Three-dimensional repositioning accuracy of semiadjustable articulator cast mounting systems.

Science.gov (United States)

Tan, Ming Yi; Ung, Justina Youlin; Low, Ada Hui Yin; Tan, En En; Tan, Keson Beng Choon

2014-10-01

In spite of its importance in prosthesis precision and quality, the 3-dimensional repositioning accuracy of cast mounting systems has not been reported in detail. The purpose of this study was to quantify the 3-dimensional repositioning accuracy of 6 selected cast mounting systems. Five magnetic mounting systems were compared with a conventional screw-on system. Six systems on 3 semiadjustable articulators were evaluated: Denar Mark II with conventional screw-on mounting plates (DENSCR) and magnetic mounting system with converter plates (DENCON); Denar Mark 330 with in-built magnetic mounting system (DENMAG) and disposable mounting plates; and Artex CP with blue (ARTBLU), white (ARTWHI), and black (ARTBLA) magnetic mounting plates. Test casts with 3 high-precision ceramic ball bearings at the mandibular central incisor (Point I) and the right and left second molar (Point R; Point L) positions were mounted on 5 mounting plates (n=5) for all 6 systems. Each cast was repositioned 10 times by 4 operators in random order. Nine linear (Ix, Iy, Iz; Rx, Ry, Rz; Lx, Ly, Lz) and 3 angular (anteroposterior, mediolateral, twisting) displacements were measured with a coordinate measuring machine. The mean standard deviations of the linear and angular displacements defined repositioning accuracy. Anteroposterior linear repositioning accuracy ranged from 23.8 ±3.7 μm (DENCON) to 4.9 ±3.2 μm (DENSCR). Mediolateral linear repositioning accuracy ranged from 46.0 ±8.0 μm (DENCON) to 3.7 ±1.5 μm (ARTBLU), and vertical linear repositioning accuracy ranged from 7.2 ±9.6 μm (DENMAG) to 1.5 ±0.9 μm (ARTBLU). Anteroposterior angular repositioning accuracy ranged from 0.0084 ±0.0080 degrees (DENCON) to 0.0020 ±0.0006 degrees (ARTBLU), and mediolateral angular repositioning accuracy ranged from 0.0120 ±0.0111 degrees (ARTWHI) to 0.0027 ±0.0008 degrees (ARTBLU). Twisting angular repositioning accuracy ranged from 0.0419 ±0.0176 degrees (DENCON) to 0.0042 ±0.0038 degrees

An economic analysis of repositioning for the prevention of pressure ulcers.

Science.gov (United States)

Moore, Zena; Cowman, Seamus; Posnett, John

2013-08-01

To compare pressure ulcer incidence and costs associated with repositioning older individuals in long-term care using two different repositioning regimes. Repositioning has not always been integrated into pressure ulcer preventative methods, with arguments that it is an expensive procedure in terms of personnel and time. Participants were randomly allocated to the experimental group (n = 99; repositioned every 3 hours, using the 30° tilt) and the control group (n = 114 standard care, repositioned every 6 hours, using the 90° lateral rotation). The analysis explored the incidence of pressure ulcer development and the cost difference between the two repositioning schedules, over a 4-week period. The mean daily nurse time for repositioning was 18·5 minutes (experimental) and 24·5 minutes (control). Nurse time cost per patient over the study period was €206·6 (experimental) and €253·1 (control), 96·6% of participants (experimental) remained free of pressure ulcers, compared with 88·1% (control). The cost per patient free of ulcer was €213·9 (experimental) and €287·3 (control). Projected annual costs were estimated for the 588 (53·5%) residents in the 12 study sites requiring repositioning. The cost would be €1·59 m (experimental) and €2·10 m (control), a cost difference of €510,000. This represents a difference of 58·8 hours of nurse time, equivalent to approximately 12 full time nurses across the 12 sites. Repositioning every 3 hours, using 30° tilt, has been shown to be more effective in less costly in terms of nurse time compared with standard care. Repositioning individuals at risk of pressure ulcer development makes both economic and clinical sense, thereby supporting the EPUAP/NPUAP 2009 guidelines. © 2013 John Wiley & Sons Ltd.

Digital Speckle Photography of Subpixel Displacements of Speckle Structures Based on Analysis of Their Spatial Spectra

Science.gov (United States)

Maksimova, L. A.; Ryabukho, P. V.; Mysina, N. Yu.; Lyakin, D. V.; Ryabukho, V. P.

2018-04-01

We have investigated the capabilities of the method of digital speckle interferometry for determining subpixel displacements of a speckle structure formed by a displaceable or deformable object with a scattering surface. An analysis of spatial spectra of speckle structures makes it possible to perform measurements with a subpixel accuracy and to extend the lower boundary of the range of measurements of displacements of speckle structures to the range of subpixel values. The method is realized on the basis of digital recording of the images of undisplaced and displaced speckle structures, their spatial frequency analysis using numerically specified constant phase shifts, and correlation analysis of spatial spectra of speckle structures. Transformation into the frequency range makes it possible to obtain quantities to be measured with a subpixel accuracy from the shift of the interference-pattern minimum in the diffraction halo by introducing an additional phase shift into the complex spatial spectrum of the speckle structure or from the slope of the linear plot of the function of accumulated phase difference in the field of the complex spatial spectrum of the displaced speckle structure. The capabilities of the method have been investigated in natural experiment.

Radial lens distortion correction with sub-pixel accuracy for X-ray micro-tomography.

Science.gov (United States)

Vo, Nghia T; Atwood, Robert C; Drakopoulos, Michael

2015-12-14

Distortion correction or camera calibration for an imaging system which is highly configurable and requires frequent disassembly for maintenance or replacement of parts needs a speedy method for recalibration. Here we present direct techniques for calculating distortion parameters of a non-linear model based on the correct determination of the center of distortion. These techniques are fast, very easy to implement, and accurate at sub-pixel level. The implementation at the X-ray tomography system of the I12 beamline, Diamond Light Source, which strictly requires sub-pixel accuracy, shows excellent performance in the calibration image and in the reconstructed images.

Percutaneous transfemoral repositioning of malpositioned central venous catheters.

Science.gov (United States)

Hartnell, G G; Roizental, M

1995-04-01

Central venous catheters inserted by blind surgical placement may not advance into a satisfactory position and may require repositioning. Malpositioning via surgical insertion is common in patients in whom central venous catheters have previously been placed, as these patients are more likely to have central venous thrombosis and distortion of central venous anatomy. This is less of a problem when catheter placement is guided by imaging; however, even when insertion is satisfactory, central venous catheters may become displaced spontaneously after insertion (Fig. 1). Repositioning can be effected by direct manipulation using guidewires or tip-deflecting wires [1, 2], by manipulation via a transfemoral venous approach [3-5], and by injection of contrast material or saline [6]. Limitations of the direct approach include (1) the number and type of maneuvers that can be performed to effect repositioning when anatomy is distorted, (2) difficulty in accessing the catheter, and (3) the risk of introducing infection. Moreover, these patients are often immunosuppressed, and there is a risk of introducing infection by exposing and directly manipulating the venous catheter. Vigorous injection of contrast material or saline may be unsuccessful for the same reasons: It seldom exerts sufficient force to reposition large-caliber central venous catheters and may cause vessel damage or rupture if injection is made into a small or thrombosed vessel. We illustrate several alternative methods for catheter repositioning via a transfemoral venous approach.

2D Sub-Pixel Disparity Measurement Using QPEC / Medicis

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M. Cournet

2016-06-01

Full Text Available In the frame of its earth observation missions, CNES created a library called QPEC, and one of its launcher called Medicis. QPEC / Medicis is a sub-pixel two-dimensional stereo matching algorithm that works on an image pair. This tool is a block matching algorithm, which means that it is based on a local method. Moreover it does not regularize the results found. It proposes several matching costs, such as the Zero mean Normalised Cross-Correlation or statistical measures (the Mutual Information being one of them, and different match validation flags. QPEC / Medicis is able to compute a two-dimensional dense disparity map with a subpixel precision. Hence, it is more versatile than disparity estimation methods found in computer vision literature, which often assume an epipolar geometry. CNES uses Medicis, among other applications, during the in-orbit image quality commissioning of earth observation satellites. For instance the Pléiades-HR 1A & 1B and the Sentinel-2 geometric calibrations are based on this block matching algorithm. Over the years, it has become a common tool in ground segments for in-flight monitoring purposes. For these two kinds of applications, the two-dimensional search and the local sub-pixel measure without regularization can be essential. This tool is also used to generate automatic digital elevation models, for which it was not initially dedicated. This paper deals with the QPEC / Medicis algorithm. It also presents some of its CNES applications (in-orbit commissioning, in flight monitoring or digital elevation model generation. Medicis software is distributed outside the CNES as well. This paper finally describes some of these external applications using Medicis, such as ground displacement measurement, or intra-oral scanner in the dental domain.

The Liner Shipping Fleet Repositioning Problem with Cargo Flows

DEFF Research Database (Denmark)

Tierney, Kevin; Jensen, Rune Møller

2012-01-01

We solve an important problem for the liner shipping industry called the Liner Shipping Fleet Repositioning Problem (LSFRP). The LSFRP poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between services in a liner shipping network. Shippers wish...

Investigating drug repositioning opportunities in FDA drug labels through topic modeling.

Science.gov (United States)

Bisgin, Halil; Liu, Zhichao; Kelly, Reagan; Fang, Hong; Xu, Xiaowei; Tong, Weida

2012-01-01

addition, we identified two therapeutic groups of drugs (Musculo-skeletal system and Anti-infective for systemic use) where over 80% of the drugs have a potential replacement with high significance. Topic modeling can be a powerful tool for the identification of repositioning opportunities by examining the adverse event terms in FDA approved drug labels. The proposed framework not only suggests drugs that can be repurposed, but also provides insight into the safety of repositioned drugs.

Correction of sub-pixel topographical effects on land surface albedo retrieved from geostationary satellite (FengYun-2D) observations

International Nuclear Information System (INIS)

Roupioz, L; Nerry, F; Jia, L; Menenti, M

2014-01-01

The Qinghai-Tibetan Plateau is characterised by a very strong relief which affects albedo retrieval from satellite data. The objective of this study is to highlight the effects of sub-pixel topography and to account for those effects when retrieving land surface albedo from geostationary satellite FengYun-2D (FY-2D) data with 1.25km spatial resolution using the high spatial resolution (30 m) data of the Digital Elevation Model (DEM) from ASTER. The methodology integrates the effects of sub-pixel topography on the estimation of the total irradiance received at the surface, allowing the computation of the topographically corrected surface reflectance. Furthermore, surface albedo is estimated by applying the parametric BRDF (Bidirectional Reflectance Distribution Function) model called RPV (Rahman-Pinty-Verstraete) to the terrain corrected surface reflectance. The results, evaluated against ground measurements collected over several experimental sites on the Qinghai-Tibetan Plateau, document the advantage of integrating the sub-pixel topography effects in the land surface reflectance at 1km resolution to estimate the land surface albedo. The results obtained after using sub-pixel topographic correction are compared with the ones obtained after using pixel level topographic correction. The preliminary results imply that, in highly rugged terrain, the sub-pixel topography correction method gives more accurate results. The pixel level correction tends to overestimate surface albedo

Drug repositioning: playing dirty to kill pain.

Science.gov (United States)

Bastos, Leandro Francisco Silva; Coelho, Márcio Matos

2014-01-01

The number of approved new molecular entity drugs has been decreasing as the pharmaceutical company investment in research and development is increasing. As we face this painful crisis, called an innovation gap, there is increasing awareness that development of new uses of existing drugs may be a powerful tool to help overcome this obstacle because it takes too long, costs too much and can be risky to release drugs developed de novo. Consequently, drug repositioning is emerging in different therapeutic areas, including the pain research area. Worldwide, pain is the main reason for seeking healthcare, and pain relief represents an unmet global clinical need. Therefore, development of analgesics with better efficacy, safety and cost effectiveness is of paramount importance. Despite the remarkable advancement in research on cellular and molecular mechanisms underlying pain pathophysiology over the past three decades, target-based therapeutic opportunities have not been pursued to the same extent. Phenotypic screening remains a more powerful tool for drug development than target-based screening so far. It sounds somewhat heretical, but some multi-action drugs, rather than very selective ones, have been developed intentionally. In the present review, we first critically discuss the utility of drug repositioning for analgesic drug development and then show examples of 'old' drugs that have been successfully repositioned or that are under investigation for their analgesic actions. We conclude that drug repositioning should be more strongly encouraged to help build a bridge between basic research and pain relief worldwide.

Large-scale computational drug repositioning to find treatments for rare diseases.

Science.gov (United States)

Govindaraj, Rajiv Gandhi; Naderi, Misagh; Singha, Manali; Lemoine, Jeffrey; Brylinski, Michal

2018-01-01

Rare, or orphan, diseases are conditions afflicting a small subset of people in a population. Although these disorders collectively pose significant health care problems, drug companies require government incentives to develop drugs for rare diseases due to extremely limited individual markets. Computer-aided drug repositioning, i.e., finding new indications for existing drugs, is a cheaper and faster alternative to traditional drug discovery offering a promising venue for orphan drug research. Structure-based matching of drug-binding pockets is among the most promising computational techniques to inform drug repositioning. In order to find new targets for known drugs ultimately leading to drug repositioning, we recently developed e MatchSite, a new computer program to compare drug-binding sites. In this study, e MatchSite is combined with virtual screening to systematically explore opportunities to reposition known drugs to proteins associated with rare diseases. The effectiveness of this integrated approach is demonstrated for a kinase inhibitor, which is a confirmed candidate for repositioning to synapsin Ia. The resulting dataset comprises 31,142 putative drug-target complexes linked to 980 orphan diseases. The modeling accuracy is evaluated against the structural data recently released for tyrosine-protein kinase HCK. To illustrate how potential therapeutics for rare diseases can be identified, we discuss a possibility to repurpose a steroidal aromatase inhibitor to treat Niemann-Pick disease type C. Overall, the exhaustive exploration of the drug repositioning space exposes new opportunities to combat orphan diseases with existing drugs. DrugBank/Orphanet repositioning data are freely available to research community at https://osf.io/qdjup/.

A stepwise regression tree for nonlinear approximation: applications to estimating subpixel land cover

Science.gov (United States)

Huang, C.; Townshend, J.R.G.

2003-01-01

A stepwise regression tree (SRT) algorithm was developed for approximating complex nonlinear relationships. Based on the regression tree of Breiman et al . (BRT) and a stepwise linear regression (SLR) method, this algorithm represents an improvement over SLR in that it can approximate nonlinear relationships and over BRT in that it gives more realistic predictions. The applicability of this method to estimating subpixel forest was demonstrated using three test data sets, on all of which it gave more accurate predictions than SLR and BRT. SRT also generated more compact trees and performed better than or at least as well as BRT at all 10 equal forest proportion interval ranging from 0 to 100%. This method is appealing to estimating subpixel land cover over large areas.

Solving the Liner Shipping Fleet Repositioning Problem with Cargo Flows

DEFF Research Database (Denmark)

Tierney, Kevin; Askelsdottir, Björg; Jensen, Rune Møller

2015-01-01

We solve a central problem in the liner shipping industry called the liner shipping fleet repositioning problem (LSFRP). The LSFRP poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between routes in a liner shipping network. Liner carriers wish...

47 CFR 76.1601 - Deletion or repositioning of broadcast signals.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Deletion or repositioning of broadcast signals... RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1601 Deletion or... to § 76.1601: No deletion or repositioning of a local commercial television station shall occur...

On the importance of retaining stresses and strains in repositioning computational biomechanical models of the cervical spine.

Science.gov (United States)

Boakye-Yiadom, Solomon; Cronin, Duane S

2018-01-01

Human body models are created in a specific posture and often repositioned and analyzed without retaining stresses that result from repositioning. For example, repositioning a human neck model within the physiological range of motion to a head-turned posture prior to an impact results in initial stresses within the tissues distracted from their neutral position. The aim of this study was to investigate the effect of repositioning on the subsequent kinetics, kinematics, and failure modes, of a lower cervical spine motion segment, to support future research at the full neck level. Repositioning was investigated for 3 modes (tension, flexion, and extension) and 3 load cases. The model was repositioned and loaded to failure in one continuous load history (case 1), or repositioned then restarted with retained stresses and loaded to failure (case 2). In case 3, the model was repositioned and then restarted in a stress-free state, representing current repositioning methods. Not retaining the repositioning stresses and strains resulted in different kinetics, kinematics, or failure modes, depending on the mode of loading. For the motion segment model, the differences were associated with the intervertebral disc fiber reorientation and load distribution, because the disc underwent the largest deformation during repositioning. This study demonstrated that repositioning led to altered response and tissue failure, which is critical for computational models intended to predict injury at the tissue level. It is recommended that stresses and strains be included and retained for subsequent analysis when repositioning a human computational neck model. Copyright © 2017 John Wiley & Sons, Ltd.

Subpixel level mapping of remotely sensed image using colorimetry

Directory of Open Access Journals (Sweden)

M. Suresh

2018-04-01

Full Text Available The problem of extracting proportion of classes present within a pixel has been a challenge for researchers for which already numerous methodologies have been developed but still saturation is far ahead, since still the methods accounting these mixed classes are not perfect and they would never be perfect until one can talk about one to one correspondence for each pixel and ground data, which is practically impossible. In this paper a step towards generation of new method for finding out mixed class proportions in a pixel on the basis of the mixing property of colors as per colorimetry. The methodology involves locating the class color of a mixed pixel on chromaticity diagram and then using contextual information mainly the location of neighboring pixels on chromaticity diagram to estimate the proportion of classes in the mixed pixel.Also the resampling method would be more accurate when accounting for sharp and exact boundaries. With the usage of contextual information can generate the resampled image containing only the colors which really exist. The process is simply accounting the fraction and then the number of pixels by multiplying the fraction by total number of pixels into which one pixel is splitted to get number of pixels of each color based on contextual information. Keywords: Subpixel classification, Remote sensing imagery, Colorimetric color space, Sampling and subpixel mapping

Coordenadores de comunidades de repositórios institucionais: o caso do repositóriumCoordinators of institutional repositories communities: the repositórium case

Directory of Open Access Journals (Sweden)

Flávia Garcia Rosa

2010-01-01

Full Text Available O Movimento do Acesso Livre – Open Access Movement (OAM – foi estimulado por dois eventos importantes: a evolução das TIC, processo facilitador da disseminação e acessibilidade à informação, e os elevados custos das publicações científicas impressas, face a contextos de maiores constrangimentos financeiros da instituições de ensino superior e de investigação. Os Repositórios Institucionais (RI são um dos elementos fundamentais do OAM e encontram-se em processo de expansão. Este texto reporta-se a um estudo focado nos coordenadores de comunidades do repositório institucional da Universidade do Minho tendo por objectivos a identificação do perfil dos coordenadores e a identificação de práticas de estímulo ao depósito ao nível das diferentes comunidades. A metodologia de investigação adoptada consistiu num levantamento (survey através de um questionário online. Os dados recolhidos apontam para o reconhecimento, por parte dos coordenadores, das vantagens associadas ao depósito em RI, mas identificam também casos de desconhecimento do OAM e de baixo nível de auto-arquivamento por parte de alguns coordenadores de comunidades. São identificadas como principais iniciativas ao nível das políticas de estímulo ao depósito, por parte das várias comunidades, a “obrigatoriedade do depósito” e práticas de “apoio mediado”. A análise dos dados recolhidos conduziu-nos a um conjunto de reflexões que entendemos poderem ser aplicadas ao caso do RepositóriUM, mas também constituir uma orientação para outros RI em desenvolvimento.

oVEMP as an objective indicator of successful repositioning maneuver.

Science.gov (United States)

Asal, Samir; Sobhy, Osama; Balbaa, Amany

Benign paroxysmal positioning vertigo (BPPV) is the most common peripheral vestibular disorder. Canalolithiasis in the posterior semi-circular canal is the most common underlying pathology that can be treated effectively by repositioning maneuvers. Our hypothesis suggested that successful maneuvers can lead to repositioning of dislodged otoconia to the utricle. Air conducted oVEMP, which is thought to originate from the contra-lateral utricular organ was measured in twenty patients with unilateral BPPV and we compared n1-p1 peak to peak amplitude of the affected ears in 3 separate intervals: on pre-treatment when typical nystagmus was confirmed, immediately after, and 1 week after repositioning maneuvers to assess change, if any, in amplitude. This study showed significant increase of oVEMP amplitude in the affected ears after successful repositioning maneuver that was more significant after 1 week. oVEMP can be used as a reliable objective test for ensuring a successful maneuver rather than subjective dependence on the patient's symptoms, which may be misleading due to a remission. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. All rights reserved.

Improving sub-pixel imperviousness change prediction by ensembling heterogeneous non-linear regression models

Science.gov (United States)

Drzewiecki, Wojciech

2016-12-01

In this work nine non-linear regression models were compared for sub-pixel impervious surface area mapping from Landsat images. The comparison was done in three study areas both for accuracy of imperviousness coverage evaluation in individual points in time and accuracy of imperviousness change assessment. The performance of individual machine learning algorithms (Cubist, Random Forest, stochastic gradient boosting of regression trees, k-nearest neighbors regression, random k-nearest neighbors regression, Multivariate Adaptive Regression Splines, averaged neural networks, and support vector machines with polynomial and radial kernels) was also compared with the performance of heterogeneous model ensembles constructed from the best models trained using particular techniques. The results proved that in case of sub-pixel evaluation the most accurate prediction of change may not necessarily be based on the most accurate individual assessments. When single methods are considered, based on obtained results Cubist algorithm may be advised for Landsat based mapping of imperviousness for single dates. However, Random Forest may be endorsed when the most reliable evaluation of imperviousness change is the primary goal. It gave lower accuracies for individual assessments, but better prediction of change due to more correlated errors of individual predictions. Heterogeneous model ensembles performed for individual time points assessments at least as well as the best individual models. In case of imperviousness change assessment the ensembles always outperformed single model approaches. It means that it is possible to improve the accuracy of sub-pixel imperviousness change assessment using ensembles of heterogeneous non-linear regression models.

Biomechanical Evaluation of a Bed Feature to Assist in Turning and Laterally Repositioning Patients.

Science.gov (United States)

Wiggermann, Neal

2016-08-01

This study investigated the effects of hospital bed features on the biomechanical stresses experienced by nurses when turning and laterally repositioning patients. Turn Assist, a common feature in ICU beds that helps to rotate patients, and side rail orientation were evaluated. Manual patient handling is a risk factor for musculoskeletal injury, and turning patients is one of the most common patient handling activities. No known studies have evaluated bed attributes such as the Turn Assist feature and side rail orientation that may affect the stresses experienced by the nurse. Nine female nurses laterally repositioned and turned a 63-kg and 123-kg subject on an ICU bed while motion capture, ground reaction forces, and hand force data were recorded. Loading of the spine and shoulder was modeled using 3D Static Strength Prediction Program (3DSSPP). Spine compression and shear forces did not exceed recommended limits when turning or laterally repositioning. However, the mean pull forces required to manually laterally reposition even the 63-kg subject was 340 Newtons, more than 50% greater than limits established in psychophysical testing. Turn Assist considerably reduced spine loading and pull forces for both turning and laterally repositioning. Lowering side rails reduced spinal compression by 11% when turning patients. Laterally repositioning patients as part of turning may pose an injury risk to caregivers. Turn Assist reduces physical loading on nurses when turning and repositioning patients. Caregivers should consider using Turn Assist and other aids such as mechanical lifts or sliding sheets especially when turning patients requires lateral repositioning. © 2015, Human Factors and Ergonomics Society.

Drug repositioning for enzyme modulator based on human metabolite-likeness.

Science.gov (United States)

Lee, Yoon Hyeok; Choi, Hojae; Park, Seongyong; Lee, Boah; Yi, Gwan-Su

2017-05-31

Recently, the metabolite-likeness of the drug space has emerged and has opened a new possibility for exploring human metabolite-like candidates in drug discovery. However, the applicability of metabolite-likeness in drug discovery has been largely unexplored. Moreover, there are no reports on its applications for the repositioning of drugs to possible enzyme modulators, although enzyme-drug relations could be directly inferred from the similarity relationships between enzyme's metabolites and drugs. We constructed a drug-metabolite structural similarity matrix, which contains 1,861 FDA-approved drugs and 1,110 human intermediary metabolites scored with the Tanimoto similarity. To verify the metabolite-likeness measure for drug repositioning, we analyzed 17 known antimetabolite drugs that resemble the innate metabolites of their eleven target enzymes as the gold standard positives. Highly scored drugs were selected as possible modulators of enzymes for their corresponding metabolites. Then, we assessed the performance of metabolite-likeness with a receiver operating characteristic analysis and compared it with other drug-target prediction methods. We set the similarity threshold for drug repositioning candidates of new enzyme modulators based on maximization of the Youden's index. We also carried out literature surveys for supporting the drug repositioning results based on the metabolite-likeness. In this paper, we applied metabolite-likeness to repurpose FDA-approved drugs to disease-associated enzyme modulators that resemble human innate metabolites. All antimetabolite drugs were mapped with their known 11 target enzymes with statistically significant similarity values to the corresponding metabolites. The comparison with other drug-target prediction methods showed the higher performance of metabolite-likeness for predicting enzyme modulators. After that, the drugs scored higher than similarity score of 0.654 were selected as possible modulators of enzymes for

Drug Repositioning for Effective Prostate Cancer Treatment.

Science.gov (United States)

Turanli, Beste; Grøtli, Morten; Boren, Jan; Nielsen, Jens; Uhlen, Mathias; Arga, Kazim Y; Mardinoglu, Adil

2018-01-01

Drug repositioning has gained attention from both academia and pharmaceutical companies as an auxiliary process to conventional drug discovery. Chemotherapeutic agents have notorious adverse effects that drastically reduce the life quality of cancer patients so drug repositioning is a promising strategy to identify non-cancer drugs which have anti-cancer activity as well as tolerable adverse effects for human health. There are various strategies for discovery and validation of repurposed drugs. In this review, 25 repurposed drug candidates are presented as result of different strategies, 15 of which are already under clinical investigation for treatment of prostate cancer (PCa). To date, zoledronic acid is the only repurposed, clinically used, and approved non-cancer drug for PCa. Anti-cancer activities of existing drugs presented in this review cover diverse and also known mechanisms such as inhibition of mTOR and VEGFR2 signaling, inhibition of PI3K/Akt signaling, COX and selective COX-2 inhibition, NF-κB inhibition, Wnt/β-Catenin pathway inhibition, DNMT1 inhibition, and GSK-3β inhibition. In addition to monotherapy option, combination therapy with current anti-cancer drugs may also increase drug efficacy and reduce adverse effects. Thus, drug repositioning may become a key approach for drug discovery in terms of time- and cost-efficiency comparing to conventional drug discovery and development process.

Management of excessive gingival display: Lip repositioning technique

Directory of Open Access Journals (Sweden)

Upasana Sthapak

2015-01-01

Full Text Available The lips form the frame of a smile and define the esthetic zone. Excessive gingival display during smile is often referred to as "gummy smile". A successful management of excessive gingival display with lip repositioning procedure has shown excellent results. The procedure involves removing a strip of partial thickness mucosa from maxillary vestibule, then suturing it back to the lip mucosa at the level of mucogingival junction. This technique results in restricted muscle pull and a narrow vestibule, thereby reducing the gingival display. In this case gummy smile was treated by modification of Rubinstein and Kostianovsky′s surgical lip repositioning technique which resulted in a harmonious smile.

A physarum-inspired prize-collecting steiner tree approach to identify subnetworks for drug repositioning.

Science.gov (United States)

Sun, Yahui; Hameed, Pathima Nusrath; Verspoor, Karin; Halgamuge, Saman

2016-12-05

Drug repositioning can reduce the time, costs and risks of drug development by identifying new therapeutic effects for known drugs. It is challenging to reposition drugs as pharmacological data is large and complex. Subnetwork identification has already been used to simplify the visualization and interpretation of biological data, but it has not been applied to drug repositioning so far. In this paper, we fill this gap by proposing a new Physarum-inspired Prize-Collecting Steiner Tree algorithm to identify subnetworks for drug repositioning. Drug Similarity Networks (DSN) are generated using the chemical, therapeutic, protein, and phenotype features of drugs. In DSNs, vertex prizes and edge costs represent the similarities and dissimilarities between drugs respectively, and terminals represent drugs in the cardiovascular class, as defined in the Anatomical Therapeutic Chemical classification system. A new Physarum-inspired Prize-Collecting Steiner Tree algorithm is proposed in this paper to identify subnetworks. We apply both the proposed algorithm and the widely-used GW algorithm to identify subnetworks in our 18 generated DSNs. In these DSNs, our proposed algorithm identifies subnetworks with an average Rand Index of 81.1%, while the GW algorithm can only identify subnetworks with an average Rand Index of 64.1%. We select 9 subnetworks with high Rand Index to find drug repositioning opportunities. 10 frequently occurring drugs in these subnetworks are identified as candidates to be repositioned for cardiovascular diseases. We find evidence to support previous discoveries that nitroglycerin, theophylline and acarbose may be able to be repositioned for cardiovascular diseases. Moreover, we identify seven previously unknown drug candidates that also may interact with the biological cardiovascular system. These discoveries show our proposed Prize-Collecting Steiner Tree approach as a promising strategy for drug repositioning.

Rapid and Promising Technique to Treat Gummy Smile-Lip Repositioning

International Nuclear Information System (INIS)

Khan, M. N.; Akbar, Z.; Shah, I.

2017-01-01

Beautiful smile is a booster to person's confidence. Gummy smile is a term used for excessive gingival display (EGD). Its etiology is multifactorial. Bone vertical maxillary excess (VME) is one of the cause of EGD. In this case series, lip repositioning was performed to treat mild to moderate degree of gingival display ( 2 to 8 mm) due to VME. Lip repositioning is simple, promising, meticulous and comparatively cheap alternative technique for treating gummy smile. (author)

Drug repositioning: Re-investigating existing drugs for new therapeutic indications

Directory of Open Access Journals (Sweden)

B M Padhy

2011-01-01

Full Text Available Drug discovery and development is an expensive, time-consuming, and risky enterprise. In order to accelerate the drug development process with reduced risk of failure and relatively lower costs, pharmaceutical companies have adopted drug repositioning as an alternative. This strategy involves exploration of drugs that have already been approved for treatment of other diseases and/or whose targets have already been discovered. Various techniques including data mining, bioinformatics, and usage of novel screening platforms have been used for identification and screening of potential repositioning candidates. However, challenges in clinical trials and intellectual property issues may be encountered during the repositioning process. Nevertheless, such initiatives not only add value to the portfolio of pharmaceutical companies but also provide an opportunity for academia and government laboratories to develop new and innovative uses of existing drugs for infectious and neglected diseases, especially in emerging countries like India.

Drug repositioning: re-investigating existing drugs for new therapeutic indications.

Science.gov (United States)

Padhy, B M; Gupta, Y K

2011-01-01

Drug discovery and development is an expensive, time-consuming, and risky enterprise. In order to accelerate the drug development process with reduced risk of failure and relatively lower costs, pharmaceutical companies have adopted drug repositioning as an alternative. This strategy involves exploration of drugs that have already been approved for treatment of other diseases and/or whose targets have already been discovered. Various techniques including data mining, bioinformatics, and usage of novel screening platforms have been used for identification and screening of potential repositioning candidates. However, challenges in clinical trials and intellectual property issues may be encountered during the repositioning process. Nevertheless, such initiatives not only add value to the portfolio of pharmaceutical companies but also provide an opportunity for academia and government laboratories to develop new and innovative uses of existing drugs for infectious and neglected diseases, especially in emerging countries like India.

Cases requiring increased number of repositioning maneuvers in benign paroxysmal positional vertigo

Directory of Open Access Journals (Sweden)

Mukadder Korkmaz

Full Text Available ABSTRACT INTRODUCTION: Benign paroxysmal positional vertigo (BPPV is a clinical syndrome that is proposed to be caused by dislocated utricular debris into semicircular canals. Although the majority of patients are treated by one or two repositioning maneuvers, some of the patients need repeated maneuvers for relief. OBJECTIVE: The goal of this study was to investigate the factors associated with patients with benign paroxysmal positional vertigo who required multiple repositioning procedures for treatment. METHODS: Data were obtained from the clinical records of 153 patients diagnosed with benign paroxysmal positional vertigo. Patients were treated by repositioning maneuvers. Demographic data and the factors including age, sex, canal type, duration of symptoms, comorbidities and number of repositioning maneuvers for relief were documented for statistical analysis. RESULTS: Age, sex, canal type and the duration of symptoms had no impact on the number of maneuvers. The most common comorbidity was spine problems. Hypertension was the only comorbidity that significantly associated with increased number of maneuvers. CONCLUSION: The presence of hypertension is a risk factor for repeated maneuvers in benign paroxysmal positional vertigo treatment. Physicians should be aware of the increased probability of repeated repositioning maneuvers in these group of patients. The role of comorbidities and vascular factors need to be further clarified in the course of benign paroxysmal positional vertigo.

Cases requiring increased number of repositioning maneuvers in benign paroxysmal positional vertigo.

Science.gov (United States)

Korkmaz, Mukadder; Korkmaz, Hakan

2016-01-01

Benign paroxysmal positional vertigo (BPPV) is a clinical syndrome that is proposed to be caused by dislocated utricular debris into semicircular canals. Although the majority of patients are treated by one or two repositioning maneuvers, some of the patients need repeated maneuvers for relief. The goal of this study was to investigate the factors associated with patients with benign paroxysmal positional vertigo who required multiple repositioning procedures for treatment. Data were obtained from the clinical records of 153 patients diagnosed with benign paroxysmal positional vertigo. Patients were treated by repositioning maneuvers. Demographic data and the factors including age, sex, canal type, duration of symptoms, comorbidities and number of repositioning maneuvers for relief were documented for statistical analysis. Age, sex, canal type and the duration of symptoms had no impact on the number of maneuvers. The most common comorbidity was spine problems. Hypertension was the only comorbidity that significantly associated with increased number of maneuvers. The presence of hypertension is a risk factor for repeated maneuvers in benign paroxysmal positional vertigo treatment. Physicians should be aware of the increased probability of repeated repositioning maneuvers in these group of patients. The role of comorbidities and vascular factors need to be further clarified in the course of benign paroxysmal positional vertigo. Copyright © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

Repositórios institucionais de acesso livre no Brasil: estudo Delfos

Directory of Open Access Journals (Sweden)

Ernani Rufino dos Santos Junior

2015-06-01

Full Text Available A filosofia do acesso livre ao conhecimento científico surgiu da dificuldade das bibliotecas universitárias de todo mundo em manter atualizadas as assinaturas das coleções de periódicos científicos. Os repositórios institucionais são uma das ferramentas que se mostram como alternativa para a comunicação da Ciência livre de barreiras de acesso. A pesquisa tem por objetivo verificar quais são as perspectivas futuras das atuais políticas de implementação de repositórios institucionais de acesso livre no Brasil na opinião de especialistas na área, tendo como base a análise do estado da arte das implementações de Repositórios Institucionais no Brasil. Neste trabalho, a pesquisa é dividida em três etapas: a primeira consiste na coleta de dados descritivos dos repositórios institucionais da Universidade de Brasília (RIUnB e do Superior Tribunal de Justiça (BDJur-STJ; já na segunda etapa de pesquisa, procede-se à consulta aos especialistas indagando-os acerca da situação atual das implementações de repositórios institucionais no Brasil; e, por fim, na terceira etapa de pesquisa consultamos estes mesmos especialistas sobre os desdobramentos futuros destas políticas no País. Utilizamos da técnica Delfos de pesquisa, onde os especialistas são consultados através de questionários constituídos de perguntas abertas, possibilitando assim chegar a um consenso das opiniões no final da pesquisa. Como resultado da pesquisa, é elaborado um quadro com a tabulação das respostas dos especialistas consultados revelando o panorama das perspectivas futuras das implementações de repositórios institucionais no Brasil na opinião dos especialistas que fazem parte da nossa amostra de pesquisa.

POSTOPERATIVE URINARY RETENTION AND EARLY REPOSITION OF TENSION-FREE VAGINAL TAPE

Directory of Open Access Journals (Sweden)

Marijan Lužnik

2003-12-01

Full Text Available Background. The purpose of this article is to show a possible method of treatment of postoperative urinary retention after an initial tension-free vaginal tape.Methods. From December 1999 to May 2003 we performed one hundred TVT procedures at our department, among them five women had postoperative urinary retention evaluated with catheterization. Revision and reposition of tension-free vaginal tape were performed if retention of urine was over 100 ml.Results. Urinary retention after an initial tension-free vaginal tape was successfully treated by early reposition of tension-free vaginal tape. This resulted in immediate residualfree voiding and continence, which remained unchanged at 6 week and 3 month follow-up.Conclusions. Postoperative urinary retention may be treated by reposition instead of dissection or elongation of the tension-free vaginal tape.

A robust Hough transform algorithm for determining the radiation centers of circular and rectangular fields with subpixel accuracy

Energy Technology Data Exchange (ETDEWEB)

Du Weiliang; Yang, James [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 94, Houston, TX 77030 (United States)], E-mail: wdu@mdanderson.org

2009-02-07

Uncertainty in localizing the radiation field center is among the major components that contribute to the overall positional error and thus must be minimized. In this study, we developed a Hough transform (HT)-based computer algorithm to localize the radiation center of a circular or rectangular field with subpixel accuracy. We found that the HT method detected the centers of the test circular fields with an absolute error of 0.037 {+-} 0.019 pixels. On a typical electronic portal imager with 0.5 mm image resolution, this mean detection error was translated to 0.02 mm, which was much finer than the image resolution. It is worth noting that the subpixel accuracy described here does not include experimental uncertainties such as linac mechanical instability or room laser inaccuracy. The HT method was more accurate and more robust to image noise and artifacts than the traditional center-of-mass method. Application of the HT method in Winston-Lutz tests was demonstrated to measure the ball-radiation center alignment with subpixel accuracy. Finally, the method was applied to quantitative evaluation of the radiation center wobble during collimator rotation.

Detection of Olea europaea subsp. cuspidata and Juniperus procera in the dry Afromontane forest of northern Ethiopia using subpixel analysis of Landsat imagery

Science.gov (United States)

Hishe, Hadgu; Giday, Kidane; Neka, Mulugeta; Soromessa, Teshome; Van Orshoven, Jos; Muys, Bart

2015-01-01

Comprehensive and less costly forest inventory approaches are required to monitor the spatiotemporal dynamics of key species in forest ecosystems. Subpixel analysis using the earth resources data analysis system imagine subpixel classification procedure was tested to extract Olea europaea subsp. cuspidata and Juniperus procera canopies from Landsat 7 enhanced thematic mapper plus imagery. Control points with various canopy area fractions of the target species were collected to develop signatures for each of the species. With these signatures, the imagine subpixel classification procedure was run for each species independently. The subpixel process enabled the detection of O. europaea subsp. cuspidata and J. procera trees in pure and mixed pixels. Total of 100 pixels each were field verified for both species. An overall accuracy of 85% was achieved for O. europaea subsp. cuspidata and 89% for J. procera. A high overall accuracy level of detecting species at a natural forest was achieved, which encourages using the algorithm for future species monitoring activities. We recommend that the algorithm has to be validated in similar environment to enrich the knowledge on its capability to ensure its wider usage.

Monorail system for percutaneous repositioning of the Greenfield vena caval filter.

Science.gov (United States)

Guthaner, D F; Wyatt, J O; Mehigan, J T; Wright, A M; Breen, J F; Wexler, L

1990-09-01

The authors describe a technique for removing or repositioning a malpositioned Greenfield inferior vena caval filter. A "monorail" system was used, in which a wire was passed from the femoral vein through the apical hole in the filter and out the internal jugular vein; the wire was held taut from above and below and thus facilitated repositioning or removal of the filter. The technique was used successfully in two cases.

Application of adjusted subpixel method (ASM) in HRCT measurements of the bronchi in bronchial asthma patients and healthy individuals.

Science.gov (United States)

Mincewicz, Grzegorz; Rumiński, Jacek; Krzykowski, Grzegorz

2012-02-01

Recently, we described a model system which included corrections of high-resolution computed tomography (HRCT) bronchial measurements based on the adjusted subpixel method (ASM). To verify the clinical application of ASM by comparing bronchial measurements obtained by means of the traditional eye-driven method, subpixel method alone and ASM in a group comprised of bronchial asthma patients and healthy individuals. The study included 30 bronchial asthma patients and the control group comprised of 20 volunteers with no symptoms of asthma. The lowest internal and external diameters of the bronchial cross-sections (ID and ED) and their derivative parameters were determined in HRCT scans using: (1) traditional eye-driven method, (2) subpixel technique, and (3) ASM. In the case of the eye-driven method, lower ID values along with lower bronchial lumen area and its percentage ratio to total bronchial area were basic parameters that differed between asthma patients and healthy controls. In the case of the subpixel method and ASM, both groups were not significantly different in terms of ID. Significant differences were observed in values of ED and total bronchial area with both parameters being significantly higher in asthma patients. Compared to ASM, the eye-driven method overstated the values of ID and ED by about 30% and 10% respectively, while understating bronchial wall thickness by about 18%. Results obtained in this study suggest that the traditional eye-driven method of HRCT-based measurement of bronchial tree components probably overstates the degree of bronchial patency in asthma patients. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Application of adjusted subpixel method (ASM) in HRCT measurements of the bronchi in bronchial asthma patients and healthy individuals

International Nuclear Information System (INIS)

Mincewicz, Grzegorz; Rumiński, Jacek; Krzykowski, Grzegorz

2012-01-01

Background: Recently, we described a model system which included corrections of high-resolution computed tomography (HRCT) bronchial measurements based on the adjusted subpixel method (ASM). Objective: To verify the clinical application of ASM by comparing bronchial measurements obtained by means of the traditional eye-driven method, subpixel method alone and ASM in a group comprised of bronchial asthma patients and healthy individuals. Methods: The study included 30 bronchial asthma patients and the control group comprised of 20 volunteers with no symptoms of asthma. The lowest internal and external diameters of the bronchial cross-sections (ID and ED) and their derivative parameters were determined in HRCT scans using: (1) traditional eye-driven method, (2) subpixel technique, and (3) ASM. Results: In the case of the eye-driven method, lower ID values along with lower bronchial lumen area and its percentage ratio to total bronchial area were basic parameters that differed between asthma patients and healthy controls. In the case of the subpixel method and ASM, both groups were not significantly different in terms of ID. Significant differences were observed in values of ED and total bronchial area with both parameters being significantly higher in asthma patients. Compared to ASM, the eye-driven method overstated the values of ID and ED by about 30% and 10% respectively, while understating bronchial wall thickness by about 18%. Conclusions: Results obtained in this study suggest that the traditional eye-driven method of HRCT-based measurement of bronchial tree components probably overstates the degree of bronchial patency in asthma patients.

Ideas, properties, and standards of fracture repositioning with osteopathy in traditional Mongolian medicine in China.

Science.gov (United States)

Wang, Mei; Wang, Hongxia; Zhao, Namula

2015-02-01

To explore the unique ideas, properties, and standards of fracture repositioning with osteopathy in traditional Mongolian medicine in China. Based on the natural life concept of "integration of universe and man", osteopathy in traditional Mongolian medicine in China uses the modern principles and methods of physiology, psychology, and biomechanics. Against this background, we explored the unique ideas, properties, and stan- dards of fracture repositioning in traditional Mongolian medicine. Fracture treatment with osteopathy in traditional Mongolian medicine in China is based on (a) the ideas of natural, sealed, self and dynamic repositioning of fractures; (b) the properties of structural continuity and functional completeness; (c) the standards of "integration of movement and stillness" and "force to force". The unique ideas, properties, and standards of fracture repositioning with osteopathy in traditional Mongolian medicine in China have resulted in the widespread use of such techniques and represents the future direction of the development of fracture repositioning.

Sensitivity of the normalized difference vegetation index to subpixel canopy cover, soil albedo, and pixel scale

Science.gov (United States)

Jasinski, Michael F.

1990-01-01

An analytical framework is provided for examining the physically based behavior of the normalized difference vegetation index (NDVI) in terms of the variability in bulk subpixel landscape components and with respect to variations in pixel scales, within the context of the stochastic-geometric canopy reflectance model. Analysis focuses on regional scale variability in horizontal plant density and soil background reflectance distribution. Modeling is generalized to different plant geometries and solar angles through the use of the nondimensional solar-geometric similarity parameter. Results demonstrate that, for Poisson-distributed plants and for one deterministic distribution, NDVI increases with increasing subpixel fractional canopy amount, decreasing soil background reflectance, and increasing shadows, at least within the limitations of the geometric reflectance model. The NDVI of a pecan orchard and a juniper landscape is presented and discussed.

Repositioning chairs in benign paroxysmal positional vertigo

DEFF Research Database (Denmark)

West, Niels; Hansen, Søren; Møller, Martin Nue

2016-01-01

The objective was to evaluate the clinical value of repositioning chairs in management of refractory benign paroxysmal positional vertigo (BPPV) and to study how different BPPV subtypes respond to treatment. We performed a retrospective chart review of 150 consecutive cases with refractory vertigo...

Vertical repositioning accuracy of magnetic mounting systems on 4 articulator models.

Science.gov (United States)

Lee, Wonsup; Kwon, Ho-Beom

2018-03-01

Research of the ability of a cast mounted on an articulator on maintaining the identical position of a cast mounted on an articulator after repeated repositioning is lacking, despite the possible effects this may have on the occlusion of a mounted cast. The purpose of this in vitro study was to verify and compare the vertical repositioning accuracy of 4 different, commercially available articulator magnetic mounting plate systems. Four articulators and their associated magnetic mounting plates were selected for the study. These were the Artex AR articulator (Amann Girrbach AG), the Denar Mark II articulator (Whip Mix Corp), the Kavo Protar Evo articulator (Kavo Dental GmbH), and the SAM3 articulator (SAM Präzisionstechnik GmbH). Three new magnetic mounting plates were prepared for each articulator system. The repositioning accuracy of each mounting plate was evaluated by comparing the standard deviation of the vertical distances measured between the mounting plate and a laser displacement sensor. The lower arm of the articulator was secured, and the vertical distance was measured by positioning the laser displacement sensor positioned vertically above the mounting plate. Once the vertical distance was measured, the mounting plate was detached from the articulator and reattached manually to prepare for the next measurement. This procedure was repeated 30 times for each of the 3 magnetic mounting plates. Data were analyzed by ANOVA for 2-stage nested design and the Levene test (α=.05). Significant differences were detected among articulator systems and between magnetic mounting plates of the same type. The standard deviations of the measurements made with the Artex AR articulator, Denar Mark II articulator, Kavo Protar Evo articulator, and SAM3 articulator were 0.0027, 0.0308, 0.0214, and 0.0215 mm, respectively. Thus, the repositioning accuracy could be ranked in the order as follows: Artex AR, Kavo Protar Evo, SAM3, and Denar Mark II. The position of the

Competencies and materials for repositioning cataloguers for ...

African Journals Online (AJOL)

The purpose of this study was to determine the competencies and materials for repositioning cataloguers for information management in an electronic era. The survey method was adopted for the research design using questionnaire for data collection. The population comprised of 44 cataloguers in 12 universities in ...

Spatial positioning of all 24 chromosomes in the lymphocytes of six subjects: evidence of reproducible positioning and spatial repositioning following DNA damage with hydrogen peroxide and ultraviolet B.

Directory of Open Access Journals (Sweden)

Dimitrios Ioannou

Full Text Available The higher-order organization of chromatin is well-established, with chromosomes occupying distinct positions within the interphase nucleus. Chromatin is susceptible to, and constantly assaulted by both endogenous and exogenous threats. However, the effects of DNA damage on the spatial topology of chromosomes are hitherto, poorly understood. This study investigates the organization of all 24 human chromosomes in lymphocytes from six individuals prior to- and following in-vitro exposure to genotoxic agents: hydrogen peroxide and ultraviolet B. This study is the first to report reproducible distinct hierarchical radial organization of chromosomes with little inter-individual differences between subjects. Perturbed nuclear organization was observed following genotoxic exposure for both agents; however a greater effect was observed for hydrogen peroxide including: 1 More peripheral radial organization; 2 Alterations in the global distribution of chromosomes; and 3 More events of chromosome repositioning (18 events involving 10 chromosomes vs. 11 events involving 9 chromosomes for hydrogen peroxide and ultraviolet B respectively. Evidence is provided of chromosome repositioning and altered nuclear organization following in-vitro exposure to genotoxic agents, with notable differences observed between the two investigated agents. Repositioning of chromosomes following genotoxicity involved recurrent chromosomes and is most likely part of the genomes inherent response to DNA damage. The variances in nuclear organization observed between the two agents likely reflects differences in mobility and/or decondensation of chromatin as a result of differences in the type of DNA damage induced, chromatin regions targeted, and DNA repair mechanisms.

Cases requiring increased number of repositioning maneuvers in benign paroxysmal positional vertigo

OpenAIRE

Korkmaz, Mukadder; Korkmaz, Hakan

2016-01-01

ABSTRACT INTRODUCTION: Benign paroxysmal positional vertigo (BPPV) is a clinical syndrome that is proposed to be caused by dislocated utricular debris into semicircular canals. Although the majority of patients are treated by one or two repositioning maneuvers, some of the patients need repeated maneuvers for relief. OBJECTIVE: The goal of this study was to investigate the factors associated with patients with benign paroxysmal positional vertigo who required multiple repositioning proced...

Landform classification using a sub-pixel spatial attraction model to increase spatial resolution of digital elevation model (DEM

Directory of Open Access Journals (Sweden)

Marzieh Mokarrama

2018-04-01

Full Text Available The purpose of the present study is preparing a landform classification by using digital elevation model (DEM which has a high spatial resolution. To reach the mentioned aim, a sub-pixel spatial attraction model was used as a novel method for preparing DEM with a high spatial resolution in the north of Darab, Fars province, Iran. The sub-pixel attraction models convert the pixel into sub-pixels based on the neighboring pixels fraction values, which can only be attracted by a central pixel. Based on this approach, a mere maximum of eight neighboring pixels can be selected for calculating of the attraction value. In the mentioned model, other pixels are supposed to be far from the central pixel to receive any attraction. In the present study by using a sub-pixel attraction model, the spatial resolution of a DEM was increased. The design of the algorithm is accomplished by using a DEM with a spatial resolution of 30 m (the Advanced Space borne Thermal Emission and Reflection Radiometer; (ASTER and a 90 m (the Shuttle Radar Topography Mission; (SRTM. In the attraction model, scale factors of (S = 2, S = 3, and S = 4 with two neighboring methods of touching (T = 1 and quadrant (T = 2 are applied to the DEMs by using MATLAB software. The algorithm is evaluated by taking the best advantages of 487 sample points, which are measured by surveyors. The spatial attraction model with scale factor of (S = 2 gives better results compared to those scale factors which are greater than 2. Besides, the touching neighborhood method is turned to be more accurate than the quadrant method. In fact, dividing each pixel into more than two sub-pixels decreases the accuracy of the resulted DEM. On the other hand, in these cases DEM, is itself in charge of increasing the value of root-mean-square error (RMSE and shows that attraction models could not be used for S which is greater than 2. Thus considering results, the proposed model is highly capable of

Estimation of urban surface water at subpixel level from neighborhood pixels using multispectral remote sensing image (Conference Presentation)

Science.gov (United States)

Xie, Huan; Luo, Xin; Xu, Xiong; Wang, Chen; Pan, Haiyan; Tong, Xiaohua; Liu, Shijie

2016-10-01

Water body is a fundamental element in urban ecosystems and water mapping is critical for urban and landscape planning and management. As remote sensing has increasingly been used for water mapping in rural areas, this spatially explicit approach applied in urban area is also a challenging work due to the water bodies mainly distributed in a small size and the spectral confusion widely exists between water and complex features in the urban environment. Water index is the most common method for water extraction at pixel level, and spectral mixture analysis (SMA) has been widely employed in analyzing urban environment at subpixel level recently. In this paper, we introduce an automatic subpixel water mapping method in urban areas using multispectral remote sensing data. The objectives of this research consist of: (1) developing an automatic land-water mixed pixels extraction technique by water index; (2) deriving the most representative endmembers of water and land by utilizing neighboring water pixels and adaptive iterative optimal neighboring land pixel for respectively; (3) applying a linear unmixing model for subpixel water fraction estimation. Specifically, to automatically extract land-water pixels, the locally weighted scatter plot smoothing is firstly used to the original histogram curve of WI image . And then the Ostu threshold is derived as the start point to select land-water pixels based on histogram of the WI image with the land threshold and water threshold determination through the slopes of histogram curve . Based on the previous process at pixel level, the image is divided into three parts: water pixels, land pixels, and mixed land-water pixels. Then the spectral mixture analysis (SMA) is applied to land-water mixed pixels for water fraction estimation at subpixel level. With the assumption that the endmember signature of a target pixel should be more similar to adjacent pixels due to spatial dependence, the endmember of water and land are determined

Adaptive prostate IGRT combining online re-optimization and re-positioning: a feasibility study

International Nuclear Information System (INIS)

Li Taoran; Zhu Xiaofeng; Lee, W Robert; Vujaskovic, Zeljko; Yin Fangfang; Wu, Q Jackie; Thongphiew, Danthai

2011-01-01

In prostate radiation therapy, inter-fractional organ motion/deformation has posed significant challenges on reliable daily dose delivery. To correct for this issue, off-line re-optimization and online re-positioning have been used clinically. In this paper, we propose an adaptive images guided radiation therapy (AIGRT) scheme that combines these two correction methods in an anatomy-driven fashion. The AIGRT process first tries to find a best plan for the daily target from a plan pool, which consists of the original CT plan and all previous re-optimized plans. If successful, the selected plan is used for daily treatment with translational shifts. Otherwise, the AIGRT invokes the re-optimization process of the CT plan for the anatomy of the day, which is afterward added to the plan pool as a candidate for future fractions. The AIGRT scheme is evaluated by comparisons with daily re-optimization and online re-positioning techniques based on daily target coverage, organs at risk (OAR) sparing and implementation efficiency. Simulated treatment courses for 18 patients with re-optimization alone, re-positioning alone and AIGRT shows that AIGRT offers reliable daily target coverage that is highly comparable to daily re-optimization and significantly improves from re-positioning. AIGRT is also seen to provide improved OAR sparing compared to re-positioning. Apart from dosimetric benefits, AIGRT in addition offers an efficient scheme to integrate re-optimization to current re-positioning-based IGRT workflow.

Drug Repositioning: An Opportunity to Develop Novel Treatments for Alzheimer’s Disease

Directory of Open Access Journals (Sweden)

Clive Ballard

2013-10-01

Full Text Available Alzheimer’s Disease (AD is the most common cause of dementia, affecting approximately two thirds of the 35 million people worldwide with the condition. Despite this, effective treatments are lacking, and there are no drugs that elicit disease modifying effects to improve outcome. There is an urgent need to develop and evaluate more effective pharmacological treatments. Drug repositioning offers an exciting opportunity to repurpose existing licensed treatments for use in AD, with the benefit of providing a far more rapid route to the clinic than through novel drug discovery approaches. This review outlines the current most promising candidates for repositioning in AD, their supporting evidence and their progress through trials to date. Furthermore, it begins to explore the potential of new transcriptomic and microarray techniques to consider the future of drug repositioning as a viable approach to drug discovery.

Subpixel edge estimation with lens aberrations compensation based on the iterative image approximation for high-precision thermal expansion measurements of solids

Science.gov (United States)

Inochkin, F. M.; Kruglov, S. K.; Bronshtein, I. G.; Kompan, T. A.; Kondratjev, S. V.; Korenev, A. S.; Pukhov, N. F.

2017-06-01

A new method for precise subpixel edge estimation is presented. The principle of the method is the iterative image approximation in 2D with subpixel accuracy until the appropriate simulated is found, matching the simulated and acquired images. A numerical image model is presented consisting of three parts: an edge model, object and background brightness distribution model, lens aberrations model including diffraction. The optimal values of model parameters are determined by means of conjugate-gradient numerical optimization of a merit function corresponding to the L2 distance between acquired and simulated images. Computationally-effective procedure for the merit function calculation along with sufficient gradient approximation is described. Subpixel-accuracy image simulation is performed in a Fourier domain with theoretically unlimited precision of edge points location. The method is capable of compensating lens aberrations and obtaining the edge information with increased resolution. Experimental method verification with digital micromirror device applied to physically simulate an object with known edge geometry is shown. Experimental results for various high-temperature materials within the temperature range of 1000°C..2400°C are presented.

Improved initial guess with semi-subpixel level accuracy in digital image correlation by feature-based method

Science.gov (United States)

Zhang, Yunlu; Yan, Lei; Liou, Frank

2018-05-01

The quality initial guess of deformation parameters in digital image correlation (DIC) has a serious impact on convergence, robustness, and efficiency of the following subpixel level searching stage. In this work, an improved feature-based initial guess (FB-IG) scheme is presented to provide initial guess for points of interest (POIs) inside a large region. Oriented FAST and Rotated BRIEF (ORB) features are semi-uniformly extracted from the region of interest (ROI) and matched to provide initial deformation information. False matched pairs are eliminated by the novel feature guided Gaussian mixture model (FG-GMM) point set registration algorithm, and nonuniform deformation parameters of the versatile reproducing kernel Hilbert space (RKHS) function are calculated simultaneously. Validations on simulated images and real-world mini tensile test verify that this scheme can robustly and accurately compute initial guesses with semi-subpixel level accuracy in cases with small or large translation, deformation, or rotation.

Intermodal Transport and Repositioning of Empty Containers in Central and Eastern Europe Hinterland

DEFF Research Database (Denmark)

Kolar, Petr; Schramm, Hans-Joachim; Prockl, Günter

2018-01-01

The objective of this article is to provide a review of literature dealing with empty container repositioning. This review is interlinked with a qualitative data analysis based on semi-structured interviews with representatives of ocean carriers, which are key actors determining empty container....... By addressing the research questions and conducting the analysis, the authors determine whether empty container repositioning is a problem only concerning equipment allocation by an ocean carrier or requires a collaborative resolution involving various parties engaged in container movements in landlocked...... hinterlands. This article confirms that most existing literature dealing with empty container repositioning ignores the actual dynamics of landlocked hinterlands as well as business practitioners' perspective. The authors' analysis of the empirical research complements and challenges the reviewed research...

In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases.

Science.gov (United States)

Andrade, Carolina Horta; Neves, Bruno Junior; Melo-Filho, Cleber Camilo; Rodrigues, Juliana; Silva, Diego Cabral; Braga, Rodolpho Campos; Cravo, Pedro Vitor Lemos

2018-03-08

Only ~1% of all drug candidates against Neglected Tropical Diseases (NTDs) have reached clinical trials in the last decades, underscoring the need for new, safe and effective treatments. In such context, drug repositioning, which allows finding novel indications for approved drugs whose pharmacokinetic and safety profiles are already known, is emerging as a promising strategy for tackling NTDs. Chemogenomics is a direct descendent of the typical drug discovery process that involves the systematic screening of chemical compounds against drug targets in high-throughput screening (HTS) efforts, for the identification of lead compounds. However, different to the one-drug-one-target paradigm, chemogenomics attempts to identify all potential ligands for all possible targets and diseases. In this review, we summarize current methodological development efforts in drug repositioning that use state-of-the-art computational ligand- and structure-based chemogenomics approaches. Furthermore, we highlighted the recent progress in computational drug repositioning for some NTDs, based on curation and modeling of genomic, biological, and chemical data. Additionally, we also present in-house and other successful examples and suggest possible solutions to existing pitfalls. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Canal switch after canalith repositioning procedure for benign paroxysmal positional vertigo.

Science.gov (United States)

Lin, Giant C; Basura, Gregory J; Wong, Hiu Tung; Heidenreich, Katherine D

2012-09-01

Canal switch is a complication following canalith repositioning procedure (CRP) for posterior canal benign paroxysmal positional vertigo (BPPV). Instead of being returned to the utricle, the loose otoconia migrate into the superior or horizontal semicircular canal. Patients remain symptomatic, and treatment can be ineffective unless the switch is recognized and additional repositioning maneuvers directed toward the appropriate semicircular canal are performed. This report provides the first videographic documentation of canal switch involving conversion of unilateral posterior semicircular canal BPPV to geotropic horizontal canalithiasis. Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.

DrugSig: A resource for computational drug repositioning utilizing gene expression signatures.

Directory of Open Access Journals (Sweden)

Hongyu Wu

Full Text Available Computational drug repositioning has been proved as an effective approach to develop new drug uses. However, currently existing strategies strongly rely on drug response gene signatures which scattered in separated or individual experimental data, and resulted in low efficient outputs. So, a fully drug response gene signatures database will be very helpful to these methods. We collected drug response microarray data and annotated related drug and targets information from public databases and scientific literature. By selecting top 500 up-regulated and down-regulated genes as drug signatures, we manually established the DrugSig database. Currently DrugSig contains more than 1300 drugs, 7000 microarray and 800 targets. Moreover, we developed the signature based and target based functions to aid drug repositioning. The constructed database can serve as a resource to quicken computational drug repositioning. Database URL: http://biotechlab.fudan.edu.cn/database/drugsig/.

Comparison of BiLinearly Interpolated Subpixel Sensitivity Mapping and Pixel-Level Decorrelation

Science.gov (United States)

Challener, Ryan C.; Harrington, Joseph; Cubillos, Patricio; Foster, Andrew S.; Deming, Drake; WASP Consortium

2016-10-01

Exoplanet eclipse signals are weaker than the systematics present in the Spitzer Space Telescope's Infrared Array Camera (IRAC), and thus the correction method can significantly impact a measurement. BiLinearly Interpolated Subpixel Sensitivity (BLISS) mapping calculates the sensitivity of the detector on a subpixel grid and corrects the photometry for any sensitivity variations. Pixel-Level Decorrelation (PLD) removes the sensitivity variations by considering the relative intensities of the pixels around the source. We applied both methods to WASP-29b, a Saturn-sized planet with a mass of 0.24 ± 0.02 Jupiter masses and a radius of 0.84 ± 0.06 Jupiter radii, which we observed during eclipse twice with the 3.6 µm and once with the 4.5 µm channels of IRAC aboard Spitzer in 2010 and 2011 (programs 60003 and 70084, respectively). We compared the results of BLISS and PLD, and comment on each method's ability to remove time-correlated noise. WASP-29b exhibits a strong detection at 3.6 µm and no detection at 4.5 µm. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Realizing drug repositioning by adapting a recommendation system to handle the process.

Science.gov (United States)

Ozsoy, Makbule Guclin; Özyer, Tansel; Polat, Faruk; Alhajj, Reda

2018-04-12

Drug repositioning is the process of identifying new targets for known drugs. It can be used to overcome problems associated with traditional drug discovery by adapting existing drugs to treat new discovered diseases. Thus, it may reduce associated risk, cost and time required to identify and verify new drugs. Nowadays, drug repositioning has received more attention from industry and academia. To tackle this problem, researchers have applied many different computational methods and have used various features of drugs and diseases. In this study, we contribute to the ongoing research efforts by combining multiple features, namely chemical structures, protein interactions and side-effects to predict new indications of target drugs. To achieve our target, we realize drug repositioning as a recommendation process and this leads to a new perspective in tackling the problem. The utilized recommendation method is based on Pareto dominance and collaborative filtering. It can also integrate multiple data-sources and multiple features. For the computation part, we applied several settings and we compared their performance. Evaluation results show that the proposed method can achieve more concentrated predictions with high precision, where nearly half of the predictions are true. Compared to other state of the art methods described in the literature, the proposed method is better at making right predictions by having higher precision. The reported results demonstrate the applicability and effectiveness of recommendation methods for drug repositioning.

Repositioning teaching in Nigerian secondary schools using media ...

African Journals Online (AJOL)

Repositioning teaching in Nigerian secondary schools using media resources in a digital age. ... Lagos Journal of Library and Information Science ... that the new tools served as an added advantage on the traditional method of teaching and learning, especially in information delivery; channelled through media resources.

A robust sub-pixel edge detection method of infrared image based on tremor-based retinal receptive field model

Science.gov (United States)

Gao, Kun; Yang, Hu; Chen, Xiaomei; Ni, Guoqiang

2008-03-01

Because of complex thermal objects in an infrared image, the prevalent image edge detection operators are often suitable for a certain scene and extract too wide edges sometimes. From a biological point of view, the image edge detection operators work reliably when assuming a convolution-based receptive field architecture. A DoG (Difference-of- Gaussians) model filter based on ON-center retinal ganglion cell receptive field architecture with artificial eye tremors introduced is proposed for the image contour detection. Aiming at the blurred edges of an infrared image, the subsequent orthogonal polynomial interpolation and sub-pixel level edge detection in rough edge pixel neighborhood is adopted to locate the foregoing rough edges in sub-pixel level. Numerical simulations show that this method can locate the target edge accurately and robustly.

A Framework Based on 2-D Taylor Expansion for Quantifying the Impacts of Subpixel Reflectance Variance and Covariance on Cloud Optical Thickness and Effective Radius Retrievals Based on the Bispectral Method

Science.gov (United States)

Zhang, Z.; Werner, F.; Cho, H.-M.; Wind, G.; Platnick, S.; Ackerman, A. S.; Di Girolamo, L.; Marshak, A.; Meyer, K.

