WorldWideScience

Sample records for suites mediate group-level

  1. Computer-mediated support group intervention for parents.

    Science.gov (United States)

    Bragadóttir, Helga

    2008-01-01

    The purpose of this study was to evaluate the feasibility of a computer-mediated support group (CMSG) intervention for parents whose children had been diagnosed with cancer. An evaluative one-group, before-and-after research design. A CMSG, an unstructured listserve group where participants used their E-mail for communication, was conducted over a 4-month period. Participation in the CMSG was offered to parents in Iceland whose children had completed cancer treatment in the past 5 years. Outcome measures were done: before the intervention (Time 1), after 2 months of intervention (Time 2) and after 4 months of intervention (Time 3) when the project ended. Measures included: demographic and background variables; health related vulnerability factors of parents: anxiety, depression, somatization, and stress; perceived mutual support; and use of the CMSG. Data were collected from November 2002 to June 2003. Twenty-one of 58 eligible parents participated in the study, with 71% retention rate for both post-tests. Mothers' depression decreased significantly from Time 2 to Time 3 (pcomputer technology for support is particularly useful for dispersed populations and groups that have restrictions on their time. Computer-mediated support groups have been shown to be a valuable addition to, or substitute for, a traditional face-to-face mutual support group and might suit both genders equally.

  2. Extended tree-level gauge mediation

    DEFF Research Database (Denmark)

    Monaco, M.; Nardecchia, M.; Romanino, A.

    2011-01-01

    Tree-level gauge mediation (TGM) is a scenario of SUSY breaking in which the tree-level exchange of heavy (possibly GUT) vector fields generates flavor-universal sfermion masses. In this work we extend this framework to the case of E(6) that is the natural extension of the minimal case studied so...... if the gauge group does not contain SU(5). If SUSY breaking is mediated purely by the U(1) generator that commutes with SO(10) we obtain universal sfermion masses and thus can derive the CMSSM boundary conditions in a novel scenario....

  3. Preferences for group dominance track and mediate the effects of macro-level social inequality and violence across societies

    Science.gov (United States)

    Kunst, Jonas R.; Sidanius, Jim; Thomsen, Lotte

    2017-01-01

    Whether and how societal structures shape individual psychology is a foundational question of the social sciences. Combining insights from evolutionary biology, economy, and the political and psychological sciences, we identify a central psychological process that functions to sustain group-based hierarchies in human societies. In study 1, we demonstrate that macrolevel structural inequality, impaired population outcomes, socio-political instability, and the risk of violence are reflected in the endorsement of group hegemony at the aggregate population level across 27 countries (n = 41,824): The greater the national inequality, the greater is the endorsement of between-group hierarchy within the population. Using multilevel analyses in study 2, we demonstrate that these psychological group-dominance motives mediate the effects of macrolevel functioning on individual-level attitudes and behaviors. Specifically, across 30 US states (n = 4,613), macrolevel inequality and violence were associated with greater individual-level support of group hegemony. Crucially, this individual-level support, rather than cultural-societal norms, was in turn uniquely associated with greater racism, sexism, welfare opposition, and even willingness to enforce group hegemony violently by participating in ethnic persecution of subordinate out-groups. These findings suggest that societal inequality is reflected in people’s minds as dominance motives that underpin ideologies and actions that ultimately sustain group-based hierarchy. PMID:28484013

  4. Preferences for group dominance track and mediate the effects of macro-level social inequality and violence across societies.

    Science.gov (United States)

    Kunst, Jonas R; Fischer, Ronald; Sidanius, Jim; Thomsen, Lotte

    2017-05-23

    Whether and how societal structures shape individual psychology is a foundational question of the social sciences. Combining insights from evolutionary biology, economy, and the political and psychological sciences, we identify a central psychological process that functions to sustain group-based hierarchies in human societies. In study 1, we demonstrate that macrolevel structural inequality, impaired population outcomes, socio-political instability, and the risk of violence are reflected in the endorsement of group hegemony at the aggregate population level across 27 countries ( n = 41,824): The greater the national inequality, the greater is the endorsement of between-group hierarchy within the population. Using multilevel analyses in study 2, we demonstrate that these psychological group-dominance motives mediate the effects of macrolevel functioning on individual-level attitudes and behaviors. Specifically, across 30 US states ( n = 4,613), macrolevel inequality and violence were associated with greater individual-level support of group hegemony. Crucially, this individual-level support, rather than cultural-societal norms, was in turn uniquely associated with greater racism, sexism, welfare opposition, and even willingness to enforce group hegemony violently by participating in ethnic persecution of subordinate out-groups. These findings suggest that societal inequality is reflected in people's minds as dominance motives that underpin ideologies and actions that ultimately sustain group-based hierarchy.

  5. Does Group-Level Commitment Predict Employee Well-Being?: A Prospective Analysis.

    Science.gov (United States)

    Clausen, Thomas; Christensen, Karl Bang; Nielsen, Karina

    2015-11-01

    To investigate the links between group-level affective organizational commitment (AOC) and individual-level psychological well-being, self-reported sickness absence, and sleep disturbances. A total of 5085 care workers from 301 workgroups in the Danish eldercare services participated in both waves of the study (T1 [2005] and T2 [2006]). The three outcomes were analyzed using linear multilevel regression analysis, multilevel Poisson regression analysis, and multilevel logistic regression analysis, respectively. Group-level AOC (T1) significantly predicted individual-level psychological well-being, self-reported sickness absence, and sleep disturbances (T2). The association between group-level AOC (T1) and psychological well-being (T2) was fully mediated by individual-level AOC (T1), and the associations between group-level AOC (T1) and self-reported sickness absence and sleep disturbances (T2) were partially mediated by individual-level AOC (T1). Group-level AOC is an important predictor of employee well-being in contemporary health care organizations.

  6. Does Group-Level Commitment Predict Employee Well-Being?

    DEFF Research Database (Denmark)

    Clausen, Thomas; Christensen, Karl Bang; Nielsen, Karina

    2015-01-01

    OBJECTIVE: To investigate the links between group-level affective organizational commitment (AOC) and individual-level psychological well-being, self-reported sickness absence, and sleep disturbances. METHODS: A total of 5085 care workers from 301 workgroups in the Danish eldercare services parti...... disturbances (T2) were partially mediated by individual-level AOC (T1). CONCLUSIONS: Group-level AOC is an important predictor of employee well-being in contemporary health care organizations.......OBJECTIVE: To investigate the links between group-level affective organizational commitment (AOC) and individual-level psychological well-being, self-reported sickness absence, and sleep disturbances. METHODS: A total of 5085 care workers from 301 workgroups in the Danish eldercare services...

  7. Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures.

    Science.gov (United States)

    Janosko, Krisztina; Holbrook, Michael R; Adams, Ricky; Barr, Jason; Bollinger, Laura; Newton, Je T'aime; Ntiforo, Corrie; Coe, Linda; Wada, Jiro; Pusl, Daniela; Jahrling, Peter B; Kuhn, Jens H; Lackemeyer, Matthew G

    2016-10-03

    Biosafety level 4 (BSL-4) suit laboratories are specifically designed to study high-consequence pathogens for which neither infection prophylaxes nor treatment options exist. The hallmarks of these laboratories are: custom-designed airtight doors, dedicated supply and exhaust airflow systems, a negative-pressure environment, and mandatory use of positive-pressure ("space") suits. The risk for laboratory specialists working with highly pathogenic agents is minimized through rigorous training and adherence to stringent safety protocols and standard operating procedures. Researchers perform the majority of their work in BSL-2 laboratories and switch to BSL-4 suit laboratories when work with a high-consequence pathogen is required. Collaborators and scientists considering BSL-4 projects should be aware of the challenges associated with BSL-4 research both in terms of experimental technical limitations in BSL-4 laboratory space and the increased duration of such experiments. Tasks such as entering and exiting the BSL-4 suit laboratories are considerably more complex and time-consuming compared to BSL-2 and BSL-3 laboratories. The focus of this particular article is to address basic biosafety concerns and describe the entrance and exit procedures for the BSL-4 laboratory at the NIH/NIAID Integrated Research Facility at Fort Detrick. Such procedures include checking external systems that support the BSL-4 laboratory, and inspecting and donning positive-pressure suits, entering the laboratory, moving through air pressure-resistant doors, and connecting to air-supply hoses. We will also discuss moving within and exiting the BSL-4 suit laboratories, including using the chemical shower and removing and storing positive-pressure suits.

  8. Transformational leadership and group potency in small military units: The mediating role of group identification and cohesion

    Directory of Open Access Journals (Sweden)

    Carlos García-Guiu

    2016-12-01

    Full Text Available In the present study, we examined an exploratory model to assess the relationship between transformational leadership and group potency and analyze the mediating role of group identification and cohesion. The research was conducted with squads of the Spanish Army. The sample was composed of 243 members of 51 squads of operational units. Our findings highlighted the importance of the transformational leadership style of command of non-commissioned officers (NCOs due to its positive relationship with the group potency of the squad. We also analyzed the indirect relationships between transformational leadership and group identification and group cohesion and found that the latter variables played a mediating role between transformational leadership and group potency. The conclusions of this study are relevant due to the growing importance of transformational leadership and actions implemented at lower levels of the command chain for the success of missions of security organizations and defense.

  9. Single-Level and Multilevel Mediation Analysis

    Science.gov (United States)

    Tofighi, Davood; Thoemmes, Felix

    2014-01-01

    Mediation analysis is a statistical approach used to examine how the effect of an independent variable on an outcome is transmitted through an intervening variable (mediator). In this article, we provide a gentle introduction to single-level and multilevel mediation analyses. Using single-level data, we demonstrate an application of structural…

  10. GHRSST Level 2P 1 m Depth Global Sea Surface Temperature from the Visible Infrared Imaging Radiometer Suite (VIIRS) on the Suomi NPP satellite (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on retrievals from the Visible Infrared Imaging Radiometer Suite (VIIRS)....

  11. Computer-mediated and face-to-face communication in metastatic cancer support groups.

    Science.gov (United States)

    Vilhauer, Ruvanee P

    2014-08-01

    To compare the experiences of women with metastatic breast cancer (MBC) in computer-mediated and face-to-face support groups. Interviews from 18 women with MBC, who were currently in computer-mediated support groups (CMSGs), were examined using interpretative phenomenological analysis. The CMSGs were in an asynchronous mailing list format; women communicated exclusively via email. All the women were also, or had previously been, in a face-to-face support group (FTFG). CMSGs had both advantages and drawbacks, relative to face-to-face groups (FTFGs), for this population. Themes examined included convenience, level of support, intimacy, ease of expression, range of information, and dealing with debilitation and dying. CMSGs may provide a sense of control and a greater level of support. Intimacy may take longer to develop in a CMSG, but women may have more opportunities to get to know each other. CMSGs may be helpful while adjusting to a diagnosis of MBC, because women can receive support without being overwhelmed by physical evidence of disability in others or exposure to discussions about dying before they are ready. However, the absence of nonverbal cues in CMSGs also led to avoidance of topics related to death and dying when women were ready to face them. Agendas for discussion, the presence of a facilitator or more time in CMSGs may attenuate this problem. The findings were discussed in light of prevailing research and theories about computer-mediated communication. They have implications for designing CMSGs for this population.

  12. Suites of dwarfs around Nearby giant galaxies

    International Nuclear Information System (INIS)

    Karachentsev, Igor D.; Kaisina, Elena I.; Makarov, Dmitry I.

    2014-01-01

    The Updated Nearby Galaxy Catalog (UNGC) contains the most comprehensive summary of distances, radial velocities, and luminosities for 800 galaxies located within 11 Mpc from us. The high density of observables in the UNGC makes this sample indispensable for checking results of N-body simulations of cosmic structures on a ∼1 Mpc scale. The environment of each galaxy in the UNGC was characterized by a tidal index Θ 1 , depending on the separation and mass of the galaxy's main disturber (MD). We grouped UNGC galaxies with a common MD in suites, and ranked suite members according to their Θ 1 . All suite members with positive Θ 1 are assumed to be physical companions of the MD. About 58% of the sample are members of physical groups. The distribution of suites by the number of members, n, follows a relation N(n) ∼ n –2 . The 20 most populated suites contain 468 galaxies, i.e., 59% of the UNGC sample. The fraction of MDs among the brightest galaxies is almost 100% and drops to 50% at M B = –18 m . We discuss various properties of MDs, as well as galaxies belonging to their suites. The suite abundance practically does not depend on the morphological type, linear diameter, or hydrogen mass of the MD, the tightest correlation being with the MD dynamical mass. Dwarf galaxies around MDs exhibit well-known segregation effects: the population of the outskirts has later morphological types, richer H I contents, and higher rates of star formation activity. Nevertheless, there are some intriguing cases where dwarf spheroidal galaxies occur at the far periphery of the suites, as well as some late-type dwarfs residing close to MDs. Comparing simulation results with galaxy groups, most studies assume the Local Group is fairly typical. However, we recognize that the nearby groups significantly differ from each other and there is considerable variation in their properties. The suites of companions around the Milky Way and M31, consisting of the Local Group, do not

  13. Improved airline-type supplied-air plastic suit

    International Nuclear Information System (INIS)

    Jolley, L. Jr.; Zippler, D.B.; Cofer, C.H.; Harper, J.A.

    1978-06-01

    Two piece supplied-air plastic suits are used extensively at the Savannah River Plant for personnel protection against inhalation of airborne plutonium and tritium. Worker comfort and noise level problems gave impetus to development of an improved suit and aid distribution system. The resulting plastic suit and development work are discussed. The plastic suit unit cost is less than $20, the hearing zone noise level is less than 75 dBA, protection factors exceed 10,000, and user comfort is approved. This suit is expected to meet performance requirements for unrestricted use

  14. Gender diversity and motivation in collaborative learning groups : the mediating role of group discussion quality

    NARCIS (Netherlands)

    Curseu, P.L.; Chappin, M.M.H.|info:eu-repo/dai/nl/304835056; Jansen, Rob J. G.

    Collaborative learning is often used in higher education to help students develop their teamwork skills and acquire curricular knowledge. In this paper we test a mediation model in which the quality of group discussions mediates the impact of gender diversity and group motivation on collaborative

  15. Gender diversity and motivation in collaborative learning groups : The mediating role of group discussion quality

    NARCIS (Netherlands)

    Curseu, Petre; Chappin, M.M.H.; Jansen, R.J.G.

    2018-01-01

    Collaborative learning is often used in higher education to help students develop their teamwork skills and acquire curricular knowledge. In this paper we test a mediation model in which the quality of group discussions mediates the impact of gender diversity and group motivation on collaborative

  16. Analytical Tools for Space Suit Design

    Science.gov (United States)

    Aitchison, Lindsay

    2011-01-01

    As indicated by the implementation of multiple small project teams within the agency, NASA is adopting a lean approach to hardware development that emphasizes quick product realization and rapid response to shifting program and agency goals. Over the past two decades, space suit design has been evolutionary in approach with emphasis on building prototypes then testing with the largest practical range of subjects possible. The results of these efforts show continuous improvement but make scaled design and performance predictions almost impossible with limited budgets and little time. Thus, in an effort to start changing the way NASA approaches space suit design and analysis, the Advanced Space Suit group has initiated the development of an integrated design and analysis tool. It is a multi-year-if not decadal-development effort that, when fully implemented, is envisioned to generate analysis of any given space suit architecture or, conversely, predictions of ideal space suit architectures given specific mission parameters. The master tool will exchange information to and from a set of five sub-tool groups in order to generate the desired output. The basic functions of each sub-tool group, the initial relationships between the sub-tools, and a comparison to state of the art software and tools are discussed.

  17. Focus point gauge mediation in product group unification

    International Nuclear Information System (INIS)

    Bruemmer, Felix; Ibe, Masahiro; Tokyo Univ., Kashiwa; Yanagida, Tsutomu T.

    2013-03-01

    In certain models of gauge-mediated supersymmetry breaking with messenger fields in incomplete GUT multiplets, the radiative corrections to the Higgs potential cancel out during renormalization group running. This allows for relatively heavy superpartners and for a 125 GeV Higgs while the ne-tuning remains modest. In this paper, we show that such gauge mediation models with ''focus point'' behaviour can be naturally embedded into a model of SU(5) x U(3) product group unification.

  18. Mediated Intercultural Communication Barrier in No Drama Zone! Group

    OpenAIRE

    Lizal, Valentino

    2015-01-01

    This research study aimed to describe the mediated intercultural communication barriers in the No Drama Zone! group. This study is a qualitative descriptive type of research, with case study method. By doing in depth interview and observation, researcher found two barriers that generates other barriers in the group's mediated intercultural communication. The two big barriers were: language and physical barriers. Language barriers in this group generated two barriers, emotional barrier and pe...

  19. Focus point gauge mediation in product group unification

    Energy Technology Data Exchange (ETDEWEB)

    Bruemmer, Felix [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Ibe, Masahiro [Tokyo Univ., Kashiwa (Japan). Kavli IPMU, TODIAS; Tokyo Univ., Kashiwa (Japan). ICRR; Yanagida, Tsutomu T. [Tokyo Univ., Kashiwa (Japan). Kavli IPMU, TODIAS

    2013-03-15

    In certain models of gauge-mediated supersymmetry breaking with messenger fields in incomplete GUT multiplets, the radiative corrections to the Higgs potential cancel out during renormalization group running. This allows for relatively heavy superpartners and for a 125 GeV Higgs while the ne-tuning remains modest. In this paper, we show that such gauge mediation models with ''focus point'' behaviour can be naturally embedded into a model of SU(5) x U(3) product group unification.

  20. Effect of the cooling suit method applied to individuals with multiple sclerosis on fatigue and activities of daily living.

    Science.gov (United States)

    Özkan Tuncay, Fatma; Mollaoğlu, Mukadder

    2017-12-01

    To determine the effects of cooling suit on fatigue and activities of daily living of individuals with multiple sclerosis. Fatigue is one of the most common symptoms in people with multiple sclerosis and adversely affects their activities of daily living. Studies evaluating fatigue associated with multiple sclerosis have reported that most of the fatigue cases are related to the increase in body temperature and that cooling therapy is effective in coping with fatigue. This study used a two sample, control group design. The study sample comprised 75 individuals who met the inclusion criteria. Data were collected with study forms. After the study data were collected, cooling suit treatment was administered to the experimental group. During home visits paid at the fourth and eighth weeks after the intervention, the aforementioned scales were re-administered to the participants in the experimental and control groups. The analyses performed demonstrated that the severity levels of fatigue experienced by the participants in the experimental group wearing cooling suit decreased. The experimental group also exhibited a significant improvement in the participants' levels of independence in activities of daily living. The cooling suit worn by individuals with multiple sclerosis was determined to significantly improve the participants' levels of fatigue and independence in activities of daily living. The cooling suit therapy was found to be an effective intervention for the debilitating fatigue suffered by many multiple sclerosis patients, thus significantly improving their level of independence in activities of daily living. © 2017 John Wiley & Sons Ltd.

  1. Collective nostalgia: A group-level emotion that confers unique benefits on the group.

    Science.gov (United States)

    Wildschut, Tim; Bruder, Martin; Robertson, Sara; van Tilburg, Wijnand A P; Sedikides, Constantine

    2014-11-01

    This research established collective nostalgia as a group-level emotion and ascertained the benefits it confers on the group. In Study 1, participants who reflected on a nostalgic event they had experienced together with ingroup members (collective nostalgia) evaluated the ingroup more positively and reported stronger intentions to approach (and not avoid) ingroup members than those who recalled a nostalgic event they had experienced individually (personal nostalgia), those who reflected on a lucky event they had experienced together with ingroup members (collective positive), and those who did not recall an event (no recall). In Study 2, collective (vs. personal) nostalgia strengthened behavioral intentions to support the ingroup more so than did recalling an ordinary collective (vs. personal) event. Increased collective self-esteem mediated this effect. In Study 3, collective nostalgia (compared with recall of an ordinary collective event) led participants to sacrifice money in order to punish a transgression perpetrated against an ingroup member. This effect of collective nostalgia was more pronounced when social identification was high (compared with low). Finally, in Study 4, collective nostalgia converged toward the group average (i.e., was socially shared) when participants thought of themselves in terms of their group membership. The findings underscore the viability of studying nostalgia at multiple levels of analysis and highlight the significance of collective nostalgia for understanding group-level attitudes, global action tendencies, specific behavioral intentions, and behavior.

  2. Platinum-group element geochemistry used to determine Cu and Au fertility in the Northparkes igneous suites, New South Wales, Australia

    Science.gov (United States)

    Hao, Hongda; Campbell, Ian H.; Park, Jung-Woo; Cooke, David R.

    2017-11-01

    Recent studies have shown that platinum-group elements (PGE) can be used to constrain the timing of sulfide saturation in evolving felsic systems. In this study, we report trace-element, PGE, Re and Au data for the barren and ore-associated suites of intermediate to felsic rocks from the Northparkes Cu-Au porphyry region, emphasizing the timing of sulfide saturation and its influence on the tenor of the associated hydrothermal mineralization. Two barren suites, the Goonumbla and Wombin Volcanics and associate intrusive rocks, are found in the region. Geochemical modelling shows that the barren suites are dominated by plagioclase-pyroxene fractionation, whereas the ore-associated Northparkes Cu-Au porphyry suite is characterized by plagioclase-amphibole fractionation, which requires the ore-bearing suite to have crystallized from a wetter magma than barren suites. The concentrations of PGE, Re and Au in the barren suites decrease continuously during fractional crystallization. This is attributed to early sulfide saturation with the fraction of immiscible sulfide precipitation required to produce the observed trend, being 0.13 and 0.16 wt.% for the Goonumbla and Wombin suites, respectively. The calculated partition coefficients for Au and Pd required to model the observed change in these elements with MgO are well below published values, indicating that R, the mass ratio of silicate to sulfide melt, played a significant role in controlling the rate of decline of these elements with fractionation. Palladium in the ore-associated suite, in contrast, first increases with fractionation then decreases abruptly at 1.2 wt.% MgO. The sharp decrease is attributed to the onset of sulfide precipitation. Platinum on the other hand shows a moderate decrease, starting from the highest MgO sample analysed, but then decreasing strongly from 1.2 wt.% MgO. The initial Pt decrease is attributed to precipitation of a platinum-group mineral (PGM), probably a Pt-Fe alloy, and the sharp

  3. mediation: R package for causal mediation analysis

    OpenAIRE

    Tingley, Dustin; Yamamoto, Teppei; Hirose, Kentaro; Keele, Luke; Imai, Kosuke

    2012-01-01

    In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding the process in which the treatment causally affects the outcome. Causal mediation analysis is frequently used to assess potential causal mechanisms. The mediation package implements a comprehensive suite of statistical tools for conducting su...

  4. The formation of group norms in computer-mediated communication

    NARCIS (Netherlands)

    Postmes, T; Spears, R; Lea, M

    The formation of group norms in computer-mediated communication (CMC) was examined among students who used e-mail as part of a course. A network analysis of group structures revealed that (a) content and form of communication is normative, group norms defining communication patterns within groups,

  5. Mediation and spillover effects in group-randomized trials: a case study of the 4Rs educational intervention

    Science.gov (United States)

    VanderWeele, Tyler J.; Hong, Guanglei; Jones, Stephanie M.; Brown, Joshua L.

    2013-01-01

    Peer influence and social interactions can give rise to spillover effects in which the exposure of one individual may affect outcomes of other individuals. Even if the intervention under study occurs at the group or cluster level as in group-randomized trials, spillover effects can occur when the mediator of interest is measured at a lower level than the treatment. Evaluators who choose groups rather than individuals as experimental units in a randomized trial often anticipate that the desirable changes in targeted social behaviors will be reinforced through interference among individuals in a group exposed to the same treatment. In an empirical evaluation of the effect of a school-wide intervention on reducing individual students’ depressive symptoms, schools in matched pairs were randomly assigned to the 4Rs intervention or the control condition. Class quality was hypothesized as an important mediator assessed at the classroom level. We reason that the quality of one classroom may affect outcomes of children in another classroom because children interact not simply with their classmates but also with those from other classes in the hallways or on the playground. In investigating the role of class quality as a mediator, failure to account for such spillover effects of one classroom on the outcomes of children in other classrooms can potentially result in bias and problems with interpretation. Using a counterfactual conceptualization of direct, indirect and spillover effects, we provide a framework that can accommodate issues of mediation and spillover effects in group randomized trials. We show that the total effect can be decomposed into a natural direct effect, a within-classroom mediated effect and a spillover mediated effect. We give identification conditions for each of the causal effects of interest and provide results on the consequences of ignoring “interference” or “spillover effects” when they are in fact present. Our modeling approach

  6. Attitudes toward healthy eating: a mediator of the educational level-diet relationship.

    Science.gov (United States)

    Lê, J; Dallongeville, J; Wagner, A; Arveiler, D; Haas, B; Cottel, D; Simon, C; Dauchet, L

    2013-08-01

    A higher educational level is associated with a healthier diet. The goal of this study was to establish whether this association is mediated by attitudes toward healthy eating. The cross-sectional MONA LISA-NUT study was performed in 2005-2007 on adults aged 35-64 years from northern and north-eastern France. Diet quality was assessed on the basis of a 3-day food record and a validated score based on French national dietary guidelines. Specific questions investigated attitudes toward healthy eating. Multivariate analyses were used to quantify the proportion of the educational level-diet relationship that was mediated by attitudes toward healthy eating. Among the 1631 subjects, favourable attitudes toward healthy eating were associated with both higher educational level and diet quality. In the mediation analysis, 'organic food consumption' explained 14% (95% confidence interval (8;24)) of the educational level-diet relationship and 'attention paid to health when buying food' explained 9% (3;16). In contrast, 'attention to food choice', 'searching for information about food' and 'perceived role of eating' were not mediators of the association between educational level and diet. In a multivariate model, the attitude items together accounted for 25% (10;45) of the relationship. The mediation was more pronounced in women than in men (37% (15;54) vs 16% (1;27), respectively) and was significant for consumption of fruits and vegetables (23% (13;37)), whole-grain food (32% (15;58)) and seafood (22% (9;55)). Our results suggest that poor attitudes toward healthy eating in groups with low socioeconomic status constitute an additional factor (along with cost constraints) in the choice of unhealthy foods.

  7. Selected Food Consumption Mediates the Association between Education Level and Metabolic Syndrome in Korean Adults.

    Science.gov (United States)

    Kim, Oh Yoen; Kwak, So-Young; Kim, Boeun; Kim, Young-Sun; Kim, Hye Young; Shin, Min-Jeong

    2017-01-01

    Low socioeconomic status (SES) is linked to higher incidence/mortality of cardiovascular disease, but emerging evidence inconsistently reported that education level, a proxy for SES, is related to cardiovascular risk and metabolic syndrome (MetS) in Koreans. Furthermore, limited information is available on whether dietary components would mediate the relationship between education level and cardiovascular risk. We hypothesized that selected food consumption mediates the association between education level and MetS prevalence. Data from the Korea National Health and Nutritional Examination Survey (2008-2011) were included in cross-sectional analyses (n = 11,029, 30-64 years). The possible mediating effect of selected food groups (fruits, raw vegetables, red meat, milk, and soft drinks) on the association between education level and MetS was tested using a multiple mediation model. Education level was negatively associated with MetS prevalence. The association between lower education level and higher MetS prevalence was partially mediated by selected food consumption (lower intakes of fruit, red meat and milk; higher intakes of vegetable and soft drink) after adjusted for covariates. Gender also modified the association between education level and MetS prevalence that was more prominent in women than in men. Selected food consumption substantially contributes to the association between education level and MetS in Korean adults, especially among women. © 2017 S. Karger AG, Basel.

  8. Computer-Mediated Collaborative Projects: Processes for Enhancing Group Development

    Science.gov (United States)

    Dupin-Bryant, Pamela A.

    2008-01-01

    Groups are a fundamental part of the business world. Yet, as companies continue to expand internationally, a major challenge lies in promoting effective communication among employees who work in varying time zones. Global expansion often requires group collaboration through computer systems. Computer-mediated groups lead to different communicative…

  9. PERCEPTIONS OF CLOSE AND GROUP RELATIONSHIPS MEDIATE THE RELATIONSHIP BETWEEN ANXIETY AND DEPRESSION OVER A DECADE LATER.

    Science.gov (United States)

    Jacobson, Nicholas C; Newman, Michelle G

    2016-01-01

    Previous research has demonstrated that anxiety reliably predicts later depression, but little has been uncovered about the mechanism underlying this connection. Interpersonal relationships appear to be a viable mechanism of the association as anxiety has been shown to predict later deficits in both close (e.g., "best friendships") and group relationships (e.g., classroom peer groups), and deficits in both close and group relationships have been linked to later depressive symptoms. The current study examined close and group relationships as potential mediators between anxiety and depression 12-14 years later. In a nationally representative sample of adolescents (N = 6,504), anxiety was measured at baseline, perceptions of close relationships (i.e., feeling loved) and perceptions of group relationships (i.e., feeling part of a group) were measured 6 months later, and depression levels and diagnosis were measured 12-14 years later. Using structural equation models, the results showed that adolescent perceptions of both close and group relationships significantly mediated the relationship between adolescent anxiety and adult levels of depression. Furthermore, perceptions of not being accepted/loved in close relationships significantly mediated the relationship between adolescent anxiety and clinical depression in adulthood. These results suggest that a perception of not being accepted in group relationships may be a mechanism by which heightened anxiety in adolescents leads to heightened nonclinical depression in adulthood. On the other hand, adolescent perceptions of not feeling loved or accepted in close relationships may be a mechanism by which heightened anxiety in adolescence leads to clinical depression--in adulthood. © 2015 Wiley Periodicals, Inc.

  10. Z-1 Prototype Space Suit Testing Summary

    Science.gov (United States)

    Ross, Amy

    2013-01-01

    The Advanced Space Suit team of the NASA-Johnson Space Center performed a series of test with the Z-1 prototype space suit in 2012. This paper discusses, at a summary level, the tests performed and results from those tests. The purpose of the tests were two-fold: 1) characterize the suit performance so that the data could be used in the downselection of components for the Z-2 Space Suit and 2) develop interfaces with the suitport and exploration vehicles through pressurized suit evaluations. Tests performed included isolated and functional range of motion data capture, Z-1 waist and hip testing, joint torque testing, CO2 washout testing, fit checks and subject familiarizations, an exploration vehicle aft deck and suitport controls interface evaluation, delta pressure suitport tests including pressurized suit don and doff, and gross mobility and suitport ingress and egress demonstrations in reduced gravity. Lessons learned specific to the Z-1 prototype and to suit testing techniques will be presented.

  11. SUIT

    DEFF Research Database (Denmark)

    Algreen-Ussing, Gregers; Wedebrunn, Ola

    2003-01-01

    Leaflet om project SUIT udgivet af European Commission. Tryksagen forklarer i korte ord resultatet af projektet SUIT. Kulturværdier i Miljøspørgsmål. Vurdering af projekter og indvirkning på miljø....

  12. Relationship between Individual and Organizational Learning: Mediating Role of Team Learning

    Directory of Open Access Journals (Sweden)

    Monika Stelmaszczyk

    2016-12-01

    Full Text Available The aim of this paper is to recognize the relationships between individual and organizational learning while considering team learning as a mediator of these relationships. The research object is a large Polish enterprise specializing in the production of cast-iron items. In order to test assumed research hypotheses, statistical analyses were conducted using the IBM SPSS Statistics Suite, version 20. The suite helped conduct correlation analyses concatenation, line regression analyses and mediation analyses using the PROCESS macro by Hayes and Preacher. The research results show a statistically significant relationship between individual learning and each of the five dimensions of organizational learning [clarity of purpose and mission; leadership commitment and empowerment; knowledge transfer; experimentation and rewards; and teamwork and group problem solving]. What is more, they prove that team learning is a mediator of a relationship between individual and organizational learning. Interestingly, only one full mediation has been observed while researching the mediative effect of team learning in relation to each out of the five dimensions of organizational learning. It occurred in relation to experimentation and rewards. In the remaining cases these were partial mediations.

  13. The Mediating Role of Teachers' Depression Levels on the Relationship between Emotional Labor and Burn-Out

    Science.gov (United States)

    Yasar, Hasan; Demir, Selim

    2015-01-01

    The aim of this study is to understand the mediation effects of teachers' depression levels on the relationship between emotional labor and burnout. The study group in this research consists of 163 teachers working at Gaziantep schools during 2013-2014 academic year. Since the research aims to analyze mediation effect of teachers' depression…

  14. BMI mediates the association between low educational level and higher blood pressure during pregnancy in Japan.

    Science.gov (United States)

    Jwa, Seung Chik; Fujiwara, Takeo; Hata, Akira; Arata, Naoko; Sago, Haruhiko; Ohya, Yukihiro

    2013-04-25

    Research investigating the association between socioeconomic status (SES) and blood pressure (BP) during pregnancy is limited and its underlying pathway is unknown. The aim of this study was to investigate the mediators of the association between educational level as an indicator of the SES and BP in early and mid-pregnancy among Japanese women. Nine hundred and twenty-three pregnant women in whom BP was measured before 16 weeks and at 20 weeks of gestation were enrolled in this study. Maternal educational levels were categorized into three groups: high (university or higher), mid (junior college), and low (junior high school, high school, or vocational training school). The low educational group had higher systolic (low vs. high, difference = 2.39 mmHg, 95% confidence interval [CI]: 0.59 to 4.19) and diastolic BP levels (low vs. high, difference = 0.74 mmHg, 95% CI: -0.52 to 1.99) in early pregnancy. However, the same associations were not found after adjustment for pre-pregnancy body mass index (BMI). BP reduction was observed in mid-pregnancy in all three educational groups and there was no association between educational level and pregnancy-induced hypertension. In Japanese women, the low educational group showed higher BP during pregnancy than the mid or high educational groups. Pre-pregnancy BMI mediates the association between educational level and BP.

  15. Can Synchronous Computer-Mediated Communication (CMC) Help Beginning-Level Foreign Language Learners Speak?

    Science.gov (United States)

    Ko, Chao-Jung

    2012-01-01

    This study investigated the possibility that initial-level learners may acquire oral skills through synchronous computer-mediated communication (SCMC). Twelve Taiwanese French as a foreign language (FFL) students, divided into three groups, were required to conduct a variety of tasks in one of the three learning environments (video/audio, audio,…

  16. Z-2 Suit Support Stand and MKIII Suit Center of Gravity Test

    Science.gov (United States)

    Nguyen, Tuan Q.

    2014-01-01

    NASA's next generation spacesuits are the Z-Series suits, made for a range of possible exploration missions in the near future. The prototype Z-1 suit has been developed and assembled to incorporate new technologies that has never been utilized before in the Apollo suits and the Extravehicular Mobility Unit (EMU). NASA engineers tested the Z-1 suit extensively in order to developed design requirements for the new Z-2 suit. At the end of 2014, NASA will be receiving the new Z-2 suit to perform more testing and to further develop the new technologies of the suit. In order to do so, a suit support stand will be designed and fabricated to support the Z-2 suit during maintenance, sizing, and structural leakage testing. The Z-2 Suit Support Stand (Z2SSS) will be utilized for these purposes in the early testing stages of the Z-2 suit.

  17. What was uniform about the fin-de-siècle sailor suit?

    Science.gov (United States)

    Rose, Clare

    2011-01-01

    The sailor suits widely worn by children in late-nineteenth-century Britain have been interpreted at the time, and since, as expressions of an Imperial ethos. Yet, a closer examination of the ways that these garments were produced by mass manufacturers, mediated by advertisers and fashion advisors and consumed by families makes us question this characterization. Manufacturers interpreted sailor suits not as unchanging uniforms but as fashion items responding to seasonal changes. Consumers used them to assert social identities and social distinctions, selecting from the multiple variants available. Cultural commentators described sailor suits as emulating Royal practice—but also as ‘common’ and to be avoided. A close analysis of large samples of images and texts from the period 1870–1900 reveals how these different meanings overlapped, making the fin-de-siècle sailor suit a garment that undermines many of our assumptions.

  18. Directing-Group-mediated C-H-Alkynylations.

    Science.gov (United States)

    Caspers, Lucien D; Nachtsheim, Boris J

    2018-05-18

    C-C triple bonds are amongst the most versatile functional groups in synthetic chemistry. Complementary to the Sonogashira coupling the direct metal-catalyzed alkynylation of C-H bonds has emerged as a highly promising approach in recent years. To guarantee a high regioselectivity suitable directing groups (DGs) are necessary to guide the transition metal (TM) into the right place. In this Focus Review we present the current developments in DG-mediated C(sp 2 )-H and C(sp 3 )-H modifications with terminal alkynes under oxidative conditions and with electrophilic alkynylation reagents. We will discuss further modifications of the alkyne, in particular subsequent cyclizations to carbo- and heterocycles and modifications of the DG in the presence of the alkyne. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Plasma levels of immunosuppressive mediators during cardiopulmonary bypass

    Directory of Open Access Journals (Sweden)

    E. Borrelli

    1996-01-01

    Full Text Available The aim of this study was to evaluate plasma levels of two mediators with immunosuppressive properties, complement fraction C3a (C3a and transforming growth factor-β1 (TGF-β1, during extracorporeal circulation. The proliferation index after phytohaemagglutinin (PHA stimulation of isolated peripheral blood mononuclear cells was also investigated. Sixteen patients undergoing hypothermic (n = 8, group 1 and normothermic (n = 8, group 2 cardiopulmormry bypass (CPB were enrolled in this study. As a control, we evaluated four patients undergoing thoracovascular operations without CPB. Blood samples were collected before CPB but after anaesthesia, every 30 min during CPB, at the end of CPB and 10 min after protamine administration. Both C3a and TGF-β1 increased significantly during CPB and after protamine administration in the hypothermic as well as the normothermic group. In the latter case the increase of C3a and TGF-β1, although more prominent, was not significantl higher than in the former group. Conversely, the proliferation, index of peripheral mononuclear cells had already decreased 30 min after CPB was started and remained depressed throughout the CPB time. These results suggest a possible role of C3a and TGF-β1 in the immunological changes occurring during extracorporeal circulation.

  20. Innovative technology summary report: Sealed-seam sack suits

    International Nuclear Information System (INIS)

    1998-09-01

    Sealed-seam sack suits are an improved/innovative safety and industrial hygiene technology designed to protect workers from dermal exposure to contamination. Most of these disposable, synthetic-fabric suits are more protective than cotton suits, and are also water-resistant and gas permeable. Some fabrics provide a filter to aerosols, which is important to protection against contamination, while allowing air to pass, increasing comfort level of workers. It is easier to detect body-moisture breakthrough with the disposable suits than with cotton, which is also important to protecting workers from contamination. These suits present a safe and cost-effective (6% to 17% less expensive than the baseline) alternative to traditional protective clothing. This report covers the period from October 1996 to August 1997. During that time, sealed-seam sack suits were demonstrated during daily activities under normal working conditions at the C Reactor and under environmentally controlled conditions at the Los Alamos National Laboratory (LANL)

  1. Comparative Analysis of Tear Film Levels of Inflammatory Mediators in Contact Lens Users.

    Science.gov (United States)

    Yüksel Elgin, Cansu; İskeleli, Güzin; Talaz, Serap; Akyol, Sibel

    2016-04-01

    To compare tear films levels of various inflammatory cytokines in asymptomatic contact lens (CL) users. CL users of rigid gas-permeable CLs (RGPCL) (group 1) or silicone hydrogel CLs (SiHCL) (group 2) were compared with non-CL-using healthy subjects (group 3). Tear samples were collected from subjects in each group after ensuring that there were no complications secondary to CL wear in the CL-wearing participants. Tear-film levels of interleukins (ILs)-1β, -6, and -8; granulocyte-macrophage colony-stimulating factor (GM-CSF) (using the Luminex method); and leukotriene B4 (LTB4) (using the ELISA method) were determined. Cytokine levels were compared among the three groups using analysis-of-variance (ANOVA) and Kruskall-Wallis tests. There were significant differences in concentrations of IL-1β, GM-CSF and LTB4 among the three groups (p = 0.002, p = 0.021 and p = 0.009, respectively), as shown by the Kruskall-Wallis test comparing all three groups for the three cytokines. There were no significant differences for IL-6 and IL-8 (p = 0.079 and 0.094, respectively) when all three groups were compared. There were substantial statistically significant differences between RGPCL users, SiHCL users and control subjects in levels of tear film cytokines. Although CL users were asymptomatic, changes in tear-film levels of several important inflammatory mediators revealed that a chronic inflammatory process occurs during CL wear.

  2. Development of Advanced Suite of Deterministic Codes for VHTR Physics Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Seog; Cho, J. Y.; Lee, K. H. (and others)

    2007-07-15

    Advanced Suites of deterministic codes for VHTR physics analysis has been developed for detailed analysis of current and advanced reactor designs as part of a US-ROK collaborative I-NERI project. These code suites include the conventional 2-step procedure in which a few group constants are generated by a transport lattice calculation, and the reactor physics analysis is performed by a 3-dimensional diffusion calculation, and a whole core transport code that can model local heterogeneities directly at the core level. Particular modeling issues in physics analysis of the gas-cooled VHTRs were resolved, which include a double heterogeneity of the coated fuel particles, a neutron streaming in the coolant channels, a strong core-reflector interaction, and large spectrum shifts due to changes of the surrounding environment, temperature and burnup. And the geometry handling capability of the DeCART code were extended to deal with the hexagonal fuel elements of the VHTR core. The developed code suites were validated and verified by comparing the computational results with those of the Monte Carlo calculations for the benchmark problems.

  3. Supporting Family Carers Through Telephone-Mediated Group Programs: Opportunities For Gerontological Social Workers.

    Science.gov (United States)

    Shanley, Chris

    2008-01-01

    Telephone-mediated group programs are an important but under-utilized medium for reaching frail or disabled older persons' family carers who are in need of support. The primary purpose and style of group programs can range across a broad spectrum–encompassing educational, supportive and therapeutic types. Gerontological social workers are the members of the multidisciplinary care team whose training, experience and supervision makes them most suitable for facilitating this broad range of group types. Drawing on the experience of training a number of group facilitators, this article provides suggestions for social workers contemplating the use of telephone-mediated groups and highlights groupwork skills peculiar to conducting group programs via the telephone.

  4. Data Mediation with Enterprise Level Security

    Directory of Open Access Journals (Sweden)

    Kevin E. Foltz

    2017-10-01

    Full Text Available Enterprise Level Security (ELS is an architecture for enabling information sharing with strong security guarantees. It is built upon basic tenets and concepts that shape its component technologies and implementation. One challenge in sharing information is that the source and recipient of the information may use different units, protocols, data formats, or tools to process information. As a result, a transformation of the data is needed before the recipient can use the information. These conversions introduce potential security weaknesses into an ELS system, so an approach for enterprise-wide mediation is required. Methods in common use today, such as a man-in-the-middle (MITM translation and an online mediation service, do not preserve the basic ELS tenets and concepts. This paper examines these existing approaches and compares them with two new approaches designed to preserve ELS security. It looks at the complete picture of security, performance, and ease of implementation, offering a framework for choosing the best mediation approach based on the data sharing context.

  5. Opportunities knock: Mediation of peer-relations during meal-time in toddler groups

    Directory of Open Access Journals (Sweden)

    Ellen Os

    2013-11-01

    Full Text Available According to socio-cultural perspectives, adults are seen as mediators of cultural believes, values and practices. Qualitative analyses of teachers’ mediation of peer relations based on video-recordings in 9 toddler-groups indicate that meal-time represents opportunities for teachers to facilitate togetherness and peer-relations between toddlers. The teachers might facilitate sharing, passing food, routinized practices such as singing, and conversations. The results indicate variations between child- and group-oriented approaches, and accomplishing meals in an effective way. The child- and group-oriented approaches are marked by encouragement of toddlers’ initiatives and teachers supporting peer-interactions. Raising teachers’ consciousness about their contributions to children’s development of peer-relations and togetherness in group settings might contribute to enhance reflected practices in working with toddlers in groups.

  6. Validation suite for MCNP

    International Nuclear Information System (INIS)

    Mosteller, Russell D.

    2002-01-01

    Two validation suites, one for criticality and another for radiation shielding, have been defined and tested for the MCNP Monte Carlo code. All of the cases in the validation suites are based on experiments so that calculated and measured results can be compared in a meaningful way. The cases in the validation suites are described, and results from those cases are discussed. For several years, the distribution package for the MCNP Monte Carlo code1 has included an installation test suite to verify that MCNP has been installed correctly. However, the cases in that suite have been constructed primarily to test options within the code and to execute quickly. Consequently, they do not produce well-converged answers, and many of them are physically unrealistic. To remedy these deficiencies, sets of validation suites are being defined and tested for specific types of applications. All of the cases in the validation suites are based on benchmark experiments. Consequently, the results from the measurements are reliable and quantifiable, and calculated results can be compared with them in a meaningful way. Currently, validation suites exist for criticality and radiation-shielding applications.

  7. mediation: R Package for Causal Mediation Analysis

    Directory of Open Access Journals (Sweden)

    Dustin Tingley

    2014-09-01

    Full Text Available In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding the process in which the treatment causally affects the outcome. Causal mediation analysis is frequently used to assess potential causal mechanisms. The mediation package implements a comprehensive suite of statistical tools for conducting such an analysis. The package is organized into two distinct approaches. Using the model-based approach, researchers can estimate causal mediation effects and conduct sensitivity analysis under the standard research design. Furthermore, the design-based approach provides several analysis tools that are applicable under different experimental designs. This approach requires weaker assumptions than the model-based approach. We also implement a statistical method for dealing with multiple (causally dependent mediators, which are often encountered in practice. Finally, the package also offers a methodology for assessing causal mediation in the presence of treatment noncompliance, a common problem in randomized trials.

  8. Effect of hydromorphone hydrochloride combined with ropivacaine for PCEA after orthopedic surgery on the synthesis of pain mediators, inflammatory mediator and oxygen free radicals

    Directory of Open Access Journals (Sweden)

    Liang-Ying Luo

    2017-08-01

    Full Text Available Objective: To explore the effect of hydromorphone hydrochloride combined with ropivacaine for PCEA after orthopedic surgery on the synthesis of pain mediators, inflammatory mediator and oxygen free radicals. Methods: A total of 120 patients with fracture who underwent operation in the hospital between July 2014 and December 2016 were collected and divided into control group and observation group according to the random number table method, 60 cases in each group. Control group received morphine hydrochloride combined with ropivacaine for analgesia, observation group received hydromorphone hydrochloride combined with ropivacaine for analgesia, and the postoperative analgesia lasted for 48 h. The differences in serum levels of pain mediators, inflammatory mediators and oxidative stress indexes were compared between the two groups. Results: Immediately after operation, the differences in serum levels of pain mediators, inflammatory mediators and oxidative stress indexes were not statistically significant between the two groups. 48 h after operation, serum PGE2, SP, β-EP, IL-6, MCP-1, HMGB-1 and MDA levels of both groups of patients were significantly lower than those immediately after operation while Cu-Zn SOD and GSH-Px levels were significantly higher than those immediately after operation, and serum PGE2, SP, β-EP, IL-6, MCP-1, HMGB-1 and MDA levels of observation group were significantly lower than those of control group while Cu-Zn SOD and GSH-Px levels were significantly higher than those of control group. Conclusion: Hydromorphone hydrochloride combined with ropivacaine for PCEA after orthopedic surgery is effective in alleviating pain and inhibiting systemic inflammatory response.

  9. Open architecture of smart sensor suites

    Science.gov (United States)

    Müller, Wilmuth; Kuwertz, Achim; Grönwall, Christina; Petersson, Henrik; Dekker, Rob; Reinert, Frank; Ditzel, Maarten

    2017-10-01

    Experiences from recent conflicts show the strong need for smart sensor suites comprising different multi-spectral imaging sensors as core elements as well as additional non-imaging sensors. Smart sensor suites should be part of a smart sensor network - a network of sensors, databases, evaluation stations and user terminals. Its goal is to optimize the use of various information sources for military operations such as situation assessment, intelligence, surveillance, reconnaissance, target recognition and tracking. Such a smart sensor network will enable commanders to achieve higher levels of situational awareness. Within the study at hand, an open system architecture was developed in order to increase the efficiency of sensor suites. The open system architecture for smart sensor suites, based on a system-of-systems approach, enables combining different sensors in multiple physical configurations, such as distributed sensors, co-located sensors combined in a single package, tower-mounted sensors, sensors integrated in a mobile platform, and trigger sensors. The architecture was derived from a set of system requirements and relevant scenarios. Its mode of operation is adaptable to a series of scenarios with respect to relevant objects of interest, activities to be observed, available transmission bandwidth, etc. The presented open architecture is designed in accordance with the NATO Architecture Framework (NAF). The architecture allows smart sensor suites to be part of a surveillance network, linked e.g. to a sensor planning system and a C4ISR center, and to be used in combination with future RPAS (Remotely Piloted Aircraft Systems) for supporting a more flexible dynamic configuration of RPAS payloads.

  10. Instant Spring Tool Suite

    CERN Document Server

    Chiang, Geoff

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. A tutorial guide that walks you through how to use the features of Spring Tool Suite using well defined sections for the different parts of Spring.Instant Spring Tool Suite is for novice to intermediate Java developers looking to get a head-start in enterprise application development using Spring Tool Suite and the Spring framework. If you are looking for a guide for effective application development using Spring Tool Suite, then this book is for you.

  11. Space suit bioenergetics: framework and analysis of unsuited and suited activity.

    Science.gov (United States)

    Carr, Christopher E; Newman, Dava J

    2007-11-01

    Metabolic costs limit the duration and intensity of extravehicular activity (EVA), an essential component of future human missions to the Moon and Mars. Energetics Framework: We present a framework for comparison of energetics data across and between studies. This framework, applied to locomotion, differentiates between muscle efficiency and energy recovery, two concepts often confused in the literature. The human run-walk transition in Earth gravity occurs at the point for which energy recovery is approximately the same for walking and running, suggesting a possible role for recovery in gait transitions. Muscular Energetics: Muscle physiology limits the overall efficiency by which chemical energy is converted through metabolism to useful work. Unsuited Locomotion: Walking and running use different methods of energy storage and release. These differences contribute to the relative changes in the metabolic cost of walking and running as gravity is varied, with the metabolic cost of locomoting at a given velocity changing in proportion to gravity for running and less than in proportion for walking. Space Suits: Major factors affecting the energetic cost of suited movement include suit pressurization, gravity, velocity, surface slope, and space suit configuration. Apollo lunar surface EVA traverse metabolic rates, while unexpectedly low, were higher than other activity categories. The Lunar Roving Vehicle facilitated even lower metabolic rates, thus longer duration EVAs. Muscles and tendons act like springs during running; similarly, longitudinal pressure forces in gas pressure space suits allow spring-like storage and release of energy when suits are self-supporting.

  12. Planetary Suit Hip Bearing Model for Predicting Design vs. Performance

    Science.gov (United States)

    Cowley, Matthew S.; Margerum, Sarah; Harvil, Lauren; Rajulu, Sudhakar

    2011-01-01

    , the suited performance trends were comparable between the model and the suited subjects. With the three off-nominal bearing configurations compared to the nominal bearing configurations, human subjects showed decreases in hip flexion of 64%, 6%, and 13% and in hip abduction of 59%, 2%, and 20%. Likewise the solid model showed decreases in hip flexion of 58%, 1%, and 25% and in hip abduction of 56%, 0%, and 30%, under the same condition changes from the nominal configuration. Differences seen between the model predictions and the human subject performance data could be attributed to the model lacking dynamic elements and performing kinematic analysis only, the level of fit of the subjects with the suit, the levels of the subject s suit experience.

  13. Relationships between levels of motor coordination, attention and physical activity in children: The mediation model

    Directory of Open Access Journals (Sweden)

    Jakub Kokštejn

    2012-12-01

    Full Text Available BACKGROUND: Current findings suggest that physical activity of children with developmental difficulties may be limited by low level of motor coordination. Motor difficulties are often connected with children suffering from attention deficit disorder. OBJECTIVE: The aim of the study was to find out the level of physical activity (PA in older school-age children with motor difficulties (MD in comparison with children without MD and to reveal possible mediate impact on attention between the level of motor skills and PA in children of this age. METHODS: Participants were divided into two groups: 15 children with MD (age 13.7 ± 1.6 years and 27 children without MD (age 13.3 ± 1.4 years. Motor functions were assessed by means of test battery MABC-2, weekly physical activity by means of Actigraph accelerometer and attention by both d2 and numeric square tests. To estimate the mediation of the attention level we have used Baron's & Kenny's (1986 analysis. RESULTS: In most of the indicators of PA, children with MD reached lower value than those without MD. The differences of statistical significance were found in the number of steps per week and weekdays (d = 0.50 and 0.64 respectively and in PA of a very high intensity (d =2 .00 in boys with and without MD. In girls with MD we have found out significantly less time spent in vigorous intensity PA (d = 0.86. The study results support the hypothesis of developmental motor deficits to be a risk factor for PA in older school-age children. Significant mediation effect of concentration of attention in the relationship between the level of motor skills and PA was observed in three cases - in the relationship between gross motor skills on the one hand, and energy expenditure per week and weekdays, and vigorous intensity PA per week on the other. The amount of mediation effect of attention concentration ranged between 12-22%. CONCLUSION: The study has indicated that children's participation in PA can be

  14. Mediating role of activity level in the depressive realism effect.

    Science.gov (United States)

    Blanco, Fernando; Matute, Helena; A Vadillo, Miguel

    2012-01-01

    Several classic studies have concluded that the accuracy of identifying uncontrollable situations depends heavily on depressive mood. Nondepressed participants tend to exhibit an optimistic illusion of control, whereas depressed participants tend to better detect a lack of control. Recently, we suggested that the different activity levels (measured as the probability of responding during a contingency learning task) exhibited by depressed and nondepressed individuals is partly responsible for this effect. The two studies presented in this paper provide further support for this mediational hypothesis, in which mood is the distal cause of the illusion of control operating through activity level, the proximal cause. In Study 1, the probability of responding, P(R), was found to be a mediator variable between the depressive symptoms and the judgments of control. In Study 2, we intervened directly on the mediator variable: The P(R) for both depressed and nondepressed participants was manipulated through instructions. Our results confirm that P(R) manipulation produced differences in the participants' perceptions of uncontrollability. Importantly, the intervention on the mediator variable cancelled the effect of the distal cause; the participants' judgments of control were no longer mood dependent when the P(R) was manipulated. This result supports the hypothesis that the so-called depressive realism effect is actually mediated by the probability of responding.

  15. Glycine facilitates gamma-glutamylcysteinylethyl ester-mediated increase in liver glutathione level.

    Science.gov (United States)

    Nishida, K; Ohta, Y; Ishiguro, I

    1997-08-27

    gamma-Glutamylcysteinylethyl ester (gamma-GCE) increases reduced glutathione (GSH) levels in GSH-depleted rat hepatocytes. Because glycine, a constituent of GSH, exists at 0.3 to 0.4 mM in rat plasma, we examined the influence of glycine added to the medium on the action of gamma-GCE to increase GSH levels in the rat hepatocytes. Glycine (0.2-0.8 mM) dose-dependently enhanced gamma-GCE-mediated increase in intracellular GSH levels with an increase in intracellular gamma-GCE levels. These results indicate that exogenous glycine facilitates gamma-GCE-mediated increase in intracellular GSH levels in rat hepatocytes possibly by enhancing the uptake of gamma-GCE into the cells.

  16. RAJA Performance Suite

    Energy Technology Data Exchange (ETDEWEB)

    2017-09-01

    The RAJA Performance Suite is designed to evaluate performance of the RAJA performance portability library on a wide variety of important high performance computing (HPC) algorithmic lulmels. These kernels assess compiler optimizations and various parallel programming model backends accessible through RAJA, such as OpenMP, CUDA, etc. The Initial version of the suite contains 25 computational kernels, each of which appears in 6 variants: Baseline SequcntiaJ, RAJA SequentiaJ, Baseline OpenMP, RAJA OpenMP, Baseline CUDA, RAJA CUDA. All variants of each kernel perform essentially the same mathematical operations and the loop body code for each kernel is identical across all variants. There are a few kernels, such as those that contain reduction operations, that require CUDA-specific coding for their CUDA variants. ActuaJ computer instructions executed and how they run in parallel differs depending on the parallel programming model backend used and which optimizations are perfonned by the compiler used to build the Perfonnance Suite executable. The Suite will be used primarily by RAJA developers to perform regular assessments of RAJA performance across a range of hardware platforms and compilers as RAJA features are being developed. It will also be used by LLNL hardware and software vendor panners for new defining requirements for future computing platform procurements and acceptance testing. In particular, the RAJA Performance Suite will be used for compiler acceptance testing of the upcoming CORAUSierra machine {initial LLNL delivery expected in late-2017/early 2018) and the CORAL-2 procurement. The Suite will aJso be used to generate concise source code reproducers of compiler and runtime issues we uncover so that we may provide them to relevant vendors to be fixed.

  17. Statistical Evaluation of Causal Factors Associated with Astronaut Shoulder Injury in Space Suits.

    Science.gov (United States)

    Anderson, Allison P; Newman, Dava J; Welsch, Roy E

    2015-07-01

    Shoulder injuries due to working inside the space suit are some of the most serious and debilitating injuries astronauts encounter. Space suit injuries occur primarily in the Neutral Buoyancy Laboratory (NBL) underwater training facility due to accumulated musculoskeletal stress. We quantitatively explored the underlying causal mechanisms of injury. Logistic regression was used to identify relevant space suit components, training environment variables, and anthropometric dimensions related to an increased propensity for space-suited injury. Two groups of subjects were analyzed: those whose reported shoulder incident is attributable to the NBL or working in the space suit, and those whose shoulder incidence began in active duty, meaning working in the suit could be a contributing factor. For both groups, percent of training performed in the space suit planar hard upper torso (HUT) was the most important predictor variable for injury. Frequency of training and recovery between training were also significant metrics. The most relevant anthropometric dimensions were bideltoid breadth, expanded chest depth, and shoulder circumference. Finally, record of previous injury was found to be a relevant predictor for subsequent injury. The first statistical model correctly identifies 39% of injured subjects, while the second model correctly identifies 68% of injured subjects. A review of the literature suggests this is the first work to quantitatively evaluate the hypothesized causal mechanisms of all space-suited shoulder injuries. Although limited in predictive capability, each of the identified variables can be monitored and modified operationally to reduce future impacts on an astronaut's health.

  18. Moms in motion: a group-mediated cognitive-behavioral physical activity intervention

    Directory of Open Access Journals (Sweden)

    Brawley Lawrence R

    2006-08-01

    Full Text Available Abstract Background When examining the prevalence of physical inactivity by gender and age, women over the age of 25 are at an increased risk for sedentary behavior. Childbearing and motherhood have been explored as one possible explanation for this increased risk. Post natal exercise studies to date demonstrate promising physical and psychological outcomes, however few physical activity interventions have been theory-driven and tailored to post natal exercise initiates. The purpose of this study was to compare the effects of a group-mediated cognitive behavioral intervention based upon social-cognitive theory and group dynamics (GMCB to a standard care postnatal exercise program (SE. Method A randomized, two-arm intervention design was used. Fifty-seven post natal women were randomized to one of two conditions: (1 a standard exercise treatment (SE and (2 a standard exercise treatment plus group-mediated cognitive behavioral intervention (GMCB. Participants in both conditions participated in a four-week intensive phase where participants received standard exercise training. In addition, GMCB participants received self-regulatory behavioral skills training via six group-mediated counseling sessions. Following the intensive phase, participants engaged in a four-week home-based phase of self-structured exercise. Measures of physical activity, barrier efficacy, and proximal outcome expectations were administered and data were analyzed using ANCOVA procedures. Results and discussion ANCOVA of change scores for frequency, minutes, and volume of physical activity revealed significant treatment effects over the intensive and home-based phases (p's Conclusion While both exercise programs resulted in improvements to exercise participation, the GMCB intervention produced greater improvement in overall physical activity, barrier efficacy and proximal outcome expectations.

  19. Apparatus for storing protective suits

    International Nuclear Information System (INIS)

    Englemann, H.J.; Koller, J.; Schrader, H.R.; Schade, G.; Pedrerol, J.

    1975-01-01

    Arrangements are described for storing one or more protective suits when contaminated on the outside. In order to permit a person wearing a contaminated suit to leave a contaminated area safely, and without contaminating the environment, it has hitherto been the practice for the suit to be passed through a 'lock' and cleansed under decontaminating showers whilst still being worn. This procedure is time wasting and not always completely effective, and it may be necessary to provide a second suit for use whilst the first suit is being decontaminated. Repeated decontamination may also result in undue wear and tear. The arrangements described provide a 'lock' chamber in which a contaminated suit may be stowed away without its interior becoming contaminated, thus allowing repeated use by persons donning and shedding it. (U.K.)

  20. Pharmacy settles suit.

    Science.gov (United States)

    1998-10-02

    A suit was filed by an HIV-positive man against a pharmacy that inadvertently disclosed his HIV status to his ex-wife and children. His ex-wife tried to use the information in a custody battle for their two children. The suit against the pharmacy was settled, but the terms of the settlement remain confidential.

  1. Mediating role of activity level in the depressive realism effect.

    Directory of Open Access Journals (Sweden)

    Fernando Blanco

    Full Text Available Several classic studies have concluded that the accuracy of identifying uncontrollable situations depends heavily on depressive mood. Nondepressed participants tend to exhibit an optimistic illusion of control, whereas depressed participants tend to better detect a lack of control. Recently, we suggested that the different activity levels (measured as the probability of responding during a contingency learning task exhibited by depressed and nondepressed individuals is partly responsible for this effect. The two studies presented in this paper provide further support for this mediational hypothesis, in which mood is the distal cause of the illusion of control operating through activity level, the proximal cause. In Study 1, the probability of responding, P(R, was found to be a mediator variable between the depressive symptoms and the judgments of control. In Study 2, we intervened directly on the mediator variable: The P(R for both depressed and nondepressed participants was manipulated through instructions. Our results confirm that P(R manipulation produced differences in the participants' perceptions of uncontrollability. Importantly, the intervention on the mediator variable cancelled the effect of the distal cause; the participants' judgments of control were no longer mood dependent when the P(R was manipulated. This result supports the hypothesis that the so-called depressive realism effect is actually mediated by the probability of responding.

  2. Mediating Role of Activity Level in the Depressive Realism Effect

    Science.gov (United States)

    Blanco, Fernando; Matute, Helena; A. Vadillo, Miguel

    2012-01-01

    Several classic studies have concluded that the accuracy of identifying uncontrollable situations depends heavily on depressive mood. Nondepressed participants tend to exhibit an optimistic illusion of control, whereas depressed participants tend to better detect a lack of control. Recently, we suggested that the different activity levels (measured as the probability of responding during a contingency learning task) exhibited by depressed and nondepressed individuals is partly responsible for this effect. The two studies presented in this paper provide further support for this mediational hypothesis, in which mood is the distal cause of the illusion of control operating through activity level, the proximal cause. In Study 1, the probability of responding, P(R), was found to be a mediator variable between the depressive symptoms and the judgments of control. In Study 2, we intervened directly on the mediator variable: The P(R) for both depressed and nondepressed participants was manipulated through instructions. Our results confirm that P(R) manipulation produced differences in the participants’ perceptions of uncontrollability. Importantly, the intervention on the mediator variable cancelled the effect of the distal cause; the participants’ judgments of control were no longer mood dependent when the P(R) was manipulated. This result supports the hypothesis that the so-called depressive realism effect is actually mediated by the probability of responding. PMID:23029435

  3. Comparing the Effect of Balance Training with and Without Suit Therapy on the Balance and the Gait Pattern of Patients with Parkinsin\\'s Disease

    Directory of Open Access Journals (Sweden)

    Majid Khodadadi

    2016-09-01

    Full Text Available Background & Objective: Parkinson's Disease  is a progressive neurologic disorder affecting the central nervous system. The objective of this study is to investigate the effect of balance training with and without suit therapy on the balance and the gait pattern of patients with Parkinson's Disease. Material & Methods: participants with Parkinson's Disease were divided  into three groups of control, with suit therapy, and without suit therapy. The control group received only pharmacotherapy, while the groups with and without suit therapy received eigh weeks balance training in addition to pharmacotherapy. The patient's balance  and gait  were evaluted by Berg and Tinetti scales, respectively at the pretest and posttest of this study. Result: The result of the study showed significant difference in balance between the three groups (P<0/05. The groups with and without suit therapy were significantly more effective than control group (P<0/05, but between groups with and without suit therapy no significant difference was observed (P=0/076. The result of the study also revealed significant difference in gait between the three groups (P<0/05. The groups with and without suit therapy were significantly more effective than control group (P<0/05, and the group with suit therapy was significantly more effective than the group without suit therapy (P<0/05. Conclusion: To do balance traning is better than not to do it, and balance training with suit therapy is better than without suit therapy

  4. Integrated Suit Test 1 - A Study to Evaluate Effects of Suit Weight, Pressure, and Kinematics on Human Performance during Lunar Ambulation

    Science.gov (United States)

    Gernhardt, Michael L.; Norcross, Jason; Vos, Jessica R.

