestrial age have been examined by [sup 57]Fe Moessbauer spectroscopy. The preliminary results suggest the increasing oxidation of Fe[sup 0] in the iron-nickel alloy phase and of Fe[sup 2+] in the iron-sulphide and -silicate phases as a result of terrestrial weathering over ca. 38 000 years and which induces the formation of macroscopic iron oxide/oxyhydroxide phases. (orig.)

  3. Sonoma County, CA, 2013 Lidar

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Sonoma County Vegetation Mapping and LiDAR Consortium retained WSI to provide lidar and Orthophoto data and derived products in Sonoma County, CA. A classified LAS...

  4. CA125 in ovarian cancer

    DEFF Research Database (Denmark)

    Duffy, M J; Bonfrer, J M; Kulpa, J

    2005-01-01

    value in the detection of early ovarian cancer. At present, therefore, CA125, either alone or in combination with other modalities, cannot be recommended for screening for ovarian cancer in asymptomatic women outside the context of a randomized controlled trial. Preoperative levels in postmenopausal...... women, however, may aid the differentiation of benign and malignant pelvic masses. Serial levels during chemotherapy for ovarian cancer are useful for assessing response to treatment. Although serial monitoring following initial chemotherapy can lead to the early detection of recurrent disease......CA125 is currently the most widely used tumor marker for ovarian epithelial cancer. The aim of this article is to provide guidelines for the routine clinical use of CA125 in patients with ovarian cancer. Due to lack of sensitivity for stage I disease and lack of specificity, CA125 is of little...

  5. USA pensionisüsteem vajab kiiret reformimist / Raivo Sormunen

    Index Scriptorium Estoniae

    Sormunen, Raivo, 1976-

    2005-01-01

    Ameerika Ühendriikide pensionisüsteem vajab reformimist, kuna alates 2017. aastast tuleb USA pensionikindlustussüsteemil maksta pensionideks välja rohkem raha kui maksudena laekub. Tabel: USA sotsiaalkindlustussüsteem arvudes

  6. USA eksperdid näevad Baltimaid NATOs / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2001-01-01

    USA maineka välispoliitikaga tegeleva eraorganisatsiooni Välissuhete Nõukogu (Council of Foreign Relations CFR) analüütikute seisukohad USA välispoliitikast Balti riikide NATO-ga ühinemise kohta

  7. USA eksperdid näevad Baltimaid NATOs / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2001-01-01

    USA maineka välispoliitikaga tegeleva eraorganisatsiooni Välissuhete Nõukogu (Council of Foreign Relations CFR) analüütikute seisukohad USA välispoliitikast Balti riikide NATO-ga ühinemise kohta

  8. Bush soovib rahajagamisega USA majandust turgutada / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2008-01-01

    USA presidendi George W. Bushi plaanist maksta igale maksumaksjale tagasi 800 ja peredele 1600 dollarit, et majandust tõusule juhtida. USA Keskpanga poliitikast ja maailma börside jätkuvast langusest. Kommenteerivad: Romet Tepper, Jaanus Pikkani

  9. Bush soovib rahajagamisega USA majandust turgutada / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2008-01-01

    USA presidendi George W. Bushi plaanist maksta igale maksumaksjale tagasi 800 ja peredele 1600 dollarit, et majandust tõusule juhtida. USA Keskpanga poliitikast ja maailma börside jätkuvast langusest. Kommenteerivad: Romet Tepper, Jaanus Pikkani

  10. Cathodic behavior of molten CaCl2-CaO and CaCl2-NaCl-CaO

    Science.gov (United States)

    Wang, Shu-Lan; Wang, Wei; Li, Shi-Chao; Cao, Shan-Hui

    2010-12-01

    The cathodic behavior of molten CaCl2, CaCl2-CaO and equimolar CaCl2-NaCl-CaO was studied by cyclic voltammograms and constant potential polarization at temperatures of 1123 to 1173 K on molybdenum and titanium electrodes. The diffusion coefficient of Ca2+ (CaO) in molten CaCl2-CaO was calculated from the linear relationship between the square root of scan rate and the peak current density. The deposition potentials and the potential temperature coefficient of CaO in molten CaCl2-0.5mol%CaO and CaCl2-NaCl-0.5mol%CaO were also obtained from their cyclic voltammograms. The result shows that CaO is more easily reduced than CaCl2. The addition of NaCl in molten CaCl2-CaO induces the underpotential electrodeposition of CaO.

  11. Lahkuv USA saadik sai Maarjamaa Risti

    Index Scriptorium Estoniae

    2009-01-01

    USA suursaadik Stanley Davis Phillips tegi 8. jaanuaril 2009 Kadriorus lahkumisvisiidi president Toomas Hendrik Ilvesele. Suursaadiku teenete tunnustuseks andis president T. H. Ilves talle Maarjamaa Risti I klassi ordeni. Ilmunud ka: Eesti Elu 9. jaan. 2009, lk. 3, pealk.: President tänas Ameerika Ühendriikide suursaadikut

  12. USA: A Schema for Communicating Change.

    Science.gov (United States)

    Fabien, Miriam R.

    Professional communicators are often called upon to announce changes at places of business and to implement them in a timely fashion. One approach that works (and minimizes confusion) is to plan carefully to achieve three key objectives: Understanding, Support, and Action (USA). To promote understanding, those who have decided on the change should…

  13. USA survestab Mubarakit lahkuma / Hendrik Vosman

    Index Scriptorium Estoniae

    Vosman, Hendrik

    2011-01-01

    USA on teinud Egiptusele mitu ettepanekut, kõige tõenäolisemaks peetakse kava, mille kohaselt president Hosni Mubarak astuks tagasi kohe ja annaks võimu üle vahevalitsusele. Opositsioonijuhi ElBaradei ettepanekul peaks riiki hakkama juhtima presidendikogu

  14. The USA: Challenges of the Superpower

    Directory of Open Access Journals (Sweden)

    Dr. Ketevan Rostiashvili

    2012-01-01

    Full Text Available Since the collapse of the Soviet Union function and mission of the United States in the contemporary world system is one of the most debatable problems of academic litera-ture. This article is an attempt to analyze most recent socioeconomic and political tendencies of the USA for better understanding the scale of ongoing transformation of the society. As the level of integration of contemporary world is very high, transfor-mation of the USA provokes tectonic changes and transformation of the world system, its structure and nature. This study argues that, although the US primacy in the world is significantly challenged and shaken by external and internal factors, the USA still preserves its traditional function of economic, financial, military and political superpow-er, but in a quite different environment. The article predominantly uses materials drawn from the Central Intelligence Agency (CIA, The World Fact book 2012; U.S. Census Bureau, Statistical Abstract of the USA - 2012, the US Federal Budgets 2010-2012, and other valuable literature and sources.

  15. Euroopa ja USA: liidus tulevikuks / Barack Obama

    Index Scriptorium Estoniae

    Obama, Barack, 1961-

    2010-01-01

    Ameerika Ühendriikide president kirjutab 19.-20. novembril Lissabonis toimuvast NATO tippkohtumisest, USA ja Euroopa vastastikusest vajalikkusest ning NATO-sisesest koostööst. Barack Obama leiab, et NATO ja Venemaa võiksid taaskäivitada oma suhted

  16. Gridded bathymetry of Penguin Bank, Hawaii, USA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Gridded bathymetry (5 m cell size) of Penguin Bank, Hawaii, USA. The netCDF grid and ArcGIS ASCII file include multibeam bathymetry from the Simrad EM3002d, and...

  17. Fosfomycin Resistance in Escherichia coli, Pennsylvania, USA.

    Science.gov (United States)

    Alrowais, Hind; McElheny, Christi L; Spychala, Caressa N; Sastry, Sangeeta; Guo, Qinglan; Butt, Adeel A; Doi, Yohei

    2015-11-01

    Fosfomycin resistance in Escherichia coli is rare in the United States. An extended-spectrum β-lactamase-producing E. coli clinical strain identified in Pennsylvania, USA, showed high-level fosfomycin resistance caused by the fosA3 gene. The IncFII plasmid carrying this gene had a structure similar to those found in China, where fosfomycin resistance is commonly described.

  18. The USA PATRIOT Act: Archival Implications

    Science.gov (United States)

    Trinkaus-Randall, Gregor

    2005-01-01

    In October 2001, Congress passed the USA PATRIOT Act to strengthen the ability of the U.S. government to combat terrorism. Unfortunately, some sections of the Act strike at core values and practices of libraries and archives, especially in the areas of record keeping, privacy, confidentiality, security, and access to the collections. This article…

  19. Lahkuv USA saadik sai Maarjamaa Risti

    Index Scriptorium Estoniae

    2009-01-01

    USA suursaadik Stanley Davis Phillips tegi 8. jaanuaril 2009 Kadriorus lahkumisvisiidi president Toomas Hendrik Ilvesele. Suursaadiku teenete tunnustuseks andis president T. H. Ilves talle Maarjamaa Risti I klassi ordeni. Ilmunud ka: Eesti Elu 9. jaan. 2009, lk. 3, pealk.: President tänas Ameerika Ühendriikide suursaadikut

  20. USA juhitav Iraagi koalitsioon mureneb / Krister Paris

    Index Scriptorium Estoniae

    Paris, Krister

    2007-01-01

    Suurbritannia teatas vägede järkjärgulisest äratoomisest Iraagist. Oma sõdurite äratoomist plaanivad ka Taani ja taanlaste alluvuses tegutsev Leedu. Peale USA kavatseb vaid Austraalia vajaduse korral Iraaki sõdureid juurde saata. Kommenteerib Stanley Sloan. Lisa: Kohal ja lahkunud

  1. Toomas Hendrik Ilves kritiseeris USA juhtidega Venemaad

    Index Scriptorium Estoniae

    2008-01-01

    President Toomas Hendrik Ilves arutas kohtumistel USA asepresidendi Dick Cheney ja riigisekretär Condoleezza Rice'iga Euroopa Liidu ja Gruusia suhteid Venemaaga. Vabariigi President töövisiidil Ameerika Ühendriikides 17.-23.04.2008

  2. Võidurelvastumise tagasitulek : USA kiiluvees Venemaa ja Hiina / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2007-01-01

    USA eelarvekavas on ette nähtud kaitsekulutuste jätkuv suurenemine, suureneda võib ka relvajõudude isikkoosseis. Relvajõududele kulub USA-s ligi 4% SKT-st. Globaalselt liidetuna tõusid kõikide riikide kulutused relvajõududele 1990. aasta tasemele. Hiina ja Venemaa kaitsekulutustest. Lisad: Aasia riigid kasvatavad sõjalisi kulutusi; 25 riigil pole oma sõjaväge. Graafik: USA sõjalised kulutused

  3. USA suursaadik : toetame Eestit / Stanley Davis Phillips ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Phillips, Stanley Davis

    2007-01-01

    USA suursaadik Eestis Stanley Davis Phillips vastab küsimustele, mis puudutavad USA positsiooni Tõnismäe pronkssõduri suhtes, Eesti saatkonna piiramist Moskvas, USA ja Venemaa suhteid ning koostööd, sõda terrorismiga, USA kava paigutada Tšehhi ja Poolasse raketitõrjebaasid, Eesti presidendi Toomas Hendrik Ilvese visiiti USAsse. Lisa: Stanley Davis Phillips. Ilmunud ka: Postimees : na russkom jazõke 16. mai lk. 5

  4. Võidurelvastumise tagasitulek : USA kiiluvees Venemaa ja Hiina / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2007-01-01

    USA eelarvekavas on ette nähtud kaitsekulutuste jätkuv suurenemine, suureneda võib ka relvajõudude isikkoosseis. Relvajõududele kulub USA-s ligi 4% SKT-st. Globaalselt liidetuna tõusid kõikide riikide kulutused relvajõududele 1990. aasta tasemele. Hiina ja Venemaa kaitsekulutustest. Lisad: Aasia riigid kasvatavad sõjalisi kulutusi; 25 riigil pole oma sõjaväge. Graafik: USA sõjalised kulutused

  5. USA suursaadik : toetame Eestit / Stanley Davis Phillips ; interv. Erkki Bahovski

    Index Scriptorium Estoniae

    Phillips, Stanley Davis

    2007-01-01

    USA suursaadik Eestis Stanley Davis Phillips vastab küsimustele, mis puudutavad USA positsiooni Tõnismäe pronkssõduri suhtes, Eesti saatkonna piiramist Moskvas, USA ja Venemaa suhteid ning koostööd, sõda terrorismiga, USA kava paigutada Tšehhi ja Poolasse raketitõrjebaasid, Eesti presidendi Toomas Hendrik Ilvese visiiti USAsse. Lisa: Stanley Davis Phillips. Ilmunud ka: Postimees : na russkom jazõke 16. mai lk. 5

  6. Ilves kohtus esmaspäeval USA-s Barack Obamaga

    Index Scriptorium Estoniae

    2009-01-01

    President Toomas Hendrik Ilves kohtus 15. juunil 2009 Washingtonis USA presidendi Barack Obamaga ja vestles temaga nii majanduskriisist kui ka Eesti missioonist Afganistanis. Vabariigi President töövisiidil Ameerika Ühendriikides 9.-16.06.2009

  7. Tšehhid protestisid USA raketikilbi vastu / Igor Taro

    Index Scriptorium Estoniae

    Taro, Igor

    2007-01-01

    USA soovib rajada oma ballistiliste rakettide eest kaitsva süsteemi rajatisi Poola ja Tšehhi territooriumile, mille vastu on protestinud ka Venemaa. Tšehhi Trokaveci küla elanike korraldatud referendumist ja Prahas toimunud meeleavaldustest USA raketikilbi radarijaama vastu. Lisa: USA raketikilp

  8. USA tunnistab valge fosfori relvana kasutamist Iraagis / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2005-01-01

    Kui varem USA eitas valge fosfori kasutamist Iraagis Falluja linnas, siis nüüd on ta eitamisest loobunud. USA välisministeeriumi pressiteate kohaselt ei kasutatud fosforit keemiarelvana. Sütitavate relvade kasutamine tsiviilisikute vastu on keelatud. Vt. samas: Ahto Lobjakas. Europarlamendis USA hukkamõist

  9. Tšehhid protestisid USA raketikilbi vastu / Igor Taro

    Index Scriptorium Estoniae

    Taro, Igor

    2007-01-01

    USA soovib rajada oma ballistiliste rakettide eest kaitsva süsteemi rajatisi Poola ja Tšehhi territooriumile, mille vastu on protestinud ka Venemaa. Tšehhi Trokaveci küla elanike korraldatud referendumist ja Prahas toimunud meeleavaldustest USA raketikilbi radarijaama vastu. Lisa: USA raketikilp

  10. USA-reis nõuab biomeetrilist passi / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2004-01-01

    USA-s pikendati viisavabastusprogrammi biomeetrilise passi tähtaega 2005. aasta 26. oktoobrini. USA Eesti-saatkonna töötaja Christopher Smithi sõnul ei kehti viisavabadusprogrammi raames reisimise puhul passid, mida ei saa masinaga lugeda

  11. USA-reis nõuab biomeetrilist passi / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2004-01-01

    USA-s pikendati viisavabastusprogrammi biomeetrilise passi tähtaega 2005. aasta 26. oktoobrini. USA Eesti-saatkonna töötaja Christopher Smithi sõnul ei kehti viisavabadusprogrammi raames reisimise puhul passid, mida ei saa masinaga lugeda

  12. Corn Stover Nutrient Removal Estimates for Central Iowa, USA

    Directory of Open Access Journals (Sweden)

    Douglas L. Karlen

    2015-07-01

    Full Text Available One of the most frequent producer-asked questions to those persons striving to secure sustainable corn (Zea mays L. stover feedstock supplies for Iowa’s new bioenergy conversion or other bio-product facilities is “what quantity of nutrients will be removed if I harvest my stover?” Our objective is to summarize six years of field research from central Iowa, U.S.A. where more than 600, 1.5 m2 samples were collected by hand and divided into four plant fractions: vegetative material from the ear shank upward (top, vegetative material from approximately 10 cm above the soil surface to just below the ear (bottom, cobs, and grain. Another 400 stover samples, representing the vegetative material collected directly from a single-pass combine harvesting system or from stover bales were also collected and analyzed. All samples were dried, ground, and analyzed to determine C, N, P, K, Ca, Mg, S, Al, B, Cu, Fe, Mn, and Zn concentrations. Mean concentration and dry matter estimates for each sample were used to calculate nutrient removal and estimate fertilizer replacement costs which averaged $25.06, $20.04, $16.62, $19.40, and $27.41 Mg−1 for top, bottom, cob, stover, and grain fractions, respectively. We then used the plant fraction estimates to compare various stover harvest scenarios and provide an answer to the producer question posed above.

  13. 78 FR 38361 - Certain Portable Electronic Communications Devices, Including Mobile Phones and Components...

    Science.gov (United States)

    2013-06-26

    .... 1337, on behalf of Nokia Corporation of Finland and Nokia Inc., of Sunnyvale, California. A supplement... shall be served: (a) The complainants are: Nokia Corporation, Keilalahdentie 2-4, FIN-00045 Nokia Group, Espoo, Finland; Nokia Inc., 200 South Mathilda Avenue, Sunnyvale, CA 94086. (b) The respondents are...

  14. Coblation for tonsillectomy: an evidence-based review.

    Science.gov (United States)

    Shah, Udayan K; Dunham, Brian

    2007-01-01

    Coblation technology (Arthrocare Corp., Sunnyvale, Calif., USA) allows for tonsillectomy using plasma-mediated ablation. This review presents the evidence to date with respect to surgical and recovery measures, in order to promote an objective discussion of this surgical technology.

  15. The development of transcatheter aortic valve replacement in the USA.

    Science.gov (United States)

    Dvir, Danny; Barbash, Israel M; Ben-Dor, Itsik; Okubagzi, Petros; Satler, Lowell F; Waksman, Ron; Pichard, Augusto D

    2012-03-01

    The penetration rate of devices in general, and in transcatheter aortic valve replacement (TAVR) specifically, is significantly delayed in the United States of America (USA) compared with in Europe. This is mostly due to the mission statement of the regulatory agencies in the USA, which requires very rigorous clinical testing of a device prior to its approval. The USA had a major role in the development and evaluation of this technology and USA research has enabled clinicians inside and outside of the USA to conduct a concise scientifically based assessment of the performance of TAVR devices in terms of safety and efficacy. In the following review, we provide data on the development of TAVR in the USA, revealing the critical role the USA has played in this extraordinary process.

  16. Licensing the ACR-700 in the USA

    Energy Technology Data Exchange (ETDEWEB)

    Langman, V.; Ion, R. [Atomic Energy of Canada Limited, Mississauga, Ontario (Canada); Reid, C. [Bechtel Power Corporation, San Fransisco, California (United States); Snell, V. [Atomic Energy of Canada Limited, Mississauga, Ontario (Canada)

    2003-07-01

    Atomic Energy of Canada Ltd. (AECL), via its 100% owned US subsidiary AECL Technologies Inc., is performing a pre-application review of the Advanced CANDU Reactor (ACR) with the US Nuclear Regulatory Commission (USNRC). Completion of this pre-application review by mid-2004, is in support of an application to the USNRC for Standard Design Certification that is targeted for the fall of 2004. The intent of the pre-application review is to deal up-front with potential issues associated with the CANDU reactor genealogy of the ACR that are different from the Light Water Reactor (LWR) and Boiling Water Reactor (BWR) regulatory framework in the USA. The focus of the paper will be to describe the pre-application review process currently underway with the NRC staff. In the context of the pre-application review this paper will provide an overview of the licensing approach being used to introduce the ACR-700 to the USA. (author)

  17. Review of the USA National Phenology Network

    Science.gov (United States)

    Glynn, Pierre D.; Owen, Timothy W.

    2015-08-24

    In January 2014, leadership from the U.S. Geological Survey (USGS) Ecosystems Mission Area commissioned a review of the USA National Phenology Network (USA–NPN) Program. The Ecosystems Mission Area has a key stake in the USA–NPN, providing both supervision of its Director and most of the appropriated funds. The products and objectives of the program are relevant to six of the seven USGS Mission Areas as well as to at least four Department of the Interior (DOI) bureaus.

  18. Big Bend National Park, TX, USA, Mexico

    Science.gov (United States)

    1991-01-01

    The Sierra del Carmen of Mexico, across the Rio Grande River from Big Bend National Park, TX, (28.5N, 104.0W) is centered in this photo. The Rio Grande River bisects the scene; Mexico to the east, USA to the west. The thousand ft. Boquillas limestone cliff on the Mexican side of the river changes colors from white to pink to lavender at sunset. This severely eroded sedimentary landscape was once an ancient seabed later overlaid with volcanic activity.

  19. USA asepresident vihastas Venemaad / Erkki Bahovski

    Index Scriptorium Estoniae

    Bahovski, Erkki, 1970-

    2006-01-01

    Ilmunud ka: Postimees : na russkom jazõke 15. mai lk. 9. Läänemere ja Musta mere piirkonna riikide tippkohtumisel Vilniuses esinenud USA asepresident Dick Cheney märkis, et Ameerikal ja Euroopal on raske näha Venemaad demokraatlike riikide seas, kuna reformivastased püüavad Venemaal hävitada möödunud kümnendi edusamme. Vt. samas: Eesti pakub abiks oma kogemusi

  20. The site of net absorption of Ca from the intestinal tract of growing pigs and effect of phytic acid, Ca level and Ca source on Ca digestibility.

    Science.gov (United States)

    González-Vega, J Caroline; Walk, Carrie L; Liu, Yanhong; Stein, Hans H

    2014-01-01

    An experiment was conducted to test the hypothesis that the standardised digestibility of Ca in calcium carbonate and Lithothamnium calcareum Ca is not different regardless of the level of dietary Ca, and that phytic acid affects the digestibility of Ca in these two ingredients to the same degree. The objectives were to determine where in the intestinal tract Ca absorption takes place and if there are measurable quantities of basal endogenous Ca fluxes in the stomach, small intestine or large intestine. Diets contained calcium carbonate or L. calcareum Ca as the sole source of Ca, 0% or 1% phytic acid and 0.4% or 0.8% Ca. A Ca-free diet was also formulated and used to measure endogenous fluxes and losses of Ca. Nine growing pigs (initial body weight 23.8 ± 1.3 kg) were cannulated in the duodenum and in the distal ileum, and faecal, ileal and duodenal samples were collected. Duodenal endogenous fluxes of Ca were greater (p phytic acid, but decreased (p phytic acid, but may be affected by dietary Ca level depending on the Ca source. Calcium from calcium carbonate is mostly absorbed before the duodenum, but Ca from L. calcareum Ca is mostly absorbed in the jejunum and ileum.

  1. CA on CD评析

    Institute of Scientific and Technical Information of China (English)

    周秀会

    2007-01-01

    结合作者使用 CA On CD 的经验和体会,全面而具体地分析了 CA on CD 的使用功能,明确了其优点及不足之处,同时,针对这些不足之处进行了探索和尝试,提出了利用检索技巧解决这些不足之处的方法。并结合实例详细说明。

  2. The diagnostic value of joint detection of serum CA19-9, CA125 and CA242 for cholangiocarcinoma

    Institute of Scientific and Technical Information of China (English)

    Cui Da-Peng; Han Lei; Liu Zhen-Xian; Yang He; Zhang Ying-Chun

    2016-01-01

    Objective:To study the diagnostic value of joint detection of serum CA19-9, CA125 and CA242 for cholangiocarcinoma.Methods:A total of 35 patients with cholangiocarcinoma who received surgical resection in our hospital were selected as malignant group, 30 patients with cholelithiasis who received surgical resection in our hospital during the same period were selected as benign group, serum samples were collected before surgery to determine CA19-9, CA125 and CA242 content, and cholangiocarcinoma tissue and normal bile duct tissue were collected after surgery to determine the content of proliferation and invasion molecules. Results:Serum CA19-9, CA125 and CA242 levels of malignant group were significantly higher than those of control group; PROX-1, Ki-67, Bcl-2, Bad, Gab1, LOXL2, TRPM7 and CXCL12 levels in cholangiocarcinoma tissue were higher than those in benign bile duct tissue, and E-cadherin level was lower than that in benign bile duct tissue; serum CA19-9, CA125 and CA242 levels were positively correlated with PROX-1, Ki-67, Bcl-2, Bad, Gab1, LOXL2, TRPM7 and CXCL12 levels, and negatively correlated with E-cadherin level.Conclusion:Joint detection of serum CA19-9, CA125 and CA242 can not only provide reference for the diagnosis of cholangiocarcinoma, but can also provide basis for the evaluation of proliferation, invasion and other malignant biological behaviors.

  3. Asia prostate cancer study (A-CaP Study launch symposium

    Directory of Open Access Journals (Sweden)

    Hideyuki Akaza

    2016-09-01

    Full Text Available The Asian Prostate Cancer (A-CaP Study is an Asia-wide initiative that has been developed over the course of 2 years. The A-CaP Study is scheduled to begin in 2016, when each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognosis investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea. The inaugural Board Meeting of A-CaP was held on December 11, 2015 at the Research Center for Advanced Science and Technology, The University of Tokyo, attended by representatives of all participating countries and regions, who signed a memorandum of understanding concerning registration for A-CaP. Following the Board Meeting an A-CaP Launch Symposium was held. The symposium was attended by representatives of countries and regions participating in A-CaP, who gave presentations. Presentations and a keynote address were also delivered by representatives of the University of California San Francisco, USA, and the Peter MacCallum Cancer Centre, Australia, who provided insight and experience on similar databases compiled in their respective countries.

  4. Complete nucleotide sequence and genome organization of an endornavirus from bottle gourd (Lagenaria siceraria) in California, U.S.A.

    Science.gov (United States)

    Kwon, Sun-Jung; Tan, Shih-Hua; Vidalakis, Georgios

    2014-08-01

    The full-length nucleotide sequence and genome organization of an Endornavirus isolated from ornamental hard shell bottle gourd plants (Lagenaria siceraria (Molina) Standl.) in California (CA), USA tentatively named L. siceraria endornavirus-California (LsEV-CA) was determined. The LsEV-CA genome was 15088 bp in length, with a G + C content of 36.55 %. The lengths of the 5' and 3' untranslated regions were 111 and 52 bp, respectively. The genome of LsEV-CA contained one large ORF encoding a 576 kDa polyprotein. The predicted protein contains two glycosyltransferase motifs, as well as RNA-dependent RNA polymerase and helicase domains. LsEV-CA was detected in healthy-looking field-grown gourd plants, as well as plants expressing yellows symptoms. It was also detected in non-symptomatic greenhouse-grown gourd seedlings grown from seed obtained from the same field sites. These preliminary data indicate that LsEV-CA is likely not associated with the gourd-yellows syndrome observed in the field.

  5. Isotopic Effects on Stereodynamics for Ca+HCI, Ca+DCI, and Ca+TClReactions

    Institute of Scientific and Technical Information of China (English)

    Li-zhi Wang; Chuan-lu Yang; Jing-juan Liang; Jing Xiao; Qing-gang Zhang

    2011-01-01

    The vector correlations in Ca+HC1,Ca+DCI,and Ca+TCI reactions have been investigated by means of the quasi-classical trajectory calculations on PES constructed by means of multireference configuration interaction.The distributions of P(θr),P(Φr) and the PDDCSs of (2π/σ)(dσ00/dωt),(2π/σ)(dσ20/dωt),(2π/σ)(dσ22+/dωt),(2π/σ)(dσ21-/dωt) have been calculated based on the surface.The remarkable isotopic effects in the reactions are observed,and the mechanism which may be ascribed to different mass factors is discussed.

  6. Paediatric tonsillectomy: radiofrequency-based plasma dissection compared to cold dissection with sutures

    Science.gov (United States)

    Di Rienzo Businco, L; Coen Tirelli, G

    2008-01-01

    Summary Aim of this study was to compare post-operative recovery over 14 days in children submitted to tonsillectomy using a bipolar radiofrequency-based plasma device (Coblation®, Evac 70, ArthroCare Corp, Sunnyvale, CA, USA) to cold dissection. Paediatric patients (n = 42) aged 5-16 years old with chronic tonsillitis underwent tonsillectomy using cold dissection with suture ligatures or a plasma device (Evac 70, ArthroCare Corp, Sunnyvale, CA, USA). Pain intensity on the first day, use of analgesics, type of diet, and days of pain, fever, nausea, and absence from school were determined. Groups were compared using time-to-event (Kaplan-Meier) curves and statistically evaluated using the Breslow (generalized Wilcoxon) test. Children undergoing plasma tonsillectomy reported significantly less pain on the first post-operative day (1.2 ± 0.9 vs. 3.5 ± 1.5, p tonsillectomy was adopted for the majority of cases. Benefits of the plasma device include the possibility both to excise tissue and coagulate bleeding vessels using the same device whilst improving quality of post-operative recovery over cold dissection with suture ligatures. PMID:18669070

  7. EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.

    Science.gov (United States)

    Vais, Horia; Mallilankaraman, Karthik; Mak, Don-On Daniel; Hoff, Henry; Payne, Riley; Tanis, Jessica E; Foskett, J Kevin

    2016-01-26

    The mitochondrial uniporter (MCU) is an ion channel that mediates Ca(2+) uptake into the matrix to regulate metabolism, cell death, and cytoplasmic Ca(2+) signaling. Matrix Ca(2+) concentration is similar to that in cytoplasm, despite an enormous driving force for entry, but the mechanisms that prevent mitochondrial Ca(2+) overload are unclear. Here, we show that MCU channel activity is governed by matrix Ca(2+) concentration through EMRE. Deletion or charge neutralization of its matrix-localized acidic C terminus abolishes matrix Ca(2+) inhibition of MCU Ca(2+) currents, resulting in MCU channel activation, enhanced mitochondrial Ca(2+) uptake, and constitutively elevated matrix Ca(2+) concentration. EMRE-dependent regulation of MCU channel activity requires intermembrane space-localized MICU1, MICU2, and cytoplasmic Ca(2+). Thus, mitochondria are protected from Ca(2+) depletion and Ca(2+) overload by a unique molecular complex that involves Ca(2+) sensors on both sides of the inner mitochondrial membrane, coupled through EMRE.

  8. KWU-werkersklasdramas in Afrikaans (ca. 1930 - ca. 1950

    Directory of Open Access Journals (Sweden)

    J. L. Coetser

    1999-05-01

    Full Text Available GWU working class theatre in Afrikaans (ca. 1930 - ca. 1950In 1984 Elsabé Brink drew attention to plays, prose and poetry written between 1930 and 1950 in Afrikaans by members of the Garment Workers’ Union (GWU. Scholars such as Stander and Willemse (1992, Van Niekerk (1996 and Van Wyk (1995, 1997 have also referred to GWU plays. Apart from these overviews, GWU plays as such have not yet received the attention they deserve. This article presents a revaluation, initially by providing an overview of their contents, followed by an examination of cultural, economic and political influences. It is argued that - retrospectively - the GWU plays reflected a unique cultural specificity from the framework established by Sitas (1986 for more contemporary working class theatre.

  9. Ca2+ dynamics in zebrafish morphogenesis

    Directory of Open Access Journals (Sweden)

    Yusuke Tsuruwaka

    2017-01-01

    Full Text Available Intracellular calcium ion (Ca2+ signaling is heavily involved in development, as illustrated by the use of a number of Ca2+ indicators. However, continuous Ca2+ patterns during morphogenesis have not yet been studied using fluorescence resonance energy transfer to track the Ca2+ sensor. In the present study, we monitored Ca2+ levels during zebrafish morphogenesis and differentiation with yellow cameleon, YC2.12. Our results show not only clear changes in Ca2+ levels but also continuous Ca2+ patterns at 24 hpf and later periods for the first time. Serial Ca2+dynamics during early pharyngula period (Prim-5-20; 24–33 hpf was successfully observed with cameleon, which have not reported anywhere yet. In fact, high Ca2+ level occurred concurrently with hindbrain development in segmentation and pharyngula periods. Ca2+ patterns in the late gastrula through segmentation periods which were obtained with cameleon, were similar to those obtained previously with other Ca2+sensor. Our results suggested that the use of various Ca2+ sensors may lead to novel findings in studies of Ca2+ dynamics. We hope that these results will prove valuable for further research in Ca2+ signaling.

  10. Ca2+-permeable and Ca2+-impermeable AMPA receptors coexist on horizontal cells.

    Science.gov (United States)

    Huang, Shi-Yong; Liang, Pei-Ji

    2005-02-28

    Fura-2 fluorescent calcium imaging was used for analyzing the subtype of AMPA receptors in freshly dissociated horizontal cells of carp retina. Exogenous application of AMPA induced an increase of intracellular concentration of free Ca2+ ([Ca2+]i) in horizontal cells, while the [Ca2+]i increase was partly inhibited by nifedipine. The residual [Ca2+]i increase was completely eliminated by joro spider toxin-3, a blocker of Ca2+-permeable AMPA receptors. On the other hand, the application of pentobarbital, which blocked Ca2+-impermeable AMPA receptors, could also partly inhibit the increase of [Ca2+]i, implying that the application of AMPA induced the activation of both Ca2+-permeable and Ca2+-impermeable AMPA receptors and the consequent activation of voltage-gated Ca2+ channels. Taken together, these results suggested that Ca2+-permeable and Ca2+-impermeable AMPA receptors were coexpressed on horizontal cells.

  11. Water Content in the SW USA Mantle Lithosphere: FTIR Analysis of Dish Hill and Kilbourne Hole Pyroxenites

    Science.gov (United States)

    Gibler, Robert; Peslier, Anne H.; Schaffer, Lillian Aurora; Brandon, Alan D.