2016-01-01

The bispectral method retrieves cloud optical thickness (t) and cloud droplet effective radius (re) simultaneously from a pair of cloud reflectance observations, one in a visible or near-infrared (VIS/NIR) band and the other in a shortwave infrared (SWIR) band. A cloudy pixel is usually assumed to be horizontally homogeneous in the retrieval. Ignoring subpixel variations of cloud reflectances can lead to a significant bias in the retrieved t and re. In the literature, the retrievals of t and re are often assumed to be independent and considered separately when investigating the impact of subpixel cloud reflectance variations on the bispectral method. As a result, the impact on t is contributed only by the subpixel variation of VIS/NIR band reflectance and the impact on re only by the subpixel variation of SWIR band reflectance. In our new framework, we use the Taylor expansion of a two-variable function to understand and quantify the impacts of subpixel variances of VIS/NIR and SWIR cloud reflectances and their covariance on the t and re retrievals. This framework takes into account the fact that the retrievals are determined by both VIS/NIR and SWIR band observations in a mutually dependent way. In comparison with previous studies, it provides a more comprehensive understanding of how subpixel cloud reflectance variations impact the t and re retrievals based on the bispectral method. In particular, our framework provides a mathematical explanation of how the subpixel variation in VIS/NIR band influences the re retrieval and why it can sometimes outweigh the influence of variations in the SWIR band and dominate the error in re retrievals, leading to a potential contribution of positive bias to the re retrieval. We test our framework using synthetic cloud fields from a large-eddy simulation and real observations from Moderate Resolution Imaging Spectroradiometer. The predicted results based on our framework agree very well with the numerical simulations. Our

[Computer assisted orthognathic surgery: Condyle repositioning.

Science.gov (United States)

Bettega, G; Leitner, F

2013-07-17

Computer aided surgery has become a standard in many fields. It is rarely used in orthognathic surgery. Twenty years ago, we developed a navigation system adapted to this surgery, especially for mandibular condyle repositioning. The system has been improved along with technological progress. The authors of several clinical studies have validated this system. It is now routinely used in our department, because of its educational virtues among other assets. Copyright © 2013. Published by Elsevier Masson SAS.

Characterizing sub-pixel landsat ETM plus fire severity on experimental fires in the Kruger National Park, South Africa

CSIR Research Space (South Africa)

Landmann, T

2003-07-01

Full Text Available Burn severity was quantitatively mapped using a unique linear spectral mixture model to determine sub-pixel abundances of different ashes and combustion completeness measured on the corresponding fire-affected pixels in Landsat data. A new burn...

Fractionated brain stereotactic radiotherapy: assessment of repositioning precision using a thermoforming mask

International Nuclear Information System (INIS)

Barret, A.; Champeaux-Orange, E.; Bouscayrol, H.; Wachter, T.

2011-01-01

The authors report a study which aimed at assessing the patient repositioning precision obtained with a support system used during a brain fractionated stereotactic radiotherapy and comprising a thermoforming mask (Elektra head mask). The repositioning is assessed by means of scano-graphies and superimposition with the stereotactic frame. A three-dimensional vector has been computed for each patient. The average displacement corresponds to that published in literature. The high quality of the support system allows a non invasive brain stereotactic radiotherapy to be performed which is also comfortable for the patient. Short communication

The comparison of cervical repositioning errors according to smartphone addiction grades.

Science.gov (United States)

Lee, Jeonhyeong; Seo, Kyochul

2014-04-01

[Purpose] The purpose of this study was to compare cervical repositioning errors according to smartphone addiction grades of adults in their 20s. [Subjects and Methods] A survey of smartphone addiction was conducted of 200 adults. Based on the survey results, 30 subjects were chosen to participate in this study, and they were divided into three groups of 10; a Normal Group, a Moderate Addiction Group, and a Severe Addiction Group. After attaching a C-ROM, we measured the cervical repositioning errors of flexion, extension, right lateral flexion and left lateral flexion. [Results] Significant differences in the cervical repositioning errors of flexion, extension, and right and left lateral flexion were found among the Normal Group, Moderate Addiction Group, and Severe Addiction Group. In particular, the Severe Addiction Group showed the largest errors. [Conclusion] The result indicates that as smartphone addiction becomes more severe, a person is more likely to show impaired proprioception, as well as impaired ability to recognize the right posture. Thus, musculoskeletal problems due to smartphone addiction should be resolved through social cognition and intervention, and physical therapeutic education and intervention to educate people about correct postures.

Estimation bias from using nonlinear Fourier plane correlators for sub-pixel image shift measurement and implications for the binary joint transform correlator

Science.gov (United States)

Grycewicz, Thomas J.; Florio, Christopher J.; Franz, Geoffrey A.; Robinson, Ross E.

2007-09-01

When using Fourier plane digital algorithms or an optical correlator to measure the correlation between digital images, interpolation by center-of-mass or quadratic estimation techniques can be used to estimate image displacement to the sub-pixel level. However, this can lead to a bias in the correlation measurement. This bias shifts the sub-pixel output measurement to be closer to the nearest pixel center than the actual location. The paper investigates the bias in the outputs of both digital and optical correlators, and proposes methods to minimize this effect. We use digital studies and optical implementations of the joint transform correlator to demonstrate optical registration with accuracies better than 0.1 pixels. We use both simulations of image shift and movies of a moving target as inputs. We demonstrate bias error for both center-of-mass and quadratic interpolation, and discuss the reasons that this bias is present. Finally, we suggest measures to reduce or eliminate the bias effects. We show that when sub-pixel bias is present, it can be eliminated by modifying the interpolation method. By removing the bias error, we improve registration accuracy by thirty percent.

A Framework Based on 2-D Taylor Expansion for Quantifying the Impacts of Sub-Pixel Reflectance Variance and Covariance on Cloud Optical Thickness and Effective Radius Retrievals Based on the Bi-Spectral Method

Science.gov (United States)

Zhang, Z.; Werner, F.; Cho, H. -M.; Wind, G.; Platnick, S.; Ackerman, A. S.; Di Girolamo, L.; Marshak, A.; Meyer, Kerry

2016-01-01

The bi-spectral method retrieves cloud optical thickness and cloud droplet effective radius simultaneously from a pair of cloud reflectance observations, one in a visible or near-infrared (VISNIR) band and the other in a shortwave infrared (SWIR) band. A cloudy pixel is usually assumed to be horizontally homogeneous in the retrieval. Ignoring sub-pixel variations of cloud reflectances can lead to a significant bias in the retrieved and re. In the literature, the retrievals of and re are often assumed to be independent and considered separately when investigating the impact of sub-pixel cloud reflectance variations on the bi-spectral method. As a result, the impact on is contributed only by the sub-pixel variation of VISNIR band reflectance and the impact on re only by the sub-pixel variation of SWIR band reflectance. In our new framework, we use the Taylor expansion of a two-variable function to understand and quantify the impacts of sub-pixel variances of VISNIR and SWIR cloud reflectances and their covariance on the and re retrievals. This framework takes into account the fact that the retrievals are determined by both VISNIR and SWIR band observations in a mutually dependent way. In comparison with previous studies, it provides a more comprehensive understanding of how sub-pixel cloud reflectance variations impact the and re retrievals based on the bi-spectral method. In particular, our framework provides a mathematical explanation of how the sub-pixel variation in VISNIR band influences the re retrieval and why it can sometimes outweigh the influence of variations in the SWIR band and dominate the error in re retrievals, leading to a potential contribution of positive bias to the re retrieval. We test our framework using synthetic cloud fields from a large-eddy simulation and real observations from Moderate Resolution Imaging Spectroradiometer. The predicted results based on our framework agree very well with the numerical simulations. Our framework can be used

Fractionated stereotactic irradiation by Cyberknife of choroid melanomas: repositioning validation, closed eyelids

International Nuclear Information System (INIS)

Horn, S.; Rezvoy, N.; Lacornerie, T.; Mirabel, X.; Labalette, P.; Lartigau, E.

2009-01-01

The fractionated stereotactic radiotherapy by Cyberknife is an option in the treatment of eyes tumors. The advantages of the Cyberknife in the choroid melanomas are in its infra-millimetric precision, to the automated repositioning on the skull bones and to the conformity brought by the stereotaxy. The objective of this study was to validate the quality of repositioning and the immobility of the eyes with closed eyelids. Conclusion: the reproducibility of the eye positioning with closed eyelids seems enough to consider the conservative treatment of choroid melanomas by fractionated stereotactic radiotherapy by Cyberknife without implementation of fiducials nor retrobulbar anaesthesia. (N.C.)

Subpixel mapping and test beam studies with a HV2FEI4v2 CMOS-Sensor-Hybrid Module for the ATLAS inner detector upgrade

Science.gov (United States)

Bisanz, T.; Große-Knetter, J.; Quadt, A.; Rieger, J.; Weingarten, J.

2017-08-01

The upgrade to the High Luminosity Large Hadron Collider will increase the instantaneous luminosity by more than a factor of 5, thus creating significant challenges to the tracking systems of all experiments. Recent advancement of active pixel detectors designed in CMOS processes provide attractive alternatives to the well-established hybrid design using passive sensors since they allow for smaller pixel sizes and cost effective production. This article presents studies of a high-voltage CMOS active pixel sensor designed for the ATLAS tracker upgrade. The sensor is glued to the read-out chip of the Insertable B-Layer, forming a capacitively coupled pixel detector. The pixel pitch of the device under test is 33× 125 μm2, while the pixels of the read-out chip have a pitch of 50× 250 μm2. Three pixels of the CMOS device are connected to one read-out pixel, the information of which of these subpixels is hit is encoded in the amplitude of the output signal (subpixel encoding). Test beam measurements are presented that demonstrate the usability of this subpixel encoding scheme.

EMUDRA: Ensemble of Multiple Drug Repositioning Approaches to Improve Prediction Accuracy.

Science.gov (United States)

Zhou, Xianxiao; Wang, Minghui; Katsyv, Igor; Irie, Hanna; Zhang, Bin

2018-04-24

Availability of large-scale genomic, epigenetic and proteomic data in complex diseases makes it possible to objectively and comprehensively identify therapeutic targets that can lead to new therapies. The Connectivity Map has been widely used to explore novel indications of existing drugs. However, the prediction accuracy of the existing methods, such as Kolmogorov-Smirnov statistic remains low. Here we present a novel high-performance drug repositioning approach that improves over the state-of-the-art methods. We first designed an expression weighted cosine method (EWCos) to minimize the influence of the uninformative expression changes and then developed an ensemble approach termed EMUDRA (Ensemble of Multiple Drug Repositioning Approaches) to integrate EWCos and three existing state-of-the-art methods. EMUDRA significantly outperformed individual drug repositioning methods when applied to simulated and independent evaluation datasets. We predicted using EMUDRA and experimentally validated an antibiotic rifabutin as an inhibitor of cell growth in triple negative breast cancer. EMUDRA can identify drugs that more effectively target disease gene signatures and will thus be a useful tool for identifying novel therapies for complex diseases and predicting new indications for existing drugs. The EMUDRA R package is available at doi:10.7303/syn11510888. bin.zhang@mssm.edu or zhangb@hotmail.com. Supplementary data are available at Bioinformatics online.

Role of image-guided patient repositioning and online planning in localized prostate cancer IMRT

International Nuclear Information System (INIS)

Lerma, Fritz A.; Liu, Bei; Wang, Zhendong; Yi, Byongyong; Amin, Pradip; Liu, Sandy; Feng Yuanming; Yu, Cedric X.

2009-01-01

Purpose: To determine the expected benefit of image-guided online replanning over image-guided repositioning of localized prostate cancer intensity-modulated radiotherapy (IMRT). Materials and methods: On 10 to 11 CT scans of each of 10 early-stage prostate cancer patients, the prostate, bladder and rectum are manually segmented. Using a 3-mm PTV margin expansion from the CTV, an IMRT plan is made on the first CT scan of each patient. Online repositioning is simulated by recalculating the IMRT plan from the initial CT scan on the subsequent CT scans of each patient. For online replanning, IMRT is replanned twice on all CT scans, using 0-mm and 3-mm margins. The doses from subsequent CT images of each patient are then deformed to the initial CT anatomy using a mesh-based thin-plate B-spline deformation method and are accumulated for DVH and isodose review. Results: Paired t-tests show that online replanning with 3-mm margins significantly increases the prostate volume receiving the prescribed dose over replanning with 0-mm margins (p-value 0.004); gives marginally better target coverage than repositioning with 3-mm margins(p-value 0.06-0.343), and reduces variations in target coverage over repositioning. Fractional volumes of rectum and bladder receiving 75%, 80%, 85%, 90%, and 95% (V75, V80, V85, V90, and V95) of the prescription dose are evaluated. V90 and V95 values for the rectum are 1.6% and 0.7 % for 3-mm margin replanning and 1% and 0.4 % for 0-mm margin replanning, with p-values of 0.010-0.011. No significant differences between repositioning and replanning with 3-mm margins are found for both the rectum and the bladder. Conclusions: Image-guided replanning using 3-mm margins reduces target coverage variations, and maintains comparable rectum and bladder sparing to patient repositioning in localized prostate cancer IMRT. Marginal reductions in doses to rectum and bladder are possible when planning margins are eliminated in the online replanning scenario

Solving a static repositioning problem in bike-sharing systems using iterated tabu search

DEFF Research Database (Denmark)

Ho, Sin C.; Szeto, W. Y.

2014-01-01

In this paper, we study the static bike repositioning problem where the problem consists of selecting a subset of stations to visit, sequencing them, and determining the pick-up/drop-off quantities (associated with each of the visited stations) under the various operational constraints. The objec......In this paper, we study the static bike repositioning problem where the problem consists of selecting a subset of stations to visit, sequencing them, and determining the pick-up/drop-off quantities (associated with each of the visited stations) under the various operational constraints...

Characterizing Subpixel Spatial Resolution of a Hybrid CMOS Detector

Science.gov (United States)

Bray, Evan; Burrows, Dave; Chattopadhyay, Tanmoy; Falcone, Abraham; Hull, Samuel; Kern, Matthew; McQuaide, Maria; Wages, Mitchell

2018-01-01

The detection of X-rays is a unique process relative to other wavelengths, and allows for some novel features that increase the scientific yield of a single observation. Unlike lower photon energies, X-rays liberate a large number of electrons from the silicon absorber array of the detector. This number is usually on the order of several hundred to a thousand for moderate-energy X-rays. These electrons tend to diffuse outward into what is referred to as the charge cloud. This cloud can then be picked up by several pixels, forming a specific pattern based on the exact incident location. By conducting the first ever “mesh experiment" on a hybrid CMOS detector (HCD), we have experimentally determined the charge cloud shape and used it to characterize responsivity of the detector with subpixel spatial resolution.

Repositioning the knee joint in human body FE models using a graphics-based technique.

Science.gov (United States)

Jani, Dhaval; Chawla, Anoop; Mukherjee, Sudipto; Goyal, Rahul; Vusirikala, Nataraju; Jayaraman, Suresh

2012-01-01

Human body finite element models (FE-HBMs) are available in standard occupant or pedestrian postures. There is a need to have FE-HBMs in the same posture as a crash victim or to be configured in varying postures. Developing FE models for all possible positions is not practically viable. The current work aims at obtaining a posture-specific human lower extremity model by reconfiguring an existing one. A graphics-based technique was developed to reposition the lower extremity of an FE-HBM by specifying the flexion-extension angle. Elements of the model were segregated into rigid (bones) and deformable components (soft tissues). The bones were rotated about the flexion-extension axis followed by rotation about the longitudinal axis to capture the twisting of the tibia. The desired knee joint movement was thus achieved. Geometric heuristics were then used to reposition the skin. A mapping defined over the space between bones and the skin was used to regenerate the soft tissues. Mesh smoothing was then done to augment mesh quality. The developed method permits control over the kinematics of the joint and maintains the initial mesh quality of the model. For some critical areas (in the joint vicinity) where element distortion is large, mesh smoothing is done to improve mesh quality. A method to reposition the knee joint of a human body FE model was developed. Repositions of a model from 9 degrees of flexion to 90 degrees of flexion in just a few seconds without subjective interventions was demonstrated. Because the mesh quality of the repositioned model was maintained to a predefined level (typically to the level of a well-made model in the initial configuration), the model was suitable for subsequent simulations.

Repositioning accuracy: Comparison of a noninvasive head holder with thermoplastic mask for fractionated radiotherapy and a case report

International Nuclear Information System (INIS)

Sweeney, Reinhart; Bale, Reto; Vogele, Michael; Nevinny-Stickel, Meinhart; Bluhm, Anja; Auer, Thomas; Hessenberger, Gerhart; Lukas, Peter

1998-01-01

Purpose: To compare accuracy, clinical feasibility, and subjective patient impression between a noninvasive head holder (Vogele Bale Hohner [VBH]; Wellhoefer Dosimetry, Schwarzenbruck, Germany) developed at the University of Innsbruck and the thermoplastic mask fixation system for use in fractionated external radiotherapy. We present a case report of an actual patient fixated in the VBH head holder during radiation therapy. Materials and Methods: The VBH head holder consists of an individualized vacuum dental cast connected to a head plate via two hydraulic arms allowing noninvasive, reproducible head fixation of even uncooperative patients. Accuracy was tested and compared with that of the thermoplastic mask using the Phillips EasyGuide navigation system on five volunteers. Specific external registration points served as landmarks and their positions were compared after each repositioning. System and operator inaccuracy were also taken into account. The times taken for production and repositioning of the respective fixation devices were compared, and subjective impressions were noted. Results: Mean VBH head holder repositioning accuracy was 1.02 mm while that of the thermoplastic mask was 3.05 mm. 69% of mask repositionings showed a deviation > 2 mm and 41% > 3 mm (as opposed to 8% and 1% respectively for the VBH head holder) Those points located farthest away from the respective plane of fixation showed the largest deviations. Both production and repositioning times were similar between the systems; depending upon the patient, the VBH head holder was generally better tolerated than the mask system. Conclusion: Due to its significantly better repositioning accuracy compared to that of the thermoplastic mask, the VBH head holder is especially suited for external radiation requiring precise repositioning due to critical tissues in immediate surrounding of the area to be irradiated

A Framework for Quantifying the Impacts of Sub-Pixel Reflectance Variance and Covariance on Cloud Optical Thickness and Effective Radius Retrievals Based on the Bi-Spectral Method.

Science.gov (United States)

Zhang, Z; Werner, F.; Cho, H. -M.; Wind, Galina; Platnick, S.; Ackerman, A. S.; Di Girolamo, L.; Marshak, A.; Meyer, Kerry

2017-01-01

The so-called bi-spectral method retrieves cloud optical thickness (t) and cloud droplet effective radius (re) simultaneously from a pair of cloud reflectance observations, one in a visible or near infrared (VIS/NIR) band and the other in a shortwave-infrared (SWIR) band. A cloudy pixel is usually assumed to be horizontally homogeneous in the retrieval. Ignoring sub-pixel variations of cloud reflectances can lead to a significant bias in the retrieved t and re. In this study, we use the Taylor expansion of a two-variable function to understand and quantify the impacts of sub-pixel variances of VIS/NIR and SWIR cloud reflectances and their covariance on the t and re retrievals. This framework takes into account the fact that the retrievals are determined by both VIS/NIR and SWIR band observations in a mutually dependent way. In comparison with previous studies, it provides a more comprehensive understanding of how sub-pixel cloud reflectance variations impact the t and re retrievals based on the bi-spectral method. In particular, our framework provides a mathematical explanation of how the sub-pixel variation in VIS/NIR band influences the re retrieval and why it can sometimes outweigh the influence of variations in the SWIR band and dominate the error in re retrievals, leading to a potential contribution of positive bias to the re retrieval.

Early repositioning through compound set enrichment analysis: a knowledge-recycling strategy.

Science.gov (United States)

Temesi, Gergely; Bolgár, Bence; Arany, Adám; Szalai, Csaba; Antal, Péter; Mátyus, Péter

2014-04-01

Despite famous serendipitous drug repositioning success stories, systematic projects have not yet delivered the expected results. However, repositioning technologies are gaining ground in different phases of routine drug development, together with new adaptive strategies. We demonstrate the power of the compound information pool, the ever-growing heterogeneous information repertoire of approved drugs and candidates as an invaluable catalyzer in this transition. Systematic, computational utilization of this information pool for candidates in early phases is an open research problem; we propose a novel application of the enrichment analysis statistical framework for fusion of this information pool, specifically for the prediction of indications. Pharmaceutical consequences are formulated for a systematic and continuous knowledge recycling strategy, utilizing this information pool throughout the drug-discovery pipeline.

Repositioning reference new methods and new services for a new age

CERN Document Server

Rozaklis, Lillian

2014-01-01

Repositioning Reference reimagines reference services in libraries and information organizations and the role of reference librarians, taking into account rapid developments in technology and information-specific services in non-library sectors.

Thorough statistical comparison of machine learning regression models and their ensembles for sub-pixel imperviousness and imperviousness change mapping

Directory of Open Access Journals (Sweden)

Drzewiecki Wojciech

2017-12-01

Full Text Available We evaluated the performance of nine machine learning regression algorithms and their ensembles for sub-pixel estimation of impervious areas coverages from Landsat imagery. The accuracy of imperviousness mapping in individual time points was assessed based on RMSE, MAE and R2. These measures were also used for the assessment of imperviousness change intensity estimations. The applicability for detection of relevant changes in impervious areas coverages at sub-pixel level was evaluated using overall accuracy, F-measure and ROC Area Under Curve. The results proved that Cubist algorithm may be advised for Landsat-based mapping of imperviousness for single dates. Stochastic gradient boosting of regression trees (GBM may be also considered for this purpose. However, Random Forest algorithm is endorsed for both imperviousness change detection and mapping of its intensity. In all applications the heterogeneous model ensembles performed at least as well as the best individual models or better. They may be recommended for improving the quality of sub-pixel imperviousness and imperviousness change mapping. The study revealed also limitations of the investigated methodology for detection of subtle changes of imperviousness inside the pixel. None of the tested approaches was able to reliably classify changed and non-changed pixels if the relevant change threshold was set as one or three percent. Also for fi ve percent change threshold most of algorithms did not ensure that the accuracy of change map is higher than the accuracy of random classifi er. For the threshold of relevant change set as ten percent all approaches performed satisfactory.

Thorough statistical comparison of machine learning regression models and their ensembles for sub-pixel imperviousness and imperviousness change mapping

Science.gov (United States)

Drzewiecki, Wojciech

2017-12-01

We evaluated the performance of nine machine learning regression algorithms and their ensembles for sub-pixel estimation of impervious areas coverages from Landsat imagery. The accuracy of imperviousness mapping in individual time points was assessed based on RMSE, MAE and R2. These measures were also used for the assessment of imperviousness change intensity estimations. The applicability for detection of relevant changes in impervious areas coverages at sub-pixel level was evaluated using overall accuracy, F-measure and ROC Area Under Curve. The results proved that Cubist algorithm may be advised for Landsat-based mapping of imperviousness for single dates. Stochastic gradient boosting of regression trees (GBM) may be also considered for this purpose. However, Random Forest algorithm is endorsed for both imperviousness change detection and mapping of its intensity. In all applications the heterogeneous model ensembles performed at least as well as the best individual models or better. They may be recommended for improving the quality of sub-pixel imperviousness and imperviousness change mapping. The study revealed also limitations of the investigated methodology for detection of subtle changes of imperviousness inside the pixel. None of the tested approaches was able to reliably classify changed and non-changed pixels if the relevant change threshold was set as one or three percent. Also for fi ve percent change threshold most of algorithms did not ensure that the accuracy of change map is higher than the accuracy of random classifi er. For the threshold of relevant change set as ten percent all approaches performed satisfactory.

Demonstration of biased membrane static figure mapping by optical beam subpixel centroid shift

Energy Technology Data Exchange (ETDEWEB)

Pinto, Fabrizio, E-mail: fpinto@jazanu.edu.sa [Laboratory for Quantum Vacuum Applications, Department of Physics, Faculty of Science, Jazan University, P.O. Box 114, Gizan 45142 (Saudi Arabia)

2016-06-10

The measurement of Casimir forces by means of condenser microphones has been shown to be quite promising since its early introduction almost half-a-century ago. However, unlike the remarkable progress achieved in characterizing the vibrating membrane in the dynamical case, the accurate determination of the membrane static figure under electrostatic bias remains a challenge. In this paper, we discuss our first data obtained by measuring the centroid shift of an optical beam with subpixel accuracy by charge coupled device (CCD) and by an extensive analysis of noise sources present in the experimental setup.

Development of transducers for integrated garter spring repositioning system

Energy Technology Data Exchange (ETDEWEB)

Sharma, B S.V.G.; Shyam, T V; Shrivastava, A K; Rupani, B B; Sinha, R K [Bhabha Atomic Research Centre, Bombay (India). Reactor Engineering Div.

1994-12-31

In order to reposition the dislocated garter springs in active channels of 235 MW Pressurised Heavy Water Reactors (PHWRs), a tool named as Integrated Garter Spring Repositioning System (INGRES) has been developed. The tool consists of transducers to detect the concentricity between the Pressure Tube (P/T) and Calandria Tube (C/T) and also to detect garter springs in the channel besides different modules for correcting the eccentricity between P/T and C/T and garter spring repositioning. The transducers used in the system namely Concentricity Detection Probe (CDP) and Garter Spring Detection Probe (GSDP) are based on the eddy current techniques. The CDP makes use of four eddy current bobbin probes separated 90 degrees apart in cross sectional plane of channel assembly. The transducer gives output signal in proportional to the air gap between P/T and C/T in two axes (X and Y) which are designed for the purpose. The output of the unit is obtained on the Cathode Ray Oscilloscope (CRO) screen in the form of illuminated dot. The dot position on the CRO screen gives the information about mismatch in concentricity between P/T and C/T of the channel. The GSDP meant for detecting garter springs in PHWR channel uses two sets of primary and secondary coils connected in differential mode. The output signals from the transducers are processed through a signal processing unit devised for the purpose to obtain output from it as a horizontal beam on the CRO screen. The garter spring presence in the channel is indicated by a change in the voltage level of beam and also by audio-visual indication in the form of buzzer and LED illumination on the processing unit. This paper gives general design and development aspects of the CDP and GSDP transducers of the INGRES tool. (author). 3 figs.

The Effect of a Condylar Repositioning Plate on Condylar Position and Relapse in Two-Jaw Surgery

Directory of Open Access Journals (Sweden)

Gyu Sik Jung

2017-01-01

Full Text Available BackgroundNumerous condylar repositioning methods have been reported. However, most of them are 2-dimensional or are complex procedures that require a longer operation time and a highly trained surgeon. This study aims to introduce a new technique using a condylar repositioning plate and a centric relation splint to achieve a centric relationship.MethodsWe evaluated 387 patients who had undergone surgery for skeletal jaw deformities. During the operation, a centric relation splint, intermediate splint, final centric occlusion splint, and condylar repositioning plate along with an L-type mini-plate for LeFort I osteotomy or a bicortical screw for bilateral sagittal split ramus osteotomy were utilized for rigid fixation. The evaluation included: a physical examination to detect preoperative and postoperative temporomandibular joint dysfunction, 3-dimensional computed tomography and oblique transcranial temporomandibular joint radiography to measure 3-dimensional condylar head movement, and posteroanterior and lateral cephalometric radiography to measure the preoperative and postoperative movement of the bony segment and relapse rate.ResultsA 0.3% relapse rate was observed in the coronal plane, and a 2.8% relapse rate in the sagittal plane, which is indistinguishable from the dental relapse rate in orthodontic treatment. The condylar repositioning plate could not fully prevent movement of the condylar head, but the relapse rate was minimal, implying that the movement of the condylar head was within tolerable limits.ConclusionsOur condylar repositioning method using a centric relation splint and mini-plate in orthognathic surgery was found to be simple and effective for patients suffering from skeletal jaw deformities.

Photogrammetry for Repositioning in Additive Manufacturing

DEFF Research Database (Denmark)

Jensen, Janus Nørtoft; Lyngby, Rasmus Ahrenkiel; Aanæs, Henrik

2017-01-01

In this preliminary work, we present our current status on how to use single camera photogrammetry to determine the orientation of an additively manufactured partly finished object that has been repositioned in the printing chamber, from a single image taken with a calibrated camera, and comparing...... this to the CAD model of the object. We describe how this knowledge can be used to update the machine code of the printer such that printing of the object can be resumed in the new location. This opens possibilities for embedding and assembling foreign parts into the additive manufacturing pipeline, adding...

Repositioning Ideology Critique in a Critical Theory of Adult Learning.

Science.gov (United States)

Brookfield, Stephen

2001-01-01

Reexamines critical theory as a response to Marxism and repositions ideology critique as a crucial adult learning process. Argues that a critical theory of adult learning should focus on how adults learn to recognize and challenge ideological domination and manipulation. (Contains 31 references.) (SK)

Patient repositioning in prostate conformal radiotherapy by image fusion

International Nuclear Information System (INIS)

Betrouni, Nacim

2004-01-01

This research thesis first proposes an overview of imaging modalities which are generally used in radiotherapy, and briefly presents operation principles for ultrasound scans, scanners and MRI. The issue of patient repositioning in radiotherapy is then introduced, and already proposed solutions are presented. In the next part, the author addresses space location and ultrasound-based location, with a brief overview of methods used to track the displacements of a mobile object, in this case an ultrasound probe, and calibration. Then, after a presentation of the adopted method, and a discussion of published works related to contour extraction and to filtering and noise reduction methods in ultrasound imagery, the author addresses the issue of prostate segmentation based on ultrasound images. The next part deals with image registration with an overview of available methods and tools. A method of registration of pre-operation images obtained by MRI or scanner, and of intra-operation ultrasound images is proposed for a real-time registration. This method is aimed at supporting patient repositioning during prostate conformal radiotherapy

DESIGN OF DYADIC-INTEGER-COEFFICIENTS BASED BI-ORTHOGONAL WAVELET FILTERS FOR IMAGE SUPER-RESOLUTION USING SUB-PIXEL IMAGE REGISTRATION

Directory of Open Access Journals (Sweden)

P.B. Chopade

2014-05-01

Full Text Available This paper presents image super-resolution scheme based on sub-pixel image registration by the design of a specific class of dyadic-integer-coefficient based wavelet filters derived from the construction of a half-band polynomial. First, the integer-coefficient based half-band polynomial is designed by the splitting approach. Next, this designed half-band polynomial is factorized and assigned specific number of vanishing moments and roots to obtain the dyadic-integer coefficients low-pass analysis and synthesis filters. The possibility of these dyadic-integer coefficients based wavelet filters is explored in the field of image super-resolution using sub-pixel image registration. The two-resolution frames are registered at a specific shift from one another to restore the resolution lost by CCD array of camera. The discrete wavelet transform (DWT obtained from the designed coefficients is applied on these two low-resolution images to obtain the high resolution image. The developed approach is validated by comparing the quality metrics with existing filter banks.

Nucleosome Repositioning: A Novel Mechanism for Nicotine- and Cocaine-Induced Epigenetic Changes.

Directory of Open Access Journals (Sweden)

Amber N Brown

Full Text Available Drugs of abuse modify behavior by altering gene expression in the brain. Gene expression can be regulated by changes in DNA methylation as well as by histone modifications, which alter chromatin structure, DNA compaction and DNA accessibility. In order to better understand the molecular mechanisms directing drug-induced changes in chromatin structure, we examined DNA-nucleosome interactions within promoter regions of 858 genes in human neuroblastoma cells (SH-SY5Y exposed to nicotine or cocaine. Widespread, drug- and time-resolved repositioning of nucleosomes was identified at the transcription start site and promoter region of multiple genes. Nicotine and cocaine produced unique and shared changes in terms of the numbers and types of genes affected, as well as repositioning of nucleosomes at sites which could increase or decrease the probability of gene expression based on DNA accessibility. Half of the drug-induced nucleosome positions approximated a theoretical model of nucleosome occupancy based on physical and chemical characteristics of the DNA sequence, whereas the basal or drug naïve positions were generally DNA sequence independent. Thus we suggest that nucleosome repositioning represents an initial dynamic genome-wide alteration of the transcriptional landscape preceding more selective downstream transcriptional reprogramming, which ultimately characterizes the cell- and tissue-specific responses to drugs of abuse.

Prerequisites and opportunities for repositioning of the Urals metallurgy within the Industry 4.0

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O. A. Romanova

2017-12-01

Full Text Available The authors present the modern trends in the development of metallurgy, and classify the technological structure of metallurgical industry. The article contains specific features of the development of metallurgy in the conditions of industry formation. A special role in this process plays the pace of digitalization and robotization of the industry, the development of additive technologies, Internet of things. The authors substantiate the possibility of developing the metallurgy of the Middle Urals as a science-intensive, high-tech complex that meets the requirements of Industry 4.0. This possibility interrelates with its repositioning, one of the main tasks of which is the formation of new sales markets focused on high-tech consumer industries, as well as the preservation of traditional consumption sectors under conditions of increasing competition in the construction materials market. The authors underline the importance of international cooperation in the field of environmentally safe industrial development, with applying the best available technologies and innovative development in general. The authors propose a methodological approach for assessing the repositioning of the regional metallurgical complex. This approach is the consecutive implementation of the following stages: assessment of dynamics and the forecast of development of consumer steel products sector and its structure based on identified priority areas of technological development of metallurgy in the region; construction of a factor model describing the changes in parameters of the RMC repositioning process, and approximation of the characteristics of their nonlinear elements; building a mathematical model on the basis of neural network algorithms for assessing the process of repositioning the RMC, taking into account projected values of the RMK parameters in the process of repositioning and changing the structure of consumer markets for metal products; formation of a variable

Modified Lip Repositioning with Esthetic Crown Lengthening: A Combined Approach to Treating Excessive Gingival Display.

Science.gov (United States)

Sánchez, Isis M; Gaud-Quintana, Sadja; Stern, Jacob K

Lip repositioning surgery to address excessive gingival display induced by different etiologies has received major attention recently. Several techniques and variations have been reported, including myotomy or repositioning of the levator labii superioris muscle, Le Fort impaction, maxillary gingivectomies, botulinum toxin injections, and lip stabilization. This study reports a case of excessive gingival display treated by a modified combined approach. A 25-year-old woman with a 4- to 8-mm gingival display when smiling caused by a combination of short clinical crowns induced by an altered passive eruption and hypermobility of the upper lip underwent a staged esthetic crown-lengthening procedure followed by a modified lip repositioning technique. A description of the technique and a comparison with other modes of therapy is discussed. This modified approach for treating the hypermobile lip included a bilateral removal of a partial-thickness strip of mucosa from the maxillary buccal vestibule without severing the muscle, leaving the midline frenum intact and suturing the lip mucosa to the mucogingival line. The narrower vestibule and increased tooth length resulted in a symmetric and pleasing gingival display when smiling that remained stable over time. With proper diagnosis and sequence of therapy, modified lip repositioning surgery combined with esthetic crown lengthening can be used predictably to treat excessive gingival display and enhance smile esthetics.

Place of the reposition flap in the treatment of distal amputations of the fingers.

Science.gov (United States)

Sbai, Mohamed Ali; M'chirgui, Mayssa El; Maalla, Riadh; Khorbi, Adel

2017-08-01

Distal finger amputations pose a therapeutic problem with the distal fragment quality. Reimplantation remains the reference treatment for functional and aesthetic recovery of the hand. The interest of this study is to propose the reposition flap as an alternative to different hedging techniques in the proximal stump, in many situations where revascularization is impossible. It consists in osteosynthesis of the bone fragment and its coverage by a pedicled local flap. The technique of reposition flap was evaluated retrospectively between 2003 and 2016 through a study of 13 patients compiled in Nabeul orthopedic department. For each patient, the sensitivity, the pulp trophicity, the interphalangeal mobility, the digital length, the appearance of the nail and radiological consolidation were evaluated. The reposition flap keeps more than 80% of the length of p3. This procedure improves nail aesthetics in comparison with the regularizations. There is no significant difference in sensitivity of the pulp or of the mobility of the distal inter-phalangeal (DIP) joint as a function of the technique studied. However there is a significant difference in average test of the Quick Dash (350 against 500 for regularizations). The reposition flap seems to be a good alternative to regularization in the context of trans-p3 fingers amputations, in which the distal fragment is not revascularizable. It allows better aesthetic and functional results. Copyright © 2017 Daping Hospital and the Research Institute of Surgery of the Third Military Medical University. Production and hosting by Elsevier B.V. All rights reserved.

Segmentation of arterial vessel wall motion to sub-pixel resolution using M-mode ultrasound.

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Fancourt, Craig; Azer, Karim; Ramcharan, Sharmilee L; Bunzel, Michelle; Cambell, Barry R; Sachs, Jeffrey R; Walker, Matthew

2008-01-01

We describe a method for segmenting arterial vessel wall motion to sub-pixel resolution, using the returns from M-mode ultrasound. The technique involves measuring the spatial offset between all pairs of scans from their cross-correlation, converting the spatial offsets to relative wall motion through a global optimization, and finally translating from relative to absolute wall motion by interpolation over the M-mode image. The resulting detailed wall distension waveform has the potential to enhance existing vascular biomarkers, such as strain and compliance, as well as enable new ones.

Correlation of clinical predictions and surgical results in maxillary superior repositioning.

Science.gov (United States)

Tabrizi, Reza; Zamiri, Barbad; Kazemi, Hamidreza

2014-05-01

This is a prospective study to evaluate the accuracy of clinical predictions related to surgical results in subjects who underwent maxillary superior repositioning without anterior-posterior movement. Surgeons' predictions according to clinical (tooth show at rest and at the maximum smile) and cephalometric evaluation were documented for the amount of maxillary superior repositioning. Overcorrection or undercorrection was documented for every subject 1 year after the operations. Receiver operating characteristic curve test was used to find a cutoff point in prediction errors and to determine positive predictive value (PPV) and negative predictive value. Forty subjects (14 males and 26 females) were studied. Results showed a significant difference between changes in the tooth show at rest and at the maximum smile line before and after surgery. Analysis of the data demonstrated no correlation between the predictive data and the surgical results. The incidence of undercorrection (25%) was more common than overcorrection (7.5%). The cutoff point for errors in predictions was 5 mm for tooth show at rest and 15 mm at the maximum smile. When the amount of the presurgical tooth show at rest was more than 5 mm, 50.5% of clinical predictions did not match the clinical results (PPV), and 75% of clinical predictions showed the same results when the tooth show was less than 5 mm (negative predictive value). When the amount of presurgical tooth shown in the maximum smile line was more than 15 mm, 75% of clinical predictions did not match with clinical results (PPV), and 25% of the predictions had the same results because the tooth show at the maximum smile was lower than 15 mm. Clinical predictions according to the tooth show at rest and at the maximum smile have a poor correlation with clinical results in maxillary superior repositioning for vertical maxillary excess. The risk of errors in predictions increased when the amount of superior repositioning of the maxilla increased

Home particle repositioning maneuver to prevent the recurrence of posterior canal BPPV.

Science.gov (United States)

Ismail, Elshahat Ibrahem; Morgan, Ashraf Elsayed; Abdeltawwab, Mohamed Moustafa

2018-03-08

To check the value of home particle repositioning maneuver in the prevention of the recurrence of posterior canal benign paroxysmal positional vertigo (pc-BPPV). In this study, patients diagnosed as unilateral posterior canal BPPV were selected following an accurate evaluation using video goggle VNG system. All patients were managed by particle repositioning maneuver (PRM). Patients were instructed to do home PRM once weekly for five years. Then, they were divided into two groups (according to choice of patient to do PRM). The first group (control group) consisted of 144 patients who did not do home PRM; whereas the second group (study group) included 165 patients who performed home PRM. All patients (control & study groups) were followed up every four months for five years. The study found out that the recurrence rate of pc-BPPV in control group was 33 patients in the first year (27.2%), 11 patients in second year (9%), 5 patients in third year (4%), 3 patients in fourth year (2.5%) and 3 patients in fifth year (2.5%). The recurrence of pc-BPPV in the treated side (study group) of patients was reported as 5 patients in the first year (3.5%), 3 patients in the second year (2%), 2 patients in the third year (1.4%), 2 patients in the fourth year (1.4%), and 1 patient in the fifth year (0.7%). There was statistically significant difference between the control and the study groups regarding the recurrence rates in the first year follow up which was the highest in first four months. Home particle repositioning maneuver has the capacity to prevent the recurrence of pc-BPPV. It proved to be more successful and functional in minimizing the recurrence of the disease in the study than in the control group. Hence, home particle repositioning maneuver is highly recommended for one year at least in pc-BPPV. Copyright © 2018 Elsevier B.V. All rights reserved.

Subpixel Snow Cover Mapping from MODIS Data by Nonparametric Regression Splines

Science.gov (United States)

Akyurek, Z.; Kuter, S.; Weber, G. W.

2016-12-01

Spatial extent of snow cover is often considered as one of the key parameters in climatological, hydrological and ecological modeling due to its energy storage, high reflectance in the visible and NIR regions of the electromagnetic spectrum, significant heat capacity and insulating properties. A significant challenge in snow mapping by remote sensing (RS) is the trade-off between the temporal and spatial resolution of satellite imageries. In order to tackle this issue, machine learning-based subpixel snow mapping methods, like Artificial Neural Networks (ANNs), from low or moderate resolution images have been proposed. Multivariate Adaptive Regression Splines (MARS) is a nonparametric regression tool that can build flexible models for high dimensional and complex nonlinear data. Although MARS is not often employed in RS, it has various successful implementations such as estimation of vertical total electron content in ionosphere, atmospheric correction and classification of satellite images. This study is the first attempt in RS to evaluate the applicability of MARS for subpixel snow cover mapping from MODIS data. Total 16 MODIS-Landsat ETM+ image pairs taken over European Alps between March 2000 and April 2003 were used in the study. MODIS top-of-atmospheric reflectance, NDSI, NDVI and land cover classes were used as predictor variables. Cloud-covered, cloud shadow, water and bad-quality pixels were excluded from further analysis by a spatial mask. MARS models were trained and validated by using reference fractional snow cover (FSC) maps generated from higher spatial resolution Landsat ETM+ binary snow cover maps. A multilayer feed-forward ANN with one hidden layer trained with backpropagation was also developed. The mutual comparison of obtained MARS and ANN models was accomplished on independent test areas. The MARS model performed better than the ANN model with an average RMSE of 0.1288 over the independent test areas; whereas the average RMSE of the ANN model

Improving sub-pixel imperviousness change prediction by ensembling heterogeneous non-linear regression models

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Drzewiecki Wojciech

2016-12-01

Full Text Available In this work nine non-linear regression models were compared for sub-pixel impervious surface area mapping from Landsat images. The comparison was done in three study areas both for accuracy of imperviousness coverage evaluation in individual points in time and accuracy of imperviousness change assessment. The performance of individual machine learning algorithms (Cubist, Random Forest, stochastic gradient boosting of regression trees, k-nearest neighbors regression, random k-nearest neighbors regression, Multivariate Adaptive Regression Splines, averaged neural networks, and support vector machines with polynomial and radial kernels was also compared with the performance of heterogeneous model ensembles constructed from the best models trained using particular techniques.

Drug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory.

Science.gov (United States)

Huang, Chien-Hung; Chang, Peter Mu-Hsin; Hsu, Chia-Wei; Huang, Chi-Ying F; Ng, Ka-Lok

2016-01-11

Non-small cell lung cancer (NSCLC) is one of the leading causes of death globally, and research into NSCLC has been accumulating steadily over several years. Drug repositioning is the current trend in the pharmaceutical industry for identifying potential new uses for existing drugs and accelerating the development process of drugs, as well as reducing side effects. This work integrates two approaches--machine learning algorithms and topological parameter-based classification--to develop a novel pipeline of drug repositioning to analyze four lung cancer microarray datasets, enriched biological processes, potential therapeutic drugs and targeted genes for NSCLC treatments. A total of 7 (8) and 11 (12) promising drugs (targeted genes) were discovered for treating early- and late-stage NSCLC, respectively. The effectiveness of these drugs is supported by the literature, experimentally determined in-vitro IC50 and clinical trials. This work provides better drug prediction accuracy than competitive research according to IC50 measurements. With the novel pipeline of drug repositioning, the discovery of enriched pathways and potential drugs related to NSCLC can provide insight into the key regulators of tumorigenesis and the treatment of NSCLC. Based on the verified effectiveness of the targeted drugs predicted by this pipeline, we suggest that our drug-finding pipeline is effective for repositioning drugs.

Laser-assisted lip repositioning surgery: Novel approach to treat gummy smile

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Sana Farista

2017-01-01

Full Text Available Excessive gingival display (EGD resulting in a “gummy smile” is a major esthetic concern with ramifications in an individual's personal and social life. Numerous treatment modalities have been used for the correction of EGD. The present case report describes the successful treatment of a young woman with an excess gingival display caused by a hyperactive upper lip and a mild vertical maxillary excess that was treated with a laser-assisted lip repositioning surgical technique accompanied by gingival recontouring. The procedure was accomplished by laser-assisted removal, through scraping a strip of mucosa from the maxillary buccal vestibule and suturing the mucosa of the lip to the mucogingival junction. This technique resulted in shortened vestibule and restricted the muscle pull of the elevator muscles of the lip, thereby reducing gingival display when the patient smiles. Laser-assisted lip repositioning surgery can be a viable, minimally invasive alternative to orthognathic surgery.

Flip-Floppers and Wafflers: Explanations and Repositioning

DEFF Research Database (Denmark)

Robison, Joshua

to this literature by showing that repositioning’s influence on evaluations depends on beliefs citizens make concerning why the policy switch occurred, beliefs that are, in turn, structured by the communication environment surrounding such switches. Specifically, I use two large national survey experiments to show...... that repositioning elites who provide a satisfactory explanation for their change in position escape evaluative harm from their actions and that this occurs even among individuals who lost proximity from the elite’s change in position and among those from a different party as the elite. This study thus has important...

Effects of over-the-counter jaw-repositioning mouth guards on dynamic balance, flexibility, agility, strength, and power in college-aged male athletes.

Science.gov (United States)

Golem, Devon L; Arent, Shawn M

2015-02-01

Improvements in muscular power and anaerobic performance have resulted from the use of jaw-repositioning mouth guards designed with advanced dental techniques. The high cost of such techniques has dissuaded the widespread use. Recently, more affordable, over-the-counter (OTC) jaw-repositioning mouth guards have become available. The primary objective of this study was to examine the effects of 2 OTC jaw-repositioning mouth guards on muscular power and strength performance in college-aged male athletes. It was hypothesized that similar to previous observations with advanced dentistry-designed mouth guards, OTC jaw-repositioning mouth guards would impart positive effects on muscular power but not have any effect on muscular strength. Secondary objectives of this study included the examination of the effects of 2 OTC jaw-repositioning mouth guards on other variables related to athletic performance. Male collegiate athletes (N = 20) participated in 4 separate testing sessions that consisted of assessment of muscular power, dynamic balance, flexibility, agility, and muscular strength. The 4 conditions, 1 per testing session, were assigned in a randomized order and consisted of a no-mouth guard control (CON), a placebo mouth guard, a self-adapted jaw-repositioning mouth guard (SA), and a custom-fitted jaw-repositioning mouth guard (CF). No significant differences were observed between conditions in muscular power (p = 0.78), dynamic balance (p = 0.99), agility (p = 0.22), or muscular strength (p = 0.47). The CF had significantly lower hip flexion than the CON (p = 0.014) and had significantly greater lumbar spine lateral flexion compared with the SA condition (p = 0.054). However, these flexibility differences lack practical relevance as the effect sizes remain very small (ES = -0.27 and -0.14, respectively). In conclusion, the jaw-repositioning technique used in the design of these OTC mouth guards did not affect performance. It is important to note that negative

Drug Repositioning by Kernel-Based Integration of Molecular Structure, Molecular Activity, and Phenotype Data

Science.gov (United States)

Wang, Yongcui; Chen, Shilong; Deng, Naiyang; Wang, Yong

2013-01-01

Computational inference of novel therapeutic values for existing drugs, i.e., drug repositioning, offers the great prospect for faster and low-risk drug development. Previous researches have indicated that chemical structures, target proteins, and side-effects could provide rich information in drug similarity assessment and further disease similarity. However, each single data source is important in its own way and data integration holds the great promise to reposition drug more accurately. Here, we propose a new method for drug repositioning, PreDR (Predict Drug Repositioning), to integrate molecular structure, molecular activity, and phenotype data. Specifically, we characterize drug by profiling in chemical structure, target protein, and side-effects space, and define a kernel function to correlate drugs with diseases. Then we train a support vector machine (SVM) to computationally predict novel drug-disease interactions. PreDR is validated on a well-established drug-disease network with 1,933 interactions among 593 drugs and 313 diseases. By cross-validation, we find that chemical structure, drug target, and side-effects information are all predictive for drug-disease relationships. More experimentally observed drug-disease interactions can be revealed by integrating these three data sources. Comparison with existing methods demonstrates that PreDR is competitive both in accuracy and coverage. Follow-up database search and pathway analysis indicate that our new predictions are worthy of further experimental validation. Particularly several novel predictions are supported by clinical trials databases and this shows the significant prospects of PreDR in future drug treatment. In conclusion, our new method, PreDR, can serve as a useful tool in drug discovery to efficiently identify novel drug-disease interactions. In addition, our heterogeneous data integration framework can be applied to other problems. PMID:24244318

Mining drug-disease relationships as a complement to medical genetics-based drug repositioning: Where a recommendation system meets genome-wide association studies.

Science.gov (United States)

Wang, H; Gu, Q; Wei, J; Cao, Z; Liu, Q

2015-05-01

A novel recommendation-based drug repositioning strategy is presented to simultaneously determine novel drug indications and side effects in one integrated framework. This strategy provides a complementary method to medical genetics-based drug repositioning, which reduces the occurrence of false positives in medical genetics-based drug repositioning, resulting in a ranked list of new candidate indications and/or side effects with different confidence levels. Several new drug indications and side effects are reported with high prediction confidences. © 2015 American Society for Clinical Pharmacology and Therapeutics.

Can stimulating massage improve joint repositioning error in patients with knee osteoarthritis?

DEFF Research Database (Denmark)

Lund, Hans; Henriksen, Marius; Bartels, Else M

2009-01-01

PURPOSE: The purpose of this study was to investigate the effect of massage applied to the thigh muscles on joint repositioning error (JRE) in patients suffering from osteoarthritis (OA).We hypothesized that stimulating massage of the muscles around an osteoarthritic knee joint, could improve the...

Pre and post garter spring repositioning ultrasonic inspection of pressure tubes

International Nuclear Information System (INIS)

Desimone, C.; Katchadjian, P.; Tacchia, Mauricio

1997-01-01

This paper present a description of the ultrasonic cracked hydride blister detections system used for pre and post inspection of pressure tubes during garter spring repositioning in CNE (Embalse Nuclear Power Station). Ultrasonic system setup configuration, transducers characteristics, blister detection head, calibration of parameters, operating procedure, records of ultrasonic inspections and evaluation. (author) [es

Repositório institucional como componente de sistemas de informação gerencial para universidades

Directory of Open Access Journals (Sweden)

Milton Shintaku

2015-04-01

Full Text Available As universidades são instituições de ensino que se destacam pela formação e pesquisa. Possui certa autonomia e compartilha características com outras instituições prestadoras de serviço, no que concerne a gestão de pessoal e finanças, mas com diferenças nas questões pedagógicas e de pesquisa. Nesse sentido, requer informação estratégica que apoie as decisões voltadas às questões relacionadas às peculiaridades da instituição. Nesse contexto, o presente estudo tem por objetivo analisar os repositórios institucionais acadêmicos como parte do sistema de informação para universidades, que forneça informações estratégicas a instituição. Um estudo de cunho qualitativo, de forma a relacionar conceitos de repositórios e sistemas de informação. Por conter a produção acadêmica da universidade, o repositório institucional pode ofertar aos gestores informações sobre essa produção e o acesso a produção, revelando questões de produtividade e visibilidade de forma geral ou escalonada. Expande a visão dos repositórios para além do processo de disseminação da informação, para a de geração de meta-informações. Revela-se uma ferramenta útil aos gestores das diversas esferas da universidade.

Clinical development of a failure detection-based online repositioning strategy for prostate IMRT--experiments, simulation, and dosimetry study.

Science.gov (United States)

Liu, Wu; Qian, Jianguo; Hancock, Steven L; Xing, Lei; Luxton, Gary

2010-10-01

To implement and evaluate clinic-ready adaptive imaging protocols for online patient repositioning (motion tracking) during prostate IMRT using treatment beam imaging supplemented by minimal, as-needed use of on-board kV. The authors examine the two-step decision-making strategy: (1) Use cine-MV imaging and online-updated characterization of prostate motion to detect target motion that is potentially beyond a predefined threshold and (2) use paired MV-kV 3D localization to determine overthreshold displacement and, if needed, reposition the patient. Two levels of clinical implementation were evaluated: (1) Field-by-field based motion correction for present-day linacs and (2) instantaneous repositioning for new-generation linacs with capabilities of simultaneous MV-kV imaging and remote automatic couch control during treatment delivery. Experiments were performed on a Varian Trilogy linac in clinical mode using a 4D motion phantom programed with prostate motion trajectories taken from patient data. Dosimetric impact was examined using a 2D ion chamber array. Simulations were done for 536 trajectories from 17 patients. Despite the loss of marker detection efficiency caused by the MLC leaves sometimes obscuring the field at the marker's projected position on the MV imager, the field-by-field correction halved (from 23% to 10%) the mean percentage of time that target displacement exceeded a 3 mm threshold, as compared to no intervention. This was achieved at minimal cost in additional imaging (average of one MV-kV pair per two to three treatment fractions) and with a very small number of repositionings (once every four to five fractions). Also with low kV usage (approximation 2/fraction), the instantaneous repositioning approach reduced overthreshold time by more than 75% (23% to 5%) even with severe MLC blockage as often encountered in current IMRT and could reduce the overthreshold time tenfold (to < 2%) if the MLC blockage problem were relieved. The information

Clinical development of a failure detection-based online repositioning strategy for prostate IMRT--Experiments, simulation, and dosimetry study

International Nuclear Information System (INIS)

Liu Wu; Qian Jianguo; Hancock, Steven L.; Xing, Lei; Luxton, Gary

2010-01-01

Purpose: To implement and evaluate clinic-ready adaptive imaging protocols for online patient repositioning (motion tracking) during prostate IMRT using treatment beam imaging supplemented by minimal, as-needed use of on-board kV. Methods: The authors examine the two-step decision-making strategy: (1) Use cine-MV imaging and online-updated characterization of prostate motion to detect target motion that is potentially beyond a predefined threshold and (2) use paired MV-kV 3D localization to determine overthreshold displacement and, if needed, reposition the patient. Two levels of clinical implementation were evaluated: (1) Field-by-field based motion correction for present-day linacs and (2) instantaneous repositioning for new-generation linacs with capabilities of simultaneous MV-kV imaging and remote automatic couch control during treatment delivery. Experiments were performed on a Varian Trilogy linac in clinical mode using a 4D motion phantom programed with prostate motion trajectories taken from patient data. Dosimetric impact was examined using a 2D ion chamber array. Simulations were done for 536 trajectories from 17 patients. Results: Despite the loss of marker detection efficiency caused by the MLC leaves sometimes obscuring the field at the marker's projected position on the MV imager, the field-by-field correction halved (from 23% to 10%) the mean percentage of time that target displacement exceeded a 3 mm threshold, as compared to no intervention. This was achieved at minimal cost in additional imaging (average of one MV-kV pair per two to three treatment fractions) and with a very small number of repositionings (once every four to five fractions). Also with low kV usage (∼2/fraction), the instantaneous repositioning approach reduced overthreshold time by more than 75% (23% to 5%) even with severe MLC blockage as often encountered in current IMRT and could reduce the overthreshold time tenfold (to <2%) if the MLC blockage problem were relieved. The

THE EFFECT OF NEW IDENTITY, NEW IMAGE, AND REPOSITIONING AS A PROCESS OF REBRANDING TOWARD BRAND LOYALTY, BRAND ASSOCIATIONS, PERCEIVED QUALITY AS PART OF BRAND EQUITY

Directory of Open Access Journals (Sweden)

Setiani T.

2018-04-01

Full Text Available Media companies are growing rapidly, along with technological advances, where the success of a media must be supported by brand management. This study examines corporate rebranding by changing name, logo and slogan in influencing brand equity in media companies. Not only to measure the concepts of corporate rebranding and brand equity, the study also examines the relationships between indicators that are used as variables, namely new identity with brand association, new image with brand association, new image with perceived quality, new image with brand loyalty, repositioning with brand association, repositioning with perceived quality and repositioning with brand loyalty. The method of analysis in this study using multiple linear with SPSS analysis. 110 respondents who are advertiser of Radio Kencana Malang in 2017. This study shows a significant effect between corporate rebranding to brand equity simultaneously, new identity with brand association, new image with brand association, repositioning with brand association, new identity with perceived quality, new image with perceived quality, repositioning with brand loyalty, and new identity with brand loyalty. However, there is no significant effect between repositioning with perceived quality and new image with brand loyalty on Radio Kencana Malang.

Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery.

Science.gov (United States)

Jia, Zhilong; Liu, Ying; Guan, Naiyang; Bo, Xiaochen; Luo, Zhigang; Barnes, Michael R

2016-05-27

Drug repositioning, finding new indications for existing drugs, has gained much recent attention as a potentially efficient and economical strategy for accelerating new therapies into the clinic. Although improvement in the sensitivity of computational drug repositioning methods has identified numerous credible repositioning opportunities, few have been progressed. Arguably the "black box" nature of drug action in a new indication is one of the main blocks to progression, highlighting the need for methods that inform on the broader target mechanism in the disease context. We demonstrate that the analysis of co-expressed genes may be a critical first step towards illumination of both disease pathology and mode of drug action. We achieve this using a novel framework, co-expressed gene-set enrichment analysis (cogena) for co-expression analysis of gene expression signatures and gene set enrichment analysis of co-expressed genes. The cogena framework enables simultaneous, pathway driven, disease and drug repositioning analysis. Cogena can be used to illuminate coordinated changes within disease transcriptomes and identify drugs acting mechanistically within this framework. We illustrate this using a psoriatic skin transcriptome, as an exemplar, and recover two widely used Psoriasis drugs (Methotrexate and Ciclosporin) with distinct modes of action. Cogena out-performs the results of Connectivity Map and NFFinder webservers in similar disease transcriptome analyses. Furthermore, we investigated the literature support for the other top-ranked compounds to treat psoriasis and showed how the outputs of cogena analysis can contribute new insight to support the progression of drugs into the clinic. We have made cogena freely available within Bioconductor or https://github.com/zhilongjia/cogena . In conclusion, by targeting co-expressed genes within disease transcriptomes, cogena offers novel biological insight, which can be effectively harnessed for drug discovery and

Nudging at the checkout counter - A longitudinal study of the effect of a food repositioning nudge on healthy food choice.

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Van Gestel, L C; Kroese, F M; De Ridder, D T D

2018-06-01

Objective The current study is a longitudinal conceptual replication and aimed to investigate the effect of a food repositioning nudge on healthy food choice in a kiosk. Design During eight weeks, sales data were collected. The former four weeks formed the baseline phase and the latter four weeks formed the nudge phase where healthy food products were repositioned at the checkout counter display, while unhealthy alternatives remained available elsewhere in the store. Main Outcome Measures The main variable of interest was the proportion of healthy food products (selected to be repositioned) sold per day. Also exit interviews were administered to gather individual level data about purchases, and awareness and opinions of the nudge. Results Results showed that the proportion of selected healthy food products in total food sales was higher in all four nudge weeks than in all four baseline weeks. Individual level data showed that more customers had bought a selected healthy food product in the nudge phase and that customers generally approved of the nudge. Conclusion The current study strengthened the empirical evidence base of repositioning healthy food products as an effective and well-accepted nudge.

Repositioning of malpositioned or flipped central venous catheters

Energy Technology Data Exchange (ETDEWEB)

Thalhammer, A.; Jacobi, V.; Balzer, J.; Vogl, T.J. [Institute for Diagnostic and Interventional Radiology, Central Radiology Clinic, J.W. Goethe University, Frankfurt am Main (Germany)

2002-03-01

Primary misplaced or secondary flipped implanted catheters are located mostly in the right jugular vein. We demonstrate an effective method to replace fix implanted catheters such as Ports, Grochomg or Hickman catheters. Using a femoral venous approach, replacement into the superior vena cava can easily be done with a Sidewinder 1 catheter which is hooked over the misplaced central venous approach. In all our patients the method was successful. The repositioning technique described is simple, fast and has low costs. We can keep sterile conditions and do not need to solve the catheters' fixation. (orig.)

Evaluation of the Use of Sub-Pixel Offset Tracking Techniques to Monitor Landslides in Densely Vegetated Steeply Sloped Areas

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Luyi Sun

2016-08-01

Full Text Available Sub-Pixel Offset Tracking (sPOT is applied to derive high-resolution centimetre-level landslide rates in the Three Gorges Region of China using TerraSAR-X Hi-resolution Spotlight (TSX HS space-borne SAR images. These results contrast sharply with previous use of conventional differential Interferometric Synthetic Aperture Radar (DInSAR techniques in areas with steep slopes, dense vegetation and large variability in water vapour which indicated around 12% phase coherent coverage. By contrast, sPOT is capable of measuring two dimensional deformation of large gradient over steeply sloped areas covered in dense vegetation. Previous applications of sPOT in this region relies on corner reflectors (CRs, (high coherence features to obtain reliable measurements. However, CRs are expensive and difficult to install, especially in remote areas; and other potential high coherence features comparable with CRs are very few and outside the landslide boundary. The resultant sub-pixel level deformation field can be statistically analysed to yield multi-modal maps of deformation regions. This approach is shown to have a significant impact when compared with previous offset tracking measurements of landslide deformation, as it is demonstrated that sPOT can be applied even in densely vegetated terrain without relying on high-contrast surface features or requiring any de-noising process.

Place of the reposition flap in the treatment of distal amputations of the fingers

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Mohamed Ali Sbai

2017-08-01

Conclusion: The reposition flap seems to be a good alternative to regularization in the context of trans-p3 fingers amputations, in which the distal fragment is not revascularizable. It allows better aesthetic and functional results.

[Efficacy of quick repositioning maneuver for posterior semicircular canal benign paroxysmal positional vertigo in different age groups].

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Zhang, Hao; Li, Jinrang; Guo, Pengfei; Tian, Shiyu; Li, Keliang

2015-12-01

To observe the short and long-term efficacy of quick repositioning maneuver for posterior semicircular canal benign paroxysmal positional vertigo (PC-BPPV) in different age groups. The clinical data of 113 adult patients with single PC-BPPV who underwent quick repositioning maneuver from July 2009 to February 2015 were retrospectively analyzed. The quick repositioning maneuver was to roll the patient from involved side to healthy side in the coronal plane for 180° as quickly as possible. The patients were divided into 3 groups according to different ages: young group (age group (45 ≤ age group (≥ 60 years). The short and long term outcomes of the three groups were observed. The left ear was involved in 58 cases (51.3%) and the right ear in 55 cases (48.7%). The short term improvement rates of the young, middle-age and the old groups were 92.5%, 93.6% and 92.3% respectively, and the long term improvement rate was 90.0%, 85.1% and 73.1% respectively. There was no significant difference among the three groups in short and long term outcomes (P > 0.05). The recurrence rate of the three groups was 5.0%, 6.4% and 15.4% respectively, also no significant difference (P > 0.05). The quick repositioning maneuver along the coronal plane for PC-BPPV has a definite effect for every age groups. The method is simple, rapid and easy to master, and the patients are tolerated the maneuver well without evident side effect.

Repositioning Strategy for Malaysian Companies Internationalization

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Ismi Rajiani

2013-04-01

Full Text Available The rise of the emerging-market countries offers both developing and developed countries a unique opportunity to gain the benefits of a truly international economy. Consequently, it is imper- ative to advance our knowledge of emerging-market countries MNC emergence and competitive- ness including Malaysian firms on how will they position their products strategically. Based on the framework of Porter’s Generic Strategy, this paper is composed of price/ volume segments and im- pacts on product strategy theory. The aim is to identify crucial triggering cues and focus areas for Malaysian companies and measure what role these play in different segments. This study argues that some Malaysian companies will reposition themselves strategically when internationalizing and that they will focus on other factors or triggering cues when doing so not merely adapting the prevalent price leadership strategy.

