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Sample records for submicromolar ic50 values

  1. ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform.

    Science.gov (United States)

    Li, Ming; Chou, Judy; King, Kristopher W; Jing, Jing; Wei, Dong; Yang, Liyu

    2015-02-01

    IC50 and EC50 values are commonly used to evaluate drug potency. Mass spectrometry (MS)-centric bioanalytical and biomarker labs are now conducting IC50/EC50 assays, which, if done manually, are tedious and error-prone. Existing bioanalytical sample preparation automation systems cannot meet IC50/EC50 assay throughput demand. A general-purpose, automation-assisted IC50/EC50 assay platform was developed to automate the calculations of spiking solutions and the matrix solutions preparation scheme, the actual spiking and matrix solutions preparations, as well as the flexible sample extraction procedures after incubation. In addition, the platform also automates the data extraction, nonlinear regression curve fitting, computation of IC50/EC50 values, graphing, and reporting. The automation-assisted IC50/EC50 assay platform can process the whole class of assays of varying assay conditions. In each run, the system can handle up to 32 compounds and up to 10 concentration levels per compound, and it greatly improves IC50/EC50 assay experimental productivity and data processing efficiency. © 2014 Society for Laboratory Automation and Screening.

  2. Nonlinear concentration gradients regulated by the width of channels for observation of half maximal inhibitory concentration (IC50) of transporter proteins.

    Science.gov (United States)

    Abe, Yuta; Kamiya, Koki; Osaki, Toshihisa; Sasaki, Hirotaka; Kawano, Ryuji; Miki, Norihisa; Takeuchi, Shoji

    2015-08-21

    This paper describes a simple microfluidic device that can generate nonlinear concentration gradients. We changed the "width" of channels that can drastically shorten the total microfluidic channel length and simplify the microfluidic network design rather than the "length" of channels. The logarithmic concentration gradients generated by the device were in good agreement with those obtained by simulation. Using this device, we evaluated a probable IC50 value of the ABC transporter proteins by the competitive transport assays at five different logarithmic concentrations. This probable IC50 value was in good agreement with an IC50 value (0.92 μM) obtained at the diluted concentrations of seven points.

  3. A novel application of t-statistics to objectively assess the quality of IC50 fits for P-glycoprotein and other transporters.

    Science.gov (United States)

    O'Connor, Michael; Lee, Caroline; Ellens, Harma; Bentz, Joe

    2015-02-01

    Current USFDA and EMA guidance for drug transporter interactions is dependent on IC50 measurements as these are utilized in determining whether a clinical interaction study is warranted. It is therefore important not only to standardize transport inhibition assay systems but also to develop uniform statistical criteria with associated probability statements for generation of robust IC50 values, which can be easily adopted across the industry. The current work provides a quantitative examination of critical factors affecting the quality of IC50 fits for P-gp inhibition through simulations of perfect data with randomly added error as commonly observed in the large data set collected by the P-gp IC50 initiative. The types of errors simulated were (1) variability in replicate measures of transport activity; (2) transformations of error-contaminated transport activity data prior to IC50 fitting (such as performed when determining an IC50 for inhibition of P-gp based on efflux ratio); and (3) the lack of well defined "no inhibition" and "complete inhibition" plateaus. The effect of the algorithm used in fitting the inhibition curve (e.g., two or three parameter fits) was also investigated. These simulations provide strong quantitative support for the recommendations provided in Bentz et al. (2013) for the determination of IC50 values for P-gp and demonstrate the adverse effect of data transformation prior to fitting. Furthermore, the simulations validate uniform statistical criteria for robust IC50 fits in general, which can be easily implemented across the industry. A calibration of the t-statistic is provided through calculation of confidence intervals associated with the t-statistic.

  4. Validation and Clinical Utility of the hERG IC50:Cmax Ratio to Determine the Risk of Drug-Induced Torsades de Pointes: A Meta-Analysis.

    Science.gov (United States)

    Lehmann, David F; Eggleston, William D; Wang, Dongliang

    2018-03-01

    Use of the QT interval corrected for heart rate (QTc) on the electrocardiogram (ECG) to predict torsades de pointes (TdP) risk from culprit drugs is neither sensitive nor specific. The ratio of the half-maximum inhibitory concentration of the hERG channel (hERG IC50) to the peak serum concentration of unbound drug (C max ) is used during drug development to screen out chemical entities likely to cause TdP. To validate the use of the hERG IC50:C max ratio to predict TdP risk from a culprit drug by its correlation with TdP incidence. Medline (between 1966 and March 2017) was accessed for hERG IC50 and C max values from the antihistamine, fluoroquinolone, and antipsychotic classes to identify cases of drug-induced TdP. Exposure to a culprit drug was estimated from annual revenues reported by the manufacturer. Inclusion criteria for TdP cases were provision of an ECG tracing that demonstrated QTc prolongation with TdP and normal serum values of potassium, calcium, and magnesium. Cases reported in patients with a prior rhythm disturbance and those involving a drug interaction were excluded. The Meta-Analysis of Observational Studies in Epidemiology checklist was used for epidemiological data extraction by two authors. Negligible risk drugs were defined by an hERG IC50:C max ratio that correlated with less than a 5% chance of one TdP event for every 100 million exposures (relative risk [RR] 1.0). The hERG IC50:C max ratio correlated with TdP risk (0.312; 95% confidence interval 0.205-0.476, pratio of 80 (RR 1.0). The RR from olanzapine is on par with loratadine; ziprasidone is comparable with ciprofloxacin. Drugs with an RR greater than 50 include astemizole, risperidone, haloperidol, and thioridazine. The hERG IC50:C max ratio was correlated with TdP incidence for culprit drugs. This validation provides support for the potential use of the hERG IC50:C max ratio for clinical decision making in instances of drug selection where TdP risk is a concern. © 2018

  5. Determining the size and concentration dependence of gold nanoparticles in vitro cytotoxicity (IC50) test using WST-1 assay

    International Nuclear Information System (INIS)

    Rosli, Nur Shafawati binti; Rahman, Azhar Abdul; Aziz, Azlan Abdul; Shamsuddin, Shaharum

    2015-01-01

    Gold nanoparticles (AuNPs) received a great deal of attention for biomedical applications, especially in diagnostic imaging and therapeutics. Even though AuNPs have potential benefits in biomedical applications, the impact of AuNPs on human and environmental health still remains unclear. The use of AuNPs which is a high-atomic-number materials, provide advantages in terms of radiation dose enhancement. However, before this can become a clinical reality, cytotoxicity of the AuNPs has to be carefully evaluated. Cytotoxicity test is a rapid, standardized test that is very sensitive to determine whether the nanoparticles produced are harmful or benign on cellular components. In this work the size and concentration dependence of AuNPs cytotoxicity in breast cancer cell lines (MCF-7) are tested by using WST-1 assay. The sizes of AuNPs tested were 13 nm, 50 nm, and 70 nm. The cells were seeded in the 96-well plate and were treated with different concentrations of AuNPs by serial dilution for each size of AuNPs. The high concentration of AuNPs exhibit lower cell viability compared to low concentration of AuNPs. We quantified the toxicity of AuNPs in MCF-7 cell lines by determining the IC 50 values in WST-1 assays. The IC 50 values (inhibitory concentrations that effected 50% growth inhibition) of 50 nm AuNPs is lower than 13 nm and 70 nm AuNPs. Mean that, 50nm AuNPs are more toxic to the MCF-7 cells compared to smaller and larger sizes AuNPs. The presented results clearly indicate that the cytotoxicity of AuNPs depend not only on the concentration, but also the size of the nanoparticles

  6. Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug- Drug Interaction Risk Assessment Decision Criterias

    NARCIS (Netherlands)

    Bentz, J.; O'Connor, M.P.; Bednarczyk, D.; Coleman, J.; Lee, C.; Palm, J.; Pak, Y.A.; Perloff, E.S.; Reyner, E.; Balimane, P.; Brännström, M.; Chu, X.; Funk, C.; Guo, A.; Hanna, I.; Herédi-Szabó, K.; Hillgren, K.; Li, L.; Hollnack-Pusch, E.; Jamei, M.; Lin, X.; Mason, A.K.; Neuhoff, S.; Patel, A.; Podila, L.; Plise, E.; Rajaraman, G.; Salphati, L.; Sands, E.; Taub, M.E.; Taur, J.-S.; Weitz, D.; Wortelboer, H.M.; Xia, C.Q.; Xiao, G.; Yabut, J.; Yamagata, T.; Zhang, L.; Ellens, H.

    2013-01-01

    A P-glycoprotein (P-gp) IC50 working group was established with 23 participating pharmaceutical and contract research laboratories and one academic institution to assess interlaboratory variability in P-gp IC 50 determinations. Each laboratory followed its in-house protocol to determine in vitro

  7. Dual Incorporation of the in vitro Data (IC50) and in vivo (Cmax) Data for the Prediction of Area Under the Curve (AUC) for Statins using Regression Models Developed for Either Pravastatin or Simvastatin.

    Science.gov (United States)

    Srinivas, N R

    2016-08-01

    Linear regression models utilizing a single time point (Cmax) has been reported for pravastatin and simvastatin. A new model was developed for the prediction of AUC of statins that utilized the slopes of the above 2 models, with pharmacokinetic (Cmax) and a pharmacodynamic (IC50 value) components for the statins. The prediction of AUCs for various statins (pravastatin, atorvastatin, simvastatin and rosuvastatin) was carried out using the newly developed dual pharmacokinetic and pharmacodynamic model. Generally, the AUC predictions were contained within 0.5 to 2-fold difference of the observed AUC suggesting utility of the new models. The root mean square error predictions wereAUC for statins. Such a new concept as described in the work may have utility in both drug discovery and development stages. © Georg Thieme Verlag KG Stuttgart · New York.

  8. In vitro neuraminidase inhibitory concentration (IC50) of four neuraminidase inhibitors in the Japanese 2016-17 season: Comparison with the 2010-11 to 2015-16 seasons.

    Science.gov (United States)

    Ikematsu, Hideyuki; Kawai, Naoki; Iwaki, Norio; Kashiwagi, Seizaburo; Ishikawa, Yusuke; Yamaguchi, Hiroki; Shiosakai, Kazuhito

    2018-05-11

    To assess the extent of susceptibility to the four most commonly used neuraminidase inhibitors (NAIs) in the viruses epidemic in the 2016-17 Japanese influenza season, we measured the 50% inhibitory concentration (IC 50 ) of these NAIs for influenza virus isolates from patients and compared them with the results from the 2010-11 to 2015-16 seasons. Viral isolation was done with specimens obtained prior to treatment, and the type and subtype was determined by RT-PCR using type- and subtype-specific primers. The IC 50 was determined by a neuraminidase inhibition assay using a fluorescent substrate. A total of 276 virus isolates, 6 A (H1N1)pdm09 (2.2%), 249 A (H3N2) (90.2%), and 21 B (7.6%), had the IC 50 measured for the four NAIs. B isolates included 11 (52.4%), 9 (42.9%), and one (4.8%) of the Victoria, Yamagata, and undetermined strains, respectively. No A (H1N1)pdm09 with highly reduced sensitivity for oseltamivir was found in the 2016-17 season. No isolate with highly reduced sensitivity to the four NAIs have been found for A (H3N2) or B from the 2010-11 to 2016-17 seasons. No significant trend of increase or decrease was found in the geometric mean IC 50 s of the four NAIs during the seven studied seasons. These results indicate that the sensitivity to the four commonly used NAIs has been maintained and that any change in the effectiveness of these NAIs would be minute. Common usage of NAIs for patient treatment has not been a driving force in the selection of NAI resistant viruses. Copyright © 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  9. Triorganotin Derivatives Induce Cell Death Effects on L1210 Leukemia Cells at Submicromolar Concentrations Independently of P-glycoprotein Expression

    Directory of Open Access Journals (Sweden)

    Viera Bohacova

    2018-05-01

    Full Text Available The acceleration of drug efflux activity realized by plasma membrane transporters in neoplastic cells, particularly by P-glycoprotein (P-gp, ABCB1 member of the ABC transporter family, represents a frequently observed molecular cause of multidrug resistance (MDR. This multiple resistance represents a real obstacle in the effective chemotherapy of neoplastic diseases. Therefore, identifying cytotoxic substances that are also effective in P-gp overexpressing cells may be useful for the rational design of substances for the treatment of malignancies with developed MDR. Here, we showed that triorganotin derivatives—tributyltin-chloride (TBT-Cl, tributyltin-bromide (TBT-Br, tributyltin-iodide (TBT-I and tributyltin-isothiocyanate (TBT-NCS or triphenyltin-chloride (TPT-Cl and triphenyltin-isothiocyanate (TPT-NCS—could induce the death of L1210 mice leukemia cells at a submicromolar concentration independently of P-gp overexpression. The median lethal concentration obtained for triorganotin derivatives did not exceed 0.5 µM in the induction of cell death of either P-gp negative or P-gp positive L1210 cells. Apoptosis related to regulatory pathway of Bcl-2 family proteins seems to be the predominant mode of cell death in either P-gp negative or P-gp positive L1210 cells. TBT-Cl and TBT-Br were more efficient with L1210 cells overexpressing P-gp than with their counterpart P-gp negative cells. In contrast, TBT-I and TPT-NCS induced a more pronounced cell death effect on P-gp negative cells than on P-gp positive cells. Triorganotin derivatives did not affect P-gp efflux in native cells measured by calcein retention within the cells. Taken together, we assumed that triorganotin derivatives represent substances suitable for suppressing the viability of P-gp positive malignant cells.

  10. Biological activities and nutritional value of Tapinanthus bangwensis ...

    African Journals Online (AJOL)

    The ethyl acetate and dichloromethane fractions exhibited significant cytotoxic effects towards HeLa cells with IC50 values of 24.25 and 24.43 μg/ml respectively. In the DPPH assay, the ethyl acetate fraction showed the highest activity while the butanol fraction showed the highest activity in the metal chelating and the lipid ...

  11. New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.

    Science.gov (United States)

    Durcik, Martina; Lovison, Denise; Skok, Žiga; Durante Cruz, Cristina; Tammela, Päivi; Tomašič, Tihomir; Benedetto Tiz, Davide; Draskovits, Gábor; Nyerges, Ákos; Pál, Csaba; Ilaš, Janez; Peterlin Mašič, Lucija; Kikelj, Danijel; Zidar, Nace

    2018-06-25

    The ATP binding site located on the subunit B of DNA gyrase is an attractive target for the development of new antibacterial agents. In recent decades, several small-molecule inhibitor classes have been discovered but none has so far reached the market. We present here the discovery of a promising new series of N-phenylpyrrolamides with low nanomolar IC 50 values against DNA gyrase, and submicromolar IC 50 values against topoisomerase IV from Escherichia coli and Staphylococcus aureus. The most potent compound in the series has an IC 50 value of 13 nM against E. coli gyrase. Minimum inhibitory concentrations (MICs) against Gram-positive bacteria are in the low micromolar range. The oxadiazolone derivative 11a, with an IC 50 value of 85 nM against E. coli DNA gyrase displays the most potent antibacterial activity, with MIC values of 1.56 μM against Enterococcus faecalis, and 3.13 μM against wild type S. aureus, methicillin-resistant S. aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). The activity against wild type E. coli in the presence of efflux pump inhibitor phenylalanine-arginine β-naphthylamide (PAβN) is 4.6 μM. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  12. Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines.

    Science.gov (United States)

    Vandekerckhove, Stéphanie; Müller, Christian; Vogt, Dieter; Lategan, Carmen; Smith, Peter J; Chibale, Kelly; De Kimpe, Norbert; D'hooghe, Matthias

    2013-01-01

    A variety of 5-, 6- and 8-(4-aminobutyloxy)quinolines as novel oxygen analogues of known 4- and 8-(4-aminobutylamino)quinoline antimalarial drugs was generated from hydroxyquinolines through a three-step approach with a rhodium-catalyzed hydroformylation as the key step. Antiplasmodial assays of these new quinolines revealed micromolar potency for all representatives against a chloroquine-sensitive strain of Plasmodium falciparum, and three compounds showed submicromolar activity against a chloroquine-resistant strain of P. falciparum with IC(50)-values ranging between 150 and 680 nM. Copyright © 2012 Elsevier Ltd. All rights reserved.

  13. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase

    Directory of Open Access Journals (Sweden)

    Xiaofei Jiang

    2017-01-01

    Full Text Available Jatrorrhizine was considered as one of the active constituents of Coptis chinensis Franch. Herein, jatrorrhizine derivatives with substituted amino groups linked at the 3-position were designed, synthesized, and biologically evaluated as inhibitors of acetylcholinesterase. Jatrorrhizine derivatives inhibited the activity of acetylcholinesterase (AChE to a greater extent than the lead compound jatrorrhizine. All these jatrorrhizine derivatives were proved to be potent inhibitors of acetylcholinesterase (AChE with submicromolar IC50 values, but less sensitive to butyrylcholinesterase (BuChE, which suggests that these jatrorrhizine derivatives are selective for AChE/BuChE. Compound 3g gave the most potent inhibitor activity for AChE (IC50 = 0.301 μM, which is greater than the lead compound jatrorrhizine. All these results demonstrated that these jatrorrhizine derivatives are potential inhibitors for AChE.