    2014-01-01

    Kilbourne Hole (NM, USA) and Dish Hill (CA, USA) mantle xenoliths sample continental mantle in two different tectonic settings. Kilbourne Hole (KH) is located in the Rio Grande rift. Dish Hill (DH) is located in the southern Mojave province, an area potentially affected by subduction of the Farallon plate beneath North America. FTIR analyses were obtained on well characterized pyroxenite, dunite and wehrlite xenoliths, thought to represent crystallized melts at mantle depths. PUM normalized REE patterns of the KH bulk-rocks are slightly LREE enriched and consistent with those of liquids generated by 6% melting of a spinel peridotite source. Pyroxenite pyroxenes have no detectable water but one DH wehrlite, which bulk-rock is LREE enriched, has 4 ppm H2O in orthopyroxene and 2 Ga. The Farallon subduction appears to have enriched in water the southwestern United States lithospheric mantle further east than DH, beneath the Colorado plateau.

  12. USA relvastab araabia maid miljardite dollaritega / Kunnar Kukk

    Index Scriptorium Estoniae

    Kukk, Kunnar

    2007-01-01

    USA välisminister Condoleezza Rice ja kaitseminister Robert Gates tegid visiidi Saudi-Araabiasse. Arvatakse, et nad on pehmendamas katastroofi, mis järgneks USA vägede järk-järgulisele taandumisele Iraagist. USA kavatseb anda Pärsia riikidele sõjalist abi, et tuua Iraan kolmepoolsetele läbirääkimistele. Lisa: Kodusõda võib olla vältimatu

  13. INTERNATIONAL STRATEGIES OF BUSINESS INCUBATION: THE USA, GERMANY AND RUSSIA

    National Research Council Canada - National Science Library

    Evgeny Tsaplin; Yulia Pozdeeva

    2017-01-01

    ...: the USA, Germany, and Russia using both a comparative theoretical analysis of different performance criteria of business incubators and interviewing experts who work directly with startup companies...

  14. Kriisis USA valis, Euroopa rõõmustas / Liisi Poll

    Index Scriptorium Estoniae

    Poll, Liisi, 1980-

    2008-01-01

    Maailma reaktsioonidest Barack Obama valimisel USA uueks presidendiks. Vt. samas: Osariikide referendumid; Obama otsib kaastöötajaid; Katkeid maailma riigijuhtide õnnitlustest Barack Obama presidendiks valimise puhul

  15. USA erisaadik : USA investorid Eestis rahul / J. Frank Mermoud ; interv. Sirje Rank

    Index Scriptorium Estoniae

    Mermoud, J. Frank

    2004-01-01

    Ameerika Ühendriikide välisministri nõunik ja erisaadik majandusküsimustes kiidab Eesti edu, räägib USA investorite rahuolust Eesti majanduskeskkonnaga ja väljendab muret Euroopa Liidu kavade pärast maksude ühtlustamiseks

  16. Lattice Dynamics of fcc Ca

    DEFF Research Database (Denmark)

    Stassis, C.; Zaretsky, J.; Misemer, D. K.;;

    1983-01-01

    to the propagation of elastic waves. The frequencies of the T1[ξξ0] branch for ξ between approximately 0.5 and 0.8 are slightly above the velocity-of-sound line determined from the low-frequency measurements. Since a similar effect has been observed in FCC Yb, it is natural to assume that the anomalous dispersion......A large single crystal of FCC Ca was grown and was used to study the lattice dynamics of this divalent metal by coherent inelastic neutron scattering. The phonon dispersion curves were measured, at room temperature, along the [ξ00], [ξξ0], [ξξξ], and [0ξ1] symmetry directions. The dispersion curves...... bear a striking resemblance to those of FCC Yb, which is also a divalent metal with an electronic band structure similar to that of Ca. In particular, the shear moduli c44 and (c11-c 12)/2 differ by a factor of 3.4, which implies that FCC Ca (like FCC Yb) is very anisotropic with regard...

  17. Continuously Tunable Ca2+ Regulation of RNA-Edited CaV1.3 Channels

    Directory of Open Access Journals (Sweden)

    Hojjat Bazzazi

    2013-10-01

    Full Text Available CaV1.3 ion channels are dominant Ca2+ portals into pacemaking neurons, residing at the epicenter of brain rhythmicity and neurodegeneration. Negative Ca2+ feedback regulation of CaV1.3 channels (CDI is therefore critical for Ca2+ homeostasis. Intriguingly, nearly half the CaV1.3 transcripts in the brain are RNA edited to reduce CDI and influence oscillatory activity. It is then mechanistically remarkable that this editing occurs precisely within an IQ domain, whose interaction with Ca2+-bound calmodulin (Ca2+/CaM is believed to induce CDI. Here, we sought the mechanism underlying the altered CDI of edited channels. Unexpectedly, editing failed to attenuate Ca2+/CaM binding. Instead, editing weakened the prebinding of Ca2+-free CaM (apoCaM to channels, which proves essential for CDI. Thus, editing might render CDI continuously tunable by fluctuations in ambient CaM, a prominent effect we substantiate in substantia nigral neurons. This adjustability of Ca2+ regulation by CaM now looms as a key element of CNS Ca2+ homeostasis.

  18. An uncommon presentation for a severe invasive infection due to methicillin-resistant Staphylococcus aureus clone USA300 in Italy: a case report

    Directory of Open Access Journals (Sweden)

    Tronci Mirella

    2008-04-01

    Full Text Available Abstract Background Methicillin resistant Staphylococcus aureus (MRSA has been considered for many years a typical nosocomial pathogen. Recently MRSA has emerged as a frequent cause of infections in the community. More commonly, community-acquired (CA-MRSA is a cause of infections of the skin and soft-tissues, but life-threatening infections such as necrotizing pneumonia and sepsis can occasionally occur. Case presentation This report describes an uncommon presentation of invasive CA-MRSA infection in an adolescent without known risk factors. The presentation was typical for bacterial meningitis, but the clinical findings also revealed necrotizing pneumonia. Following the development of deep venous thrombosis, the presence of an inherited trombophilic defect (factor V Leiden was detected. The patient was successfully treated with an antibiotic combination including linezolid and with anticoagulant therapy. CA-MRSA was isolated from both cerebrospinal fluid and blood. The isolates were resistant to oxacillin and other beta-lactam antibiotics and susceptible to the other antibiotics tested including erythromycin. Molecular typing revealed that the strains contained the Panton-Valentine leukocidin genes and type IV SCCmec, and were ST8, spa type t008, and agr type 1. This genetic background is identical to that of the USA300 clone. Conclusion This report highlights that meningitis can be a new serious presentation of CA-MRSA infection. CA-MRSA strains with the genetic background of the USA300 clone are circulating in Italy and are able to cause severe infections.

  19. Läbikatsumine USA lennujaamades riivab siin tehtavast vähem / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2010-01-01

    USA sisejulgeoleku ministeeriumi privaatsuse ja andmekaitse juht Mary Ellen Callahan kinnitab, et USA-sse reisivate inimeste krediitkaardiandmeid kasutatakse vaid elektroonilise reisi autoriseerimise süsteemi jaoks ning andmeid säilitab USA rahandusministeerium. Ta on arvamusel, et USA-s on kehaskannerite kasutamisel reisija privaatsuse kaitse parem kui Euroopas

  20. Läbikatsumine USA lennujaamades riivab siin tehtavast vähem / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2010-01-01

    USA sisejulgeoleku ministeeriumi privaatsuse ja andmekaitse juht Mary Ellen Callahan kinnitab, et USA-sse reisivate inimeste krediitkaardiandmeid kasutatakse vaid elektroonilise reisi autoriseerimise süsteemi jaoks ning andmeid säilitab USA rahandusministeerium. Ta on arvamusel, et USA-s on kehaskannerite kasutamisel reisija privaatsuse kaitse parem kui Euroopas

  1. Fine tuning of cytosolic Ca 2+ oscillations

    Science.gov (United States)

    Dupont, Geneviève; Combettes, Laurent

    2016-01-01

    Ca 2+ oscillations, a widespread mode of cell signaling, were reported in non-excitable cells for the first time more than 25 years ago. Their fundamental mechanism, based on the periodic Ca 2+ exchange between the endoplasmic reticulum and the cytoplasm, has been well characterized. However, how the kinetics of cytosolic Ca 2+ changes are related to the extent of a physiological response remains poorly understood. Here, we review data suggesting that the downstream targets of Ca 2+ are controlled not only by the frequency of Ca 2+ oscillations but also by the detailed characteristics of the oscillations, such as their duration, shape, or baseline level. Involvement of non-endoplasmic reticulum Ca 2+ stores, mainly mitochondria and the extracellular medium, participates in this fine tuning of Ca 2+ oscillations. The main characteristics of the Ca 2+ exchange fluxes with these compartments are also reviewed. PMID:27630768

  2. [Effect of polycarbophil Ca on IBS].

    Science.gov (United States)

    Mine, Tetsuya

    2006-08-01

    In this chapter, I mentioned the effect of polycarbophil Ca on IBS. IBS is classified into 3 types; diarrhea type, constipation type and combined type. Polycarbophil Ca is effective for all types of IBS.

  3. Short history of PACS. Part I: USA

    Energy Technology Data Exchange (ETDEWEB)

    Huang, H.K., E-mail: hkhuang@aol.com [Departments of Radiology and Biomedical Engineering, University of Southern California (United States); Hong Kong Polytechnic University (Hong Kong); Shanghai Institute of Technical Physics, Chinese Academy of Sciences (China)

    2011-05-15

    This historical review covers the PACS development in the USA during the past 28 years from 1982 to 2010. General historical remarks of PACS and international scene in three stages from infancy, puberty to adolescence are presented. Early PACS development was mostly financed by the federal government including the National Institutes of Health (NIH) and the U.S. Army Medical Research and Materiel Command. PACS evolution went through several stages. The earliest stages included the definition of large-scale PACS, establishment of the DICOM and other standards, the development of some early key PACS related technologies, and PACS implementation strategies. The later stages were in the concept of enterprise PACS, IHE (Integrating the Healthcare Enterprise) workflow profiles, and ePR with image distribution. The current most excited accomplishment is in the development of the new field in medical imaging informatics. This review goes through these stages and events in the USA during these 28 years, whenever an event involved participants from other countries, the contributors are cited.

  4. Mitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic islets.

    Science.gov (United States)

    Ainscow, E K; Rutter, G A

    2001-01-15

    Increases in mitochondrial [Ca(2+)] ([Ca(2+)](m)) have recently been reported to cause long-term alterations in cellular ATP production [Jouaville, Bastianutto, Rutter and Rizzuto (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 13807-13812]. We have determined the importance of this phenomenon for nutrient sensing in pancreatic islets and beta-cells by imaging adenovirally expressed Ca(2+) and ATP sensors (aequorin and firefly luciferase). [Ca(2+)](m) increases provoked by KCl or tolbutamide evoked an immediate increase in cytosolic and mitochondrial free ATP concentration ([ATP](c) and [ATP](m) respectively) at 3 mM glucose. Subsequent increases in [glucose] (to 16 or 30 mM) then caused a substantially larger increase in [ATP](c) and [ATP](m) than in naïve cells, and pre-stimulation with tolbutamide led to a larger secretory response in response to glucose. Whereas pre-challenge of islets with KCl altered the response to high [glucose] of [Ca(2+)](m) from periodic oscillations to a sustained elevation, oscillations in [ATP](c) were observed neither in naïve nor in stimulated islets. Hence, long-term potentiation of mitochondrial ATP synthesis is a central element in nutrient recognition by pancreatic islets.

  5. Barnacle muscle: Ca2+, activation and mechanics.

    Science.gov (United States)

    Ashley, C C; Griffiths, P J; Lea, T J; Mulligan, I P; Palmer, R E; Simnett, S J

    1993-01-01

    In this review, aspects of the ways in which Ca2+ is transported and regulated within muscle cells have been considered, with particular reference to crustacean muscle fibres. The large size of these fibres permits easy access to the internal environment of the cell, allowing it to be altered by microinjection or microperfusion. At rest, Ca2+ is not in equilibrium across the cell membrane, it enters the cell down a steep electrochemical gradient. The free [Ca2+] at rest is maintained at a value close to 200 nM by a combination of internal buffering systems, mainly the SR, mitochondria, and the fixed and diffusible Ca(2+)-binding proteins, as well as by an energy-dependent extrusion system operating across the external cell membrane. This system relies upon the inward movement of Na+ down its own electrochemical gradient to provide the energy for the extrusion of Ca2+ ions. As a result of electrical excitation, voltage-sensitive channels for Ca2+ are activated and permit Ca2+ to enter the cell more rapidly than at rest. It has been possible to determine both the amount of Ca2+ entering by this step, and what part this externally derived Ca2+ plays in the development of force as well as in the free Ca2+ change. The latter can be determined directly by Ca(2+)-sensitive indicators introduced into the cell sarcoplasm. A combination of techniques, allowing both the total and free Ca2+ changes to be assessed during electrical excitation, has provided valuable information as to how muscle cells buffer their Ca2+ in order to regulate the extent of the change in the free Ca2+ concentration. The data indicate that the entering Ca2+ can only make a small direct contribution to the force developed by the cell. The implication here is that the major source of Ca2+ for contraction must be derived from the internal Ca2+ storage sites within the SR system, a view reinforced by caged Ca2+ methods. The ability to measure the free Ca2+ concentration changes within a single cell during

  6. CA-CA互操作研究%Research of CA-CA Interoperability

    Institute of Scientific and Technical Information of China (English)

    沈士根; 叶培松; 陈宝明

    2005-01-01

    文章介绍了国际上CA-CA之间实现互操作的信任模式,然后根据中国目前的PKI实际情况,提出了以桥CA为全局模式,局部可采用严格层次信任模式来实现各CA之间的互操作.

  7. Altered network timing in the CA3-CA1 circuit of hippocampal slices from aged mice.

    Directory of Open Access Journals (Sweden)

    Daniel J Kanak

    Full Text Available Network patterns are believed to provide unique temporal contexts for coordinating neuronal activity within and across different regions of the brain. Some of the characteristics of network patterns modeled in vitro are altered in the CA3 or CA1 subregions of hippocampal slices from aged mice. CA3-CA1 network interactions have not been examined previously. We used slices from aged and adult mice to model spontaneous sharp wave ripples and carbachol-induced gamma oscillations, and compared measures of CA3-CA1 network timing between age groups. Coherent sharp wave ripples and gamma oscillations were evident in the CA3-CA1 circuit in both age groups, but the relative timing of activity in CA1 stratum pyramidale was delayed in the aged. In another sample of aged slices, evoked Schaffer collateral responses were attenuated in CA3 (antidromic spike amplitude and CA1 (orthodromic field EPSP slope. However, the amplitude and timing of spontaneous sharp waves recorded in CA1 stratum radiatum were similar to adults. In both age groups unit activity recorded juxtacellularly from unidentified neurons in CA1 stratum pyramidale and stratum oriens was temporally modulated by CA3 ripples. However, aged neurons exhibited reduced spike probability during the early cycles of the CA3 ripple oscillation. These findings suggest that aging disrupts the coordination of patterned activity in the CA3-CA1 circuit.

  8. An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis.

    Directory of Open Access Journals (Sweden)

    Wei Xiong

    Full Text Available AIM: Neurotransmitter release is elicited by an elevation of intracellular Ca(2+ concentration ([Ca(2+](i. The action potential triggers Ca(2+ influx through Ca(2+ channels which causes local changes of [Ca(2+](i for vesicle release. However, any direct role of extracellular Ca(2+ (besides Ca(2+ influx on Ca(2+-dependent exocytosis remains elusive. Here we set out to investigate this possibility on rat dorsal root ganglion (DRG neurons and chromaffin cells, widely used models for studying vesicle exocytosis. RESULTS: Using photolysis of caged Ca(2+ and caffeine-induced release of stored Ca(2+, we found that extracellular Ca(2+ inhibited exocytosis following moderate [Ca(2+](i rises (2-3 µM. The IC(50 for extracellular Ca(2+ inhibition of exocytosis (ECIE was 1.38 mM and a physiological reduction (∼30% of extracellular Ca(2+ concentration ([Ca(2+](o significantly increased the evoked exocytosis. At the single vesicle level, quantal size and release frequency were also altered by physiological [Ca(2+](o. The calcimimetics Mg(2+, Cd(2+, G418, and neomycin all inhibited exocytosis. The extracellular Ca(2+-sensing receptor (CaSR was not involved because specific drugs and knockdown of CaSR in DRG neurons did not affect ECIE. CONCLUSION/SIGNIFICANCE: As an extension of the classic Ca(2+ hypothesis of synaptic release, physiological levels of extracellular Ca(2+ play dual roles in evoked exocytosis by providing a source of Ca(2+ influx, and by directly regulating quantal size and release probability in neuronal cells.

  9. 3D point cloud data from laser scanning along the 2014 South Napa Earthquake surface rupture, California, USA

    Science.gov (United States)

    DeLong, Stephen B.

    2016-01-01

    Point cloud data collected along a 500 meter portion of the 2014 South Napa Earthquake surface rupture near Cuttings Wharf Road, Napa, CA, USA. The data include 7 point cloud files (.laz). The files are named with the location and date of collection and either ALSM for airborne laser scanner data or TLS for terrestrial laser scanner data. The ALSM data re previously released but are included here because they have been precisely aligned with the TLS data as described in the processing section of this metadata. 

  10. 77 FR 27082 - StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc., 1250 H Street, Greeley, CO...

    Science.gov (United States)

    2012-05-08

    ... Employment and Training Administration StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc... December 28, 2010, applicable to workers and former workers of StarTek USA, Inc., Greeley, Colorado. The...Tek USA, Inc. facilities in Greeley, Colorado (the ``west'' center at 244 Dundee Avenue and...

  11. Valitsus vaeb USA viisavabadusenõudeid / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2008-01-01

    USA viisavabaduse aluseks oleva vastastikuse mõistmise memorandumi projekt on täna valitsuse istungi päevakorras. Tšehhi ja USA on juba sõlminud kahepoolse memorandumi, mõnedel hinnangutel on Tšehhi järele andnud kogu ameeriklaste nõudmiste paketile. Lisa: Andmekaitsjad pole viimase seisuga kursis

  12. USA kliimamuutuse vastu: Kopenhaagenis ja edaspidi / Michael C. Polt

    Index Scriptorium Estoniae

    Polt, Michael C., 1954-

    2009-01-01

    Käsitledes Kopenhaageni kliimakonverentsi, märgib USA Eesti-suursaadik, et USA on valmis paika panema eesmärgi vähendada kohalike seadustega kooskõlas 2020. aastaks kasvuhoonegaaside heitmete emissiooni tasemeni, mis oleks 17% väiksem 2005. aasta tasemest

  13. Oletus : USA luurevanglad on Poolas ja Rumeenias / Krister Paris

    Index Scriptorium Estoniae

    Paris, Krister

    2005-01-01

    USA ajalehe Washington Post andmeil hoiab USA terrorismis kahtlustavaid Ida-Euroopa riikides. Poola ajalehe allikate väitel on üks neist riikidest Poola. Poola, Rumeenia, Bulgaaria tõrjuvad kahtlustusi, Tšehhi väitel on ameeriklaste palvele vange majutada ära öeldud

  14. School Psychology Research and Scholarship: USA Status, International Explorations.

    Science.gov (United States)

    Strein, William; Cramer, Katurah; Lawser, Matthew

    2003-01-01

    Addresses questions regarding research in school psychology by coding all of the articles published from 1994-1998 in the main USA school psychology journals and in "School Psychology International." Assessment-related topics and research on clinical/personality issues dominated the USA literature, while clinical/personality and professional…

  15. Valitsus vaeb USA viisavabadusenõudeid / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2008-01-01

    USA viisavabaduse aluseks oleva vastastikuse mõistmise memorandumi projekt on täna valitsuse istungi päevakorras. Tšehhi ja USA on juba sõlminud kahepoolse memorandumi, mõnedel hinnangutel on Tšehhi järele andnud kogu ameeriklaste nõudmiste paketile. Lisa: Andmekaitsjad pole viimase seisuga kursis

  16. Distribution, hosts and identification of Meloidogyne partityla in the USA

    Science.gov (United States)

    Pecan, Carya illinoensis, is an economically important nut crop and member of the Juglandaceae native to the southern USA. Discovered in South Africa in 1986, Meloidogyne partityla was first found infecting pecan in USA in 1996 and currently occurs in Texas, New Mexico, Georgia, Arizona, Oklahoma a...

  17. FY2015 Analysis of the Teamwork USA Program. Memorandum

    Science.gov (United States)

    Howard, Mark

    2015-01-01

    The Department of Research and Evaluation (DRE) has completed an analysis of the performance of students who participated in the Teamwork USA Program, administered in FY2014 at three District schools. Teamwork USA hopes to improve student achievement at select Title I elementary schools via its Instrumental Music Program grant. This memorandum to…

  18. Oletus : USA luurevanglad on Poolas ja Rumeenias / Krister Paris

    Index Scriptorium Estoniae

    Paris, Krister

    2005-01-01

    USA ajalehe Washington Post andmeil hoiab USA terrorismis kahtlustavaid Ida-Euroopa riikides. Poola ajalehe allikate väitel on üks neist riikidest Poola. Poola, Rumeenia, Bulgaaria tõrjuvad kahtlustusi, Tšehhi väitel on ameeriklaste palvele vange majutada ära öeldud

  19. USA üritab leida Teherani agente Iraagist / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2007-01-01

    USA süüdistab Iraani, et see abistab Iraagis mahdiste, mida juhib Muqtada al-Sadri. Autori sõnul on Iraani eliitüksuse Qudsi korpuse koostööd al-Sadriga aga sama vähe tõestatud kui omal ajal USA väidet Saddam Husseini ja al-Qaida vahel

  20. Siin ta siis ongi: USA õnnelikem inimene / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2011-01-01

    Uuringufirma Gallup ja tervise edendamisele pühendunud ettevõtte Healthways poolt läbiviidud uuringu käigus saadi teada, milline on statistiliselt USA kõige õnnelikum inimene. Ajaleht New York Times võttiski aluseks Gallupi andmed ja otsis üles statistilistelt näitajatelt kõige õnnelikuma USA inimese, kelleks osutus Alwin Wong

  1. Continental Tire to Build New Tire Plant in USA

    Institute of Scientific and Technical Information of China (English)

    Yuan Ye

    2012-01-01

    According to Tire Comments of USA, Continental Tire earlier announced that in order to meet the increasing market demand on replacement tires of USA, German Tire Company had negotiated and reached an agreement on production capacity expansion with the South Carolina Government.

  2. USA kliimamuutuse vastu: Kopenhaagenis ja edaspidi / Michael C. Polt

    Index Scriptorium Estoniae

    Polt, Michael C., 1954-

    2009-01-01

    Käsitledes Kopenhaageni kliimakonverentsi, märgib USA Eesti-suursaadik, et USA on valmis paika panema eesmärgi vähendada kohalike seadustega kooskõlas 2020. aastaks kasvuhoonegaaside heitmete emissiooni tasemeni, mis oleks 17% väiksem 2005. aasta tasemest

  3. 77 FR 38039 - Corporation for Travel Promotion (dba Brand USA)

    Science.gov (United States)

    2012-06-26

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF COMMERCE International Trade Administration Corporation for Travel Promotion (dba Brand USA) AGENCY: International Trade... membership on the Board of Directors of The Corporation for Travel Promotion (Board) (dba Brand USA)....

  4. Ruslands betændte forhold til USA

    DEFF Research Database (Denmark)

    Skak, Mette

    2015-01-01

    Rusland udgør en anden stormagtsudfordring for USA. Rusland er en stormagt i forfald, som imidlertid har genopfundet sin gamle sovjetiske 'Manifest Destiny'.......Rusland udgør en anden stormagtsudfordring for USA. Rusland er en stormagt i forfald, som imidlertid har genopfundet sin gamle sovjetiske 'Manifest Destiny'....

  5. Economic Diplomacy Formation of the Russian Empire Towards the USA

    Directory of Open Access Journals (Sweden)

    A G Savoyskiy

    2010-09-01

    Full Text Available This article focuses on relations between two great powers of the world - Russia and the USA. The early political and economic contacts between two countries and the place of the USA in economic diplomacy's formation of the Russian empire are examined.

  6. Mexico/USA. Magtkamp om muren er i gang

    DEFF Research Database (Denmark)

    Gelardi, Maiken

    2017-01-01

    Trump skaber nervøsitet i Mexico. Men vil et svagere Mexico få uoverskuelige konsekvenser for USA?......Trump skaber nervøsitet i Mexico. Men vil et svagere Mexico få uoverskuelige konsekvenser for USA?...

  7. Basque Diaspora in the USA and Language Maintenance

    Science.gov (United States)

    Lasagabaster, David

    2008-01-01

    The Basques first immigrated on a large scale to the USA during the Gold Rush of 1848. After immigrating to the USA, they settled in pockets throughout the West, especially in California, Nevada and Idaho, and it is currently estimated that more than 35,000 Basque-Americans live in these three states. This represents one of the largest…

  8. 46 CFR 7.130 - Point Conception, CA to Point Sur, CA.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Point Conception, CA to Point Sur, CA. 7.130 Section 7.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.130 Point Conception, CA to Point Sur, CA. (a) A line drawn from...

  9. Ameerikat sõtta õhutanud Iraagi prominent kaotas USA soosingu / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2004-01-01

    Iraaklase Ahmed Chalabi tegevusest ja lubadustest USA Iraagi-vastase sõja alustamiseks. USA toetuse kahanemisest Chalabile ja süüdistustest, et ta andis salajast infot Iraanile USA vägede tegevuse kohta Iraagis

  10. USA politoloogid : Obama võit oleks ka Eesti oma / Laura Vetik

    Index Scriptorium Estoniae

    Vetik, Laura

    2008-01-01

    USA politoloogide sõnul oleks pingestunud Venemaa ja USA suhete taustal Eestile kasulikum, kui 56. USA presidendivalimised võidaks demokraat Barack Obama. Erinevate politoloogide hinnanguid. Vt. samas: Obama ja McCain loovad kabinette

  11. Vaiksed professionaalid USA erivägedes on tulevased liidrid / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2006-01-01

    USA eriüksuste juhid kinnitavad esiterrorist Osama bin Ladeni peatset tabamist. Floridas Tampas asuvast USA Lähis-Ida operatsioonide peastaabist. Lisa: USA erioperatsioonide keskused. Vt. samas: Ameerika pikk ja väsitav sõda

  12. USA politoloogid : Obama võit oleks ka Eesti oma / Laura Vetik

    Index Scriptorium Estoniae

    Vetik, Laura

    2008-01-01

    USA politoloogide sõnul oleks pingestunud Venemaa ja USA suhete taustal Eestile kasulikum, kui 56. USA presidendivalimised võidaks demokraat Barack Obama. Erinevate politoloogide hinnanguid. Vt. samas: Obama ja McCain loovad kabinette

  13. President Meri näitas USA-le vabaduse ilu / Daniel Fried ; interv. Kaarel Kaas

    Index Scriptorium Estoniae

    Fried, Daniel, 1952-

    2006-01-01

    USA abivälisminister Daniel Fried USA välispoliitika ühest eesmärgist - demokraatia levitamisest maailmas, demokraatia olukorrast Venemaal ning USA ja Venemaa vahelistest suhetest. Lisa: Daniel Fried

  14. President Meri näitas USA-le vabaduse ilu / Daniel Fried ; interv. Kaarel Kaas

    Index Scriptorium Estoniae

    Fried, Daniel, 1952-

    2006-01-01

    USA abivälisminister Daniel Fried USA välispoliitika ühest eesmärgist - demokraatia levitamisest maailmas, demokraatia olukorrast Venemaal ning USA ja Venemaa vahelistest suhetest. Lisa: Daniel Fried

  15. USA ja EL vähendavad kaubandustõkkeid / Kertu Ruus

    Index Scriptorium Estoniae

    Ruus, Kertu, 1977-

    2005-01-01

    Tippkohtumisel Washingtonis arutasid Euroopa Komisjoni president Jose Manuel Barroso ja USA president George W. Bush, kuidas EL-i ja USA majandussuhteid vabamaks muuta. Diagramm: EL-i kaubavahetus USA-ga

  16. Testing coral paleothermometers (B/Ca, Mg/Ca, Sr/Ca, U/Ca andδ18O) under impacts of large riverine runoff

    Institute of Scientific and Technical Information of China (English)

    CHEN Tianran; YU Kefu; ZHAO Jianxin; YAN Hongqiang; SONG Yinxian; FENG Yuexing; CHEN Tegu

    2015-01-01

    Sea surface temperature (SST) proxies including B/Ca, Mg/Ca, Sr/Ca, U/Ca andδ18O were analyzed in the skeleton of aPorites coral collected from the Zhujiang River (Pearl River) Estuary (ZRE). These geochemical proxies are influenced by river runoff and this area of the northern South China Sea is strongly affected by seasonal freshwater floods. We assessed the robustness of each SST proxy through comparison with the local instrumental SST. Coral Sr/Ca shows the highest correlation with SST variations (r2=0.59), suggesting Sr/Ca is the most robust SST proxy. In contrast, coralδ18O (r2=0.46), B/Ca (r2=0.43) and U/Ca (r2=0.41) ratios were only moderately correlated with SST variations, suggesting that they are disturbed by some other factors in addition to SST. The poor correlation (r2=0.27) between SST and Mg/Ca indicates that Mg/Ca in coral skeletons is not a simple function of SST variations. This may ultimately limit the use of Mg/Ca as a coral paleothermometer.

  17. Multiple Ca2+ sensors in secretion

    DEFF Research Database (Denmark)

    Walter, Alexander M; Groffen, Alexander J; Sørensen, Jakob Balslev;

    2011-01-01

    Regulated neurotransmitter secretion depends on Ca(2+) sensors, C2 domain proteins that associate with phospholipids and soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) complexes to trigger release upon Ca(2+) binding. Ca(2+) sensors are thought to prevent spontaneous...... fusion at rest (clamping) and to promote fusion upon Ca(2+) activation. At least eight, often coexpressed, Ca(2+) sensors have been identified in mammals. Accumulating evidence suggests that multiple Ca(2+) sensors interact, rather than work autonomously, to produce the complex secretory response...... observed in neurons and secretory cells. In this review, we present several working models to describe how different sensors might be arranged to mediate synchronous, asynchronous and spontaneous neurotransmitter release. We discuss the scenario that different Ca(2+) sensors typically act on one shared...

  18. Paragonimus kellicotti flukes in Missouri, USA.

    Science.gov (United States)

    Lane, Michael A; Marcos, Luis A; Onen, Nur F; Demertzis, Lee M; Hayes, Ericka V; Davila, Samuel Z; Nurutdinova, Diana R; Bailey, Thomas C; Weil, Gary J

    2012-08-01

    Paragonimiasis is an infection caused by lung flukes of the genus Paragonimus. In Asia, P. westermani infections are relatively common because of dietary practices. However, in North America, cases of paragonimiasis, which are caused by P. kellicotti flukes, are rare. Only 7 autochthonous cases of paragonimiasis were reported during 1968-2008. In 2009, we reported 3 new case-patients with paragonimiasis who had been seen at our medical center over an 18-month period. Six additional case-patients were identified in St. Louis, Missouri, USA, and treated at Washington University-affiliated health centers in 2009-2010. We report detailed descriptions of these case-patients, which includes unusual clinical manifestations. We also describe public health interventions that were undertaken to inform the general public and physicians about the disease and its mode of transmission.

  19. [Murder. Italy-USA comparative profiles].

    Science.gov (United States)

    Palermo, George B; Mastronardi, Vincenzo

    2012-01-01

    This paper, through illustrative cases of homicidal typologies, examines the generally accepted theories on the subject: 1) sociological ones by Lorenz to Sutherland and Cressey, by Berkowitz to Wolfgang and Ferracuti and others; 2) neurobiological ones, which include the involvement of the limbic, hippocampal and parietal lobes of the brain; 3) the psychological (psychodynamic) ones which are not disjoint from the types of individual criminal homicide and related aspects. In the discussion of the types of murders, family and extrafamilial murders are then taken into consideration, with the various meanings of revenge, challenge, other reasons linked to robbery, theft, settling scores leading to youth gangs and drive-by-shootings of marginalized adolescents, crimes related to drugs and to mental disorders. Infanticide and multiple murder, including mass murder and serial killer, conclude the work together with the statistics of murders and family murders in Italy compared to USA, specifically to the crime clock.

  20. Review: Grigoleit, Grit: Integrationsvarianten. Die Hmong in den USA (2008 Buchbesprechung: Grigoleit, Grit: Integrationsvarianten. Die Hmong in den USA (2008

    Directory of Open Access Journals (Sweden)

    Hans-Bernd Zöllner

    2009-07-01

    Full Text Available Review of the monograph: Grigoleit, Grit (2008, Integrationsvarianten. Die Hmong in den USA, Passau: Verlag Karl Stutz, ISBN 978-3-88849-183-2, 250 pages Besprechung der Monographie: Grigoleit, Grit (2008, Integrationsvarianten. Die Hmong in den USA, Passau: Verlag Karl Stutz, ISBN 978-3-88849-183-2, 250 Seiten

  1. Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strength.

    Science.gov (United States)

    Barcomb, Kelsey; Buard, Isabelle; Coultrap, Steven J; Kulbe, Jacqueline R; O'Leary, Heather; Benke, Timothy A; Bayer, K Ulrich

    2014-08-01

    A hallmark feature of Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) is generation of autonomous (Ca(2+)-independent) activity by T286 autophosphorylation. Biochemical studies have shown that "autonomous" CaMKII is ∼5-fold further stimulated by Ca(2+)/CaM, but demonstration of a physiological function for such regulation within cells has remained elusive. In this study, CaMKII-induced enhancement of synaptic strength in rat hippocampal neurons required both autonomous activity and further stimulation. Synaptic strength was decreased by CaMKIIα knockdown and rescued by reexpression, but not by mutants impaired for autonomy (T286A) or binding to NMDA-type glutamate receptor subunit 2B (GluN2B; formerly NR2B; I205K). Full rescue was seen with constitutively autonomous mutants (T286D), but only if they could be further stimulated (additional T305/306A mutation), and not with two other mutations that additionally impair Ca(2+)/CaM binding. Compared to rescue with wild-type CaMKII, the CaM-binding-impaired mutants even had reduced synaptic strength. One of these mutants (T305/306D) mimicked an inhibitory autophosphorylation of CaMKII, whereas the other one (Δstim) abolished CaM binding without introducing charged residues. Inhibitory T305/306 autophosphorylation also reduced GluN2B binding, but this effect was independent of reduced Ca(2+)/CaM binding and was not mimicked by T305/306D mutation. Thus, even autonomous CaMKII activity must be further stimulated by Ca(2+)/CaM for enhancement of synaptic strength.