Clinical development of a failure detection-based online repositioning strategy for prostate IMRT--Experiments, simulation, and dosimetry study

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Liu Wu; Qian Jianguo; Hancock, Steven L.; Xing, Lei; Luxton, Gary [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305-5847 (United States) and Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510 (United States); Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305-5847 (United States)

2010-10-15

Purpose: To implement and evaluate clinic-ready adaptive imaging protocols for online patient repositioning (motion tracking) during prostate IMRT using treatment beam imaging supplemented by minimal, as-needed use of on-board kV. Methods: The authors examine the two-step decision-making strategy: (1) Use cine-MV imaging and online-updated characterization of prostate motion to detect target motion that is potentially beyond a predefined threshold and (2) use paired MV-kV 3D localization to determine overthreshold displacement and, if needed, reposition the patient. Two levels of clinical implementation were evaluated: (1) Field-by-field based motion correction for present-day linacs and (2) instantaneous repositioning for new-generation linacs with capabilities of simultaneous MV-kV imaging and remote automatic couch control during treatment delivery. Experiments were performed on a Varian Trilogy linac in clinical mode using a 4D motion phantom programed with prostate motion trajectories taken from patient data. Dosimetric impact was examined using a 2D ion chamber array. Simulations were done for 536 trajectories from 17 patients. Results: Despite the loss of marker detection efficiency caused by the MLC leaves sometimes obscuring the field at the marker's projected position on the MV imager, the field-by-field correction halved (from 23% to 10%) the mean percentage of time that target displacement exceeded a 3 mm threshold, as compared to no intervention. This was achieved at minimal cost in additional imaging (average of one MV-kV pair per two to three treatment fractions) and with a very small number of repositionings (once every four to five fractions). Also with low kV usage ({approx}2/fraction), the instantaneous repositioning approach reduced overthreshold time by more than 75% (23% to 5%) even with severe MLC blockage as often encountered in current IMRT and could reduce the overthreshold time tenfold (to <2%) if the MLC blockage problem were

Repositioning Your EMBA Program and Reinventing Your Brand: A Case Study Analysis

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Petit, Francis

2009-01-01

The purpose of this research is to illustrate how Fordham University, the Jesuit University of New York, repositioned its Executive MBA Program and reinvented its brand, over a ten year period. More specifically, this research will analyze the current state of the Executive MBA market and will discuss the best practices and frameworks implemented…

The Immunogenetics of Psoriasis and Implications for Drug Repositioning

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Xuan Xu

2017-12-01

Full Text Available Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease’s development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineates the immunogenetic mechanisms of psoriasis and provides useful information with regards to performing drug repositioning for the treatment of psoriasis.

Performance evaluation of eddy current transducers and associated instrumentation of integrated garter spring repositioning system

International Nuclear Information System (INIS)

Sharma, B.S.V.G.; Shyam, T.V.; Shrivastava, A.K.; Sinha, R.K.

1997-01-01

To extend the life of coolant channels of operating Indian Pressurised Heavy Water Reactors (PHWRs) of an early generation, repositioning of dislocated Garter Spring (GS) spacers is necessary. For this purpose a remotely operated system named INtegrated Garter spring REpositioning System (INGRES) has been developed. As a part of this system, eddy current transducers namely Garter Spring Detection Probe (GSDP) and Concentricity Detection Probe (CDP) along with respective signal processor units have been designed and developed. These devices detect GS spacers and eccentricity between Pressure Tube (PT) and Calandria Tube (CT) of the channel respectively. During a recent campaign of INGRES at Madras Atomic Power Station unit-2 (MAPS-2), these transducer systems have fulfilled intended design and operational objectives besides providing additional information regarding channel. These aspects are discussed. (author). 6 figs

Recommendation Techniques for Drug-Target Interaction Prediction and Drug Repositioning.

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Alaimo, Salvatore; Giugno, Rosalba; Pulvirenti, Alfredo

2016-01-01

The usage of computational methods in drug discovery is a common practice. More recently, by exploiting the wealth of biological knowledge bases, a novel approach called drug repositioning has raised. Several computational methods are available, and these try to make a high-level integration of all the knowledge in order to discover unknown mechanisms. In this chapter, we review drug-target interaction prediction methods based on a recommendation system. We also give some extensions which go beyond the bipartite network case.

Effectiveness of Otolith Repositioning Maneuvers and Vestibular Rehabilitation exercises in elderly people with Benign Paroxysmal Positional Vertigo: a systematic review

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Karyna Figueiredo Ribeiro

Full Text Available Abstract Introduction Benign Paroxysmal Positional Vertigo is highly prevalent in elderly people. This condition is related to vertigo, hearing loss, tinnitus, poor balance, gait disturbance, and an increase in risk of falls, leading to postural changes and quality of life decreasing. Objective To evaluate the outcomes obtained by clinical trials on the effectiveness of Otolith Repositioning Maneuver and Vestibular Rehabilitation exercises in the treatment of Benign Paroxysmal Positional Vertigo in elderly. Methods The literature research was performed using PubMed, Scopus, Web of Science and PEDro databases, and included randomized controlled clinical trials in English, Spanish and Portuguese, published during January 2000 to August 2016. The methodological quality of the studies was assessed by PEDro score and the outcomes analysis was done by critical revision of content. Results Six studies were fully reviewed. The average age of participants ranged between 67.2 and 74.5 years. The articles were classified from 2 to 7/10 through the PEDro score. The main outcome measures analyzed were vertigo, positional nystagmus and postural balance. Additionally, the number of maneuvers necessary for remission of the symptoms, the quality of life, and the functionality were also assessed. The majority of the clinical trials used Otolith Repositioning Maneuver (n = 5 and 3 articles performed Vestibular Rehabilitation exercises in addition to Otolith Repositioning Maneuver or pharmacotherapy. One study showed that the addition of movement restrictions after maneuver did not influence the outcomes. Conclusion There was a trend of improvement in Benign Paroxysmal Positional Vertigo symptomatology in elderly patients who underwent Otolith Repositioning Maneuver. There is sparse evidence from methodologically robust clinical trials that examined the effects of Otolith Repositioning Maneuver and Vestibular Rehabilitation exercises for treating Benign Paroxysmal

Repositioning and Leaving In Situ the Central Venous Catheter During Percutaneous Treatment of Associated Superior Vena Cava Syndrome: A Report of Eight Cases

International Nuclear Information System (INIS)

Stockx, Luc; Raat, Henricus; Donck, Jan; Wilms, Guy; Marchal, Guy

1999-01-01

Purpose: To describe a combined procedure of repositioning and leaving in situ a central venous catheter followed by immediate percutaneous treatment of associated superior vena cava syndrome (SVCS). Methods: Eight patients are presented who have central venous catheter-associated SVCS (n = 6 Hickman catheters, n = 2 Port-a-cath) caused by central vein stenosis (n = 4) or concomitant thrombosis (n = 4). With the use of a vascular snare introduced via the transcubital or transjugular approach, the tip of the central venous catheter could be engaged, and repositioned after deployment of a stent in the innominate or superior vena cava. Results: In all patients it was technically feasible to reposition the central venous catheter and treat the SVCS at the same time. In one patient flipping of the Hickman catheter in its original position provoked dislocation of the released Palmaz stent, which could be positioned in the right common iliac vein. Conclusion: Repositioning of a central venous catheter just before and after stent deployment in SVCS is technically feasible and a better alternative than preprocedural removal of the vascular access

Comparison of two repositioning devices used during radiation therapy for Hodgkin's disease

International Nuclear Information System (INIS)

Bentel, Gunilla C.; Marks, Lawrence B.; Krishnamurthy, Rupa; Prosnitz, Leonard R.

1997-01-01

Purpose: Patients irradiated for Hodgkin's disease are fixed in an immobilization cradle to improve repositioning. In the early 1990s, we changed our cradle system from a 'short' upper torso cradle to an extended near-total body cradle that also includes the lower torso and thighs. In this study, we assess the impact of the extended cradle on the reproducibility of patient repositioning during irradiation of Hodgkin's disease. Methods and Materials: A total of 782 port films of 56 patients treated immediately before and after the change-over were studied to assess positioning reproducibility. Patients treated prior to 1993 were positioned in the short cradle, while those treated 1993 and later were positioned in the extended cradle. All treatment were delivered via anterior and posterior fields and treatment areas above and below the diaphragm were considered separately and together. All treatment fields were simulated and the field shape was designed on anterior and posterior radiographs. Discrepancies in field placement between the simulation radiographs and subsequent port films were noted by a radiation oncologist and requests for position adjustment (both translational and rotational shifts) were noted. The number, magnitude, and direction of any physician-requested position adjustment on port films were retrospectively reviewed. For the purpose of scoring the frequency of field misplacements, when an adjustment was noted on two port films taken during the same treatment session (i.e., a left shift on both an anterior and a posterior port film), it was scored as only one event. A two-tailed chi-square test was used to compare the differences in requested shifts in the two patient groups. Results: The study population consisted of 56 patients (31 short and 25 extended cradle) representing 92 treatment sites. A total of 782 port films representing 450 treatment setups were analyzed (292 above and 158 below the diaphragm). When all port films above the diaphragm

Overcoming Obstacles to Drug Repositioning in Japan

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Yuhei Nishimura

2017-10-01

Full Text Available Drug repositioning (DR is the process of identifying new indications for existing drugs. DR usually focuses on drugs that have cleared phase-I safety trials but has yet to show efficacy for the intended indication. Therefore, DR can probably skip the preclinical and phase-I study, which can reduce the cost throughout drug development. However, the expensive phase-II/III trials are required to establish efficacy. The obstacles to DR include identification of new indications with a high success rate in clinical studies, obtaining funding for clinical studies, patent protection, and approval systems. To tackle these obstacles, various approaches have been applied to DR worldwide. In this perspective, we provide representative examples of DR and discuss the ongoing efforts to overcome obstacles to DR in Japan.

Device for preventing spontaneous repositioning of a control element of a nuclear reactor

International Nuclear Information System (INIS)

Maslenok, B.A.; Chegaj, A.S.; Slobin, W.G.; Mednickij, W.G.; Genkin, L.I.; Petritschenko, N.F.; Mitrofanow, B.I.

1976-01-01

The invention concerns the control element of a nuclear reactor. The vertical connecting rod is to be prevented from spontaneous repositioning if the pressurized housing which encloses the control element becomes leaky. It is proposed to provide spheres as wedging elements locking the connecting rod, but also allowing easy loosening. (UWI) [de

Does prone repositioning before posterior fixation produce greater lordosis in lateral lumbar interbody fusion (LLIF)?

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Yson, Sharon C; Sembrano, Jonathan N; Santos, Edward R G; Luna, Jeffrey T P; Polly, David W

2014-10-01

Retrospective comparative radiographic review. To determine if lateral to prone repositioning before posterior fixation confers additional operative level lordosis in lateral lumbar interbody fusion (LLIF) procedures. In a review of 56 consecutive patients who underwent LLIF, there was no statistically significant change in segmental lordosis from lateral to prone once a cage is in place. The greatest lordosis increase was observed after cage insertion. We reviewed 56 consecutive patients who underwent LLIF in the lateral position followed by posterior fixation in the prone position. Eighty-eight levels were fused. Disk space angle was measured on intraoperative C-arm images, and change in operative level segmental lordosis brought about by each of the following was determined: (1) cage insertion, (2) prone repositioning, and (3) posterior instrumentation. Paired t test was used to determine significance (α=0.05). Mean lordosis improvement brought about by cage insertion was 2.6 degrees (P=0.00005). There was a 0.1 degree mean lordosis change brought about by lateral to prone positioning (P=0.47). Mean lordosis improvement brought about by posterior fixation, including rod compression, was 1.0 degree (P=0.03). In LLIF procedures, the largest increase in operative level segmental lordosis is brought about by cage insertion. Further lordosis may be gained by placing posterior fixation, including compressive maneuvers. Prone repositioning after cage placement does not produce any incremental lordosis change. Therefore, posterior fixation may be performed in the lateral position without compromising operative level sagittal alignment.

Customerizing the clinical laboratory. Repositioning for enhanced service and a competitive advantage.

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Schuler, R S

1989-01-01

The call for excellence has never been louder, especially in the health-care industry. This call typically means increased service, i.e., faster, more accurate and, of course, friendlier service--all easier said than done, but qualities that make enhanced customer service so powerful. The excellent companies are learning that because it is so difficult to customerize, few competitors do so. Therefore, by devoting the time and effort necessary for customerization, they can move ahead of their competitors. But surpassing competitors by excellent service can be done inside of companies as well as outside. All units and departments have customers. The key to customerization inside is finding out what your customers want and behaving accordingly. The results go beyond enhanced customer satisfaction. They also include enhanced energy levels, reduced turnover, increased pride, and greater creativity for the newly customerized department. All it takes is an understanding of and dedication to customerization. Repositioning the existing department is critical to the success of any attempt to customerize. This article thoroughly describes customerization and the entire process of repositioning the clinical laboratory. One will not occur without the other.

Sub-pixel estimation of tree cover and bare surface densities using regression tree analysis

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Carlos Augusto Zangrando Toneli

2011-09-01

Full Text Available Sub-pixel analysis is capable of generating continuous fields, which represent the spatial variability of certain thematic classes. The aim of this work was to develop numerical models to represent the variability of tree cover and bare surfaces within the study area. This research was conducted in the riparian buffer within a watershed of the São Francisco River in the North of Minas Gerais, Brazil. IKONOS and Landsat TM imagery were used with the GUIDE algorithm to construct the models. The results were two index images derived with regression trees for the entire study area, one representing tree cover and the other representing bare surface. The use of non-parametric and non-linear regression tree models presented satisfactory results to characterize wetland, deciduous and savanna patterns of forest formation.

Assessment of berberine as a multi-target antimicrobial: a multi-omics study for drug discovery and repositioning.

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Karaosmanoglu, Kubra; Sayar, Nihat Alpagu; Kurnaz, Isil Aksan; Akbulut, Berna Sariyar

2014-01-01

Postgenomics drug development is undergoing major transformation in the age of multi-omics studies and drug repositioning. Rather than applications solely in personalized medicine, omics science thus additionally offers a better understanding of a broader range of drug targets and drug repositioning. Berberine is an isoquinoline alkaloid found in many medicinal plants. We report here a whole genome microarray study in tandem with proteomics techniques for mining the plethora of targets that are putatively involved in the antimicrobial activity of berberine against Escherichia coli. We found DNA replication/repair and transcription to be triggered by berberine, indicating that nucleic acids, in general, are among its targets. Our combined transcriptomics and proteomics multi-omics findings underscore that, in the presence of berberine, cell wall or cell membrane transport and motility-related functions are also specifically regulated. We further report a general decline in metabolism, as seen by repression of genes in carbohydrate and amino acid metabolism, energy production, and conversion. An involvement of multidrug efflux pumps, as well as reduced membrane permeability for developing resistance against berberine in E. coli was noted. Collectively, these findings offer original and significant leads for omics-guided drug discovery and future repositioning approaches in the postgenomics era, using berberine as a multi-omics case study.

Effect of Repositioning Maneuver Type and Postmaneuver Restrictions on Vertigo and Dizziness in Benign Positional Paroxysmal Vertigo

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Toupet, Michel; Ferrary, Evelyne; Bozorg Grayeli, Alexis

2012-01-01

Introduction. To compare the efficiency of Epley (Ep) and Sémont-Toupet (ST) repositioning maneuvers and to evaluate postmaneuver restriction effect on short-term vertigo and dizziness after repositioning maneuvers by an analog visual scale (VAS) in benign positional paroxysmal vertigo (BPPV). Material and Methods. 226 consecutive adult patients with posterior canal BPPV were included. Patients were randomized into 2 different maneuver sequence groups (n = 113): 2 ST then 1 Ep or 2 Ep then 1 ST. Each group of sequence was randomized into 2 subgroups: with or without postmaneuver restrictions. Vertigo and dizziness were assessed from days 0 to 5 by VAS. Results. There was no difference between vertigo scores between Ep and ST groups. Dizziness scores were higher in Ep group during the first 3 days but became similar to those of ST group at days 4 and 5. ST maneuvers induced liberatory signs more frequently than Ep (58% versus 42% resp., P < 0.01, Fisher's test). After repositioning maneuvers, VAS scores decreased similarly in patients with and without liberatory signs. Postmaneuver restrictions did not influence VAS scores. Conclusion. Even if ST showed a higher rate of liberatory signs than Ep in this series, VAS scores were not influenced by these signs. PMID:22973168

Use of modified lip repositioning technique associated with esthetic crown lengthening for treatment of excessive gingival display: A case report of multiple etiologies

Science.gov (United States)

Mantovani, Matheus Bortoluzzi; Souza, Eduardo Clemente; Marson, Fabiano Carlos; Corrêa, Giovani Oliveira; Progiante, Patrícia Saram; Silva, Cléverson Oliveira

2016-01-01

Excessive gingival display during smile can result in compromised esthetics. This study aims to report a case of excessive gingival display with multiple etiologies treated by means of modified lip repositioning technique associated with esthetic crown lengthening. A 23-year-old female patient, with 5-mm gingival display during smile caused by altered passive eruption and hypermobility of the upper lip, underwent the modified lip repositioning technique associated with gingivectomy followed by flap elevation and ostectomy/osteoplasty. Seven months after the second procedure, the patient had her esthetic complaint solved appearing stable in the observation period. The modified lip repositioning technique is an effective procedure employed to reduce gingival display and when associated with esthetic clinical crown lengthening, can appropriately treat cases of gummy smile. PMID:27041845

Repositórios Educacionais: estudos preliminares para a Universidade Aberta do Brasil

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Rosângela Schwarz Rodrigues

Full Text Available Esta pesquisa tem como proposta refletir sobre a criação de um modelo de estruturação e catalogação dos metadados para Repositórios Educacionais Abertos. De caráter exploratório e descritivo, a pesquisa utiliza de revisão bibliográfica e documental pertinente para a fundamentação e o tratamento analítico do corpus do trabalho. A pesquisa foi realizada em duas situações complementares: a o levantamento e a análise dos principais padrões de metadados (MARC 21, Dublin Core, LOM/IEEE e a ISO 19788-2, com o intuito de definir os principais campos descritores aplicáveis para Repositórios Educacionais Abertos; e b identificação dos campos descritores utilizados no Sistema Universidade Aberta do Brasil. Por meio da análise dos padrões de metadados e da identificação dos campos descritores utilizados foram identificados dois cenários: o primeiro, macro, caracteriza-se pela relação intra e extra-institucional de Repositórios Temáticos e Institucionais; o segundo, micro, baseado nos metadados descritores das unidades didáticas. Verifica-se a interdependência entre o cenário macro e micro, e a necessidade da utilização de mecanismos de padronização e controle. O modelo resultante da análise discute a uniformização no uso de vocabulários controlados para uso no maior número possível de campos, a criação de Conselhos Editoriais Temáticos, o estabelecimento de vínculos de dependência entre objetos de aprendizagem, disciplinas, cursos, autores e Instituições, o que torna possível a relação e identificação da origem dos objetos e permite sua contextualização.

Measurement of 3-D Vibrational Motion by Dynamic Photogrammetry Using Least-Square Image Matching for Sub-Pixel Targeting to Improve Accuracy

Science.gov (United States)

Lee, Hyoseong; Rhee, Huinam; Oh, Jae Hong; Park, Jin Ho

2016-01-01

This paper deals with an improved methodology to measure three-dimensional dynamic displacements of a structure by digital close-range photogrammetry. A series of stereo images of a vibrating structure installed with targets are taken at specified intervals by using two daily-use cameras. A new methodology is proposed to accurately trace the spatial displacement of each target in three-dimensional space. This method combines the correlation and the least-square image matching so that the sub-pixel targeting can be obtained to increase the measurement accuracy. Collinearity and space resection theory are used to determine the interior and exterior orientation parameters. To verify the proposed method, experiments have been performed to measure displacements of a cantilevered beam excited by an electrodynamic shaker, which is vibrating in a complex configuration with mixed bending and torsional motions simultaneously with multiple frequencies. The results by the present method showed good agreement with the measurement by two laser displacement sensors. The proposed methodology only requires inexpensive daily-use cameras, and can remotely detect the dynamic displacement of a structure vibrating in a complex three-dimensional defection shape up to sub-pixel accuracy. It has abundant potential applications to various fields, e.g., remote vibration monitoring of an inaccessible or dangerous facility. PMID:26978366

Accuracy of combined maxillary and mandibular repositioning and of soft tissue prediction in relation to maxillary antero-superior repositioning combined with mandibular set back A computerized cephalometric evaluation of the immediate postsurgical outcome using the TIOPS planning system

DEFF Research Database (Denmark)

Donatsky, Ole; Bjørn-Jørgensen, Jens; Hermund, Niels Ulrich

2009-01-01

surgical planning system (TIOPS). MATERIAL AND METHODS: Out of 100 prospectively and consecutively treated patients, 52 patients manifested dentofacial deformities requiring bimaxillary orthognathic surgery with maxillary antero-superior repositioning combined with mandibular set back and so were included......AIM: The purpose of the present study was to evaluate the immediate postsurgical outcome of planned and predicted hard and soft tissue positional changes in relation to maxillary antero-superior repositioning combined with mandibular set back using the computerized, cephalometric, orthognathic...... positional changes were transferred to model surgery on a three-dimensional articulator system (SAM) and finally to surgery. Five to six weeks after surgery, the actually obtained hard and soft tissue profile changes were cephalometricly assessed. RESULTS: The mean accuracy of the planned and predicted hard...

Subpixel Snow-covered Area Including Differentiated Grain Size from AVIRIS Data Over the Sierra Nevada Mountain Range

Science.gov (United States)

Hill, R.; Calvin, W. M.; Harpold, A. A.

2016-12-01

Mountain snow storage is the dominant source of water for humans and ecosystems in western North America. Consequently, the spatial distribution of snow-covered area is fundamental to both hydrological, ecological, and climate models. Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) data were collected along the entire Sierra Nevada mountain range extending from north of Lake Tahoe to south of Mt. Whitney during the 2015 and 2016 snow-covered season. The AVIRIS dataset used in this experiment consists of 224 contiguous spectral channels with wavelengths ranging 400-2500 nanometers at a 15-meter spatial pixel size. Data from the Sierras were acquired on four days: 2/24/15 during a very low snow year, 3/24/16 near maximum snow accumulation, and 5/12/16 and 5/18/16 during snow ablation and snow loss. Previous retrieval of subpixel snow-covered area in alpine regions used multiple snow endmembers due to the sensitivity of snow spectral reflectance to grain size. We will present a model that analyzes multiple endmembers of varying snow grain size, vegetation, rock, and soil in segmented regions along the Sierra Nevada to determine snow-cover spatial extent, snow sub-pixel fraction and approximate grain size or melt state. The root mean squared error will provide a spectrum-wide assessment of the mixture model's goodness-of-fit. Analysis will compare snow-covered area and snow-cover depletion in the 2016 year, and annual variation from the 2015 year. Field data were also acquired on three days concurrent with the 2016 flights in the Sagehen Experimental Forest and will support ground validation of the airborne data set.

Effectiveness of Otolith Repositioning Maneuvers and Vestibular Rehabilitation exercises in elderly people with Benign Paroxysmal Positional Vertigo: a systematic review.

Science.gov (United States)

Ribeiro, Karyna Figueiredo; Oliveira, Bruna Steffeni; Freitas, Raysa V; Ferreira, Lidiane M; Deshpande, Nandini; Guerra, Ricardo O

2017-06-29

Benign Paroxysmal Positional Vertigo is highly prevalent in elderly people. This condition is related to vertigo, hearing loss, tinnitus, poor balance, gait disturbance, and an increase in risk of falls, leading to postural changes and quality of life decreasing. To evaluate the outcomes obtained by clinical trials on the effectiveness of Otolith Repositioning Maneuver and Vestibular Rehabilitation exercises in the treatment of Benign Paroxysmal Positional Vertigo in elderly. The literature research was performed using PubMed, Scopus, Web of Science and PEDro databases, and included randomized controlled clinical trials in English, Spanish and Portuguese, published during January 2000 to August 2016. The methodological quality of the studies was assessed by PEDro score and the outcomes analysis was done by critical revision of content. Six studies were fully reviewed. The average age of participants ranged between 67.2 and 74.5 years. The articles were classified from 2 to 7/10 through the PEDro score. The main outcome measures analyzed were vertigo, positional nystagmus and postural balance. Additionally, the number of maneuvers necessary for remission of the symptoms, the quality of life, and the functionality were also assessed. The majority of the clinical trials used Otolith Repositioning Maneuver (n=5) and 3 articles performed Vestibular Rehabilitation exercises in addition to Otolith Repositioning Maneuver or pharmacotherapy. One study showed that the addition of movement restrictions after maneuver did not influence the outcomes. There was a trend of improvement in Benign Paroxysmal Positional Vertigo symptomatology in elderly patients who underwent Otolith Repositioning Maneuver. There is sparse evidence from methodologically robust clinical trials that examined the effects of Otolith Repositioning Maneuver and Vestibular Rehabilitation exercises for treating Benign Paroxysmal Positional Vertigo in the elderly. Randomized controlled clinical trials with

Repositioning the patient: patient organizations, consumerism, and autonomy in Britain during the 1960s and 1970s.

Science.gov (United States)

Mold, Alex

2013-01-01

This article explores how and why the patient came to be repositioned as a political actor within British health care during the 1960s and 1970s. Focusing on the role played by patient organizations, it is suggested that the repositioning of the patient needs to be seen in the light of growing demands for greater patient autonomy and the application of consumerist principles to health. Examining the activities of two patient groups-the National Association for the Welfare of Children in Hospital (NAWCH) and the Patients Association (PA)-indicates that while such groups undoubtedly placed more emphasis on individual autonomy, collective concerns did not entirely fall away. The voices of patients, as well as the patient, continued to matter within British health care.

Differences between novice and experienced caregivers in muscle activity and perceived exertion while repositioning bedridden patients.

Science.gov (United States)

Daikoku, Rie; Saito, Yayoi

2008-11-01

The aim of this study was to investigate the impact of caregiver knowledge and experience on muscle activity and perceived exertion while repositioning bedridden patients. Subjects were 40- to 65-year-old female caregivers divided into novice and experienced groups. Subjects from both groups performed home-care repositioning techniques on bedridden patients while muscle activity was recorded via electromyogram. Recordings were made from four muscles on the subjects' dominant side: the latissimus dorsi, the biceps brachii, the erector spinae, and the rectus femoris. The subjective burden involved in repositioning was also assessed using the rate of perceived exertion (RPE) and visual analog scales (VAS). Rectus femoris percentage of maximum voluntary contraction (%MVC) values were significantly lower than latissimus dorsi, erector spinae, and biceps brachii values in the novice group. %MVC values from the latissimus dorsi and biceps brachii were significantly higher among the novice group compared to the experienced group. RPE ratings from the novice group were significantly higher than those of the experienced group, and there was a non-significant trend for higher VAS values for the low back, arms, and legs in the novice group compared to the experienced group. Novice caregivers tended to change the patient's position by pulling with the upper limbs without using the lower limbs. In contrast, experienced caregivers exerted less energy by communicating with the patient and utilizing the patient's own movements. They used large, distributed muscle groups that effectively harnessed body mechanics and prevented excess exertion.

Drug Repositioning Discovery for Early- and Late-Stage Non-Small-Cell Lung Cancer

Directory of Open Access Journals (Sweden)

Chien-Hung Huang

2014-01-01

Full Text Available Drug repositioning is a popular approach in the pharmaceutical industry for identifying potential new uses for existing drugs and accelerating the development time. Non-small-cell lung cancer (NSCLC is one of the leading causes of death worldwide. To reduce the biological heterogeneity effects among different individuals, both normal and cancer tissues were taken from the same patient, hence allowing pairwise testing. By comparing early- and late-stage cancer patients, we can identify stage-specific NSCLC genes. Differentially expressed genes are clustered separately to form up- and downregulated communities that are used as queries to perform enrichment analysis. The results suggest that pathways for early- and late-stage cancers are different. Sets of up- and downregulated genes were submitted to the cMap web resource to identify potential drugs. To achieve high confidence drug prediction, multiple microarray experimental results were merged by performing meta-analysis. The results of a few drug findings are supported by MTT assay or clonogenic assay data. In conclusion, we have been able to assess the potential existing drugs to identify novel anticancer drugs, which may be helpful in drug repositioning discovery for NSCLC.

The Role of Elite Accounts in Mitigating the Negative Effects of Repositioning

DEFF Research Database (Denmark)

Robison, Joshua

2017-01-01

the motives of the elite when repositioning. We present evidence supportive of this argument obtained from two large experiments conducted on samples of American adults. Ultimately, we show that elites offering a satisfactory justification for their change can avoid most, if not all, of the evaluative costs...... that would otherwise occur. This study thus has important implications not just for this particular element of elite behavior, but also related questions concerning governmental accountability and representation....

Subpixelic measurement of large 1D displacements: principle, processing algorithms, performances and software.

Science.gov (United States)

Guelpa, Valérian; Laurent, Guillaume J; Sandoz, Patrick; Zea, July Galeano; Clévy, Cédric

2014-03-12

This paper presents a visual measurement method able to sense 1D rigid body displacements with very high resolutions, large ranges and high processing rates. Sub-pixelic resolution is obtained thanks to a structured pattern placed on the target. The pattern is made of twin periodic grids with slightly different periods. The periodic frames are suited for Fourier-like phase calculations-leading to high resolution-while the period difference allows the removal of phase ambiguity and thus a high range-to-resolution ratio. The paper presents the measurement principle as well as the processing algorithms (source files are provided as supplementary materials). The theoretical and experimental performances are also discussed. The processing time is around 3 µs for a line of 780 pixels, which means that the measurement rate is mostly limited by the image acquisition frame rate. A 3-σ repeatability of 5 nm is experimentally demonstrated which has to be compared with the 168 µm measurement range.

A Robust Subpixel Motion Estimation Algorithm Using HOS in the Parametric Domain

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Ibn-Elhaj E

2009-01-01

Full Text Available Motion estimation techniques are widely used in todays video processing systems. The most frequently used techniques are the optical flow method and phase correlation method. The vast majority of these algorithms consider noise-free data. Thus, in the case of the image sequences are severely corrupted by additive Gaussian (perhaps non-Gaussian noises of unknown covariance, the classical techniques will fail to work because they will also estimate the noise spatial correlation. In this paper, we have studied this topic from a viewpoint different from the above to explore the fundamental limits in image motion estimation. Our scheme is based on subpixel motion estimation algorithm using bispectrum in the parametric domain. The motion vector of a moving object is estimated by solving linear equations involving third-order hologram and the matrix containing Dirac delta function. Simulation results are presented and compared to the optical flow and phase correlation algorithms; this approach provides more reliable displacement estimates particularly for complex noisy image sequences. In our simulation, we used the database freely available on the web.

A Robust Subpixel Motion Estimation Algorithm Using HOS in the Parametric Domain

Directory of Open Access Journals (Sweden)

E. M. Ismaili Aalaoui

2009-02-01

Full Text Available Motion estimation techniques are widely used in todays video processing systems. The most frequently used techniques are the optical flow method and phase correlation method. The vast majority of these algorithms consider noise-free data. Thus, in the case of the image sequences are severely corrupted by additive Gaussian (perhaps non-Gaussian noises of unknown covariance, the classical techniques will fail to work because they will also estimate the noise spatial correlation. In this paper, we have studied this topic from a viewpoint different from the above to explore the fundamental limits in image motion estimation. Our scheme is based on subpixel motion estimation algorithm using bispectrum in the parametric domain. The motion vector of a moving object is estimated by solving linear equations involving third-order hologram and the matrix containing Dirac delta function. Simulation results are presented and compared to the optical flow and phase correlation algorithms; this approach provides more reliable displacement estimates particularly for complex noisy image sequences. In our simulation, we used the database freely available on the web.

Development and validation of a strategic repositioning model for defense and aerospace contractors

Science.gov (United States)

Bers, John A.

Strategic repositioning refers to the organized efforts of defense contractors to "reposition" a technology that they have developed for a defense sector customer into a civilian or commercial market. The strategic repositioning model developed here is a structural model: it seeks to isolate the factors that influence choice of strategy, which in turn influences the organization's performance. The model draws from the prior experience of contractors (through interviews and surveys) and companies in other sectors (through a review of the relevant published research). (1) Over all, the model accounted for 55% of the variance in financial performance of the sample and 35% for the underlying population. (2) Key success factors include a rigorous planning process, a target market in the growth (vs. incubation) stage, a priority on market leadership as well as financial return, the ability to operate in an ambiguous business environment, and a relatively short time horizon but strong corporate support. (3) The greatest challenges that a contractor is likely to encounter are understanding his new customers' buying practices, strong competition, and adapting his technology to their needs and price expectations. (4) To address these issues contractors often involve partners in their entry strategy, but partnerships of equals tend to be more difficult to bring off than direct entry strategies. (5) The two major target market categories--government and commercial--present different challenges. Commercial customers are more likely to resist doing business with the contractor, while contractors entering government and other noncommercial markets are more likely to encounter price resistance, low technical sophistication among customers, and difficulties reaching their customer base. (6) Despite these differences across markets, performance is not influenced by the target market category, nor by the type of product or service or the contractor's functional orientation (marketing

Ranked retrieval of segmented nuclei for objective assessment of cancer gene repositioning

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Cukierski William J

2012-09-01

Full Text Available Abstract Background Correct segmentation is critical to many applications within automated microscopy image analysis. Despite the availability of advanced segmentation algorithms, variations in cell morphology, sample preparation, and acquisition settings often lead to segmentation errors. This manuscript introduces a ranked-retrieval approach using logistic regression to automate selection of accurately segmented nuclei from a set of candidate segmentations. The methodology is validated on an application of spatial gene repositioning in breast cancer cell nuclei. Gene repositioning is analyzed in patient tissue sections by labeling sequences with fluorescence in situ hybridization (FISH, followed by measurement of the relative position of each gene from the nuclear center to the nuclear periphery. This technique requires hundreds of well-segmented nuclei per sample to achieve statistical significance. Although the tissue samples in this study contain a surplus of available nuclei, automatic identification of the well-segmented subset remains a challenging task. Results Logistic regression was applied to features extracted from candidate segmented nuclei, including nuclear shape, texture, context, and gene copy number, in order to rank objects according to the likelihood of being an accurately segmented nucleus. The method was demonstrated on a tissue microarray dataset of 43 breast cancer patients, comprising approximately 40,000 imaged nuclei in which the HES5 and FRA2 genes were labeled with FISH probes. Three trained reviewers independently classified nuclei into three classes of segmentation accuracy. In man vs. machine studies, the automated method outperformed the inter-observer agreement between reviewers, as measured by area under the receiver operating characteristic (ROC curve. Robustness of gene position measurements to boundary inaccuracies was demonstrated by comparing 1086 manually and automatically segmented nuclei. Pearson

Exploring Subpixel Learning Algorithms for Estimating Global Land Cover Fractions from Satellite Data Using High Performance Computing

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Uttam Kumar

2017-10-01

Full Text Available Land cover (LC refers to the physical and biological cover present over the Earth’s surface in terms of the natural environment such as vegetation, water, bare soil, etc. Most LC features occur at finer spatial scales compared to the resolution of primary remote sensing satellites. Therefore, observed data are a mixture of spectral signatures of two or more LC features resulting in mixed pixels. One solution to the mixed pixel problem is the use of subpixel learning algorithms to disintegrate the pixel spectrum into its constituent spectra. Despite the popularity and existing research conducted on the topic, the most appropriate approach is still under debate. As an attempt to address this question, we compared the performance of several subpixel learning algorithms based on least squares, sparse regression, signal–subspace and geometrical methods. Analysis of the results obtained through computer-simulated and Landsat data indicated that fully constrained least squares (FCLS outperformed the other techniques. Further, FCLS was used to unmix global Web-Enabled Landsat Data to obtain abundances of substrate (S, vegetation (V and dark object (D classes. Due to the sheer nature of data and computational needs, we leveraged the NASA Earth Exchange (NEX high-performance computing architecture to optimize and scale our algorithm for large-scale processing. Subsequently, the S-V-D abundance maps were characterized into four classes, namely forest, farmland, water and urban areas (in conjunction with nighttime lights data over California, USA using a random forest classifier. Validation of these LC maps with the National Land Cover Database 2011 products and North American Forest Dynamics static forest map shows a 6% improvement in unmixing-based classification relative to per-pixel classification. As such, abundance maps continue to offer a useful alternative to high-spatial-resolution classified maps for forest inventory analysis, multi

DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue

OpenAIRE

Wang, QuanQiu; Xu, Rong

2015-01-01

Dengue is a viral disease of expanding global incidence without cures. Here we present a drug repositioning system (DenguePredict) leveraging upon a unique drug treatment database and vast amounts of disease- and drug-related data. We first constructed a large-scale genetic disease network with enriched dengue genetics data curated from biomedical literature. We applied a network-based ranking algorithm to find dengue-related diseases from the disease network. We then developed a novel algori...

Subpixel Inundation Mapping Using Landsat-8 OLI and UAV Data for a Wetland Region on the Zoige Plateau, China

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Haoming Xia

2017-01-01

Full Text Available Wetland inundation is crucial to the survival and prosperity of fauna and flora communities in wetland ecosystems. Even small changes in surface inundation may result in a substantial impact on the wetland ecosystem characteristics and function. This study presented a novel method for wetland inundation mapping at a subpixel scale in a typical wetland region on the Zoige Plateau, northeast Tibetan Plateau, China, by combining use of an unmanned aerial vehicle (UAV and Landsat-8 Operational Land Imager (OLI data. A reference subpixel inundation percentage (SIP map at a Landsat-8 OLI 30 m pixel scale was first generated using high resolution UAV data (0.16 m. The reference SIP map and Landsat-8 OLI imagery were then used to develop SIP estimation models using three different retrieval methods (Linear spectral unmixing (LSU, Artificial neural networks (ANN, and Regression tree (RT. Based on observations from 2014, the estimation results indicated that the estimation model developed with RT method could provide the best fitting results for the mapping wetland SIP (R2 = 0.933, RMSE = 8.73% compared to the other two methods. The proposed model with RT method was validated with observations from 2013, and the estimated SIP was highly correlated with the reference SIP, with an R2 of 0.986 and an RMSE of 9.84%. This study highlighted the value of high resolution UAV data and globally and freely available Landsat data in combination with the developed approach for monitoring finely gradual inundation change patterns in wetland ecosystems.

Color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosis.

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Seung Ah Lee

Full Text Available Miniaturization of imaging systems can significantly benefit clinical diagnosis in challenging environments, where access to physicians and good equipment can be limited. Sub-pixel resolving optofluidic microscope (SROFM offers high-resolution imaging in the form of an on-chip device, with the combination of microfluidics and inexpensive CMOS image sensors. In this work, we report on the implementation of color SROFM prototypes with a demonstrated optical resolution of 0.66 µm at their highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs infected with Plasmodium falciparum, a particularly harmful type of malaria parasites and one of the major causes of death in the developing world.

3-D repositioning and differential images of volumetric CT measurements

International Nuclear Information System (INIS)

Muench, B.; Rueegsegger, P.

1993-01-01

In quantitative computed tomography (QCT), time serial measurements are performed to detect a global bone density loss or to identify localized bone density changes. A prerequisite for an unambiguous analysis is the comparison of identical bone volumes. Usually, manual repositioning is too coarse. The authors therefore developed a mathematical procedure that allows matching two three-dimensional image volumes. The algorithm is based on correlation techniques. The procedure has been optimized and applied to computer-tomographic 3-D images of the human knee. It has been tested with both artificially created and in vivo measured image data. Furthermore, typical results of differential images calculated from real bone measurements are presented

X-ray phase contrast imaging of objects with subpixel-size inhomogeneities: a geometrical optics model.

Science.gov (United States)

Gasilov, Sergei V; Coan, Paola

2012-09-01

Several x-ray phase contrast extraction algorithms use a set of images acquired along the rocking curve of a perfect flat analyzer crystal to study the internal structure of objects. By measuring the angular shift of the rocking curve peak, one can determine the local deflections of the x-ray beam propagated through a sample. Additionally, some objects determine a broadening of the crystal rocking curve, which can be explained in terms of multiple refraction of x rays by many subpixel-size inhomogeneities contained in the sample. This fact may allow us to differentiate between materials and features characterized by different refraction properties. In the present work we derive an expression for the beam broadening in the form of a linear integral of the quantity related to statistical properties of the dielectric susceptibility distribution function of the object.

COMBINING THE CONCEPTS OF BENCHMARKING AND MATRIX GAME IN MARKETING (REPOSITIONING OF SEAPORTS

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Senka Sekularac-Ivošević

2013-10-01

Full Text Available This paper considers the effects of combination of two different approaches in developing seaports positioning strategy. The first one is based on comparing the most important quantitative and qualitative seaports choice criteria by benchmarking method. Benchmarking has been used in creating the appropriate model for efficient marketing positioning of Aegean, Adriatic and Black Sea seaports. The criteria that describe the degree of these seaports competitiveness are chosen upon the investigation of ports customers’ preferences. The second employed approach based on matrix game concept has been used for the purpose of optimal repositioning of the ports. Though, nine selected ports’ functions are treated in a way that they are divided into two sets: one composed of the functions which are to be developed, and the other consisted of the functions for which it is expected to be suppressed in the future. According to the numerically obtained results the ports are repositioned, and corresponding explanations are given in the marketing manner. The mixture of these two concepts should contribute to the review of the state of these business systems and their images at the market, as well as to open prospective toward finding out the ways of creating and maintaining their competitive advantages.

An accurate bimaxillary repositioning technique using straight locking miniplates for the mandible-first approach in bimaxillary orthognathic surgery.

Science.gov (United States)

Iwai, Toshinori; Omura, Susumu; Honda, Koji; Yamashita, Yosuke; Shibutani, Naoki; Fujita, Koichi; Takasu, Hikaru; Murata, Shogo; Tohnai, Iwai

2017-01-01

Bimaxillary orthognathic surgery has been widely performed to achieve optimal functional and esthetic outcomes in patients with dentofacial deformity. Although Le Fort I osteotomy is generally performed before bilateral sagittal split osteotomy (BSSO) in the surgery, in several situations BSSO should be performed first. However, it is very difficult during bimaxillary orthognathic surgery to maintain an accurate centric relation of the condyle and decide the ideal vertical dimension from the skull base to the mandible. We have previously applied a straight locking miniplate (SLM) technique that permits accurate superior maxillary repositioning without the need for intraoperative measurements in bimaxillary orthognathic surgery. Here we describe the application of this technique for accurate bimaxillary repositioning in a mandible-first approach where the SLMs also serve as a condylar positioning device in bimaxillary orthognathic surgery.

Subpixel edge localization with reduced uncertainty by violating the Nyquist criterion

Science.gov (United States)

Heidingsfelder, Philipp; Gao, Jun; Wang, Kun; Ott, Peter

2014-12-01

In this contribution, the extent to which the Nyquist criterion can be violated in optical imaging systems with a digital sensor, e.g., a digital microscope, is investigated. In detail, we analyze the subpixel uncertainty of the detected position of a step edge, the edge of a stripe with a varying width, and that of a periodic rectangular pattern for varying pixel pitches of the sensor, thus also in aliased conditions. The analysis includes the investigation of different algorithms of edge localization based on direct fitting or based on the derivative of the edge profile, such as the common centroid method. In addition to the systematic error of these algorithms, the influence of the photon noise (PN) is included in the investigation. A simplified closed form solution for the uncertainty of the edge position caused by the PN is derived. The presented results show that, in the vast majority of cases, the pixel pitch can exceed the Nyquist sampling distance by about 50% without an increase of the uncertainty of edge localization. This allows one to increase the field-of-view without increasing the resolution of the sensor and to decrease the size of the setup by reducing the magnification. Experimental results confirm the simulation results.

Repositioning Technical and Vocational Education and Training (TVET) for Youths Employment and National Security in Nigeria

Science.gov (United States)

Ogbunaya, T. C.; Udoudo, Ekereobong S.

2015-01-01

The paper focused on repositioning Technical and Vocational Education and Training (TVET) for youth's employment and national security in Nigeria. It examined briefly the concepts of technical vocational education and training (TVET), youths, unemployment and national security as well as the effects of unemployment on national security in Nigeria.…

Trunk repositioning errors are increased in balance-impaired older adults.

Science.gov (United States)

Goldberg, Allon; Hernandez, Manuel Enrique; Alexander, Neil B

2005-10-01

Controlling the flexing trunk is critical in recovering from a loss of balance and avoiding a fall. To investigate the relationship between trunk control and balance in older adults, we measured trunk repositioning accuracy in young and balance-impaired and unimpaired older adults. Young adults (N = 8, mean age 24.3 years) and two groups of community-dwelling older adults defined by unipedal stance time (UST)-a balance-unimpaired group (UST > 30 seconds, N = 7, mean age 73.9 years) and a balance-impaired group (UST tested in standing trunk control ability by reproducing a approximately 30 degrees trunk flexion angle under three visual-surface conditions: eyes opened and closed on the floor, and eyes opened on foam. Errors in reproducing the angle were defined as trunk repositioning errors (TREs). Clinical measures related to balance, trunk extensor strength, and self-reported disability were obtained. TREs were significantly greater in the balance-impaired group than in the other groups, even when controlling for trunk extensor strength and body mass. In older adults, there were significant correlations between TREs and three clinical measures of balance and fall risk, UST and maximum step length (-0.65 to -0.75), and Timed Up & Go score (0.55), and between TREs and age (0.63-0.76). In each group TREs were similar under the three visual-surface conditions. Test-retest reliability for TREs was good to excellent (intraclass correlation coefficients > or =0.74). Older balance-impaired adults have larger TREs, and thus poorer trunk control, than do balance-unimpaired older individuals. TREs are reliable and valid measures of underlying balance impairment in older adults, and may eventually prove to be useful in predicting the ability to recover from losses of balance and to avoid falls.

A case of WAGR syndrome in association with developmental glaucoma requiring bilateral Baerveldt glaucoma implants and subsequent tube repositioning

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Akagi T

2015-06-01

Full Text Available Tadamichi Akagi, Munemitsu Yoshikawa, Hideo Nakanishi, Nagahisa Yoshimura Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan Abstract: Glaucoma drainage device implantation is efficacious for the treatment of pediatric glaucoma patients when multiple angle surgeries fail. However, tube touching of the corneal endothelium is one of the major postoperative complications to deal with. A 15-month-old male patient with Wilms’ tumor, aniridia, genitourinary anomalies, and mental retardation (WAGR syndrome was diagnosed with bilateral developmental glaucoma. He underwent Baerveldt glaucoma implant (BGI surgeries in both eyes after multiple failed trabeculotomies. The tube in his right eye was touching the cornea 15 months after BGI surgery. To avoid corneal endothelium damage, BGI tube repositioning with scleral fixation was performed without serious complications. The bilateral BGI surgeries achieved successful intraocular pressure reduction for over 2 years and tube repositioning with scleral fixation of BGI tube was successful for BGI tube malposition. Although careful attention to intraocular pressure and tube malposition is essential after glaucoma drainage device implantation, especially in pediatric cases, BGI surgery is effective in the management of developmental glaucoma following unsuccessful angle surgeries. Keywords: Baerveldt glaucoma implant, developmental glaucoma, WAGR syndrome, tube repositioning, glaucoma drainage device

Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions

OpenAIRE

Vazquez-Martin, Alejandro; López-Bonetc, Eugeni; Cufí, Sílvia; Oliveras-Ferraros, Cristina; Del Barco, Sonia; Martin-Castillo, Begoña; Menendez, Javier A.

2011-01-01

Ideal oncology drugs would be curative after a short treatment course if they could eliminate epithelium-originated carcinomas at their non-invasive, pre-malignant stages. Such ideal molecules, which are expected to molecularly abrogate all the instrumental mechanisms acquired by migrating cancer stem cells (CSCs) to by-pass tumour suppressor barriers, might already exist. We here illustrate how system biology strategies for repositioning existing FDA-approved drugs may accelerate our therape...

Te Kotahitanga: A Case Study of a Repositioning Approach to Teacher Professional Development for Culturally Responsive Pedagogies

Science.gov (United States)

Hynds, Anne; Sleeter, Christine; Hindle, Rawiri; Savage, Catherine; Penetito, Wally; Meyer, Luanna H.

2011-01-01

This article presents a case study of a unique New Zealand professional development programme, Te Kotahitanga, for mainstream secondary school teachers. Findings discussed are drawn from an independent evaluation of the programme across 22 secondary schools. The professional development approach attempted to reposition the relationship between…

Sub-Pixel Accuracy Crack Width Determination on Concrete Beams in Load Tests by Triangle Mesh Geometry Analysis

Science.gov (United States)

Liebold, F.; Maas, H.-G.

2018-05-01

This paper deals with the determination of crack widths of concrete beams during load tests from monocular image sequences. The procedure starts in a reference image of the probe with suitable surface texture under zero load, where a large number of points is defined by an interest operator. Then a triangulated irregular network is established to connect the points. Image sequences are recorded during load tests with the load increasing continuously or stepwise, or at intermittently changing load. The vertices of the triangles are tracked through the consecutive images of the sequence with sub-pixel accuracy by least squares matching. All triangles are then analyzed for changes by principal strain calculation. For each triangle showing significant strain, a crack width is computed by a thorough geometric analysis of the relative movement of the vertices.

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.

Science.gov (United States)

Astolfi, Andrea; Felicetti, Tommaso; Iraci, Nunzio; Manfroni, Giuseppe; Massari, Serena; Pietrella, Donatella; Tabarrini, Oriana; Kaatz, Glenn W; Barreca, Maria L; Sabatini, Stefano; Cecchetti, Violetta

2017-02-23

An intriguing opportunity to address antimicrobial resistance is represented by the inhibition of efflux pumps. Focusing on NorA, the most important efflux pump of Staphylococcus aureus, an efflux pump inhibitors (EPIs) library was used for ligand-based pharmacophore modeling studies. By exploitation of the obtained models, an in silico drug repositioning approach allowed for the identification of novel and potent NorA EPIs.

New customized patient repositioning system for use in three dimensional (3D) treatment planning and radiotherapy

International Nuclear Information System (INIS)

Kitahara, Toshihiro; Shirato, Hiroki; Nishioka, Takeshi; Nishiyama, Noriaki; Yamaguchi, Megumi; Watanabe, Yoshiharu; Takekawa, Naomitu; Miyasaka, Kazuo

1997-01-01

Purpose/Objective: To develop a safe and easy method for customized patient repositioning and immobilization prior to 3-D treatment planning and during precise radiotherapy. Materials and methods: The new material consists of impression material, and covering material to fix and hold the impression. The impression material is composed of numerous effervescent polystyrene beads (3.1 mm in diameter) coated by polymerizing substance, urethane prepolymer. When being wet, the material beads adhere to each other due to polymelization, and it is hardened in 5 to 10 minutes. Within one hour the mold is sufficiently dry to be used for treatment planning utilizing computed tomography(CT). The physical characteristics of the material, the subjective comfort of the patient, the reduction in time required for repositioning in the treatment of the head and neck tumors, and the reduction in patient movement in the treatment of the breast cancers were investigated. Results: During the hardening stage, the maximum temperature of the material was 33 deg. C. Non-toxic CO 2 gas was produced and evaporated from the covering fabric. The mold, with a density of 0.095, was strong enough to endure compression, flexure, and scratching. In the healthy volunteers, no sensitivity to the skin was observed after 12 hours' attachment to the skin. The CT number of the material was less than minus 800, and no build-up effect was demonstrated in megavoltage photon therapy. Various molds were made and used as neck rest adjunctive to thermoplastic face mask, whole body cast, and arm rest (Figure). A questionnaire survey administered to 59 patients with brain, head and neck tumors, and to 18 patients with breast cancers, revealed that subjective comfort was markedly improved (90.9%) of improved (9.1%) by virtue of the new material. In the treatment of head and neck tumors, the mean time and SD for repositioning were 61.1 ± 13.6 seconds with the ready-made neck-rest and 49.4 ± 8.4 seconds with the

Big Data Mining and Adverse Event Pattern Analysis in Clinical Drug Trials.

Science.gov (United States)

Federer, Callie; Yoo, Minjae; Tan, Aik Choon

2016-12-01

Drug adverse events (AEs) are a major health threat to patients seeking medical treatment and a significant barrier in drug discovery and development. AEs are now required to be submitted during clinical trials and can be extracted from ClinicalTrials.gov ( https://clinicaltrials.gov/ ), a database of clinical studies around the world. By extracting drug and AE information from ClinicalTrials.gov and structuring it into a database, drug-AEs could be established for future drug development and repositioning. To our knowledge, current AE databases contain mainly U.S. Food and Drug Administration (FDA)-approved drugs. However, our database contains both FDA-approved and experimental compounds extracted from ClinicalTrials.gov . Our database contains 8,161 clinical trials of 3,102,675 patients and 713,103 reported AEs. We extracted the information from ClinicalTrials.gov using a set of python scripts, and then used regular expressions and a drug dictionary to process and structure relevant information into a relational database. We performed data mining and pattern analysis of drug-AEs in our database. Our database can serve as a tool to assist researchers to discover drug-AE relationships for developing, repositioning, and repurposing drugs.

Repositioning of Barcelona’s Image in the Light of a Redefinition of the Urban Tourism Planning Model

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Josep-Francesc Valls

2013-01-01

Full Text Available Barcelona’s city tourism model over the last fifteen years has chalked up many successes in terms of soaring tourist numbers, overnight stays, cruise liner passengers, hotel beds and visits to priced sights. Growth in city breaks has soared to the point where Barcelona has become one of Europe’s most visited cities. But this growth has come at a heavy price: mass tourism, concentration in certain neighbourhoods, competition for space between tourists and residents, lack of adequate inter-modal transport. All of these problems threaten Barcelona’s competitive position. The paper reviews the city’s competitiveness, comparing Barcelona to ten other European cities. Starting out from a qualitative analysis of internal players and a Delphi Study with external players, we find thecity’s tourism model needs correcting. We also identify the vectors and most important factors for achieving this repositioning. The vectors reinforce the competitiveness concerning the model’s sustainability, integrated management and governance, and client orientation. The proposed strategic repositioning will allow Barcelona to continue competing with Europe’s main cities.

Federações de repositórios: conceitos, políticas, características e tendências

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Milton Shintaku

Full Text Available O surgimento das federações de repositórios, há mais de dez anos, tem apoiado a disseminação da literatura científica em acesso aberto. Entretanto, há pouca informação acadêmica sobre essas ferramentas. Nesse sentido, o presente estudo tem por objetivo apresentar informações sobre as federações, de forma a contribuir com esse tema, que ainda pouco explorado. Um estudo qualitativo, utilizando técnicas de pesquisa documental, para a verificação dos conceitos, políticas, características e tendências das federações disponíveis na internet. Os resultados revelaram consenso em vários aspectos, com um cenários colaborativo e pouco estudado, embora seja de interesse acadêmico, em que as federações fomentam a criação de repositórios. Com isso, o estudo contribui com informações sobre as federações, apresentando um tema atual.

Repositioning Skill Acquisition For The Transformation Of Nigerian Economy

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Dr. Peter Ashlame Agu

2015-08-01

Full Text Available Since the past two decades or so the question of functionality of Nigerian educational products has been an issue of concern and a subject of discussion among educational analysts. This is against the backdrop that many students who graduate with admirable certificates from the nations reputable institutions are often unable to apply the acquired knowledge and skills to work situations. Contemporary societies all over the world require that preparation for work must become an integral part of a persons total educational experience. One reason for this requirement is to equip their citizenry with employable skills to enable them produce and use the goods and services which any society needs for its socio-economic growth. This paper therefore examines the role of skill acquisition in the transformation of Nigerian economy and proffers suggestions on how it can be repositioned to transform Nigerian education.

Lip repositioning surgery: A pioneering technique for perio-esthetics

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Harpreet Singh Grover

2014-01-01

Full Text Available In our esthetic conscious society people are now demanding all types of treatments possible to have a pleasing and attractive personality. A dazzling and beautiful smile can work wonders for anyone′s personality. Our smile mirrors our persona, our unique being. However, a beautiful smile comprises of a perfect balance of the white and pink. This imbalance of excessive gingival display (EGD can be managed by a variety of treatment modalities, depending on accurate diagnosis. This case report demonstrates the successful management of EGD with a lip-repositioning procedure in a patient with incompetent short upper lip. This was accomplished by removing a partial thickness strip of mucosa from the maxillary buccal vestibule and suturing the lip mucosa to the mucogingival line. This resulted in a narrower vestibule and restricted muscle pull, thereby resulting in competent lips and reduced gingival display during smiling.

A study of the long-term effect of malar fat repositioning in face lift surgery: short-term success but long-term failure.

Science.gov (United States)

Hamra, Sam T

2002-09-01

In 1990, the author reported on a series of 403 cases of deep plane face lifts, the first published technique describing the repositioning of the cheek fat, known as malar fat, in face lift surgery. This study examines the long-term results of 20 of the original series in an attempt to determine what areas of the rejuvenated face (specifically, the malar fat) showed long-term improvement. The results were judged by comparing the preoperative and long-term postoperative views in a half-and-half same-side hemiface photograph. The anatomy of the jawline (superficial musculoaponeurotic system [SMAS]), the nasolabial fold (malar fat), and the periorbital diameter were evaluated. The results confirmed that repositioning of the SMAS remained for longer than improvement in the nasolabial fold and that the vertical diameter of the periorbit did not change at all. The early results of malar fat repositioning shown at 1 to 2 years were successful, but the long-term results showed failure of the early improvement, manifested by recurrence of the nasolabial folds. There was, however, continuation of the improved results of the forehead lift and SMAS maneuvers of the original procedure. The conclusion is that only a direct excision will produce a permanent correction of the aging nasolabial fold.

A new method of surgical navigation for orthognathic surgery: optical tracking guided free-hand repositioning of the maxillomandibular complex.

Science.gov (United States)

Li, Biao; Zhang, Lei; Sun, Hao; Shen, Steve G F; Wang, Xudong

2014-03-01

In bimaxillary orthognathic surgery, the positioning of the maxilla and the mandible is typically accomplished via 2-splint technique, which may be the sources of several types of inaccuracy. To overcome the limitations of the 2-splint technique, we developed a new navigation method, which guided the surgeon to free-hand reposition the maxillomandibular complex as a whole intraoperatively, without the intermediate splint. In this preliminary study, the feasibility was demonstrated. Five patients with dental maxillofacial deformities were enrolled. Before the surgery, 3-dimensional planning was conducted and imported into a navigation system. During the operation, a tracker was connected to the osteotomized maxillomandibular complex via a splint. The navigation system tracked the movement of the complex and displayed it on the screen in real time to guide the surgeon to reposition the complex. The postoperative result was compared with the plan by analyzing the measured distances between the maxillary landmarks and reference planes, as determined from computed tomography data. The mean absolute errors of the maxillary position were clinically acceptable (<1.0 mm). Preoperative preparation time was reduced to 100 minutes on average. All patients were satisfied with the aesthetic results. This navigation method without intraoperative image registration provided a feasible means of transferring virtual planning to the real orthognathic surgery. The real-time position of the maxillomandibular complex was displayed on a monitor to visually guide the surgeon to reposition the complex. In this method, the traditional model surgery and the intermediate splint were discarded, and the preoperative preparation was simplified.

A Novel Sub-pixel Measurement Algorithm Based on Mixed the Fractal and Digital Speckle Correlation in Frequency Domain

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Zhangfang Hu

2014-10-01

Full Text Available The digital speckle correlation is a non-contact in-plane displacement measurement method based on machine vision. Motivated by the facts that the low accuracy and large amount of calculation produced by the traditional digital speckle correlation method in spatial domain, we introduce a sub-pixel displacement measurement algorithm which employs a fast interpolation method based on fractal theory and digital speckle correlation in frequency domain. This algorithm can overcome either the blocking effect or the blurring caused by the traditional interpolation methods, and the frequency domain processing also avoids the repeated searching in the correlation recognition of the spatial domain, thus the operation quantity is largely reduced and the information extracting speed is improved. The comparative experiment is given to verify that the proposed algorithm in this paper is effective.

Serial repositioning of a Guenther tulip retrievable inferior vena cava filter in a pediatric patient

International Nuclear Information System (INIS)

Haider, Ehsan A.; Rosen, J. Choi; Torres, Carlos; Valenti, David A.

2005-01-01

We report an 11-year-old boy who required inferior vena cava (IVC) filtration for a prolonged period of time. A retrievable IVC filter was placed and repositioned three times, providing a total of 60 days of IVC filtration. The filter was removed when his risk of pulmonary embolus had decreased substantially. This is a relatively uncommon practice in the pediatric population. The technique is presented, and the available literature is reviewed. (orig.)

A BAND SELECTION METHOD FOR SUB-PIXEL TARGET DETECTION IN HYPERSPECTRAL IMAGES BASED ON LABORATORY AND FIELD REFLECTANCE SPECTRAL COMPARISON

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S. Sharifi hashjin

2016-06-01

Full Text Available In recent years, developing target detection algorithms has received growing interest in hyperspectral images. In comparison to the classification field, few studies have been done on dimension reduction or band selection for target detection in hyperspectral images. This study presents a simple method to remove bad bands from the images in a supervised manner for sub-pixel target detection. The proposed method is based on comparing field and laboratory spectra of the target of interest for detecting bad bands. For evaluation, the target detection blind test dataset is used in this study. Experimental results show that the proposed method can improve efficiency of the two well-known target detection methods, ACE and CEM.

Biomechanical reposition techniques in anterior shoulder dislocation: a randomised multicentre clinical trial- the BRASD-trial protocol.

Science.gov (United States)

Baden, David N; Roetman, Martijn H; Boeije, Tom; Roodheuvel, Floris; Mullaart-Jansen, Nieke; Peeters, Suzanne; Burg, Mike D

2017-07-20

Glenohumeral (shoulder) dislocations are the most common large joint dislocations seen in the emergency department (ED). They cause pain, often severe, and require timely interventions to minimise discomfort and tissue damage. Commonly used reposition or relocation techniques often involve traction and/or leverage. These techniques have high success rates but may be painful and time consuming. They may also cause complications. Recently, other techniques-the biomechanical reposition techniques (BRTs)-have become more popular since they may cause less pain, require less time and cause fewer complications. To our knowledge, no research exists comparing the various BRTs. Our objective is to establish which BRT or BRT combination is fastest, least painful and associated with the lowest complication rate for adult ED patients with anterior glenohumeral dislocations (AGDs). Adults presenting to the participating EDs with isolated AGDs, as determined by radiographs, will be randomised to one of three BRTs: Cunningham, modified Milch or scapular manipulation. Main study parameters/endpoints are ED length of stay and patients' self-report of pain. Secondary study parameters/endpoints are procedure times, need for analgesic and/or sedative medications, iatrogenic complications and rates of successful reduction. Non-biomechanical AGD repositioning techniques based on traction and/or leverage are inherently painful and potentially harmful. We believe that the three BRTs used in this study are more physiological, more patient friendly, less likely to cause pain, more time efficient and less likely to produce complications. By comparing these three techniques, we hope to improve the care provided to adults with acute AGDs by reducing their ED length of stay and minimising pain and procedure-related complications. We also hope to define which of the three BRTs is quickest, most likely to be successful and least likely to require sedative or analgesic medications to achieve

Fractionated stereotactic irradiation by Cyberknife of choroid melanomas: repositioning validation, closed eyelids; Irradiation stereotaxique fractionnee par Cyberknife des melanomes choroidiens: validation du repositionnement, paupieres fermees

Energy Technology Data Exchange (ETDEWEB)

Horn, S.; Rezvoy, N.; Lacornerie, T.; Mirabel, X.; Labalette, P.; Lartigau, E. [Centre Oscar-Lambret, Service de Radiotherapie, 59 - Lille (France)

2009-10-15

The fractionated stereotactic radiotherapy by Cyberknife is an option in the treatment of eyes tumors. The advantages of the Cyberknife in the choroid melanomas are in its infra-millimetric precision, to the automated repositioning on the skull bones and to the conformity brought by the stereotaxy. The objective of this study was to validate the quality of repositioning and the immobility of the eyes with closed eyelids. Conclusion: the reproducibility of the eye positioning with closed eyelids seems enough to consider the conservative treatment of choroid melanomas by fractionated stereotactic radiotherapy by Cyberknife without implementation of fiducials nor retrobulbar anaesthesia. (N.C.)

Representação iterativa e folksonomia assistida para repositórios digitais | Iterative representation and folksonomy assisted for digital repositories

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José Eduardo Santarém Segundo

2011-03-01

Full Text Available Resumo A recuperação da informação tem sido muito discutida dentro da Ciência da Informação ultimamente. A busca por informação de qualidade e compatível com a necessidade do usuário tornou-se objeto constante de pesquisa. A utilização da Internet como fonte de disseminação do conhecimento indicou novos modelos de armazenamento de informações, como os repositórios digitais, que têm sido utilizados em ambientes acadêmicos e de pesquisa como principal forma de autoarquivar e disseminar informação, porém com uma estrutura de informação que comporta melhor descrição dos recursos e consequentemente uma melhor recuperação da informação. Desta forma o objetivo deste trabalho é melhorar o processo de recuperação da informação, apresentando uma proposta de modelo estrutural no contexto da web semântica, abordando o uso de recursos da web 2.0 e web 3.0 em repositórios digitais, que permita recuperação semântica da informação, por meio da construção de uma camada de informação chamada Representação Iterativa. O presente estudo caracteriza-se como uma pesquisa descritiva e analítica, com base em análise documental, dividida em duas partes: a primeira, caracterizada pela observação direta não participativa de ferramentas que implementam repositórios digitais, assim como de repositórios digitais já instanciados, e a segunda, com característica exploratória, em que sugere um modelo inovador para repositórios, com a utilização de estruturas de representação do conhecimento e participação do usuário na construção de um vocabulário próprio de domínio. Através do modelo sugerido e proposto ─ Representação Iterativa ─ será possível adequar os repositórios digitais para que utilizem Folksonomia e também vocabulário controlado de domínio, de forma a gerar uma camada de informação iterativa, que possibilite retroalimentação da informação, além de recuperação semântica da

Repositórios institucionais como ferramentas de gestão do conhecimento científico no ambiente acadêmico

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Fernando César Lima Leite

Full Text Available Tradicionalmente, as universidades têm sido reconhecidas como espaços de produção e transferência de conhecimento científico. Embora seja possível encontrar na literatura especializada estudos sobre gestão do conhecimento no âmbito de universidades, esses estudos, via de regra, lidam com o conhecimento científico na mesma perspectiva do conhecimento organizacional. Entretanto, a natureza do conhecimento científico é peculiar, bem como o ambiente no qual se dá sua criação, seu compartilhamento e uso. Neste sentido, os repositórios institucionais surgem como alternativa tanto para a agilização do processo de comunicação científica quanto para a gestão do conhecimento científico - GCC. Discute-se, neste trabalho, a adequação e aplicabilidade dos repositórios institucionais como ferramenta de GCC.