  14. Valuing Essays: Essaying Values

    Science.gov (United States)

    Badley, Graham

    2010-01-01

    The essay regularly comes under attack. It is criticised for being rigidly linear rather than flexible and reflective. I first challenge this view by examining reasons why the essay should be valued as an important genre. Secondly, I propose that in using the essay form students and academics necessarily exemplify their own critical values. Essays…

  15. Novel 5-Fluorouracil Derivatives: Synthesis and Cytotoxic Activity of 2-Butoxy-4-Substituted 5-Fluoropyrimidines

    International Nuclear Information System (INIS)

    Sun, Jian; Zhou, Wei; Hu, Weixiao; Shan, Shang; Zhang, Shijie; Li, Haibo

    2013-01-01

    Twenty two new 5-fluorouracil (5-FU) derivatives, 2-butoxy-4-substituted 5-fluoropyrimidines, were synthesized and characterized by IR, 1 H NMR, MS, HRMS. All compounds were preliminarily evaluated by MTT assay on human liver BEL-7402 cancer cell line in vitro. Ten compounds were selected to test their cytotoxic activity against A549, HL-60 and MCF-7 cancer cell lines in vitro. These compounds were more sensitive to BEL-7402 than other cell lines, particularly, cytotoxic activity of compounds 6b, 6d-f, 6p, 6s-u were in sub-micromolar scale. The highest cytotoxic potency against A549, HL-60 and MCF-7 was shown by 2-butoxy-4-chloro-5-fluoropyrimidine (5) with IC 50 values of 0.10, 1.66 and 0.59 μM, respectively. Compounds 6d and 6e were effective against MCF-7 with IC 50 9.73 μM and HL-60 with IC 50 8.83 μM, respectively

  16. The potential medicinal value of plants from Asteraceae family with antioxidant defense enzymes as biological targets.

    Science.gov (United States)

    Koc, Suheda; Isgor, Belgin S; Isgor, Yasemin G; Shomali Moghaddam, Naznoosh; Yildirim, Ozlem

    2015-05-01

    Plants and most of the plant-derived compounds have long been known for their potential pharmaceutical effects. They are well known to play an important role in the treatment of several diseases from diabetes to various types of cancers. Today most of the clinically effective pharmaceuticals are developed from plant-derived ancestors in the history of medicine. The aim of this study was to evaluate the free radical scavenging activity and total phenolic and flavonoid contents of methanol, ethanol, and acetone extracts from flowers and leaves of Onopordum acanthium L., Carduus acanthoides L., Cirsium arvense (L.) Scop., and Centaurea solstitialis L., all from the Asteraceae family, for investigating their potential medicinal values of biological targets that are participating in the antioxidant defense system such as catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPx). In this study, free radical scavenging activity and total phenolic and flavonoid contents of the plant samples were assayed by DPPH, Folin-Ciocalteu, and aluminum chloride colorimetric methods. Also, the effects of extracts on CAT, GST, and GPx enzyme activities were investigated. The highest phenolic and flavonoid contents were detected in the acetone extract of C. acanthoides flowers, with 90.305 mg GAE/L and 185.43 mg Q/L values, respectively. The highest DPPH radical scavenging was observed with the methanol leaf extracts of C. arvense with an IC50 value of 366 ng/mL. The maximum GPx and GST enzyme inhibition activities were observed with acetone extracts from the flower of C. solstitialis with IC50 values of 79 and 232 ng/mL, respectively.

  17. The Value of Value

    DEFF Research Database (Denmark)

    Sørensen, Asger

    parts of business ethics given prominence to especially one term, namely `value'. The question that interests me is the following: What does the articulation of ethics and morality in terms of values mean for ethics and morality as such. Or, to put the question in a more fashionably way: What......As a social scientist of ethics and morality, Luhmann has noticed the ethical wave that has recently swept across the western world, and states that this particular kind of wave seems to have a wavelength of about one hundred years (cf. Luhmann 1989: 9 ff.). Even though the frequency...... and the regularity of such a phenomenon is both hard to verify and, if true, difficult to explain, it seems fair to say that since the Enlightenment, an approaching fin-de-siecle has brought an increased interest in matters concerning morality and ethics.1 The present peak has in public-political discourse and some...

  18. Public Values

    DEFF Research Database (Denmark)

    Beck Jørgensen, Torben; Rutgers, Mark R.

    2015-01-01

    administration is approached in terms of processes guided or restricted by public values and as public value creating: public management and public policy-making are both concerned with establishing, following and realizing public values. To study public values a broad perspective is needed. The article suggest......This article provides the introduction to a symposium on contemporary public values research. It is argued that the contribution to this symposium represent a Public Values Perspective, distinct from other specific lines of research that also use public value as a core concept. Public...... a research agenda for this encompasing kind of public values research. Finally the contributions to the symposium are introduced....

  19. Values Research

    Science.gov (United States)

    2009-10-01

    that individualistic employees in individualistic organizations and collectivistic employees in collectivistic organizations show greater job...with Parsons’ causal assumption, in the nineties values were recognized on top of the cultural control –values control norms which in turn control...determines intention which may end in behavior. 7 Defining Human Values Cross- cultural theories on values emerged in the 80s developed by three main

  20. Synthesis, Antiproliferative, and Multidrug Resistance Reversal Activities of Heterocyclic α,β-Unsaturated Carbonyl Compounds.

    Science.gov (United States)

    Sun, Ju-Feng; Hou, Gui-Ge; Zhao, Feng; Cong, Wei; Li, Hong-Juan; Liu, Wen-Shuai; Wang, Chunhua

    2016-10-01

    A series of heterocyclic α,β-unsaturated carbonyl compounds (1a-1d, 2a-2d, 3a-3d, 4a-3d, and 5a-5d) with 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore were synthesized for the development of anticancer and multidrug resistance reverting agents. The antiproliferative activities were tested against nine human cancer cell lines. Approximately 73% of the IC50 values were below 5 μm, while 35% of these figures were submicromolar, and compounds 3a-3d with 4-trifluoro methyl in the arylidene benzene rings were the most potent, since their IC50 values are between 0.06 and 3.09 μm against all cancer cell lines employed. Meanwhile, their multidrug resistance reversal properties and cellular uptake were further examined. The data displayed that all of these compounds could reverse multidrug resistance, particularly, compounds 3a and 4a demonstrated both potent multidrug resistance reverting properties and strong antiproliferative activities, which can be taken as leading molecules for further research of dual effect agents in tumor chemotherapy. © 2016 John Wiley & Sons A/S.

  1. Default values

    International Nuclear Information System (INIS)

    1987-08-01

    In making calculations for the purposes of radiation protection, numerical values for parameters used in the calculations are selected. In some cases, data directly applicable to the set of conditions for which the calculations are to be made are unavailable. Therefore, the selection of the values for these parameters may be based on more general data available from the literature or other sources. These values may be referred to as 'default values', that is, values used in default of those based on directly applicable data. The following policy will be applied by Atomic Energy Control Board (AECB) staff in reviewing the radiation protection aspects of submissions associated with licensing, in participating with other organizations in the development of codes and standards, and in any other work which relies to some extent on using default values

  2. Deep Value

    DEFF Research Database (Denmark)

    Asness, Clifford S.; Liew, John M.; Pedersen, Lasse Heje

    premium. Following these episodes, the value strategy has (1) high average returns; (2) low market betas, but high betas to a global value factor; (3) deteriorating fundamentals; (4) negative news sentiment; (5) selling pressure; (6) increased limits to arbitrage; and (7) increased arbitrage activity...

  3. Forestland values.

    Science.gov (United States)

    John H. Beuter; Ralph J. Alig

    2004-01-01

    This issue of the journal of Forestry is devoted to articles about forestland values. Viewed broadly, natural resources and humans are our two basic resources. An expression of the importance of land as a foundation for forest ecosystems is forestland value. Our attitudes about land and the forest ecosystems that they support have changed considerably in recent years....

  4. Synthesis, crystal structure determination, biological screening and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases.

    Science.gov (United States)

    Sultana, Nargis; Sarfraz, Muhammad; Tanoli, Saba Tahir; Akram, Muhammad Safwan; Sadiq, Abdul; Rashid, Umer; Tariq, Muhammad Ilyas

    2017-06-01

    Pursuing the strategy of developing potent AChE inhibitors, we attempted to carry out the N 1 -substitution of 2,3-dihydroquinazolin-4(1H)-one core. A set of 32 N-alkylated/benzylated quinazoline derivatives were synthesized, characterized and evaluated for their inhibition against cholinesterases. N-alkylation of the series of the compounds reported previously (N-unsubstituted) resulted in improved activity. All the compounds showed inhibition of both enzymes in the micromolar to submicromolar range. Structure activity relationship (SAR) of the 32 derivatives showed that N-benzylated compounds possess good activity than N-alkylated compounds. N-benzylated compounds 2ad and 2af were found very active with their IC 50 values toward AChE in submicromolar range (0.8µM and 0.6µM respectively). Binding modes of the synthesized compounds were explored by using GOLD (Genetic Optimization for Ligand Docking) suit v5.4.1. Computational predictions of ADMET studies reveal that all the compounds have good pharmacokinetic properties with no AMES toxicity and carcinogenicity. Moreover, all the compounds are predicted to be absorbed in human intestine and also have the ability to cross blood brain barrier. Overall, the synthesized compounds have established a structural foundation for the design of new inhibitors of cholinesterase. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. The Value of Value Sets

    DEFF Research Database (Denmark)

    Sløk-Madsen, Stefan Kirkegaard; Christensen, Jesper

    The world over classrooms in business schools are being taught that corporate values can impact performance. The argument is typically that culture matter more than strategy plans and culture can be influenced and indeed changed by a shared corporate value set. While the claim seems intuitively a...... a unique contribution to the effects of investment in shared company values, and to whether agent rationality can be fundamentally changed by committed organizational efforts....

  6. Value Representations

    DEFF Research Database (Denmark)

    Rasmussen, Majken Kirkegaard; Petersen, Marianne Graves

    2011-01-01

    Stereotypic presumptions about gender affect the design process, both in relation to how users are understood and how products are designed. As a way to decrease the influence of stereotypic presumptions in design process, we propose not to disregard the aspect of gender in the design process......, as the perspective brings valuable insights on different approaches to technology, but instead to view gender through a value lens. Contributing to this perspective, we have developed Value Representations as a design-oriented instrument for staging a reflective dialogue with users. Value Representations...

  7. Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis.

    Science.gov (United States)

    Wang, Qiantao; Edupuganti, Ramakrishna; Tavares, Clint D J; Dalby, Kevin N; Ren, Pengyu

    2015-01-01

    A-484954 is a known eEF2K inhibitor with submicromolar IC50 potency. However, the binding mechanism and the crystal structure of the kinase remains unknown. Here, we employ a homology eEF2K model, docking and alchemical free energy simulations to probe the binding mechanism of eEF2K, and in turn, guide the optimization of potential lead compounds. The inhibitor was docked into the ATP-binding site of a homology model first. Three different binding poses, hypothesis 1, 2, and 3, were obtained and subsequently applied to molecular dynamics (MD) based alchemical free energy simulations. The calculated relative binding free energy of the analogs of A-484954 using the binding pose of hypothesis 1 show a good correlation with the experimental IC50 values, yielding an r (2) coefficient of 0.96 after removing an outlier (compound 5). Calculations using another two poses show little correlation with experimental data, (r (2) of less than 0.5 with or without removing any outliers). Based on hypothesis 1, the calculated relative free energy suggests that bigger cyclic groups, at R1 e.g., cyclobutyl and cyclopentyl promote more favorable binding than smaller groups, such as cyclopropyl and hydrogen. Moreover, this study also demonstrates the ability of the alchemical free energy approach in combination with docking and homology modeling to prioritize compound synthesis. This can be an effective means of facilitating structure-based drug design when crystal structures are not available.

  8. Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β-Amyloid (Aβ) Aggregation.

    Science.gov (United States)

    Tonelli, Michele; Catto, Marco; Tasso, Bruno; Novelli, Federica; Canu, Caterina; Iusco, Giovanna; Pisani, Leonardo; Stradis, Angelo De; Denora, Nunzio; Sparatore, Anna; Boido, Vito; Carotti, Angelo; Sparatore, Fabio

    2015-06-01

    Multitarget therapeutic leads for Alzheimer's disease were designed on the models of compounds capable of maintaining or restoring cell protein homeostasis and of inhibiting β-amyloid (Aβ) oligomerization. Thirty-seven thioxanthen-9-one, xanthen-9-one, naphto- and anthraquinone derivatives were tested for the direct inhibition of Aβ(1-40) aggregation and for the inhibition of electric eel acetylcholinesterase (eeAChE) and horse serum butyrylcholinesterase (hsBChE). These compounds are characterized by basic side chains, mainly quinolizidinylalkyl moieties, linked to various bi- and tri-cyclic (hetero)aromatic systems. With very few exceptions, these compounds displayed inhibitory activity on both AChE and BChE and on the spontaneous aggregation of β-amyloid. In most cases, IC50 values were in the low micromolar and sub-micromolar range, but some compounds even reached nanomolar potency. The time course of amyloid aggregation in the presence of the most active derivative (IC50 =0.84 μM) revealed that these compounds might act as destabilizers of mature fibrils rather than mere inhibitors of fibrillization. Many compounds inhibited one or both cholinesterases and Aβ aggregation with similar potency, a fundamental requisite for the possible development of therapeutics exhibiting a multitarget mechanism of action. The described compounds thus represent interesting leads for the development of multitarget AD therapeutics. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Virtual screening, SAR, and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor.

    Science.gov (United States)

    Ziedan, Noha I; Hamdy, Rania; Cavaliere, Alessandra; Kourti, Malamati; Prencipe, Filippo; Brancale, Andrea; Jones, Arwyn T; Westwell, Andrew D

    2017-07-01

    A new series of oxadiazoles were designed to act as inhibitors of the anti-apoptotic Bcl-2 protein. Virtual screening led to the discovery of new hits that interact with Bcl-2 at the BH3 binding pocket. Further study of the structure-activity relationship of the most active compound of the first series, compound 1, led to the discovery of a novel oxadiazole analogue, compound 16j, that was a more potent small-molecule inhibitor of Bcl-2. 16j had good in vitro inhibitory activity with submicromolar IC 50 values in a metastatic human breast cancer cell line (MDA-MB-231) and a human cervical cancer cell line (HeLa). The antitumour effect of 16j is concomitant with its ability to bind to Bcl-2 protein as shown by an enzyme-linked immunosorbent assay (IC 50  = 4.27 μm). Compound 16j has a great potential to develop into highly active anticancer agent. © 2017 John Wiley & Sons A/S.

  10. Telomerase Inhibition by a New Synthetic Derivative of the Aporphine Alkaloid Boldine

    Directory of Open Access Journals (Sweden)

    Sakineh Kazemi Noureini

    2018-04-01

    Full Text Available Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus, is known to inhibit telomerase at non-toxic concentrations. Cytotoxicity of N-benzylsecoboldine hydrochloride (BSB, a synthetic derivative of boldine, was determined using the MTT method in MCF7 and MDA-MB231 cells. Aliquots of cell lysates were incubated with various concentrations of BSB in qTRAP (quantitative telomere repeat amplification protocol-ligand experiments before substrate elongation by telomerase or amplification by hot-start Taq polymerase. The crystal structure of TERT, the catalytic subunit of telomerase from Tribolium castaneum, was used for docking and molecular dynamics analysis. The qTRAP-ligand data gave an IC50 value of about 0.17 ± 0.1 µM for BSB, roughly 400 times stronger than boldine, while the LD50 in the cytotoxicity assays were 12.5 and 21.88 µM, respectively, in cells treated for 48 h. Although both compounds interacted well with the active site, MD analysis suggests a second binding site with which BSB interacts via two hydrogen bonds, much more strongly than boldine. Theoretical analyses also evaluated the IC50 for BSB as submicromolar. BSB, with greater hydrophobicity and flexibility than boldine, represents a promising structure to inhibit telomerase at non-toxic concentrations.

  11. Unravelling Value

    DEFF Research Database (Denmark)

    Walsh, Matthew

    Paper presented in the symposium “What’s It All Worth? Material Possessions and Value in Past Societies” at 22nd Annual Meeting of the European Association of Archaeologists, Vilnius, Lithuania.......Paper presented in the symposium “What’s It All Worth? Material Possessions and Value in Past Societies” at 22nd Annual Meeting of the European Association of Archaeologists, Vilnius, Lithuania....

  12. Public Value: rethinking value creation

    OpenAIRE

    Meynhardt, Timo; Gomez, Peter; Strathoff, Pepe; Hermann, Carolin

    2014-01-01

    Managers might refute public criticism of their business as an attitude of taking everything for granted in a saturated society, but ignoring Public Value aspects can threaten the success of new products and even the survival of entire firms.

  13. Add Value

    DEFF Research Database (Denmark)

    Kobbelgaard, Cecilie Elisabeth

    2016-01-01

    "Add Value – kend din kunde" er et brætspil, som giver både offentlige og private virksomheder unikke muligheder for at forbedre deres service overfor kunderne. Spillet giver, på en alternativ og handlingsorienteret måde, mulighed for at blive skarpere på kundeoplevelsen – hvor er der værdi...... at hente, og hvor kan der spares på tid og ressourcer? Dette samtidig med, at kunderne får den oplevelse og service, de forventer. Når I spiller "Add Value – kend din kunde" sættes der fokus på Jeres kundeservice ud fra kundens perspektiv, og det er i alle Jeres kontaktflader med kunden. Lige fra kunden...

  14. Conservation Value

    OpenAIRE

    Tisdell, Clement A.

    2010-01-01

    This paper outlines the significance of the concept of conservation value and discusses ways in which it is determined paying attention to views stemming from utilitarian ethics and from deontological ethics. The importance of user costs in relation to economic decisions about the conservation and use of natural resources is emphasised. Particular attention is given to competing views about the importance of conserving natural resources in order to achieve economic sustainability. This then l...

  15. Valuing hope.

    Science.gov (United States)

    McMillan, John; Walker, Simon; Hope, Tony

    2014-01-01

    This article argues that hope is of value in clinical ethics and that it can be important for clinicians to be sensitive to both the risks of false hope and the importance of retaining hope. However, this sensitivity requires an understanding of the complexity of hope and how it bears on different aspects of a well-functioning doctor-patient relationship. We discuss hopefulness and distinguish it, from three different kinds of hope, or 'hopes for', and then relate these distinctions back to differing accounts of autonomy. This analysis matters because it shows how an overly narrow view of the ethical obligations of a clinician to their patient, and autonomy, might lead to scenarios where patients regret the choices they make.