  2. When is high-Ca+ microdomain required for mitochondrial Ca+ uptake?

    Science.gov (United States)

    Spät, A; Fülöp, L; Koncz, P; Szanda, G

    2009-01-01

    Ca(2+) release from IP(3)-sensitive stores in the endoplasmic reticulum (ER) induced by Ca(2+)-mobilizing agonists generates high-Ca(2+) microdomains between ER vesicles and neighbouring mitochondria. Here we present a model that describes when such microdomains are required and when submicromolar [Ca(2+)] is sufficient for mitochondrial Ca(2+) uptake. Mitochondrial Ca(2+) uptake rate in angiotensin II-stimulated H295R adrenocortical cells correlates with the proximity between ER vesicles and the mitochondrion, reflecting the uptake promoting effect of high-Ca(2+) peri-mitochondrial microdomains. Silencing or inhibition of p38 mitogen-activated protein kinase (MAPK) or inhibition of the novel isoforms of protein kinase C enhances mitochondrial Ca(2+) uptake and abolishes the positive correlation between Ca(2+) uptake and ER-mitochondrion proximity. Inhibition of protein phosphatases attenuates mitochondrial Ca(2+) uptake and also abolishes its positive correlation with ER-mitochondrion proximity. We postulate that during IP(3)-induced Ca(2+) release, Ca(2+) uptake is confined to ER-close mitochondria, because of the simultaneous activation of the protein kinases. Attenuation of Ca(2+) uptake prevents Ca(2+) overload of mitochondria and thus protects the cell against apoptosis. On the other hand, all the mitochondria accumulate Ca(2+) at a non-inhibited rate during physiological Ca(2+) influx through the plasma membrane. Membrane potential is higher in ER-distant mitochondria, providing a bigger driving force for Ca(2+) uptake. Our model explains why comparable mitochondrial Ca(2+) signals are formed in response to K(+) and angiotensin II (equipotent in respect to global cytosolic Ca(2+) signals), although only the latter generates high-Ca(2+) microdomains.

  3. Photosynthetic and growth response of sugar maple (Acer saccharum Marsh.) mature trees and seedlings to calcium, magnesium, and nitrogen additions in the Catskill Mountains, NY, USA

    Science.gov (United States)

    Momen, Bahram; Behling, Shawna J; Lawrence, Gregory B.; Sullivan, Joseph H

    2015-01-01

    Decline of sugar maple in North American forests has been attributed to changes in soil calcium (Ca) and nitrogen (N) by acidic precipitation. Although N is an essential and usually a limiting factor in forests, atmospheric N deposition may cause N-saturation leading to loss of soil Ca. Such changes can affect carbon gain and growth of sugar maple trees and seedlings. We applied a 22 factorial arrangement of N and dolomitic limestone containing Ca and Magnesium (Mg) to 12 forest plots in the Catskill Mountain region of NY, USA. To quantify the short-term effects, we measured photosynthetic-light responses of sugar maple mature trees and seedlings two or three times during two summers. We estimated maximum net photosynthesis (An-max) and its related light intensity (PAR at An-max), apparent quantum efficiency (Aqe), and light compensation point (LCP). To quantify the long-term effects, we measured basal area of living mature trees before and 4 and 8 years after treatment applications. Soil and foliar chemistry variables were also measured. Dolomitic limestone increased Ca, Mg, and pH in the soil Oe horizon. Mg was increased in the B horizon when comparing the plots receiving N with those receiving CaMg. In mature trees, foliar Ca and Mg concentrations were higher in the CaMg and N+CaMg plots than in the reference or N plots; foliar Ca concentration was higher in the N+CaMg plots compared with the CaMg plots, foliar Mg was higher in the CaMg plots than the N+CaMg plots; An-max was maximized due to N+CaMg treatment; Aqe decreased by N addition; and PAR at An-max increased by N or CaMg treatments alone, but the increase was maximized by their combination. No treatment effect was detected on basal areas of living mature trees four or eight years after treatment applications. In seedlings, An-max was increased by N+CaMg addition. The reference plots had an open herbaceous layer, but the plots receiving N had a dense monoculture of common woodfern in the

  4. Photosynthetic and Growth Response of Sugar Maple (Acer saccharum Marsh. Mature Trees and Seedlings to Calcium, Magnesium, and Nitrogen Additions in the Catskill Mountains, NY, USA.

    Directory of Open Access Journals (Sweden)

    Bahram Momen

    Full Text Available Decline of sugar maple in North American forests has been attributed to changes in soil calcium (Ca and nitrogen (N by acidic precipitation. Although N is an essential and usually a limiting factor in forests, atmospheric N deposition may cause N-saturation leading to loss of soil Ca. Such changes can affect carbon gain and growth of sugar maple trees and seedlings. We applied a 22 factorial arrangement of N and dolomitic limestone containing Ca and Magnesium (Mg to 12 forest plots in the Catskill Mountain region of NY, USA. To quantify the short-term effects, we measured photosynthetic-light responses of sugar maple mature trees and seedlings two or three times during two summers. We estimated maximum net photosynthesis (An-max and its related light intensity (PAR at An-max, apparent quantum efficiency (Aqe, and light compensation point (LCP. To quantify the long-term effects, we measured basal area of living mature trees before and 4 and 8 years after treatment applications. Soil and foliar chemistry variables were also measured. Dolomitic limestone increased Ca, Mg, and pH in the soil Oe horizon. Mg was increased in the B horizon when comparing the plots receiving N with those receiving CaMg. In mature trees, foliar Ca and Mg concentrations were higher in the CaMg and N+CaMg plots than in the reference or N plots; foliar Ca concentration was higher in the N+CaMg plots compared with the CaMg plots, foliar Mg was higher in the CaMg plots than the N+CaMg plots; An-max was maximized due to N+CaMg treatment; Aqe decreased by N addition; and PAR at An-max increased by N or CaMg treatments alone, but the increase was maximized by their combination. No treatment effect was detected on basal areas of living mature trees four or eight years after treatment applications. In seedlings, An-max was increased by N+CaMg addition. The reference plots had an open herbaceous layer, but the plots receiving N had a dense monoculture of common woodfern in the

  5. 76 FR 65710 - Decision and Order Amending Waivers Granted to Mitsubishi Electric & Electronics USA, Inc. From...

    Science.gov (United States)

    2011-10-24

    ... Electric & Electronics USA, Inc. From the Department of Energy Commercial Package Air Conditioner and Heat... Matter of: Mitsubishi Electric & Electronics USA, Inc. (Mitsubishi) (Case No. CAC-037). Background...

  6. Iowa valus hoop Hillary Clintonile segas USA presidendivalimistel kaarte / Liisi Poll

    Index Scriptorium Estoniae

    Poll, Liisi, 1980-

    2008-01-01

    USA presidendivalimiste eelvalimistel võitis demokraat Barack Obama. Presidendikandidaatide seisukohtadest. Tabel: USA presidendivalimised. Tulemused Iowas. Vt. samas: Tähtsaimaks osutusid majandus ja Iraagi sõda

  7. Medierne tager stilling : de amerikanske mediers rolle under USA's krige i det tyvende århundrede

    DEFF Research Database (Denmark)

    Pedersen, Carl George

    2005-01-01

    USA ; medier ; krige ; nyhedsformidling ; journalistik ; pressedækning ; krigsjournalistik ; historie......USA ; medier ; krige ; nyhedsformidling ; journalistik ; pressedækning ; krigsjournalistik ; historie...

  8. Iowa valus hoop Hillary Clintonile segas USA presidendivalimistel kaarte / Liisi Poll

    Index Scriptorium Estoniae

    Poll, Liisi, 1980-

    2008-01-01

    USA presidendivalimiste eelvalimistel võitis demokraat Barack Obama. Presidendikandidaatide seisukohtadest. Tabel: USA presidendivalimised. Tulemused Iowas. Vt. samas: Tähtsaimaks osutusid majandus ja Iraagi sõda

  9. In Situ Ca2+ Titration in the Fluorometric Study of Intracellular Ca2+ Binding

    Science.gov (United States)

    McMahon, Shane M.; Jackson, Meyer B.

    2014-01-01

    Imaging with Ca2+-sensitive fluorescent dye has provided a wealth of insight into the dynamics of cellular Ca2+ signaling. The spatiotemporal evolution of intracellular free Ca2+ observed in imaging experiments is shaped by binding and unbinding to cytoplasmic Ca2+ buffers, as well as the fluorescent indicator used for imaging. These factors must be taken into account in the interpretation of Ca2+ imaging data, and can be exploited to investigate endogenous Ca2+ buffer properties. Here we extended the use of Ca2+ fluorometry in the characterization of Ca2+ binding molecules within cells, building on a method of titration of intracellular Ca2+ binding sites in situ with measured amounts of Ca2+ entering through voltage-gated Ca2+ channels. We developed a systematic procedure for fitting fluorescence data acquired during a series of voltage steps to models with multiple Ca2+ binding sites. The method was tested on simulated data, and then applied to 2-photon fluorescence imaging data from rat posterior pituitary nerve terminals patch clamp-loaded with the Ca2+ indicator fluo-8. Focusing on data sets well described by a single endogenous Ca2+ buffer and dye, this method yielded estimates of the endogenous buffer concentration and Kd, the dye Kd, and the fraction of Ca2+ inaccessible cellular volume. The in situ Kd of fluo-8 thus obtained was indistinguishable from that measured in vitro. This method of calibrating Ca2+-sensitive fluorescent dyes in situ has significant advantages over previous methods. Our analysis of Ca2+ titration fluorometric data makes more effective use of the experimental data, and provides a rigorous treatment of multivariate errors and multiple Ca2+ binding species. This method offers a versatile approach to the study of endogenous Ca2+ binding molecules in their physiological milieu. PMID:25465896

  10. Involvement of Ca2+/CaM in the signal transduction of acetylcholine regulating stomatal movement

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    It has been known that the neurotransmitter acetylcholine (ACh) also exists in plants and is able to regulate the movement of stomata. In another aspect, Ca2+/CaM as the second messengers have a critical role of signal transduction in stomatal guard-cell. Here we showed that Ca2+/CaM were also involved in theACh regulated stomatal movement. In the medium containing Ca2+, the Ca2+ channel blockers (NIF and Ver) and CaM inhibitors (TFP and W7) could neutralize the ACh induced stomatal opening, however, they are ineffective in the medium containing K+. Those results indicated that Ca2+/CaM were involved in the signal transduction pathway of ACh regulating stomatal movement.

  11. Influence of NaCl-CaCl2 on Decomposing REPO4 with CaO

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The influence of NaCl-CaCl2 on thermal decomposition of REPO4 (RE: Ce, La, Nd, Th) with CaO was studied.The heat decomposing process of REPO4 was tested with TG-DTA experiments.The results showed that the decomposition temperature of REPO4 with CaO was reduced because of adding NaCl-CaCl2 mixture (NaCl:CaCl2=1:1).The influence of the addition of NaCl-CaCl2, roasting temperature and roasting time on decomposition ratio of REPO4 with CaO was studied.The results showed that the decomposition ratio of REPO4with CaO was 79% when the addition percentage of NaCl-CaCl2 was 10%, the roasting temperature was 750℃, and the roasting time was 1 h.

  12. Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis.

    Directory of Open Access Journals (Sweden)

    Xiao-Chen Li

    Full Text Available Heart tissues from hibernating mammals, such as ground squirrels, are able to endure hypothermia, hypoxia and other extreme insulting factors that are fatal for human and nonhibernating mammals. This study was designed to understand adaptive mechanisms involved in intracellular Ca(2+ homeostasis in cardiomyocytes from the mammalian hibernator, ground squirrel, compared to rat. Electrophysiological and confocal imaging experiments showed that the voltage-dependence of L-type Ca(2+ current (I(Ca was shifted to higher potentials in ventricular myocytes from ground squirrels vs. rats. The elevated threshold of I(Ca did not compromise the Ca(2+-induced Ca(2+ release, because a higher depolarization rate and a longer duration of action potential compensated the voltage shift of I(Ca. Both the caffeine-sensitive and caffeine-resistant components of cytosolic Ca(2+ removal were more rapid in ground squirrels. Ca(2+ sparks in ground squirrels exhibited larger amplitude/size and much lower frequency than in rats. Due to the high I(Ca threshold, low SR Ca(2+ leak and rapid cytosolic Ca(2+ clearance, heart cells from ground squirrels exhibited better capability in maintaining intracellular Ca(2+ homeostasis than those from rats and other nonhibernating mammals. These findings not only reveal adaptive mechanisms of hibernation, but also provide novel strategies against Ca(2+ overload-related heart diseases.

  13. Ameerika suursaadik Aldona Sofia Wos : toon kättpidi USA suurfirmad Eestisse / Aldona Zofia Wos ; interv. Airi Ilisson

    Index Scriptorium Estoniae

    Wos, Aldona Zofia

    2005-01-01

    USA suursaadik Eestis vastab küsimustele, mis on seotud Londonis USA riigidepartemangu korraldatud konverentsiga, kus Balti riikide juhid rääkisid USA ettevõtete esindajatele, miks tuleks investeerida Balti riikidesse. USA tehtud investeeringutest Eestisse, Eesti ettevõtjate võimalustest USA-s. Lisa: Tõhus rahapüüdja

  14. Ameerika suursaadik Aldona Sofia Wos : toon kättpidi USA suurfirmad Eestisse / Aldona Zofia Wos ; interv. Airi Ilisson

    Index Scriptorium Estoniae

    Wos, Aldona Zofia

    2005-01-01

    USA suursaadik Eestis vastab küsimustele, mis on seotud Londonis USA riigidepartemangu korraldatud konverentsiga, kus Balti riikide juhid rääkisid USA ettevõtete esindajatele, miks tuleks investeerida Balti riikidesse. USA tehtud investeeringutest Eestisse, Eesti ettevõtjate võimalustest USA-s. Lisa: Tõhus rahapüüdja

  15. γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression.

    Science.gov (United States)

    Ma, Huan; Groth, Rachel D; Cohen, Samuel M; Emery, John F; Li, Boxing; Hoedt, Esthelle; Zhang, Guoan; Neubert, Thomas A; Tsien, Richard W

    2014-10-09

    Activity-dependent CREB phosphorylation and gene expression are critical for long-term neuronal plasticity. Local signaling at CaV1 channels triggers these events, but how information is relayed onward to the nucleus remains unclear. Here, we report a mechanism that mediates long-distance communication within cells: a shuttle that transports Ca(2+)/calmodulin from the surface membrane to the nucleus. We show that the shuttle protein is γCaMKII, its phosphorylation at Thr287 by βCaMKII protects the Ca(2+)/CaM signal, and CaN triggers its nuclear translocation. Both βCaMKII and CaN act in close proximity to CaV1 channels, supporting their dominance, whereas γCaMKII operates as a carrier, not as a kinase. Upon arrival within the nucleus, Ca(2+)/CaM activates CaMKK and its substrate CaMKIV, the CREB kinase. This mechanism resolves long-standing puzzles about CaM/CaMK-dependent signaling to the nucleus. The significance of the mechanism is emphasized by dysregulation of CaV1, γCaMKII, βCaMKII, and CaN in multiple neuropsychiatric disorders.

  16. 77 FR 15395 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-OPEN MOBILE ALLIANCE

    Science.gov (United States)

    2012-03-15

    ... Limited, Cambridge, UNITED KINGDOM; Cybage Software Private Limited, Pune, Maharashtra, INDIA; DGIST... Internet, S.A.U., Madrid, SPAIN; GoldSpot Media Inc., Sunnyvale, CA; Handmark, Inc., Kansas City, MI...

  17. 78 FR 77713 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Science.gov (United States)

    2013-12-24

    ..., Inc. of Sunnyvale, CA; Samsung Electronics Co., Ltd of South Korea; Samsung Electronics America, Inc. of Ridgefield Park, NJ; Samsung Telecommunications America, L.L.C. of Richardson, TX; Sony...

  18. Dissection of local Ca(2+) signals inside cytosol by ER-targeted Ca(2+) indicator.

    Science.gov (United States)

    Niwa, Fumihiro; Sakuragi, Shigeo; Kobayashi, Ayana; Takagi, Shin; Oda, Yoichi; Bannai, Hiroko; Mikoshiba, Katsuhiko

    2016-10-07

    Calcium (Ca(2+)) is a versatile intracellular second messenger that operates in various signaling pathways leading to multiple biological outputs. The diversity of spatiotemporal patterns of Ca(2+) signals, generated by the coordination of Ca(2+) influx from the extracellular space and Ca(2+) release from the intracellular Ca(2+) store the endoplasmic reticulum (ER), is considered to underlie the diversity of biological outputs caused by a single signaling molecule. However, such Ca(2+) signaling diversity has not been well described because of technical limitations. Here, we describe a new method to report Ca(2+) signals at subcellular resolution. We report that OER-GCaMP6f, a genetically encoded Ca(2+) indicator (GECI) targeted to the outer ER membrane, can monitor Ca(2+) release from the ER at higher spatiotemporal resolution than conventional GCaMP6f. OER-GCaMP6f was used for in vivo Ca(2+) imaging of C. elegans. We also found that the spontaneous Ca(2+) elevation in cultured astrocytes reported by OER-GCaMP6f showed a distinct spatiotemporal pattern from that monitored by plasma membrane-targeted GCaMP6f (Lck-GCaMP6f); less frequent Ca(2+) signal was detected by OER-GCaMP6f, in spite of the fact that Ca(2+) release from the ER plays important roles in astrocytes. These findings suggest that targeting of GECIs to the ER outer membrane enables sensitive detection of Ca(2+) release from the ER at subcellular resolution, avoiding the diffusion of GECI and Ca(2+). Our results indicate that Ca(2+) imaging with OER-GCaMP6f in combination with Lck-GCaMP6f can contribute to describing the diversity of Ca(2+) signals, by enabling dissection of Ca(2+) signals at subcellular resolution.

  19. Robertsite, Ca2MnIII3O2(PO43·3H2O

    Directory of Open Access Journals (Sweden)

    Marcelo B. Andrade

    2012-10-01

    Full Text Available Robertsite, ideally Ca2Mn3O2(PO43·3H2O [calcium manganese(III tris(orthophosphate trihydrate], can be associated with the arseniosiderite structural group characterized by the general formula Ca2A3O2(TO43·nH2O, with A = Fe, Mn; T = As, P; and n = 2 or 3. In this study, single-crystal X-ray diffraction data were used to determine the robertsite structure from a twinned crystal from the type locality, the Tip Top mine, Custer County, South Dakota, USA, and to refine anisotropic displacement parameters for all atoms. The general structural feature of robertsite resembles that of the other two members of the arseniosiderite group, the structures of which have previously been reported. It is characterized by sheets of [MnO6] octahedra in the form of nine-membered pseudo-trigonal rings. Located at the center of each nine-membered ring is a PO4 tetrahedron, and the other eight PO4 tetrahedra sandwich the Mn–oxide sheets. The six different Ca2+ ions are seven-coordinated in form of distorted pentagonal bipyramids, [CaO5(H2O2], if Ca—O distances less than 2.85 Å are considered. Along with hydrogen bonding involving the water molecules, they hold the manganese–phosphate sheets together. All nine [MnO6] octahedra are distorted by the Jahn–Teller effect.

  20. Ca isotope stratigraphy across the Cenomanian-Turonian OAE 2: Links between volcanism, seawater geochemistry, and the carbonate fractionation factor

    Science.gov (United States)

    Du Vivier, Alice D. C.; Jacobson, Andrew D.; Lehn, Gregory O.; Selby, David; Hurtgen, Matthew T.; Sageman, Bradley B.

    2015-04-01

    The Ca isotope composition of marine carbonate rocks offers potential to reconstruct drivers of environmental change in the geologic past. This study reports new, high-precision Ca isotope records (δ44/40Ca; 2σSD = ± 0.04 ‰) for three sections spanning a major perturbation to the Cretaceous ocean-climate system known as Ocean Anoxic Event 2 (OAE 2): central Colorado, USA (Portland #1 core), southeastern France (Pont d'Issole), and Hokkaido, Japan (Oyubari, Yezo Group). In addition, we generated new data for selected samples from Eastbourne, England (English Chalk), where a previous Ca isotope study was completed using different methodology (Blättler et al., 2011). Strata of the Yezo Group contain little carbonate (∼1 wt.% on average) and accordingly did not yield a clear δ44/40Ca signal. The Portland core and the Pont d'Issole section display comparable δ44/40Ca values, which increase by ∼ 0.10- 0.15 ‰ at the onset of OAE 2 and then decrease to near-initial values across the event. The Eastbourne δ44/40Ca values are higher than previously reported. They are also higher than the δ44/40Ca values for the Portland core and the Pont d'Issole section but define a similar pattern. According to a numerical model of the marine Ca cycle, elevated hydrothermal inputs have little impact on seawater δ44/40Ca values. Elevated riverine (chemical weathering) inputs produce a transient negative isotope excursion, which significantly differs from the positive isotope excursions observed in the Portland, Pont d'Issole, and Eastbourne records. A decrease in the magnitude of the carbonate fractionation factor provides the best explanation for a positive shift in δ44/40Ca values, especially given the rapid nature of the excursion. Because a decrease in the fractionation factor corresponds to an increase in the Ca/CO3 ratio of seawater, we tentatively attribute the positive Ca isotope excursion to transient ocean acidification, i.e., a reduction in the concentration of

  1. Ca2+ uptake by the endoplasmic reticulum Ca2+-ATPase in rat microvascular endothelial cells.

    Science.gov (United States)

    Moccia, Francesco; Berra-Romani, Roberto; Baruffi, Silvana; Spaggiari, Santina; Signorelli, Silvia; Castelli, Loretta; Magistretti, Jacopo; Taglietti, Vanni; Tanzi, Franco

    2002-01-01

    In non-excitable cells, many agonists increase the intracellular Ca(2+) concentration ([Ca(2+)](i)) by inducing an inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release from the intracellular stores. Ca(2+) influx from the extracellular medium may then sustain the Ca(2+) signal. [Ca(2+)](i) recovers its resting level as a consequence of Ca(2+)-removing mechanisms, i.e. plasma-membrane Ca(2+)-ATPase (PMCA) pump, Na(+)/Ca(2+) exchanger (NCX) and sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump. In a study performed in pancreatic acinar cells, evidence has been provided suggesting that, during the decay phase of the agonist-evoked Ca(2+) transients, the Ca(2+) concentration within the intracellular stores remains essentially constant [Mogami, Tepikin and Petersen (1998) EMBO J. 17, 435-442]. It was therefore hypothesized that, in such a situation, intracellular Ca(2+) is not only picked up by the SERCA pump, but is also newly released through IP(3)-sensitive Ca(2+) channels, with the balance between these two processes being approximately null. The main aim of the present work was to test this hypothesis by a different experimental approach. Using cardiac microvascular endothelial cells, we found that inhibition of the SERCA pump has no effect on the time course of agonist-evoked Ca(2+) transients. This result was not due to a low capacity of the SERCA pump since, after agonist removal, this pump proved to be very powerful in clearing the excess of intracellular Ca(2+). We showed further that: (i) in order to avoid a rapid removal of Ca(2+) by the SERCA pump, continuous IP(3) production appears to be required throughout all of the decay phase of the Ca(2+) transient; and (ii) Ca(2+) picked up by the SERCA pump can be fully and immediately released by agonist application. All these results support the model of Mogami, Tepikin and Petersen [(1998) EMBO J. 17, 435-442]. Since the SERCA pump did not appear to be involved in shaping the decay phase of the

  2. Localized Calcineurin Confers Ca2+-Dependent Inactivation Upon Neuronal L-Type Ca2+ Channels

    OpenAIRE

    2012-01-01

    Excitation-driven entry of Ca2+ through L-type voltage-gated Ca2+ channels controls gene expression in neurons and a variety of fundamental activities in other kinds of excitable cells. The probability of opening of CaV1.2 L-type channels is subject to pronounced enhancement by cAMP-dependent protein kinase (PKA), which is scaffolded to CaV1.2 channels by A-kinase anchoring proteins (AKAPs). CaV1.2 channels also undergo negative autoregulation via Ca2+-dependent inactivation (CDI), which stro...

  3. Interlamellar CA1 network in the hippocampus

    OpenAIRE

    Yang, Sunggu; Yang, Sungchil; Moreira, Thais; Hoffman, Gloria; Carlson, Greg C.; Bender, Kevin J.; Alger, Bradley E.; Tang, Cha-Min

    2014-01-01

    It has generally been thought that CA1 cells form only negligible connections with each other along the longitudinal axis of the hippocampus. But if CA1 cells were interconnected in an effective autoassociational network, this information would add a critical new dimension to our understanding of cellular processing within this structure. Here, we report the existence of a well-organized, longitudinally projecting synaptic network among CA1 pyramidal neurons. We further show that synapses of ...

  4. Glutamate excitotoxicity and Ca2+-regulation of respiration: Role of the Ca2+ activated mitochondrial transporters (CaMCs).

    Science.gov (United States)

    Rueda, Carlos B; Llorente-Folch, Irene; Traba, Javier; Amigo, Ignacio; Gonzalez-Sanchez, Paloma; Contreras, Laura; Juaristi, Inés; Martinez-Valero, Paula; Pardo, Beatriz; Del Arco, Araceli; Satrustegui, Jorgina

    2016-08-01

    Glutamate elicits Ca(2+) signals and workloads that regulate neuronal fate both in physiological and pathological circumstances. Oxidative phosphorylation is required in order to respond to the metabolic challenge caused by glutamate. In response to physiological glutamate signals, cytosolic Ca(2+) activates respiration by stimulation of the NADH malate-aspartate shuttle through Ca(2+)-binding to the mitochondrial aspartate/glutamate carrier (Aralar/AGC1/Slc25a12), and by stimulation of adenine nucleotide uptake through Ca(2+) binding to the mitochondrial ATP-Mg/Pi carrier (SCaMC-3/Slc25a23). In addition, after Ca(2+) entry into the matrix through the mitochondrial Ca(2+) uniporter (MCU), it activates mitochondrial dehydrogenases. In response to pathological glutamate stimulation during excitotoxicity, Ca(2+) overload, reactive oxygen species (ROS), mitochondrial dysfunction and delayed Ca(2+) deregulation (DCD) lead to neuronal death. Glutamate-induced respiratory stimulation is rapidly inactivated through a mechanism involving Poly (ADP-ribose) Polymerase-1 (PARP-1) activation, consumption of cytosolic NAD(+), a decrease in matrix ATP and restricted substrate supply. Glutamate-induced Ca(2+)-activation of SCaMC-3 imports adenine nucleotides into mitochondria, counteracting the depletion of matrix ATP and the impaired respiration, while Aralar-dependent lactate metabolism prevents substrate exhaustion. A second mechanism induced by excitotoxic glutamate is permeability transition pore (PTP) opening, which critically depends on ROS production and matrix Ca(2+) entry through the MCU. By increasing matrix content of adenine nucleotides, SCaMC-3 activity protects against glutamate-induced PTP opening and lowers matrix free Ca(2+), resulting in protracted appearance of DCD and protection against excitotoxicity in vitro and in vivo, while the lack of lactate protection during in vivo excitotoxicity explains increased vulnerability to kainite-induced toxicity in Aralar

  5. The initial 41Ca/40Ca ratios in two type A Ca-Al-rich inclusions: Implications for the origin of short-lived 41Ca

    Science.gov (United States)

    Liu, Ming-Chang

    2017-03-01

    This paper reports new 41Ca-41K isotopic data for two Type A CAIs, NWA 3118 #1Nb (Compact Type A) and Vigarano 3138 F8 (Fluffy Type A), from reduced CV3 chondrites. The NWA CAI is found to have carried live 41Ca at the level of (4.6 ± 1.9) ×10-9 , consistent with the proposed Solar System initial 41Ca /40Ca = 4.2 ×10-9 by Liu et al. (2012a). On the other hand, the Vigarano CAI does not have resolvable radiogenic 41K excesses that can be attributed to the decay of 41Ca. Combined with the 26Al data that have been reported for these two CAIs, we infer that the 41Ca distribution was not homogeneous when 26Al was widespread at the canonical level of 26Al /27Al = 5.2 ×10-5 . Such a 41Ca heterogeneity can be understood under two astrophysical contexts: in situ charged particle irradiation by the protoSun in the solar nebula that had inherited some baseline 10Be abundance from the molecular cloud, and Solar System formation in a molecular cloud enriched in 26Al and 41Ca contaminated by massive star winds. That said, more high quality 41Ca data are still needed to better understand the origin of this radionuclide.

  6. Genetically encoded green fluorescent Ca2+ indicators with improved detectability for neuronal Ca2+ signals.

    Science.gov (United States)

    Ohkura, Masamichi; Sasaki, Takuya; Sadakari, Junko; Gengyo-Ando, Keiko; Kagawa-Nagamura, Yuko; Kobayashi, Chiaki; Ikegaya, Yuji; Nakai, Junichi

    2012-01-01

    Imaging the activities of individual neurons with genetically encoded Ca(2+) indicators (GECIs) is a promising method for understanding neuronal network functions. Here, we report GECIs with improved neuronal Ca(2+) signal detectability, termed G-CaMP6 and G-CaMP8. Compared to a series of existing G-CaMPs, G-CaMP6 showed fairly high sensitivity and rapid kinetics, both of which are suitable properties for detecting subtle and fast neuronal activities. G-CaMP8 showed a greater signal (F(max)/F(min) = 38) than G-CaMP6 and demonstrated kinetics similar to those of G-CaMP6. Both GECIs could detect individual spikes from pyramidal neurons of cultured hippocampal slices or acute cortical slices with 100% detection rates, demonstrating their superior performance to existing GECIs. Because G-CaMP6 showed a higher sensitivity and brighter baseline fluorescence than G-CaMP8 in a cellular environment, we applied G-CaMP6 for Ca(2+) imaging of dendritic spines, the putative postsynaptic sites. By expressing a G-CaMP6-actin fusion protein for the spines in hippocampal CA3 pyramidal neurons and electrically stimulating the granule cells of the dentate gyrus, which innervate CA3 pyramidal neurons, we found that sub-threshold stimulation triggered small Ca(2+) responses in a limited number of spines with a low response rate in active spines, whereas supra-threshold stimulation triggered large fluorescence responses in virtually all of the spines with a 100% activity rate.

  7. Supralinear dendritic Ca(2+) signalling in young developing CA1 pyramidal cells.

    Science.gov (United States)

    Pohle, Jörg; Bischofberger, Josef

    2014-11-15

    Although Ca(2+) is critically important in activity-dependent neuronal development, not much is known about the regulation of dendritic Ca(2+) signals in developing neurons. Here, we used ratiometric Ca(2+) imaging to investigate dendritic Ca(2+) signalling in rat hippocampal pyramidal cells during the first 1-4 weeks of postnatal development. We show that active dendritic backpropagation of Nav channel-dependent action potentials (APs) evoked already large dendritic Ca(2+) transients in animals aged 1 week with amplitudes of ∼150 nm, similar to the amplitudes of ∼160 nM seen in animals aged 4 weeks. Although the AP-evoked dendritic Ca(2+) load increased about four times during the first 4 weeks, the peak amplitude of free Ca(2+) concentration was balanced by a four-fold increase in Ca(2+) buffer capacity κs (∼70 vs. ∼280). Furthermore, Ca(2+) extrusion rates increased with postnatal development, leading to a slower decay time course (∼0.2 s vs. ∼0.1 s) and more effective temporal summation of Ca(2+) signals in young cells. Most importantly, during prolonged theta-burst stimulation dendritic Ca(2+) signals were up to three times larger in cells at 1 week than at 4 weeks of age and much larger than predicted by linear summation, which is attributable to an activity-dependent slow-down of Ca(2+) extrusion. As Ca(2+) influx is four-fold smaller in young cells, the larger Ca(2+) signals are generated using four times less ATP consumption. Taken together, the data suggest that active backpropagations regulate dendritic Ca(2+) signals during early postnatal development. Remarkably, during prolonged AP firing, Ca(2+) signals are several times larger in young than in mature cells as a result of activity-dependent regulation of Ca(2+) extrusion rates.

  8. Neural Signals Related to Outcome Evaluation Are Stronger in CA1 than CA3.

    Science.gov (United States)

    Lee, Sung-Hyun; Huh, Namjung; Lee, Jong Won; Ghim, Jeong-Wook; Lee, Inah; Jung, Min W

    2017-01-01

    We have shown previously that CA1 conveys significant neural signals necessary to update value of the chosen target, namely chosen value and reward signals. To better understand hippocampal neural processes related to valuation, we compared chosen value- and reward-related neural activity between the CA3 and CA1 regions. Single units were recorded with tetrodes from the dorsal CA3 and CA1 regions of rats performing a dynamic foraging task, and chosen value- and reward-related neural activity was estimated using a reinforcement learning model and multiple regression analyses. Neural signals for chosen value and reward converged in both CA3 and CA1 when a trial outcome was revealed. However, these neural signals were stronger in CA1 than CA3. Consequently, neural signals for reward prediction error and updated chosen value were stronger in CA1 than CA3. Together with our previous finding that CA1 conveys stronger value signals than the subiculum, our results raise the possibility that CA1 might play a particularly important role among hippocampal subregions in evaluating experienced events.