Target and peripheral dose from radiation sector motions accompanying couch repositioning of patient coordinates with the Gamma Knife® Perfexion™

International Nuclear Information System (INIS)

Tran, Tuan-Anh; Wu, Vincent; Malhotra, Harish; Steinman, James P.; Prasad, Dheerendra; Podgorsak, Matthew B.

2011-01-01

The GammaPlan ™ treatment planning system (TPS) does not fully account for shutter dose when multiple shots are required to deliver a patient’s treatment. The unaccounted exposures to the target site and its periphery are measured in this study. The collected data are compared to a similar effect from the Gamma Knife ® model 4C. A stereotactic head frame was attached to a Leksell ® 16 cm diameter spherical phantom; using a fiducial-box, CT images of the phantom were acquired and registered in the TPS. Measurements give the relationship of measured dose to the number of repositions with the patient positioning system (PPS) and to the collimator size. An absorbed dose of 10 Gy to the 50% isodose line was prescribed to the target site and all measurements were acquired with an ionization chamber. Measured dose increases with frequency of repositioning and with collimator size. As the radiation sectors transition between the beam on and beam off states, the target receives more shutter dose than the periphery. Shutter doses of 3.53±0.04 and 1.59±0.04 cGy/reposition to the target site are observed for the 16 and 8 mm collimators, respectively. The target periphery receives additional dose that varies depending on its position relative to the target. The radiation sector motions for the Gamma Knife ® Perfexion ™ result in an additional dose due to the shutter effect. The magnitude of this exposure is comparable to that measured for the model 4C

Dramatic repositioning of c-Myb to different promoters during the cell cycle observed by combining cell sorting with chromatin immunoprecipitation.

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Anita M Quintana

2011-02-01

Full Text Available The c-Myb transcription factor is a critical regulator of proliferation and stem cell differentiation, and mutated alleles of c-Myb are oncogenic, but little is known about changes in c-Myb activity during the cell cycle. To map the association of c-Myb with specific target genes during the cell cycle, we developed a novel Fix-Sort-ChIP approach, in which asynchronously growing cells were fixed with formaldehyde, stained with Hoechst 33342 and separated into different cell cycle fractions by flow sorting, then processed for chromatin immunoprecipitation (ChIP assays. We found that c-Myb actively repositions, binding to some genes only in specific cell cycle phases. In addition, the specificity of c-Myb is dramatically different in small subpopulations of cells, for example cells in the G2/M phase of the cell cycle, than in the bulk population. The repositioning of c-Myb during the cell cycle is not due to changes in its expression and also occurs with ectopically expressed, epitope-tagged versions of c-Myb. The repositioning occurs in established cell lines, in primary human CD34+ hematopoietic progenitors and in primary human acute myeloid leukemia cells. The combination of fixation, sorting and ChIP analysis sheds new light on the dynamic nature of gene regulation during the cell cycle and provides a new type of tool for the analysis of gene regulation in small subsets of cells, such as cells in a specific phase of the cell cycle.

One-step transversal palatal distraction and maxillary repositioning: technical considerations, advantages, and long-term stability.

Science.gov (United States)

Cortese, Antonio; Savastano, Mauro; Savastano, Germano; Claudio, Pier Paolo

2011-09-01

Transversal maxillary hypoplasia in adolescence is a frequently seen pathology, which can be treated with a combination of surgery and orthodontic treatment to widen the maxilla in skeletally matured patients.We evaluated the advantages of a new surgical technique: Le Fort I distraction osteogenesis using a bone-borne device. Because relapse is one of the main problems in surgical maxillary expansion, long-term stability of this new technique was evaluated. Data from 4 adult patients with maxillary restriction, class III malocclusion, or maxillary malposition were collected preoperatively, 4 months after distraction, and 5 years after distraction. Measurements were recorded on dental models to detect palatal expansion at dental level; cephalograms by lateral and posteroanterior plane were analyzed to detect maxillary movements. Maxillary measurements were substantially stable 5 years after distractions. Only minor dental movements occurred at the dental analysis after 5 years related to a lack of orthodontic contention without any compromise of the dental result (no crossbite relapse and class I stability). Le Fort I with down-fracture for expansion and repositioning by bone-borne distractor device can [corrected] be used to simultaneously widen, advance, and vertically reposition the maxilla without causing healing problems, particularly using a rigid distraction device. Long-term stability can be achieved; however, further studies with a larger number of patients will be necessary for better evaluation.

Repositioning accuracy of two different mask systems-3D revisited: Comparison using true 3D/3D matching with cone-beam CT

International Nuclear Information System (INIS)

Boda-Heggemann, Judit; Walter, Cornelia; Rahn, Angelika; Wertz, Hansjoerg; Loeb, Iris; Lohr, Frank; Wenz, Frederik

2006-01-01

Purpose: The repositioning accuracy of mask-based fixation systems has been assessed with two-dimensional/two-dimensional or two-dimensional/three-dimensional (3D) matching. We analyzed the accuracy of commercially available head mask systems, using true 3D/3D matching, with X-ray volume imaging and cone-beam CT. Methods and Materials: Twenty-one patients receiving radiotherapy (intracranial/head-and-neck tumors) were evaluated (14 patients with rigid and 7 with thermoplastic masks). X-ray volume imaging was analyzed online and offline separately for the skull and neck regions. Translation/rotation errors of the target isocenter were analyzed. Four patients were treated to neck sites. For these patients, repositioning was aided by additional body tattoos. A separate analysis of the setup error on the basis of the registration of the cervical vertebra was performed. The residual error after correction and intrafractional motility were calculated. Results: The mean length of the displacement vector for rigid masks was 0.312 ± 0.152 cm (intracranial) and 0.586 ± 0.294 cm (neck). For the thermoplastic masks, the value was 0.472 ± 0.174 cm (intracranial) and 0.726 ± 0.445 cm (neck). Rigid masks with body tattoos had a displacement vector length in the neck region of 0.35 ± 0.197 cm. The intracranial residual error and intrafractional motility after X-ray volume imaging correction for rigid masks was 0.188 ± 0.074 cm, and was 0.134 ± 0.14 cm for thermoplastic masks. Conclusions: The results of our study have demonstrated that rigid masks have a high intracranial repositioning accuracy per se. Given the small residual error and intrafractional movement, thermoplastic masks may also be used for high-precision treatments when combined with cone-beam CT. The neck region repositioning accuracy was worse than the intracranial accuracy in both cases. However, body tattoos and image guidance improved the accuracy. Finally, the combination of both mask systems with 3D

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

International Nuclear Information System (INIS)

Eriksson, A; Österroos, A; Hassan, S; Gullbo, J; Rickardson, L; Jarvius, M; Nygren, P; Fryknäs, M; Höglund, M; Larsson, R

2015-01-01

To find drugs suitable for repositioning for use against leukemia, samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well as peripheral blood mononuclear cells (PBMC) were tested in response to 1266 compounds from the LOPAC 1280 library (Sigma). Twenty-five compounds were defined as hits with activity in all leukemia subgroups (<50% cell survival compared with control) at 10 μM drug concentration. Only one of these compounds, quinacrine, showed low activity in normal PBMCs and was therefore selected for further preclinical evaluation. Mining the NCI-60 and the NextBio databases demonstrated leukemia sensitivity and the ability of quinacrine to reverse myeloid leukemia gene expression. Mechanistic exploration was performed using the NextBio bioinformatic software using gene expression analysis of drug exposed acute myeloid leukemia cultures (HL-60) in the database. Analysis of gene enrichment and drug correlations revealed strong connections to ribosomal biogenesis nucleoli and translation initiation. The highest drug–drug correlation was to ellipticine, a known RNA polymerase I inhibitor. These results were validated by additional gene expression analysis performed in-house. Quinacrine induced early inhibition of protein synthesis supporting these predictions. The results suggest that quinacrine have repositioning potential for treatment of acute myeloid leukemia by targeting of ribosomal biogenesis

A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information.

Science.gov (United States)

Luo, Yunan; Zhao, Xinbin; Zhou, Jingtian; Yang, Jinglin; Zhang, Yanqing; Kuang, Wenhua; Peng, Jian; Chen, Ligong; Zeng, Jianyang

2017-09-18

The emergence of large-scale genomic, chemical and pharmacological data provides new opportunities for drug discovery and repositioning. In this work, we develop a computational pipeline, called DTINet, to predict novel drug-target interactions from a constructed heterogeneous network, which integrates diverse drug-related information. DTINet focuses on learning a low-dimensional vector representation of features, which accurately explains the topological properties of individual nodes in the heterogeneous network, and then makes prediction based on these representations via a vector space projection scheme. DTINet achieves substantial performance improvement over other state-of-the-art methods for drug-target interaction prediction. Moreover, we experimentally validate the novel interactions between three drugs and the cyclooxygenase proteins predicted by DTINet, and demonstrate the new potential applications of these identified cyclooxygenase inhibitors in preventing inflammatory diseases. These results indicate that DTINet can provide a practically useful tool for integrating heterogeneous information to predict new drug-target interactions and repurpose existing drugs.Network-based data integration for drug-target prediction is a promising avenue for drug repositioning, but performance is wanting. Here, the authors introduce DTINet, whose performance is enhanced in the face of noisy, incomplete and high-dimensional biological data by learning low-dimensional vector representations.

Beyond "the West as Method": Repositioning the Japanese Education Research Communities in/against the Global Structure of Academic Knowledge

Science.gov (United States)

Takayama, Keita

2016-01-01

Drawing on the recent critiques of the global knowledge economy of social science research, this article explores possible ways in which the Japanese education research communities can reposition themselves in the wider international education research community. The premises of this discussion are that there exists a global structure of academic…

Impact of PET/CT system, reconstruction protocol, data analysis method, and repositioning on PET/CT precision: An experimental evaluation using an oncology and brain phantom.

Science.gov (United States)

Mansor, Syahir; Pfaehler, Elisabeth; Heijtel, Dennis; Lodge, Martin A; Boellaard, Ronald; Yaqub, Maqsood

2017-12-01

In longitudinal oncological and brain PET/CT studies, it is important to understand the repeatability of quantitative PET metrics in order to assess change in tracer uptake. The present studies were performed in order to assess precision as function of PET/CT system, reconstruction protocol, analysis method, scan duration (or image noise), and repositioning in the field of view. Multiple (repeated) scans have been performed using a NEMA image quality (IQ) phantom and a 3D Hoffman brain phantom filled with 18 F solutions on two systems. Studies were performed with and without randomly (PET/CT, especially in the case of smaller spheres (PET metrics depends on the combination of reconstruction protocol, data analysis methods and scan duration (scan statistics). Moreover, precision was also affected by phantom repositioning but its impact depended on the data analysis method in combination with the reconstructed voxel size (tissue fraction effect). This study suggests that for oncological PET studies the use of SUV peak may be preferred over SUV max because SUV peak is less sensitive to patient repositioning/tumor sampling. © 2017 The Authors. Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Augmented reality as an aid in maxillofacial surgery: validation of a wearable system allowing maxillary repositioning.

Science.gov (United States)

Badiali, Giovanni; Ferrari, Vincenzo; Cutolo, Fabrizio; Freschi, Cinzia; Caramella, Davide; Bianchi, Alberto; Marchetti, Claudio

2014-12-01

We present a newly designed, localiser-free, head-mounted system featuring augmented reality as an aid to maxillofacial bone surgery, and assess the potential utility of the device by conducting a feasibility study and validation. Our head-mounted wearable system facilitating augmented surgery was developed as a stand-alone, video-based, see-through device in which the visual features were adapted to facilitate maxillofacial bone surgery. We implement a strategy designed to present augmented reality information to the operating surgeon. LeFort1 osteotomy was chosen as the test procedure. The system is designed to exhibit virtual planning overlaying the details of a real patient. We implemented a method allowing performance of waferless, augmented-reality assisted bone repositioning. In vitro testing was conducted on a physical replica of a human skull, and the augmented reality system was used to perform LeFort1 maxillary repositioning. Surgical accuracy was measured with the aid of an optical navigation system that recorded the coordinates of three reference points (located in anterior, posterior right, and posterior left positions) on the repositioned maxilla. The outcomes were compared with those expected to be achievable in a three-dimensional environment. Data were derived using three levels of surgical planning, of increasing complexity, and for nine different operators with varying levels of surgical skill. The mean error was 1.70 ± 0.51 mm. The axial errors were 0.89 ± 0.54 mm on the sagittal axis, 0.60 ± 0.20 mm on the frontal axis, and 1.06 ± 0.40 mm on the craniocaudal axis. The simplest plan was associated with a slightly lower mean error (1.58 ± 0.37 mm) compared with the more complex plans (medium: 1.82 ± 0.71 mm; difficult: 1.70 ± 0.45 mm). The mean error for the anterior reference point was lower (1.33 ± 0.58 mm) than those for both the posterior right (1.72 ± 0.24 mm) and posterior left points (2.05 ± 0.47 mm). No significant difference

Nudging at the checkout counter : A longitudinal study of the effect of a food repositioning nudge on healthy food choice

NARCIS (Netherlands)

van Gestel, L.C.; Kroese, F.M.; de Ridder, D.T.D.

2018-01-01

Objective The current study is a longitudinal conceptual replication and aimed to investigate the effect of a food repositioning nudge on healthy food choice in a kiosk. Design During eight weeks, sales data were collected. The former four weeks formed the baseline phase and the latter four weeks

Head repositioning errors in normal student volunteers: a possible tool to assess the neck's neuromuscular system

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Gudavalli M Ram

2006-03-01

Full Text Available Abstract Background A challenge for practitioners using spinal manipulation is identifying when an intervention is required. It has been recognized that joint pain can interfere with the ability to position body parts accurately and that the recent history of muscle contraction can play a part in that interference. In this study, we tested whether repositioning errors could be induced in a normal population by contraction or shortening of the neck muscles. Methods In the experimental protocol, volunteers free of neck problems first found a comfortable neutral head posture with eyes closed. They deconditioned their cervical muscles by moving their heads 5 times in either flexion/extension or lateral flexion and then attempted to return to the same starting position. Two conditioning sequences were interspersed within the task: hold the head in an extended or laterally flexed position for 10 seconds; or hold a 70% maximum voluntary contraction in the same position for 10 seconds. A computer-interfaced electrogoniometer was used to measure head position while a force transducer coupled to an auditory alarm signaled the force of isometric contraction. The difference between the initial and final head orientation was calculated in 3 orthogonal planes. Analysis of variance (1-way ANOVA with a blocking factor (participants was used to detect differences in proprioceptive error among the conditioning sequences while controlling for variation between participants. Results Forty-eight chiropractic students participated: 36 males and 12 females, aged 28.2 ± 4.8 yrs. During the neck extension test, actively contracting the posterior neck muscles evoked an undershoot of the target position by 2.1° (p Conclusion The results suggest that the recent history of cervical paraspinal muscle contraction can influence head repositioning in flexion/extension. To our knowledge this is the first time that muscle mechanical history has been shown to influence

Linear Subpixel Learning Algorithm for Land Cover Classification from WELD using High Performance Computing

Science.gov (United States)

Ganguly, S.; Kumar, U.; Nemani, R. R.; Kalia, S.; Michaelis, A.

2017-12-01

In this work, we use a Fully Constrained Least Squares Subpixel Learning Algorithm to unmix global WELD (Web Enabled Landsat Data) to obtain fractions or abundances of substrate (S), vegetation (V) and dark objects (D) classes. Because of the sheer nature of data and compute needs, we leveraged the NASA Earth Exchange (NEX) high performance computing architecture to optimize and scale our algorithm for large-scale processing. Subsequently, the S-V-D abundance maps were characterized into 4 classes namely, forest, farmland, water and urban areas (with NPP-VIIRS - national polar orbiting partnership visible infrared imaging radiometer suite nighttime lights data) over California, USA using Random Forest classifier. Validation of these land cover maps with NLCD (National Land Cover Database) 2011 products and NAFD (North American Forest Dynamics) static forest cover maps showed that an overall classification accuracy of over 91% was achieved, which is a 6% improvement in unmixing based classification relative to per-pixel based classification. As such, abundance maps continue to offer an useful alternative to high-spatial resolution data derived classification maps for forest inventory analysis, multi-class mapping for eco-climatic models and applications, fast multi-temporal trend analysis and for societal and policy-relevant applications needed at the watershed scale.

Características de repositório educacional aberto para usuários de língua brasileira de sinais

Directory of Open Access Journals (Sweden)

Romario Antunes da Silva

Full Text Available O objetivo desse artigo é identificar as características que um repositório educacional aberto deve apresentar para atender as necessidade de informação dos alunos surdos e ouvintes do curso Letras Libras na modalidade a distância da Universidade Federal de Santa Catarina. Os objetivos específicos foram: a descrever o perfil dos alunos surdos e ouvintes; b examinar o uso das tecnologias da informação por esses alunos; e c identificar os documentos que um repositório deve apresentar para atender as necessidades de informação desses alunos. A pesquisa é exploratória, descritiva e qualitativo-quantitativa, e a análise foi realizada com estatística descritiva e análise de conteúdo. Conclui-se que os alunos utilizam o e-mail, as listas de discussão, o Messenger, ferramentas para compartilhamento de vídeos e os sites para surdos. Os alunos consideram muito importantes os processadores de texto, Messenger, Movie Maker, Media Player e planilhas para cálculo. Os alunos surdos consideram como documentos mais relevantes as videoaulas, dicionários e apostilas, e os alunos ouvintes, as videoaulas, os livros e as apostilas. O tipo de conteúdo requisitado são notícias sobre surdos, língua brasileira de sinais, tradução, tecnologia, linguística, aprendizagem do português, interpretação médico-jurídica e cultura surda. Os suportes requisitados para acesso à informação são os dicionários, vídeos, livros digitais e artigos. Os alunos preferem acessar as informações no repositório por meio de língua de sinais, legendas e em português.

Repositioning Strategy for Malaysian Companies Internationalization

Directory of Open Access Journals (Sweden)

Ismi Rajiani

2013-05-01

Full Text Available 1024x768 The rise of the emerging-market countries offers both developing and developed countries a unique opportunity to gain the benefits of a truly international economy. Consequently, it is imperative to advance our knowledge of emerging-market countries MNC emergence and competitiveness including Malaysian firms on how will they position their products strategically? Based on the framework of Porter’s Generic Strategy this paper is composed of price/ volume segments and impacts on product strategy theory. The aim is to identify crucial triggering cues and focus areas for Malaysian companies and measure what role these play in different segments. This study argues that some Malaysian companies will reposition themselves strategically when internationalizing and that they will focus on other factors or triggering cues when doing so not merely adapting the prevalent price leadership strategy. Normal 0 false false false IN X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

Robotic nephroureterectomy: a simplified approach requiring no patient repositioning or robot redocking.

Science.gov (United States)

Zargar, Homayoun; Krishnan, Jayram; Autorino, Riccardo; Akca, Oktay; Brandao, Luis Felipe; Laydner, Humberto; Samarasekera, Dinesh; Ko, Oliver; Haber, Georges-Pascal; Kaouk, Jihad H; Stein, Robert J

2014-10-01

Robotic technology is increasingly adopted in urologic surgery and a variety of techniques has been described for minimally invasive treatment of upper tract urothelial cancer (UTUC). To describe a simplified surgical technique of robot-assisted nephroureterectomy (RANU) and to report our single-center surgical outcomes. Patients with history of UTUC treated with this modality between April 2010 and August 2013 were included in the analysis. Institutional review board approval was obtained. Informed consent was signed by all patients. A simplified single-step RANU not requiring repositioning or robot redocking. Lymph node dissection was performed selectively. Descriptive analysis of patients' characteristics, perioperative outcomes, histopathology, and short-term follow-up data was performed. The analysis included 31 patients (mean age: 72.4±10.6 yr; mean body mass index: 26.6±5.1kg/m(2)). Twenty-six of 30 tumors (86%) were high grade. Mean tumor size was 3.1±1.8cm. Of the 31 patients, 13 (42%) had pT3 stage disease. One periureteric positive margin was noted in a patient with bulky T3 disease. The mean number of lymph nodes removed was 9.4 (standard deviation: 5.6; range: 3-21). Two of 14 patients (14%) had positive lymph nodes on final histology. No patients required a blood transfusion. Six patients experienced complications postoperatively, with only one being a high grade (Clavien 3b) complication. Median hospital stay was 5 d. Within the follow-up period, seven patients experienced bladder recurrences and four patients developed metastatic disease. Our RANU technique eliminates the need for patient repositioning or robot redocking. This technique can be safely reproduced, with surgical outcomes comparable to other established techniques. We describe a surgical technique using the da Vinci robot for a minimally invasive treatment of patients presenting with upper tract urothelial cancer. This technique can be safely implemented with good surgical outcomes

Next Generation Snow Cover Mapping: Can Future Hyperspectral Satellite Spectrometer Systems Improve Subpixel Snow-covered Area and Grain Size in the Sierra Nevada?

Science.gov (United States)

Hill, R.; Calvin, W. M.; Harpold, A.

2017-12-01

Mountain snow storage is the dominant source of water for humans and ecosystems in western North America. Consequently, the spatial distribution of snow-covered area is fundamental to both hydrological, ecological, and climate models. Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) data were collected along the entire Sierra Nevada mountain range extending from north of Lake Tahoe to south of Mt. Whitney during the 2015 and 2016 snow-covered season. The AVIRIS dataset used in this experiment consists of 224 contiguous spectral channels with wavelengths ranging 400-2500 nanometers at a 15-meter spatial pixel size. Data from the Sierras were acquired on four days: 2/24/15 during a very low snow year, 3/24/16 near maximum snow accumulation, and 5/12/16 and 5/18/16 during snow ablation and snow loss. Building on previous retrieval of subpixel snow-covered area algorithms that take into account varying grain size we present a model that analyzes multiple endmembers of varying snow grain size, vegetation, rock, and soil in segmented regions along the Sierra Nevada to determine snow-cover spatial extent, snow sub-pixel fraction, and approximate grain size. In addition, varying simulated models of the data will compare and contrast the retrieval of current snow products such as MODIS Snow-Covered Area and Grain Size (MODSCAG) and the Airborne Space Observatory (ASO). Specifically, does lower spatial resolution (MODIS), broader resolution bandwidth (MODIS), and limited spectral resolution (ASO) affect snow-cover area and grain size approximations? The implications of our findings will help refine snow mapping products for planned hyperspectral satellite spectrometer systems such as EnMAP (slated to launch in 2019), HISUI (planned for inclusion on the International Space Station in 2018), and HyspIRI (currently under consideration).

Estimation of sub-pixel water area on Tibet plateau using multiple endmembers spectral mixture spectral analysis from MODIS data

Science.gov (United States)

Cui, Qian; Shi, Jiancheng; Xu, Yuanliu

2011-12-01

Water is the basic needs for human society, and the determining factor of stability of ecosystem as well. There are lots of lakes on Tibet Plateau, which will lead to flood and mudslide when the water expands sharply. At present, water area is extracted from TM or SPOT data for their high spatial resolution; however, their temporal resolution is insufficient. MODIS data have high temporal resolution and broad coverage. So it is valuable resource for detecting the change of water area. Because of its low spatial resolution, mixed-pixels are common. In this paper, four spectral libraries are built using MOD09A1 product, based on that, water body is extracted in sub-pixels utilizing Multiple Endmembers Spectral Mixture Analysis (MESMA) using MODIS daily reflectance data MOD09GA. The unmixed result is comparing with contemporaneous TM data and it is proved that this method has high accuracy.

[Clinical research of the otolith abnormal migration during canalith repositioning procedures for posterior semicircular canal benign paroxysmal positional vertigo].

Science.gov (United States)

Ou, Yongkang; Zheng, Yiging; Zhu, Honglei; Chen, Ling; Zhong, Junwei; Tang, Xiaowu; Huang, Qiuhong; Xu, Yaodong

2015-01-01

To investigate the risk factor,type and characteristic nystagmus of the otolith abnormal migration during diagnosis and treatment for posterior semicircular canal benign paroxysmal positional vertigo (PSC-BPPV). The therapy and prevention is also discussed. Four hundred and seventy-nine patients with PSC-BPPV were treated by Epley's canalith repositioning procedures(CRP) from March 2009 to March 2012. We observed otolith abnormal migration complicating during diagnosis and treatment. According the type of otolith abnormal migration, the additional repositioning maneuver was performed. The rate of complication was 8. 1%(39/479), with canal conversion in 5.4%(26/479) and primarily canal reentry in 2.7%(13/479). The rate of incidence of conversion to horizontal canal conversion and anterior canal were 4. 8%(23/479)and 0. 6%(3/479) respectively. All the patient was cured in follow up. The risk factors were unappropriated head movement during or after CRP, including another Dix-Hallpike were performed immediately. To prevent the complications,the pathognostic positioning sequence and angle of head rotation are commenced during CRP. Appropriate short time postural restrictions post-treatment is necessary. Careful observation of nystagrnus variation is crucial to determine the otolith abnormal migration.

Applying Lean-Six-Sigma Methodology in radiotherapy: Lessons learned by the breast daily repositioning case.

Science.gov (United States)

Mancosu, Pietro; Nicolini, Giorgia; Goretti, Giulia; De Rose, Fiorenza; Franceschini, Davide; Ferrari, Chiara; Reggiori, Giacomo; Tomatis, Stefano; Scorsetti, Marta

2018-03-06

Lean Six Sigma Methodology (LSSM) was introduced in industry to provide near-perfect services to large processes, by reducing improbable occurrence. LSSM has been applied to redesign the 2D-2D breast repositioning process (Lean) by the retrospective analysis of the database (Six Sigma). Breast patients with daily 2D-2D matching before RT were considered. The five DMAIC (define, measure, analyze, improve, and control) LSSM steps were applied. The process was retrospectively measured over 30 months (7/2014-12/2016) by querying the RT Record&Verify database. Two Lean instruments (Poka-Yoke and Visual Management) were considered for advancing the process. The new procedure was checked over 6 months (1-6/2017). 14,931 consecutive shifts from 1342 patients were analyzed. Only 0.8% of patients presented median shifts >1 cm. The major observed discrepancy was the monthly percentage of fractions with almost zero shifts (AZS = 13.2% ± 6.1%). Ishikawa fishbone diagram helped in defining the main discrepancy con-causes. Procedure harmonization involving a multidisciplinary team to increase confidence in matching procedure was defined. AZS was reduced to 4.8% ± 0.6%. Furthermore, distribution symmetry improvement (Skewness moved from 1.4 to 1.1) and outlier reduction, verified by Kurtosis diminution, demonstrated a better "normalization" of the procedure after the LSSM application. LSSM was implemented in a RT department, allowing to redesign the breast repositioning matching procedure. Copyright © 2018 Elsevier B.V. All rights reserved.

Urban Image Classification: Per-Pixel Classifiers, Sub-Pixel Analysis, Object-Based Image Analysis, and Geospatial Methods. 10; Chapter

Science.gov (United States)

Myint, Soe W.; Mesev, Victor; Quattrochi, Dale; Wentz, Elizabeth A.

2013-01-01

Remote sensing methods used to generate base maps to analyze the urban environment rely predominantly on digital sensor data from space-borne platforms. This is due in part from new sources of high spatial resolution data covering the globe, a variety of multispectral and multitemporal sources, sophisticated statistical and geospatial methods, and compatibility with GIS data sources and methods. The goal of this chapter is to review the four groups of classification methods for digital sensor data from space-borne platforms; per-pixel, sub-pixel, object-based (spatial-based), and geospatial methods. Per-pixel methods are widely used methods that classify pixels into distinct categories based solely on the spectral and ancillary information within that pixel. They are used for simple calculations of environmental indices (e.g., NDVI) to sophisticated expert systems to assign urban land covers. Researchers recognize however, that even with the smallest pixel size the spectral information within a pixel is really a combination of multiple urban surfaces. Sub-pixel classification methods therefore aim to statistically quantify the mixture of surfaces to improve overall classification accuracy. While within pixel variations exist, there is also significant evidence that groups of nearby pixels have similar spectral information and therefore belong to the same classification category. Object-oriented methods have emerged that group pixels prior to classification based on spectral similarity and spatial proximity. Classification accuracy using object-based methods show significant success and promise for numerous urban 3 applications. Like the object-oriented methods that recognize the importance of spatial proximity, geospatial methods for urban mapping also utilize neighboring pixels in the classification process. The primary difference though is that geostatistical methods (e.g., spatial autocorrelation methods) are utilized during both the pre- and post

Efficacy of the Yumeiho therapy massage on Repositioning error, Range of motion trunk Flexation and functional power in women volleyball players with Hyper lordosis

Directory of Open Access Journals (Sweden)

Yousef yarahmadi

2018-03-01

Conclusion: results showed that the effect of Yumeiho therapy massage on repositioning error, Flexation range of motion trunk and functional power had a significant. It therapists recommended to include Yumeiho therapy massage in order to enhance these variables.

Physics characteristics of a CANDU-600 with repositional adjuster rods fuelled with MOX or natural uranium

International Nuclear Information System (INIS)

Boczar, P.G.

1985-06-01

Repositioning the adjuster rods in 4 axial banks in future CANDU-600 reactors would permit the flexibility of grading the inner and outer banks to achieve optimal flattening of the axial power distribution for any particular fuel. With the 4 banks identical, acceptable axial power profiles can be achieved for both MOX and natural uranium fuels. Future work is to be directed at assessing the impact of lower zone controller and shutoff rod worth in the configuration of reactivity devices considered here, and if necessary, in identifying means of increasing their worth

Children's experiences of the repositioning of their psychological birth order in a reconstituted family / Lizelle van Jaarsveld.

OpenAIRE

Van Jaarsveld, Lizelle

2012-01-01

The aim of this study is to explore and describe children’s experiences of the repositioning of their psychological birth order in a reconstituted family. The aim of this study is also to contribute to a better understanding of this phenomenon to aid the parents of these children as well as professionals working with such families. The systems theory was used as the meta-theory of this study. Gestalt field theory formed the connection between the systems theory and Adlerian theory, to port...

Automatic Thresholding for Frame-Repositioning Using External Tracking in PET Brain Imaging

DEFF Research Database (Denmark)

Olesen, Oline Vinter; Keller, Sune; Sibomana, Merence

2010-01-01

Motion correction (MC) in positron emission tomography (PET) brain imaging become of higher importance with increasing scanner resolution. Several motion correction methods have been suggested and so far the Polaris Vicra tracking system has been the preferred one for motion registration. We...... present an automated algorithm for dividing PET acquisitions into subframes based on the registered head motion to correct for intra-frame motion with the frame repositioning MC method. The method is tested on real patient data (five 11C-SB studies and five 11C-PIB studies) and compared with an image...... based registration method (AIR). Quantitative evaluation was done using a correlation measure. The study shows that MC improves the correlation of the PET images and that AIR performed slightly better than the Polaris Vicra. We found significant intra-frame motion of 1-5 mm in 9 frames...

Ocular VEMPs indicate repositioning of otoconia to the utricle after successful liberatory maneuvers in benign paroxysmal positioning vertigo

Science.gov (United States)

BREMOVA, TATIANA; BAYER, OTMAR; AGRAWAL, YURI; KREMMYDA, OLYMPIA; BRANDT, THOMAS; TEUFEL, JULIAN; STRUPP, MICHAEL

2014-01-01

Conclusions This study showed a transient increase of ocular vestibular evoked myogenic potential (oVEMP) amplitudes in the affected ear after successful liberatory maneuvers and no changes in cervical VEMP (cVEMP) amplitudes. These findings support the hypothesis that successful liberatory maneuvers can lead to a repositioning of otoconia to the utricle. Objectives To evaluate whether oVEMP amplitudes increase after successful liberatory maneuvers in patients with posterior semicircular canal benign paroxysmal positioning vertigo (pc-BPPV), while cVEMP amplitudes do not change. These findings may indicate a successful repositioning of dislodged otoconia to the utricular macula, but not to the saccular macula. Methods Thirty patients with unilateral pc-BPPV were prospectively examined with bone-conducted oVEMP and air-conducted cVEMP at four time points: before, after, 1 week after, and 1 month after the liberatory maneuvers (Sémont maneuvers). Results At the 1-week follow-up, 20 of 30 patients were asymptomatic (responders); BPPV could still be induced in the other 10 (non-responders). In responders the mean n10 amplitude on the affected side increased from 12 ± 6.5 μV at baseline (before the treatment) to 15.9 ± 7.1 μV at 1 week after treatment; this increase was significantly (p = 0.001) higher in responders than in non-responders. cVEMP did not differ significantly. PMID:24245699

A Prospective, Descriptive, Quality Improvement Study to Investigate the Impact of a Turn-and-Position Device on the Incidence of Hospital-acquired Sacral Pressure Ulcers and Nursing Staff Time Needed for Repositioning Patients.

Science.gov (United States)

Hall, Kimberly D; Clark, Rebecca C

2016-11-01

Patients in critical care areas are at risk for developing hospital-acquired pressure ulcers (HAPUs) due to their physical conditions and limited ability to reposition themselves. A prospective, 2-phase quality improvement study was conducted from September to November 2011 and from February to April 2012 in 1 medical and 1 surgical ICU to investigate the impact of a turn-and-assist device on the incidence of HAPUs and the time and personnel required to reposition patients reported as person/minutes (staff x minutes). A consecutive, convenience sample of patients was selected from newly admitted ICU patients who were at least 18 years old, nonambulatory, and required 2 or more people to assist with turning and repositioning. Sociodemographic data (patient age, gender, height, weight, body mass index, incontinence status); total Braden score and subscores for Activity, Mobility, and Moisture on admission; length of ICU stay and ventilator days; and sacral pressure ulcer incidence and stage and turn-and-assist data were collected. Fifty (50) patients participated in each phase. In phase 1, standard care for positioning included pillows, underpads, standard low-air-loss beds and additional staff as required for turning. In phase 2, the study product replaced standard care repositioning products including pillows; and a larger disposable moisture-wicking underpad (included as part of the turn study project kit) was substituted for the smaller, standard moisture-wicking disposable underpad. Turning procedures were timed with a stopwatch. Data were collected for a total of 32 hours during the observation periods; all patients were followed from admission until discharge from the ICU for a maximum of 14 days. T-tests were used to compare patient characteristics and person-minutes needed for repositioning differences, and Fisher's exact test was used to compare the incidence of sacral HAPUs during phase 1 and phase 2 of the study. No statistically significant

Distal phalanx amputation with delayed presentation and successful reconstruction with reposition and flap after 2 weeks

Directory of Open Access Journals (Sweden)

Jefferson Braga-Silva

2016-01-01

Full Text Available Traumatic finger amputations are common, causing significant functional and cosmetic deficits. Microsurgical replantation techniques are the mainstay of treatment for most such injuries although they require adequate conservation of the amputated segment for a successful result. In distal finger amputations, replantation is the procedure of choice, as long as the amputated fragment is viable. If replantation is not an option, reposition + flap using a neurovascular flap can be an efficient option, as this offers improved skin coverage. To the best of our knowledge, this case illustrates the longest cold ischaemic time with a successful outcome.

Persistent otolith dysfunction even after successful repositioning in benign paroxysmal positional vertigo.

Science.gov (United States)

Kim, Eui-Joong; Oh, Sun-Young; Kim, Ji Soo; Yang, Tae-Ho; Yang, Si-Young

2015-11-15

To evaluate utricular and saccular function during the acute and resolved phases of BPPV, ocular and cervical vestibular evoked myogenic potentials (VEMPs) were studied in 112 patients with BPPV and 50 normal controls in a referral-based University Hospital. Ocular (oVEMPs) and cervical VEMPs (cVEMPs) were induced using air-conducted sound (1000Hz tone burst, 100dB normal hearing level) at the time of initial diagnosis and 2 months after successful repositioning in patients with BPPV, and the results were compared with those of the controls. Abnormalities of cVEMPs and oVEMPs in patients with BPPV were prevalent and significantly higher compare to the healthy control group (potolithic dysfunction was often shown by persistently reduced or absent cervical and ocular VEMPs, suggesting that BPPV may be caused by significant bilateral damage to the otolith organs. Copyright © 2015 Elsevier B.V. All rights reserved.

Effectiveness of Otolith Repositioning Maneuvers and Vestibular Rehabilitation exercises in elderly people with Benign Paroxysmal Positional Vertigo: a systematic review

OpenAIRE

Ribeiro, Karyna Figueiredo; Oliveira, Bruna Steffeni; Freitas, Raysa V.; Ferreira, Lidiane M.; Deshpande, Nandini; Guerra, Ricardo O.

2018-01-01

Abstract Introduction Benign Paroxysmal Positional Vertigo is highly prevalent in elderly people. This condition is related to vertigo, hearing loss, tinnitus, poor balance, gait disturbance, and an increase in risk of falls, leading to postural changes and quality of life decreasing. Objective To evaluate the outcomes obtained by clinical trials on the effectiveness of Otolith Repositioning Maneuver and Vestibular Rehabilitation exercises in the treatment of Benign Paroxysmal Positional Ve...

A Subpixel Classification of Multispectral Satellite Imagery for Interpetation of Tundra-Taiga Ecotone Vegetation (Case Study on Tuliok River Valley, Khibiny, Russia)

Science.gov (United States)

Mikheeva, A. I.; Tutubalina, O. V.; Zimin, M. V.; Golubeva, E. I.

2017-12-01

The tundra-taiga ecotone plays significant role in northern ecosystems. Due to global climatic changes, the vegetation of the ecotone is the key object of many remote-sensing studies. The interpretation of vegetation and nonvegetation objects of the tundra-taiga ecotone on satellite imageries of a moderate resolution is complicated by the difficulty of extracting these objects from the spectral and spatial mixtures within a pixel. This article describes a method for the subpixel classification of Terra ASTER satellite image for vegetation mapping of the tundra-taiga ecotone in the Tuliok River, Khibiny Mountains, Russia. It was demonstrated that this method allows to determine the position of the boundaries of ecotone objects and their abundance on the basis of quantitative criteria, which provides a more accurate characteristic of ecotone vegetation when compared to the per-pixel approach of automatic imagery interpretation.

Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors

Energy Technology Data Exchange (ETDEWEB)

Y Cho; J Vermeire; J Merkel; L Leng; X Du; R Bucala; M Cappello; E Lolis

2011-12-31

The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new pharmacophores. Hookworms are blood-feeding, intestinal nematode parasites that infect up to 600 million people worldwide. Vaccination with recombinant Ancylostoma ceylanicum macrophage migration inhibitory factor (rAceMIF) provided partial protection from disease, thus establishing a 'proof-of-concept' for targeting AceMIF to prevent or treat infection. A high-throughput screen (HTS) against rAceMIF identified six AceMIF-specific inhibitors. A nonsteroidal anti-inflammatory drug (NSAID), sodium meclofenamate, could be tested in an animal model to assess the therapeutic efficacy in treating hookworm disease. Furosemide, an FDA-approved diuretic, exhibited submicromolar inhibition of rAceMIF tautomerase activity. Structure-activity relationships of a pharmacophore based on furosemide included one analog that binds similarly to the active site, yet does not inhibit the Na-K-Cl symporter (NKCC1) responsible for diuretic activity.

Repositioning the use of the Bible towards a mission-oriented theological education

Directory of Open Access Journals (Sweden)

Adekunle O. Dada

2013-02-01

Full Text Available It is an undeniable fact that mission remains the cardinal essence of the Church. However, in Africa and in Nigeria, the Church seems to have lost focus regarding the main reason for its existence, namely mission. One of the factors responsible for this may be the form of theological education in vogue. In view of this anomaly, this paper reflects on how the study of the Bible, which serves as the primary basis for theological education in some institutions, can be repositioned to enhance a mission-oriented theological education. The importance of proper interpretation of the Bible in enhancing missions can be premised on the fact that a sound biblical hermeneutics is prerequisite to the formulation of an effective and functional theology of missions. If our theology of mission is faulty, the practice cannot be anything but flawed. In view of this, the paper explores ways in which the Bible can be meaningfully studied in order to promote a mission-oriented theological education.

Surgical treatment of adolescent internal condylar resorption (AICR) with articular disc repositioning and orthognathic surgery in the growing patient?a pilot study

OpenAIRE

Bodine, Trevor P.; Wolford, Larry M.; Araujo, Eustaquio; Oliver, Donald R.; Buschang, Peter H.

2016-01-01

Abstract Background The aim of this study was to better understand how surgical repositioning and stabilization of anteriorly displaced articular discs using the Mitek mini-anchor technique affects condylar growth in growing patients with adolescent internal condylar resorption (AICR). Methods Twenty-two adolescent patients diagnosed with AICR and anterior temporomandibular disc displacement were compared to untreated control subjects without AICR matched for age, sex, and Angle classificatio...

Automatic optimal filament segmentation with sub-pixel accuracy using generalized linear models and B-spline level-sets.

Science.gov (United States)

Xiao, Xun; Geyer, Veikko F; Bowne-Anderson, Hugo; Howard, Jonathon; Sbalzarini, Ivo F

2016-08-01

Biological filaments, such as actin filaments, microtubules, and cilia, are often imaged using different light-microscopy techniques. Reconstructing the filament curve from the acquired images constitutes the filament segmentation problem. Since filaments have lower dimensionality than the image itself, there is an inherent trade-off between tracing the filament with sub-pixel accuracy and avoiding noise artifacts. Here, we present a globally optimal filament segmentation method based on B-spline vector level-sets and a generalized linear model for the pixel intensity statistics. We show that the resulting optimization problem is convex and can hence be solved with global optimality. We introduce a simple and efficient algorithm to compute such optimal filament segmentations, and provide an open-source implementation as an ImageJ/Fiji plugin. We further derive an information-theoretic lower bound on the filament segmentation error, quantifying how well an algorithm could possibly do given the information in the image. We show that our algorithm asymptotically reaches this bound in the spline coefficients. We validate our method in comprehensive benchmarks, compare with other methods, and show applications from fluorescence, phase-contrast, and dark-field microscopy. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Discovery of new erbB4 inhibitors: Repositioning an orphan chemical library by inverse virtual screening.

Science.gov (United States)

Giordano, Assunta; Forte, Giovanni; Massimo, Luigia; Riccio, Raffaele; Bifulco, Giuseppe; Di Micco, Simone

2018-04-12

Inverse Virtual Screening (IVS) is a docking based approach aimed to the evaluation of the virtual ability of a single compound to interact with a library of proteins. For the first time, we applied this methodology to a library of synthetic compounds, which proved to be inactive towards the target they were initially designed for. Trifluoromethyl-benzenesulfonamides 3-21 were repositioned by means of IVS identifying new lead compounds (14-16, 19 and 20) for the inhibition of erbB4 in the low micromolar range. Among these, compound 20 exhibited an interesting value of IC 50 on MCF7 cell lines, thus validating IVS in lead repurposing. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Effect of fibular repositioning taping in adult basketball players with chronic ankle instability: a randomized, placebo-controlled, crossover trial.

Science.gov (United States)

Alves, Yanina; Ribeiro, Fernando; Silva, Anabela G

2017-07-05

Chronic ankle instability presents a high incidence and prevalence in basketbal players. It's important to develop strategies to reduce the functional and mechanical limitations resulting from this condition. To compare the effect of Mulligan ́s fibular repositioning taping with a placebo taping immediatly after application and after a running test (Yo-Yo IRT). 16 adult basketball players (10 male, 6 female) with chronic ankle instability and mean age 21.50 ± 2.76 years old. Assessment of static postural control (15 seconds of unipedal stance test with eyes closed in a force platform), functional performance (figure 8 hop test and lateral hop test) and neuromuscular control (peroneus longus latency time in sudden inversion) in two conditions: Mulligan and Placebo. No significant effect was found for the intervantion factor in both hop tests (p>0.170), but there was a significant effect for the time factor (p<0.03). For the peroneus longus latency time, there was a significant interaction between factors (p=0.028) and also for time (p=0.042). No significant effect was found for any of the static postural control variables (area, speed and total displacement) (p≥0.10). There was no differences between Mulligan's fibular repositioning taping and Placebo taping in postural control and functional performance in basketball players with chronic ankle instability. However, Mulligan's taping appears to reduce peroneus longus latency time after a running when compared with a placebo taping.

Lip Repositioning Technique With Smile Elevator Muscle Containment - A Novel Cosmetic Approach for Gummy Smile: Case Report.

Science.gov (United States)

Littuma, Gustavo Javier Salazar; de Souza, Humberto Cherem Mendez; Peñarrieta, Gabriella Mercedes; Magini, Ricardo de Souza; Saba-Chujfi, Eduardo

Excessive gingival display (EGD) is a challenge for dentists attempting to provide their patients a pleasant smile. EGD associated with hyperactivity of the smile elevator muscles can be treated with various surgical techniques; regardless of which technique is used, to achieve a predictable result with long-term stability limiting upper lip movement when the patient smiles, a firm muscle containment is imperative. This report describes an innovative suture procedure associated with a lip repositioning technique aimed at maintaining the traction and containment of the smile elevator muscles. This case demonstrates a successful and stable result for excessive gingival exposure, addressing and satisfying a patient's esthetic concerns.

The Dix-Hallpike test and the canalith repositioning maneuver.

Science.gov (United States)

Viirre, Erik; Purcell, Ian; Baloh, Robert W

2005-01-01

The Dix-Hallpike test and the canalith repositioning maneuver (CRM) are used to diagnose and treat benign positional vertigo (BPV). Dix-Hallpike is the standard procedure for diagnosis of BPV, but if the horizontal canal is not tested for BPV and the Dix-Hallpike is only carried out once, the condition may not be diagnosed and appropriately treated. We describe our method of testing for BPV and treating it with CRM. The Dix-Hallpike test involves rapidly moving the patient from a sitting position to "head hanging," where the patient's head is at least 10 degrees below horizontal. This is performed initially for the posterior semicircular canals. If these movements fail to elicit vertigo and nystagmus, tests of the horizontal semicircular canals are performed by laying the patient on each side. Importantly, if there is no vertigo or nystagmus elicited by testing the horizontal semi-circular canals, the posterior semicircular canals are tested again. It appears that being held in the head hanging positions and then left and right lateral positions will often allow the canaliths to collect such that the Dix-Hallpike test will become positive. Failure to repeat the tests of the posterior semicircular canals may result in a falsely negative test. Testing the horizontal canals and repeating the Dix-Hallpike test will reduce the likelihood of patients undergoing extra testing or other consequences of misdiagnosis. If, during any of this testing, a movement elicits vertigo or nystagmus, the appropriate CRM is then carried out.

DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue.

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Wang, QuanQiu; Xu, Rong

2015-01-01

Dengue is a viral disease of expanding global incidence without cures. Here we present a drug repositioning system (DenguePredict) leveraging upon a unique drug treatment database and vast amounts of disease- and drug-related data. We first constructed a large-scale genetic disease network with enriched dengue genetics data curated from biomedical literature. We applied a network-based ranking algorithm to find dengue-related diseases from the disease network. We then developed a novel algorithm to prioritize FDA-approved drugs from dengue-related diseases to treat dengue. When tested in a de-novo validation setting, DenguePredict found the only two drugs tested in clinical trials for treating dengue and ranked them highly: chloroquine ranked at top 0.96% and ivermectin at top 22.75%. We showed that drugs targeting immune systems and arachidonic acid metabolism-related apoptotic pathways might represent innovative drugs to treat dengue. In summary, DenguePredict, by combining comprehensive disease- and drug-related data and novel algorithms, may greatly facilitate drug discovery for dengue.

CASTOR: Cathode/Anode Satellite Thruster for Orbital Repositioning

Science.gov (United States)

Mruphy, Gloria A.

2010-01-01

The purpose of CASTOR (Cathode/Anode Satellite Thruster for Orbital Repositioning) satellite is to demonstrate in Low Earth Orbit (LEO) a nanosatellite that uses a Divergent Cusped Field Thruster (DCFT) to perform orbital maneuvers representative of an orbital transfer vehicle. Powered by semi-deployable solar arrays generating 165W of power, CASTOR will achieve nearly 1 km/s of velocity increment over one year. As a technology demonstration mission, success of CASTOR in LEO will pave the way for a low cost, high delta-V orbital transfer capability for small military and civilian payloads in support of Air Force and NASA missions. The educational objective is to engage graduate and undergraduate students in critical roles in the design, development, test, carrier integration and on-orbit operations of CASTOR as a supplement to their curricular activities. This program is laying the foundation for a long-term satellite construction program at MIT. The satellite is being designed as a part of AFRL's University Nanosatellite Program, which provides the funding and a framework in which student satellite teams compete for a launch to orbit. To this end, the satellite must fit within an envelope of 50cmx50cmx60cm, have a mass of less than 50kg, and meet stringent structural and other requirements. In this framework, the CASTOR team successfully completed PDR in August 2009 and CDR in April 2010 and will compete at FCR (Flight Competition Review) in January 2011. The complexity of the project requires implementation of many systems engineering techniques which allow for development of CASTOR from conception through FCR and encompass the full design, fabrication, and testing process.

Sub-pixel analysis to support graphic security after scanning at low resolution

Science.gov (United States)

Haas, Bertrand; Cordery, Robert; Gou, Hongmei; Decker, Steve

2006-02-01

Whether in the domain of audio, video or finance, our world tends to become increasingly digital. However, for diverse reasons, the transition from analog to digital is often much extended in time, and proceeds by long steps (and sometimes never completes). One such step is the conversion of information on analog media to digital information. We focus in this paper on the conversion (scanning) of printed documents to digital images. Analog media have the advantage over digital channels that they can harbor much imperceptible information that can be used for fraud detection and forensic purposes. But this secondary information usually fails to be retrieved during the conversion step. This is particularly relevant since the Check-21 act (Check Clearing for the 21st Century act) became effective in 2004 and allows images of checks to be handled by banks as usual paper checks. We use here this situation of check scanning as our primary benchmark for graphic security features after scanning. We will first present a quick review of the most common graphic security features currently found on checks, with their specific purpose, qualities and disadvantages, and we demonstrate their poor survivability after scanning in the average scanning conditions expected from the Check-21 Act. We will then present a novel method of measurement of distances between and rotations of line elements in a scanned image: Based on an appropriate print model, we refine direct measurements to an accuracy beyond the size of a scanning pixel, so we can then determine expected distances, periodicity, sharpness and print quality of known characters, symbols and other graphic elements in a document image. Finally we will apply our method to fraud detection of documents after gray-scale scanning at 300dpi resolution. We show in particular that alterations on legitimate checks or copies of checks can be successfully detected by measuring with sub-pixel accuracy the irregularities inherently introduced

Surgical treatment of adolescent internal condylar resorption (AICR) with articular disc repositioning and orthognathic surgery in the growing patient--a pilot study.

Science.gov (United States)

Bodine, Trevor P; Wolford, Larry M; Araujo, Eustaquio; Oliver, Donald R; Buschang, Peter H

2016-01-01

The aim of this study was to better understand how surgical repositioning and stabilization of anteriorly displaced articular discs using the Mitek mini-anchor technique affects condylar growth in growing patients with adolescent internal condylar resorption (AICR). Twenty-two adolescent patients diagnosed with AICR and anterior temporomandibular disc displacement were compared to untreated control subjects without AICR matched for age, sex, and Angle classification. Pre-surgical (T1 and T2) and post-surgical (T3 and T4) mandibular tracings were superimposed on natural stable structures to evaluate the horizontal, vertical, and total changes in the position of condylion. The treated group showed an overall decrease in condylar height pre-surgically and statistically significant changes in condylar growth direction between the pre- and post-surgical observation periods. Pre-surgically, the treated group showed significantly more posterior condylar growth than the control group; they also showed inferior condylar growth, while the controls showed superior growth. Controls and patients in the treated group showed no significant differences in condylar growth post-surgically. Adolescent patients diagnosed with AICR and anterior disc displacement treated with mandibular ramus and maxillary osteotomies, along with Mitek anchors to reposition internally deranged discs, showed post-surgical normalization of condylar growth.

Surgical treatment of adolescent internal condylar resorption (AICR with articular disc repositioning and orthognathic surgery in the growing patient—a pilot study

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Trevor P. Bodine

2016-01-01

Full Text Available Abstract Background The aim of this study was to better understand how surgical repositioning and stabilization of anteriorly displaced articular discs using the Mitek mini-anchor technique affects condylar growth in growing patients with adolescent internal condylar resorption (AICR. Methods Twenty-two adolescent patients diagnosed with AICR and anterior temporomandibular disc displacement were compared to untreated control subjects without AICR matched for age, sex, and Angle classification. Pre-surgical (T1 and T2 and post-surgical (T3 and T4 mandibular tracings were superimposed on natural stable structures to evaluate the horizontal, vertical, and total changes in the position of condylion. Results The treated group showed an overall decrease in condylar height pre-surgically and statistically significant changes in condylar growth direction between the pre- and post-surgical observation periods. Pre-surgically, the treated group showed significantly more posterior condylar growth than the control group; they also showed inferior condylar growth, while the controls showed superior growth. Controls and patients in the treated group showed no significant differences in condylar growth post-surgically. Conclusions Adolescent patients diagnosed with AICR and anterior disc displacement treated with mandibular ramus and maxillary osteotomies, along with Mitek anchors to reposition internally deranged discs, showed post-surgical normalization of condylar growth.

Pixel-Level Decorrelation and BiLinearly Interpolated Subpixel Sensitivity applied to WASP-29b

Science.gov (United States)

Challener, Ryan; Harrington, Joseph; Cubillos, Patricio; Blecic, Jasmina; Deming, Drake

2017-10-01

Measured exoplanet transit and eclipse depths can vary significantly depending on the methodology used, especially at the low S/N levels in Spitzer eclipses. BiLinearly Interpolated Subpixel Sensitivity (BLISS) models a physical, spatial effect, which is independent of any astrophysical effects. Pixel-Level Decorrelation (PLD) uses the relative variations in pixels near the target to correct for flux variations due to telescope motion. PLD is being widely applied to all Spitzer data without a thorough understanding of its behavior. It is a mathematical method derived from a Taylor expansion, and many of its parameters do not have a physical basis. PLD also relies heavily on binning the data to remove short time-scale variations, which can artifically smooth the data. We applied both methods to 4 eclipse observations of WASP-29b, a Saturn-sized planet, which was observed twice with the 3.6 µm and twice with the 4.5 µm channels of Spitzer's IRAC in 2010, 2011 and 2014 (programs 60003, 70084, and 10054, respectively). We compare the resulting eclipse depths and midpoints from each model, assess each method's ability to remove correlated noise, and discuss how to choose or combine the best data analysis methods. We also refined the orbit from eclipse timings, detecting a significant nonzero eccentricity, and we used our Bayesian Atmospheric Radiative Transfer (BART) code to retrieve the planet's atmosphere, which is consistent with a blackbody. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Análise da dinâmica de evolução das revistas científicas e bibliotecas digitais de teses e dissertações em acesso livre na área da Ciências da Comunicação: o caso do repositório Univerciencia.org

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Sueli Mara Soares Pinto Ferreira

2012-01-01

Full Text Available O crescimento do número de repositórios de revistas científicas e bibliotecas digitais de teses e dissertações em acesso aberto tem sido relatado em diversos estudos nos últimos anos. O objetivo deste artigo é avaliar, com enfoque específico na área da Ciência da Comunicação, como esse fenômeno tem acontecido e quais os seus impactos para essa comunidade científica. Apresentamos os principais resultados obtidos na construção de uma biblioteca digital federada, o repositório Univerciencia.org, o que nos permitiu avaliar como os repositórios em acesso aberto no padrão do protocolo OAI-PMH têm se difundido por entre as revistas e programas de pós-graduação da área, bem como padrões de uso e modos de operacionalização dos repositórios, fornecendo indícios que nos permitem avaliar como estes têm sido construídos.

Accuracy of Ultrasound-Based (BAT) Prostate-Repositioning: A Three-Dimensional On-Line Fiducial-Based Assessment With Cone-Beam Computed Tomography

International Nuclear Information System (INIS)

Boda-Heggemann, Judit; Koehler, Frederick Marc; Kuepper, Beate; Wolff, Dirk; Wertz, Hansjoerg; Mai, Sabine; Hesser, Juergen; Lohr, Frank; Wenz, Frederik

2008-01-01

Purpose: To assess the accuracy of ultrasound-based repositioning (BAT) before prostate radiation with fiducial-based three-dimensional matching with cone-beam computed tomography (CBCT). Patients and Methods: Fifty-four positionings in 8 patients with 125 I seeds/intraprostatic calcifications as fiducials were evaluated. Patients were initially positioned according to skin marks and after this according to bony structures based on CBCT. Prostate position correction was then performed with BAT. Residual error after repositioning based on skin marks, bony anatomy, and BAT was estimated by a second CBCT based on user-independent automatic fiducial registration. Results: Overall mean value (MV ± SD) residual error after BAT based on fiducial registration by CBCT was 0.7 ± 1.7 mm in x (group systematic error [M] = 0.5 mm; SD of systematic error [Σ] = 0.8 mm; SD of random error [σ] = 1.4 mm), 0.9 ± 3.3 mm in y (M = 0.5 mm, Σ = 2.2 mm, σ = 2.8 mm), and -1.7 ± 3.4 mm in z (M = -1.7 mm, Σ = 2.3 mm, σ = 3.0 mm) directions, whereas residual error relative to positioning based on skin marks was 2.1 ± 4.6 mm in x (M = 2.6 mm, Σ = 3.3 mm, σ = 3.9 mm), -4.8 ± 8.5 mm in y (M = -4.4 mm, Σ = 3.7 mm, σ = 6.7 mm), and -5.2 ± 3.6 mm in z (M = -4.8 mm, Σ = 1.7 mm, σ = 3.5mm) directions and relative to positioning based on bony anatomy was 0 ± 1.8 mm in x (M = 0.2 mm, Σ = 0.9 mm, σ = 1.1 mm), -3.5 ± 6.8 mm in y (M = -3.0 mm, Σ = 1.8 mm, σ = 3.7 mm), and -1.9 ± 5.2 mm in z (M = -2.0 mm, Σ = 1.3 mm, σ = 4.0 mm) directions. Conclusions: BAT improved the daily repositioning accuracy over skin marks or even bony anatomy. The results obtained with BAT are within the precision of extracranial stereotactic procedures and represent values that can be achieved with several users with different education levels. If sonographic visibility is insufficient, CBCT or kV/MV portal imaging with implanted fiducials are recommended

Contributions for Repositioning a Regional Strategy for Healthy Municipalities, Cities and Communities (HM&C): Results of a Pan-American Survey

Science.gov (United States)

Rice, Marilyn; Vizzotti, Carlos; Frassia, Romina; Vizzotti, Pablo; Akerman, Marco

2010-01-01

This article presents the results of the 1st Regional Survey of Healthy Municipalities, Cities and Communities (HM&C) carried out in 2008 by the Pan American Health Organization (PAHO) and ISALUD University of Argentina. It discusses the responses obtained from 12 countries in the Americas Region. Key informants in Argentina, Brazil, Chile, Colombia, Costa Rica, Cuba, Mexico, Paraguay, Peru, and Uruguay were selected and encouraged to answer the survey, while informants from Canada and Honduras answered voluntarily and were included in this analysis. The discussion of the results of the Survey provides insight into the current status of HM&C in the Region and suggests key topics for repositioning the Regional strategy relative to: (1) the conceptual identity and tools for HM&C; (2) challenging areas in the implementation process (scale, legal framework, and development of capacities); (3) related strategies and participatory processes such as the ways citizen empowerment in governance is supported; (4) the need to monitor and assess the impact of the HM&C strategy on the health and quality of life of the populations involved; and (5) the need for developing a strategic research and training agenda. The analysis and discussion of these results aims to provide useful input for repositioning the strategy in the Region and contributing to the emergence of a second generation of concepts and tools capable of meeting the developing priorities and needs currently faced by the HM&C strategy. PMID:20532989

Confined prostate cancer treated by conformational irradiation with intensity modulation with or without echography repositioning: is the dose received equivalent to the prescribed dose?; Cancer prostatique localise traite par irradiation conformationnelle avec modulation d'intensite avec ou sans repositionnement echographique: la dose recue est-elle equivalente a la dose prescrite?

Energy Technology Data Exchange (ETDEWEB)

Arnaud, A.; Peignaux, K.; Brenier, J.P.; Truc, G.; Naudy, S.; Maingon, P.; Crehange, G. [Centre Georges-Francois Leclerc, Dept. de Radiotherapie, 21 - Dijon (France); Regis, A. [CHU le Bocage, Service de Radiodiagnostic, 21 - Dijon (France); Deville, C.; Bonnetain, F. [Centre Georges-Francois Leclerc, Dept. de Biostatique, 21 - Dijon (France)

2006-11-15

The results suggest it would be possible to dispense a homogenous dose in agreement with the ICRU recommendations, nearer than the forward looking dose when the daily echographic repositioning is applied. This repositioning does not influence significantly the dosimetry for the risk organs. These results will validated in a bigger population. (N.C.)

Strategic positioning and repositioning of oil companies in the upstream business: understanding the historical evolution of firms' strategic behavior

International Nuclear Information System (INIS)

Teixeira Carneiro, J.M.; Ferreira Deschamps Cavalcanti, M.A.; Dos Santos, E.M.

1999-01-01

This is the second article of a series whose objective is to use the analytical framework proposed by Michael Porter, from the University of Harvard, to study the global oil competition game and the competitive advantages of oil companies. The paper focuses on the historical changes in the positioning and behavior of various actors in the upstream oil industry. The authors start by describing the main oil actors and their initial strategic positioning before 1973. Then, the changes and the firm's strategic repositioning during the oil crisis in the 1970's and 1980's are analyzed. (author)

An Energy Efficient Simultaneous-Node Repositioning Algorithm for Mobile Sensor Networks

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Hasbullah, Halabi; Nazir, Babar; Khan, Imran Ali

2014-01-01

Recently, wireless sensor network (WSN) applications have seen an increase in interest. In search and rescue, battlefield reconnaissance, and some other such applications, so that a survey of the area of interest can be made collectively, a set of mobile nodes is deployed. Keeping the network nodes connected is vital for WSNs to be effective. The provision of connectivity can be made at the time of startup and can be maintained by carefully coordinating the nodes when they move. However, if a node suddenly fails, the network could be partitioned to cause communication problems. Recently, several methods that use the relocation of nodes for connectivity restoration have been proposed. However, these methods have the tendency to not consider the potential coverage loss in some locations. This paper addresses the concerns of both connectivity and coverage in an integrated way so that this gap can be filled. A novel algorithm for simultaneous-node repositioning is introduced. In this approach, each neighbour of the failed node, one by one, moves in for a certain amount of time to take the place of the failed node, after which it returns to its original location in the network. The effectiveness of this algorithm has been verified by the simulation results. PMID:25152924

Field programmable gate array based hardware implementation of a gradient filter for edge detection in colour images with subpixel precision

International Nuclear Information System (INIS)

Schellhorn, M; Rosenberger, M; Correns, M; Blau, M; Goepfert, A; Rueckwardt, M; Linss, G

2010-01-01

Within the field of industrial image processing the use of colour cameras becomes ever more common. Increasingly the established black and white cameras are replaced by economical single-chip colour cameras with Bayer pattern. The use of the additional colour information is particularly important for recognition or inspection. Become interesting however also for the geometric metrology, if measuring tasks can be solved more robust or more exactly. However only few suitable algorithms are available, in order to detect edges with the necessary precision. All attempts require however additional computation expenditure. On the basis of a new filter for edge detection in colour images with subpixel precision, the implementation on a pre-processing hardware platform is presented. Hardware implemented filters offer the advantage that they can be used easily with existing measuring software, since after the filtering a single channel image is present, which unites the information of all colour channels. Advanced field programmable gate arrays represent an ideal platform for the parallel processing of multiple channels. The effective implementation presupposes however a high programming expenditure. On the example of the colour filter implementation, arising problems are analyzed and the chosen solution method is presented.

Performance of a Novel Repositioning Head Frame for Gamma Knife Perfexion and Image-Guided Linac-Based Intracranial Stereotactic Radiotherapy

International Nuclear Information System (INIS)

Ruschin, Mark; Nayebi, Nazanin; Carlsson, Per; Brown, Kevin

2010-01-01

Purpose: To evaluate the geometric positioning and immobilization performance of a vacuum bite-block repositioning head frame (RHF) system for Perfexion (PFX-SRT) and linac-based intracranial image-guided stereotactic radiotherapy (SRT). Methods and Materials: Patients with intracranial tumors received linac-based image-guided SRT using the RHF for setup and immobilization. Three hundred thirty-three fractions of radiation were delivered in 12 patients. The accuracy of the RHF was estimated for linac-based SRT with online cone-beam CT (CBCT) and for PFX-SRT with a repositioning check tool (RCT) and offline CBCT. The RCT's ability to act as a surrogate for anatomic position was estimated through comparison to CBCT image matching. Immobilization performance was evaluated daily with pre- and postdose delivery CBCT scans and RCT measurements. Results: The correlation coefficient between RCT- and CBCT-reported displacements was 0.59, 0.75, 0.79 (Right, Superior, and Anterior, respectively). For image-guided linac-based SRT, the mean three-dimensional (3D) setup error was 0.8 mm with interpatient (Σ) and interfraction (σ) variations of 0.1 and 0.4 mm, respectively. For PFX-SRT, the initial, uncorrected mean 3D positioning displacement in stereotactic coordinates was 2.0 mm, with Σ = 1.1 mm and σ = 0.8 mm. Considering only RCT setups o in pitch. The mean 3D intrafraction motion was 0.4 ± 0.3 mm. Conclusion: The RHF provides excellent immobilization for intracranial SRT and PFX-SRT. Some small systematic uncertainties in stereotactic positioning exist and must be considered when generating PFX-SRT treatment plans. The RCT provides reasonable surrogacy for internal anatomic displacement.