  16. Fair Value or Market Value?

    Directory of Open Access Journals (Sweden)

    Bogdan Cosmin Gomoi

    2014-12-01

    Full Text Available When taking into consideration the issue of defining the “fair value” concept, those less experimented in the area often fall in the “price trap”, which is considered as an equivalent of the fair value of financial structures. This valuation basis appears as a consequence of the trial to provide an “accurate image” by the financial statements and, also, as an opportunity for the premises offered by the activity continuing principle. The specialized literature generates ample controversies regarding the “fair value” concept and the “market value” concept. The paper aims to debate this issue, taking into account various opinions.

  17. Valuing vaccination.

    Science.gov (United States)

    Bärnighausen, Till; Bloom, David E; Cafiero-Fonseca, Elizabeth T; O'Brien, Jennifer Carroll

    2014-08-26

    Vaccination has led to remarkable health gains over the last century. However, large coverage gaps remain, which will require significant financial resources and political will to address. In recent years, a compelling line of inquiry has established the economic benefits of health, at both the individual and aggregate levels. Most existing economic evaluations of particular health interventions fail to account for this new research, leading to potentially sizable undervaluation of those interventions. In line with this new research, we set forth a framework for conceptualizing the full benefits of vaccination, including avoided medical care costs, outcome-related productivity gains, behavior-related productivity gains, community health externalities, community economic externalities, and the value of risk reduction and pure health gains. We also review literature highlighting the magnitude of these sources of benefit for different vaccinations. Finally, we outline the steps that need to be taken to implement a broad-approach economic evaluation and discuss the implications of this work for research, policy, and resource allocation for vaccine development and delivery.

  18. Microbial Communities in Contaminated Sediments, Associated with Bioremediation of Uranium to Submicromolar Levels▿

    Science.gov (United States)

    Cardenas, Erick; Wu, Wei-Min; Leigh, Mary Beth; Carley, Jack; Carroll, Sue; Gentry, Terry; Luo, Jian; Watson, David; Gu, Baohua; Ginder-Vogel, Matthew; Kitanidis, Peter K.; Jardine, Philip M.; Zhou, Jizhong; Criddle, Craig S.; Marsh, Terence L.; Tiedje, James M.

    2008-01-01

    Microbial enumeration, 16S rRNA gene clone libraries, and chemical analysis were used to evaluate the in situ biological reduction and immobilization of uranium(VI) in a long-term experiment (more than 2 years) conducted at a highly uranium-contaminated site (up to 60 mg/liter and 800 mg/kg solids) of the U.S. Department of Energy in Oak Ridge, TN. Bioreduction was achieved by conditioning groundwater above ground and then stimulating growth of denitrifying, Fe(III)-reducing, and sulfate-reducing bacteria in situ through weekly injection of ethanol into the subsurface. After nearly 2 years of intermittent injection of ethanol, aqueous U levels fell below the U.S. Environmental Protection Agency maximum contaminant level for drinking water and groundwater (reducers were detected, including Desulfovibrio, Geobacter, Anaeromyxobacter, Desulfosporosinus, and Acidovorax spp. The predominant sulfate-reducing bacterial species were Desulfovibrio spp., while the iron reducers were represented by Ferribacterium spp. and Geothrix spp. Diversity-based clustering revealed differences between treated and untreated zones and also within samples of the treated area. Spatial differences in community structure within the treatment zone were likely related to the hydraulic pathway and to electron donor metabolism during biostimulation. PMID:18456853

  19. In Situ Bioreduction of Uranium (VI) to Submicromolar Levels and Reoxidation by Dissolved Oxygen

    International Nuclear Information System (INIS)

    Wu, Weimin; Carley, Jack M.; Luo, Jian; Ginder-Vogel, Matthew A.; Cardenas, Erick; Leigh, Mary Beth; Hwang, Chaichi; Kelly, Shelly D.; Ruan, Chuanmin; Wu, Liyou; Van Nostrand, Joy; Gentry, Terry J.; Lowe, Kenneth Alan; Mehlhorn, Tonia L.; Carroll, Sue L.; Luo, Wensui; Fields, Matthew Wayne; Gu, Baohua; Watson, David B.; Kemner, Kenneth M.; Marsh, Terence; Tiedje, James; Zhou, Jizhong; Fendorf, Scott; Kitanidis, Peter K.; Jardine, Philip M.; Criddle, Craig

    2007-01-01

    Groundwater within Area 3 of the U.S. Department of Energy (DOE) Environmental Remediation Sciences Program (ERSP) Field Research Center at Oak Ridge, TN (ORFRC) contains up to 135 (micro)M uranium as U(VI). Through a series of experiments at a pilot scale test facility, we explored the lower limits of groundwater U(VI) that can be achieved by in-situ biostimulation and the effects of dissolved oxygen on immobilized uranium. Weekly 2 day additions of ethanol over a 2-year period stimulated growth of denitrifying, Fe(III)-reducing, and sulfate-reducing bacteria, and immobilization of uranium as U(IV), with dissolved uranium concentrations decreasing to low levels. Following sulfite addition to remove dissolved oxygen, aqueous U(VI) concentrations fell below the U.S. Environmental Protection Agency maximum contaminant limit (MCL) for drinking water ( -1 or 0.126 (micro)M). Under anaerobic conditions, these low concentrations were stable, even in the absence of added ethanol. However, when sulfite additions stopped, and dissolved oxygen (4.0-5.5 mg L -1 ) entered the injection well, spatially variable changes in aqueous U(VI) occurred over a 60 day period, with concentrations increasing rapidly from <0.13 to 2.0 (micro)M at a multilevel sampling (MLS) well located close to the injection well, but changing little at an MLS well located further away. Resumption of ethanol addition restored reduction of Fe(III), sulfate, and U(VI) within 36 h. After 2 years of ethanol addition, X-ray absorption near-edge structure spectroscopy (XANES) analyses indicated that U(IV) comprised 60-80% of the total uranium in sediment samples. At the completion of the project (day 1260), U concentrations in MLS wells were less than 0.1 (micro)M. The microbial community at MLS wells with low U(VI) contained bacteria that are known to reduce uranium, including Desulfovibrio spp. and Geobacter spp., in both sediment and groundwater. The dominant Fe(III)-reducing species were Geothrix spp

  20. Novel cytokinin derivatives do not show negative effects on root growth and proliferation in submicromolar range.

    Directory of Open Access Journals (Sweden)

    Kateřina Podlešáková

    Full Text Available BACKGROUND: When applied to a nutrition solution or agar media, the non-substituted aromatic cytokinins caused thickening and shortening of the primary root, had an inhibitory effect on lateral root branching, and even showed some negative effects on development of the aerial part at as low as a 10 nanomolar concentration. Novel analogues of aromatic cytokinins ranking among topolins substituted on N9-atom of adenine by tetrahydropyranyl or 4-chlorobutyl group have been prepared and tested in standardized cytokinin bioassays [1]. Those showing comparable activities with N(6-benzylaminopurine were further tested in planta. METHODOLOGY/PRINCIPAL FINDINGS: The main aim of the study was to explain molecular mechanism of function of novel cytokinin derivatives on plant development. Precise quantification of cytokinin content and profiling of genes involved in cytokinin metabolism and perception in treated plants revealed several aspects of different action of m-methoxytopolin base and its substituted derivative on plant development. In contrast to standard cytokinins, N9- tetrahydropyranyl derivative of m-topolin and its methoxy-counterpart showed the negative effects on root development only at three orders of magnitude higher concentrations. Moreover, the methoxy-derivative demonstrates a positive effect on lateral root branching and leaf emerging in a nanomolar range of concentrations, in comparison with untreated plants. CONCLUSIONS/SIGNIFICANCE: Tetrahydropyranyl substitution at N9-position of cytokinin purine ring significantly enhances acropetal transport of a given cytokinins. Together with the methoxy-substitution, impedes accumulation of non-active cytokinin glucoside forms in roots, allows gradual release of the active base, and has a significant effect on the distribution and amount of endogenous isoprenoid cytokinins in different plant tissues. The utilization of novel aromatic cytokinin derivatives can distinctively improve expected hormonal effects in plant propagation techniques in the future.

  1. Determination of respiration rates in water with sub-micromolar oxygen concentrations

    Directory of Open Access Journals (Sweden)

    Emilio Garcia-Robledo

    2016-11-01

    Full Text Available It is crucial for our study and understanding of element transformations in low-oxygen waters that we are able to reproduce the in situ conditions during laboratory incubations to an extent that does not result in unacceptable artefacts. In this study we have explored how experimental conditions affect measured rates of O2 consumption in low-O2 waters from the anoxic basin of Golfo Dulce (Costa Rica and oceanic waters off Chile-Peru. High-sensitivity optode dots placed within all-glass incubation containers allowed for high resolution O2 concentration measurements in the nanomolar and low µmolar range and thus also for the determination of rates of oxygen consumption by microbial communities. Consumption rates increased dramatically (from 3 and up to 60 times by prolonged incubations, and started to increase after 4-5 hours in surface waters and after 10-15 h in water from below the upper mixed layer. Estimated maximum growth rates during the incubations suggest the growth of opportunistic microorganism with doubling times as low as 2.8 and 4.6 h for the coastal waters of Golfo Dulce (Costa Rica and oceanic waters off Chile and Peru, respectively. Deoxygenation by inert gas bubbling led to increases in subsequently determined rates, possibly by liberation of organics from lysis of sensitive organisms, particle or aggregate alterations or other processes mediated by the strong turbulence. Stirring of the water during the incubation led to an about 50% increase in samples previously deoxygenated by bubbling, but had no effect in untreated samples. Our data indicate that data for microbial activity obtained by short incubations of minimally manipulated water are most reliable, but deoxygenation is a prerequisite for many laboratory experiments, such as determination of denitrification rates, as O2 contamination by sampling is practically impossible to avoid.

  2. Synthesis and antiproliferative activity of a cyclic analog of dolastatin 10.

    Science.gov (United States)

    Poncet, J; Hortala, L; Busquet, M; Guéritte-Voegelein, F; Thoret, S; Pierré, A; Atassi, G; Jouin, P

    1998-10-20

    A cyclic analog of the natural antiproliferative compound dolastatin 10 was synthesized by introducing an ester link between the N- and C-terminal residues which were modified accordingly. The final macrolactonization was performed by using isopropenyl chloroformate and DMAP as reagents. This analog exhibits submicromolar antiproliferative activity against the L1210 and HT29 cell lines and inhibits in vitro tubulin polymerization (IC50, 39 microM).

  3. Synthesis of 4-Methoxybenzoylhydrazones and Evaluation of Their Antiglycation Activity

    Directory of Open Access Journals (Sweden)

    Muhammad Taha

    2014-01-01

    Full Text Available A series of 4-methoxybenzoylhydrazones 1–30 was synthesized and the structures of the synthetic derivatives elucidated by spectroscopic methods. The compounds showed a varying degree of antiglycation activity, with IC50 values ranging between 216.52 and 748.71 µM, when compared to a rutin standard (IC50 = 294.46 ± 1.50 µM. Compounds 1 (IC50 = 216.52 ± 4.2 µM, 3 (IC50 = 289.58 ± 2.64 µM, 6 (IC50 = 227.75 ± 0.53 µM, 7 (IC50 = 242.53 ± 6.1 and 11 (IC50 = 287.79 ± 1.59 all showed more activity that the standard, and these compounds have the potential to serve as possible leads for drugs to inhibit protein glycation in diabetic patients. A preliminary SAR study was performed.

  4. Novel zinc(II)phthalocyanines bearing azo-containing schiff base: Determination of pKa values, absorption, emission, enzyme inhibition and photochemical properties

    Science.gov (United States)

    Kantar, Cihan; Mavi, Vildan; Baltaş, Nimet; İslamoğlu, Fatih; Şaşmaz, Selami

    2016-10-01

    Azo-containing schiff bases are well known and there are many studies about their various properties in literature. However, phthalocyanines bearing azo-containing schiff bases, their spectral, analytical and biological properties are unknown. Therefore, new zinc (II) phthalocyanines bearing azo-containing schiff base were synthesized and investigated to determine pKa values, absorption, emission, enzyme inhibition and photochemical properties. Emission spectra were reported and large Stokes shift values were determined for all compounds, indicating that all molecules exhibit excited state intramolecular proton transfer. These phthalocyanines were the first examples of phthalocyanine showing excited state intramolecular proton transfer. Singlet oxygen quantum yields of zinc (II) phthalocyanines were determined. pKa values and indicator properties of all compounds were investigated by potentiometry. All compounds were assayed for inhibitory activity against bovine milk xanthine oxidase and acetylcholinesterase enzyme in vitro. Compound 2 showed the high inhibitory effect against xanthine oxidase (IC50 = 0.24 ± 0.01 μM). However, phthalocyanine compounds did not show enzyme inhibitor behavior.

  5. Use value, exchange value, and resource scarcity

    International Nuclear Information System (INIS)

    Stern, D.I.

    1999-01-01

    The literature on natural resource scarcity indicators is reviewed. Scarcity indicators can be classified by what is being measured: value of the resource stock or value of extracted resource commodities; whose value is considered: social vs. private scarcity; and by the mode of valuation considered: exchange value and use value. Prices and rents are common measures of exchange value or indicators of ''exchange scarcity'' and unit costs can be seen as use value indicators or indicators of u se scarcity . The major aim of this paper is to demonstrate the links between productivity indicators such as unit costs and the classical concept of use value. The two classes of indicator relate to John Commons' discussions of scarcity and efficiency, and a marginal vs. a non-marginal approach to value and scarcity. The classical use value concept also has wider relevance for issues of valuation in energy, resource, and environmental policy. (author)

  6. The influence of imipramine and trazodone on platelet [3H]serotonin uptake in depressed patients: changes following treatment

    International Nuclear Information System (INIS)

    Katasonow, A.B.; Brusow, O.S.; Beljaew, B.S.; Slobina, G.P.; Faktor, M.I.; Larionowa, T.B.; Trunte, K.; Lidemann, R.R.

    1989-01-01

    The inhibitory potencies of imipramine (IC 50 values for IMI) and trazodone (IC 50 values for TRA) on platelet [ 3 H]serotonin uptake were measured in depressed patients. The IC 50 values for IMI in patients was shown to be higher (P 50 values for TRA in patients were lower (P 3 H]imipramine binding sites. Drug treatment led to the normalization of the IC 50 values for IMI and to the partial increase of the IC 50 values for TRA. There was a negative correlation of IC 50 values for TRA and severity of depressive symptoms evaluated by the Hamilton Depression Rating Scale. The results support the hypothesis that the mechanisms of the regulation of [ 3 H]serotonin uptake sensitivity to IMI and TRA in patients are different. (author)

  7. 6-Nitrobenzimidazole derivatives: potential phosphodiesterase inhibitors: synthesis and structure-activity relationship.

    Science.gov (United States)

    Khan, K M; Shah, Zarbad; Ahmad, V U; Ambreen, N; Khan, M; Taha, M; Rahim, F; Noreen, S; Perveen, S; Choudhary, M I; Voelter, W

    2012-02-15

    6-Nitrobenzimidazole derivatives (1-30) synthesized and their phosphodiesterase inhibitory activities determined. Out of thirty tested compounds, ten showed a varying degrees of phosphodiesterase inhibition with IC(50) values between 1.5±0.043 and 294.0±16.7 μM. Compounds 30 (IC(50)=1.5±0.043 μM), 1 (IC(50)=2.4±0.049 μM), 11 (IC(50)=5.7±0.113 μM), 13 (IC(50)=6.4±0.148 μM), 14 (IC(50)=10.5±0.51 μM), 9 (IC(50)=11.49±0.08 μM), 3 (IC(50)=63.1±1.48 μM), 10 (IC(50)=120.0±4.47 μM), and 6 (IC(50)=153.2±5.6 μM) showed excellent phosphodiesterase inhibitory activity, much superior to the standard EDTA (IC(50)=274±0.007 μM), and thus are potential molecules for the development of a new class of phosphodiesterase inhibitors. A structure-activity relationship is evaluated. All compounds are characterized by spectroscopic parameters. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. In vitro and in vivo activity of melflufen (J1)in lymphoma

    International Nuclear Information System (INIS)

    Delforoush, Maryam; Strese, Sara; Wickström, Malin; Larsson, Rolf; Enblad, Gunilla; Gullbo, Joachim

    2016-01-01

    Melphalan has been used in the treatment of various hematologic malignancies for almost 60 years. Today it is part of standard therapy for multiple myeloma and also as part of myeloablative regimens in association with autologous allogenic stem cell transplantation. Melflufen (melphalan flufenamide ethyl ester, previously called J1) is an optimized derivative of melphalan providing targeted delivery of active metabolites to cells expressing aminopeptidases. The activity of melflufen has compared favorably with that of melphalan in a series of in vitro and in vivo experiments performed preferentially on different solid tumor models and multiple myeloma. Melflufen is currently being evaluated in a clinical phase I/II trial in relapsed or relapsed and refractory multiple myeloma. Cytotoxicity of melflufen was assayed in lymphoma cell lines and in primary tumor cells with the Fluorometric Microculture Cytotoxicity Assay and cell cycle analyses was performed in two of the cell lines. Melflufen was also investigated in a xenograft model with subcutaneous lymphoma cells inoculated in mice. Melflufen showed activity with cytotoxic IC 50 -values in the submicromolar range (0.011-0.92 μM) in the cell lines, corresponding to a mean of 49-fold superiority (p < 0.001) in potency vs. melphalan. In the primary cultures melflufen yielded slightly lower IC 50 -values (2.7 nM to 0.55 μM) and an increased ratio vs. melphalan (range 13–455, average 108, p < 0.001). Treated cell lines exhibited a clear accumulation in the G2/M-phase of the cell cycle. Melflufen also showed significant activity and no, or minimal side effects in the xenografted animals. This study confirms previous reports of a targeting related potency superiority of melflufen compared to that of melphalan. Melflufen was active in cell lines and primary cultures of lymphoma cells, as well as in a xenograft model in mice and appears to be a candidate for further evaluation in the treatment of this group of malignant

  9. Projects as value constellations

    DEFF Research Database (Denmark)

    Laursen, Markus

    Creating value has been outlined as very central to projects applying the organizational perspective to projects. It has been suggested that value is created in value constellations or project networks, where actors work together to create value. However, research on the value creation process...... in value constellations is scarce, and through an exploratory study of two project networks in a cultural setting we investigate how value is created in value constellations. We outline how each project may be a distinct type of value constellation, one project creates value for the partners of the network...... as a consortium, and the project creates value primarily for others as a facilitator....