  9. EMRE Is a Matrix Ca2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca2+ Uniporter

    Directory of Open Access Journals (Sweden)

    Horia Vais

    2016-01-01

    Full Text Available The mitochondrial uniporter (MCU is an ion channel that mediates Ca2+ uptake into the matrix to regulate metabolism, cell death, and cytoplasmic Ca2+ signaling. Matrix Ca2+ concentration is similar to that in cytoplasm, despite an enormous driving force for entry, but the mechanisms that prevent mitochondrial Ca2+ overload are unclear. Here, we show that MCU channel activity is governed by matrix Ca2+ concentration through EMRE. Deletion or charge neutralization of its matrix-localized acidic C terminus abolishes matrix Ca2+ inhibition of MCU Ca2+ currents, resulting in MCU channel activation, enhanced mitochondrial Ca2+ uptake, and constitutively elevated matrix Ca2+ concentration. EMRE-dependent regulation of MCU channel activity requires intermembrane space-localized MICU1, MICU2, and cytoplasmic Ca2+. Thus, mitochondria are protected from Ca2+ depletion and Ca2+ overload by a unique molecular complex that involves Ca2+ sensors on both sides of the inner mitochondrial membrane, coupled through EMRE.

  10. CaV1.1: The atypical prototypical voltage-gated Ca2+ channel

    Science.gov (United States)

    Bannister, Roger A.; Beam, Kurt G.

    2012-01-01

    CaV1.1 is the prototype for the other nine known CaV channel isoforms, yet it has functional properties that make it truly atypical of this group. Specifically, CaV1.1 is expressed solely in skeletal muscle where it serves multiple purposes; it is the voltage sensor for excitation-contraction (EC) coupling and it is an L-type Ca2+ channel which contributes to a form of activity-dependent Ca2+ entry that has been termed Excitation-Coupled Ca2+ Entry (ECCE). The ability of CaV1.1 to serve as voltage-sensor for EC coupling appears to be unique amongst CaV channels, whereas the physiological role of its more conventional function as a Ca2+ channel has been a matter of uncertainty for nearly 50 years. In this chapter, we discuss how CaV1.1 supports EC coupling, the possible relevance of Ca2+ entry through CaV1.1 and how alterations of CaV1.1 function can have pathophysiological consequences. PMID:22982493

  11. Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak

    Science.gov (United States)

    Sankaranarayanan, Rajiv; Li, Yatong; Greensmith, David J.; Eisner, David A.

    2016-01-01

    Key points Ca leak from the sarcoplasmic reticulum through the ryanodine receptor (RyR) reduces the amplitude of the Ca transient and slows its rate of decay.In the presence of β‐adrenergic stimulation, RyR‐mediated Ca leak produces a biphasic decay of the Ca transient with a fast early phase and a slow late phase.Two forms of Ca leak have been studied, Ca‐sensitising (induced by caffeine) and non‐sensitising (induced by ryanodine) and both induce biphasic decay of the Ca transient.Only Ca‐sensitising leak can be reversed by traditional RyR inhibitors such as tetracaine.Ca leak can also induce Ca waves. At low levels of leak, waves occur. As leak is increased, first biphasic decay and then slowed monophasic decay is seen. The level of leak has major effects on the shape of the Ca transient. Abstract In heart failure, a reduction in Ca transient amplitude and contractile dysfunction can by caused by Ca leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased activity of the SR Ca ATPase (SERCA). We have characterised the effects of two forms of Ca leak (Ca‐sensitising and non‐sensitising) on calcium cycling and compared with those of SERCA inhibition. We measured [Ca2+]i with fluo‐3 in voltage‐clamped rat ventricular myocytes. Increasing SR leak with either caffeine (to sensitise the RyR to Ca activation) or ryanodine (non‐sensitising) had similar effects to SERCA inhibition: decreased systolic [Ca2+]i, increased diastolic [Ca2+]i and slowed decay. However, in the presence of isoproterenol, leak produced a biphasic decay of the Ca transient in the majority of cells while SERCA inhibition produced monophasic decay. Tetracaine reversed the effects of caffeine but not of ryanodine. When caffeine (1 mmol l−1) was added to a cell which displayed Ca waves, the wave frequency initially increased before waves disappeared and biphasic decay developed. Eventually (at higher caffeine concentrations), the

  12. The climate protection policy of the USA under president Obama; Die Klimaschutzpolitik der USA unter Praesident Obama

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Wolfgang; Schenk, Olga [Forschungszentrum Juelich (Germany). Inst. fuer Energieforschung - Systemforschung und Technologische Entwicklung; Holtrup-Mostert, Petra [Transatlantic Networks - Foreign Policy Analysis, Koenigswinter (Germany)

    2009-01-15

    Barack Obama's slogan 'Are you ready for a Change?' may become the motto fo the future climate protection policy of the USA. While the USA is slowly beginning to play a more active role in this area, there are many political and institutional obstacles to overcome before the USA can become one of the big global players here. The authors analyse the status quo of the US climate protection policy in an attempt to indicate national and international perspectives of climate protection. (orig.)

  13. A BWR licensing experience in the USA

    Energy Technology Data Exchange (ETDEWEB)

    Powers, J.; Ogura, C. [Toshiba America Nuclear Energy, Charlotte, North Carolina (United States); Arai, K. [Toshiba Corporation, Yokohama, Kanagawa (Japan); Thomas, S.; Mookhoek, B., E-mail: jim.powers@toshiba.com [Nuclear Innovation North America, Lake Jackson, Texas (United States)

    2015-09-15

    The US-Advanced Boiling Water Reactor (A BWR), certified by the United States Nuclear Regulatory Commission (US NRC), is a third generation, evolutionary boiling water reactor design which is the reference for the South Texas Project Units 3 and 4 (STP3-4) Combined License Application (Cola). Nuclear Innovation North America (Nina) is the License Applicant for this new build project, and Toshiba is the selected primary technology contractor. The STP3-4 project has finished the US NRC technical review of the Cola through the final meeting of the Advisory Committee on Reactor Safeguards (ACRS), and the Final Safety Evaluation Report (FSER) is scheduled to be issued by the US NRC in the middle of 2015. The next steps are to support the Mandatory Hearing process, and voting by the NRC commissioners on the motion to grant the Combined License, which is scheduled beginning of 2016 according to US NRC schedule as of March 30, 2015. This paper summarizes the history and progress of the US-A BWR licensing, including the experiences of the Licensee, Nina, and Toshiba as the Epc team worked through the Code of Federal Regulations Title 10 (10-Cfr) Part 52 process, and provides some perspectives on how the related licensing material would also be of value within a 10-Cfr Part 50, two-step process to minimize schedule and financial risks which could arise from ongoing technical developments and regulatory reviews. (Author)

  14. Professional Training of Economists in the USA

    Directory of Open Access Journals (Sweden)

    Rudnitska Kateryna

    2014-12-01

    Full Text Available The article deals with the peculiarities of American professional undergraduate and graduate training in economics. The analysis of documents, scientific and educational literature demonstrates the diversity of the US training courses and combinations of disciplines in economics. It has been defined that leading position of the USA in the world and its impact on the economic life of other countries has predetermined the development of the internationalization of economic education at the undergraduate and graduate level: by offering courses in International Economics as well as introductory programs for international Internships for students and teachers. The program of study in economics provides various forms of learning, number of major, minor and elective courses. It has been determined that economics majors include variety of courses, ranging from those which are intensely mathematical like Principles of Economics, Microeconomic, Macroeconomics and Econometrics, to more philosophical courses like History of Economic Thought. Moreover, courses in Survey Design, Political Science and Computer Science are also highly recommended and essential for future success. In order to achieve the objectives in economists' training in high school a system of new methods, means and approaches (“Chalk and Talk”, “Proficiency Approach”, “Peaconomics”, “Writing Intensive” are used to stimulate and motivate students to cognitive functions. The educational process and control by teachers through traditional and innovative techniques provides effective feedback.

  15. Proteasome alteration and delayed neuronal death in hippocampal CA1 and dentate gyrus regions following transient cerebral ischemia

    Institute of Scientific and Technical Information of China (English)

    Pengfei Ge; Tianfei Luo; Jizhou Zhang; Haifeng Wang; Wenchen Li; Yongxin Luan; Feng Ling; Yi'nan Luo

    2009-01-01

    BACKGROUND:Proteasome dysfunction has been reported to induce abnormal protein aggregation and cell death.OBJECTIVE:To investigate the effect of proteasome changes on delayed neuronal death in CA1 and dentate gyrus (DG) regions of the rat hippocampus following transient cerebral ischemia.DESIGN,TIME AND SETTING:A randomized,controlled animal experiment.The study was performed at the Department of Biochemistry and Molecular Biology,Norman Bethune Medical College of Jilin University,from September 2006 to May 2008.MATERIALS:Rabbit anti-19S S10B polyclonal antibody was purchased from Bioreagents,USA;propidium iodide and fluorescently-labeled goat anti-rabbit IgG were purchased from Jackson Immunoresearch,USA;hematoxylin and eosin staining solution was purchased from Sigma,USA;LSM 510 confocal microscope was purchased from Zeiss,Germany.METHODS:A total of 40 healthy Wistar rats,male,4 months old,were randomly divided into sham surgery group (n=8) and model group (n=32).Ischemic models were established in the model group by transient clamping of the bilateral carotid arteries and decreased blood pressure.After 20 minutes of global ischemia,the clamp was removed to allow blood flow for 30 minutes,4,24,and 72 hours,respectively,with 8 rats at each time point.The bilateral carotid arteries were not ligated in the sham surgery group.MAIN OUTCOME MEASURES:Neuronal death in the CA1 and DG regions was observed by hematoxylin-eosin staining.Proteasome expression in CA1 and DG region neurons was detected by immunohistochemistry.RESULTS:Hematoxylin-eosin staining showed neuronal death in the CA1 region alone at 72 hours of reperfusion following ischemia.In comparison to the sham surgery group,a significant decrease in proteasome expression was observed,by immunohistochemistry,in the CA1 and DG regions in the model group,following 30 minutes,4,24,and 72 hours of reperfusion (P<0.01).After 72 hours of reperfusion following ischemia,proteasome expression had almost completely

  16. 2015 Gridded bathymetry of Reef Runway, Oahu Hawaii, USA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Gridded bathymetry (1m) of Reef Runway ship grounding site, Oahu, Hawaii, USA. The data include multibeam bathymetry from the Reson 8101 multibeam sonar collected in...

  17. USA valitsus sõdib New Yorgi suurlehega / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2006-01-01

    New York Timesi tembeldamine USA ebapatriootlikemaks ajaleheks, sest see uuris Bushi administratsiooni salajasi jälgimisprogramme, on tekitanud küsimuse, kas tegu pole poliitilise aktsiooniga õõnestada lehe usaldusväärsust

  18. Ämari baas sobib USA-le ja brittidele

    Index Scriptorium Estoniae

    2013-01-01

    Eelmisel nädalal Eestit külastanud USA ja Ühendkuningriigi sõjalised esindajad NATO juures kindralleitnandid David R. Hogg ja Christopher Harper kinnitasid, et on valmis oma lennukeid Ämari baasist opereerima

  19. USA andis Venemaale vastulöögi / Argo Ideon

    Index Scriptorium Estoniae

    Ideon, Argo, 1966-

    2011-01-01

    USA välisministeerium teatas, et ühendriigid peatavad teatud kohustuste täitmise Venemaa suhtes Euroopa tavarelvade leppe (CFE) raames, sest Venemaa ei ole viimase nelja aasta jooksul lepet täitnud. Euroopa tavarelvade lepe

  20. Biochar in the USA. Starting new methods for green energy

    Energy Technology Data Exchange (ETDEWEB)

    Meehan, Chris

    2012-07-01

    Companies in the USA develop pyrolysis and gasification systems to generate electricity from biomass and sell the by-product. Up to now it is interesting for agriculture and livestock producers. (orig.)

  1. Reson 8101 Backscatter imagery of Penguin Bank, Molokai, Hawaii, USA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Backscatter imagery extracted from gridded bathymetry of Penguin Bank, Molokai, Hawaii, USA. These data provide almost complete coverage between 0 and 100 meters....

  2. Origin and Development of Multicultural Education in the USA

    National Research Council Canada - National Science Library

    Leila Sultanova

    2016-01-01

    .... Multicultural education is quite a new branch of pedagogical theory and practice. Its appearance is considered to be connected with a period of complex social and cultural transformations in the USA during 1960s-1970s. However, J...

  3. Gridded bathymetry of Kohala, Hawaii, Main Hawaiian Islands, USA.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — 5-m grid of bathymetric data of Kohala coast of Hawaii, Main Hawaiian Islands, USA. The ASCII grids include multibeam bathymetry from the Reson 8101 multibeam sonar...

  4. CIA salalennud varjutasid USA-Saksa kohtumist / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2005-01-01

    Saksa välisministri Frank-Walter Steinmeieri visiidist Washingtoni. Vahetult enne välisministri visiiti selgus, et USA Luure Keskagentuuri salalennukid terrorismisõjas vahistatutega võisid maanduda ka Saksamaal

  5. Ocean Biogeographic Information System (OBIS) - USA Dataset Collection

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — OBIS-USA provides aggregated, interoperable biogeographic data collected primarily from U.S. waters and oceanic regions--the Arctic, the Atlantic and Pacific oceans,...

  6. Eesti ja USA kaitsekoostöö saab uue aluspaberi

    Index Scriptorium Estoniae

    2017-01-01

    Valitsus kiitis eilsel istungil heaks Eesti ja Ameerika Ühendriikide valitsuse kaitsekoostöö kokkuleppe ning volitas kaitseminister Margus Tsahknat allkirjastama selle USA suursaadikuga Eestis. Leppe peab ratifitseerima ka riigikogu

  7. Wikileaks Soomes: USA huvitus Venest ja iseloomustas poliitikuid / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2011-01-01

    Ajalehes Helsingin Sanomat avaldatud ülevaadetest USA diplomaatide memodest, mis lekkisid Wikileaksi kaudu ja mis puudutavad Soome välispoliitikat, kokkupuuteid Venemaaga, hinnanguid Soome tipp-poliiitikutele

  8. News and Features Updates from USA.gov

    Data.gov (United States)

    General Services Administration — Stay on top of important government news and information with the USA.gov Updates: News and Features RSS feed. We'll update this feed when we add news and featured...

  9. USA kuulas pealt Chiraci kõnesid / Riina Tallo

    Index Scriptorium Estoniae

    Tallo, Riina

    2004-01-01

    Prantsusmaal ilmuva Henri Vernet' ja Thomas Cantaloube'i raamatu väitel kuulas USA Iraagi kriisi kulmineerudes regulaarselt pealt Prantsusmaa presidendi Jacques Chiraci ja tema kaastöötajate telefonikõnesid Elysee' lossis.

  10. Ocean Biogeographic Information System (OBIS) - USA Dataset Collection

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — OBIS-USA provides aggregated, interoperable biogeographic data collected primarily from U.S. waters and oceanic regions--the Arctic, the Atlantic and Pacific...

  11. USA politsei valusad küsimused / Eve Tisler

    Index Scriptorium Estoniae

    Tisler, Eve

    2015-01-01

    Ameerika Ühendriikide õiguskaitseorganite viimase aja suurimad probleemid on seotud süüdistustega, et USA politsei kasutab oma töös liigset jõudu ja teeb seda eelkõige mustanahaliste inimestega suheldes

  12. USA paisutas mullu maailma sõjalisi kulutusi

    Index Scriptorium Estoniae

    2007-01-01

    Stockholmi rahvusvahelise rahu-uuringute instituudi (SIPRI) raporti kohaselt on kasvasid riikide kulutused relvajõududele aastaga 3,5%, viimase 10 aastaga 37%. USA relvajõududele kulus 396 miljardit

  13. Film teeb USA valmistumise Iraagi okupatsiooniks maatasa / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    Dokumentaalfilm "Lõppu ei ole näha" ("No End in Sight") : autor ja režissöör professor Charles Ferguson : Ameerika Ühendriigid 2007. Lisa: USA vead Iraagis. Vt. samas: Sunniidid lahkusid Iraagi valitsusest

  14. USA ärgitab Saddami eksiili saatma / Sten A Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Sten A., 1979-

    2003-01-01

    USA kaitseminister Donald Rumsfeld, välisminister Colin Powell ja riikliku julgeoleku nõunik Condoleezza Rice toetavad ideed saata Iraagi president Saddam Hussein eksiili. Iraagi erisaadik lükkas selle võimaluse tagasi

  15. Ämari baas sobib USA-le ja brittidele

    Index Scriptorium Estoniae

    2013-01-01

    Eelmisel nädalal Eestit külastanud USA ja Ühendkuningriigi sõjalised esindajad NATO juures kindralleitnandid David R. Hogg ja Christopher Harper kinnitasid, et on valmis oma lennukeid Ämari baasist opereerima

  16. Film teeb USA valmistumise Iraagi okupatsiooniks maatasa / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    Dokumentaalfilm "Lõppu ei ole näha" ("No End in Sight") : autor ja režissöör professor Charles Ferguson : Ameerika Ühendriigid 2007. Lisa: USA vead Iraagis. Vt. samas: Sunniidid lahkusid Iraagi valitsusest

  17. Terroriekspert kujutab USA valitsust fanaatilise grupina / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2004-01-01

    USA terroriekspert Richard Clarke maalib oma mälestustekogus "Against All Enemies" Bushi administratsioonist pildi kui kohe ametisse astumise järel fanaatiliselt Iraagi-vastaseid samme sepitsema hakanud grupist. Lisa: Neli presidenti terrori-raamatus

  18. USA andis Venemaale vastulöögi / Argo Ideon

    Index Scriptorium Estoniae

    Ideon, Argo, 1966-

    2011-01-01

    USA välisministeerium teatas, et ühendriigid peatavad teatud kohustuste täitmise Venemaa suhtes Euroopa tavarelvade leppe (CFE) raames, sest Venemaa ei ole viimase nelja aasta jooksul lepet täitnud. Euroopa tavarelvade lepe

  19. Gridded bathymetry of Barbers Point, Oahu Hawaii, USA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Gridded bathymetry (1m) of Barbers Point ship grounding site, Oahu, Hawaii, USA. The data include multibeam bathymetry from the Reson 8101 multibeam sonar collected...

  20. USA Kongressi raport kritiseerib orkaan Katrinale reageerimist / Kaarel Kaas

    Index Scriptorium Estoniae

    Kaas, Kaarel, 1978-

    2006-01-01

    Ilmunud ka: Postimees : na russkom jazõke 14. veebr. lk. 7. USA Kongressi raport kritiseerib kõikide võimutasandite tegutsemist orkaan Katrina põhjustatud katastroofi ajal. Lisa: Kõigi läbikukkumine

  1. USA ärgitab Saddami eksiili saatma / Sten A Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Sten A., 1979-

    2003-01-01

    USA kaitseminister Donald Rumsfeld, välisminister Colin Powell ja riikliku julgeoleku nõunik Condoleezza Rice toetavad ideed saata Iraagi president Saddam Hussein eksiili. Iraagi erisaadik lükkas selle võimaluse tagasi

  2. Eesti ja USA kaitsekoostöö saab uue aluspaberi

    Index Scriptorium Estoniae

    2017-01-01

    Valitsus kiitis eilsel istungil heaks Eesti ja Ameerika Ühendriikide valitsuse kaitsekoostöö kokkuleppe ning volitas kaitseminister Margus Tsahknat allkirjastama selle USA suursaadikuga Eestis. Leppe peab ratifitseerima ka riigikogu

  3. Optically stimulated luminescence age controls on late Pleistocene and Holocene coastal lithosomes, North Carolina, USA

    Science.gov (United States)

    Mallinson, D.; Burdette, K.; Mahan, S.; Brook, G.

    2008-01-01

    Luminescence ages from a variety of coastal features on the North Carolina Coastal Plain provide age control for shoreline formation and relative sea-level position during the late Pleistocene. A series of paleoshoreline ridges, dating to Marine Isotope Stage (MIS) 5a and MIS 3 have been defined. The Kitty Hawk beach ridges, on the modern Outer Banks, yield ages of 3 to 2??ka. Oxygen-isotope data are used to place these deposits in the context of global climate and sea-level change. The occurrence of MIS 5a and MIS 3 shorelines suggests that glacio-isostatic adjustment (GIA) of the study area is large (ca. 22 to 26??m), as suggested and modeled by other workers, and/or MIS 3 sea level was briefly higher than suggested by some coral reef studies. Correcting the shoreline elevations for GIA brings their elevation in line with other sea-level indicators. The age of the Kitty Hawk beach ridges places the Holocene shoreline well west of its present location at ca. 3 to 2??ka. The age of shoreline progradation is consistent with the ages of other beach ridge complexes in the southeast USA, suggesting some regionally contemporaneous forcing mechanism. ?? 2007 University of Washington.

  4. Growth and nutrition of baldcypress families planted under varying salinity regimes in Louisiana, USA

    Science.gov (United States)

    Krauss, K.W.; Chambers, J.L.; Allen, J.A.; Soileau, D.M.; DeBosier, A.S.

    2000-01-01

    Saltwater intrusion from the Gulf of Mexico is one important factor in the destruction of baldcypress (Taxodium distichum (L.) Rich.) swamps along the Louisiana Gulf Coast, USA. Recent restoration efforts have focused on identification of baldcypress genotypes with greater tolerance to saline conditions than previously reported. To date, salt tolerance investigations have not been conducted under saline field conditions. In 1996, therefore, three plantations were established with 10 half-sib genotype collections of baldcypress in mesohaline wetlands. Tree survival and growth were measured at the end of two growing seasons, and foliar ion concentrations of Na, Cl, K, and Ca and available soil nutrients were measured during the 1996 growing season. In general, soil nutrient concentrations exceeded averages found in other baldcypress stands in the southeastern United States. Seedlings differed among sites in all parameters measured, with height, diameter, foliar biomass, and survival decreasing as site salinity increased. Average seedling height at the end of two years, for example, was 196.4 cm on the lowest salinity site and 121.6 cm on the highest. Several half-sib families maintained greater height growth increments (ranging from 25.5 to 54.5 cm on the highest salinity site), as well as lower foliar ion concentrations of K, Cl, and Ca. Results indicate that genotypic screening of baldcypress may improve growth and vigor of seedlings planted within wetlands impacted by saltwater intrusion.

  5. USA salajane riigiametnike komisjon võib panna ka oma kodanikud tapanimekirja / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2011-01-01

    Jeemenis USA droonirünnakus hukkunud Anwar al-Awlaki, keda USA valitsusesindajad nimetasid al-Qaida talendiotsijaks ja värvatute motiveerijaks, oli väidetavalt esimene USA kodanik, kes oli pandud USA vastu võitlevate terroristide nn. tapanimekirja

  6. Iraagis on surma saanud juba 2000 USA sõjaväelast / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2005-01-01

    USA-s suri 2000. sõjaväelane Iraagis saadud haavadesse. Kui USA juhitud välismaiste relvajõudude esindaja Bagdadis kutsus meediat seda arvu mitte üle tähtsustama, siis USA meedia seevastu pidas seda just oluliseks märgiks. Diagrammid: Iraagi sõja inimkaotused

  7. USA kindral ei soovita sõjalist kohalolekut Iraagis niipea vähendada / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2007-01-01

    USA vägede juhataja Iraagis David Petraeus ja suursaadik Iraagis Ryan Cocker käsitlesid USA Esindajatekoja relvajõudude ja väliskomitee ühisistungil olukorda Iraagis ja USA sõjalist kohalolekut. Nad soovisid Kongressilt USA vägede säilitamist enam-vähem praegusel tasemel kuni 2008. aasta suveni

  8. Clinton: USA kaotab infosõjas Hiina, Venemaa ja Al Jazeeraga / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2011-01-01

    USA välisministri Hillary Clintoni hinnangul on USA propaganda nõrgenenud ning USA mõjuvõim väheneb pidevalt. H. Clintoni vastusest Senati väliskomisjonis senaator Richard Lugari küsimusele USA pingutustest diplomaatilise kommunikatsiooni vallas

  9. Clinton: USA kaotab infosõjas Hiina, Venemaa ja Al Jazeeraga / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2011-01-01

    USA välisministri Hillary Clintoni hinnangul on USA propaganda nõrgenenud ning USA mõjuvõim väheneb pidevalt. H. Clintoni vastusest Senati väliskomisjonis senaator Richard Lugari küsimusele USA pingutustest diplomaatilise kommunikatsiooni vallas

  10. USA kindral ei soovita sõjalist kohalolekut Iraagis niipea vähendada / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2007-01-01

    USA vägede juhataja Iraagis David Petraeus ja suursaadik Iraagis Ryan Cocker käsitlesid USA Esindajatekoja relvajõudude ja väliskomitee ühisistungil olukorda Iraagis ja USA sõjalist kohalolekut. Nad soovisid Kongressilt USA vägede säilitamist enam-vähem praegusel tasemel kuni 2008. aasta suveni

  11. USA salajane riigiametnike komisjon võib panna ka oma kodanikud tapanimekirja / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2011-01-01

    Jeemenis USA droonirünnakus hukkunud Anwar al-Awlaki, keda USA valitsusesindajad nimetasid al-Qaida talendiotsijaks ja värvatute motiveerijaks, oli väidetavalt esimene USA kodanik, kes oli pandud USA vastu võitlevate terroristide nn. tapanimekirja

  12. USA järelevalve e-side üle maailmas tugevneb / Tõnis Arnover

    Index Scriptorium Estoniae

    Arnover, Tõnis, 1952-

    2007-01-01

    USA Kongress võttis vastu seaduse, mis annab eriteenistustele suurema tegutsemisvabaduse rahvusvahelise e-side jälgimisel ning nõuab USA-d külastavate viisavabade riikide ärimeestelt eelinfot oma tegevuse kohta. Lisa: USA-s heakskiidetud terrorismivastased abinõud

  13. 78 FR 14400 - Southern USA Resources, Inc., Order of Suspension of Trading

    Science.gov (United States)

    2013-03-05

    ... COMMISSION Southern USA Resources, Inc., Order of Suspension of Trading March 1, 2013. It appears to the... securities of Southern USA Resources, Inc. (``Southern USA'') because of questions regarding the accuracy of... company's outstanding shares. Southern USA's securities are quoted on the OTC Link, operated by...

  14. Pesticides et toxicité chez l'abeille - USA

    OpenAIRE

    Johnson, Reed M.; Marion D Ellis; Mullin, Christopher A.; Frazier, Maryann

    2010-01-01

    International audience; Until 1985 discussions of pesticides and honey bee toxicity in the USA were focused on pesticides applied to crops and the unintentional exposure of foraging bees to them. The recent introduction of arthropod pests of honey bees, Acarapis woodi (1984), Varroa destructor (1987), and Aethina tumida (1997), to the USA have resulted in the intentional introduction of pesticides into beehives to suppress these pests. Both the unintentional and the intentional exposure of ho...

  15. Carbon storage and sequestration by urban trees in the USA

    Science.gov (United States)

    David J. Nowak; Daniel E. Crane

    2002-01-01

    Based on field data from 10 USA cities and national urban tree cover data, it is estimated that urban trees in the coterminous USA currently store 700 million tonnes of carbon ($14,300 million value) with a gross carbon sequestration rate of 22.8 million tC/yr ($460 rnillion/year). Carbon storage within cities ranges From 1.2 million tC in New York, NY, to 19,300 tC in...

  16. Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels.

    Science.gov (United States)

    Oliveria, Seth F; Dittmer, Philip J; Youn, Dong-ho; Dell'Acqua, Mark L; Sather, William A

    2012-10-31

    Excitation-driven entry of Ca(2+) through L-type voltage-gated Ca(2+) channels controls gene expression in neurons and a variety of fundamental activities in other kinds of excitable cells. The probability of opening of Ca(V)1.2 L-type channels is subject to pronounced enhancement by cAMP-dependent protein kinase (PKA), which is scaffolded to Ca(V)1.2 channels by A-kinase anchoring proteins (AKAPs). Ca(V)1.2 channels also undergo negative autoregulation via Ca(2+)-dependent inactivation (CDI), which strongly limits Ca(2+) entry. An abundance of evidence indicates that CDI relies upon binding of Ca(2+)/calmodulin (CaM) to an isoleucine-glutamine motif in the carboxy tail of Ca(V)1.2 L-type channels, a molecular mechanism seemingly unrelated to phosphorylation-mediated channel enhancement. But our work reveals, in cultured hippocampal neurons and a heterologous expression system, that the Ca(2+)/CaM-activated phosphatase calcineurin (CaN) is scaffolded to Ca(V)1.2 channels by the neuronal anchoring protein AKAP79/150, and that overexpression of an AKAP79/150 mutant incapable of binding CaN (ΔPIX; CaN-binding PXIXIT motif deleted) impedes CDI. Interventions that suppress CaN activity-mutation in its catalytic site, antagonism with cyclosporine A or FK506, or intracellular perfusion with a peptide mimicking the sequence of the phosphatase's autoinhibitory domain-interfere with normal CDI. In cultured hippocampal neurons from a ΔPIX knock-in mouse, CDI is absent. Results of experiments with the adenylyl cyclase stimulator forskolin and with the PKA inhibitor PKI suggest that Ca(2+)/CaM-activated CaN promotes CDI by reversing channel enhancement effectuated by kinases such as PKA. Hence, our investigation of AKAP79/150-anchored CaN reconciles the CaM-based model of CDI with an earlier, seemingly contradictory model based on dephosphorylation signaling.

  17. Isolation and characterization of higher metallofullerenes Ca@C92 and Ca@C94

    Indian Academy of Sciences (India)

    Yuliang Che; Hua Yang; Hongxiao Jin; Chunxin Lu; Ziyang Liu

    2009-05-01

    We report for the first time isolation of Ca@C92 and Ca@C94 by multi-stage highperformance liquid chromatography technique without recycling equipment. It is notable that higher metallofullerenes containing alkaline earth metal ions could be isolated although their relative yields are extremely low. Ca@C92 and Ca@C94 are also confirmed by LD-TOF mass spectrometry and characterrized by UV-Vis-NIR absorption measurements.

  18. Influence of Panax quinquefolium saponins on increased intracellular Ca2+ in PC12 cells

    Institute of Scientific and Technical Information of China (English)

    Lixin Guan; Xiudong Jin; Yanhui Chu; Yufei Zhang; Yan Wu; Xin Yi; Fengguo Zhai; Mengquan Li

    2009-01-01

    BACKGROUND: Previous studies have demonstrated that intracellular Ca2+ ([Ca2+]i) overload,excitotoxicity, free radical injury, and nitric oxide toxicity are involved in mechanisms of neuronal death in the ischemic brain.OBJECTIVE: To investigate the influence of Panax quinquefolium saponins (PQS) on multiple factors-induced Ca2+ overload in the rat pheochromocytoma (PC12) cell line.DESIGN, TIME AND SETTING: Intergroup comparison, in vitro study. The experiment was performed at the Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy, Mudanjiang Medical University between November 2007 and April 2008.MATERIALS: In vitro cultured PC12 cells in the logarithmic phase were assigned into blank control, model, and drug treatment groups (10 μmol/L nimodipine; 40 μg/L, 100 μg/L, and 250 μg/L PQS). Nimodipine was purchased from Jiangsu Yangtze River Pharmacy Group Co.,China; PQS (purity > 95%, HLPC grade) was provided by School of Basic Medical Sciences, Jilin University. Caffeine, Na2S204, L-glutamic acid (Glu), Fura-2/AM, and calcium ionophore A23187 were purchased from Sigma, USA.METHODS: PC12 cells in the model and drug treatment groups were separately incubated in glucose-free Hank's buffered saline solution + Na2S2O4, (2 mmol/L) for 6 hours, Glu (200 μ mol/L)plus A23187 (0.05 μmol/L) for 6 hours, KCI (50 mmol/L) for 1 hour, and caffeine (5 mmol/L) for 3 hours to establish models of intracellular Ca2+ overload induced by oxygen and glucose deprivation, Glu, A23187, high K+, or caffeine. In addition, control cells were incubated in high-glucose DMEM culture medium.MAIN OUTCOME MEASURES: [Ca2+]i changes in PC12 cells exposed to oxygen-glucose deprivation, Glu, A23187, high K+, or caffeine were detected using spectrofluorometer.RESULTS: PQS blocked the [Ca2+]i increase induced by oxygen-glucose deprivation, Glu,A23187, high K+, or caffeine. In particular, high-dose PQS was most effective (P < 0.01). PQS significantly inhibited Glu- or caffeine-induced [Ca2+]i

  19. Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression.

    Science.gov (United States)

    Wheeler, Damian G; Groth, Rachel D; Ma, Huan; Barrett, Curtis F; Owen, Scott F; Safa, Parsa; Tsien, Richard W

    2012-05-25

    Activity-dependent gene expression triggered by Ca(2+) entry into neurons is critical for learning and memory, but whether specific sources of Ca(2+) act distinctly or merely supply Ca(2+) to a common pool remains uncertain. Here, we report that both signaling modes coexist and pertain to Ca(V)1 and Ca(V)2 channels, respectively, coupling membrane depolarization to CREB phosphorylation and gene expression. Ca(V)1 channels are advantaged in their voltage-dependent gating and use nanodomain Ca(2+) to drive local CaMKII aggregation and trigger communication with the nucleus. In contrast, Ca(V)2 channels must elevate [Ca(2+)](i) microns away and promote CaMKII aggregation at Ca(V)1 channels. Consequently, Ca(V)2 channels are ~10-fold less effective in signaling to the nucleus than are Ca(V)1 channels for the same bulk [Ca(2+)](i) increase. Furthermore, Ca(V)2-mediated Ca(2+) rises are preferentially curbed by uptake into the endoplasmic reticulum and mitochondria. This source-biased buffering limits the spatial spread of Ca(2+), further attenuating Ca(V)2-mediated gene expression.