    2008-01-01

    In an effort to design the next generation Lunar suit, NASA has initiated a series of tests aimed at understanding the human physiological and biomechanical affects of space suits under a variety of conditions. The first of these tests was the EVA Walkback Test (ICES 2007-01-3133). NASA-JSC assembled a multi-disciplinary team to conduct the second test of the series, titled Integrated Suit Test 1 (IST-1), from March 6 through July 24, 2007. Similar to the Walkback Test, this study was performed with the Mark III (MKIII) EVA Technology Demonstrator suit, a treadmill, and the Partial Gravity Simulator in the Space Vehicle Mock-Up Facility at Johnson Space Center. The data collected for IST-1 included metabolic rates, ground reaction forces, biomechanics, and subjective workload and controllability feedback on both suited and unsuited (shirt-sleeve) astronaut subjects. For IST-1 the center of gravity was controlled to a nearly perfect position while the weight, pressure and biomechanics (waist locked vs. unlocked) were varied individually to evaluate the effects of each on the ability to perform level (0 degree incline) ambulation in simulated Lunar gravity. The detailed test methodology and preliminary key findings of IST-1 are summarized in this report.

  5. Economic potential of the Rooiberg Group: volcanic rocks in the floor and roof of the Bushveld Complex

    Science.gov (United States)

    Schweitzer, J. K.; Hatton, C. J.; de Waal, S. A.

    1995-04-01

    Volcanic rocks of the Rooiberg Group are preserved in the floor and roof of the mafic Rustenburg Layered Suite of the Bushveld Complex. Field and geochemical characteristics of these volcanic rocks imply that they are genetically related to the Rustenburg Layered Suite. Four major ore-forming events are identified in the Rooiberg Group. The first phase was accompanied by volcanic hosted, fault controlled, hydrothermal copper mineralisation, which is found in the lowermost portion of the Rooiberg Group, underlying the Rustenburg Layered Suite. This type of mineralisation is tentatively linked to initial Rustenburg Layered Suite intrusions. Stratabound arsenic mineralisation that possibly formed in response to contact metamorphism, characterises the second phase, and occurred after extrusion of the Damwal Formation, possibly due to shallow granophyric intrusion. The third mineralising event occurred in response to contact metamorphism during the final stages of the Rustenburg Layered Suite, where especially Pb and Zn were introduced into the felsite roof rocks. This type of mineralisation affected the majority of the Rooiberg Group, but is most pronounced towards the contact with the Rustenburg Layered Suite. The fourth phase is restricted to the Rooiberg Group in the Nylstroom area and is linked to the granite intrusions of the Lebowa Granite Suite, from which Sn and F were introduced into the uppermost felsite succession. Mineralisation in the Rooiberg Group appears to be controlled by the character and intrusion level of the associated Bushveld magmas. Different styles of mineralisation in Rooiberg Group volcanic rocks are encountered at various stratigraphic levels. Major primary volcanogenic ore deposits appear to be absent.

  6. Intergenerational transmission of educational attainment: Three levels of parent-child communication as mediators.

    Science.gov (United States)

    Chi, Liping

    2013-04-01

    Although the intergenerational transmission of educational attainment has been confirmed by many researchers, its mechanism still remains controversial. Parent-child communication has been regarded as one of the important mediators. The present study primarily aimed to examine the potentially mediating role of parent-child communication in the transmission of educational attainment, based on a sample of 366 Chinese fifth and sixth graders. Parent-child communication was measured against the three levels of the parents' communication ability, the quality of the father-child and mother-child communications, and the relation between the two dyadic communications. The results duplicated the positive effect of parents' educational attainment on children's academic achievement. Moreover, it was found that parents' communication ability alone played a mediating role, and that the three levels of parent-child communication constructed a "mediator chain" between the parents' educational attainment and the children's academic achievement. Finally, the intergenerational transmission of educational attainment in China and the mediating role of the three levels of parent-child communication were discussed. © 2012 The Institute of Psychology, Chinese Academy of Sciences and Blackwell Publishing Asia Pty Ltd.

  7. Social influence in computer-mediated communication : The effects of anonymity on group behavior

    NARCIS (Netherlands)

    Postmes, T; Spears, R; Sakhel, K; de Groot, D

    2001-01-01

    Two studies examined hypotheses derived from a Social Identity model of Deindividuation Effects (SIDE) as applied to social influence in computer-mediated communication (CMC) in groups. This model predicts that anonymity can increase social influence if a common group identity is salient. In a first

  8. Improved airline-type supplied-air plastic suit. [For personnel protection against inhalation of airborne plutonium and tritium

    Energy Technology Data Exchange (ETDEWEB)

    Jolley, L. Jr.; Zippler, D.B.; Cofer, C.H.; Harper, J.A.

    1978-06-01

    Two piece supplied-air plastic suits are used extensively at the Savannah River Plant for personnel protection against inhalation of airborne plutonium and tritium. Worker comfort and noise level problems gave impetus to development of an improved suit and aid distribution system. The resulting plastic suit and development work are discussed. The plastic suit unit cost is less than $20, the hearing zone noise level is less than 75 dBA, protection factors exceed 10,000, and user comfort is approved. This suit is expected to meet performance requirements for unrestricted use.

  9. Results from Carbon Dioxide Washout Testing Using a Suited Manikin Test Apparatus with a Space Suit Ventilation Test Loop

    Science.gov (United States)

    Chullen, Cinda; Conger, Bruce; McMillin, Summer; Vonau, Walt; Kanne, Bryan; Korona, Adam; Swickrath, Mike

    2016-01-01

    NASA is developing an advanced portable life support system (PLSS) to meet the needs of a new NASA advanced space suit. The PLSS is one of the most critical aspects of the space suit providing the necessary oxygen, ventilation, and thermal protection for an astronaut performing a spacewalk. The ventilation subsystem in the PLSS must provide sufficient carbon dioxide (CO2) removal and ensure that the CO2 is washed away from the oronasal region of the astronaut. CO2 washout is a term used to describe the mechanism by which CO2 levels are controlled within the helmet to limit the concentration of CO2 inhaled by the astronaut. Accumulation of CO2 in the helmet or throughout the ventilation loop could cause the suited astronaut to experience hypercapnia (excessive carbon dioxide in the blood). A suited manikin test apparatus (SMTA) integrated with a space suit ventilation test loop was designed, developed, and assembled at NASA in order to experimentally validate adequate CO2 removal throughout the PLSS ventilation subsystem and to quantify CO2 washout performance under various conditions. The test results from this integrated system will be used to validate analytical models and augment human testing. This paper presents the system integration of the PLSS ventilation test loop with the SMTA including the newly developed regenerative Rapid Cycle Amine component used for CO2 removal and tidal breathing capability to emulate the human. The testing and analytical results of the integrated system are presented along with future work.

  10. Specifications and test procedures for airline-type supplied-air suits

    International Nuclear Information System (INIS)

    Revoir, W.H.; Pritchard, J.A.; Davis, T.O.; Richards, C.P.; Wheat, L.D.

    1975-05-01

    Procedures and requirements have been established to permit airline-type supplied-air suits needed by contractors of the Energy Research and Development Administration to be tested for performance by the Respirator Research and Development Section, Industrial Hygiene Group, of the Los Alamos Scientific Laboratory, and to have the adequacy of the performance of these devices evaluated by the Los Alamos Scientific Laboratory Respirator Advisory Committee. Test equipment, test methods, and performance criteria for airline-type supplied-air suits are prescribed. (U.S.)

  11. Can we get some cooperation around here? The mediating role of group norms on the relationship between team personality and individual helping behaviors.

    Science.gov (United States)

    Gonzalez-Mulé, Erik; DeGeest, David S; McCormick, Brian W; Seong, Jee Young; Brown, Kenneth G

    2014-09-01

    Drawing on the group-norms theory of organizational citizenship behaviors and person-environment fit theory, we introduce and test a multilevel model of the effects of additive and dispersion composition models of team members' personality characteristics on group norms and individual helping behaviors. Our model was tested using regression and random coefficients modeling on 102 research and development teams. Results indicated that high mean levels of extraversion are positively related to individual helping behaviors through the mediating effect of cooperative group norms. Further, low variance on agreeableness (supplementary fit) and high variance on extraversion (complementary fit) promote the enactment of individual helping behaviors, but only the effects of extraversion were mediated by cooperative group norms. Implications of these findings for theories of helping behaviors in teams are discussed. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  12. Mediating effects of group cohesion on physical activity and diet in women of color: health is power.

    Science.gov (United States)

    Lee, Rebecca E; O'Connor, Daniel P; Smith-Ray, Renae; Mama, Scherezade K; Medina, Ashley V; Reese-Smith, Jacqueline Y; Banda, Jorge A; Layne, Charles S; Brosnan, Marcella; Cubbin, Catherine; McMillan, Tracy; Estabrooks, Paul A

    2012-01-01

    To determine the effects and mediating factors of a physical activity (PA) or vegetable and fruit (VF) group cohesion intervention. Longitudinal design. Harris County and Travis County, Texas. Community-dwelling African-American and Hispanic or Latina women. Three hundred ten women were randomized to a PA (n  =  204) or VF (n  =  106) intervention group. Women met in groups six times over the course of 6 months and were exposed to a group cohesion intervention to promote walking or to increase VF consumption. Women completed the International PA Questionnaire, National Cancer Institute VF and fat screeners, PA Group Environment Questionnaire, and 7-day accelerometer protocol at baseline and post-intervention. The direct and mediated effects of the intervention on outcomes were evaluated using a mediational chain model, controlling for baseline values and covariates using path analysis. Women were middle aged (mean  =  44.4 years) and overweight or obese (mean body mass index  =  34.0 kg/m(2)). PA increased and fat consumption decreased for both groups, whereas VF consumption increased for women in VF group only (all p psychological and physical health benefits for African-American and Hispanic or Latina women, but refinement of measures and intervention delivery is needed to determine whether hypothesized mediational pathways are valid.

  13. Durable Suit Bladder with Improved Water Permeability for Pressure and Environment Suits

    Science.gov (United States)

    Bue, Grant C.; Kuznetz, Larry; Orndoff, Evelyne; Tang, Henry; Aitchison, Lindsay; Ross, Amy

    2009-01-01

    Water vapor permeability is shown to be useful in rejecting heat and managing moisture accumulation in launch-and-entry pressure suits. Currently this is accomplished through a porous Gortex layer in the Advanced Crew and Escape Suit (ACES) and in the baseline design of the Constellation Suit System Element (CSSE) Suit 1. Non-porous dense monolithic membranes (DMM) that are available offer potential improvements for water vapor permeability with reduced gas leak. Accordingly, three different pressure bladder materials were investigated for water vapor permeability and oxygen leak: ElasthaneTM 80A (thermoplastic polyether urethane) provided from stock polymer material and two custom thermoplastic polyether urethanes. Water vapor, carbon dioxide and oxygen permeability of the DMM's was measured in a 0.13 mm thick stand-alone layer, a 0.08 mm and 0.05 mm thick layer each bonded to two different nylon and polyester woven reinforcing materials. Additional water vapor permeability and mechanical compression measurements were made with the reinforced 0.05 mm thick layers, further bonded with a polyester wicking and overlaid with moistened polyester fleece thermal underwear .This simulated the pressure from a supine crew person. The 0.05 mm thick nylon reinforced sample with polyester wicking layer was further mechanically tested for wear and abrasion. Concepts for incorporating these materials in launch/entry and Extravehicular Activity pressure suits are presented.

  14. Accounting for sex differences in PTSD: A multi-variable mediation model

    DEFF Research Database (Denmark)

    Christiansen, Dorte M.; Hansen, Maj

    2015-01-01

    methods that were not ideally suited to test for mediation effects. Prior research has identified a number of individual risk factors that may contribute to sex differences in PTSD severity, although these cannot fully account for the increased symptom levels in females when examined individually....... Objective: The present study is the first to systematically test the hypothesis that a combination of pre-, peri-, and posttraumatic risk factors more prevalent in females can account for sex differences in PTSD severity. Method: The study was a quasi-prospective questionnaire survey assessing PTSD...... cognitions about self and the world, and feeling let down. These variables were included in the model as potential mediators. The combination of risk factors significantly mediated the association between sex and PTSD severity, accounting for 83% of the association. Conclusion: The findings suggest...

  15. The Los Alamos suite of relativistic atomic physics codes

    International Nuclear Information System (INIS)

    Fontes, C J; Zhang, H L; Jr, J Abdallah; Clark, R E H; Kilcrease, D P; Colgan, J; Cunningham, R T; Hakel, P; Magee, N H; Sherrill, M E

    2015-01-01

    The Los Alamos suite of relativistic atomic physics codes is a robust, mature platform that has been used to model highly charged ions in a variety of ways. The suite includes capabilities for calculating data related to fundamental atomic structure, as well as the processes of photoexcitation, electron-impact excitation and ionization, photoionization and autoionization within a consistent framework. These data can be of a basic nature, such as cross sections and collision strengths, which are useful in making predictions that can be compared with experiments to test fundamental theories of highly charged ions, such as quantum electrodynamics. The suite can also be used to generate detailed models of energy levels and rate coefficients, and to apply them in the collisional-radiative modeling of plasmas over a wide range of conditions. Such modeling is useful, for example, in the interpretation of spectra generated by a variety of plasmas. In this work, we provide a brief overview of the capabilities within the Los Alamos relativistic suite along with some examples of its application to the modeling of highly charged ions. (paper)

  16. Chemical groups and structural characterization of lignin via thiol-mediated demethylation

    Science.gov (United States)

    Lihong Hu; Hui Pan; Yonghong Zhou; Chung-Yun Hse; Chengguo Liu; Baofang Zhang; Bin Xu

    2014-01-01

    A new approach to increase the reactivity of lignin by thiol-mediated demethylation was investigated in this study. Demethylated lignin was characterized by the changes in its hydroxyl and methoxyl groups, molecular weight, and other properties using titration and spectroscopy methods including FT-IR, 1H NMR, UV,and GPC. The total...

  17. Development of Power Assisting Suit

    Science.gov (United States)

    Yamamoto, Keijiro; Ishii, Mineo; Hyodo, Kazuhito; Yoshimitsu, Toshihiro; Matsuo, Takashi

    In order to realize a wearable power assisting suit for assisting a nurse to carry a patient in her arms, the power supply and control systems of the suit have to be miniaturized, and it has to be wireless and pipeline-less. The new wearable suit consists of shoulders, arms, back, waist and legs units to be fitted on the nurse's body. The arms, waist and legs have new pneumatic rotary actuators driven directly by micro air pumps supplied by portable Ni-Cd batteries. The muscle forces are sensed by a new muscle hardness sensor utilizing a sensing tip mounted on a force sensing film device. An embedded microcomputer is used for the calculations of control signals. The new wearable suit was applied practically to a human body and a series of movement experiments that weights in the arms were held and taken up and down was performed. Each unit of the suit could transmit assisting torque directly to each joint verifying its practicability.

  18. Using a Virtual Class to Demonstrate Computer-Mediated Group Dynamics Concepts

    Science.gov (United States)

    Franz, Timothy M.; Vicker, Lauren A.

    2010-01-01

    We report about an active learning demonstration designed to use a virtual class to present computer-mediated group communication course concepts to show that students can learn about these concepts in a virtual class. We designated 1 class period as a virtual rather than face-to-face class, when class members "attended" virtually using…

  19. Space Suit Joint Torque Testing

    Science.gov (United States)

    Valish, Dana J.

    2011-01-01

    In 2009 and early 2010, a test was performed to quantify the torque required to manipulate joints in several existing operational and prototype space suits in an effort to develop joint torque requirements appropriate for a new Constellation Program space suit system. The same test method was levied on the Constellation space suit contractors to verify that their suit design meets the requirements. However, because the original test was set up and conducted by a single test operator there was some question as to whether this method was repeatable enough to be considered a standard verification method for Constellation or other future space suits. In order to validate the method itself, a representative subset of the previous test was repeated, using the same information that would be available to space suit contractors, but set up and conducted by someone not familiar with the previous test. The resultant data was compared using graphical and statistical analysis and a variance in torque values for some of the tested joints was apparent. Potential variables that could have affected the data were identified and re-testing was conducted in an attempt to eliminate these variables. The results of the retest will be used to determine if further testing and modification is necessary before the method can be validated.

  20. Evaluating Suit Fit Using Performance Degradation

    Science.gov (United States)

    Margerum, Sarah E.; Cowley, Matthew; Harvill, Lauren; Benson, Elizabeth; Rajulu, Sudhakar

    2011-01-01

    The Mark III suit has multiple sizes of suit components (arm, leg, and gloves) as well as sizing inserts to tailor the fit of the suit to an individual. This study sought to determine a way to identify the point an ideal suit fit transforms into a bad fit and how to quantify this breakdown using mobility-based physical performance data. This study examined the changes in human physical performance via degradation of the elbow and wrist range of motion of the planetary suit prototype (Mark III) with respect to changes in sizing and as well as how to apply that knowledge to suit sizing options and improvements in suit fit. The methods implemented in this study focused on changes in elbow and wrist mobility due to incremental suit sizing modifications. This incremental sizing was within a range that included both optimum and poor fit. Suited range of motion data was collected using a motion analysis system for nine isolated and functional tasks encompassing the elbow and wrist joints. A total of four subjects were tested with motions involving both arms simultaneously as well as the right arm only. The results were then compared across sizing configurations. The results of this study indicate that range of motion may be used as a viable parameter to quantify at what stage suit sizing causes a detriment in performance; however the human performance decrement appeared to be based on the interaction of multiple joints along a limb, not a single joint angle. The study was able to identify a preliminary method to quantify the impact of size on performance and to develop a means to gauge tolerances around optimal size. More work is needed to improve the assessment of optimal fit and to compensate for multiple joint interactions.

  1. Specific emotions as mediators of the effect of intergroup contact on prejudice: findings across multiple participant and target groups.

    Science.gov (United States)

    Seger, Charles R; Banerji, Ishani; Park, Sang Hee; Smith, Eliot R; Mackie, Diane M

    2017-08-01

    Emotions are increasingly being recognised as important aspects of prejudice and intergroup behaviour. Specifically, emotional mediators play a key role in the process by which intergroup contact reduces prejudice towards outgroups. However, which particular emotions are most important for prejudice reduction, as well as the consistency and generality of emotion-prejudice relations across different in-group-out-group relations, remain uncertain. To address these issues, in Study 1 we examined six distinct positive and negative emotions as mediators of the contact-prejudice relations using representative samples of U.S. White, Black, and Asian American respondents (N = 639). Admiration and anger (but not other emotions) were significant mediators of the effects of previous contact on prejudice, consistently across different perceiver and target ethnic groups. Study 2 examined the same relations with student participants and gay men as the out-group. Admiration and disgust mediated the effect of past contact on attitude. The findings confirm that not only negative emotions (anger or disgust, based on the specific types of threat perceived to be posed by an out-group), but also positive, status- and esteem-related emotions (admiration) mediate effects of contact on prejudice, robustly across several different respondent and target groups.

  2. Inherent work suit buoyancy distribution: effects on lifejacket self-righting performance.

    Science.gov (United States)

    Barwood, Martin J; Long, Geoffrey M; Lunt, Heather; Tipton, Michael J

    2014-09-01

    Accidental immersion in cold water is an occupational risk. Work suits and life jackets (LJ) should work effectively in combination to keep the airway clear of the water (freeboard) and enable self-righting. We hypothesized that inherent buoyancy, in the suit or LJ, would be beneficial for enabling freeboard, but its distribution may influence LJ self-righting. Six participants consented to complete nine immersions. Suits and LJ tested were: flotation suit (FLOAT; 85 N inherent buoyancy); oilskins 1 (OS-1) and 2 (OS-2), both with no inherent buoyancy; LJs (inherent buoyancy/buoyancy after inflation/total buoyancy), LJ-1 50/150/200 N, LJ-2 0/290/290 N, LJ-3 80/190/270 N. Once dressed, the subject entered an immersion pool where uninflated freeboard, self-righting performance, and inflated freeboard were measured. Data were compared using Friedman's test to the 0.05 alpha level. All suits and LJs enabled uninflated and inflated freeboard, but differences were seen between the suits and LJs. Self-righting was achieved on 43 of 54 occasions, irrespective of suit or LJ. On all occasions that self-righting was not achieved, this occurred in an LJ that included inherent buoyancy (11/54 occasions). Of these 11 failures, 8 occurred (73% of occasions) when the FLOAT suit was being worn. LJs that included inherent buoyancy, that are certified as effective on their own, worked less effectively from the perspective of self-righting in combination with a work suit that also included inherent buoyancy. Equipment that is approved for use in the workplace should be tested in combination to ensure adequate performance in an emergency scenario.

  3. Stepwise latent class models for explaining group-level putcomes using discrete individual-level predictors

    NARCIS (Netherlands)

    Bennink, Margot; Croon, M.A.; Vermunt, J.K.

    2015-01-01

    Explaining group-level outcomes from individual-level predictors requires aggregating the individual-level scores to the group level and correcting the group-level estimates for measurement errors in the aggregated scores. However, for discrete variables it is not clear how to perform the

  4. A transitional alkalic dolerite dike suite of Mesozoic age in Southeastern New England

    Science.gov (United States)

    Hermes, O. Don; Rao, J. M.; Dickenson, M. P.; Pierce, T. A.

    1984-12-01

    Dike rocks from the New England platform of Rhode Island and adjacent Massachusetts consist of premetamorphic and post-metamorphic suites. The older group includes metamorphosed dolerite, minette, and schistose dioritic rocks. Post-metamorphic dikes consist of dolerite and sparse monchiquite. The post-metamorphic dolerites are of comparable age to the Eastern North American dolerite suite associated with the Mesozoic basins along the eastern seaboard of North America. However, the southeastern New England dolerites exhibit mineralogy and chemistry more typical of a transitional alkalic suite compared to the more subalkalic tholeiitic dolerites of the Eastern North American suite. Both suites are compatible with a rift tectonic setting, but the more alkalic dolerites may represent a deeper source of small volume melts compared to the Eastern North American dolerites. These more alkaline melts may have concentrated at local centers, or they may be typical of flank dolerites as opposed to the less alkalic varieties that occur within the central axial rift.

  5. Surface-Level Diversity and Decision-Making in Groups: When Does Deep-Level Similarity Help?

    OpenAIRE

    2006-01-01

    Abstract We examined how surface-level diversity (based on race) and deep-level similarities influenced three-person decision-making groups on a hidden-profile task. Surface-level homogeneous groups perceived their information to be less unique and spent less time on the task than surface-level diverse groups. When the groups were given the opportunity to learn about their deep-level similarities prior to t...

  6. Exploring the disruptive effects of psychopathy and aggression on group processes and group effectiveness.

    Science.gov (United States)

    Baysinger, Michael A; Scherer, Kelly T; LeBreton, James M

    2014-01-01

    The present research examines the influence of implicit and explicit personality characteristics on group process and effectiveness. Individuals from 112 groups participated in 2 problem-solving tasks and completed measures of group process and effectiveness. Results indicated that groups characterized by higher levels of psychopathy and implicit aggression tended to have more dysfunctional interactions and negative perceptions of the group. In addition, task participation and negative socioemotional behaviors fully mediated the relationship between group personality traits and group commitment and cohesion, and negative socioemotional behaviors fully mediated the relationship between group personality and performance on both tasks. Implications of antisocial traits for group interactions and performance, as well as for future theory and research, are discussed. PsycINFO Database Record (c) 2014 APA, all rights reserved

  7. Adobe Creative Suite 4 Bible

    CERN Document Server

    Padova, Ted

    2009-01-01

    As one of the few books to cover integration and workflow issues between Photoshop, Illustrator, InDesign, GoLive, Acrobat, and Version Cue, this comprehensive reference is the one book that Creative Suite users need; Two well-known and respected authors cover topics such as developing consistent color-managed workflows, moving files among the Creative Suite applications, preparing files for print or the Web, repurposing documents, and using the Creative Suite with Microsoft Office documents; More than 1,200 pages are packed with valuable advice and techniques for tackling common everyday issu

  8. G SUIT FOR EDUCATION AS AN ENVIRONMENT FOR STUDENTS OF EDUCATIONAL PRACTICES

    OpenAIRE

    Olena Glazunova; Olena Kuzminska; Tetyana Voloshyna; Taisia Sayapina; Valentyna Korolchuk

    2017-01-01

    Materials article analyzes the opportunities and benefits of using cloud services G Suite (Google Apps) during the practical training of students. In the course of the study, an e-environment based on G Suit for Education was developed and its use for effective organization of information technology practice training. A model of e-learning environment for organizing group project work in Google Classroom-based training has been built. The design methodology is grounded as one of the most effe...

  9. Item response theory at subject- and group-level

    NARCIS (Netherlands)

    Tobi, Hilde

    1990-01-01

    This paper reviews the literature about item response models for the subject level and aggregated level (group level). Group-level item response models (IRMs) are used in the United States in large-scale assessment programs such as the National Assessment of Educational Progress and the California

  10. DYNA3D/ParaDyn Regression Test Suite Inventory

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Jerry I. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-09-01

    The following table constitutes an initial assessment of feature coverage across the regression test suite used for DYNA3D and ParaDyn. It documents the regression test suite at the time of preliminary release 16.1 in September 2016. The columns of the table represent groupings of functionalities, e.g., material models. Each problem in the test suite is represented by a row in the table. All features exercised by the problem are denoted by a check mark (√) in the corresponding column. The definition of “feature” has not been subdivided to its smallest unit of user input, e.g., algorithmic parameters specific to a particular type of contact surface. This represents a judgment to provide code developers and users a reasonable impression of feature coverage without expanding the width of the table by several multiples. All regression testing is run in parallel, typically with eight processors, except problems involving features only available in serial mode. Many are strictly regression tests acting as a check that the codes continue to produce adequately repeatable results as development unfolds; compilers change and platforms are replaced. A subset of the tests represents true verification problems that have been checked against analytical or other benchmark solutions. Users are welcomed to submit documented problems for inclusion in the test suite, especially if they are heavily exercising, and dependent upon, features that are currently underrepresented.

  11. 28 CFR 36.503 - Suit by the Attorney General.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Suit by the Attorney General. 36.503... discretion, the Attorney General may commence a civil action in any appropriate United States district court if the Attorney General has reasonable cause to believe that— (a) Any person or group of persons is...

  12. Hybrid Enhanced Epidermal SpaceSuit Design Approaches

    Science.gov (United States)

    Jessup, Joseph M.

    A Space suit that does not rely on gas pressurization is a multi-faceted problem that requires major stability controls to be incorporated during design and construction. The concept of Hybrid Epidermal Enhancement space suit integrates evolved human anthropomorphic and physiological adaptations into its functionality, using commercially available bio-medical technologies to address shortcomings of conventional gas pressure suits, and the impracticalities of MCP suits. The prototype HEE Space Suit explored integumentary homeostasis, thermal control and mobility using advanced bio-medical materials technology and construction concepts. The goal was a space suit that functions as an enhanced, multi-functional bio-mimic of the human epidermal layer that works in attunement with the wearer rather than as a separate system. In addressing human physiological requirements for design and construction of the HEE suit, testing regimes were devised and integrated into the prototype which was then subject to a series of detailed tests using both anatomical reproduction methods and human subject.

  13. Comparison of Effectiveness of Adeli Suit Therapy and Bobath Approach on Gross Motor Function Improvement in Children with Cerebral Palsy

    Directory of Open Access Journals (Sweden)

    Mohammad Khayat-Zadeh-Mahani

    2010-07-01

    Full Text Available Objective: The aim of this study was to determine the effectiveness of Adeli Suit Therapy (AST and Bobath approach on improvement of gross motor function in children with cerebral palsy aged 4 to 11 years of old. Materials & Methods: In this experimental and randomized clinical trial study, 24 children with cerebral palsy were selected simply according to inclusive and exclusive criteria from patients referred to ValieAsr rehabilitation center and then assigned into two Adeli Suit Thrapy and Bobath groups by simple random method. Period of therapeutic intervention was 36 sessions, 3 times per week for both groups. Assessment tool was Gross Motor Function Measure test (GMFM–66. Data was analyzed by Kolmogroff Smirnoff, Independent T-test and ANOVA for repeated measurements. Results: After intervention, the gross motor function improved significantly in both groups (P<0.001. Follow up study revealed significant improvement of functions in Adeli Suit group (P=0.007 and significant regression of functions in Bobath group (P=0.004. There was no significant difference, just after the intervention, between two groups (P=0.598, but there was significant difference between two groups at follow up assessments (P=0.002. Conclusion: Both Adeli Suit and Bobath approaches are effective in improvement of gross motor functions in children with cerebral palsy during the therapeutic sessions. At follow up study, the Adeli Suit group, were still improving their function whereas the Bobath group regressed.

  14. Student groups as learning entities : The effect of group diversity and teamwork quality on groups' cognitive complexity

    NARCIS (Netherlands)

    Curseu, P.L.; Pluut, H.

    2013-01-01

    Collaborative learning has important group-level benefits, yet most studies in higher education only focus on individual benefits of collaborative learning experiences. This study extends these insights by testing a model in which teamwork quality mediates the impact of several compositional

  15. Tier-3 Monitoring Software Suite (T3MON) proposal

    CERN Document Server

    Andreeva, J; The ATLAS collaboration; Klimentov, A; Korenkov, V; Oleynik, D; Panitkin, S; Petrosyan, A

    2011-01-01

    The ATLAS Distributed Computing activities concentrated so far in the “central” part of the computing system of the experiment, namely the first 3 tiers (CERN Tier0, the 10 Tier1s centres and the 60+ Tier2s). This is a coherent system to perform data processing and management on a global scale and host (re)processing, simulation activities down to group and user analysis. Many ATLAS Institutes and National Communities built (or have plans to build) Tier-3 facilities. The definition of Tier-3 concept has been outlined (REFERENCE). Tier-3 centres consist of non-pledged resources mostly dedicated for the data analysis by the geographically close or local scientific groups. Tier-3 sites comprise a range of architectures and many do not possess Grid middleware, which would render application of Tier-2 monitoring systems useless. This document describes a strategy to develop a software suite for monitoring of the Tier3 sites. This software suite will enable local monitoring of the Tier3 sites and the global vie...

  16. Special class-action suit (without obligation to belong to the group in question) is considered highly objectionable

    International Nuclear Information System (INIS)

    Lippold, K.

    1980-01-01

    Together with the Hessian Act on Nature Protection, special class-action suit has been introduced for the first time in a state of the Federal Republic of Germany. The author gives a reason for his negative opinion by saying that the Federal legislator has definitely been against its introduction into the Federal Act on Nature Protection. It is contrary to the system of individual legal protection. Investment decisions to be made by industry and administration are delayed and activities of the administration are replaced by the jurisdiction. Since suggestions and objections raised by the associations find their way into the decision-making process, controlling by filing suit is unnecessary after the issuance of this decision. According to that, the Association of the Towns and Cities of Hesse will file a complaint of unconstitutionality. Trade associations are urging to amend this law. (HSCH) [de

  17. Special class-action suit (without obligation to belong to the group in question) is considered highly objectionable

    Energy Technology Data Exchange (ETDEWEB)

    Lippold, K.

    1980-01-01

    Together with the Hessian Act on Nature Protection, special class-action suit has been introduced for the first time in a state of the Federal Republic of Germany. The author gives a reason for his negative opinion by saying that the Federal legislator has definitely been against its introduction into the Federal Act on Nature Protection. It is contrary to the system of individual legal protection. Investment decisions to be made by industry and administration are delayed and activities of the administration are replaced by the jurisdiction. Since suggestions and objections raised by the associations find their way into the decision-making process, controlling by filing suit is unnecessary after the issuance of this decision. According to that, the Association of the Towns and Cities of Hesse will file a complaint of unconstitutionality. Trade associations are urging to amend this law.

  18. The BRITNeY Suite Animation Tool

    DEFF Research Database (Denmark)

    Westergaard, Michael; Lassen, Kristian Bisgaard

    2006-01-01

    This paper describes the BRITNeY suite, a tool which enables users to create visualizations of formal models. BRITNeY suite is integrated with CPN Tools, and we give an example of how to extend a simple stop-and-wait protocol with a visualization in the form of message sequence charts. We also sh...... examples of animations created during industrial projects to give an impression of what is possible with the BRITNeY suite....

  19. Walking a mile in another's shoes: The impact of wearing an Age Suit.

    Science.gov (United States)

    Lavallière, Martin; D'Ambrosio, Lisa; Gennis, Angelina; Burstein, Arielle; Godfrey, Kathryn M; Waerstad, Hilde; Puleo, Rozanne M; Lauenroth, Andreas; Coughlin, Joseph F

    2017-01-01

    The "Age Suit" described in this article was developed to enable future designers, business leaders, and engineers to experience navigating the world as many older adults must. Tools such as this Age Suit offer the opportunity to "walk a mile" in another's shoes to develop empathy that can result in better design of spaces, goods, and services to meet the needs of a rapidly growing older population. This work first examined, through a series of clinical tests, whether younger adults' physical capacities were reduced in a direction consistent with aging by wearing a suit developed by the MIT AgeLab. An experiential learning task was then completed with the suit to understand its impact on completion of an instrumental activity of daily living. Results showed that younger adults wearing the suit experienced changes in task performance consistent with expected changes associated with aging. Participants' self-reports from the experiential learning task indicated that they were able to empathize with older adults regarding some issues they face while completing a grocery shopping task. Future research with the suit should involve a wider range of individuals from the population and examine what effect participants' levels of fitness have on the experience of wearing the suit.

  20. The CMSSW benchmarking suite: Using HEP code to measure CPU performance

    International Nuclear Information System (INIS)

    Benelli, G

    2010-01-01

    The demanding computing needs of the CMS experiment require thoughtful planning and management of its computing infrastructure. A key factor in this process is the use of realistic benchmarks when assessing the computing power of the different architectures available. In recent years a discrepancy has been observed between the CPU performance estimates given by the reference benchmark for HEP computing (SPECint) and actual performances of HEP code. Making use of the CPU performance tools from the CMSSW performance suite, comparative CPU performance studies have been carried out on several architectures. A benchmarking suite has been developed and integrated in the CMSSW framework, to allow computing centers and interested third parties to benchmark architectures directly with CMSSW. The CMSSW benchmarking suite can be used out of the box, to test and compare several machines in terms of CPU performance and report with the wanted level of detail the different benchmarking scores (e.g. by processing step) and results. In this talk we describe briefly the CMSSW software performance suite, and in detail the CMSSW benchmarking suite client/server design, the performance data analysis and the available CMSSW benchmark scores. The experience in the use of HEP code for benchmarking will be discussed and CMSSW benchmark results presented.

  1. Short-term effect of chewing gums containing probiotic Lactobacillus reuteri on the levels of inflammatory mediators in gingival crevicular fluid

    DEFF Research Database (Denmark)

    Twetman, Svante; Derawi, Bilal; Keller, Mette

    2009-01-01

    OBJECTIVE: To investigate the effect of a chewing gum containing probiotic bacteria on gingival inflammation and the levels of selected inflammatory mediators in gingival crevicular fluid (GCF). MATERIAL AND METHODS: Forty-two healthy adults with moderate levels of gingival inflammation entered...... a double-blind placebo-controlled study design. The subjects were randomly assigned to one of three parallel arms: Group A/P was given one active and one placebo gum daily, Group A/A received two active chewing gums, and Group P/P two placebo gums. The chewing gums contained two strains of Lactobacillus...... reuteri: ATCC 55730 and ATCC PTA 5289 (1 x 10(8) CFU/gum, respectively). The subjects were instructed to chew the gums for 10 min over the course of 2 weeks. Bleeding on probing (BOP) and GCF sampling were conducted at baseline and after 1, 2 and 4 weeks. The levels of IL-1beta, TNF-alpha, IL-6, IL-8...

  2. Adherence to Technology-Mediated Insomnia Treatment: A Meta-Analysis, Interviews, and Focus Groups.

    Science.gov (United States)

    Horsch, Corine; Lancee, Jaap; Beun, Robbert Jan; Neerincx, Mark A; Brinkman, Willem-Paul

    2015-09-04

    Several technologies have been proposed to support the reduction of insomnia complaints. A user-centered assessment of these technologies could provide insight into underlying factors related to treatment adherence. Gaining insight into adherence to technology-mediated insomnia treatment as a solid base for improving those adherence rates by applying adherence-enhancing strategies. Adherence to technology-mediated sleep products was studied in three ways. First, a meta-analysis was performed to investigate adherence rates in technology-mediated insomnia therapy. Several databases were queried for technology-mediated insomnia treatments. After inclusion and exclusion steps, data from 18 studies were retrieved and aggregated to find an average adherence rate. Next, 15 semistructured interviews about sleep-support technologies were conducted to investigate perceived adherence. Lastly, several scenarios were written about the usage of a virtual sleep coach that could support adherence rates. The scenarios were discussed in six different focus groups consisting of potential users (n=15), sleep experts (n=7), and coaches (n=9). From the meta-analysis, average treatment adherence appeared to be approximately 52% (95% CI 43%-61%) for technology-mediated insomnia treatments. This means that, on average, half of the treatment exercises were not executed, suggesting there is a substantial need for adherence and room for improvement in this area. However, the users in the interviews believed they adhered quite well to their sleep products. Users mentioned relying on personal commitment (ie, willpower) for therapy adherence. Participants of the focus groups reconfirmed their belief in the effectiveness of personal commitment, which they regarded as more effective than adherence-enhancing strategies. Although adherence rates for insomnia interventions indicate extensive room for improvement, users might not consider adherence to be a problem; they believe willpower to be an

  3. A Method for and Issues Associated with the Determination of Space Suit Joint Requirements

    Science.gov (United States)

    Matty, Jennifer E.; Aitchison, Lindsay

    2009-01-01

    In the design of a new space suit it is necessary to have requirements that define what mobility space suit joints should be capable of achieving in both a system and at the component level. NASA elected to divide mobility into its constituent parts-range of motion (ROM) and torque- in an effort to develop clean design requirements that limit subject performance bias and are easily verified. Unfortunately, the measurement of mobility can be difficult to obtain. Current technologies, such as the Vicon motion capture system, allow for the relatively easy benchmarking of range of motion (ROM) for a wide array of space suit systems. The ROM evaluations require subjects in the suit to accurately evaluate the ranges humans can achieve in the suit. However, when it comes to torque, there are significant challenges for both benchmarking current performance and writing requirements for future suits. This is reflected in the fact that torque definitions have been applied to very few types of space suits and with limited success in defining all the joints accurately. This paper discussed the advantages and disadvantages to historical joint torque evaluation methods, describes more recent efforts directed at benchmarking joint torques of prototype space suits, and provides an outline for how NASA intends to address joint torque in design requirements for the Constellation Space Suit System (CSSS).

  4. Mediation of parental educational level on fruit and vegetable intake among schoolchildren in ten European countries.

    Science.gov (United States)

    Lehto, Elviira; Ray, Carola; Te Velde, Saskia; Petrova, Stefka; Duleva, Vesselka; Krawinkel, Michael; Behrendt, Isabel; Papadaki, Angeliki; Kristjansdottir, Asa; Thorsdottir, Inga; Yngve, Agneta; Lien, Nanna; Lynch, Christel; Ehrenblad, Bettina; Vaz de Almeida, Maria Daniel; Ribic, Cirila Hlastan; Simčic, Irena; Roos, Eva

    2015-01-01

    To examine which factors act as mediators between parental educational level and children's fruit and vegetable (F&V) intake in ten European countries. Cross-sectional data were collected in ten European countries participating in the PRO GREENS project (2009). Schoolchildren completed a validated FFQ about their daily F&V intake and filled in a questionnaire about availability of F&V at home, parental facilitation of F&V intake, knowledge of recommendations about F&V intake, self-efficacy to eat F&V and liking for F&V. Parental educational level was determined from a questionnaire given to parents. The associations were examined with multilevel mediation analyses. Schools in Bulgaria, Finland, Germany, Greece, Iceland, the Netherlands, Norway, Portugal, Slovenia and Sweden. Eleven-year-old children (n 8159, response rate 72%) and their parents. In five of the ten countries, children with higher educated parents were more likely to report eating fruits daily. This association was mainly mediated by knowledge but self-efficacy, liking, availability and facilitation also acted as mediators in some countries. Parents' education was positively associated with their children's daily vegetable intake in seven countries, with knowledge and availability being the strongest mediators and self-efficacy and liking acting as mediators to some degree. Parental educational level correlated positively with children's daily F&V intake in most countries and the pattern of mediation varied among the participating countries. Future intervention studies that endeavour to decrease the educational-level differences in F&V intake should take into account country-specific features in the relevant determinants of F&V intake.

  5. Overview of the InterGroup protocols

    Energy Technology Data Exchange (ETDEWEB)

    Berket, Karlo [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Agarwal, Deborah A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Melliar-Smith, P. Michael [Univ. of California, Santa Barbara, CA (United States); Moser, Louise E. [Univ. of California, Santa Barbara, CA (United States)

    2001-03-01

    Existing reliable ordered group communication protocols have been developed for local-area networks and do not, in general, scale well to large numbers of nodes and wide-area networks. The InterGroup suite of protocols is a scalable group communication system that introduces a novel approach to handling group membership, and supports a receiver-oriented selection of service. The protocols are intended for a wide-area network, with a large number of nodes, that has highly variable delays and a high message loss rate, such as the Internet. The levels of the message delivery service range from unreliable unordered to reliable group timestamp ordered.

  6. The W (Sn-Mo)-specialized catinga suite and other granitoids of the Brusque Group, neo proterozoic of the state of Santa Catarina, Southern Brazil

    International Nuclear Information System (INIS)

    Castro, Neivaldo Araujo de; Crosta, Alvaro Penteado; Basei, Miguel Angelo Stipp

    1999-01-01

    The petrographic, geochemical and isotopic data on the granitoids intrusive in the Brusque Group, State of Santa Catarina, southern Brazil, are presented in this paper. These are late-to post-tectonic rocks, being the most evolved ones those that constitute the Catinga Suite. The granitoids intrusive in the southern domain of the Brusque Group are grayish rocks, in which biotite (when present) is practically the only mafic mineral. They are rather reduced, slightly alkalic, transitional between meta-and peraluminous. An acid subvolcanic pluton, the Ribeirao da Velha pluton, has similar petrographic and geochemical characteristics, and seems to be genetically related to these granitoids. LREE fractionation relative to HREE is incipient for the Catinga suite, and the REE patterns showing strong negative Eu anomaly. Initial 87 Sr/ 86 Sr ratios, from the literature for these granitoids are around 0.721 (Sao Joao Batista granitoid) and the only available t DM model age (Valsungana granitoid) points to a genesis from a continental crust of ca. 2020 Ma old. Gneiss-migmatitic rocks such as those that occur in the eastern portion of Brusque Group domain and as enclaves in the Nova Italia granitoid are strong candidates for protoliths of these granitoids. Little available information on the granitoids intrusive in the northern domain of the Brusque Group reports the presence of pink K-feldspar hornblende granitoids (Faxinal pluton) and light pink K-feldspar biotite granitoid (Guabiruba pluton). These granitoids are more enriched in K and more oxidized than those in the southern domain, and the LREE fractionation relative to HREE is strong, with the REE patterns showing incipient negative Eu anomaly. It is suggested that part of the Au concentrations found in the northern domain may be genetically associated with the granitoids, since they present characteristics favorable to promote Au mineralizations than the granitoids in the southern domain. Distinct protoliths and

  7. Enabling interoperability in Geoscience with GI-suite

    Science.gov (United States)

    Boldrini, Enrico; Papeschi, Fabrizio; Santoro, Mattia; Nativi, Stefano

    2015-04-01

    GI-suite is a brokering framework targeting interoperability of heterogeneous systems in the Geoscience domain. The framework is composed by different brokers each one focusing on a specific functionality: discovery, access and semantics (i.e. GI-cat, GI-axe, GI-sem). The brokering takes place between a set of heterogeneous publishing services and a set of heterogeneous consumer applications: the brokering target is represented by resources (e.g. coverages, features, or metadata information) required to seamlessly flow from the providers to the consumers. Different international and community standards are now supported by GI-suite, making possible the successful deployment of GI-suite in many international projects and initiatives (such as GEOSS, NSF BCube and several EU funded projects). As for the publisher side more than 40 standards and implementations are supported (e.g. Dublin Core, OAI-PMH, OGC W*S, Geonetwork, THREDDS Data Server, Hyrax Server, etc.). The support for each individual standard is provided by means of specific GI-suite components, called accessors. As for the consumer applications side more than 15 standards and implementations are supported (e.g. ESRI ArcGIS, Openlayers, OGC W*S, OAI-PMH clients, etc.). The support for each individual standard is provided by means of specific profiler components. The GI-suite can be used in different scenarios by different actors: - A data provider having a pre-existent data repository can deploy and configure GI-suite to broker it and making thus available its data resources through different protocols to many different users (e.g. for data discovery and/or data access) - A data consumer can use GI-suite to discover and/or access resources from a variety of publishing services that are already publishing data according to well-known standards. - A community can deploy and configure GI-suite to build a community (or project-specific) broker: GI-suite can broker a set of community related repositories and

  8. Do dimensions of ethnic identity mediate the association between perceived ethnic group discrimination and depressive symptoms?

    Science.gov (United States)

    Brittian, Aerika S; Kim, Su Yeong; Armenta, Brian E; Lee, Richard M; Umaña-Taylor, Adriana J; Schwartz, Seth J; Villalta, Ian K; Zamboanga, Byron L; Weisskirch, Robert S; Juang, Linda P; Castillo, Linda G; Hudson, Monika L

    2015-01-01

    Ethnic group discrimination represents a notable risk factor that may contribute to mental health problems among ethnic minority college students. However, cultural resources (e.g., ethnic identity) may promote psychological adjustment in the context of group-based discriminatory experiences. In the current study, we examined the associations between perceptions of ethnic group discrimination and depressive symptoms, and explored dimensions of ethnic identity (i.e., exploration, resolution, and affirmation) as mediators of this process among 2,315 ethnic minority college students (age 18 to 30 years; 37% Black, 63% Latino). Results indicated that perceived ethnic group discrimination was associated positively with depressive symptoms among students from both ethnic groups. The relationship between perceived ethnic group discrimination and depressive symptoms was mediated by ethnic identity affirmation for Latino students, but not for Black students. Ethnic identity resolution was negatively and indirectly associated with depressive symptoms through ethnic identity affirmation for both Black and Latino students. Implications for promoting ethnic minority college students' mental health and directions for future research are discussed. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  9. Gravitino Dark Matter in Tree Level Gauge Mediation with and without R-parity

    DEFF Research Database (Denmark)

    Arcadi, G.; Di Luzio, L.; Nardecchia, M.

    2011-01-01

    We investigate the cosmological aspects of Tree Level Gauge Mediation, a recently proposed mechanism in which the breaking of supersymmetry is communicated to the soft scalar masses by extra gauge interactions at the tree level. Embedding the mechanism in a Grand Unified Theory and requiring...... the observability of sfermion masses at the Large Hadron Collider, it follows that the Lightest Supersymmetric Particle is a gravitino with a mass of the order of 10 GeV. The analysis in the presence of R-parity shows that a typical Tree Level Gauge Mediation spectrum leads to an overabundance of the Dark Matter...... operators. We finally analyze the cosmological implications of this setup by identifying the phenomenologically viable regions of the parameter space....

  10. Collective Efficacy and Its Relationship with Leadership in a Computer-Mediated Project-Based Group Work

    Science.gov (United States)

    Huh, Yeol; Reigeluth, Charles M.; Lee, Dabae

    2014-01-01

    Based on Bandura's work, the four sources of efficacy shaping were examined in regard to frequency and students' perception of importance in a computer-mediated, project-based high school classroom. In a context of group work where there was no designated leader, groups' collective efficacy was examined if it has any relationship with individual's…

  11. Student Groups as Learning Entities: The Effect of Group Diversity and Teamwork Quality on Groups' Cognitive Complexity

    Science.gov (United States)

    Curseu, Petru L.; Pluut, Helen

    2013-01-01

    Collaborative learning has important group-level benefits, yet most studies in higher education only focus on individual benefits of collaborative learning experiences. This study extends these insights by testing a model in which teamwork quality mediates the impact of several compositional differences (gender, nationality and teamwork expertise…

  12. Tailoring Vantage 5 (fuel) to suit each operator's need

    Energy Technology Data Exchange (ETDEWEB)

    Chapin, D L; Secker, J R [Westinghouse Electric Corp., Philadelphia, PA (USA)

    1990-03-01

    By the end of 1989, Westinghouse Vantage 5 fuel had been reloaded into 36 nuclear power plants. The fuel offers a number of features operators can choose from to suit their own particular needs. Experience so far has shown the fuel to have performed well, with coolant activity levels remaining low. (author).

  13. Eudialyte-group minerals from the Monte de Trigo alkaline suite, Brazil: composition and petrological implications

    Directory of Open Access Journals (Sweden)

    Gaston Eduardo Enrich Rojas

    Full Text Available ABSTRACT: The Monte de Trigo alkaline suite is a SiO2-undersaturated syenite-gabbroid association from the Serra do Mar alkaline province. Eudialyte-group minerals (EGMs occur in one nepheline microsyenite dyke, associated with aegirine-augite, wöhlerite, låvenite, magnetite, zircon, titanite, britholite, and pyrochlore. Major compositional variations include Si (25.09- 25.57 apfu , Nb (0.31- 0.76 apfu , Fe (1.40-2.13 apfu , and Mn (1.36- 2.08 apfu . The EGMs also contain relatively high contents of Ca (6.13- 7.10 apfu , moderate enrichment of rare earth elements (0.38-0.67 apfu , and a relatively low Na content (11.02-12.28 apfu , which can be correlated with their transitional agpaitic assemblage. EGM compositions indicate a complex solid solution that includes eudialyte, kentbrooksite, feklichevite, zirsilite-(Ce, georgbarsanovite, and manganoeudialyte components. EGM trace element analyses show low Sr and Ba contents and a negative Eu/Eu* anomaly, which are interpreted as characteristic of the parental magma due to the previous fractionation of plagioclase and/or alkali feldspar. The EGMs from the dyke border have higher contents of Fe, Sr (2,161-2,699 ppm, Mg (1,179-3,582 ppm, and Zn (732- 852 ppm than those at the dyke center. These differences are related to the incorporation of xenoliths and xenocrysts of melatheralitic host rock into the nepheline-syenitic magma followed by crystal-melt diffusive exchange.

  14. PTSD Symptoms Mediate the Effect of Attachment on Pain and Somatisation after Whiplash Injury.

    Science.gov (United States)

    Andersen, Tonny Elmose; Elklit, Ask; Brink, Ole

    2013-01-01

    The development of persistent pain post-whiplash injury is still an unresolved mystery despite the fact that approximately 50% of individuals reporting whiplash develop persistent pain. There is agreement that high initial pain and PTSD symptoms are indicators of a poor prognosis after whiplash injury. Recently attachment insecurity has been proposed as a vulnerability factor for both pain and PTSD. In order to guide treatment it is important to examine possible mechanisms which may cause persistent pain and medically unexplained symptoms after a whiplash injury. The present study examines attachment insecurity and PTSD symptoms as possible vulnerability factors in relation to high levels of pain and somatisation after sub-acute whiplash injury. Data were collected from 327 patients (women = 204) referred consecutively to the emergency unit after acute whiplash injury. Within 1-month post injury, patients answered a questionnaire regarding attachment insecurity, pain, somatisation, and PTSD symptoms. Multiple mediation analyses were performed to assess whether the PTSD symptom clusters mediated the association between attachment insecurity, pain, and somatisation. A total of 15% fulfilled the DSM-IV symptom cluster criteria for a possible PTSD diagnosis and 11.6% fulfilled the criteria for somatisation. PTSD increased the likelihood of belonging to the moderate-severe pain group three-fold. In relation to somatisation the likelihood of belonging to the group was almost increased four-fold. The PTSD symptom clusters of avoidance and hyperarousal mediated the association between the attachment dimensions, pain, and somatisation. Acknowledging that PTSD is part of the aetiology involved in explaining persistent symptoms after whiplash, may help sufferers to gain early and more suited treatment, which in turn may prevent the condition from becoming chronic.

  15. A classical regression framework for mediation analysis: fitting one model to estimate mediation effects.

    Science.gov (United States)

    Saunders, Christina T; Blume, Jeffrey D

    2017-10-26

    Mediation analysis explores the degree to which an exposure's effect on an outcome is diverted through a mediating variable. We describe a classical regression framework for conducting mediation analyses in which estimates of causal mediation effects and their variance are obtained from the fit of a single regression model. The vector of changes in exposure pathway coefficients, which we named the essential mediation components (EMCs), is used to estimate standard causal mediation effects. Because these effects are often simple functions of the EMCs, an analytical expression for their model-based variance follows directly. Given this formula, it is instructive to revisit the performance of routinely used variance approximations (e.g., delta method and resampling methods). Requiring the fit of only one model reduces the computation time required for complex mediation analyses and permits the use of a rich suite of regression tools that are not easily implemented on a system of three equations, as would be required in the Baron-Kenny framework. Using data from the BRAIN-ICU study, we provide examples to illustrate the advantages of this framework and compare it with the existing approaches. © The Author 2017. Published by Oxford University Press.

  16. ASDA - Advanced Suit Design Analyzer computer program

    Science.gov (United States)

    Bue, Grant C.; Conger, Bruce C.; Iovine, John V.; Chang, Chi-Min

    1992-01-01

    An ASDA model developed to evaluate the heat and mass transfer characteristics of advanced pressurized suit design concepts for low pressure or vacuum planetary applications is presented. The model is based on a generalized 3-layer suit that uses the Systems Integrated Numerical Differencing Analyzer '85 in conjunction with a 41-node FORTRAN routine. The latter simulates the transient heat transfer and respiratory processes of a human body in a suited environment. The user options for the suit encompass a liquid cooled garment, a removable jacket, a CO2/H2O permeable layer, and a phase change layer.

  17. Reduced ferritin levels in individuals with non-O blood group

    DEFF Research Database (Denmark)

    Rigas, Andreas S; Berkfors, Adam A; Pedersen, Ole B

    2017-01-01

    stores expressed as ferritin levels. STUDY DESIGN AND METHODS: Ferritin levels were measured at least once for 30,595 Danish Blood Donor Study participants. Linear regression analyses were performed with the ABO blood group as explanatory variable and adjusted for age, number of donations 3 years before......BACKGROUND: Genomewide association studies have reported alleles in the ABO locus to be associated with ferritin levels. These studies warrant the investigation of a possible association between the ABO blood group and ferritin levels. We aimed to explore if ABO blood group is associated with iron...... blood group was associated with a ferritin level of less than 15 ng/mL. RESULTS: Non-O blood group donors had lower ferritin levels than blood group O donors, regardless of sex. Accordingly, risk of ferritin level of less than 15 ng/mL was increased for individuals with non-O blood group compared with O...

  18. Radical-Mediated Enzymatic Polymerizations

    Science.gov (United States)

    Zavada, Scott R.; Battsengel, Tsatsral; Scott, Timothy F.

    2016-01-01

    Polymerization reactions are commonly effected by exposing monomer formulations to some initiation stimulus such as elevated temperature, light, or a chemical reactant. Increasingly, these polymerization reactions are mediated by enzymes―catalytic proteins―owing to their reaction efficiency under mild conditions as well as their environmental friendliness. The utilization of enzymes, particularly oxidases and peroxidases, for generating radicals via reduction-oxidation mechanisms is especially common for initiating radical-mediated polymerization reactions, including vinyl chain-growth polymerization, atom transfer radical polymerization, thiol–ene step-growth polymerization, and polymerization via oxidative coupling. While enzyme-mediated polymerization is useful for the production of materials intended for subsequent use, it is especially well-suited for in situ polymerizations, where the polymer is formed in the place where it will be utilized. Such polymerizations are especially useful for biomedical adhesives and for sensing applications. PMID:26848652

  19. Use MACES IVA Suit for EVA Mobility Evaluations

    Science.gov (United States)

    Watson, Richard D.

    2014-01-01

    The use of an Intra-Vehicular Activity (IVA) suit for a spacewalk or Extra-Vehicular Activity (EVA) was evaluated for mobility and usability in the Neutral Buoyancy Lab (NBL) environment. The Space Shuttle Advanced Crew Escape Suit (ACES) has been modified (MACES) to integrate with the Orion spacecraft. The first several missions of the Orion MPCV spacecraft will not have mass available to carry an EVA specific suit so any EVA required will have to be performed by the MACES. Since the MACES was not designed with EVA in mind, it was unknown what mobility the suit would be able to provide for an EVA or if a person could perform useful tasks for an extended time inside the pressurized suit. The suit was evaluated in multiple NBL runs by a variety of subjects including crewmembers with significant EVA experience. Various functional mobility tasks performed included: translation, body positioning, carrying tools, body stabilization, equipment handling, and use of tools. Hardware configurations included with and without TMG, suit with IVA gloves and suit with EVA gloves. Most tasks were completed on ISS mockups with existing EVA tools. Some limited tasks were completed with prototype tools on a simulated rocky surface. Major findings include: demonstration of the ability to weigh-out the suit, understanding the need to have subjects perform multiple runs prior to getting feedback, determination of critical sizing factors, and need for adjustment of suit work envelop. The early testing has demonstrated the feasibility of EVA's limited duration and limited scope. Further testing is required with more flight like tasking and constraints to validate these early results. If the suit is used for EVA, it will require mission specific modifications for umbilical management or PLSS integration, safety tether attachment, and tool interfaces. These evaluations are continuing through calendar year 2014.

  20. Morphing: A Novel Approach to Astronaut Suit Sizing

    Science.gov (United States)

    Margerum, Sarah; Clowers, Kurt; Rajulu, Sudhakar

    2006-01-01

    The fitting of a spacesuit to an astronaut is an iterative process consisting of two parts. The first uses anthropometric data to provide an approximation of the suit components that will fit the astronaut. The second part is the subjective fitting, where small adjustments are made based on the astronaut s preference. By providing a better approximation of the correct suit components, the entire fit process time can be reduced significantly. The goals of this project are twofold: (1) To evaluate the effectiveness of the existing sizing algorithm for the Mark III Hybrid suit and (2) to determine what additional components are needed in order to provide adequate sizing for the existing astronaut population. A single subject was scanned using a 3D whole-body scanner (VITUS 3D) in the Mark III suit in eight different poses and four subjects in minimal clothing were also scanned in similar poses. The 3D external body scans of the suit and the subject are overlaid and visually aligned in a customized MATLAB program. The suit components were contracted or expanded linearly along the subjects limbs to match the subjects segmental lengths. Two independent measures were obtained from the morphing program on four subjects and compared with the existing sizing information. Two of the four subjects were in correspondence with the sizing algorithm and morphing results. The morphing outcome for a third subject, incompatible with the suit, suggested that an additional arm element at least 6 inches smaller than the existing smallest suit component would need to be acquired. The morphing result of the fourth subject, deemed incompatible with the suit using the sizing algorithm, indicated a different suit configuration which would be compatible. This configuration matched with the existing suit fit check data.

  1. Parental mediation and cyberbullying - a longitudinal study.

    Science.gov (United States)

    Chng, Grace S; Liau, Albert; Khoo, Angeline; Li, Dongdong

    2014-01-01

    Parents use active and restrictive mediation strategies to guide and regulate children's online participation and the online risks they encounter. However, changes in parental mediation do occur over time and the effectiveness of these strategies on cyberbullying demands for further empirical investigation. The current study addresses these issues with a sample of 1084 students (49% girls) in a longitudinal, three-wave design. Gender differences were tested via multi-group analyses. Longitudinal growth models showed that parental use of both active and restrictive mediation decreased over time. For both types of mediation, the mean rate of change had a significant effect on boys' engagement in cyberbullying, but not for girls. Initial levels of restrictive mediation, but not active mediation, were found to be significantly predictive of cyberbullying in both genders. Girls had higher initial levels of both parental mediation types in comparison to boys. The results reveal that the effectiveness of active and restrictive mediation in relation to students' cyberbullying differs and informs us on gender differences. The implications of these results for parental education in online mediation are discussed.

  2. What carries a mediation process? Configural analysis of mediation.

    Science.gov (United States)

    von Eye, Alexander; Mun, Eun Young; Mair, Patrick

    2009-09-01

    Mediation is a process that links a predictor and a criterion via a mediator variable. Mediation can be full or partial. This well-established definition operates at the level of variables even if they are categorical. In this article, two new approaches to the analysis of mediation are proposed. Both of these approaches focus on the analysis of categorical variables. The first involves mediation analysis at the level of configurations instead of variables. Thus, mediation can be incorporated into the arsenal of methods of analysis for person-oriented research. Second, it is proposed that Configural Frequency Analysis (CFA) can be used for both exploration and confirmation of mediation relationships among categorical variables. The implications of using CFA are first that mediation hypotheses can be tested at the level of individual configurations instead of variables. Second, this approach leaves the door open for different types of mediation processes to exist within the same set. Using a data example, it is illustrated that aggregate-level analysis can overlook mediation processes that operate at the level of individual configurations.

  3. Comparison of the Effect of Noise Levels on Stress Response in Two Different Operation Groups in an Orthopedic Surgery Room

    Directory of Open Access Journals (Sweden)

    Hasibe Baytan Yildiz

    2016-09-01

    Full Text Available Aim: The aim of this randomized, single-blinded study was to evaluate the effects of noise on hemodynamic and neuroendocrine stress response by measuring the level of noise in the surgery rooms of patients undergoing knee operations under neuroaxial anesthesia. Gerec ve Yontem: We compared patient responses from two groups of patients: those undergoing knee operations in a surgery room where the noise level (measured in decibels is high, and those undergoing meniscus operations in a surgery room with lower noise levels. The STAI, the State-Trait Anxiety Inventory (STAI-1, and the anxiety test (STAI-2wereperformed at preoperative and postoperative periods. 20 ml of blood sample was taken for basal, intraoperative 30th minute, and postoperative 1st hour measurements. Systolic, diastolic, and mean arterial blood pressures were found to be higher in the high noise level group. ACTH levels were increased during the early postoperative period and became normal during the late postoperative period in the high noise level group whereas ACTH levels were significantly decreased in the low-noise level group. Basal cortisol levels were significantly higher in the high noise level group. HCRP, an inflammatory response mediator was found to be decreased in both groups. Early and late blood glucose levels were significantly higher in the high noise group. There was a greater increase in early and late blood glucose levels in the high noise group. In the postoperative period, although the state-trait anxiety inventory (STAI-2 levels being higher in patients subject to noisier environment determines how people feel independent of the conditions and state they are in, this result made us consider that the noise the patients were subjected to in the intraoperative period may cause a stress response. Discussion: As a result we believe that standard noise levels should be achieved by reducing the factors causing high noise levels in the operating room. This will

  4. Accounting for sex differences in PTSD: A multi-variable mediation model.

    Science.gov (United States)

    Christiansen, Dorte M; Hansen, Maj

    2015-01-01

    Approximately twice as many females as males are diagnosed with posttraumatic stress disorder (PTSD). However, little is known about why females report more PTSD symptoms than males. Prior studies have generally focused on few potential mediators at a time and have often used methods that were not ideally suited to test for mediation effects. Prior research has identified a number of individual risk factors that may contribute to sex differences in PTSD severity, although these cannot fully account for the increased symptom levels in females when examined individually. The present study is the first to systematically test the hypothesis that a combination of pre-, peri-, and posttraumatic risk factors more prevalent in females can account for sex differences in PTSD severity. The study was a quasi-prospective questionnaire survey assessing PTSD and related variables in 73.3% of all Danish bank employees exposed to bank robbery during the period from April 2010 to April 2011. Participants filled out questionnaires 1 week (T1, N=450) and 6 months after the robbery (T2, N=368; 61.1% females). Mediation was examined using an analysis designed specifically to test a multiple mediator model. Females reported more PTSD symptoms than males and higher levels of neuroticism, depression, physical anxiety sensitivity, peritraumatic fear, horror, and helplessness (the A2 criterion), tonic immobility, panic, dissociation, negative posttraumatic cognitions about self and the world, and feeling let down. These variables were included in the model as potential mediators. The combination of risk factors significantly mediated the association between sex and PTSD severity, accounting for 83% of the association. The findings suggest that females report more PTSD symptoms because they experience higher levels of associated risk factors. The results are relevant to other trauma populations and to other trauma-related psychiatric disorders more prevalent in females, such as depression

  5. Suited Contingency Ops Food - 2

    Science.gov (United States)

    Glass, J. W.; Leong, M. L.; Douglas, G. L.

    2014-01-01

    The contingency scenario for an emergency cabin depressurization event may require crewmembers to subsist in a pressurized suit for up to 144 hours. This scenario requires the capability for safe nutrition delivery through a helmet feed port against a 4 psi pressure differential to enable crewmembers to maintain strength and cognition to perform critical tasks. Two nutritional delivery prototypes were developed and analyzed for compatibility with the helmet feed port interface and for operational effectiveness against the pressure differential. The bag-in-bag (BiB) prototype, designed to equalize the suit pressure with the beverage pouch and enable a crewmember to drink normally, delivered water successfully to three different subjects in suits pressurized to 4 psi. The Boa restrainer pouch, designed to provide mechanical leverage to overcome the pressure differential, did not operate sufficiently. Guidelines were developed and compiled for contingency beverages that provide macro-nutritional requirements, a minimum one-year shelf life, and compatibility with the delivery hardware. Evaluation results and food product parameters have the potential to be used to improve future prototype designs and develop complete nutritional beverages for contingency events. These feeding capabilities would have additional use on extended surface mission EVAs, where the current in-suit drinking device may be insufficient.