  10. Value-based pricing

    OpenAIRE

    Netseva-Porcheva Tatyana

    2010-01-01

    The main aim of the paper is to present the value-based pricing. Therefore, the comparison between two approaches of pricing is made - cost-based pricing and value-based pricing. The 'Price sensitively meter' is presented. The other topic of the paper is the perceived value - meaning of the perceived value, the components of perceived value, the determination of perceived value and the increasing of perceived value. In addition, the best company strategies in matrix 'value-cost' are outlined. .

  11. Indigenous environmental values as human values

    Directory of Open Access Journals (Sweden)

    Monica Gratani

    2016-12-01

    Full Text Available The claim that in natural resource management (NRM a change from anthropocentric values and ethics to eco-centric ones is necessary to achieve sustainability leads to the search for eco-centric models of relationship with the environment. Indigenous cultures can provide such models; hence, there is the need for multicultural societies to further include their values in NRM. In this article, we investigate the environmental values placed on a freshwater environment of the Wet Tropics by a community of indigenous Australians. We discuss their environmental values as human values, and so as beliefs that guide communities’ understanding of how the natural world should be viewed and treated by humans. This perspective represents a step forward in our understanding of indigenous environmental values, and a way to overcome the paradigm of indigenous values as valued biophysical attributes of the environment or processes happening in landscapes. Our results show that the participant community holds biospheric values. Restoring these values in the NRM of the Wet Tropics could contribute to sustainability and environmental justice in the area.

  12. Design and synthesis of thienopyrimidine urea derivatives with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7.

    Science.gov (United States)

    Abdelhaleem, Eman F; Abdelhameid, Mohammed K; Kassab, Asmaa E; Kandeel, Manal M

    2018-01-01

    A series of novel tetrahydrobenzothieno[2,3-d]pyrimidine urea derivatives was synthesized according to fragment-based design strategy. They were evaluated for their anticancer activity against MCF-7 cell line. Three compounds 9c, 9d and 11b showed 1.5-1.03 folds more potent anticancer activity than doxorubicin. In this study, a promising multi-sited enzyme small molecule inhibitor 9c, which showed the most potent anti-proliferative activity, was identified. The anti-proliferative activity of this compound appears to correlate well with its ability to inhibit topoisomerase II (IC 50  = 9.29 μM). Moreover, compound 9c showed excellent VEGFR-2 inhibitory activity, at the sub-micromolar level with IC 50 value 0.2 μM, which is 2.1 folds more potent than sorafenib. Moreover, activation of damage response pathway of the DNA leads to cell cycle arrest at G2/M phase, accumulation of cells in pre-G1 phase and annexin-V and propidium iodide staining, indicating that cell death proceeds through an apoptotic mechanism. Compound 9c showed potent pro-apoptotic effect through induction of the intrinsic mitochondrial pathway of apoptosis. This mechanistic pathway was confirmed by a significant increase in the expression of the tumor suppressor gene p53, elevation in Bax/BCL-2 ratio and a significant increase in the level of active caspase-3. Quantitative structure-activity relationship (QSAR) studies delivered equations of five 3D descriptors with R 2  = 0.814. This QSAR model provides an effective technique for understanding the observed antitumor properties and thus could be adopted for developing effective lead structures. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  13. KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library.

    Science.gov (United States)

    González-Bacerio, Jorge; Maluf, Sarah El Chamy; Méndez, Yanira; Pascual, Isel; Florent, Isabelle; Melo, Pollyana M S; Budu, Alexandre; Ferreira, Juliana C; Moreno, Ernesto; Carmona, Adriana K; Rivera, Daniel G; Alonso Del Rivero, Maday; Gazarini, Marcos L

    2017-09-01

    Malaria is a global human parasitic disease mainly caused by the protozoon Plasmodium falciparum. Increased parasite resistance to current drugs determines the relevance of finding new treatments against new targets. A novel target is the M1 alanyl-aminopeptidase from P. falciparum (PfA-M1), which is essential for parasite development in human erythrocytes and is inhibited by the pseudo-peptide bestatin. In this work, we used a combinatorial multicomponent approach to produce a library of peptidomimetics and screened it for the inhibition of recombinant PfA-M1 (rPfA-M1) and the in vitro growth of P. falciparum erythrocytic stages (3D7 and FcB1 strains). Dose-response studies with selected compounds allowed identifying the bestatin-based peptidomimetic KBE009 as a submicromolar rPfA-M1 inhibitor (K i =0.4μM) and an in vitro antimalarial compound as potent as bestatin (IC 50 =18μM; without promoting erythrocyte lysis). At therapeutic-relevant concentrations, KBE009 is selective for rPfA-M1 over porcine APN (a model of these enzymes from mammals), and is not cytotoxic against HUVEC cells. Docking simulations indicate that this compound binds PfA-M1 without Zn 2+ coordination, establishing mainly hydrophobic interactions and showing a remarkable shape complementarity with the active site of the enzyme. Moreover, KBE009 inhibits the M1-type aminopeptidase activity (Ala-7-amido-4-methylcoumarin substrate) in isolated live parasites with a potency similar to that of the antimalarial activity (IC 50 =82μM), strongly suggesting that the antimalarial effect is directly related to the inhibition of the endogenous PfA-M1. These results support the value of this multicomponent strategy to identify PfA-M1 inhibitors, and make KBE009 a promising hit for drug development against malaria. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Maslow and Values Education

    Science.gov (United States)

    Farmer, Rodney

    1978-01-01

    Identifies major value bases which have been used to teach values in the classroom and outlines a values education program which stresses teaching about values without indoctrination. Based upon the hierarchy of human needs developed by psychologist Abraham Maslow, the program is based upon universal values, basic human needs, and recognition of…

  15. The Global Value Chain

    DEFF Research Database (Denmark)

    Sørensen, Olav Jull

    The conference paper aims to develop the global value chain concept by including corporate internal value adding activities and competition to the basic framework in order to turn the global value chain into a strategic management tool......The conference paper aims to develop the global value chain concept by including corporate internal value adding activities and competition to the basic framework in order to turn the global value chain into a strategic management tool...

  16. Value-based pricing

    Directory of Open Access Journals (Sweden)

    Netseva-Porcheva Tatyana

    2010-01-01

    Full Text Available The main aim of the paper is to present the value-based pricing. Therefore, the comparison between two approaches of pricing is made - cost-based pricing and value-based pricing. The 'Price sensitively meter' is presented. The other topic of the paper is the perceived value - meaning of the perceived value, the components of perceived value, the determination of perceived value and the increasing of perceived value. In addition, the best company strategies in matrix 'value-cost' are outlined. .

  17. Valuing future citizens' values regarding risk

    International Nuclear Information System (INIS)

    Fleming, Patricia

    2006-01-01

    Valuing present citizen's values regarding the risks they face is an important aspect of risk assessment and risk acceptability. Conferences like VALDOR are held for this reason. Governments like Sweden have national referendums on various risk-prone enterprises. The results of these referendums can determine the future of these programs. In the United States, when guidelines are set for determining acceptable levels of risk, the relevant federal agencies are often required to provide a comment period regarding proposed guidelines in order to ascertain the judgments, including the weights place on certain values, of individual members of society as well as stakeholder groups. After the comment period ends, the agency decides on the acceptable level of risk, taking into account the comments from present citizens. Do we also have a duty to value the not-yet-existing values of future citizens, especially if the risks created by the activities of present citizens extend into the future to citizens not yet living? If so, are there any circumstances which entitle us to de-value those not-yet-existing values. In this paper, I ground my discussion of the question of valuing future citizens' values in one of the areas of focus of the VALDOR conference: nuclear waste management and specifically the question facing the United States' program regarding an acceptable dose standard associated with the release of radioactivity into the biosphere from an underground repository. The underlying conference theme to which this discussion may be attached is community environmental justice as it applies to future citizens. I focus on the role that uncertainty plays is providing justice between present and future citizens

  18. Valuing future citizens' values regarding risk

    Energy Technology Data Exchange (ETDEWEB)

    Fleming, Patricia [Creighton Univ., Omaha (United States). College of Arts and Sciences/Philosophy

    2006-09-15

    Valuing present citizen's values regarding the risks they face is an important aspect of risk assessment and risk acceptability. Conferences like VALDOR are held for this reason. Governments like Sweden have national referendums on various risk-prone enterprises. The results of these referendums can determine the future of these programs. In the United States, when guidelines are set for determining acceptable levels of risk, the relevant federal agencies are often required to provide a comment period regarding proposed guidelines in order to ascertain the judgments, including the weights place on certain values, of individual members of society as well as stakeholder groups. After the comment period ends, the agency decides on the acceptable level of risk, taking into account the comments from present citizens. Do we also have a duty to value the not-yet-existing values of future citizens, especially if the risks created by the activities of present citizens extend into the future to citizens not yet living? If so, are there any circumstances which entitle us to de-value those not-yet-existing values. In this paper, I ground my discussion of the question of valuing future citizens' values in one of the areas of focus of the VALDOR conference: nuclear waste management and specifically the question facing the United States' program regarding an acceptable dose standard associated with the release of radioactivity into the biosphere from an underground repository. The underlying conference theme to which this discussion may be attached is community environmental justice as it applies to future citizens. I focus on the role that uncertainty plays is providing justice between present and future citizens.

  19. Value representations: a value based dialogue tool

    DEFF Research Database (Denmark)

    Petersen, Marianne Graves; Rasmussen, Majken Kirkegaard

    2011-01-01

    Stereotypic presumptions about gender affect the design process, both in relation to how users are understood and how products are designed. As a way to decrease the influence of stereotypic presumptions in design process, we propose not to disregard the aspect of gender in the design process......, as the perspective brings valuable insights on different approaches to technology, but instead to view gender through a value lens. Contributing to this perspective, we have developed Value Representations as a design-oriented instrument for staging a reflective dialogue with users. Value Representations...

  20. Human rights values or cultural values? Pursuing values to maintain ...

    African Journals Online (AJOL)

    We argue that positive discipline in multicultural school environments needs to be based in part on human rights values that are neither solely universally interpreted nor particularistically interpreted. We report on the data generated at a research workshop held as the final dissemination process of a four-year international ...

  1. Hunters' motivations and values:

    DEFF Research Database (Denmark)

    Radder, Laetitia; Bech-Larsen, Tino

    2008-01-01

    This article examines the values and motivations of South African biltong hunters. A hierarchical value map of associations between attributes, consequences and values resulted from laddering interviews with 34 hunters. The Means-End Chain approach proved useful in identifying: (a) personal value...

  2. Five Values of Giftedness

    Science.gov (United States)

    Besjes-de Bock, Karin M.; de Ruyter, Doret J.

    2011-01-01

    This article describes five values attributed to giftedness. The ascription of values to this phenomenon resembles values attached to gifts in gift-giving processes. Whereas gift-giving often includes expectations of reciprocity, each gift possesses a numerical, utility, social, personal, and intrinsic value. Developmental models of giftedness and…

  3. Equivalence, commensurability, value

    DEFF Research Database (Denmark)

    Albertsen, Niels

    2017-01-01

    Deriving value in Capital Marx uses three commensurability arguments (CA1-3). CA1 establishes equivalence in exchange as exchangeability with the same third commodity. CA2 establishes value as common denominator in commodities: embodied abstract labour. CA3 establishes value substance...... as commonality of labour: physiological labour. Tensions between these logics have permeated Marxist interpretations of value. Some have supported value as embodied labour (CA2, 3), others a monetary theory of value and value as ‘pure’ societal abstraction (ultimately CA1). They all are grounded in Marx....

  4. Political Values or the Value of Politics

    Directory of Open Access Journals (Sweden)

    Simoska, Emilija

    2016-04-01

    Full Text Available This essay was motivated by the gap between proclaimed democratic principles and the perceptions of politics which are exhibited by the citizens in transitional countries -more specifically in the Republic of Macedonia. It is based on research data collected in the past few decades, which illustrate that, in their political actions, the citizens are highly motivated by personal benefits and profits, rather than by their internalized values and ideologies. Non-democratic, authoritarian values prevail, while politics is perceived as a value itself, in the most materialistic meaning of the word. It creates a suitable milieu for growth of corruption, nepotism and clientelism. The authors conclude that such a circulus vitsiosus is a corner stone of the Macedonian political regime, and an enormous obstacle for the advancement of the participative, democratic political culture in reality, in spite of its formal acceptance.

  5. Tracing Public Values Change

    DEFF Research Database (Denmark)

    Beck Jørgensen, Torben; Rutgers, Mark R.

    2014-01-01

    Long term changes in public values are not easily detected. One important reason is the limited availability of reliable empirical data. Job advertisements allow us to go back in history for some decades and job ads may present us with the values that are supposed to guide civil servant behaviour...... in several directions; b) job ads develop into platforms for organizational branding with an emphasis on HR-related values although national logos enter the scene (the Danish royal crown, the Dutch national emblem); c) New Public Management values do not crowd out other values, rather value intensity...

  6. Valuing values: A history of wilderness economics

    Science.gov (United States)

    J. M. Bowker; H. K. Cordell; N. C. Poudyal

    2014-01-01

    Prior to the U.S. Wilderness Act of 1964, economics as a science was hardly considered applicable to the types of human values set forth in this pathbreaking legislation. Economics was largely confined to the purchasing and labor decisions of households and firms as well the functioning of markets and economies. However, around this time, John Krutilla (1967) in his...

  7. Value of care - National

    Data.gov (United States)

    U.S. Department of Health & Human Services — Value of care displays – national data. This data set includes national-level data for the value of care displays associated with an episode of care for heart...

  8. Value Set Authority Center

    Data.gov (United States)

    U.S. Department of Health & Human Services — The VSAC provides downloadable access to all official versions of vocabulary value sets contained in the 2014 Clinical Quality Measures (CQMs). Each value set...

  9. Fair market value

    International Nuclear Information System (INIS)

    Williams, J.

    1991-01-01

    This paper presents an examination of fair market value concepts as they pertain to producing petroleum properties. conventional petroleum economic theories of fair market value are examined in light of recent work on the market value of long-life reserves. Their work is expanded to show that sellers rely on comparable sales data for estimating FMV. Both results are used to suggest that current practices over-emphasize the discounted cash flow approach to estimating fair market value

  10. The Value of Accounting

    OpenAIRE

    Peek, Erik

    2011-01-01

    textabstractFair value estimates of debt and equity securities play an increasingly important role in the economy. For example, International Financial Reporting Standards require companies to report many of their investments at fair value on the balance sheet or to use fair values in goodwill impairment tests. Further, the funding status of pension plans is typically assessed as the difference between the fair values of pension plan assets and pension plan commitments. In many of these situa...

  11. ATLAS OF EUROPEAN VALUES

    NARCIS (Netherlands)

    M Ed Uwe Krause

    2008-01-01

    Uwe Krause: Atlas of Eurpean Values De Atlas of European Values is een samenwerkingsproject met bijbehorende website van de Universiteit van Tilburg en Fontys Lerarenopleiding in Tilburg, waarbij de wetenschappelijke data van de European Values Study (EVS) voor het onderwijs toegankelijk worden

  12. Value Conditionality of Identity

    Directory of Open Access Journals (Sweden)

    M M Yusupov

    2013-12-01

    Full Text Available The article considers theoretical approaches to the study of values and identity, and reveals the role of values in the formation of the ethnic, regional and Russian identity on the example of Chechnya and the North Caucasus, with the sociological indicators characterizing value orientations and self-identification.

  13. Core Values | NREL

    Science.gov (United States)

    Core Values Core Values NREL's core values are rooted in a safe and supportive work environment guide our everyday actions and efforts: Safe and supportive work environment Respect for the rights physical and social environment Integrity Maintain the highest standard of ethics, honesty, and integrity

  14. Hierarchical Classification of Values

    Science.gov (United States)

    Ergen, Gürkan

    2015-01-01

    Values are of utmost importance for the creation, development and sustainability of a life worthy of human dignity. However, because even superficial views of values are regarded as values themselves, they have become relative and become degenerated; therefore, they have lost the properties--potentials and powers--essential to human dignity. This…

  15. The Value of Accounting

    NARCIS (Netherlands)

    E. Peek (Erik)

    2011-01-01

    textabstractFair value estimates of debt and equity securities play an increasingly important role in the economy. For example, International Financial Reporting Standards require companies to report many of their investments at fair value on the balance sheet or to use fair values in goodwill

  16. Value activity monitoring

    NARCIS (Netherlands)

    de Alencar Silva, P.

    2013-01-01

    Current value modeling ontologies are grounded on the economic premise that profit sharing is a critical condition to be assessed during the configuration of a value constellation. Such a condition ought to be reinforced through a monitoring mechanism design, since a value model expresses only

  17. Five values of giftedness

    NARCIS (Netherlands)

    Besjes, K.M.; de Ruyter, D.J.

    2011-01-01

    This article describes five values attributed to giftedness. The ascription of values to this phenomenon resembles values attached to gifts in gift-giving processes. Whereas gift-giving often includes expectations of reciprocity, each gift possesses a numerical, utility, social, personal, and

  18. Anti-HIV-1 integrase activity of medicinal plants used as self medication by AIDS patients

    Directory of Open Access Journals (Sweden)

    Sopa Kummee

    2006-07-01

    Full Text Available The extracts of selected medicinal plants used as self medication by AIDS patients were investigated for their inhibitory activities against HIV-1 integrase (HIV-1 IN using the multiplate integration assay (MIA. Of these, the water extract of Eclipta prostrata (whole plant exhibited the most potent inhibitory activity with an IC50 value of 4.8 μg/ml, followed by the methanol extract of Eclipta prostrata (whole plant, IC50 = 21.1 μg/ ml, the water extract of Barleria lupulina (stem, IC50 = 26.4 μg/ml, the chloroform extract of Barleria lupulina (stem, IC50 = 33.0 μg/ml, the methanol extract of Barleria lupulina (stem, IC50 = 38.2 μg/ml and the chloroform extract of Piper betle (leaf, IC50 = 39.3 μg/ml, respectively.