  20. USA Is Concerned to the Oil of Middle East

    Energy Technology Data Exchange (ETDEWEB)

    Hong, S.M. [Korea Institute of the Mideast Economies, Seoul (Korea)

    2002-02-01

    USA has increased its power on the international oil market since Gulf War. As USA secures the hegemony in Middle East region, USA has helped the return of Majors, which had been lost after 1970s, and Saudi Arabia, the biggest oil producing country, positively follows USA. A new change of the international oil market has been actualized by forming a long-term alliance between USA and Saudi Arabia, a major component of the change, and it is characterized by a kind of geopolitical substance. After 30 years since the ruling power of US oil companies in the international oil market was damaged and actually removed, finally, the ruling axis of the international oil market is to completely return to the original position. The hegemony of USA has been reconfirmed. In the powerful politics and the economical cooperation for the interests related to the international oil, the basic intervene of Saudi Arabia will be proved as thee most powerful force among the effective and long-term systems, which they established in the past.

  1. Incremental Aerodynamic Coefficient Database for the USA2

    Science.gov (United States)

    Richardson, Annie Catherine

    2016-01-01

    In March through May of 2016, a wind tunnel test was conducted by the Aerosciences Branch (EV33) to visually study the unsteady aerodynamic behavior over multiple transition geometries for the Universal Stage Adapter 2 (USA2) in the MSFC Aerodynamic Research Facility's Trisonic Wind Tunnel (TWT). The purpose of the test was to make a qualitative comparison of the transonic flow field in order to provide a recommended minimum transition radius for manufacturing. Additionally, 6 Degree of Freedom force and moment data for each configuration tested was acquired in order to determine the geometric effects on the longitudinal aerodynamic coefficients (Normal Force, Axial Force, and Pitching Moment). In order to make a quantitative comparison of the aerodynamic effects of the USA2 transition geometry, the aerodynamic coefficient data collected during the test was parsed and incorporated into a database for each USA2 configuration tested. An incremental aerodynamic coefficient database was then developed using the generated databases for each USA2 geometry as a function of Mach number and angle of attack. The final USA2 coefficient increments will be applied to the aerodynamic coefficients of the baseline geometry to adjust the Space Launch System (SLS) integrated launch vehicle force and moment database based on the transition geometry of the USA2.

  2. Ca(2+) signalling in the Golgi apparatus.

    Science.gov (United States)

    Pizzo, Paola; Lissandron, Valentina; Capitanio, Paola; Pozzan, Tullio

    2011-08-01

    The Golgi apparatus plays a central role in lipid and protein post-translational modification and sorting. Morphologically the organelle is heterogeneous and it is possible to distinguish stacks of flat cysternae (cis- and medial Golgi), tubular-reticular networks and vesicles (trans-Golgi). These morphological differences parallel a distinct functionality with a selective distribution and complementary roles of the enzymes found in the different compartments. The Golgi apparatus has been also shown to be involved in Ca(2+) signalling: it is indeed endowed with Ca(2+) pumps, Ca(2+) release channels and Ca(2+) binding proteins and is thought to participate in determining the spatio-temporal complexity of the Ca(2+) signal within the cell, though this role is still poorly understood. Recently, it has been demonstrated that the organelle is heterogeneous in terms of Ca(2+) handling and selective reduction of Ca(2+) concentration, both in vitro and in a genetic human disease, within one of its sub-compartment results in alterations of protein trafficking within the secretory pathway and of the entire Golgi morphology. In this paper we review the available information on the Ca(2+) toolkit within the Golgi, its heterogeneous distribution in the organelle sub-compartments and discuss the implications of these characteristics for the physiopathology of the Golgi apparatus.

  3. LATS refining ladle slag modifying with CaO-CaF2

    Institute of Scientific and Technical Information of China (English)

    Hongming Wang; Guirong Li; Zhongming Ren; Bo Li; Xuejun Zhang; Guomin Shi

    2007-01-01

    To reduce the slag sticking onto the snorkel of the ladle during the ladle alloying treatment station (LATS) process, CaO-CaF2 (the mass ratio of CaO/CaF2 is 1:1) was employed as the modifier of the LATS refining ladle slag. The effect of CaO-CaF2 on the melting point, viscosity, and desulfurizing capability of the ladle slag was investigated. The melting point of the unmodified ladle slag is 1439°C. When adding 20wt% CaO-CaF2, the melting point is decreased to 1327°C. At 1500°C, the viscosity of the unmodified ladle slag is 6.5 Pa·s, which can be decreased lower than 2 Pa·s by adding more than 10wt% CaO-CaF2. The experimental results of desulfurization of the melts show that the desulfurizing power of the ladle slag can be enhanced by adding CaO-CaF2.

  4. By Regulating Mitochondrial Ca2+-Uptake UCP2 Modulates Intracellular Ca2+.

    Directory of Open Access Journals (Sweden)

    Lukas Jaroslaw Motloch

    Full Text Available The possible role of UCP2 in modulating mitochondrial Ca2+-uptake (mCa2+-uptake via the mitochondrial calcium uniporter (MCU is highly controversial.Thus, we analyzed mCa2+-uptake in isolated cardiac mitochondria, MCU single-channel activity in cardiac mitoplasts, dual Ca2+-transients from mitochondrial ((Ca2+m and intracellular compartment ((Ca2+c in the whole-cell configuration in cardiomyocytes of wild-type (WT and UCP2-/- mice.Isolated mitochondria showed a Ru360 sensitive mCa2+-uptake, which was significantly decreased in UCP2-/- (229.4±30.8 FU vs. 146.3±23.4 FU, P0.05 and transsarcolemmal Ca2+-influx was inhibited suggesting a possible compensatory mechanism. Additionally, we observed an inhibitory effect of ATP on mCa2+-uptake in WT mitoplasts and (Ca2+m of cardiomyocytes leading to an increase of (Ca2+c while no ATP dependent effect was observed in UCP2-/-.Our results indicate regulatory effects of UCP2 on mCa2+-uptake. Furthermore, we propose, that previously described inhibitory effects on MCU by ATP may be mediated via UCP2 resulting in changes of excitation contraction coupling.

  5. Ca-Dependent Folding of Human Calumenin

    Science.gov (United States)

    Mazzorana, Marco; Hussain, Rohanah; Sorensen, Thomas

    2016-01-01

    Human calumenin (hCALU) is a six EF-hand protein belonging to the CREC family. As other members of the family, it is localized in the secretory pathway and regulates the activity of SERCA2a and of the ryanodine receptor in the endoplasmic reticulum (ER). We have studied the effects of Ca2+ binding to the protein and found it to attain a more compact structure upon ion binding. Circular Dichroism (CD) measurements suggest a major rearrangement of the protein secondary structure, which reversibly switches from disordered at low Ca2+ concentrations to predominantly alpha-helical when Ca2+ is added. SAXS experiments confirm the transition from an unfolded to a compact structure, which matches the structural prediction of a trilobal fold. Overall our experiments suggest that calumenin is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range. PMID:26991433

  6. Incorporating Resource Protection Constraints in an Analysis of Landscape Fuel-Treatment Effectiveness in the Northern Sierra Nevada, CA, USA

    Science.gov (United States)

    Dow, Christopher B.; Collins, Brandon M.; Stephens, Scott L.

    2016-03-01

    Finding novel ways to plan and implement landscape-level forest treatments that protect sensitive wildlife and other key ecosystem components, while also reducing the risk of large-scale, high-severity fires, can prove to be difficult. We examined alternative approaches to landscape-scale fuel-treatment design for the same landscape. These approaches included two different treatment scenarios generated from an optimization algorithm that reduces modeled fire spread across the landscape, one with resource-protection constrains and one without the same. We also included a treatment scenario that was the actual fuel-treatment network implemented, as well as a no-treatment scenario. For all the four scenarios, we modeled hazardous fire potential based on conditional burn probabilities, and projected fire emissions. Results demonstrate that in all the three active treatment scenarios, hazardous fire potential, fire area, and emissions were reduced by approximately 50 % relative to the untreated condition. Results depict that incorporation of constraints is more effective at reducing modeled fire outputs, possibly due to the greater aggregation of treatments, creating greater continuity of fuel-treatment blocks across the landscape. The implementation of fuel-treatment networks using different planning techniques that incorporate real-world constraints can reduce the risk of large problematic fires, allow for landscape-level heterogeneity that can provide necessary ecosystem services, create mixed forest stand structures on a landscape, and promote resilience in the uncertain future of climate change.

  7. Pedological and geological relationships with soil lichen and moss distribution in the eastern Mojave Desert, CA, USA

    Science.gov (United States)

    Belnap, Jayne; Miller, David M.; Bedford, David R.; Phillips, Susan L.

    2014-01-01

    Biological soil crusts (biocrusts) are ubiquitous in drylands globally. Lichens and mosses are essential biocrust components and provide a variety of ecosystem services, making their conservation and management of interest. Accordingly, understanding what factors are correlated with their distribution is important to land managers. We hypothesized that cover would be related to geologic and pedologic factors. We sampled 32 sites throughout the eastern Mojave Desert, stratifying by parent material and the age of the geomorphic surfaces. The cover of lichens and mosses on ‘available ground’ (L + Mav; available ground excludes ground covered by rocks or plant stems) was higher on limestone and quartzite-derived soils than granite-derived soils. Cover was also higher on moderately younger-aged geomorphic surfaces (Qya2, Qya3, Qya4) and cutbanks than on very young (Qya1), older-aged surfaces (Qia1, Qia2), or soils associated with coppice mounds or animal burrowing under Larrea tridentata. When all sites and parent materials were combined, soil texture was the most important factor predicting the occurrence of L + Mav, with cover positively associated with higher silt, very fine sand, and fine sand fractions and negatively associated with the very coarse sand fraction. When parent materials were examined separately, nutrients such as available potassium, iron, and calcium became the most important predictors of L + Mav cover.

  8. Antibody engineering & therapeutics, the annual meeting of the antibody society December 7–10, 2015, San Diego, CA, USA

    Science.gov (United States)

    Pauthner, Matthias; Yeung, Jenny; Ullman, Chris; Bakker, Joost; Wurch, Thierry; Reichert, Janice M.; Lund-Johansen, Fridtjof; Bradbury, Andrew R.M.; Carter, Paul J.; Melis, Joost P.M.

    2016-01-01

    ABSTRACT The 26th Antibody Engineering & Therapeutics meeting, the annual meeting of The Antibody Society united over 800 participants from all over the world in San Diego from 6–10 December 2015. The latest innovations and advances in antibody research and development were discussed, covering a myriad of antibody-related topics by more than 100 speakers, who were carefully selected by The Antibody Society. As a prelude, attendees could join the pre-conference training course focusing, among others, on the engineering and enhancement of antibodies and antibody-like scaffolds, bispecific antibody engineering and adaptation to generate chimeric antigen receptor constructs. The main event covered 4 d of scientific sessions that included antibody effector functions, reproducibility of research and diagnostic antibodies, new developments in antibody-drug conjugates (ADCs), preclinical and clinical ADC data, new technologies and applications for bispecific antibodies, antibody therapeutics for non-cancer and orphan indications, antibodies to harness the cellular immune system, building comprehensive IgVH-gene repertoires through discovering, confirming and cataloging new germline IgVH genes, and overcoming resistance to clinical immunotherapy. The Antibody Society's special session focused on “Antibodies to watch” in 2016. Another special session put the spotlight on the limitations of the new definitions for the assignment of antibody international nonproprietary names introduced by the World Health Organization. The convention concluded with workshops on computational antibody design and on the promise and challenges of using next-generation sequencing for antibody discovery and engineering from synthetic and in vivo libraries. PMID:26909869

  9. Characterization of Chemosynthetic Microbial Mats Associated with Intertidal Hydrothermal Sulfur Vents in White Point, San Pedro, CA, USA

    Science.gov (United States)

    Miranda, Priscilla J.; McLain, Nathan K.; Hatzenpichler, Roland; Orphan, Victoria J.; Dillon, Jesse G.

    2016-01-01

    The shallow-sea hydrothermal vents at White Point (WP) in Palos Verdes on the southern California coast support microbial mats and provide easily accessed settings in which to study chemolithoautotrophic sulfur cycling. Previous studies have cultured sulfur-oxidizing bacteria from the WP mats; however, almost nothing is known about the in situ diversity and activity of the microorganisms in these habitats. We studied the diversity, micron-scale spatial associations and metabolic activity of the mat community via sequence analysis of 16S rRNA and aprA genes, fluorescence in situ hybridization (FISH) microscopy and sulfate reduction rate (SRR) measurements. Sequence analysis revealed a diverse group of bacteria, dominated by sulfur cycling gamma-, epsilon-, and deltaproteobacterial lineages such as Marithrix, Sulfurovum, and Desulfuromusa. FISH microscopy suggests a close physical association between sulfur-oxidizing and sulfur-reducing genotypes, while radiotracer studies showed low, but detectable, SRR. Comparative 16S rRNA gene sequence analyses indicate the WP sulfur vent microbial mat community is similar, but distinct from other hydrothermal vent communities representing a range of biotopes and lithologic settings. These findings suggest a complete biological sulfur cycle is operating in the WP mat ecosystem mediated by diverse bacterial lineages, with some similarity with deep-sea hydrothermal vent communities. PMID:27512390

  10. Effect of Submarine Groundwater Discharge on Bacterial Indicators and Swimmer Health at Avalon Beach,CA,USA

    Science.gov (United States)

    Use of fecal indicator bacteria (FIB) for monitoring beach water quality is based on their co-occurrence with human pathogens, a relationship which can be dramatically altered by fate and transport processes after leaving the human intestine. We conducted a prospective cohort st...

  11. Two Years of Simultaneous K(sub a)-Band Measurements: Goldstone, CA; White Sands, NM; and Guam, USA

    Science.gov (United States)

    Acosta, Roberto J.; Zemba, M.; Morse, J.; Nessel, J.

    2012-01-01

    In order to statistically characterize the effect of the Earth's atmosphere on Ka-Band links, site test interferometers (STIs) have been deployed at three of NASA s operational sites to directly measure each site's tropospheric phase stability and rain attenuation. These STIs are composed of two antennas on a short baseline (less than 1km) that observe the same unmodulated beacon signal broadcast from a geostationary satellite (e.g., Anik F2). The STIs are used to measure the differential phase between the two received signals as well as the individual signal attenuation at each terminal. There are currently three NASA sites utilizing STIs; the Goldstone Deep Space Communications Complex near Barstow, California; the White Sands Complex in Las Cruces, New Mexico; and the Guam Remote Ground Terminal on the island of Guam. The first two sites are both located in desert regions that have highly similar climates in terms of their seasonal temperatures, average humidity, and annual rain fall (the primary factors in determining phase stability). In contrast, Guam is in a tropical region with drastically higher annual rainfall and humidity. Five station years of data have been collected in Goldstone, three in White Sands, and two in Guam, yielding two years of simultaneous data collection across all three sites. During this period of simultaneous data collection, the root-mean-square (RMS) of the time delay fluctuations stayed under 2.40 picoseconds for 90% of the time in Goldstone, under 2.07 picoseconds for 90% of the time in White Sands, and under 10.13 picoseconds for 90% of the time in Guam. For the 99th percentile, the statistics were 6.32 ps, 6.03 ps, and 24.85 ps, respectively. These values, as well as various other site quality characteristics, will be used to determine the suitability of these sites for NASA s future communication services at Ka-Band.

  12. Temporal and spatial distributions of sediment mercury at salt pond wetland restoration sites, San Francisco Bay, CA, USA

    Science.gov (United States)

    Miles, A.K.; Ricca, M.A.

    2010-01-01

    Decommissioned agricultural salt ponds within south San Francisco Bay, California, are in the process of being converted to habitat for the benefit of wildlife as well as water management needs and recreation. Little is known of baseline levels of contaminants in these ponds, particularly mercury (Hg), which has a well established legacy in the Bay. In this study we described spatial and short-term temporal variations in sediment Hg species concentrations within and among the Alviso and Eden Landing salt ponds in the southern region of San Francisco Bay. We determined total Hg (Hgt) and methylmercury (MeHg) in the top 5 cm of sediment of most ponds in order to establish baseline conditions prior to restoration, sediment Hgt concentrations in a subset of these ponds after commencement of restoration, and variation in MeHg concentrations relative to sediment Hgt, pH, and total Fe concentrations and water depth and salinity in the subset of Alviso ponds. Inter-pond differences were greatest within the Alviso pond complex, where sediment Hgt concentrations averaged (arithmetic mean) 0.74 ??g/g pre and 1.03 ??g/g post-restoration activity compared to 0.11 ??g/g pre and post at Eden Landing ponds. Sediment Hgt levels at Alviso were fairly stable temporally and spatially, whereas MeHg levels were variable relative to restoration activities across time and space. Mean (arithmetic) sediment MeHg concentrations increased (2.58 to 3.03 ng/g) in Alviso and decreased (2.20 to 1.03 ng/g) in Eden Landing restoration ponds during the study. Differences in MeHg levels were related to water depth and pH, but these relationships were not consistent between years or among ponds and were viewed with caution. Factors affecting MeHg levels in these ponds (and in general) are highly complex and require in-depth study to understand.

  13. Gauging climate preparedness to inform adaptation needs: local level adaptation in drinking water quality in CA, USA.

    Science.gov (United States)

    Ekstrom, Julia A; Bedsworth, Louise; Fencl, Amanda

    2017-01-01

    Understanding resource managers' perceptions of climate change, analytic capacity, and current adaptation activities can provide insight into what can help support adaptation processes at the local level. In California, where a major drought currently demonstrates some of the hardships that could be regularly encountered under a changing climate, we present results from a survey of drinking water utilities about the perceived threat, analytic capacity, and adaptation actions related to maintaining water quality in the face of climate change. Among surveyed utilities (n = 259), awareness is high in regard to climate change occurring and its potential impacts on water quality globally, but perceived risk is lower with regard to climate impacts on local drinking water quality. Just over half of surveyed utilities report at least some adaptation activity to date. The top three variables that most strongly correlated with reported adaptation action were (1) perceived risk on global and local water quality, (2) surface water reliance, and (3) provision of other services beyond drinking water. Other tested variables significantly correlated with reported adaptation action were (4) degree of impact from the current drought and (5) communication with climate change experts. Findings highlight that smaller groundwater-reliant utilities may need the most assistance to initiate climate adaptation processes. Trusted information sources most frequently used across respondents were state government agencies, followed by colleagues in the same utilities. The finding that frequently used sources of information are similar across utilities presents a promising opportunity for training and disseminating climate information to assist those systems needing the most support.

  14. Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society December 7-10, 2015, San Diego, CA, USA.

    Science.gov (United States)

    Pauthner, Matthias; Yeung, Jenny; Ullman, Chris; Bakker, Joost; Wurch, Thierry; Reichert, Janice M; Lund-Johansen, Fridtjof; Bradbury, Andrew R M; Carter, Paul J; Melis, Joost P M

    2016-01-01

    The 26th Antibody Engineering & Therapeutics meeting, the annual meeting of The Antibody Society united over 800 participants from all over the world in San Diego from 6-10 December 2015. The latest innovations and advances in antibody research and development were discussed, covering a myriad of antibody-related topics by more than 100 speakers, who were carefully selected by The Antibody Society. As a prelude, attendees could join the pre-conference training course focusing, among others, on the engineering and enhancement of antibodies and antibody-like scaffolds, bispecific antibody engineering and adaptation to generate chimeric antigen receptor constructs. The main event covered 4 d of scientific sessions that included antibody effector functions, reproducibility of research and diagnostic antibodies, new developments in antibody-drug conjugates (ADCs), preclinical and clinical ADC data, new technologies and applications for bispecific antibodies, antibody therapeutics for non-cancer and orphan indications, antibodies to harness the cellular immune system, building comprehensive IgVH-gene repertoires through discovering, confirming and cataloging new germline IgVH genes, and overcoming resistance to clinical immunotherapy. The Antibody Society's special session focused on "Antibodies to watch" in 2016. Another special session put the spotlight on the limitations of the new definitions for the assignment of antibody international nonproprietary names introduced by the World Health Organization. The convention concluded with workshops on computational antibody design and on the promise and challenges of using next-generation sequencing for antibody discovery and engineering from synthetic and in vivo libraries.

  15. Modeling landslide recurrence in Seattle, Washington, USA

    Science.gov (United States)

    Salciarini, Diana; Godt, Jonathan W.; Savage, William Z.; Baum, Rex L.; Conversini, Pietro

    2008-01-01

    To manage the hazard associated with shallow landslides, decision makers need an understanding of where and when landslides may occur. A variety of approaches have been used to estimate the hazard from shallow, rainfall-triggered landslides, such as empirical rainfall threshold methods or probabilistic methods based on historical records. The wide availability of Geographic Information Systems (GIS) and digital topographic data has led to the development of analytic methods for landslide hazard estimation that couple steady-state hydrological models with slope stability calculations. Because these methods typically neglect the transient effects of infiltration on slope stability, results cannot be linked with historical or forecasted rainfall sequences. Estimates of the frequency of conditions likely to cause landslides are critical for quantitative risk and hazard assessments. We present results to demonstrate how a transient infiltration model coupled with an infinite slope stability calculation may be used to assess shallow landslide frequency in the City of Seattle, Washington, USA. A module called CRF (Critical RainFall) for estimating deterministic rainfall thresholds has been integrated in the TRIGRS (Transient Rainfall Infiltration and Grid-based Slope-Stability) model that combines a transient, one-dimensional analytic solution for pore-pressure response to rainfall infiltration with an infinite slope stability calculation. Input data for the extended model include topographic slope, colluvial thickness, initial water-table depth, material properties, and rainfall durations. This approach is combined with a statistical treatment of rainfall using a GEV (General Extreme Value) probabilistic distribution to produce maps showing the shallow landslide recurrence induced, on a spatially distributed basis, as a function of rainfall duration and hillslope characteristics.

  16. Levels of CEA, CA153, CA199, CA724 and AFP in nipple discharge of breast cancer patients.

    Science.gov (United States)

    Zhao, Song; Mei, Yu; Wang, Yongmei; Zhu, Jiang; Zheng, Guixi; Ma, Rong

    2015-01-01

    The distinction between breast cancer and benign breast diseases with nipple discharge remains an important diagnostic challenge. The purpose of this study was to predict the potential usefulness of tumor markers in nipple discharge and to investigate the relationship of tumor markers and clinical characteristics with breast cancer.One hundred and eleven patients with nipple discharge received breast surgery from November 2013 to December 2014 were included in the study. We evaluated levels of five tumor markers (CEA, CA153, CA199, CA724 and AFP) prior to treatment. Patients were divided into two groups according to postoperative pathological results: 30 cases in breast cancer group and 81 cases in benign group. The relationships of clinical characteristics with breast cancer were investigated by multivariate analysis with a logistic regression model.It showed significant differences in levels of nipple discharge CEA (P AFP (P = 0.834) among two groups. Logistic regression analysis demonstrated complaint, age, menopause, abnormal palpable mass, CEA and CA153 were associated with breast cancer. In summary, measurements of CA199, CA724 and AFP in nipple discharge are not of great clinical value. Detecting CEA and CA153 in nipple dischargecould potentially be used for the early detection of breast cancer with in high-risk populations.

  17. SR-targeted CaMKII inhibition improves SR Ca2+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC

    OpenAIRE

    Huke, Sabine; DeSantiago, Jaime; Kaetzel, Marcia A.; Mishra, Shikha; Brown, Joan H.; Dedman, John R.; Bers, Donald M.

    2010-01-01

    Cardiac myocyte overexpression of CaMKIIδC leads to cardiac hypertrophy and heart failure (HF) possibly caused by altered myocyte Ca2+ handling. A central defect might be the marked CaMKII-induced increase in diastolic sarcoplasmic reticulum (SR) Ca2+ leak which decreases SR Ca2+ load and Ca2+ transient amplitude. We hypothesized that inhibition of CaMKII near the SR membrane would decrease the leak, improve Ca2+ handling and prevent the development of contractile dysfunction and HF. To test ...

  18. Results of measuring internal Ca absorption and Ca kinetics with /sup 47/Ca in patients suffering from chronically recurrent urolithiasis

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, L.; Esther, G.; Serfling, D.; Bast, R. (Rostock Univ. (German Democratic Republic). Radiologische Klinik)

    1983-07-01

    47 patients with chronically recurrent calcium lithiasis (with between 3 and over 100 stone episodes) and an average age of 43.2 years have been examined. The Ca absorption lay between 42.7% and 90.0% of the dose, the average was 59.3% with a standard deviation of +- 12.9. This is higher than in persons with healthy kidneys. The Ca absorption is significantly lower in patients with renal insufficiency. Studies on Ca kinetics revealed turnover rates and pool sizes within the normal range.

  19. Isospin effects in {sup 40,48}Ca+{sup 40,48}Ca collisions

    Energy Technology Data Exchange (ETDEWEB)

    Henzl, V., E-mail: henzl@mit.ed [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Henzlova, D.; Kilburn, M. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Verde, G. [INFN, Sezione di Catania. 64 Via S. Sofia, I-95123, Catania (Italy); Brown, D. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Chbihi, A. [GANIL, CEA et IN2P3-CNRS, B.P. 5027, F-14076 Caen Cedex (France); Coupland, D. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Elson, J. [Departments of Chemistry and Physics, Washington University, St. Louis, MO 63130 (United States); Famiano, M. [Western Michigan University, 2229 Everett Tower, Kalamazoo, MI 49008-5252 (United States); Herlitzius, C. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Hudan, S. [Indiana Univ. Cyclotron Facility, 2401 Milo B. Sampson Lane, Bloomington, IN 47405-4001 (United States); Lee, J.; Lukyanov, S.; Lynch, W.; Rogers, A.; Sanetullaev, A. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States); Sobotka, L. [Departments of Chemistry and Physics, Washington University, St. Louis, MO 63130 (United States); Souza, R.T. de [Indiana Univ. Cyclotron Facility, 2401 Milo B. Sampson Lane, Bloomington, IN 47405-4001 (United States); Sun, Z.Y.; Tsang, B. [MSU-NSCL, 1 Cyclotron, East Lansing MI, 48824 (United States)

    2010-03-01

    The isospin dependence of two proton correlations is studied in {sup 40}Ca+{sup 40}Ca and {sup 48}Ca+{sup 48}Ca collisions at E/A=80MeV. Measurements were performed with the HiRA detector array complemented by the 4pi Ball at NSCL. We observe a strong isospin dependence of the pp-correlation functions; however the emitting source radius extracted using the imaging technique yields no sensitivity to the isospin of the reaction system. We interpret this result as a consequence of smaller fraction of fast proton emission in the neutron rich {sup 48}Ca system.

  20. Toosendanin increases free-Ca2+ concentration in NG108-15 cells via L-type Ca2+ channels

    Institute of Scientific and Technical Information of China (English)

    Tong-hui XU; Jun DING; Yu-liang SHI

    2004-01-01

    AIM: To examine if toosendanin (TSN) affects intracellular free-Ca2+ concentration ([Ca2+]i) in neuroblastomaxglioma hybrid cells (NG108-15 cells). METHODS: The [Ca2+]i was determined by laser-scanning confocal microscopic imaging technique in which Fluo-3 was used as Ca2+ indicator. RESULTS: TSN induced an increase in resting [Ca2+]i and in high K+-evoked Ca2+ transient in differentiated NG108-15 cells. The TSN-induced increase in [Ca2+]i was dose-dependent and disappeared in CdCl2-, nifedipine-containing or Ca2+-free solution, and appeared after washing out the Ca2+ channel blockers or adding Ca2+. CONCLUSION: TSN increased [Ca2+]i in differentiated NG108-15 cells. The [Ca2+]i enhancement was due to the influx of extracellular Ca2+ and related to L-type Ca2+ channels.

  1. A comparison of fluorescent Ca2+ indicators for imaging local Ca2+ signals in cultured cells

    Science.gov (United States)

    Lock, Jeffrey T.; Parker, Ian

    2015-01-01

    Localized subcellular changes in Ca2+ serve as important cellular signaling elements, regulating processes as diverse as neuronal excitability and gene expression. Studies of cellular Ca2+ signaling have been greatly facilitated by the availability of fluorescent Ca2+ indicators. The respective merits of different indicators to monitor bulk changes in cellular Ca2+ levels have been widely evaluated, but a comprehensive comparison for their use in detecting and analyzing local, subcellular Ca2+ signals is lacking. Here, we evaluated several fluorescent Ca2+ indicators in the context of local Ca2+ signals (puffs) evoked by inositol 1,4,5-trisphosphate (IP3) in cultured human neuroblastoma SH-SY5Y cells, using high-speed video-microscopy. Altogether, nine synthetic Ca2+ dyes (Fluo-4, Fluo-8, Fluo-8 high affinity, Fluo-8 low affinity, Oregon Green BAPTA-1, Cal-520, Rhod-4, Asante Calcium Red, and X-Rhod-1) and three genetically-encoded Ca2+-indicators (GCaMP6-slow, -medium and -fast variants) were tested; criteria include the magnitude, kinetics, signal-to-noise ratio and detection efficiency of local Ca2+ puffs. Among these, we conclude that Cal-520 is the optimal indicator for detecting and faithfully tracking local events; that Rhod-4 is the red-emitting indicator of choice; and that none of the GCaMP6 variants are well suited for imaging subcellular Ca2+ signals. PMID:26572560

  2. Behavior of CaO and Calcium in pure Magnesium

    Institute of Scientific and Technical Information of China (English)

    HA Seong-Ho; LEE Jin-Kyu; JO Hyung-Ho; JUNG Seung-Boo; KIM Shae K.

    2006-01-01

    Mg alloys exhibit a number of good properties such as low density, good castability and high specific strength.However, molten Mg and Mg alloys are ignited without the melt protective gases during melting and casting process due to their high reactivity.The purpose of this study is to investigate effects of Ca and CaO on pure Mg through microstructure observation, ignition test and phase analysis.With increasing Ca and CaO contents, the ignition resistance of Ca or CaO added pure Mg is increased and the grains are refined.As results of XRD and EDS, CaO is reduced to Ca in CaO added pure Mg.Mg2Ca phase is formed even in 0.1 wt.%CaO added pure Mg by reduction mechanism, while Mg2Ca phase is formed over 1.35 wt.% Ca added pure Mg.

  3. Ca2+ sparks and Ca2+ glows in superior cervical ganglion neurons

    Institute of Scientific and Technical Information of China (English)

    Li-jun YAO; Cai-hong WU; Jie LIU; Zhuan ZHOU; He-ping CHENG; Gang WANG; Kun-fu OU-YANG; Chao-liang WEI; Xian-hua WANG; Shi-rong WANG; Wei YAO; Hong-ping HUANG; Jian-hong LUO

    2006-01-01

    Aim: Ca2+ release from the endoplasmic reticulum (ER) is an integral component of neuronal Ca2+ signaling. The present study is to investigate properties of local Ca2+ release events in superior cervical ganglion (SCO) neurons. Methods: Primary cultured SCO neurons were prepared from neonatal rats (P3-P7). Low concentration of caffeine was used to induce Ca2+ release from the ER Ca2+ store, and intracellular Ca2+ was recorded by high-resolution line scan confocal imaging and the Ca2+ indicator Fluo-4. Results: Two populations of local Ca2+ release events with distinct temporal characteristics were evoked by 1.5 mmol/L caffeine near the surface membrane in the soma and the neurites of SCG neurons. Brief events similar to classic Ca2+ sparks lasted a few hundreds of milliseconds, whereas long-lasting events displayed duration up to tens of seconds. Typical somatic and neurite sparks were of 0.3- and 0.52-fold increase in local Fluo-4 fluorescence, respectively. Typical Ca2+ glows were brighter (△F/F0 approximately 0.6), but were highly confined in space. The half maximum of full duration of neurite sparks was much longer than those in the soma (685 vs 381 ms). Conclusion: Co-existence of Ca2+ sparks and Ca2+ glows in SCG neurons indicates distinctive local regulation of Ca2+ release kinetics. The local Ca2+ signals of variable, site-specific temporal length may bear important implications in encoding a "memory" of the trigger signal.

  4. Serum level of TSGF,CA242 and CA19-9 in pancreatic cancer

    Institute of Scientific and Technical Information of China (English)

    Jing-Ting Jiang; Chang-Ping Wu; Hai-Feng Deng; Ming-Yang Lu; Jun Wu; Hong-Yu Zhang; Wen-Hui Sun; Mei Ji

    2004-01-01

    AIM: To establish a method to detect the expression of the tumor specific growth factor TSGF, CA242 and CA19-9 in serum and evaluate their value in diagnosis of pancreatic cancer.METHODS: ELISA and Biochemical colorimetric assay were used to detect the serum content of TSGF, CA242 and CA19-9 in 200 normal cases, 52 pancreatitis patients and 96 pancreatic cancer patients.RESULTS: The positive likelihood ratios of TSGF, CA242and CA19-9 were 5.4, 12.6 and 6.3, respectively, and their negative likelihood ratios were 0.10, 0.19 and 0.17,respectively. With single tumor marker diagnosed pancreatic cancer, the highest sensitivity and specificity of TSGF were 91.6% and 93.5%. In combined test with 3 markers, when all of them were positive, the sensitivity changed to 77.0%and the specificity and the positive predictive value were 100%. The levels of TSGF and CA242 were significantly higher in the patients with pancreatic cancer of head than those in the patients with pancreatic cancer of body, tail and whole pancreas, but the expression of CA19-9 had no correlation with the positions of the pancreatic cancer. The sensitivity of TSGF, CA242 and CA19-9 was increased with the progress in stages of pancreatic cancer. In stage I, the sensitivity of TSGF was markedly higher than CA242 and CA19-9.CONCLUSION: The combined use of TSGF, CA242 and CA19-9 expressions can elevate the specificity for pancreatic cancer diagnosis. And it shows that it plays an important role to differentiate positions and tissue typing. It is a forepart diagnosis for the pancreatic cancer by combination checking.There is very important correlation between the three markers and the pancreatic cancer.