  6. Interoperative efficiency in minimally invasive surgery suites.

    Science.gov (United States)

    van Det, M J; Meijerink, W J H J; Hoff, C; Pierie, J P E N

    2009-10-01

    Performing minimally invasive surgery (MIS) in a conventional operating room (OR) requires additional specialized equipment otherwise stored outside the OR. Before the procedure, the OR team must collect, prepare, and connect the equipment, then take it away afterward. These extra tasks pose a thread to OR efficiency and may lengthen turnover times. The dedicated MIS suite has permanently installed laparoscopic equipment that is operational on demand. This study presents two experiments that quantify the superior efficiency of the MIS suite in the interoperative period. Preoperative setup and postoperative breakdown times in the conventional OR and the MIS suite in an experimental setting and in daily practice were analyzed. In the experimental setting, randomly chosen OR teams simulated the setup and breakdown for a standard laparoscopic cholecystectomy (LC) and a complex laparoscopic sigmoid resection (LS). In the clinical setting, the interoperative period for 66 LCs randomly assigned to the conventional OR or the MIS suite were analyzed. In the experimental setting, the setup and breakdown times were significantly shorter in the MIS suite. The difference between the two types of OR increased for the complex procedure: 2:41 min for the LC (p < 0.001) and 10:47 min for the LS (p < 0.001). In the clinical setting, the setup and breakdown times as a whole were not reduced in the MIS suite. Laparoscopic setup and breakdown times were significantly shorter in the MIS suite (mean difference, 5:39 min; p < 0.001). Efficiency during the interoperative period is significantly improved in the MIS suite. The OR nurses' tasks are relieved, which may reduce mental and physical workload and improve job satisfaction and patient safety. Due to simultaneous tasks of other disciplines, an overall turnover time reduction could not be achieved.

  7. Suite of Activity-Based Probes for Cellulose-Degrading Enzymes

    Energy Technology Data Exchange (ETDEWEB)

    Chauvigne-Hines, Lacie M.; Anderson, Lindsey N.; Weaver, Holly M.; Brown, Joseph N.; Koech, Phillip K.; Nicora, Carrie D.; Hofstad, Beth A.; Smith, Richard D.; Wilkins, Michael J.; Callister, Stephen J.; Wright, Aaron T.

    2012-12-19

    Microbial glycoside hydrolases play a dominant role in the biochemical conversion of cellulosic biomass to high-value biofuels. Anaerobic cellulolytic bacteria are capable of producing multicomplex catalytic subunits containing cell-adherent cellulases, hemicellulases, xylanases, and other glycoside hydrolases to facilitate the degradation of highly recalcitrant cellulose and other related plant cell wall polysaccharides. Clostridium thermocellum is a cellulosome producing bacterium that couples rapid reproduction rates to highly efficient degradation of crystalline cellulose. Herein, we have developed and applied a suite of difluoromethylphenyl aglycone, N-halogenated glycosylamine, and 2-deoxy-2-fluoroglycoside activity-based protein profiling (ABPP) probes to the direct labeling of the C. thermocellum cellulosomal secretome. These activity-based probes (ABPs) were synthesized with alkynes to harness the utility and multimodal possibilities of click chemistry, and to increase enzyme active site inclusion for LC-MS analysis. We directly analyzed ABP-labeled and unlabeled global MS data, revealing ABP selectivity for glycoside hydrolase (GH) enzymes in addition to a large collection of integral cellulosome-containing proteins. By identifying reactivity and selectivity profiles for each ABP, we demonstrate our ability to widely profile the functional cellulose degrading machinery of the bacterium. Derivatization of the ABPs, including reactive groups, acetylation of the glycoside binding groups, and mono- and disaccharide binding groups, resulted in considerable variability in protein labeling. Our probe suite is applicable to aerobic and anaerobic cellulose degrading systems, and facilitates a greater understanding of the organismal role associated within biofuel development.

  8. The Variable Vector Countermeasure Suit (V2Suit for Space Habitation and Exploration

    Directory of Open Access Journals (Sweden)

    Kevin R Duda

    2015-04-01

    Full Text Available The Variable Vector Countermeasure Suit (V2Suit for Space Habitation and Exploration is a novel system concept that provides a platform for integrating sensors and actuators with daily astronaut intravehicular activities to improve health and performance, while reducing the mass and volume of the physiologic adaptation countermeasure systems, as well as the required exercise time during long-duration space exploration missions. The V2Suit system leverages wearable kinematic monitoring technology and uses inertial measurement units (IMUs and control moment gyroscopes (CMGs within miniaturized modules placed on body segments to provide a viscous resistance during movements against a specified direction of down – initially as a countermeasure to the sensorimotor adaptation performance decrements that manifest themselves while living and working in microgravity and during gravitational transitions during long-duration spaceflight, including post-flight recovery and rehabilitation. Several aspects of the V2Suit system concept were explored and simulated prior to developing a brassboard prototype for technology demonstration. This included a system architecture for identifying the key components and their interconnects, initial identification of key human-system integration challenges, development of a simulation architecture for CMG selection and parameter sizing, and the detailed mechanical design and fabrication of a module. The brassboard prototype demonstrates closed-loop control from down initialization through CMG actuation, and provides a research platform for human performance evaluations to mitigate sensorimotor adaptation, as well as a tool for determining the performance requirements when used as a musculoskeletal deconditioning countermeasure. This type of countermeasure system also has Earth benefits, particularly in gait or movement stabilization and rehabilitation.

  9. Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity

    DEFF Research Database (Denmark)

    Dantoft, Thomas Meinertz; Skovbjerg, Sine; Andersson, Linus

    2015-01-01

    Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by reports of recurrent symptoms in response to low level exposure to various chemical substances. Recent findings suggests that dysregulation of the immune system may play a role in MCS pathophysiology. The aim of this study...... inflammatory mediator profiles (P>0.05) at baseline. Likewise, direct comparison of mediator levels in the MCS group and controls after n-butanol exposure revealed no significant group differences. We demonstrate no abnormal upper airway inflammatory mediator levels in MCS subjects before or after a symptom...

  10. The ZPIC educational code suite

    Science.gov (United States)

    Calado, R.; Pardal, M.; Ninhos, P.; Helm, A.; Mori, W. B.; Decyk, V. K.; Vieira, J.; Silva, L. O.; Fonseca, R. A.

    2017-10-01

    Particle-in-Cell (PIC) codes are used in almost all areas of plasma physics, such as fusion energy research, plasma accelerators, space physics, ion propulsion, and plasma processing, and many other areas. In this work, we present the ZPIC educational code suite, a new initiative to foster training in plasma physics using computer simulations. Leveraging on our expertise and experience from the development and use of the OSIRIS PIC code, we have developed a suite of 1D/2D fully relativistic electromagnetic PIC codes, as well as 1D electrostatic. These codes are self-contained and require only a standard laptop/desktop computer with a C compiler to be run. The output files are written in a new file format called ZDF that can be easily read using the supplied routines in a number of languages, such as Python, and IDL. The code suite also includes a number of example problems that can be used to illustrate several textbook and advanced plasma mechanisms, including instructions for parameter space exploration. We also invite contributions to this repository of test problems that will be made freely available to the community provided the input files comply with the format defined by the ZPIC team. The code suite is freely available and hosted on GitHub at https://github.com/zambzamb/zpic. Work partially supported by PICKSC.

  11. Adaptive and innate immune reactions regulating mast cell activation: from receptor-mediated signaling to responses

    DEFF Research Database (Denmark)

    Tkaczyk, Christine; Jensen, Bettina M; Iwaki, Shoko

    2006-01-01

    differentially activate multiple signaling pathways within the mast cells required for the generation and/or release of inflammatory mediators. Thus, the composition of the suite of mediators released and the physiologic ramifications of these responses are dependent on the stimuli and the microenvironment...

  12. Relationship between Individual and Organizational Learning: Mediating Role of Team Learning

    OpenAIRE

    Monika Stelmaszczyk

    2016-01-01

    The aim of this paper is to recognize the relationships between individual and organizational learning while considering team learning as a mediator of these relationships. The research object is a large Polish enterprise specializing in the production of cast-iron items. In order to test assumed research hypotheses, statistical analyses were conducted using the IBM SPSS Statistics Suite, version 20. The suite helped conduct correlation analyses concatenation, line regression analyses and med...

  13. [Antigravity suit used for neurosurgical operations in sitting position].

    Science.gov (United States)

    Szpiro-Zurkowska, A; Milczarek, Z; Marchel, A; Jagielski, J

    1996-01-01

    The aviator's antigravity suit (G-suit) was used for 40 operations on neurosurgical patients operated on in sitting position. The G-suit was filled with air to 0.2 atmosphere (20 kPa) pressure in 26 cases, and 0.3 atm. (30 kPa) in 14 cases. In all cases G-suit filling was followed by central venous pressure rise and mean arterial pressure rise. Venous air embolism was found in 5 (12.5%) patients. No other complications connected with the use of G-suit were observed.

  14. Bayesian Group Bridge for Bi-level Variable Selection.

    Science.gov (United States)

    Mallick, Himel; Yi, Nengjun

    2017-06-01

    A Bayesian bi-level variable selection method (BAGB: Bayesian Analysis of Group Bridge) is developed for regularized regression and classification. This new development is motivated by grouped data, where generic variables can be divided into multiple groups, with variables in the same group being mechanistically related or statistically correlated. As an alternative to frequentist group variable selection methods, BAGB incorporates structural information among predictors through a group-wise shrinkage prior. Posterior computation proceeds via an efficient MCMC algorithm. In addition to the usual ease-of-interpretation of hierarchical linear models, the Bayesian formulation produces valid standard errors, a feature that is notably absent in the frequentist framework. Empirical evidence of the attractiveness of the method is illustrated by extensive Monte Carlo simulations and real data analysis. Finally, several extensions of this new approach are presented, providing a unified framework for bi-level variable selection in general models with flexible penalties.

  15. Phenomenology of Minimal Unified Tree Level Gauge Mediation at the LHC

    CERN Document Server

    Monaco, Maurizio; Romanino, Andrea; Spinrath, Martin

    2013-01-01

    We study the collider phenomenology of the minimal unified version of the supersymmetry breaking scheme called Tree-level Gauge Mediation. We identify a peculiar source of gaugino mass non-universality related to the necessary SU(5)-breaking in the light fermion mass ratios and a gaugino mass sum rule at the GUT scale, 3 M_2 + 2 M_3 = 5 M_1, which represents a smoking gun of this scenario, together with the known tree-level sfermion mass ratio \\tilde m_{d^c,l} = \\sqrt{2} \\tilde m_{q,u^c,e^c}. The boundary conditions of the soft SUSY breaking terms can be parameterised in terms of six relevant parameters only (plus the sign of the \\mu-parameter). We analyze the parameter space and define three benchmark points, corresponding to the three possible NLSPs, a bino- or wino-like neutralino or the stau. The LSP is the gravitino as in gauge mediation. For these benchmark points we show possible signatures at the LHC focusing on the Razor variable. We also comment on the Higgs mass.

  16. Oracle SOA Suite 11g performance cookbook

    CERN Document Server

    Brasier, Matthew; Wright, Nicholas

    2013-01-01

    This is a Cookbook with interesting, hands-on recipes, giving detailed descriptions and lots of practical walkthroughs for boosting the performance of your Oracle SOA Suite.This book is for Oracle SOA Suite 11g administrators, developers, and architects who want to understand how they can maximise the performance of their SOA Suite infrastructure. The recipes contain easy to follow step-by-step instructions and include many helpful and practical tips. It is suitable for anyone with basic operating system and application server administration experience.

  17. Exploration Space Suit Architecture and Destination Environmental-Based Technology Development

    Science.gov (United States)

    Hill, Terry R.; McFarland, Shane M.; Korona, F. Adam

    2013-01-01

    This paper continues forward where EVA Space Suit Architecture: Low Earth Orbit Vs. Moon Vs. Mars left off in the development of a space suit architecture that is modular in design and could be reconfigured prior to launch or during any given mission depending on the tasks or destination. This space suit system architecture and technologies required based on human exploration (EVA) destinations will be discussed, and how these systems should evolve to meet the future exploration EVA needs of the US human space flight program. A series of exercises and analyses provided a strong indication that the Constellation Program space suit architecture, with its maximum reuse of technology and functionality across a range of mission profiles and destinations, is postured to provide a viable solution for future space exploration missions. The destination environmental analysis demonstrates that the modular architecture approach could provide the lowest mass and mission cost for the protection of the crew, given any human mission outside of low-Earth orbit. Additionally, some of the high-level trades presented here provide a review of the environmental and nonenvironmental design drivers that will become increasingly important as humans venture farther from Earth. The presentation of destination environmental data demonstrates a logical clustering of destination design environments that allows a focused approach to technology prioritization, development, and design that will maximize the return on investment, largely independent of any particular design reference mission.

  18. Safety in the use of pressurized suits

    International Nuclear Information System (INIS)

    1984-01-01

    This Code of Practice describes the procedures relating to the safe operation of Pressurized Suit Areas and their supporting services. It is directed at personnel responsible for the design and/or operation of Pressurized Suit Areas. (author)

  19. Asteroid Redirect Crewed Mission Space Suit and EVA System Architecture Trade Study

    Science.gov (United States)

    Blanco, Raul A.; Bowie, Jonathan T.; Watson, Richard D.; Sipila, Stephanie A.

    2014-01-01

    The Asteroid Redirect Crewed Mission (ARCM) requires a Launch/Entry/Abort (LEA) suit capability and short duration Extra Vehicular Activity (EVA) capability for Orion. The EVAs will involve a two-person crew for approximately four hours. Currently, two EVAs are planned with one contingency EVA in reserve. Providing this EVA capability is very challenging due to system level constraints and a new and unknown environment. The goal of the EVA architecture for ARCM is one that builds upon previously developed technologies and lessons learned, and that accomplishes the ARCM mission while providing a stepping stone to future missions and destinations. The primary system level constraints are to 1) minimize system mass and volume and 2) minimize the interfacing impacts to the baseline Orion design. In order to minimize the interfacing impacts and to not perturb the baseline Orion schedule, the concept of adding "kits" to the baseline system is proposed. These kits consist of: an EVA kit (converts LEA suit to EVA suit), EVA Servicing and Recharge Kit (provides suit consumables), the EVA Tools, Translation Aids & Sample Container Kit (the tools and mobility aids to complete the tasks), the EVA Communications Kit (interface between the EVA radio and the MPCV), and the Cabin Repress Kit (represses the MPCV between EVAs). This paper will focus on the trade space, analysis, and testing regarding the space suit (pressure garment and life support system). Historical approaches and lessons learned from all past EVA operations were researched. Previous and current, successfully operated EVA hardware and high technology readiness level (TRL) hardware were evaluated, and a trade study was conducted for all possible pressure garment and life support options. Testing and analysis was conducted and a recommended EVA system architecture was proposed. Pressure garment options that were considered for this mission include the currently in-use ISS EVA Mobility Unit (EMU), all variations of

  20. Norms as Group-Level Constructs: Investigating School-Level Teen Pregnancy Norms and Behaviors.

    Science.gov (United States)

    Mollborn, Stefanie; Domingue, Benjamin W; Boardman, Jason D

    2014-09-01

    Social norms are a group-level phenomenon, but past quantitative research has rarely measured them in the aggregate or considered their group-level properties. We used the school-based design of the National Longitudinal Study of Adolescent Health to measure normative climates regarding teen pregnancy across 75 U.S. high schools. We distinguished between the strength of a school's norm against teen pregnancy and the consensus around that norm. School-level norm strength and dissensus were strongly (r = -0.65) and moderately (r = 0.34) associated with pregnancy prevalence within schools, respectively. Normative climate partially accounted for observed racial differences in school pregnancy prevalence, but norms were a stronger predictor than racial composition. As hypothesized, schools with both a stronger average norm against teen pregnancy and greater consensus around the norm had the lowest pregnancy prevalence. Results highlight the importance of group-level normative processes and of considering the local school environment when designing policies to reduce teen pregnancy.

  1. Space Suit Joint Torque Measurement Method Validation

    Science.gov (United States)

    Valish, Dana; Eversley, Karina

    2012-01-01

    In 2009 and early 2010, a test method was developed and performed to quantify the torque required to manipulate joints in several existing operational and prototype space suits. This was done in an effort to develop joint torque requirements appropriate for a new Constellation Program space suit system. The same test method was levied on the Constellation space suit contractors to verify that their suit design met the requirements. However, because the original test was set up and conducted by a single test operator there was some question as to whether this method was repeatable enough to be considered a standard verification method for Constellation or other future development programs. In order to validate the method itself, a representative subset of the previous test was repeated, using the same information that would be available to space suit contractors, but set up and conducted by someone not familiar with the previous test. The resultant data was compared using graphical and statistical analysis; the results indicated a significant variance in values reported for a subset of the re-tested joints. Potential variables that could have affected the data were identified and a third round of testing was conducted in an attempt to eliminate and/or quantify the effects of these variables. The results of the third test effort will be used to determine whether or not the proposed joint torque methodology can be applied to future space suit development contracts.

  2. Sibelius. Karelia Suite, Op. 11 / Robert Layton

    Index Scriptorium Estoniae

    Layton, Robert

    1996-01-01

    Uuest heliplaadist "Sibelius. Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi" DG 447 760-2GH (72 minutes: DDD)

  3. Advanced EVA Suit Camera System Development Project

    Science.gov (United States)

    Mock, Kyla

    2016-01-01

    The National Aeronautics and Space Administration (NASA) at the Johnson Space Center (JSC) is developing a new extra-vehicular activity (EVA) suit known as the Advanced EVA Z2 Suit. All of the improvements to the EVA Suit provide the opportunity to update the technology of the video imagery. My summer internship project involved improving the video streaming capabilities of the cameras that will be used on the Z2 Suit for data acquisition. To accomplish this, I familiarized myself with the architecture of the camera that is currently being tested to be able to make improvements on the design. Because there is a lot of benefit to saving space, power, and weight on the EVA suit, my job was to use Altium Design to start designing a much smaller and simplified interface board for the camera's microprocessor and external components. This involved checking datasheets of various components and checking signal connections to ensure that this architecture could be used for both the Z2 suit and potentially other future projects. The Orion spacecraft is a specific project that may benefit from this condensed camera interface design. The camera's physical placement on the suit also needed to be determined and tested so that image resolution can be maximized. Many of the options of the camera placement may be tested along with other future suit testing. There are multiple teams that work on different parts of the suit, so the camera's placement could directly affect their research or design. For this reason, a big part of my project was initiating contact with other branches and setting up multiple meetings to learn more about the pros and cons of the potential camera placements we are analyzing. Collaboration with the multiple teams working on the Advanced EVA Z2 Suit is absolutely necessary and these comparisons will be used as further progress is made for the overall suit design. This prototype will not be finished in time for the scheduled Z2 Suit testing, so my time was

  4. The Zoot Suit Riots: Exploring Social Issues in American History

    Science.gov (United States)

    Chiodo, John J.

    2013-01-01

    The Zoot Suit Riots provide students with a case study of social unrest in American history. The influx of Latinos into the Los Angeles area prior to World War II created high levels of social unrest between Mexican Americans, military servicemen, and local residences. With large numbers of soldiers stationed in the area during the Second World…

  5. Advanced Sensor Platform to Evaluate Manloads For Exploration Suit Architectures

    Science.gov (United States)

    McFarland, Shane; Pierce, Gregory

    2016-01-01

    Space suit manloads are defined as the outer bounds of force that the human occupant of a suit is able to exert onto the suit during motion. They are defined on a suit-component basis as a unit of maximum force that the suit component in question must withstand without failure. Existing legacy manloads requirements are specific to the suit architecture of the EMU and were developed in an iterative fashion; however, future exploration needs dictate a new suit architecture with bearings, load paths, and entry capability not previously used in any flight suit. No capability currently exists to easily evaluate manloads imparted by a suited occupant, which would be required to develop requirements for a flight-rated design. However, sensor technology has now progressed to the point where an easily-deployable, repeatable and flexible manloads measuring technique could be developed leveraging recent advances in sensor technology. INNOVATION: This development positively impacts schedule, cost and safety risk associated with new suit exploration architectures. For a final flight design, a comprehensive and accurate man loads requirements set must be communicated to the contractor; failing that, a suit design which does not meet necessary manloads limits is prone to failure during testing or worse, during an EVA, which could cause catastrophic failure of the pressure garment posing risk to the crew. This work facilitates a viable means of developing manloads requirements using a range of human sizes & strengths. OUTCOME / RESULTS: Performed sensor market research. Highlighted three viable options (primary, secondary, and flexible packaging option). Designed/fabricated custom bracket to evaluate primary option on a single suit axial. Manned suited manload testing completed and general approach verified.

  6. Correction factors for assessing immersion suits under harsh conditions.

    Science.gov (United States)

    Power, Jonathan; Tikuisis, Peter; Ré, António Simões; Barwood, Martin; Tipton, Michael

    2016-03-01

    Many immersion suit standards require testing of thermal protective properties in calm, circulating water while these suits are typically used in harsher environments where they often underperform. Yet it can be expensive and logistically challenging to test immersion suits in realistic conditions. The goal of this work was to develop a set of correction factors that would allow suits to be tested in calm water yet ensure they will offer sufficient protection in harsher conditions. Two immersion studies, one dry and the other with 500 mL of water within the suit, were conducted in wind and waves to measure the change in suit insulation. In both studies, wind and waves resulted in a significantly lower immersed insulation value compared to calm water. The minimum required thermal insulation for maintaining heat balance can be calculated for a given mean skin temperature, metabolic heat production, and water temperature. Combining the physiological limits of sustainable cold water immersion and actual suit insulation, correction factors can be deduced for harsh conditions compared to calm. The minimum in-situ suit insulation to maintain thermal balance is 1.553-0.0624·TW + 0.00018·TW(2) for a dry calm condition. Multiplicative correction factors to the above equation are 1.37, 1.25, and 1.72 for wind + waves, 500 mL suit wetness, and both combined, respectively. Calm water certification tests of suit insulation should meet or exceed the minimum in-situ requirements to maintain thermal balance, and correction factors should be applied for a more realistic determination of minimum insulation for harsh conditions. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  7. Z-2 Prototype Space Suit Development

    Science.gov (United States)

    Ross, Amy; Rhodes, Richard; Graziosi, David; Jones, Bobby; Lee, Ryan; Haque, Bazle Z.; Gillespie, John W., Jr.

    2014-01-01

    NASA's Z-2 prototype space suit is the highest fidelity pressure garment from both hardware and systems design perspectives since the Space Shuttle Extravehicular Mobility Unit (EMU) was developed in the late 1970's. Upon completion the Z-2 will be tested in the 11 foot human-rated vacuum chamber and the Neutral Buoyancy Laboratory (NBL) at the NASA Johnson Space Center to assess the design and to determine applicability of the configuration to micro-, low- (asteroid), and planetary- (surface) gravity missions. This paper discusses the 'firsts' that the Z-2 represents. For example, the Z-2 sizes to the smallest suit scye bearing plane distance for at least the last 25 years and is being designed with the most intensive use of human models with the suit model.

  8. The mediating role of the home environment in relation to parental educational level and preschool children's screen time: a cross-sectional study.

    Science.gov (United States)

    Määttä, Suvi; Kaukonen, Riikka; Vepsäläinen, Henna; Lehto, Elviira; Ylönen, Anna; Ray, Carola; Erkkola, Maijaliisa; Roos, Eva

    2017-09-02

    Previous studies suggest that preschoolers from low socioeconomic backgrounds engage in more screen time. Still, the factors in the social and physical home environment driving these differences in preschool children's screen time are poorly understood. This study examines potential home environment mediators in the associations between parental educational level and preschoolers' screen time. A total of 864 children aged 3-6 years and their parents participated in a cross-sectional DAGIS study in 2015-2016. Parents recorded their children's screen time in a diary (N = 823). For the analyses, the daily average screen time at home was calculated. Parental questionnaires (N = 808) assessed educational level and eight social and physical environment factors in the home (i.e., descriptive norm for children's screen time, parental screen use in front of children, parental importance for limiting children's screen time, parental attitude toward societal pressures for children's screen time, access to screens at home, parental self-efficacy for limiting children's screen time, satisfaction of children's screen time, and rules for limiting children's screen time). Parental education was grouped into low, middle, and high education. The associations were tested by conducting mediation analyses adjusted by season and children's sex and age. The significant mediators in the single-mediator models were included in the final multiple-mediator models. Of the potential eight mediators, the following four had a significant indirect association: descriptive norm for children's screen time, parental screen use in front of children, parental importance for limiting children's screen time, and parental attitude toward societal pressures for children's screen time. Parents with high education had lower descriptive norm and used fewer screens in front of children compared to parents with middle or low education, and in turn, these factors were associated with less screen time among

  9. Effectiveness of group-mediated lifestyle physical activity (glpa) program for health benefit in physical activity among elderly people at rural thailand

    International Nuclear Information System (INIS)

    Ethisan, P.; Chapman, R.

    2015-01-01

    Elderly population is considered as a vulnerable group and prone to develop multiple medical problems. This aging population is rapidly increasing in developing countries especially in Thailand. Methods: This study was a quasi-experimental study to evaluate the effectiveness of Group-Mediated Lifestyle Physical Activity program on change health benefit in physical activity among elderly people by using validated and reliable Global Physical Activity Questionnaire-GPAQv2. The study was conducted in Phranakhonsiayutthaya district, Ayutthaya province due to its population being the second highest elderly in the Central Region of Thailand. A total of 102 persons of age 60 and over who could read and write Thai language were selected purposively. However, 52 elderly were enrolled in the intervention group and 50 were enrolled for the control group. General Linear Model repeated-measures ANOVA was used to evaluate the effects of Group-Mediated Lifestyle Physical Activity (GLPA) program on change health benefit in physical activity among elderly. Results: Overall health benefit at baseline were similar between intervention and control group and found statistically non-significant with p-value 0.638 (>0.05). However, the mean score of health benefit was 23.21 ± 29.23 in intervention group and 20.74 ± 23.18 in control group. One third of participants of intervention group had not found health benefit due to physical activity while in control group this number was more than half. After elderly received Group-Mediated Lifestyle Physical Activity program intervention for 6 month found significant statistical differences as compared with mean score at baseline (health benefit 6 month, intervention group =40.7 ± 34.28 and control group =4.56 ± 8.79). Conclusion: The effect of Group-Mediated Lifestyle Physical Activity program change intervention was statistically significant in health benefit after intervention program between intervention and control group. Our study

  10. and collider physics: Working group report

    Indian Academy of Sciences (India)

    Theory Group, Physical Research Laboratory, Navrangpura, Ahmedabad 380 ... One such is anomaly mediation, wherein there is no tree level coupling ..... The role of the spectator quarks effect in the inclusive beauty decays were studied.

  11. Interdependence and organizational citizenship behavior: exploring the mediating effect of group cohesion in multilevel analysis.

    Science.gov (United States)

    Chen, Chun-Hsi Vivian; Tang, Ya-Yun; Wang, Shih-Jon

    2009-12-01

    The authors investigated the mechanism of group cohesion in the relationship between (a) task interdependence and goal interdependence and (b) individuals' organizational citizenship behavior (OCB). The authors adopted a multilevel perspective to facilitate understanding of the complex relations among variables. They collected data from 53 supervisors and 270 employees from R&D departments in Taiwan. The authors found that group cohesion fully mediated the effects of task interdependence and goal interdependence on employees' OCB. In addition, task interdependence had a greater effect on group cohesion than did goal interdependence. The authors discuss implications and suggestions for future research.

  12. Problem of Office Suite Training at the University

    Directory of Open Access Journals (Sweden)

    Natalia A. Nastashchuk

    2013-01-01

    Full Text Available Te paper considers the problem of office suite applications training, caused by a rapid change of their versions, variety of software developers and a rapid development of software and hardware platforms. The content of office suite applications training, based on the system of office suite notions, its basic functional and standards of information technologies development (OpenDocument Format Standard, ISO 26300-200Х is presented.

  13. 46 CFR 199.214 - Immersion suits and thermal protective aids.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Immersion suits and thermal protective aids. 199.214... Passenger Vessels § 199.214 Immersion suits and thermal protective aids. (a) Each passenger vessel must... an immersion suit. (c) The immersion suits and thermal protective aids required under paragraphs (a...

  14. PLEASE: The Python Low-energy Electron Analysis SuitE – Enabling Rapid Analysis of LEEM and LEED Data

    Directory of Open Access Journals (Sweden)

    Maxwell Grady

    2018-02-01

    Full Text Available PLEASE, the Python Low-energy Electron Analysis SuitE, provides an open source and cross-platform graphical user interface (GUI for rapid analysis and visualization of low energy electron microscopy (LEEM data sets. LEEM and the associated technique, selected area micro-spot low energy electron diffraction (μ-LEED, are powerful tools for analysis of the surface structure for many novel materials. Specifically, these tools are uniquely suited for the characterization of two-dimensional materials. PLEASE offers a user-friendly point-and-click method for extracting intensity-voltage curves from LEEM and LEED data sets. Analysis of these curves provides insight into the atomic structure of the target material surface with unparalleled resolution.

  15. Measurement of Carbon Dioxide Accumulation and Physiological Function in the Launch and Entry and Advanced Crew Escape Suits

    Science.gov (United States)

    Bishop, Phillip; Greenisen, M. C.

    1997-01-01

    The Launch and Entry Suit (LES) and Advanced Crew Escape Suit (ACES) are worn by astronauts for launch and entry. Previous work by Waligora, et al., 1992, Waligora and Gilbert, 1992, and Dalrymple 1996, have found that carbon dioxide (CO2) accumulation in the LES/ACES helmet may be problematic. CO2 accumulation is important because high inspired levels of CO2 reduce physical function and pose a safety hazard (e.g. levels of CO2 accumulation of 3.6% in the Extravehicular Mobility Unit are sufficient to terminate Extra Vehicular Activities). My task was to design a suitable test protocol for determining the important physiological aspects of LES/ACES use. Three basic issues arose. First was the determination of the astronaut's CO2 inspiration during visor-down use at rest and during walking at 3.5 mph. A sub-issue was the impact of a pneumotach on CO2 since it has been previously observed that when the Aerosport pneumotach was used, performance seemed improved, which might be attributable to a lowered respiration rate when using the pneumotach. The second issue was the energy costs of waLking in the LES/ACES with various G-suit inflation levels, since G-suit inflation increases metabolic costs and metabolic costs influence the C02 production in the LES/ACES helmet. Since G-suit inflation improves orthostatic tolerance after space flight, but likely increases the energy costs of walking, the balance between G-suit inflation and C02 accumulation is an important safety consideration. The third issue which arose from pilot work was the substantial reduction in physical function after a 10 min visor-down period prior to walk.

  16. Developing models of how cognitive improvements change functioning: Mediation, moderation and moderated mediation

    Science.gov (United States)

    Wykes, Til; Reeder, Clare; Huddy, Vyv; Taylor, Rumina; Wood, Helen; Ghirasim, Natalia; Kontis, Dimitrios; Landau, Sabine

    2012-01-01

    Background Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown. Aim To develop and test models of how cognitive improvement transfers to work behaviour using the data from a current service. Method Participants (N49) with a support worker and a paid or voluntary job were offered CRT in a Phase 2 single group design with three assessments: baseline, post therapy and follow-up. Working memory, cognitive flexibility, planning and work outcomes were assessed. Results Three models were tested (mediation — cognitive improvements drive functioning improvement; moderation — post treatment cognitive level affects the impact of CRT on functioning; moderated mediation — cognition drives functioning improvements only after a certain level is achieved). There was evidence of mediation (planning improvement associated with improved work quality). There was no evidence that cognitive flexibility (total Wisconsin Card Sorting Test errors) and working memory (Wechsler Adult Intelligence Scale III digit span) mediated work functioning despite significant effects. There was some evidence of moderated mediation for planning improvement if participants had poorer memory and/or made fewer WCST errors. The total CRT effect on work quality was d = 0.55, but the indirect (planning-mediated CRT effect) was d = 0.082 Conclusion Planning improvements led to better work quality but only accounted for a small proportion of the total effect on work outcome. Other specific and non-specific effects of CRT and the work programme are likely to account for some of the remaining effect. This is the first time complex models have been tested and future Phase 3 studies need to further test mediation and moderated mediation models. PMID:22503640

  17. Accounting for sex differences in PTSD: A multi-variable mediation model

    Directory of Open Access Journals (Sweden)

    Dorte M. Christiansen

    2015-01-01

    Full Text Available Background: Approximately twice as many females as males are diagnosed with posttraumatic stress disorder (PTSD. However, little is known about why females report more PTSD symptoms than males. Prior studies have generally focused on few potential mediators at a time and have often used methods that were not ideally suited to test for mediation effects. Prior research has identified a number of individual risk factors that may contribute to sex differences in PTSD severity, although these cannot fully account for the increased symptom levels in females when examined individually. Objective: The present study is the first to systematically test the hypothesis that a combination of pre-, peri-, and posttraumatic risk factors more prevalent in females can account for sex differences in PTSD severity. Method: The study was a quasi-prospective questionnaire survey assessing PTSD and related variables in 73.3% of all Danish bank employees exposed to bank robbery during the period from April 2010 to April 2011. Participants filled out questionnaires 1 week (T1, N=450 and 6 months after the robbery (T2, N=368; 61.1% females. Mediation was examined using an analysis designed specifically to test a multiple mediator model. Results: Females reported more PTSD symptoms than males and higher levels of neuroticism, depression, physical anxiety sensitivity, peritraumatic fear, horror, and helplessness (the A2 criterion, tonic immobility, panic, dissociation, negative posttraumatic cognitions about self and the world, and feeling let down. These variables were included in the model as potential mediators. The combination of risk factors significantly mediated the association between sex and PTSD severity, accounting for 83% of the association. Conclusions: The findings suggest that females report more PTSD symptoms because they experience higher levels of associated risk factors. The results are relevant to other trauma populations and to other trauma

  18. Mediatization: a concept, multiple voices

    Directory of Open Access Journals (Sweden)

    Pedro Gilberto GOMES

    2016-12-01

    Full Text Available Mediatization has become increasingly a key concept, fundamental, essential to describe the present and the history of media and communicative change taking place. Thus, it became part of a whole, one can not see them as a separate sphere. In this perspective, the media coverage is used as a concept to describe the process of expansion of the different technical means and consider the interrelationships between the communicative change, means and sociocultural change. However, although many researchers use the concept of mediatization, each gives you the meaning that best suits your needs. Thus, the concept of media coverage is treated with multiple voices. This paper discusses this problem and present a preliminary pre-position on the matter.

  19. Vibrotactile perception assessment for a haptic interface on an antigravity suit.

    Science.gov (United States)

    Ko, Sang Min; Lee, Kwangil; Kim, Daeho; Ji, Yong Gu

    2017-01-01

    Haptic technology is used in various fields to transmit information to the user with or without visual and auditory cues. This study aimed to provide preliminary data for use in developing a haptic interface for an antigravity (anti-G) suit. With the structural characteristics of the anti-G suit in mind, we determined five areas on the body (lower back, outer thighs, inner thighs, outer calves, and inner calves) on which to install ten bar-type eccentric rotating mass (ERM) motors as vibration actuators. To determine the design factors of the haptic anti-G suit, we conducted three experiments to find the absolute threshold, moderate intensity, and subjective assessments of vibrotactile stimuli. Twenty-six fighter pilots participated in the experiments, which were conducted in a fixed-based flight simulator. From the results of our study, we recommend 1) absolute thresholds of ∼11.98-15.84 Hz and 102.01-104.06 dB, 2) moderate intensities of 74.36 Hz and 126.98 dB for the lower back and 58.65 Hz and 122.37 dB for either side of the thighs and calves, and 3) subjective assessments of vibrotactile stimuli (displeasure, easy to perceive, and level of comfort). The results of this study will be useful for the design of a haptic anti-G suit. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. A new device for the inflation of the antigravity suit.

    Science.gov (United States)

    Brodrick, P M

    1986-02-01

    The 'Schuco' orthopaedic tourniquet inflator can be simply converted into a suitable device for inflating an antigravity suit (G-suit). The antigravity suit may be used on neurosurgical patients undergoing procedures in the sitting position to help prevent hypotension and air embolism. The availability of this device may encourage the more widespread use of an antigravity suit in neuro-anaesthetic practice.

  1. Mercury levels in defined Italian population groups

    International Nuclear Information System (INIS)

    Ingrao, G.; Belloni, P.

    1992-01-01

    The consumption of fish and seafood usually is the main source of intake of methylmercury for members of the general population. Therefore subjects having a diet rich in these food items present a high risk of exceeding the tolerable recommended weekly intake of mercury set by FAO and WHO. The average consumption of fish at a national level is rather small in Italy, 12.5 kg per year, consequently the risk of exposure to elevated levels of mercury through the diet for members of the Italian general population is rather negligible. However, fish is one of the main components of the diet of some population groups. These groups are usually found in coastal towns close fishing ports and include subjects working as fishermen, fish dealers, restaurant workers and their families. The purpose of this research programme, carried our with the collaboration of the National Institute of Nutrition is to determine the levels of mercury and methylmercury in hair samples of subjects having a higher than average fish consumption and to evaluate the effects of elevated intakes of mercury. 1 ref., 13 figs

  2. Exploring individual cognitions, self-regulation skills, and environmental-level factors as mediating variables of two versions of a Web-based computer-tailored nutrition education intervention aimed at adults: A randomized controlled trial.

    Science.gov (United States)

    Springvloet, Linda; Lechner, Lilian; Candel, Math J J M; de Vries, Hein; Oenema, Anke

    2016-03-01

    This study explored whether the determinants that were targeted in two versions of a Web-based computer-tailored nutrition education intervention mediated the effects on fruit, high-energy snack, and saturated fat intake among adults who did not comply with dietary guidelines. A RCT was conducted with a basic (tailored intervention targeting individual cognitions and self-regulation), plus (additionally targeting environmental-level factors), and control group (generic nutrition information). Participants were recruited from the general Dutch adult population and randomly assigned to one of the study groups. Online self-reported questionnaires assessed dietary intake and potential mediating variables (behavior-specific cognitions, action- and coping planning, environmental-level factors) at baseline and one (T1) and four (T2) months post-intervention (i.e. four and seven months after baseline). The joint-significance test was used to establish mediating variables at different time points (T1-mediating variables - T2-intake; T1-mediating variables - T1-intake; T2-mediating variables - T2-intake). Educational differences were examined by testing interaction terms. The effect of the plus version on fruit intake was mediated (T2-T2) by intention and fruit availability at home and for high-educated participants also by attitude. Among low/moderate-educated participants, high-energy snack availability at home mediated (T1-T1) the effect of the basic version on high-energy snack intake. Subjective norm mediated (T1-T1) the effect of the basic version on fat intake among high-educated participants. Only some of the targeted determinants mediated the effects of both intervention versions on fruit, high-energy snack, and saturated fat intake. A possible reason for not finding a more pronounced pattern of mediating variables is that the educational content was tailored to individual characteristics and that participants only received feedback for relevant and not for all

  3. Development on smart suit for dairy work assistance.

    Science.gov (United States)

    Nara, Hiroyuki; Kusaka, Takashi; Tanaka, Takayuki; Yamagishi, Takayuki; Ogura, Shotaroh

    2013-01-01

    Our purpose in this study is to achieve an independent life and a social involvement for the elderly using KEIROKA Technology(fatigue-reduction) which makes it possible to improve the quality of chores and occupations by removing excessive strain and tiredness. The authors have developed power assist suits named "smart suit". The authors have evaluated the effect that the purpose of dairy work assistance, to measure EMG of the worker, compared to the potential of the surface of the non-wearing and wearing "smart suit".

  4. Comparison of folic acid levels in schizophrenic patients and control groups

    Science.gov (United States)

    Arthy, C. C.; Amin, M. M.; Effendy, E.

    2018-03-01

    Folic acid deficiency is a risk factor for schizophrenia through epidemiology, biochemistry and gene-related studies. Compared with healthy people, schizophrenic patients may have high homocysteine plasma values and homocysteine or low levels of folic acid, which seems to correlate with extrapyramidal motor symptoms caused by neuroleptic therapy and with symptoms of schizophrenia. In this present study, we focus on the difference of folic acid level between schizophrenic patient and control group. The study sample consisted of schizophrenic patients and 14 people in the control group and performed blood sampling to obtain the results of folic acid levels. The folic acid level in both groups was within normal range, but the schizophrenic patient group had lower mean folic acid values of 5.00 ng/ml (sb 1.66), compared with the control group with mean folic acid values of 10.75 ng/ml (sb 4.33). there was the group of the control group had a higher value of folic acid than the schizophrenic group.

  5. Inferring Group Processes from Computer-Mediated Affective Text Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Schryver, Jack C [ORNL; Begoli, Edmon [ORNL; Jose, Ajith [Missouri University of Science and Technology; Griffin, Christopher [Pennsylvania State University

    2011-02-01

    Political communications in the form of unstructured text convey rich connotative meaning that can reveal underlying group social processes. Previous research has focused on sentiment analysis at the document level, but we extend this analysis to sub-document levels through a detailed analysis of affective relationships between entities extracted from a document. Instead of pure sentiment analysis, which is just positive or negative, we explore nuances of affective meaning in 22 affect categories. Our affect propagation algorithm automatically calculates and displays extracted affective relationships among entities in graphical form in our prototype (TEAMSTER), starting with seed lists of affect terms. Several useful metrics are defined to infer underlying group processes by aggregating affective relationships discovered in a text. Our approach has been validated with annotated documents from the MPQA corpus, achieving a performance gain of 74% over comparable random guessers.

  6. NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Sensor Data Record (SDR) from IDPS

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Sensor Data Records (SDRs), or Level 1b data, from the Visible Infrared Imaging Radiometer Suite (VIIRS) are the calibrated and geolocated radiance and reflectance...

  7. Immersion Suit Usage Within the RAAF

    Science.gov (United States)

    1992-01-01

    IMMERSION SUIT USED UVIC QDIS HOLDINGS 202. in 12 Sizes, held by ALSS 492SQN REQUIREMENTS No comment USAGE POLICY REFERENCE DIRAF) AAP 7215.004-1 (P3C...held by ALSS 492SQN. REQUIREMENTS No comment ISACE POLICY REFERENCE DIIAF) AAP 7215.004-1 (P3C Flight Manual) RAAF Supplement No 92 USAGE POUICY UVIC...TYPE P3C REFERENCE Telecon FLTLT Toft I I SQNfRESO AVMED Dated 22 Mar 91 IMMERSION SUIT USED UVIC QDIS HOLDINGS No comment REQUIREMENTS No comment USAGE

  8. Maternal educational level and preschool children's consumption of high-calorie snacks and sugar-containing beverages: mediation by the family food environment.

    Science.gov (United States)

    Wijtzes, Anne I; Jansen, Wilma; Jansen, Pauline W; Jaddoe, Vincent W V; Hofman, Albert; Raat, Hein

    2013-11-01

    To examine the associations between maternal educational level and preschoolers' consumption of high-calorie snacks and sugar-containing beverages, and to assess the mediating effects of variables relating to the family food environment. We analyzed data from 2814 native Dutch preschoolers enrolled in a birth cohort study in Rotterdam (the Netherlands), between 2002 and 2006. Logistic regression models were used to calculate odds ratios of snacking ≥ 2 times/day and consuming sugar-containing beverages ≥ 3 glasses/day for children of mothers with low, mid-low, and mid-high educational levels (reference group: high educational level), before and after adjustment for mediators. Children of low and mid-low educated mothers were significantly more likely to consume excessive amounts of high-calorie snacks and sugar-containing beverages compared with children of high educated mothers, with the highest odds in children of low educated mothers (OR: 2.44; 95% CI: 1.84, 3.23 and OR: 2.46; 95% CI: 1.87, 3.24 respectively). Parental feeding practices, parental consumption of sugar-containing beverages, and children's television time partly explained these associations. Maternal educational level is inversely related to preschoolers' consumption of high-calorie snacks and sugar-containing beverages. Targeting the family food environment may be an effective way of reducing educational inequalities in children's unhealthy dietary behaviors. © 2013.

  9. Advanced Sensor Platform to Evaluate Manloads for Exploration Suit Architectures

    Data.gov (United States)

    National Aeronautics and Space Administration — Space suit manloads are defined as the outer bounds of force that the human occupant of a suit is able to exert onto the suit during motion. They are defined on a...

  10. Engaging Élitism: The Mediating Effect of Work Engagement on Affective Commitment and Quit Intentions in Two Australian University Groups

    Science.gov (United States)

    Ferrer, Justine L.; Morris, Leanne

    2013-01-01

    Some universities rely on their élitism as one mechanism to attract and retain talented faculty. This paper examines two groups of élite and non-élite universities and the mediating effect that work engagement has on affective commitment and intention to quit. Findings indicate partial support for the mediating effect of work engagement in the…

  11. Psychosocial group rehabilitation for lonely older people: favourable processes and mediating factors of the intervention leading to alleviated loneliness.

    Science.gov (United States)

    Savikko, Niina; Routasalo, Pirkko; Tilvis, Reijo; Pitkälä, Kaisu

    2010-03-01

    Loneliness among community-dwelling older people is a common problem, with serious health consequences. The favourable processes and mediating factors of a psychosocial group rehabilitation intervention in alleviating older people's loneliness were evaluated. Altogether, 117 lonely, home-dwelling individuals (aged ≥75 years) participated in a psychosocial group rehabilitation intervention. The content comprised (i) art and inspiring activities, (ii) group exercise and discussions or (iii) therapeutic writing and group therapy. The psychosocial group rehabilitation intervention was evaluated from the group leaders' diaries and by observing the groups. Experiences of loneliness and social participation were collected by postintervention questionnaires from the participants. Data were analysed using methodological triangulation. Doing things together and sharing experiences with their peers inspired lively discussions, created a feeling of togetherness and led to participants' empowerment and increased self-esteem. The intervention socially activated the participants, and their feelings of loneliness had been alleviated during the intervention. Several common favourable processes and mediating factors were identified in the psychosocial group rehabilitation intervention that led to alleviation of loneliness among older people. Relevance to clinical practice.  The psychosocial group rehabilitation intervention gives nurses an effective tool to support older people's psychosocial resources by activating them and alleviating their loneliness. © 2009 Blackwell Publishing Ltd.

  12. Assessing the relationships among stress, god-mediated control, and psychological distress/well-being: Does the level of education matter?

    Science.gov (United States)

    Krause, Neal

    2018-01-24

    One of the primary functions of religion is to help people cope with stressful life events. The purpose of the current study is to see if God-mediated control beliefs perform this stress-buffering function. God-mediated control refers to the belief that people work together with God to reduce the effects of unwanted stressors in their lives. An effort is made to probe this relationship more deeply by seeing whether the stress moderating function of God-mediated control beliefs varies across levels of educational attainment. Findings from a recent nationwide survey suggest that strong God-mediated control beliefs reduce the magnitude of the relationship between stress and depressive symptoms, anxiety, happiness, and hope, but only among more highly educated study participants. In contrast, God-mediated control beliefs do not appear to influence the relationship between stress and distress/well-being among study participants with lower levels of educational attainment.

  13. Alterations in MAST suit pressure with changes in ambient temperature.

    Science.gov (United States)

    Sanders, A B; Meislin, H W; Daub, E

    1983-01-01

    A study was undertaken to test the hypothesis that change in ambient air temperature has an effect on MAST suit pressure according to the ideal gas law. Two different MAST suits were tested on Resusci-Annie dummies. The MAST suits were applied in a cold room at 4.4 degrees C and warmed to 44 degrees C. Positive linear correlations were found in nine trials, but the two suits differed in their rate of increase in pressure. Three trials using humans were conducted showing increased pressure with temperature but at a lesser rate than with dummies. A correlation of 0.5 to 1.0 mm Hg increase in MAST suit pressure for each 1.0 degrees C increase in ambient temperature was found. Implications are discussed for the use of the MAST suit in environmental conditions where the temperature changes.

  14. Vitamin D Levels in Different Severity Groups of Schizophrenia.

    Science.gov (United States)

    Akinlade, Kehinde Sola; Olaniyan, Oyejide Afolabi; Lasebikan, Victor Olufolahan; Rahamon, Sheu Kadiri

    2017-01-01

    Vitamin D deficiency (VDD) continues to be associated with schizophrenia, but there is the dearth of information on the relationship between the severity of schizophrenia and plasma levels of vitamin D. This study, therefore, determined the plasma levels of vitamin D in different severity groups of schizophrenia. Plasma level of vitamin D was determined in 60 patients with schizophrenia and 30 apparently healthy individuals who served as controls. Patients with schizophrenia were classified into mildly ill, moderately ill, markedly ill, and severely ill groups using the Positive and Negative Syndrome Scale (PANSS). The mean level of vitamin D was significantly lower in patients with schizophrenia compared with the controls. Similarly, there was a significant association between VDD and schizophrenia. The mean plasma levels of vitamin D were not significantly different when the mildly, moderately, markedly, and severely ill groups were compared with one another and there was no significant correlation between vitamin D level and PANSS scores. Furthermore, patients on atypical antipsychotics had an insignificantly lower level of vitamin D compared with the patients on typical antipsychotics. It could be concluded from this study that patients with schizophrenia have low plasma vitamin D level which does not appear to be associated with the severity of schizophrenia and type of antipsychotics. Therefore, regular screening for vitamin D status of patients with schizophrenia is suggested in order to allow for the institution of appropriate clinical intervention when necessary.

  15. Vitamin D Levels in Different Severity Groups of Schizophrenia

    Directory of Open Access Journals (Sweden)

    Kehinde Sola Akinlade

    2017-06-01

    Full Text Available BackgroundVitamin D deficiency (VDD continues to be associated with schizophrenia, but there is the dearth of information on the relationship between the severity of schizophrenia and plasma levels of vitamin D. This study, therefore, determined the plasma levels of vitamin D in different severity groups of schizophrenia.Materials and methodsPlasma level of vitamin D was determined in 60 patients with schizophrenia and 30 apparently healthy individuals who served as controls. Patients with schizophrenia were classified into mildly ill, moderately ill, markedly ill, and severely ill groups using the Positive and Negative Syndrome Scale (PANSS.ResultsThe mean level of vitamin D was significantly lower in patients with schizophrenia compared with the controls. Similarly, there was a significant association between VDD and schizophrenia. The mean plasma levels of vitamin D were not significantly different when the mildly, moderately, markedly, and severely ill groups were compared with one another and there was no significant correlation between vitamin D level and PANSS scores. Furthermore, patients on atypical antipsychotics had an insignificantly lower level of vitamin D compared with the patients on typical antipsychotics.ConclusionIt could be concluded from this study that patients with schizophrenia have low plasma vitamin D level which does not appear to be associated with the severity of schizophrenia and type of antipsychotics. Therefore, regular screening for vitamin D status of patients with schizophrenia is suggested in order to allow for the institution of appropriate clinical intervention when necessary.

  16. Mediation in dyadic data at the level of the dyads: a Structural Equation Modeling approach.

    Science.gov (United States)

    Ledermann, Thomas; Macho, Siegfried

    2009-10-01

    An extended version of the Common Fate Model (CFM) is presented to estimate and test mediation in dyadic data. The model can be used for distinguishable dyad members (e.g., heterosexual couples) or indistinguishable dyad members (e.g., homosexual couples) if (a) the variables measure characteristics of the dyadic relationship or shared external influences that affect both partners; if (b) the causal associations between the variables should be analyzed at the dyadic level; and if (c) the measured variables are reliable indicators of the latent variables. To assess mediation using Structural Equation Modeling, a general three-step procedure is suggested. The first is a selection of a good fitting model, the second a test of the direct effects, and the third a test of the mediating effect by means of bootstrapping. The application of the model along with the procedure for assessing mediation is illustrated using data from 184 couples on marital problems, communication, and marital quality. Differences with the Actor-Partner Interdependence Model and the analysis of longitudinal mediation by using the CFM are discussed.

  17. Permutation groups

    CERN Document Server

    Passman, Donald S

    2012-01-01

    This volume by a prominent authority on permutation groups consists of lecture notes that provide a self-contained account of distinct classification theorems. A ready source of frequently quoted but usually inaccessible theorems, it is ideally suited for professional group theorists as well as students with a solid background in modern algebra.The three-part treatment begins with an introductory chapter and advances to an economical development of the tools of basic group theory, including group extensions, transfer theorems, and group representations and characters. The final chapter feature

  18. UNEARTHING GLOBAL FINANCIAL INCLUSION LEVELS AND ANALYSIS OF FINANCIAL INCLUSION AS A MEDIATING FACTOR IN GLOBAL HUMAN DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Roshny Unnikrishnan

    2015-04-01

    Full Text Available This study is a result of the author’s inquisition to unearth the current values of Global Financial Inclusion and its relationship with economic growth measured by Gross Domestic product(GDP and human development measured by United Nations Human Development Index (HDI. The Financial Inclusion (FI levels are measured using Index for Financial Inclusion .The relationship between GDP and HDI with FI as mediator, using multiple regression, is validated on a global level based on data of 162 countries for the year 2011. An overall global mediation analysis is undertaken to establish Financial Inclusion as a mediating factor and partial mediation on human development is validated. The study is valid and unique in the global context of income inequality prevailing in developed, developing and underdeveloped countries as it validates the argument that an impressive GDP performance does not ensure equity in economic growth.

  19. Satellite Ocean Heat Content Suite

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This collection contains an operational Satellite Ocean Heat Content Suite (SOHCS) product generated by NOAA National Environmental Satellite, Data, and Information...

  20. EVA Suit Microbial Leakage Investigation

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this project is to collect microbial samples from various EVA suits to determine how much microbial contamination is typically released during...

  1. Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways.

    Directory of Open Access Journals (Sweden)

    Yu Xiao

    Full Text Available Cre-mediated excision of loxP sites is widely used in mice to manipulate gene function in a tissue-specific manner. To analyze phenotypic alterations related to Cre-expression, we have used AMH-Cre-transgenic mice as a model system. Different Cre expression levels were obtained by investigation of C57BL/6J wild type as well as heterozygous and homozygous AMH-Cre-mice. Our results indicate that Cre-expression itself in Sertoli cells already has led to oxidative stress and lipid peroxidation (4-HNE lysine adducts, inducing PPARα/γ, peroxisome proliferation and alterations of peroxisome biogenesis (PEX5, PEX13 and PEX14 as well as metabolic proteins (ABCD1, ABCD3, MFP1, thiolase B, catalase. In addition to the strong catalase increase, a NRF2- and FOXO3-mediated antioxidative response (HMOX1 of the endoplasmic reticulum and mitochondrial SOD2 and a NF-κB activation were noted. TGFβ1 and proinflammatory cytokines like IL1, IL6 and TNFα were upregulated and stress-related signaling pathways were induced. Sertoli cell mRNA-microarray analysis revealed an increase of TNFR2-signaling components. 53BP1 recruitment and expression levels for DNA repair genes as well as for p53 were elevated and the ones for related sirtuin deacetylases affected (SIRT 1, 3-7 in Sertoli cells. Under chronic Cre-mediated DNA damage conditions a strong downregulation of Sirt1 was observed, suggesting that the decrease of this important coordinator between DNA repair and metabolic signaling might induce the repression release of major transcription factors regulating metabolic and cytokine-mediated stress pathways. Indeed, caspase-3 was activated and increased germ cell apoptosis was observed, suggesting paracrine effects. In conclusion, the observed wide stress-induced effects and metabolic alterations suggest that it is essential to use the correct control animals (Cre/Wt with matched Cre expression levels to differentiate between Cre-mediated and specific gene-knock out-mediated

  2. Cre-Mediated Stress Affects Sirtuin Expression Levels, Peroxisome Biogenesis and Metabolism, Antioxidant and Proinflammatory Signaling Pathways

    Science.gov (United States)

    Xiao, Yu; Karnati, Srikanth; Qian, Guofeng; Nenicu, Anca; Fan, Wei; Tchatalbachev, Svetlin; Höland, Anita; Hossain, Hamid; Guillou, Florian; Lüers, Georg H.; Baumgart-Vogt, Eveline

    2012-01-01

    Cre-mediated excision of loxP sites is widely used in mice to manipulate gene function in a tissue-specific manner. To analyze phenotypic alterations related to Cre-expression, we have used AMH-Cre-transgenic mice as a model system. Different Cre expression levels were obtained by investigation of C57BL/6J wild type as well as heterozygous and homozygous AMH-Cre-mice. Our results indicate that Cre-expression itself in Sertoli cells already has led to oxidative stress and lipid peroxidation (4-HNE lysine adducts), inducing PPARα/γ, peroxisome proliferation and alterations of peroxisome biogenesis (PEX5, PEX13 and PEX14) as well as metabolic proteins (ABCD1, ABCD3, MFP1, thiolase B, catalase). In addition to the strong catalase increase, a NRF2- and FOXO3-mediated antioxidative response (HMOX1 of the endoplasmic reticulum and mitochondrial SOD2) and a NF-κB activation were noted. TGFβ1 and proinflammatory cytokines like IL1, IL6 and TNFα were upregulated and stress-related signaling pathways were induced. Sertoli cell mRNA-microarray analysis revealed an increase of TNFR2-signaling components. 53BP1 recruitment and expression levels for DNA repair genes as well as for p53 were elevated and the ones for related sirtuin deacetylases affected (SIRT 1, 3-7) in Sertoli cells. Under chronic Cre-mediated DNA damage conditions a strong downregulation of Sirt1 was observed, suggesting that the decrease of this important coordinator between DNA repair and metabolic signaling might induce the repression release of major transcription factors regulating metabolic and cytokine-mediated stress pathways. Indeed, caspase-3 was activated and increased germ cell apoptosis was observed, suggesting paracrine effects. In conclusion, the observed wide stress-induced effects and metabolic alterations suggest that it is essential to use the correct control animals (Cre/Wt) with matched Cre expression levels to differentiate between Cre-mediated and specific gene-knock out-mediated

  3. Study of the suit inflation effect on crew safety during landing using a full-pressure IVA suit for new-generation reentry space vehicles

    Science.gov (United States)

    Wataru, Suzuki

    Recently, manned space capsules have been recognized as beneficial and reasonable human space vehicles again. The Dragon capsule already achieved several significant successes. The Orion capsule is going to be sent to a high-apogee orbit without crews for experimental purposes in September 2014. For such human-rated space capsules, the study of acceleration impacts against the human body during splashdown is essential to ensure the safety of crews. Moreover, it is also known that wearing a full pressure rescue suit significantly increases safety of a crew, compared to wearing a partial pressure suit. This is mainly because it enables the use of a personal life support system independently in addition to that which installed in the space vehicle. However, it is unclear how the inflation of the full pressure suit due to pressurization affects the crew safety during splashdown, especially in the case of the new generation manned space vehicles. Therefore, the purpose of this work is to investigate the effect of the suit inflation on crew safety against acceleration impact during splashdown. For this objective, the displacements of the safety harness in relation with the suit, a human surrogate, and the crew seats during pressurizing the suit in order to determine if the safety and survivability of a crew can be improved by wearing a full pressure suit. For these tests, the DL/H-1 full pressure IVA suit, developed by Pablo de Leon and Gary L. Harris, will be used. These tests use image analysis techniques to determine the displacements. It is expected, as a result of these tests, that wearing a full pressure suit will help to mitigate the impacts and will increase the safety and survivability of a crew during landing since it works as a buffer to mitigate impact forces during splashdown. This work also proposes a future plan for sled test experiments using a sled facility such as the one in use by the Civil Aerospace Medical Institute (CAMI) for experimental validation

  4. EVA Physiology and Medical Considerations Working in the Suit

    Science.gov (United States)

    Parazynski, Scott

    2012-01-01

    This "EVA Physiology and Medical Considerations Working in the Suit" presentation covers several topics related to the medical implications and physiological effects of suited operations in space from the perspective of a physician with considerable first-hand Extravehicular Activity (EVA) experience. Key themes include EVA physiology working in a pressure suit in the vacuum of space, basic EVA life support and work support, Thermal Protection System (TPS) inspections and repairs, and discussions of the physical challenges of an EVA. Parazynski covers the common injuries and significant risks during EVAs, as well as physical training required to prepare for EVAs. He also shares overall suit physiological and medical knowledge with the next generation of Extravehicular Mobility Unit (EMU) system designers.

  5. Get the lead out: Wildlife advocates file suit to replace toxic ammo ...

    African Journals Online (AJOL)

    2007-03-02

    Mar 2, 2007 ... Get the lead out: Wildlife advocates file suit to replace toxic ammo with safer alternatives. Simple, practical ... who eats game, which often contains shot or small metal fragments. Lead is an extremely toxic ... eating meat from animals taken with lead ammunition often have unhealthy lead levels in their own ...

  6. Relationships between cohesion, collective efficacy and performance in professional basketball teams: an examination of mediating effects.

    Science.gov (United States)

    Heuzé, Jean-Philippe; Raimbault, Nicolas; Fontayne, Paul

    2006-01-01

    The main aim of this study was to examine mediating effects in the relationships between cohesion, collective efficacy and performance in professional basketball teams. A secondary aim was to examine the correlates of collective efficacy in a professional sport. A total of 154 French and foreign professional players completed French or English versions of questionnaires about cohesion and collective efficacy. Two composite measures of individual performance were used (pre- and post-performance). Individual-level analyses were performed. Regression analyses supported two mediating relationships with collective efficacy as a mediator of the pre-performance - Group integration-task relationship, and Group integration-task as a mediator of the pre-performance - collective efficacy relationship. Statistical analyses indicated that neither Group integration-task nor collective efficacy was a better mediator in the relationship between pre-performance and the other group variables. Results also revealed positive relationships between three dimensions of cohesion (i.e. Individual attractions to the group-task, Group integration-task, Group integration-social) and collective efficacy. These findings suggest that in professional basketball teams, staff members should look after athletes who perform at a lower or below their usual level because their performances might lead them into a downward cohesion - collective efficacy spiral. Staff members should also develop a high quality of group functioning, both on and off the basketball court, given its relationship with collective efficacy.

  7. Personnel protective equipment total-encapsulating suit decontamination study using shower systems

    International Nuclear Information System (INIS)

    Menkhaus, D.E.

    1991-01-01

    This report documents an experimental evaluation, conducted at the Idaho National Engineering Laboratory, of a shower-based decontamination station for personnel wearing a Level A, total- encapsulating, chemical-protective suit. The decontamination station is used by personnel when egressing a dry, dusty environment contaminated with transuranic radionuclides. This system has the potential to minimize the risk of spreading the contaminants to clean areas. Two types of shower systems were evaluated, a drench shower and a multi-nozzle shower. A total-encapsulating suit, worn by personnel. was contaminated with soil containing 239 Pu. Pre- shower and post-shower contamination samples were collected and visual observations were made to evaluate the ability of the shower system to remove the contaminated dust and to obtain baseline data useful in designing a shower-based personnel decontamination system. 12 figs., 7 tabs

  8. The BRITNeY Suite: A Platfor for Experiments

    DEFF Research Database (Denmark)

    Westergaard, Michael

    2006-01-01

    This paper describes a platform, the BRITNeY Suite, for experimenting with Coloured Petri nets. The BRITNeY Suite provides access to data-structures and a simulator for Coloured Petri nets via a powerful scripting language and plug-in-mechanism, thereby making it easy to perform customized...

  9. EDL Sensor Suite, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Optical Air Data Systems (OADS) L.L.C. proposes a LIDAR based remote measurement sensor suite capable of satisfying a significant number of the desired sensing...

  10. The Chernobyl cloud: comments on a non-suit

    International Nuclear Information System (INIS)

    2011-01-01

    This article comments the non-suit decision taken by a Paris court at the benefit of Pierre Pellerin after a trial about his declarations concerning the Chernobyl cloud. It recalls the great number of controls of radioactive contamination levels performed in France at this time by the SCRPI with Mr Pellerin at its head. It states that French authorities behaved like other European authorities with respect to the contamination brought by the cloud, that no epidemiological study has ever revealed pathologies which could be due to the cloud, and that the increase of cancers in Corsica is not proved

  11. [Maximal exercise in spinal cord injured subjects: effects of an antigravity suit].