Raziskovalni model strateškega repozicioniranja blagovne znamke = Research Model of Strategic Repositioning of the Brand

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Tina Vukasovič

2009-09-01

Full Text Available Development of the world food market has, in recent years, been markedby rapid, unexpected and complex changes. The world food industryis operating in an explicitly dynamic environment which demandsconstant adjustments and responses. Good familiarity with consumers,their habits, wishes, and motives for buying a certain product is becomingan increasingly important area and food companies have,therefore, devoted more attention to it. The paper uses case a studyof the brand Perutnina Ptuj to illustrate the importance of action elementsin repositioning a brand in competitive markets. The exampleis illustrated by using a research model of strategic repositioningof a brand. The results of the analysis of competitors, the analysis ofthe brand, the results of qualitative research, and the developmentand testing of possible concepts on international markets have offereda basic starting-point for a new positioning of the brand.

From Bench to Bedside: Attempt to Evaluate Repositioning of Drugs in the Treatment of Metastatic Small Cell Lung Cancer (SCLC)

Science.gov (United States)

Lohinai, Zoltan; Dome, Peter; Szilagyi, Zsuzsa; Ostoros, Gyula; Moldvay, Judit; Hegedus, Balazs

2016-01-01

Backgrounds Based on in vitro data and results of a recent drug repositioning study, some medications approved by the FDA for the treatment of various non-malignant disorders were demonstrated to have anti-SCLC activity in preclinical models. The aim of our study is to confirm whether use of these medications is associated with survival benefit. Methods Consecutive patients with pathologically confirmed, stage 4 SCLC were analyzed in this retrospective study. Patients that were prescribed statins, aspirin, clomipramine (tricyclic antidepressant; TCA), selective serotonin reuptake inhibitors (SSRIs), doxazosin or prazosin (α1-adrenergic receptor antagonists; ADRA1) were identified. Results There were a total of 876 patients. Aspirin, statins, SSRIs, ADRA1, and TCA were administered in 138, 72, 20, 28, and 5 cases, respectively. A statistically significant increase in median OS was observed only in statin-treated patients when compared to those not receiving any of the aforementioned medications (OS, 8.4 vs. 6.1 months, respectively; p = 0.002). The administration of SSRIs, aspirin, and ADRA1 did not result in a statistically significant OS benefit (median OS, 8.5, 6.8, and 6.0 months, respectively). The multivariate Cox model showed that, besides age and ECOG PS, radiotherapy was an independent survival predictor (Hazard Ratio, 2.151; 95% confidence interval, 1.828–2.525; p <0.001). Conclusions Results of drug repositioning studies using only preclinical data or small numbers of patients should be treated with caution before application in the clinic. Our data demonstrated that radiotherapy appears to be an independent survival predictor in stage 4 SCLC, therefore confirming the results of other prospective and retrospective studies. PMID:26735301

From Bench to Bedside: Attempt to Evaluate Repositioning of Drugs in the Treatment of Metastatic Small Cell Lung Cancer (SCLC.

Directory of Open Access Journals (Sweden)

Zoltan Lohinai

Full Text Available Based on in vitro data and results of a recent drug repositioning study, some medications approved by the FDA for the treatment of various non-malignant disorders were demonstrated to have anti-SCLC activity in preclinical models. The aim of our study is to confirm whether use of these medications is associated with survival benefit.Consecutive patients with pathologically confirmed, stage 4 SCLC were analyzed in this retrospective study. Patients that were prescribed statins, aspirin, clomipramine (tricyclic antidepressant; TCA, selective serotonin reuptake inhibitors (SSRIs, doxazosin or prazosin (α1-adrenergic receptor antagonists; ADRA1 were identified.There were a total of 876 patients. Aspirin, statins, SSRIs, ADRA1, and TCA were administered in 138, 72, 20, 28, and 5 cases, respectively. A statistically significant increase in median OS was observed only in statin-treated patients when compared to those not receiving any of the aforementioned medications (OS, 8.4 vs. 6.1 months, respectively; p = 0.002. The administration of SSRIs, aspirin, and ADRA1 did not result in a statistically significant OS benefit (median OS, 8.5, 6.8, and 6.0 months, respectively. The multivariate Cox model showed that, besides age and ECOG PS, radiotherapy was an independent survival predictor (Hazard Ratio, 2.151; 95% confidence interval, 1.828-2.525; p <0.001.Results of drug repositioning studies using only preclinical data or small numbers of patients should be treated with caution before application in the clinic. Our data demonstrated that radiotherapy appears to be an independent survival predictor in stage 4 SCLC, therefore confirming the results of other prospective and retrospective studies.

THE MANAGEMENT OF LIMITED MANDIBULAR MOVEMENT CAUSED BY CONDYLAR FRACTURE WITH REPOSITIONING SPLINT

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Ira Tanti

2015-06-01

Full Text Available Fractures of the neck of condyle usually are the result of a blow to the mandible. A lateral blow to the body of the mandible commonly causes a contralateral condyle fracture. There are many signs and symptoms of a condylar fracture, for example crepitation, deviation of the mandible to the side of injury, and spasm of the associated group of muscles. These will result in a functional disability, which is usually seen as a limited mandibular movement. This paper reported a patient with a fracture of the condylar neck. Patient had been treated with closed reduction and immobilization for 2 months. After that, she felt that her bite was changed, she could not occlude her teeth well, and she had clicking sound in the right joint when she opened her mouth. Besides that, patient had difficulties to move the mandible to the left side, and she could not open her mouth widely. The patient was treated with a repositioning splint and she had to do some jaw exercises. The purposes were to regain the position of condyle, to reduce the muscle spasm and finally got the normal jaw movement.

Tubular foreign body or stent: safe retrieval or repositioning using the coaxial snare technique

International Nuclear Information System (INIS)

Seong, Chang Kyu; Kim, Yong Joo; Chung, Jin Wook; Kim, Seung Hyup; Han, Joon Koo; Kim, Hyun Beom; Park, Jae Hyung

2002-01-01

To evaluate the utility and advantages of the coaxial snare technique in the retrieval of tubular foreign bodies. Using the coaxial snare technique, we attempted to retrieve tubular foreign bodies present in seven patients. The bodies were either stents which were malpositioned or had migrated from their correct position in the vascular system (n=2), a fragmented venous introducer sheath (n=1), fragmented drainage catheters in the biliary tree (n=2), or fractured external drainage catheters in the urinary tract (n=2). After passing a guidewire and/or a dilator through the lumina of these foreign bodies, we introduced a loop snare over the guidewire or dilator, thus capturing and retrieving them. In all cases, it was possible to retrieve or reposition the various items, using a minimum-sized introducer sheath or a tract. No folding was involved. In no case were surgical procedures required, and no complications were encountered. The coaxial snare technique, an application of the loop snare technique, is a useful and safe method for the retrieval of tubular foreign bodies, and one which involves minimal injury to the patient

Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions.

Science.gov (United States)

Vazquez-Martin, Alejandro; López-Bonetc, Eugeni; Cufí, Sílvia; Oliveras-Ferraros, Cristina; Del Barco, Sonia; Martin-Castillo, Begoña; Menendez, Javier A

2011-01-01

Ideal oncology drugs would be curative after a short treatment course if they could eliminate epithelium-originated carcinomas at their non-invasive, pre-malignant stages. Such ideal molecules, which are expected to molecularly abrogate all the instrumental mechanisms acquired by migrating cancer stem cells (CSCs) to by-pass tumour suppressor barriers, might already exist. We here illustrate how system biology strategies for repositioning existing FDA-approved drugs may accelerate our therapeutic capacity to eliminate CSC traits in pre-invasive intraepithelial neoplasias. First, we describe a signalling network signature that overrides bioenergetics stress- and oncogene-induced senescence (OIS) phenomena in CSCs residing at pre-invasive lesions. Second, we functionally map the anti-malarial chloroquine and the anti-diabetic metformin ("old drugs") to their recently recognized CSC targets ("new uses") within the network. By discussing the preclinical efficacy of chloroquine and metformin to inhibiting the genesis and self-renewal of CSCs we finally underscore the expected translational impact of the "old drugs-new uses" repurposing strategy to open a new CSC-targeted chemoprevention era. Copyright © 2011 Elsevier Ltd. All rights reserved.

MLC quality assurance using EPID: A fitting technique with subpixel precision

International Nuclear Information System (INIS)

Mamalui-Hunter, Maria; Li, Harold; Low, Daniel A.

2008-01-01

Amorphous silicon based electronic portal imaging devices (EPIDs) have been shown to be a good alternative to radiographic film for routine quality assurance (QA) of multileaf collimator (MLC) positioning accuracy. In this work, we present a method of acquiring an EPID image of a traditional strip-test image using analytical fits of the interleaf and leaf abutment image signatures. After exposure, the EPID image pixel values are divided by an open field image to remove EPID response and radiation field variations. Profiles acquired in the direction orthogonal to the leaf motion exhibit small peaks caused by interleaf leakage. Gaussian profiles are fitted to the interleaf leakage peaks, the results of which are, using multiobjective optimization, used to calculate the image rotational angle with respect to the collimator axis of rotation. The relative angle is used to rotate the image to align the MLC leaf travel to the image pixel axes. The leaf abutments also present peaks that are fitted by heuristic functions, in this case modified Lorentzian functions. The parameters of the Lorentzian functions are used to parameterize the leaf gap width and positions. By imaging a set of MLC fields with varying gaps forming symmetric and asymmetric abutments, calibration curves with regard to relative peak height (RPH) versus nominal gap width are obtained. Based on this calibration data, the individual leaf positions are calculated to compare with the nominal programmed positions. The results demonstrate that the collimator rotation angle can be determined as accurate as 0.01 deg. . A change in MLC gap width of 0.2 mm leads to a change in RPH of about 10%. For asymmetrically produced gaps, a 0.2 mm MLC leaf gap width change causes 0.2 pixel peak position change. Subpixel resolution is obtained by using a parameterized fit of the relatively large abutment peaks. By contrast, for symmetrical gap changes, the peak position remains unchanged with a standard deviation of 0

Whole-body MRI using a sliding table and repositioning surface coil approach

International Nuclear Information System (INIS)

Takahara, Taro; Kwee, Thomas; Luijten, Peter; Kibune, Satoshi; Ochiai, Reiji; Sakamoto, Tetsuro; Niwa, Tetsu; Van Cauteren, Marc

2010-01-01

To introduce and assess a new way of performing whole-body magnetic resonance imaging (MRI) using a non-integrated surface coil approach as available on most clinical MRI systems worldwide. Ten consecutive asymptomatic subjects prospectively underwent whole-body MRI for health screening. Whole-body MRI included T1-, T2- and diffusion-weighted sequences, and was performed using a non-integrated surface coil to image four different stations without patient repositioning. The four separately acquired stations were merged, creating seamless coronal whole-body T1-, T2- and diffusion-weighted images. Anatomical alignment, image quality at the boundaries of adjacent stations, and overall image quality of all stations were qualitatively assessed. The average time (±SD) taken to change the surface coil from one station to the next station was 53.8 (±7.1) s. The average total extra examination time ± SD was 2 min 41.4 s (±15.3 s). Anatomical alignment, image quality at the boundaries of adjacent stations, and overall image quality of all stations of T1-, T2- and diffusion-weighted whole-body MRI were overall graded as ''good'' to ''excellent''. This study shows that a time-efficient and high-quality whole-body MRI examination can easily be performed by using a non-integrated sliding surface coil approach. (orig.)

Reposicionamento de Marcas: estudo de casos brasileirosBrands Repositioning: Brazilian case studiesReposicionamiento de Marcas: estudio de casos brasileños

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FURRIER, Marcio Tadeu

2008-03-01

Full Text Available RESUMOEste trabalho teve por objetivo aprofundar o conhecimento existente sobre o processo de reposicionamento de marcas, partindo da premissa da relevância crescente do posicionamento e do patrimônio da marca no contexto da gestão do marketing em ambientes competitivos. A verificação empírica constou da análise de seis relatos (casos de reposicionamento de marcas brasileiras vencedoras do Prêmio Top de Marketing das edições de 1999 a 2003, com o emprego da metodologia da análise de conteúdo, tomando por base a estrutura de quatro referenciais teóricos, obtidos na revisão da literatura pertinente. Este texto conclui pela existência de três blocos constituintes de um programa de reposicionamento, formados pelas fases de diagnóstico, decisão e implantação, predominando os dois primeiros nos modelos teóricos, enquanto nas experiências verificadas (casos a fase de implantação foi dominante.ABSTRACTBased on the assumption of the increasing relevance of both brand positioning and equity in the context of marketing management in competitive environments, the objective of this work was to deepen the existing knowledge on the brand repositioning process. Four theoretical models of reference obtained after literature review supported the empiric verification represented by content analysis of six reports (cases of Brazilian brands repositioning experiences awarded with the “Top of Marketing” prize in the period 1999-2003. Results conclude for the existence of three constituent blocks of a repositioning program, formed for the phases of diagnosis, decision and implementation, with the predomination of the two first ones in the theoretical models, while in the practical experiences the implementation phase was dominant.RESUMENEl trabajo tuvo por finalidad profundizar el conocimiento existente sobre el proceso de reposicionamiento de marcas, considerando como premisa la creciente relevancia del posicionamiento y del valor de la

Solving intraocular lens-related pigment dispersion syndrome with repositioning of primary sulcus implanted single-piece IOL in the capsular bag.

Science.gov (United States)

Kohnen, Thomas; Kook, Daniel

2009-08-01

We describe 2 cases of pigment dispersion syndrome (PDS) after uneventful phacoemulsification and implantation of a posterior chamber single-piece intraocular lens (IOL) with a sharp-edge design. In both cases, several days after IOL implantation, marked pigment dispersion was seen on the iris and in the trabecular meshwork, associated with an elevation in intraocular pressure (IOP). Thorough examination showed that the implanted IOL was in the ciliary sulcus. After surgical repositioning of both IOLs in the capsular bag, the pigment dispersion regressed and the IOP returned to normal limits. The 2 cases suggest that particularly in PDS patients, an IOL with an anterior sharp-edge design should be implanted in the capsular bag. Implantation in the ciliary sulcus should be avoided.

Development of a Standardized Methodology for the Use of COSI-Corr Sub-Pixel Image Correlation to Determine Surface Deformation Patterns in Large Magnitude Earthquakes.

Science.gov (United States)

Milliner, C. W. D.; Dolan, J. F.; Hollingsworth, J.; Leprince, S.; Ayoub, F.

2014-12-01

Coseismic surface deformation is typically measured in the field by geologists and with a range of geophysical methods such as InSAR, LiDAR and GPS. Current methods, however, either fail to capture the near-field coseismic surface deformation pattern where vital information is needed, or lack pre-event data. We develop a standardized and reproducible methodology to fully constrain the surface, near-field, coseismic deformation pattern in high resolution using aerial photography. We apply our methodology using the program COSI-corr to successfully cross-correlate pairs of aerial, optical imagery before and after the 1992, Mw 7.3 Landers and 1999, Mw 7.1 Hector Mine earthquakes. This technique allows measurement of the coseismic slip distribution and magnitude and width of off-fault deformation with sub-pixel precision. This technique can be applied in a cost effective manner for recent and historic earthquakes using archive aerial imagery. We also use synthetic tests to constrain and correct for the bias imposed on the result due to use of a sliding window during correlation. Correcting for artificial smearing of the tectonic signal allows us to robustly measure the fault zone width along a surface rupture. Furthermore, the synthetic tests have constrained for the first time the measurement precision and accuracy of estimated fault displacements and fault-zone width. Our methodology provides the unique ability to robustly understand the kinematics of surface faulting while at the same time accounting for both off-fault deformation and measurement biases that typically complicates such data. For both earthquakes we find that our displacement measurements derived from cross-correlation are systematically larger than the field displacement measurements, indicating the presence of off-fault deformation. We show that the Landers and Hector Mine earthquake accommodated 46% and 38% of displacement away from the main primary rupture as off-fault deformation, over a mean

Preprints na comunicação científica da Física de Altas Energias: análise das submissões no repositório arXiv (2010-2015

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Gonzalo Rubén Alvarez

Full Text Available RESUMO A circulação de preprints na Física de Altas Energias (FAE remonta a mais de meio século, tendo como objetivos principais acelerar o processo de comunicação científica entre os pares e estimular o acesso livre à literatura especializada da área. O artigo analisa o conjunto de preprints submetidos às diferentes categorias FAE do repositório temático especializado arXiv no período 2010-2015 que foram posteriormente publicados em revistas peer review. Os indicadores bibliométricos demonstram a potencialidade dos preprints como canal precursor de difusão de resultados científicos visto que 70% das submissões foram em seguida absorvidas pelas principais revistas da FAE. Conclui que o êxito alcançado pelas iniciativas Open Access arXiv e INSPIRE-HEP favoreceu o intercâmbio de informações e conhecimentos entre os pesquisadores. O modelo proposto pela FAE pode incentivar cientistas de áreas com características similares a instalarem repositórios e bancos de dados de preprints para suas disciplinas com o intuito de fortalecer a comunicação das descobertas científicas.

NEGOTIATION OF IDENTITY: (RECONSTRUCTION AND (REPOSITIONING OF SELF THROUGH LANGUAGE LEARNING

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Naho Isiki

2013-07-01

Full Text Available Abstract: Becoming competent in a language involves more than just academic success, but also multi-faceted aspects of self in a situated context. The core of the study is to explore a participant’s experience as a marginalized student in a Filipino American community and the trajectories of learning a foreign language over time and space. Narratives from the participant reflect his approach toward language learning (LL as well as his motivation behind language learning. This study highlights the impact of foreign language learning experience upon the participant’s conflict, negotiation, and transformation of identity. Following his positioning analysis, the paper closely looks at how evaluation by other Filipinos within the community contributes to the participant’s ongoing (reconstruction and negotiation of identity. How these evaluations encourage or impede his access to heritage language and culture is analyzed based on the participant’s use of reported speech. The paper explored whether or not LL can be a way of negotiating and gaining agency, as well as how LL helps a marginalized learner to choose where and how he wants to belong to. The paper also looks at how marginalization motivates language learning, through which the participant seeks to reposition himself. The study also examines how power relationship (marginalized student in a situated context plays a role in the process of negotiation of identity and meaning-making of self. Results from this study conclude that through experiences in foreign language learning as well as negotiating meanings for being a Japanese as a Foreign Language (JFL student, the participant gradually shifts to belong to a different community prior to his language learning experience in which he can practice agency and is no longer a marginalized member of his heritage community.

Repositioning the Racial Gaze: Aboriginal Perspectives on Race, Race Relations and Governance

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Daphne Habibis

2016-02-01

Full Text Available In Australia, public debate about recognition of the nation’s First Australians through constitutional change has highlighted the complexity and sensitivities surrounding Indigenous/state relations at even the most basic level of legal rights. But the unevenness of race relations has meant Aboriginal perspectives on race relations are not well known. This is an obstacle for reconciliation which, by definition, must be a reciprocal process. It is especially problematic in regions with substantial Aboriginal populations, where Indigenous visibility make race relations a matter of everyday experience and discussion. There has been considerable research on how settler Australians view Aboriginal people but little is known about how Aboriginal people view settler Australians or mainstream institutions. This paper presents the findings from an Australian Research Council project undertaken in partnership with Larrakia Nation Aboriginal Corporation. Drawing on in-depth interviews with a cross-section of Darwin’s Aboriginal residents and visitors, it aims to reverse the racial gaze by investigating how respondents view settler Australian politics, values, priorities and lifestyles. Through interviews with Aboriginal people this research provides a basis for settler Australians to discover how they are viewed from an Aboriginal perspective. It repositions the normativity of settler Australian culture, a prerequisite for a truly multicultural society. Our analysis argues the narratives of the participants produce a story of Aboriginal rejection of the White Australian neo-liberal deal of individual advancement through economic pathways of employment and hyper-consumption. The findings support Honneth’s arguments about the importance of intersubjective recognition by pointing to the way misrecognition creates and reinforces social exclusion.

Reposição cirúrgico-ortopédica de implante mal posicionado: relato de caso Surgical-orthopedic repositioning of malpositioned implant: a case report

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Luiz Carlos Ferreira da Silva

2005-06-01

Full Text Available A reabilitação bucal por meio da colocação de implantes dentários tem se tornado um procedimento freqüente da clínica odontológica. Falhas no planejamento ou na execução da técnica podem levar a casos onde, apesar de osseointegrado, o implante não apresenta condições de restauração satisfatória devido ao seu mal posicionamento. Diversos autores têm relatado a possibilidade de se utilizar osteotomias segmentares de maxila ou mandíbula para reposicionar um segmento alveolar com implante, mostrando que esta pode ser uma técnica efetiva e previsível para restaurar implantes em posição anatômica comprometida. O presente trabalho apresenta o caso clínico de uma paciente de 20 anos de idade onde foi realizada osteotomia segmentar de maxila associada à distração osteogênica para correção de um implante mal posicionado.Oral rehabilitation through dental implants has become a common procedure at dental practice. However, if the implant is placed in an inappropriate position either because of inadequate presurgical planning or poor surgical technique, it may be unrestorable in spite of osseointegrated. Many authors have reported the possibility of using segmental maxillary or mandibular osteotomies to reposition an alveolar segment with its implants. This can be an effective, predictable technique for restoring implants in a compromised anatomic position. This paper presents a case report describing the use of this procedure associated to distraction osteogeneis to reposition one malpositioned implant in a 20 years old girl.

The impact of diabetes on mobility, balance, and recovery after repositioning maneuvers in individuals with benign paroxysmal positional vertigo.

Science.gov (United States)

D'Silva, Linda J; Whitney, Susan L; Santos, Marcio; Dai, Hongying; Kluding, Patricia M

2017-06-01

The prevalence of benign paroxysmal positional vertigo (BPPV) is higher in people with type 2 diabetes (DM). The impact of DM on mobility, balance, and management of BPPV is unknown. This prospective study compared symptom severity, mobility and balance before and after the canalith repositioning maneuver (CRM) in people with posterior canal BPPV canalithiasis, with and without DM. Fifty participants, BPPV (n=34) and BPPV+DM (n=16) were examined for symptom severity (dizziness handicap inventory, DHI), mobility (functional gait assessment, FGA), and postural sway (using an accelerometer in five conditions) before and after the CRM. The number of maneuvers required for symptom resolution was recorded. At baseline, no differences in DHI or FGA scores were seen between groups, however, people with BPPV+DM had higher sway velocity in the medio-lateral direction in tandem stance (pdiabetes, as well as the influence of diabetic peripheral neuropathy on functional performance are essential. Copyright © 2017 Elsevier Inc. All rights reserved.

Ultrasonic propulsion of kidney stones.

Science.gov (United States)

May, Philip C; Bailey, Michael R; Harper, Jonathan D

2016-05-01

Ultrasonic propulsion is a novel technique that uses short bursts of focused ultrasonic pulses to reposition stones transcutaneously within the renal collecting system and ureter. The purpose of this review is to discuss the initial testing of effectiveness and safety, directions for refinement of technique and technology, and opinions on clinical application. Preclinical studies with a range of probes, interfaces, and outputs have demonstrated feasibility and consistent safety of ultrasonic propulsion with room for increased outputs and refinement toward specific applications. Ultrasonic propulsion was used painlessly and without adverse events to reposition stones in 14 of 15 human study participants without restrictions on patient size, stone size, or stone location. The initial feasibility study showed applicability in a range of clinically relevant situations, including facilitating passage of residual fragments following ureteroscopy or shock wave lithotripsy, moving a large stone at the ureteropelvic junction with relief of pain, and differentiating large stones from a collection of small fragments. Ultrasonic propulsion shows promise as an office-based system for transcutaneously repositioning kidney stones. Potential applications include facilitating expulsion of residual fragments following ureteroscopy or shock wave lithotripsy, repositioning stones prior to treatment, and repositioning obstructing ureteropelvic junction stones into the kidney to alleviate acute renal colic.

Alveolar nerve repositioning with rescue implants for management of previous treatment. A clinical report.

Science.gov (United States)

Amet, Edward M; Uehlein, Chris

2013-12-01

The goal of modern implant dentistry is to return patients to oral health in a rapid and predictable fashion, following a diagnostically driven treatment plan. If only a limited number of implants can be placed, or some fail and the prosthetic phase of implant dentistry is chosen to complete the patient's treatment, the final outcome may result in partial patient satisfaction and is commonly referred to as a "compromise." Previous All-on-4 implant treatment for the patient presented here resulted in a compromise, with an inadequate support system for the mandibular prosthesis and a maxillary complete denture with poor esthetics. The patient was unable to function adequately and also was disappointed with the resulting appearance. Correction of the compromised treatment consisted of bilateral inferior alveolar nerve elevation and repositioning without bone removal for lateral transposition, to gain room for rescue implants for a totally implant-supported and stabilized prosthesis. Treatment time to return the patient to satisfactory comfort, function, facial esthetics, and speech was approximately 2 weeks. The definitive mandibular prosthesis was designed for total implant support and stability with patient retrievability. Adequate space between the mandibular bar system and the soft tissue created a high water bridge effect for self-cleansing. Following a short interim mandibular healing period, the maxillary sinuses were bilaterally grafted to compensate for bone inadequacies and deficiencies for future maxillary implant reconstruction. © 2013 by the American College of Prosthodontists.

Identifying prognostic features by bottom-up approach and correlating to drug repositioning.

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Wei Li

Full Text Available Traditionally top-down method was used to identify prognostic features in cancer research. That is to say, differentially expressed genes usually in cancer versus normal were identified to see if they possess survival prediction power. The problem is that prognostic features identified from one set of patient samples can rarely be transferred to other datasets. We apply bottom-up approach in this study: survival correlated or clinical stage correlated genes were selected first and prioritized by their network topology additionally, then a small set of features can be used as a prognostic signature.Gene expression profiles of a cohort of 221 hepatocellular carcinoma (HCC patients were used as a training set, 'bottom-up' approach was applied to discover gene-expression signatures associated with survival in both tumor and adjacent non-tumor tissues, and compared with 'top-down' approach. The results were validated in a second cohort of 82 patients which was used as a testing set.Two sets of gene signatures separately identified in tumor and adjacent non-tumor tissues by bottom-up approach were developed in the training cohort. These two signatures were associated with overall survival times of HCC patients and the robustness of each was validated in the testing set, and each predictive performance was better than gene expression signatures reported previously. Moreover, genes in these two prognosis signature gave some indications for drug-repositioning on HCC. Some approved drugs targeting these markers have the alternative indications on hepatocellular carcinoma.Using the bottom-up approach, we have developed two prognostic gene signatures with a limited number of genes that associated with overall survival times of patients with HCC. Furthermore, prognostic markers in these two signatures have the potential to be therapeutic targets.

A novel balloon assisted two-stents telescoping technique for repositioning an embolized stent in the pulmonary conduit.

Science.gov (United States)

Kobayashi, Daisuke; Gowda, Srinath T; Forbes, Thomas J

2014-08-01

A 9-year-old male, with history of pulmonary atresia and ventricular septal defect, status post complete repair with a 16 mm pulmonary homograft in the right ventricular outflow tract (RVOT) underwent 3110 Palmaz stent placement for conduit stenosis. Following deployment the stent embolized proximally into the right ventricle (RV). We undertook the choice of repositioning the embolized stent into the conduit with a transcatheter approach. Using a second venous access, the embolized stent was carefully maneuvered into the proximal part of conduit with an inflated Tyshak balloon catheter. A second Palmaz 4010 stent was deployed in the distal conduit telescoping through the embolized stent. The Tyshak balloon catheter was kept inflated in the RV to stabilize the embolized stent in the proximal conduit until it was successfully latched up against the conduit with the deployment of the overlapping second stent. One year later, he underwent Melody valve implantation in the pre-stented conduit relieving conduit insufficiency. This novel balloon assisted two-stents telescoping technique is a feasible transcatheter option to secure an embolized stent from the RV to the RVOT. © 2014 Wiley Periodicals, Inc.

Manobras de reposicionamento no tratamento da vertigem paroxística posicional benigna Treatment of benign paroxysmal positional vertigo with repositioning manevers

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Roberto A. Maia

2001-09-01

Full Text Available Introdução: Vertigem paroxística posicional benigna (VPPB é uma das mais freqüentes patologias do sistema vestibular. Caracteriza-se clinicamente pela presença de episódios recorrentes de tonturas rotatórias, tipicamente desencadeados por determinados movimentos cefálicos, realizados pelo paciente. A confirmação diagnóstica é obtida exclusivamente pela manobra de Dix-Hallpike. Nessa manobra, observa-se sistematicamente o desencadeamento de nistagmo. Forma de estudo: Prospectivo clínico não randomizado. Material e método: No total, sete pacientes com diagnóstico clínico de VPPB são submetidos a tratamento pela manobra de reposicionamento de Epley. Resultado: Desses sete pacientes avaliados, cinco apresentaram ótima recuperação; dois, com resultado bom; e um, com mau resultado; para este último caso, outras formas de tratamento são apresentadas. Conclusão: O exame otoneurológico, realizado em todos os pacientes, demonstrou ser de interessante valor prognóstico quanto ao resultado do tratamento proposto. A manobra de reposicionamento de Epley demonstrou ser um método de tratamento da VPPB simples, e eficaz na grande maioria dos pacientes aqui relatados.Introduction: Benign Paroxysmal Positional Vertigo (BPPV is among the most common vestibular disorders. It is characterized by recurrent episodes of vertigo induced by changes in head position. The condition is readly diagnosed by performing the Dix-Hallpike maneuver. Nystagmus is always present by this way. Study design: Prospective results clinical not randomized. Material and method: A total of seven patients diagnosed with BPPV received the repositioning maneuver of Epley. Five out of seven patients had excellent recovery, two patients had good results and one had a bad result. For this last one different treatments are discussed. Conclusion: We performed otoneurological examination in all patients; this test seems to be an intersting prognosis method for seeking the

Restoring facial shape in face lifting: the role of skeletal support in facial analysis and midface soft-tissue repositioning.

Science.gov (United States)

Stuzin, James M

2007-01-01

Aesthetic analysis in facial rejuvenation has traditionally been subordinate to technical solutions. While concerns regarding correction of facial laxity, a reduction in the depth of the nasolabial fold, and improvement of both the jowl and the jawline are worthy goals in rhytidectomy, the aesthetic concept of restoring facial shape to a more youthful appearance is equally important. Restoring facial shape in face lifting requires an understanding of how the face ages and then the formulation of a treatment plan that is individualized for the patient. Re-establishment of facial contour is significantly influenced by the re-elevation of descended facial fat through superficial musculoaponeurotic system manipulation; it can be approached through a variety of technical solutions. Underlying skeletal support affects not only the appearance of the face in youth but also how the face ages and influences the operative plan in terms of the requirements for fat repositioning. Formulating a treatment plan that is patient specific and based on the artistic goals as influenced by skeletal support is the key element for consistency in restoring facial shape in face lifting.

Remote sensing estimates of impervious surfaces for hydrological modelling of changes in flood risk during high-intensity rainfall events

DEFF Research Database (Denmark)

Kaspersen, Per Skougaard; Fensholt, Rasmus; Drews, Martin

This paper addresses the accuracy and applicability of medium resolution (MR) remote sensing estimates of impervious surfaces (IS) for urban land cover change analysis. Landsat-based vegetation indices (VI) are found to provide fairly accurate measurements of sub-pixel imperviousness for urban...... areas at different geographical locations within Europe, and to be applicable for cities with diverse morphologies and dissimilar climatic and vegetative conditions. Detailed data on urban land cover changes can be used to examine the diverse environmental impacts of past and present urbanisation...

Reflective photovoltaics

Energy Technology Data Exchange (ETDEWEB)

Lentine, Anthony L.; Nielson, Gregory N.; Cruz-Campa, Jose Luis; Okandan, Murat; Goeke, Ronald S.

2018-03-06

A photovoltaic module includes colorized reflective photovoltaic cells that act as pixels. The colorized reflective photovoltaic cells are arranged so that reflections from the photovoltaic cells or pixels visually combine into an image on the photovoltaic module. The colorized photovoltaic cell or pixel is composed of a set of 100 to 256 base color sub-pixel reflective segments or sub-pixels. The color of each pixel is determined by the combination of base color sub-pixels forming the pixel. As a result, each pixel can have a wide variety of colors using a set of base colors, which are created, from sub-pixel reflective segments having standard film thicknesses.

Anterior maxillary osteotomy: A technical note for superior repositioning: A bird wing segment

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V Sadesh Kannan

2014-01-01

Full Text Available Aim: The aim of this study is to evaluate the efficacy of a single piece bird wing osteotectomy segment during anterior maxillary osteotomy (AMO markedly reduces the duration of the surgery by nearly one-half of the time during bone removal with the conventional method thereby reducing the kinking effect to the palatal pedicle and gives good perfusion to the anterior segment. Materials and Methods: This study was conducted at Karpaga Vinayaga Institute of Dental Sciences composing of 20 patients in which male: female ratio was 8:12, with a mean age of 25-30 years. This bird wing segment technique is performed following presurgical orthodontics under the guidance of clinical assessment of the gummy smile with an incisal show when the lip is at repose (vertical maxillary excess, especially for the calculated amount of superior repositioning. It is calculated by subtracting 2 mm from the total amount of an incisor show when the lip is at repose. The normal incisal show when the lip is at repose is 2 mm. After conventional primary AMO cut was performed, the precise calculated. Results: All our cases were tested positive for pulp vitality, no relapse, and minimal edema and with no changes in the bite or dentoalveolar relation followed until 1 year postoperatively indicating a good perfusion to the anterior segment and all the patients were satisfied esthetically and free of complaints. Conclusion: This simple technique allows the precise amount of calculated bone removal in a single piece from the nasal floor markedly reduces the duration of the surgery by nearly one-half of the time during bone removal with the conventional method there by reducing the kinking effect to the palatal pedicle and maintains good perfusion.

The effect of split pixel HDR image sensor technology on MTF measurements

Science.gov (United States)

Deegan, Brian M.

2014-03-01

Split-pixel HDR sensor technology is particularly advantageous in automotive applications, because the images are captured simultaneously rather than sequentially, thereby reducing motion blur. However, split pixel technology introduces artifacts in MTF measurement. To achieve a HDR image, raw images are captured from both large and small sub-pixels, and combined to make the HDR output. In some cases, a large sub-pixel is used for long exposure captures, and a small sub-pixel for short exposures, to extend the dynamic range. The relative size of the photosensitive area of the pixel (fill factor) plays a very significant role in the output MTF measurement. Given an identical scene, the MTF will be significantly different, depending on whether you use the large or small sub-pixels i.e. a smaller fill factor (e.g. in the short exposure sub-pixel) will result in higher MTF scores, but significantly greater aliasing. Simulations of split-pixel sensors revealed that, when raw images from both sub-pixels are combined, there is a significant difference in rising edge (i.e. black-to-white transition) and falling edge (white-to-black) reproduction. Experimental results showed a difference of ~50% in measured MTF50 between the falling and rising edges of a slanted edge test chart.

A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions.

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Francesco Iorio

Full Text Available We present a novel strategy to identify drug-repositioning opportunities. The starting point of our method is the generation of a signature summarising the consensual transcriptional response of multiple human cell lines to a compound of interest (namely the seed compound. This signature can be derived from data in existing databases, such as the connectivity-map, and it is used at first instance to query a network interlinking all the connectivity-map compounds, based on the similarity of their transcriptional responses. This provides a drug neighbourhood, composed of compounds predicted to share some effects with the seed one. The original signature is then refined by systematically reducing its overlap with the transcriptional responses induced by drugs in this neighbourhood that are known to share a secondary effect with the seed compound. Finally, the drug network is queried again with the resulting refined signatures and the whole process is carried on for a number of iterations. Drugs in the final refined neighbourhood are then predicted to exert the principal mode of action of the seed compound. We illustrate our approach using paclitaxel (a microtubule stabilising agent as seed compound. Our method predicts that glipizide and splitomicin perturb microtubule function in human cells: a result that could not be obtained through standard signature matching methods. In agreement, we find that glipizide and splitomicin reduce interphase microtubule growth rates and transiently increase the percentage of mitotic cells-consistent with our prediction. Finally, we validated the refined signatures of paclitaxel response by mining a large drug screening dataset, showing that human cancer cell lines whose basal transcriptional profile is anti-correlated to them are significantly more sensitive to paclitaxel and docetaxel.

Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences.

Science.gov (United States)

Pilla, Giulia; McVicker, Gareth; Tang, Christoph M

2017-09-01

Acquisition of a single copy, large virulence plasmid, pINV, led to the emergence of Shigella spp. from Escherichia coli. The plasmid encodes a Type III secretion system (T3SS) on a 30 kb pathogenicity island (PAI), and is maintained in a bacterial population through a series of toxin:antitoxin (TA) systems which mediate post-segregational killing (PSK). The T3SS imposes a significant cost on the bacterium, and strains which have lost the plasmid and/or genes encoding the T3SS grow faster than wild-type strains in the laboratory, and fail to bind the indicator dye Congo Red (CR). Our aim was to define the molecular events in Shigella flexneri that cause loss of Type III secretion (T3S), and to examine whether TA systems exert positional effects on pINV. During growth at 37°C, we found that deletions of regions of the plasmid including the PAI lead to the emergence of CR-negative colonies; deletions occur through intra-molecular recombination events between insertion sequences (ISs) flanking the PAI. Furthermore, by repositioning MvpAT (which belongs to the VapBC family of TA systems) near the PAI, we demonstrate that the location of this TA system alters the rearrangements that lead to loss of T3S, indicating that MvpAT acts both globally (by reducing loss of pINV through PSK) as well as locally (by preventing loss of adjacent sequences). During growth at environmental temperatures, we show for the first time that pINV spontaneously integrates into different sites in the chromosome, and this is mediated by inter-molecular events involving IS1294. Integration leads to reduced PAI gene expression and impaired secretion through the T3SS, while excision of pINV from the chromosome restores T3SS function. Therefore, pINV integration provides a reversible mechanism for Shigella to circumvent the metabolic burden imposed by pINV. Intra- and inter-molecular events between ISs, which are abundant in Shigella spp., mediate plasticity of S. flexneri pINV.

Choice vs. voice? PPI policies and the re-positioning of the state in England and Wales.

Science.gov (United States)

Hughes, David; Mullen, Caroline; Vincent-Jones, Peter

2009-09-01

CONTEXT AND THESIS: Changing patient and public involvement (PPI) policies in England and Wales are analysed against the background of wider National Health Service (NHS) reforms and regulatory frameworks. We argue that the growing divergence of health policies is accompanied by a re-positioning of the state vis-à-vis PPI, characterized by different mixes of centralized and decentralized regulatory instruments. Analysis of legislation and official documents, and interviews with policy makers. In England, continued hierarchical control is combined with the delegation of responsibilities for the oversight and organization of PPI to external institutions such as the Care Quality Commission and local involvement networks, in support of the government's policy agenda of increasing marketization. In Wales, which has rejected market reforms and economic regulation, decentralization is occurring through the use of mixed regulatory approaches and networks suited to the small-country governance model, and seeks to benefit from the close proximity of central and local actors by creating new forms of engagement while maintaining central steering of service planning. Whereas English PPI policies have emerged in tandem with a pluralistic supply-side market and combine new institutional arrangements for patient 'choice' with other forms of involvement, the Welsh policies focus on 'voice' within a largely publicly-delivered service. While the English reforms draw on theories of economic regulation and the experience of independent regulation in the utilities sector, the Welsh model of local service integration has been more influenced by reforms in local government. Such transfers of governance instruments from other public service sectors to the NHS may be problematic.

Considerações acerca do processo de alimentação de repositórios através da importação de registros de bases de dados internacionaisConsiderations around of process of uploading repositories via import records of international data bases

Directory of Open Access Journals (Sweden)

Renan Carvalho Ramos

2012-06-01

Full Text Available Considerando que há um interesse global e crescente na implementação de repositórios institucionais e que as discussões em âmbito nacional sobre esse tema tem sido modestas, e que poucas são as iniciativas consolidadas no desenvolvimento desses sistemas nas universidades brasileiras, este trabalho toma como tema a questão da carga automática de registros comentada pelas diretrizes do programa intercontinental Alfa Biblioteca Babel. Para demonstrar as possibilidades e limitações da carga automática de registros referenciais a partir de bases de dados internacionais foi feito um estudo que se dividiu em quatro etapas, que se resumem em: escolha de um software para simular um repositório; análise de formatos de exportação dos metadados de algumas bases de dados disponíveis no Portal de Periódicos Capes; prospecção de registros e conversões de formato dos metadados; e alimentação do repositório através da importação dos registros coletados, indicando os efeitos desta prática. Como resultados são apontados um conjunto de ponderações a respeito do método que deve ser empregado para um melhor uso da carga automática de registros. Acredita-se que a carga automática de registros referenciais tem muito a colaborar com o início do desenvolvimento dos repositórios, à medida que oferece visibilidade à produção cientifica, favorecendo as instituições na elaboração dos índices de produção científica extraídos a partir dos emergentes estudos webmétricos, sem desrepeitar os principios de direitos do autor ou das editoras. Palavras-chave: Bases de dados internacionais. Carga automática de registros. Importação de registros. Repositórios institucionais. Software GreenStone Abstract Whereas there is a growing global interest in the implementation of institutional repositories and discussions in the national sphere about this issue have been modest, and there are few consolidated initiatives to develop these

Event-by-event jet quenching

Energy Technology Data Exchange (ETDEWEB)

Fries, R.J.; Rodriguez, R.; Ramirez, E.

2010-08-14

High momentum jets and hadrons can be used as probes for the quark gluon plasma (QGP) formed in nuclear collisions at high energies. We investigate the influence of fluctuations in the fireball on jet quenching observables by comparing propagation of light quarks and gluons through averaged, smooth QGP fireballs with event-by-event jet quenching using realistic inhomogeneous fireballs. We find that the transverse momentum and impact parameter dependence of the nuclear modification factor R{sub AA} can be fit well in an event-by-event quenching scenario within experimental errors. However the transport coefficient {cflx q} extracted from fits to the measured nuclear modification factor R{sub AA} in averaged fireballs underestimates the value from event-by-event calculations by up to 50%. On the other hand, after adjusting {cflx q} to fit R{sub AA} in the event-by-event analysis we find residual deviations in the azimuthal asymmetry v{sub 2} and in two-particle correlations, that provide a possible faint signature for a spatial tomography of the fireball. We discuss a correlation function that is a measure for spatial inhomogeneities in a collision and can be constrained from data.

Event-by-event jet quenching

Energy Technology Data Exchange (ETDEWEB)

Rodriguez, R. [Cyclotron Institute and Physics Department, Texas A and M University, College Station, TX 77843 (United States); Fries, R.J., E-mail: rjfries@comp.tamu.ed [Cyclotron Institute and Physics Department, Texas A and M University, College Station, TX 77843 (United States); RIKEN/BNL Research Center, Brookhaven National Laboratory, Upton, NY 11973 (United States); Ramirez, E. [Physics Department, University of Texas El Paso, El Paso, TX 79968 (United States)

2010-09-27

High momentum jets and hadrons can be used as probes for the quark gluon plasma (QGP) formed in nuclear collisions at high energies. We investigate the influence of fluctuations in the fireball on jet quenching observables by comparing propagation of light quarks and gluons through averaged, smooth QGP fireballs with event-by-event jet quenching using realistic inhomogeneous fireballs. We find that the transverse momentum and impact parameter dependence of the nuclear modification factor R{sub AA} can be fit well in an event-by-event quenching scenario within experimental errors. However the transport coefficient q extracted from fits to the measured nuclear modification factor R{sub AA} in averaged fireballs underestimates the value from event-by-event calculations by up to 50%. On the other hand, after adjusting q to fit R{sub AA} in the event-by-event analysis we find residual deviations in the azimuthal asymmetry v{sub 2} and in two-particle correlations, that provide a possible faint signature for a spatial tomography of the fireball. We discuss a correlation function that is a measure for spatial inhomogeneities in a collision and can be constrained from data.

Event Index - a LHCb Event Search System

CERN Document Server

INSPIRE-00392208; Kazeev, Nikita; Redkin, Artem

2015-12-23

LHC experiments generate up to $10^{12}$ events per year. This paper describes Event Index - an event search system. Event Index's primary function is quickly selecting subsets of events from a combination of conditions, such as the estimated decay channel or stripping lines output. Event Index is essentially Apache Lucene optimized for read-only indexes distributed over independent shards on independent nodes.

Maximizing signal-to-noise ratio (SNR) in 3-D large bandgap semiconductor pixelated detectors in optimal and non-optimal filtering conditions

International Nuclear Information System (INIS)

Rodrigues, Miesher L.; Serra, Andre da S.; He, Zhong; Zhu, Yuefeng

2009-01-01

3-D pixelated semiconductor detectors are used in radiation detection applications requiring spectroscopic and imaging information from radiation sources. Reconstruction algorithms used to determine direction and energy of incoming gamma rays can be improved by reducing electronic noise and using optimum filtering techniques. Position information can be improved by achieving sub-pixel resolution. Electronic noise is the limiting factor. Achieving sub-pixel resolution - position of the interaction better than one pixel pitch - in 3-D pixelated semiconductor detectors is a challenging task due to the fast transient characteristics of these signals. This work addresses two fundamental questions: the first is to determine the optimum filter, while the second is to estimate the achievable sub-pixel resolution using this filter. It is shown that the matched filter is the optimum filter when applying the signal-to-noise ratio criteria. Also, non-optimum filters are studied. The framework of 3-D waveform simulation using the Shockley-Ramo Theorem and the Hecht Equation for electron and hole trapping is presented in this work. This waveform simulator can be used to analyze current detectors as well as explore new ideas and concepts in future work. Numerical simulations show that assuming an electronic noise of 3.3 keV it is possible to subdivide the pixel region into 5x5 sub-pixels. After analyzing these results, it is suggested that sub-pixel information can also improve energy resolution. Current noise levels present the major drawback to both achieve sub-pixel resolution as well as improve energy resolution below the current limits. (author)

Event segmentation ability uniquely predicts event memory.

Science.gov (United States)

Sargent, Jesse Q; Zacks, Jeffrey M; Hambrick, David Z; Zacks, Rose T; Kurby, Christopher A; Bailey, Heather R; Eisenberg, Michelle L; Beck, Taylor M

2013-11-01

Memory for everyday events plays a central role in tasks of daily living, autobiographical memory, and planning. Event memory depends in part on segmenting ongoing activity into meaningful units. This study examined the relationship between event segmentation and memory in a lifespan sample to answer the following question: Is the ability to segment activity into meaningful events a unique predictor of subsequent memory, or is the relationship between event perception and memory accounted for by general cognitive abilities? Two hundred and eight adults ranging from 20 to 79years old segmented movies of everyday events and attempted to remember the events afterwards. They also completed psychometric ability tests and tests measuring script knowledge for everyday events. Event segmentation and script knowledge both explained unique variance in event memory above and beyond the psychometric measures, and did so as strongly in older as in younger adults. These results suggest that event segmentation is a basic cognitive mechanism, important for memory across the lifespan. Copyright © 2013 Elsevier B.V. All rights reserved.

Repair of a submucous cleft palate by W-pushback and levator repositioning without incision to the nasal mucosa.

Science.gov (United States)

Hwang, Kun

2012-03-01

The author created an innovative method of W-pushback and levator repositioning without having to make an incision to the nasal mucosa for submucous cleft palate repair.The W-shaped mucoperiosteal flap is outlined where the 2 peaks of W are the alveolar processes of both canine teeth and the midpoint of W is the anterior limit of the cleft notch of the hard palate. A short incision, medial to and behind the maxillary tuberosity and curved forward onto the palate and extended forward just medial to the alveolar process, is joined by a second incision from the apex of the cleft to the region of the canine tooth. The W-shaped mucoperiosteal flap is raised until the midline notch of the hard palate is exposed. The nasal mucosa and abnormally inserted levator veli palatini muscle to the posterior border of the hard palate bone are detached. By leaving the nasal mucosa intact, the detached levator veli palatini muscle is approximated at the midline and so the zona pellucida is obliterated. The cleft uvulas are cut in half and closed. The approximated W-flap is joined to the small anterior flap by 1 or more sutures (the W-pushback).Three patients were operated on with this technique without serious complications.The author believes that this method can make the levator sling and increase the length of the soft palate without making an incision to the nasal mucosa.

Analysis of a Steerable Needle for Fine Needle Aspiration and Biopsy: Efficiency and Radiation Dose Compared With a Conventional Straight Needle.

Science.gov (United States)

Rutigliano, Sandra; Abraham, John A; Kenneally, Barry E; Zoga, Adam C; Nevalainen, Mika; Roedl, Johannes B

Percutaneous computed tomography (CT)-guided needle biopsy has proven to be an efficacious method for sampling of many soft tissue lesions, especially deep-seated masses in the abdomen and pelvis. This study sought to test the potential for a novel steerable needle to improve localization and to reduce procedure duration and radiation dose compared with a conventional straight needle. A fresh, raw meat sample (lean bovine flank) was imbedded with cylindrical radiopaque and radiolucent obstacles designed to simulate vessels (radiolucent objects) and bones (radiopaque objects) on CT. A pit-containing olive (partially radiopaque) was imbedded beyond the obstacles to represent the target. Two sites on the surface of the meat were selected and marked to determine initial needle placement. Two radiologists with different levels of experience proceeded to position a straight needle and the steerable needle from each skin site to the target using CT guidance as efficiently as possible, avoiding the obstacles. The total positioning time, the number of CT scans required for positioning, and the number of repositioning events (partial withdrawal followed by advancement) were tracked for the straight and steerable needles. For the straight needle, total time to reach the target was 499 to 667 seconds (mean, 592 seconds); for the steerable needle, total time to reach the target was 281 to 343 seconds (mean, 309 seconds), on average, 48% lower. The number of CT scans needed for needle positioning averaged 6.25 for the straight needle and 3.5 for the steerable needle, which is 44% lower. Repositioning events (withdrawing and readvancing the needle) ranged from 3 to 10 for the straight needle (mean, 6.5) and 0 for the steerable needle. Using an in vitro model embedded with obstacles, the steerable needle performed better than a straight needle with regard to procedure time, needle repositioning events, and CT scans required for placement.

The pedicled masseter muscle transfer for smile reconstruction in facial paralysis: repositioning the origin and insertion.

Science.gov (United States)

Matic, Damir B; Yoo, John

2012-08-01

The pedicled masseter muscle transfer (PMMT) is introduced as a new reconstructive option for dynamic smile restoration in patients with facial paralysis. The masseter muscle is detached from both its origin and insertion and transferred to a new position to imitate the function of the native zygomaticus major muscle. Part one of this study consisted of cadaveric dissections of 4 heads (eight sides) in order to determine whether the masseter muscle could be (a) pedicled solely by its dominant neurovascular bundle and (b) repositioned directly over the native zygomaticus major. The second part of the study consisted of clinical assessments in three patients in order to confirm the applicability of this muscle transfer. Commissure excursion and vector of contraction following PMMT were compared to the non-paralyzed side. In all eight sides, the masseter muscles were successfully isolated on their pedicle and transposed on top of and in-line with the ipsilateral zygomaticus major. The mean length of the masseter and its angle from Frankfurt's horizontal line after transposition compared favorably to the native zygomaticus major muscle. In the clinical cases, the mean commissure movements of the paralyzed and normal sides were 7 mm and 12 mm respectively. The mean angles of commissural movement for the paralyzed and normal sides were 62° and 59° respectively. The PMMT can be used as a dynamic reconstruction for patients with permanent facial paralysis. As we gain experience with the PMMT, it may be possible to use it as a first-line option for patients not eligible for free micro-neurovascular reconstruction. Copyright © 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Outcome Assessment of the Marshall Coughing Test during Cervix Reposition Maneuver in Women with Urinary Stress Incontinence with/without Genital Prolapse.

Science.gov (United States)

Antovska, Vesna

2012-01-01

Objectives. Outcome assessment of the Marshall coughing test (MT) during cervix reposition maneuver (CRM) in women with urinary stress incontinence (USI) with/without genital prolapse (GP). Study Design. 268 patients, divided into USIg (n = 132) with isolated USI and USIGPg (n = 136) with USI and GP stage I/II, additionally divided into USIGP(A) (n = 78) with USI and GP stage I and USIGP(B) (n = 58) with USI and GP stage II, were evaluated with pelvic organ prolapse quantification (POPQ), MT, and CRM. Results. (a) 7.58% had (+) MT with CRM in USIg; (b) in up to 96.15% MT became negative during CRM in USIGP(A); (c) in 51.72% MT became positive only during CRM, as a sign for occult USI in USIGP(B); (d) point Aa (POPQ), which is bladder neck(BN) projection on the anterior vaginal wall, was situated higher in rest position (RP), but moved lower during the Valsalva maneuver (VM) in USIg versus USIGPg (P CRM could be useful arm in selection of (1) patients with isolated USI and great chance for postoperative failure; (2) patients with USI+GP stage I, who need GP repair during antistress surgery; (3) patients with USI + GP stage II, who need antistress procedure during vaginal hysterectomy.

Repositioning FDA Drugs as Potential Cruzain Inhibitors from Trypanosoma cruzi: Virtual Screening, In Vitro and In Vivo Studies

Directory of Open Access Journals (Sweden)

Isidro Palos

2017-06-01

Full Text Available Chagas disease (CD is a neglected disease caused by the parasite Trypanosoma cruzi, which affects underdeveloped countries. The current drugs of choice are nifurtimox and benznidazole, but both have severe adverse effects and less effectivity in chronic infections; therefore, the need to discover new drugs is essential. A computer-guided drug repositioning method was applied to identify potential FDA drugs (approved and withdrawn as cruzain (Cz inhibitors and trypanocidal effects were confirmed by in vitro and in vivo studies. 3180 FDA drugs were virtually screened using a structure-based approach. From a first molecular docking analysis, a set of 33 compounds with the best binding energies were selected. Subsequent consensus affinity binding, ligand amino acid contact clustering analysis, and ranked position were used to choose four known pharmacological compounds to be tested in vitro. Mouse blood samples infected with trypomastigotes from INC-5 and NINOA strains were used to test the trypanocidal effect of four selected compounds. Among these drugs, one fibrate antilipemic (etofyllin clofibrate and three β-lactam antibiotics (piperacillin, cefoperazone, and flucloxacillin showed better trypanocidal effects (LC50 range 15.8–26.1 μg/mL in comparison with benznidazole and nifurtimox (LC50 range 33.1–46.7 μg/mL. A short-term in vivo evaluation of these compounds showed a reduction of parasitemia in infected mice (range 90–60% at 6 h, but this was low compared to benznidazole (50%. This work suggests that four known FDA drugs could be used to design and obtain new trypanocidal agents.

Event dependent sampling of recurrent events

DEFF Research Database (Denmark)

Kvist, Tine Kajsa; Andersen, Per Kragh; Angst, Jules

2010-01-01

The effect of event-dependent sampling of processes consisting of recurrent events is investigated when analyzing whether the risk of recurrence increases with event count. We study the situation where processes are selected for study if an event occurs in a certain selection interval. Motivation...... retrospective and prospective disease course histories are used. We examine two methods to correct for the selection depending on which data are used in the analysis. In the first case, the conditional distribution of the process given the pre-selection history is determined. In the second case, an inverse...

Ion-ion coincidence imaging at high event rate using an in-vacuum pixel detector

Science.gov (United States)

Long, Jingming; Furch, Federico J.; Durá, Judith; Tremsin, Anton S.; Vallerga, John; Schulz, Claus Peter; Rouzée, Arnaud; Vrakking, Marc J. J.

2017-07-01

A new ion-ion coincidence imaging spectrometer based on a pixelated complementary metal-oxide-semiconductor detector has been developed for the investigation of molecular ionization and fragmentation processes in strong laser fields. Used as a part of a velocity map imaging spectrometer, the detection system is comprised of a set of microchannel plates and a Timepix detector. A fast time-to-digital converter (TDC) is used to enhance the ion time-of-flight resolution by correlating timestamps registered separately by the Timepix detector and the TDC. In addition, sub-pixel spatial resolution (principle experiment on strong field dissociative double ionization of carbon dioxide molecules (CO2), using a 400 kHz repetition rate laser system. The experimental results demonstrate that the spectrometer can detect multiple ions in coincidence, making it a valuable tool for studying the fragmentation dynamics of molecules in strong laser fields.

Event Shape Sorting: selecting events with similar evolution

Directory of Open Access Journals (Sweden)

Tomášik Boris

2017-01-01

Full Text Available We present novel method for the organisation of events. The method is based on comparing event-by-event histograms of a chosen quantity Q that is measured for each particle in every event. The events are organised in such a way that those with similar shape of the Q-histograms end-up placed close to each other. We apply the method on histograms of azimuthal angle of the produced hadrons in ultrarelativsitic nuclear collisions. By selecting events with similar azimuthal shape of their hadron distribution one chooses events which are likely that they underwent similar evolution from the initial state to the freeze-out. Such events can more easily be compared to theoretical simulations where all conditions can be controlled. We illustrate the method on data simulated by the AMPT model.

O processo da bibliomineração: repositório de dados e mineração de dados para tomada de decisão em bibliotecas

Directory of Open Access Journals (Sweden)

Scott Nicholson

Full Text Available Apresenta uma metodologia operacional integrada, utilizando técnicas de repositórios de dados (data warehousing e mineração de dados (data mining, e combinando ferramentas estatísticas com reconhecimento de padrões. Tendo em vista a utilização de recursos, o objetivo principal é chegar a um entendimento melhor do comportamento de comunidades de usuários. O anonimato dos usuários fica inteiramente assegurado na aplicação do modelo, pelo qual são processados os dados oriundos de arquivos transacionais da biblioteca. O próprio processo da bibliomineração consiste basicamente em coletar, depurar e anonimizar os dados, visando, precipuamente, a descoberta de padrões subjacentes. Os resultados podem ser combinados com diferentes variáveis, antes de sua utilização na tomada de decisão pela Administração da biblioteca.

Viewing angle switching of patterned vertical alignment liquid crystal display

International Nuclear Information System (INIS)

Lim, Young Jin; Jeong, Eun; Chin, Mi Hyung; Lee, Seung Hee; Ji, Seunghoon; Lee, Gi-Dong

2008-01-01

Viewing angle control of a patterned vertical alignment (PVA) liquid crystal display using only one panel is investigated. In conventional PVA modes, a vertically aligned liquid crystal (LC) director tilts down in four directions making 45 deg. with respect to crossed polarizers to exhibit a wide viewing angle. In the viewing angle control device, one pixel was divided into two sub-pixels such that the LC director in the main pixel is controlled to be tilted down in multiple directions making an angle with the polarizer, playing the role of main display with the wide viewing angle, while the LC director in the sub-pixel is controlled to be tilted down to the polarizer axis, playing the role of sub-pixel to the viewing angle control for the narrow viewing angle. Using sub-pixel control, light leakage or any type of information such as characters and image can be generated in oblique viewing directions without distorting the image quality in the normal direction, which will prevent others from peeping at the displayed image by overlapping the displayed image with the made image

A controllable viewing angle LCD with an optically isotropic liquid crystal

International Nuclear Information System (INIS)

Kim, Min Su; Lim, Young Jin; Yoon, Sukin; Kang, Shin-Woong; Lee, Seung Hee; Kim, Miyoung; Wu, Shin-Tson

2010-01-01

An optically isotropic liquid crystal (LC) such as a blue phase LC or an optically isotropic nano-structured LC exhibits a very wide viewing angle because the induced birefringence is along the in-plane electric field. Utilizing such a material, we propose a liquid crystal display (LCD) whose viewing angle can be switched from wide view to narrow view using only one panel. In the device, each pixel is divided into two parts: a major pixel and a sub-pixel. The main pixels display the images while the sub-pixels control the viewing angle. In the main pixels, birefringence is induced by horizontal electric fields through inter-digital electrodes leading to a wide viewing angle, while in the sub-pixels, birefringence is induced by the vertical electric field so that phase retardation occurs only at oblique angles. As a result, the dark state (or contrast ratio) of the entire pixel can be controlled by the voltage of the sub-pixels. Such a switchable viewing angle LCD is attractive for protecting personal privacy.

Numerical evaluation of methods for computing tomographic projections

International Nuclear Information System (INIS)

Zhuang, W.; Gopal, S.S.; Hebert, T.J.

1994-01-01

Methods for computing forward/back projections of 2-D images can be viewed as numerical integration techniques. The accuracy of any ray-driven projection method can be improved by increasing the number of ray-paths that are traced per projection bin. The accuracy of pixel-driven projection methods can be increased by dividing each pixel into a number of smaller sub-pixels and projecting each sub-pixel. The authors compared four competing methods of computing forward/back projections: bilinear interpolation, ray-tracing, pixel-driven projection based upon sub-pixels, and pixel-driven projection based upon circular, rather than square, pixels. This latter method is equivalent to a fast, bi-nonlinear interpolation. These methods and the choice of the number of ray-paths per projection bin or the number of sub-pixels per pixel present a trade-off between computational speed and accuracy. To solve the problem of assessing backprojection accuracy, the analytical inverse Fourier transform of the ramp filtered forward projection of the Shepp and Logan head phantom is derived

Event generators for address event representation transmitters

Science.gov (United States)

Serrano-Gotarredona, Rafael; Serrano-Gotarredona, Teresa; Linares Barranco, Bernabe

2005-06-01

Address Event Representation (AER) is an emergent neuromorphic interchip communication protocol that allows for real-time virtual massive connectivity between huge number neurons located on different chips. By exploiting high speed digital communication circuits (with nano-seconds timings), synaptic neural connections can be time multiplexed, while neural activity signals (with mili-seconds timings) are sampled at low frequencies. Also, neurons generate 'events' according to their activity levels. More active neurons generate more events per unit time, and access the interchip communication channel more frequently, while neurons with low activity consume less communication bandwidth. In a typical AER transmitter chip, there is an array of neurons that generate events. They send events to a peripheral circuitry (let's call it "AER Generator") that transforms those events to neurons coordinates (addresses) which are put sequentially on an interchip high speed digital bus. This bus includes a parallel multi-bit address word plus a Rqst (request) and Ack (acknowledge) handshaking signals for asynchronous data exchange. There have been two main approaches published in the literature for implementing such "AER Generator" circuits. They differ on the way of handling event collisions coming from the array of neurons. One approach is based on detecting and discarding collisions, while the other incorporates arbitration for sequencing colliding events . The first approach is supposed to be simpler and faster, while the second is able to handle much higher event traffic. In this article we will concentrate on the second arbiter-based approach. Boahen has been publishing several techniques for implementing and improving the arbiter based approach. Originally, he proposed an arbitration squeme by rows, followed by a column arbitration. In this scheme, while one neuron was selected by the arbiters to transmit his event out of the chip, the rest of neurons in the array were

SENTINEL EVENTS

Directory of Open Access Journals (Sweden)

Andrej Robida

2004-09-01

Full Text Available Background. The Objective of the article is a two year statistics on sentinel events in hospitals. Results of a survey on sentinel events and the attitude of hospital leaders and staff are also included. Some recommendations regarding patient safety and the handling of sentinel events are given.Methods. In March 2002 the Ministry of Health introduce a voluntary reporting system on sentinel events in Slovenian hospitals. Sentinel events were analyzed according to the place the event, its content, and root causes. To show results of the first year, a conference for hospital directors and medical directors was organized. A survey was conducted among the participants with the purpose of gathering information about their view on sentinel events. One hundred questionnaires were distributed.Results. Sentinel events. There were 14 reports of sentinel events in the first year and 7 in the second. In 4 cases reports were received only after written reminders were sent to the responsible persons, in one case no reports were obtained. There were 14 deaths, 5 of these were in-hospital suicides, 6 were due to an adverse event, 3 were unexplained. Events not leading to death were a suicide attempt, a wrong side surgery, a paraplegia after spinal anaesthesia, a fall with a femoral neck fracture, a damage of the spleen in the event of pleural space drainage, inadvertent embolization with absolute alcohol into a femoral artery and a physical attack on a physician by a patient. Analysis of root causes of sentinel events showed that in most cases processes were inadequate.Survey. One quarter of those surveyed did not know about the sentinel events reporting system. 16% were having actual problems when reporting events and 47% beleived that there was an attempt to blame individuals. Obstacles in reporting events openly were fear of consequences, moral shame, fear of public disclosure of names of participants in the event and exposure in mass media. The majority of

Event-by-event simulation of quantum phenomena

NARCIS (Netherlands)

Raedt, H. De; Raedt, K. De; Michielsen, K.; Landau, DP; Lewis, SP; Schuttler, HB

2006-01-01

In various basic experiments in quantum physics, observations are recorded event-by-event. The final outcome of such experiments can be computed according to the rules of quantum theory but quantum theory does not describe single events. In this paper, we describe a stimulation approach that does

Targeting Phosphatidylinositol 4-Kinase IIIα for Radiosensitization: A Potential Model of Drug Repositioning Using an Anti-Hepatitis C Viral Agent

Energy Technology Data Exchange (ETDEWEB)

Kwon, Jeanny [Department of Radiation Oncology, Graduate School of Medicine, Seoul National University, Seoul (Korea, Republic of); Kim, Dan Hyo; Park, Ji Min [Medical Science Research Institute, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Park, Young Hee [Department of Radiation Oncology, Graduate School of Medicine, Seoul National University, Seoul (Korea, Republic of); Hwang, Yeo Hyun [Medical Science Research Institute, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Wu, Hong-Gyun [Department of Radiation Oncology, Graduate School of Medicine, Seoul National University, Seoul (Korea, Republic of); Institute of Radiation Medicine, Seoul National University, Seoul (Korea, Republic of); Shin, Kyung Hwan [Department of Radiation Oncology, Graduate School of Medicine, Seoul National University, Seoul (Korea, Republic of); Kim, In Ah, E-mail: inah228@snu.ac.kr [Department of Radiation Oncology, Graduate School of Medicine, Seoul National University, Seoul (Korea, Republic of); Medical Science Research Institute, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Institute of Radiation Medicine, Seoul National University, Seoul (Korea, Republic of); Cancer Research Institute, Seoul National University, Seoul (Korea, Republic of)

2016-11-15

Purpose: To investigate which isotype of phosphatidylinositol 4-kinase (PI4K) may affect radiosensitivity and examine whether anti–hepatitis C viral (HCV) agents, some of which have been shown to inhibit PI4K IIIα activity, could be repositioned as a radiosensitizer in human cancer cells. Methods and Materials: U251, BT474, and HepG2 cell lines and normal human astrocyte were used. Ribonucleic acid interference, clonogenic assays, Western blotting, immunofluorescence, annexin V assay, lysotracker staining, and β-galactosidase assay were performed. Results: Of the 4 PI4K isotypes, specific inhibition of IIIα increased radiosensitivity. For pharmacologic inhibition of PI4K IIIα, we screened 9 anti-HCV agents by half-maximal inhibitory concentration assay. Simeprevir was selected, and its inhibition of PI4K IIIα activity was confirmed. Combination of simeprevir treatment and radiation significantly attenuated expression of phospho-phospho-PKC and phospho-Akt and increased radiation-induced cell death in tested cell lines. Pretreatment with simeprevir prolonged γH2AX foci formation and down-regulation of phospho-DNA-PKcs, indicating impairment of nonhomologous end-joining repair. Cells pretreated with simeprevir exhibited mixed modes of cell death, including apoptosis and autophagy. Conclusion: These data demonstrate that targeting PI4K IIIα using an anti-HCV agent is a viable approach to enhance the therapeutic efficacy of radiation therapy in various human cancers, such as glioma, breast, and hepatocellular carcinoma.