  19. Antitumor potential of crown ethers: structure-activity relationships, cell cycle disturbances, and cell death studies of a series of ionophores.

    Science.gov (United States)

    Marjanović, Marko; Kralj, Marijeta; Supek, Fran; Frkanec, Leo; Piantanida, Ivo; Smuc, Tomislav; Tusek-Bozić, Ljerka

    2007-03-08

    The present paper demonstrates the antiproliferative ability and structure-activity relationships (SAR) of 14 crown and aza-crown ether analogues on five tumor-cell types. The most active compounds were di-tert-butyldicyclohexano-18-crown-6 (3), which exhibited cytotoxicity in the submicromolar range, and di-tert-butyldibenzo-18-crown-6 (5) (IC50 values of approximately 2 microM). Also, 3 and 5 induced marked influence on the cell cycle phase distribution--strong G1 arrest, followed by the induction of apoptosis. A computational SAR modeling effort offers insight into possible mechanisms of crown ether biological activity, presumably involving penetration into cell membranes, and points out structural features of molecules important for this activity. The results reveal that crown ethers possess marked tumor-cell growth inhibitory activity, the extent of which depends on the characteristics of the hydrophilic macrocylic cavity and the surrounding hydrophobic ring. Our work supports the hypothesis that crown ether compounds inhibit tumor-cell growth by disrupting potassium ion homeostasis, which in turn leads to cell cycle perturbations and apoptosis.

  20. Design, synthesis, in vitro Evaluation and docking studies on dihydropyrimidine-based urease inhibitors.

    Science.gov (United States)

    Iftikhar, Fatima; Ali, Yousaf; Ahmad Kiani, Farooq; Fahad Hassan, Syed; Fatima, Tabeer; Khan, Ajmal; Niaz, Basit; Hassan, Abbas; Latif Ansari, Farzana; Rashid, Umer

    2017-10-01

    In our previous report, we have identified 3,4-dihydropyrimidine scaffold as promising class of urease inhibitor in a structure based virtual screen (SBVS) experiment. In present study, we attempted to optimize the scaffold by varying C-5 substituent. The elongation of the C-5 chain was achieved by the reaction of C-5 ester with hydrazine leading to C-5 carbohydrazides which were further used as building blocks for the synthesis of fifteen new compounds having diverse moieties. A significantly higher in vitro urease inhibitory activity with IC 50 values in submicromolar range was observed for semithiocarbazide derivatives (4a-c, 0.58-0.79µM) and isatin Schiff base derivative 5a (0.23µM). Docking analysis suggests that the synthesized compounds were anchored well in the catalytic site and extending to the entrance of binding pocket and thus restrict the mobility of the flap by interacting with its key amino acid residues. The overall results of urease inhibition have shown that these compounds can be further optimized and developed as lead urease inhibitors. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects

    Directory of Open Access Journals (Sweden)

    Mohamed Alswah

    2017-12-01

    Full Text Available A series of hybrid of triazoloquinoxaline-chalcone derivatives 7a–k were designed, synthesized, fully characterized, and evaluated for their cytotoxic activity against three target cell lines: human breast adenocarcinoma (MCF-7, human colon carcinoma (HCT-116, and human hepatocellular carcinoma (HEPG-2. The preliminary results showed that some of these chalcones like 7b–c, and 7e–g exhibited significant antiproliferative effects against most of the cell lines, with selective or non-selective behavior, indicated by IC50 values in the 1.65 to 34.28 µM range. In order to investigate the mechanistic aspects of these active compounds, EGFR TK and tubulin inhibitory activities were measured as further biological assays. The EGFR TK assay results revealed that the derivatives 7a–c, 7e, and 7g could inhibit the EGFR TK in the submicromolar range (0.093 to 0.661 µM. Moreover, an antitubulin polymerization effect was noted for the active derivatives compared to the reference drug colchicine, with compounds 7e and 7g displaying 14.7 and 8.4 micromolar activity, respectively. Furthermore, a molecular docking study was carried out to explain the observed effects and the binding modes of these chalcones with the EGFR TK and tubulin targets.

  2. Deciphering structure-activity relationships in a series of Tat/TAR inhibitors.

    Science.gov (United States)

    Pascale, Lise; González, Alejandro López; Di Giorgio, Audrey; Gaysinski, Marc; Teixido Closa, Jordi; Tejedor, Roger Estrada; Azoulay, Stéphane; Patino, Nadia

    2016-11-01

    A series of pentameric "Polyamide Amino Acids" (PAAs) compounds derived from the same trimeric precursor have been synthesized and investigated as HIV TAR RNA ligands, in the absence and in the presence of a Tat fragment. All PAAs bind TAR with similar sub-micromolar affinities but their ability to compete efficiently with the Tat fragment strongly differs, IC50 ranging from 35 nM to >2 μM. While NMR and CD studies reveal that all PAA interact with TAR at the same site and induce globally the same RNA conformational change upon binding, a comparative thermodynamic study of PAA/TAR equilibria highlights distinct TAR binding modes for Tat competitor and non-competitor PAAs. This led us to suggest two distinct interaction modes that have been further validated by molecular modeling studies. While the binding of Tat competitor PAAs induces a contraction at the TAR bulge region, the binding of non-competitor ones widens it. This could account for the distinct PAA ability to compete with Tat fragment. Our work illustrates how comparative thermodynamic studies of a series of RNA ligands of same chemical family are of value for understanding their binding modes and for rationalizing structure-activity relationships.

  3. Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains.

    Science.gov (United States)

    Tasso, Bruno; Novelli, Federica; Tonelli, Michele; Barteselli, Anna; Basilico, Nicoletta; Parapini, Silvia; Taramelli, Donatella; Sparatore, Anna; Sparatore, Fabio

    2015-09-01

    Chloroquine is commonly used in the treatment and prevention of malaria, but Plasmodium falciparum, the main species responsible for malaria-related deaths, has developed resistance against this drug. Twenty-seven novel chloroquine (CQ) analogues characterized by a side chain terminated with a bulky basic head group, i.e., octahydro-2H-quinolizine and 1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, were synthesized and tested for activity against D-10 (CQ-susceptible) and W-2 (CQ-resistant) strains of P. falciparum. Most compounds were found to be active against both strains with nanomolar or sub-micromolar IC50 values. Eleven compounds were found to be 2.7- to 13.4-fold more potent than CQ against the W-2 strain; among them, four cytisine derivatives appear to be of particular interest, as they combine high potency with low cytotoxicity against two human cell lines (HMEC-1 and HepG2) along with easier synthetic accessibility. Replacement of the 4-NH group with a sulfur bridge maintained antiplasmodial activity at a lower level, but produced an improvement in the resistance factor. These compounds warrant further investigation as potential drugs for use in the fight against malaria. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Weak value controversy

    Science.gov (United States)

    Vaidman, L.

    2017-10-01

    Recent controversy regarding the meaning and usefulness of weak values is reviewed. It is argued that in spite of recent statistical arguments by Ferrie and Combes, experiments with anomalous weak values provide useful amplification techniques for precision measurements of small effects in many realistic situations. The statistical nature of weak values is questioned. Although measuring weak values requires an ensemble, it is argued that the weak value, similarly to an eigenvalue, is a property of a single pre- and post-selected quantum system. This article is part of the themed issue `Second quantum revolution: foundational questions'.

  5. Extreme value distributions

    CERN Document Server

    Ahsanullah, Mohammad

    2016-01-01

    The aim of the book is to give a through account of the basic theory of extreme value distributions. The book cover a wide range of materials available to date. The central ideas and results of extreme value distributions are presented. The book rwill be useful o applied statisticians as well statisticians interrested to work in the area of extreme value distributions.vmonograph presents the central ideas and results of extreme value distributions.The monograph gives self-contained of theory and applications of extreme value distributions.

  6. Managing Customer Value

    OpenAIRE

    William B. Dodds

    1999-01-01

    This paper builds the framework for linking the established work of competitive advantage with the emerging discipline of value marketing. The outcome of this linkage is the concept of strategic value management. Strategic value management focuses on the right combinations of product quality, customer service and fair prices as the key to selling to todayÕs value conscious consumers. The core of the strategy stresses the firmÕs ability to combine and manage these dimensions of value in a way ...

  7. Public Value Dimensions

    DEFF Research Database (Denmark)

    Andersen, lotte bøgh; Beck Jørgensen, Torben; Kjeldsen, Anne-Mette

    2012-01-01

    Further integration of the public value literature with other strands of literature within Public Administration necessitates a more specific classification of public values. This paper applies a typology linked to organizational design principles, because this is useful for empirical public...... administration studies. Based on an existing typology of modes of governance, we develop a classification and test it empirically, using survey data from a study of the values of 501 public managers. We distinguish between seven value dimensions (the public at large, rule abidance, societal interests, budget...... the integration between the public value literature and other parts of the Public Administration discipline....

  8. Recovery actinide values

    International Nuclear Information System (INIS)

    Horwitz, E.P.; Delphin, W.H.; Mason, G.W.

    1979-01-01

    A process is described for partitioning and recovering actinide values from acidic waste solutions resulting from reprocessing of irradiated nuclear fuels by adding hydroxylammonium nitrate and hydrazine to the waste solution to adjust the valence of the neptunium and plutonium values in the solution to the +4 oxidation state, thus forming a feed solution and contacting the feed solution with an extractant of di-hexoxyethyl phosphoric acid in an organic diluent whereby the actinide values, most of the rare earth values and some fission product values are taken up by the extractant. Separation is achieved by contacting the loaded extractant with two aqueous strip solutions, a nitric acid solution to selectively strip the americium, curium and rare earth values and an oxalate solution of tetramethylammonium hydrogen oxalate and oxalic acid or trimethylammonium hydrogen oxalate to selectively strip the neptunium, plutonium and fission product values. Uranium values remain in the extractant and may be recovered with a phosphoric acid strip. The neptunium and plutonium values are recovered from the oxalate by adding sufficient nitric acid to destroy the complexing ability of the oxalate, forming a second feed, and contacting the second feed with a second extractant of tricaprylmethylammonium nitrate in an inert diluent whereby the neptunium and plutonium values are selectively extracted. The values are recovered from the extractant with formic acid. (author)

  9. Closing the value gap

    International Nuclear Information System (INIS)

    Snyder, A.V.

    1992-01-01

    It's a predicament. For the most part, investor-owned electric utilities trade at a deep discount to the actual (that is, replacement-cost) value to their assets. That's because most utilities fail to earn real returns large enough to justify raising and investing capital. The result is a value gap, where overall market value is significantly lower than the replacement costs of the assets. This gap is wider for utilities than for virtually any other industry in our economy. In addition to providing education and awareness, senior management must determine which businesses and activities create value and which diminish it. Then, management must allocate capital and human resources appropriately, holding down investments in value-diminishing areas until they can improve their profitability, and aggressively investing in value-enhancing businesses while preserving their profitability. But value management must not stop with resource-allocation decisions. To create a lasting transition to a value management philosophy, the utility's compensation system must also change: executives will have motivation to create value when compensation stems from this goal, not from such misleading accounting measures as earnings-per-share growth or ROE. That requires clear value-creation goals, and the organization must continuously evaluate top management's performance in light of the progress made toward those goals

  10. Value reprioritization in psychoanalysis.

    Science.gov (United States)

    Horowitz, Mardi J

    2009-12-01

    As psychoanalysts, we sometimes seem to regard values as radioactive materials that must be handled with heavy lead gloves. But the gloves should not be so thick that they interfere with the goal of sorting out values. Reasons for our hesitation to deal with issues related to values may include real disagreements with the morals of a patient, a fear of evoking unproductive and negative emotional states, and our own unresolved conflicts about value dilemmas. Psychoanalytic technique should at times include clear verbal statements of values. By being explicit about what is often implicit, we can help our patients in their work of ameliorating harsh, primitive, and critical attitudes and to self-own rules, principles, and codes of conduct. A patient with reprioritized personal values may then function with heightened interpersonal compassion, kindness, and cooperation, gaining in return love, intimacy, respect, and self-esteem.

  11. Baudrillard's Theory of Value

    DEFF Research Database (Denmark)

    Zander, Pär Ola

    2014-01-01

    theory. The paper concludes that Baudrillard's arguments for abandoning Marxism altogether are problematic and led him away from developing a more finished theory of value. This is unfortunate because it remains a project that may yield interesting insights even in contemporary social theory, not least......Jean Baudrillard outlined a theory of value in his early writings that built on, but also criticized, Marxist concepts of use value and exchange value. In this paper, I use a close reading to delineate the diachronic transition of Baudrillard's writings toward anti-Marxism and (allegedly......) postmodernism, with specific focus on his value theory, in order to understand his own reasons for abandoning his previous position. I then follow the marginal stream of scholars who are making use of the early Baudrillard. I find his value theory promising but still a mere sketch rather than an actual general...

  12. Value oriented strategic marketing

    Directory of Open Access Journals (Sweden)

    Milisavljević Momčilo

    2013-01-01

    Full Text Available Changes in today's business environment require companies to orient to strategic marketing. The company accepting strategic marketing has a proactive approach and focus on continuous review and reappraisal of existing and seeking new strategic business areas. Difficulties in achieving target profit and growth require turning marketing from the dominant viewpoint of the tangible product to creating superior value and developing relationships with customers. Value orientation implies gaining competitive advantage through continuous research and understanding of what value represents to the consumers and discovering new ways to meet their required values. Strategic marketing investment requires that the investment in the creation of values should be regularly reviewed in order to ensure a focus on customers with high profit potential and environmental value. This increases customer satisfaction and retention and long-term return on investment of companies.

  13. The problem with value

    Science.gov (United States)

    O’Doherty, John P.

    2015-01-01

    Neural correlates of value have been extensively reported in a diverse set of brain regions. However, in many cases it is difficult to determine whether a particular neural response pattern corresponds to a value-signal per se as opposed to an array of alternative non-value related processes, such as outcome-identity coding, informational coding, encoding of autonomic and skeletomotor consequences, alongside previously described “salience” or “attentional” effects. Here, I review a number of experimental manipulations that can be used to test for value, and I identify the challenges in ascertaining whether a particular neural response is or is not a value signal. Finally, I emphasize that some non-value related signals may be especially informative as a means of providing insight into the nature of the decision-making related computations that are being implemented in a particular brain region. PMID:24726573

  14. Adding more value to added-value

    DEFF Research Database (Denmark)

    Marian, Livia

    Recent studies reveal that consumers respond favourably to “organic plus” products with additional ethical attributes. The aim of the current study is to explore whether consumers would notice and value further improvements in the animal welfare standards than those imposed by the organic...... regulation. The results of a qualitative concept test reveal positive attitudes towards the proposed production process. The discussions about fewer standards being sufficient or about options “in-between” conventional and organic standards indicate that the difference in production processes is noticed, yet...

  15. Behavioural present value

    OpenAIRE

    Krzysztof Piasecki

    2013-01-01

    Impact of chosen behavioural factors on imprecision of present value is discussed here. The formal model of behavioural present value is offered as a result of this discussion. Behavioural present value is described here by fuzzy set. These considerations were illustrated by means of extensive numerical case study. Finally there are shown that in proposed model the return rate is given, as a fuzzy probabilistic set.

  16. Nordic Noir Production Values

    DEFF Research Database (Denmark)

    Waade, Anne Marit; Jensen, Pia Majbritt

    2013-01-01

    In this article the authors argue that Nordic noir constitutes a set of production values utilised and conceptualised to make Danish television series attractive in the international market. The idea of production values is embedded into a media industrial context where market principles of target...... by relating the specific Nordic noir production values present in the two series to changing conditions in Danish television drama production, in particular the internationalisation of DR’s Drama Division....

  17. Institution-specific value

    OpenAIRE

    Ken Peasnell

    2006-01-01

    The introduction of a new accounting standard for financial instruments, has raised a number of issues related to the application of fair value principles. This paper discusses some of these issues which are generally related to the fact that "fair values" are not always easily defined or readily available. It concludes that the application of fair value for financial liabilities might present fewer complications if it is matched by similar valuation principles for financial assets. The issue...

  18. Values and entrepreneurship

    Directory of Open Access Journals (Sweden)

    Martina Urbanová

    2013-01-01

    Full Text Available This paper deals with the importance of values ​​in business development. The authors remind M. Weber and his study about the impact of Protestantism on business development. After defining the concept of value, attention is focused on the theory of R.K. Merton, T. Parsons, R. Inglehart. Using the critical sociological approach the authors reflect on the research strategies in the area of values. In this context is mentioned for example the issue of ideal and real cultures – ideal cultures consist of norms and values to which people officially claim, e.g. values of Christian civilization, values of Central Europe; so-called universal values are very often (or should be a base for legal norms. Real cultures represent a pattern according to which people act and regard it socially acceptable. In this context is also discussed the question of individualism without responsibility that is typical for current western society as well as for the Czech society of last decades. Value orientations are patterns for expected roles, culturally defined types of human relations, expressing the basic attitudes in social interaction. The level of prevailing business values is visible also in many multinational corporations espousing the concept of corporate social responsibility within their promotion but violating it in reality.

  19. Antiproliferative activity of protein extracts from the black clam ...

    African Journals Online (AJOL)

    MB-231 cell lines with IC50 values of 138.035 and 157.19 μg/ml, respectively, and 2F2 showed IC50 values of 67.46 μg/ml on HeLa cells. These results suggest that protein extracts from C. fluctifraga might be potential anticancer agents.

  20. Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle

    NARCIS (Netherlands)

    Vliet, A.K. van; Nègre-Arrariou, P.; Thiel, G.C.F. van; Bolhuis, P.A.; Cohen, L.H.