    Science.gov (United States)

    Bazzi-Grossin, C; Bonnin, P; Bailliart, O; Bazzi, H; Kedra, A W; Martineaud, J P

    1996-01-01

    Paraplegics have low aerobic capacity because of the spinal cord injury. Their functional muscle mass is reduced and usually untrained. They have to use upperbody muscles for displacements and daily activities. Sympathic nervous system injury is responsible of vasomotricity disturbances in leg vessels and possible abdominal vessels, proportionally to level injury. If cord injury level is higher than T5, then sympathic cardiac efferences may be damaged. Underbody muscles atrophy and vasomotricity disturbances contribute to phlebostasis. This stasis may decrease venous return, preload and stroke volume (Starling). To maintain appropriate cardiac output, tachycardia is necessary, especially during exercise. Low stroke volume, all the more since it is associated with cardio-acceleration disturbances, may reduce cardiac output reserve, and so constitutes a limiting factor for adaptation to exercise. The aim of this study was to verify if use of an underlesional pressure suit may increase cardiac output reserve because of lower venous stasis, and increase performance. We studied 10 able-bodied and 14 traumatic paraplegic subjects. Able-bodied subjects were 37 +/- 6 years old, wellbeing, not especially trained with upperbody muscles: there were 2 women and 8 men. Paraplegics were 27 +/- 7 years old, wellbeing except paraplegia, five of them practiced sport regularly (athletism or basket for disabled), and the others just daily propelled their wheelchair; there were 5 women and 9 men. For 8 of them, cord injury levels were located below T7, between T1 and T6 for the others. The age disability varied from 6 months to 2 years for 9 of them, it was approximately five years for 4 of them, and 20 years for one. We used a maximal triangular arm crank exercise with an electro-magnetic ergocycle Gauthier frame. After five minutes warm up, it was proceeded in one minute successive stages until maximal oxygen consumption is raised. VO2, VCO2, RER were measured by direct method with

  12. Functional Mobility Testing: A Novel Method to Create Suit Design Requirements

    Science.gov (United States)

    England, Scott A.; Benson, Elizabeth A.; Rajulu, Sudhakar L.

    2008-01-01

    This study was performed to aide in the creation of design requirements for the next generation of space suits that more accurately describe the level of mobility necessary for a suited crewmember through the use of an innovative methodology utilizing functional mobility. A novel method was utilized involving the collection of kinematic data while 20 subjects (10 male, 10 female) performed pertinent functional tasks that will be required of a suited crewmember during various phases of a lunar mission. These tasks were selected based on relevance and criticality from a larger list of tasks that may be carried out by the crew. Kinematic data was processed through Vicon BodyBuilder software to calculate joint angles for the ankle, knee, hip, torso, shoulder, elbow, and wrist. Maximum functional mobility was consistently lower than maximum isolated mobility. This study suggests that conventional methods for establishing design requirements for human-systems interfaces based on maximal isolated joint capabilities may overestimate the required mobility. Additionally, this method provides a valuable means of evaluating systems created from these requirements by comparing the mobility available in a new spacesuit, or the mobility required to use a new piece of hardware, to this newly established database of functional mobility.

  13. The mediating role of the home environment in relation to parental educational level and preschool children’s screen time: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Suvi Määttä

    2017-09-01

    Full Text Available Abstract Background Previous studies suggest that preschoolers from low socioeconomic backgrounds engage in more screen time. Still, the factors in the social and physical home environment driving these differences in preschool children’s screen time are poorly understood. This study examines potential home environment mediators in the associations between parental educational level and preschoolers’ screen time. Methods A total of 864 children aged 3–6 years and their parents participated in a cross-sectional DAGIS study in 2015–2016. Parents recorded their children’s screen time in a diary (N = 823. For the analyses, the daily average screen time at home was calculated. Parental questionnaires (N = 808 assessed educational level and eight social and physical environment factors in the home (i.e., descriptive norm for children’s screen time, parental screen use in front of children, parental importance for limiting children’s screen time, parental attitude toward societal pressures for children’s screen time, access to screens at home, parental self-efficacy for limiting children’s screen time, satisfaction of children’s screen time, and rules for limiting children’s screen time. Parental education was grouped into low, middle, and high education. The associations were tested by conducting mediation analyses adjusted by season and children’s sex and age. The significant mediators in the single-mediator models were included in the final multiple-mediator models. Results Of the potential eight mediators, the following four had a significant indirect association: descriptive norm for children’s screen time, parental screen use in front of children, parental importance for limiting children’s screen time, and parental attitude toward societal pressures for children’s screen time. Parents with high education had lower descriptive norm and used fewer screens in front of children compared to parents with middle or

  14. Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators

    Directory of Open Access Journals (Sweden)

    Arthur Dyer

    2017-03-01

    Full Text Available Enadenotucirev (EnAd is a chimeric group B adenovirus isolated by bioselection from a library of adenovirus serotypes. It replicates selectively in and kills a diverse range of carcinoma cells, shows effective anticancer activity in preclinical systems, and is currently undergoing phase I/II clinical trials. EnAd kills cells more quickly than type 5 adenovirus, and speed of cytotoxicity is dose dependent. The EnAd death pathway does not involve p53, is predominantly caspase independent, and appears to involve a rapid fall in cellular ATP. Infected cells show early loss of membrane integrity; increased exposure of calreticulin; extracellular release of ATP, HSP70, and HMGB1; and influx of calcium. The virus also causes an obvious single membrane blister reminiscent of ischemic cell death by oncosis. In human tumor biopsies maintained in ex vivo culture, EnAd mediated release of pro-inflammatory mediators such as TNF-α, IL-6, and HMGB1. In accordance with this, EnAd-infected tumor cells showed potent stimulation of dendritic cells and CD4+ T cells in a mixed tumor-leukocyte reaction in vitro. Whereas many viruses have evolved for efficient propagation with minimal inflammation, bioselection of EnAd for rapid killing has yielded a virus with a short life cycle that combines potent cytotoxicity with a proinflammatory mechanism of cell death.

  15. Variable Vector Countermeasure Suit for Space Habitation and Exploration

    Data.gov (United States)

    National Aeronautics and Space Administration — The "Variable Vector Countermeasure Suit (V2Suit) for Space Habitation and Exploration" is a visionary system concept that will revolutionize space missions by...

  16. NetSuite OneWorld Implementation 2011 R2

    CERN Document Server

    Foydel, Thomas

    2011-01-01

    This book is a focused, step-by step tutorial that shows you how to successfully implement NetSuite OneWorld into your organization. It is written in an easy-to-read style, with a strong emphasis on real-world, practical examples with step-by-step explanations. The book focuses on NetSuite OneWorld 2011 R1. If you are an application administrator, business analyst, project team member or business process owner who wants to implement NetSuite OneWorld into your organization, then this book is for you. This book might also be useful if you are a business manager considering a new system for your

  17. Prokofieff: Krieg und Frieden (Sinfonische Suite), Die Verlobung im Kloster (Sommernacht-Suite), Russische Overtüre. Philharmonia Orchestra, Neeme Järvi / G. W.

    Index Scriptorium Estoniae

    G. W.

    1993-01-01

    Uuest heliplaadist "Prokofieff: Krieg und Frieden (Sinfonische Suite), Die Verlobung im Kloster (Sommernacht-Suite), Russische Overtüre. Philharmonia Orchestra, Neeme Järvi. (AD: 1991). Chandos/Koch CD 9096

  18. Unresolved mourning, supernatural beliefs and dissociation: a mediation analysis.

    Science.gov (United States)

    Thomson, Paula; Jaque, S Victoria

    2014-01-01

    Unresolved mourning is marked by disorganized behavior and states of mind. In this study, we speculated that pathological dissociation would mediate the effects of unresolved mourning on supernatural beliefs. This hypothesis was determined based on findings that indicate an association between higher levels of dissociation, stronger beliefs in the supernatural and unresolved mourning. We examined two groups of participants, one classified as non-unresolved (non-U) (n = 56) and the other as unresolved (n = 26) (U) with respect to past loss/trauma as measured by the Adult Attachment Interview (AAI). Two self-report instruments were administered to measure supernatural beliefs and dissociation. As hypothesized, the multivariate analysis of variance indicated mean differences between the two groups. The unresolved group had greater belief in the supernatural and more pathological dissociative processes. The mediation analysis demonstrated that pathological dissociation fully mediated the effects of unresolved mourning on supernatural beliefs.

  19. G SUIT FOR EDUCATION AS AN ENVIRONMENT FOR STUDENTS OF EDUCATIONAL PRACTICES

    Directory of Open Access Journals (Sweden)

    Olena Glazunova

    2017-04-01

    Full Text Available Materials article analyzes the opportunities and benefits of using cloud services G Suite (Google Apps during the practical training of students. In the course of the study, an e-environment based on G Suit for Education was developed and its use for effective organization of information technology practice training. A model of e-learning environment for organizing group project work in Google Classroom-based training has been built. The design methodology is grounded as one of the most effective for the organization of educational practice in information technologies. The stages of realization of the project task during the educational practice, as well as the tools, the achieved competence, features of the activity of teachers and students at each stage are researched. Examples of tasks, resources and services that were used to achieve project results are given.The implementation of individual project implementation phases in the Google Classroom-based electronic environment has been demonstrated, in particular, project planning, adding new services in the electronic environment, collaborative work with documents, portfolio elements, student reflection. The results of the survey of students on the organization of educational practice using the method of projects and the e-environment based on the use of cloud services G Suite (Google Apps are analyzed.

  20. Comparison of efficacy, safety, and predictability of laser in situ keratomileusis using two laser suites

    Directory of Open Access Journals (Sweden)

    Meidani A

    2016-08-01

    Full Text Available Alexandra Meidani,1–3 Chara Tzavara3 1Hypervision Laser Centre, 2Eye Day Clinic, 3Department of Hygiene, University of Athens Medical School, Centre for Health Services Research, Epidemiology and Medical Statistics, Athens, Greece Purpose: The main aim of this study was to compare the efficacy, safety, and predictability of femtosecond laser-assisted in situ keratomileusis performed by two different laser suites in the treatment of myopia for up to 6 months.Methods: In this two-site retrospective nonrandomized study, myopic eyes that underwent laser-assisted in situ keratomileusis using IntraLase FS 60 kHz formed group 1 and those using WaveLight FS200 femtosecond laser system formed group 2. Ablation was performed with Visx Star S4 IR and WaveLight EX500 Excimer lasers, respectively, in groups 1 and 2. Both groups were well matched for age, sex, and mean level of preoperative refractive spherical equivalent (MRSE. Uncorrected distance visual acuity, corrected distance visual acuity, and MRSE were evaluated preoperatively and at 1 week, 1 month, and 6 months after treatment.Results: Fifty-six eyes of 28 patients were included in the study. At 6-month follow-up postop, 78.6% of eyes in group 1 and 92.8% of eyes in group 2 achieved an uncorrected distance visual acuity of 20/20 or better (P=0.252. 35.7% and 50% in group 1 and group 2, respectively, gained one line (P=0.179. No eye lost lines of corrected distance visual acuity. Twenty-five eyes in group 1 (92.7% and 27 eyes in group 2 (96.3% had MRSE within ±0.5 D in the 6-month follow-up (P>0.999. The mean efficacy index at 6 months was similar in group 1 and group 2 (mean 1.10±0.12 [standard deviation] vs 1.10±0.1 (P=0.799. The mean safety index was similar in group 1 and group 2 (mean 1.10±0.10 [standard deviation] vs 1.10±0.09 (P=0.407.Conclusion: The outcomes were excellent between the two laser suites. There were no significant differences at 6-month follow-up postop between the two

  1. On characters of finite groups

    CERN Document Server

    Broué, Michel

    2017-01-01

    This book explores the classical and beautiful character theory of finite groups. It does it by using some rudiments of the language of categories. Originally emerging from two courses offered at Peking University (PKU), primarily for third-year students, it is now better suited for graduate courses, and provides broader coverage than books that focus almost exclusively on groups. The book presents the basic tools, notions and theorems of character theory (including a new treatment of the control of fusion and isometries), and introduces readers to the categorical language at several levels. It includes and proves the major results on characteristic zero representations without any assumptions about the base field. The book includes a dedicated chapter on graded representations and applications of polynomial invariants of finite groups, and its closing chapter addresses the more recent notion of the Drinfeld double of a finite group and the corresponding representation of GL_2(Z).

  2. Metabolic and Subjective Results Review of the Integrated Suit Test Series

    Science.gov (United States)

    Norcross, J.R.; Stroud, L.C.; Klein, J.; Desantis, L.; Gernhardt, M.L.

    2009-01-01

    Crewmembers will perform a variety of exploration and construction activities on the lunar surface. These activities will be performed while inside an extravehicular activity (EVA) spacesuit. In most cases, human performance is compromised while inside an EVA suit as compared to a crewmember s unsuited performance baseline. Subjects completed different EVA type tasks, ranging from ambulation to geology and construction activities, in different lunar analog environments including overhead suspension, underwater and 1-g lunar-like terrain, in both suited and unsuited conditions. In the suited condition, the Mark III (MKIII) EVA technology demonstrator suit was used and suit pressure and suit weight were parameters tested. In the unsuited conditions, weight, mass, center of gravity (CG), terrain type and navigation were the parameters. To the extent possible, one parameter was varied while all others were held constant. Tests were not fully crossed, but rather one parameter was varied while all others were left in the most nominal setting. Oxygen consumption (VO2), modified Cooper-Harper (CH) ratings of operator compensation and ratings of perceived exertion (RPE) were measured for each trial. For each variable, a lower value correlates to more efficient task performance. Due to a low sample size, statistical significance was not attainable. Initial findings indicate that suit weight, CG and the operational environment can have a large impact on human performance during EVA. Systematic, prospective testing series such as those performed to date will enable a better understanding of the crucial interactions of the human and the EVA suit system and their environment. However, work remains to be done to confirm these findings. These data have been collected using only unsuited subjects and one EVA suit prototype that is known to fit poorly on a large demographic of the astronaut population. Key findings need to be retested using an EVA suit prototype better suited to a

  3. Does the medium matter? The interaction of task type and technology on group performance and member reactions.

    Science.gov (United States)

    Straus, S G; McGrath, J E

    1994-02-01

    The authors investigated the hypothesis that as group tasks pose greater requirements for member interdependence, communication media that transmit more social context cues will foster group performance and satisfaction. Seventy-two 3-person groups of undergraduate students worked in either computer-mediated or face-to-face meetings on 3 tasks with increasing levels of interdependence: an idea-generation task, an intellective task, and a judgment task. Results showed few differences between computer-mediated and face-to-face groups in the quality of the work completed but large differences in productivity favoring face-to-face groups. Analysis of productivity and of members' reactions supported the predicted interaction of tasks and media, with greater discrepancies between media conditions for tasks requiring higher levels of coordination. Results are discussed in terms of the implications of using computer-mediated communications systems for group work.

  4. Instrumented Suit Hard Upper Torso (HUT) for Ergonomic Assessment

    Data.gov (United States)

    National Aeronautics and Space Administration — It is well known that the EVA suit (EMU) has the potential to cause crew injury and decreased performance. Engineering data on the suit interaction of the human...

  5. BDNF mediates improvements in executive function following a 1-year exercise intervention

    Directory of Open Access Journals (Sweden)

    Regina Lynn Leckie

    2014-12-01

    Full Text Available Executive function declines with age, but engaging in aerobic exercise may attenuate decline. One mechanism by which aerobic exercise may preserve executive function is through the up-regulation of brain-derived neurotropic factor (BDNF, which also declines with age. The present study examined BDNF as a mediator of the effects of a 1-year walking intervention on executive function in 90 older adults (mean age = 66.82. Participants were randomized to a stretching and toning control group or a moderate intensity walking intervention group. BDNF serum levels and performance on a task-switching paradigm were collected at baseline and follow-up. We found that age moderated the effect of intervention group on changes in BDNF levels, with those in the highest age quartile showing the greatest increase in BDNF after 1-year of moderate intensity walking exercise (p = .036. The mediation analyses revealed that BDNF mediated the effect of the intervention on task-switch accuracy, but did so as a function of age, such that exercise-induced changes in BDNF mediated the effect of exercise on task-switch performance only for individuals over the age of 71. These results demonstrate that both age and BDNF serum levels are important factors to consider when investigating the mechanisms by which exercise interventions influence cognitive outcomes, particularly in elderly populations.

  6. Ultraviolet Testing of Space Suit Materials for Mars

    Science.gov (United States)

    Larson, Kristine; Fries, Marc

    2017-01-01

    Human missions to Mars may require radical changes in the approach to extra-vehicular (EVA) suit design. A major challenge is the balance of building a suit robust enough to complete multiple EVAs under intense ultraviolet (UV) light exposure without losing mechanical strength or compromising the suit's mobility. To study how the materials degrade on Mars in-situ, the Jet Propulsion Laboratory (JPL) invited the Advanced Space Suit team at NASA's Johnson Space Center (JSC) to place space suit materials on the Scanning Habitable Environments with Raman & Luminescence for Organics and Chemicals (SHERLOC) instrument's calibration target of the Mars 2020 rover. In order to select materials for the rover and understand the effects from Mars equivalent UV exposure, JSC conducted ground testing on both current and new space suit materials when exposed to 2500 hours of Mars mission equivalent UV. To complete this testing, JSC partnered with NASA's Marshall Space Flight Center to utilize their UV vacuum chambers. Materials tested were Orthofabric, polycarbonate, Teflon, Dacron, Vectran, spectra, bladder, nGimat coated Teflon, and nGimat coated Orthofabric. All samples were measured for mass, tensile strength, and chemical composition before and after radiation. Mass loss was insignificant (less than 0.5%) among the materials. Most materials loss tensile strength after radiation and became more brittle with a loss of elongation. Changes in chemical composition were seen in all radiated materials through Spectral Analysis. Results from this testing helped select the materials that will fly on the Mars 2020 rover. In addition, JSC can use this data to create a correlation to the chemical changes after radiation-which is what the rover will send back while on Mars-to the mechanical changes, such as tensile strength.

  7. High circulating osteoprotegerin levels are associated with non-zero blood groups.

    Science.gov (United States)

    Nagy, Elod Erno; Varga-Fekete, Timea; Puskas, Attila; Kelemen, Piroska; Brassai, Zoltan; Szekeres-Csiki, Katalin; Gombos, Timea; Csanyi, Maria Csilla; Harsfalvi, Jolan

    2016-05-26

    Osteoprotegerin (OPG) and von Willebrand factor (VWF) form complex within endothelial cells and following secretion. The nature of blood group antigens strongly influences the levels of circulating VWF, but there is no available data concerning its ascendancy on OPG levels. We aimed to assess the relationship of AB0 blood groups with OPG, VWF levels (VWF: Ag) and collagen binding activity (VWF: CB) in peripheral arterial disease (PAD) patients. Functional and laboratory parameters of 105 PAD patients and 109 controls were examined. Results of OPG, VWF: Ag, VWF: CB (ELISA-s) were analysed by comparative statistics, together with clinical data. OPG levels were higher in patients than in controls (4.64 ng/mL vs. 3.68 ng/mL, p blood groups compared to 0-groups both in patients and controls (4.95 ng/mL vs. 3.90 ng/mL, p = 0.012 and 4.09 ng/mL vs. 3.40 ng/mL, p = 0.002). OPG levels are associated to blood group phenotypes and higher in non-0 individuals. Increased OPG levels in PAD characterize disease severity. The significant correlation between OPG and VWF:CB might have functional importance in an atherothrombosis-prone biological environment.

  8. The Tomato U-Box Type E3 Ligase PUB13 Acts With Group III Ubiquitin E2 Enzymes to Modulate FLS2-Mediated Immune Signaling

    Directory of Open Access Journals (Sweden)

    Bangjun Zhou

    2018-05-01

    Full Text Available In Arabidopsis and rice, the ubiquitin ligase PUB13-mediated protein degradation plays a significant role in plant pattern-triggered immunity (PTI and flowering time control. The Arabidopsis PUB13 has been shown to attenuate the pattern recognition receptor FLS2-mediated immune signaling by ubiquitinating FLS2 and consequently promoting its degradation by the 26S proteasome. Nevertheless, the cognate ubiquitin-conjugating enzymes (E2 with which PUB13 acts to modulate FLS2-mediated PTI are unknown. To address this question, we investigate here the tomato (Solanum lycopersicum homolog of PUB13, SlPUB13 by utilizing the recently characterized complete set of tomato E2s. Of the 13 groups of tomato E2s, only members in group III are found to interact and act with SlPUB13. Knocking-down of the group III E2 genes enhances callose deposition and induction of the RbohB gene in the immunity-associated, early oxidative burst after flg22 treatment. The group III E2s are also found to work with SlPUB13 to ubiquitinate FLS2 in vitro and are required for PUB13-mediated degradation of FLS2 in vivo upon flg22 treatment, suggesting an essential role for group III E2s in the modulation of FLS2-mediated immune signaling by PUB13. Additionally, another immunity-associated E3, NtCMPG1 is shown to also work specifically with members of group III E2 in the in vitro ubiquitination assay, which implies the group III E2 enzymes may cooperate with many E3 ligases to regulate different aspects of PTI. Taken together, these data corroborate the notion that group III E2 enzymes play an important role in PTI and build a foundation for further functional and mechanistic characterization of tomato PUB13.

  9. Chemically mediated group formation in soil-dwelling larvae and pupae of the beetle Trypoxylus dichotomus

    Science.gov (United States)

    Kojima, Wataru; Ishikawa, Yukio; Takanashi, Takuma

    2014-09-01

    Many insects form groups through interactions among individuals, and these are often mediated by chemical, acoustic, or visual cues and signals. In spite of the diversity of soil-dwelling insects, their aggregation behaviour has not been examined as extensively as that of aboveground species. We investigated the aggregation mechanisms of larvae of the Japanese rhinoceros beetle Trypoxylus dichotomus, which live in groups in humus soil. In two-choice laboratory tests, 2nd- and 3rd-instar larvae gathered at conspecific larvae irrespective of the kinship. The ablation of maxillae, which bear chemosensilla, abolished aggregation behaviour. Intact larvae also exhibited aggregation behaviour towards a larval homogenate. These results suggest that larval aggregation is mediated by chemical cues. We also demonstrated that the mature larvae of T. dichotomus built their pupal cells close to a mesh bag containing a conspecific pupal cell, which indicated that larvae utilize chemical cues emanating from these cells to select the pupation site. Thus, the larvae of T. dichotomus may use chemical cues from the conspecifics in two different contexts, i.e. larval aggregation and pupation site selection. Using conspecific cues, larvae may be able to choose suitable locations for foraging or building pupal cells. The results of the present study highlight the importance of chemical information in belowground ecology.

  10. Exogenous estrogen as mediator of racial differences in bioactive insulin-like growth factor-I levels among postmenopausal women.

    Science.gov (United States)

    Jung, Su Yon; Vitolins, Mara Z; Paskett, Electra D; Chang, Shine

    2015-04-01

    The role of exogenous estrogen use in racial differences in insulin-like growth factor-I (IGF-I) levels which affect cancer risk is unclear. We investigated whether the relationship between race and circulating bioactive IGF-I proteins was mediated by exogenous estrogen and the extent to which exogenous estrogen influenced the race-IGF-I relationship in postmenopausal women. This cross-sectional study included 636 white and 133 African American postmenopausal women enrolled in an ancillary study of the Women's Health Initiative Observational Study. To assess exogenous estrogen use (nonusers [n = 262] vs users [n = 507]) as a mediator of the race-IGF-I relationship, we used the Baron-Kenny method and an estimation of the proportional change in the odd ratios for IGF-I levels on race plus a bootstrapping test for the significance of the mediation effect. Compared with white women, African American women were more likely to have high IGF-I levels and less likely to use exogenous estrogen. After accounting for race, estrogen nonusers had higher IGF-I levels than estrogen users did. Among oral contraceptive ever users, exogenous estrogen had a strong mediation effect (67%; p = .018) in the race-IGF-I relationship. In the women with a history of hypertension, exogenous estrogen explained racial differences in IGF-I levels to a modest degree (23%; p = .029). Exogenous estrogen use has a potentially important role in disparities in IGF-I bioactivity between postmenopausal African American and white women. A history of oral contraceptive use and hypertension may be part of the interconnected hormonal pathways related to racial differences in IGF-I levels. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Key Informant Models for Measuring Group-Level Variables in Small Groups: Application to Plural Subject Theory

    Science.gov (United States)

    Algesheimer, René; Bagozzi, Richard P.; Dholakia, Utpal M.

    2018-01-01

    We offer a new conceptualization and measurement models for constructs at the group-level of analysis in small group research. The conceptualization starts with classical notions of group behavior proposed by Tönnies, Simmel, and Weber and then draws upon plural subject theory by philosophers Gilbert and Tuomela to frame a new perspective…

  12. Comparison of the Effects of Aerobic Exercise on Pulmonary Function and Levels of Inflammatory Mediators in Men With Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Hossein Saki

    2017-06-01

    Full Text Available Introduction: Insufficient pulmonary function is a complication of type 2 diabetes coordinating with poor blood sugar management and promoting an inflammatory condition. Our objective was to assess the effects of consistent aerobic exercises on pulmonary function and levels of some inflammatory cytokines in males with type 2 diabetes. Methods: In the present semi-experimental study, 20 men with type 2 diabetes were selected using purposive sampling method. The recruited patients were randomly assigned into one of the aerobic exercise or control groups. The exercises continued for 8 weeks, 3 sessions per week, and each session consisted 45-60 minutes of aerobic exercise with intensity of 50%-70% heart rate reserve (HRR. Spirometry and hematologic parameters were both measured at 48 hours prior and 72 hours subsequent to the intervention. Statistical analysis was performed using SPSS v. 22.0 statistical software. Independent and paired sample t test were used for inferential analysis with P≤0.05 regarded as statistically significant. Results: A significant reduction was observed in serum levels of fasting blood sugar (FBS, glycosylated hemoglobin (HbA1c, C-reactive protein (CRP, and interleukin 6 (IL-6 in aerobic exercise group (P<0.05. On the other hand, forced vital capacity (FVC, and forced expiratory volume (FEV1 levels showed a significant elevation in the experimental group relative to the control. Conclusion: Considering our findings, it seems that aerobic exercise can improve pulmonary function in type 2 diabetes patients. This may be in some levels mediated by stabilizing blood glucose levels and subsiding systemic inflammatory condition in these patients.

  13. Interaction of Space Suits with Windblown Soil: Preliminary Mars Wind Tunnel Results

    Science.gov (United States)

    Marshall, J.; Bratton, C.; Kosmo, J.; Trevino, R.

    1999-09-01

    Experiments in the Mars Wind Tunnel at NASA Ames Research Center show that under Mars conditions, spacesuit materials are highly susceptible to dust contamination when exposed to windblown soil. This effect was suspected from knowledge of the interaction of electrostatically adhesive dust with solid surfaces in general. However, it is important to evaluate the respective roles of materials, meteorological and radiation effects, and the character of the soil. The tunnel permits evaluation of dust contamination and sand abrasion of space suits by simulating both pressure and wind conditions on Mars. The long-term function of space suits on Mars will be primarily threatened by dust contamination. Lunar EVA activities caused heavy contamination of space suits, but the problem was never seriously manifest because of the brief utilization of the suits, and the suits were never reused. Electrostatically adhering dust grains have various detrimental effects: (1) penetration and subsequent wear of suit fabrics, (2) viewing obscuration through visors and scratching/pitting of visor surfaces, (3) penetration, wear, and subsequent seizing-up of mechanical suit joints, (4) changes in albedo and therefore of radiation properties of external heat-exchanger systems, (5) changes in electrical conductivity of suit surfaces which may affect tribocharging of suits and create spurious discharge effects detrimental to suit electronics/radio systems. Additional information is contained in the original.

  14. Inertial motion capture system for biomechanical analysis in pressure suits

    Science.gov (United States)

    Di Capua, Massimiliano

    A non-invasive system has been developed at the University of Maryland Space System Laboratory with the goal of providing a new capability for quantifying the motion of the human inside a space suit. Based on an array of six microprocessors and eighteen microelectromechanical (MEMS) inertial measurement units (IMUs), the Body Pose Measurement System (BPMS) allows the monitoring of the kinematics of the suit occupant in an unobtrusive, self-contained, lightweight and compact fashion, without requiring any external equipment such as those necessary with modern optical motion capture systems. BPMS measures and stores the accelerations, angular rates and magnetic fields acting upon each IMU, which are mounted on the head, torso, and each segment of each limb. In order to convert the raw data into a more useful form, such as a set of body segment angles quantifying pose and motion, a series of geometrical models and a non-linear complimentary filter were implemented. The first portion of this works focuses on assessing system performance, which was measured by comparing the BPMS filtered data against rigid body angles measured through an external VICON optical motion capture system. This type of system is the industry standard, and is used here for independent measurement of body pose angles. By comparing the two sets of data, performance metrics such as BPMS system operational conditions, accuracy, and drift were evaluated and correlated against VICON data. After the system and models were verified and their capabilities and limitations assessed, a series of pressure suit evaluations were conducted. Three different pressure suits were used to identify the relationship between usable range of motion and internal suit pressure. In addition to addressing range of motion, a series of exploration tasks were also performed, recorded, and analysed in order to identify different motion patterns and trajectories as suit pressure is increased and overall suit mobility is reduced

  15. Item Response Theory at Subject- and Group-Level. Research Report 90-1.

    Science.gov (United States)

    Tobi, Hilde

    This paper reviews the literature about item response models for the subject level and aggregated level (group level). Group-level item response models (IRMs) are used in the United States in large-scale assessment programs such as the National Assessment of Educational Progress and the California Assessment Program. In the Netherlands, these…

  16. Modeling the Impact of Space Suit Components and Anthropometry on the Center of Mass of a Seated Crewmember

    Science.gov (United States)

    Blackledge, Christopher; Margerum, Sarah; Ferrer, Mike; Morency, Richard; Rajulu, Sudhakar

    2010-01-01

    The Crew Impact Attenuation System (CIAS) is the energy-absorbing strut concept that dampens Orion Crew Exploration Vehicle (CEV) landing loads to levels sustainable by the crew. Significant COM variations across suited crew configurations would amplify the inertial effects of the pallet and potentially create unacceptable crew loading during launch and landing. The objective of this study was to obtain data needed for dynamic simulation models by quantifying the effects of posture, suit components, and the expected range of anthropometry on the COM of a seated individual. Several elements are required for the COM calculation of a suited human in a seated position: anthropometry, body segment mass, suit component mass, suit component location relative to the body, and joint angles defining the seated posture. Three-dimensional (3D) human body models, suit mass data, and vector calculus were utilized to compute the COM positions for 12 boundary manikins in two different seated postures. The analysis focused on two objectives: (1) quantify how much the wholebody COM varied from the smallest to largest subject and (2) quantify the effects of the suit components on the overall COM in each seat configuration. The location of the anterior-posterior COM varied across all boundary manikins by about 7 cm, and the vertical COM varied by approximately 9 to 10 cm. The mediolateral COM varied by 1.2 cm from the midline sagittal plane for both seat configurations. The suit components caused an anterior shift of the total COM by approximately 2 cm and a shift to the right along the mediolateral axis of 0.4 cm for both seat configurations. When the seat configuration was in the standard posture the suited vertical COM shifted inferiorly by as much as 1 cm, whereas in the CEV posture the vertical COM had no appreciable change. These general differences were due to the high proportion of suit mass located in the boots and lower legs and their corresponding distance from the body COM

  17. White blood cell counts mediate the effects of physical activity on prostate-specific antigen levels.

    Science.gov (United States)

    Loprinzi, Paul D; Richart, Sarah M

    2014-09-01

    The purpose of this study was to examine whether white blood cell (WBC) level mediated the relationship between physical activity and prostate-specific antigen (PSA) levels. Data from the 2003-2006 National Health and Nutrition Examination Survey were used; 1,726 U.S. adult men (aged 40 years or older) provided complete data on the study variables. Participants wore an ActiGraph 7164 accelerometer for a 7-day period to measure their physical activity behavior, and PSA and WBC levels were obtained from a blood sample. After adjustments, results showed that moderate-to-vigorous physical activity (MVPA) was inversely associated with WBC count (b = - .03; 95% CI [ - 0.04, - 0.006; p = .01), and WBC count (b = .10; 95% CI [0.009, 0.18; p = .04) was positively associated with PSA. Both the Sobel (coef. = - .004, SE = .002; z = - 2.0; p = .03) and the Aroian (coef. = - .004, SE = .002; z = - 1.9; p = .03) tests demonstrated that WBC mediated the relationship between physical activity and PSA. Additionally, among 107 participants with prostate cancer, survivors engaging in more MVPA had lower levels of WBC (b = - .04; 95% CI [ - 0.09, - 0.0009; p = .04). Conclusion Physical activity may influence PSA levels through WBC modulation; however, future research is needed to determine the direction of causality. Additionally, prostate cancer survivors engaging in higher levels of MVPA had lower levels of WBC, underscoring the importance of promoting physical activity among prostate cancer survivors.

  18. A Secure Communication Suite for Underwater Acoustic Sensor Networks

    Directory of Open Access Journals (Sweden)

    Angelica Lo Duca

    2012-11-01

    Full Text Available In this paper we describe a security suite for Underwater Acoustic Sensor Networks comprising both fixed and mobile nodes. The security suite is composed of a secure routing protocol and a set of cryptographic primitives aimed at protecting the confidentiality and the integrity of underwater communication while taking into account the unique characteristics and constraints of the acoustic channel. By means of experiments and simulations based on real data, we show that the suite is suitable for an underwater networking environment as it introduces limited, and sometimes negligible, communication and power consumption overhead.

  19. AFRICAN-STYLE MEDIATION AND WESTERN-STYLE DIVORCE AND FAMILY MEDIATION: REFLECTIONS FOR THE SOUTH AFRICAN CONTEXT

    Directory of Open Access Journals (Sweden)

    AE Boniface

    2012-12-01

    Full Text Available Both Western-styled mediation and African-styled mediation are practised in South Africa. Each of these models is applied in specific social contexts. In this article a brief explanation of what is meant by the term divorce and family mediation is provided. Thereafter the principles and processes of both Western-styled divorce and family mediation and African-styled group mediation are explored. Attention is given to the roles of mediators in both of these models as well as the ubuntu-styled values found in African group mediation. In Africa, there is a tradition of family neighbourhood negotiation facilitated by elders and an attitude of togetherness in the spirit of humanhood. Both of these show a commitment to the community concerned and a comprehensive view of life. In Africa conflicts are viewed as non-isolated events and are viewed in their social contexts. Not only are consequences for the disputing parties taken into account but also consequences for others in their families. These methods can be found in present-day methods, which are either used independently of imported Western structures or used alternatively to such structures. In this article the concept of mediation circles, as currently found in Western-styled mediation are also covered. Additionally, the provisions of the Children’s Act 38 of 2005 referring to mediation as well as the provisions of the Child Justice Act 75 of 2008 and family group conferencing in the realm of restorative justice in South Africa are critiqued. It is suggested that divorce and family mediation can learn from the principles of restorative justice applied during family group conferencing as well as from African-styled group mediation.

  20. HPC Benchmark Suite NMx, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Intelligent Automation Inc., (IAI) and University of Central Florida (UCF) propose to develop a comprehensive numerical test suite for benchmarking current and...

  1. Oracle E-Business Suite Financials R12 A Functionality Guide

    CERN Document Server

    Iyer, Mohan

    2012-01-01

    This is a step-by-step functional guide to get you started easily with Oracle EBS Financials. If you are an Oracle E-Business Suite Financial consultant or an administrator looking to get a quick review on the capabilities of Oracle E-Business Suite and improve the use of the systems functionality, then this is the best guide for you. This book assumes that you have a fundamental knowledge of EBS Suite.

  2. Pheromone-modulated behavioral suites influence colony growth in the honey bee (Apis mellifera)

    Science.gov (United States)

    Pankiw, Tanya; Roman, Roman; Sagili, Ramesh R.; Zhu-Salzman, Keyan

    2004-12-01

    The success of a species depends on its ability to assess its environment and to decide accordingly which behaviors are most appropriate. Many animal species, from bacteria to mammals, are able to communicate using interspecies chemicals called pheromones. In addition to exerting physiological effects on individuals, for social species, pheromones communicate group social structure. Communication of social structure is important to social insects for the allocation of its working members into coordinated suites of behaviors. We tested effects of long-term treatment with brood pheromone on suites of honey bee brood rearing and foraging behaviors. Pheromone-treated colonies reared significantly greater brood areas and more adults than controls, while amounts of stored pollen and honey remained statistically similar. Brood pheromone increased the number of pollen foragers and the pollen load weights they returned. It appeared that the pheromone-induced increase in pollen intake was directly canalized into more brood rearing. A two-way pheromone priming effect was observed, such that some workers from the same age cohorts showed an increased and extended capacity to rear larvae, while others were recruited at significantly younger ages into pollen-specific foraging. Brood pheromone affected suites of nursing and foraging behaviors allocating worker and pollen resources associated with an important fitness trait, colony growth.

  3. Mercury levels in defined population groups

    International Nuclear Information System (INIS)

    Ingrao, G.; Belloni, P.; Santaroni, G.P.

    1995-01-01

    Hair samples from subjects living in the areas of Bagnara Calabra, Fiumicino and Ravenna, having a fish consumption above the national average, have been analyzed. A new location close to the Lagoon of Grado and Marano, located near the border with Slovenia, has been Selected because of the high natural levels of mercury in this lagoon due to the discharge of the Isonzo river, a tributary of which crosses the mercury rich area of Idria in Slovenia. During the last year, a group of pregnant women were selected in Rome, Bagnara Calabra, Ravenna and the area of the Lagoon of Grado and Marano. Samples of hair, pubic hair and placenta were collected from each of the subjects. A sample of the newborn hair was also collected whenever possible. The preliminary results indicate higher mercury levels in the subjects living in the area around the Lagoon of Grado and Marano. (author)

  4. Exploration Space Suit Architecture: Destination Environmental-Based Technology Development

    Science.gov (United States)

    Hill, Terry R.

    2010-01-01

    This paper picks up where EVA Space Suit Architecture: Low Earth Orbit Vs. Moon Vs. Mars (Hill, Johnson, IEEEAC paper #1209) left off in the development of a space suit architecture that is modular in design and interfaces and could be reconfigured to meet the mission or during any given mission depending on the tasks or destination. This paper will walk though the continued development of a space suit system architecture, and how it should evolve to meeting the future exploration EVA needs of the United States space program. In looking forward to future US space exploration and determining how the work performed to date in the CxP and how this would map to a future space suit architecture with maximum re-use of technology and functionality, a series of thought exercises and analysis have provided a strong indication that the CxP space suit architecture is well postured to provide a viable solution for future exploration missions. Through the destination environmental analysis that is presented in this paper, the modular architecture approach provides the lowest mass, lowest mission cost for the protection of the crew given any human mission outside of low Earth orbit. Some of the studies presented here provide a look and validation of the non-environmental design drivers that will become every-increasingly important the further away from Earth humans venture and the longer they are away. Additionally, the analysis demonstrates a logical clustering of design environments that allows a very focused approach to technology prioritization, development and design that will maximize the return on investment independent of any particular program and provide architecture and design solutions for space suit systems in time or ahead of being required for any particular manned flight program in the future. The new approach to space suit design and interface definition the discussion will show how the architecture is very adaptable to programmatic and funding changes with

  5. The ESA's Space Trajectory Analysis software suite

    Science.gov (United States)

    Ortega, Guillermo

    The European Space Agency (ESA) initiated in 2005 an internal activity to develop an open source software suite involving university science departments and research institutions all over the world. This project is called the "Space Trajectory Analysis" or STA. This article describes the birth of STA and its present configuration. One of the STA aims is to promote the exchange of technical ideas, and raise knowledge and competence in the areas of applied mathematics, space engineering, and informatics at University level. Conceived as a research and education tool to support the analysis phase of a space mission, STA is able to visualize a wide range of space trajectories. These include among others ascent, re-entry, descent and landing trajectories, orbits around planets and moons, interplanetary trajectories, rendezvous trajectories, etc. The article explains that STA project is an original idea of the Technical Directorate of ESA. It was born in August 2005 to provide a framework in astrodynamics research at University level. As research and education software applicable to Academia, a number of Universities support this development by joining ESA in leading the development. ESA and Universities partnership are expressed in the STA Steering Board. Together with ESA, each University has a chair in the board whose tasks are develop, control, promote, maintain, and expand the software suite. The article describes that STA provides calculations in the fields of spacecraft tracking, attitude analysis, coverage and visibility analysis, orbit determination, position and velocity of solar system bodies, etc. STA implements the concept of "space scenario" composed of Solar system bodies, spacecraft, ground stations, pads, etc. It is able to propagate the orbit of a spacecraft where orbital propagators are included. STA is able to compute communication links between objects of a scenario (coverage, line of sight), and to represent the trajectory computations and

  6. HPC Benchmark Suite NMx, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — In the phase II effort, Intelligent Automation Inc., (IAI) and University of Central Florida (UCF) propose to develop a comprehensive numerical test suite for...

  7. Cosmonaut Sergei Krikalev receives assistance from suit technician

    Science.gov (United States)

    1994-01-01

    Sergei Krikalev, alternative mission specialist for STS-63, gets help from Dawn Mays, a Boeing suit technician. The cosmonaut was about to participate in a training session at JSC's Weightless Environment Training Facility (WETF). Wearing the training version of the extravehicular mobility unit (EMU) space suit, weighted to allow neutral buoyancy in the 25 feet deep WETF pool, Krikalev minutes later was underwater simulating a contingency spacewalk, or extravehicular activity (EVA).

  8. The BTeV Software Tutorial Suite

    International Nuclear Information System (INIS)

    Kutschke, Robert K.

    2004-01-01

    The BTeV Collaboration is starting to develop its C++ based offline software suite, an integral part of which is a series of tutorials. These tutorials are targeted at a diverse audience, including new graduate students, experienced physicists with little or no C++ experience, those with just enough C++ to be dangerous, and experts who need only an overview of the available tools. The tutorials must both teach C++ in general and the BTeV specific tools in particular. Finally, they must teach physicists how to find and use the detailed documentation. This report will review the status of the BTeV experiment, give an overview of the plans for and the state of the software and will then describe the plans for the tutorial suite

  9. The antigravity suit in neurosurgery. Cardiovascular responses in seated neurosurgical patients.

    Science.gov (United States)

    Brodrick, P M; Ingram, G S

    1988-09-01

    The haemodynamic responses associated with inflation of the antigravity suit (G suit, aviation type) to 8.0 kPa were studied in a series of 40 patients who underwent neurosurgical operations in the sitting position. The study showed statistically significant increases in systolic arterial pressure (p less than 0.005) and mean central venous pressure (p less than 0.001) with inflation of the suit. The systolic arterial and mean central venous pressures remained significantly elevated immediately before deflation of the suit at the end of the operation (p less than 0.001 and p less than 0.005 respectively). The addition of 0.8-1.0 kPa positive end expiratory pressure during suit inflation was also investigated. A further increase in central venous pressure occurred but this did not achieve statistical significance.

  10. Characterization of the Radiation Shielding Properties of US and Russian EVA Suits

    International Nuclear Information System (INIS)

    Benton, E.R.; Benton, E.V.; Frank, A.L.

    2001-01-01

    Reported herein are results from the Eril Research, Inc. (ERI) participation in the NASA Johnson Space Center sponsored study characterizing the radiation shielding properties of the two types of space suit that astronauts are wearing during the EVA on-orbit assembly of the International Space Station (ISS). Measurements using passive detectors were carried out to assess the shielding properties of the USEMU Suit and the Russian Orlan-M suit during irradiations of the suits and a tissue equivalent phantom to monoenergetic proton and electron beams at the Loma Linda University Medical Center (LLUMC). During irradiations of 6 MeV electrons and 60 MeV protons, absorbed dose as a function of depth was measured using TLDs exposed behind swatches of the two suit materials and inside the two EVA helmets. Considerable reduction in electron dose was measured behind all suit materials in exposures to 6MeV electrons. Slowing of the proton beam in the suit materials led to an increase in dose measured in exposures to 60 MeV protons. During 232 MeV proton irradiations, measurements were made with TLDs and CR-39 PNTDs at five organ locations inside a tissue equivalent phantom, exposed both with and without the two EVA suits. The EVA helmets produce a 13 to 27 percent reduction in total dose and a 0 to 25 percent reduction in dose equivalent when compared to measurements made in the phantom head alone. Differences in dose and dose equivalent between the suit and non-suit irradiations for the lower portions of the two EVA suits tended to be smaller. Proton-induced target fragmentation was found to be a significant source of increased dose equivalent, especially within the two EVA helmets, and average quality factor inside the EMU and Orlan-M helmets was 2 to 14 percent greater than that measured in the bare phantom head

  11. Estimation of indirect effect when the mediator is a censored variable.

    Science.gov (United States)

    Wang, Jian; Shete, Sanjay

    2017-01-01

    A mediation model explores the direct and indirect effects of an initial variable ( X) on an outcome variable ( Y) by including a mediator ( M). In many realistic scenarios, investigators observe censored data instead of the complete data. Current research in mediation analysis for censored data focuses mainly on censored outcomes, but not censored mediators. In this study, we proposed a strategy based on the accelerated failure time model and a multiple imputation approach. We adapted a measure of the indirect effect for the mediation model with a censored mediator, which can assess the indirect effect at both the group and individual levels. Based on simulation, we established the bias in the estimations of different paths (i.e. the effects of X on M [ a], of M on Y [ b] and of X on Y given mediator M [ c']) and indirect effects when analyzing the data using the existing approaches, including a naïve approach implemented in software such as Mplus, complete-case analysis, and the Tobit mediation model. We conducted simulation studies to investigate the performance of the proposed strategy compared to that of the existing approaches. The proposed strategy accurately estimates the coefficients of different paths, indirect effects and percentages of the total effects mediated. We applied these mediation approaches to the study of SNPs, age at menopause and fasting glucose levels. Our results indicate that there is no indirect effect of association between SNPs and fasting glucose level that is mediated through the age at menopause.

  12. Depression, anxiety and loss of resilience after multiple traumas: an illustration of a mediated moderation model of sensitization in a group of children who survived the Nazi Holocaust.

    Science.gov (United States)

    Fossion, Pierre; Leys, Christophe; Kempenaers, Chantal; Braun, Stephanie; Verbanck, Paul; Linkowski, Paul

    2013-12-01

    Depressive and anxiety disorders (DAD) have become a major public health problem. Multiple trauma is known to increase the risk of DAD through a sensitization mechanism. We investigate the hypothesis that resilience is a mediator of this mechanism. Former Hidden Children (FHC), the Jewish youths who spent World War II in various hideaway shelters across Nazi-occupied Europe, were compared with a control group. In each group, we measured the presence of multiple traumas, the resilience with the Resilience Scale for Adults, which has a six factors solution, and the DAD with the Hopkins Symptoms Checklist. We test a mediated moderation model with childhood trauma as the predictor; Later trauma as the moderator; Resilience as the mediator; and DAD as the outcome variable. Results are consistent with a sensitization model of DAD mediated by resilience: confrontation with a primary trauma during childhood followed by secondary trauma(s) after childhood damages resilience, which, in turn, results in higher level of DAD. We are unable to differentiate if the sensitization process is a consequence of the nature of the trauma endured by FHC (long-standing exposure to extreme external events) or a consequence of the fact that this first trauma occurred during childhood. Resilience construct is multi-factorial and a limited damaging of some of the factors is sufficient to lead to DAD even if other factors remain unaltered. Resilience can be altered by multiple traumas and, therefore, needs to be bolstered in therapy sessions. Copyright © 2013. Published by Elsevier B.V.

  13. Single-Participant Assessment of Treatment Mediators: Strategy Description and Examples from a Behavioral Activation Intervention for Depressed Adolescents

    Science.gov (United States)

    Gaynor, Scott T.; Harris, Amanda

    2008-01-01

    Determining the means by which effective psychotherapy works is critical. A generally recommended strategy for identifying the potential causal variables is to conduct group-level statistical tests of treatment mediators. Herein the case is made for also assessing mediators of treatment outcome at the level of the individual participant.…

  14. Power Analysis for Cross Level Mediation in CRTs

    Science.gov (United States)

    Kelcey, Ben

    2014-01-01

    A common design in education research for interventions operating at a group or cluster level is a cluster randomized trial (CRT) (Bloom, 2005). In CRTs, intact clusters (e.g., schools) are assigned to treatment conditions rather than individuals (e.g., students) and are frequently an effective way to study interventions because they permit…

  15. Extending the GI Brokering Suite to Support New Interoperability Specifications

    Science.gov (United States)

    Boldrini, E.; Papeschi, F.; Santoro, M.; Nativi, S.

    2014-12-01

    The GI brokering suite provides the discovery, access, and semantic Brokers (i.e. GI-cat, GI-axe, GI-sem) that empower a Brokering framework for multi-disciplinary and multi-organizational interoperability. GI suite has been successfully deployed in the framework of several programmes and initiatives, such as European Union funded projects, NSF BCube, and the intergovernmental coordinated effort Global Earth Observation System of Systems (GEOSS). Each GI suite Broker facilitates interoperability for a particular functionality (i.e. discovery, access, semantic extension) among a set of brokered resources published by autonomous providers (e.g. data repositories, web services, semantic assets) and a set of heterogeneous consumers (e.g. client applications, portals, apps). A wide set of data models, encoding formats, and service protocols are already supported by the GI suite, such as the ones defined by international standardizing organizations like OGC and ISO (e.g. WxS, CSW, SWE, GML, netCDF) and by Community specifications (e.g. THREDDS, OpenSearch, OPeNDAP, ESRI APIs). Using GI suite, resources published by a particular Community or organization through their specific technology (e.g. OPeNDAP/netCDF) can be transparently discovered, accessed, and used by different Communities utilizing their preferred tools (e.g. a GIS visualizing WMS layers). Since Information Technology is a moving target, new standards and technologies continuously emerge and are adopted in the Earth Science context too. Therefore, GI Brokering suite was conceived to be flexible and accommodate new interoperability protocols and data models. For example, GI suite has recently added support to well-used specifications, introduced to implement Linked data, Semantic Web and precise community needs. Amongst the others, they included: DCAT: a RDF vocabulary designed to facilitate interoperability between Web data catalogs. CKAN: a data management system for data distribution, particularly used by

  16. ANALYSIS OF DESIGN ELEMENTS IN SKI SUITS

    Directory of Open Access Journals (Sweden)

    Birsen Çileroğlu

    2014-06-01

    Full Text Available Popularity of Ski Sport in 19th century necessitated a new perspective on protective skiing clothing ag ainst the mountain climates and excessive cold. Winter clothing were the basis of ski attire during this period. By the beginning of 20th century lining cloth were used to minimize the wind effect. The difference between the men and women’s ski attire of the time consisted of a knee - length skirts worn over the golf trousers. Subsequent to the First World War, skiing suit models were influenced by the period uniforms and the producers reflected the fashion trends to the ski clothing. In conformance with th e prevailing trends, ski trousers were designed and produced for the women thus leading to reduction in gender differences. Increases in the ski tourism and holding of the first winter olympics in 1924 resulted in variations in ski attires, development of design characteristics, growth in user numbers, and enlargement of production capacities. Designers emphasized in their collections combined presence of elegance and practicality in the skiing attire. In 1930s, the ski suits influenced by pilots’ uniforms included characteristics permitting freedom of motion, and the design elements exhibited changes in terms of style, material and aerodynamics. In time, the ski attires showed varying design features distinguishing professionals from the amateurs. While protective functionality was primary consideration for the amateurs, for professionals the aerodynamic design was also a leading factor. Eventually, the increased differences in design characteristics were exhibited in ski suit collections, World reknown brands were formed, production and sales volumes showed significant rise. During 20th century the ski suits influenced by fashion trends to acquire unique styles reached a position of dominance to impact current fashion trends, and apart from sports attir es they became a style determinant in the clothing of cold climates. Ski suits

  17. Strauss: Der Rosenkavalier - Suite / Michael Kennedy

    Index Scriptorium Estoniae

    Kennedy, Michael

    1990-01-01

    Uuest heliplaadist "Strauss: Der Rosenkavalier - Suite, Salome-Dance of the seven veils, Capriccio-Prelude, Intermezzo, Morgen Mittag um elf! Felicity Lott, Scottish National Orchestra, Neeme Järvi" Chandos ABRD 1397. ABTD 1397. CHAN 8758

  18. Effect of Traditional Chinese Medicine on Inflammatory Mediators in Pediatric Asthma

    Directory of Open Access Journals (Sweden)

    Hui Du

    2016-01-01

    Full Text Available Objective. To observe the effects of empirical prescriptions of traditional Chinese medicine (TCM on inflammatory mediators in pediatric asthma and to explore the underlying molecular mechanism in the treatment of asthma. Methods. A total of 182 children with asthma were randomly placed into either the TCM group (n=97 or the salbutamol and montelukast (SM group (n=85. Patients in the TCM group were treated with a series of empirical prescriptions of TCM, while those in the SM group received salbutamol and montelukast. Both groups received their respective treatment for 12 weeks. There were 35 patients in TCM group and 34 patients in SM group providing venous blood. Real-time PCR was used to determine the mRNA expression levels of interleukin- (IL- 10, IL-17, matrix metalloproteinase-9 (MMP-9, and transforming growth factor β1 (TGF-β1 in peripheral blood mononuclear cells before and after treatment. Enzyme-linked immunosorbent assay was used to measure the levels of IL-10, IL-17, MMP-9, and TGF-β1 in peripheral blood before and after treatment. Results. The mRNA expression of TGF-β1 in the SM group was downregulated (P=0.00 after treatment. No significant differences were found between the TCM group and the SM group after treatment (P>0.05. In the TCM group, the levels of IL-10, IL-17, and MMP-9 significantly decreased after treatment (P=0.01, 0.04, and 0.03, resp.. In the SM group, IL-17, MMP-9, and TGF-β1 levels significantly decreased after treatment (P=0.00, 0.03, and 0.00, resp.. There was no significant difference between the two groups regarding the levels of IL-10, IL-17, TGF-β1, and MMP-9 (P>0.05. The difference of the level of IL-17 was negatively correlated with the change of C-ACT score in TCM group and SM group. Conclusion. TCM has a regulatory effect on the balance of some inflammatory mediators in pediatric asthma.

  19. Antibody-Mediated Rejection in a Blood Group A-Transgenic Mouse Model of ABO-Incompatible Heart Transplantation.

    Science.gov (United States)

    Motyka, Bruce; Fisicaro, Nella; Wang, Szu-I; Kratochvil, Annetta; Labonte, Katrina; Tao, Kesheng; Pearcey, Jean; Marshall, Thuraya; Mengel, Michael; Sis, Banu; Fan, Xiaohu; dʼApice, Anthony J F; Cowan, Peter J; West, Lori J

    2016-06-01

    ABO-incompatible (ABOi) organ transplantation is performed owing to unremitting donor shortages. Defining mechanisms of antibody-mediated rejection, accommodation, and tolerance of ABOi grafts is limited by lack of a suitable animal model. We report generation and characterization of a murine model to enable study of immunobiology in the setting of ABOi transplantation. Transgenesis of a construct containing human A1- and H-transferases under control of the ICAM-2 promoter was performed in C57BL/6 (B6) mice. A-transgenic (A-Tg) mice were assessed for A-antigen expression by histology and flow cytometry. B6 wild-type (WT) mice were sensitized with blood group A-human erythrocytes; others received passive anti-A monoclonal antibody and complement after heart transplant. Serum anti-A antibodies were assessed by hemagglutination. "A-into-O" transplantation (major histocompatibility complex syngeneic) was modeled by transplanting hearts from A-Tg mice into sensitized or nonsensitized WT mice. Antibody-mediated rejection was assessed by morphology/immunohistochemistry. A-Tg mice expressed A-antigen on vascular endothelium and other cells including erythrocytes. Antibody-mediated rejection was evident in 15/17 A-Tg grafts in sensitized WT recipients (median titer, 1:512), with 2 showing hyperacute rejection and rapid cessation of graft pulsation. Hyperacute rejection was observed in 8/8 A-Tg grafts after passive transfer of anti-A antibody and complement into nonsensitized recipients. Antibody-mediated rejection was not observed in A-Tg grafts transplanted into nonsensitized mice. A-Tg heart grafts transplanted into WT mice with abundant anti-A antibody manifests characteristic features of antibody-mediated rejection. These findings demonstrate an effective murine model to facilitate study of immunologic features of ABOi transplantation and to improve potential diagnostic and therapeutic strategies.

  20. Coupled Human-Space Suit Mobility Studies

    Data.gov (United States)

    National Aeronautics and Space Administration — Current EVA mobility studies only allow for comparisons of how the suit moves when actuated by a human and how the human moves when unsuited. There are now new...

  1. Discrete level schemes sublibrary. Progress report by Budapest group

    International Nuclear Information System (INIS)

    Oestor, J.; Belgya, T.; Molnar, G.L.

    1997-01-01

    An entirely new discrete levels file has been created by the Budapest group according to the recommended principles, using the Evaluated Nuclear Structure Data File, ENSDF as a source. The resulting library contains 96,834 levels and 105,423 gamma rays for 2,585 nuclei, with their characteristics such as energy, spin, parity, half-life as well gamma-ray energy and branching percentage

  2. Space Suit Performance: Methods for Changing the Quality of Quantitative Data

    Science.gov (United States)

    Cowley, Matthew; Benson, Elizabeth; Rajulu, Sudhakar

    2014-01-01

    NASA is currently designing a new space suit capable of working in deep space and on Mars. Designing a suit is very difficult and often requires trade-offs between performance, cost, mass, and system complexity. To verify that new suits will enable astronauts to perform to their maximum capacity, prototype suits must be built and tested with human subjects. However, engineers and flight surgeons often have difficulty understanding and applying traditional representations of human data without training. To overcome these challenges, NASA is developing modern simulation and analysis techniques that focus on 3D visualization. Early understanding of actual performance early on in the design cycle is extremely advantageous to increase performance capabilities, reduce the risk of injury, and reduce costs. The primary objective of this project was to test modern simulation and analysis techniques for evaluating the performance of a human operating in extra-vehicular space suits.

  3. An improved air-supplied plastic suit for protection against tritium

    International Nuclear Information System (INIS)

    Wiernicki, C.

    1987-01-01

    A newly developed Saran/CPE plastic suit material is described which offers significantly better protection against HTO penetration and permeation than the 12-mil PVC currently used at SRP and most other DOE and commercial sites where tritium and HTO are exposure hazards. Tritium breakthrough time is an important parameter when evaluating the applicability of protective clothing; previously published tritium permeation tests did not measure this parameter. Future studies should quantify steady-state permeation rate and breakthrough time to more fully evaluate potential tritium protective clothing. Saran/CPE has successfully been fabricated into a plastic suit because, in addition to its superior tritium resistance, it has all the characteristics required to construct a rugged, dependable, and comfortable suit. The use of the Saran/CPE suit at SRP reactor and tritium production facilities should be a major contribution to the site As Low As Reasonably Achievable program. Both Saran/CPE have demonstrated excellent resistance to a wide range of chemical contaminants; therefore, this suit material may have applications in the general chemical industry and hazardous waste site cleanup operations. 4 refs., 3 figs., 1 tab

  4. The pressurized suit and some considerations leading to the development of physiologically safe working conditions

    International Nuclear Information System (INIS)

    Evans, J.C.

    1980-01-01

    The safe working environment of men wearing pressurized suits in the U.K.A.E.A. is based on the results of two experimental programmes, the first investigated the respiratory hazards, the second the assessment and control of the level of thermal stress. Both are described. (author)

  5. Immunoconglutinin levels in normal and diseased population groups in Southern Africa

    Science.gov (United States)

    Watson, K. C.

    1971-01-01

    Immunoconglutinin (I-K) levels were measured in adult blood donors of European and African origin and in patients with the following diseases: acute typhoid fever, amoebic liver abscess, chronic liver disease and primary hepatoma. The lowest levels were found in the white donor group and the highest in those with chronic liver disease and those with primary hepatoma. African donors had levels higher than white donors which may relate to chronic infection and particularly chronic parasitic infestation. There was poor correlation between `O' and `H' antibodies and I-K levels in the typhoid group. In those with chronic liver disease there was some correlation between I-K levels and total γ-globulin and also with raised IgM and IgA levels but not with raised IgG. PMID:4103887

  6. Philosophies Applied in the Selection of Space Suit Joint Range of Motion Requirements

    Science.gov (United States)

    Aitchison, Lindsway; Ross, Amy; Matty, Jennifer

    2009-01-01

    Space suits are the most important tool for astronauts working in harsh space and planetary environments; suits keep crewmembers alive and allow them to perform exploration, construction, and scientific tasks on a routine basis over a period of several months. The efficiency with which the tasks are performed is largely dictated by the mobility features of the space suit. For previous space suit development programs, the mobility requirements were written as pure functional mobility requirements that did not separate joint ranges of motion from the joint torques. The Constellation Space Suit Element has the goal to make more quantitative mobility requirements that focused on the individual components of mobility to enable future suit designers to build and test systems more effectively. This paper details the test planning and selection process for the Constellation space suit pressure garment range of motion requirements.

  7. Volatile-mediated suppression of plant pathogens is related to soil properties and microbial community composition

    NARCIS (Netherlands)

    Van Agtmaal, M.; Straathof, A.L.; Termorshuizen, Aad J; Lievens, Bart; Hoffland, Ellis; De Boer, W.

    2018-01-01

    There is increasing evidence that the soil microbial community produces a suite of volatile organic compounds that suppress plant pathogens. However, it remains unknown which soil properties and management practices influence volatile-mediated pathogen suppression. The aim of this study was to

  8. Volatile-mediated suppression of plant pathogens is related to soil properties and microbial community composition

    NARCIS (Netherlands)

    Agtmaal, van Maaike; Straathof, Angela L.; Termorshuizen, Aad; Lievens, Bart; Hoffland, Ellis; Boer, de Wietse

    2018-01-01

    There is increasing evidence that the soil microbial community produces a suite of volatile organic compounds that suppress plant pathogens. However, it remains unknown which soil properties and management practices influence volatile-mediated pathogen suppression. The aim of this study was to

  9. Systemic inflammatory mediators in post-traumatic complex regional pain syndrome (CRPS I) - longitudinal investigations and differences to control groups.

    Science.gov (United States)

    Schinkel, Christian; Scherens, A; Köller, M; Roellecke, G; Muhr, G; Maier, C

    2009-03-17

    The Complex Regional Pain Syndrome I (CRPS I) is a disease that might affect an extremity after trauma or operation. The pathogenesis remains yet unclear. It has clinical signs of severe local inflammation as a result of an exaggerated inflammatory response but neurogenic dysregulation also contributes to it. Some studies investigated the role inflammatory mediators and cytokines; however, few longitudinal studies exist and control groups except healthy controls were not investigated yet. To get further insights into the role of systemic inflammatory mediators in CRPS I, we investigated a variety of pro-, anti-, or neuro-inflammatory mediators such as C-Reactive Protein (CRP), White Blood Cell Count (WBC), Interleukins 4, 6, 8, 10, 11, 12 (p70), Interferon gamma, Tumor-Necrosis-Factor alpha (TNF-a) and its soluble Receptors I/II, soluble Selectins (E,L,P), Substance-P (SP), and Calcitonin Gene-Related Peptide (CGRP) at different time points in venous blood from patients with acute (AC) and chronic (CC) CRPS I, patients with forearm fractures (FR), with neuralgia (NE), and from healthy volunteers (C). No significant changes for serum parameters investigated in CRPS compared to control groups were found except for CC/C (CGRP p = 0.007), FR/C (CGRP p = 0.048) and AC/CC (IL-12 p = 0.02; TNFRI/II p = 0.01; SP p = 0.049). High interindividual variations were observed. No intra- or interindividual correlation of parameters with clinical course (e.g. chronification) or outcome was detectable. Although clinically appearing as inflammation in acute stages, local rather than systemic inflammatory responses seem to be relevant in CRPS. Variable results from different studies might be explained by unpredictable intermittent release of mediators from local inflammatory processes into the blood combined with high interindividual variabilities. A clinically relevant difference to various control groups was not notable in this pilot study. Determination of systemic inflammatory

  10. Systemic inflammatory mediators in post-traumatic Complex Regional Pain Syndrome (CRPS I - longitudinal investigations and differences to control groups

    Directory of Open Access Journals (Sweden)

    Schinkel Ch

    2009-03-01

    Full Text Available Abstract Objectives The Complex Regional Pain Syndrome I (CRPS I is a disease that might affect an extremity after trauma or operation. The pathogenesis remains yet unclear. It has clinical signs of severe local inflammation as a result of an exaggerated inflammatory response but neurogenic dysregulation also contributes to it. Some studies investigated the role inflammatory mediators and cytokines; however, few longitudinal studies exist and control groups except healthy controls were not investigated yet. Methods To get further insights into the role of systemic inflammatory mediators in CRPS I, we investigated a variety of pro-, anti-, or neuro-inflammatory mediators such as C-Reactive Protein (CRP, White Blood Cell Count (WBC, Interleukins 4, 6, 8, 10, 11, 12 (p70, Interferon gamma, Tumor-Necrosis-Factor alpha (TNF-α and its soluble Receptors I/II, soluble Selectins (E, L, P, Substance-P (SP, and Calcitonin Gene-Related Peptide (CGRP at different time points in venous blood from patients with acute (AC and chronic (CC CRPS I, patients with forearm fractures (FR, with neuralgia (NE, and from healthy volunteers (C. Results No significant changes for serum parameters investigated in CRPS compared to control groups were found except for CC/C (CGRP p = 0.007, FR/C (CGRP p = 0.048 and AC/CC (IL-12 p = 0.02; TNFRI/II p = 0.01; SP p = 0.049. High interindividual variations were observed. No intra-or interindividual correlation of parameters with clinical course (e.g. chronification or outcome was detectable. Conclusion Although clinically appearing as inflammation in acute stages, local rather than systemic inflammatory responses seem to be relevant in CRPS. Variable results from different studies might be explained by unpredictable intermittent release of mediators from local inflammatory processes into the blood combined with high interindividual variabilities. A clinically relevant difference to various control groups was not notable in this

  11. Three Levels of Diversity: An Examination of the Complex Relationship Between Diversity, Group Cohesiveness, Sexual Harassment, Group Performance, and Time

    National Research Council Canada - National Science Library

    Whaley, Gary

    1998-01-01

    ...: surface, working, and deep level diversity. The author explains the nature of the relationship between the three levels of diversity and posits a general model of organizational behavior including diversity, group cohesiveness, group...