  5. The Elk Creek Carbonatite Complex, Nebraska (USA)

    Science.gov (United States)

    Kettler, R. M.; Blessington, M.

    2015-12-01

    The Elk Creek carbonatite complex (ECCC) is a large Early Cambrian carbonatite-alkaline syenite complex located in SE Nebraska (USA). The carbonatite and related rocks are buried by more than 200 m of Pennsylvanian marine sedimentary rocks and Quaternary till. The pre-Pennsylvanian sub-crop is crudely circular in plan-view and exceeds 30 km2, making it one of the larger carbonatite complexes in North America. The rocks of the complex were intruded in Precambrian granite and gneiss on the eastern margin of the Mid-Continent rift where it has been offset by one of a series of southeasterly trending structures. The primary rock type in the ECCC is dolomite carbonatite. The dolomite carbonatite ranges from fine-grained flow-banded dolomite to a coarse-grained rock comprising large prismatic dolomite crystals. The central portion of the complex comprises a pipe-like intrusion of magnetite dolomite carbonatite and magnetite dolomite carbonatite breccia. Magnetite dolomite carbonatite is typically fine-grained and contains angular or rounded elongate fragments of dolomite carbonatite. Fragments of magnetite dolomite carbonatite are also included in dolomite carbonatite and other carbonatite rocks in the complex. Emplacement of a discreet pulse of reduced, iron-rich carbonatite magma was, therefore, a likely early event in the evolution of the ECCC. The magnetite is altered locally to hematite and other iron oxides. The oxidation ranges from a dusting of hematite to pervasive alteration to hematite and ferric oxyhydroxides and occurs to depths as much as 630 m below the modern land surface. Other volumetrically important rock types include apatite dolomite carbonatite and barite dolomite carbonatite. Both of these rock types are localized largely along fractures, occur later in the intrusive sequence, and may reflect exsolution of phosphates and sulfates with decreasing temperatures. The magnetite dolomite carbonatite hosts significant pyrochlore mineralization. Microprobe

  6. Volcano geodesy in the Cascade arc, USA

    Science.gov (United States)

    Poland, Michael P.; Lisowski, Michael; Dzurisin, Daniel; Kramer, Rebecca; McLay, Megan; Pauk, Ben

    2017-08-01

    Experience during historical time throughout the Cascade arc and the lack of deep-seated deformation prior to the two most recent eruptions of Mount St. Helens might lead one to infer that Cascade volcanoes are generally quiescent and, specifically, show no signs of geodetic change until they are about to erupt. Several decades of geodetic data, however, tell a different story. Ground- and space-based deformation studies have identified surface displacements at five of the 13 major Cascade arc volcanoes that lie in the USA (Mount Baker, Mount St. Helens, South Sister, Medicine Lake, and Lassen volcanic center). No deformation has been detected at five volcanoes (Mount Rainier, Mount Hood, Newberry Volcano, Crater Lake, and Mount Shasta), and there are not sufficient data at the remaining three (Glacier Peak, Mount Adams, and Mount Jefferson) for a rigorous assessment. In addition, gravity change has been measured at two of the three locations where surveys have been repeated (Mount St. Helens and Mount Baker show changes, while South Sister does not). Broad deformation patterns associated with heavily forested and ice-clad Cascade volcanoes are generally characterized by low displacement rates, in the range of millimeters to a few centimeters per year, and are overprinted by larger tectonic motions of several centimeters per year. Continuous GPS is therefore the best means of tracking temporal changes in deformation of Cascade volcanoes and also for characterizing tectonic signals so that they may be distinguished from volcanic sources. Better spatial resolution of volcano deformation can be obtained through the use of campaign GPS, semipermanent GPS, and interferometric synthetic aperture radar observations, which leverage the accumulation of displacements over time to improve signal to noise. Deformation source mechanisms in the Cascades are diverse and include magma accumulation and withdrawal, post-emplacement cooling of recent volcanic deposits, magmatic

  7. Volcano geodesy in the Cascade arc, USA

    Science.gov (United States)

    Poland, Michael; Lisowski, Michael; Dzurisin, Daniel; Kramer, Rebecca; McLay, Megan; Pauk, Benjamin

    2017-01-01

    Experience during historical time throughout the Cascade arc and the lack of deep-seated deformation prior to the two most recent eruptions of Mount St. Helens might lead one to infer that Cascade volcanoes are generally quiescent and, specifically, show no signs of geodetic change until they are about to erupt. Several decades of geodetic data, however, tell a different story. Ground- and space-based deformation studies have identified surface displacements at five of the 13 major Cascade arc volcanoes that lie in the USA (Mount Baker, Mount St. Helens, South Sister, Medicine Lake, and Lassen volcanic center). No deformation has been detected at five volcanoes (Mount Rainier, Mount Hood, Newberry Volcano, Crater Lake, and Mount Shasta), and there are not sufficient data at the remaining three (Glacier Peak, Mount Adams, and Mount Jefferson) for a rigorous assessment. In addition, gravity change has been measured at two of the three locations where surveys have been repeated (Mount St. Helens and Mount Baker show changes, while South Sister does not). Broad deformation patterns associated with heavily forested and ice-clad Cascade volcanoes are generally characterized by low displacement rates, in the range of millimeters to a few centimeters per year, and are overprinted by larger tectonic motions of several centimeters per year. Continuous GPS is therefore the best means of tracking temporal changes in deformation of Cascade volcanoes and also for characterizing tectonic signals so that they may be distinguished from volcanic sources. Better spatial resolution of volcano deformation can be obtained through the use of campaign GPS, semipermanent GPS, and interferometric synthetic aperture radar observations, which leverage the accumulation of displacements over time to improve signal to noise. Deformation source mechanisms in the Cascades are diverse and include magma accumulation and withdrawal, post-emplacement cooling of recent volcanic deposits, magmatic

  8. China / USA - Climate at stake; Chine / USA - Le climat en jeu

    Energy Technology Data Exchange (ETDEWEB)

    Marechal, Jean-Paul

    2011-10-15

    Climate change is one of the major challenge that humanity will have to take up during the coming decades. The preparation in 2012 of the 'post-Kyoto' era, where all countries would take up their climate responsibilities, remains the hardest trial. However, all successive international summits did not lead to any constraining agreement between countries. The main reason is the rivalry and dependence relation which links China and the USA. It is now obvious that no major climate decision can be taken without the double determined commitment of these both giants, and so far it is not in their interest to lead by example. This book analyses the freeze of this situation in an historical perspective and identifies some paths of solution to this serious problem. (J.S.)

  9. USA-Canada free trade agreement and energy problem

    Energy Technology Data Exchange (ETDEWEB)

    Ogushi, Nobuyuki

    1988-11-01

    The USA and Canada occupying approx. 70 and 20%, respectively, of the export/import amount of the opponent country, the free trade agreement is regarded as a matter of course, also judging from the geographical condition between both countries. Energywise to analyze the influence of that agreement, if concluded, as for oil, Canada is exporting 30% of produced oil to the USA, which will not be influential in the short term. However in the long term, it will be problematic as the oil reserve is being exhausted in Canada. As for natural gas, Canadian supply of natural gas to the USA being in excess at present, the agreement, if concluded, would be influential on the present disturbance to be solved. Canada exports 9% of produced electric power to the USA, where there domestically exist pros and cons of the liberalization of power importation. By the agreement if concluded, the USA will be assured of the stable supply of uranium and exempt from the required uranium manufacture. But the conclusion of agreement, depending upon the political situation in Canada, is not easily predictable. 8 tables.

  10. Evolving plans for the USA National Phenology Network

    Science.gov (United States)

    Betancourt, Julio L.; Schwartz, Mark D.; Breshears, David D.; Brewer, Carol A.; Frazer, Gary; Gross, John E.; Mazer, Susan J.; Reed, Bradley C.; Wilson, Bruce E.

    2007-01-01

    Phenology is the study of periodic plant and animal life cycle events, how these are influenced by seasonal and interannual variations in climate, and how they modulate the abundance, diversity, and interactions of organisms. The USA National Phenology Network (USA-NPN) is currently being organized to engage federal agencies, environmental networks and field stations, educational institutions, and citizen scientists. The first USA-NPN planning workshop was held August 2005, in Tucson, Ariz. (Betancourt et al. [2005]; http://www.uwm.edu/Dept/Geography/npn/; by 1 June 2007, also see http://www.usanpn.org). With sponsorship from the U.S. National Science Foundation, the U.S. Geological Survey (USGS), the U.S. Fish and Wildlife Service, and NASA, the second USA-NPN planning workshop was held at the University of Wisconsin-Milwaukee on 10–12 October 2006 to (1) develop lists of target species and observation protocols; (2) identify existing networks that could comprise the backbone of nationwide observations by 2008; (3) develop opportunities for education, citizen science, and outreach beginning in spring 2007; (4) design strategies for implementing the remote sensing component of USA-NPN; and (5) draft a data management and cyberinfrastructure plan.

  11. Evidence-Based Redesign of the COMLEX-USA Series.

    Science.gov (United States)

    Gimpel, John R; Horber, Dorothy; Sandella, Jeanne M; Knebl, Janice A; Thornburg, John E

    2017-04-01

    To ensure that the Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) reflects the evolving practice of osteopathic medicine, the National Board of Osteopathic Medical Examiners has developed new content and format specifications for an enhanced, competency-based examination program to be implemented with COMLEX-USA Level 3 in 2018. This article summarizes the evidence-based design processes that served as the foundation for blueprint development and the evidence supporting its validity. An overview is provided of the blueprint's 2 dimensions: Competency Domains and Clinical Presentations. The authors focus on the evidence that supports interpretation of test scores for the primary and intended purpose of COMLEX-USA, which is osteopathic physician licensure. Important secondary uses and the educational and catalytic effect of assessments are also described. This article concludes with the National Board of Osteopathic Medical Examiners' plans to ensure that the COMLEX-USA series remains current and meets the needs of its stakeholders-the patients who seek care from osteopathic physicians.

  12. The origins of migrations of Albanians in USA

    Directory of Open Access Journals (Sweden)

    Naim Seferi

    2016-07-01

    Full Text Available The Albanians started to migrate in the US at the end of XIX-th century and beginning of XX-th century. The reasons of emigration were the persecutions carried out by Ottoman Empire as well as the Balkan countries which tried to take advantage of the weakening of Ottoman Empire. Migrations were also common from the Balkan countries such as Romania, Bulgaria, and Greece to USA. The migrations of Albanians in the US started very early when they initially emigrated from Albania into various countries and from there they continued their way to USA. In the archives of the USA they were recorded as people of countries from where they were coming, based on the passports issued by the country they migrated to and the Albanians, who were under the occupation of Ottoman empire, would be registered as Ottomans due to their Ottoman documentations whereas the Albanians of Orthodox religion would be registered as Greek in the USA. Main purpose of this study is the analysis of the origins of emigration of Albanians in USA.

  13. Study on Roasting Decomposition of Mixed Rare Earth Concentrate in CaO-NaCl-CaCl2

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The decomposed process of bastnaesite, monazite and mixed rare earth concentrate in CaO-CaCl-CaCl2 was studied by means of TG-DTA method. The relationship among decomposition ratio, roasting temperature, and CaO-NaCl addition was studied by the quadratic regression orthogonal analysis, and then the regression equation was obtained. Through analysis, the optimum process conditions of mixed rare earth concentrate decomposed by CaO-CaCl-CaCl2 were obtained as follows: roasting temperature: 700 ℃, CaO addition: 15%, NaCl-CaCl2 addition: 10%, roasting time: 60 min, the decomposition ratio: 91.3%.

  14. Aging and CaMKII Alter Intracellular Ca2+ Transients and Heart Rhythm in Drosophila melanogaster

    Science.gov (United States)

    Santalla, Manuela; Valverde, Carlos A.; Harnichar, Ezequiel; Lacunza, Ezequiel; Aguilar-Fuentes, Javier; Mattiazzi, Alicia; Ferrero, Paola

    2014-01-01

    Aging is associated to disrupted contractility and rhythmicity, among other cardiovascular alterations. Drosophila melanogaster shows a pattern of aging similar to human beings and recapitulates the arrhythmogenic conditions found in the human heart. Moreover, the kinase CaMKII has been characterized as an important regulator of heart function and an arrhythmogenic molecule that participate in Ca2+ handling. Using a genetically engineered expressed Ca2+ indicator, we report changes in cardiac Ca2+ handling at two different ages. Aging prolonged relaxation, reduced spontaneous heart rate (HR) and increased the occurrence of arrhythmias, ectopic beats and asystoles. Alignment between Drosophila melanogaster and human CaMKII showed a high degree of conservation and indicates that relevant phosphorylation sites in humans are also present in the fruit fly. Inhibition of CaMKII by KN-93 (CaMKII-specific inhibitor), reduced HR without significant changes in other parameters. By contrast, overexpression of CaMKII increased HR and reduced arrhythmias. Moreover, it increased fluorescence amplitude, maximal rate of rise of fluorescence and reduced time to peak fluorescence. These results suggest that CaMKII in Drosophila melanogaster acts directly on heart function and that increasing CaMKII expression levels could be beneficial to improve contractility. PMID:25003749

  15. Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

    Science.gov (United States)

    Wang, Wei; Chen, Xiao-Long; Zhao, Shen-Yu; Xu, Yu-Hui; Zhang, Wei-Han; Liu, Kai; Chen, Xin-Zu; Yang, Kun; Zhang, Bo; Chen, Zhi-Xin; Chen, Jia-Ping; Zhou, Zong-Guang; Hu, Jian-Kun

    2016-01-01

    The prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma (GC) has been widely reported and is still under debate. Here, we evaluated the prognostic significance of preoperative serum CA125, CA19-9 and CEA in patients with GC. 1692 patients with GC who underwent gastrectomy were divided into the training (from January 2005 to December 2011, n = 1024) and the validation (from January 2012 to December 2013, n = 668) cohorts. Positive groups of CA125 (> 13.72 U/ml), CA19-9 (> 23.36 U/ml) and CEA (> 4.28 ng/ml) were significantly associated with more advanced clinicopathological traits and worse outcomes than that of negative groups (all P < 0.01). In Cox regression analysis, tumor size (P < 0.001, P = 0.005), pTNM stage (P < 0.001, P < 0.001) and CA125 (P = 0.026, P = 0.005) were independent prognostic factors both in two cohorts. Nomograms of these two cohorts based on the number of positive serum tumor markers (NPTM) were more accurate in prognostic prediction than TNM stage alone. Our findings suggested that elevated preoperative serum CA125, CA19-9 and CEA were associated with more advanced clinicopathological traits and less favorable outcomes. In addition, CA125 as an independent prognostic factor should be further investigated. Nomogram based on NPTM could accurately predict the prognosis of GC patients. PMID:27097114

  16. Regulated release of Ca2+ from respiring mitochondria by Ca2+/2H+ antiport.

    Science.gov (United States)

    Fiskum, G; Lehninger, A L

    1979-07-25

    Simultaneous measurements of oxygen consumption and transmembrane transport of Ca2+, H+, and phosphate show that the efflux of Ca2+ from respiring tightly coupled rat liver mitochondria takes place by an electroneutral Ca2+/2H+ antiport process that is ruthenium red-insensitive and that is regulated by the oxidation-reduction state of the mitochondrial pyridine nucleotides. When mitochondrial pyridine nucleotides are kept in a reduced steady state, the efflux of Ca2+ is inhibited; when they are in an oxidized state, Ca2+ efflux is activated. These processes were demonstrated by allowing phosphate-depleted mitochondria respiring on succinate in the presence of rotenone to take up Ca2+ from the medium. Upon subsequent addition of ruthenium red to block Ca2+ transport via the electrophoretic influx pathway, and acetoacetate, to bring mitochondrial pyridine nucleotides into the oxidized state, Ca2+ efflux and H+ influx ensued. The observed H+ influx/Ca2+ efflux ratio was close to the value 2.0 predicted for the operation of an electrically neutral Ca2+/2H+ antiport process.

  17. Ischemic damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3

    DEFF Research Database (Denmark)

    Benveniste, H; Jørgensen, M B; Sandberg, M

    1989-01-01

    The removal of glutamatergic afferents to CA1 by destruction of the CA3 region is known to protect CA1 pyramidal cells against 10 min of transient global ischemia. To investigate further the pathogenetic significance of glutamate, we measured the release of glutamate in intact and CA3-lesioned CA...

  18. EnviroAtlas - Fresno, CA - Block Groups

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas dataset is the base layer for the Fresno, CA EnviroAtlas area. The block groups are from the US Census Bureau and are included/excluded based on...

  19. Role of Ca++ in Shoot Gravitropism. [avena

    Science.gov (United States)

    Rayle, D. L.

    1985-01-01

    A cornerstone in the argument that Ca(2+) levels may regulate growth is the finding the EGTA promotes straight growth. The usual explanation for these results is that Ca(2+) chelation from cell walls results in wall loosening and thus accelerated straight growth. The ability of frozen-thawed Avena coleoptile tissue (subjected to 15g tension) to extend in response to EGTA and Quin II was examined. The EGTA when applied in weakly buffered (i.e., 0.1mM) neutral solutions initiates rapid extension. When the buffer strength is increased, similar concentrations of EGTA produce no growth response. This implies when EGTA liberated protons are released upon Ca(2+) chelation they can either initiate acid growth (low buffer conditions) or if consumed (high buffer conditions) have no effect. Thus Ca(2+) chelation in itself apparently does not result in straight growth.

  20. CaMath user`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Ben-chin; Daly, B.

    1994-07-13

    CaMath is an external Mathematica package which can be loaded into Mathematica by a user. CaMath consists of a special set of channel access functions which provides the Mathematica users with easy and flexible access of channel information across the IOC networks. It also provides a complete set of process variable event monitoring functions. The available functions for CaMath, their functionality, and their syntax are described herein. This document also gives examples how a Mathematica user can interface to channel access devices. It is assumed that the user is already familiar with using Mathematica. Few examples of Mathematica module of using CaMath functions are also given in this document.

  1. Multi-species coral Sr/Ca-based sea-surface temperature reconstruction using Orbicella faveolata and Siderastrea siderea from the Florida Straits

    Science.gov (United States)

    Flannery, Jennifer A.; Richey, Julie N.; Thirumalai, Kaustubh; Poore, Richard Z.; DeLong, Kristine L.

    2017-01-01

    We present new, monthly-resolved Sr/Ca-based sea-surface temperature (SST) records from two species of massive coral, Orbicella faveolata and Siderastrea siderea, from the Dry Tortugas National Park, FL, USA (DTNP). We combine these new records with published data from three additional S. siderea coral colonies to generate a 278-year long multi-species stacked Sr/Ca-SST record from DTNP. The composite record of mean annual Sr/Ca-SST at DTNP shows pronounced decadal-scale variability with a range of 1 to 2°C. Notable cool intervals in the Sr/Ca-derived SST lasting about a decade centered at ~1845, ~1935, and ~1965 are associated with reduced summer Sr/Ca-SST (monthly maxima < 29°C), and imply a reduction in the spatial extent of the Atlantic Warm Pool (AWP). There is significant coherence between the composite DTNP Sr/Ca-SST record and the Atlantic Multidecadal Oscillation (AMO) index, with the AMO lagging Sr/Ca-SST at DTNP by 9 years. Low frequency variability in the Gulf Stream surface transport, which originates near DTNP, may provide a link for the lagged relationship between multidecadal variability at DTNP and the AMO.

  2. CA Investment Casting Process of Complex Castings

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    CA (Computer aided) investment casting technique used in superalloy castings of aerospace engine parts was presented. CA investment casting integrated computer application, RP (Rapid Prototyping) process, solidification simulation and investment casting process. It broke the bottle neck of making metal die. Solid model of complex parts were produced by UGII or other software, then translated into STL(Stereolithography) file, after RP process of SLS(Selective Laser Sintering), wax pattern used in investment ...

  3. YouthCaN 2001 / Sirje Janikson

    Index Scriptorium Estoniae

    Janikson, Sirje

    2001-01-01

    Aprillis 2001 toimus keskkonnateemaline õpilaskonverents YouthCaN 2001 Ameerika Loodusajaloo Muuseumis New Yorkìs. 35 seminarist ühe viis läbi Tartu Noorte Loodusmaja geoloogia ja keskkonnaringi esindus, tutvustati loodusmaja keskkonnaprojekte ja räägiti keskkonnaalaste veebilehtede koostamise kogemustest. YouthCaN (Youth Communicating and Networking) on rahvusvaheline noorte organisatsioon, mis vahendab kogemusi ja uusi ideid elukeskkonnast huvitatud noorte hulgas

  4. YouthCaN 2001 / Sirje Janikson

    Index Scriptorium Estoniae

    Janikson, Sirje

    2001-01-01

    Aprillis 2001 toimus keskkonnateemaline õpilaskonverents YouthCaN 2001 Ameerika Loodusajaloo Muuseumis New Yorkìs. 35 seminarist ühe viis läbi Tartu Noorte Loodusmaja geoloogia ja keskkonnaringi esindus, tutvustati loodusmaja keskkonnaprojekte ja räägiti keskkonnaalaste veebilehtede koostamise kogemustest. YouthCaN (Youth Communicating and Networking) on rahvusvaheline noorte organisatsioon, mis vahendab kogemusi ja uusi ideid elukeskkonnast huvitatud noorte hulgas

  5. Mitochondrial Ca2+ uptake in skeletal muscle health and disease

    CERN Document Server

    Zhou, Jingsong; Yi, Jianxun

    2016-01-01

    Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2+ from their surroundings, a process called mitochondrial Ca2+ uptake. Under physiological conditions, Ca2+ uptake into mitochondria promotes ATP production. Excessive uptake causes mitochondrial Ca2+ overload, which activates downstream adverse responses leading to cell dysfunction. Moreover, mitochondrial Ca2+ uptake could shape spatio-temporal patterns of intracellular Ca2+ signaling. Malfunction of mitochondrial Ca2+ uptake is implicated in muscle degeneration. Unlike non-excitable cells, mitochondria in muscle cells experience dramatic changes of intracellular Ca2+ levels. Besides the sudden elevation of Ca2+ level induced by action potentials, Ca2+ transients in muscle cells can be as short as a few milliseconds during a single twitch or as long as min...

  6. PIK3CA in colorectal cancer

    Directory of Open Access Journals (Sweden)

    Gieri eCathomas

    2014-03-01

    Full Text Available PIK3CA, the catalytic subunit of PI3K, is mutated in many different tumours, including colorectal cancer. Mutations of PIK3CA have been reported in 10 – 20% of colorectal cancer, about 80% of mutations found in two hot spots in exon 9 and exon 20. In RAS wild-type colorectal cancers, PIK3CA mutations have been associated with a worse clinical outcome and with a negative prediction of a response to targeted therapy by anti-EGFR monoclonal antibodies. However, these findings have not been confirmed in all studies and subsequent more detailed analysis has revealed that these effects may be restricted to mutations in Exon 20. Finally, mutations in PIK3CA may be the long sought biomarker for successful adjuvant therapy with aspirin in patients with colorectal cancer. Therefore, PIK3CA mutations appear to be a promising predictive biomarker; however, further data are needed to conclusively define the impact of somatic mutations in the PIK3CA gene for the management of patients with colorectal cancer.

  7. X-Ray Data on Extraterrestrial CA Dialuminate (CaAl4O7)

    Science.gov (United States)

    Weber, D.; Ross, C. R., II; Bischoff, A.

    1993-07-01

    After the first discovery of Ca-dialuminate (CaAl4O7) in Allende [1], in recent years this phase has been found in several carbonaceous chondrites. Ca- dialuminate is a major phase in Ca,Al-rich inclusions from ALH85085 (e.g., [2]) and a dominating phase in CAIs from Acfer 182 ([3,4]). X-ray data on Ca-dialuminate are known from synthetic (e.g., [5-8]; cell constants) and terrestrial CaAl4O7 ([9]; only d-spacings), but are not available from extraterrestrial Ca-dialuminate. We report here the results of the first X-ray study of extraterrestrial Ca- dialuminate. The data (Table 1) were obtained by microdiffraction using a Rigaku PSPC microdiffractometer at the Bayerisches Geoinstitut. Ni-filtered Cr radiation was used with a direct beam diameter of about 50 micrometers. This powder diffraction method allows in situ measurement of polycrystalline Ca- dialuminate in a thin section. The CaAl4O7-rich inclusion 022/9 described in [4], consisting of a ~200-micrometer-sized core of Ca-dialuminate surrounded by layers of melilite and Ca-pyroxene, was chosen for analysis. The polycrystalline core contains only a small number of tiny inclusions (especially perovskite) and is therefore an excellent candidate for an X-ray study. For determination of the d-spacings of Ca-dialuminate an external standard (Ag6Ge10P12) was used for detector calibration. A large number of reflections could be indexed based upon comparison with the X-ray pattern of synthetic CaAl4O7 available in the JCPDS compilation [7]. The comparison was simplified because of the high purity of CaAl4O7 in inclusion 022/9 [4], and suggests the same structure for synthetic and extraterrestrial Ca-dialuminate. For determination of lattice parameters (cell constants, cell volume) refinement calculations were made based on 14 reflections (Table 1). The data for extraterrestrial CaAl4O7 shown in Table 1 indicate a close similarity to those obtained for synthetic CaAl4O7. The cell constants a, b, and therefore the cell

  8. Ultrastructural and immunohistochemical localization of plasma membrane Ca2+-ATPase 4 in Ca2+-transporting epithelia

    DEFF Research Database (Denmark)

    Alexander, R Todd; Beggs, Megan R; Zamani, Reza

    2015-01-01

    Plasma Membrane Ca(2+)-ATPase's (PMCA) participate in epithelial Ca(2+) transport and intracellular Ca(2+) signaling. The Pmca4 isoform is enriched in distal nephron isolates and decreased in mice lacking the epithelial Ca(2+) channel, Trpv5. We therefore hypothesized that Pmca4 plays a significant...... in distal nephron cells at both the basolateral membrane and intracellular perinuclear compartments, but not submembranous vesicles, suggesting rapid trafficking to the plasma membrane is unlikely to occur in vivo. Pmca4 expression was not altered by perturbations in Ca(2+) balance, pointing...... detected Pmca1 in lateral membranes of enterocytes. In kidney, Pmca4 showed broad localization to the distal nephron. In mouse, expression was most abundant in segments coexpressing the epithelial Ca(2+) channel, Trpv5. Significant, albeit lower expression, was also evident in the region encompassing...

  9. Sarcolemmal Ca(2+)-entry through L-type Ca(2+) channels controls the profile of Ca(2+)-activated Cl(-) current in canine ventricular myocytes.

    Science.gov (United States)

    Horváth, Balázs; Váczi, Krisztina; Hegyi, Bence; Gönczi, Mónika; Dienes, Beatrix; Kistamás, Kornél; Bányász, Tamás; Magyar, János; Baczkó, István; Varró, András; Seprényi, György; Csernoch, László; Nánási, Péter P; Szentandrássy, Norbert

    2016-08-01

    Ca(2+)-activated Cl(-) current (ICl(Ca)) mediated by TMEM16A and/or Bestrophin-3 may contribute to cardiac arrhythmias. The true profile of ICl(Ca) during an actual ventricular action potential (AP), however, is poorly understood. We aimed to study the profile of ICl(Ca) systematically under physiological conditions (normal Ca(2+) cycling and AP voltage-clamp) as well as in conditions designed to change [Ca(2+)]i. The expression of TMEM16A and/or Bestrophin-3 in canine and human left ventricular myocytes was examined. The possible spatial distribution of these proteins and their co-localization with Cav1.2 was also studied. The profile of ICl(Ca), identified as a 9-anthracene carboxylic acid-sensitive current under AP voltage-clamp conditions, contained an early fast outward and a late inward component, overlapping early and terminal repolarizations, respectively. Both components were moderately reduced by ryanodine, while fully abolished by BAPTA, but not EGTA. [Ca(2+)]i was monitored using Fura-2-AM. Setting [Ca(2+)]i to the systolic level measured in the bulk cytoplasm (1.1μM) decreased ICl(Ca), while application of Bay K8644, isoproterenol, and faster stimulation rates increased the amplitude of ICl(Ca). Ca(2+)-entry through L-type Ca(2+) channels was essential for activation of ICl(Ca). TMEM16A and Bestrophin-3 showed strong co-localization with one another and also with Cav1.2 channels, when assessed using immunolabeling and confocal microscopy in both canine myocytes and human ventricular myocardium. Activation of ICl(Ca) in canine ventricular cells requires Ca(2+)-entry through neighboring L-type Ca(2+) channels and is only augmented by SR Ca(2+)-release. Substantial activation of ICl(Ca) requires high Ca(2+) concentration in the dyadic clefts which can be effectively buffered by BAPTA, but not EGTA.

  10. Endothelin-1 induces intracellular [Ca2+] increase via Ca2+ influx through the L-type Ca2+ channel, Ca2+-induced Ca2+ release and a pathway involving ETA receptors, PKC, PKA and AT1 receptors in cardiomyocytes

    Institute of Scientific and Technical Information of China (English)

    ZENG QingHua; LI XingTing; ZHONG GuoGan; ZHANG WenJie; SUN ChengWen

    2009-01-01

    Using fura-2-acetoxymethyl eater (AM) fluorescence imaging and patch clamp techniques, we found that endothelin-1 (ET-1) significantly elevated the intracellular calcium level ([Ca2+]1) in a dose-dependent manner and activated the L-type Ca2+ channel in cardiomyocytes isolated from rats.The effect of ET-1 on [Ca2+]1 elevation was abolished in the presence of the ETA receptor blocker BQ123,but was not affected by the ETa receptor blocker BQ788. ET-1-induced an increase in [Ca2+]1, which was inhibited 46.7% by pretreatment with a high concentration of ryanodine (10 μmol/L), a blocker of the ryanodine receptor. The ET-1-induced [Ca2+]i increase was also inhibited by the inhibltors of protein kinase A (PKA), protein kinase C (PKC) and angiotensin type 1 receptor (AT1 receptor). We found that ET-1 induced an enhancement of the amplitude of the whole cell L-type Ca2+ channel current and an Increase of open-state probability (NPo) of an L-type single Ca2+ channel. BQ123 completely blocked the ET-1-induced increase in calcium channel open-state probability. In this study we demonstrated that ET-1 regulates calcium overload through a series of mechanisms that include L-type Ca2+ channel activation and Ca2+-induced Ca2+ release (CICR). ETa receptors, PKC, PKA and AT1 receptors may also contribute to this pathway.

  11. Endothelin-1 induces intracellular [Ca2+] increase via Ca2+ influx through the L-type Ca2+ channel, Ca2+-induced Ca2+ release and a pathway involving ETA receptors, PKC, PKA and AT1 receptors in cardiomyocytes

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Using fura-2-acetoxymethyl ester (AM) fluorescence imaging and patch clamp techniques, we found that endothelin-1 (ET-1) significantly elevated the intracellular calcium level ([Ca2+]i) in a dose-dependent manner and activated the L-type Ca2+ channel in cardiomyocytes isolated from rats. The effect of ET-1 on [Ca2+]i elevation was abolished in the presence of the ETA receptor blocker BQ123, but was not affected by the ETB receptor blocker BQ788. ET-1-induced an increase in [Ca2+]i, which was inhibited 46.7% by pretreatment with a high concentration of ryanodine (10 μmol/L), a blocker of the ryanodine receptor. The ET-1-induced [Ca2+]i increase was also inhibited by the inhibitors of protein kinase A (PKA), protein kinase C (PKC) and angiotensin type 1 receptor (AT1 receptor). We found that ET-1 induced an enhancement of the amplitude of the whole cell L-type Ca2+ channel current and an increase of open-state probability (NPo) of an L-type single Ca2+ channel. BQ123 completely blocked the ET-1-induced increase in calcium channel open-state probability. In this study we demonstrated that ET-1 regulates calcium overload through a series of mechanisms that include L-type Ca2+ channel activation and Ca2+-induced Ca2+ release (CICR). ETA receptors, PKC, PKA and AT1 receptors may also contribute to this pathway.

  12. TOURISM IN THE USA – CONTEMPORARY STATE, TENDENCIES, PROBLEMS

    Directory of Open Access Journals (Sweden)

    Krasimir Levkov

    2015-03-01

    Full Text Available The article presents the contemporary state of travel and tourism and shows the profile of one of the biggest industries in the USA that has an important economic and social impact. The tendencies in the development of the tourism infrastructure and in the structure of tourist flows (separately about the outbound, inbound and domestic tourism are analyzed. Some regional and functional characteristics in the development of the American tourism are highlighted. The problem of the insufficient tourism openness of the USA and the approaches to its increase are analyzed.