    1996-01-01

    Lovastatin, simvastatin, and pravastatin are fairly strong inhibitors of sterol synthesis in human myoblasts in culture. Lovastatin and simvastatin have IC50 values of 19 ± 6 nM and 4.0 ± 2.3 nM, respectively. Pravastatin is a weaker inhibitor of sterol synthesis (IC50 value of 110 ± 38 nM). Through

  1. The Prediction Value

    NARCIS (Netherlands)

    Koster, M.; Kurz, S.; Lindner, I.; Napel, S.

    2013-01-01

    We introduce the prediction value (PV) as a measure of players’ informational importance in probabilistic TU games. The latter combine a standard TU game and a probability distribution over the set of coalitions. Player i’s prediction value equals the difference between the conditional expectations

  2. Dance: Verities, Values, Visions.

    Science.gov (United States)

    Boorman, Joyce, Ed.; Harris, Dorothy, Ed.

    The Binational Dance Conference was organized into three focal themes--verities, values, and visions in dance--to emphasize the known and accepted worth and value of dance, and to stimulate through knowledge and idea exchange, imaginative directions for dance in the future of both the United States and Canada. This thematic structure is also the…

  3. Value Chain Engineering

    DEFF Research Database (Denmark)

    Wæhrens, Brian Vejrum; Slepniov, Dmitrij

    2015-01-01

    This workbook is recommended for the attention of students of and managers in Danish small and medium sized enterprises (SMEs). Danish SMEs are currently facing a number of key challenges related to their position in global value chains. This book provides an insight into value chain management t...

  4. Values in dialogic pedagogy

    Directory of Open Access Journals (Sweden)

    Eugene Matusov

    2015-02-01

    Full Text Available In November 2014 on the Dialogic Pedagogy Journal Facebook page, there was an interesting discussion of the issue of values in dialogic pedagogy[1]. The main issue can be characterized as the following. Should dialogic pedagogy teach values? Should it avoid teaching values? Is there some kind of a third approach? The participants of the Facebook discussions were focusing on teaching values in dialogic pedagogy and not about teaching aboutvalues. On the one hand, it seems to be impossible to avoid teaching values. However, on the other hand, shaping students in some preset molding is apparently non-dialogic and uncritical (Matusov, 2009. In the former case, successful teaching is defined by how well and deeply the students accept and commit to the taught values. In the latter case, successful dialogic teaching may be defined by students’ critical examination of their own values against alternative values in a critical dialogue. Below, Eugene Matusov and Jay Lemke, active participants of this Facebook dialogue, provide their reflection on this important issue and encourage readers to join their reflective dialogue.[1] See in a public Facebook domain: https://www.facebook.com/DialogicPedagogyJournal/posts/894734337204533, https://www.facebook.com/DialogicPedagogyJournal/posts/896916850319615

  5. Wildlife value orientations

    DEFF Research Database (Denmark)

    Gamborg, Christian; Jensen, Frank Søndergaard

    2016-01-01

    This article examined value orientations toward wildlife among the adult general Danish public in relation to age, sex, past and present residence, education, and income, using a U.S. survey instrument on Wildlife Value Orientations (WVO). The study used an Internet-based questionnaire sent...

  6. Value of travel time.

    Science.gov (United States)

    2016-08-01

    Knowingly or not, people generally place economic value on their time. Wage workers are paid a rate per hour, and service providers may charge per hour of their time. In the transportation realm, travelers place a value on their travel time and have ...

  7. Management Values Survey Results.

    Science.gov (United States)

    Duffy, Barbara; Payne, Ron

    1988-01-01

    Describes results of a survey conducted to compare values of members of the Association for Educational Communications and Technology (AECT) with managers in business and industry. Issues discussed include job satisfaction, opportunities for advancement, attitudes toward management, and salary; a summary of each value system is provided. (LRW)

  8. Do We Value Caring?

    Science.gov (United States)

    Weissbourd, Richard; Anderson, Trisha Ross

    2016-01-01

    When asked about their child-rearing priorities, parents in the United States are likely to say it's more important to raise children who are caring than to raise high achievers. Schools, too, typically trumpet values such as caring, honesty, and fairness. These values are posted on walls, reiterated in assemblies, and included in mission…

  9. Work Values across Generations

    Science.gov (United States)

    Hansen, Jo-Ida C.; Leuty, Melanie E.

    2012-01-01

    Mainstream publication discussions of differences in generational cohorts in the workplace suggest that individuals of more recent generations, such as Generation X and Y, have different work values than do individuals of the Silent and Baby Boom generations. Although extant research suggests that age may influence work values, few of the…

  10. High coking value pitch

    Science.gov (United States)

    Miller, Douglas J.; Chang, Ching-Feng; Lewis, Irwin C.; Lewis, Richard T.

    2014-06-10

    A high coking value pitch prepared from coal tar distillate and has a low softening point and a high carbon value while containing substantially no quinoline insolubles is disclosed. The pitch can be used as an impregnant or binder for producing carbon and graphite articles.

  11. Extraction of metal values

    Energy Technology Data Exchange (ETDEWEB)

    Dalton, R F

    1988-10-19

    Metal values (especially uranium values) are extracted from aqueous solutions of metal oxyions in the absence of halogen ion using an imidazole of defined formula. Especially preferred extractants are 1-alkyl imidazoles and benzimidazoles having from 7 to 25 carbon atoms in the alkyl group.

  12. Social Life of Values

    NARCIS (Netherlands)

    S.J. Magala (Slawomir)

    2006-01-01

    textabstractThe case of the Danish “cartoon war” was a premonition of things to come: accelerated social construction of inequalities and their accelerated symbolic communication, translation and negotiation. New uses of values in organizing and managing inequalities emerge. Values lead active

  13. Valuing and pricing IPOs

    NARCIS (Netherlands)

    P.G.J. Roosenboom (Peter)

    2012-01-01

    textabstractThis paper investigates how underwriters set the IPO firm’s fair value, an ex-ante estimate of the market value, using a unique dataset of 228 reports from French underwriters. These reports are issued before the IPO shares start trading on the stock market and detail how underwriters

  14. Many-valued logics

    CERN Document Server

    Bolc, Leonard

    1992-01-01

    Many-valued logics were developed as an attempt to handle philosophical doubts about the "law of excluded middle" in classical logic. The first many-valued formal systems were developed by J. Lukasiewicz in Poland and E.Post in the U.S.A. in the 1920s, and since then the field has expanded dramatically as the applicability of the systems to other philosophical and semantic problems was recognized. Intuitionisticlogic, for example, arose from deep problems in the foundations of mathematics. Fuzzy logics, approximation logics, and probability logics all address questions that classical logic alone cannot answer. All these interpretations of many-valued calculi motivate specific formal systems thatallow detailed mathematical treatment. In this volume, the authors are concerned with finite-valued logics, and especially with three-valued logical calculi. Matrix constructions, axiomatizations of propositional and predicate calculi, syntax, semantic structures, and methodology are discussed. Separate chapters deal w...

  15. The triad value function

    DEFF Research Database (Denmark)

    Vedel, Mette

    2016-01-01

    the triad value function. Next, the applicability and validity of the concept is examined in a case study of four closed vertical supply chain triads. Findings - The case study demonstrates that the triad value function facilitates the analysis and understanding of an apparent paradox; that distributors...... are not dis-intermediated in spite of their limited contribution to activities in the triads. The results indicate practical adequacy of the triad value function. Research limitations/implications - The triad value function is difficult to apply in the study of expanded networks as the number of connections...... expands exponentially with the number of ties in the network. Moreover, it must be applied in the study of service triads and open vertical supply chain triads to further verify the practical adequacy of the concept. Practical implications - The triad value function cannot be used normatively...

  16. The value of space

    DEFF Research Database (Denmark)

    Panduro, Toke Emil

    The thesis consists of four papers which address the potential and challenges of the hedonic house price method. The aim of the thesis has been to estimate consistent and efficient parameter estimates of spatial varying regressors in the hedonic house price model. In particular, the articles are ...... and provide reliable estimates of the value of different types of green space....... are concerned with the value of different types of green space and how these values can be applied in urban planning policies related to climate adaption. The results presented in this thesis, ensure a “level playing field” in the assessment of the cost and benefits of different climate adaptation strategies...

  17. The Value of Architecture

    DEFF Research Database (Denmark)

    Beim, Anne

    2018-01-01

    of Europe’s architectural heritage. This resulted in a greater emphasis on building conservation and led to the development of the Survey of Architectural Values in the Environment (SAVE) by the Danish heritage authorities. The value assessment was initially meant for evaluating building heritage...... and authorities in efforts to evaluate the cultural value of the built environment. The National Trust of Norway is a voluntary association, a trust, and a property owner. Since 1845, it has developed expertise in restoration and maintenance of historical monuments. It is based on personal memberships...

  18. Plastic value chains

    DEFF Research Database (Denmark)

    Baxter, John; Wahlstrom, Margareta; Zu Castell-Rüdenhausen, Malin

    2014-01-01

    Optimizing plastic value chains is regarded as an important measure in order to increase recycling of plastics in an efficient way. This can also lead to improved awareness of the hazardous substances contained in plastic waste, and how to avoid that these substances are recycled. As an example......, plastics from WEEE is chosen as a Nordic case study. The project aims to propose a number of improvements for this value chain together with representatives from Nordic stakeholders. Based on the experiences made, a guide for other plastic value chains shall be developed....

  19. Value Proposition Canvas

    DEFF Research Database (Denmark)

    Kyhnau, Jan Glæsner

    2017-01-01

    Alexander Osterwalders Value Proposition Canvas hjælper virksomheder med at udvikle produkter og services, som kunderne rent faktisk vil have. Modellen zoomer ind på de to grundlæggende byggesten i Business Model Canvas Customer Segments og Value Propositions og kortlægger, hvilket match der er...... mellem kundernes behov og virksomhedens evne til at opfylde disse. Modellen afslører gaps og dermed hvilke forbedringer eller innovationer der er brug for. "Value Proposition Canvas" er et kapitel i bogen "Marketingmodeller" - en kort og overskuelig håndbog, værktøjskasse og brugervejledning med de...

  20. Reference values for electrooculography

    International Nuclear Information System (INIS)

    Barrientos Castanno, Alberto; Herrera Mora, Maritza; Garcia Baez, Obel

    2012-01-01

    Obtain electrooculographic reference values based on the patterns set by the Standardization Committee of the International Society for Clinical Electrophysiology of Vision (ISCEV). the lowest amplitude values of the potential ranged between 388 and 882 μv in the dark phase. The light peak was obtained between 9 and 10 minutes, and during this phase the potential reached an amplitude ranging between 808 and 1 963 μv. This amplitude variability may be related to the fact that the test was conducted without pupillary mydriasis. The reference value obtained for Arden index was 1,55 to 2,87

  1. VT Wildlife Crossing Value

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) WCV describes the value of the Wildlife Habitat Suitability as it approaches the state highway system. This analysis was designed to use the...

  2. Moldova - Value Chain Training

    Data.gov (United States)

    Millennium Challenge Corporation — The evaluation of the GHS value chain training subactivity wwas designed to measure the extent, if any, to which the training activities improved the productivity...

  3. Earned Value Management System

    Data.gov (United States)

    US Agency for International Development — EVMS is a system for measuring project performance and progress in an objective manner by supporting earned value management. EVMS has the ability to combine...

  4. Revisiting enduring values

    Directory of Open Access Journals (Sweden)

    Michael Gorman

    2015-05-01

    Full Text Available The paper discusses the nature of values in general and the nature and utility of the values of librarianship.  Delineates the changes that have occurred and are occurring in the wider world and the nature of change; also the importance of values in providing a framework for dealing with present and future change.  Stresses the centrality of the human record to societal progress, the place of the human record in cultural heritage, and the central purpose of libraries in facilitating interaction with the human record and furthering the transmission of cultural heritage.  Urges a turning away from the alien value systems of information technology, consumerism, materialism, and corporate management, and a consequent set of alliances between libraries and a wide range of cultural institutions and associations.

  5. Comparability of reference values

    International Nuclear Information System (INIS)

    Rossbach, M.; Stoeppler, M.

    1993-01-01

    Harmonization of certified values in Reference Materials (RMs) can be carried out by applying nuclear analytical techniques to RMs of various matrix types and concentration levels. Although RMs generally should not be used as primary standards the cross evaluation of concentrations in RMs leads to better compatibility of reference values and thus to a greater agreement between analytical results from different laboratories using these RMs for instrument calibration and quality assurance. (orig.)

  6. Occupational choice and values.

    OpenAIRE

    Kantas, A.

    1985-01-01

    It is suggested that psychological and sociological approaches to occupational choice can be linked together by employment of three concepts: work salience, values and motivation. Employing Vroom's (1964) cognitive model of motivation occupational choice was examined as a value attainment process. The subjects were 225 male pupils of two different school complexes in Athens, Greece. They were asked to respond to a work salience questionnaire and to rank order a set of ...

  7. Stakeholder Values and Ecosystems

    OpenAIRE

    Sveinsdottir, Thordis; Wessels, Bridgette; Smallwood, Rod; Linde, Peter; Kalla, Vasso; Tsoukala, Victoria; Sondervan, Jeroen

    2013-01-01

    This report is the deliverable for Work Package 1 (WP1), Stakeholder Values and Ecosystems, of the EU FP7 funded project RECODE (Grant Agreement No: 321463), which focuses on developing Policy Recommendations for Open Access to Research Data in Europe. WP1 focuses on understanding stakeholder values and ecosystems in Open Access, dissemination and preservation in the area of scientific and scholarly data (thus not government data). The objectives of this WP are as follows: • Identify and map ...

  8. Age and Value Orientations

    Directory of Open Access Journals (Sweden)

    Asya Kh. Kukubayeva

    2013-01-01

    Full Text Available The present article deals with value orientations and their role in men’s lives, particularly, in young people’s lives. This notion was introduced by the American theoretical sociologist T. Parsons, one of the creators of modern theoretical sociology. The scientist made an attempt to construct the structural and analytical theory of social action, combining personal interests (needs and aims and situation, it takes place in. The issue of value orientations remains acute for psychology. Herein we have considered several most important works, relating to the considered issue. Age aspects of young people’s value orientations are of peculiar interest to us. When analyzing this phenomenon, one should take into consideration the psychological formations, inhere for a certain age. In fact every age has its unique structure, which may change when passing from one development stage to another. Basing on this fact, we’ve considered the values, depending on the age features of the youth, relying upon the works of the scientists, working with different categories of the youth, such as: teenagers, students, children of different nationalities. It is not surprising that most scientists have come to the conclusion that the chief role in value orientation belongs to a family, originates in relations with parents and teachers. The positive reinforcement to the future develops throughout life in accordance with a lifestyle of a family, society and political situation in a state.Life orientations as a type of value orientations show different types of young people’s preferences. Value structure of its consciousness has its own specific character, depending on the age peculiarities. The dynamics of the transition from one age to another is accompanied with the reappraisal of values, eventually, influencing the life strategy of the future generation

  9. Company Value Anatomy

    Directory of Open Access Journals (Sweden)

    Luiz Nelson Guedes de Carvalho

    2008-10-01

    Full Text Available The seminal propositions by Modigliani and Miller started a new study area in modern finance theory. Over time, their basic assumptions were relaxed, to the extent that, nowadays, situations in which they can be fully applied, with consistent and satisfactory results, are rare. On the other hand, as this simple set of propositions became known worldwide and was easily applicable, it was adopted as a rule of thumb for general enterprise valuation. However, in situations without methodological bias, the resulting enterprise values obtained by traditional methodologies are abstruse and do not allow for the analysis and management of the individual values that make up the firm and own capital values. In order to avoid this kind of abstruseness in company valuation, this study theoretically deducts an alternative valuation methodology, which permits the identification of assets’ value independently of their financing; moreover, we identify the gain on debt value that the debt provides to the shareholders, the debt tax shield and the value loss of assets and tax shield due to the increase in shareholder risk because of the leverage capital structure.

  10. Anomalous vacuum expectation values

    International Nuclear Information System (INIS)

    Suzuki, H.

    1986-01-01

    The anomalous vacuum expectation value is defined as the expectation value of a quantity that vanishes by means of the field equations. Although this value is expected to vanish in quantum systems, regularization in general produces a finite value of this quantity. Calculation of this anomalous vacuum expectation value can be carried out in the general framework of field theory. The result is derived by subtraction of divergences and by zeta-function regularization. Various anomalies are included in these anomalous vacuum expectation values. This method is useful for deriving not only the conformal, chiral, and gravitational anomalies but also the supercurrent anomaly. The supercurrent anomaly is obtained in the case of N = 1 supersymmetric Yang-Mills theory in four, six, and ten dimensions. The original form of the energy-momentum tensor and the supercurrent have anomalies in their conservation laws. But the modification of these quantities to be equivalent to the original one on-shell causes no anomaly in their conservation laws and gives rise to anomalous traces

  11. Sustained Submicromolar H2O2 Levels Induce Hepcidin via Signal Transducer and Activator of Transcription 3 (STAT3)*

    Science.gov (United States)

    Millonig, Gunda; Ganzleben, Ingo; Peccerella, Teresa; Casanovas, Guillem; Brodziak-Jarosz, Lidia; Breitkopf-Heinlein, Katja; Dick, Tobias P.; Seitz, Helmut-Karl; Muckenthaler, Martina U.; Mueller, Sebastian

    2012-01-01

    The peptide hormone hepcidin regulates mammalian iron homeostasis by blocking ferroportin-mediated iron export from macrophages and the duodenum. During inflammation, hepcidin is strongly induced by interleukin 6, eventually leading to the anemia of chronic disease. Here we show that hepatoma cells and primary hepatocytes strongly up-regulate hepcidin when exposed to low concentrations of H2O2 (0.3–6 μm), concentrations that are comparable with levels of H2O2 released by inflammatory cells. In contrast, bolus treatment of H2O2 has no effect at low concentrations and even suppresses hepcidin at concentrations of >50 μm. H2O2 treatment synergistically stimulates hepcidin promoter activity in combination with recombinant interleukin-6 or bone morphogenetic protein-6 and in a manner that requires a functional STAT3-responsive element. The H2O2-mediated hepcidin induction requires STAT3 phosphorylation and is effectively blocked by siRNA-mediated STAT3 silencing, overexpression of SOCS3 (suppressor of cytokine signaling 3), and antioxidants such as N-acetylcysteine. Glycoprotein 130 (gp130) is required for H2O2 responsiveness, and Janus kinase 1 (JAK1) is required for adequate basal signaling, whereas Janus kinase 2 (JAK2) is dispensable upstream of STAT3. Importantly, hepcidin levels are also increased by intracellular H2O2 released from the respiratory chain in the presence of rotenone or antimycin A. Our results suggest a novel mechanism of hepcidin regulation by nanomolar levels of sustained H2O2. Thus, similar to cytokines, H2O2 provides an important regulatory link between inflammation and iron metabolism. PMID:22932892

  12. Determination of submicromolar amounts of uranium(VI) by compleximetric titration with pyridine-2,6-dicarboxylic acid

    International Nuclear Information System (INIS)

    Marsh, S.F.; Betts, M.R.; Rein, J.E.