  12. Scalable group level probabilistic sparse factor analysis

    DEFF Research Database (Denmark)

    Hinrich, Jesper Løve; Nielsen, Søren Føns Vind; Riis, Nicolai Andre Brogaard

    2017-01-01

    Many data-driven approaches exist to extract neural representations of functional magnetic resonance imaging (fMRI) data, but most of them lack a proper probabilistic formulation. We propose a scalable group level probabilistic sparse factor analysis (psFA) allowing spatially sparse maps, component...... pruning using automatic relevance determination (ARD) and subject specific heteroscedastic spatial noise modeling. For task-based and resting state fMRI, we show that the sparsity constraint gives rise to components similar to those obtained by group independent component analysis. The noise modeling...... shows that noise is reduced in areas typically associated with activation by the experimental design. The psFA model identifies sparse components and the probabilistic setting provides a natural way to handle parameter uncertainties. The variational Bayesian framework easily extends to more complex...

  13. The Role of KREEP in the Production of Mg-Suite Magmas and Its Influence on the Extent of Mg-Suite Magmatism in the Lunar Crust

    Science.gov (United States)

    Elardo, S. M.; Shearer, C. K.; McCubbin, F. M.

    2017-01-01

    The lunar magnesian-suite, or Mg-suite, is a series of ancient plutonic rocks from the lunar crust. They have received a considerable amount of attention from lunar scientists since their discovery for three primary reasons: 1) their ages and geochemistry indicate they represent pristine magmatic samples that crystallized very soon after the formation of the Moon; 2) their ages often overlap with ages of the ferroan anorthosite (FAN) crust; and 3) planetary-scale processes are needed in formation models to account for their unique geochemical features. Taken as a whole, the Mg-suite samples, as magmatic cumulate rocks, approximate a fractional crystallization sequence in the low-pressure forsterite-anorthite-silica system, and thus these samples are generally thought to be derived from layered mafic intrusions which crystallized very slowly from magmas that intruded the anorthositic crust. However, no direct linkages have been established between different Mg-suite samples based either on field relationships or geochemistry.The model for the origin of the Mg-suite, which best fits the limited available data, is one where Mg-suite magmas form from melting of a hybrid cumulate package consisting of deep mantle dunite, crustal anorthosite, and KREEP (potassium-rare earth elements-phosphorus) at the base of the crust under the Procellarum KREEP Terrane (PKT). In this model, these three LMO (Lunar Magma Ocean) cumulate components are brought into close proximity by the cumulate overturn process. Deep mantle dunitic cumulates with an Mg number of approximately 90 rise to the base of the anorthositic crust due to their buoyancy relative to colder, more dense Fe- and Ti-rich cumulates. This hybridized source rock melts to form Mg-suite magmas, saturated in Mg-rich olivine and anorthitic plagioclase, that have a substantial KREEP component.

  14. Effectiveness comparison of partially executed t-way test suite based generated by existing strategies

    Science.gov (United States)

    Othman, Rozmie R.; Ahmad, Mohd Zamri Zahir; Ali, Mohd Shaiful Aziz Rashid; Zakaria, Hasneeza Liza; Rahman, Md. Mostafijur

    2015-05-01

    Consuming 40 to 50 percent of software development cost, software testing is one of the most resource consuming activities in software development lifecycle. To ensure an acceptable level of quality and reliability of a typical software product, it is desirable to test every possible combination of input data under various configurations. Due to combinatorial explosion problem, considering all exhaustive testing is practically impossible. Resource constraints, costing factors as well as strict time-to-market deadlines are amongst the main factors that inhibit such consideration. Earlier work suggests that sampling strategy (i.e. based on t-way parameter interaction or called as t-way testing) can be effective to reduce number of test cases without effecting the fault detection capability. However, for a very large system, even t-way strategy will produce a large test suite that need to be executed. In the end, only part of the planned test suite can be executed in order to meet the aforementioned constraints. Here, there is a need for test engineers to measure the effectiveness of partially executed test suite in order for them to assess the risk they have to take. Motivated by the abovementioned problem, this paper presents the effectiveness comparison of partially executed t-way test suite generated by existing strategies using tuples coverage method. Here, test engineers can predict the effectiveness of the testing process if only part of the original test cases is executed.

  15. Intragroup conflicts and efficiency of production group

    Directory of Open Access Journals (Sweden)

    Sidorenkov A.V.

    2017-08-01

    Full Text Available Analysis results of relationships of three levels of the conflict (interpersonal, microgroup and group on two types (the job and subject with indicators of subjectively perceived performance and social effectiveness of small groups and informal subgroups are provided. On selection of 42 work groups (N=334 employees it is established that performance efficiency of group according to the experts has inverse relation from all levels and types of the conflict, and by estimates of members of group — from two types of the microgroup conflict. The same type of effectiveness of informal subgroups on one indicator has inverse relation from the group conflict, and on another — from the interpersonal and microgroup conflict. Social effectiveness of group is connected with the interpersonal and group conflict, and informal subgroups are connected with the interpersonal and microgroup conflict. Levels and types of the conflict cause efficiency of group and subgroup not only separately, but also in a combination with each other. Six regression models, four of which display relationships at the same time of several levels and types of the conflict with performance effectiveness of group, and two — with social effectiveness of subgroup are revealed. Mediated and direct relationships of levels and types of the conflict with efficiency of group and subgroup are established.

  16. Group cohesion in sports teams of different professional level

    Directory of Open Access Journals (Sweden)

    Vazha M. Devishvili

    2017-12-01

    Full Text Available Background. Team sports are not only the most exciting sporting events. but also complex activities that make serious demands on players. The effectiveness of the team depends not only on the high level of gaming interaction. but also on the relationship between the players. The work is based on the material of sports teams and is devoted to the study of the phenomenon of group cohesion. As a basic model. the authors choose a 4-factor model that describes cohesion in sports teams. The paper also considered the phenomenon of the emergence of the aggregate subject in the process of joint activity. when the participants feel themselves as a whole and experience feelings of satisfaction and a surge of energy. Objective. The main objective of the work is to investigate the relationship between the level of team cohesion and subjective feelings of unity of its players. As additional variables in the study there is a sport (football and volleyball and team level (amateur and professional. To test the assumptions. two methods were used (the Sport Team Cohesion Questionnaire and the Subject Unity Index. which allow not only to determine the overall level of cohesion and unity. but also to reveal the structure of both phenomena. The study involved two men’s volleyball and two men’s football teams of different ages: 8-9 years (39 athletes; 12-14 years (24 athletes and 18-25 years (41 athletes. Design. For amateur groups represented by children’s and teenage sports teams. significant correlations between unity and unity were obtained (r = 0.618. p <0.01; r = 0.477. p <0.05. For professional teams. no significant correlations were found. Influence of the sport on cohesion is also different for amateur and professional teams. In the first case. the cohesion is higher for football players (U = 118. p <0.05. and in the second case for volleyball players (U = 124. p <0.05. Results. The findings indicate that the professional level of players affects group

  17. Corrections of the NIST Statistical Test Suite for Randomness

    OpenAIRE

    Kim, Song-Ju; Umeno, Ken; Hasegawa, Akio

    2004-01-01

    It is well known that the NIST statistical test suite was used for the evaluation of AES candidate algorithms. We have found that the test setting of Discrete Fourier Transform test and Lempel-Ziv test of this test suite are wrong. We give four corrections of mistakes in the test settings. This suggests that re-evaluation of the test results should be needed.

  18. Reliability performance testing of totally encapsulating chemical protective suits

    International Nuclear Information System (INIS)

    Johnson, J.S.; Swearengen, P.M.

    1991-01-01

    The need to assure a high degree of reliability for totally encapsulating chemical protective (TECP) suits has been recognized by Lawrence Livermore National Laboratory's (LLNL) Hazards Control Department for some time. The following four tests were proposed as necessary to provide complete evaluation of TECP suit performance: 1. Quantitative leak test (ASTM draft), 2. Worst-case chemical exposure test (conceptual), 3. Pressure leak-rate test (complete, ASTM F1057-87), and 4. Chemical leak-rate test (ASTM draft). This paper reports on these tests which should be applied to measuring TECP suit performance in two stages: design qualification tests and field use tests. Test 1, 2, and 3 are used as design qualification tests, and tests 3 and 4 are used as field use tests

  19. Suited versus unsuited analog astronaut performance using the Aouda.X space suit simulator: the DELTA experiment of MARS2013.

    Science.gov (United States)

    Soucek, Alexander; Ostkamp, Lutz; Paternesi, Roberta

    2015-04-01

    Space suit simulators are used for extravehicular activities (EVAs) during Mars analog missions. Flight planning and EVA productivity require accurate time estimates of activities to be performed with such simulators, such as experiment execution or traverse walking. We present a benchmarking methodology for the Aouda.X space suit simulator of the Austrian Space Forum. By measuring and comparing the times needed to perform a set of 10 test activities with and without Aouda.X, an average time delay was derived in the form of a multiplicative factor. This statistical value (a second-over-second time ratio) is 1.30 and shows that operations in Aouda.X take on average a third longer than the same operations without the suit. We also show that activities predominantly requiring fine motor skills are associated with larger time delays (between 1.17 and 1.59) than those requiring short-distance locomotion or short-term muscle strain (between 1.10 and 1.16). The results of the DELTA experiment performed during the MARS2013 field mission increase analog mission planning reliability and thus EVA efficiency and productivity when using Aouda.X.

  20. Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice.

    Science.gov (United States)

    De Vleesschauwer, David; Van Buyten, Evelien; Satoh, Kouji; Balidion, Johny; Mauleon, Ramil; Choi, Il-Ryong; Vera-Cruz, Casiana; Kikuchi, Shoshi; Höfte, Monica

    2012-04-01

    Brassinosteroids (BRs) are a unique class of plant steroid hormones that orchestrate myriad growth and developmental processes. Although BRs have long been known to protect plants from a suite of biotic and abiotic stresses, our understanding of the underlying molecular mechanisms is still rudimentary. Aiming to further decipher the molecular logic of BR-modulated immunity, we have examined the dynamics and impact of BRs during infection of rice (Oryza sativa) with the root oomycete Pythium graminicola. Challenging the prevailing view that BRs positively regulate plant innate immunity, we show that P. graminicola exploits BRs as virulence factors and hijacks the rice BR machinery to inflict disease. Moreover, we demonstrate that this immune-suppressive effect of BRs is due, at least in part, to negative cross talk with salicylic acid (SA) and gibberellic acid (GA) pathways. BR-mediated suppression of SA defenses occurred downstream of SA biosynthesis, but upstream of the master defense regulators NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 and OsWRKY45. In contrast, BR alleviated GA-directed immune responses by interfering at multiple levels with GA metabolism, resulting in indirect stabilization of the DELLA protein and central GA repressor SLENDER RICE1 (SLR1). Collectively, these data favor a model whereby P. graminicola coopts the plant BR pathway as a decoy to antagonize effectual SA- and GA-mediated defenses. Our results highlight the importance of BRs in modulating plant immunity and uncover pathogen-mediated manipulation of plant steroid homeostasis as a core virulence strategy.

  1. Industry growth, work role characteristics, and job satisfaction: a cross-level mediation model.

    Science.gov (United States)

    Ford, Michael T; Wooldridge, Jessica D

    2012-10-01

    The associations between industry revenue growth, individual work role characteristics, and job satisfaction were examined in this cross-level mediation analysis. Work roles were expected to be more autonomous, involve greater skill variety, and offer more opportunities for growth and development for workers in growing industries than for workers in declining industries. Supervisor support was also hypothesized to be stronger for workers in high-growth industries. Results from a nationally representative (U.S.) sample of service industry workers, using multilevel modeling, supported these propositions and suggest that job enrichment mediates relations between industry growth and job satisfaction. Associations between industry growth and autonomy were also stronger among workers in occupations that are less normatively autonomous, suggesting that industry growth fosters a weakening, and industry decline a strengthening, of traditional differences in autonomy across work roles. These results contribute to a multilevel perspective on organizational environments, individual work roles, and worker attitudes and well-being.

  2. The Apollo Number: space suits, self-support, and the walk-run transition.

    Directory of Open Access Journals (Sweden)

    Christopher E Carr

    Full Text Available BACKGROUND: How space suits affect the preferred walk-run transition is an open question with relevance to human biomechanics and planetary extravehicular activity. Walking and running energetics differ; in reduced gravity (<0.5 g, running, unlike on Earth, uses less energy per distance than walking. METHODOLOGY/PRINCIPAL FINDINGS: The walk-run transition (denoted * correlates with the Froude Number (Fr = v(2/gL, velocity v, gravitational acceleration g, leg length L. Human unsuited Fr* is relatively constant (approximately 0.5 with gravity but increases substantially with decreasing gravity below approximately 0.4 g, rising to 0.9 in 1/6 g; space suits appear to lower Fr*. Because of pressure forces, space suits partially (1 g or completely (lunar-g support their own weight. We define the Apollo Number (Ap = Fr/M as an expected invariant of locomotion under manipulations of M, the ratio of human-supported to total transported mass. We hypothesize that for lunar suited conditions Ap* but not Fr* will be near 0.9, because the Apollo Number captures the effect of space suit self-support. We used the Apollo Lunar Surface Journal and other sources to identify 38 gait events during lunar exploration for which we could determine gait type (walk/lope/run and calculate Ap. We estimated the binary transition between walk/lope (0 and run (1, yielding Fr* (0.36+/-0.11, mean+/-95% CI and Ap* (0.68+/-0.20. CONCLUSIONS/SIGNIFICANCE: The Apollo Number explains 60% of the difference between suited and unsuited Fr*, appears to capture in large part the effects of space suits on the walk-run transition, and provides several testable predictions for space suit locomotion and, of increasing relevance here on Earth, exoskeleton locomotion. The knowledge of how space suits affect gait transitions can be used to optimize space suits for use on the Moon and Mars.

  3. Effect of hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia on serum pain mediators and placental hypoxia molecules after cesarean section

    Institute of Scientific and Technical Information of China (English)

    Xiao-Hui Yuan; Jian-Guo Xia; Xiao-Yang Jiang

    2017-01-01

    Objective:To study the effect of hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia on serum pain mediators and placental hypoxia molecules after cesarean section.Methods: 126 women accepting cesarean section in our hospital between May 2013 and December 2015 were selected as the research subjects and randomly divided into two groups, observation group of subjects received hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia and control group of subjects accepted bupivacaine combined spinal-epidural anesthesia. 1, 3 and 5 d after delivery, serum was collected to determine the levels of pain mediators; the placenta tissue was collected to detect the levels of oxidative stress molecules and endoplasmic reticulum stress molecules.Results: 1, 3 and 5 d after delivery, serum substance P (SP),β-endorphin (β-EP), 5-hydroxytryptamine (5-HT), nitric oxide (NO) and norepinephrine (NE) levels of observation group were significantly lower than those of control group whileβ-EP levels were significantly higher than those of control group (P<0.05); reactive oxide species (ROS), reactive nitrogen species (RNS), GRP78, ERdj1, CHOP and ASK1 levels in placenta tissue of observation group were significantly lower than those of control group while glutathione peroxidase (GPx), catalase (CAT) and vitamin C (VitC) levels were significantly higher than those of control group (P<0.05).Conclusions: Hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia can adjust the pain mediator secretion, relieve postoperative pain and inhibit oxidative stress and endoplasmic reticulum stress.

  4. Characterization of dynamic thermal control schemes and heat transfer pathways for incorporating variable emissivity electrochromic materials into a space suit heat rejection system

    Science.gov (United States)

    Massina, Christopher James

    radiator architecture is considered to be at a technology readiness level of 3/4, indicating that analytical proof-of-concept and component level validation in a laboratory environment have been completed. While this is not a numeric increase from previous investigations, these contributions are a significant iteration within those levels. These results improve the understanding of the capabilities provided by the full suit, variable emissivity architecture.

  5. Virtual reality simulation training in a high-fidelity procedure suite

    DEFF Research Database (Denmark)

    Lönn, Lars; Edmond, John J; Marco, Jean

    2012-01-01

    To assess the face and content validity of a novel, full physics, full procedural, virtual reality simulation housed in a hybrid procedure suite.......To assess the face and content validity of a novel, full physics, full procedural, virtual reality simulation housed in a hybrid procedure suite....

  6. Corporation suit in administrative proceedings - BVerwG, NJW 1981, 362

    International Nuclear Information System (INIS)

    Skouris, W.

    1982-01-01

    The above mentioned decisions show that the repeated demand for an admission of the corporation suit has not had much impact on jurisdiction. Still the courts are examining whether the rights of corporations taking action against the executive measures are being infringed by them or not. They do not seem to be willing to admit the enforcement of members' rights or of public interests by means of a corporation suit except in those cases that are already embodied in the law. The latest statement of the administrative courts prove that the administrative procedural law (still) in force does not accept any general law on the conduct of a case on behalf of associations for the protection of their members' rights (egoistic corporation suit), nor does it acknowledge the legitimacy of corporations to see against objective illegalities in official decisions with the intention of reducing deficiencies in the execution (altruistic corporation suit). (orig.) [de

  7. FRHAM-TEX trademark cool suit - OST reference No. 1854. Deactivation and decommissioning focus area

    International Nuclear Information System (INIS)

    1998-02-01

    This paper describes a demonstration project for the FRHAM-TEX Cool Suit trademark manufactured by FRHAM Safety Products. It is a one-piece, disposable, breathable, waterproof coverall designed to permit moisture generated by the wearer to be transmitted outside the suit. The performance of this suit was compared to a Tyvek reg-sign suit as a baseline. The suit is proposed as safety ware for workers at decontamination and decommissioning projects

  8. The Mediator Effect Of Depression Level On The Effects Of Work Stress On The Intention Of Leaving Employment Among Education Employee

    Directory of Open Access Journals (Sweden)

    Ahmet Cezmi SAVAS

    2017-12-01

    Full Text Available The purpose of this study is to investigate the effects of depression level on the effects of work stress on the intention of leaving employment among education employee. The sample of the current research includes 67 principals, 79 assistant principals, and 163 teachers who work in various schools in the city center of Gaziantep during 2013-2014 education year. It was found that work stress and depression level were significant predictors of intention of leaving employment. Based on the results that the mediator effect of depression level when the level of work stress of education employee is predicting the intention of leaving of employment, it was found the level of depression is a mediator, and related solutions are presented.

  9. Clinical significance of changes of serum osteocalcin (BGP) levels in subjects of different age-groups

    International Nuclear Information System (INIS)

    Jiang Lihua; Zhang Jin; Han Cuihua; Ouyang Qiaohong

    2006-01-01

    Objective: To investigate the changes of serum BGP levels in different age-groups. Methods: Serum BGP levels were determined with RIA in 306 subjects of different age-groups. Results: The serum BGP levels were highest in subjects of the pre-adolescent group (age5-15, n=60, vs other groups, all P 50, n=80, P<0.001). Levels in the middle age group were the lowest and were significantly lower than those in the old age group (P<0.001). No sex related differences were observed in the pre-adolescent and middle age groups, but in the youth group, serum BGP levels were significantly higher in the males than those in the females (P<0.05). However, in the old age group, the reverse was true i.e. values being significantly higher in the females (vs males, P<0.01). Conclusion: Serum BGP levels varied greatly among the different age groups. (authors)

  10. The small group subtlety of using ICT for participatory governance: A South African experience

    CSIR Research Space (South Africa)

    Twinomurinzi, H

    2012-04-01

    Full Text Available the necessity to re-design ICT to suit small groups as part of participative e-governance rather than the normative ICT design that suits individual work styles. Additionally, the research reveals that by working in groups, communities are more willing to accept...

  11. Anaerobic ammonium oxidation mediated by Mn-oxides: from sediment to strain level.

    Science.gov (United States)

    Javanaud, Cedric; Michotey, Valerie; Guasco, Sophie; Garcia, Nicole; Anschutz, Pierre; Canton, Mathieu; Bonin, Patricia

    2011-11-01

    Nitrite and (29)N(2) productions in slurry incubations of anaerobically sediment after (15)NO(3) or (15)NH(4) labelling in the presence of Mn-oxides suggested that anaerobic Mn-oxides mediated nitrification coupled with denitrification in muddy intertidal sediments of Arcachon Bay (SW Atlantic French coast). From this sediment, bacterial strains were isolated and physiologically characterized in terms of Mn-oxides and nitrate reduction as well as potential anaerobic nitrification. One of the isolated strain, identified as Marinobacter daepoensis strain M4AY14, was a denitrifier. Nitrous oxide production by this strain was demonstrated in the absence of nitrate and with Mn-oxides and NH(4) amendment, giving indirect proof of anaerobic nitrate or nitrite production. Anaerobic Mn-oxide-mediated nitrification was confirmed by (29)N(2) production in the presence of (15)NO(3) and (14)NH(4) under denitrifying conditions. Anaerobic nitrification by M4AY14 seemed to occur only in the absence of nitrate, or at nitrate levels lower than that of Mn-oxides. Most of the other isolates were affiliated with the Shewanella genus and were able to use both nitrate and Mn-oxides as electron acceptors. When both electron acceptors were present, whatever their concentrations, nitrate and Mn-oxide reduction co-occurred. These data indicate that bacterial Mn-oxide reduction could be an important process in marine sediments with low oxygen concentrations, and demonstrate for the first time the role of bacteria in anaerobic Mn-mediated nitrification. Copyright © 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

  12. Coding of level of ambiguity within neural systems mediating choice.

    Science.gov (United States)

    Lopez-Paniagua, Dan; Seger, Carol A

    2013-01-01

    Data from previous neuroimaging studies exploring neural activity associated with uncertainty suggest varying levels of activation associated with changing degrees of uncertainty in neural regions that mediate choice behavior. The present study used a novel task that parametrically controlled the amount of information hidden from the subject; levels of uncertainty ranged from full ambiguity (no information about probability of winning) through multiple levels of partial ambiguity, to a condition of risk only (zero ambiguity with full knowledge of the probability of winning). A parametric analysis compared a linear model in which weighting increased as a function of level of ambiguity, and an inverted-U quadratic models in which partial ambiguity conditions were weighted most heavily. Overall we found that risk and all levels of ambiguity recruited a common "fronto-parietal-striatal" network including regions within the dorsolateral prefrontal cortex, intraparietal sulcus, and dorsal striatum. Activation was greatest across these regions and additional anterior and superior prefrontal regions for the quadratic function which most heavily weighs trials with partial ambiguity. These results suggest that the neural regions involved in decision processes do not merely track the absolute degree ambiguity or type of uncertainty (risk vs. ambiguity). Instead, recruitment of prefrontal regions may result from greater degree of difficulty in conditions of partial ambiguity: when information regarding reward probabilities important for decision making is hidden or not easily obtained the subject must engage in a search for tractable information. Additionally, this study identified regions of activity related to the valuation of potential gains associated with stimuli or options (including the orbitofrontal and medial prefrontal cortices and dorsal striatum) and related to winning (including orbitofrontal cortex and ventral striatum).

  13. Extreme-Environment Silicon-Carbide (SiC) Wireless Sensor Suite

    Science.gov (United States)

    Yang, Jie

    2015-01-01

    Phase II objectives: Develop an integrated silicon-carbide wireless sensor suite capable of in situ measurements of critical characteristics of NTP engine; Compose silicon-carbide wireless sensor suite of: Extreme-environment sensors center, Dedicated high-temperature (450 deg C) silicon-carbide electronics that provide power and signal conditioning capabilities as well as radio frequency modulation and wireless data transmission capabilities center, An onboard energy harvesting system as a power source.

  14. Astronaut Neil Armstrong in Launch Complex 16 trailer during suiting up

    Science.gov (United States)

    1966-01-01

    Astronaut Neil A. Armstrong, command pilot of the Gemini 8 space flight, sits in the Launch Complex 16 trailer during suiting up operations for the Gemini 8 mission. Suit technician Jim Garrepy assists.

  15. Mouse allergen exposure and immunologic responses: IgE-mediated mouse sensitization and mouse specific IgG and IgG4 levels

    NARCIS (Netherlands)

    Matsui, Elizabeth C.; Krop, Esmeralda J. M.; Diette, Gregory B.; Aalberse, Rob C.; Smith, Abigail L.; Eggleston, Peyton A.

    2004-01-01

    Although there is evidence that contact with mice is associated with IgE-mediated mouse sensitization and mouse specific antibody responses, the exposure-response relationships remain unclear. To determine whether IgE-mediated mouse sensitization and mouse specific IgG (mIgG) and mIgG4 levels

  16. Cognitive cooperation groups mediated by computers and internet present significant improvement of cognitive status in older adults with memory complaints: a controlled prospective study

    Directory of Open Access Journals (Sweden)

    Rodrigo de Rosso Krug

    Full Text Available ABSTRACT Objective To estimate the effect of participating in cognitive cooperation groups, mediated by computers and the internet, on the Mini-Mental State Examination (MMSE percent variation of outpatients with memory complaints attending two memory clinics. Methods A prospective controlled intervention study carried out from 2006 to 2013 with 293 elders. The intervention group (n = 160 attended a cognitive cooperation group (20 sessions of 1.5 hours each. The control group (n = 133 received routine medical care. Outcome was the percent variation in the MMSE. Control variables included gender, age, marital status, schooling, hypertension, diabetes, dyslipidaemia, hypothyroidism, depression, vascular diseases, polymedication, use of benzodiazepines, exposure to tobacco, sedentary lifestyle, obesity and functional capacity. The final model was obtained by multivariate linear regression. Results The intervention group obtained an independent positive variation of 24.39% (CI 95% = 14.86/33.91 in the MMSE compared to the control group. Conclusion The results suggested that cognitive cooperation groups, mediated by computers and the internet, are associated with cognitive status improvement of older adults in memory clinics.

  17. Adipokines Do Not Mediate the Association of Obesity and Colorectal Adenoma

    International Nuclear Information System (INIS)

    Balcom, H. M. O.; Cannioto, R.; Nie, J.; Millen, A. E.; Freudenheim, J. L.; Chen, Z.; Thompson, C. L.; Li, L.; Tracy, R.

    2014-01-01

    The association between obesity and colon neoplasia is well established but the underlying biological mechanisms are not fully understood. Rates of both obesity and colon cancer differ by race. Adipokines have been postulated as contributors to the observed association; however, few studies have examined the mediating effect of adipokines on the obesity-colon adenoma association with consideration of racial differences. Methods. We determined prediagnostic levels of adiponectin and leptin in Caucasians (217 cases and 650 controls) and African Americans (175 cases and 378 controls) participating in the Case Transdisciplinary Research on Energetics and Cancer Colon Adenoma Study. We evaluated mediating effects of adiponectin and leptin on the association of abdominal adiposity and colon adenoma separately according to race using mediational pathway analysis. Results. We observed differences in circulating adipokine concentrations by race; African Americans had higher levels of leptin and lower levels of adiponectin than Caucasians for both adenoma cases and controls ( P values <0.001). Leptin and adiponectin did not mediate the waist-to-hip ratio (WHR) adenoma association in either group (all Sobel P values >0.27). Conclusions. We found no evidence that leptin or adiponectin mediates the abdominal obesity-colorectal adenoma pathway. Larger studies on how these associations vary by race, sex, and obesity are needed.

  18. Heat and mass transfer in air-fed pressurised suits

    International Nuclear Information System (INIS)

    Tesch, K.; Collins, M.W.; Karayiannis, T.G.; Atherton, M.A.; Edwards, P.

    2009-01-01

    Air-fed pressurised suits are used to protect workers against contamination and hazardous environments. The specific application here is the necessity for regular clean-up maintenance within the torus chamber of fusion reactors. The current design of suiting has been developed empirically. It is, therefore, very desirable to formulate a thermo-fluids model, which will be able to define optimum designs and operating parameters. Two factors indicate that the modelling should be as comprehensive as possible. Firstly, the overall thermo-fluids problem is three-dimensional and includes mass as well as heat transfer. The fluid field is complex, bounded on one side by the human body and on the other by what may be distensible, porous and multi-layer clothing. In this paper, we report firstly the modelling necessary for the additional mass and heat transport processes. This involves the use of Fick's and Fourier's laws and conjugate heat transfer. The results of an initial validation study are presented. Temperatures at the outlet of the suits were obtained experimentally and compared with those predicted by the overall CFD model. Realistic three-dimensional geometries were used for the suit and human body. Calculations were for turbulent flow with single- and two-component (species) models

  19. [Hygienic substantiation of the permissible levels for tetracycline-group antibiotics in food].

    Science.gov (United States)

    Onishchenko, G G; Sheveleva, S A; Khotimchenko, S A

    2012-01-01

    For the purpose of justification of the hygienic standard for tetracycline-group antibiotics in the food production established in the Russian Federation at more rigid level, than maximum and admissible levels (MAL) of the Codex Alimentarius Commission, the analysis of data of literature on negative nature of impact of low concentration of these antibiotics on an organism and the environmental conditions and risk for health has been performed. Inadequacy of the accepted admissible daily dose (ADD) accepted by The Joint FAO/WHO Expert Committee on Food Additives (JECFA) on action on selection of resistant E. coli in intestines, for the wide contingent of consumers in connection with ignoring of obvious factors of uncertainty (gastrointestinal dysbiosis, age and individual variations in the microbiota of people synergy with other antibiotics residues in food and indirect impact on an organism through microflora from the natural habitat (resistance genes, modified causative organisms with altered properties).. By the analysis of information received with the use of modern molecular and genetic methods, the role of Subinhibitory concentrations (sub-MICs) of tetracyclines as biologically active substances, signaling molecules which, without causing obvious negative consequences in a macroorganism, serve as a major factor of regulation of a transcription in microorganisms and activation of a horizontal gene transfer coding resistance, transferred on conjugative transposons of Tn916-Tn1545 family. Reasonable scientific data on a dominating contribution of minor levels of tetracyclines in globalization in the nature of the most adverse transmissive type of the antibiotic resistance interfaced to formation new bacterial pathotypes, as consequences of irrationally high scales of application in agriculture and strengthened impact on microbic ecosystems of live organisms and objects of habitat are presented. For minimization of this mediated risk for health the need of

  20. Examination of group cohesiveness levels and goal orientations of basketball players

    Directory of Open Access Journals (Sweden)

    Ötkan Can Çavin

    2017-01-01

    Full Text Available This research intends to examine goal orientation and group cohesiveness levels of basketball players. 243 mature players who play in the leagues of Turkish Basketball Federation in 2016- 2017 season participated the study. “Task and Ego Orientation in Sports” and “Group Cohesiveness” questionnaires are used in study. While frequency, arithmetic mean and standard deviation is used for the analysis of data, T-Test, One-Way Analysis of Variance (ANOVA and Post-Hoc test statistics (Tukey HSD are used for independent samples. Depending on the variables of gender and educational background of players, a significant difference is identified in sub-dimension of Task Attraction of Group and a low-level negatively significant difference is identified between Ego Orientation in terms of age and sportive age. Significant differences are identified between the Perception of Team Success and sub-dimensions of Social Integration of Group and Social Attraction of Group. No statistically significant difference can be found for the variable of time spent in team in terms of group cohesiveness and goal orientation.

  1. Core level shifts in group IV semiconductors and semimetals

    International Nuclear Information System (INIS)

    Yin, S.; Tosatti, E.

    1981-08-01

    We calculate the core level binding energy shift from the isolated atom to the crystalline solid, for group IV elemental semiconductors. This is done by simple extension of Johansson and Martensson's scheme for metals. We show that the core level energy in a nonmetal must be measured by the photo absorption (''core exciton'') threshold rather than by photo emission. As a byproduct, a simple scheme is also devised to evaluate impurity heats of solutions in semiconductors. (author)

  2. STS-74 M.S. Jerry L. Ross suits up

    Science.gov (United States)

    1995-01-01

    Spaceflight veteran Jerry L. Ross, Mission Specialist 2 on Shuttle Mission STS-74, is assisted by a suit technician as he finishes getting into his launch/entry suit in the Operations and Checkout Building. Ross and four fellow astronauts will depart shortly for Launch Pad 39A, where the Space Shuttle Atlantis awaits a second liftoff attempt during a seven-minute window scheduled to open at approximately 7:30 a.m. EST, Nov. 12.

  3. The Effect of Education Level on Psychological Empowerment and Burnout-The Mediating Role of Workplace Learning Behaviors

    OpenAIRE

    Sarit Rashkovits; Yael Livne

    2013-01-01

    The study investigates the relationship between education level, workplace learning behaviors, psychological empowerment and burnout in a sample of 191 teachers. We hypothesized that education level will positively affect psychological state of increased empowerment and decreased burnout, and we purposed that these effects will be mediated by workplace learning behaviors. We used multiple regression analyses to test the model that included also the 6 following control var...

  4. Three-Dimensions vs. Two-Dimensions Intervention Programs: The Effect on the Mediation Level and Behavioural Aspects of Children with Intellectual Disability

    Science.gov (United States)

    Eden, S.; Bezer, M.

    2011-01-01

    The research examined the effect of an intervention program employing 3D immersive virtual reality (IVR), which focused on the perception of sequential time, on the mediation level and behavioural aspects of children with intellectual disability (ID). The intervention is based on the mediated learning experience (MLE) theory, which refers the…

  5. Learning DHTMLX suite UI

    CERN Document Server

    Geske, Eli

    2013-01-01

    A fast-paced, example-based guide to learning DHTMLX.""Learning DHTMLX Suite UI"" is for web designers who have a basic knowledge of JavaScript and who are looking for powerful tools that will give them an extra edge in their own application development. This book is also useful for experienced developers who wish to get started with DHTMLX without going through the trouble of learning its quirks through trial and error. Readers are expected to have some knowledge of JavaScript, HTML, Document Object Model, and the ability to install a local web server.

  6. Two ways related to performance in elite sport: the path of self-confidence and competitive anxiety and the path of group cohesion and group goal-clarity.

    Science.gov (United States)

    Kjørmo, Odd; Halvari, Hallgeir

    2002-06-01

    A model tested among 136 Norwegian Olympic-level athletes yielded two paths related to performance. The first path indicated that self-confidence, modeled as an antecedent of competitive anxiety, is negatively correlated with anxiety. Competitive anxiety in turn is negatively correlated with performance. The second path indicated that group cohesion is positively correlated with group goal-clarity, which in turn is positively correlated with performance. Competitive anxiety mediates the relation between self-confidence and performance, whereas group goal-clarity mediates the relation between group cohesion and performance. Results from multiple regression analyses supported the model in the total sample and among individual sport athletes organized in training groups (n = 100). Among team sport athletes (n = 36), personality and group measures are more strongly intercorrelated than among individual sport athletes, and the relation with performance is more complex for the former group. The interaction of self-confidence and competitive anxiety is related to performance among team sport athletes.

  7. Callous-Unemotional Traits and Effortful Control Mediate the Effect of Parenting Intervention on Preschool Conduct Problems.

    Science.gov (United States)

    Elizur, Yoel; Somech, Lior Y

    2018-02-24

    Parenting intervention (PI) is an effective treatment for children's conduct problems (CP) that has been shown to be mediated by improved parenting practices and parenting self-efficacy. Recently, Hitkashrut's randomized controlled trial demonstrated that ineffective parenting (IP) mediated effects on callous-unemotional (CU) traits and effortful control (EC), while controlling for more general treatment effects on CP. These temperament and personality-based features predict the formation of early-onset antisocial trajectories with poor long-term prognosis. The objective of this study was to use Hitkashrut's 3-wave dataset to test posttreatment EC and CU mediation of treatment effect on 1-year follow-up CP, and to determine whether mediation by each child-level potential mediator remains significant when tested concurrently with the parenting mediator. Parents of 209 3-5 year-old preschoolers (163 boys; 46 girls), with subclinical-clinical range CP were assigned to 14-session co-parent training groups (n = 140 couples), or to minimal intervention control groups (n = 69 couples). Assessments were based on both parents' questionnaires. An intent-to-treat analysis showed that EC and CU traits simultaneously mediated treatment effects on CP in one EC/CU mediational model. The concurrent testing of child- and parent-level mediators showed mediation by IP and CU traits in the CU/IP model, and IP mediation in the EC/IP model. Similar results were obtained in mediational analyses that controlled for the shared variance between the mediators and CP at T2. Overall, the findings support an intervention model of coaching parents of high-CP children to promote moral self-regulatory competencies while concurrently applying behavioral methods that directly target CP.

  8. Individual and group-level job resources and their relationships with individual work engagement.

    Science.gov (United States)

    Füllemann, Désirée; Brauchli, Rebecca; Jenny, Gregor J; Bauer, Georg F

    2016-06-16

    This study adds a multilevel perspective to the well-researched individual-level relationship between job resources and work engagement. In addition, we explored whether individual job resources cluster within work groups because of a shared psychosocial environment and investigated whether a resource-rich psychosocial work group environment is beneficial for employee engagement over and above the beneficial effect of individual job resources and independent of their variability within groups. Data of 1,219 employees nested in 103 work groups were obtained from a baseline employee survey of a large stress management intervention project implemented in six medium and large-sized organizations in diverse sectors. A variety of important job resources were assessed and grouped to an overall job resource factor with three subfactors (manager behavior, peer behavior, and task-related resources). Data were analyzed using multilevel random coefficient modeling. The results indicated that job resources cluster within work groups and can be aggregated to a group-level job resources construct. However, a resource-rich environment, indicated by high group-level job resources, did not additionally benefit employee work engagement but on the contrary, was negatively related to it. On the basis of this unexpected result, replication studies are encouraged and suggestions for future studies on possible underlying within-group processes are discussed. The study supports the presumed value of integrating work group as a relevant psychosocial environment into the motivational process and indicates a need to further investigate emergent processes involved in aggregation procedures across levels.

  9. Effect of swimming suit design on the energy demands of swimming.

    Science.gov (United States)

    Starling, R D; Costill, D L; Trappe, T A; Jozsi, A C; Trappe, S W; Goodpaster, B H

    1995-07-01

    Eight competitive male swimmers completed a standardized 365.8 m (400 yd) freestyle swimming trial at a fixed pace (approximately 90% of maximal effort) while wearing a torso swim suit (TOR) or a standard racing suit (STD). Oxygen uptake (VO2), blood lactate, heart rate (HR), and distance per stroke (DPS) measurements were obtained. In addition, a video-computer system was used to collect velocity data during a prone underwater glide following a maximal leg push-off from the side of the pool while wearing the TOR and STD suits. These data were used to calculate the total distance covered during the glides. VO2 (3.76 +/- 0.16 vs 3.92 +/- 0.18 l.min-1) and lactate (8.08 +/- 0.53 vs, 9.66 +/- 0.66 mM) were significantly (P 0.05) between the TOR (170.1 +/- 5.1 b.min-1) and STD (173.5 +/- 5.7 b.min-1) trials. DPS was significantly greater during the TOR (2.70 +/- 0.066 m.stroke-1) versus STD (2.58 +/- 0.054 m.stroke-1) trial. A significantly greater total distance was covered during the prone glide while wearing the TOR (2.05 +/- 0.067 m) compared to the STD (2.00 +/- 0.080 m) suit. These findings demonstrate that a specially designed torso suit reduces the energy demand of swimming compared to a standard racing suit which may be due to a reduction in body drag.

  10. 28 CFR 36.501 - Private suits.

    Science.gov (United States)

    2010-07-01

    ... ACCOMMODATIONS AND IN COMMERCIAL FACILITIES Enforcement § 36.501 Private suits. (a) General. Any person who is... order. Upon timely application, the court may, in its discretion, permit the Attorney General to... general public importance. Upon application by the complainant and in such circumstances as the court may...

  11. Effect of hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia on serum pain mediators and placental hypoxia molecules after cesarean section

    Directory of Open Access Journals (Sweden)

    Xiao-Hui Yuan

    2017-05-01

    Full Text Available Objective: To study the effect of hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia on serum pain mediators and placental hypoxia molecules after cesarean section. Methods: 126 women accepting cesarean section in our hospital between May 2013 and December 2015 were selected as the research subjects and randomly divided into two groups, observation group of subjects received hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia and control group of subjects accepted bupivacaine combined spinal-epidural anesthesia. 1, 3 and 5 d after delivery, serum was collected to determine the levels of pain mediators; the placenta tissue was collected to detect the levels of oxidative stress molecules and endoplasmic reticulum stress molecules. Results: 1, 3 and 5 d after delivery, serum substance P (SP, β-endorphin (β-EP, 5-hydroxytryptamine (5-HT, nitric oxide (NO and norepinephrine (NE levels of observation group were significantly lower than those of control group while β-EP levels were significantly higher than those of control group (P<0.05; reactive oxide species (ROS, reactive nitrogen species (RNS, GRP78, ERdj1, CHOP and ASK1 levels in placenta tissue of observation group were significantly lower than those of control group while glutathione peroxidase (GPx, catalase (CAT and vitamin C (VitC levels were significantly higher than those of control group (P<0.05. Conclusions: Hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia can adjust the pain mediator secretion, relieve postoperative pain and inhibit oxidative stress and endoplasmic reticulum stress.

  12. Clementine sensor suite

    Energy Technology Data Exchange (ETDEWEB)

    Ledebuhr, A.G. [Lawrence Livermore National Lab., CA (United States)

    1994-11-15

    LLNL designed and built the suite of six miniaturized light-weight space-qualified sensors utilized in the Clementine mission. A major goal of the Clementine program was to demonstrate technologies originally developed for Ballistic Missile Defense Organization Programs. These sensors were modified to gather data from the moon. This overview presents each of these sensors and some preliminary on-orbit performance estimates. The basic subsystems of these sensors include optical baffles to reject off-axis stray light, light-weight ruggedized optical systems, filter wheel assemblies, radiation tolerant focal plane arrays, radiation hardened control and readout electronics and low mass and power mechanical cryogenic coolers for the infrared sensors. Descriptions of each sensor type are given along with design specifications, photographs and on-orbit data collected.

  13. Mindfulness-Based Cancer Recovery (MBCR) versus Supportive Expressive Group Therapy (SET) for distressed breast cancer survivors: evaluating mindfulness and social support as mediators.

    Science.gov (United States)

    Schellekens, Melanie P J; Tamagawa, Rie; Labelle, Laura E; Speca, Michael; Stephen, Joanne; Drysdale, Elaine; Sample, Sarah; Pickering, Barbara; Dirkse, Dale; Savage, Linette Lawlor; Carlson, Linda E

    2017-06-01

    Despite growing evidence in support of mindfulness as an underlying mechanism of mindfulness-based interventions (MBIs), it has been suggested that nonspecific therapeutic factors, such as the experience of social support, may contribute to the positive effects of MBIs. In the present study, we examined whether change in mindfulness and/or social support mediated the effect of Mindfulness-Based Cancer Recovery (MBCR) compared to another active intervention (i.e. Supportive Expressive Group Therapy (SET)), on change in mood disturbance, stress symptoms and quality of life. A secondary analysis was conducted of a multi-site randomized clinical trial investigating the impacts of MBCR and SET on distressed breast cancer survivors (MINDSET). We applied the causal steps approach with bootstrapping to test mediation, using pre- and post-intervention questionnaire data of the participants who were randomised to MBCR (n = 69) or SET (n = 70). MBCR participants improved significantly more on mood disturbance, stress symptoms and social support, but not on quality of life or mindfulness, compared to SET participants. Increased social support partially mediated the impact of MBCR versus SET on mood disturbance and stress symptoms. Because no group differences on mindfulness and quality of life were observed, no mediation analyses were performed on these variables. Findings showed that increased social support was related to more improvement in mood and stress after MBCR compared to support groups, whereas changes in mindfulness were not. This suggests a more important role for social support in enhancing outcomes in MBCR than previously thought.

  14. Results and Analysis from Space Suit Joint Torque Testing

    Science.gov (United States)

    Matty, Jennifer

    2010-01-01

    This joint mobility KC lecture included information from two papers, "A Method for and Issues Associated with the Determination of Space Suit Joint Requirements" and "Results and Analysis from Space Suit Joint Torque Testing," as presented for the International Conference on Environmental Systems in 2009 and 2010, respectively. The first paper discusses historical joint torque testing methodologies and approaches that were tested in 2008 and 2009. The second paper discusses the testing that was completed in 2009 and 2010.

  15. A Test Suite for Safety-Critical Java using JML

    DEFF Research Database (Denmark)

    Ravn, Anders Peter; Søndergaard, Hans

    2013-01-01

    Development techniques are presented for a test suite for the draft specification of the Java profile for Safety-Critical Systems. Distinguishing features are: specification of conformance constraints in the Java Modeling Language, encoding of infrastructure concepts without implementation bias......, and corresponding specifications of implicitly stated behavioral and real-time properties. The test programs are auto-generated from the specification, while concrete values for test parameters are selected manually. The suite is open source and publicly accessible....

  16. DEMON/ANGEL - A SUITE OF PROGRAMS TO CARRY OUT DENSITY MODIFICATION

    NARCIS (Netherlands)

    VELLIEUX, FMDAP; HUNT, JF; ROY, S; READ, RJ

    1995-01-01

    The DEMON/ANGEL suite of computer programs has been developed to carry out density modification by non-crystallographic symmetry-averaging, solvent-flattening and histogram-mapping techniques. This suite consists of programs that allow molecular envelopes to be defined and modified,

  17. Lower body positive pressure application with an antigravity suit in acute carotid occlusion.

    Science.gov (United States)

    Berthet, Karine; Lukaszewicz, Anne Claire; Bousser, Marie-Germaine; Payen, Didier

    2010-04-01

    The challenge in acute stroke is still to reperfuse as early as possible the ischemic territory. Since fibrinolytic therapies have a limited window with potential risk of bleeding, having a nonpharmacologic mean to recruit vessels in area surrounding necrosis might be useful. We propose here to use antigravity suit inflated at "venous" pressure levels to shift blood towards thoracic and brain territories. We report two cases of spectacular clinical recovery after acute carotid occlusion.

  18. An intermediary enhances out-group trust and in-group profit expectation of Chinese but not Australians.

    Science.gov (United States)

    Ye, Jiawen; Ng, Sik Hung

    2017-06-01

    In this research, we made a theoretical distinction between direct and intermediary-mediated trust situations, and conducted a cross-cultural (Chinese vs. Australians) investment trust game to test the overlooked effects of an intermediary on investors' trust decisions, with respect to how much to invest in and expect from trustees. Compared to situations of direct trust, a nominal intermediary increased the number of Chinese investors expecting in-group trustees to repay a profit on their investments (Hypothesis 1) and raised their level of investment in out-group trustees (Hypothesis 2). These results applied to Chinese, but not Australians in support of the proposal that a nominal intermediary would serve as a cue to activate different cultural stereotypes of the functions and meanings of an intermediary with respect to trust and expectation of reciprocity. Coexisting with these culture-specific effects of an intermediary, the minimal categorisation of people into in-group and out-group on trivial grounds leads to a highly significant in-group favouritism in investment levels of both Chinese and Australians (Hypothesis 3). © 2015 International Union of Psychological Science.

  19. A multilevel perspective on faultlines: Differentiating the effects between group- and organizational-level faultlines.

    Science.gov (United States)

    Bezrukova, Katerina; Spell, Chester S; Caldwell, David; Burger, Jerry M

    2016-01-01

    Integrating the literature on faultlines, conflict, and pay, we drew on the basic principles of multilevel theory and differentiated between group- and organizational-level faultlines to introduce a novel multilevel perspective on faultlines. Using multisource, multilevel data on 30 Major League Baseball (MLB) teams, we found that group-level faultlines were negatively associated with group performance, and that internally focused conflict exacerbated but externally focused conflict mitigated this effect. Organizational-level faultlines were negatively related to organizational performance, and were most harmful in organizations with high levels of compensation. Implications for groups and teams in the sports/entertainment and other industries are discussed. (c) 2016 APA, all rights reserved).

  20. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2003-01-01

    This study analyzes how a group of ‘mediators’ in a large, multinational company adapted a computer-mediated communication technology (a ‘virtual workspace’) to the organizational context (and vice versa) by modifying features of the technology, providing ongoing support for users, and promoting...... appropriate conventions of use. Our findings corroborate earlier research on technology-use mediation, which suggests that such mediators can exert considerable influence on how a particular technology will be established and used in an organization. However, this study also indicates that the process...... of technology-use mediation is more complex and indeterminate than earlier literature suggests. In particular, we want to draw attention to the fact that advanced computer-mediated communication technologies are equivocal and that technology-use mediation consequently requires ongoing sensemaking (Weick 1995)....

  1. Extending and Enhancing SAS (Static Analysis Suite)

    CERN Document Server

    Ho, David

    2016-01-01

    The Static Analysis Suite (SAS) is an open-source software package used to perform static analysis on C and C++ code, helping to ensure safety, readability and maintainability. In this Summer Student project, SAS was enhanced to improve ease of use and user customisation. A straightforward method of integrating static analysis into a project at compilation time was provided using the automated build tool CMake. The process of adding checkers to the suite was streamlined and simplied by developing an automatic code generator. To make SAS more suitable for continuous integration, a reporting mechanism summarising results was added. This suitability has been demonstrated by inclusion of SAS in the Future Circular Collider Software nightly build system. Scalability of the improved package was demonstrated by using the tool to analyse the ROOT code base.

  2. REDUCTION OF CLASSROOM NOISE LEVELS USING GROUP CONTINGENCIES

    OpenAIRE

    Ring, Brandon M.; Sigurdsson, Sigurdur O.; Eubanks, Sean L.; Silverman, Kenneth

    2014-01-01

    The therapeutic workplace is an employment-based abstinence reinforcement intervention for unemployed drug users where trainees receive on-the-job employment skills training in a classroom setting. The study is an extension of prior therapeutic workplace research, which suggested that trainees frequently violated noise standards. Participants received real-time graphed feedback of noise levels and had the opportunity to earn monetary group reinforcement for maintaining a low number of noise v...

  3. CW-FIT: Group Contingency Effects across the Day

    Science.gov (United States)

    Wills, Howard P.; Iwaszuk, Wendy M.; Kamps, Debra; Shumate, Emily

    2014-01-01

    This study explored the effects of a group-contingency intervention on student behavior across academic instructional periods. Research suggests group contingencies are evidence-based practices, yet calls for investigation to determine the best conditions and groups suited for this type of intervention. CW-FIT (Class-Wide Function-related…

  4. STS-76 Payload Cmdr Ronald Sega suits up

    Science.gov (United States)

    1996-01-01

    STS-76 Payload Commander Ronald M. Sega is donning his launch/entry suit in the Operations and Checkout Building with assistance from a suit technician. The third docking between the Russian Space Station Mir and the U.S. Space Shuttle marks the second trip into space for Sega, who recently served a five-month assignment in Russia as operations director for NASA activities there. Once suitup activities are completed the six-member STS-76 flight crew will depart for Launch Pad 39B, where the Space Shuttle Atlantis is undergoing final preparations for liftoff during an approximately seven-minute launch window opening around 3:13 a.m. EST, March 22.

  5. What's New with MS Office Suites

    Science.gov (United States)

    Goldsborough, Reid

    2012-01-01

    If one buys a new PC, laptop, or netbook computer today, it probably comes preloaded with Microsoft Office 2010 Starter Edition. This is a significantly limited, advertising-laden version of Microsoft's suite of productivity programs, Microsoft Office. This continues the trend of PC makers providing ever more crippled versions of Microsoft's…

  6. Antigravity Suits For Studies Of Weightlessness

    Science.gov (United States)

    Kravik, Stein E.; Greenleaf, John

    1992-01-01

    Report presents results of research on use of "antigravity" suit, one applying positive pressure to lower body to simulate some effects of microgravity. Research suggests lower-body positive pressure is alternative to bed rest or immersion in water in terrestrial studies of cardioregulatory, renal, electrolyte, and hormonal changes induced in humans by microgravity.

  7. Perfectionism, selected demographic and job characteristics as predictors of burnout in operating suite nurses

    Directory of Open Access Journals (Sweden)

    Dorota Włodarczyk

    2013-12-01

    Full Text Available Background: The study was aimed at verifying the predictive power of perfectionism for professional burnout among nurses exposed to distress resulting from work in an operating suite and testing whether this effect exists after controlling for selected demographic and job characteristics. Material and Methods: The study group consisted of 100 nurses (93 women; mean age: 38.67 years. The majority in the group worked in public facilities (68%, in duty system (62%, as operating (75% or anesthesiology (25% nurses. To test perfectionism The Polish Adaptive and Maladaptive Perfectionism Questionnaire (AMPQ (Perfekcjonizm Adaptacyjny i Dezadaptacyjny - PAD, developed by Szczucka, was used. To examine burnout the Oldenburg Burnout Inventory (OLBI by Demerouti et al. was adopted. The effects of selected demographic and job characteristics were controlled. Results: The results of hierarchical regression analyses revealed that after controlling for selected demographic and job characteristics maladaptive perfectionism was a significant predictor of disengagement and exhaustion whereas adaptive perfectionism predicted a better work engagement. Significant predictors were also: education, number of workplaces, duty system and marital status. Conclusions: The study allowed to confirm the hypothesis on a harmful role of maladaptive perfectionism in shaping burnout among operating suite nurses. The hypothesis on protective function of adaptive perfectionism was confirmed only partially, with regard to disengagement. The results of the study also highlighted some risk factors of burnout which may exist in this occupational group. This confirms the need to continue research in this area. Med Pr 2013;64(6:761–773

  8. Multi-level iteration optimization for diffusive critical calculation

    International Nuclear Information System (INIS)

    Li Yunzhao; Wu Hongchun; Cao Liangzhi; Zheng Youqi

    2013-01-01

    In nuclear reactor core neutron diffusion calculation, there are usually at least three levels of iterations, namely the fission source iteration, the multi-group scattering source iteration and the within-group iteration. Unnecessary calculations occur if the inner iterations are converged extremely tight. But the convergence of the outer iteration may be affected if the inner ones are converged insufficiently tight. Thus, a common scheme suit for most of the problems was proposed in this work to automatically find the optimized settings. The basic idea is to optimize the relative error tolerance of the inner iteration based on the corresponding convergence rate of the outer iteration. Numerical results of a typical thermal neutron reactor core problem and a fast neutron reactor core problem demonstrate the effectiveness of this algorithm in the variational nodal method code NODAL with the Gauss-Seidel left preconditioned multi-group GMRES algorithm. The multi-level iteration optimization scheme reduces the number of multi-group and within-group iterations respectively by a factor of about 1-2 and 5-21. (authors)

  9. 33 CFR 144.20-5 - Exposure suits.

    Science.gov (United States)

    2010-07-01

    ... light that is approved under 46 CFR 161.012. Each light must be securely attached to the front shoulder... lanyard coiled and stopped off. (f) No stowage container for exposure suits may be capable of being locked...

  10. Modeling the Impact of Space Suit Components and Anthropometry on the Center of Mass of a Seated Crewmember

    Science.gov (United States)

    Rajulu, Sudhakar; Blackledge, Christopher; Ferrer, Mike; Margerum, Sarah

    2009-01-01

    The designers of the Orion Crew Exploration Vehicle (CEV) utilize an intensive simulation program in order to predict the launch and landing characteristics of the Crew Impact Attenuation System (CIAS). The CIAS is the energy absorbing strut concept that dampens loads to levels sustainable by the crew during landing and consists of the crew module seat pallet that accommodates four to six seated astronauts. An important parameter required for proper dynamic modeling of the CIAS is knowledge of the suited center of mass (COM) variations within the crew population. Significant center of mass variations across suited crew configurations would amplify the inertial effects of the pallet and potentially create unacceptable crew loading during launch and landing. Established suited, whole-body, and posture-based mass properties were not available due to the uncertainty of the final CEV seat posture and suit hardware configurations. While unsuited segmental center of mass values can be obtained via regression equations from previous studies, building them into a model that was posture dependent with custom anthropometry and integrated suit components proved cumbersome and time consuming. Therefore, the objective of this study was to quantify the effects of posture, suit components, and the expected range of anthropometry on the center of mass of a seated individual. Several elements are required for the COM calculation of a suited human in a seated position: anthropometry; body segment mass; suit component mass; suit component location relative to the body; and joint angles defining the seated posture. Anthropometry and body segment masses used in this study were taken from a selection of three-dimensional human body models, called boundary manikins, which were developed in a previous project. These boundary manikins represent the critical anthropometric dimension extremes for the anticipated astronaut population. Six male manikins and 6 female manikins, representing a

  11. Evaluation of Triathlon Suit Characteristics Relevant to Thermophysiology of an Athlete

    Directory of Open Access Journals (Sweden)

    Chris Watson

    2018-02-01

    Full Text Available The thermophysiological function of clothing influences athletic wellbeing and performance, particularly in outdoor endurance activities such as triathlon. However, there is very little existing research on the performance of triathlon suits relative to thermophysiological function of the wearer. This pilot study provides a benchmark for triathlon suit performance and insights into improving the suit design and material engineering. The study assessed the thermal and breathability attributes of 6 triathlon suits and concluded that while both of the attributes were similar overall, they varied in different body zones due to different design, construction and materials. Local thermal and evaporative performance were affected by fabric construction; double fabric layering in the stomach panel; the number, size, shape and material structure of rear pockets; cycle crotch pad size, shape and thickness; and panel design. The results of this study show the importance of garment design, construction and materials for the best thermal and evaporative resistance attributes of sportswear.

  12. Family Resources and Mid-Life Level of Education: A Longitudinal Study of the Mediating Influence of Childhood Parental Involvement

    Science.gov (United States)

    von Otter, Cecilia

    2014-01-01

    This paper draws on the concept of parental involvement, popular among educators and policy-makers, in investigating differences in level of attained education by family background. The question is if parental involvement in children's schooling at age 14 acts as a mediator between family resources and mid-life level of attained education. Using…

  13. STS-82 Pilot Scott J. 'Doc' Horowitz Suit Up

    Science.gov (United States)

    1997-01-01

    STS-82 Pilot Scott J. 'Doc' Horowitz puts on a glove of his launch and entry suit with assistance from a suit technician in the Operations and Checkout Building. This is Horowitz''';s second space flight. He and the six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Discovery awaits liftoff on a 10-day mission to service the orbiting Hubble Space Telescope (HST). This will be the second HST servicing mission. Four back-to-back spacewalks are planned.

  14. Surgical Space Suits Increase Particle and Microbiological Emission Rates in a Simulated Surgical Environment.

    Science.gov (United States)

    Vijaysegaran, Praveen; Knibbs, Luke D; Morawska, Lidia; Crawford, Ross W

    2018-05-01

    The role of space suits in the prevention of orthopedic prosthetic joint infection remains unclear. Recent evidence suggests that space suits may in fact contribute to increased infection rates, with bioaerosol emissions from space suits identified as a potential cause. This study aimed to compare the particle and microbiological emission rates (PER and MER) of space suits and standard surgical clothing. A comparison of emission rates between space suits and standard surgical clothing was performed in a simulated surgical environment during 5 separate experiments. Particle counts were analyzed with 2 separate particle counters capable of detecting particles between 0.1 and 20 μm. An Andersen impactor was used to sample bacteria, with culture counts performed at 24 and 48 hours. Four experiments consistently showed statistically significant increases in both PER and MER when space suits are used compared with standard surgical clothing. One experiment showed inconsistent results, with a trend toward increases in both PER and MER when space suits are used compared with standard surgical clothing. Space suits cause increased PER and MER compared with standard surgical clothing. This finding provides mechanistic evidence to support the increased prosthetic joint infection rates observed in clinical studies. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Lower Body Positive Pressure Application with an Antigravity Suit in Acute Carotid Occlusion

    Directory of Open Access Journals (Sweden)

    Karine Berthet

    2010-01-01

    Full Text Available The challenge in acute stroke is still to reperfuse as early as possible the ischemic territory. Since fibrinolytic therapies have a limited window with potential risk of bleeding, having a nonpharmacologic mean to recruit vessels in area surrounding necrosis might be useful. We propose here to use antigravity suit inflated at “venous” pressure levels to shift blood towards thoracic and brain territories. We report two cases of spectacular clinical recovery after acute carotid occlusion.

  16. Group differences in the legitimization of inequality: Questioning the role of social dominance orientation.

    Science.gov (United States)

    Pehrson, Samuel; Carvacho, Héctor; Sibley, Chris G

    2017-03-01

    Social dominance orientation (SDO) is conceived as an individual's level of support for group-based hierarchy in general that causes support for more specific group hierarchies. According to social dominance theory, group differences in SDO underpin ideological and behavioural group differences related to specific group hierarchies. Using representative 5-year longitudinal panel data from New Zealand (N = 3,384), we test whether SDO mediates effects of sex and ethnicity on legitimizing myths (LMs) relating to gender and ethnic hierarchy over time. The SDO mediation hypothesis is supported in the case of hostile sexism. However, it is unsupported in the case of benevolent sexism and LMs relating to ethnic hierarchy, where there was no cross-lagged effect of SDO. Moreover, being in the dominant ethnic group is associated with more legitimization of ethnic hierarchy but less legitimization of gender hierarchy, which is inconsistent with the notion of a general orientation underpinning group differences in legitimation. There was mixed evidence for a reverse path whereby specific LMs mediate group differences in SDO across time. We argue for the need to find alternative ways to theorize ideological consensus and difference between groups. © 2016 The British Psychological Society.

  17. Court rules against failed viatical firm in investor suit.

    Science.gov (United States)

    1999-10-01

    A Federal appeals court has revived a claim against Dignity Partners Inc., a viatical business, and offshoot of a financial-services firm. Dignity Partners operated by buying the life insurance policies of terminally ill people. The company was charged with making false and misleading statements in its prospectus for an initial public stock offering. Five months later, the company announced that it would not accept new customers with AIDS, a group which represented 95 percent of its accounts at that time. The company had information from researchers and clinicians that the introduction of protease inhibitors would greatly increase life expectancy for its customers and would reduce company profits. This information was not generally available to potential investors. The suit against the company alleges violations of the Securities Act of 1933 and the Exchange Act of 1934, both which govern stock trading.

  18. Perceived Parenting Styles Fail to Mediate Between Anxiety and Attachment Styles in Adult Siblings of Individuals with Developmental Disabilities.

    Science.gov (United States)

    O'Neill, Linda P; Murray, Lindsay E

    2016-09-01

    Adult siblings of individuals with developmental disabilities often experience higher levels of anxiety than individuals in the general population. The present study tested whether perceived parenting could mediate the relationship between attachment styles and anxiety in the sibling group compared to a control group. Little association was found between perceived parenting and attachment styles or anxiety for the siblings but there were robust and expected findings for the control. Adult attachment-related-anxiety was a significant unique predictor of anxiety in the sibling group but there was no mediational role for perceived parenting. Conversely, the majority of parenting styles significantly mediated the relationship between attachment and anxiety in the control. Implications for the atypical findings in the sibling group are discussed.

  19. The European space suit, a design for productivity and crew safety

    Science.gov (United States)

    Skoog, A. Ingemar; Berthier, S.; Ollivier, Y.

    In order to fulfil the two major mission objectives, i.e. support planned and unplanned external servicing of the COLUMBUS FFL and support the HERMES vehicle for safety critical operations and emergencies, the European Space Suit System baseline configuration incorporates a number of design features, which shall enhance the productivity and the crew safety of EVA astronauts. The work in EVA is today - and will be for several years - a manual work. Consequently, to improve productivity, the first challenge is to design a suit enclosure which minimizes movement restrictions and crew fatigue. It is covered by the "ergonomic" aspect of the suit design. Furthermore, it is also necessary to help the EVA crewmember in his work, by giving him the right information at the right time. Many solutions exist in this field of Man-Machine Interface, from a very simple system, based on cuff check lists, up to advanced systems, including Head-Up Displays. The design concept for improved productivity encompasses following features: • easy donning/doffing thru rear entry, • suit ergonomy optimisation, • display of operational information in alpha-numerical and graphical from, and • voice processing for operations and safety critical information. Concerning crew safety the major design features are: • a lower R-factor for emergency EVA operations thru incressed suit pressure, • zero prebreath conditions for normal operations, • visual and voice processing of all safety critical functions, and • an autonomous life support system to permit unrestricted operations around HERMES and the CFFL. The paper analyses crew safety and productivity criteria and describes how these features are being built into the design of the European Space Suit System.