Estimate of neutrons event-by-event in DREAM

International Nuclear Information System (INIS)

Hauptman, John

2009-01-01

We have measured the contribution of neutrons to hadronic showers in the DREAM module event-by-event as a means to estimate the event-by-event fluctuations in binding energy losses by hadrons as they break up nuclei of the Cu absorber. We make a preliminary assessment of the consequences for hadronic energy resolution in dual-readout calorimeters.

Event Investigation

International Nuclear Information System (INIS)

Korosec, D.

2000-01-01

The events in the nuclear industry are investigated from the license point of view and from the regulatory side too. It is well known the importance of the event investigation. One of the main goals of such investigation is to prevent the circumstances leading to the event and the consequences of the event. The protection of the nuclear workers against nuclear hazard, and the protection of general public against dangerous effects of an event could be achieved by systematic approach to the event investigation. Both, the nuclear safety regulatory body and the licensee shall ensure that operational significant events are investigated in a systematic and technically sound manner to gather information pertaining to the probable causes of the event. One of the results should be appropriate feedback regarding the lessons of the experience to the regulatory body, nuclear industry and general public. In the present paper a general description of systematic approach to the event investigation is presented. The systematic approach to the event investigation works best where cooperation is present among the different divisions of the nuclear facility or regulatory body. By involving management and supervisors the safety office can usually improve their efforts in the whole process. The end result shall be a program which serves to prevent events and reduce the time and efforts solving the root cause which initiated each event. Selection of the proper method for the investigation and an adequate review of the findings and conclusions lead to the higher level of the overall nuclear safety. (author)

Dosimetric implications of changes in patient repositioning and organ motion in conformal radiotherapy for prostate cancer

International Nuclear Information System (INIS)

Miralbell, Raymond; Oezsoy, Orhan; Pugliesi, Angela; Carballo, Natalia; Arnalte, Raquel; Escude, Lluis; Jargy, Clara; Nouet, Philippe; Rouzaud, Michel

2003-01-01

Purpose: To assess the influence of patient repositioning and organ motion on dose distribution within the prostate and the seminal vesicles (clinical target volume, (CTV)). Material and methods: Nine patients were simulated and treated in the supine position, with an empty bladder, and without immobilization devices. While on treatment, patients underwent weekly pelvic computed tomography (CT) scans under conditions identical to those at simulation. Patients were aligned using lasers on anterior and lateral skin tattoos, onto which lead markers were placed. After each CT scan (n=53) the CTV was redefined by contouring, and a new isocenter was obtained. A six-field technique was used. The field margins around the CTV were 20 mm in the cranio-caudal axis, and 13 mm in the other axes, except in the lateral fields where a 10 mm posterior margin was used. Dose-volume histograms (DVHs) for each organ were compared with those determined at simulation, using the notion of the proportional change in the area under the CTV-DVH curve resulting from a change in treatment plan (cDVH). Results: The reproducibility of the dose distribution was good for the prostate (%cDVH, mean±SD: -0.97±2.11%) and less than optimal for the seminal vesicles (%cDVH, mean±SD: -4.66±10.45%). When correlating prostate %cDVH variations with displacements of the isocenter in the Y axis (antero-posterior) the %cDVH exceeded (-)5% in only two dosimetries, both with an isocenter shift of >10 mm. For the seminal vesicles, however, ten out of 53 dosimetries showed a %cDVH exceeding (-) 5%. In nine of these ten dose distribution studies the posterior shift of the isocenter exceeded 8 mm. Conclusions: Precise targeting of prostate radiotherapy is primarily dependent on careful daily set-up and on random changes in rectal geometry. Margins no less than 10 mm around the prostate and at least 15 mm around the seminal vesicles are probably necessary to insure adequate target coverage with a six

[Supporting a teenager confronted with a traumatic experience].

Science.gov (United States)

Merchin, Clara; Benoit de Coignac, Agathe; Moro, Marie Rose

2015-01-01

Everyone reacts differently to a traumatic event. There is a risk of underestimating a teenager's traumatic experience by considering only the usual post-traumatic stress diagnosis criteria. However, when the trauma has not been able to be sufficiently developed, the adolescent's suffering is revealed through their behaviour. The therapeutic support of the youngster and their family enables them to reposition the traumatic event within the continuity of their history and to relaunch a thought process, often frozen by the traumatic experience. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Biotin-targeted Pluronic(®) P123/F127 mixed micelles delivering niclosamide: A repositioning strategy to treat drug-resistant lung cancer cells.

Science.gov (United States)

Russo, Annapina; Pellosi, Diogo Silva; Pagliara, Valentina; Milone, Maria Rita; Pucci, Biagio; Caetano, Wilker; Hioka, Noboru; Budillon, Alfredo; Ungaro, Francesca; Russo, Giulia; Quaglia, Fabiana

2016-09-10

With the aim to develop alternative therapeutic tools for the treatment of resistant cancers, here we propose targeted Pluronic(®) P123/F127 mixed micelles (PMM) delivering niclosamide (NCL) as a repositioning strategy to treat multidrug resistant non-small lung cancer cell lines. To build multifunctional PMM for targeting and imaging, Pluronic(®) F127 was conjugated with biotin, while Pluronic(®) P123 was fluorescently tagged with rhodamine B, in both cases at one of the two hydroxyl end groups. This design intended to avoid any interference of rhodamine B on biotin exposition on PMM surface, which is a key fundamental for cell trafficking studies. Biotin-decorated PMM were internalized more efficiently than non-targeted PMM in A549 lung cancer cells, while very low internalization was found in NHI3T3 normal fibroblasts. Biotin-decorated PMM entrapped NCL with good efficiency, displayed sustained drug release in protein-rich media and improved cytotoxicity in A549 cells as compared to free NCL (Pbiotin-decorated PMM carrying NCL at low doses demonstrated a significantly higher cytotoxicity than free NCL in CPr-A549. These results point at NCL-based regimen with targeted PMM as a possible second-line chemotherapy for lung cancer showing cisplatin or multidrug resistance. Copyright © 2016 Elsevier B.V. All rights reserved.

Satisfactory clinical outcome following delayed repositioning of a traumatic post-LASIK flap with dislocation and shrinkage managed by irrigation, stretching, and debridement.

Science.gov (United States)

Xu, Ye-Sheng; Xie, Wen-Jia; Yao, Yu-Feng

2017-06-01

To report surgical management and favorable outcome in a case with delayed repair of traumatic laser in situ keratomileusis (LASIK) flap dislocation with shrinkage and folds. A 30-year-old man with a five-year history of bilateral LASIK experienced blunt trauma to his right eye followed by decreased vision for 5 weeks. The surgical management included initially softening the flap by irrigation with balanced salt solution (BSS). The shrinkage folds were carefully and gently stretched by scraping with a 26-gauge cannula accompanied by BSS irrigation. All of the epithelial ingrowth on the flap inner surface and on the bed was thoroughly debrided by scraping and irrigation. After the flap was repositioned to match its original margin, a soft bandage contact lens was placed. At his initial visit, slit-lamp microscopy and optical coherence tomography (OCT) showed shrinkage of the LASIK flap with an elevated margin approximately 3 mm above the original position. The flap covered half of the pupil and had multiple horizontal folds. Two months after surgery, the flap remained well positioned with only faint streaks in the anterior stroma. The uncorrected visual acuity of the right eye was 20/20 with a manifest refraction of Plano. For delayed repair of traumatically dislocated LASIK flaps, sufficient softening by BSS, stretching the shrinkage folds, and thorough debridement of ingrowth epithelium enable resetting the flap and provide satisfactory results.

Event-by-event fluctuations at SPS

CERN Document Server

Appelshauser, Harald; Adamova, D.; Agakichiev, G.; Belaga, V.; Braun-Munzinger, P.; Castillo, A.; Cherlin, A.; Damjanovic, S.; Dietel, T.; Dietrich, L.; Drees, A.; Esumi, S.I.; Filimonov, K.; Fomenko, K.; Fraenkel, Z.; Garabatos, C.; Glassel, P.; Hering, G.; Holeczek, J.; Kushpil, V.; Lenkeit, B.; Ludolphs, W.; Maas, A.; Marn, A.; Milosevic, J.; Milov, A.; Miskowiec, D.; Panebrattsev, Yu.; Petchenova, O.; Petracek, V.; Pfeiffer, A.; Rak, J.; Ravinovich, I.; Rehak, P.; Schmitz, W.; Schukraft, J.; Sedykh, S.; Shimansky, S.; Slvova, J.; Stachel, J.; Sumbera, M.; Tilsner, H.; Tserruya, Itzhak; Wessels, J.P.; Wienold, T.; Windelband, B.; Wurm, J.P.; Xie, W.; Yurevich, S.; Yurevich, V.; Appelshauser, Harald; Sako, Hiro

2005-01-01

Results on event-by-event fluctuations of the mean transverse momentum and net charge in Pb-Au collisions, measured by the CERES Collaboration at CERN-SPS, are presented. We discuss the centrality and beam energy dependence and compare our data to cascade calculations.

Proton transfer events in GFP.

Science.gov (United States)

Di Donato, Mariangela; van Wilderen, Luuk J G W; Van Stokkum, Ivo H M; Stuart, Thomas Cohen; Kennis, John T M; Hellingwerf, Klaas J; van Grondelle, Rienk; Groot, Marie Louise

2011-09-28

Proton transfer is one of the most important elementary processes in biology. Green fluorescent protein (GFP) serves as an important model system to elucidate the mechanistic details of this reaction, because in GFP proton transfer can be induced by light absorption. Illumination initiates proton transfer through a 'proton-wire', formed by the chromophore (the proton donor), water molecule W22, Ser205 and Glu222 (the acceptor), on a picosecond time scale. To obtain a more refined view of this process, we have used a combined approach of time resolved mid-infrared spectroscopy and visible pump-dump-probe spectroscopy to resolve with atomic resolution how and how fast protons move through this wire. Our results indicate that absorption of light by GFP induces in 3 ps (10 ps in D(2)O) a shift of the equilibrium positions of all protons in the H-bonded network, leading to a partial protonation of Glu222 and to a so-called low barrier hydrogen bond (LBHB) for the chromophore's proton, giving rise to dual emission at 475 and 508 nm. This state is followed by a repositioning of the protons on the wire in 10 ps (80 ps in D(2)O), ultimately forming the fully deprotonated chromophore and protonated Glu222.

Event Displays for the Visualization of CMS Events

CERN Document Server

Jones, Christopher Duncan

2010-01-01

During the last year the CMS experiment engaged in consolidation of its existing event display programs. The core of the new system is based on the Fireworks event display program which was by-design directly integrated with the CMS Event Data Model (EDM) and the light version of the software framework (FWLite). The Event Visualization Environment (EVE) of the ROOT framework is used to manage a consistent set of 3D and 2D views, selection, user-feedback and user-interaction with the graphics windows; several EVE components were developed by CMS in collaboration with the ROOT project. In event display operation simple plugins are registered into the system to perform conversion from EDM collections into their visual representations which are then managed by the application. Full event navigation and filtering as well as collection-level filtering is supported. The same data-extraction principle can also be applied when Fireworks will eventually operate as a service within the full software framework.

Event Display for the Visualization of CMS Events

Science.gov (United States)

Bauerdick, L. A. T.; Eulisse, G.; Jones, C. D.; Kovalskyi, D.; McCauley, T.; Mrak Tadel, A.; Muelmenstaedt, J.; Osborne, I.; Tadel, M.; Tu, Y.; Yagil, A.

2011-12-01

During the last year the CMS experiment engaged in consolidation of its existing event display programs. The core of the new system is based on the Fireworks event display program which was by-design directly integrated with the CMS Event Data Model (EDM) and the light version of the software framework (FWLite). The Event Visualization Environment (EVE) of the ROOT framework is used to manage a consistent set of 3D and 2D views, selection, user-feedback and user-interaction with the graphics windows; several EVE components were developed by CMS in collaboration with the ROOT project. In event display operation simple plugins are registered into the system to perform conversion from EDM collections into their visual representations which are then managed by the application. Full event navigation and filtering as well as collection-level filtering is supported. The same data-extraction principle can also be applied when Fireworks will eventually operate as a service within the full software framework.

Event Display for the Visualization of CMS Events

International Nuclear Information System (INIS)

Bauerdick, L A T; Eulisse, G; Jones, C D; McCauley, T; Osborne, I; Kovalskyi, D; Tadel, A Mrak; Muelmenstaedt, J; Tadel, M; Tu, Y; Yagil, A

2011-01-01

During the last year the CMS experiment engaged in consolidation of its existing event display programs. The core of the new system is based on the Fireworks event display program which was by-design directly integrated with the CMS Event Data Model (EDM) and the light version of the software framework (FWLite). The Event Visualization Environment (EVE) of the ROOT framework is used to manage a consistent set of 3D and 2D views, selection, user-feedback and user-interaction with the graphics windows; several EVE components were developed by CMS in collaboration with the ROOT project. In event display operation simple plugins are registered into the system to perform conversion from EDM collections into their visual representations which are then managed by the application. Full event navigation and filtering as well as collection-level filtering is supported. The same data-extraction principle can also be applied when Fireworks will eventually operate as a service within the full software framework.

Events and mega events: leisure and business in tourism

Directory of Open Access Journals (Sweden)

Ricardo Alexandre Paiva

2015-12-01

Full Text Available The promotion of events and mega events mobilizes at the same time, in a concatenated way or not, leisure and business practices, which are captured by the tourism industry as a stimulus for the reproduction of capitalism, by the amount of other activities which raise (primary, secondary and tertiary , placing the architecture and the city as protagonists in contemporary urban development. In this sense, the article analyzes the articulation of events and mega events to the provision of architecture and urban infrastructure, as well as the construction of the tourist image of the places, motivated by leisure and business activities. The methodological procedures have theoretical and exploratory character and have multidisciplinary intentions. This will be discussed, in a historical perspective, the concepts of leisure and business activities that raise as moving or traveling; next it will be delimited similarities and differences between tourism events and business tourism, entering after the analysis of the distinctions between events and mega events, highlighting the complexity and the role of mega-events as a major symptom of globalization; finally it will be presented the spatial scale developments in architecture and the city in the realization of (mega events, as well as its impact on the city's image. As a synthesis, it is important to notice that spatial developments business tourism, events and mega events are manifested in various scales and with different levels of complexity, revealing the strengths and / or weaknesses of the places. The urban planning, architecture and urbanism are important objects of knowledge and spatial intervention to ensure infrastructure and urban and architectural structures appropriate for events, which should be sensitive to the demands of tourists and host communities.

ATLAS TDAQ/DCS Event Filter Event Handler Requirements

CERN Document Server

Bee, C P; Meessen, C; Qian, Z; Touchard, F; Green, P; Pinfold, J L; Wheeler, S; Negri, A; Scannicchio, D A; Vercesi, V

2002-01-01

The second iteration of the Software Development Process of the ATLAS Event Filter has been launched. A summary of the design phase of the first iteration is given in the introduction. The document gives constraints, use cases, functional and non-functional requirements for the Event Handler sub-system of the Event Filter.

Event display of a H -> 4mu candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 4mu candidate event with m(4l) = 124.1 (125.1) GeV without (with) Z mass constraint. The masses of the lepton pairs are 86.3 GeV and 31.6 GeV. The event was recorded by ATLAS on 10-Jun-2012, 13:24:31 CEST in run number 204769 as event number 71902630. Muon tracks are colored red.

The patient's safety - For a dynamics of improvement. Nr 2. The 'blank' first session

International Nuclear Information System (INIS)

2011-11-01

This publication addresses the stakes associated with the first radiotherapy session which is commonly called the 'blank' session. After some figures concerning radiotherapy patients and event declarations, it analyses 13 of these events in terms of number of sessions, location, treatment technique, and error detection (when, by whom). It evokes the consequences of events, and identifies the main causes of these events (positioning controls, work organisation, technical tools and devices). It outlines some good practices: a systematic 'blank' first session before any radiotherapy, a rigorous control of positioning, avoidance of patient repositioning errors. Some innovative techniques of imagery-guided radiotherapy are evoked. Members of radiotherapy departments outline the importance of this first 'blank' session, their own role, and successful practices

Repositioning realism

CSIR Research Space (South Africa)

Ruttkamp-Bloem, E

2015-03-01

Full Text Available "Naturalised realism" is presented as a version of realism which is more compatible with the history of science than convergent or explanationist forms of realism. The account is unpacked according to four theses : 1) Whether realism is warranted...

Event display of a H -> 4mu candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 4mu candidate event with m(4l) = 124.1 (125.1) GeV without (with) Z mass constraint. The masses of the lepton pairs are 86.3 GeV and 31.6 GeV. The event was recorded by ATLAS on 10-Jun-2012, 13:24:31 CEST in run number 204769 as event number 71902630. Zoom into the tracking detector. Muon tracks are colored red.

MadEvent: automatic event generation with MadGraph

International Nuclear Information System (INIS)

Maltoni, Fabio; Stelzer, Tim

2003-01-01

We present a new multi-channel integration method and its implementation in the multi-purpose event generator MadEvent, which is based on MadGraph. Given a process, MadGraph automatically identifies all the relevant subprocesses, generates both the amplitudes and the mappings needed for an efficient integration over the phase space, and passes them to MadEvent. As a result, a process-specific, stand-alone code is produced that allows the user to calculate cross sections and produce unweighted events in a standard output format. Several examples are given for processes that are relevant for physics studies at present and forthcoming colliders. (author)

Event display of a H -> 4e candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. The tracks and clusters of the two electron pairs are colored red and blue, respectively.

Construction and Updating of Event Models in Auditory Event Processing

Science.gov (United States)

Huff, Markus; Maurer, Annika E.; Brich, Irina; Pagenkopf, Anne; Wickelmaier, Florian; Papenmeier, Frank

2018-01-01

Humans segment the continuous stream of sensory information into distinct events at points of change. Between 2 events, humans perceive an event boundary. Present theories propose changes in the sensory information to trigger updating processes of the present event model. Increased encoding effort finally leads to a memory benefit at event…

ENGAGING STUDENTS THROUGH EVENT MARKETING: AN EXAMPLE OF UNIVERSITY ENTREPRENEURSHIP EVENT

Directory of Open Access Journals (Sweden)

Alev KOÇAK ALAN

2017-12-01

Full Text Available Despite the growing importance of event marketing, this study investigated the impact of entrepreneurship event on university students which was hosting by one of the leading university in Turkey. Three different assets of event image (event inventiveness, event appropriateness, event adequacy were proposed to influence students’ satisfaction and revisit intentions. Research conducted to 468 students which participate in the entrepreneurship event for two days. For the analyses structural equation modeling technique was used. It was found that (i the dimensions of event image (inventiveness, appropriateness, and adequacy have an impact on students’ satisfaction and (ii students’ satisfaction was a main driver of their revisit intention. Results, future researches and managerial implications were addressed.

High Precision Edge Detection Algorithm for Mechanical Parts

Science.gov (United States)

Duan, Zhenyun; Wang, Ning; Fu, Jingshun; Zhao, Wenhui; Duan, Boqiang; Zhao, Jungui

2018-04-01

High precision and high efficiency measurement is becoming an imperative requirement for a lot of mechanical parts. So in this study, a subpixel-level edge detection algorithm based on the Gaussian integral model is proposed. For this purpose, the step edge normal section line Gaussian integral model of the backlight image is constructed, combined with the point spread function and the single step model. Then gray value of discrete points on the normal section line of pixel edge is calculated by surface interpolation, and the coordinate as well as gray information affected by noise is fitted in accordance with the Gaussian integral model. Therefore, a precise location of a subpixel edge was determined by searching the mean point. Finally, a gear tooth was measured by M&M3525 gear measurement center to verify the proposed algorithm. The theoretical analysis and experimental results show that the local edge fluctuation is reduced effectively by the proposed method in comparison with the existing subpixel edge detection algorithms. The subpixel edge location accuracy and computation speed are improved. And the maximum error of gear tooth profile total deviation is 1.9 μm compared with measurement result with gear measurement center. It indicates that the method has high reliability to meet the requirement of high precision measurement.

Inverse analysis of non-uniform temperature distributions using multispectral pyrometry

Science.gov (United States)

Fu, Tairan; Duan, Minghao; Tian, Jibin; Shi, Congling

2016-05-01

Optical diagnostics can be used to obtain sub-pixel temperature information in remote sensing. A multispectral pyrometry method was developed using multiple spectral radiation intensities to deduce the temperature area distribution in the measurement region. The method transforms a spot multispectral pyrometer with a fixed field of view into a pyrometer with enhanced spatial resolution that can give sub-pixel temperature information from a "one pixel" measurement region. A temperature area fraction function was defined to represent the spatial temperature distribution in the measurement region. The method is illustrated by simulations of a multispectral pyrometer with a spectral range of 8.0-13.0 μm measuring a non-isothermal region with a temperature range of 500-800 K in the spot pyrometer field of view. The inverse algorithm for the sub-pixel temperature distribution (temperature area fractions) in the "one pixel" verifies this multispectral pyrometry method. The results show that an improved Levenberg-Marquardt algorithm is effective for this ill-posed inverse problem with relative errors in the temperature area fractions of (-3%, 3%) for most of the temperatures. The analysis provides a valuable reference for the use of spot multispectral pyrometers for sub-pixel temperature distributions in remote sensing measurements.

Vaccine Adverse Events

Science.gov (United States)

... for Biologics Evaluation & Research Vaccine Adverse Events Vaccine Adverse Events Share Tweet Linkedin Pin it More sharing ... in the primary immunization series in infants Report Adverse Event Report a Vaccine Adverse Event Contact FDA ( ...

Event group importance measures for top event frequency analyses

International Nuclear Information System (INIS)

1995-01-01

Three traditional importance measures, risk reduction, partial derivative, nd variance reduction, have been extended to permit analyses of the relative importance of groups of underlying failure rates to the frequencies of resulting top events. The partial derivative importance measure was extended by assessing the contribution of a group of events to the gradient of the top event frequency. Given the moments of the distributions that characterize the uncertainties in the underlying failure rates, the expectation values of the top event frequency, its variance, and all of the new group importance measures can be quantified exactly for two familiar cases: (1) when all underlying failure rates are presumed independent, and (2) when pairs of failure rates based on common data are treated as being equal (totally correlated). In these cases, the new importance measures, which can also be applied to assess the importance of individual events, obviate the need for Monte Carlo sampling. The event group importance measures are illustrated using a small example problem and demonstrated by applications made as part of a major reactor facility risk assessment. These illustrations and applications indicate both the utility and the versatility of the event group importance measures

Event group importance measures for top event frequency analyses

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-07-31

Three traditional importance measures, risk reduction, partial derivative, nd variance reduction, have been extended to permit analyses of the relative importance of groups of underlying failure rates to the frequencies of resulting top events. The partial derivative importance measure was extended by assessing the contribution of a group of events to the gradient of the top event frequency. Given the moments of the distributions that characterize the uncertainties in the underlying failure rates, the expectation values of the top event frequency, its variance, and all of the new group importance measures can be quantified exactly for two familiar cases: (1) when all underlying failure rates are presumed independent, and (2) when pairs of failure rates based on common data are treated as being equal (totally correlated). In these cases, the new importance measures, which can also be applied to assess the importance of individual events, obviate the need for Monte Carlo sampling. The event group importance measures are illustrated using a small example problem and demonstrated by applications made as part of a major reactor facility risk assessment. These illustrations and applications indicate both the utility and the versatility of the event group importance measures.

Event display of a H -> 4e candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. The tracks of the two electron pairs are colored red, the clusters in the LAr calorimeter are colored darkgreen.

Event display of a H -> 4e candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. Zoom into the tracking detector. The tracks and clusters of the two electron pairs are colored red and blue, respectively.

Event Modeling

DEFF Research Database (Denmark)

Bækgaard, Lars

2001-01-01

The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics.We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...

Satisfactory clinical outcome following delayed repositioning of a traumatic post-LASIK flap with dislocation and shrinkage managed by irrigation, stretching, and debridement*

Science.gov (United States)

Xu, Ye-sheng; Xie, Wen-jia; Yao, Yu-feng

2017-01-01

Objective: To report surgical management and favorable outcome in a case with delayed repair of traumatic laser in situ keratomileusis (LASIK) flap dislocation with shrinkage and folds. Methods: A 30-year-old man with a five-year history of bilateral LASIK experienced blunt trauma to his right eye followed by decreased vision for 5 weeks. The surgical management included initially softening the flap by irrigation with balanced salt solution (BSS). The shrinkage folds were carefully and gently stretched by scraping with a 26-gauge cannula accompanied by BSS irrigation. All of the epithelial ingrowth on the flap inner surface and on the bed was thoroughly debrided by scraping and irrigation. After the flap was repositioned to match its original margin, a soft bandage contact lens was placed. Results: At his initial visit, slit-lamp microscopy and optical coherence tomography (OCT) showed shrinkage of the LASIK flap with an elevated margin approximately 3 mm above the original position. The flap covered half of the pupil and had multiple horizontal folds. Two months after surgery, the flap remained well positioned with only faint streaks in the anterior stroma. The uncorrected visual acuity of the right eye was 20/20 with a manifest refraction of Plano. Conclusions: For delayed repair of traumatically dislocated LASIK flaps, sufficient softening by BSS, stretching the shrinkage folds, and thorough debridement of ingrowth epithelium enable resetting the flap and provide satisfactory results. PMID:28585430

Event-by-event simulation of quantum phenomena

NARCIS (Netherlands)

De Raedt, H.; Zhao, S.; Yuan, S.; Jin, F.; Michielsen, K.; Miyashita, S.

We discuss recent progress in the development of simulation algorithms that do not rely on any concept of quantum theory but are nevertheless capable of reproducing the averages computed from quantum theory through an event-by-event simulation. The simulation approach is illustrated by applications

Event-by-event simulation of quantum phenomena

NARCIS (Netherlands)

De Raedt, Hans; Michielsen, Kristel

A discrete-event simulation approach is reviewed that does not require the knowledge of the solution of the wave equation of the whole system, yet reproduces the statistical distributions of wave theory by generating detection events one-by-one. The simulation approach is illustrated by applications

Event display of a H -> 4e candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. Zoom into the tracking detector and the LAr calorimeter where its detailed structure is highlighted. The tracks and clusters of the two electron pairs are colored red and blue, respectively.

Joint Attributes and Event Analysis for Multimedia Event Detection.

Science.gov (United States)

Ma, Zhigang; Chang, Xiaojun; Xu, Zhongwen; Sebe, Nicu; Hauptmann, Alexander G

2017-06-15

Semantic attributes have been increasingly used the past few years for multimedia event detection (MED) with promising results. The motivation is that multimedia events generally consist of lower level components such as objects, scenes, and actions. By characterizing multimedia event videos with semantic attributes, one could exploit more informative cues for improved detection results. Much existing work obtains semantic attributes from images, which may be suboptimal for video analysis since these image-inferred attributes do not carry dynamic information that is essential for videos. To address this issue, we propose to learn semantic attributes from external videos using their semantic labels. We name them video attributes in this paper. In contrast with multimedia event videos, these external videos depict lower level contents such as objects, scenes, and actions. To harness video attributes, we propose an algorithm established on a correlation vector that correlates them to a target event. Consequently, we could incorporate video attributes latently as extra information into the event detector learnt from multimedia event videos in a joint framework. To validate our method, we perform experiments on the real-world large-scale TRECVID MED 2013 and 2014 data sets and compare our method with several state-of-the-art algorithms. The experiments show that our method is advantageous for MED.

Event display of a H -> 4e candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. The tracks and clusters of the two electron pairs are colored red and blue, respectively. The three displays on the right-hand side show the r-phi view of the event (top), a zoom into the vertex region, indicating that the 4 electrons originate from the same primary vertex (middle), and a Lego plot indicating the amount of transverse energy Et measured in the calorimeters (bottom).

Construction and updating of event models in auditory event processing.

Science.gov (United States)

Huff, Markus; Maurer, Annika E; Brich, Irina; Pagenkopf, Anne; Wickelmaier, Florian; Papenmeier, Frank

2018-02-01

Humans segment the continuous stream of sensory information into distinct events at points of change. Between 2 events, humans perceive an event boundary. Present theories propose changes in the sensory information to trigger updating processes of the present event model. Increased encoding effort finally leads to a memory benefit at event boundaries. Evidence from reading time studies (increased reading times with increasing amount of change) suggest that updating of event models is incremental. We present results from 5 experiments that studied event processing (including memory formation processes and reading times) using an audio drama as well as a transcript thereof as stimulus material. Experiments 1a and 1b replicated the event boundary advantage effect for memory. In contrast to recent evidence from studies using visual stimulus material, Experiments 2a and 2b found no support for incremental updating with normally sighted and blind participants for recognition memory. In Experiment 3, we replicated Experiment 2a using a written transcript of the audio drama as stimulus material, allowing us to disentangle encoding and retrieval processes. Our results indicate incremental updating processes at encoding (as measured with reading times). At the same time, we again found recognition performance to be unaffected by the amount of change. We discuss these findings in light of current event cognition theories. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Developing future precipitation events from historic events: An Amsterdam case study.

Science.gov (United States)

Manola, Iris; van den Hurk, Bart; de Moel, Hans; Aerts, Jeroen

2016-04-01

Due to climate change, the frequency and intensity of extreme precipitation events is expected to increase. It is therefore of high importance to develop climate change scenarios tailored towards the local and regional needs of policy makers in order to develop efficient adaptation strategies to reduce the risks from extreme weather events. Current approaches to tailor climate scenarios are often not well adopted in hazard management, since average changes in climate are not a main concern to policy makers, and tailoring climate scenarios to simulate future extremes can be complex. Therefore, a new concept has been introduced recently that uses known historic extreme events as a basis, and modifies the observed data for these events so that the outcome shows how the same event would occur in a warmer climate. This concept is introduced as 'Future Weather', and appeals to the experience of stakeholders and users. This research presents a novel method of projecting a future extreme precipitation event, based on a historic event. The selected precipitation event took place over the broader area of Amsterdam, the Netherlands in the summer of 2014, which resulted in blocked highways, disruption of air transportation, flooded buildings and public facilities. An analysis of rain monitoring stations showed that an event of such intensity has a 5 to 15 years return period. The method of projecting a future event follows a non-linear delta transformation that is applied directly on the observed event assuming a warmer climate to produce an "up-scaled" future precipitation event. The delta transformation is based on the observed behaviour of the precipitation intensity as a function of the dew point temperature during summers. The outcome is then compared to a benchmark method using the HARMONIE numerical weather prediction model, where the boundary conditions of the event from the Ensemble Prediction System of ECMWF (ENS) are perturbed to indicate a warmer climate. The two

PROFESSIONAL AND NONPROFESSIONAL EVENT MANAGERS: AGENTS’ CHARACTERISTICS OF EVENT-ACTIVITIES FIELD

Directory of Open Access Journals (Sweden)

Natalia Nikolaevna Startseva

2015-03-01

Full Text Available The main research question focuses on studying of the «new», non-traditional, recent forming professional group of event managers in modernRussia. This article provides the event group boundaries, its numerical and structural composition. On the basis of existing community event stereotypes, perceptions of event managers, supervisors’ event agencies and customers such the all agents included in the event activities, the author designed the image of professional and nonprofessional manager.Scientific, theoretical and practical significance of the work is leading to characterize agent-field-event activities and outline the prospects for the professional groups’ formation of event managers in modernRussia.Conceptuality and validity of the study is based on using theoretical and methodological comparative, functional and activity approaches.The obtained results can be used for further investigations in the event managers’ field and for other professional-groups, as well as useful in the study plan such as «Sociology of professions and professional groups» and «Sociology of culture and spiritual life».

Event display of a H -> 4mu candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 4mu candidate event with m(4l) = 124.1 (125.1) GeV without (with) Z mass constraint. The masses of the lepton pairs are 86.3 GeV and 31.6 GeV. The event was recorded by ATLAS on 10-Jun-2012, 13:24:31 CEST in run number 204769 as event number 71902630. Muon tracks are colored red. The inset on the right-hand side shows a zoom into the tracking detector. The inset on top shows a zoom into the vertex region, indicating that the 4 muons originate from the same primary vertex.

Probabilistic analysis of external events with focus on the Fukushima event

International Nuclear Information System (INIS)

Kollasko, Heiko; Jockenhoevel-Barttfeld, Mariana; Klapp, Ulrich

2014-01-01

External hazards are those natural or man-made hazards to a site and facilities that are originated externally to both the site and its processes, i.e. the duty holder may have very little or no control over the hazard. External hazards can have the potential of causing initiating events at the plant, typically transients like e.g., loss of offsite power. Simultaneously, external events may affect safety systems required to control the initiating event and, where applicable, also back-up systems implemented for risk-reduction. The plant safety may especially be threatened when loads from external hazards exceed the load assumptions considered in the design of safety-related systems, structures and components. Another potential threat is given by hazards inducing initiating events not considered in the safety demonstration otherwise. An example is loss of offsite power combined with prolonged plant isolation. Offsite support, e.g., delivery of diesel fuel oil, usually credited in the deterministic safety analysis may not be possible in this case. As the Fukushima events have shown, the biggest threat is likely given by hazards inducing both effects. Such hazards may well be dominant risk contributors even if their return period is very high. In order to identify relevant external hazards for a certain Nuclear Power Plant (NPP) location, a site specific screening analysis is performed, both for single events and for combinations of external events. As a result of the screening analysis, risk significant and therefore relevant (screened-in) single external events and combinations of them are identified for a site. The screened-in events are further considered in a detailed event tree analysis in the frame of the Probabilistic Safety Analysis (PSA) to calculate the core damage/large release frequency resulting from each relevant external event or from each relevant combination. Screening analyses of external events performed at AREVA are based on the approach provided

Event display of a H -> 4e candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display (side view) of a H -> 4e candidate event with m(4l) = 124.5 (124.6) GeV without (with) Z mass constraint. The masses of the lepton pairs are 70.6 GeV and 44.7 GeV. The event was recorded by ATLAS on 18-May-2012, 20:28:11 CEST in run number 203602 as event number 82614360. The tracks of the two electron pairs are colored red and blue, respectively. Electron clusters in the LAr calorimeter are colored darkgreen. The three displays on the right-hand side show the r-phi view of the event (top), a zoom into the vertex region, indicating that the 4 electrons originate from the same primary vertex (middle), and a Lego plot indicating the amount of transverse energy Et measured in the calorimeters (bottom).

Event segmentation improves event memory up to one month later.

Science.gov (United States)

Flores, Shaney; Bailey, Heather R; Eisenberg, Michelle L; Zacks, Jeffrey M

2017-08-01

When people observe everyday activity, they spontaneously parse it into discrete meaningful events. Individuals who segment activity in a more normative fashion show better subsequent memory for the events. If segmenting events effectively leads to better memory, does asking people to attend to segmentation improve subsequent memory? To answer this question, participants viewed movies of naturalistic activity with instructions to remember the activity for a later test, and in some conditions additionally pressed a button to segment the movies into meaningful events or performed a control condition that required button-pressing but not attending to segmentation. In 5 experiments, memory for the movies was assessed at intervals ranging from immediately following viewing to 1 month later. Performing the event segmentation task led to superior memory at delays ranging from 10 min to 1 month. Further, individual differences in segmentation ability predicted individual differences in memory performance for up to a month following encoding. This study provides the first evidence that manipulating event segmentation affects memory over long delays and that individual differences in event segmentation are related to differences in memory over long delays. These effects suggest that attending to how an activity breaks down into meaningful events contributes to memory formation. Instructing people to more effectively segment events may serve as a potential intervention to alleviate everyday memory complaints in aging and clinical populations. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Event by event physics in ALICE

CERN Document Server

Christakoglou, Panos

2009-01-01

Fluctuations of thermodynamic quantities are fundamental for the study of the QGP phase transition. The ALICE experiment is well suited for precise event-by-event measurements of various quantities. In this article, we review the capabilities of ALICE to study the fluctuations of several key observables such as the net charge, the temperature, and the particle ratios. Among the observables related to correlations, we review the balance functions and the long range correlations.

Charge-dependent correlations from event-by-event anomalous hydrodynamics

Energy Technology Data Exchange (ETDEWEB)

Hirono, Yuji [Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794-3800 (United States); Hirano, Tetsufumi [Department of Physics, Sophia University, Tokyo 102-8554 (Japan); Kharzeev, Dmitri E. [Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794-3800 (United States); Department of Physics and RIKEN-BNL Research Center, Brookhaven National Laboratory, Upton, NY 11973-5000 (United States)

2016-12-15

We report on our recent attempt of quantitative modeling of the Chiral Magnetic Effect (CME) in heavy-ion collisions. We perform 3+1 dimensional anomalous hydrodynamic simulations on an event-by-event basis, with constitutive equations that contain the anomaly-induced effects. We also develop a model of the initial condition for the axial charge density that captures the statistical nature of random chirality imbalances created by the color flux tubes. Basing on the event-by-event hydrodynamic simulations for hundreds of thousands of collisions, we calculate the correlation functions that are measured in experiments, and discuss how the anomalous transport affects these observables.

Subchromosomal karyotype evolution in Equidae.

Science.gov (United States)

Musilova, P; Kubickova, S; Vahala, J; Rubes, J

2013-04-01

Equidae is a small family which comprises horses, African and Asiatic asses, and zebras. Despite equids having diverged quite recently, their karyotypes underwent rapid evolution which resulted in extensive differences among chromosome complements in respective species. Comparative mapping using whole-chromosome painting probes delineated genome-wide chromosome homologies among extant equids, enabling us to trace chromosome rearrangements that occurred during evolution. In the present study, we performed subchromosomal comparative mapping among seven Equidae species, representing the whole family. Region-specific painting and bacterial artificial chromosome probes were used to determine the orientation of evolutionarily conserved segments with respect to centromere positions. This allowed assessment of the configuration of all fusions occurring during the evolution of Equidae, as well as revealing discrepancies in centromere location caused by centromere repositioning or inversions. Our results indicate that the prevailing type of fusion in Equidae is centric fusion. Tandem fusions of the type telomere-telomere occur almost exclusively in the karyotype of Hartmann's zebra and are characteristic of this species' evolution. We revealed inversions in segments homologous to horse chromosomes 3p/10p and 13 in zebras and confirmed inversions in segments 4/31 in African ass, 7 in horse and 8p/20 in zebras. Furthermore, our mapping results suggested that centromere repositioning events occurred in segments homologous to horse chromosomes 7, 8q, 10p and 19 in the African ass and an element homologous to horse chromosome 16 in Asiatic asses. Centromere repositioning in chromosome 1 resulted in three different chromosome types occurring in extant species. Heterozygosity of the centromere position of this chromosome was observed in the kiang. Other subtle changes in centromere position were described in several evolutionary conserved chromosomal segments, suggesting that tiny

Event by event fluctuations in heavy ion collisions

Energy Technology Data Exchange (ETDEWEB)

Koch, Volker

2001-01-01

The authors discuss the physics underlying event-by-event fluctuations in relativistic heavy ion collisions. We will argue that the fluctuations of the ratio of positively over negatively charged particles may serve as a unique signature for the Quark Gluon Plasma.

Estabilidade do reposicionamento anterior da maxila através de análise cefalométrica lateral Lateral cephalometric analysis of the stability of maxillary anterior repositioning

Directory of Open Access Journals (Sweden)

Rodrygo Nunes Tavares

2005-06-01

Full Text Available Este estudo cefalométrico retrospectivo foi proposto objetivando analisar a estabilidade do reposicionamento anterior da maxila, utilizando-se a osteotomia Le Fort I. A amostra consistiu de 30 telerradiografias de dez pacientes submetidos a um avanço cirúrgico da maxila, sem segmentação desta ou associação com qualquer cirurgia na mandíbula, realizado pela Área de Cirurgia Buco-Maxilo-Facial da Faculdade de Odontologia de Piracicaba - Unicamp. A mesma técnica de fixação interna rígida foi utilizada para todos os pacientes, e nenhum enxerto ou substituto ósseo foi usado. Três radiografias cefalométricas laterais foram realizadas para cada paciente, nos períodos pré e pós-operatórios imediatos, e com, no mínimo, seis meses após a cirurgia. Sobre estas radiografias foram feitas linhas de referência horizontal e vertical. Os pontos cefalométricos utilizados para calcular as mudanças de posição da maxila foram tanto esqueléticos, quanto dentários. A análise estatística (teste t de student pareado não demonstrou diferença estatística significante entre os intervalos pós-operatórios imediato e com no mínimo seis meses. Concluímos que o reposicionamento anterior da maxila, utilizando-se a osteotomia Le Fort I, com fixação interna rígida e sem o uso de enxertos autógenos ou qualquer substituto ósseo, é um procedimento estável.This is a retrospective cephalometric study designed to investigate the stability after anterior maxilla repositioning, by Le Fort I osteotomy. Thirty cephalometric radiographs were selected, from ten patients submitted to one-piece surgical maxillary advancement, with no concomitant mandibular surgery, performed by the Division of Oral and Maxillofacial Surgery of Piracicaba Dental School - Unicamp. These cases were submitted to the same internal rigid fixation technique, with no use of bone grafts or any bone substitute. Three lateral cephalometric radiographs were obtained for each

Topology of Event Horizon

OpenAIRE

Siino, Masaru

1997-01-01

The topologies of event horizons are investigated. Considering the existence of the endpoint of the event horizon, it cannot be differentiable. Then there are the new possibilities of the topology of the event horizon though they are excluded in smooth event horizons. The relation between the topology of the event horizon and the endpoint of it is revealed. A torus event horizon is caused by two-dimensional endpoints. One-dimensional endpoints provide the coalescence of spherical event horizo...

High Precision Edge Detection Algorithm for Mechanical Parts

Directory of Open Access Journals (Sweden)

Duan Zhenyun

2018-04-01

Full Text Available High precision and high efficiency measurement is becoming an imperative requirement for a lot of mechanical parts. So in this study, a subpixel-level edge detection algorithm based on the Gaussian integral model is proposed. For this purpose, the step edge normal section line Gaussian integral model of the backlight image is constructed, combined with the point spread function and the single step model. Then gray value of discrete points on the normal section line of pixel edge is calculated by surface interpolation, and the coordinate as well as gray information affected by noise is fitted in accordance with the Gaussian integral model. Therefore, a precise location of a subpixel edge was determined by searching the mean point. Finally, a gear tooth was measured by M&M3525 gear measurement center to verify the proposed algorithm. The theoretical analysis and experimental results show that the local edge fluctuation is reduced effectively by the proposed method in comparison with the existing subpixel edge detection algorithms. The subpixel edge location accuracy and computation speed are improved. And the maximum error of gear tooth profile total deviation is 1.9 μm compared with measurement result with gear measurement center. It indicates that the method has high reliability to meet the requirement of high precision measurement.

Event Segmentation Improves Event Memory up to One Month Later

Science.gov (United States)

Flores, Shaney; Bailey, Heather R.; Eisenberg, Michelle L.; Zacks, Jeffrey M.

2017-01-01

When people observe everyday activity, they spontaneously parse it into discrete meaningful events. Individuals who segment activity in a more normative fashion show better subsequent memory for the events. If segmenting events effectively leads to better memory, does asking people to attend to segmentation improve subsequent memory? To answer…

Vitrectomía pars plana y reimplante de lente intraocular en surco Pars plana vitrectomy and intraocular lens repositioning in the sulcus

Directory of Open Access Journals (Sweden)

Alejandro Guerra García

2010-01-01

Full Text Available Se presentó un caso de lente intraocular luxado a vítreo en paciente con conteo bajo de células endoteliales e intolerancia a lentes de contacto. Se practicó vitrectomía pars plana con reimplante de lente en surco ciliar con el objetivo de demostrar la fiabilidad de la técnica para casos que presenten condiciones adecuadas y situaciones especiales. Se revisó la bibliografía para conocer las tendencias actuales con respecto al manejo de esta patología. El paciente alcanzó una agudeza visual de 20/30. El lente permaneció estable en el surco 3 meses después de practicada la vitrectomía. El manejo de esta entidad debe ser personalizado. La técnica utilizada debe ser siempre la primera opción de tratamiento y parece ser segura en casos cuidadosamente escogidos.A case of dislocated intraocular lens moved to the vitreous cavity in a patient with low endothelial cell count and contact lens intolerance was reported. A pars plana vitrectomy with lens repositioning was performed to demonstrate the safety of this technique for some special cases under adequate conditions. The literature was reviewed to learn about the current management of this pathology. Finally, patient's best visual acuity was 20/30. The stability of the lens was confirmed three month l after the vitrectomy. Management of this disorder should be customized. This technique should be considered as the first option of treatment and seems to be safe in selected cases.

Event-Based Conceptual Modeling

DEFF Research Database (Denmark)

Bækgaard, Lars

2009-01-01

The purpose of the paper is to obtain insight into and provide practical advice for event-based conceptual modeling. We analyze a set of event concepts and use the results to formulate a conceptual event model that is used to identify guidelines for creation of dynamic process models and static...... information models. We characterize events as short-duration processes that have participants, consequences, and properties, and that may be modeled in terms of information structures. The conceptual event model is used to characterize a variety of event concepts and it is used to illustrate how events can...... be used to integrate dynamic modeling of processes and static modeling of information structures. The results are unique in the sense that no other general event concept has been used to unify a similar broad variety of seemingly incompatible event concepts. The general event concept can be used...

Event-by-event fluctuations in the medium-induced jet evolution

International Nuclear Information System (INIS)

Escobedo, Miguel A.; Iancu, Edmond

2016-01-01

We develop the event-by-event picture of the gluon distribution produced via medium-induced gluon branching by an energetic jet which propagates through a dense QCD medium. A typical event is characterized by the production of a large number of soft gluons which propagate at large angles with respect to the jet axis and which collectively carry a substantial amount of energy. By explicitly computing 2-gluon correlations, we demonstrate the existence of large event-by-event fluctuations, which reflect the stochastic nature of the branching process. For the two quantities that we have investigated — the energy loss at large angles and the soft gluon multiplicity —, the dispersion is parametrically as large as the respective expectation value. We identify interesting scaling laws, which suggest that the multiplicity distribution should exhibit KNO (Koba-Nielsen-Olesen) scaling. A similar scaling is known to hold for a jet branching in the vacuum, but the medium-induced distribution is found to be considerably broader. We predict that event-by-event measurements of the di-jet asymmetry in Pb+Pb collisions at the LHC should observe large fluctuations in the number of soft hadrons propagating at large angles and also in the total energy carried by these hadrons.

Purchase decision involvement: Event management segments and related event behavior

Science.gov (United States)

Rodney B. Warnick; David C. Bojanic

2012-01-01

The goal of this research was to examine the relationships between different levels of event purchase decision involvement (PDI) segments and their respective event behaviors (e.g., expenditures, travel behavior, event consumption and satisfaction). The specific purpose was to answer two major research questions: 1) Can PDI identify different levels or segments of...

ICPP criticality event of October 17, 1978. Facts and sequential description of criticality event and precursor events

International Nuclear Information System (INIS)

1979-01-01

On October 17 during the period of approximately 8:15 to 8:40 p.m., a criticality event occurred in the base of IB column, H-100. The inventory of medium short-lived fission products used to determine the number of fissions indicates that the criticality occurred in column H-100 aqueous phase and the sampling of the column wall with counting of the filings clearly indicates that the event occurred in the column base. The events leading up to the accident are described. The event produced no personnel injury, on-or off-site contamination, nor damage to equipment or property

A network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes.

Science.gov (United States)

Cheng, Feixiong; Zhao, Junfei; Fooksa, Michaela; Zhao, Zhongming

2016-07-01

Development of computational approaches and tools to effectively integrate multidomain data is urgently needed for the development of newly targeted cancer therapeutics. We proposed an integrative network-based infrastructure to identify new druggable targets and anticancer indications for existing drugs through targeting significantly mutated genes (SMGs) discovered in the human cancer genomes. The underlying assumption is that a drug would have a high potential for anticancer indication if its up-/down-regulated genes from the Connectivity Map tended to be SMGs or their neighbors in the human protein interaction network. We assembled and curated 693 SMGs in 29 cancer types and found 121 proteins currently targeted by known anticancer or noncancer (repurposed) drugs. We found that the approved or experimental cancer drugs could potentially target these SMGs in 33.3% of the mutated cancer samples, and this number increased to 68.0% by drug repositioning through surveying exome-sequencing data in approximately 5000 normal-tumor pairs from The Cancer Genome Atlas. Furthermore, we identified 284 potential new indications connecting 28 cancer types and 48 existing drugs (adjusted P < .05), with a 66.7% success rate validated by literature data. Several existing drugs (e.g., niclosamide, valproic acid, captopril, and resveratrol) were predicted to have potential indications for multiple cancer types. Finally, we used integrative analysis to showcase a potential mechanism-of-action for resveratrol in breast and lung cancer treatment whereby it targets several SMGs (ARNTL, ASPM, CTTN, EIF4G1, FOXP1, and STIP1). In summary, we demonstrated that our integrative network-based infrastructure is a promising strategy to identify potential druggable targets and uncover new indications for existing drugs to speed up molecularly targeted cancer therapeutics. © The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. All

Abordagens, estratégias e ferramentas para o acesso aberto via periódicos e repositórios institucionais em instituições acadêmicas brasileiras | Approaches, strategies and tools for open access through journals and institutional repositories in Brazilian

Directory of Open Access Journals (Sweden)

Sely Costa

2008-09-01

Full Text Available Resumo Este ensaio tem por objetivo discutir, de modo sucinto, o movimento do acesso aberto nos dias atuais, procurando-se identificar a diferença entre acesso aberto à literatura científica e acesso aberto ao conhecimento científico. A abordagem do acesso aberto à literatura relaciona-se com o processo de comunicação, enquanto o acesso aberto ao conhecimento científico, com a gestão do conhecimento. Recorre-se à literatura e à experiência pessoal no intuito de identificar e relatar estratégias e ferramentas que têm sido utilizadas em diferentes países e no próprio Brasil. A discussão fundamenta-se em três tópicos considerados basilares para o estudo e a prática com periódicos eletrônicos e repositórios de acesso aberto, que são: as diferenças disciplinares, o sistema de comunicação científica e os modelos de gestão do conhecimento. Parte-se do pressuposto de que as diferenças disciplinares devem nortear as ações e decisões a respeito da criação e manutenção de revistas e repositórios. As primeiras, como veículos efetivos de comunicação científica. Os últimos, como, ferramentas eficientes de gestão do conhecimento. Palavras-chave acesso aberto à literatura científica; acesso aberto ao conhecimento científico; periódicos científicos eletrônicos de acesso aberto; repositórios institucionais; diferenças disciplinares; modelo de comunicação científica; modelo de gestão do conhecimento científico. Abstract This essay aims at briefly discussing the open access movement today, trying to identify the difference between open access to scientific literature and open access to scientific knowledge. Open access to scientific literature is related to the scholarly communication process approach, while open access to scientific knowledge concerns the knowledge management approach. Both the literature and personal experience are used as the basis for discussion, attempting to identify and report

Event-Based Conceptual Modeling

DEFF Research Database (Denmark)

Bækgaard, Lars

The paper demonstrates that a wide variety of event-based modeling approaches are based on special cases of the same general event concept, and that the general event concept can be used to unify the otherwise unrelated fields of information modeling and process modeling. A set of event......-based modeling approaches are analyzed and the results are used to formulate a general event concept that can be used for unifying the seemingly unrelated event concepts. Events are characterized as short-duration processes that have participants, consequences, and properties, and that may be modeled in terms...... of information structures. The general event concept can be used to guide systems analysis and design and to improve modeling approaches....

Trunk proprioception adaptations to creep deformation.

Science.gov (United States)

Abboud, Jacques; Rousseau, Benjamin; Descarreaux, Martin

2018-01-01

This study aimed at identifying the short-term effect of creep deformation on the trunk repositioning sense. Twenty healthy participants performed two different trunk-repositioning tasks (20° and 30° trunk extension) before and after a prolonged static full trunk flexion of 20 min in order to induce spinal tissue creep. Trunk repositioning error variables, trunk movement time and erector spinae muscle activity were computed and compared between the pre- and post-creep conditions. During the pre-creep condition, significant increases in trunk repositioning errors, as well as trunk movement time, were observed in 30° trunk extension in comparison to 20°. During the post-creep condition, trunk repositioning errors variables were significantly increased only when performing a 20° trunk extension. Erector spinae muscle activity increased in the post-creep condition, while it remained unchanged between trunk repositioning tasks. Trunk repositioning sense seems to be altered in the presence of creep deformation, especially in a small range of motion. Reduction of proprioception acuity may increase the risk of spinal instability, which is closely related to the risk of low back pain or injury.

Safeguards summary event list (SSEL)

International Nuclear Information System (INIS)

Davidson, J.J.; MacMurdy, P.H.

1980-12-01

The List contains nine categories of events involving NRC licensed material or licensees. It is deliberately broad in scope for two main reasons. First, the list is designed to serve as a reference document. It is as complete and accurate as possible. Second, the list is intended to provide as broad a perspective of the nature of licensee-related events as possible. The nine categories of events are as follows: bomb-related events; intrusion events; missing and/or allegedly stolen events; transportation-related events; vandalism events; arson events; firearms-related events; sabotage events; and miscellaneous events

Event-By-Event Initial Conditions for Heavy Ion Collisions

International Nuclear Information System (INIS)

Rose, S; Fries, R J

2017-01-01

The early time dynamics of heavy ion collisions can be described by classical fields in an approximation of Quantum ChromoDynamics (QCD) called Color Glass Condensate (CGC). Monte-Carlo sampling of the color charge for the incoming nuclei are used to calculate their classical gluon fields. Following the recent work by Chen et al. we calculate the energy momentum tensor of those fields at early times in the collision event-by-event. This can then be used for subsequent hydrodynamic evolution of the single events. (paper)

Event-By-Event Initial Conditions for Heavy Ion Collisions

Science.gov (United States)

Rose, S.; Fries, R. J.

2017-04-01

The early time dynamics of heavy ion collisions can be described by classical fields in an approximation of Quantum ChromoDynamics (QCD) called Color Glass Condensate (CGC). Monte-Carlo sampling of the color charge for the incoming nuclei are used to calculate their classical gluon fields. Following the recent work by Chen et al. we calculate the energy momentum tensor of those fields at early times in the collision event-by-event. This can then be used for subsequent hydrodynamic evolution of the single events.

Episodes, events, and models

Directory of Open Access Journals (Sweden)

Sangeet eKhemlani

2015-10-01

Full Text Available We describe a novel computational theory of how individuals segment perceptual information into representations of events. The theory is inspired by recent findings in the cognitive science and cognitive neuroscience of event segmentation. In line with recent theories, it holds that online event segmentation is automatic, and that event segmentation yields mental simulations of events. But it posits two novel principles as well: first, discrete episodic markers track perceptual and conceptual changes, and can be retrieved to construct event models. Second, the process of retrieving and reconstructing those episodic markers is constrained and prioritized. We describe a computational implementation of the theory, as well as a robotic extension of the theory that demonstrates the processes of online event segmentation and event model construction. The theory is the first unified computational account of event segmentation and temporal inference. We conclude by demonstrating now neuroimaging data can constrain and inspire the construction of process-level theories of human reasoning.

A Mosque event

DEFF Research Database (Denmark)

Simonsen, Kirsten; Neergaard, Maja de; Koefoed, Lasse Martin

2017-01-01

and public imaginations attached to it. And they are connected to a specific event – the opening of the mosque. In the first part, a conceptual framework is presented bringing together literature on three notions: encounters, visibility and the event. Following this, the paper explores the opening event...

The global event system

International Nuclear Information System (INIS)

Winans, J.

1994-01-01

The support for the global event system has been designed to allow an application developer to control the APS event generator and receiver boards. This is done by the use of four new record types. These records are customized and are only supported by the device support modules for the APS event generator and receiver boards. The use of the global event system and its associated records should not be confused with the vanilla EPICS events and the associated event records. They are very different

Causal events enter awareness faster than non-causal events

Directory of Open Access Journals (Sweden)

Pieter Moors

2017-01-01

Full Text Available Philosophers have long argued that causality cannot be directly observed but requires a conscious inference (Hume, 1967. Albert Michotte however developed numerous visual phenomena in which people seemed to perceive causality akin to primary visual properties like colour or motion (Michotte, 1946. Michotte claimed that the perception of causality did not require a conscious, deliberate inference but, working over 70 years ago, he did not have access to the experimental methods to test this claim. Here we employ Continuous Flash Suppression (CFS—an interocular suppression technique to render stimuli invisible (Tsuchiya & Koch, 2005—to test whether causal events enter awareness faster than non-causal events. We presented observers with ‘causal’ and ‘non-causal’ events, and found consistent evidence that participants become aware of causal events more rapidly than non-causal events. Our results suggest that, whilst causality must be inferred from sensory evidence, this inference might be computed at low levels of perceptual processing, and does not depend on a deliberative conscious evaluation of the stimulus. This work therefore supports Michotte’s contention that, like colour or motion, causality is an immediate property of our perception of the world.

Event planning the ultimate guide to successful meetings, corporate events, fundraising galas, conferences, conventions, incentives and other special events

CERN Document Server

Allen, Judy

2009-01-01

This bestselling all–in–one guide to the event planning business is back and better than ever, fully updated and revised to reflect the very latest trends and best practices in the industry. This handy, comprehensive guide includes forms, checklists, and tips for managing events, as well as examples and case studies of both successful and unsuccessful events. Judy Allen (Toronto, ON, Canada) is founder and President of Judy Allen Productions, a full–service event planning production company.

Event-by-Event Observables and Fluctuations

International Nuclear Information System (INIS)

Petersen, Hannah

2013-01-01

In this talk the status and open questions of the phenomenological description of all the stages of a heavy ion reaction are highlighted. Special emphasis is put on event-by-event fluctuations and associated observables. The first part is concentrated on high RHIC and LHC energies and the second part reviews the challenges for modeling heavy ion reactions at lower beam energies in a more realistic fashion. Overall, the main conclusion is that sophisticated theoretical dynamical approaches that describe many observables in the same framework are essential for the quantitative understanding of the properties of hot and dense nuclear matter

Dynamics of Charged Events

International Nuclear Information System (INIS)

Bachas, Constantin; Bunster, Claudio; Henneaux, Marc

2009-01-01

In three spacetime dimensions the world volume of a magnetic source is a single point, an event. We make the event dynamical by regarding it as the imprint of a flux-carrying particle impinging from an extra dimension. This can be generalized to higher spacetime dimensions and to extended events. We exhibit universal observable consequences of the existence of events and argue that events are as important as particles or branes. We explain how events arise on the world volume of membranes in M theory, and in a Josephson junction in superconductivity.

ATLAS event at 13 TeV - Multijet Exotics Search Event Display - 2015 data

CERN Multimedia

ATLAS Collaboration

2015-01-01

Run 279984, Event 1079767163 A 10 jet event selected in the search for strong gravity in multijet final states (CERN-PH-EP-2015-312). The scalar sum of jet transverse momenta (HT) of the event is 4.4 TeV. Run 282712, Event 474587238 The event with the largest scalar sum of jet transverse momenta (HT) selected in the search for strong gravity in multijet final states (CERN-PH-EP-2015-312). The HT of the event is 6.4 TeV.

Event display of a H -> 2e2mu candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 2e2mu candidate event with m(4l) = 122.6 (123.9) GeV without (with) Z mass constraint. The masses of the lepton pairs are 87.9 GeV and 19.6 GeV. The event was recorded by ATLAS on 18-Jun-2012, 11:07:47 CEST in run number 205113 as event number 12611816. Zoom into the tracking detector. Muon tracks are colored red, electron tracks and clusters in the LAr calorimeter are colored green.

Initiating events frequency determination

International Nuclear Information System (INIS)

Simic, Z.; Mikulicic, V.; Vukovic, I.

2004-01-01

The paper describes work performed for the Nuclear Power Station (NPS). Work is related to the periodic initiating events frequency update for the Probabilistic Safety Assessment (PSA). Data for all relevant NPS initiating events (IE) were reviewed. The main focus was on events occurring during most recent operating history (i.e., last four years). The final IE frequencies were estimated by incorporating both NPS experience and nuclear industry experience. Each event was categorized according to NPS individual plant examination (IPE) initiating events grouping approach. For the majority of the IE groups, few, or no events have occurred at the NPS. For those IE groups with few or no NPS events, the final estimate was made by means of a Bayesian update with general nuclear industry values. Exceptions are rare loss-of-coolant-accidents (LOCA) events, where evaluation of engineering aspects is used in order to determine frequency.(author)

Surface electromyographic patterns of masticatory, neck, and trunk muscles in temporomandibular joint dysfunction patients undergoing anterior repositioning splint therapy.

Science.gov (United States)

Tecco, Simona; Tetè, Stefano; D'Attilio, Michele; Perillo, Letizia; Festa, Felice

2008-12-01

The aim of this study was to investigate the surface electromyographic (sEMG) activity of neck, trunk, and masticatory muscles in subjects with temporomandibular joint (TMJ) internal derangement treated with anterior mandibular repositioning splints. sEMG activities of the muscles in 34 adult subjects (22 females and 12 males; mean age 30.4 years) with TMJ internal derangement were compared with a control group of 34 untreated adults (20 females and 14 males; mean age 31.8 years). sEMG activities of seven muscles (anterior and posterior temporalis, masseter, posterior cervicals, sternocleidomastoid, and upper and lower trapezius) were studied bilaterally, with the mandible in the rest position and during maximal voluntary clenching (MVC), at the beginning of therapy (T0) and after 10 weeks of treatment (T1). Paired and Student's t-tests were undertaken to determine differences between the T0 and T1 data and in sEMG activity between the study and control groups. At T0, paired masseter, sternocleidomastoid, and cervical muscles, in addition to the left anterior temporal and right lower trapezius, showed significantly greater sEMG activity (P = 0.0001; P = 0.0001; for left cervical, P = 0.03; for right cervical, P = 0.0001; P = 0.006 and P = 0.007 muscles, respectively) compared with the control group. This decreased over the remaining study period, such that after treatment, sEMG activity revealed no statistically significant difference when compared with the control group. During MVC at T0, paired masseter and anterior and posterior temporalis muscles showed significantly lower sEMG activity (P = 0.03; P = 0.005 and P = 0.04, respectively) compared with the control group. In contrast, at T1 sEMG activity significantly increased (P = 0.02; P = 0.004 and P = 0.04, respectively), but no difference was observed in relation to the control group. Splint therapy in subjects with internal disk derangement seems to affect sEMG activity of the masticatory, neck, and trunk

On semirecurrent events

International Nuclear Information System (INIS)

Dvurechenskij, A.