    1980-01-01

    Uranium(VI) is selectively determined by a compleximetric titration with pyridine-2,6-dicarboxylic acid, using arsenazo-I indicator and hexamethylenetetramine buffer at pH 4.9. Cyclohexanediaminetetraacetic acid and diethylenetriaminepentaacetic acid provide masking of interfering metal ions. A probe colorimeter apparatus is recommended for end-point detection. The relative standard deviation is 0.6% for 0.17-0.76 μmol of uranium. (Auth.)

  13. Determination of submicromolar amounts of uranium(VI) by compleximetric titration with pyridine-2,6-dicarboxylic acid

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, S F; Betts, M R; Rein, J E [Los Alamos Scientific Lab., NM (USA)

    1980-10-01

    Uranium(VI) is selectively determined by a compleximetric titration with pyridine-2,6-dicarboxylic acid, using arsenazo-I indicator and hexamethylenetetramine buffer at pH 4.9. Cyclohexanediaminetetraacetic acid and diethylenetriaminepentaacetic acid provide masking of interfering metal ions. A probe colorimeter apparatus is recommended for end-point detection. The relative standard deviation is 0.6% for 0.17-0.76 ..mu..mol of uranium.

  14. Value encounters - Modeling and analyzing co-creation of value

    NARCIS (Netherlands)

    Weigand, H.; Godart, C.; Gronau, N.; Sharma, S.; Canals, G.

    2009-01-01

    Recent marketing and management literature has introduced the concept of co-creation of value. Current value modeling approaches such as e3-value focus on the exchange of value rather than co-creation. In this paper, an extension to e3-value is proposed in the form of a “value encounter”. Value

  15. Value encounters : Modelling and analyzing co-creation of value

    NARCIS (Netherlands)

    Weigand, H.; Jayasinghe Arachchig, J.

    2009-01-01

    Recent marketing and management literature has introduced the concept of co-creation of value. Current value modeling approaches such as e3-value focus on the exchange of value rather than co-creation. In this paper, an extension to e3-value is proposed in the form of a “value encounter”. Value

  16. Values in Time Discounting.

    Science.gov (United States)

    Heilmann, Conrad

    2017-10-01

    Controversies about time discounting loom large in decisions about climate change. Prominently, a particularly controversial debate about time discounting in climate change decision-making has been conducted within climate economics, between the authors of Stern et al. (Stern review on the economics of climate change, 2006) and their critics (most prominently Dasgupta in Comments on the Stern review's economics of climate change, 2006; Tol in Energy Environ 17(6):977-981, 2006; Weitzman in J Econ Lit XLV:703-724, 2007; Nordhaus in J Econ Lit XLV:686-702, 2007). The article examines the role of values in this debate. Firstly, it is shown that time discounting is a case in which values are key because it is at heart an ethical problem. Secondly, it is argued that time discounting in climate economics is a case of economists making frequent and routine references to ethical values and indeed conduct ethical debates with each other. Thirdly, it is argued that there is evidence for deep and pervasive entanglement between facts and values in the prevalent methodologies for time discounting. Finally, it is argued that this means that economists have given up the 'value-free ideal' concerning time discounting, and discussed how the current methodology of time discounting in economics can be improved.

  17. Multi-valued fields

    CERN Document Server

    Ershov, Yuri L

    2001-01-01

    For more than 30 years, the author has studied the model-theoretic aspects of the theory of valued fields and multi-valued fields. Many of the key results included in this book were obtained by the author whilst preparing the manuscript. Thus the unique overview of the theory, as developed in the book, has been previously unavailable. The book deals with the theory of valued fields and mutli-valued fields. The theory of Prüfer rings is discussed from the `geometric' point of view. The author shows that by introducing the Zariski topology on families of valuation rings, it is possible to distinguish two important subfamilies of Prüfer rings that correspond to Boolean and near Boolean families of valuation rings. Also, algebraic and model-theoretic properties of multi-valued fields with near Boolean families of valuation rings satisfying the local-global principle are studied. It is important that this principle is elementary, i.e., it can be expressed in the language of predicate calculus. The most important...

  18. Value of Fundamental Science

    Science.gov (United States)

    Burov, Alexey

    Fundamental science is a hard, long-term human adventure that has required high devotion and social support, especially significant in our epoch of Mega-science. The measure of this devotion and this support expresses the real value of the fundamental science in public opinion. Why does fundamental science have value? What determines its strength and what endangers it? The dominant answer is that the value of science arises out of curiosity and is supported by the technological progress. Is this really a good, astute answer? When trying to attract public support, we talk about the ``mystery of the universe''. Why do these words sound so attractive? What is implied by and what is incompatible with them? More than two centuries ago, Immanuel Kant asserted an inseparable entanglement between ethics and metaphysics. Thus, we may ask: which metaphysics supports the value of scientific cognition, and which does not? Should we continue to neglect the dependence of value of pure science on metaphysics? If not, how can this issue be addressed in the public outreach? Is the public alienated by one or another message coming from the face of science? What does it mean to be politically correct in this sort of discussion?

  19. SOURCES OF ENTERPRISE VALUE

    Directory of Open Access Journals (Sweden)

    Viorica Mădălina Ion

    2016-05-01

    Full Text Available The value of the enterprise has an increased importance in business valuation, so maximizing it becomes a priority for the interested parties, such as its shareholders or investors. The purpose of this article is the analysis of the sources of enterprise value and its factors, in order to understand the causes of the decrease or the possibilities for maximizing the enterprise value, passing over the main concepts in the literature. The analysis refers to the listed companies on the Bucharest Stock Exchange (BVB from the energy sector, including the largest Romanian company as per its capitalization, OMV Petrom. The research took into account the fact that the analysis of a large company with a long history is facilitated by the existence of multi-annual information, unlike the firms in the early life cycle operating in an emerging market.

  20. Earned value project management

    CERN Document Server

    Fleming, Quentin W

    2010-01-01

    Organizations that follow the principles of good Earned Value Management (EVM) create an environment that allows teams to successfully operate and thrive ? even in the face of challenges that could negatively impact their projects. Earned Value Project Management (EVPM) is a methodology used to measure and communicate the real physical progress of a project taking into account the work completed, the time taken and the costs incurred to complete that work. As a result, EVPM allows more educated and effective management decision-making, which helps evaluate and control project risk by measuring project progress in monetary terms. In the first two editions of Earned Value Project Management, Quentin W. Fleming and Joel M. Koppelman provided guidance for project management practitioners already familiar with EVPM, was well as those who were new to the use of this technique. The third edition expanded the information available on of EVPM for medium and smaller projects while still being relevant for larger projec...

  1. Value tree analysis

    International Nuclear Information System (INIS)

    Keeney, R.; Renn, O.; Winterfeldt, D. von; Kotte, U.

    1985-01-01

    What are the targets and criteria on which national energy policy should be based. What priorities should be set, and how can different social interests be matched. To answer these questions, a new instrument of decision theory is presented which has been applied with good results to controversial political issues in the USA. The new technique is known under the name of value tree analysis. Members of important West German organisations (BDI, VDI, RWE, the Catholic and Protestant Church, Deutscher Naturschutzring, and ecological research institutions) were asked about the goals of their organisations. These goals were then ordered systematically and arranged in a hierarchical tree structure. The value trees of different groups can be combined into a catalogue of social criteria of acceptability and policy assessment. The authors describe the philosophy and methodology of value tree analysis and give an outline of its application in the development of a socially acceptable energy policy. (orig.) [de

  2. Earned Value Management

    CERN Document Server

    Ferguson, J

    2002-01-01

    Earned Value Management is a methodology used to measure and communicate the real physical progress of a project and show its true cost situation. This tool was developed by the US Department of Defense in 1967 and later used successfully for monitoring DOE projects, in particular the US LHC accelerator project. A clear distinction must be made between an earned value management system and other tools under consideration or already existing at CERN which permit accurate predictions of the amount and date of future payments or a detailed follow up of contracts.

  3. Value and Momentum Everywhere

    DEFF Research Database (Denmark)

    Asness, Clifford S.; Moskowitz, Tobias J.; Heje Pedersen, Lasse

    across asset classes than passive exposures to the asset classes themselves. However, value and momentum are negatively correlated both within and across asset classes. Our results indicate the presence of common global risks that we characterize with a three factor model. Global funding liquidity risk...... is a partial source of these patterns, which are identifiable only when examining value and momentum simultaneously across markets. Our findings present a challenge to existing behavioral, institutional, and rational asset pricing theories that largely focus on U.S. equities....

  4. General Sentiment and Value

    DEFF Research Database (Denmark)

    Arvidsson, Adam; Etter, Michael; Colleoni, Elanor

    The aim of this paper is to deepen the understanding of the relationship between corporate reputation and financial value. Theories as the resource based view or the contractual view lie ground for the assumption of a linear positive correlation between reputation and financial performance. However......, existing empirical studies have provided conflicting results regarding the direction and strength of this relationship so far. In this paper we claim that the assumption of a direct linear correlation between corporate reputation and financial value misrepresents current financial practices...

  5. Creating value in refining

    International Nuclear Information System (INIS)

    Cobb, C.B.

    2001-01-01

    This article focuses on recent developments in the US refining industry and presents a model for improving the performance of refineries based on the analysis of the refining industry by Cap Gemini Ernst and Young. The identification of refineries in risk of failing, the construction of pipelines for refinery products from Gulf State refineries, mergers and acquisitions, and poor financial performance are discussed. Current challenges concerning the stagnant demand for refinery products, environmental regulations, and shareholder value are highlighted. The structure of the industry, the creation of value in refining, and the search for business models are examined. The top 25 US companies and US refining business groups are listed

  6. Values, Watersheds and Justification

    DEFF Research Database (Denmark)

    Wiberg, Katrina

    2015-01-01

    concerning HOW. Together, this also hold potentials of achieving multiple benefits and action promoting resilience and liveability in urban landscapes. One way of approaching the value disputes is by asking if some conception of the common good in case of HOW can be justified at the same time...... as the plurality and diversity of values are recognised. Luc Boltanski and Laurent Thévenot ́s concept of a plurality of regimes of justification -conflicting but also enabling compromise gives an affirmative answer to this question which is exemplified in the final parts of the paper....

  7. Leading Change, Adding Value.

    Science.gov (United States)

    Evans, Nick

    2016-09-12

    Essential facts Leading Change, Adding Value is NHS England's new nursing and midwifery framework. It is designed to build on Compassion in Practice (CiP), which was published 3 years ago and set out the 6Cs: compassion, care, commitment, courage, competence and communication. CiP established the values at the heart of nursing and midwifery, while the new framework sets out how staff can help transform the health and care sectors to meet the aims of the NHS England's Five Year Forward View.

  8. R-values

    International Nuclear Information System (INIS)

    Roberts, K.

    2009-01-01

    I'll try to keep this short and simple. R LANL = (beta cpm of X exp on system 'A')/ (beta cpm of 99 Mo exp on system 'A')/ (beta cpm of X on system 'A', from thermal on 235 U)/ (beta cpm of 99 Mo on system 'A', from thermal on 235 U). As I understand it, the above equation is the historical (as well as current) way of determining R-values using data from beta counting at LANL. The ratio in the denominator, a little 'r', is the 'baseline' or 'calibration' value for a specific beta detector. Over time, if the detector 'drifts' one would see a variation in this 'r' during a thermal calibration measurement. This baseline is what LANL likes to track to monitor specific detector performance - this is not relevant to LLNL where gamma detection is used for determining R-values. LANL states that uncertainty is only dependent upon the count statistics for the isotopes measured. If one tries to convert this to an atom basis, the uncertainties will increase due to the incorporation of the uncertainties in the nuclear data used to convert the cpm to atoms. LLNL switched to gamma detection methods in the 1970s thus replacing our beta counting effort. The equation below is how we have since determined R-values. The numerator ratios atom values of isotopes that are determined by measuring gamma cpm (usually? using several peaks per isotope) and then converting to particle decay in dpm using detector efficiency for each peak and the appropriate branch ratio for each gamma emission. Isotope decay is then converted to atoms using specific activity, mass or volume?, and Avogadro's number. The denominator is simply the ratio of published, cumulative fission product chain yields for isotopes produced in a thermal irradiation on 235U - values of England and Ryder are used by LLNL for the NTNF program. Uncertainties in LLNL R-values are dependent upon gamma counting statistics as well as the nuclear data for each isotope. R LLNL = (Atoms of X exp )/(Atoms of 99 Mo exp )/(Cumulative

  9. Antiproliferative activity of some novel platinum complexes on C6 ...

    African Journals Online (AJOL)

    MCF-7) and glioma cells (C6). IC50 values of the three compounds were lower in the cisplatin-resistant cell type C6 cell lines than in MCF-7 cells. Key words: Cisplatin, antiproliferative activity, breast cancer cells (MCF-7), glioma cells (C6), IC50.

  10. Implementing Target Value Design.

    Science.gov (United States)

    Alves, Thais da C L; Lichtig, Will; Rybkowski, Zofia K

    2017-04-01

    An alternative to the traditional way of designing projects is the process of target value design (TVD), which takes different departure points to start the design process. The TVD process starts with the client defining an allowable cost that needs to be met by the design and construction teams. An expected cost in the TVD process is defined through multiple interactions between multiple stakeholders who define wishes and others who define ways of achieving these wishes. Finally, a target cost is defined based on the expected profit the design and construction teams are expecting to make. TVD follows a series of continuous improvement efforts aimed at reaching the desired goals for the project and its associated target value cost. The process takes advantage of rapid cycles of suggestions, analyses, and implementation that starts with the definition of value for the client. In the traditional design process, the goal is to identify user preferences and find solutions that meet the needs of the client's expressed preferences. In the lean design process, the goal is to educate users about their values and advocate for a better facility over the long run; this way owners can help contractors and designers to identify better solutions. This article aims to inform the healthcare community about tools and techniques commonly used during the TVD process and how they can be used to educate and support project participants in developing better solutions to meet their needs now as well as in the future.

  11. Value and Momentum Everywhere

    DEFF Research Database (Denmark)

    Asness, Clifford S.; Moskowitz, Tobias; Heje Pedersen, Lasse

    2013-01-01

    are negatively correlated with each other, both within and across asset classes. Our results indicate the presence of common global risks that we characterize with a three-factor model. Global funding liquidity risk is a partial source of these patterns, which are identifiable only when examining value...

  12. Valuing the Accreditation Process

    Science.gov (United States)

    Bahr, Maria

    2018-01-01

    The value of the National Association for Developmental Education (NADE) accreditation process is far-reaching. Not only do students and programs benefit from the process, but also the entire institution. Through data collection of student performance, analysis, and resulting action plans, faculty and administrators can work cohesively towards…

  13. Global Value Chain Configuration

    DEFF Research Database (Denmark)

    Hernandez, Virginia; Pedersen, Torben

    2017-01-01

    modes chosen and the different ways of coordinating them. We also examine the outcomes of a global value chain configuration in terms of performance and upgrading. Our aim is to review the state of the art of these issues, identify research gaps and suggest new lines for future research that would...

  14. Fighting over water values

    NARCIS (Netherlands)

    Mena-Vásconez, Patricio; Vincent, Linden; Vos, Jeroen; Boelens, Rutgerd

    2017-01-01

    Water management studies often overlook community diversity, different stakeholders’ values, and frames to claim water rights. Using a political-ecology approach, this article examines an irrigation system in Ecuador’s highlands via Fraser’s principles of justice (recognition, representation,

  15. Technostress and Library Values.

    Science.gov (United States)

    Gorman, Michael

    2001-01-01

    Discusses information overload and society's and libraries' responses to technology. Considers eight values that libraries should focus on and how they relate to technology in libraries: democracy, stewardship, service, intellectual freedom, privacy, rationalism, equity of access, and building harmony and balance. (LRW)

  16. Materialistic Values and Goals.

    Science.gov (United States)

    Kasser, Tim

    2016-01-01

    Materialism comprises a set of values and goals focused on wealth, possessions, image, and status. These aims are a fundamental aspect of the human value/goal system, standing in relative conflict with aims concerning the well-being of others, as well as one's own personal and spiritual growth. Substantial evidence shows that people who place a relatively high priority on materialistic values/goals consume more products and incur more debt, have lower-quality interpersonal relationships, act in more ecologically destructive ways, have adverse work and educational motivation, and report lower personal and physical well-being. Experimentally activating materialistic aims causes similar outcomes. Given these ills, researchers have investigated means of decreasing people's materialism. Successful interventions encourage intrinsic/self-transcendent values/goals, increase felt personal security, and/or block materialistic messages from the environment. These interventions would likely be more effective if policies were also adopted that diminished contemporary culture's focus on consumption, profit, and economic growth.

  17. The value (driven) web

    NARCIS (Netherlands)

    Baken, N.H.G.; Wiegel, V.; Van Oortmerssen, G.