  20. Test Operations Procedure (TOP) 10-2-022A Chemical Vapor and Aerosol System-Level Testing of Chemical/Biological Protective Suits

    Science.gov (United States)

    2013-12-16

    data, QA/quality control (QC) plans]. 3.1.2 Familiarization. a. Potential problem areas will be identified by reviewing previous records and results...also wear specified footwear , gloves, protective mask, and hood. e. Test operators will assist the TPs in obtaining correct closure of the suit at...Vernon Hills, Illinois); and Pureline II® (Dixon Industries , Charlotte, North Carolina). (4) The pressure inside each RTM while drawing air must not

  1. Technology Mediated Instruction and its Effect on Cognitive Scaffolding, motivation and Academic Performance in EFL Context

    Directory of Open Access Journals (Sweden)

    Sepideh Berenji

    2017-11-01

    Full Text Available Technology mediated learning brings together the users with shared interests. This method makes learners informally engaged in language learning. This study intended to investigate the effect of technology mediated instruction on cognitive scaffolding, academic performance and motivation. Employing a quasi-experimental research, 80 learners from two intact classes at Islamic Azad University, Osku Branch were selected as the experimental and control groups. Telegram as a tool was used in the experimental group, while the control group received traditional way of instruction. Critical ethnography approach was implemented to consider the amount of cognitive scaffolding. To measure the students’ motivational level in both groups, Course Interest Survey (CIS was administered at the end of the semester. The total average score for each group was calculated. To compare students’ academic achievement, their average scores in the final academic test were considered. An Independent samples t-test in was used to compare the mean scores. The results indicated that technology mediated learning brought about cognitive scaffolding and the students in the experimental group outperformed the control group in terms of motivation and academic achievement. The results of the study suggest that to bring about academically successful students, practitioners should use technology mediated instruction.

  2. 33 CFR 150.518 - What are the inspection requirements for work vests and immersion suits?

    Science.gov (United States)

    2010-07-01

    ... requirements for work vests and immersion suits? 150.518 Section 150.518 Navigation and Navigable Waters COAST... vests and immersion suits? (a) All work vests and immersion suits must be inspected by the owner or... a work vest or immersion suit is inspected and is in serviceable condition, then it may remain in...

  3. Mediation designs for tobacco prevention research

    Science.gov (United States)

    MacKinnon, David P.; Taborga, Marcia P.; Morgan-Lopez, Antonio A.

    2010-01-01

    This paper describes research designs and statistical analyses to investigate how tobacco prevention programs achieve their effects on tobacco use. A theoretical approach to program development and evaluation useful for any prevention program guides the analysis. The theoretical approach focuses on action theory for how the program affects mediating variables and on conceptual theory for how mediating variables are related to tobacco use. Information on the mediating mechanisms by which tobacco prevention programs achieve effects is useful for the development of efficient programs and provides a test of the theoretical basis of prevention efforts. Examples of these potential mediating mechanisms are described including mediated effects through attitudes, social norms, beliefs about positive consequences, and accessibility to tobacco. Prior research provides evidence that changes in social norms are a critical mediating mechanism for successful tobacco prevention. Analysis of mediating variables in single group designs with multiple mediators are described as well as multiple group randomized designs which are the most likely to accurately uncover important mediating mechanisms. More complicated dismantling and constructive designs are described and illustrated based on current findings from tobacco research. Mediation analysis for categorical outcomes and more complicated statistical methods are outlined. PMID:12324176

  4. FusionCharts Beginner's Guide The Official Guide for FusionCharts Suite

    CERN Document Server

    Nadhani, Sanket; Bhattacharya, Shamasis

    2012-01-01

    The book is written as a practical, step-by-step guide to using FusionCharts Suite. The book not only teaches you the fundamentals and implementation of FusionCharts Suite, but also makes you the data visualization guru among your friends and colleagues by teaching how to select the right chart type and usability tips. Filled with examples, code samples and practical tips in a no-nonsense way, the book is a breeze to read.This book is both for beginners and advanced web developers who need to create interactive charts for their web applications. No previous knowledge of FusionCharts Suite is a

  5. Does job strain mediate the effect of socioeconomic group on smoking behaviour? The impact of different health policies in Denmark and Sweden

    DEFF Research Database (Denmark)

    Andersen, Ingelise; Rasmussen, Niels Kr; Ostergren, P O

    2008-01-01

    AIMS: The aim was to compare the impact of socioeconomic groups (SEG) on the risk of being a daily smoker or quitter, and to investigate whether the potentially mediating effect of psychosocial working conditions was similar in the Danish and the Swedish populations. METHODS: The study populations....... The association between SEG, current smoking, quitting, and influence at work, job demand and jobstrain, respectively, was tested by means of logistic regression. RESULTS: The contextual determinants defined by country had a different effect on smoking prevalence among men and women and among age groups. Low...... and more socially skewed among the Swedes, but did not mediate the effect of SEG on smoking behaviour. CONCLUSIONS: The smoking prevalence was lower and the quit-rates higher among Swedes than Danes. Both countries had social differences in smoking that in absolute terms were rather similar...

  6. Prokofiev. "Romeo and Juliet" - Suites / Iran March

    Index Scriptorium Estoniae

    March, Iran

    1991-01-01

    Uuest heliplaadist "Prokofiev. "Romeo and Juliet" - Suites: N 1 Op. 64 bis a; N 2 Op. 64 ter b; N 3 Op. 101 c. Royal Scottish National Orchestra /Neeme Järvi" Chandos cassette ABTD 1536; CD CHAN 8940 (78 minutes) etc

  7. Investigating the Group-Level Impact of Advanced Dual-Echo fMRI Combinations

    Directory of Open Access Journals (Sweden)

    Adam Kettinger

    2016-12-01

    Full Text Available Multi-echo fMRI data acquisition has been widely investigated and suggested to optimize sensitivity for detecting the BOLD signal. Several methods have also been proposed for the combination of data with different echo times. The aim of the present study was to investigate how these advance echo combination methods provide advantages over the simple averaging of echoes when state-of-the-art group-level random-effect analyses are performed. Both resting-state and task-based dual-echo fMRI data were collected from 27 healthy adult individuals (14 male, mean age = 25.75 years using standard echo-planar acquisition methods at 3T. Both resting-state and task-based data were subjected to a standard image pre-processing pipeline. Subsequently the two echoes were combined as a weighted average, using four different strategies for calculating the weights: (1 simple arithmetic averaging, (2 BOLD sensitivity weighting, (3 temporal-signal-to-noise ratio weighting and (4 temporal BOLD sensitivity weighting. Our results clearly show that the simple averaging of data with the different echoes is sufficient. Advanced echo combination methods may provide advantages on a single-subject level but when considering random-effects group level statistics they provide no benefit regarding sensitivity (i.e. group-level t-values compared to the simple echo-averaging approach. One possible reason for the lack of clear advantages may be that apart from increasing the average BOLD sensitivity at the single-subject level, the advanced weighted averaging methods also inflate the inter-subject variance. As the echo combination methods provide very similar results, the recommendation is to choose between them depending on the availability of time for collecting additional resting-state data or whether subject-level or group-level analyses are planned.

  8. A comparison of two Shuttle launch and entry suits - Reach envelope, isokinetic strength, and treadmill tests

    Science.gov (United States)

    Schafer, Lauren E.; Rajulu, Sudhakar L.; Klute, Glenn K.

    1992-01-01

    A quantification has been conducted of any existing differences between the performance, in operational conditions, of the Space Shuttle crew Launch Entry Suit (LES) and the new Advanced Crew Escape Suit (ACES). While LES is a partial-pressure suit, the ACES system which is being considered as a replacement for LES is a full-pressure suit. Three tests have been conducted with six subjects to ascertain the suits' reach envelope, strength, and treadmill performance. No significant operational differences were found between the two suit designs.

  9. Group-Level Organizational Citizenship Behavior in the Education System: A Scale Reconstruction and Validation

    Science.gov (United States)

    Vigoda-Gadot, Eran; Beeri, Itai; Birman-Shemesh, Taly; Somech, Anit

    2007-01-01

    Purpose: Most writings on Organizational Citizenship Behavior (OCB) to date have focused on analysis at the individual level and paid less attention to other analytical frameworks at the group level (i.e., team, unit, or organization). This article approaches OCB from the less conventional perspective of group-level activities and uses it to…

  10. A Parametric Model of Shoulder Articulation for Virtual Assessment of Space Suit Fit

    Science.gov (United States)

    Kim, K. Han; Young, Karen S.; Bernal, Yaritza; Boppana, Abhishektha; Vu, Linh Q.; Benson, Elizabeth A.; Jarvis, Sarah; Rajulu, Sudhakar L.

    2016-01-01

    Suboptimal suit fit is a known risk factor for crewmember shoulder injury. Suit fit assessment is however prohibitively time consuming and cannot be generalized across wide variations of body shapes and poses. In this work, we have developed a new design tool based on the statistical analysis of body shape scans. This tool is aimed at predicting the skin deformation and shape variations for any body size and shoulder pose for a target population. This new process, when incorporated with CAD software, will enable virtual suit fit assessments, predictively quantifying the contact volume, and clearance between the suit and body surface at reduced time and cost.

  11. A Pattern Language for Designing Application-Level Communication Protocols and the Improvement of Computer Science Education through Cloud Computing

    OpenAIRE

    Lascano, Jorge Edison

    2017-01-01

    Networking protocols have been developed throughout time following layered architectures such as the Open Systems Interconnection model and the Internet model. These protocols are grouped in the Internet protocol suite. Most developers do not deal with low-level protocols, instead they design application-level protocols on top of the low-level protocol. Although each application-level protocol is different, there is commonality among them and developers can apply lessons learned from one prot...

  12. An introduction to the theory of groups

    CERN Document Server

    Alexandroff, Paul; Petersen, GM

    2012-01-01

    This introductory exposition of group theory by an eminent Russian mathematician is particularly suited to undergraduates. Includes a wealth of simple examples, primarily geometrical, and end-of-chapter exercises. 1959 edition.

  13. Secondary mediation and regression analyses of the PTClinResNet database: determining causal relationships among the International Classification of Functioning, Disability and Health levels for four physical therapy intervention trials.

    Science.gov (United States)

    Mulroy, Sara J; Winstein, Carolee J; Kulig, Kornelia; Beneck, George J; Fowler, Eileen G; DeMuth, Sharon K; Sullivan, Katherine J; Brown, David A; Lane, Christianne J

    2011-12-01

    Each of the 4 randomized clinical trials (RCTs) hosted by the Physical Therapy Clinical Research Network (PTClinResNet) targeted a different disability group (low back disorder in the Muscle-Specific Strength Training Effectiveness After Lumbar Microdiskectomy [MUSSEL] trial, chronic spinal cord injury in the Strengthening and Optimal Movements for Painful Shoulders in Chronic Spinal Cord Injury [STOMPS] trial, adult stroke in the Strength Training Effectiveness Post-Stroke [STEPS] trial, and pediatric cerebral palsy in the Pediatric Endurance and Limb Strengthening [PEDALS] trial for children with spastic diplegic cerebral palsy) and tested the effectiveness of a muscle-specific or functional activity-based intervention on primary outcomes that captured pain (STOMPS, MUSSEL) or locomotor function (STEPS, PEDALS). The focus of these secondary analyses was to determine causal relationships among outcomes across levels of the International Classification of Functioning, Disability and Health (ICF) framework for the 4 RCTs. With the database from PTClinResNet, we used 2 separate secondary statistical approaches-mediation analysis for the MUSSEL and STOMPS trials and regression analysis for the STEPS and PEDALS trials-to test relationships among muscle performance, primary outcomes (pain related and locomotor related), activity and participation measures, and overall quality of life. Predictive models were stronger for the 2 studies with pain-related primary outcomes. Change in muscle performance mediated or predicted reductions in pain for the MUSSEL and STOMPS trials and, to some extent, walking speed for the STEPS trial. Changes in primary outcome variables were significantly related to changes in activity and participation variables for all 4 trials. Improvement in activity and participation outcomes mediated or predicted increases in overall quality of life for the 3 trials with adult populations. Variables included in the statistical models were limited to those

  14. A comparison of suit dresses and summer clothes in the terms of thermal comfort.

    Science.gov (United States)

    Ekici, Can; Atilgan, Ibrahim

    2013-12-19

    Fanger's PMV equation is the result of the combined quantitative effects of the air temperature, mean radiant temperature, relative air velocity, humidity, activity level and clothing insulation. This paper contains a comparison of suit dresses and summer clothes in terms of thermal comfort, Fanger's PMV equation. Studies were processed in the winter for an office, which locates in Ankara, Turkey. The office was partitioned to fifty square cells. Humidity, relative air velocity, air temperature and mean radiant temperature were measured on the centre points of these cells. Thermal comfort analyses were processed for suit dressing (Icl = 1 clo) and summer clothing (Icl = 0.5 clo). Discomfort/comfort in an environment for different clothing types can be seen in this study. The relationship between indoor thermal comfort distribution and clothing type was discussed. Graphics about thermal comfort were sketched according to cells. Conclusions about the thermal comfort of occupants were given by PMV graphics.

  15. Human Peripheral Blood Mononuclear Cells Exhibit Heterogeneous CD52 Expression Levels and Show Differential Sensitivity to Alemtuzumab Mediated Cytolysis

    Science.gov (United States)

    Rao, Sambasiva P.; Sancho, Jose; Campos-Rivera, Juanita; Boutin, Paula M.; Severy, Peter B.; Weeden, Timothy; Shankara, Srinivas; Roberts, Bruce L.; Kaplan, Johanne M.

    2012-01-01

    Alemtuzumab is a monoclonal antibody that targets cell surface CD52 and is effective in depleting lymphocytes by cytolytic effects in vivo. Although the cytolytic effects of alemtuzumab are dependent on the density of CD52 antigen on cells, there is scant information regarding the expression levels of CD52 on different cell types. In this study, CD52 expression was assessed on phenotypically distinct subsets of lymphoid and myeloid cells in peripheral blood mononuclear cells (PBMCs) from normal donors. Results demonstrate that subsets of PBMCs express differing levels of CD52. Quantitative analysis showed that memory B cells and myeloid dendritic cells (mDCs) display the highest number while natural killer (NK) cells, plasmacytoid dendritic cells (pDCs) and basophils have the lowest number of CD52 molecules per cell amongst lymphoid and myeloid cell populations respectively. Results of complement dependent cytolysis (CDC) studies indicated that alemtuzumab mediated profound cytolytic effects on B and T cells with minimal effect on NK cells, basophils and pDCs, correlating with the density of CD52 on these cells. Interestingly, despite high CD52 levels, mDCs and monocytes were less susceptible to alemtuzumab-mediated CDC indicating that antigen density alone does not define susceptibility. Additional studies indicated that higher expression levels of complement inhibitory proteins (CIPs) on these cells partially contributes to their resistance to alemtuzumab mediated CDC. These results indicate that alemtuzumab is most effective in depleting cells of the adaptive immune system while leaving innate immune cells relatively intact. PMID:22761788

  16. Human peripheral blood mononuclear cells exhibit heterogeneous CD52 expression levels and show differential sensitivity to alemtuzumab mediated cytolysis.

    Directory of Open Access Journals (Sweden)

    Sambasiva P Rao

    Full Text Available Alemtuzumab is a monoclonal antibody that targets cell surface CD52 and is effective in depleting lymphocytes by cytolytic effects in vivo. Although the cytolytic effects of alemtuzumab are dependent on the density of CD52 antigen on cells, there is scant information regarding the expression levels of CD52 on different cell types. In this study, CD52 expression was assessed on phenotypically distinct subsets of lymphoid and myeloid cells in peripheral blood mononuclear cells (PBMCs from normal donors. Results demonstrate that subsets of PBMCs express differing levels of CD52. Quantitative analysis showed that memory B cells and myeloid dendritic cells (mDCs display the highest number while natural killer (NK cells, plasmacytoid dendritic cells (pDCs and basophils have the lowest number of CD52 molecules per cell amongst lymphoid and myeloid cell populations respectively. Results of complement dependent cytolysis (CDC studies indicated that alemtuzumab mediated profound cytolytic effects on B and T cells with minimal effect on NK cells, basophils and pDCs, correlating with the density of CD52 on these cells. Interestingly, despite high CD52 levels, mDCs and monocytes were less susceptible to alemtuzumab-mediated CDC indicating that antigen density alone does not define susceptibility. Additional studies indicated that higher expression levels of complement inhibitory proteins (CIPs on these cells partially contributes to their resistance to alemtuzumab mediated CDC. These results indicate that alemtuzumab is most effective in depleting cells of the adaptive immune system while leaving innate immune cells relatively intact.

  17. Serum inflammatory mediators as markers of human Lyme disease activity.

    Directory of Open Access Journals (Sweden)

    Mark J Soloski

    Full Text Available Chemokines and cytokines are key signaling molecules that orchestrate the trafficking of immune cells, direct them to sites of tissue injury and inflammation and modulate their states of activation and effector cell function. We have measured, using a multiplex-based approach, the levels of 58 immune mediators and 7 acute phase markers in sera derived from of a cohort of patients diagnosed with acute Lyme disease and matched controls. This analysis identified a cytokine signature associated with the early stages of infection and allowed us to identify two subsets (mediator-high and mediator-low of acute Lyme patients with distinct cytokine signatures that also differed significantly (p<0.0005 in symptom presentation. In particular, the T cell chemokines CXCL9 (MIG, CXCL10 (IP-10 and CCL19 (MIP3B were coordinately increased in the mediator-high group and levels of these chemokines could be associated with seroconversion status and elevated liver function tests (p = 0.027 and p = 0.021 respectively. There was also upregulation of acute phase proteins including CRP and serum amyloid A. Consistent with the role of CXCL9/CXCL10 in attracting immune cells to the site of infection, CXCR3+ CD4 T cells are reduced in the blood of early acute Lyme disease (p = 0.01 and the decrease correlates with chemokine levels (p = 0.0375. The levels of CXCL9/10 did not relate to the size or number of skin lesions but elevated levels of serum CXCL9/CXCL10 were associated with elevated liver enzymes levels. Collectively these results indicate that the levels of serum chemokines and the levels of expression of their respective chemokine receptors on T cell subsets may prove to be informative biomarkers for Lyme disease and related to specific disease manifestations.

  18. Enhancements to the opera-3d suite

    International Nuclear Information System (INIS)

    Riley, C.P.

    1997-01-01

    The OPERA-3D suite of programs has been enhanced to include 2 additional 3 dimensional finite element based solvers, with complimentary features in the pre- and postprocessing. SOPRANO computes electromagnetic fields at high frequency including displacement current effects. It has 2 modules emdash a deterministic solution at a user defined frequency and an eigenvalue solution for modal analysis. It is suitable for designing microwave structures and cavities found in particle accelerators. SCALA computes electrostatic fields in the presence of space charge from charged particle beams. The user may define the emission characteristics of electrodes or plasma surfaces and compute the resultant space charge limited beams, including the presence of magnetic fields. Typical applications in particle accelerators are electron guns and ion sources. Other enhancements to the suite include additional capabilities in TOSCA and ELEKTRA, the static and dynamic solvers. copyright 1997 American Institute of Physics

  19. The Sample Analysis at Mars Investigation and Instrument Suite

    Science.gov (United States)

    Mahaffy, Paul; Webster, Christopher R.; Conrad, Pamela G.; Arvey, Robert; Bleacher, Lora; Brinckerhoff, William B.; Eigenbrode, Jennifer L.; Chalmers, Robert A.; Dworkin, Jason P.; Errigo, Therese; hide

    2012-01-01

    The Sample Analysis at Mars (SAM) investigation of the Mars Science Laboratory (MSL) addresses the chemical and isotopic composition of the atmosphere and volatiles extracted from solid samples. The SAM investigation is designed to contribute substantially to the mission goal of quantitatively assessing the habitability of Mars as an essential step in the search for past or present life on Mars. SAM is a 40 kg instrument suite located in the interior of MSL's Curiosity rover. The SAM instruments are a quadrupole mass spectrometer, a tunable laser spectrometer, and a 6-column gas chromatograph all coupled through solid and gas processing systems to provide complementary information on the same samples. The SAM suite is able to measure a suite of light isotopes and to analyze volatiles directly from the atmosphere or thermally released from solid samples. In addition to measurements of simple inorganic compounds and noble gases SAM will conduct a sensitive search for organic compounds with either thermal or chemical extraction from sieved samples delivered by the sample processing system on the Curiosity rover's robotic arm,

  20. Z-2 Space Suit: A Case Study in Human Spaceflight Public Outreach

    Science.gov (United States)

    McFarland, Shane M.

    2016-01-01

    NASA Johnson Space Center's Z-series of planetary space suit prototypes is an iterative development platform with a Mars-forward design philosophy, targeting a Mars surface mission in the mid-2030s. The first space suit assembly, called the Z-1, was delivered in 2012. While meeting the project's stated requirements and objectives, the general public's reception primarily focused on the color scheme, which vaguely invoked similarity to a certain animated cartoon character. The public at large has and continues to be exposed to varying space suit design aesthetics from popular culture and low TRL technology maturation efforts such as mechanical counterpressure. The lesson learned was that while the design aesthetic is not important from an engineering perspective, the perception of the public is important for NASA and human spaceflight in general. For the Z-2 space suit, an integrated public outreach strategy was employed to engage, excite and educate the public on the current technology of space suits and NASA's plans moving forward. The keystone of this strategy was a public vote on three different suit cover layer aesthetics, the winner of which would be used as inspiration in fabrication. Other components included social media, university collaboration, and select media appearances, the cumulative result of which, while intangible in its benefit, was ultimately a positive effect in terms of the image of NASA as well as the dissemination of information vital to dispelling public misconceptions.

  1. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder.

    Science.gov (United States)

    Spindola, Leticia Maria; Pan, Pedro Mario; Moretti, Patricia Natalia; Ota, Vanessa Kiyomi; Santoro, Marcos Leite; Cogo-Moreira, Hugo; Gadelha, Ary; Salum, Giovanni; Manfro, Gisele Gus; Mari, Jair Jesus; Brentani, Helena; Grassi-Oliveira, Rodrigo; Brietzke, Elisa; Miguel, Euripedes Constantino; Rohde, Luis Augusto; Sato, João Ricardo; Bressan, Rodrigo Affonseca; Belangero, Sintia Iole

    2017-09-01

    Investigating major depressive disorder (MDD) in childhood and adolescence can help reveal the relative contributions of genetic and environmental factors to MDD, since early stages of disease have less influence of illness exposure. Thus, we investigated the mRNA expression of 12 genes related to the hypothalamic-pituitary-adrenal (HPA) axis, inflammation, neurodevelopment and neurotransmission in the blood of children and adolescents with MDD and tested whether a history of childhood maltreatment (CM) affects MDD through gene expression. Whole-blood mRNA levels of 12 genes were compared among 20 children and adolescents with MDD diagnosis (MDD group), 49 participants without MDD diagnosis but with high levels of depressive symptoms (DS group), and 61 healthy controls (HC group). The differentially expressed genes were inserted in a mediation model in which CM, MDD, and gene expression were, respectively, the independent variable, outcome, and intermediary variable. NR3C1, TNF, TNFR1 and IL1B were expressed at significantly lower levels in the MDD group than in the other groups. CM history did not exert a significant direct effect on MDD. However, an indirect effect of the aggregate expression of the 4 genes mediated the relationship between CM and MDD. In the largest study investigating gene expression in children with MDD, we demonstrated that NR3C1, TNF, TNFR1 and IL1B expression levels are related to MDD and conjunctly mediate the effect of CM history on the risk of developing MDD. This supports a role of glucocorticoids and inflammation as potential effectors of environmental stress in MDD. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Cerebrospinal fluid neopterin analysis in neuropediatric patients: establishment of a new cut off-value for the identification of inflammatory-immune mediated processes.

    Directory of Open Access Journals (Sweden)

    Marta Molero-Luis

    Full Text Available OBJECTIVE: A high level of cerebrospinal fluid (CSF neopterin is a marker of central nervous system inflammatory-immune mediated processes. We aimed to assess data from 606 neuropediatric patients, describing the clinical and biochemical features of those neurological disorders presenting CSF neopterin values above a new cut-off value that was defined in our laboratory. METHODS: To establish the new CSF neopterin cut-off value, we studied two groups of patients: Group 1 comprised 68 patients with meningoencephalitis, and Group 2 comprised 52 children with a confirmed peripheral infection and no central nervous system involvement. We studied 606 CSF samples from neuropediatric patients who were classified into 3 groups: genetic diagnosis (A, acquired/unknown etiologic neurologic diseases (B and inflammatory-immune mediated processes (C. RESULTS: The CSF neopterin cut-off value was 61 nmol/L. Out of 606 cases, 56 presented a CSF neopterin level above this value. Group C had significantly higher CSF neopterin, protein and leukocyte values than the other groups. Sixteen of twenty-three patients in this group had a CSF neopterin level above the cut-off, whereas three and seven patients presented increased leukocyte and protein values, respectively. A significant association was found among CSF neopterin, proteins and leukocytes in the 606 patients. White matter disturbances were associated with high CSF neopterin concentrations. CONCLUSIONS: Although children with inflammatory-immune mediated processes presented higher CSF neopterin values, patients with other neurological disorders also showed increased CSF neopterin concentrations. These results stress the importance of CSF neopterin analysis for the identification of inflammatory-immune mediated processes.

  3. Relationships among identity, perceived discrimination, and depressive symptoms in eight ethnic-generational groups.

    Science.gov (United States)

    Donovan, Roxanne A; Huynh, Que-Lam; Park, Irene J K; Kim, Su Yeong; Lee, Richard M; Robertson, Emily

    2013-04-01

    Examine whether personal identity confusion and ethnic identity, respectively, moderate and/or mediate the relationship between perceived discrimination (PD) and depressive symptoms (DS) in eight ethnic-generational groups. The sample consisted of 9665 students (73% women; mean age 20.31) from 30 colleges and universities from around the United States. Cross-sectional data were gathered through a confidential online survey. Across groups, PD and ethnic identity levels varied, while identity confusion levels were mostly similar. Neither identity confusion nor ethnic identity moderated the PD-DS relationship for any groups. However, identity confusion was a partial mediator for immigrant and nonimmigrant Hispanic/Latino(a) and White/European American participants. Identity confusion also suppressed the PD-DS relationship for Black/African American participants. Results highlight the need for additional research on identity confusion's role in the PD-distress link and the importance of addressing ethnicity and generation status when examining the effects of PD on college students' mental health. © 2012 Wiley Periodicals, Inc.

  4. Diabetes Support Groups Improve Patient’s Compliance and Control Blood Glucose Levels

    Directory of Open Access Journals (Sweden)

    Zamrotul Izzah

    2013-09-01

    Full Text Available Providing information is not enough to improve diabetic patient’s compliance and achieve goals of therapy. Patient’s good awareness as well as emotional and social supports from family and community may play an important role to improve their compliance and clinical outcomes. Therefore, diabetes support groups were developed and each support group consisted of two pharmacists, two nurses, diabetic patients and their family members. A total of 70 type 2 diabetic patient’s were enrolled and randomized into support group 1 and support group 2. Patients in the group 1 received information leaflets only, while patient in the group 2 received pharmacist counselling and information leaflets at each meeting. Patient’s awareness of diabetes and compliance with medications were assessed by a short questionnaire at baseline and final follow-up. Blood glucose and cholesterol levels were also evaluated in both groups. At the end of study, the overall patient’s awareness and compliance improved by 61.5%. The random and fasting blood glucose levels decreased over than 30% in the group 2 and around 14% in the group 1. This study reveals that collaboration between health care professionals and community in the diabetes support group might help diabetic patients to increase their knowledge and compliance with the diabetes therapy as well as glycaemic control.

  5. The use of antigravity suits in the treatment of idiopathic orthostatic hypotension

    Science.gov (United States)

    Landmark, K.; Kravik, S.

    1980-01-01

    Idiopathic orthostatic hypotension is an uncommon disease characterized by a drop in blood pressure when going from a recumbent to a standing position. Treatment by medication generally produces poor results. Three patients at the Royal Hospital in Oslo were treated with antigravity suits and all were able to maintain adequate blood pressures in the standing position. One patient improved dramatically and was able to take short walks while wearing the suit. The two other patients, however, felt that wearing the suits eventually became uncomfortable. This treatment represents a useful treatment alternative for intractable cases.

  6. Controlatron Neutron Tube Test Suite Software Manual - Operation Manual (V2.2)

    CERN Document Server

    Noel, W P; Hertrich, R J; Martinez, M L; Wallace, D L

    2002-01-01

    The Controlatron Software Suite is a custom built application to perform automated testing of Controlatron neutron tubes. The software package was designed to allowing users to design tests and to run a series of test suites on a tube. The data is output to ASCII files of a pre-defined format for data analysis and viewing with the Controlatron Data Viewer Application. This manual discusses the operation of the Controlatron Test Suite Software and a brief discussion of state machine theory, as state machine is the functional basis of the software.

  7. Charnockites and granites of the western Adirondacks, New York, USA: a differentiated A-type suite

    Science.gov (United States)

    Whitney, P.R.

    1992-01-01

    Granitic rocks in the west-central Adirondack Highlands of New York State include both relatively homogeneous charnockitic and hornblende granitic gneisses (CG), that occur in thick stratiform bodies and elliptical domes, and heterogeneous leucogneisses (LG), that commonly are interlayered with metasedimentary rocks. Major- and trace-element geochemical analyses were obtained for 115 samples, including both types of granitoids. Data for CG fail to show the presence of more than one distinct group based on composition. Most of the variance within the CG sample population is consistent with magmatic differentiation combined with incomplete separation of early crystals of alkali feldspar, plagioclase, and pyroxenes or amphibole from the residual liquid. Ti, Fe, Mg, Ca, P, Sr, Ba, and Zr decrease with increasing silica, while Rb and K increase. Within CG, the distinction between charnockitic (orthopyroxene-bearing) and granitic gneisses is correlated with bulk chemistry. The charnockites are consistently more mafic than the hornblende granitic gneisses, although forming a continuum with them. The leucogneisses, while generally more felsic than the charnockites and granitic gneisses, are otherwise geochemically similar to them. The data are consistent with the LG suite being an evolved extrusive equivalent of the intrusive CG suite. Both CG and LG suites are metaluminous to mildly peraluminous and display an A-type geochemical signature, enriched in Fe, K, Ce, Y, Nb, Zr, and Ga and depleted in Ca, Mg, and Sr relative to I- and S-type granites. Rare earth element patterns show moderate LREE enrichment and a negative Eu anomaly throughout the suite. The geochemical data suggest an origin by partial melting of biotite- and plagioclase-rich crustal rocks. Emplacement occurred in an anorogenic or post-collisional tectonic setting, probably at relatively shallow depths. Deformation and granulite-facies metamorphism with some partial melting followed during the Ottawan phase

  8. Equation-of-State Test Suite for the DYNA3D Code

    Energy Technology Data Exchange (ETDEWEB)

    Benjamin, Russell D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-11-05

    This document describes the creation and implementation of a test suite for the Equationof- State models in the DYNA3D code. A customized input deck has been created for each model, as well as a script that extracts the relevant data from the high-speed edit file created by DYNA3D. Each equation-of-state model is broken apart and individual elements of the model are tested, as well as testing the entire model. The input deck for each model is described and the results of the tests are discussed. The intent of this work is to add this test suite to the validation suite presently used for DYNA3D.

  9. Non-Venting Thermal and Humidity Control for EVA Suits

    Science.gov (United States)

    Izenson, Mike; Chen, Weibo; Bue, Grant

    2011-01-01

    Future EVA suits need processes and systems to control internal temperature and humidity without venting water to the environment. This paper describes an absorption-based cooling and dehumidification system as well as laboratory demonstrations of the key processes. There are two main components in the system: an evaporation cooling and dehumidification garment (ECDG) that removes both sensible heat and latent heat from the pressure garment, and an absorber radiator that absorbs moisture and rejects heat to space by thermal radiation. This paper discusses the overall design of both components, and presents recent data demonstrating their operation. We developed a design and fabrication approach to produce prototypical heat/water absorbing elements for the ECDG, and demonstrated by test that these elements could absorb heat and moisture at a high flux. Proof-of-concept tests showed that an ECDG prototype absorbs heat and moisture at a rate of 85 W/ft under conditions that simulate operation in an EVA suit. The heat absorption was primarily due to direct absorption of water vapor. It is possible to construct large, flexible, durable cooling patches that can be incorporated into a cooling garment with this system. The proof-of-concept test data was scaled to calculate area needed for full metabolic loads, thus showing that it is feasible to use this technology in an EVA suit. Full-scale, lightweight absorber/radiator modules have also been built and tested. They can reject heat at a flux of 33 W/ft while maintaining ECDG operation at conditions that will provide a cool and dry environment inside the EVA suit.

  10. Compression under a mechanical counter pressure space suit glove

    Science.gov (United States)

    Waldie, James M A.; Tanaka, Kunihiko; Tourbier, Dietmar; Webb, Paul; Jarvis, Christine W.; Hargens, Alan R.

    2002-01-01

    Background: Current gas-pressurized space suits are bulky stiff shells severely limiting astronaut function and capability. A mechanical counter pressure (MCP) space suit in the form of a tight elastic garment could dramatically improve extravehicular activity (EVA) dexterity, but also be advantageous in safety, cost, mass and volume. The purpose of this study was to verify that a prototype MCP glove exerts the design compression of 200 mmHg, a pressure similar to the current NASA EVA suit. Methods: Seven male subjects donned a pressure measurement array and MCP glove on the right hand, which was placed into a partial vacuum chamber. Average compression was recorded on the palm, the bottom of the middle finger, the top of the middle finger and the dorsum of the hand at pressures of 760 (ambient), 660 and 580 mmHg. The vacuum chamber was used to simulate the pressure difference between the low breathing pressure of the current NASA space suits (approximately 200 mmHg) and an unprotected hand in space. Results: At ambient conditions, the MCP glove compressed the dorsum of the hand at 203.5 +/- 22.7 mmHg, the bottom of the middle finger at 179.4 +/- 16.0 mmHg, and the top of the middle finger at 183.8 +/- 22.6 mmHg. The palm compression was significantly lower (59.6 +/- 18.8 mmHg, pglove compression with the chamber pressure reductions. Conclusions: The MCP glove compressed the dorsum of the hand and middle finger at the design pressure.

  11. A Suite of Tools for Technology Assessment

    Science.gov (United States)

    2007-09-01

    Saden, Povinelli & Rosen, 1989). • This was a significant change in emphasis on the part of NASA, where technology had previously viewed as merely...Cost Analysis Symposium, April 13, 2005. A Suite of Tools for Technology Assessment 24 Bibliography - continued: • Sadin, Stanley T.; Povinelli

  12. Effects of Baicalin on inflammatory mediators and pancreatic acinar cell apoptosis in rats with sever acute pancreatitis

    Directory of Open Access Journals (Sweden)

    zhang xiping

    2009-02-01

    Full Text Available

    • BACKGROUND: To investigate the effects of Baicalin and Octreotide on inflammatory mediators and pancreatic acinar cells apoptosis of rats with severe acute pancreatitis (SAP.
    • METHODS: SD rats were randomly divided into sham operated group (I group, model control group (II group, Baicalin treated group (III group and Octreotide treated group (IV group. Each group was also divided into subgroup of 3, 6 and 12 h (n = 15. The mortality rate, ascites/body weight ratio as well as the level of endotoxin, NO and ET-1 in blood were measured. The pathological severity score of pancreas, apoptotic indexes, and expression levels of Bax and Bcl-2 proteins in each group were investigated.
    • RESULTS: The survival rate of III and IV group has a significant difference compared with II group (P12 h < 0.05. The ascites volume, contents of inflammatory mediators in blood and pathological severity score of pancreas of III and IV group declined at different degrees compared to II group (P < 0.05, P < 0.01 or P < 0.001. Apoptotic index in III group was significantly higher than that in II group at 3 and 6 h (P3, 6 h < 0.05. Apoptotic index in IV group was significantly higher than that in II group at pancreatic tail at 6 h (P6 h < 0.05. Expression level of Bax in III group was significantly higher than that in II group (pancreatic head P3 h,6 h < 0.01, pancreatic tail P3 h < 0.001.
    • CONCLUSIONS: Compared with Octreotide in the treatment of SAP, the protective mechanisms of Baicalin include reducing the excessive inflammatory mediators’ release, inducing the pancreatic acinar cells apoptosis.
    • KEY WORDS: Severe acute pancreatitis, baicalin, octreotide, inflammatory mediators, apoptosis, tissue microarrays.

  13. Salivary TNFα levels in groups of subjects with rheumatoid arthritis and chronic periodontitis.

    Science.gov (United States)

    Gamel, Ehsan B; Hashim, Nada T; Satti, Asim; Gismalla, Bakri G

    2017-01-07

    Rheumatoid arthritis (RA) and chronic periodontitis are the most common chronic inflammatory diseases with significant pathological and clinical similarities. Numerous studies have indicated a relationship between rheumatoid arthritis and periodontal disease. The aim of this study was to compare the TNF-α levels in saliva among patients with Rheumatoid arthritis (RA) and chronic periodontitis as well as healthy subjects. One hundred and seventy-one patients were enrolled in this cross-sectional study. Fifty-seven patients diagnosed of RA, 57 patients with chronic periodontitis and 57 healthy subjects. These patients have been examined with regard to TNF-α level from salivary samples. Their teeth were examined with regard to Plaque Index , Gingival Index, probing depth and clinical attachment level.All patients were non-smokers. The results revealed a significant difference in all periodontal parameters among the three groups. The chronic periodontitis group showed a significantly higher value in all clinical periodontal parameters in comparison to both the RA and healthy groups. No significant difference was found between salivary TNF-α level among the three study groups. Patients with chronic periodontitis had the highest periodontal indices. However there was no significant difference regarding the level of salivary TNF-α. Hence, suppression of proinflammatory cytokines might prove beneficial in suppressing periodontal diseases among RA patients.

  14. Social skills training and play group intervention for children with oppositional-defiant disorders/conduct disorder: Mediating mechanisms in a head-to-head comparison.

    Science.gov (United States)

    Katzmann, Josepha; Goertz-Dorten, Anja; Hautmann, Christopher; Doepfner, Manfred

    2018-01-19

    Social-cognitive information processing, social skills, and social interactions are problem-maintaining variables for aggressive behavior in children. We hypothesized that these factors may be possible mediators of the mechanism of change in the child-centered treatment of conduct disorders (CDs). The aim of the present study (Clinical trials.gov Identifier: NCT01406067) was to examine putative mechanisms of change for the decrease in oppositional-defiant behavior resulting from child-centered treatment of patients with oppositional-defiant disorder (ODD) or CD. 91 children (age 6-12 years) with ODD/CD were randomized to receive either social skills training or to a resource activating play group. Mediator analyses were conducted using path analyses. The assumed mediating effects were not significant. However, alternative models with the putative mediators and outcome in reversed positions showed significant indirect effects of the oppositional-defiant symptoms as mediator for the decrease of disturbance of social-information processing, social skills, and social interactions. The proposed model for mechanisms of change could not be confirmed, with the results pointing to a reversed causality. Variables other than those hypothesized must be responsible for mediating the effects of the intervention on child oppositional-defiant behavior. Possible mechanisms of change were discussed.

  15. [Updates on rickets and osteomalacia: FGF23-mediated hypophosphatemic rickets/osteomalacia].

    Science.gov (United States)

    Michigami, Toshimi

    2013-10-01

    Some of the hypophosphatemic rickets/osteomalacia are caused by the increased bioactivity of FGF23, and classified into FGF23-mediated hypophosphatemic rickets/osteomalacia. This group includes various disorders such as X-linked, autosomal dominant and autosomal recessive hypophosphatemic rickets/osteomalacia, tumor-induced osteomalacia, and rickets/osteomalacia caused by the administration of iron polymaltose or saccharated ferric oxide. Measurement of serum levels of FGF23 is useful for diagnosis of these conditions. In the adult patients with FGF23-mediated hypophosphatemic rickets/osteomalacia, mineralizing enthesoopathy is an often observed complication.

  16. Comparing apples and oranges: the Community Intercomparison Suite

    Science.gov (United States)

    Schutgens, Nick; Stier, Philip; Kershaw, Philip; Pascoe, Stephen

    2015-04-01

    Visual representation and comparison of geoscientific datasets presents a huge challenge due to the large variety of file formats and spatio-temporal sampling of data (be they observations or simulations). The Community Intercomparison Suite attempts to greatly simplify these tasks for users by offering an intelligent but simple command line tool for visualisation and colocation of diverse datasets. In addition, CIS can subset and aggregate large datasets into smaller more manageable datasets. Our philosophy is to remove as much as possible the need for specialist knowledge by the user of the structure of a dataset. The colocation of observations with model data is as simple as: "cis col ::" which will resample the simulation data to the spatio-temporal sampling of the observations, contingent on a few user-defined options that specify a resampling kernel. As an example, we apply CIS to a case study of biomass burning aerosol from the Congo. Remote sensing observations, in-situe observations and model data are shown in various plots, with the purpose of either comparing different datasets or integrating them into a single comprehensive picture. CIS can deal with both gridded and ungridded datasets of 2, 3 or 4 spatio-temporal dimensions. It can handle different spatial coordinates (e.g. longitude or distance, altitude or pressure level). CIS supports both HDF, netCDF and ASCII file formats. The suite is written in Python with entirely publicly available open source dependencies. Plug-ins allow a high degree of user-moddability. A web-based developer hub includes a manual and simple examples. CIS is developed as open source code by a specialist IT company under supervision of scientists from the University of Oxford and the Centre of Environmental Data Archival as part of investment in the JASMIN superdatacluster facility.

  17. Mission Specialist Scott Parazynski checks his flight suit

    Science.gov (United States)

    1998-01-01

    STS-95 Mission Specialist Scott E. Parazynski gets help with his flight suit in the Operations and Checkout Building from a suit technician George Brittingham. The final fitting takes place prior to the crew walkout and transport to Launch Pad 39B. Targeted for launch at 2 p.m. EST on Oct. 29, the mission is expected to last 8 days, 21 hours and 49 minutes, and return to KSC at 11:49 a.m. EST on Nov. 7. The STS-95 mission includes research payloads such as the Spartan solar-observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process.

  18. STS-87 Mission Specialist Winston E. Scott suits up

    Science.gov (United States)

    1997-01-01

    STS-87 Mission Specialist Winston Scott dons his launch and entry suit with the assistance of a suit technician in the Operations and Checkout Building. This is Scotts second space flight. He and the five other crew members will depart shortly for Launch Pad 39B, where the Space Shuttle Columbia awaits liftoff on a 16-day mission to perform microgravity and solar research. Scott is scheduled to perform an extravehicular activity spacewalk with Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan, during STS-87. He also performed a spacewalk on STS-72.

  19. Culture and group-based emotions: could group-based emotions be dialectical?

    Science.gov (United States)

    Lu, Minjie; Hamamura, Takeshi; Doosje, Bertjan; Suzuki, Satoko; Takemura, Kosuke

    2017-08-01

    Group-based emotions are experienced when individuals are engaged in emotion-provoking events that implicate the in-group. This research examines the complexity of group-based emotions, specifically a concurrence of positive and negative emotions, focusing on the role of dialecticism, or a set of folk beliefs prevalent in Asian cultures that views nature and objects as constantly changing, inherently contradictory, and fundamentally interconnected. Study 1 found that dialecticism is positively associated with the complexity of Chinese participants' group-based emotions after reading a scenario depicting a positive intergroup experience. Study 2 found that Chinese participants experienced more complex group-based emotions compared with Dutch participants in an intergroup situation and that this cultural difference was mediated by dialecticism. Study 3 manipulated dialecticism and confirmed its causal effect on complex group-based emotions. These studies also suggested the role of a balanced appraisal of an intergroup situation as a mediating factor.

  20. Virtual Suit Fit Assessment Using Body Shape Model

    Data.gov (United States)

    National Aeronautics and Space Administration — Shoulder injury is one of the most serious risks for crewmembers in long-duration spaceflight. While suboptimal suit fit and contact pressures between the shoulder...

  1. Psychological Vulnerability and Problem Gambling: The Mediational Role of Cognitive Distortions.

    Science.gov (United States)

    Lévesque, David; Sévigny, Serge; Giroux, Isabelle; Jacques, Christian

    2018-01-03

    Despite numerous studies demonstrating the influence of cognitive distortions on gambling problem severity, empirical data regarding the role of psychological vulnerability on the latter is limited. Hence, this study assesses the mediating effect of cognitive distortions between psychological vulnerability (personality and mood), and gambling problem severity. It also verifies whether the relationships between these variables differs according to the preferred gambling activity. The sample is composed of 272 male gamblers [191 poker players; 81 video lottery terminal (VLT) players] aged between 18 and 82 years (M = 35.2). Bootstrap analysis results revealed that cognitive distortions mediate the effect of narcissism on gambling problem severity for both groups. The level of depression for VLT players significantly predicted gambling problem severity, both directly and indirectly via the mediating effect of cognitive distortions. Mediation analyses also indicated that narcissism had an indirect impact on problem gambling through cognitive distortions for both groups. These findings suggest that certain vulnerabilities related to personality and mood may influence cognitive distortion intensity and gambling problem severity. In addition, psychological vulnerabilities could differ based on preferred gambling activity. These results may be useful for prevention policies, identifying high risk gamblers and planning psychological interventions.

  2. A method of evaluating efficiency during space-suited work in a neutral buoyancy environment

    Science.gov (United States)

    Greenisen, Michael C.; West, Phillip; Newton, Frederick K.; Gilbert, John H.; Squires, William G.

    1991-01-01

    The purpose was to investigate efficiency as related to the work transmission and the metabolic cost of various extravehicular activity (EVA) tasks during simulated microgravity (whole body water immersion) using three space suits. Two new prototype space station suits, AX-5 and MKIII, are pressurized at 57.2 kPa and were tested concurrently with the operationally used 29.6 kPa shuttle suit. Four male astronauts were asked to perform a fatigue trial on four upper extremity exercises during which metabolic rate and work output were measured and efficiency was calculated in each suit. The activities were selected to simulate actual EVA tasks. The test article was an underwater dynamometry system to which the astronauts were secured by foot restraints. All metabolic data was acquired, calculated, and stored using a computerized indirect calorimetry system connected to the suit ventilation/gas supply control console. During the efficiency testing, steady state metabolic rate could be evaluated as well as work transmitted to the dynamometer. Mechanical efficiency could then be calculated for each astronaut in each suit performing each movement.

  3. Groups win pollution suit against Texaco

    International Nuclear Information System (INIS)

    Stern, P.

    1992-01-01

    The Natural Resources Defense Council (NRDC) and the Delaware Audubon Society have won a ruling in federal court against Texaco Refining and Marketing, Inc. for continuous pollution of the Delaware River. Texaco was found to have committed hundreds of violations under the Clean Water Act during a 9 year period from 1983 to 1991, and was ordered to pay a $1.68 million penalty. Texaco must also improve its water pollution investigation practices which were deemed inconsistent and less than thorough, relying on supposition rather than thorough investigation. A court order enjoining Texaco from further violations was deemed necessary to vindicate the public interest. Illegal discharges included chlorine, ammonia, and oil and grease, with some violations exceeding legal limits by as much as 2000%

  4. Same-level fall injuries in US workplaces by age group, gender, and industry.

    Science.gov (United States)

    Scott, Kenneth A; Fisher, Gwenith G; Barón, Anna E; Tompa, Emile; Stallones, Lorann; DiGuiseppi, Carolyn

    2018-02-01

    As the workforce ages, occupational injuries from falls on the same level will increase. Some industries may be more affected than others. We conducted a cross-sectional study using data from the Bureau of Labor Statistics to estimate same-level fall injury incidence rates by age group, gender, and industry for four sectors: 1) healthcare and social assistance; 2) manufacturing; 3) retail; and 4) transportation and warehousing. We calculated rate ratios and rate differences by age group and gender. Same-level fall injury incidence rates increase with age in all four sectors. However, patterns of rate ratios and rate differences vary by age group, gender, and industry. Younger workers, men, and manufacturing workers generally have lower rates. Variation in incidence rates suggests there are unrealized opportunities to prevent same-level fall injuries. Interventions should be evaluated for their effectiveness at reducing injuries, avoiding gender- or age-discrimination and improving work ability. © 2017 Wiley Periodicals, Inc.

  5. GHRSST Level 2P Global Sea Surface Temperature from the Visible Infrared Imaging Radiometer Suite (VIIRS) on the Suomi NPP satellite (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Visible and Infrared Imager/Radiometer Suite (VIIRS) is a multi-disciplinary instrument that is being flown on the Joint Polar Satellite System (JPSS) series of...

  6. Reconstruing intolerance: abstract thinking reduces conservatives' prejudice against nonnormative groups.

    Science.gov (United States)

    Luguri, Jamie B; Napier, Jaime L; Dovidio, John F

    2012-07-01

    Myrdal (1944) described the "American dilemma" as the conflict between abstract national values ("liberty and justice for all") and more concrete, everyday prejudices. We leveraged construal-level theory to empirically test Myrdal's proposition that construal level (abstract vs. concrete) can influence prejudice. We measured individual differences in construal level (Study 1) and manipulated construal level (Studies 2 and 3); across these three studies, we found that adopting an abstract mind-set heightened conservatives' tolerance for groups that are perceived as deviating from Judeo-Christian values (gay men, lesbians, Muslims, and atheists). Among participants who adopted a concrete mind-set, conservatives were less tolerant of these nonnormative groups than liberals were, but political orientation did not have a reliable effect on tolerance among participants who adopted an abstract mind-set. Attitudes toward racial out-groups and dominant groups (e.g., Whites, Christians) were unaffected by construal level. In Study 3, we found that the effect of abstract thinking on prejudice was mediated by an increase in concerns about fairness.

  7. Fluid replacement advice during work in fully encapsulated impermeable chemical protective suits

    NARCIS (Netherlands)

    Rubenstein, C.D.; Hartog, E.A. den; Deaton, A.S.; Bogerd, C.P.; Kant, S. de

    2017-01-01

    A major concern for responders to hazardous materials (HazMat) incidents is the heat strain that is caused by fully encapsulated impermeable chemical protective suits. In a research project, funded by the US Department of Defense, the thermal strain experienced when wearing these suits was studied.

  8. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2004-01-01

    Implementation of new computer-mediated communication (CMC) systems in organizations is a complex socio-technical endeavour, involving the mutual adaptation of technology and organization over time. Drawing on the analytic concept of sensemaking, this paper provides a theoretical perspective...... that deepens our understanding of how organizations appropriate new electronic communication media. The paper analyzes how a group of mediators in a large, multinational company adapted a new web-based CMC technology (a virtual workspace) to the local organizational context (and vice versa) by modifying...... features of the technology, providing ongoing support for users, and promoting appropriate conventions of use. We found that these mediators exerted considerable influence on how the technology was established and used in the organization. The mediators were not neutral facilitators of a well...

  9. Optimizing the physical ergonomics indices for the use of partial pressure suits.

    Science.gov (United States)

    Ding, Li; Li, Xianxue; Hedge, Alan; Hu, Huimin; Feathers, David; Qin, Zhifeng; Xiao, Huajun; Xue, Lihao; Zhou, Qianxiang

    2015-03-01

    This study developed an ergonomic evaluation system for the design of high-altitude partial pressure suits (PPSs). A total of twenty-one Chinese males participated in the experiment which tested three types of ergonomics indices (manipulative mission, operational reach and operational strength) were studied using a three-dimensional video-based motion capture system, a target-pointing board, a hand dynamometer, and a step-tread apparatus. In total, 36 ergonomics indices were evaluated and optimized using regression and fitting analysis. Some indices that were found to be linearly related and redundant were removed from the study. An optimal ergonomics index system was established that can be used to conveniently and quickly evaluate the performance of different pressurized/non-pressurized suit designs. The resulting ergonomics index system will provide a theoretical basis and practical guidance for mission planners, suit designers and engineers to design equipment for human use, and to aid in assessing partial pressure suits. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  10. Effect of fastskin suits on performance, drag, and energy cost of swimming.

    Science.gov (United States)

    Chatard, Jean-Claude; Wilson, Barry

    2008-06-01

    To investigate the effect of fastskin suits on 25- to 800-m performances, drag, and energy cost of swimming. The performances, stroke rate and distance per stroke, were measured for 14 competitive swimmers in a 25-m pool, when wearing a normal suit (N) and when wearing a full-body suit (FB) or a waist-to-ankle suit (L). Passive drag, oxygen uptake, blood lactate, and the perceived exertion were measured in a flume. There was a 3.2% +/- 2.4% performance benefit for all subjects over the six distances covered at maximal speed wearing FB and L when compared with N. When wearing L, the gain was significantly lower (1.8% +/- 2.5%, P energy cost of swimming was significantly reduced when wearing FB and L by 4.5% +/- 5.4% and 5.5% +/- 3.1%, respectively (P energy cost of submaximal swimming and an increased distance per stroke, at the same stroke rates, and reduced freestyle performance time.

  11. Carbon Dioxide Washout Testing Using Various Inlet Vent Configurations in the Mark-III Space Suit

    Science.gov (United States)

    Korona, F. Adam; Norcross, Jason; Conger, Bruce; Navarro, Moses

    2014-01-01

    Requirements for using a space suit during ground testing include providing adequate carbon dioxide (CO2) washout for the suited subject. Acute CO2 exposure can lead to symptoms including headache, dyspnea, lethargy, and eventually unconsciousness or even death. Symptoms depend on several factors including inspired partial pressure of CO2 (ppCO2), duration of exposure, metabolic rate of the subject, and physiological differences between subjects. Computational Fluid Dynamics (CFD) analysis has predicted that the configuration of the suit inlet vent has a significant effect on oronasal CO2 concentrations. The main objective of this test was to characterize inspired oronasal ppCO2 for a variety of inlet vent configurations in the Mark-III suit across a range of workload and flow rates. Data and trends observed during testing along with refined CFD models will be used to help design an inlet vent configuration for the Z-2 space suit. The testing methodology used in this test builds upon past CO2 washout testing performed on the Z-1 suit, Rear Entry I-Suit, and the Enhanced Mobility Advanced Crew Escape Suit. Three subjects performed two test sessions each in the Mark-III suit to allow for comparison between tests. Six different helmet inlet vent configurations were evaluated during each test session. Suit pressure was maintained at 4.3 psid. Suited test subjects walked on a treadmill to generate metabolic workloads of approximately 2000 and 3000 BTU/hr. Supply airflow rates of 6 and 4 actual cubic feet per minute were tested at each workload. Subjects wore an oronasal mask with an open port in front of the mouth and were allowed to breathe freely. Oronasal ppCO2 was monitored real-time via gas analyzers with sampling tubes connected to the oronasal mask. Metabolic rate was calculated from the CO2 production measured by an additional gas analyzer at the air outlet from the suit. Real-time metabolic rate measurements were used to adjust the treadmill workload to meet

  12. Radiation Protection Studies of International Space Station Extravehicular Activity Space Suits

    Science.gov (United States)

    Cucinotta, Francis A. (Editor); Shavers, Mark R. (Editor); Saganti, Premkumar B. (Editor); Miller, Jack (Editor)

    2003-01-01

    This publication describes recent investigations that evaluate radiation shielding characteristics of NASA's and the Russian Space Agency's space suits. The introduction describes the suits and presents goals of several experiments performed with them. The first chapter provides background information about the dynamic radiation environment experienced at ISS and summarized radiation health and protection requirements for activities in low Earth orbit. Supporting studies report the development and application of a computer model of the EMU space suit and the difficulty of shielding EVA crewmembers from high-energy reentrant electrons, a previously unevaluated component of the space radiation environment. Chapters 2 through 6 describe experiments that evaluate the space suits' radiation shielding characteristics. Chapter 7 describes a study of the potential radiological health impact on EVA crewmembers of two virtually unexamined environmental sources of high-energy electrons-reentrant trapped electrons and atmospheric albedo or "splash" electrons. The radiological consequences of those sources have not been evaluated previously and, under closer scrutiny. A detailed computational model of the shielding distribution provided by components of the NASA astronauts' EMU is being developed for exposure evaluation studies. The model is introduced in Chapters 8 and 9 and used in Chapter 10 to investigate how trapped particle anisotropy impacts female organ doses during EVA. Chapter 11 presents a review of issues related to estimating skin cancer risk form space radiation. The final chapter contains conclusions about the protective qualities of the suit brought to light form these studies, as well as recommendations for future operational radiation protection.

  13. U.S. Climate Normals Product Suite (1981-2010)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Climate Normals are a large suite of data products that provide users with many tools to understand typical climate conditions for thousands of locations...

  14. Aging of theory of mind: the influence of educational level and cognitive processing.

    Science.gov (United States)

    Li, Xiaoming; Wang, Kai; Wang, Fan; Tao, Qian; Xie, Yu; Cheng, Qi

    2013-01-01

    Previous studies of theory of mind (ToM) in old age have provided mixed results. We predicted that educational level and cognitive processing are two factors influencing the pattern of the aging of ToM. To test this hypothesis, a younger group who received higher education (mean age 20.46 years), an older group with an education level equal to that of the young group (mean age 76.29 years), and an older group with less education (mean age 73.52 years) were recruited. ToM tasks included the following tests: the second-order false-belief task, the faux-pas task, the eyes test, and tests of fundamental aspects of cognitive function that included two background tests (memory span and processing speed) and three subcomponents of executive function (inhibition, updating, and shifting). We found that the younger group and the older group with equally high education outperformed the older group with less education in false-belief and faux-pas tasks. However, there was no significant difference between the two former groups. The three groups of participants performed equivalently in the eyes test as well as in control tasks (false-belief control question, faux-pas control question, faux-pas control story, and Eyes Test control task). The younger group outperformed the other two groups in the cognitive processing tasks. Mediation analyses showed that difficulties in inhibition, memory span, and processing speed mediated the age differences in false-belief reasoning. Also, the variables of inhibition, updating, memory span, and processing speed mediated age-related variance in faux-pas. Discussion focused on the links between ToM aging, educational level, and cognitive processing. Supported by Chinese National Natural Science Foundation (number: 30870766) and Anhui Province Natural Science Foundation (number: 11040606M166).

  15. Association between IgE-mediated allergies and diabetes mellitus type 1 in children and adolescents.

    Science.gov (United States)

    Klamt, Sabine; Vogel, Mandy; Kapellen, Thomas M; Hiemisch, Andreas; Prenzel, Freerk; Zachariae, Silke; Ceglarek, Uta; Thiery, Joachim; Kiess, Wieland

    2015-11-01

    Type 1 diabetes mellitus (T1DM) is characterized by an immunological reaction that is dominated by type-1 T helper (Th1) cells, whereas immunoglobulin E (IgE)-mediated allergies are associated with Th2 cell. According to the Th1/Th2-hypothesis, the immune system is said to either develop into the direction of Th1 or Th2 cells. This would mean that a child developing T1DM is unlikely to develop an IgE-mediated allergy and vice versa. The aim of the study was to investigate the association between the prevalence of T1DM and IgE-mediated allergies. We designed a prospective case control study with 94 children and adolescents with T1DM and 188 age- and sex-matched control children. The basis of our investigations was a questionnaire concerning the family and children's history as to the presence of IgE-mediated allergies. Moreover, the following blood investigations were done: total serum IgE, specific IgE antibodies to major inhalant allergens, and a multiplex cytokine analysis measuring levels of specific cytokines representing either Th1- or Th2- cytokines. Children with T1DM reported the presence of IgE-mediated allergies significantly more often than children of the control group. Children with T1DM had significantly higher tumor necrosis factor alpha (TNFα) levels than healthy controls. Levels of interleukin-2 (IL-2) and IL-6 were higher in the groups of children with the presence of a personal history of allergies, regardless of the presence of T1DM. Our results suggest that T1DM is associated with a higher risk of a self-reported presence of IgE-mediated allergies and that the Th1/Th2-hypothesis may be an oversimplification. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Episodic intrusion, internal differentiation, and hydrothermal alteration of the miocene tatoosh intrusive suite south of Mount Rainier, Washington

    Science.gov (United States)

    du Bray, E.A.; Bacon, C.R.; John, D.A.; Wooden, J.L.; Mazdab, F.K.

    2011-01-01

    The Miocene Tatoosh intrusive suite south of Mount Rainier is composed of three broadly granodioritic plutons that are manifestations of ancestral Cascades arc magmatism. Tatoosh intrusive suite plutons have individually diagnostic characteristics, including texture, mineralogy, and geochemistry, and apparently lack internal contacts. New ion-microprobe U-Pb zircon ages indicate crystallization of the Stevens pluton ca. 19.2 Ma, Reflection-Pyramid pluton ca. 18.5 Ma, and Nisqually pluton ca. 17.5 Ma. The Stevens pluton includes rare, statistically distinct ca. 20.1 Ma zircon antecrysts. Wide-ranging zircon rare earth element (REE), Hf, U, and Th concentrations suggest late crystallization from variably evolved residual liquids. Zircon Eu/Eu*-Hf covariation is distinct for each of the Reflection-Pyramid, Nisqually, and Stevens plutons. Although most Tatoosh intrusive suite rocks have been affected by weak hydrothermal alteration, and sparse mineralized veins cut some of these rocks, significant base or precious metal mineralization is absent. At the time of shallow emplacement, each of these magma bodies was largely homogeneous in bulk composition and petrographic features, but, prior to final solidification, each of the Tatoosh intrusive suite plutons developed internal compositional variation. Geochemical and petrographic trends within each pluton are most consistent with differential loss of residual melt, possibly represented by late aplite dikes or erupted as rhyolite, from crystal-rich magma. Crystal-rich magma that formed each pluton evidently accumulated in reservoirs below the present level of exposure and then intruded to a shallow depth. Assembled by episodic intrusion, the Tatoosh intrusive suite may be representative of midsized composite plutonic complexes beneath arc volcanoes. ?? 2011 Geological Society of America.

  17. Development of an online men’s suits customizing system using heuristic procedure for wheelchair users

    NARCIS (Netherlands)

    Jeong, Minseok; Yang, Chuneun; You, Heecheon; Park, Kwangae; Lee, W.

    2016-01-01

    An online suit-customizing system for the special accessibility needs of wheelchair users should be developed because the demand for business suits by wheelchair users involved in economic activities has increased. This study
    develops a user interface an online customizing system for men's suits

  18. Development of a Fan for Future Space Suit Applications

    Science.gov (United States)

    Paul. Heather L.; Converse, David; Dionne, Steven; Moser, Jeff

    2010-01-01

    NASA's next generation space suit system will place new demands on the fan used to circulate breathing gas through the ventilation loop of the portable life support system. Long duration missions with frequent extravehicular activities (EVAs), the requirement for significant increases in reliability and durability, and a mission profile that imposes strict limits on weight, volume and power create the basis for a set of requirements that demand more performance than is available from existing fan designs. This paper describes the development of a new fan to meet these needs. A centrifugal fan was designed with a normal operating speed of approximately 39,400 rpm to meet the ventilation flow requirements while also meeting the aggressive minimal packaging, weight and power requirements. The prototype fan also operates at 56,000 rpm to satisfy a second operating condition associated with a single fan providing ventilation flow to two spacesuits connected in series. This fan incorporates a novel nonmetallic "can" to keep the oxygen flow separate from the motor electronics, thus eliminating ignition potential. The nonmetallic can enables a small package size and low power consumption. To keep cost and schedule within project bounds a commercial motor controller was used. The fan design has been detailed and implemented using materials and approaches selected to address anticipated mission needs. Test data is presented to show how this fan performs relative to anticipated ventilation requirements for the EVA portable life support system. Additionally, data is presented to show tolerance to anticipated environmental factors such as acoustics, shock, and vibration. Recommendations for forward work to progress the technology readiness level and prepare the fan for the next EVA space suit system are also discussed.

  19. Cognitive load privileges memory-based over data-driven processing, not group-level over person-level processing.

    Science.gov (United States)

    Skorich, Daniel P; Mavor, Kenneth I

    2013-09-01

    In the current paper, we argue that categorization and individuation, as traditionally discussed and as experimentally operationalized, are defined in terms of two confounded underlying dimensions: a person/group dimension and a memory-based/data-driven dimension. In a series of three experiments, we unconfound these dimensions and impose a cognitive load. Across the three experiments, two with laboratory-created targets and one with participants' friends as the target, we demonstrate that cognitive load privileges memory-based over data-driven processing, not group- over person-level processing. We discuss the results in terms of their implications for conceptualizations of the categorization/individuation distinction, for the equivalence of person and group processes, for the ultimate 'purpose' and meaningfulness of group-based perception and, fundamentally, for the process of categorization, broadly defined. © 2012 The British Psychological Society.

  20. Ventilation Transport Trade Study for Future Space Suit Life Support Systems

    Science.gov (United States)

    Kempf, Robert; Vogel, Matthew; Paul, Heather L.