  13. Ca(2+-dependent regulation of the Ca(2+ concentration in the myometrium mitochondria. II. Ca(2+ effects on mitochondria membranes polarization and [Ca(2+](m

    Directory of Open Access Journals (Sweden)

    L. G. Babich

    2017-06-01

    Full Text Available It is known that Ca2+ accumulation in the mitochondria undergoes complex regulation by Ca2+ itself. But the mechanisms of such regulation are still discussed. In this paper we have shown that Ca ions directly or indirectly regulate the level of myometrium mitochondria membranes polarization. The additions of 100 µM Ca2+ were accompanied by depolarization of the mitochondria membranes. The following experiments were designed to study the impact of Ca2+ on the myometrium mitochondria [Ca2+]m. Isolated myometrium mitochondria were preincubated without or with 10 μM Са2+ followed by 100 μM Са2+ addition. Experiments were conducted in three mediums: without ATP and Mg2+ (0-medium, in the presence of 3 mM Mg2+ (Mg-medium and 3 mM Mg2+ + 3 mM ATP (Mg,ATP-medium. It was shown that the effects of 10 μM Са2+ addition were different in different mediums, namely in 0- and Mg-medium the [Ca2+]m values increased, whereas in Mg,ATP-medium statistically reliable changes were not registered. Preincubation of mitochondria with 10 μM Са2+ did not affect the [Ca2+]m value after the addition of 100 μM Са2+. The [Ca2+]m values after 100 μM Са2+ addition were the same in 0- and Mg,ATP-mediums and somewhat lower in Mg-medium. Preliminary incubation of mitochondria with 10 μM Са2+ in 0- and Mg-mediums reduced changes of Fluo 4 normalized fluorescence values that were induced by 100 μM Са2+ additions, but in Mg,ATP-medium such differences were not recorded. It is concluded that Са2+ exchange in myometrium mitochondria is regulated by the concentration of Ca ions as in the external medium, so in the matrix of mitochondria. The medium composition had a significant impact on the [Са2+]m values in the absence of exogenous cation. It is suggested that light increase of [Са2+]m before the addition of 100 μM Са2+ may have a positive effect on the functional activity of the mitochondria.

  14. Physical conditions in CaFe interstellar clouds

    CERN Document Server

    Gnacinski, P

    2007-01-01

    Interstellar clouds that exhibit strong Ca I and Fe I lines were called CaFe clouds. The ionisation equilibrium equations were used to model the column densities of Ca II, Ca I, K I, Na I, Fe I and Ti II in CaFe clouds. The chemical composition of CaFe clouds is that of the Solar System and no depletion of elements onto dust grains is seen. The CaFe clouds have high electron densities n=1 cm^-3 that leads to high column densities of neutral Ca and Fe.

  15. Physical conditions in CaFe interstellar clouds

    OpenAIRE

    Gnacinski, P.; Krogulec, M.

    2007-01-01

    Interstellar clouds that exhibit strong Ca I and Fe I lines were called CaFe clouds. The ionisation equilibrium equations were used to model the column densities of Ca II, Ca I, K I, Na I, Fe I and Ti II in CaFe clouds. The chemical composition of CaFe clouds is that of the Solar System and no depletion of elements onto dust grains is seen. The CaFe clouds have high electron densities n=1 cm^-3 that leads to high column densities of neutral Ca and Fe.

  16. Mitochondrial calcium uniporter MCU supports cytoplasmic Ca2+ oscillations, store-operated Ca2+ entry and Ca2+-dependent gene expression in response to receptor stimulation.

    Directory of Open Access Journals (Sweden)

    Krishna Samanta

    Full Text Available Ca2+ flux into mitochondria is an important regulator of cytoplasmic Ca2+ signals, energy production and cell death pathways. Ca2+ uptake can occur through the recently discovered mitochondrial uniporter channel (MCU but whether the MCU is involved in shaping Ca2+ signals and downstream responses to physiological levels of receptor stimulation is unknown. Here, we show that modest stimulation of leukotriene receptors with the pro-inflammatory signal LTC4 evokes a series of cytoplasmic Ca2+ oscillations that are rapidly and faithfully propagated into mitochondrial matrix. Knockdown of MCU or mitochondrial depolarisation, to reduce the driving force for Ca2+ entry into the matrix, prevents the mitochondrial Ca2+ rise and accelerates run down of the oscillations. The loss of cytoplasmic Ca2+ oscillations appeared to be a consequence of enhanced Ca2+-dependent inactivation of InsP3 receptors, which arose from the loss of mitochondrial Ca2+ buffering. Ca2+ dependent gene expression in response to leukotriene receptor activation was suppressed following knockdown of the MCU. In addition to buffering Ca2+ release, mitochondria also sequestrated Ca2+ entry through store-operated Ca2+ channels and this too was prevented following loss of MCU. MCU is therefore an important regulator of physiological pulses of cytoplasmic Ca2+.

  17. Mitochondrial calcium uniporter MCU supports cytoplasmic Ca2+ oscillations, store-operated Ca2+ entry and Ca2+-dependent gene expression in response to receptor stimulation.

    Science.gov (United States)

    Samanta, Krishna; Douglas, Sophie; Parekh, Anant B

    2014-01-01

    Ca2+ flux into mitochondria is an important regulator of cytoplasmic Ca2+ signals, energy production and cell death pathways. Ca2+ uptake can occur through the recently discovered mitochondrial uniporter channel (MCU) but whether the MCU is involved in shaping Ca2+ signals and downstream responses to physiological levels of receptor stimulation is unknown. Here, we show that modest stimulation of leukotriene receptors with the pro-inflammatory signal LTC4 evokes a series of cytoplasmic Ca2+ oscillations that are rapidly and faithfully propagated into mitochondrial matrix. Knockdown of MCU or mitochondrial depolarisation, to reduce the driving force for Ca2+ entry into the matrix, prevents the mitochondrial Ca2+ rise and accelerates run down of the oscillations. The loss of cytoplasmic Ca2+ oscillations appeared to be a consequence of enhanced Ca2+-dependent inactivation of InsP3 receptors, which arose from the loss of mitochondrial Ca2+ buffering. Ca2+ dependent gene expression in response to leukotriene receptor activation was suppressed following knockdown of the MCU. In addition to buffering Ca2+ release, mitochondria also sequestrated Ca2+ entry through store-operated Ca2+ channels and this too was prevented following loss of MCU. MCU is therefore an important regulator of physiological pulses of cytoplasmic Ca2+.

  18. Relationship Between Ca2+-CaM and Ethylene-Induced PG Activity in Tomato Fruit

    Institute of Scientific and Technical Information of China (English)

    GU Cai-qin; XI Yu-fang; GUAN Jun-feng; LI Guang-min

    2003-01-01

    Polygalacturonase (PG) was studied during ripening and senescence of postharvest tomatofruit at pink stage at low and normal temperature. The results showed that the PG activity increased, thendecreased during ripening and senescence of tomato. Low temperature inhibited but ethylene enhanced PGactivity. Ethylene also enhanced caimodulin content, which was dependent on Ca2+ concentration in cell.When EGTA(Ca2+ chelator), verapamil (Vp) and LaCl3 (Ca2+ channel blockers), trifluoperazine and chloro-promaize (two CaM antagonisms) were used to treat tomato fruit at green mature stage with ethylene, theycould reverse ethylene-induced increase in PG activity, but Vp, chloropromaize (CPZ), trifluoperazine(TFP) could not directly influence PG activity, which indirectly indicated that influx of Ca2+ from the ex-tracellular space including the cell wall via the Ca2+ channel localized in plasma membrane and CaM were re-quired for ethylene-induced PG activity increase and that ethylene signal transduction may be related to Ca2+- CaM messenger system.

  19. Negative feedback from CaSR signaling to aquaporin-2 sensitizes vasopressin to extracellular Ca2.

    Science.gov (United States)

    Ranieri, Marianna; Tamma, Grazia; Di Mise, Annarita; Russo, Annamaria; Centrone, Mariangela; Svelto, Maria; Calamita, Giuseppe; Valenti, Giovanna

    2015-07-01

    We previously described that high luminal Ca(2+) in the renal collecting duct attenuates short-term vasopressin-induced aquaporin-2 (AQP2) trafficking through activation of the Ca(2+)-sensing receptor (CaSR). Here, we evaluated AQP2 phosphorylation and permeability, in both renal HEK-293 cells and in the dissected inner medullary collecting duct, in response to specific activation of CaSR with NPS-R568. In CaSR-transfected cells, CaSR activation drastically reduced the basal levels of AQP2 phosphorylation at S256 (AQP2-pS256), thus having an opposite effect to vasopressin action. When forskolin stimulation was performed in the presence of NPS-R568, the increase in AQP2-pS256 and in the osmotic water permeability were prevented. In the freshly isolated inner mouse medullar collecting duct, stimulation with forskolin in the presence of NPS-R568 prevented the increase in AQP2-pS256 and osmotic water permeability. Our data demonstrate that the activation of CaSR in the collecting duct prevents the cAMP-dependent increase in AQP2-pS256 and water permeability, counteracting the short-term vasopressin response. By extension, our results suggest the attractive concept that CaSR expressed in distinct nephron segments exerts a negative feedback on hormones acting through cAMP, conferring high sensitivity of hormone to extracellular Ca(2+). © 2015. Published by The Company of Biologists Ltd.

  20. Heat and hyposmotic stimulation increase in [Ca2+]i by Ca2+ influx in rat synoviocytes

    Institute of Scientific and Technical Information of China (English)

    SUN WenWu; HU Fen; YANG WenXiu

    2008-01-01

    Rheumatoid arthritis (RA), which is marked by inflammatory synovitis, is a common, chronic autoimmune-disease, whose pathogenesis is complex and still unclear. In order to explore the effects of heat and hyposmotic stimuli on synoviocytes in rheumatoid arthritis, the changes of [Ca2+]i induced by heat, hyposmotic and 4α-PDD stimuli were observed in synoviocytes. [Ca2+]i elevation induced by heat ≥ 28℃, hyposmotic and 4α-PDD stimuli is found to be positively relative to increasing temperature, decreasing osmolality and rising concentration of 4α-PDD. Results show that there is reciprocity among these stimuli and desensitization, and that [Ca2+]i elevation depends on Ca2+ influx, but not necessarily links to Ca2+ release from intracellular stores and voltage-dependent Ca2+ channel in synoviocytes. The above characteristics of Ca2+ influx are similar to those of TRPV4. A probable mechanism has been suggested that heat and hyposmotic stimulation might increase the level of [Ca2+]i by activating the TRPV4-like channel and Ca2+ influx in the synoviocytes.

  1. CaCl2-CaO熔盐中金属钙的电沉积行为研究

    Institute of Scientific and Technical Information of China (English)

    郭君康

    2014-01-01

    在900℃下,采用循环伏安法对CaCl2-CaO熔盐中金属钙的电沉积行为进行了研究.研究结果表明,在CaCl2熔盐中加入CaO后,熔盐中Ca2+的还原电位正移,且Ca2+的还原过程受扩散控制.

  2. Effects of inhaled anesthetic isoflurane on long-term potentiation of CA3 pyramidal cell afferents in vivo

    Directory of Open Access Journals (Sweden)

    Ballesteros KA

    2012-11-01

    Full Text Available Kristen A Ballesteros,1 Angela Sikorski,2 James E Orfila,3 Joe L Martinez Jr41Department of Biology, The University of Texas at San Antonio, San Antonio, TX, USA; 2Texas A&M University Texarkana, Texarkana, TX, USA; 3University of Colorado in Denver, Denver, CO, USA; 4University of Illinois in Chicago, Chicago, IL, USAAbstract: Isoflurane is a preferred anesthetic, due to its properties that allow a precise concentration to be delivered continually during in vivo experimentation. The major mechanism of action of isoflurane is modulation of the γ-amino butyric acid (GABAA receptor-chloride channel, mediating inhibitory synaptic transmission. Animal studies have shown that isoflurane does not cause cell death, but it does inhibit cell growth and causes long-term hippocampal learning deficits. As there are no studies characterizing the effects of isoflurane on electrophysiological aspects of long-term potentiation (LTP in the hippocampus, it is important to determine whether isoflurane alters the characteristic responses of hippocampal afferents to cornu ammonis region 3 (CA3. We investigated the effects of isoflurane on adult male rats during in vivo induction of LTP, using the mossy fiber pathway, the lateral perforant pathway, the medial perforant pathway, and the commissural CA3 (cCA3 to CA3, with intracranial administration of Ringer’s solution, naloxone, RS-aminoindan-1, 5-dicarboxylic acid (AIDA, or 3-[(R-2-carboxypiperazin-4-yl]-propo-2-enyl-1-phosphonic acid (CPP. Then, we compared these responses to published electrophysiological data, using sodium pentobarbital as an anesthetic, under similar experimental conditions. Our results showed that LTP was exhibited in animals anesthetized with isoflurane under vehicle conditions. With the exception of AIDA in the lateral perforant pathway, the defining characteristics of the four pathways appeared to remain intact, except for the observation that LTP was markedly reduced in animals

  3. Functional expression of Na-Ca exchanger clones measured with the fluorescent Ca(2+)-indicating dye fluo-3.

    Science.gov (United States)

    Schnetkamp, P P

    1996-01-01

    The process of Ca2+ homeostasis is of prime importance to all cells because of the ubiquitous role of cytoplasmic Ca2+ as an intracellular messenger and the cytotoxicity of sustained elevated cytosolic Ca2+ concentrations. Two classes of plasma membrane proteins are responsible for maintaining cytosolic free Ca2+ in the submicromolar range against a very large electrochemical Ca2+ gradient across the plasma membrane, the ATP-driven Ca2+ pump and Na-Ca exchangers. Two types of Na-Ca exchangers are known, the 3Na:1Ca exchangers found in heart, brain, kidney, and most other tissues and the 4Na:1Ca+ 1K exchanger found in retinal rod and cone photoreceptors. Functional expression of Na-Ca(/K) exchangers is most often measured as 45Ca uptake in Na(+)-loaded cells or as Na-Ca exchange currents with the giant excised patch technique. In this study, two functional assays used to detect expression of the bovine heart Na-Ca exchanger in CHO cells are described. Both assays are based on measurements of cytosolic free Ca2+ with the fluorescent Ca(2+)-indicating dye fluo-3 and should be equally applicable in the study of functional expression of both Na-Ca and Na-Ca/K exchanger clones.

  4. CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency dependent acceleration of relaxation and Ca2+ current facilitation

    OpenAIRE

    Picht, Eckard; DeSantiago, Jaime; Huke, Sabine; Kaetzel, Marcia A.; Dedman, John R.; Bers, Donald M.

    2006-01-01

    Cardiac Ca2+/calmodulin-dependent protein kinase II (CaMKII) in heart has been implicated in Ca2+ current (ICa) facilitation, enhanced sarcoplasmic reticulum (SR) Ca2+ release and frequency dependent acceleration of relaxation (FDAR) via enhanced SR Ca2+ uptake. However, questions remain about how CaMKII may work in these three processes. Here we tested the role of CaM-KII in these processes using transgenic mice (SR-AIP) that express four concatenated repeats of the CaMKII inhibitory peptide...

  5. Copper bioavailability and toxicity to Mytilus galloprovincialis in Shelter Island Yacht Basin, San Diego, CA.

    Science.gov (United States)

    Bosse, Casey; Rosen, Gunther; Colvin, Marienne; Earley, Patrick; Santore, Robert; Rivera-Duarte, Ignacio

    2014-08-15

    The bioavailability and toxicity of copper (Cu) in Shelter Island Yacht Basin (SIYB), San Diego, CA, USA, was assessed with simultaneous toxicological, chemical, and modeling approaches. Toxicological measurements included laboratory toxicity testing with Mytilus galloprovincialis (Mediterranean mussel) embryos added to both site water (ambient) and site water spiked with multiple Cu concentrations. Chemical assessment of ambient samples included total and dissolved Cu concentrations, and Cu complexation capacity measurements. Modeling was based on chemical speciation and predictions of bioavailability and toxicity using a marine Biotic Ligand Model (BLM). Cumulatively, these methods assessed the natural buffering capacity of Cu in SIYB during singular wet and dry season sampling events. Overall, the three approaches suggested negligible bioavailability, and isolated observed or predicted toxicity, despite an observed gradient of increasing Cu concentration, both horizontally and vertically within the water body, exceeding current water quality criteria for saltwater. Published by Elsevier Ltd.

  6. Causes of sinks near Tucson, Arizona, USA

    Science.gov (United States)

    Hoffmann, John P.; Pool, Donald R.; Konieczki, A. D.; Carpenter, Michael C.

    Land subsidence in the form of sinks has occurred on and near farmlands near Tucson, Pima County, Arizona, USA. The sinks occur in alluvial deposits along the flood plain of the Santa Cruz River, and have made farmlands dangerous and unsuitable for farming. More than 1700 sinks are confined to the flood plain of the Santa Cruz River and are grouped along two north-northwestward-trending bands that are approximately parallel to the river and other flood-plain drainages. An estimated 17,000m3 of sediment have been removed in the formation of the sinks. Thirteen trenches were dug to depths of 4-6m to characterize near-surface sediments in sink and nonsink areas. Sediments below about 2m included a large percentage of dispersive clays in sink areas. Sediments in nonsink areas contain a large component of medium- to coarse-grained, moderately to well sorted sand that probably fills a paleochannel. Electromagnetic surveys support the association of silts and clays in sink areas that are highly electrically conductive relative to sand in nonsink areas. Sinks probably are caused by the near-surface process of subsurface erosion of dispersive sediments along pre-existing cracks in predominantly silt and clay sediments. The pre-existing cracks probably result from desiccation or tension that developed during periods of water-table decline and channel incision during the past 100 years or in earlier periods. Résumé Des effondrements en forme d'entonnoir se sont produits sur et près d'exploitations agricoles de Pima (Arizona). Ces entonnoirs apparaissent dans les alluvions le long de la plaine d'inondation de la rivière Santa Cruz ; ils ont rendu ces terrains dangereux et inexploitables pour l'agriculture. Plus de 1700 entonnoirs existent dans la plaine d'inondation de la rivière Santa Cruz et sont groupés en deux bandes orientées nord-nord-ouest, approximativement parallèles à la rivière et aux autres chenaux de la plaine d'inondation. Un volume de sédiments estim

  7. Treatment of Ruptured Ovarian Endometrioma with Extremely High CA 125, Moderately High CA 19-9 and CA 15-3 Level

    Directory of Open Access Journals (Sweden)

    Muzeyyen Duran

    2013-06-01

    Full Text Available In this case report, a ruptured ovarian endometrioma with a very high CA-125 level, moderately elevated CA 19-9, and CA 15-3 levels is presented. A 20 years old patient, complaining from pelvic pain, 5 cm adnexial mass was detected on left side. Biochemical examination was revealed very high CA-125 value (2556IU/ml, moderately elevated CA 19-9 (134IU/ml, and CA 15-3 (65IU/ml values. Laparoscopy was done and a ruptured ovarian endometrioma of 5 cm was seen during operation. After the total excision of the cyst, tumor markers fell rapidly. Very high CA-125 value, moderately elevated CA19-9, and CA 15-3 values can be seen in cases with ruptured endometrioma. In young patients, endometrioma must be considered firstly and laparoscopy should be applied instead of more invasive methods unless there was any finding or strong suspicion about malignancy.

  8. A significant but rather mild contribution of T286 autophosphorylation to Ca2+/CaM-stimulated CaMKII activity.

    Directory of Open Access Journals (Sweden)

    Steven J Coultrap

    Full Text Available BACKGROUND: Autophosphorylation of the Ca(2+/calmodulin (CaM-dependent protein kinase II (CaMKII at T286 generates partially Ca(2+/CaM-independent "autonomous" activity, which is thought to be required for long-term potentiation (LTP, a form of synaptic plasticity thought to underlie learning and memory. A requirement for T286 autophosphorylation also for efficient Ca(2+/CaM-stimulated CaMKII activity has been described, but remains controversial. METHODOLOGY/PRINCIPAL FINDINGS: In order to determine the contribution of T286 autophosphorylation to Ca(2+/CaM-stimulated CaMKII activity, the activity of CaMKII wild type and its phosphorylation-incompetent T286A mutant was compared. As the absolute activity can vary between individual kinase preparations, the activity was measured in six different extracts for each kinase (expressed in HEK-293 cells. Consistent with measurements on purified kinase (from a baculovirus/Sf9 cell expression system, CaMKII T286A showed a mildly but significantly reduced rate of Ca(2+/CaM-stimulated phosphorylation for two different peptide substrates (to ~75-84% of wild type. Additional slower CaMKII autophosphorylation at T305/306 inhibits stimulation by Ca(2+/CaM, but occurs only minimally for CaMKII wild type during CaM-stimulated activity assays. Thus, we tested if the T286A mutant may show more extensive inhibitory autophosphorylation, which could explain its reduced stimulated activity. By contrast, inhibitory autophosphorylation was instead found to be even further reduced for the T286A mutant under our assay conditions. On a side note, the phospho-T305 antibody showed some basal background immuno-reactivity also with non-phosphorylated CaMKII, as indicated by T305/306A mutants. CONCLUSIONS/SIGNIFICANCE: These results indicate that Ca(2+/CaM-stimulated CaMKII activity is mildly (~1.2-1.3fold further increased by additional T286 autophosphorylation, but that this autophosphorylation is not required for the major

  9. Alar Laneman siirdub USA-sse kaitseatašeeks / Holger Roonemaa

    Index Scriptorium Estoniae

    Roonemaa, Holger

    2007-01-01

    Brigaadikindral Alar Lanemanist võib saada Eesti kaitseatašee USA-s. Endise kaitseministri Jürgen Ligi sõnul oli A. Laneman osaline mitmetes juhtimisvigades ning neist ühe puhul kestab senini kriminaalasi

  10. Alar Laneman siirdub USA-sse kaitseatašeeks / Holger Roonemaa

    Index Scriptorium Estoniae

    Roonemaa, Holger

    2007-01-01

    Brigaadikindral Alar Lanemanist võib saada Eesti kaitseatašee USA-s. Endise kaitseministri Jürgen Ligi sõnul oli A. Laneman osaline mitmetes juhtimisvigades ning neist ühe puhul kestab senini kriminaalasi

  11. "Disko ja tuumasõda" jõuab USA-sse

    Index Scriptorium Estoniae

    2010-01-01

    Jaak Kilmi ja Kiur Aarma dokumentaalfilm "Disko ja tuumasõda" hakkab alates 12. novembrist jooksma New Yorgi kinos Cinema Village. 26. novembrist saab filmi näha Los Angeleses. Filmi levitaja USA-s on Icarus Film

  12. Transboundary aquifers along the Canada–USA border: Science, policy and social issues

    National Research Council Canada - National Science Library

    Rivera, Alfonso

    2015-01-01

    Study region: Canada–USA border. Study focus: Since 2005, Canada has followed international developments in transboundary groundwater issues in cooperation with its southern neighbor the United States (USA...

  13. USA kongresmen Chandler - sõber, kes aitas Eestil tunnustust leida / Eric A. Johnson, Oliver Prits

    Index Scriptorium Estoniae

    Johnson, Eric A.

    2008-01-01

    Advokaadi ja USA kongressi liikme Walter M. Chandleri (1867-1935) tegevusest Balti riikide de jure tunnustamiseks. Lisatud: USA valitsuse avaldus Balti riikide tunnustamisest ; väike elulugu : Jeesuse advokaat

  14. USA finantskriis tabas Eestit eriti halval ajal / Lemmi Kann, Kaisa Tahlfeld

    Index Scriptorium Estoniae

    Kann, Lemmi

    2008-01-01

    USA-s puhkenud finantskriis ja Euroopa jahenev majanduskliima takistab Eesti majanduse taastumist. Küsimustele vastab Eesti Panga asepresident Andres Sutt. Kommenteerivad Aare Järvan ja Rain Tamm. Diagramm: Dow Jonesi ja OMXT indeksite muutus

  15. 78 FR 5500 - Manufacturer of Controlled Substances, Notice of Application; Siegfried (USA)

    Science.gov (United States)

    2013-01-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances, Notice of Application; Siegfried (USA... 19, 2012, Siegfried (USA), 33 Industrial Park Road, Pennsville, New Jersey 08070, made application...

  16. 78 FR 46613 - Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC

    Science.gov (United States)

    2013-08-01

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC... 10, 2013, Siegfried (USA), LLC., 33 Industrial Park Road, Pennsville, New Jersey 08070,...

  17. USA kongresmen Chandler - sõber, kes aitas Eestil tunnustust leida / Eric A. Johnson, Oliver Prits

    Index Scriptorium Estoniae

    Johnson, Eric A.

    2008-01-01

    Advokaadi ja USA kongressi liikme Walter M. Chandleri (1867-1935) tegevusest Balti riikide de jure tunnustamiseks. Lisatud: USA valitsuse avaldus Balti riikide tunnustamisest ; väike elulugu : Jeesuse advokaat

  18. USA rahatrükkimine tõstab ka Eestis hindu / Adele Pao

    Index Scriptorium Estoniae

    Pao, Adele

    2010-01-01

    USA Keskpanga otsus majanduse turgutamiseks lisaraha trükkida annab analüütikute hinnangul Eestis tunda eelkõige hinnatõusuna. USA keskpanga otsuse mõjust Saksamaa, Brasiilia, Hiina ja arenevate riikide majandusele

  19. National Assessment of Tree City USA Participation According to Geography and Socioeconomic Characteristics

    Science.gov (United States)

    Tree City USA is a national program that recognizes municipal commitment to community forestry. In return for meeting program requirements, Tree City USA participants expect social, economic, and/or environmental benefits. Understandingthe geographic distribution and socioeconomi...

  20. Child Health USA 2013: Postpartum Visit and Well-Baby Care

    Science.gov (United States)

    ... HRSA MCHB CHUSA Downloads Viewers & Players Child Health USA 2013 An illustrated collection of current and historical ... found in the print version of Child Health USA 2013 . Suggested Citation: U.S. Department of Health and ...

  1. 77 FR 70825 - Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC

    Science.gov (United States)

    2012-11-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC... November 5, 2012, Siegfried (USA) LLC, 33 Industrial Park Road, Pennsville, New Jersey 08070,...

  2. 78 FR 32458 - Manufacturer of Controlled Substances; Notice of Application; Siegfried USA, LLC

    Science.gov (United States)

    2013-05-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Siegfried USA, LLC... April 18, 2013, Siegfried USA, LLC., 33 Industrial Park Road, Pennsville, New Jersey 08070,...

  3. Dalai-laama saab hoolimata Hiina vihahoost USA medali / Krister Paris

    Index Scriptorium Estoniae

    Paris, Krister

    2007-01-01

    Dalai-laama saab Kongressi kuldmedali USA presidendilt George W. Bushilt, kes esimese võimul oleva USA presidendina ilmub dalai-laamaga avalikkuse ette. Hiina on teravalt reageerinud dalai-laama austamisele

  4. 75 FR 11937 - Ternium USA, Inc.; Shreveport, LA; Notice of Termination of Investigation

    Science.gov (United States)

    2010-03-12

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF LABOR Employment and Training Administration Ternium USA, Inc.; Shreveport, LA; Notice of Termination of..., USA, Inc., Shreveport, Louisiana. The petitioner has requested that the petition be...

  5. USA paneb välisabi kaitsma oma huve maailmas / Markus Larsson

    Index Scriptorium Estoniae

    Larsson, Markus

    2003-01-01

    USA valitsuse raporti kohaselt tuleb riigi välisabiprogramme hakata kohandama nii, et need oleksid suunatud USA rahvuslike huvide kaitsele ning vabaduse ja julgeoleku laiendamisele kogu maailmas. USAID juhataja Andrew Natsiose seisukohti

  6. Control of ciliary motility by Ca sup 2+ : Integration of Ca sup 2+ -dependent functions and targets for Ca sup 2+ action

    Energy Technology Data Exchange (ETDEWEB)

    Evans, T.C.

    1988-01-01

    To identify functions that regulate Ca{sup 2+}-induced ciliary reversal in Paramecium, mutants defective in terminating depolarization-induced backward swimming were selected. Six independent recessive mutations (k-shy) comprising two complementation groups, k-shyA and k-shyB, were identified. All mutants exhibited prolonged backward swimming in depolarizing solutions. Voltage clamp studies revealed that mutant Ca{sup 2+} current amplitudes were reduced, but could be restored to wild type levels by EGTA injection. The recovery of the mutant Ca{sup 2+} current from Ca{sup 2+}-dependent inactivation, and the decay of the Ca{sup 2+}-dependent K{sup +} and Ca{sup 2+}-dependent Na{sup +} currents after depolarization were slow in k-shy compared to wild type. To identify protein targets of Ca{sup 2+} action, ciliary proteins that interact with calmodulin (CaM) were characterized. With a {sup 125}I-CaM blot assay, several CaM-binding proteins were identified including axonemal, soluble, and membrane-bound polypeptides. Competitive displacement studies with unlabeled Paramecium CaM, bovine CaM, and troponinC suggested that both protein types bind CaM with high affinity and specificity. To examine the presence of CaM-binding sites in intact axonemes, a filtration binding assay was developed.

  7. Diffusion of Ca and Mg in Calcite

    Energy Technology Data Exchange (ETDEWEB)

    Cygan, R.T.; Fisler, D.K.

    1999-02-10

    The self-diffusion of Ca and the tracer diffusion of Mg in calcite have been experimentally measured using isotopic tracers of {sup 25}Mg and {sup 44}Ca. Natural single crystals of calcite were coated with a thermally-sputtered oxide thin film and then annealed in a CO{sub 2} gas at one atmosphere total pressure and temperatures from 550 to 800 C. Diffusion coefficient values were derived from the depth profiles obtained by ion microprobe analysis. The resultant activation energies for Mg tracer diffusion and Ca self-diffusion are respectively: E{sub a}(Mg) = 284 {+-} 74 kJ/mol and E{sub a}(Ca) = 271 {+-} 80 kJ/mol. For the temperature ranges in these experiments, the diffusion of Mg is faster than Ca. The results are generally consistent in magnitude with divalent cation diffusion rates obtained in previous studies and provide a means of interpreting the thermal histories of carbonate minerals, the mechanism of dolomitization, and other diffusion-controlled processes. The results indicate that cation diffusion in calcite is relatively slow and cations are the rate-limiting diffusing species for the deformation of calcite and carbonate rocks. Application of the calcite-dolomite geothermometer to metamorphic assemblages will be constrained by cation diffusion and cooling rates. The direct measurement of Mg tracer diffusion in calcite indicates that dolomitization is unlikely to be accomplished by Mg diffusion in the solid state but by a recrystallization process.

  8. Exploring Air-Climate-Energy Impacts with GCAM-USA

    Science.gov (United States)

    The Global Climate Assessment Model (GCAM) is a global integrated assessment model used for exploring future scenarios and examining strategies that address air pollution, climate change and energy (ACE) goals. My research focuseson integration of impact factors in GCAM-USA and a...

  9. USA on Iraagis ülbe ja rumal? / Tõnis Erilaid

    Index Scriptorium Estoniae

    Erilaid, Tõnis, 1943-

    2006-01-01

    USA välisministeeriumi ühe büroo avaliku diplomaatia direktor Alberto Fernandez tunnistas väidetavalt Al-Jazeera telekanalis esinedes, et ameeriklased olid Iraagis ülbed ja rumalad ning nüüd on vaja kõigi sealsete esindajatega läbirääkimisi pidada

  10. Miks USA ründab Iraani? / Gwynne Dyer

    Index Scriptorium Estoniae

    Dyer, Gwynne

    2006-01-01

    Ilmunud ka: Molodjozh Estonii 6. märts lk. 12. 20. märtsil avab Iraan uue börsi, kus kõik maad saavad osta ja müüa naftat ja gaasi mitte ainult dollarite, vaid ka eurode eest, selle mõju USA finantspositsioonile

  11. USA sepitseb uusi plaane Iraani mahasurumiseks / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2006-01-01

    Kommenteerides ÜRO ja Iraani tuumakõneluste ummikseisust väljumise võimalusi, tunnistas USA välisministeeriumi poliitikanõunik Nicholas Burns, et diplomaatia abil on keeruline veenda Iraani loobuma tuumatehnoloogia väljatöötamisest

  12. Duck Hunters’ Perceptions of Risk for Avian Influenza, Georgia, USA

    OpenAIRE

    Dishman, Hope; Stallknecht, David; Cole, Dana

    2010-01-01

    To determine duck hunters’ risk for highly pathogenic avian influenza, we surveyed duck hunters in Georgia, USA, during 2007–2008, about their knowledge, attitudes, and practices. We found they engage in several practices that could expose them to the virus. Exposures and awareness were highest for those who had hunted >10 years.

  13. Duck hunters' perceptions of risk for avian influenza, Georgia, USA.

    Science.gov (United States)

    Dishman, Hope; Stallknecht, David; Cole, Dana

    2010-08-01

    To determine duck hunters'risk for highly pathogenic avian influenza, we surveyed duck hunters in Georgia, USA, during 2007-2008, about their knowledge, attitudes, and practices. We found they engage in several practices that could expose them to the virus. Exposures and awareness were highest for those who had hunted >10 years.

  14. 76 FR 25527 - Law Day, U.S.A., 2011

    Science.gov (United States)

    2011-05-05

    ...#0;#0; ] Proclamation 8665 of April 29, 2011 Law Day, U.S.A., 2011 By the President of the United States of America A Proclamation At the core of our Nation's values is our faith in the ideals of equality and justice under law. It is a belief embedded in our most cherished documents, and honored by...

  15. Experiencing Second-Wave Feminism in the USA

    Science.gov (United States)

    Biklen, Sari; Marshall, Catherine; Pollard, Diane

    2008-01-01

    How has feminism mattered in the lives of particular academic feminists? Three scholars in education whose careers developed during the era of second-wave feminism describe how their personal and political stances were affected by theories, methodological advances, the milieus of academia as well as legal, and political events in the USA. The…

  16. USA folkloristid tutvustavad Eestis afroameerika rahvamuusikat / Andres Roost

    Index Scriptorium Estoniae

    Roost, Andres

    2008-01-01

    9. veebruaril tutvustavad USA folkloristid Anna Lomax Wood ja Todd Dunham Harvey Eesti Kirjandusmuuseumi saalis Tartus John A. Lomaxi (1867-1948) ja Alan Lomaxi (1915-2002) kogutud afroameerika folkloori, näidatakse dokumentaalfilmi "Land Where the Blues Began"

  17. Experiencing Second-Wave Feminism in the USA

    Science.gov (United States)

    Biklen, Sari; Marshall, Catherine; Pollard, Diane

    2008-01-01

    How has feminism mattered in the lives of particular academic feminists? Three scholars in education whose careers developed during the era of second-wave feminism describe how their personal and political stances were affected by theories, methodological advances, the milieus of academia as well as legal, and political events in the USA. The…

  18. Homeschooling in the USA: Past, Present and Future

    Science.gov (United States)

    Gaither, Milton

    2009-01-01

    This article first examines why the homeschooling movement in the USA emerged in the 1970s, noting the impact of political radicalism both right and left, feminism, suburbanization, and public school bureaucratization and secularization. It then describes how the movement, constituted of left- and right-wing elements, collaborated in the early…

  19. Julma USA sõdurit ootab elu vanglas / Evelyn Kaldoja

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2011-01-01

    USA sõjavägi hakkab mõistma kohut veebel Calvin Gibbsi üle, keda peetakse afgaani tsiviilisikuid tapnud ja ohvrite laipu rüvetanud jõugu eestvedajaks. Calvin Gibbs eitab kõiki talle esitatud süüdistusi

  20. EDITORIAL: THE STATUS OF LCA IN THE USA

    Science.gov (United States)

    Life Cycle Assessment (LCA) is alive and well in the USA. Concerns for environmental management, over strict command and control approaches, has led to an increasing presence of the life cycle concept since its initial appearance in the 1970's. In addition, the very reasonablen...