1984-01-01

In some problems of the mathematical theory of particle counters, film or filmless measurements of track ionization in high energy physics,queueing theory, random walks, etc., the classes of emirecurrent and m-semirecurrent events, which generalize the recurrent events and the recurrent events with delay, appeared. In the paper their basic properties, and some relationships between them are shown

Event management for large scale event-driven digital hardware spiking neural networks.

Science.gov (United States)

Caron, Louis-Charles; D'Haene, Michiel; Mailhot, Frédéric; Schrauwen, Benjamin; Rouat, Jean

2013-09-01

The interest in brain-like computation has led to the design of a plethora of innovative neuromorphic systems. Individually, spiking neural networks (SNNs), event-driven simulation and digital hardware neuromorphic systems get a lot of attention. Despite the popularity of event-driven SNNs in software, very few digital hardware architectures are found. This is because existing hardware solutions for event management scale badly with the number of events. This paper introduces the structured heap queue, a pipelined digital hardware data structure, and demonstrates its suitability for event management. The structured heap queue scales gracefully with the number of events, allowing the efficient implementation of large scale digital hardware event-driven SNNs. The scaling is linear for memory, logarithmic for logic resources and constant for processing time. The use of the structured heap queue is demonstrated on a field-programmable gate array (FPGA) with an image segmentation experiment and a SNN of 65,536 neurons and 513,184 synapses. Events can be processed at the rate of 1 every 7 clock cycles and a 406×158 pixel image is segmented in 200 ms. Copyright © 2013 Elsevier Ltd. All rights reserved.

Events as spaces for upgrading : Automotive events in Shanghai

NARCIS (Netherlands)

E. van Tuijl (Erwin); K. Dittrich (Koen)

2015-01-01

textabstractThis study contributes to the literature dealing with upgrading of the Chinese automotive industry by analysing the role of events in the upgrading process. By combining literature on temporary clusters with that of knowledge sourcing and upgrading, we investigate how firms use events

Features, Events, and Processes: Disruptive Events

International Nuclear Information System (INIS)

P. Sanchez

2004-01-01

The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA)

Features, Events, and Processes: Disruptive Events

Energy Technology Data Exchange (ETDEWEB)

P. Sanchez

2004-11-08

The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA).

Sensitivity studies on the approaches for addressing multiple initiating events in fire events PSA

Energy Technology Data Exchange (ETDEWEB)

Kang, Dae Il; Lim, Ho Gon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

A single fire event within a fire compartment or a fire scenario can cause multiple initiating events (IEs). As an example, a fire in a turbine building fire area can cause a loss of the main feed-water (LOMF) and loss of off-site power (LOOP) IEs. Previous domestic fire events PSA had considered only the most severe initiating event among multiple initiating events. NUREG/CR-6850 and ANS/ASME PRA Standard require that multiple IEs are to be addressed in fire events PSA. In this paper, sensitivity studies on the approaches for addressing multiple IEs in fire events PSA for Hanul Unit 3 were performed and their results were presented. In this paper, sensitivity studies on the approaches for addressing multiple IEs in fire events PSA are performed and their results were presented. From the sensitivity analysis results, we can find that the incorporations of multiple IEs into fire events PSA model result in the core damage frequency (CDF) increase and may lead to the generation of the duplicate cutsets. Multiple IEs also can occur at internal flooding event or other external events such as seismic event. They should be considered in the constructions of PSA models in order to realistically estimate risk due to flooding or seismic events.

Event-by-event particle multiplicity fluctuations in Pb-Pb collisions with ALICE

Energy Technology Data Exchange (ETDEWEB)

Arslandok, Mesut [Institut fuer Kernphysik, Goethe-Universitaet Frankfurt (Germany); Collaboration: ALICE-Collaboration

2014-07-01

The study of event-by-event fluctuations of identified hadrons may reveal the degrees of freedom of the strongly interacting mater created in heavy-ion collisions. Particle identification that is based on the measurement of the specific ionization energy loss dE/dx works well on a statistical basis, however, suffers from ambiguities when applied on the event-by-event level. A novel experimental technique called the ''Identity Method'' was recently proposed to overcome such limitations. The method follows a probabilistic approach using the inclusive dE/dx distributions measured in the ALICE TPC, and determines the moments of the multiplicity distributions by an unfolding procedure. In this contribution, the status of an event-by-event fluctuation analysis that applies the Identity Method to Pb-Pb data from ALICE is presented.

A safe-repositioning maneuver for the management of benign paroxysmal positional vertigo: Gans vs. Epley maneuver; a randomized comparative clinical trial.

Science.gov (United States)

Saberi, Alia; Nemati, Shadman; Sabnan, Salah; Mollahoseini, Fatemeh; Kazemnejad, Ehsan

2017-08-01

Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral vertigo. Some repositioning maneuvers have been described for its management. The aim of this study was comparing the therapeutic effect of Epley and Gans maneuvers in BPPV. This randomized clinical trial was performed from September to December 2015. 73 patients with true vertigo diagnosed as BPPV enrolled the study. They randomly assigned in quadripartite blocks to modified Epley maneuver group (E) or Gans maneuver group (G). 1 day and 1 week after intervention, the objective and subjective responses to treatment were assessed. Statistical analysis was performed using the Chi-square test and regression model in the SPSS software version 21. Thirty patients enrolled each group with a mean age of 46.9 ± 13.4 (E group) and 46.7 ± 7.5 year (G group). 23.3 % of E group and 26.7 % of G group were men (p = 0.766). In E and G groups in the first day, subjective outcomes revealed 86.7 and 60 % rate of success (p = 0.02); and 86.7 and 56.7 % of patients exhibited objective improvement, respectively (p = 0.01). After 1 week, the subjective and objective outcomes revealed improvement among 70 % of E group and 46.7 % of G group (p = 0.067). The only complication with significant difference was cervical pain with a higher rate in E group (23.3 vs. 0.0 %, p = 0.005). These results revealed the similar long-term efficacy of Epley and Gans maneuver for the treatment of BPPV. Cervical pain was most frequent complication of Epley maneuver.

Event Coverage Detection and Event Source Determination in Underwater Wireless Sensor Networks

Directory of Open Access Journals (Sweden)

Zhangbing Zhou

2015-12-01

Full Text Available With the advent of the Internet of Underwater Things, smart things are deployed in the ocean space and establish underwater wireless sensor networks for the monitoring of vast and dynamic underwater environments. When events are found to have possibly occurred, accurate event coverage should be detected, and potential event sources should be determined for the enactment of prompt and proper responses. To address this challenge, a technique that detects event coverage and determines event sources is developed in this article. Specifically, the occurrence of possible events corresponds to a set of neighboring sensor nodes whose sensory data may deviate from a normal sensing range in a collective fashion. An appropriate sensor node is selected as the relay node for gathering and routing sensory data to sink node(s. When sensory data are collected at sink node(s, the event coverage is detected and represented as a weighted graph, where the vertices in this graph correspond to sensor nodes and the weight specified upon the edges reflects the extent of sensory data deviating from a normal sensing range. Event sources are determined, which correspond to the barycenters in this graph. The results of the experiments show that our technique is more energy efficient, especially when the network topology is relatively steady.

A system for diagnostic quality radiographic alignment of radiotherapy patients

International Nuclear Information System (INIS)

Gall, Kenneth P.; Zygmanski, Piotr; Thornton, Allan F.

1996-01-01

Purpose In order to achieve highly accurate positioning of radiotherapy patients treated on a standard fractionation schedule we have developed a digital imaging system and associated repositioning algorithms. The system is efficient enough that it is usable on a routine basis. The system is intended to allow stereotactic level precision of patient positioning in fractionated therapy which in turn allows treatment fields to be designed with tighter margins. This may allow higher target doses to be delivered and thereby higher local control to be achieved for certain classes of patients. Materials and Methods Patients to be treated under a standard fractionation schedule for intracranial or head and neck targets have a set of three radiopaque fiducial markers implanted in the outer table of the skull. As part of the 3 dimensional treatment plan the locations of the fiducial markers is determined on the planning CT scan. The positions of the markers relative to the beam direction and isocenter constitute a 3 dimensional position prescription for the treatment. At the time of treatment a pair of orthogonal images is obtained with diagnostic xray tubes aligned to isocenter and a digital imaging system. The imaging system consists of a thermoelectrically cooled CCD camera which views a Gadolinium based xray intensifying screen. The field of view of the imager is 30 x 30 cm which gives a 1.5 lp/mm spatial resolution at isocenter using a 1.5 xray magnification geometry. The user identifies the approximate position of the fiducial markers on the digital image using a mouse and a standard PC computer running an imaging software routine. The identified area is then analyzed to determine the projected position of the marker with sub-pixel (<0.5mm) accuracy. An algorithm based on rigid body transformations computes the three dimensional realignment motions necessary to bring the patient to the desired position for treatment. Results We have been using a system to reposition

Event boundaries and anaphoric reference.

Science.gov (United States)

Thompson, Alexis N; Radvansky, Gabriel A

2016-06-01

The current study explored the finding that parsing a narrative into separate events impairs anaphor resolution. According to the Event Horizon Model, when a narrative event boundary is encountered, a new event model is created. Information associated with the prior event model is removed from working memory. So long as the event model containing the anaphor referent is currently being processed, this information should still be available when there is no narrative event boundary, even if reading has been disrupted by a working-memory-clearing distractor task. In those cases, readers may reactivate their prior event model, and anaphor resolution would not be affected. Alternatively, comprehension may not be as event oriented as this account suggests. Instead, any disruption of the contents of working memory during comprehension, event related or not, may be sufficient to disrupt anaphor resolution. In this case, reading comprehension would be more strongly guided by other, more basic language processing mechanisms and the event structure of the described events would play a more minor role. In the current experiments, participants were given stories to read in which we included, between the anaphor and its referent, either the presence of a narrative event boundary (Experiment 1) or a narrative event boundary along with a working-memory-clearing distractor task (Experiment 2). The results showed that anaphor resolution was affected by narrative event boundaries but not by a working-memory-clearing distractor task. This is interpreted as being consistent with the Event Horizon Model of event cognition.

Fusion events

International Nuclear Information System (INIS)

Aboufirassi, M; Angelique, J.C.; Bizard, G.; Bougault, R.; Brou, R.; Buta, A.; Colin, J.; Cussol, D.; Durand, D.; Genoux-Lubain, A.; Horn, D.; Kerambrun, A.; Laville, J.L.; Le Brun, C.; Lecolley, J.F.; Lefebvres, F.; Lopez, O.; Louvel, M.; Meslin, C.; Metivier, V.; Nakagawa, T.; Peter, J.; Popescu, R.; Regimbart, R.; Steckmeyer, J.C.; Tamain, B.; Vient, E.; Wieloch, A.; Yuasa-Nakagawa, K.

1998-01-01

The fusion reactions between low energy heavy ions have a very high cross section. First measurements at energies around 30-40 MeV/nucleon indicated no residue of either complete or incomplete fusion, thus demonstrating the disappearance of this process. This is explained as being due to the high amount o energies transferred to the nucleus, what leads to its total dislocation in light fragments and particles. Exclusive analyses have permitted to mark clearly the presence of fusion processes in heavy systems at energies above 30-40 MeV/nucleon. Among the complete events of the Kr + Au reaction at 60 MeV/nucleon the majority correspond to binary collisions. Nevertheless, for the most considerable energy losses, a class of events do occur for which the detected fragments appears to be emitted from a unique source. These events correspond to an incomplete projectile-target fusion followed by a multifragmentation. Such events were singled out also in the reaction Xe + Sn at 50 MeV/nucleon. For the events in which the energy dissipation was maximal it was possible to isolate an isotropic group of events showing all the characteristics of fusion nuclei. The fusion is said to be incomplete as pre-equilibrium Z = 1 and Z = 2 particles are emitted. The cross section is of the order of 25 mb. Similar conclusions were drown for the systems 36 Ar + 27 Al and 64 Zn + nat Ti. A cross section value of ∼ 20 mb was determined at 55 MeV/nucleon in the first case, while the measurement of evaporation light residues in the last system gave an upper limit of 20-30 mb for the cross section at 50 MeV/nucleon

Evaluating Vegetation Type Effects on Land Surface Temperature at the City Scale

Science.gov (United States)

Wetherley, E. B.; McFadden, J. P.; Roberts, D. A.

2017-12-01

Understanding the effects of different plant functional types and urban materials on surface temperatures has significant consequences for climate modeling, water management, and human health in cities. To date, doing so at the urban scale has been complicated by small-scale surface heterogeneity and limited data. In this study we examined gradients of land surface temperature (LST) across sub-pixel mixtures of different vegetation types and urban materials across the entire Los Angeles, CA, metropolitan area (4,283 km2). We used AVIRIS airborne hyperspectral imagery (36 m resolution, 224 bands, 0.35 - 2.5 μm) to estimate sub-pixel fractions of impervious, pervious, tree, and turfgrass surfaces, validating them with simulated mixtures constructed from image spectra. We then used simultaneously imaged LST retrievals collected at multiple times of day to examine how temperature changed along gradients of the sub-pixel mixtures. Diurnal in situ LST measurements were used to confirm image values. Sub-pixel fractions were well correlated with simulated validation data for turfgrass (r2 = 0.71), tree (r2 = 0.77), impervious (r2 = 0.77), and pervious (r2 = 0.83) surfaces. The LST of pure pixels showed the effects of both the diurnal cycle and the surface type, with vegetated classes having a smaller diurnal temperature range of 11.6°C whereas non-vegetated classes had a diurnal range of 16.2°C (similar to in situ measurements collected simultaneously with the imagery). Observed LST across fractional gradients of turf/impervious and tree/impervious sub-pixel mixtures decreased linearly with increasing vegetation fraction. The slopes of decreasing LST were significantly different between tree and turf mixtures, with steeper slopes observed for turf (p < 0.05). These results suggest that different physiological characteristics and different access to irrigation water of urban trees and turfgrass results in significantly different LST effects, which can be detected at

Event-by-event fluctuations of mean transverse momentum in Au·Au ...

Indian Academy of Sciences (India)

Abstract. We report results on event-by-event fluctuations in mean transverse momentum in ... 0.150 < pt < 2.0 GeV/c are selected for the analysis. ... for gamma distribution are the mean event multiplicity, M , and the mean and variance of.

Safety significance of inadvertent operation of motor-operated valves in nuclear power plants

International Nuclear Information System (INIS)

Ruger, C.J.; Higgins, J.C.; Carbonaro, J.F.; Hall, R.E.

1994-01-01

Concerns about the consequences of valve mispositioning were brought to the forefront following an event at Davis Besse in 1985. The concern related to the ability to reposition open-quotes position-changeableclose quotes motor-operated valves (MOVs) from the control room in the event of their inadvertent operation and was documented in U.S. Nuclear Regulatory Commission (USNRC) Bulletin 85-03 and Generic Letter (GL) 89-10. The mispositioned MOVs may not be able to be returned to their required position due to high differential pressure or high flow conditions across the valves. The inability to reposition such valves may have significantly safety consequences, as in the Davis Besse event. However, full consideration of such mispositioning in safety analyses and in MOV test programs can be labor intensive and expensive. Industry raised concerns that consideration of position-changeable valves under GL 89-10 would not decrease the probability of core damage to an extent that would justify licensee costs. As a response, Brookhaven National Laboratory has conducted separate scoping studies for both boiling water reactors (BWRs) and pressurized water reactors (PWRs) using probabilistic risk assessment (PRA) techniques to determine if such valve mispositioning by itself is significant to safety. The approach used internal events PRA models to survey the order of magnitude of the risk-significance of valve mispositioning by considering the failure of selected position-changeable MOVs. The change in core damage frequency was determined for each valve considered, and the results were presented as a risk increase ratio for each of four assumed MOV failure rates. The risk increase ratios resulting from this failure rate sensitivity study can be used as a basis for a determination of the risk-significance of the MOV mispositioning issues for BWRs and PWRs

Use of the Hadoop structured storage tools for the ATLAS EventIndex event catalogue

CERN Document Server

Favareto, Andrea; The ATLAS collaboration; Cardenas Zarate, Simon Ernesto; Cranshaw, Jack; Fernandez Casani, Alvaro; Gallas, Elizabeth; Gonzalez de la Hoz, Santiago; Hrivnac, Julius; Malon, David; Prokoshin, Fedor; Salt, Jose; Sanchez, Javier; Toebbicke, Rainer; Yuan, Ruijun; Garcia Montoro, Carlos

2015-01-01

The ATLAS experiment collects billions of events per year of data-taking, and processes them to make them available for physics analysis in several different formats. An even larger amount of events is in addition simulated according to physics and detector models and then reconstructed and analysed to be compared to real events. The EventIndex is a catalogue of all events in each production stage; it includes for each event a few identification parameters, some basic non-mutable information coming from the online system, and the references to the files that contain the event in each format (plus the internal pointers to the event within each file for quick retrieval). Each EventIndex record is logically simple but the system has to hold many tens of billions of records, all equally important. The Hadoop technology was selected at the start of the EventIndex project development in 2012 and proved to be robust and flexible to accommodate this kind of information; both the insertion times and query response tim...

Event display of a H -> 2e2mu candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 2e2mu candidate event with m(4l) = 122.6 (123.9) GeV without (with) Z mass constraint. The masses of the lepton pairs are 87.9 GeV and 19.6 GeV. The event was recorded by ATLAS on 18-Jun-2012, 11:07:47 CEST in run number 205113 as event number 12611816. Muon tracks are colored red, electron tracks and clusters in the LAr calorimeter are colored green. The larger inset shows a zoom into the tracking detector. The smaller inset shows a zoom into the vertex region, indicating that the 4 leptons originate from the same primary vertex.

Treatment of external events in the linked event tree methodology NPP Goesgen - Daeniken example

International Nuclear Information System (INIS)

Kozlik, Thomas

2014-01-01

The NPP Goesgen-Daeniken uses a combined level 1 / level 2 PSA model for its event analyses. The model uses a linked event tree approach, using the software RISKMAN R . Each initiating event passes through a modularized event tree structure, consisting of external events pre-trees, alignment and support systems trees and front-line and containment response trees. This paper explains the structure of the linked event trees. Switches are used to bypass certain trees for specific initiating events. The screening process applied to possible external events is explained. The final scope of considered natural external events in the Goesgen PSA consists of earthquakes, seasonal events causing cooling water intake plugging or external floods. The structure of the natural external events pre-trees is explained. The treatment of external floods is explained in more detail. Floods at the Goesgen site are caused by extreme river flows into the old branch of the Aare river. A new model has been developed to analyse the probabilistic flood hazard using a bivariate distribution (water level and flood duration). Analysing the statistical data, the time trend had to be considered. The Goesgen PSA models 7 external flood initiating events, considering different water levels and durations at the flooded plant site. The building fragilities were developed in terms of resistance times. The RISKMAN R external flood pre-tree consists of top events for operator actions and failure of the building functions, which leads to the functional failure of equipment located at the lower elevation of the building. (author)

Comparison of online IGRT techniques for prostate IMRT treatment: Adaptive vs repositioning correction

International Nuclear Information System (INIS)

Thongphiew, Danthai; Wu, Q. Jackie; Lee, W. Robert; Chankong, Vira; Yoo, Sua; McMahon, Ryan; Yin Fangfang

2009-01-01

the rectum for 25, 16, and 19 fractions, respectively. For cases where the adapt plans did not score the best for OAR sparing, the gains of the OAR sparing in the repositioning-based plans were accompanied by an underdosage in the target volume. To further evaluate the fast online replanning technique, a gold-standard plan (''new'' plan) was generated for each CBCT anatomy on the Eclipse treatment planning system. The OAR sparing from the online replanning technique was compared to the new plan. The differences in D90, D50, and D30 of the OARs between the adapt and the new plans were less than 5% in 3 patients and were between 5% and 10% for the remaining three. In summary, all IGRT techniques could be sufficient to correct simple geometrical variations. However, when a high degree of deformation or differential organ position displacement occurs, the online reoptimization technique is feasible with less than 2 min optimization time and provides improvements in both CTV coverage and OAR sparing over the position correction techniques. For these cases, the reoptimization technique can be a highly valuable online IGRT tool to correct daily treatment uncertainties, especially when hypofractionation scheme is applied and daily correction, rather than averaging over many fractions, is required to match the original plan.

Event boundaries and memory improvement.

Science.gov (United States)

Pettijohn, Kyle A; Thompson, Alexis N; Tamplin, Andrea K; Krawietz, Sabine A; Radvansky, Gabriel A

2016-03-01

The structure of events can influence later memory for information that is embedded in them, with evidence indicating that event boundaries can both impair and enhance memory. The current study explored whether the presence of event boundaries during encoding can structure information to improve memory. In Experiment 1, memory for a list of words was tested in which event structure was manipulated by having participants walk through a doorway, or not, halfway through the word list. In Experiment 2, memory for lists of words was tested in which event structure was manipulated using computer windows. Finally, in Experiments 3 and 4, event structure was manipulated by having event shifts described in narrative texts. The consistent finding across all of these methods and materials was that memory was better when the information was distributed across two events rather than combined into a single event. Moreover, Experiment 4 demonstrated that increasing the number of event boundaries from one to two increased the memory benefit. These results are interpreted in the context of the Event Horizon Model of event cognition. Copyright © 2015 Elsevier B.V. All rights reserved.

Sudden Event Recognition: A Survey

Directory of Open Access Journals (Sweden)

Mohd Asyraf Zulkifley

2013-08-01

Full Text Available Event recognition is one of the most active research areas in video surveillance fields. Advancement in event recognition systems mainly aims to provide convenience, safety and an efficient lifestyle for humanity. A precise, accurate and robust approach is necessary to enable event recognition systems to respond to sudden changes in various uncontrolled environments, such as the case of an emergency, physical threat and a fire or bomb alert. The performance of sudden event recognition systems depends heavily on the accuracy of low level processing, like detection, recognition, tracking and machine learning algorithms. This survey aims to detect and characterize a sudden event, which is a subset of an abnormal event in several video surveillance applications. This paper discusses the following in detail: (1 the importance of a sudden event over a general anomalous event; (2 frameworks used in sudden event recognition; (3 the requirements and comparative studies of a sudden event recognition system and (4 various decision-making approaches for sudden event recognition. The advantages and drawbacks of using 3D images from multiple cameras for real-time application are also discussed. The paper concludes with suggestions for future research directions in sudden event recognition.

Repositioning Information Science.

OpenAIRE

Ibekwe-Sanjuan , Fidelia; Buckland , Michael; Latham , Kiersten

2010-01-01

International audience; During the twentieth century there was a strong desire for information studies to become scientific, to move from librarianship, bibliography, and documentation to an information science. In 1968 the American Documentation Institute was renamed American Society for Information Science. By the twenty-first century, however, departments of (library and) information science had turned instead towards the social sciences, but have not been successful in providing a coheren...

Underlying Event and B-Hadron Decays in $t\\overline{t}$ Events

CERN Document Server

INSPIRE-00175000

2014-01-01

We present exploratory studies of the underlying event activity and of fragmentation and hadronization of b quarks using $t\\overline{t}$ candidate events in proton-proton collision data acquired by the CMS experiment. We reconstruct charm mesons in fully charged decay channels from the reconstructed tracks associated with the hadronization of b quarks from the top decay, and study their kinematics relative to the mother jet. A good agreement is found using MadGraph plus the Pythia 6 Tune Z2* simulation. The effects predicted by alternative settings and generators for the characterization of the underlying event are also explored. These results are expected to contribute in the future to more precise measurements in the top quark sector in particular of the top quark mass by either constraining systematic uncertainties related to the modeling of the underlying event in $t\\overline{t}$ events or by paving the way for alternative mass measurement methods.

Event-by-event multiplicity fluctuations in Pb-Pb collisions in ALICE

CERN Document Server

Mukherjee, Maitreyee

2016-01-01

Fluctuations of various observables in heavy-ion collisions at ultra-relativistic energies have been extensively studied as they provide important signals regarding the formation of a Quark-Gluon Plasma (QGP). Because of the large number of produced particles in each event, a detailed study of event-by-event multiplicity fluctuations has been proposed as one of the signatures of the phase transition. In addition, the understanding of multiplicity fluctuations is essential for other event-by-event measurements. In the present work, we have calculated the scaled variance ($\\omega_{\\rm ch}=\\sigma^{\\rm 2} / \\mu$) of the charged-particle multiplicity distributions as a function of centrality in Pb-Pb collisions at LHC energies. Here, $\\mu$ and $\\sigma$ denote the mean and the width of the multiplicity distributions, respectively. The trend of scaled variances as a function of centrality is presented and discussed. Volume fluctuations play an important role while measuring the multiplicity fluctuations, which are a...

Trends and characteristics observed in nuclear events based on international nuclear event scale reports

International Nuclear Information System (INIS)

Watanabe, Norio

2001-01-01

The International Nuclear Event Scale (INES) is jointly operated by the IAEA and the OECD-NEA as a means designed for providing prompt, clear and consistent information related to nuclear events, that occurred at nuclear facilities, and facilitating communication between the nuclear community, the media and the public. Nuclear events are reported to the INES with the Scale', a consistent safety significance indicator, which runs from level 0, for events with no safety significance, to level 7 for a major accident with widespread health and environmental effects. Since the operation of INES was initiated in 1990, approximately 500 events have been reported and disseminated. The present paper discusses the trends observed in nuclear events, such as overall trends of the reported events and characteristics of safety significant events with level 2 or higher, based on the INES reports. (author)

Mathematical foundations of event trees

International Nuclear Information System (INIS)

Papazoglou, Ioannis A.

1998-01-01

A mathematical foundation from first principles of event trees is presented. The main objective of this formulation is to offer a formal basis for developing automated computer assisted construction techniques for event trees. The mathematical theory of event trees is based on the correspondence between the paths of the tree and the elements of the outcome space of a joint event. The concept of a basic cylinder set is introduced to describe joint event outcomes conditional on specific outcomes of basic events or unconditional on the outcome of basic events. The concept of outcome space partition is used to describe the minimum amount of information intended to be preserved by the event tree representation. These concepts form the basis for an algorithm for systematic search for and generation of the most compact (reduced) form of an event tree consistent with the minimum amount of information the tree should preserve. This mathematical foundation allows for the development of techniques for automated generation of event trees corresponding to joint events which are formally described through other types of graphical models. Such a technique has been developed for complex systems described by functional blocks and it is reported elsewhere. On the quantification issue of event trees, a formal definition of a probability space corresponding to the event tree outcomes is provided. Finally, a short discussion is offered on the relationship of the presented mathematical theory with the more general use of event trees in reliability analysis of dynamic systems

Event display of a H -> 2e2mu candidate event

CERN Multimedia

ATLAS, Collaboration

2012-01-01

Event display of a H -> 2e2mu candidate event with m(4l) = 122.6 (123.9) GeV without (with) Z mass constraint. The masses of the lepton pairs are 87.9 GeV and 19.6 GeV. The event was recorded by ATLAS on 18-Jun-2012, 11:07:47 CEST in run number 205113 as event number 12611816. Muon tracks are colored red, electron tracks and clusters in the LAr calorimeter are colored green. The Lego plot inset indicates the amount of transverse energy Et measured in the calorimeters. The second inset shows a zoom into the vertex region, indicating that the 4 leptons originate from the same primary vertex.

[Repair of fingertip amputations using composite grafts: nine clinical cases].

Science.gov (United States)

Al Saflan, A; May, P; Revol, M; Servant, J-M

2010-08-01

Even if a digital replantation is not possible, we present a series of nine cases of fingertip amputations treated with clinical efficacy by using a composite graft from the amputated finger part. All of our eight patients (four children and four adults) were traumatically amputated. The level of amputation passed by the bunch of P3 and carried partially or completely the ungula. The reposition was always performed under local anaesthesia. Our evaluation related on the survival of the composite grafts, the functional and the aesthetic result. The composite grafts were revascularised in eight amputations out of nine, with a satisfactory remote result on the function as well as aesthetic level. After a short recall of the alternative surgical methods of the treatment of the fingertip amputations, we will insist on the simplicity and the reliability of the repositioning of a composite graft, recommended for us from the start and depending on the traumatic level. In the event of a failure, surgeons still have the possibility of realising the other alternative surgical methods. 2009. Published by Elsevier SAS.

Advertising Effectiveness In Events

OpenAIRE

Jain, Sushilkumar

2012-01-01

Confronted with decreasing effectiveness of the classic marketing communications, events have become an increasingly popular alternative for marketers. Events constitute one of the most exciting and fastest growing forms of leisure and business. With time, the decreasing effectiveness of classical marketing communications boosted the use of events for marketing and making brand awareness. Event marketing is seen as the unique opportunity to integrate the firm’s communication activities like p...

Features, Events, and Processes: Disruptive Events

Energy Technology Data Exchange (ETDEWEB)

J. King

2004-03-31

The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report.

Features, Events, and Processes: Disruptive Events

International Nuclear Information System (INIS)

J. King

2004-01-01

The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report

Fast algorithm for spectral processing with application to on-line welding quality assurance

Science.gov (United States)

Mirapeix, J.; Cobo, A.; Jaúregui, C.; López-Higuera, J. M.

2006-10-01

A new technique is presented in this paper for the analysis of welding process emission spectra to accurately estimate in real-time the plasma electronic temperature. The estimation of the electronic temperature of the plasma, through the analysis of the emission lines from multiple atomic species, may be used to monitor possible perturbations during the welding process. Unlike traditional techniques, which usually involve peak fitting to Voigt functions using the Levenberg-Marquardt recursive method, sub-pixel algorithms are used to more accurately estimate the central wavelength of the peaks. Three different sub-pixel algorithms will be analysed and compared, and it will be shown that the LPO (linear phase operator) sub-pixel algorithm is a better solution within the proposed system. Experimental tests during TIG-welding using a fibre optic to capture the arc light, together with a low cost CCD-based spectrometer, show that some typical defects associated with perturbations in the electron temperature can be easily detected and identified with this technique. A typical processing time for multiple peak analysis is less than 20 ms running on a conventional PC.

Soundscapes, events, resistance

Directory of Open Access Journals (Sweden)

Andrea Mubi Brighenti

2008-12-01

Full Text Available Put it bluntly, a soundscape is the sonic counterpart, or component, of landscape. From such minimal assumption, some interesting consequences follow: just as landscape is far from being a simple stage-set upon which events take place, soundscape, too, is itself evental, i.e., it consists of events. Not only because its nature, far from being acoustics is always ‘psychoacoustics’, as Murray Schafer (1977/1994 first argued. Processes of environmental perception are of course there.

Conferences and Events

International Development Research Centre (IDRC) Digital Library (Canada)

André Lavoie

2016-06-14

Jun 14, 2016 ... Approved by the Management Executive Committee. - 1 - ... Event ‒ represents activities related to IDRC operations and may include both ... Events include business meetings; corporate, branch or divisional management.

Human Performance Event Database

International Nuclear Information System (INIS)

Trager, E. A.

1998-01-01

The purpose of this paper is to describe several aspects of a Human Performance Event Database (HPED) that is being developed by the Nuclear Regulatory Commission. These include the background, the database structure and basis for the structure, the process for coding and entering event records, the results of preliminary analyses of information in the database, and plans for the future. In 1992, the Office for Analysis and Evaluation of Operational Data (AEOD) within the NRC decided to develop a database for information on human performance during operating events. The database was needed to help classify and categorize the information to help feedback operating experience information to licensees and others. An NRC interoffice working group prepared a list of human performance information that should be reported for events and the list was based on the Human Performance Investigation Process (HPIP) that had been developed by the NRC as an aid in investigating events. The structure of the HPED was based on that list. The HPED currently includes data on events described in augmented inspection team (AIT) and incident investigation team (IIT) reports from 1990 through 1996, AEOD human performance studies from 1990 through 1993, recent NRR special team inspections, and licensee event reports (LERs) that were prepared for the events. (author)

Serious adverse events with infliximab: analysis of spontaneously reported adverse events.

Science.gov (United States)

Hansen, Richard A; Gartlehner, Gerald; Powell, Gregory E; Sandler, Robert S

2007-06-01

Serious adverse events such as bowel obstruction, heart failure, infection, lymphoma, and neuropathy have been reported with infliximab. The aims of this study were to explore adverse event signals with infliximab by using a long period of post-marketing experience, stratifying by indication. The relative reporting of infliximab adverse events to the U.S. Food and Drug Administration (FDA) was assessed with the public release version of the adverse event reporting system (AERS) database from 1968 to third quarter 2005. On the basis of a systematic review of adverse events, Medical Dictionary for Regulatory Activities (MedDRA) terms were mapped to predefined categories of adverse events, including death, heart failure, hepatitis, infection, infusion reaction, lymphoma, myelosuppression, neuropathy, and obstruction. Disproportionality analysis was used to calculate the empiric Bayes geometric mean (EBGM) and corresponding 90% confidence intervals (EB05, EB95) for adverse event categories. Infliximab was identified as the suspect medication in 18,220 reports in the FDA AERS database. We identified a signal for lymphoma (EB05 = 6.9), neuropathy (EB05 = 3.8), infection (EB05 = 2.9), and bowel obstruction (EB05 = 2.8). The signal for granulomatous infections was stronger than the signal for non-granulomatous infections (EB05 = 12.6 and 2.4, respectively). The signals for bowel obstruction and infusion reaction were specific to patients with IBD; this suggests potential confounding by indication, especially for bowel obstruction. In light of this additional evidence of risk of lymphoma, neuropathy, and granulomatous infections, clinicians should stress this risk in the shared decision-making process.

Development of re-locatable head frame system using hydraulic arms for fractionated stereotactic radiotherapy and CT evaluation of repositioning accuracy

International Nuclear Information System (INIS)

Kitamura, Masayuki; Kunieda, Etsuo; Kawaguchi, Osamu; Ando, Yutaka; Shigematsu, Naoyuki; Shiba, Toshiyuki; Kubo, Atsushi

2002-01-01

The purpose of this study was to develop a novel re-locatable head frame system consisting of a dental cast and hydraulic arms as an immobilization device for fractionated stereotactic radiotherapy and to evaluate the repositioning accuracy by measurement of landmark coordinates in repeated computed tomography (CT) examinations. The acrylic dental casts were customized for each patient. First the dental cast was attached to the upper jaw of the patient, then the dental cast was connected to a Leksell stereotactic frame, which was finally secured by two hydraulic arms. Since this system is compatible with the Leksell frame, stereotactic indicators could be used to obtain coordinates of anatomical landmarks of the head. Seven patients treated by fractionated stereotactic radiotherapy underwent repeated quality-assurance CTs during their treatment courses. We evaluated the coordinates of the short process of incus and the top of crista galli as reference points for evaluation of variation in a total of 26 repeat CT data sets, and then x, y, and z fluctuations relative to their positions in the treatment-planning CTs. The distances among the reference points of both processes of incus and the top of crista galli were calculated to evaluate the feasibility of the method. The distances were less than 0.5 mm on averages and less than 1 mm in the standard deviations. The respective fluctuations in the x, y and z directions were less than 1 mm in mean values and less than 2 mm in standard deviations. The fluctuations in distance were less than 2 mm on average and in standard deviations. The fluctuation of the center of three reference points was 0.7 mm on average and the rotation of the cranium was 1.0 degree in average. We concluded that our evaluation method is feasible and the reproducibility of the fixation system is acceptable for its routine use in stereotactic radiotherapy. (author)

A Monte Carlo study on event-by-event transverse momentum fluctuation at RHIC

International Nuclear Information System (INIS)

Xu Mingmei

2005-01-01

The experimental observation on the multiplicity dependence of event-by-event transverse momentum fluctuation in relativistic heavy ion collisions is studied using Monte Carlo simulation. It is found that the Monte Carlo generator HIJING is unable to describe the experimental phenomenon well. A simple Monte Carlo model is proposed, which can recover the data and thus shed some light on the dynamical origin of the multiplicity dependence of event-by-event transverse momentum fluctuation. (authors)

Seeing Iconic Gestures While Encoding Events Facilitates Children's Memory of These Events.

Science.gov (United States)

Aussems, Suzanne; Kita, Sotaro

2017-11-08

An experiment with 72 three-year-olds investigated whether encoding events while seeing iconic gestures boosts children's memory representation of these events. The events, shown in videos of actors moving in an unusual manner, were presented with either iconic gestures depicting how the actors performed these actions, interactive gestures, or no gesture. In a recognition memory task, children in the iconic gesture condition remembered actors and actions better than children in the control conditions. Iconic gestures were categorized based on how much of the actors was represented by the hands (feet, legs, or body). Only iconic hand-as-body gestures boosted actor memory. Thus, seeing iconic gestures while encoding events facilitates children's memory of those aspects of events that are schematically highlighted by gesture. © 2017 The Authors. Child Development © 2017 Society for Research in Child Development, Inc.

Assessing the association between omalizumab and arteriothrombotic events through spontaneous adverse event reporting

Directory of Open Access Journals (Sweden)

Ali AK

2012-05-01

Full Text Available Ayad K Ali, Abraham G HartzemaDepartment of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USABackground: Omalizumab is a monoclonal antibody, indicated for the treatment of severe allergic asthma. In Europe, there have been concerns about the cardiovascular safety of omalizumab. The objective of this study was to analyze the association between omalizumab and arterial thrombotic events in a spontaneous adverse drug reaction reporting database in the US.Methods and materials: Reports of arterial thrombotic events submitted to the US Food and Drug Administration's Adverse Event Reporting System (AERS between 2004 and 2011 were retrieved and analyzed by the reporting odds ratio data mining algorithm. The reporting odds ratio of arterial thrombotic events for omalizumab was compared with specific asthma medications and all drugs in the AERS. Values ≥2 were considered significant safety signals. The Medical Dictionary for Regulatory Activities Preferred Terms were used to identify arterial thrombotic events (eg, stroke, myocardial infarction.Results: In total, 293,783 reports of arterial thrombotic events were retrieved (about 2% of all adverse drug reaction reports, corresponding to 2274 asthma drug-arterial thrombotic events pairs (omalizumab, 222; inhaled corticosteroids [ICS], 131; long-acting beta-agonists [LABA], 102; single-device combination ICS-LABA, 506; inhaled short-acting beta-agonists [SABA], 475; oral SABA, 6; inhaled antimuscarinics [AMC], 477; single-device combination AMC-SABA, 127; xanthines, 50; leukotriene modifiers, 174; and mast cell stabilizers, 4. Reporting odds ratio and 95% confidence interval values for omalizumab compared with other asthma drugs and all drugs in AERS were 2.75 (2.39–316 and 1.09 (0.95–1.24, respectively. Omalizumab ranked second after ICS in the risk of arterial thrombotic events, followed by AMC, AMC-SABA, and ICS-LABA.Conclusion: Omalizumab is

Event shape sorting

International Nuclear Information System (INIS)

Kopecna, Renata; Tomasik, Boris

2016-01-01

We propose a novel method for sorting events of multiparticle production according to the azimuthal anisotropy of their momentum distribution. Although the method is quite general, we advocate its use in analysis of ultra-relativistic heavy-ion collisions where a large number of hadrons is produced. The advantage of our method is that it can automatically sort out samples of events with histograms that indicate similar distributions of hadrons. It takes into account the whole measured histograms with all orders of anisotropy instead of a specific observable (e.g., v 2 , v 3 , q 2 ). It can be used for more exclusive experimental studies of flow anisotropies which are then more easily compared to theoretical calculations. It may also be useful in the construction of mixed-events background for correlation studies as it allows to select events with similar momentum distribution. (orig.)

Life events and Tourette syndrome.

Science.gov (United States)

Steinberg, Tamar; Shmuel-Baruch, Sharona; Horesh, Netta; Apter, Alan

2013-07-01

Tourette syndrome (TS) is a neuropsychiatric developmental disorder characterized by the presence of multiple motor tics and one or more vocal tics. Although TS is primarily biological in origin, stress-diatheses interactions most probably play a role in the course of the illness. The precise influence of the environment on this basically biological disorder is difficult to ascertain, particularly when TS is complicated by comorbidities. Among the many questions that remain unresolved are the differential impact of positive and negative events and specific subtypes of events, and the importance of major crucial events relative to minor daily ones to tic severity. To examine the relationships between life events, tic severity and comorbid disorders in Tourette Syndrome (TS), including OCD, ADHD, anxiety, depression and rage attacks. Life events were classified by quantity, quality (positive or negative) and classification types of events (family, friends etc.). Sixty patients aged 7-17 years with Tourette syndrome or a chronic tic disorder were recruited from Psychological Medicine Clinic in Schneider Children's Medical Center of Israel. Yale Global Tic Severity Scale; Children's Yale Brown Obsessive Compulsive Scale; Life Experiences Survey; Brief Adolescent Life Events Scale; Screen for Child Anxiety Related Emotional Disorders; Child Depression Inventory/Beck Depression Inventory; ADHD Rating Scale IV; Overt Aggression Scale. Regarding tics and minor life events, there was a weak but significant correlation between severity of motor tics and the quantity of negative events. No significant correlation was found between tic severity and quantity of positive events. Analysis of the BALES categories yielded a significant direct correlation between severity of vocal tics and quantity of negative events involving friends. Regarding comorbidities and minor life events, highly significant correlations were found with depression and anxiety. Regarding tics and major life

Event-by-event jet quenching and higher Fourier moments of hard probes

Energy Technology Data Exchange (ETDEWEB)

Fries, Rainer J. [Cyclotron Institute and Department of Physics and Astronomy, Texas A and M University, College Station TX 77845 (United States); RIKEN/BNL Research Center, Brookhaven National Laboratory, Upton NY 11973 (United States); Rodriguez, Ricardo [Department of Mathematics and Physics, Ave Maria University, Ave Maria FL 34142 (United States); Cyclotron Institute, Texas A and M University, College Station TX 77845 (United States)

2011-04-01

We investigate the effect of event-by-event fluctuations of the fireball created in high energy nuclear collisions on hard probe observables. We show that spatial inhomogeneities lead to changes in the nuclear suppression factor of high momentum hadrons which can be absorbed in the quenching strength q-hat. This can increase the theoretical uncertainty on extracted values of q-hat by up to 50%. We also investigate effects on azimuthal asymmetries v{sub 2} and dihadron correlation functions. The latter show a promising residual signal of event-by-event quenching that might allow us to estimate the size of spatial inhomogeneities in the fireball from experimental data.

Measurements of the event shapes and underlying event in pp collisions at 7 TeV

CERN Document Server

Astalos, R; The ATLAS collaboration

2013-01-01

The high-energy pp collisions at the LHC provide unique opportunity to study particle flow and event shapes of the hadronic final state particles. Evolution of the event shape variables, such as the transverse thrust, thrust minor and transverse sphericity have been studied for minimum bias events. Particle distributions sensitive to the underlying event have been measured using calorimeter jet events. Separate inclusive jet and exclusive dijet event selections are included in this study for various observables. The data are compared with predictions from several MC simulations.

Event-by-Event Elliptic Flow Fluctuations from PHOBOS

Science.gov (United States)

Wosiek, B.; Alver, B.; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Busza, W.; Carroll, A.; Chai, Z.; Chetluru, V.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Halliwell, C.; Hamblen, J.; Harnarine, I.; Hauer, M.; Henderson, C.; Hofman, D. J.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kulinich, P.; Kuo, C. M.; Li, W.; Lin, W. T.; Loizides, C.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Reed, C.; Richardson, E.; Roland, C.; Roland, G.; Sagerer, J.; Seals, H.; Sedykh, I.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Szostak, A.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Walters, P.; Wenger, E.; Willhelm, D.; Wolfs, F. L. H.; Woźniak, K.; Wyngaardt, S.; Wysłouch, B.

2009-04-01

Recently PHOBOS has focused on the study of fluctuations and correlations in particle production in heavy-ion collisions at the highest energies delivered by the Relativistic Heavy Ion Collider (RHIC). In this report, we present results on event-by-event elliptic flow fluctuations in (Au+Au) collisions at sqrt {sNN}=200 GeV. A data-driven method was used to estimate the dominant contribution from non-flow correlations. Over the broad range of collision centralities, the observed large elliptic flow fluctuations are in agreement with the fluctuations in the initial source eccentricity.

Centrality of event across cultures. Emotionally positive and negative events in Mexico, China, Greenland, and Denmark

DEFF Research Database (Denmark)

Zaragoza Scherman, Alejandra; Salgado, Sinué; Shao, Zhifang

During their lifetime, people experience both emotionally positive and negative events. The Centrality of Event Scale (CES; Berntsen and Rubin, 2006; Berntsen, Rubin and Siegler, 2011) measures the extent to which an event is central to someone’s identity and life story. An event becomes central...... disorder (PTSD) and depression symptoms: Participants with higher PTSD and depression scores reported that a traumatic or negative event was highly central to their identity and life story; and 3) A significant number of positive event occurred during participants’ adolescence and early adulthood, while...... an emotional event into our life story and our identity. Key findings: 1) Positive events are rated as more central to identity than negative events; 2) The extent to which highly traumatic and negative events become central to a person’s life story and identity varies as a function of post-traumatic stress...

Dynamic SEP event probability forecasts

Science.gov (United States)

Kahler, S. W.; Ling, A.

2015-10-01

The forecasting of solar energetic particle (SEP) event probabilities at Earth has been based primarily on the estimates of magnetic free energy in active regions and on the observations of peak fluxes and fluences of large (≥ M2) solar X-ray flares. These forecasts are typically issued for the next 24 h or with no definite expiration time, which can be deficient for time-critical operations when no SEP event appears following a large X-ray flare. It is therefore important to decrease the event probability forecast with time as a SEP event fails to appear. We use the NOAA listing of major (≥10 pfu) SEP events from 1976 to 2014 to plot the delay times from X-ray peaks to SEP threshold onsets as a function of solar source longitude. An algorithm is derived to decrease the SEP event probabilities with time when no event is observed to reach the 10 pfu threshold. In addition, we use known SEP event size distributions to modify probability forecasts when SEP intensity increases occur below the 10 pfu event threshold. An algorithm to provide a dynamic SEP event forecast, Pd, for both situations of SEP intensities following a large flare is derived.

ECONOMIC, SOCIAL AND POLITICAL FACTS AND PERSPECTIVES OF 2017

Directory of Open Access Journals (Sweden)

Liviu RADU

2017-05-01

Full Text Available Following the turbulent year of 2016, with deep geopolitical changes, the new year of 2017 promises to be full of challenges in what concerns the economic, social, political and geostrategic area. The key events of the last year (the Brexit, the elections in the USA, the events in Turkey, the force demonstrations of Russia, the situation of the migration wave etc. shall have an impact on the global economic development and on the repositioning of its main actors. This paperwork intends to analyze the main consequences of the recent events on the short term progress in what concerns the economic, social, political and geostrategic area. We hereby intend to review the facts and the main potential progress on the economic status of this year which was so complicated, both for the European Union and for every member of it.

A review for identification of initiating events in event tree development process on nuclear power plants

International Nuclear Information System (INIS)

Riyadi, Eko H.

2014-01-01

Initiating event is defined as any event either internal or external to the nuclear power plants (NPPs) that perturbs the steady state operation of the plant, if operating, thereby initiating an abnormal event such as transient or loss of coolant accident (LOCA) within the NPPs. These initiating events trigger sequences of events that challenge plant control and safety systems whose failure could potentially lead to core damage or large early release. Selection for initiating events consists of two steps i.e. first step, definition of possible events, such as by evaluating a comprehensive engineering, and by constructing a top level logic model. Then the second step, grouping of identified initiating event's by the safety function to be performed or combinations of systems responses. Therefore, the purpose of this paper is to discuss initiating events identification in event tree development process and to reviews other probabilistic safety assessments (PSA). The identification of initiating events also involves the past operating experience, review of other PSA, failure mode and effect analysis (FMEA), feedback from system modeling, and master logic diagram (special type of fault tree). By using the method of study for the condition of the traditional US PSA categorization in detail, could be obtained the important initiating events that are categorized into LOCA, transients and external events

Multiplexing real-time timed events

NARCIS (Netherlands)

Holenderski, M.J.; Cools, W.A.; Bril, R.J.; Lukkien, J.J.

2009-01-01

This paper presents the design and implementation of RELTEQ, a timed event management algorithm based on relative event times, supporting long event interarrival time, long lifetime of the event queue, no drift and low overhead. It is targeted at embedded operating systems. RELTEQ has been conceived

Recent results on event-by-event fluctuations in ALICE at the LHC

CERN Document Server

AUTHOR|(CDS)2083375

2015-01-01

Non-statistical event-by-event fluctuations in relativistic heavy-ion collisions have been proposed as a probe of the phase transition of hadronic matter to a deconfined phase of quarks and gluons, the so-called Quark-Gluon Plasma. In a thermodynamical picture of the strongly interacting system formed in heavy-ion collisions, the dynamical fluctuations of net-charge, fluctuations of the mean transverse momentum, mean multiplicity and balance functions are related to the fundamental properties of the system, hence they may reveal information about the QCD phase transition. In this article, recent results on event-by-event measurements of net-charge fluctuations, the measurement of the balance function and mean transverse momentum fluctuations are discussed.

The Advanced Photon Source event system

International Nuclear Information System (INIS)

Lenkszus, F.R.; Laird, R.

1995-01-01

The Advanced Photon Source, like many other facilities, requires a means of transmitting timing information to distributed control system 1/0 controllers. The APS event system provides the means of distributing medium resolution/accuracy timing events throughout the facility. It consists of VME event generators and event receivers which are interconnected with 10OMbit/sec fiber optic links at distances of up to 650m in either a star or a daisy chain configuration. The systems event throughput rate is 1OMevents/sec with a peak-to-peak timing jitter down to lOOns depending on the source of the event. It is integrated into the EPICS-based A.PS control system through record and device support. Event generators broadcast timing events over fiber optic links to event receivers which are programmed to decode specific events. Event generators generate events in response to external inputs, from internal programmable event sequence RAMS, and from VME bus writes. The event receivers can be programmed to generate both pulse and set/reset level outputs to synchronize hardware, and to generate interrupts to initiate EPICS record processing. In addition, each event receiver contains a time stamp counter which is used to provide synchronized time stamps to EPICS records

A review for identification of initiating events in event tree development process on nuclear power plants

Energy Technology Data Exchange (ETDEWEB)

Riyadi, Eko H., E-mail: e.riyadi@bapeten.go.id [Center for Regulatory Assessment of Nuclear Installation and Materials, Nuclear Energy Regulatory Agency (BAPETEN), Jl. Gajah Mada 8 Jakarta 10120 (Indonesia)

2014-09-30

Initiating event is defined as any event either internal or external to the nuclear power plants (NPPs) that perturbs the steady state operation of the plant, if operating, thereby initiating an abnormal event such as transient or loss of coolant accident (LOCA) within the NPPs. These initiating events trigger sequences of events that challenge plant control and safety systems whose failure could potentially lead to core damage or large early release. Selection for initiating events consists of two steps i.e. first step, definition of possible events, such as by evaluating a comprehensive engineering, and by constructing a top level logic model. Then the second step, grouping of identified initiating event's by the safety function to be performed or combinations of systems responses. Therefore, the purpose of this paper is to discuss initiating events identification in event tree development process and to reviews other probabilistic safety assessments (PSA). The identification of initiating events also involves the past operating experience, review of other PSA, failure mode and effect analysis (FMEA), feedback from system modeling, and master logic diagram (special type of fault tree). By using the method of study for the condition of the traditional US PSA categorization in detail, could be obtained the important initiating events that are categorized into LOCA, transients and external events.

The Blayais event

International Nuclear Information System (INIS)

2000-01-01

This document provides the main events occurred to the Blayais installation during the year 2000. For each events, the detailed chronology, the situation analysis, the crisis management and the public information are provided. Some recommendations are also provided by the nuclear safety authorities. (A.L.B.)

Comparison of the 26 May 2012 SEP Event with the 3 November 2011 SEP Event

Science.gov (United States)

Makela, P. A.; Gopalswamy, N.; Thakur, N.; Xie, H.

2015-12-01

We compare the solar and interplanetary events associated with two large solar energetic particle (SEP) events on 26 May 2012 and 3 November 2011. Both SEP events were detected at three longitudinally widely separated locations by STEREO A and B spacecraft (more than 100 deg away from Earth) and the Wind and SOHO spacecraft near Earth. In Earth view, the November 2011 eruption occurred far behind the east limb at N09E154, whereas the May 2012 eruption occurred closer to the west limb at N15W121, suggesting that SEPs accelerated during the 2012 event might have easier access to Earth. Even though the 2012 event was more intense in the GOES >10 MeV proton channel (peak intensity 14 pfu) than the 2011 event (peak intensity 4 pfu), we find that the latter event was more intense at higher energies (> 40 MeV). Also, the initial rise at lower energies was slightly faster for the 2011 event as measured by SOHO/ERNE. In addition, the CME associated with the May 2012 event was faster with an estimated space speed of ~2029 km/s than that in the November 2011 event (1188 km/s). STEREO/EUVI images of the associated post-eruption arcades (PEAs) indicate that their orientations were different: the PEA of the May 2012 event had a high inclination (north-south), while the inclination of the PEA of the 2011 event was more moderate. Differences in the flux rope orientation may also have effect on the longitudinal extent of the SEP events. These observations suggest that the dependence of solar proton intensities on the observer's longitudinal distance from the solar source is more complex than traditionally assumed.

Seeing iconic gestures while encoding events facilitates children's memory of these events

OpenAIRE

Aussems, Suzanne; Kita, Sotaro

2017-01-01

An experiment with 72 three-year-olds investigated whether encoding events while seeing iconic gestures boosts children's memory representation of these events. The events, shown in videos of actors moving in an unusual manner, were presented with either iconic gestures depicting how the actors performed these actions, interactive gestures, or no gesture. In a recognition memory task, children in the iconic gesture condition remembered actors and actions better than children in the control co...

Assessing the association between omalizumab and arteriothrombotic events through spontaneous adverse event reporting.

Science.gov (United States)

Ali, Ayad K; Hartzema, Abraham G

2012-01-01

Omalizumab is a monoclonal antibody, indicated for the treatment of severe allergic asthma. In Europe, there have been concerns about the cardiovascular safety of omalizumab. The objective of this study was to analyze the association between omalizumab and arterial thrombotic events in a spontaneous adverse drug reaction reporting database in the US. Reports of arterial thrombotic events submitted to the US Food and Drug Administration's Adverse Event Reporting System (AERS) between 2004 and 2011 were retrieved and analyzed by the reporting odds ratio data mining algorithm. The reporting odds ratio of arterial thrombotic events for omalizumab was compared with specific asthma medications and all drugs in the AERS. Values ≥2 were considered significant safety signals. The Medical Dictionary for Regulatory Activities Preferred Terms were used to identify arterial thrombotic events (eg, stroke, myocardial infarction). In total, 293,783 reports of arterial thrombotic events were retrieved (about 2% of all adverse drug reaction reports), corresponding to 2274 asthma drug-arterial thrombotic events pairs (omalizumab, 222; inhaled corticosteroids [ICS], 131; long-acting beta-agonists [LABA], 102; single-device combination ICS-LABA, 506; inhaled short-acting beta-agonists [SABA], 475; oral SABA, 6; inhaled antimuscarinics [AMC], 477; single-device combination AMC-SABA, 127; xanthines, 50; leukotriene modifiers, 174; and mast cell stabilizers, 4). Reporting odds ratio and 95% confidence interval values for omalizumab compared with other asthma drugs and all drugs in AERS were 2.75 (2.39-316) and 1.09 (0.95-1.24), respectively. Omalizumab ranked second after ICS in the risk of arterial thrombotic events, followed by AMC, AMC-SABA, and ICS-LABA. Omalizumab is associated with higher than expected reporting of arterial thrombotic events in asthmatic patients. This hypothesis needs further testing in robust epidemiological studies.

ANALYSIS OF EVENT TOURISM IN RUSSIA, ITS FUNCTIONS, WAYS TO IMPROVE THE EFFICIENCY OF EVENT

Directory of Open Access Journals (Sweden)

Mikhail Yur'evich Grushin

2016-01-01

Full Text Available This article considers one of the important directions of development of the national economy in the area of tourist services – development of event tourism in the Russian Federation. Today the market of event management in Russia is in the process of formation, therefore its impact on the socio-economic development of regions and Russia as a whole is minimal, and the analysis of the influence is not performed. This problem comes to the fore in the regions of Russia, specializing in the creation of event-direction tourist-recreational cluster. The article provides an analysis of the existing market of event management and event tourism functions. Providing the ways to improve the efficiency of event management and recommendations for the organizer of events in the regions. The article shows the specific role of event tourism in the national tourism and provides direction for the development of organizational and methodical recommendations on its formation in the regions of Russia and the creation of an effective management system at the regional level. The purpose of this article is to analyze the emerging in Russia event tourism market and its specifics. On the basis of these studies are considered folding patterns of the new market and the assessment of its impact on the modern national tourism industry. Methodology. To complete this article are used comparative and economic and statistical analysis methods. Conclusions/significance. The practical importance of this article is in the elimination of existing in the national tourism industry contradictions: on the one hand, in the Russian Federation is annually held a large amount events activities, including world-class in all regions say about tourist trips to the event, but the event tourism does not exist yet. In all regions, there is an internal and inbound tourism, but it has nothing to do with the event tourism. The article has a practical conclusions demonstrate the need to adapt the

Sequencing of bimaxillary surgery in the correction of vertical maxillary excess: retrospective study.

Science.gov (United States)

Salmen, F S; de Oliveira, T F M; Gabrielli, M A C; Pereira Filho, V A; Real Gabrielli, M F

2018-06-01

The aim of this study was to evaluate the precision of bimaxillary surgery performed to correct vertical maxillary excess, when the procedure is sequenced with mandibular surgery first or maxillary surgery first. Thirty-two patients, divided into two groups, were included in this retrospective study. Group 1 comprised patients who received bimaxillary surgery following the classical sequence with repositioning of the maxilla first. Patients in group 2 received bimaxillary surgery, but the mandible was operated on first. The precision of the maxillomandibular repositioning was determined by comparison of the digital prediction and postoperative tracings superimposed on the cranial base. The data were tabulated and analyzed statistically. In this sample, both surgical sequences provided adequate clinical accuracy. The classical sequence, repositioning the maxilla first, resulted in greater accuracy for A-point and the upper incisor edge vertical position. Repositioning the mandible first allowed greater precision in the vertical position of pogonion. In conclusion, although both surgical sequences may be used, repositioning the mandible first will result in greater imprecision in relation to the predictive tracing than repositioning the maxilla first. The classical sequence resulted in greater accuracy in the vertical position of the maxilla, which is key for aesthetics. Copyright © 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

DEVS representation of dynamical systems - Event-based intelligent control. [Discrete Event System Specification

Science.gov (United States)

Zeigler, Bernard P.

1989-01-01

It is shown how systems can be advantageously represented as discrete-event models by using DEVS (discrete-event system specification), a set-theoretic formalism. Such DEVS models provide a basis for the design of event-based logic control. In this control paradigm, the controller expects to receive confirming sensor responses to its control commands within definite time windows determined by its DEVS model of the system under control. The event-based contral paradigm is applied in advanced robotic and intelligent automation, showing how classical process control can be readily interfaced with rule-based symbolic reasoning systems.

Transportation planning for planned special events

Science.gov (United States)

2011-05-01

Unique among planned special event activities are those events that carry the National Special Security Event (NSSE) designation. NSSEs occur with some frequency, with 35 of these events held between September 1998 and February 2010. These events inc...

The ISC Seismic Event Bibliography

Science.gov (United States)

Di Giacomo, Domenico; Storchak, Dmitry

2015-04-01

The International Seismological Centre (ISC) is a not-for-profit organization operating in the UK for the last 50 years and producing the ISC Bulletin - the definitive worldwide summary of seismic events, both natural and anthropogenic - starting from the beginning of 20th century. Often researchers need to gather information related to specific seismic events for various reasons. To facilitate such task, in 2012 we set up a new database linking earthquakes and other seismic events in the ISC Bulletin to bibliographic records of scientific articles (mostly peer-reviewed journals) that describe those events. Such association allows users of the ISC Event Bibliography (www.isc.ac.uk/event_bibliography/index.php) to run searches for publications via a map-based web interface and, optionally, selecting scientific publications related to either specific events or events in the area of interest. Some of the greatest earthquakes were described in several hundreds of articles published over a period of few years. The journals included in our database are not limited to seismology but bring together a variety of fields in geosciences (e.g., engineering seismology, geodesy and remote sensing, tectonophysics, monitoring research, tsunami, geology, geochemistry, hydrogeology, atmospheric sciences, etc.) making this service useful in multidisciplinary studies. Usually papers dealing with large data set are not included (e.g., papers describing a seismic catalogue). Currently the ISC Event Bibliography includes over 17,000 individual publications from about 500 titles related to over 14,000 events that occurred in last 100+ years. The bibliographic records in the Event Bibliography start in the 1950s, and it is updated as new publications become available.

Business Event Notification Service (BENS)

Data.gov (United States)

Department of Veterans Affairs — BENS provides a notification of pre-defined business events to applications, portals, and automated business processes. Such events are defined in the Event Catalog,...

Safeguards summary event list (SSEL)

International Nuclear Information System (INIS)

1989-07-01

The Safeguards Summary Event List (SSEL) provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC). Because of public interest, also included are events reported involving byproduct material which is exempt from safeguards requirements. Events are described under the categories of bomb-related, intrusion, missing and/or allegedly stolen, transportation, tampering/vandalism, arson, firearms, radiological sabotage, nonradiological sabotage, alcohol and drugs, and miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

Safeguards Summary Event List (SSEL)

International Nuclear Information System (INIS)

Fadden, M.; Yardumian, J.

1993-07-01

The Safeguards Summary Event List provides brief summaries of hundreds of safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission. Events are described under the categories: Bomb-related, Intrusion, Missing/Allegedly Stolen, Transportation-related, Tampering/Vandalism, Arson, Firearms-related, Radiological Sabotage, Non-radiological Sabotage, and Miscellaneous. Because of the public interest, the Miscellaneous category also includes events reported involving source material, byproduct material, and natural uranium, which are exempt from safeguards requirements. Information in the event descriptions was obtained from official NRC sources

Piecing together the puzzle: Improving event content coverage for real-time sub-event detection using adaptive microblog crawling.

Science.gov (United States)

Tokarchuk, Laurissa; Wang, Xinyue; Poslad, Stefan

2017-01-01

In an age when people are predisposed to report real-world events through their social media accounts, many researchers value the benefits of mining user generated content from social media. Compared with the traditional news media, social media services, such as Twitter, can provide more complete and timely information about the real-world events. However events are often like a puzzle and in order to solve the puzzle/understand the event, we must identify all the sub-events or pieces. Existing Twitter event monitoring systems for sub-event detection and summarization currently typically analyse events based on partial data as conventional data collection methodologies are unable to collect comprehensive event data. This results in existing systems often being unable to report sub-events in real-time and often in completely missing sub-events or pieces in the broader event puzzle. This paper proposes a Sub-event detection by real-TIme Microblog monitoring (STRIM) framework that leverages the temporal feature of an expanded set of news-worthy event content. In order to more comprehensively and accurately identify sub-events this framework first proposes the use of adaptive microblog crawling. Our adaptive microblog crawler is capable of increasing the coverage of events while minimizing the amount of non-relevant content. We then propose a stream division methodology that can be accomplished in real time so that the temporal features of the expanded event streams can be analysed by a burst detection algorithm. In the final steps of the framework, the content features are extracted from each divided stream and recombined to provide a final summarization of the sub-events. The proposed framework is evaluated against traditional event detection using event recall and event precision metrics. Results show that improving the quality and coverage of event contents contribute to better event detection by identifying additional valid sub-events. The novel combination of

Piecing together the puzzle: Improving event content coverage for real-time sub-event detection using adaptive microblog crawling.

Directory of Open Access Journals (Sweden)

Laurissa Tokarchuk

Full Text Available In an age when people are predisposed to report real-world events through their social media accounts, many researchers value the benefits of mining user generated content from social media. Compared with the traditional news media, social media services, such as Twitter, can provide more complete and timely information about the real-world events. However events are often like a puzzle and in order to solve the puzzle/understand the event, we must identify all the sub-events or pieces. Existing Twitter event monitoring systems for sub-event detection and summarization currently typically analyse events based on partial data as conventional data collection methodologies are unable to collect comprehensive event data. This results in existing systems often being unable to report sub-events in real-time and often in completely missing sub-events or pieces in the broader event puzzle. This paper proposes a Sub-event detection by real-TIme Microblog monitoring (STRIM framework that leverages the temporal feature of an expanded set of news-worthy event content. In order to more comprehensively and accurately identify sub-events this framework first proposes the use of adaptive microblog crawling. Our adaptive microblog crawler is capable of increasing the coverage of events while minimizing the amount of non-relevant content. We then propose a stream division methodology that can be accomplished in real time so that the temporal features of the expanded event streams can be analysed by a burst detection algorithm. In the final steps of the framework, the content features are extracted from each divided stream and recombined to provide a final summarization of the sub-events. The proposed framework is evaluated against traditional event detection using event recall and event precision metrics. Results show that improving the quality and coverage of event contents contribute to better event detection by identifying additional valid sub-events. The

Repeated Time-to-event Analysis of Consecutive Analgesic Events in Postoperative Pain

DEFF Research Database (Denmark)

Juul, Rasmus Vestergaard; Rasmussen, Sten; Kreilgaard, Mads

2015-01-01

BACKGROUND: Reduction in consumption of opioid rescue medication is often used as an endpoint when investigating analgesic efficacy of drugs by adjunct treatment, but appropriate methods are needed to analyze analgesic consumption in time. Repeated time-to-event (RTTE) modeling is proposed as a way...... to describe analgesic consumption by analyzing the timing of consecutive analgesic events. METHODS: Retrospective data were obtained from 63 patients receiving standard analgesic treatment including morphine on request after surgery following hip fracture. Times of analgesic events up to 96 h after surgery...... were extracted from hospital medical records. Parametric RTTE analysis was performed with exponential, Weibull, or Gompertz distribution of analgesic events using NONMEM®, version 7.2 (ICON Development Solutions, USA). The potential influences of night versus day, sex, and age were investigated...