    2008-01-01

    A new and advanced portable life support system (PLSS) for space suit surface exploration will require a durable, compact, and energy efficient system to transport the ventilation stream through the space suit. Current space suits used by NASA circulate the ventilation stream via a ball-bearing supported centrifugal fan. As NASA enters the design phase for the next generation PLSS, it is necessary to evaluate available technologies to determine what improvements can be made in mass, volume, power, and reliability for a ventilation transport system. Several air movement devices already designed for commercial, military, and space applications are optimized in these areas and could be adapted for EVA use. This paper summarizes the efforts to identify and compare the latest fan and bearing technologies to determine candidates for the next generation PLSS.

  1. Associations of group level popularity with observed behavior and influence in a dyadic context.

    Science.gov (United States)

    Lansu, Tessa A M; Cillessen, Antonius H N

    2015-12-01

    This study examined the association between popularity in the peer group and adolescents' behavior in a dyadic context. After collecting peer nominations for popularity, 218 early adolescents (M(age) = 11.0 years) in 109 randomly composed same-sex dyads participated in a discussion task where they planned a party for their classroom. From digital recordings of the sessions, each participant's influence, involvement, skillful leadership, coercive resource control, submissiveness, positivity, and negativity were observed. Analyses with the actor-partner interdependence model (APIM) demonstrated that for girls high group level popularity was associated with a socially sensitive interaction style and influence in the dyadic context. For both boys and girls, the interaction partner's group level popularity negatively predicted their use of coercive resource control strategies and negative behavior in the dyad. For girls, in addition, the interaction partner's group level popularity also positively predicted their submissiveness and negatively predicted their task influence. These results indicate that, in particular for girls, adolescents' group level popularity plays an important role in the behavior of both peers in a cooperative dyadic context. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Adherence to Technology-Mediated Insomnia Treatment: A Meta-Analysis, Interviews, and Focus Groups

    OpenAIRE

    Horsch, Corine; Lancee, Jaap; Beun, Robbert Jan; Neerincx, Mark A; Brinkman, Willem-Paul

    2015-01-01

    Background: Several technologies have been proposed to support the reduction of insomnia complaints. A user-centered assessment of these technologies could provide insight into underlying factors related to treatment adherence. Objective: Gaining insight into adherence to technology-mediated insomnia treatment as a solid base for improving those adherence rates by applying adherence-enhancing strategies. Methods: Adherence to technology-mediated sleep products was studied in three ways. First...

  3. High Performance Electrical Modeling and Simulation Verification Test Suite - Tier I; TOPICAL

    International Nuclear Information System (INIS)

    SCHELLS, REGINA L.; BOGDAN, CAROLYN W.; WIX, STEVEN D.

    2001-01-01

    This document describes the High Performance Electrical Modeling and Simulation (HPEMS) Global Verification Test Suite (VERTS). The VERTS is a regression test suite used for verification of the electrical circuit simulation codes currently being developed by the HPEMS code development team. This document contains descriptions of the Tier I test cases

  4. Telemetry Standards, IRIG Standard 106-17, Chapter 22, Network Based Protocol Suite

    Science.gov (United States)

    2017-07-01

    requirements. 22.2 Network Access Layer 22.2.1 Physical Layer Connectors and cable media should meet the electrical or optical properties required by the...Telemetry Standards, IRIG Standard 106-17 Chapter 22, July 2017 i CHAPTER 22 Network -Based Protocol Suite Acronyms...iii Chapter 22. Network -Based Protocol Suite

  5. Mercury levels in defined Italian population groups

    International Nuclear Information System (INIS)

    Ingrao, G.; Belloni, P.

    1991-01-01

    Our group conducts its research activity in the Department AMB-BIO (Biological and Sanitary Effect of Toxic Agents) of ENEA (National Committee for Research and Development of Nuclear and Alternative Energy) at the research centre of Casaccia. The food chain is the main pathway leading to humans for most of the trace elements. The research, therefore, has been directed mainly towards the study of the variability of the trace element content in the Italian diet. This programme aims at assessing the adequacy of the essential trace elements ingestion, and to verify that the ingestion of toxic trace elements is below the recommended values. Part of this research was conducted in the frame of the IAEA CRP on ''Human daily Intakes of Nutritionally Important Trace Elements as Measured by Nuclear and Other Techniques''. Studies carried out by the National Institute of Nutrition and FAO have shown that there are some population groups having a fish consumption significantly higher than the average value for the Italian population. These groups are usually found in coastal towns were fishing is one of the main occupation and generally includes fishermen, fish dealers, restaurant workers and their families. A pilot study was conducted in one of these towns, Bagnara Calabra in the South of Italy, where the average fish consumption is 27.1 kg per year, which is more than twice the national average. The results have shown that the mercury concentration in the diet is significantly higher than in other Italian locations, the mercury levels in blood and hair sample in these subjects are also significantly higher than the values reported for subjects of the general Italian population. 6 refs

  6. Reservoir water level forecasting using group method of data handling

    Science.gov (United States)

    Zaji, Amir Hossein; Bonakdari, Hossein; Gharabaghi, Bahram

    2018-06-01

    Accurately forecasted reservoir water level is among the most vital data for efficient reservoir structure design and management. In this study, the group method of data handling is combined with the minimum description length method to develop a very practical and functional model for predicting reservoir water levels. The models' performance is evaluated using two groups of input combinations based on recent days and recent weeks. Four different input combinations are considered in total. The data collected from Chahnimeh#1 Reservoir in eastern Iran are used for model training and validation. To assess the models' applicability in practical situations, the models are made to predict a non-observed dataset for the nearby Chahnimeh#4 Reservoir. According to the results, input combinations (L, L -1) and (L, L -1, L -12) for recent days with root-mean-squared error (RMSE) of 0.3478 and 0.3767, respectively, outperform input combinations (L, L -7) and (L, L -7, L -14) for recent weeks with RMSE of 0.3866 and 0.4378, respectively, with the dataset from https://www.typingclub.com/st. Accordingly, (L, L -1) is selected as the best input combination for making 7-day ahead predictions of reservoir water levels.

  7. An integrative variant analysis suite for whole exome next-generation sequencing data

    Directory of Open Access Journals (Sweden)

    Challis Danny

    2012-01-01

    Full Text Available Abstract Background Whole exome capture sequencing allows researchers to cost-effectively sequence the coding regions of the genome. Although the exome capture sequencing methods have become routine and well established, there is currently a lack of tools specialized for variant calling in this type of data. Results Using statistical models trained on validated whole-exome capture sequencing data, the Atlas2 Suite is an integrative variant analysis pipeline optimized for variant discovery on all three of the widely used next generation sequencing platforms (SOLiD, Illumina, and Roche 454. The suite employs logistic regression models in conjunction with user-adjustable cutoffs to accurately separate true SNPs and INDELs from sequencing and mapping errors with high sensitivity (96.7%. Conclusion We have implemented the Atlas2 Suite and applied it to 92 whole exome samples from the 1000 Genomes Project. The Atlas2 Suite is available for download at http://sourceforge.net/projects/atlas2/. In addition to a command line version, the suite has been integrated into the Genboree Workbench, allowing biomedical scientists with minimal informatics expertise to remotely call, view, and further analyze variants through a simple web interface. The existing genomic databases displayed via the Genboree browser also streamline the process from variant discovery to functional genomics analysis, resulting in an off-the-shelf toolkit for the broader community.

  8. Standardized Effect Size Measures for Mediation Analysis in Cluster-Randomized Trials

    Science.gov (United States)

    Stapleton, Laura M.; Pituch, Keenan A.; Dion, Eric

    2015-01-01

    This article presents 3 standardized effect size measures to use when sharing results of an analysis of mediation of treatment effects for cluster-randomized trials. The authors discuss 3 examples of mediation analysis (upper-level mediation, cross-level mediation, and cross-level mediation with a contextual effect) with demonstration of the…

  9. Authentic leadership and psychological well-being at work of nurses: The mediating role of work climate at the individual level of analysis

    Directory of Open Access Journals (Sweden)

    Katia Nelson

    2014-09-01

    Full Text Available Authentic leadership has been purported to influence psychological well-being through its impact on work climate. Using a sample of 406 nurses, a time-lagged study design was employed to determine the mediational role of work climate in explaining the impact of authentic leadership. Two self-reported questionnaires were completed to ascertain: (1 authentic leadership; and (2 work climate at baseline. In addition, nurses completed a measure to determine their level of psychological well-being at work at the 6 month time period. A mediation analysis with the use of a bootstrapping technique reveals that work climate mediates the relationship between authentic leadership and psychological well-being at work. These findings indicate that authentic leadership impacts the work climate in a positive manner; thereby, increasing levels of psychological well-being at work. We discuss theoretical and practical implications of the findings for future research as well as outline some limitations.

  10. Study on human-factors-engineering properties of reactor maintenance workers with protection suits, (2). Basic research on various biological characteristics in reactor maintenance simulation tests

    Energy Technology Data Exchange (ETDEWEB)

    Yoshino, K; Ishii, K; Nakasa, H [Central Research Inst. of Electric Power Industry, Tokyo (Japan); Shigeta, S

    1980-11-01

    To ensure the safety of reactor maintenance workers and to reduce the radiation exposure through the enhancement of labor efficiency, it is needed to evaluate quantitatively work-stress levels of workers with radiation-protection suits. This paper presents the results of reactor-maintenance simulation tests in which the relationship between the work stress and biological characteristics is investigated for 5 pinds of model works done by testees without protection suits in an artificial climate chamber. Major results obtained are: (1) the selected model works are mostly evaluated to be relatively heavy through the measurement of RMR (Relative Metabolic Rate). (2) biological characteristics such as heart rate and respiratory volume under the model works have close relationship to RMR which is the cumulative quantity in relatively long time, and then they may become the real-time indicator for the work stress level. (3) such biological characteristics are greatly affected by the high-temperature work-environment which is often seen in workers with protection suits.

  11. Effect of flurbiprofen axetil pretreatment on the pain degree as well as stress hormone and mediator secretion after abdominal surgery

    Directory of Open Access Journals (Sweden)

    Ying Chen

    2017-07-01

    Full Text Available Objective: To study the effect of flurbiprofen axetil pretreatment on the pain degree as well as stress hormone and mediator secretion after abdominal surgery. Methods: Patients undergoing abdominal surgery in our hospital between May 2015 and March 2017 were selected and randomly divided into two groups, intervention group received flurbiprofen axetil pretreatment combined with routine intravenous anesthesia, and the control group only accepted conventional intravenous anesthesia. The levels of pain neurotransmitters and cytokines, stress hormones and mediators in serum were detected before operation as well as 12 h and 24 h after operation. Results: 12 h and 24 h after operation, serum NPY, SP, Glu, TNF-α, IL-2, IL-6, IL- 10, ACTH, Cor, Ins, NE and E levels of both groups of patients were significantly higher than those before operation while SOD, GHS-Px and HO-1 levels were significantly lower than those before operation, and serum NPY, SP, Glu, TNF-α, IL-2, IL-6, IL-10, ACTH, Cor, Ins, NE and E levels of intervention group 12 h and 24 h after operation were significantly lower than those of control group while SOD, GHS-Px and HO-1 levels were significantly higher than those of control group. Conclusion: Flurbiprofen axetil pretreatment can reduce the pain degree and stress response after abdominal surgery.

  12. Wireless Wearable Multisensory Suite and Real-Time Prediction of Obstructive Sleep Apnea Episodes.

    Science.gov (United States)

    Le, Trung Q; Cheng, Changqing; Sangasoongsong, Akkarapol; Wongdhamma, Woranat; Bukkapatnam, Satish T S

    2013-01-01

    Obstructive sleep apnea (OSA) is a common sleep disorder found in 24% of adult men and 9% of adult women. Although continuous positive airway pressure (CPAP) has emerged as a standard therapy for OSA, a majority of patients are not tolerant to this treatment, largely because of the uncomfortable nasal air delivery during their sleep. Recent advances in wireless communication and advanced ("bigdata") preditive analytics technologies offer radically new point-of-care treatment approaches for OSA episodes with unprecedented comfort and afforadability. We introduce a Dirichlet process-based mixture Gaussian process (DPMG) model to predict the onset of sleep apnea episodes based on analyzing complex cardiorespiratory signals gathered from a custom-designed wireless wearable multisensory suite. Extensive testing with signals from the multisensory suite as well as PhysioNet's OSA database suggests that the accuracy of offline OSA classification is 88%, and accuracy for predicting an OSA episode 1-min ahead is 83% and 3-min ahead is 77%. Such accurate prediction of an impending OSA episode can be used to adaptively adjust CPAP airflow (toward improving the patient's adherence) or the torso posture (e.g., minor chin adjustments to maintain steady levels of the airflow).

  13. Stimulating Autonomous Learning Environments: Considering Group Efficacy as Mediating the Relationship between Perceived Autonomy Support and Self- Determinism in the Learning Environment

    Science.gov (United States)

    Hogan, Shannon L.

    2012-01-01

    This study researched 120 college students and professors to test the mediation of group efficacy between perceived autonomy support and self-determinism. The study provided surveys to students in eight different classes. Studying multiple classes offered an opportunity to understand the model more effectively and in a broader scope. The classes…

  14. Inflammatory Mediators in Induced Sputum and Airway Hyperresponsiveness in Cough Variant Asthma during Long-Term Inhaled Corticosteroid Treatment

    Directory of Open Access Journals (Sweden)

    Meixuan Liu

    2012-01-01

    Full Text Available Objective. This study aimed to investigate improvements in inflammatory mediator levels in induced sputum and airway hyperresponsiveness (AHR in cough variant asthma (CVA during long-term inhaled corticosteroid (ICS treatment. Patients and Methods. Patients with CVA (=35 and classic asthma (=26 and healthy subjects (=24 were recruited into this study. All patients were treated with budesonide (400 μg/day. Measurement of inflammatory mediators in induced sputum and PD20-FEV1 (the accumulated provocative dose resulting in a 20% decrease in FEV1 in histamine-challenged subjects was performed every three months after the start of medication. Interleukin- (IL- 5 and IL-10 were assayed by ELISA, and the percentage of eosinophils was detected with Giemsa stain. Trends during the follow-up period were analyzed using a general linear model. Results. Inflammatory mediator levels in induced sputum and PD20-FEV1 in patients with CVA and classic asthma differed from those in the control group, although no differences were found in the two asthmatic groups. PD20-FEV1 significantly increased in CVA patients after ICS treatment for 3 months, while classic asthma patients exhibited a delayed change in AHR. After ICS treatment, levels of IL-5 and IL-10 as well as the percentage of eosinophils in the CVA group were altered at 3 months and 6 months, respectively. Accordingly, the level of inflammatory mediators in classic asthma changed more slowly. Conclusion. CVA has a greater improvement in airway inflammation and airway hyperresponsiveness (AHR than classic asthma with respect to inhaled corticosteroid (ICS. Short-term ICS considerably reduces AHR although longer treatment is required for complete control of airway inflammation.

  15. Adobe Creative Suite 6 Design and Web Premium all-in-one for dummies

    CERN Document Server

    Smith, Jennifer; Gerantabee, Fred

    2012-01-01

    The must-have book on the leading suite of software for graphic and web designers Fully revised and updated this hands-on resource offers a one-stop learning opportunity through eight mini-book dedicated to each product inside Adobe's Design & Web Premium Suite. The mini-books include Adobe Creative Suite Basics, InDesign, Illustrator, Photoshop, Acrobat, Dreamweaver, Flash, Fireworks. The book may contain new image enhancements to After Effects, 64-bit versions of Illustrator and Flash Professional, and a new tool, dubbed Helium, that will enable designers to create content using HTML5 and

  16. Effects of aerobic exercise training on ACE and ADRB2 gene expression, plasma angiotensin II level, and flow-mediated dilation: a study on obese postmenopausal women with prehypertension.

    Science.gov (United States)

    Azadpour, Noushin; Tartibian, Bakhtyar; Koşar, Şükran Nazan

    2017-03-01

    The purpose of this study is to determine the effect of 10 weeks of moderate-intensity aerobic exercise training (MIET) on blood pressure (BP), angiotensin-converting enzyme (ACE) and β2-adrenergic receptor (ADRB2) gene expression in leukocytes, plasma angiotensin II (Ang II), and flow-mediated dilation (FMD) in obese postmenopausal women (PMW) with prehypertension. Twenty-four obese prehypertensive PMW (aged 50-70 y; body mass index ≥30 kg/m) randomly assigned to control (n = 12) and exercise (n = 12) groups. Exercise group performed MIET (25-40 min/d, 3 d/wk at 50%-70% of heart rate reserve) for 10 weeks. Control group maintained their normal daily physical activity level. Body composition, VO2max, BP, ACE and ADRB2 gene expression, plasma Ang II, and FMD were measured before and after the training program. After MIET, systolic and diastolic BPs decreased by 4.6% and 2.4%, respectively (P ACE gene expressions (P ACE (r values range 0.68-0.86) (P ACE and ADRB2 gene expression, decreases Ang II plasma levels, and improves endothelial function in obese PMW, and these alterations are associated with reduction in BP.

  17. Experimental Evaluation of Energy Efficiency for a Soft Wearable Robotic Suit.

    Science.gov (United States)

    Jin, Shanhai; Iwamoto, Noriyasu; Hashimoto, Kazunobu; Yamamoto, Motoji

    2016-10-12

    This paper presents a new soft wearable robotic suit for energy-efficient walking in daily activities for elderly persons. The presented robotic suit provides a small yet effective assistive force for hip flexion through winding belts that include elastic elements. In addition, it does not restrict the range of movement in the lower limbs. Moreover, its structure is simple and lightweight, and thus wearers can easily take the device on and off by themselves. Experimental results on nine elderly subjects (age = 74.23.7 years) show that the robotic suit worn and powered on (PON) significantly reduced energy expenditure by an average of 5.9 % compared with the condition of worn but powered off (POFF). Furthermore, compared with the POFF condition, there was a significant improvement in gait characteristics in the PON condition for all subjects.

  18. Asteroid Redirect Crewed Mission Space Suit and EVA System Architecture Trade Study

    Science.gov (United States)

    Bowie, Jonathan; Buffington, Jesse; Hood, Drew; Kelly, Cody; Naids, Adam; Watson, Richard; Blanco, Raul; Sipila, Stephanie

    2014-01-01

    The Asteroid Redirect Crewed Mission (ARCM) requires a Launch/Entry/Abort (LEA) suit capability and short duration Extra Vehicular Activity (EVA) capability from the Orion spacecraft. For this mission, the pressure garment selected for both functions is the Modified Advanced Crew Escape Suit (MACES) with EVA enhancements and the life support option that was selected is the Exploration Portable Life Support System (PLSS) currently under development for Advanced Exploration Systems (AES). The proposed architecture meets the ARCM constraints, but much more work is required to determine the details of the suit upgrades, the integration with the PLSS, and the tools and equipment necessary to accomplish the mission. This work has continued over the last year to better define the operations and hardware maturation of these systems. EVA simulations were completed in the Neutral Buoyancy Lab (NBL) and interfacing options were prototyped and analyzed with testing planned for late 2014. This paper discusses the work done over the last year on the MACES enhancements, the use of tools while using the suit, and the integration of the PLSS with the MACES.

  19. Mindfulness facets as differential mediators of short and long-term effects of Mindfulness-Based Cognitive Therapy in diabetes outpatients

    DEFF Research Database (Denmark)

    Haenen, Sharon; Nyklíček, Ivan; VAN Son, Jenny

    2016-01-01

    BACKGROUND: There is increasing evidence that mindfulness-based interventions reduce psychological distress in various medical populations. However, it has hardly been studied if these effects are mediated by an increase in mindfulness. The aim of this study was to examine mediating effects...... of various mindfulness facets on effects of a Mindfulness Based Cognitive Therapy (MBCT) on perceived stress and mood. METHODS: Outpatients with diabetes types 1 and 2 and low levels of emotional wellbeing were randomized into a group receiving MBCT (n=70) or a waiting-list control group (n=69). Primary...... outcomes were mood and perceived stress. Before, after and at follow-up (6months post intervention) relevant questionnaires were completed. RESULTS: Mediation analysis using bootstrap resampling indicated that increases in total mindfulness and the facets observing and nonreactivity mediated the effects...

  20. Leveraging Active Knit Technologies for Aerospace Pressure Suit Applications

    Data.gov (United States)

    National Aeronautics and Space Administration — Anti-Gravity Suits (AGS) are garments used in astronautics to prevent crew from experiencing orthostatic intolerance (OI) and consequential blackouts while...

  1. Safety Tips: Avoiding Negligence Suits in Chemistry Teaching.

    Science.gov (United States)

    Gerlovich, Jack A.

    1983-01-01

    Discusses various aspects related to negligence on the part of chemistry teachers. Areas addressed include negligence in tort law, avoiding negligence suits, proper instructions, proper supervision, equipment maintenance, and other considerations such as sovereign immunity, and contributory versus comparative negligence. (JN)

  2. Recommendations of the LHC Dark Matter Working Group: Comparing LHC searches for heavy mediators of dark matter production in visible and invisible decay channels arXiv

    CERN Document Server

    Albert, Andreas; Boveia, Antonio; Buchmueller, Oliver; Busoni, Giorgio; De Roeck,Albert; Doglioni, Caterina; DuPree, Tristan; Fairbairn, Malcolm; Genest, Marie-Hélène; Gori, Stefania; Gustavino, Giuliano; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Hayden, Dan; Ippolito, Valerio; John, Isabelle; Kahlhoefer, Felix; Kulkarni, Suchita; Landsberg, Greg; Lowette, Steven; Mawatari, Kentarou; Riotto, Antonio; Shepherd, William; Tait, Tim M.P.; Tolley, Emma; Tunney, Patrick; Zaldivar, Bryan; Zinser, Markus

    Weakly-coupled TeV-scale particles may mediate the interactions between normal matter and dark matter. If so, the LHC would produce dark matter through these mediators, leading to the familiar "mono-X" search signatures, but the mediators would also produce signals without missing momentum via the same vertices involved in their production. This document from the LHC Dark Matter Working Group suggests how to compare searches for these two types of signals in case of vector and axial-vector mediators, based on a workshop that took place on September 19/20, 2016 and subsequent discussions. These suggestions include how to extend the spin-1 mediated simplified models already in widespread use to include lepton couplings. This document also provides analytic calculations of the relic density in the simplified models and reports an issue that arose when ATLAS and CMS first began to use preliminary numerical calculations of the dark matter relic density in these models.

  3. The Process and Experience of Online Group Counseling for Masters-Level Counseling Students

    Science.gov (United States)

    Lopresti, Jason Michael

    2010-01-01

    The present study explored the process and experience of online group counseling using a text-based synchronous program, particularly addressing how the process compares to face-to-face group counseling. Six students in a masters-level group counseling class voluntarily chose to participate for eight sixty minute online sessions on a weekly basis,…

  4. Small Group Learning: Do Group Members' Implicit Theories of Ability Make a Difference?

    Science.gov (United States)

    Beckmann, Nadin; Wood, Robert E.; Minbashian, Amirali; Tabernero, Carmen

    2012-01-01

    We examined the impact of members' implicit theories of ability on group learning and the mediating role of several group process variables, such as goal-setting, effort attributions, and efficacy beliefs. Comparisons were between 15 groups with a strong incremental view on ability (high incremental theory groups), and 15 groups with a weak…

  5. Advanced Gas Sensing Technology for Space Suits, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced space suits require lightweight, low-power, durable sensors for monitoring critical life support materials. No current compact sensors have the tolerance...

  6. Affective mediators of a physical activity intervention for depression in multiple sclerosis.

    Science.gov (United States)

    Kratz, Anna L; Ehde, Dawn M; Bombardier, Charles H

    2014-02-01

    Previous analyses showed that a telephone-based intervention to increase physical activity in individuals with multiple sclerosis (MS) and depression resulted in significantly improved depressive symptoms compared to a wait-list control group. The aim of this study was to test positive affect and negative affect as mediators of the effect of the physical activity counseling on depressive symptoms. Ninety-two adults with MS, who met diagnostic criteria for either major depression or dysthymia and who reported low levels of physical activity, were randomized 1:1 to a 12-week telephone-based motivational interviewing (MI) intervention to improve physical activity (n = 44) or to a 12-week wait-list control group (n = 48). Self-reported positive and negative affect, physical activity, and depressive symptoms were gathered at baseline and postintervention. Path-analysis was used to test whether positive affect and negative affect mediated the positive effects of the intervention on depressive symptoms. Both positive and negative affect were significant mediators of the effects of the intervention on depressive symptoms; however, only positive affect mediated the association between changes in physical activity and improved depressive symptoms. Findings support physical activity and positive affect as key mediators of the MI treatment effect on improved mood. Decreases in negative affect were also evident in the treatment group, but were not related to improved physical activity. Findings may suggest the use of exercise-based interventions in conjunction with treatments that specifically target negative affective mechanisms for depression. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  7. Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels

    Directory of Open Access Journals (Sweden)

    Dicker Bridget L

    2007-06-01

    Full Text Available Abstract Background Alzheimer's disease (AD is characterized by a decline in cognitive function and accumulation of amyloid-β peptide (Aβ in extracellular plaques. Mutations in amyloid precursor protein (APP and presenilins alter APP metabolism resulting in accumulation of Aβ42, a peptide essential for the formation of amyloid deposits and proposed to initiate the cascade leading to AD. However, the role of Aβ40, the more prevalent Aβ peptide secreted by cells and a major component of cerebral Aβ deposits, is less clear. In this study, virally-mediated gene transfer was used to selectively increase hippocampal levels of human Aβ42 and Aβ40 in adult Wistar rats, allowing examination of the contribution of each to the cognitive deficits and pathology seen in AD. Results Adeno-associated viral (AAV vectors encoding BRI-Aβ cDNAs were generated resulting in high-level hippocampal expression and secretion of the specific encoded Aβ peptide. As a comparison the effect of AAV-mediated overexpression of APPsw was also examined. Animals were tested for development of learning and memory deficits (open field, Morris water maze, passive avoidance, novel object recognition three months after infusion of AAV. A range of impairments was found, with the most pronounced deficits observed in animals co-injected with both AAV-BRI-Aβ40 and AAV-BRI-Aβ42. Brain tissue was analyzed by ELISA and immunohistochemistry to quantify levels of detergent soluble and insoluble Aβ peptides. BRI-Aβ42 and the combination of BRI-Aβ40+42 overexpression resulted in elevated levels of detergent-insoluble Aβ. No significant increase in detergent-insoluble Aβ was seen in the rats expressing APPsw or BRI-Aβ40. No pathological features were noted in any rats, except the AAV-BRI-Aβ42 rats which showed focal, amorphous, Thioflavin-negative Aβ42 deposits. Conclusion The results show that AAV-mediated gene transfer is a valuable tool to model aspects of AD pathology in

  8. Strengthening Purity: Moral Purity as a Mediator of Direct and Extended Cross-Group Friendships on Sexual Prejudice.

    Science.gov (United States)

    Vezzali, Loris; Brambilla, Marco; Giovannini, Dino; Paolo Colucci, Francesco

    2017-01-01

    The present research investigated whether enhanced perceptions of moral purity drive the effects of intergroup cross-group friendships on the intentions to interact with homosexuals. High-school students (N = 639) reported their direct and extended cross-group friendships with homosexuals as well as their beliefs regarding the moral character of the sexual minority. Participants further reported their desire to interact with homosexuals in the future. Results showed that both face-to-face encounters and extended contact with homosexuals increased their perceived moral purity, which in turn fostered more positive behavioral intentions. Results further revealed the specific role of moral purity in this sense, as differential perceptions along other moral domains (autonomy and community) had no mediation effects on behavioral tendencies toward homosexuals. The importance of these findings for improving intergroup relations is discussed, together with the importance of integrating research on intergroup contact and morality.

  9. Feedback-Mediated Upper Extremities Exercise: Increasing Patient Motivation in Poststroke Rehabilitation

    Directory of Open Access Journals (Sweden)

    Maša D. Popović

    2014-01-01

    Full Text Available Purpose. This proof-of-concept study investigated whether feedback-mediated exercise (FME of the affected arm of hemiplegic patients increases patient motivation and promotes greater improvement of motor function, compared to no-feedback exercise (NFE. Method. We developed a feedback-mediated treatment that uses gaming scenarios and allows online and offline monitoring of both temporal and spatial characteristics of planar movements. Twenty poststroke hemiplegic inpatients, randomly assigned to the FME and NFE group, received therapy five days a week for three weeks. The outcome measures were evaluated from the following: (1 the modified drawing test (mDT, (2 received therapy time—RTT, and (3 intrinsic motivation inventory—IMI. Results. The FME group patients showed significantly higher improvement in the speed metric (P<0.01, and smoothness metric (P<0.01, as well as higher RTT (P<0.01. Significantly higher patient motivation is observed in the FME group (interest/enjoyment subscale (P<0.01 and perceived competence subscale (P<0.01. Conclusion. Prolonged endurance in training and greater improvement in certain areas of motor function, as well as very high patient motivation and strong positive impressions about the treatment, suggest the positive effects of feedback-mediated treatment and its high level of acceptance by patients.

  10. Social groups preferences relation to motivations and ability levels of whitewater kayakers

    Science.gov (United States)

    Seth Turner; Rod Zwick

    2002-01-01

    Social groups play an important role in many adventure recreation activities. The purpose of this study was to examine the social group preference relation to motives and ability levels of whitewater kayakers. When participants go out on a kayaking trip they are seeking varying degrees of experiences, a major contributor to that experience comes from the members of...

  11. INCREASED VASOOCCLUSIVE CRISIS IN “O” BLOOD GROUP SICKLE CELL DISEASE PATIENTS: ASSOCIATION WITH UNDERLYING THROMBOSPONDIN LEVELS.

    Directory of Open Access Journals (Sweden)

    M. Al Huneini

    2017-04-01

    Full Text Available Abstract: Objectives: To explore the incidence of vaso-occlusive crisis (VOC in Blood Group “O” sickle cell disease (SCD patients, and correlate it with the blood group and thrombospondin (TSP levels. Methods: In 89 consecutive SCD patients, blood samples were obtained for vWF antigen, collagen binding activity, blood group typing, C-reactive protein, variant hemoglobin analysis (HPLC, Serum TSP 1 and TSP 2 levels, complete blood counts, liver function tests, LDH and renal function tests during VOC episodes and in steady state conditions. Results: In the steady state SCD patients (n=72, “O” blood group patients (n=37 showed significantly higher median serum TSP 1 and TSP 2 levels than the non “O” blood group patients [n=35] [p <0.05, Mann-Whitney test], with an inverse relation between VWF:Ag, Factor VIII:C and TSP levels. Furthermore, the serum TSP 1 and TSP 2 levels were significantly higher in patients presenting with acute VOC [n=17], and in those with repeated VOC’s (group 1, n=16 especially amongst those patients with blood group “O” [p, <0.05, Mann-Whitney test]. Conclusions: The study shows that there was an inverse relation between TSP and vWF levels, in blood group “O” SCD patients with an upregulation of the TSP levels. Expectedly, during active VOC crisis, the TSP 1 and TSP 2 levels were significantly elevated.    Key Words: VOC; SCD; TSP; vWD; Blood groups

  12. The IMBA suite: integrated modules for bioassay analysis

    Energy Technology Data Exchange (ETDEWEB)

    Birchall, A.; Jarvis, N.S.; Peace, M.S.; Riddell, A.E.; Battersby, W.P

    1998-07-01

    The increasing complexity of models representing the biokinetic behaviour of radionuclides in the body following intake poses problems for people who are required to implement these models. The problem is exacerbated by the current paucity of suitable software. In order to remedy this situation, a collaboration between British Nuclear Fuels, Westlakes Research Institute and the National Radiological Protection Board has started with the aim of producing a suite of modules for estimating intakes and doses from bioassay measurements using the new ICRP models. Each module will have a single purpose (e.g. to calculate respiratory tract deposition) and will interface with other software using data files. The elements to be implemented initially are plutonium, uranium, caesium, iodine and tritium. It is intended to make the software available to other parties under terms yet to be decided. This paper describes the proposed suite of integrated modules for bioassay analysis, IMBA. (author)

  13. 7 CFR 900.106 - Assignment of mediator.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Assignment of mediator. 900.106 Section 900.106 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Assignment of mediator. The Director of the Division shall assign a mediator, from the group designated by...

  14. A Potential Epigenetic Marker Mediating Serum Folate and Vitamin B12 Levels Contributes to the Risk of Ischemic Stroke

    Directory of Open Access Journals (Sweden)

    Loo Keat Wei

    2015-01-01

    Full Text Available Stroke is a multifactorial disease that may be associated with aberrant DNA methylation profiles. We investigated epigenetic dysregulation for the methylenetetrahydrofolate reductase (MTHFR gene among ischemic stroke patients. Cases and controls were recruited after obtaining signed written informed consents following a screening process against the inclusion/exclusion criteria. Serum vitamin profiles (folate, vitamin B12, and homocysteine were determined using immunoassays. Methylation profiles for CpGs A and B in the MTHFR gene were determined using a bisulfite-pyrosequencing method. Methylation of MTHFR significantly increased the susceptibility risk for ischemic stroke. In particular, CpG A outperformed CpG B in mediating serum folate and vitamin B12 levels to increase ischemic stroke susceptibility risks by 4.73-fold. However, both CpGs A and B were not associated with serum homocysteine levels or ischemic stroke severity. CpG A is a potential epigenetic marker in mediating serum folate and vitamin B12 to contribute to ischemic stroke.

  15. Self-concept mediates the relation between achievement and emotions in mathematics.

    Science.gov (United States)

    Van der Beek, Jojanneke P J; Van der Ven, Sanne H G; Kroesbergen, Evelyn H; Leseman, Paul P M

    2017-09-01

    Mathematics achievement is related to positive and negative emotions. Pekrun's control-value theory of achievement emotions suggests that students' self-concept (i.e., self-appraisal of ability) may be an important mediator of the relation between mathematics achievement and emotions. The aims were (1) to investigate the mediating role of mathematical self-concept in the relation between mathematics achievement and the achievement emotions of enjoyment and anxiety in a comprehensive model, and (2) to test possible differences in this mediating role between low-, average-, and high-achieving students. Participants were ninth-grade students (n = 1,014) from eight secondary schools in the Netherlands. Through an online survey including mathematical problems, students were asked to indicate their levels of mathematics enjoyment, anxiety, and self-concept. Structural equation modelling was used to test the mediating role of self-concept in the relation between mathematics achievement and emotions. Multigroup analyses were performed to compare these relations across the three achievement groups. Results confirmed full mediation of the relation between mathematics achievement and emotions by mathematical self-concept. Furthermore, we found higher self-concepts, more enjoyment and less math anxiety in high-achieving students compared to their average and low-achieving peers. No differences across these achievement groups were found in the relations in the mediational model. Mathematical self-concept plays a pivotal role in students' appraisal of mathematics. Mathematics achievement is only one factor explaining students' self-concept. Likely also classroom instruction and teachers' feedback strategies help to shape students' self-concept. © 2017 The British Psychological Society.

  16. COMPARISON OF LEVELS OF SELF-ESTEEM BY SEX AND LEVEL OF PHYSICAL ACTIVITY IN TWO GROUPS OF SENIOR ADULTS

    Directory of Open Access Journals (Sweden)

    Diego Rodríguez Méndez

    2016-08-01

    Full Text Available The purpose of this study is to observe whether there are differences in the self-esteem score, depending on the level of physical activity (active-sedentary in a sample of senior adults. Twenty-six senior adults participated in the study with an average of 73 ± 9 years of age. The sedentary group (n = 12 belonged to the Santo Domingo Nursing Home in Heredia, Costa Rica, while the active group belonged to the project entitled Modulation of the Aging Process of the Movement for Life Program. Results: No significant differences were found in scores by level of physical activity (t = 0.931, p = 0.363; however, there were significant differences in self-esteem scores by gender (t = -2.255, p = 0.034. It was concluded that the level of physical activity does not affect self-esteem and that men’s level of self-esteem is higher than women’s.

  17. Isotopic variation in the Tuolumne Intrusive Suite, central Sierra Nevada, California

    Science.gov (United States)

    Kistler, R.W.; Chappell, B.W.; Peck, D.L.; Bateman, P.C.

    1986-01-01

    Granitoid rocks of the compositionally zoned Late Cretaceous Toulumne Intrusive Suite in the central Sierra Nevada, California, have initial87Sr/86Sr values (Sri) and143Nd/144Nd values (Ndi) that vary from 0.7057 to 0.7067 and from 0.51239 to 0.51211 respectively. The observed variation of both Sri and Ndi and of chemical composition in rocks of the suite cannot be due to crystal fractionation of magma solely under closed system conditons. The largest variation in chemistry, Ndi, and Sri is present in the outer-most equigranular units of the Tuolumne Intrusive Suite. Sri varies positively with SiO2, Na2O, K2O, and Rb concentrations, and negatively with Ndi, Al2O3, Fe2O3, MgO, FeO, CaO, MnO, P2O5, TiO2, and Sr concentrations. This covariation of Sri, Ndi and chemistry can be modeled by a process of simple mixing of basaltic and granitic magmas having weight percent SiO2 of 48.0 and 73.3 respectively. Isotopic characteristic of the mafic magma are Sri=0.7047, Ndi=0.51269 and ??18O=6.0, and of the felsic magma are Sri=0.7068, Ndi=0.51212 and ??18O=8.9. The rocks sampled contain from 50 to 80% of the felsic component. An aplite in the outer equigranular unit of the Tuolumne Intrusive Suite apparently was derived by fractional crystallization of plagioclase and hornblende from magma with granudiorite composition that was a product of mixing of the magmas described above. Siliceous magmas derived from the lower crust, having a maximum of 15 percent mantle-derived mafic component, are represented by the inner prophyritic units of the Tuolumne Intrusive Suite. ?? 1986 Springer-Verlag.

  18. Segane saksa-eesti kirjakeel ja eesti lauluraamat / Gustav Suits

    Index Scriptorium Estoniae

    Suits, Gustav, 1883-1956

    1999-01-01

    Varem ilmunud: Suits, Gustav. Eesti kirjanduslugu I. Lund : Eesti Kirjanike Kooperatiiv, 1953. Heinrich Stahli käsiraamatu Hand-, Hausz- und Kirchenbuch (1654-1656) osana ilmunud lauluraamatust Neu Ehstnisches Gesangbuch (1656)

  19. Assuring Condition and Inventory Accountability of Chemical Protective Suits

    National Research Council Canada - National Science Library

    2000-01-01

    .... As part of the Defense Logistics Agency's efforts to consolidate depot operations and improve inventory accuracy, chemical protective suits were transferred to the Defense Depot, Albany, Georgia, during FY 1991.

  20. Space Suit Simulator (S3) for Partial Gravity EVA Experimentation and Training, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Pressurized space suits impose high joint torques on the wearer, reducing mobility for upper and lower body motions. Using actual space suits in training or...

  1. Modular Algorithm Testbed Suite (MATS): A Software Framework for Automatic Target Recognition

    Science.gov (United States)

    2017-01-01

    NAVAL SURFACE WARFARE CENTER PANAMA CITY DIVISION PANAMA CITY, FL 32407-7001 TECHNICAL REPORT NSWC PCD TR-2017-004 MODULAR ...31-01-2017 Technical Modular Algorithm Testbed Suite (MATS): A Software Framework for Automatic Target Recognition DR...flexible platform to facilitate the development and testing of ATR algorithms. To that end, NSWC PCD has created the Modular Algorithm Testbed Suite

  2. The Evolution of Neutral Hydrogen in Galaxy Groups

    Science.gov (United States)

    Sanderson, Kelly Nicole; Wilcots, Eric; Hess, Kelley M.

    2018-01-01

    The Illustris suite of simulations is held as the standard of large scale gravitational and hydro-dynamical simulations and allows us to make a better comparisons with physical processes at the gaseous level by providing a higher mass resolution than previously available through the Millenium-II simulation. We present a comparison of an analysis on the HI content and distribution of galaxies in groups as a function of their group dark matter halo to the results of a large scale cosmological simulation. From the simulation we select optical group members above a Mr=-18 r-band magnitude and HI group members with HI above 109.5M⊙. We find that 74% of the HI detected galaxies are in groups or clusters and 84% of the optically detected galaxies are in groups or clusters. In the Hess & Wilcots (2013) paper it was found that as group membership, or group dark matter halo mass, increased, the fraction of galaxies detected in HI decreased and the spatial distribution of galaxies in these groups increased. We show the spatial distributions of galaxies, HI and optically detected, in order to reproduce these results. We find that Illustris qualitatively reproduces these trends, however, the simulation seems to be overestimating the mass of HI gas in all of its galaxies as well as the number of galaxies above the 109.5M⊙ limit.

  3. The audio and visual communication systems for suited engineering activities on JET

    International Nuclear Information System (INIS)

    Pearce, R.J.H.; Bruce, J.; Callaghan, C.; Hart, M.; Martin, P.; Middleton, R.; Tait, J.

    2001-01-01

    The beryllium and/or tritium contamination of the JET tokamak and auxiliary systems necessitates that many activities are carried out in air line fed pressurised suits. To enable often complex engineering activities to be performed, a number of novel audio and visual and communications systems have been designed. The paper describes these systems which give freedom of visual and audio communication between suited personnel, supervisors, operators and engineers. The system enhances the safety of the working environment as well as helping to minimise the radiation dose to personnel. It is concluded, from a number of years experience of using the audio and visual communications systems for suited operations, that safety and the progress of complex engineering tasks have been significantly enhanced

  4. The audio and visual communication systems for suited engineering activities on JET

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, R.J.H. E-mail: robert.pearce@jet.uk; Bruce, J.; Callaghan, C.; Hart, M.; Martin, P.; Middleton, R.; Tait, J

    2001-11-01

    The beryllium and/or tritium contamination of the JET tokamak and auxiliary systems necessitates that many activities are carried out in air line fed pressurised suits. To enable often complex engineering activities to be performed, a number of novel audio and visual and communications systems have been designed. The paper describes these systems which give freedom of visual and audio communication between suited personnel, supervisors, operators and engineers. The system enhances the safety of the working environment as well as helping to minimise the radiation dose to personnel. It is concluded, from a number of years experience of using the audio and visual communications systems for suited operations, that safety and the progress of complex engineering tasks have been significantly enhanced.

  5. Touring the Tomato: A Suite of Chemistry Laboratory Experiments

    Science.gov (United States)

    Sarkar, Sayantani; Chatterjee, Subhasish; Medina, Nancy; Stark, Ruth E.

    2013-01-01

    An eight-session interdisciplinary laboratory curriculum has been designed using a suite of analytical chemistry techniques to study biomaterials derived from an inexpensive source such as the tomato fruit. A logical

  6. Estimation of Indirect Effects in the Presence of Unmeasured Confounding for the Mediator-Outcome Relationship in a Multilevel 2-1-1 Mediation Model

    Science.gov (United States)

    Talloen, Wouter; Moerkerke, Beatrijs; Loeys, Tom; De Naeghel, Jessie; Van Keer, Hilde; Vansteelandt, Stijn

    2016-01-01

    To assess the direct and indirect effect of an intervention, multilevel 2-1-1 studies with intervention randomized at the upper (class) level and mediator and outcome measured at the lower (student) level are frequently used in educational research. In such studies, the mediation process may flow through the student-level mediator (the within…

  7. High plasma levels of high mobility group box 1 is associated with the risk of sepsis in severe blunt chest trauma patients: a prospective cohort study.

    Science.gov (United States)

    Wang, Xiao-Wen; Karki, Avash; Zhao, Xing-Ji; Xiang, Xiao-Yong; Lu, Zhi-Qian

    2014-08-02

    High mobility group box 1 (HMGB1) is a late mediator of systemic inflammation. Extracellular HMGB1 play a central pathogenic role in critical illness. The purpose of the study was to investigate the association between plasma HMGB1 concentrations and the risk of poor outcomes in patients with severe blunt chest trauma. The plasma concentrations of HMGB1 in patients with severe blunt chest trauma (AIS ≥ 3) were measured by a quantitative enzyme-linked immunosorbent assay at four time points during seven days after admission, and the dynamic release patterns were monitored. The biomarker levels were compared between patients with sepsis and non-sepsis, and between patients with multiple organ dysfunction syndrome (MODS) and non-MODS. The related factors of prognosis were analyzed by using multivariate logistic regression analysis. The short-form 36 was used to evaluate the quality of life of patients at 12 months after injury. Plasma HMGB1 levels were significantly higher both in sepsis and MODS group on post-trauma day 3, 5, and 7 compared with the non-sepsis and non-MODS groups, respectively. Multivariate analysis showed that HMGB1 levels and ISS were independent risk factors for sepsis and MODS in patients with severe blunt chest trauma. Plasma HMGB1 levels were significantly elevated in patients with severe blunt chest trauma. HMGB1 levels were associated with the risk of poor outcome in patients with severe blunt chest trauma. Daily HMGB1 levels measurements is a potential useful tool in the early identification of post-trauma complications. Further studies are needed to determine whether HMGB1 intervention could prevent the development of sepsis and MODS in patients with severe blunt chest trauma.

  8. When Membership Gives Strength to Act: Inclusion of the Group Into the Self and Feeling of Personal Agency.

    Science.gov (United States)

    Besta, Tomasz; Mattingly, Brent; Błażek, Magdalena

    2016-01-01

    Identity fusion theory suggests that merging groups into one's personal identity should result in heightened levels of group agency. Research on the self-expansion model complementarily indicates that including others into the self is linked to a greater feeling of self-efficacy. Across three correlational studies, we examined whether personal and group identity fusion is associated with stronger feelings of personal agency, and we propose that relatively stable feelings of clarity of self-concept would mediate this association. Individuals strongly fused with a country (Studies 1-3) and family (Study 2) exhibited greater feelings of agency and goal-adherence, and self-concept clarity emerged as a significant mediator of this association when controlling for group identification measures.

  9. Mediating influences of social support on stress at Three Mile Island.

    Science.gov (United States)

    Fleming, R; Baum, A; Gisriel, M M; Gatchel, R J

    1982-09-01

    Symptom reporting, task performance, and urinary catecholamine excretion were studied in a group of people living near the Three Mile Island nuclear power plant and in control populations. More than a year after the accident, living near the damaged reactor was associated with elevations in all indices of stress compared with control levels. Social support mediated these stress indices such that higher levels were associated with fewer psychological and behavioral symptoms of stress. Biochemical measures showed a different pattern of results.

  10. Mediating influences of social support on stress at Three Mile Island

    International Nuclear Information System (INIS)

    Fleming, R.; Baum, A.; Gisriel, M.M.; Gatchel, R.J.

    1982-01-01

    Symptom reporting, task performance, and urinary catecholamine excretion were studied in a group of people living near the Three Mile Island nuclear power plant and in control populations. More than a year after the accident, living near the damaged reactor was associated with elevations in all indices of stress compared with control levels. Social support mediated these stress indices such that higher levels were associated with fewer psychological and behavioral symptoms of stress. Biochemical measures showed a different pattern of results

  11. The effect of a novel photodynamic activation method mediated by curcumin on oyster shelf life and quality.

    Science.gov (United States)

    Liu, Fang; Li, Zhaojie; Cao, Binbin; Wu, Juan; Wang, Yuming; Xue, Yong; Xu, Jie; Xue, Changhu; Tang, Qing Juan

    2016-09-01

    In this paper, the effect of photodynamic method mediated by curcumin (PDT) on the shelf life and quality of pacific oysters during storage at 5±1°C were analyzed. In our previous study we investigated the optimal treatment conditions of photodynamic method mediated by curcumin to sterilization were 10uM photosensitizer concentration and 5.4J/cm 2 light energy density. Under these conditions, the effect of a novel photodynamic activation method mediated by curcumin on oyster shelf life and quality was researched. The total bacterial counts, TVB-N content and sensory analysis were used to evaluate the effects on oyster shelf life. The oyster shelf life was prolonged from 8days to 12days after photodynamic treatment and the oysters in the treatment group displayed notable odor retention, produced fewer odor corrupting substances when the control group oysters reached the end of their shelf life (day 8). Texture, free amino acid contents and fatty acid levels were applied to estimate the quality of the treated oysters. The texture had no significant change after treated with PDT. At the end of oyster shelf life, compared PDT group (PDT) with control group (control), total free amino acid contents (control: 234.30mg/100g, PDT: 813.02mg/100g) was higher and free fatty acid levels (control: 0.071mEq/L, PDT: 0.0455mEq/L) displayed lower in PDT group. This indicated that the treated oysters oxidized minimally, decayed slowly, decomposed fewer nutrients and had lower metabolic levels of spoilage microorganisms. PDT has a positive effect on prolonging oyster shelf life and its quality. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Impact of robotics and a suspended lead suit on physician radiation exposure during percutaneous coronary intervention.

    Science.gov (United States)

    Madder, Ryan D; VanOosterhout, Stacie; Mulder, Abbey; Elmore, Matthew; Campbell, Jessica; Borgman, Andrew; Parker, Jessica; Wohns, David

    Reports of left-sided brain malignancies among interventional cardiologists have heightened concerns regarding physician radiation exposure. This study evaluated the impact of a suspended lead suit and robotic system on physician radiation exposure during percutaneous coronary intervention (PCI). Real-time radiation exposure data were prospectively collected from dosimeters worn by operating physicians at the head- and chest-level during consecutive PCI cases. Exposures were compared in three study groups: 1) manual PCI performed with traditional lead apparel; 2) manual PCI performed using suspended lead; and 3) robotic PCI performed in combination with suspended lead. Among 336 cases (86.6% manual, 13.4% robotic) performed over 30weeks, use of suspended lead during manual PCI was associated with significantly less radiation exposure to the chest and head of operating physicians than traditional lead apparel (chest: 0.0 [0.1] μSv vs 0.4 [4.0] μSv, probotic PCI performed in combination with suspended lead was 0.0 [0.0] μSv, which was significantly less chest exposure than manual PCI performed with traditional lead (probotic PCI the median head-level exposure was 0.1 [0.2] μSv, which was 99.3% less than manual PCI performed with traditional lead (probotics were observed to result in significantly less radiation exposure to the chest and head of operating physicians during PCI. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Monitoring Human Performance During Suited Operations: A Technology Feasibility Study Using EMU Gloves

    Science.gov (United States)

    Bekdash, Omar; Norcross, Jason; McFarland, Shane

    2015-01-01

    Mobility tracking of human subjects while conducting suited operations still remains focused on the external movement of the suit and little is known about the human movement within it. For this study, accelerometers and bend sensitive resistors were integrated into a custom carrier glove to quantify range of motion and dexterity from within the pressurized glove environment as a first stage feasibility study of sensor hardware, integration, and reporting capabilities. Sensors were also placed on the exterior of the pressurized glove to determine if it was possible to compare a glove joint angle to the anatomical joint angle of the subject during tasks. Quantifying human movement within the suit was feasible, with accelerometers clearly detecting movements in the wrist and reporting expected joint angles at maximum flexion or extension postures with repeatability of plus or minus 5 degrees between trials. Bend sensors placed on the proximal interphalangeal and distal interphalangeal joints performed less well. It was not possible to accurately determine the actual joint angle using these bend sensors, but these sensors could be used to determine when the joint was flexed to its maximum and provide a general range of mobility needed to complete a task. Further work includes additional testing with accelerometers and the possible inclusion of hardware such as magnetometers or gyroscopes to more precisely locate the joint in 3D space. We hope to eventually expand beyond the hand and glove and develop a more comprehensive suit sensor suite to characterize motion across more joints (knee, elbow, shoulder, etc.) and fully monitor the human body operating within the suit environment.

  14. Leptin levels distribution and ethnic background in two populations from Chile: Caucasian and Mapuche groups.

    Science.gov (United States)

    Pérez-Bravo, F; Albala, C; Santos, J L; Yañez, M; Carrasco, E

    1998-10-01

    Leptin, the product of the human ob gene is increased in obese individuals, suggesting resistance to its effect. We examined the relationship of serum leptin levels with respect to obesity, gender and insulin levels in two populations with different ethnic compositions in Chile. Leptin and insulin levels were determined by radioimmunoassay (RIA) and correlated with body mass index (BMI), gender and ethnic background. 79 Caucasian subjects from Santiago and 65 Mapuche natives from the Araucania region, Chile, were included in this study. Leptin concentrations in obese subjects were significantly increased in both ethnic groups in relation to lean status: Caucasian and Mapuche obese 19.3 +/- 11.6 and 10.1 +/- 5.8 (P Mapuche lean 10.4 +/- 5.8 and 4.7 +/- 2.9 (P Mapuche and Caucasian groups, similar leptin levels were observed among the males of the two populations in both metabolic states (lean and obese). In contrast, the leptin level distributions between women showed a marked difference, having a minor value in the Mapuche women with a comparable value with the male group in this ethnic population. The leptin concentrations are associated with obesity in both ethnic groups in Chile. However, the leptin levels between the Mapuche natives were significantly decreased compared to the Caucasian group. The gender distribution does not seem to be important in the Mapuche natives. The ethnic composition seems to be important in the leptin distribution in the analysed populations.

  15. Urinary levels of high mobility group box-1 are associated with disease activity in antineutrophil cytoplasmic autoantibody-associated vasculitis.

    Directory of Open Access Journals (Sweden)

    Tian-Tian Ma

    Full Text Available High mobility group box-1 (HMGB1, a kind of pro-inflammatory mediator, is associated with inflammatory conditions and tissue damage. Our previous study demonstrated that the circulating levels of HMGB1 correlated with disease activity of antineutrophil cytoplasmic antibody (ANCA-associated vasculitis (AAV. In the current study, we aimed to measure urinary levels of HMGB1 in AAV patients, correlated them to clinical activity index and analysed the immunohistochemical HMGB1 staining in kidney specimens.50 patients with AAV in active stage and 56 patients with AAV in remission were recruited. The urinary levels of HMGB1 were determined by enzyme-linked immunosorbent assay. Moreover, renal biopsy specimens from 27 patients with active AAV were randomly collected to evaluate the deposition of HMGB1.Urinary HMGB1 levels in AAV patients in active stage were significantly higher than those in AAV patients in remission and healthy controls (1.46 [0.56-3.43] versus 0.38 [0.10-1.35] mg/μmolCr, P=0.001; 1.46 [0.56-3.43] versus 0.48 [0.40-0.60] mg/μmolCr, P=0.000, respectively. Further analysis found that urinary levels of HMGB1 correlated with erythrocyte sedimentation rate (r=0.354, p=0.012, C-reactive protein (r=0.289, p=0.042, and Birmingham Vasculitis Activity Score (r=0.350, p=0.013. Renal tissue of active AAV patients showed HMGB1 was mainly expressed in the cytoplasm and the extracellular space. The percentage of HMGB1-negative nuclei in renal tissue of patients with active AAV was significantly higher than that in normal controls (60.6±20.2 % versus 2.7±0.6 %, p<0.01.Urinary levels of HMGB1 may be associated with the disease activity in AAV patients.

  16. [The effect of group-based psychodrama therapy on decreasing the level of aggression in adolescents].

    Science.gov (United States)

    Karataş, Zeynep; Gökçakan, Dan Zafer

    2009-01-01

    This study aimed to examine the effect of group-based psychodrama therapy on the level aggression in adolescents. The study included 23 students from Nezihe Yalvac Anatolian Vocational High School of Hotel Management and Tourism that had high aggression scores. Eleven of the participants (6 female, 5 male) constituted the experimental group and 12 (6 male, 6 female) were in the control group. The 34-item Aggression Scale was used to measure level of aggression. We utilized mixed pattern design including experiment-control, pre-test and post test and follow up. The experimental group participated in group-based psychodrama therapy once a week for 90 minutes, for 14 weeks in total. The Aggression Scale was administered to the experimental and control groups before and after treatment; it was additionally administered to the experimental group 16 weeks after treatment. Data were analyzed using ANCOVA and dependent samples t tests. Our analysis shows that group-based psychodrama had an effect on the experimental group in terms of total aggression, anger, hostility, and indirect aggression scores (F=65.109, F=20.175, F=18.593, F=40.987, respectively, Ppsychodrama therapy decreased the level of aggression in the experimental group. Current findings are discussed with reference to the literature. Recommendations for further research and for psychiatric counselors are provided.

  17. Prokofiev: Romeo and Juliet - Suite N1 / Ivan March

    Index Scriptorium Estoniae

    March, Ivan

    1990-01-01

    Uuest heliplaadist "Prokofiev: Romeo and Juliet - Suite N1, Op.64b, N2, Op.64c. Philharmonia Orchestra, Barry Wordsworth" Collins Classics cassette 1116-4. CD. Võrreldud Neeme Järvi plaadistustega 1116-2

  18. Measuring total health inequality: adding individual variation to group-level differences

    Directory of Open Access Journals (Sweden)

    Gakidou Emmanuela

    2002-08-01

    Full Text Available Abstract Background Studies have revealed large variations in average health status across social, economic, and other groups. No study exists on the distribution of the risk of ill-health across individuals, either within groups or across all people in a society, and as such a crucial piece of total health inequality has been overlooked. Some of the reason for this neglect has been that the risk of death, which forms the basis for most measures, is impossible to observe directly and difficult to estimate. Methods We develop a measure of total health inequality – encompassing all inequalities among people in a society, including variation between and within groups – by adapting a beta-binomial regression model. We apply it to children under age two in 50 low- and middle-income countries. Our method has been adopted by the World Health Organization and is being implemented in surveys around the world; preliminary estimates have appeared in the World Health Report (2000. Results Countries with similar average child mortality differ considerably in total health inequality. Liberia and Mozambique have the largest inequalities in child survival, while Colombia, the Philippines and Kazakhstan have the lowest levels among the countries measured. Conclusions Total health inequality estimates should be routinely reported alongside average levels of health in populations and groups, as they reveal important policy-related information not otherwise knowable. This approach enables meaningful comparisons of inequality across countries and future analyses of the determinants of inequality.

  19. Failure to exercise due diligence costs plaintiff her suit.

    Science.gov (United States)

    1997-11-28

    The Mississippi State Supreme Court affirmed a lower court ruling dismissing a last-minute suit filed by a plaintiff against United Blood Services of Mississippi and the American Association of Blood Banks. A woman known as D. Doe was a recipient of a tainted transfusion. She contracted HIV in 1983 and died of AIDS-related causes in 1991. Her daughter, the plaintiff, filed a contaminated blood transfusion lawsuit just five days before the statute of limitations ran out but failed to ascertain the correct identity of the blood bank. She named two blood banks in her suit because she was unable to determine the source of the blood. The Supreme Court ruled that waiting until five days before the statute elapsed indicated that the plaintiff did not exercise reasonable diligence within a specific time frame.

  20. Perceived Parenting Styles Fail to Mediate between Anxiety and Attachment Styles in Adult Siblings of Individuals with Developmental Disabilities

    Science.gov (United States)

    O'Neill, Linda P.; Murray, Lindsay E.

    2016-01-01

    Adult siblings of individuals with developmental disabilities often experience higher levels of anxiety than individuals in the general population. The present study tested whether perceived parenting could mediate the relationship between attachment styles and anxiety in the sibling group compared to a control group. Little association was found…

  1. Childhood adversity and social functioning in psychosis: Exploring clinical and cognitive mediators.

    Science.gov (United States)

    Palmier-Claus, Jasper; Berry, Katherine; Darrell-Berry, Hannah; Emsley, Richard; Parker, Sophie; Drake, Richard; Bucci, Sandra

    2016-04-30

    Childhood adversity may increase risk of impaired social functioning across the continuum of psychosis. However, the pathways by which adversity dictates functional outcome remain underexplored. This study investigated the association between childhood adversity and social functioning, and the clinical and cognitive mediators of this relationship. Fifty-four clinical (20 chronic, 20 first episode, 14 at ultra-high risk) and 120 non-clinical participants completed standardised questionnaires, semi-structured interviews and tests of theory of mind ability. The authors used multiple group structural equation modelling to fit mediation models allowing for differential relationships between the clinical and non-clinical samples. When examining each pathway separately, depression, paranoia and anxious attachment mediated the effect of childhood adversity on social functioning. In a combined model, depression was the only significant mediating variable with greater adversity predicting lower mood across groups. Childhood adversity did not significantly predict theory of mind ability in any of the models. This is the first study to indicate that childhood adversity acts on social functioning by increasing levels of depression, suggesting a common mechanism across the spectrum of psychosis. Clinical interventions should target low mood in order to improve social functioning at all stages of psychotic disorder. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  2. Group cohesion in sports teams of different professional level

    OpenAIRE

    Vazha M. Devishvili; Marina O. Mdivani; Daria S. Elgina

    2017-01-01

    Background. Team sports are not only the most exciting sporting events. but also complex activities that make serious demands on players. The effectiveness of the team depends not only on the high level of gaming interaction. but also on the relationship between the players. The work is based on the material of sports teams and is devoted to the study of the phenomenon of group cohesion. As a basic model. the authors choose a 4-factor model that describes cohesion in sports teams. The pape...

  3. Combination therapies in adjuvant with topical ALA-mediated photodynamic therapy for DMBA-induced hamster buccal pouch premalignant lesions

    Science.gov (United States)

    Yang, Deng-Fu; Hsu, Yih-Chih

    2012-03-01

    In Taiwan, oral cancer has becomes the fastest growth male cancer disease due to the betel nut chewing habit combing with smoking and alcohol-drinking lifestyle of people. In order to eliminate the systemic phototoxic effect of 5-aminolevulinic acid (ALA), this study was designed to use a topical ALA-mediated PDT for treatment of DMBA-induced hamster buccal pouch precancerous lesions. DMBA was applied to one of the buccal pouches of hamsters thrice a week for 10 to 12 weeks. Cancerous lesions were induced and proven by histological examination. These DMBA-induced cancerous lesions were used for testing the efficacy of topical ALA-mediated PDT. Before PDT, fluorescence spectroscopy was used to determine when ALA reached its peak level in the lesional epithelial cells after topical application of ALA gel. We found that ALA reached its peak level in precancerous lesions about 2.5 hrs after topical application of ALA gel. The cancerous lesions in hamsters were then treated with topical ALA -mediated PDT with light exposure dose of 150 J/cm2 using LED 635 nm fiber-guided light device. Visual examination demonstrated that adjuvant topical ALA -mediated PDT group has shown better therapeutic results in compared to those of non-adjuvant topical ALA-mediated PDT group for DMBA-induced hamster buccal pouch precancerous lesions.

  4. A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution

    International Nuclear Information System (INIS)

    Al-Ejeh, Fares; Darby, Jocelyn M.; Thierry, Benjamin; Brown, Michael P.

    2009-01-01

    Introduction: Antibodies covalently conjugated with chelators such as 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) are required for radioimmunoscintigraphy and radioimmunotherapy, which are of growing importance in cancer medicine. Method: Here, we report a suite of simple methods that provide a preclinical assessment package for evaluating the effects of DOTA conjugation on the in vitro and in vivo performance of monoclonal antibodies. We exemplify the use of these methods by investigating the effects of DOTA conjugation on the biochemical properties of the DAB4 clone of the La/SSB-specific murine monoclonal autoantibody, APOMAB (registered) , which is a novel malignant cell death ligand. Results: We have developed a 96-well microtiter-plate assay to measure directly the concentration of DOTA and other chelators in antibody-chelator conjugate solutions. Coupled with a commercial assay for measuring protein concentration, the dual microtiter-plate method can rapidly determine chelator/antibody ratios in the same plate. The biochemical properties of DAB4 immunoconjugates were altered as the DOTA/Ab ratio increased so that: (i) mass/charge ratio decreased; (ii) hydrodynamic radius increased; (iii) antibody immunoactivity decreased; (iv) rate of chelation of metal ions and specific radioactivity both increased and in vivo, (v) tumor uptake decreased as nonspecific uptake by liver and spleen increased. Conclusion: This simplified suite of methods readily identifies biochemical characteristics of the DOTA-immunoconjugates such as hydrodynamic diameter and decreased mass/charge ratio associated with compromised immunotargeting efficiency and, thus, may prove useful for optimizing conjugation procedures in order to maximize immunoconjugate-mediated radioimmunoscintigraphy and radioimmunotherapy.

  5. Perceptions as the crucial link? The mediating role of neighborhood perceptions in the relationship between the neighborhood context and neighborhood cohesion.

    Science.gov (United States)

    Laméris, Joran; Hipp, John R; Tolsma, Jochem

    2018-05-01

    This study examines the effects of neighborhood racial in-group size, economic deprivation and the prevalence of crime on neighborhood cohesion among U.S. whites. We explore to what extent residents' perceptions of their neighborhood mediate these macro-micro relationships. We use a recent individual-level data set, the American Social Fabric Study (2012/2013), enriched with contextual-level data from the U.S. Census Bureau (2010) and employ multi-level structural equation models. We show that the racial in-group size is positively related to neighborhood cohesion and that neighborhood cohesion is lower in communities with a high crime rate. Individuals' perceptions of the racial in-group size partly mediate the relationship between the objective racial in-group size and neighborhood cohesion. Residents' perceptions of unsafety from crime also appear to be a mediating factor, not only for the objective crime rate but also for the objective racial in-group size. This is in line with our idea that racial stereotypes link racial minorities to crime whereby neighborhoods with a large non-white population are perceived to be more unsafe. Residents of the same neighborhood differ in how they perceive the degree of economic decay of the neighborhood and this causes them to evaluate neighborhood cohesion differently, however perceptions of neighborhood economic decay do not explain the link between the objective neighborhood context and neighborhood cohesion. Copyright © 2018. Published by Elsevier Inc.