  1. Vaccinia virus infections in martial arts gym, Maryland, USA, 2008.

    Science.gov (United States)

    Hughes, Christine M; Blythe, David; Li, Yu; Reddy, Ramani; Jordan, Carol; Edwards, Cindy; Adams, Celia; Conners, Holly; Rasa, Catherine; Wilby, Sue; Russell, Jamaal; Russo, Kelly S; Somsel, Patricia; Wiedbrauk, Danny L; Dougherty, Cindy; Allen, Christopher; Frace, Mike; Emerson, Ginny; Olson, Victoria A; Smith, Scott K; Braden, Zachary; Abel, Jason; Davidson, Whitni; Reynolds, Mary; Damon, Inger K

    2011-04-01

    Vaccinia virus is an orthopoxvirus used in the live vaccine against smallpox. Vaccinia virus infections can be transmissible and can cause severe complications in those with weakened immune systems. We report on a cluster of 4 cases of vaccinia virus infection in Maryland, USA, likely acquired at a martial arts gym.

  2. USA sepitseb uusi plaane Iraani mahasurumiseks / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2006-01-01

    Kommenteerides ÜRO ja Iraani tuumakõneluste ummikseisust väljumise võimalusi, tunnistas USA välisministeeriumi poliitikanõunik Nicholas Burns, et diplomaatia abil on keeruline veenda Iraani loobuma tuumatehnoloogia väljatöötamisest

  3. USA kiidetud noise-rock Eestis / Annika Haas

    Index Scriptorium Estoniae

    Haas, Annika

    2008-01-01

    Müra-rock'i viljelevast USA duost Magik Markers (ansambel osaleb režissöör Veiko Õunapuu uue mängufilmi "Püha Tõnu kiusamine" võtetel ja annab kaks kontserti - 13. nov. Tallinnas klubis Tapper ja 15. nov. Tartus klubis Trehv)

  4. USA ajakirjaniku teos paljastab CIA nõrkusi / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 30. juuli 2007, lk. 6. New York Timesi ajakirjanik Tim Weiner annab oma äsjailmunud raamatus "Legacy of ashes: the history of the USA" põhjaliku ülevaate CIA ajaloost. Lisa: CIA läbikukkumiste jada

  5. Bush lubas Bagdadi rohkem USA sõdureid / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 28. juuli lk. 10. Iraagi peaministri Nuri Kamal al-Maliki USA visiidist, mille käigus ilmnesid kahe riigi vahelised erimeelsused, kokku lepiti lisajõudude saatmises Bagdadi. Lisa: Bagdadi julgeolek

  6. Comparing Teacher Dispositions in China and the USA

    Science.gov (United States)

    Shao, Kun; Tamashiro, Roy

    2013-01-01

    In studies conducted in the USA, teacher dispositional factors such as enthusiasm, professional esteem and learning motivation often emerge as the most significant variables affecting student learning and achievement from the primary grades through higher education. Do these factors play as significant a role in student learning and achievement in…

  7. USA ajakirjaniku teos paljastab CIA nõrkusi / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 30. juuli 2007, lk. 6. New York Timesi ajakirjanik Tim Weiner annab oma äsjailmunud raamatus "Legacy of ashes: the history of the USA" põhjaliku ülevaate CIA ajaloost. Lisa: CIA läbikukkumiste jada

  8. USA riigipeaks pürgijad saavad tuleristsed / Hendrik Vosman

    Index Scriptorium Estoniae

    Vosman, Hendrik

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke 28. dets. lk. 8. 2008. aasta 3. jaanuaril saavad alguse Iowa osariigis toimuval USA kohalike vabariiklaste ja demokraatide nõupidamisel viis kuud kestvad presidendikandidaatide eelvalimised. Lisa: Demokraatide seas on kaks selget liidrit, vabariiklaste seas on shansse viiel mehel. Vt. samas: Vabariiklaste must hobune

  9. Knemidocoptic Mange in Wild Golden Eagles, California, USA

    Centers for Disease Control (CDC) Podcasts

    2014-09-21

    Dr. Mike Miller reads an abridged version of the article, Knemidocoptic Mange in Wild Golden Eagles, California, USA .  Created: 9/21/2014 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 10/15/2014.

  10. Trichinella surveillance in black bears (Ursus americanus) from Oregon, USA.

    Science.gov (United States)

    Mortenson, J A; Kent, M L; Fowler, D R; Chomel, B B; Immell, D A

    2014-01-01

    We used serology and muscle digestion to test black bears (Ursus americanus) from western Oregon, USA, for Trichinella. Results indicate black bears in Oregon are not part of a sylvatic cycle for Trichinella, and risk of human exposure to Trichinella larvae from eating black bear meat from Oregon appears low.

  11. Status and migration of irrigation in the USA

    Science.gov (United States)

    Irrigated agriculture produces 49% of crop market value on 18% of cropped lands in the USA. Irrigation is essential to the most highly productive, intensely managed, and internationally competitive sectors of our agricultural economy, which play a key role in meeting growing global food, fiber, and ...

  12. Opsigtsvækkende nyt om derivater fra USA

    DEFF Research Database (Denmark)

    Thinggaard, Frank

    1997-01-01

    Der er opsigsvækkende nyt fra USA om den regnskabsmæssige behandling af derivater som terminskontrakter, futures, optioner, swaps m.v. Glem alt om historiske anskaffelsespriser. For derivater er der kun ét mål, som kan bruges: markedsværdier (fair-values). Glem alt om snakken om 'off-balance-sheet...

  13. Kuhu USAs investeerida, kui võidab...? / Mati Feldmann

    Index Scriptorium Estoniae

    Feldmann, Mati, 1961-

    2008-01-01

    Autor analüüsib investorite investeerimisvõimalusi sõltuvalt sellest, kas USA presidendivalimised võidab Barack Obama või John McCain. Vt. samas: Investoritel oleks mõttekas investeerida sõltuvalt võitjast

  14. USAs on kõik veel lahtine / Kertu Ruus

    Index Scriptorium Estoniae

    Ruus, Kertu, 1977-

    2008-01-01

    USA presidendivalimiste praeguses etapis võistlevad omavahel demokraatidest senaatorid Hillary Clinton ja Barack Obama, vabariiklastest tõusis esile senaator John McCain. Vt. samas: Katre Pilvinski. Politoloog: Eestil on kõvasti McCaini ja Clintoniga vedanud

  15. Titanium Technology in the USA-an Overview

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The state of Ti research, development and industry is reviewed in this article. The fifty-year anniversary of Ti technology commercialization in the USA provides an opportunity for a historical perspective. Incorporation of "information-age" tools into alloy development, processing, and production invigorates the technology. Consolidation, diversification and globalization have been transforming the Ti industry in the recent years.

  16. Plagiarism Litigation Trends in the USA and Australia

    Science.gov (United States)

    Mawdsley, Ralph D.; Cumming, J. Joy

    2008-01-01

    In this article we explore the increasing complexity of plagiarism litigation in the USA and Australia. Plagiarism has always been a serious academic issue and academic staff and students have wrestled with its definition and appropriate penalties for some time. However, the advent of the Internet and more freely accessible information resources,…

  17. President Ilves töövisiidil USAs

    Index Scriptorium Estoniae

    2009-01-01

    President Toomas Hendrik Ilves alustas töövisiiti USA läänerannikul, teadus- ja kõrgtehnoloogia keskuses Silicon Valley's. Riigipea kohtus ka San Francisco linnapea Gavin Newsom'iga ja Stanfordi Ülikooli rektori John L. Hennessy'ga. Vabariigi President töövisiidil Ameerika Ühendriikides 9.-16.06.2009

  18. Õhuvägi loobus USA pakutud lennukitest

    Index Scriptorium Estoniae

    2016-01-01

    Eesti õhuvägi loobus USA poolt kingituseks pakutud kahest sõjaväe transportlennukist Sherpa C-23B+. Põhjalikuma analüüsi tulemusel on kaalumisel alternatiivsed variandid ja Sherpasid õhuvägi praeguse seisuga kasutusse ei võta, ütles kaitseväe peastaabi pressiesindaja

  19. Litterfall mercury dry deposition in the eastern USA

    Science.gov (United States)

    Martin R. Risch; John F. DeWild; David P. Krabbenhoft; Randall K. Kolka; Leiming. Zhang

    2012-01-01

    Mercury (Hg) in autumn litterfall frompredominately deciduous forestswas measured in 3 years of samples from 23 Mercury Deposition Network sites in 15 states across the eastern USA. Annual litterfall Hg dry depositionwas significantly higher (median 12.3 micrograms per square meter (µg/m2), range 3.5-23.4 µg/m2...

  20. Euroopa tootjad ei ole rahul USA survega / Ain Lember

    Index Scriptorium Estoniae

    Lember, Ain

    2006-01-01

    Seoses USA survega Euroopa turgude avanemiseks ning probleemidega Brasiilia toidukaupade ekspordi osas, kutsub üleeuroopalise põllumajandustootjate liit COPA ja põllumajandustööandjate organisatsioonide liit COGECA Euroopa valitsusjuhte üles lõpetama järeleandmiste tegemise

  1. Integration of GCAM-USA into GLIMPSE: Update and demonstration

    Science.gov (United States)

    The purpose of this presentation is to (i) discuss changes made to the GCAM-USA model to more fully support long-term, coordinated environmental-climate-energy planning within the U.S., and (ii) demonstrate the graphical user interface that has been constructed to construct model...

  2. Bin Laden sekkus USA valimisvõitlusesse / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2004-01-01

    Terroripealik Osama bin Laden pöördus 29. oktoobril meedia vahendusel ameeriklaste poole ning märkis, et kui USA soovib vältida uusi 11. septembri laadseid rünnakuid, peab ta lõpetama moslemite julgeoleku ohustamise

  3. USA folkloristid tutvustavad Eestis afroameerika rahvamuusikat / Andres Roost

    Index Scriptorium Estoniae

    Roost, Andres

    2008-01-01

    9. veebruaril tutvustavad USA folkloristid Anna Lomax Wood ja Todd Dunham Harvey Eesti Kirjandusmuuseumi saalis Tartus John A. Lomaxi (1867-1948) ja Alan Lomaxi (1915-2002) kogutud afroameerika folkloori, näidatakse dokumentaalfilmi "Land Where the Blues Began"

  4. USA kapitalivoog jõuab Eestisse / Roland Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Roland

    2012-01-01

    Autor leiab, et on soodne hetk hakata arendama rohkem start-up ettevõtteid, kuna USA Föderaalreserv on aasta jooksul juurde trükkinud 600 miljardit dollarit ning Eesti Arengufondil ja riskikapitalifondidel nagu ASI on vajalik investeerimisraha olemas

  5. Knemidocoptic Mange in Wild Golden Eagles, California, USA

    Science.gov (United States)

    Stephenson, Nicole; Rogers, Krysta; Hawkins, Michelle G.; Sadar, Miranda; Guzman, David Sanchez-Migallon; Bell, Douglas A.; Smallwood, Kenneth S.; Wells, Amy; Shipman, Jessica; Foley, Janet

    2014-01-01

    During 2012–2013 in California, USA, 3 wild golden eagles were found with severe skin disease; 2 died. The cause was a rare mite, most closely related to Knemidocoptes derooi mites. Cautionary monitoring of eagle populations, habitats, and diseases is warranted. PMID:25271842

  6. Napier ootab USA aktsiatelt 30% tõusu / Romet Kreek

    Index Scriptorium Estoniae

    Kreek, Romet, 1972-

    2010-01-01

    Prantsusmaa suurpanga Credit Agricole üksuse CLSA strateegi Russell Napieri arvates on USA aktsiad karjuvalt madalalt hinnatud võrrreldes aktsiate dividendide ja ettevõtete kasumitega. Investeerimisel on tema soosingus kõrge dividenditootlusega aktsiad. Tema arvates hakkavad võlakirja tootlused järjekindlalt tõusma

  7. USA kiidetud noise-rock Eestis / Annika Haas

    Index Scriptorium Estoniae

    Haas, Annika

    2008-01-01

    Müra-rock'i viljelevast USA duost Magik Markers (ansambel osaleb režissöör Veiko Õunapuu uue mängufilmi "Püha Tõnu kiusamine" võtetel ja annab kaks kontserti - 13. nov. Tallinnas klubis Tapper ja 15. nov. Tartus klubis Trehv)

  8. Sourcing USA Summit Engages Global Cotton Industry Leaders

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    From November 9-12,the"6th Biennial Sourcing USA Summit,"organized by Cotton Council International and Cotton Incorporated and with the support of the U.S.cotton industry and USDA, took place at Terranea in Rancho Palos Verdes,

  9. Introduction: Exotic annual Bromus in the western USA [Chapter 1

    Science.gov (United States)

    Matthew J. Germino; Jeanne C. Chambers; Cynthia S. Brown

    2016-01-01

    The spread and impacts of exotic species are unambiguous, global threats to many ecosystems. A prominent example is the suite of annual grasses in the Bromus genus (Bromus hereafter) that originate from Europe and Eurasia but have invaded or are invading large areas of the Western USA. This book brings a diverse, multidisciplinary group of authors together to...

  10. Plagiarism Litigation Trends in the USA and Australia

    Science.gov (United States)

    Mawdsley, Ralph D.; Cumming, J. Joy

    2008-01-01

    In this article we explore the increasing complexity of plagiarism litigation in the USA and Australia. Plagiarism has always been a serious academic issue and academic staff and students have wrestled with its definition and appropriate penalties for some time. However, the advent of the Internet and more freely accessible information resources,…

  11. USA sõdib terrorismi vastu sobimatul moel / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2008-01-01

    Mõttekoja Rand Corporation analüüsi kohaselt ei piisa USA-l islamiekstremistidega võitlemisel vaid vägede suurendamisest, panustada tuleb kohalike võimude tõhustamisse, nende paremasse koolitamisse ja infovahetusse. Lisa: Guantanamo kuuik kohtu all

  12. USA kriitikud pärjasid Clint Eastwoodi / A. F.

    Index Scriptorium Estoniae

    A. F.

    2006-01-01

    USA rahvuslik filmikriitikute ühing (National Society of Film Critics) valis aasta parimaks filmiks Clint Eastwoodi "Kirjad Iwo Jimalt" ("Letters from Iwo Jima"), parimaks režissööriks Martin Scorsese ja parimaks võõrkeelseks filmiks Pedro Almodovari "Tagasitulek" ("Volver"). Sõnumis on ekslikult Iowa pro Iwa ja Almadovar pro Almodovar

  13. USA kapitalivoog jõuab Eestisse / Roland Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Roland

    2012-01-01

    Autor leiab, et on soodne hetk hakata arendama rohkem start-up ettevõtteid, kuna USA Föderaalreserv on aasta jooksul juurde trükkinud 600 miljardit dollarit ning Eesti Arengufondil ja riskikapitalifondidel nagu ASI on vajalik investeerimisraha olemas

  14. The Current Landscape of the School Librarianship Curricula in USA

    Science.gov (United States)

    Yi, Kwan; Turner, Ralph

    2014-01-01

    The current landscape of the School Librarianship educational programs and curricula of master's degrees in the USA has been explored. The master's programs are currently offered in the following four venues: (1) programs that are American Library Association (ALA) accredited but not American Association of School Librarians (AASL) recognized,…

  15. 75 FR 24369 - Law Day, U.S.A., 2010

    Science.gov (United States)

    2010-05-05

    ...#0;#0; ] Proclamation 8511 of April 29, 2010 Law Day, U.S.A., 2010 By the President of the United States of America A Proclamation For over two centuries, our Nation has adhered to the rule of law as the foundation for a safe, free, and just society. President Eisenhower, seeking to formally recognize...

  16. Kas maailm vajab USA-vastast allianssi? / Mihhail Gorbatshov

    Index Scriptorium Estoniae

    Gorbatšov, Mihhail, 1931-

    2007-01-01

    Kasvanud on Brasiilia, Venemaa, India ja Hiina majanduslik võimsus ja poliitiline tähtsus, neid riike ei saa enam kohelda maailmaasjades alandavalt, ütleb autor. USA püüdlustest võtta endale maailma liidriroll ja rakendada seda peamiselt sõjaliste vahenditega

  17. Rethinking Postgraduate Geography Education in the USA: Issues and Concerns

    Science.gov (United States)

    Foote, Kenneth; Bednarz, Sarah; Monk, Janice; Solem, Michael; Stoltman, Joseph

    2012-01-01

    Postgraduate geography education in the USA is growing and changing. In recent years, the number of postgraduate programs has increased at both the doctoral and master's levels. Interest in improving and reforming doctoral education has increased dramatically both inside and outside geography, and geography has been involved in these reforms.…

  18. USA meedia kritiseerib Obama välispoliitikat / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2009-01-01

    ÜRO peaassambleel võeti vastu Ameerika Ühendriikide presidendi juhtimisel resolutsioon, kus kinnitatakse taas tahet muuta maailm tuumarelvavabaks, kuid USA ajakirjanikud ja poliitikud leiavad, et president ei ole maailmapoliitikas eriti midagi saavutanud. 25. septembril toimunud G20 tippkohtumisel otsustati, et globaalset majandust puudutavates küsimustes võetakse G8-lt juhiroll üle

  19. Protecting nature : organizations and networks in Europe and the USA.

    NARCIS (Netherlands)

    Koppen, van C.S.A.; Markham, W.T.

    2007-01-01

    This book offers a comparative analysis of organizations and networks involved in nature protection in France, Germany, Italy, the Netherlands, Norway, Poland, Sweden, the UK and the USA. It traces their development from their origins, more than a century ago, to the present day. Throughout this per

  20. USA suursaadik ja eurovolinik taunisid piirijärjekordi

    Index Scriptorium Estoniae

    2007-01-01

    Narva töövisiidi teinud USA suursaadik Eestis Stanley Davis Phillips kritiseerib Eesti-Vene piiril valitsevat olukorda, Riigikogu komisjonidega kohtunud EL-i transpordiküsimuste volinik Jacques Barrot peab piiriületusjärjekordade põhjuseks Vene tollitöötajate puudulikku pädevust, korruptsiooni ja poliitilisi põhjusi

  1. President Ilves töövisiidil USAs

    Index Scriptorium Estoniae

    2009-01-01

    President Toomas Hendrik Ilves alustas töövisiiti USA läänerannikul, teadus- ja kõrgtehnoloogia keskuses Silicon Valley's. Riigipea kohtus ka San Francisco linnapea Gavin Newsom'iga ja Stanfordi Ülikooli rektori John L. Hennessy'ga. Vabariigi President töövisiidil Ameerika Ühendriikides 9.-16.06.2009

  2. Monitoring Drosophila suzukii Matsumura in Oregon, USA sweet cherry orchards.

    Science.gov (United States)

    Drosophila suzukii rapidly became a significant cherry pest in the western United States after it was observed damaging cherries in 2009 in California. It has caused significant damage to ripening cherries in all major USA cherry production districts leading to increased management costs and reduced...

  3. USA300 Methicillin-resistant Staphylococcus aureus in Cuba

    Directory of Open Access Journals (Sweden)

    Hopman Joost

    2012-01-01

    Full Text Available Abstract Background Methicillin-resistant Staphylococcus aureus is an increasing problem in the Caribbean. We investigated the molecular epidemiology of MRSA isolates on Cuba. Findings The predominant clone was of the spa type t149, followed by community-associated MRSA USA300. Conclusions We report the first molecular typing results of MRSA isolates from Cuba.

  4. Reflections on Women and the Law in the USA

    Science.gov (United States)

    Epstein, Cynthia Fuchs

    2008-01-01

    The USA has undergone extraordinary changes over the past 35 years with respect to women's access to equality in education, employment and participation in political life. This has come about because of the introduction of anti-discrimination legislation and because of the activities of professional organisations in activating the implementation…

  5. USA kriitikud pärjasid Clint Eastwoodi / A. F.

    Index Scriptorium Estoniae

    A. F.

    2006-01-01

    USA rahvuslik filmikriitikute ühing (National Society of Film Critics) valis aasta parimaks filmiks Clint Eastwoodi "Kirjad Iwo Jimalt" ("Letters from Iwo Jima"), parimaks režissööriks Martin Scorsese ja parimaks võõrkeelseks filmiks Pedro Almodovari "Tagasitulek" ("Volver"). Sõnumis on ekslikult Iowa pro Iwa ja Almadovar pro Almodovar

  6. USA leiab maailmas aina enam hukkamõistu / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 25. jaan. 2007, lk. 9. 25 maailma riigis korraldatud BBC küsitlusuurimus näitas, et üha suurem osa maailmast mõistab hukka USA praeguse kursi, eriti pälvib kriitikat sõda Iraagis ja terroristide vangilaagri pidamine Kuubal Guantanamo Bays

  7. San Juan Basin, USA; coalbed methane development and production

    Energy Technology Data Exchange (ETDEWEB)

    Gluskoter, H. [US Geological Survey, Reston, VA (USA)

    2002-07-01

    Twenty one slides/overheads outline the talk on production of coalbed methane from sedimentary basins in the USA. Figures are given for production and reserves for the year 2000. The San Juan basin's geologic structure, containing resources of the Cretaceous coal age, primarily in the Fruitland Formation, is described. 4 refs.

  8. USA sõdurid tulevad Paidesse ja Türile

    Index Scriptorium Estoniae

    2015-01-01

    USA laseb Eestisse toodud Strykeri soomukitel läbi kuue riigi Saksamaale kodubaasi sõita. 1700-kilomeetrise retke eesmärk on näidata nii eurooplastele kui ka Venemaale, et NATO suudab sõjatehnikat kiiresti ja lihtsalt üle riigipiiride liigutada. Peatutakse ka Paides ja Türil

  9. Napier ootab USA aktsiatelt 30% tõusu / Romet Kreek

    Index Scriptorium Estoniae

    Kreek, Romet, 1972-

    2010-01-01

    Prantsusmaa suurpanga Credit Agricole üksuse CLSA strateegi Russell Napieri arvates on USA aktsiad karjuvalt madalalt hinnatud võrrreldes aktsiate dividendide ja ettevõtete kasumitega. Investeerimisel on tema soosingus kõrge dividenditootlusega aktsiad. Tema arvates hakkavad võlakirja tootlused järjekindlalt tõusma

  10. USA on Iraagis ülbe ja rumal? / Tõnis Erilaid

    Index Scriptorium Estoniae

    Erilaid, Tõnis, 1943-

    2006-01-01

    USA välisministeeriumi ühe büroo avaliku diplomaatia direktor Alberto Fernandez tunnistas väidetavalt Al-Jazeera telekanalis esinedes, et ameeriklased olid Iraagis ülbed ja rumalad ning nüüd on vaja kõigi sealsete esindajatega läbirääkimisi pidada

  11. Sexual Orientation Topics in Educational Leadership Programmes across the USA

    Science.gov (United States)

    Jennings, Todd

    2012-01-01

    This investigation examines the inclusion of sexual orientation topics within the formal curriculum of 55 public college and university educational administration/leadership programmes across the USA. The findings indicate that programmes place a low priority upon sexual orientation compared to other diversity topics and that 59.5% of programmes…

  12. Ca-alginate-entrapped nanoscale iron: arsenic treatability and mechanism studies

    Science.gov (United States)

    Bezbaruah, Achintya N.; Kalita, Harjyoti; Almeelbi, Talal; Capecchi, Christopher L.; Jacob, Donna L.; Ugrinov, Angel G.; Payne, Scott A.

    2014-01-01

    The use of nanoscale zero-valent iron (NZVI, diameter 10-90 nm with an average value of 35 nm) entrapped in calcium (Ca)-alginate beads shows great promise for aqueous arsenic treatment. This research evaluated Ca-alginate-entrapped NZVI as an advanced treatment technique for aqueous arsenic removal. Arsenic is a serious threat to human health and millions of people are affected by arsenic contamination in various parts of the world including the USA. In bench scale batch studies with initial As(V) concentrations of 1-10 mg L-1, 85-100 % arsenic removal was achieved within 2 h. While the reaction kinetics differ between bare and entrapped NZVI, the overall reductions of arsenic are comparable. Surface area-normalized arsenic reduction reaction rate constants ( k sa) for bare and entrapped NZVI were 3.40-5.96 × 10-3 and 3.92-4.43 × 10-3 L m-2 min-1, respectively. The entrapped NZVI removed 100 μg L-1 As(V) to below detection limit within 2 h and groundwater with 53 μg L-1 As(V) was remediated to below instrument detection limit (10 μg L-1) within 1 h. The presence of Na+, Ca2+, Cl-, and HCO3^{ - }did not affect arsenic removal by entrapped NZVI and there was no leaching of iron from the beads. X-ray diffraction and Fourier transform infrared spectroscopic techniques have been used to understand the mechanism of arsenic removal by the entrapped NZVI. Ca-alginate polymer is an excellent choice as an entrapment medium as it is non-toxic and has little solubility in water.

  13. Redetermination of metarossite, CaV5+2O6·2H2O

    Directory of Open Access Journals (Sweden)

    Anaïs Kobsch

    2016-09-01

    Full Text Available The crystal structure of metarossite, ideally CaV2O6·2H2O [chemical name: calcium divanadium(V hexaoxide dihydrate], was first determined using precession photographs, with fixed isotropic displacement parameters and without locating the positions of the H atoms, leading to a reliability factor R = 0.11 [Kelsey & Barnes (1960. Can. Mineral. 6, 448–466]. This communication reports a structure redetermination of this mineral on the basis of single-crystal X-ray diffraction data of a natural sample from the Blue Cap mine, San Juan County, Utah, USA (R1 = 0.036. Our study not only confirms the structural topology reported in the previous study, but also makes possible the refinement of all non-H atoms with anisotropic displacement parameters and all H atoms located. The metarossite structure is characterized by chains of edge-sharing [CaO8] polyhedra parallel to [100] that are themselves connected by chains of alternating [VO5] trigonal bipyramids parallel to [010]. The two H2O molecules are bonded to Ca. Analysis of the displacement parameters show that the [VO5] chains librate around [010]. In addition, we measured the Raman spectrum of metarossite and compared it with IR and Raman data previously reported. Moreover, heating of metarossite led to a loss of water, which results in a transformation to the brannerite-type structure, CaV2O6, implying a possible dehydration pathway for the compounds M2+V2O6·xH2O, with M = Cu, Cd, Mg or Mn, and x = 2 or 4.

  14. Clinical significance of detecting CEA, CA199, AFP, HCG, CA153, CA125 in postoperative treatment of patients with ovarian cancer

    Institute of Scientific and Technical Information of China (English)

    Xue Pan; Zhen-Hua Du

    2016-01-01

    Objective:To explore the clinical significance of carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), a tire protein (AFP), human chorionic gonadotropin (HCG), carbohydrate antigen 153 (CA153) and carbohydrate antigen 125 (CA125) in the postoperative treatment of patients with ovarian cancer.Methods:210 cases of patients with ovarian cancer after initial treatment from January 2015 to December 2015, 232 cases of patients with ovarian benign tumor and 250 cases of healthy women were selected, CEA, CA199, AFP, HCG, CA153 and CA125 levels were detected, and the levels after chemotherapy in patients with ovarian carcinoma were detected.Results:CEA, CA199, AFP, HCG, CA153 and CA125 levels in patients with ovarian cancer were (12.37±7.43) ng/mL, (84.04±26.96) U/mL, (37.46±9.47) μg/L, (110.54±35.51) IU/L, (51.23±9.20) U/mL and (64.36±42.68) U/mL, respectively, which were significantly higher than that in normal controls and patients with benign ovarian lesions, and were considered to be statistically significant. Chemotherapy after two cycles, CEA, CA199, AFP, HCG, CA153 and CA125 levels in patients with ovarian cancer were significantly lower than that before chemotherapy, and were considered to be statistically different. Chemotherapy after four cycles, CEA, CA199, AFP, HCG, CA153 and CA125 levels in patients with ovarian cancer continue to decrease, and were significantly lower than that of chemotherapy after two cycles, and had statistical differences.Conclusion:CEA, CA199, AFP, HCG, CA153 and CA125 can be used as important indicators for monitoring the chemotherapy effects, early recurrence and metastasis of ovarian cancer.

  15. The USA-National Phenology Network Biophysical Program

    Science.gov (United States)

    Losleben, M. V.; Crimmins, T. M.; Weltzin, J. F.

    2009-12-01

    On January 1, 2009, the USA National Phenology Network (USA-NPN, www.usanpn.org) launched the USA-NPN Biophysical Program. The overarching goal of the Biophysical Program (BP) is to link phenology, the study of recurring plant and animal life cycle stages, with climate through the integration of phenology observations, meteorological, and spectral remote sensing measurements at sites across a broad a spectrum of environments. Phenology is critical for understanding a changing world. Many of the recurring plant and animal life cycle stages such as leafing and flowering of plants, maturation of agricultural crops, emergence of insects, and migration of birds are sensitive to climatic variation and change, and are simple to observe and record. Such changes can effect, for example, timing mismatches between the emergence of food sources and the arrival of migrating populations, or create new disease and invasive species vectors via increasingly suitable growing seasons relative to the climatic life cycle requirements of hosts or the organisms themselves. New vectors or crashing populations can have major repercussions on entire ecosystems and regional economics. Thus, to track phenology and build a national database, the USA-NPN is providing standard phenology monitoring protocols. Further, the integration of weather stations with phenological data provides an opportunity to understand how a changing climate is altering phenology. Thus, the USA-NPN Biophysical Program is developing an integrative biology-climate site template for widespread dissemination, in collaboration with the Rocky Mountain Biological Laboratory (RMBL, http://rmbl.org/rockymountainbiolab/). This poster presents the USA-NPN Biophysical Program, and the results of the collaboration with RMBL during the summer of 2009, including the installation of an elevational network of climate stations. The National Science Foundation’s Major Research Instrumentation (NSF’s MRI) program provides funding

  16. USA ärritab Poolat ideega ehitada raketikilp hoopis Leetu / Evelyn Kaldoja

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2008-01-01

    Kuigi USA ja Poola vahel jätkuvad läbirääkimised raketikilbi üle, on rahvusvahelisse meediasse imbunud oletus, et USA võib raketikilbi paigutada hoopis Leetu. Poola asevälisministri Witold Waszczykowski hinnangul kasutab USA Leedut survestusvahendina. Nii Leedu välisministeerium kui ka USA-poolne kõneluste juht John Rood kinnitavad, et raketikilbiküsimust on riigid omavahel arutanud

  17. Afganistan ja USA tülitsevad vangide ja oopiumi pärast / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2005-01-01

    USA presidendi George W. Bushiga kohtumise järel nõudis Afganistani president Hamid Karzai USA käes olevate Afganistani vangide väljaandmist, ta oli nördinud teadete üle, kuidas vange on koheldud. Karzai nõudis kontrolli Afganistanis viibivate USA sõdurite üle ja relvastatud reidide lõpetamist afgaanide kodudesse. Lisa: USA ründab Afganistani narkoäri

  18. Eesti saab tõenäoliselt USA-lt pooletoobise viisavabaduse / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2008-01-01

    Algasid läbirääkimised USA-ga viisavabaduse saavutamiseks. USA eksperdid tulevad hindama Eesti riigipiiri pidavust, koostatakse vastastikuse arusaamise memorandum. Tõenäoliselt hakkab Eesti puhul kehtima teistsugune süsteem kui on praegu 27 riigil, kellel on USA-ga viisavabadus ja kellest 15 on EL-i nn vanad riigid. USA sisejulgeoleku ministeeriumi asekantsleri Richard Barthi seisukohti. Vt. samas: Eesti näide võib tekitada vastuolulist reaktsiooni

  19. Eesti saab tõenäoliselt USA-lt pooletoobise viisavabaduse / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2008-01-01

    Algasid läbirääkimised USA-ga viisavabaduse saavutamiseks. USA eksperdid tulevad hindama Eesti riigipiiri pidavust, koostatakse vastastikuse arusaamise memorandum. Tõenäoliselt hakkab Eesti puhul kehtima teistsugune süsteem kui on praegu 27 riigil, kellel on USA-ga viisavabadus ja kellest 15 on EL-i nn vanad riigid. USA sisejulgeoleku ministeeriumi asekantsleri Richard Barthi seisukohti. Vt. samas: Eesti näide võib tekitada vastuolulist reaktsiooni

  20. Afganistan ja USA tülitsevad vangide ja oopiumi pärast / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2005-01-01

    USA presidendi George W. Bushiga kohtumise järel nõudis Afganistani president Hamid Karzai USA käes olevate Afganistani vangide väljaandmist, ta oli nördinud teadete üle, kuidas vange on koheldud. Karzai nõudis kontrolli Afganistanis viibivate USA sõdurite üle ja relvastatud reidide lõpetamist afgaanide kodudesse. Lisa: USA ründab Afganistani narkoäri