Measurement of the underlying event using track-based event shapes in Z→l{sup +}l{sup -} events with ATLAS

Energy Technology Data Exchange (ETDEWEB)

Schulz, Holger

2014-09-11

This thesis describes a measurement of hadron-collider event shapes in proton-proton collisions at a centre of momentum energy of 7 TeV at the Large Hadron Collider (LHC) at CERN (Conseil Europeenne pour la Recherche Nucleaire) located near Geneva (Switzerland). The analysed data (integrated luminosity: 1.1 fb{sup -1}) was recorded in 2011 with the ATLAS-experiment. Events where a Z-boson was produced in the hard sub-process which subsequently decays into an electron-positron or muon-antimuon pair were selected for this analysis. The observables are calculated using all reconstructed tracks of charged particles within the acceptance of the inner detector of ATLAS except those of the leptons of the Z-decay. Thus, this is the first measurement of its kind. The observables were corrected for background processes using data-driven methods. For the correction of so-called ''pile-up'' (multiple overlapping proton-proton collisions) a novel technique was developed and successfully applied. The data was further unfolded to correct for remaining detector effects. The obtained distributions are especially sensitive to the so-called ''Underlying Event'' and can be compared with predictions of Monte-Carlo event-generators directly, i.e. without the necessity of running time-consuming simulations of the ATLAS-detector. Finally, it was tried to improve the predictions of the event generators Pythia8 and Sherpa by finding an optimised setting of relevant model parameters in a technique called ''Tuning''. It became apparent, however, that the underlying Sjoestrand-Zijl model is unable to give a good description of the measured event-shape distributions.

Safeguards Summary Event List (SSEL)

International Nuclear Information System (INIS)

1983-02-01

The Safeguards Summary Event List (SSEL) provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC). Events are described under the categories of bomb-related, intrusion, missing and/or allegedly stolen, transportation, vandalism, arson, firearms, radiological sabotage and miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

Safeguards Summary Event List (SSEL)

International Nuclear Information System (INIS)

1982-07-01

The Safeguards Summary Event List (SSEL) provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC). Events are described under the categories of bomb-related, intrusion, missing and/or allegedly stolen, transportation, vandalism, arson, firearms, sabotage and miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

Discrete-Event Simulation

Directory of Open Access Journals (Sweden)

Prateek Sharma

2015-04-01

Full Text Available Abstract Simulation can be regarded as the emulation of the behavior of a real-world system over an interval of time. The process of simulation relies upon the generation of the history of a system and then analyzing that history to predict the outcome and improve the working of real systems. Simulations can be of various kinds but the topic of interest here is one of the most important kind of simulation which is Discrete-Event Simulation which models the system as a discrete sequence of events in time. So this paper aims at introducing about Discrete-Event Simulation and analyzing how it is beneficial to the real world systems.

Measurement of the neutron fraction event-by-event in DREAM

International Nuclear Information System (INIS)

Hauptman, John; Akchurin, N; Bedeschi, F; Carosi, R; Incagli, M; Cardini, A; Ciapetti, G; Lacava, F; Pinci, D; Ferrari, R; Gaudio, G; Franchino, S; Fraternali, M; Livan, M; Negri, A; Hauptman, J; Lee, S; La Rotonda, L; Meoni, E; Policicchio, A

2011-01-01

We have measured the neutron fraction event-by-event in beam test data taken at CERN by the DREAM collaboration. I will review these measurements in the context of the importance of neutrons to future high-precision calorimetry, and bring together the data from SPACAL, the GLD compensating calorimeter, and DREAM to estimate the impact neutron fraction measurements will make on hadronic energy resolution in dual-readout calorimeters.

An improved computing method for the image edge detection

Institute of Scientific and Technical Information of China (English)

Gang Wang; Liang Xiao; Anzhi He

2007-01-01

The framework of detecting the image edge based on the sub-pixel multi-fractal measure (SPMM) is presented. The measure is defined, which gives the sub-pixel local distribution of the image gradient. The more precise singularity exponent of every pixel can be obtained by performing the SPMM analysis on the image. Using the singularity exponents and the multi-fractal spectrum of the image, the image can be segmented into a series of sets with different singularity exponents, thus the image edge can be detected automatically and easily. The simulation results show that the SPMM has higher quality factor in the image edge detection.

Machine vision for high-precision volume measurement applied to levitated containerless material processing

International Nuclear Information System (INIS)

Bradshaw, R.C.; Schmidt, D.P.; Rogers, J.R.; Kelton, K.F.; Hyers, R.W.

2005-01-01

By combining the best practices in optical dilatometry with numerical methods, a high-speed and high-precision technique has been developed to measure the volume of levitated, containerlessly processed samples with subpixel resolution. Containerless processing provides the ability to study highly reactive materials without the possibility of contamination affecting thermophysical properties. Levitation is a common technique used to isolate a sample as it is being processed. Noncontact optical measurement of thermophysical properties is very important as traditional measuring methods cannot be used. Modern, digitally recorded images require advanced numerical routines to recover the subpixel locations of sample edges and, in turn, produce high-precision measurements

The Frasnian-Famennian mass killing event(s), methods of identification and evaluation

Science.gov (United States)

Geldsetzer, H. H. J.

1988-01-01

The absence of an abnormally high number of earlier Devonian taxa from Famennian sediments was repeatedly documented and can hardly be questioned. Primary recognition of the event(s) was based on paleontological data, especially common macrofossils. Most paleontologists place the disappearance of these common forms at the gigas/triangularis contact and this boundary was recently proposed as the Frasnian-Famennian (F-F) boundary. Not unexpectedly, alternate F-F positions were suggested caused by temporary Frasnian survivors or sudden post-event radiations of new forms. Secondary supporting evidence for mass killing event(s) is supplied by trace element and stable isotope geochemistry but not with the same success as for the K/T boundary, probably due to additional 300 ma of tectonic and diagenetic overprinting. Another tool is microfacies analysis which is surprisingly rarely used even though it can explain geochemical anomalies or paleontological overlap not detectable by conventional macrofacies analysis. The combination of microfacies analysis and geochemistry was applied at two F-F sections in western Canada and showed how interdependent the two methods are. Additional F-F sections from western Canada, western United States, France, Germany and Australia were sampled or re-sampled and await geochemical/microfacies evaluation.

Safeguards Summary Event List (SSEL)

International Nuclear Information System (INIS)

1984-03-01

The Safeguards Summary Event List (SSEL) provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the U.S. Nuclear Regulatory Commission (NRC). Events are described under the categories of bomb-related, intrusion, missing and/or allegedly stolen, transportation, tampering/vandalism, arson, firearms, radiological sabotage and miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

Best Practices in Pulic Outreach Events

Science.gov (United States)

Cobb, Whitney; Buxner, Sanlyn; Shipp, Stephanie

2015-11-01

IntroductionEach year the National Aeronautics and Space Administration (NASA) sponsors public outreach events designed to increase student, educator, and general public engagement in its missions and goals. NASA SMD Education’s review of large-scale events, “Best Practices in Outreach Events,” highlighted planning and implementation best practices, which were used by the Dawn mission to strategize and implement its Ceres arrival celebration event, i C Ceres.BackgroundThe literature review focused on best identifying practices rising from evaluations of large-scale public outreach events. The following criteria guided the study:* Public, science-related events open to adults and children* Events that occurred during the last 5 years* Evaluations that included information on data collected from visitors and/or volunteers* Evaluations that specified the type of data collected, methodology, and associated resultsBest Practices: Planning and ImplementationThe literature review revealed key considerations for planning implement large-scale events. Best practices included can be pertinent for all event organizers and evaluators regardless of event size. A summary of related best practices is presented below.1) Advertise the event2) Use and advertise access to scientists* Attendees who reported an interaction with a science professional were 15% to 19% more likely to report positive learning impacts, (SFA, 2012, p. 24).3) Recruit scientists using findings such as:* High percentages of scientists (85% to 96%) from most events were interested in participating again (SFA, 2012).4) Ensure that the event is group and, particularly, child friendly5) Target specific event outcomesBest Practices Informing Real-world Planning, Implementation and EvaluationDawn mission’s collaborative design of a series of events, i C Ceres, including in-person, interactive events geared to families and live presentations, will be shared, with focus on the family event, and the evidence

Event Boundaries in Memory and Cognition.

Science.gov (United States)

Radvansky, Gabriel A; Zacks, Jeffrey M

2017-10-01

Research on event cognition is rapidly developing and is revealing fundamental aspects of human cognition. In this paper, we review recent and current work that is driving this field forward. We first outline the Event Horizon Model, which broadly describes the impact of event boundaries on cognition and memory. Then, we address recent work on event segmentation, the role of event cognition in working memory and long-term memory, including event model updating, and long term retention. Throughout we also consider how event cognition varies across individuals and groups of people and consider the neural mechanisms involved.

Application of IAEA's International Nuclear Event Scale to events at testing/research reactors in Japan

International Nuclear Information System (INIS)

Nozawa, Masao; Watanabe, Norio

1999-01-01

The International Nuclear Event Scale (INES) is a means for providing prompt, clear and consistent information related to nuclear events and facilitating communication between the nuclear community, the media and the public on such events. This paper describes the INES rating process for events at testing/research reactors and nuclear fuel processing facilities and experience on the application of the INES scale in Japan. (author)

TEMAC, Top Event Sensitivity Analysis

International Nuclear Information System (INIS)

Iman, R.L.; Shortencarier, M.J.

1988-01-01

1 - Description of program or function: TEMAC is designed to permit the user to easily estimate risk and to perform sensitivity and uncertainty analyses with a Boolean expression such as produced by the SETS computer program. SETS produces a mathematical representation of a fault tree used to model system unavailability. In the terminology of the TEMAC program, such a mathematical representation is referred to as a top event. The analysis of risk involves the estimation of the magnitude of risk, the sensitivity of risk estimates to base event probabilities and initiating event frequencies, and the quantification of the uncertainty in the risk estimates. 2 - Method of solution: Sensitivity and uncertainty analyses associated with top events involve mathematical operations on the corresponding Boolean expression for the top event, as well as repeated evaluations of the top event in a Monte Carlo fashion. TEMAC employs a general matrix approach which provides a convenient general form for Boolean expressions, is computationally efficient, and allows large problems to be analyzed. 3 - Restrictions on the complexity of the problem - Maxima of: 4000 cut sets, 500 events, 500 values in a Monte Carlo sample, 16 characters in an event name. These restrictions are implemented through the FORTRAN 77 PARAMATER statement

Estimating the impact of extreme events on crude oil price. An EMD-based event analysis method

Energy Technology Data Exchange (ETDEWEB)

Zhang, Xun; Wang, Shouyang [Institute of Systems Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190 (China); School of Mathematical Sciences, Graduate University of Chinese Academy of Sciences, Beijing 100190 (China); Yu, Lean [Institute of Systems Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190 (China); Lai, Kin Keung [Department of Management Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon (China)

2009-09-15

The impact of extreme events on crude oil markets is of great importance in crude oil price analysis due to the fact that those events generally exert strong impact on crude oil markets. For better estimation of the impact of events on crude oil price volatility, this study attempts to use an EMD-based event analysis approach for this task. In the proposed method, the time series to be analyzed is first decomposed into several intrinsic modes with different time scales from fine-to-coarse and an average trend. The decomposed modes respectively capture the fluctuations caused by the extreme event or other factors during the analyzed period. It is found that the total impact of an extreme event is included in only one or several dominant modes, but the secondary modes provide valuable information on subsequent factors. For overlapping events with influences lasting for different periods, their impacts are separated and located in different modes. For illustration and verification purposes, two extreme events, the Persian Gulf War in 1991 and the Iraq War in 2003, are analyzed step by step. The empirical results reveal that the EMD-based event analysis method provides a feasible solution to estimating the impact of extreme events on crude oil prices variation. (author)

Estimating the impact of extreme events on crude oil price. An EMD-based event analysis method

International Nuclear Information System (INIS)

Zhang, Xun; Wang, Shouyang; Yu, Lean; Lai, Kin Keung

2009-01-01

The impact of extreme events on crude oil markets is of great importance in crude oil price analysis due to the fact that those events generally exert strong impact on crude oil markets. For better estimation of the impact of events on crude oil price volatility, this study attempts to use an EMD-based event analysis approach for this task. In the proposed method, the time series to be analyzed is first decomposed into several intrinsic modes with different time scales from fine-to-coarse and an average trend. The decomposed modes respectively capture the fluctuations caused by the extreme event or other factors during the analyzed period. It is found that the total impact of an extreme event is included in only one or several dominant modes, but the secondary modes provide valuable information on subsequent factors. For overlapping events with influences lasting for different periods, their impacts are separated and located in different modes. For illustration and verification purposes, two extreme events, the Persian Gulf War in 1991 and the Iraq War in 2003, are analyzed step by step. The empirical results reveal that the EMD-based event analysis method provides a feasible solution to estimating the impact of extreme events on crude oil prices variation. (author)

Safeguards Summary Event List (SSEL)

International Nuclear Information System (INIS)

1991-07-01

The Safeguards Summary Event List (SSEL) provides brief summaries of several hundred safeguards-related events involving nuclear material or facilities regulated by the US Nuclear Regulatory Commission (NRC). Because of public interest, the Miscellaneous category includes a few events which involve either source material, byproduct material, or natural uranium which are exempt from safeguards requirements. Events are described under the categories of bomb-related, intrusion, missing and/or allegedly stolen, transportation, tampering/vandalism, arson, firearms, radiological sabotage, nonradiological sabotage, pre-1990 alcohol and drugs (involving reactor operators, security force members, or management persons), and miscellaneous. The information contained in the event descriptions is derived primarily from official NRC reporting channels

EVENT PLANNING USING FUNCTION ANALYSIS

Energy Technology Data Exchange (ETDEWEB)

Lori Braase; Jodi Grgich

2011-06-01

Event planning is expensive and resource intensive. Function analysis provides a solid foundation for comprehensive event planning (e.g., workshops, conferences, symposiums, or meetings). It has been used at Idaho National Laboratory (INL) to successfully plan events and capture lessons learned, and played a significant role in the development and implementation of the “INL Guide for Hosting an Event.” Using a guide and a functional approach to planning utilizes resources more efficiently and reduces errors that could be distracting or detrimental to an event. This integrated approach to logistics and program planning – with the primary focus on the participant – gives us the edge.

Event-by-Event Simulation of Induced Fission

Energy Technology Data Exchange (ETDEWEB)

Vogt, R; Randrup, J

2007-12-13

We are developing a novel code that treats induced fission by statistical (or Monte-Carlo) simulation of individual decay chains. After its initial excitation, the fissionable compound nucleus may either deexcite by evaporation or undergo binary fission into a large number of fission channels each with different energetics involving both energy dissipation and deformed scission prefragments. After separation and Coulomb acceleration, each fission fragment undergoes a succession of individual (neutron) evaporations, leading to two bound but still excited fission products (that may further decay electromagnetically and, ultimately, weakly), as well as typically several neutrons. (The inclusion of other possible ejectiles is planned.) This kind of approach makes it possible to study more detailed observables than could be addressed with previous treatments which have tended to focus on average quantities. In particular, any type of correlation observable can readily be extracted from a generated set of events. With a view towards making the code practically useful in a variety of applications, emphasis is being put on making it numerically efficient so that large event samples can be generated quickly. In its present form, the code can generate one million full events in about 12 seconds on a MacBook laptop computer. The development of this qualitatively new tool is still at an early stage and quantitative reproduction of existing data should not be expected until a number of detailed refinement have been implemented.

Event-by-Event Simulation of Induced Fission

Science.gov (United States)

Vogt, Ramona; Randrup, Jørgen

2008-04-01

We are developing a novel code that treats induced fission by statistical (or Monte-Carlo) simulation of individual decay chains. After its initial excitation, the fissionable compound nucleus may either de-excite by evaporation or undergo binary fission into a large number of fission channels each with different energetics involving both energy dissipation and deformed scission pre-fragments. After separation and Coulomb acceleration, each fission fragment undergoes a succession of individual (neutron) evaporations, leading to two bound but still excited fission products (that may further decay electromagnetically and, ultimately, weakly), as well as typically several neutrons. (The inclusion of other possible ejectiles is planned.) This kind of approach makes it possible to study more detailed observables than could be addressed with previous treatments which have tended to focus on average quantities. In particular, any type of correlation observable can readily be extracted from a generated set of events. With a view towards making the code practically useful in a variety of applications, emphasis is being put on making it numerically efficient so that large event samples can be generated quickly. In its present form, the code can generate one million full events in about 12 seconds on a MacBook laptop computer. The development of this qualitatively new tool is still at an early stage and quantitative reproduction of existing data should not be expected until a number of detailed refinement have been implemented.

Event-by-Event Simulation of Induced Fission

International Nuclear Information System (INIS)

Vogt, Ramona; Randrup, Joergen

2008-01-01

We are developing a novel code that treats induced fission by statistical (or Monte-Carlo) simulation of individual decay chains. After its initial excitation, the fissionable compound nucleus may either de-excite by evaporation or undergo binary fission into a large number of fission channels each with different energetics involving both energy dissipation and deformed scission pre-fragments. After separation and Coulomb acceleration, each fission fragment undergoes a succession of individual (neutron) evaporations, leading to two bound but still excited fission products (that may further decay electromagnetically and, ultimately, weakly), as well as typically several neutrons. (The inclusion of other possible ejectiles is planned.) This kind of approach makes it possible to study more detailed observables than could be addressed with previous treatments which have tended to focus on average quantities. In particular, any type of correlation observable can readily be extracted from a generated set of events. With a view towards making the code practically useful in a variety of applications, emphasis is being put on making it numerically efficient so that large event samples can be generated quickly. In its present form, the code can generate one million full events in about 12 seconds on a MacBook laptop computer. The development of this qualitatively new tool is still at an early stage and quantitative reproduction of existing data should not be expected until a number of detailed refinement have been implemented

Event-by-Event Simulation of Induced Fission

International Nuclear Information System (INIS)

Vogt, R; Randrup, J

2007-01-01

We are developing a novel code that treats induced fission by statistical (or Monte-Carlo) simulation of individual decay chains. After its initial excitation, the fissionable compound nucleus may either deexcite by evaporation or undergo binary fission into a large number of fission channels each with different energetics involving both energy dissipation and deformed scission prefragments. After separation and Coulomb acceleration, each fission fragment undergoes a succession of individual (neutron) evaporations, leading to two bound but still excited fission products (that may further decay electromagnetically and, ultimately, weakly), as well as typically several neutrons. (The inclusion of other possible ejectiles is planned.) This kind of approach makes it possible to study more detailed observables than could be addressed with previous treatments which have tended to focus on average quantities. In particular, any type of correlation observable can readily be extracted from a generated set of events. With a view towards making the code practically useful in a variety of applications, emphasis is being put on making it numerically efficient so that large event samples can be generated quickly. In its present form, the code can generate one million full events in about 12 seconds on a MacBook laptop computer. The development of this qualitatively new tool is still at an early stage and quantitative reproduction of existing data should not be expected until a number of detailed refinement have been implemented

Negated bio-events: analysis and identification

Science.gov (United States)

2013-01-01

Background Negation occurs frequently in scientific literature, especially in biomedical literature. It has previously been reported that around 13% of sentences found in biomedical research articles contain negation. Historically, the main motivation for identifying negated events has been to ensure their exclusion from lists of extracted interactions. However, recently, there has been a growing interest in negative results, which has resulted in negation detection being identified as a key challenge in biomedical relation extraction. In this article, we focus on the problem of identifying negated bio-events, given gold standard event annotations. Results We have conducted a detailed analysis of three open access bio-event corpora containing negation information (i.e., GENIA Event, BioInfer and BioNLP’09 ST), and have identified the main types of negated bio-events. We have analysed the key aspects of a machine learning solution to the problem of detecting negated events, including selection of negation cues, feature engineering and the choice of learning algorithm. Combining the best solutions for each aspect of the problem, we propose a novel framework for the identification of negated bio-events. We have evaluated our system on each of the three open access corpora mentioned above. The performance of the system significantly surpasses the best results previously reported on the BioNLP’09 ST corpus, and achieves even better results on the GENIA Event and BioInfer corpora, both of which contain more varied and complex events. Conclusions Recently, in the field of biomedical text mining, the development and enhancement of event-based systems has received significant interest. The ability to identify negated events is a key performance element for these systems. We have conducted the first detailed study on the analysis and identification of negated bio-events. Our proposed framework can be integrated with state-of-the-art event extraction systems. The

Multi-Unit Initiating Event Analysis for a Single-Unit Internal Events Level 1 PSA

Energy Technology Data Exchange (ETDEWEB)

Kim, Dong San; Park, Jin Hee; Lim, Ho Gon [KAERI, Daejeon (Korea, Republic of)

2016-05-15

The Fukushima nuclear accident in 2011 highlighted the importance of considering the risks from multi-unit accidents at a site. The ASME/ANS probabilistic risk assessment (PRA) standard also includes some requirements related to multi-unit aspects, one of which (IE-B5) is as follows: 'For multi-unit sites with shared systems, DO NOT SUBSUME multi-unit initiating events if they impact mitigation capability [1].' However, the existing single-unit PSA models do not explicitly consider multi-unit initiating events and hence systems shared by multiple units (e.g., alternate AC diesel generator) are fully credited for the single unit and ignores the need for the shared systems by other units at the same site [2]. This paper describes the results of the multi-unit initiating event (IE) analysis performed as a part of the at-power internal events Level 1 probabilistic safety assessment (PSA) for an OPR1000 single unit ('reference unit'). In this study, a multi-unit initiating event analysis for a single-unit PSA was performed, and using the results, dual-unit LOOP initiating event was added to the existing PSA model for the reference unit (OPR1000 type). Event trees were developed for dual-unit LOOP and dual-unit SBO which can be transferred from dual- unit LOOP. Moreover, CCF basic events for 5 diesel generators were modelled. In case of simultaneous SBO occurrences in both units, this study compared two different assumptions on the availability of the AAC D/G. As a result, when dual-unit LOOP initiating event was added to the existing single-unit PSA model, the total CDF increased by 1∼ 2% depending on the probability that the AAC D/G is available to a specific unit in case of simultaneous SBO in both units.

TECHNOLOGY OF EDUCATIONAL EVENTS DESIGNING

Directory of Open Access Journals (Sweden)

N. V. Volkova

2017-01-01

Full Text Available The aim of the article is to prove and disclose the essence of the author’s technology of educational events designing.Methodology and methods of research. Methodological basis of work is humanitarian approach. The method of pedagogical modeling was used for the model development of educational events influence on pedagogical activity formation. The content analysis of texts descriptions, case-study method, expert estimations of event projects were applied as the main methods of efficiency confirmation of the technology of educational events design.Results and scientific novelty. The characteristics of an educational event are emphasized by means of an empirical way: opening (what a person opens for himself; generation (a result of a personal action; and participation in creation of something "new" (new communications, relations and experience. The structure of technology of educational events design including work with concepts (an educational event, substantial and procedural components is presented. The technology of educational events designing is considered as the process of the well-grounded choice of designing technologies, mutual activity, pedagogical communication, components of educational activity: contents, methods, means, and organizational forms depending on educational aims due to age-specific peculiarities of participants of the educational event. The main conditions providing successful use of the technology are the involvement into joint cognitive activity of all its participants and importance of the events for each of them that qualitatively change the nature of a cognitive process and generate real transformations of the reality.Practical significance. The author’s experience in teaching testifies to introduction of the module «Technology of Design of Educational Events» into the basic educational subject-module «Design Competence of the Teacher» (degree program «Pedagogical Education», considering this module as

The effect of event repetition on the production of story grammar in children's event narratives.

Science.gov (United States)

Feltis, Brooke B; Powell, Martine B; Roberts, Kim P

2011-03-01

This study examined the effect of event repetition on the amount and nature of story-grammar produced by children when recalling the event. Children aged 4 years (N=50) and 7 years (N=56) participated in either 1 or 6 occurrences of a highly similar event where details varied across the occurrences. Half the children in each age and event group recalled the last/single occurrence 5-6 days later and the other half recalled the last/single occurrence after 5-6 weeks (the final and single occurrence was the same). Children's free recall responses were classified according to the number and proportion of story-grammar elements (Stein & Glenn, 1979-setting, initiating event, internal response, plan, attempt, direct consequence, and resolution) as well as the prevalence of causal links between the individual story-grammar elements. More story-grammar detail and more links between individual story-grammar elements were reported about the final compared to single occurrence. The amount of story-grammar increased with age and decreased over time. Further, an interaction was revealed such that the effect of retention interval on the production of story-grammar was negligible for older children who experienced the repeated event. Event repetition has a beneficial effect on the production of children's story-grammar content in situations where event details varied from occasion to occasion. This study highlights the importance of eliciting free recall when conducting evidential interviews with child witnesses about repeated events. Copyright © 2011 Elsevier Ltd. All rights reserved.

Wavelet spectra of JACEE events

International Nuclear Information System (INIS)

Suzuki, Naomichi; Biyajima, Minoru; Ohsawa, Akinori.

1995-01-01

Pseudo-rapidity distributions of two high multiplicity events Ca-C and Si-AgBr observed by the JACEE are analyzed by a wavelet transform. Wavelet spectra of those events are calculated and compared with the simulation calculations. The wavelet spectrum of the Ca-C event somewhat resembles that simulated with the uniform random numbers. That of Si-AgBr event, however, is not reproduced by simulation calculations with Poisson random numbers, uniform random numbers, or a p-model. (author)

Underlying Event studies and Monte Carlo tunes for inelastic pp events with the ATLAS detector

CERN Document Server

Nurse, E; The ATLAS collaboration

2010-01-01

Studies of the momentum flow in inelastic collisions at 900 GeV and 7 TeV recorded with a minimum bias trigger strategy are reported. A single high pT track is selected, and the distribution of other tracks in the event is evaluated relative to this reference track. The evolution of the charged momentum flow in the rest of the event, as a function of the pT of the reference track, gives important information about the transition from minimum bias event structure to the full underlying event observed in high-pT collision events. Results are presented after correction and unfolding of detector effects to allow simpler comparison to Monte Carlo models. In addition, the PYTHIA Monte Carlo generator has been tuned to ATLAS measurements at 900 GeV and 7 TeV. Standard distributions from Minimum Bias events, as well as the Underlying Event studies are included in the first tunes to ATLAS measurements at the LHC. The tunes aim for one consistent description of the new measurements as well as data from the Tevatron and...

ATLAS event at 13 TeV - Highest mass dijets resonance event in 2015 data

CERN Multimedia

ATLAS Collaboration

2015-01-01

The highest-mass, central dijet event passing the dijet resonance selection collected in 2015 (Event 1273922482, Run 280673) : the two central high-pT jets have an invariant mass of 6.9 TeV, the two leading jets have a pT of 3.2 TeV. The missing transverse momentum in this event is 46 GeV.

Recurring events - Volume 2

International Nuclear Information System (INIS)

2003-04-01

The feedback of operating experience from nuclear power plants (NPP) is intended to help avoid occurrence or recurrence of safety significant events. Regulatory bodies, and utilities operating nuclear power plants, have established operating experience feedback systems since the beginning of commercial nuclear power production. Well-established operating experience feedback systems exist on national and international level. An example of an international system is the Incident Reporting System (IRS) jointly operated by the International Atomic Energy Agency (IAEA) and the Nuclear Energy Agency (NEA). There also are systems maintained by the operating organizations, including the World Association of Nuclear Operators (WANO), and owner groups of different NPP vendors. Committee on the Safety of Nuclear Installations (CSNI) Working Group on Operating Experience (WGOE; formerly Principal Working Group No. 1, PWG1) carried out a study on recurring events some years ago. This report, published in 1999, highlighted some areas of safety significance involving recurrent events in different NPPs around the world. Based on the important findings of this report, CSNI requested two additional studies: 1. first an international workshop should be organized and second, 2. a task group should be established to develop a second report on the topic and to evaluate the findings of the workshop. The workshop, hosted by the Swiss Regulatory Authority, HSK, was held in Switzerland in March 2002. It was attended by 32 experts representing the regulatory, nuclear power plant, vendor, and international agency communities. Several insights and recommendations were presented and are integrated in this report with respect to causes of recurring events: - Operating experience feedback processes had not always been effective, that is, the existing operating experiences had not been effectively applied, - Actions to be taken were not implemented in a timely manner, - The root cause was not

OAE: The Ontology of Adverse Events.

Science.gov (United States)

He, Yongqun; Sarntivijai, Sirarat; Lin, Yu; Xiang, Zuoshuang; Guo, Abra; Zhang, Shelley; Jagannathan, Desikan; Toldo, Luca; Tao, Cui; Smith, Barry

2014-01-01

A medical intervention is a medical procedure or application intended to relieve or prevent illness or injury. Examples of medical interventions include vaccination and drug administration. After a medical intervention, adverse events (AEs) may occur which lie outside the intended consequences of the intervention. The representation and analysis of AEs are critical to the improvement of public health. The Ontology of Adverse Events (OAE), previously named Adverse Event Ontology (AEO), is a community-driven ontology developed to standardize and integrate data relating to AEs arising subsequent to medical interventions, as well as to support computer-assisted reasoning. OAE has over 3,000 terms with unique identifiers, including terms imported from existing ontologies and more than 1,800 OAE-specific terms. In OAE, the term 'adverse event' denotes a pathological bodily process in a patient that occurs after a medical intervention. Causal adverse events are defined by OAE as those events that are causal consequences of a medical intervention. OAE represents various adverse events based on patient anatomic regions and clinical outcomes, including symptoms, signs, and abnormal processes. OAE has been used in the analysis of several different sorts of vaccine and drug adverse event data. For example, using the data extracted from the Vaccine Adverse Event Reporting System (VAERS), OAE was used to analyse vaccine adverse events associated with the administrations of different types of influenza vaccines. OAE has also been used to represent and classify the vaccine adverse events cited in package inserts of FDA-licensed human vaccines in the USA. OAE is a biomedical ontology that logically defines and classifies various adverse events occurring after medical interventions. OAE has successfully been applied in several adverse event studies. The OAE ontological framework provides a platform for systematic representation and analysis of adverse events and of the factors (e

The CBM first-level event selector

Energy Technology Data Exchange (ETDEWEB)

Cuveland, Jan de; Lindenstruth, Volker [Frankfurt Institute for Advanced Studies, Goethe University, Frankfurt (Germany)

2015-07-01

The CBM experiment currently under construction at GSI/FAIR is designed to study QCD predictions at high baryon densities. The CBM First-Level Event Selector (FLES) is the central event selection system of the experiment. Designed as a high-performance computer cluster, its task is an online analysis of the physics data including full event reconstruction at an incoming data rate exceeding 1 TByte/s. The CBM detector systems are free-running and self-triggered, delivering time-stamped data streams. As there is no inherent event separation, traditional approaches for global event building and event selection are not directly applicable. Instead of event building, the FLES combines the data from approximately 1000 input links to self-contained, overlapping processing intervals and distributes them to compute nodes. It employs a high-bandwidth InfiniBand network as well as dedicated custom FPGA input boards providing time-addressed access to buffered data. Subsequently, specialized event selection algorithms analyze these processing intervals in 4-D, identify events, and select those relevant for storage depending on the chosen CBM setup and selection scenario. This presentation outlines the design of the CBM First-level Event Selector and summarizes the results from first prototype systems.

RETRIEVAL EVENTS EVALUATION

International Nuclear Information System (INIS)

Wilson, T.

1999-01-01

The purpose of this analysis is to evaluate impacts to the retrieval concept presented in the Design Analysis ''Retrieval Equipment and Strategy'' (Reference 6), from abnormal events based on Design Basis Events (DBE) and Beyond Design Basis Events (BDBE) as defined in two recent analyses: (1) DBE/Scenario Analysis for Preclosure Repository Subsurface Facilities (Reference 4); and (2) Preliminary Preclosure Design Basis Event Calculations for the Monitored Geologic Repository (Reference 5) The objective of this task is to determine what impacts the DBEs and BDBEs have on the equipment developed for retrieval. The analysis lists potential impacts and recommends changes to be analyzed in subsequent design analyses for developed equipment, or recommend where additional equipment may be needed, to allow retrieval to be performed in all DBE or BDBE situations. This analysis supports License Application design and therefore complies with the requirements of Systems Description Document input criteria comparison as presented in Section 7, Conclusions. In addition, the analysis discusses the impacts associated with not using concrete inverts in the emplacement drifts. The ''Retrieval Equipment and Strategy'' analysis was based on a concrete invert configuration in the emplacement drift. The scope of the analysis, as presented in ''Development Plan for Retrieval Events Evaluation'' (Reference 3) includes evaluation and criteria of the following: Impacts to retrieval from the emplacement drift based on DBE/BDBEs, and changes to the invert configuration for the preclosure period. Impacts to retrieval from the main drifts based on DBE/BDBEs for the preclosure period

Uncoupling of satellite DNA and centromeric function in the genus Equus.

Science.gov (United States)

Piras, Francesca M; Nergadze, Solomon G; Magnani, Elisa; Bertoni, Livia; Attolini, Carmen; Khoriauli, Lela; Raimondi, Elena; Giulotto, Elena

2010-02-12

In a previous study, we showed that centromere repositioning, that is the shift along the chromosome of the centromeric function without DNA sequence rearrangement, has occurred frequently during the evolution of the genus Equus. In this work, the analysis of the chromosomal distribution of satellite tandem repeats in Equus caballus, E. asinus, E. grevyi, and E. burchelli highlighted two atypical features: 1) several centromeres, including the previously described evolutionary new centromeres (ENCs), seem to be devoid of satellite DNA, and 2) satellite repeats are often present at non-centromeric termini, probably corresponding to relics of ancestral now inactive centromeres. Immuno-FISH experiments using satellite DNA and antibodies against the kinetochore protein CENP-A demonstrated that satellite-less primary constrictions are actually endowed with centromeric function. The phylogenetic reconstruction of centromere repositioning events demonstrates that the acquisition of satellite DNA occurs after the formation of the centromere during evolution and that centromeres can function over millions of years and many generations without detectable satellite DNA. The rapidly evolving Equus species gave us the opportunity to identify different intermediate steps along the full maturation of ENCs.

Uncoupling of satellite DNA and centromeric function in the genus Equus.

Directory of Open Access Journals (Sweden)

Francesca M Piras

2010-02-01

Full Text Available In a previous study, we showed that centromere repositioning, that is the shift along the chromosome of the centromeric function without DNA sequence rearrangement, has occurred frequently during the evolution of the genus Equus. In this work, the analysis of the chromosomal distribution of satellite tandem repeats in Equus caballus, E. asinus, E. grevyi, and E. burchelli highlighted two atypical features: 1 several centromeres, including the previously described evolutionary new centromeres (ENCs, seem to be devoid of satellite DNA, and 2 satellite repeats are often present at non-centromeric termini, probably corresponding to relics of ancestral now inactive centromeres. Immuno-FISH experiments using satellite DNA and antibodies against the kinetochore protein CENP-A demonstrated that satellite-less primary constrictions are actually endowed with centromeric function. The phylogenetic reconstruction of centromere repositioning events demonstrates that the acquisition of satellite DNA occurs after the formation of the centromere during evolution and that centromeres can function over millions of years and many generations without detectable satellite DNA. The rapidly evolving Equus species gave us the opportunity to identify different intermediate steps along the full maturation of ENCs.

A new palatal distractor device for bodily movement of maxillary bones by rigid self-locking miniplates and screws system.

Science.gov (United States)

Cortese, Antonio; Savastano, Mauro; Cantone, Antonio; Claudio, Pier Paolo

2013-07-01

A new palatal distractor device for bodily movement of the maxillary bones after complete segmented Le Fort I osteotomy for 1-stage transversal distraction and tridimensional repositioning on 1 patient is presented. The new distractor has an intrinsic tridimensional rigidity also in the fixation system by self-locking miniplates and screws for better control of the 2 maxillary fragments during distraction. Le Fort I distraction and repositioning procedure in association with a bilateral sagittal split osteotomy were performed on 1 patient with complete solution of the cross-bite and class III malocclusion. Results of dental and cephalometric analysis performed before surgery (T1), after surgery and distraction time (T2), and 18 months after surgery and orthodontic appliance removal (T3) are reported. No complications were encountered using the new distractor device. Advantages of this device and technique are presented including improved rigidity of both distraction (jackscrew) and fixation (4 self-locking miniplates and screws) systems resulting in complete control of the position of the 2 maxillary fragments during distraction and surgery. In addition, this new device allows resuming palatal distraction in the event of cross-bite relapse without causing dental-related problems or the risks of screw slackening.

Integrated Initiating Event Performance Indicators

International Nuclear Information System (INIS)

S. A. Eide; Dale M. Rasmuson; Corwin L. Atwood

2005-01-01

The U.S. Nuclear Regulatory Commission Industry Trends Program (ITP) collects and analyses industry-wide data, assesses the safety significance of results, and communicates results to Congress and other stakeholders. This paper outlines potential enhancements in the ITP to comprehensively cover the Initiating Events Cornerstone of Safety. Future work will address other cornerstones of safety. The proposed Tier 1 activity involves collecting data on ten categories of risk-significant initiating events, trending the results, and comparing early performance with prediction limits (allowable numbers of events, above which NRC action may occur). Tier 1 results would be used to monitor industry performance at the level of individual categories of initiating events. The proposed Tier 2 activity involves integrating the information for individual categories of initiating events into a single risk-based indicator, termed the Baseline Risk Index for Initiating Events or BRIIE. The BRIIE would be evaluated yearly and compared against a threshold. BRIIE results would be reported to Congress on a yearly basis

De-Virtualizing Social Events: Understanding the Gap between Online and Offline Participation for Event Invitations

OpenAIRE

Huang, Ai-Ju; Wang, Hao-Chuan; Yuan, Chien Wen

2013-01-01

One growing use of computer-based communication media is for gathering people to initiate or sustain social events. Although the use of computer-mediated communication and social network sites such as Facebook for event promotion is becoming popular, online participation in an event does not always translate to offline attendance. In this paper, we report on an interview study of 31 participants that examines how people handle online event invitations and what influences their online and offl...

ATLAS event at 13 TeV - Highest mass dijets angular event in 2015 data

CERN Multimedia

ATLAS Collaboration

2015-01-01

The highest-mass dijet event passing the angular selection collected in 2015 (Event 478442529, Run 280464): the two central high-pT jets have an invariant mass of 7.9 TeV, the three leading jets have a pT of 1.99, 1.86 and 0.74 TeV respectively. The missing transverse momentum in this event is 46 GeV

LHCb Online event processing and filtering

CERN Document Server

Alessio, F; Brarda, L; Frank, M; Franek, B; Galli, D; Gaspar, C; Van Herwijnen, E; Jacobsson, R; Jost, B; Köstner, S; Moine, G; Neufeld, N; Somogyi, P; Stoica, R; Suman, S

2008-01-01

The first level trigger of LHCb accepts one million events per second. After preprocessing in custom FPGA-based boards these events are distributed to a large farm of PC-servers using a high-speed Gigabit Ethernet network. Synchronisation and event management is achieved by the Timing and Trigger system of LHCb. Due to the complex nature of the selection of B-events, which are the main interest of LHCb, a full event-readout is required. Event processing on the servers is parallelised on an event basis. The reduction factor is typically 1/500. The remaining events are forwarded to a formatting layer, where the raw data files are formed and temporarily stored. A small part of the events is also forwarded to a dedicated farm for calibration and monitoring. The files are subsequently shipped to the CERN Tier0 facility for permanent storage and from there to the various Tier1 sites for reconstruction. In parallel files are used by various monitoring and calibration processes running within the LHCb Online system. ...

Extinction Events Can Accelerate Evolution

DEFF Research Database (Denmark)

Lehman, Joel; Miikkulainen, Risto

2015-01-01

Extinction events impact the trajectory of biological evolution significantly. They are often viewed as upheavals to the evolutionary process. In contrast, this paper supports the hypothesis that although they are unpredictably destructive, extinction events may in the long term accelerate...... evolution by increasing evolvability. In particular, if extinction events extinguish indiscriminately many ways of life, indirectly they may select for the ability to expand rapidly through vacated niches. Lineages with such an ability are more likely to persist through multiple extinctions. Lending...... computational support for this hypothesis, this paper shows how increased evolvability will result from simulated extinction events in two computational models of evolved behavior. The conclusion is that although they are destructive in the short term, extinction events may make evolution more prolific...

New PHOBOS results on event-by-event fluctuations

Science.gov (United States)

Alver, B.; Back, B. B.; Baker, M. D.; Ballintijn, M.; Barton, D. S.; Betts, R. R.; Bickley, A. A.; Bindel, R.; Budzanowski, A.; Busza, W.; Carroll, A.; Chai, Z.; Chetluru, V.; Decowski, M. P.; García, E.; Gburek, T.; George, N.; Gulbrandsen, K.; Gushue, S.; Halliwell, C.; Hamblen, J.; Heintzelman, G. A.; Henderson, C.; Harnarine, I.; Hofman, D. J.; Hollis, R. S.; Hołyński, R.; Holzman, B.; Iordanova, A.; Johnson, E.; Kane, J. L.; Khan, N.; Kucewicz, W.; Kulinich, P.; Kuo, C. M.; Li, W.; Lin, W. T.; Loizides, C.; Manly, S.; Mignerey, A. C.; Nouicer, R.; Olszewski, A.; Pak, R.; Park, I. C.; Reed, C.; Remsberg, L. P.; Reuter, M.; Richardson, E.; Roland, C.; Roland, G.; Rosenberg, L.; Sagerer, J.; Sarin, P.; Sawicki, P.; Sedykh, I.; Skulski, W.; Smith, C. E.; Stankiewicz, M. A.; Steinberg, P.; Stephans, G. S. F.; Sukhanov, A.; Szostak, A.; Tang, J.-L.; Tonjes, M. B.; Trzupek, A.; Vale, C.; van Nieuwenhuizen, G. J.; Vaurynovich, S. S.; Verdier, R.; Veres, G. I.; Walters, P.; Wenger, E.; Willhelm, D.; Wolfs, F. L. H.; Wosiek, B.; Woźniak, K.; Wuosmaa, A. H.; Wyngaardt, S.; Wysłouch, B.

2006-04-01

We present new results from the PHOBOS experiment at RHIC on event-by-event fluctuations of particle multiplicities and angular distributions in nucleus-nucleus collisions at RHIC. Our data for Au+Au collisions at √sNN = 200 GeV show that at a level of 10-4 or less, no rare, large-amplitude fluctuations in the total multiplicity distributions or the shape of the pseudorapidity distributions are observed. We however find significant short-range multiplicity correlations in these data, that can be described as particle production in clusters. In Cu+Cu collisions, we observe large final-state azimuthal anisotropies ν2. A common scaling behavior for Cu+Cu and Au+Au for these anisotropies emerges when fluctuations in the initial state geometry are taken into account.

Revisiting event horizon finders

International Nuclear Information System (INIS)

Cohen, Michael I; Pfeiffer, Harald P; Scheel, Mark A

2009-01-01

Event horizons are the defining physical features of black hole spacetimes, and are of considerable interest in studying black hole dynamics. Here, we reconsider three techniques to find event horizons in numerical spacetimes: integrating geodesics, integrating a surface, and integrating a level-set of surfaces over a volume. We implement the first two techniques and find that straightforward integration of geodesics backward in time is most robust. We find that the exponential rate of approach of a null surface towards the event horizon of a spinning black hole equals the surface gravity of the black hole. In head-on mergers we are able to track quasi-normal ringing of the merged black hole through seven oscillations, covering a dynamic range of about 10 5 . Both at late times (when the final black hole has settled down) and at early times (before the merger), the apparent horizon is found to be an excellent approximation of the event horizon. In the head-on binary black hole merger, only some of the future null generators of the horizon are found to start from past null infinity; the others approach the event horizons of the individual black holes at times far before merger.

Potential interest to combine an intensity modulated conformal radiotherapy (I.M.C.R.T.) with a daily repositioning on intra-prostate implants to reduce sexual toxicity induced by exclusive irradiation of prostate cancers; Interets potentiels de combiner une radiotherapie de conformation avec modulation d'intensite (RCMI) avec un repositionnement journalier sur implants intraprostatiques pour reduire la toxicite sexuelle induite par l'irradiation exclusive des cancers de prostate

Energy Technology Data Exchange (ETDEWEB)

Chapet, O.; Sotton, M.P.; Vial, L.; Belliere, A.; Ardiet, J.M.; Mornex, F.; Sentenac, I.; Romestaing, P. [Centre Hospitalier Lyon-Sud, Dept. de Radiotherapie-oncologie, 69 - Pierre-Benite (France); Bouffard, J. [Centre Hospitalier Lyon-Sud, Service de Radiologie, 69 - Pierre-Benite (France)

2007-11-15

A reduction in margins defining the forecast target volume thanks to a daily repositioning on intra prostate implants would reduce the doses delivered to the penis bulb, corpora cavernosa penis and a. pudendae internae left and right. An optimization of the I.M.C.R.T. on the same anatomical structures amplifies this earnings. The combination of the two could improve the sexual preservation and be proposed for patients with favourable stage prostate cancer. A study of Phase 2 begins soon. (N.C.)

The ATLAS Event Service: A New Approach to Event Processing

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00070566; De, Kaushik; Guan, Wen; Maeno, Tadashi; Nilsson, Paul; Oleynik, Danila; Panitkin, Sergey; Tsulaia, Vakhtang; van Gemmeren, Peter; Wenaus, Torre

2015-01-01

The ATLAS Event Service (ES) implements a new fine grained approach to HEP event processing, designed to be agile and efficient in exploiting transient, short-lived resources such as HPC hole-filling, spot market commercial clouds, and volunteer computing. Input and output control and data flows, bookkeeping, monitoring, and data storage are all managed at the event level in an implementation capable of supporting ATLAS-scale distributed processing throughputs (about 4M CPU-hours/day). Input data flows utilize remote data repositories with no data locality or pre­staging requirements, minimizing the use of costly storage in favor of strongly leveraging powerful networks. Object stores provide a highly scalable means of remotely storing the quasi-continuous, fine grained outputs that give ES based applications a very light data footprint on a processing resource, and ensure negligible losses should the resource suddenly vanish. We will describe the motivations for the ES system, its unique features and capabi...

Estimation of the isothermal compressibility from event-by-event multiplicity fluctuation studies

Directory of Open Access Journals (Sweden)

Mukherjee Maitreyee

2018-01-01

Full Text Available The first estimation of the isothermal compressibility (kT of matter is presented for a wide range of collision energies from √sNN = 7.7 GeV to 2.76 TeV. kT is estimated with the help of event-byevent charged particle multiplicity fluctuations from experiment. Dynamical fluctuations are extracted by removing the statistical fluctuations obtained from the participant model. kT is also estimated from event generators AMPT, UrQMD, EPOS and a hadron resonance gas model. The values of isothermal compressibility are estimated for the Large Hadron Collider (LHC energies with the help of the event generators.

Identifying jet quantum numbers event by event

International Nuclear Information System (INIS)

Teper, M.J.

1979-12-01

A method is proposed to identify the parton that gives rise to any particular jet. The method improves with the number of particles in the jet, and should indicate which of the jets in a three jet event at PETRA is the gluon jet. (author)

Characterization of major pollution events (dust, haze, and two festival events) at Agra, India.

Science.gov (United States)

Pachauri, Tripti; Singla, Vyoma; Satsangi, Aparna; Lakhani, Anita; Kumari, K Maharaj

2013-08-01

Total suspended particulate (TSP) samples were collected during dust, haze, and two festival events (Holi and Diwali) from February 2009 to June 2010. Pollutant gases (NO2, SO2, and O3) along with the meteorological parameters were also measured during the four pollution events at Agra. The concentration of pollutant gases decreases during dust events (DEs), but the levels of the gases increase during other pollution events indicating the impact of anthropogenic emissions. The mass concentrations were about two times higher during pollution events than normal days (NDs). High TSP concentrations during Holi and Diwali events may be attributed to anthropogenic activities while increased combustion sources in addition to stagnant meteorological conditions contributed to high TSP mass during haze events. On the other hand, long-range transport of atmospheric particles plays a major role during DEs. In the dust samples, Ca(2+), Cl(-), NO3 (-), and SO4 (2-) were the most abundant ions and Ca(2+) alone accounted for 22 % of the total ionic mass, while during haze event, the concentrations of secondary aerosols species, viz., NO3 (-), SO4 (2-), and NH4 (+), were 3.6, 3.3, and 5.1 times higher than the normal days. During Diwali, SO4 (2-) concentration (17.8 μg m(-3)) was highest followed by NO3 (-), K(+), and Cl(-) while the Holi samples were strongly enriched with Cl(-) and K(+) which together made up 32.7 % of the total water-soluble ions. The ion balances indicate that the haze samples were acidic. On the other hand, Holi, Diwali, and DE samples were enriched with cations. The carbonaceous aerosol shows strong variation with the highest concentration during Holi followed by haze, Diwali, DEs, and NDs. However, the secondary organic carbon concentration follows the order haze > DEs > Diwali > Holi > NDs. The scanning electron microscope/EDX results indicate that KCl and carbon-rich particles were more dominant during Holi and haze events while DE samples were enriched

Aspirin and the risk of cardiovascular events in atherosclerosis patients with and without prior ischemic events.

Science.gov (United States)

Bavry, Anthony A; Elgendy, Islam Y; Elbez, Yedid; Mahmoud, Ahmed N; Sorbets, Emmanuel; Steg, Philippe Gabriel; Bhatt, Deepak L

2017-09-01

The benefit of aspirin among patients with stable atherosclerosis without a prior ischemic event is not well defined. Aspirin would be of benefit in outpatients with atherosclerosis with prior ischemic events, but not in those without ischemic events. Subjects from the Reduction of Atherothrombosis for Continued Health registry were divided according to prior ischemic event (n =21 724) vs stable atherosclerosis, but no prior ischemic event (n = 11 872). Analyses were propensity score matched. Aspirin use was updated at each clinic visit and considered as a time-varying covariate. The primary outcome was the first occurrence of cardiovascular death, myocardial infarction, or stroke. In the group with a prior ischemic event, aspirin use was associated with a marginally lower risk of the primary outcome at a median of 41 months (hazard ratio [HR]: 0.81, 95% confidence interval [CI]: 0.65-1.01, P = 0.06). In the group without a prior ischemic event, aspirin use was not associated with a lower risk of the primary outcome at a median of 36 months (HR: 1.03, 95% CI: 0.73-1.45, P = 0.86). In this observational analysis of outpatients with stable atherosclerosis, aspirin was marginally beneficial among patients with a prior ischemic event; however, there was no apparent benefit among those with no prior ischemic event. © 2017 Wiley Periodicals, Inc.

Modeling Documents with Event Model

Directory of Open Access Journals (Sweden)

Longhui Wang

2015-08-01

Full Text Available Currently deep learning has made great breakthroughs in visual and speech processing, mainly because it draws lessons from the hierarchical mode that brain deals with images and speech. In the field of NLP, a topic model is one of the important ways for modeling documents. Topic models are built on a generative model that clearly does not match the way humans write. In this paper, we propose Event Model, which is unsupervised and based on the language processing mechanism of neurolinguistics, to model documents. In Event Model, documents are descriptions of concrete or abstract events seen, heard, or sensed by people and words are objects in the events. Event Model has two stages: word learning and dimensionality reduction. Word learning is to learn semantics of words based on deep learning. Dimensionality reduction is the process that representing a document as a low dimensional vector by a linear mode that is completely different from topic models. Event Model achieves state-of-the-art results on document retrieval tasks.

TOURISMOLOGICAL CLASSIFICATION OF SPORTING EVENTS

Directory of Open Access Journals (Sweden)

Željko Bjeljac

2017-04-01

Full Text Available Sporting events are programs, which are dominated by creative and complex facilities, primarily sports, but also recreation and entertainment. As such, they achieve tourism effects and goals and have a socio-economic importance for the city, region or state. Depending on the size and importance of sports event, sport has a different role in the context of promoting tourist destination, as well as different values. Each sport discipline has its own criteria by which athletes are ranked individually or as team. The subject of the research is to determine the criteria for the categorization of sporting events, in order to determine the importance of sporting events as an element of the tourist offer (individually or as part of a tourist destination. Also, this paper’s results present a comparative analysis of similar methodologies for the categorization of sporting events. Based on the research presented in the paper, there are four groups of criteria: economic, media, social and environmental. Together with this, paper gives the classification of traditional sporting events in the case of Serbia, dividing them in four groups.

DESIGNING AN EVENT EXTRACTION SYSTEM

Directory of Open Access Journals (Sweden)

Botond BENEDEK

2017-06-01

Full Text Available In the Internet world, the amount of information available reaches very high quotas. In order to find specific information, some tools were created that automatically scroll through the existing web pages and update their databases with the latest information on the Internet. In order to systematize the search and achieve a result in a concrete form, another step is needed for processing the information returned by the search engine and generating the response in a more organized form. Centralizing events of a certain type is useful first of all for creating a news service. Through this system we are pursuing a knowledge - events from the Internet documents - extraction system. The system will recognize events of a certain type (weather, sports, politics, text data mining, etc. depending on how it will be trained (the concept it has in the dictionary. These events can be provided to the user, or it can also extract the context in which the event occurred, to indicate the initial form in which the event was embedded.

Intermediate mass dimuon events

International Nuclear Information System (INIS)

Moser, H.-G.

1985-01-01

We report the observation of 67 dimuon events at the CERN p anti p collider with the UA1 detector. The events will be interpreted in terms of the Drell-Yan mechanism, J/PSI and UPSILON decays and heavy flavour production. (author)

Event-by-Event Hydrodynamics+Jet Energy Loss: A Solution to the R_{AA}⊗v_{2} Puzzle.

Science.gov (United States)

Noronha-Hostler, Jacquelyn; Betz, Barbara; Noronha, Jorge; Gyulassy, Miklos

2016-06-24

High p_{T}>10  GeV elliptic flow, which is experimentally measured via the correlation between soft and hard hadrons, receives competing contributions from event-by-event fluctuations of the low-p_{T} elliptic flow and event-plane angle fluctuations in the soft sector. In this Letter, a proper account of these event-by-event fluctuations in the soft sector, modeled via viscous hydrodynamics, is combined with a jet-energy-loss model to reveal that the positive contribution from low-p_{T} v_{2} fluctuations overwhelms the negative contributions from event-plane fluctuations. This leads to an enhancement of high-p_{T}>10  GeV elliptic flow in comparison to previous calculations and provides a natural solution to the decade-long high-p_{T} R_{AA}⊗v_{2} puzzle. We also present the first theoretical calculation of high-p_{T} v_{3}, which is shown to be compatible with current LHC data. Furthermore, we discuss how short-wavelength jet-medium physics can be deconvoluted from the physics of soft, bulk event-by-event flow observables using event-shape engineering techniques.

The Agency of Event

DEFF Research Database (Denmark)

Nicholas, Paul; Tamke, Martin; Riiber, Jacob

2014-01-01

This paper explores the notion of agency within event-based models. We present an event-based modeling approach that links interdependent generative, analytic and decision making sub-models within a system of exchange. Two case study projects demonstrate the underlying modeling concepts and metho...

Ground calibration of the spatial response and quantum efficiency of the CdZnTe hard x-ray detectors for NuSTAR

Science.gov (United States)

Grefenstette, Brian W.; Bhalerao, Varun; Cook, W. Rick; Harrison, Fiona A.; Kitaguchi, Takao; Madsen, Kristin K.; Mao, Peter H.; Miyasaka, Hiromasa; Rana, Vikram

2017-08-01

Pixelated Cadmium Zinc Telluride (CdZnTe) detectors are currently flying on the Nuclear Spectroscopic Telescope ARray (NuSTAR) NASA Astrophysics Small Explorer. While the pixel pitch of the detectors is ≍ 605 μm, we can leverage the detector readout architecture to determine the interaction location of an individual photon to much higher spatial accuracy. The sub-pixel spatial location allows us to finely oversample the point spread function of the optics and reduces imaging artifacts due to pixelation. In this paper we demonstrate how the sub-pixel information is obtained, how the detectors were calibrated, and provide ground verification of the quantum efficiency of our Monte Carlo model of the detector response.

Events as a Framework for Tourist Destination Branding – Case Studies of Two Cultural Events in Croatia

Directory of Open Access Journals (Sweden)

Klara Trošt

2012-04-01

Full Text Available Events have become an increasingly significant component of destination branding. Many destinations throughout the world have developed events portfolios as a strategic initiative to attract tourists and to reinforce their brand. In this paper, the focus of research will be on tourist destination branding by means of events. The relationship between events and destination branding is examined through six phases of the process of building a destination brand identity with the use of events. When it comes to destination branding, a need for an analysis of strategic documents of destination development imposes because event tourism strategies help destinations plan how to use events in a tourism role. The purpose of this study is to examine which factors are of the top priorities when using events as a marketing approach. The method of case study will be used, by which two cultural events which take place in the Republic of Croatia will be analyzed, namely, “Špancirfest” in Varaždin and “Trka na prstenac” in Barban. Varaždin and Barban are on different levels in their branding work. The different sizes and locations of the destinations naturally affect the operating procedures. This article may be of interest to destination marketers and event organizers, especially in developing destinations which intend to differentiate themselves from the competitive market.

ATLAS event at 13 TeV - 21 May 2015 - Run 265545 Event 5720351

CERN Multimedia

ATLAS Collaboration

2015-01-01

Displays of a proton-proton collision event recorded by ATLAS on 21 May 2015, at 13 TeV collision energy. Tracks reconstructed from hits in the inner tracking detector are shown to originate from two interaction points, indicating a pile-up event.

LHCb Online event processing and filtering

Science.gov (United States)

Alessio, F.; Barandela, C.; Brarda, L.; Frank, M.; Franek, B.; Galli, D.; Gaspar, C.; Herwijnen, E. v.; Jacobsson, R.; Jost, B.; Köstner, S.; Moine, G.; Neufeld, N.; Somogyi, P.; Stoica, R.; Suman, S.

2008-07-01

The first level trigger of LHCb accepts one million events per second. After preprocessing in custom FPGA-based boards these events are distributed to a large farm of PC-servers using a high-speed Gigabit Ethernet network. Synchronisation and event management is achieved by the Timing and Trigger system of LHCb. Due to the complex nature of the selection of B-events, which are the main interest of LHCb, a full event-readout is required. Event processing on the servers is parallelised on an event basis. The reduction factor is typically 1/500. The remaining events are forwarded to a formatting layer, where the raw data files are formed and temporarily stored. A small part of the events is also forwarded to a dedicated farm for calibration and monitoring. The files are subsequently shipped to the CERN Tier0 facility for permanent storage and from there to the various Tier1 sites for reconstruction. In parallel files are used by various monitoring and calibration processes running within the LHCb Online system. The entire data-flow is controlled and configured by means of a SCADA system and several databases. After an overview of the LHCb data acquisition and its design principles this paper will emphasize the LHCb event filter system, which is now implemented using the final hardware and will be ready for data-taking for the LHC startup. Control, configuration and security aspects will also be discussed.

LHCb Online event processing and filtering

International Nuclear Information System (INIS)

Alessio, F; Barandela, C; Brarda, L; Frank, M; Gaspar, C; Herwijnen, E v; Jacobsson, R; Jost, B; Koestner, S; Moine, G; Neufeld, N; Somogyi, P; Stoica, R; Suman, S; Franek, B; Galli, D

2008-01-01

The first level trigger of LHCb accepts one million events per second. After preprocessing in custom FPGA-based boards these events are distributed to a large farm of PC-servers using a high-speed Gigabit Ethernet network. Synchronisation and event management is achieved by the Timing and Trigger system of LHCb. Due to the complex nature of the selection of B-events, which are the main interest of LHCb, a full event-readout is required. Event processing on the servers is parallelised on an event basis. The reduction factor is typically 1/500. The remaining events are forwarded to a formatting layer, where the raw data files are formed and temporarily stored. A small part of the events is also forwarded to a dedicated farm for calibration and monitoring. The files are subsequently shipped to the CERN Tier0 facility for permanent storage and from there to the various Tier1 sites for reconstruction. In parallel files are used by various monitoring and calibration processes running within the LHCb Online system. The entire data-flow is controlled and configured by means of a SCADA system and several databases. After an overview of the LHCb data acquisition and its design principles this paper will emphasize the LHCb event filter system, which is now implemented using the final hardware and will be ready for data-taking for the LHC startup. Control, configuration and security aspects will also be discussed

Event visualization in ATLAS

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00211497; The ATLAS collaboration; Boudreau, Joseph; Konstantinidis, Nikolaos; Martyniuk, Alex; Moyse, Edward; Thomas, Juergen; Waugh, Ben; Yallup, David

2017-01-01

At the beginning, HEP experiments made use of photographical images both to record and store experimental data and to illustrate their findings. Then the experiments evolved and needed to find ways to visualize their data. With the availability of computer graphics, software packages to display event data and the detector geometry started to be developed. Here, an overview of the usage of event display tools in HEP is presented. Then the case of the ATLAS experiment is considered in more detail and two widely used event display packages are presented, Atlantis and VP1, focusing on the software technologies they employ, as well as their strengths, differences and their usage in the experiment: from physics analysis to detector development, and from online monitoring to outreach and communication. Towards the end, the other ATLAS visualization tools will be briefly presented as well. Future development plans and improvements in the ATLAS event display packages will also be discussed.

The CMS Event Builder

CERN Document Server

Brigljevic, V; Cano, E; Cittolin, Sergio; Csilling, Akos; Gigi, D; Glege, F; Gómez-Reino, Robert; Gulmini, M; Gutleber, J; Jacobs, C; Kozlovszky, Miklos; Larsen, H; Magrans de Abril, Ildefons; Meijers, F; Meschi, E; Murray, S; Oh, A; Orsini, L; Pollet, L; Rácz, A; Samyn, D; Scharff-Hansen, P; Schwick, C; Sphicas, Paris; ODell, V; Suzuki, I; Berti, L; Maron, G; Toniolo, N; Zangrando, L; Ninane, A; Erhan, S; Bhattacharya, S; Branson, J G

2003-01-01

The data acquisition system of the CMS experiment at the Large Hadron Collider will employ an event builder which will combine data from about 500 data sources into full events at an aggregate throughput of 100 GByte/s. Several architectures and switch technologies have been evaluated for the DAQ Technical Design Report by measurements with test benches and by simulation. This paper describes studies of an EVB test-bench based on 64 PCs acting as data sources and data consumers and employing both Gigabit Ethernet and Myrinet technologies as the interconnect. In the case of Ethernet, protocols based on Layer-2 frames and on TCP/IP are evaluated. Results from ongoing studies, including measurements on throughput and scaling are presented. The architecture of the baseline CMS event builder will be outlined. The event builder is organised into two stages with intelligent buffers in between. The first stage contains 64 switches performing a first level of data concentration by building super-fragments from fragmen...

Visual pattern discovery in timed event data

Science.gov (United States)

Schaefer, Matthias; Wanner, Franz; Mansmann, Florian; Scheible, Christian; Stennett, Verity; Hasselrot, Anders T.; Keim, Daniel A.

2011-01-01

Business processes have tremendously changed the way large companies conduct their business: The integration of information systems into the workflows of their employees ensures a high service level and thus high customer satisfaction. One core aspect of business process engineering are events that steer the workflows and trigger internal processes. Strict requirements on interval-scaled temporal patterns, which are common in time series, are thereby released through the ordinal character of such events. It is this additional degree of freedom that opens unexplored possibilities for visualizing event data. In this paper, we present a flexible and novel system to find significant events, event clusters and event patterns. Each event is represented as a small rectangle, which is colored according to categorical, ordinal or intervalscaled metadata. Depending on the analysis task, different layout functions are used to highlight either the ordinal character of the data or temporal correlations. The system has built-in features for ordering customers or event groups according to the similarity of their event sequences, temporal gap alignment and stacking of co-occurring events. Two characteristically different case studies dealing with business process events and news articles demonstrate the capabilities of our system to explore event data.

Event Registration System for INR Linac

International Nuclear Information System (INIS)

Grekhov, O.V.; Drugakov, A.N.; Kiselev, Yu.V.

2006-01-01

The software of the Event registration system for the linear accelerators is described. This system allows receiving of the information on changes of operating modes of the accelerator and supervising of hundreds of key parameters of various systems of the accelerator. The Event registration system consists of the source and listeners of events. The sources of events are subroutines built in existing ACS Linac. The listeners of events are software Supervisor and Client ERS. They are used for warning the operator about change controlled parameter of the accelerator