  6. Time Management in the Operating Room: An Analysis of the Dedicated Minimally Invasive Surgery Suite

    Science.gov (United States)

    Hsiao, Kenneth C.; Machaidze, Zurab

    2004-01-01

    Background: Dedicated minimally invasive surgery suites are available that contain specialized equipment to facilitate endoscopic surgery. Laparoscopy performed in a general operating room is hampered by the multitude of additional equipment that must be transported into the room. The objective of this study was to compare the preparation times between procedures performed in traditional operating rooms versus dedicated minimally invasive surgery suites to see whether operating room efficiency is improved in the specialized room. Methods: The records of 50 patients who underwent laparoscopic procedures between September 2000 and April 2002 were retrospectively reviewed. Twenty-three patients underwent surgery in a general operating room and 18 patients in an minimally invasive surgery suite. Nine patients were excluded because of cystoscopic procedures undergone prior to laparoscopy. Various time points were recorded from which various time intervals were derived, such as preanesthesia time, anesthesia induction time, and total preparation time. A 2-tailed, unpaired Student t test was used for statistical analysis. Results: The mean preanesthesia time was significantly faster in the minimally invasive surgery suite (12.2 minutes) compared with that in the traditional operating room (17.8 minutes) (P=0.013). Mean anesthesia induction time in the minimally invasive surgery suite (47.5 minutes) was similar to time in the traditional operating room (45.7 minutes) (P=0.734). The average total preparation time for the minimally invasive surgery suite (59.6 minutes) was not significantly faster than that in the general operating room (63.5 minutes) (P=0.481). Conclusion: The amount of time that elapses between the patient entering the room and anesthesia induction is statically shorter in a dedicated minimally invasive surgery suite. Laparoscopic surgery is performed more efficiently in a dedicated minimally invasive surgery suite versus a traditional operating room. PMID

  7. Data processing software suite SITENNO for coherent X-ray diffraction imaging using the X-ray free-electron laser SACLA

    International Nuclear Information System (INIS)

    Sekiguchi, Yuki; Oroguchi, Tomotaka; Takayama, Yuki; Nakasako, Masayoshi

    2014-01-01

    The software suite SITENNO is developed for processing diffraction data collected in coherent X-ray diffraction imaging experiments of non-crystalline particles using an X-ray free-electron laser. Coherent X-ray diffraction imaging is a promising technique for visualizing the structures of non-crystalline particles with dimensions of micrometers to sub-micrometers. Recently, X-ray free-electron laser sources have enabled efficient experiments in the ‘diffraction before destruction’ scheme. Diffraction experiments have been conducted at SPring-8 Angstrom Compact free-electron LAser (SACLA) using the custom-made diffraction apparatus KOTOBUKI-1 and two multiport CCD detectors. In the experiments, ten thousands of single-shot diffraction patterns can be collected within several hours. Then, diffraction patterns with significant levels of intensity suitable for structural analysis must be found, direct-beam positions in diffraction patterns determined, diffraction patterns from the two CCD detectors merged, and phase-retrieval calculations for structural analyses performed. A software suite named SITENNO has been developed to semi-automatically apply the four-step processing to a huge number of diffraction data. Here, details of the algorithm used in the suite are described and the performance for approximately 9000 diffraction patterns collected from cuboid-shaped copper oxide particles reported. Using the SITENNO suite, it is possible to conduct experiments with data processing immediately after the data collection, and to characterize the size distribution and internal structures of the non-crystalline particles

  8. Placebo-mediated, Naloxone-sensitive suggestibility of short-term memory performance.

    Science.gov (United States)

    Stern, Jair; Candia, Victor; Porchet, Roseline I; Krummenacher, Peter; Folkers, Gerd; Schedlowski, Manfred; Ettlin, Dominik A; Schönbächler, Georg

    2011-03-01

    Physiological studies of placebo-mediated suggestion have been recently performed beyond their traditional clinical context of pain and analgesia. Various neurotransmitter systems and immunological modulators have been used in successful placebo suggestions, including Dopamine, Cholecystokinin and, most extensively, opioids. We adhered to an established conceptual framework of placebo research and used the μ-opioid-antagonist Naloxone to test the applicability of this framework within a cognitive domain (e.g. memory) in healthy volunteers. Healthy men (n=62, age 29, SD=9) were required to perform a task-battery, including standardized and custom-designed memory tasks, to test short-term recall and delayed recognition. Tasks were performed twice, before and after intravenous injection of either NaCl (0.9%) or Naloxone (both 0.15 mg/kg), in a double-blind setting. While one group was given neutral information (S-), the other was told that it might receive a drug with suspected memory-boosting properties (S+). Objective and subjective indexes of memory performance and salivary cortisol (as a stress marker) were recorded during both runs and differences between groups were assessed. Short-term memory recall, but not delayed recognition, was objectively increased after placebo-mediated suggestion in the NaCl-group. Naloxone specifically blocked the suggestion effect without interfering with memory performance. These results were not affected when changes in salivary cortisol levels were considered. No reaction time changes, recorded to uncover unspecific attentional impairment, were seen. Placebo-mediated suggestion produced a training-independent, objective and Naloxone-sensitive increase in memory performance. These results indicate an opioid-mediated placebo effect within a circumscribed cognitive domain in healthy volunteers. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. The efficacy of teachers' responses to incidents of bullying and victimization: The mediational role of moral disengagement for bullying.

    Science.gov (United States)

    Campaert, Kristel; Nocentini, Annalaura; Menesini, Ersilia

    2017-09-01

    Teachers respond differently to bullying and victimization. Socio-cognitive and moral domain theory suggest that students process teachers' behavior cognitively and that teachers' responses to incidents of bullying and victimization could affect students' level of moral disengagement. We examined the mediating effect of students' moral disengagement between types of teachers' responses to situations of bullying and victimization and individual bullying using multilevel mediation modelling. Participants were 609 students (50% boys, age M = 11.47, SD = 1.14) of central Italy, nested in 34 classes. Students rated the frequency of self-reported bullying and of teachers' responses to incidents of bullying and victimization on a 5-point Likert scale. Teachers' responses to bullying included non-intervention, mediation, group discussion, and sanctions. Teachers' responses to victimization included non-intervention, mediation, group discussion, and victim support. Results indicated that in the teachers' responses to incidents of bullying model, a significant indirect effect of non-intervention (β = .03; 95%CI [.01, .05]) and of sanctions (β = -.02; 95%CI [-.04, -.01]) on bullying through moral disengagement was found at the individual level. Similarly, in the model on teachers' responses toward victims there was a significant indirect effect through moral disengagement of non-intervention (β = .03; 95%CI [.02, .04]) and victim support (β = -.01; 95%CI [-.02, -.001]). At the class level there were no significant indirect effects. In sum, results indicated that moral disengagement is an important mediator at the individual level and suggest including teachers in anti-bullying interventions with a specific focus on their role for moral development. © 2017 Wiley Periodicals, Inc.

  10. Brassinosteroids Antagonize Gibberellin- and Salicylate-Mediated Root Immunity in Rice1[C][W][OA

    Science.gov (United States)

    De Vleesschauwer, David; Van Buyten, Evelien; Satoh, Kouji; Balidion, Johny; Mauleon, Ramil; Choi, Il-Ryong; Vera-Cruz, Casiana; Kikuchi, Shoshi; Höfte, Monica

    2012-01-01

    Brassinosteroids (BRs) are a unique class of plant steroid hormones that orchestrate myriad growth and developmental processes. Although BRs have long been known to protect plants from a suite of biotic and abiotic stresses, our understanding of the underlying molecular mechanisms is still rudimentary. Aiming to further decipher the molecular logic of BR-modulated immunity, we have examined the dynamics and impact of BRs during infection of rice (Oryza sativa) with the root oomycete Pythium graminicola. Challenging the prevailing view that BRs positively regulate plant innate immunity, we show that P. graminicola exploits BRs as virulence factors and hijacks the rice BR machinery to inflict disease. Moreover, we demonstrate that this immune-suppressive effect of BRs is due, at least in part, to negative cross talk with salicylic acid (SA) and gibberellic acid (GA) pathways. BR-mediated suppression of SA defenses occurred downstream of SA biosynthesis, but upstream of the master defense regulators NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 and OsWRKY45. In contrast, BR alleviated GA-directed immune responses by interfering at multiple levels with GA metabolism, resulting in indirect stabilization of the DELLA protein and central GA repressor SLENDER RICE1 (SLR1). Collectively, these data favor a model whereby P. graminicola coopts the plant BR pathway as a decoy to antagonize effectual SA- and GA-mediated defenses. Our results highlight the importance of BRs in modulating plant immunity and uncover pathogen-mediated manipulation of plant steroid homeostasis as a core virulence strategy. PMID:22353574

  11. Sci-Fri AM: Quality, Safety, and Professional Issues 02: Recent work on TQC Suite and Data from a National survey on Community Uptake

    Energy Technology Data Exchange (ETDEWEB)

    Malkoske, Kyle; Nielsen, Michelle; Brown, Erika; Diamond, Kevin; Frenière, Normand; Grant, John; Pomerleau-Dalcourt, Natalie; Schella, Jason; Schreiner, L. John; Tantot, Laurent; Barajas, Eduardo Villareal; Sasaki, David; Milette, Marie-Pierre; Bertrand, Marie-Joëlle; Bissonnette, Jean-Pierre [Royal Victoria Hospital (Canada)

    2016-08-15

    The Canadian Partnership for Quality Radiotherapy (CPQR) and the Canadian Organization of Medical Physicist’s (COMP) Quality Assurance and Radiation Safety Advisory Committee (QARSAC) have worked together in the development of a suite of Technical Quality Control (TQC) Guidelines for radiation treatment equipment and technologies, that outline specific performance objectives and criteria that equipment should meet in order to assure an acceptable level of radiation treatment quality. Early community engagement and uptake survey data showed 70% of Canadian centers are part of this process and that the data in the guideline documents reflect, and are influencing the way Canadian radiation treatment centres run their technical quality control programs. As the TQC development framework matured as a cross-country initiative, guidance documents have been developed in many clinical technologies. Recently, there have been new TQC documents initiated for Gamma Knife and Cyberknife technologies where the entire communities within Canada are involved in the review process. At the same time, QARSAC reviewed the suite as a whole for the first time and it was found that some tests and tolerances overlapped across multiple documents as single tests could pertain to multiple quality control areas. The work to streamline the entire suite has allowed for improved usability of the suite while keeping the integrity of single quality control areas. The suite will be published by the JACMP, in the coming year.

  12. Sci-Fri AM: Quality, Safety, and Professional Issues 02: Recent work on TQC Suite and Data from a National survey on Community Uptake

    International Nuclear Information System (INIS)

    Malkoske, Kyle; Nielsen, Michelle; Brown, Erika; Diamond, Kevin; Frenière, Normand; Grant, John; Pomerleau-Dalcourt, Natalie; Schella, Jason; Schreiner, L. John; Tantot, Laurent; Barajas, Eduardo Villareal; Sasaki, David; Milette, Marie-Pierre; Bertrand, Marie-Joëlle; Bissonnette, Jean-Pierre

    2016-01-01

    The Canadian Partnership for Quality Radiotherapy (CPQR) and the Canadian Organization of Medical Physicist’s (COMP) Quality Assurance and Radiation Safety Advisory Committee (QARSAC) have worked together in the development of a suite of Technical Quality Control (TQC) Guidelines for radiation treatment equipment and technologies, that outline specific performance objectives and criteria that equipment should meet in order to assure an acceptable level of radiation treatment quality. Early community engagement and uptake survey data showed 70% of Canadian centers are part of this process and that the data in the guideline documents reflect, and are influencing the way Canadian radiation treatment centres run their technical quality control programs. As the TQC development framework matured as a cross-country initiative, guidance documents have been developed in many clinical technologies. Recently, there have been new TQC documents initiated for Gamma Knife and Cyberknife technologies where the entire communities within Canada are involved in the review process. At the same time, QARSAC reviewed the suite as a whole for the first time and it was found that some tests and tolerances overlapped across multiple documents as single tests could pertain to multiple quality control areas. The work to streamline the entire suite has allowed for improved usability of the suite while keeping the integrity of single quality control areas. The suite will be published by the JACMP, in the coming year.

  13. The UEA sRNA Workbench (version 4.4): a comprehensive suite of tools for analyzing miRNAs and sRNAs.

    Science.gov (United States)

    Stocks, Matthew B; Mohorianu, Irina; Beckers, Matthew; Paicu, Claudia; Moxon, Simon; Thody, Joshua; Dalmay, Tamas; Moulton, Vincent

    2018-05-02

    RNA interference, a highly conserved regulatory mechanism, is mediated via small RNAs. Recent technical advances enabled the analysis of larger, complex datasets and the investigation of microRNAs and the less known small interfering RNAs. However, the size and intricacy of current data requires a comprehensive set of tools, able to discriminate the patterns from the low-level, noise-like, variation; numerous and varied suggestions from the community represent an invaluable source of ideas for future tools, the ability of the community to contribute to this software is essential. We present a new version of the UEA sRNA Workbench, reconfigured to allow an easy insertion of new tools/workflows. In its released form, it comprises of a suite of tools in a user-friendly environment, with enhanced capabilities for a comprehensive processing of sRNA-seq data e.g. tools for an accurate prediction of sRNA loci (CoLIde) and miRNA loci (miRCat2), as well as workflows to guide the users through common steps such as quality checking of the input data, normalization of abundances or detection of differential expression represent the first step in sRNA-seq analyses. The UEA sRNA Workbench is available at: http://srna-workbench.cmp.uea.ac.uk The source code is available at: https://github.com/sRNAworkbenchuea/UEA_sRNA_Workbench. v.moulton@uea.ac.uk.

  14. Metabolic Diet App Suite for inborn errors of amino acid metabolism.

    Science.gov (United States)

    Ho, Gloria; Ueda, Keiko; Houben, Roderick F A; Joa, Jeff; Giezen, Alette; Cheng, Barbara; van Karnebeek, Clara D M

    2016-03-01

    An increasing number of rare inborn errors of metabolism (IEMs) are amenable to targeted metabolic nutrition therapy. Daily adherence is important to attain metabolic control and prevent organ damage. This is challenging however, given the lack of information of disorder specific nutrient content of foods, the limited availability and cost of specialty products as well as difficulties in reliable calculation and tracking of dietary intake and targets. To develop apps for all inborn errors of amino acid metabolism for which the mainstay of treatment is a medical diet, and obtain patient and family feedback throughout the process to incorporate this into subsequent versions. The Metabolic Diet App Suite was created with input from health care professionals as a free, user-friendly, online tool for both mobile devices and desktop computers (http://www.metabolicdietapp.org) for 15 different IEMs. General information is provided for each IEM with links to useful online resources. Nutrient information is based on the MetabolicPro™, a North American food database compiled by the Genetic Metabolic Dietitians International (GMDI) Technology committee. After user registration, a personalized dashboard and management plan including specific nutrient goals are created. Each Diet App has a user-friendly interface and the functions include: nutrient intake counts, adding your own foods and homemade recipes and, managing a daily food diary. Patient and family feedback was overall positive and specific suggestions were used to further improve the App Suite. The Metabolic Diet App Suite aids individuals affected by IEMs to track and plan their meals. Future research should evaluate its impact on patient adherence, metabolic control, quality of life and health-related outcomes. The Suite will be updated and expanded to Apps for other categories of IEMs. Finally, this Suite is a support tool only, and does not replace medical/metabolic nutrition professional advice. Copyright

  15. The relationship between personality traits and anxiety/depression levels in different drug abusers' groups

    Directory of Open Access Journals (Sweden)

    Tatalović Vorkapić Sanja

    2013-12-01

    Full Text Available AIM: Since psychosocial characteristics of drug abuse involve mainly specific personality and emotional changes, it is very important to investigate characteristics of addictive personality in relationship with emotional state of the individual. Considering that, the objective of this study was to analyse the relationship between personality structure and emotional state of two different groups: heroin addicts and recreate drug abusers. METHODS: The total of 288 (219 males and 69 females; 191 heroin addicts and 97 recreate drug users clients of Centre for the prevention and treatment of drug abuse in Rijeka completed Eysenck's Personality Questionnaire (EPQ R/A, Beck's Anxiety Inventory (BAI and Beck's Depression Inventory (BDI. Their average age was 22. RESULTS: In the group of heroin addicts, higher levels of anxiety and depression were significantly correlated with higher levels of psychoticism, neuroticism, criminality and addiction. In the group of recreate drug users, higher extraversion and social conformity were determined. Furthermore, in the first group was found even higher depression. However when the anxiety level was compared between these two groups, there was no significant difference. CONCLUSION: Overall, the findings implied that the used measurement instruments could serve as the useful diagnostic tools that could ensure advantageous treatment directions.

  16. Geophysical characterization from Itu intrusive suite

    International Nuclear Information System (INIS)

    Pascholati, M.E.

    1989-01-01

    The integrated use of geophysical, geological, geochemical, petrographical and remote sensing data resulted in a substantial increase in the knowledge of the Itu Intrusive Suite. The main geophysical method was gamma-ray spectrometry together with fluorimetry and autoradiography. Three methods were used for calculation of laboratory gamma-ray spectrometry data. For U, the regression method was the best one. For K and Th, equations system and absolute calibration presented the best results. Surface gamma-ray spectrometry allowed comparison with laboratory data and permitted important contribution to the study of environmental radiation. (author)

  17. Immunoglobulin E-mediated sensitization to pine and beech dust in relation to wood dust exposure levels and respiratory symptoms in the furniture industry.

    Science.gov (United States)

    Schlünssen, Vivi; Kespohl, Sabine; Jacobsen, Gitte; Raulf-Heimsoth, Monika; Schaumburg, Inger; Sigsgaard, Torben

    2011-03-01

    Wood dust exposure may cause Immunoglobulin E (IgE)-mediated allergic diseases. Our objectives were to estimate pine and beech dust sensitization rates among woodworkers and a reference group, explore the association between exposure and sensitization and between sensitization and respiratory symptoms, and finally investigate the impact of proteinogenic specific IgE (sIgE) epitopes on respiratory symptoms. In a Danish study among 52 furniture factories and 2 reference factories, we evaluated the workers' asthma and rhinitis status using questionnaires and blood samples collected from 1506 woodworkers and 195 references. Workers with asthma symptoms (N=298), a random study sample (N=399) and a random rhinitis sample (N=100) were evaluated for IgE-mediated sensitization to pine and beech dust. The prevalence of pine and beech sensitization among current woodworkers was 1.7 and 3.1%, respectively. No differences in sensitization rates were found between woodworkers and references, but the prevalence of wood dust sensitization was dose-dependently associated with the current level of wood dust exposure. No relation was observed between wood dust sensitization per se and respiratory symptoms. Only symptomatic subjects had proteinogenic IgE epitopes to pine. Increased odds ratios for sIgE based on proteinogenic epitopes to beech and respiratory symptoms were found, although they were not statistically significant. Sensitization rates to pine and beech were the same for woodworkers and references but dependent on the current wood dust exposure level. The importance of beech and pine wood sensitization is limited, but may be of clinical significance for a few workers if the IgE epitopes are proteinogenic.

  18. Potential of a suite of robot/computer-assisted motivating systems for personalized, home-based, stroke rehabilitation

    Directory of Open Access Journals (Sweden)

    Feng Xin

    2007-03-01

    Full Text Available Abstract Background There is a need to improve semi-autonomous stroke therapy in home environments often characterized by low supervision of clinical experts and low extrinsic motivation. Our distributed device approach to this problem consists of an integrated suite of low-cost robotic/computer-assistive technologies driven by a novel universal access software framework called UniTherapy. Our design strategy for personalizing the therapy, providing extrinsic motivation and outcome assessment is presented and evaluated. Methods Three studies were conducted to evaluate the potential of the suite. A conventional force-reflecting joystick, a modified joystick therapy platform (TheraJoy, and a steering wheel platform (TheraDrive were tested separately with the UniTherapy software. Stroke subjects with hemiparesis and able-bodied subjects completed tracking activities with the devices in different positions. We quantify motor performance across subject groups and across device platforms and muscle activation across devices at two positions in the arm workspace. Results Trends in the assessment metrics were consistent across devices with able-bodied and high functioning strokes subjects being significantly more accurate and quicker in their motor performance than low functioning subjects. Muscle activation patterns were different for shoulder and elbow across different devices and locations. Conclusion The Robot/CAMR suite has potential for stroke rehabilitation. By manipulating hardware and software variables, we can create personalized therapy environments that engage patients, address their therapy need, and track their progress. A larger longitudinal study is still needed to evaluate these systems in under-supervised environments such as the home.

  19. Statutes of limitations: the special problem of DES suits

    International Nuclear Information System (INIS)

    Feigin, C.A.

    1981-01-01

    In 1971, medical studies determined that DES causes a rare type of vaginal cancer in a small number of daughters of mothers who took DES during pregnancy. Subsequently, medical studies determined that exposure to DES can cause other vaginal abnormalities in the daughters, some of which may be precancerous. As a result of these discoveries, many lawsuits have been filed by these daughters against DES manufacturers. Many DES suits may be barred by statutes of limitations, both because the number of years between the daughters' exposure to DES in utero and the discovery that DES can cause injuries exceeds the statutory period, and because the cancer or other injuries caused by DES may not develop for many additional years. This Note discusses two methods that DES plaintiffs may be able to use to overcome the potential statutes of limitations bar: the discovery rule, and state provisions which toll the statute of limitations for minors. The Note contends that courts should apply an expanded discovery rule to DES suits to avoid the unfair result of barring a claim before the plaintiff could have known that she had a cause of action. In addition, the Note argues that the injury which causes the statute of limitations to begin to run in DES suits should not be rigidly defined. Finally, the Note urges that courts allow eligible DES plaintiffs to take advantage of applicable state provisions that toll the statute of limitations for minors

  20. Miniature Flexible Humidity Sensitive Patches for Space Suits, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced space suit technologies demand improved, simplified, long-life regenerative sensing technologies, including humidity sensors, that exceed the performance of...

  1. CAMEO (Computer-Aided Management of Emergency Operations) Software Suite

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CAMEO is the umbrella name for a system of software applications used widely to plan for and respond to chemical emergencies. All of the programs in the suite work...

  2. Arensky. Silhouettes (Suite N 2), Op. 23 / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1991-01-01

    Uuest heliplaadist "Arensky. Silhouettes (Suite N 2), Op. 23. Scrjabin. Symphony N 3 in C minor, Op. 43 "Le divin poeme". Danish National Radio Symphony Orchestra. Neeme Järvi. Chandos cassette ABTD 1509; CD CHAN 8898 (66 minutes)

  3. Rimsky-Korsakov: Symphony N2 (Symphonic Suite) / Warrack, John

    Index Scriptorium Estoniae

    Warrack, John

    1990-01-01

    Uuest heliplaadist "Rimsky-Korsakov: Symphony N2 (Symphonic Suite), Op. 9, "Antar" Russian Easter Festival Overture, Op.36. Philharmonia Orchestra, Evgeni Svetlanov. Hyperion KA 66399. CDA 66399. Teise sümfoonia esitust võrreldud Neeme Järvi plaadistusega

  4. Development and Evaluation of a Mobile Application Suite for Enhancing the Social Inclusion and Well-Being of Seniors

    Directory of Open Access Journals (Sweden)

    Christos Goumopoulos

    2017-06-01

    Full Text Available Smart mobile devices, due to their ubiquitous nature and high level penetration in everyday life, can be a key component of an Ambient Assisted Living system to improve the quality of life of older people. This paper presents the development and evaluation of Senior App Suite, a system created for assisting seniors’ personal independence and social inclusion. The system integrates mobile computing combined with web and service-oriented technologies to offer a mobile application suite that seniors can easily use to access services, spanning various application areas such as social networking, emergency detection and overall well-being. The research hypothesis is that using such services can be beneficial for decreasing social isolation. There is quantitative indication that this assumption is realistic backed up also by the qualitative analysis from the user’s feedback derived during a pilot study (n = 22 suggesting that Senior App Suite can motivate people in new activities, maintain connection with social ties, give joy and self-confidence, and increase the frequency and quality of social interactions. Our contribution is a detailed methodology spanning the research, design, development, and evaluation of a solution that aims to improve the quality of life of seniors while addressing open issues identified in related initiatives.

  5. STS-90 Pilot Scott Altman is suited up for launch

    Science.gov (United States)

    1998-01-01

    STS-90 Pilot Scott Altman is assisted during suit-up activities by Lockheed Suit Technician Valerie McNeil from Johnson Space Center in KSC's Operations and Checkout Building. Altman and the rest of the STS-90 crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. His first trip into space, Altman is participating in a life sciences research flight that will focus on the most complex and least understood part of the human body - - the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body.

  6. Erythrocyte enzymes in groups of Rattus norvegicus with genetic differences in 2,3-diphosphoglycerate levels.

    Science.gov (United States)

    Noble, N A; Tanaka, K R

    1979-01-01

    1. A major locus with two alleles is responsible for large differences in erythrocyte 2,3-diphosphoglycerate (DPG) levels in Rattus norvegicus. Blood from homozygous High-DPG, homozygous Low-DPG and heterozygous animals was used to measure blood indices and red cell enzyme activities. 2. Significant differences between groups were found in DPG levels, white blood cell counts and hemoglobin levels. 3. The results suggest that none of the red cell enzymes assayed is structurally or quantitatively different in the three groups.

  7. The effect of α1 -adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea level and high altitude.

    Science.gov (United States)

    Tymko, Michael M; Tremblay, Joshua C; Hansen, Alex B; Howe, Connor A; Willie, Chris K; Stembridge, Mike; Green, Daniel J; Hoiland, Ryan L; Subedi, Prajan; Anholm, James D; Ainslie, Philip N

    2017-03-01

    Our objective was to quantify endothelial function (via brachial artery flow-mediated dilatation) at sea level (344 m) and high altitude (3800 m) at rest and following both maximal exercise and 30 min of moderate-intensity cycling exercise with and without administration of an α 1 -adrenergic blockade. Brachial endothelial function did not differ between sea level and high altitude at rest, nor following maximal exercise. At sea level, endothelial function decreased following 30 min of moderate-intensity exercise, and this decrease was abolished with α 1 -adrenergic blockade. At high altitude, endothelial function did not decrease immediately after 30 min of moderate-intensity exercise, and administration of α 1 -adrenergic blockade resulted in an increase in flow-mediated dilatation. Our data indicate that post-exercise endothelial function is modified at high altitude (i.e. prolonged hypoxaemia). The current study helps to elucidate the physiological mechanisms associated with high-altitude acclimatization, and provides insight into the relationship between sympathetic nervous activity and vascular endothelial function. We examined the hypotheses that (1) at rest, endothelial function would be impaired at high altitude compared to sea level, (2) endothelial function would be reduced to a greater extent at sea level compared to high altitude after maximal exercise, and (3) reductions in endothelial function following moderate-intensity exercise at both sea level and high altitude are mediated via an α 1 -adrenergic pathway. In a double-blinded, counterbalanced, randomized and placebo-controlled design, nine healthy participants performed a maximal-exercise test, and two 30 min sessions of semi-recumbent cycling exercise at 50% peak output following either placebo or α 1 -adrenergic blockade (prazosin; 0.05 mg kg  -1 ). These experiments were completed at both sea-level (344 m) and high altitude (3800 m). Blood pressure (finger photoplethysmography

  8. Integrated Instrument Simulator Suites for Earth Science

    Science.gov (United States)

    Tanelli, Simone; Tao, Wei-Kuo; Matsui, Toshihisa; Hostetler, Chris; Hair, John; Butler, Carolyn; Kuo, Kwo-Sen; Niamsuwan, Noppasin; Johnson, Michael P.; Jacob, Joseph C.; hide

    2012-01-01

    The NASA Earth Observing System Simulators Suite (NEOS3) is a modular framework of forward simulations tools for remote sensing of Earth's Atmosphere from space. It was initiated as the Instrument Simulator Suite for Atmospheric Remote Sensing (ISSARS) under the NASA Advanced Information Systems Technology (AIST) program of the Earth Science Technology Office (ESTO) to enable science users to perform simulations based on advanced atmospheric and simple land surface models, and to rapidly integrate in a broad framework any experimental or innovative tools that they may have developed in this context. The name was changed to NEOS3 when the project was expanded to include more advanced modeling tools for the surface contributions, accounting for scattering and emission properties of layered surface (e.g., soil moisture, vegetation, snow and ice, subsurface layers). NEOS3 relies on a web-based graphic user interface, and a three-stage processing strategy to generate simulated measurements. The user has full control over a wide range of customizations both in terms of a priori assumptions and in terms of specific solvers or models used to calculate the measured signals.This presentation will demonstrate the general architecture, the configuration procedures and illustrate some sample products and the fundamental interface requirements for modules candidate for integration.

  9. Ergonomic assessment of neck posture in the minimally invasive surgery suite during laparoscopic cholecystectomy.

    Science.gov (United States)

    van Det, M J; Meijerink, W J H J; Hoff, C; van Veelen, M A; Pierie, J P E N

    2008-11-01

    With the expanding implementation of minimally invasive surgery, the operating team is confronted with challenges in the field of ergonomics. Visual feedback is derived from a monitor placed outside the operating field. This crossover trial was conducted to evaluate and compare neck posture in relation to monitor position in a dedicated minimally invasive surgery (MIS) suite and a conventional operating room. Assessment of the neck was conducted for 16 surgeons, assisting surgeons, and scrub nurses performing a laparoscopic cholecystectomy in both types of operating room. Flexion and rotation of the cervical spine were measured intraoperatively using a video analysis system. A two-question visual analog scale (VAS) questionnaire was used to evaluate posture in relation to the monitor position. Neck rotation was significantly reduced in the MIS suite for the surgeon (p = 0.018) and the assisting surgeon (p < 0.001). Neck flexion was significantly improved in the MIS suite for the surgeon (p < 0.001) and the scrub nurse (p = 0.018). On the questionnaire, the operating room team scored their posture significantly higher in the MIS suite and also indicated fewer musculoskeletal complaints. The ergonomic quality of the neck posture is significantly improved in the MIS suite for the entire operating room team.

  10. The PAUL Suit(©) : an experience of ageing.

    Science.gov (United States)

    Bennett, Paul; Moore, Malcolm; Wenham, John

    2016-04-01

    An ageing population worldwide makes it increasingly important that health students understand issues that elderly people face and can provide empathic care to them. This teaching department in an isolated rural setting developed an interprofessional learning session to assist health students to understand issues of functional loss and social isolation that can affect elderly people. The Premature Ageing Unisex Leisure (PAUL) Suit(©) was developed as part of a 1-day learning session for undergraduate health students - including students of medicine, nursing and allied health - attending clinical placement in far-west New South Wales. The suit was developed locally and can be adjusted to simulate a wide range of functional losses in the wearer. Students undertake a range of daily tasks in the community while wearing the suit in the company of a student 'carer'. Over the past 4 years, approximately 140 students have participated in the simulation. Post-simulation evaluations report that students gain a greater understanding of some functional issues associated with ageing, and of the social isolation that can be associated with these. The experiential nature of the activity leads to some powerful insights. This activity is an innovative, experiential tool to deepen students understanding of issues related to ageing This activity is an innovative, experiential tool to deepen students understanding of issues relating to ageing. The interprofessional nature of the activity is an important factor in the success of the day, and produces a wide range of shared insights. The activity also enhances the partnerships between the university, the health service and the local community. Our experience supports the value of simulation in providing a deep learning opportunity in the area of ageing and disability. © 2015 John Wiley & Sons Ltd.

  11. Oral Computer-Mediated Interaction Between L2 Learners: It’s About Time!

    Directory of Open Access Journals (Sweden)

    Yanguas, Íñigo

    2010-10-01

    Full Text Available This study explores task-based, synchronous oral computer-mediated communication (CMC among intermediate-level learners of Spanish. In particular, this paper examines (a how learners in video and audio CMC groups negotiate for meaning during task-based interaction, (b possible differences between both oral CMC modes and traditional face-to-face (FTF communication, and (c how this oral computer mediated negotiation compares to that found in the text-based CMC literature. Fifteen learner-to-learner dyads were randomly assigned to an audio group, a video group, and a FTF control group to complete a jigsaw task that was seeded with 16 unknown lexical items. Experimental groups used Skype, free online communication software, to carry out the task. The transcripts of the conversations reveal that oral CMC groups do indeed negotiate for meaning in this multimedia context when non-understanding occurs between speakers. In addition, results showed differences in the way audio and video groups carry out these negotiations, which were mainly due to the lack of visual contact in the audio group. No differences were found between video and FTF groups. Furthermore, oral CMC turn-taking patterns were shown to be very similar to FTF patterns but opposite to those found in written synchronous CMC. Oral CMC interaction patterns are shown to be more versatile.

  12. Academic Procrastination and the Performance of Graduate-Level Cooperative Groups in Research Methods Courses

    Science.gov (United States)

    Jiao, Qun G.; DaRos-Voseles, Denise A.; Collins, Kathleen M. T.; Onwuegbuzie, Anthony J.

    2011-01-01

    This study examined the extent to which academic procrastination predicted the performance of cooperative groups in graduate-level research methods courses. A total of 28 groups was examined (n = 83 students), ranging in size from 2 to 5 (M = 2.96, SD = 1.10). Multiple regression analyses revealed that neither within-group mean nor within-group…

  13. Development of the DL/H-1 full pressure suit for private spaceflight

    Science.gov (United States)

    León, Pablo de; Harris, Gary L.

    2010-06-01

    The objective of this paper is to detail the need for full pressure suits to protect spaceflight participants during the experimental phases of flight testing of new space vehicles. It also details the objectives, historical background, basis for design, problems encountered by the designers and final development of the DL/H-1 full pressure suit. It will include justification for its use and results of the initial tests in the high altitude chamber and spacecraft simulator at the J.D. Odegard School of Aerospace Sciences at the University of North Dakota. For the test flights of early commercial space vehicles and tourist suborbital spacecrafts, emergency protection from the rarified air of the upper atmosphere and the vacuum of low Earth orbit almost certainly will be a requirement. Suborbital vehicles could be operating in "space equivalent conditions" for as long as 30 min to as much as several hours. In the case of cabin pressure loss, without personal protection, catastrophic loss of crew and vehicle could result. This paper explains the different steps taken by the authors who designed and built a preflight hardware pressure suit that can meet the physiological and comfort requirements of the tourist suborbital industry and the early commercial private spaceflight community. The suborbital tourist and commercial spaceflight industry have unique problems confronting the pressure suit builder such as unpressurized comfort, reasonable expense, unique sizing of the general population, decompression complications of persons not fitting a past military physiology profile and equipment weight issues. In addition, the lack of a certifying agency or guidance from international or national aviation authorities has created the opportunity for the emerging civilian pressure suit industry to create a new safety standard by which it can regulate itself in the same way the recreational SCUBA diving industry has since the late 1950s.

  14. Human skin in vitro permeation of bentazon and isoproturon formulations with or without protective clothing suit.

    Science.gov (United States)

    Berthet, Aurélie; Hopf, Nancy B; Miles, Alexandra; Spring, Philipp; Charrière, Nicole; Garrigou, Alain; Baldi, Isabelle; Vernez, David

    2014-01-01

    Skin exposures to chemicals may lead, through percutaneous permeation, to a significant increase in systemic circulation. Skin is the primary route of entry during some occupational activities, especially in agriculture. To reduce skin exposures, the use of personal protective equipment (PPE) is recommended. PPE efficiency is characterized as the time until products permeate through material (lag time, Tlag). Both skin and PPE permeations are assessed using similar in vitro methods; the diffusion cell system. Flow-through diffusion cells were used in this study to assess the permeation of two herbicides, bentazon and isoproturon, as well as four related commercial formulations (Basagran(®), Basamais(®), Arelon(®) and Matara(®)). Permeation was measured through fresh excised human skin, protective clothing suits (suits) (Microchem(®) 3000, AgriSafe Pro(®), Proshield(®) and Microgard(®) 2000 Plus Green), and a combination of skin and suits. Both herbicides, tested by itself or as an active ingredient in formulations, permeated readily through human skin and tested suits (Tlag < 2 h). High permeation coefficients were obtained regardless of formulations or tested membranes, except for Microchem(®) 3000. Short Tlag, were observed even when skin was covered with suits, except for Microchem(®) 3000. Kp values tended to decrease when suits covered the skin (except when Arelon(®) was applied to skin covered with AgriSafe Pro and Microgard(®) 2000), suggesting that Tlag alone is insufficient in characterizing suits. To better estimate human skin permeations, in vitro experiments should not only use human skin but also consider the intended use of the suit, i.e., the active ingredient concentrations and type of formulations, which significantly affect skin permeation.

  15. Effect of Caring for an Abusive Parent on Mental Health: The Mediating Role of Self-Esteem.

    Science.gov (United States)

    Kong, Jooyoung

    2018-05-08

    This study examines a sample of filial caregivers to investigate whether and how a history of childhood abuse is associated with caregivers' mental health (i.e., depressed affect, psychological well-being, and life satisfaction). This study also investigates the mediational role of self-esteem between caring for an abusive parent and the mental health outcomes. Using the 2004-2006 National Survey of Midlife Development in the United States, data from 219 filial caregivers were analyzed. A series of ordinary least squares (OLS) regression and mediational analyses were conducted to estimate the direct and indirect effects of providing care to an abusive parent on negative affect, psychological well-being, and levels of life satisfaction. Key results showed that providing care to an abusive parent was associated with greater depressed affect and lower levels of life satisfaction. In addition, self-esteem served as a significant mediator: providing care to an abusive parent was associated with lower self-esteem, which was, in turn, ultimately associated with greater depressed affect, diminished psychological well-being, and lower levels of life satisfaction. Filial caregivers with a history of childhood abuse should be acknowledged as a high-risk group of caregivers so that they can gain attention and support for targeted interventions. Additionally, evidence-based intervention programs (e.g., improving self-esteem issues) should be designed and implemented to address this group's unique challenges and concerns.

  16. Causal relationship between the AHSG gene and BMD through fetuin-A and BMI: multiple mediation analysis.

    Science.gov (United States)

    Sritara, C; Thakkinstian, A; Ongphiphadhanakul, B; Chailurkit, L; Chanprasertyothin, S; Ratanachaiwong, W; Vathesatogkit, P; Sritara, P

    2014-05-01

    Using mediation analysis, a causal relationship between the AHSG gene and bone mineral density (BMD) through fetuin-A and body mass index (BMI) mediators was suggested. Fetuin-A, a multifunctional protein of hepatic origin, is associated with bone mineral density. It is unclear if this association is causal. This study aimed at clarification of this issue. A cross-sectional study was conducted among 1,741 healthy workers from the Electricity Generating Authority of Thailand (EGAT) cohort. The alpha-2-Heremans-Schmid glycoprotein (AHSG) rs2248690 gene was genotyped. Three mediation models were constructed using seemingly unrelated regression analysis. First, the ln[fetuin-A] group was regressed on the AHSG gene. Second, the BMI group was regressed on the AHSG gene and the ln[fetuin-A] group. Finally, the BMD model was constructed by fitting BMD on two mediators (ln[fetuin-A] and BMI) and the independent AHSG variable. All three analyses were adjusted for confounders. The prevalence of the minor T allele for the AHSG locus was 15.2%. The AHSG locus was highly related to serum fetuin-A levels (P Multiple mediation analyses showed that AHSG was significantly associated with BMD through the ln[fetuin-A] and BMI pathway, with beta coefficients of 0.0060 (95% CI 0.0038, 0.0083) and 0.0030 (95% CI 0.0020, 0.0045) at the total hip and lumbar spine, respectively. About 27.3 and 26.0% of total genetic effects on hip and spine BMD, respectively, were explained by the mediation effects of fetuin-A and BMI. Our study suggested evidence of a causal relationship between the AHSG gene and BMD through fetuin-A and BMI mediators.

  17. Music, radio and mediatization

    DEFF Research Database (Denmark)

    Michelsen, Morten; Krogh, Mads

    2016-01-01

    of mediatization where media as such seem to be ascribed agency. Instead, we consider historical accounts of music–radio in order to address the complex nonlinearity of concrete processes of mediatization as they take place in the multiple meetings between a decentred notion of radio and musical life.......Mediatization has become a key concept for understanding the relations between media and other cultural and social fields. Contributing to the discussions related to the concept of mediatization, this article discusses how practices of radio and music(al life) influence each other. We follow Deacon......’s and Stanyer’s advice to supplement the concept of mediatization with ‘a series of additional concepts at lower levels of abstraction’ and suggest, in this respect, the notion of heterogeneous milieus of music–radio. Hereby, we turn away from the all-encompassing perspectives related to the concept...

  18. Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.

    Directory of Open Access Journals (Sweden)

    Maxim Pilyugin

    Full Text Available Histone chaperones are at the hub of a diverse interaction networks integrating a plethora of chromatin modifying activities. Histone H3/H4 chaperone ASF1 is a target for cell-cycle regulated Tousled-like kinases (TLKs and both proteins cooperate during chromatin replication. However, the precise role of post-translational modification of ASF1 remained unclear. Here, we identify the TLK phosphorylation sites for both Drosophila and human ASF1 proteins. Loss of TLK-mediated phosphorylation triggers hASF1a and dASF1 degradation by proteasome-dependent and independent mechanisms respectively. Consistent with this notion, introduction of phosphorylation-mimicking mutants inhibits hASF1a and dASF1 degradation. Human hASF1b is also targeted for proteasome-dependent degradation, but its stability is not affected by phosphorylation indicating that other mechanisms are likely to be involved in control of hASF1b levels. Together, these results suggest that ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.

  19. The Relationship between Listening Comprehension of Text and Sentences in Preschoolers: Specific or Mediated by Lower and Higher Level Components?

    Science.gov (United States)

    Florit, Elena; Roch, Maja; Levorato, M. Chiara

    2013-01-01

    Two studies explored the relation between listening comprehension of text and listening comprehension of sentences in preschoolers aged 4 to 5 years, 11 months. The first study analyzed this relationship taking into account the role of lower level components, namely, word knowledge and verbal working memory, as possible mediators. These components…

  20. Nonventing Thermal and Humidity Control for EVA Suits, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Future manned space exploration missions will require space suits with capabilities beyond the current state of the art. Portable Life Support Systems for these...

  1. Dynamic Human-Centered Suit Design: A Computational and Experimental Method

    Data.gov (United States)

    National Aeronautics and Space Administration — Introduction: Manned space flight necessitates an ability to provide life support to crewmembers during multiple mission stages, in the form of space suits. With...

  2. The Bucket System – A computer mediated signaling system for group improvisation

    DEFF Research Database (Denmark)

    Dahlstedt, Palle; Nilsson, Per Anders; Robair, Gino

    2015-01-01

    The Bucket System is a new system for computer-mediated ensemble improvisation, designed by improvisers for improvisers. Coming from a tradition of structured free ensemble improvisation practices (comprovisation), influenced by post-WW2 experimental music practices, it is a signaling system...

  3. Effects of cadmium on olfactory mediated behaviors and molecular biomarkers in coho salmon (Oncorhynchus kisutch)

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Chase R.; Gallagher, Evan P., E-mail: evang3@u.washington.edu

    2013-09-15

    Highlights: •Low Cd exposures elicited significant olfactory mediated behavioral changes independent of histological injury. •The olfactory behavioral deficits persisted following a 16-day depuration. •Olfactory molecular biomarkers expression was strongly linked to injury to the olfactory epithelium. •Cd induced a strong antioxidant response in the coho salmon olfactory system. •Results suggest a sensitivity of salmonids to waterborne Cd. -- Abstract: The olfactory system of salmonids is sensitive to the adverse effects of metals such as copper and cadmium. In the current study, we analyzed olfactory-mediated alarm responses, epithelial injury and recovery, and a suite of olfactory molecular biomarkers encoding genes critical in maintaining olfactory function in juvenile coho salmon receiving acute exposures to cadmium (Cd). The molecular biomarkers analyzed included four G-protein coupled receptors (GPCRs) representing the two major classes of odorant receptors (salmon olfactory receptor sorb and vomeronasal receptors svra, svrb, and gpr27), as well as markers of neurite outgrowth (nrn1) and antioxidant responses to metals, including heme oxygenase 1 (hmox1), and peroxiredoxin 1 (prdx1). Coho received acute (8–168 h) exposures to 3.7 ppb and 347 ppb Cd, and a subset of fish was analyzed following a 16-day depuration. Coho exposed to 347 ppb Cd over 48 h exhibited a reduction in freeze responses, and an extensive loss of olfaction accompanied by histological injury to the olfactory epithelium. The olfactory injury in coho exposed to 347 ppb Cd was accompanied at the gene level by significant decreases in expression of the olfactory GPCRs and increased expression of hmox1. Persistent behavioral deficits, histological injury and altered expression of a subset of olfactory biomarkers were still evident in Cd-exposed coho following a 16-day depuration in clean water. Exposure to 3.7 ppb Cd also resulted in reduced freeze responses and histological changes

  4. The shielded chemistry suite at BNL and its use in the study of the irradiated uranium-water reaction

    International Nuclear Information System (INIS)

    Bannister, G.H.; Tyfield, S.P.

    1977-11-01

    A versatile shielded facility for chemical studies is now in use at Berkeley Nuclear Laboratories. The suite was fully commissioned in 1976 and first utilised to study the aqueous corrosion of irradiated reactor grade uranium. The suite consists of three adjacent interconnected cells; a balance cell, a preparation cell and an experimental cell. The development, design and layout of the facilities are described, as are the details of the equipment installed to undertake a uranium corrosion study. The preparation cell is used for procedures that could results in high levels of contamination, such as cutting of uranium specimens. The uranium samples are corroded in sealed steel capsules installed in the experimental cell. The capsules are heated either isothermally or through a transient and the reaction monitored with a pressure transducer which records the rate of hydrogen evolution from the uranium-water reaction. The experimental results will be reported elsewhere. (author)

  5. Widespread recent increases in county-level heart disease mortality across age groups.

    Science.gov (United States)

    Vaughan, Adam S; Ritchey, Matthew D; Hannan, Judy; Kramer, Michael R; Casper, Michele

    2017-12-01

    Recent national trends show decelerating declines in heart disease mortality, especially among younger adults. National trends may mask variation by geography and age. We examined recent county-level trends in heart disease mortality by age group. Using a Bayesian statistical model and National Vital Statistics Systems data, we estimated overall rates and percent change in heart disease mortality from 2010 through 2015 for four age groups (35-44, 45-54, 55-64, and 65-74 years) in 3098 US counties. Nationally, heart disease mortality declined in every age group except ages 55-64 years. County-level trends by age group showed geographically widespread increases, with 52.3%, 58.5%, 69.1%, and 42.0% of counties experiencing increases with median percent changes of 0.6%, 2.2%, 4.6%, and -1.5% for ages 35-44, 45-54, 55-64, and 65-74 years, respectively. Increases were more likely in counties with initially high heart disease mortality and outside large metropolitan areas. Recent national trends have masked local increases in heart disease mortality. These increases, especially among adults younger than age 65 years, represent challenges to communities across the country. Reversing these trends may require intensification of primary and secondary prevention-focusing policies, strategies, and interventions on younger populations, especially those living in less urban counties. Published by Elsevier Inc.

  6. ABO Blood Groups Influence Macrophage-mediated Phagocytosis of Plasmodium falciparum-infected Erythrocytes

    Science.gov (United States)

    Branch, Donald R.; Hult, Annika K.; Olsson, Martin L.; Liles, W. Conrad; Cserti-Gazdewich, Christine M.; Kain, Kevin C.

    2012-01-01

    Erythrocyte polymorphisms associated with a survival advantage to Plasmodium falciparum infection have undergone positive selection. There is a predominance of blood group O in malaria-endemic regions, and several lines of evidence suggest that ABO blood groups may influence the outcome of P. falciparum infection. Based on the hypothesis that enhanced innate clearance of infected polymorphic erythrocytes is associated with protection from severe malaria, we investigated whether P. falciparum-infected O erythrocytes are more efficiently cleared by macrophages than infected A and B erythrocytes. We show that human macrophages in vitro and mouse monocytes in vivo phagocytose P. falciparum-infected O erythrocytes more avidly than infected A and B erythrocytes and that uptake is associated with increased hemichrome deposition and high molecular weight band 3 aggregates in infected O erythrocytes. Using infected A1, A2, and O erythrocytes, we demonstrate an inverse association of phagocytic capacity with the amount of A antigen on the surface of infected erythrocytes. Finally, we report that enzymatic conversion of B erythrocytes to type as O before infection significantly enhances their uptake by macrophages to observed level comparable to that with infected O wild-type erythrocytes. These data provide the first evidence that ABO blood group antigens influence macrophage clearance of P. falciparum-infected erythrocytes and suggest an additional mechanism by which blood group O may confer resistance to severe malaria. PMID:23071435

  7. Asteroid Redirect Crewed Mission Space Suit and EVA System Architecture Trade Study

    Science.gov (United States)

    Bowie, Jonathan T.; Blanco, Raul A.; Watson, Richard D.; Kelly, Cody; Buffington, Jesse; Sipila, Stephanie A.

    2014-01-01

    This paper discusses the Asteroid Redirect Crewed Mission (ARCM) space suit and Extravehicular Activity (EVA) architecture trade study and the current state of the work to mature the requirements and products to the mission concept review level. The mission requirements and the resulting concept of operations will be discussed. A historical context will be presented as to present the similarities and differences from previous NASA missions. That will set the stage for the trade study where all options for both pressure garment and life support were considered. The rationale for the architecture decisions will then be presented. Since the trade study did identity risks, the subsequent tests and analyses that mitigated the risks will be discussed. Lastly, the current state of the effort will be provided.

  8. Do Perceptions of Competence Mediate The Relationship Between Fundamental Motor Skill Proficiency and Physical Activity Levels of Children in Kindergarten?

    Science.gov (United States)

    Crane, Jeff R; Naylor, Patti J; Cook, Ryan; Temple, Viviene A

    2015-07-01

    Perceptions of competence mediate the relationship between motor skill proficiency and physical activity among older children and adolescents. This study examined kindergarten children's perceptions of physical competence as a mediator of the relationship between motor skill proficiency as a predictor variable and physical activity levels as the outcome variable; and also with physical activity as a predictor and motor skill proficiency as the outcome. Participants were 116 children (mean age = 5 years 7 months, 58% boys) from 10 schools. Motor skills were measured using the Test of Gross Motor Development-2 and physical activity was monitored through accelerometry. Perceptions of physical competence were measured using The Pictorial Scale of Perceived Competence and Social Acceptance for Young Children, and the relationships between these variables were examined using a model of mediation. The direct path between object control skills and moderate-vigorous physical activity (MVPA) was significant and object control skills predicted perceived physical competence. However, perceived competence did not mediate the relationship between object control skills and MVPA. The significant relationship between motor proficiency and perceptions of competence did not in turn influence kindergarten children's participation in physical activity. These findings support concepts of developmental differences in the structure of the self-perception system.

  9. Brain mediators of the effects of noxious heat on pain.

    Science.gov (United States)

    Atlas, Lauren Y; Lindquist, Martin A; Bolger, Niall; Wager, Tor D

    2014-08-01

    Recent human neuroimaging studies have investigated the neural correlates of either noxious stimulus intensity or reported pain. Although useful, analyzing brain relationships with stimulus intensity and behavior separately does not address how sensation and pain are linked in the central nervous system. In this study, we used multi-level mediation analysis to identify brain mediators of pain--regions in which trial-by-trial responses to heat explained variability in the relationship between noxious stimulus intensity (across 4 levels) and pain. This approach has the potential to identify multiple circuits with complementary roles in pain genesis. Brain mediators of noxious heat effects on pain included targets of ascending nociceptive pathways (anterior cingulate, insula, SII, and medial thalamus) and also prefrontal and subcortical regions not associated with nociceptive pathways per se. Cluster analysis revealed that mediators were grouped into several distinct functional networks, including the following: somatosensory, paralimbic, and striatal-cerebellar networks that increased with stimulus intensity; and 2 networks co-localized with "default mode" regions in which stimulus intensity-related decreases mediated increased pain. We also identified "thermosensory" regions that responded to increasing noxious heat but did not predict pain reports. Finally, several regions did not respond to noxious input, but their activity predicted pain; these included ventromedial prefrontal cortex, dorsolateral prefrontal cortex, cerebellar regions, and supplementary motor cortices. These regions likely underlie both nociceptive and non-nociceptive processes that contribute to pain, such as attention and decision-making processes. Overall, these results elucidate how multiple distinct brain systems jointly contribute to the central generation of pain. Copyright © 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  10. Polycomb group protein-mediated repression of transcription

    DEFF Research Database (Denmark)

    Morey, Lluís; Helin, Kristian

    2010-01-01

    The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcri......The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work...... as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2....

  11. Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi / Michael Scott Rohan

    Index Scriptorium Estoniae

    Rohan, Michael Scott

    1996-01-01

    Sibelius: Karelia Suite, Op. 11. Luonnotar, Op. 70 a. Andante festivo. The Oceanides, Op. 73. King Christian II, Op. 27-Suite. Finlandia, Op. 26a. Gothenburg Symphony Orchester, Neeme Järvi. 1 CD Deutsche Grammophon 447 760-2GH (72 minutes: DDD)

  12. ASIM - an Instrument Suite for the International Space Station

    DEFF Research Database (Denmark)

    Neubert, Torsten; Crosby, B.; Huang, T.-Y.

    2009-01-01

    ASIM (Atmosphere-Space Interactions Monitor) is an instrument suite for studies of severe thunderstorms and their effects on the atmosphere and ionosphere. The instruments are designed to observe transient luminous events (TLEs)—sprites, blue jets and elves—and terrestrial gamma-ray flashes (TGFs...

  13. Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity.

    Directory of Open Access Journals (Sweden)

    Thomas Meinertz Dantoft

    Full Text Available Multiple Chemical Sensitivity (MCS is a chronic condition characterized by reports of recurrent symptoms in response to low level exposure to various chemical substances. Recent findings suggests that dysregulation of the immune system may play a role in MCS pathophysiology.The aim of this study was to examine baseline and low dose n-butanol-induced upper airway inflammatory response profiles in MCS subjects versus healthy controls.Eighteen participants with MCS and 18 age- and sex-matched healthy controls were enrolled in the study. Epithelial lining fluid was collected from the nasal cavity at three time points: baseline, within 15 minutes after being exposed to 3.7 ppm n-butanol in an exposure chamber and four hours after exposure termination. A total of 19 cytokines and chemokines were quantified. Furthermore, at baseline and during the exposure session, participants rated the perceived intensity, valence and levels of symptoms and autonomic recordings were obtained.The physiological and psychophysical measurements during the n-butanol exposure session verified a specific response in MCS individuals only. However, MCS subjects and healthy controls displayed similar upper airway inflammatory mediator profiles (P>0.05 at baseline. Likewise, direct comparison of mediator levels in the MCS group and controls after n-butanol exposure revealed no significant group differences.We demonstrate no abnormal upper airway inflammatory mediator levels in MCS subjects before or after a symptom-eliciting exposure to low dose n-butanol, implying that upper airways of MCS subjects are functionally intact at the level of cytokine and chemokine production and secretory capacity. This suggests that previous findings of increased cytokine plasma levels in MCS are unlikely to be caused by systemic priming via excessive upper airway inflammatory processes.

  14. Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity.

    Science.gov (United States)

    Dantoft, Thomas Meinertz; Skovbjerg, Sine; Andersson, Linus; Claeson, Anna-Sara; Lind, Nina; Nordin, Steven; Brix, Susanne

    2015-01-01

    Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by reports of recurrent symptoms in response to low level exposure to various chemical substances. Recent findings suggests that dysregulation of the immune system may play a role in MCS pathophysiology. The aim of this study was to examine baseline and low dose n-butanol-induced upper airway inflammatory response profiles in MCS subjects versus healthy controls. Eighteen participants with MCS and 18 age- and sex-matched healthy controls were enrolled in the study. Epithelial lining fluid was collected from the nasal cavity at three time points: baseline, within 15 minutes after being exposed to 3.7 ppm n-butanol in an exposure chamber and four hours after exposure termination. A total of 19 cytokines and chemokines were quantified. Furthermore, at baseline and during the exposure session, participants rated the perceived intensity, valence and levels of symptoms and autonomic recordings were obtained. The physiological and psychophysical measurements during the n-butanol exposure session verified a specific response in MCS individuals only. However, MCS subjects and healthy controls displayed similar upper airway inflammatory mediator profiles (P>0.05) at baseline. Likewise, direct comparison of mediator levels in the MCS group and controls after n-butanol exposure revealed no significant group differences. We demonstrate no abnormal upper airway inflammatory mediator levels in MCS subjects before or after a symptom-eliciting exposure to low dose n-butanol, implying that upper airways of MCS subjects are functionally intact at the level of cytokine and chemokine production and secretory capacity. This suggests that previous findings of increased cytokine plasma levels in MCS are unlikely to be caused by systemic priming via excessive upper airway inflammatory processes.

  15. Overview of the magnetic signatures of the Palaeoproterozoic Rustenburg Layered Suite, Bushveld Complex, South Africa

    Science.gov (United States)

    Cole, Janine; Finn, Carol A.; Webb, Susan J.

    2013-01-01

    Aeromagnetic data clearly delineate the mafic rocks of the economically significant Bushveld Igneous Complex. This is mainly due to the abundance of magnetite in the Upper Zone of the Rustenburg Layered Suite of the Bushveld, but strongly remanently magnetised rocks in the Main Zone also contribute significantly in places. In addition to delineating the extent of the magnetic rocks in the complex, the magnetic anomalies also provide information about the dip and depth of these units. The presence of varying degrees of remanent magnetisation in most of the magnetic lithologies of the Rustenburg Layered Suite complicates the interpretation of the data. The combination of available regional and high resolution airborne magnetic data with published palaeomagnetic data reveals characteristic magnetic signatures associated with the different magnetic lithologies in the Rustenburg Layered Suite. As expected, the ferrogabbros of the Upper Zone cause the highest amplitude magnetic anomalies, but in places subtle features within the Main Zone can also be detected. A marker with strong remanent magnetisation located in the Main Zone close to the contact with the Upper Zone is responsible for very high amplitude negative anomalies in the southern parts of both the eastern and western lobes of the Bushveld Complex. Prominent anomalies are not necessarily related to a specific lithology, but can result from the interaction between anomalies caused by differently magnetised bodies.The magnetic data provided substantial information at different levels of detail, ranging from contacts between zones, and layering within zones, to magnetite pipes dykes and faults that can have an impact on mine planning. Finally, simple modelling of the magnetic data supports the concept of continuous mafic rocks between the western and eastern lobes.

  16. Glucose Elevates NITRATE TRANSPORTER2.1 Protein Levels and Nitrate Transport Activity Independently of Its HEXOKINASE1-Mediated Stimulation of NITRATE TRANSPORTER2.1 Expression1[W][OPEN

    Science.gov (United States)

    de Jong, Femke; Thodey, Kate; Lejay, Laurence V.; Bevan, Michael W.

    2014-01-01

    Mineral nutrient uptake and assimilation is closely coordinated with the production of photosynthate to supply nutrients for growth. In Arabidopsis (Arabidopsis thaliana), nitrate uptake from the soil is mediated by genes encoding high- and low-affinity transporters that are transcriptionally regulated by both nitrate and photosynthate availability. In this study, we have studied the interactions of nitrate and glucose (Glc) on gene expression, nitrate transport, and growth using glucose-insensitive2-1 (gin2-1), which is defective in sugar responses. We confirm and extend previous work by showing that HEXOKINASE1-mediated oxidative pentose phosphate pathway (OPPP) metabolism is required for Glc-mediated NITRATE TRANSPORTER2.1 (NRT2.1) expression. Treatment with pyruvate and shikimate, two products derived from intermediates of the OPPP that are destined for amino acid production, restores wild-type levels of NRT2.1 expression, suggesting that metabolites derived from OPPP metabolism can, together with Glc, directly stimulate high levels of NRT2.1 expression. Nitrate-mediated NRT2.1 expression is not influenced by gin2-1, showing that Glc does not influence NRT2.1 expression through nitrate-mediated mechanisms. We also show that Glc stimulates NRT2.1 protein levels and transport activity independently of its HEXOKINASE1-mediated stimulation of NRT2.1 expression, demonstrating another possible posttranscriptional mechanism influencing nitrate uptake. In gin2-1 plants, nitrate-responsive biomass growth was strongly reduced, showing that the supply of OPPP metabolites is essential for assimilating nitrate for growth. PMID:24272701

  17. Geochemical fingerprinting of ∼2.5 Ga forearc-arc-backarc related magmatic suites in the Bastar Craton, central India

    Science.gov (United States)

    Asthana, Deepanker; Kumar, Sirish; Vind, Aditya Kumar; Zehra, Fatima; Kumar, Harshavardhan; Pophare, Anil M.

    2018-05-01

    The Pitepani volcanic suite of the Dongargarh Supergroup, central India comprises of a calc-alkaline suite and a tholeiitic suite, respectively. The rare earth element (REE) patterns, mantle normalized plots and relict clinopyroxene chemistry of the Pitepani calc-alkaline suite are akin to high-Mg andesites (HMA) and reveal remarkable similarity to the Cenozoic Setouchi HMA from Japan. The Pitepani HMAs are geochemically correlated with similar rocks in the Kotri-Dongargarh mobile belt (KDMB) and in the mafic dykes of the Bastar Craton. The rationale behind lithogeochemical correlations are that sanukitic HMAs represent fore-arc volcanism over a very limited period of time, under abnormally high temperature conditions and are excellent regional and tectonic time markers. Furthermore, the tholeiitic suites that are temporally and spatially associated with the HMAs in the KDMB and in the mafic dykes of the Bastar Craton are classified into: (a) a continental back-arc suite that are depleted in incompatible elements, and (b) a continental arc suite that are more depleted in incompatible elements, respectively. The HMA suite, the continental back-arc and continental arc suites are lithogeochemically correlated in the KDMB and in the mafic dykes of the Bastar Craton. The three geochemically distinct Neoarchaean magmatic suites are temporally and spatially related to each other and to an active continental margin. The identification of three active continental margin magmatic suites for the first time, provides a robust conceptual framework to unravel the Neoarchaean geodynamic evolution of the Bastar Craton. We propose an active continental margin along the Neoarchaen KDMB with eastward subduction coupled with slab roll back or preferably, ridge-subduction along the Central Indian Tectonic Zone (CITZ) to account for the three distinct magmatic suites and the Neoarchean geodynamic evolution of the Bastar Craton.

  18. Locus of control, self-efficacy, and the mediating effect of outcome control: predicting course-level and global outcomes in an academic context.

    Science.gov (United States)

    Au, Evelyn W M

    2015-01-01

    The current study utilizes Skinner's framework to examine the unique contributions of internal locus of control, self-efficacy, and perceived outcome control over course performance on students' academic experiences. Undergraduate students (N = 225) took part in a longitudinal study and completed two surveys (Time 1: just before their mid-term exams; Time 2: just before their final exam in the same semester). Both locus of control and self-efficacy at Time 1 predicted course-level perceived control over course performance at Time 2. Student-level perceived control over course performance at Time 2 mediated the relationship between self-efficacy at Time 1 and course-level perseverance, course-specific stress, and course enjoyment at Time 2. For global perceived stress and life satisfaction measured at Time 2, both locus of control and self-efficacy at Time 1 had only a direct effect on global perceived stress at Time 2, but only self-efficacy at Time 1 predicted life satisfaction at Time 2. Both locus of control and self-efficacy uniquely contribute to students' academic experiences. Student-level perceived control plays an important mediating role between locus of control and self-efficacy at Time 1, and course-level perseverance, course-specific stress, and course enjoyment at Time 2.

  19. Parent Mediation Empowers Sibling Conflict Resolution

    Science.gov (United States)

    Ross, Hildy S.; Lazinski, Marysia J.

    2014-01-01

    Research Findings: For the current study, formal mediation procedures were adapted for families and parents were trained and asked to mediate their children's disputes; control group parents intervened as they normally would. Conflict negotiations with parents and their children (ages 3½-11 years) occurring 3 and 7 weeks following training, and…

  20. Siblings' mediated learning strategies in families with and without children with intellectual disabilities.

    Science.gov (United States)

    Tzuriel, David; Hanuka-Levy, Dikla

    2014-11-01

    Dyads of siblings in which the younger sibling had an intellectual disability (ID, n  =  25) were videotaped interacting. The ID group was compared with typically developing sibling dyads matched on mental age (n  =  25) and chronological age (n  =  25). We observed the mediation strategies, activation, and antimediation behaviors of older siblings and younger siblings' responsiveness to mediation. Mediation strategies were analyzed by the Observation of Mediation Interaction scale. The ID group scored highest on mediation strategies and lowest on activation and antimediation behaviors. Younger siblings' responsiveness to mediation was highest among the ID group. Mediation for Intentionality and Reciprocity and Meaning were positively associated with the verbal responsiveness of the younger siblings. Activation and antimediation behaviors were negatively associated with the verbal responsiveness.