    2010-01-01

    This paper presents a vision on the importance of values and ethical aspects in web science. We create(d) the Internet, but now the Internet (technology) is shaping our world increasingly: the way we experience, interact, transact, conduct business et cetera. The Internet is ubiquitous and vital to

  18. Value reflected health education

    DEFF Research Database (Denmark)

    Wistoft, Karen; Nordentoft, Helle Merete

    2011-01-01

    This article examines the impact of a value-reflected approach in health education by demonstrating the nature of professional competence development connected to this approach. It is based on findings from two three-year health educational development projects carried out by school health nurses...... develop pedagogical competences in health education improving school childrens’ health....

  19. The hidden values

    DEFF Research Database (Denmark)

    Rasmussen, Birgitte; Jensen, Karsten Klint

    “The Hidden Values - Transparency in Decision-Making Processes Dealing with Hazardous Activities”. The report seeks to shed light on what is needed to create a transparent framework for political and administrative decisions on the use of GMOs and chemical products. It is our hope that the report...

  20. The role of values

    NARCIS (Netherlands)

    Pigmans, K.A.M.; Aldewereld, Huib; Dignum, V; Doorn, N.

    2017-01-01

    Decision-making processes involving multiple stakeholders can be rather cumbersome, turbulent and lengthy. The stance of some stakeholders, upholding their individual interests, can slowdown or even block such processes. Recent research suggests that a focus on the values of the stakeholders could

  1. Value oriented marketing strategies

    Directory of Open Access Journals (Sweden)

    Stanković Ljiljana

    2009-01-01

    Full Text Available The complexity of business environment imposes the need for continuous change and reexamination of business marketing strategies of enterprises. Theory and practice of strategic management and marketing show that the activities of marketing, which are closely connected to corporate strategy, are the key drivers of growth. There is a positive correlation between competition intensity, marketing strategy and business performance of companies. Even though, managers of many companies don't see a clear connection between marketing strategy and business performance, numerous empirical research show that the companies which possess and efficiently use marketing resources and capabilities are more successful. In knowledge-based economics, the development of value oriented marketing strategies for all participants in the chain is a supposition of the survival, growth and development of companies. Competitive advantage is the essence of any strategy. Acquisition and maintenance of competitive advantage is more successful if the potentials for value creation are used efficiently. The paper examines the critical factors that influence alignment and transformation of marketing strategies in accordance with changes in value estimation. Superior value, is created in different network classes. Theory and practice researches create a reliable basis for the development of new concepts, marketing strategy business models that will contribute to competitive advantage of enterprises and the economy.

  2. Single Value Devices

    NARCIS (Netherlands)

    Mader, Angelika H.; Dertien, Edwin Christian; Reidsma, Dennis

    2011-01-01

    We live in a world of continuous information overflow, but the quality of information and communication is suffering. Single value devices contribute to the information and communication quality by fo- cussing on one explicit, relevant piece of information. The information is decoupled from a

  3. Researching Values in Education.

    Science.gov (United States)

    Halliday, John

    2002-01-01

    Considers methodological issues that arise when values form the main focus of empirical educational research. Includes discussion of the idea that social science, in general, and educational research, in particular, are forms of moral inquiry. Outlines a methodology of educational research, drawing from work by Imre Lakatos, Alasdair MacIntyre,…

  4. Radiology's value chain.

    Science.gov (United States)

    Enzmann, Dieter R

    2012-04-01

    A diagnostic radiology value chain is constructed to define its main components, all of which are vulnerable to change, because digitization has caused disaggregation of the chain. Some components afford opportunities to improve productivity, some add value, while some face outsourcing to lower labor cost and to information technology substitutes, raising commoditization risks. Digital image information, because it can be competitive at smaller economies of scale, allows faster, differential rates of technological innovation of components, initiating a centralization-to-decentralization technology trend. Digitization, having triggered disaggregation of radiology's professional service model, may soon usher in an information business model. This means moving from a mind-set of "reading images" to an orientation of creating and organizing information for greater accuracy, faster speed, and lower cost in medical decision making. Information businesses view value chain investments differently than do small professional services. In the former model, producing a better business product will extend image interpretation beyond a radiologist's personal fund of knowledge to encompass expanding external imaging databases. A follow-on expansion with integration of image and molecular information into a report will offer new value in medical decision making. Improved interpretation plus new integration will enrich and diversify radiology's key service products, the report and consultation. A more robust, information-rich report derived from a "systems" and "computational" radiology approach will be facilitated by a transition from a professional service to an information business. Under health care reform, radiology will transition its emphasis from volume to greater value. Radiology's future brightens with the adoption of a philosophy of offering information rather than "reads" for decision making. Staunchly defending the status quo via turf wars is unlikely to constitute a

  5. Value, utility and needs

    DEFF Research Database (Denmark)

    Ravn, Ib

    Positive Psychology and Self-Determination Theory (SDT, Deci & Ryan, 2000) share an ambition to identify the sources of value and human flourishing. In the 19th century, the emerging science of economics similarly investigated the nature of social value in a capitalist society that placed a price...... in SDT have gathered extensive evidence that needs for autonomy, competence and relatedness must be met for human flourishing and eudaimonia to occur (Ryan, Huta and Deci, 2013). There is a short step to arguing that what is valuable in life is what satisfies human needs. As has been established by SDT...... on every commodity. In this conceptual paper, SDTs’ mini-theory of Basic Psychological Needs is applied to solve the “paradox of value” in economics (Weisskopf, 1956): Why are some things that are practically free, such as oxygen, water and fellowship, so valuable to people, while others, often craved...

  6. THE VALUE OF CREATIVITY

    DEFF Research Database (Denmark)

    Hertel, Frederik

    2016-01-01

    Previous analysis (Hertel, 2015) indicates that workers doing industrial cleaning in the food industry are forced to be creative in their everyday organizational life. There is (e.g. Richards, 2010) a lack of scientific methods for valuing such everyday creativity. The main question we want...... to address in this conference paper is: how can we not only understand but also evaluate creativity produced in organizations e.g. industrial cleaners? We will conduct a new case analysis in order to clarify whether such creativity can be compared with and understood as a new kind of (cf. Portes, 1998...... & Bourdieu, 1990 & 2002) symbolic capital. In case creativity actually can be regarded a symbolic capital we will discuss methods for valuing such a capital produced by creative industrial cleaners during their work at night....

  7. Improving University Research Value

    Directory of Open Access Journals (Sweden)

    Kelley O’Reilly

    2012-07-01

    Full Text Available This article investigates the current data management practices of university researchers at an Intermountain West land-grant research university in the United States. Key findings suggest that researchers are primarily focused on the collection and housing of research data. However, additional research value exists within the other life cycle stages for research data—specifically in the stages of delivery and maintenance. These stages are where most new demands and requirements exist for data management plans and policies that are conditional for external grant funding; therefore, these findings expose a “gap” in current research practice. These findings should be of interest to academics and practitioners alike as findings highlight key management gaps in the life cycle of research data. This study also suggests a course of action for academic institutions to coalesce campus-wide assets to assist researchers in improving research value.

  8. Cultural War of Values

    DEFF Research Database (Denmark)

    Hervik, Peter

    2014-01-01

    Cultural War of Values: The Proliferation of Moral Identities In the Danish Public Sphere Peter Hervik (Aalborg University) This chapter looks at the drastic shift in the construction of minority others that came with the emergence of neo-nationalism, neo-racism and radical right populism...... in the post-1989 world. Through an analysis of a political philosophy launched in Denmark in the 1990s called the “Cultural War of Values”, I show that the moral identities proliferating in the Danish public sphere are fundamentally anti-political correct, anti-multiculturalist, and anti......-Marxist as confrontation is also directed at political adversaries. Thus, the chapter’s key argument is that the social construction of thick minority identities can only be understood in relation to the cultural war of value strategy aimed at domestic political opponents....

  9. The Value of Culture

    DEFF Research Database (Denmark)

    Skrede, Joar

    2014-01-01

    House has already been built. Parallel to this project, a decision has been made to relocate several old museums without any plans for the existing premises. Both projects have triggered years of debate in the media and the general public, and many of the decisions are highly disputed. From the official......, and that economic motives are given more attention than culture itself. This may be understood as a neoliberalisation of values where spheres of social and cultural life are subjected to the logic of the market....... documents and the public debate, it is evident that “culture” is vital in the urban development projects, but it is ambiguous what the value of “culture” consists of. Many citizens are questioning the disruption to historical continuity and they are confused about the political reasoning behind...

  10. Best value for money

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    Last week, the Industrial Services and General Infrastructure section of the Procurement and Industrial Services group received dozens of bids in a single day! The bids were submitted in response to four invitations to tender to be adjudicated on a ‘best value for money’ basis. This adjudication method, introduced at CERN in 2008, ensures that quality is given as much priority as cost containment in the process of awarding industrial services contracts.   Members of the Industrial Services and General Infrastructure section with the dozens of bids received in a single day. Until 2008 every contract at CERN was adjudicated on a "lowest compliant bid" basis, i.e. to the firm submitting the cheapest technically compliant tender. Since then, however, the CERN Financial Rules, including the Procurement Rules, have undergone an in-depth revision, and the ‘best value for money’ adjudication basis has been introduced. According to the new adju...

  11. Contingencies of Value

    DEFF Research Database (Denmark)

    Strandvad, Sara Malou

    2014-01-01

    Based on a study of the admission test at a design school, this paper investigates the contingencies of aesthetic values as these become visible in assessment practices. Theoretically, the paper takes its starting point in Herrnstein Smith’s notion of ‘contingencies of values’ and outlines...... a pragmatist ground where cultural sociology and economic sociology meet. Informed by the literature on cultural intermediaries, the paper discusses the role of evaluators and the devices which accompany them. Whereas studies of cultural intermediaries traditionally apply a Bourdieusian perspective, recent......, the paper does not accept this storyline. As an alternative, the paper outlines the contingencies of values which are at play at the admission test, composed of official assessment criteria and scoring devices together with conventions within the world of design, and set in motion by interactions...

  12. Education: A Core Value

    Science.gov (United States)

    Carroll, William F., Jr.

    2001-09-01

    Teaching our Children. ACS should develop an intensive course in modern teaching methods, challenges and responsibilities, and press for streamlined teacher certification procedures for advanced degree or life experience chemists. Teaching our Future Colleagues. As President I will encourage companies to make scientists with special skills available to universities, and will encourage universities to utilize these scientists to round out areas of study not covered by their existing faculty. Teaching our Members. ACS should develop functional and management-related courses for scientists to facilitate career advancement from the bench to research management or from science to business. Teaching the Public. The President is the most visible representative of the Society, and should devote significant time to communication with lay audiences. Value Matters. My first priority as President will be to increase value creation, communication and quantification so members can easily identify programs that fill their needs and exceed their expectations.

  13. How Airbnb Creates Value

    OpenAIRE

    Reinhold, Stephan; Dolnicar, Sara

    2017-01-01

    A business model is like an ultrasound for businesses: it provides – from the outside – detailed insight into six vital elements of a business which explain their functioning (Chapter 3). Each peer-to-peer accommodation network is slightly different and requires an independent business model analysis. Here we analyse the business model of Airbnb because it is the international market leader in peer-to-peer accommodation trading and a model other platforms aspire to. We focus on value proposit...

  14. Value of risk management

    OpenAIRE

    Vik, Marie Amdal

    2012-01-01

    Master's thesis in Risk management The overall aim of this study was to discuss the validity of the hypothesis that risk management contributes with added value to projects and the enterprise holding the projects, and consequently to the enterprise’s stakeholders. To examine this hypothesis, a case study of three projects taken from the same portfolio at Statoil was selected. The projects were said to have an active risk management. Data was collected from the project’s documentation as...

  15. Unaustralia: Strangeness and Value

    Directory of Open Access Journals (Sweden)

    John Frow

    2011-05-01

    Full Text Available This essay explores the flawed legal regime governing national security in Australia. It focuses on legislation related to anti-terrorism and discusses the negative effects of the bills, particularly in relation to the treatment of refugees and asylum seekers. The author reflects on the harsh political and social climate of Australia during the era of the Howard government and One Nation party, noting that democratic and the liberal values can be in conflict.

  16. The value of biodiversity

    Directory of Open Access Journals (Sweden)

    CJR. Alho

    Full Text Available In addition to its intrinsic value (nature working as it is; species are the product of a long history of continuing evolution by means of ecological processes, and so they have the right to continued existence, biodiversity also plays a fundamental role as ecosystem services in the maintenance of natural ecological processes. The economic or utilitarian values of biodiversity rely upon the dependence of man on biodiversity; products that nature can provide: wood, food, fibers to make paper, resins, chemical organic products, genes as well as knowledge for biotechnology, including medicine and cosmetic sub-products. It also encompasses ecosystem services, such as climate regulation, reproductive and feeding habitats for commercial fish, some organisms that can create soil fertility through complex cycles and interactions, such as earthworms, termites and bacteria, in addition to fungi responsible for cycling nutrients like nitrogen, phosphorus and sulfur and making them available to plant absorption. These services are the benefits that people indirectly receive from natural ecosystem functions (air quality maintenance, regional climate, water quality, nutrient cycling, reproductive habitats of commercial fish, etc. with their related economic values.

  17. Teaching and values education

    Directory of Open Access Journals (Sweden)

    Azucena Ochoa Cervantes

    2012-11-01

    Full Text Available Our social context suffers profound gaps that have to interact with the ethical dimension. Education is regarded as a one of the basic tools to overcome these shortcomings. Based of the before premise, there was conducted an reserach with 50 teachers from primary level of the city of Querétaro (Mexico. The aim consist on to know if carrying out education in values, the purpose pursued with these themes working thereon and assessment situations generated for that purpose. The result shows that teachers say they are working on values education. However, there is some inconsistency between the purpose pursuing that claim and the efforts to achieve this. The above said implies that the fact of to tray to implement curricular changes, it not necessarily has an impact on the construction of new practices to improve educational processes. It seems that the results of this work can be useful for policy makers of the educational management, it’s because it is necessary to make training in teachers, covering not only the conceptual formation, but also the individual and the process to make values. This should be included as part of the deontological and professional development of teachers

  18. Generic clearance values

    International Nuclear Information System (INIS)

    Bossio, M.C.; Muniz, C.C.

    2009-01-01

    This paper analyzes the Generic Clearance Values established for natural and artificial radionuclides with the objective of evaluating their degree of conservatism in views of adopting them into the regulatory body. Generic clearance values for natural radionuclides have been chosen by experts judgments as the optimum boundary between, on one hand, the ubiquitous unmodified soil concentrations and, on the other hand, activity concentrations in ores, mineral sands, industrial residues and wastes. For artificial radionuclides the clearance levels have been derived from the scenarios postulated in the document 'Safety Reports Series Nr 44' of the IAEA considering quantitative exemption criteria. A set of 8 scenarios were postulated covering external, ingestion and inhalation exposure pathways. For each radionuclide, the generic clearance level was derived as the more restrictive value obtained from the scenarios, that is the lowest ratio between the applicable individual dose and the dose per unit activity concentration (Bq/g). The individual dose was calculated by a formula depending on each scenario and pathway, with different parameters, such as exposure time, dosimetric factors, dilution factor, density of the material, geometric factors, etc. It was concluded that the basis and parameters used for the derivation of the generic clearance levels are quite conservative and therefore its the adoption in Argentina has been recommended. It is expected that their implementation will contribute to optimize the regulatory management system. (author)

  19. Generic Clearance Values

    International Nuclear Information System (INIS)

    Bossio, M.C.; Muniz, C.C.

    2010-01-01

    This paper analyzes the Generic Clearance Values established for natural and artificial radionuclides with the objective of evaluating their degree of conservatism in views of adopting them into the regulatory body. Generic clearance values for natural radionuclides have been chosen by experts judgments as the optimum boundary between, on the one hand, the ubiquitous unmodified soil concentrations and, on the other hand, activity concentrations in ores, mineral sands, industrial residues and wastes. For artificial radionuclides the clearance levels have been derived from the scenarios postulated in the document Safety Reports Series 44 of the IAEA considering quantitative exemption criteria. A set of 8 scenarios were postulated covering external, ingestion and inhalation exposure pathways. For each radionuclide, the generic clearance level was derived as the more restrictive value obtained from the scenarios, that is the lowest ratio between the applicable individual dose and the dose per unit activity concentration (Bq/g). The individual dose was calculated by a formula depending on each scenario and pathway, with different parameters, such as exposure time, dosimetric factors, dilution factor, density of the material, geometric factors, etc. It was concluded that the basis and parameters used for the derivation of the generic clearance levels are quite conservative and therefore its the adoption in Argentina has been recommended. It is expected that their implementation will contribute to optimize the regulatory management system. (authors) [es

  20. Management Resource Values

    Directory of Open Access Journals (Sweden)

    A. B. Bakuradze

    2013-01-01

    Full Text Available The paper looks at the managerial resource values guaranteeing the effective functioning and development of any social institution. The main emphasis is on the asset management in educational sphere and optimizationopportunities of organizational processes. The human, logistical, technical, informational and time resources ofmanagerial activity are outlined and specified from the strategic perspective and effectiveness standpoint. The necessary criteria of a strategic resource are identified as the value, rarity, originality and indispensability. The author makes a conclusion about the priority of human resources in the value hierarchy of social organization in the era of information society. The paper demonstrates both the theoretical and practical ways and means of raising the effectiveness and efficiency of educational institutions, as well as the constant need for teacher’s training, retraining, and stimulation of self-education. The investment in human resources and motivating environment, aimed at developing the potential of academic staff and other employees of educational institutions, benefits both the managers and employees alike and leads to social partnership, harmony, and conciliation of economic and social interests within the organization.

  1. Value-based genomics.

    Science.gov (United States)

    Gong, Jun; Pan, Kathy; Fakih, Marwan; Pal, Sumanta; Salgia, Ravi

    2018-03-20

    Advancements in next-generation sequencing have greatly enhanced the development of biomarker-driven cancer therapies. The affordability and availability of next-generation sequencers have allowed for the commercialization of next-generation sequencing platforms that have found widespread use for clinical-decision making and research purposes. Despite the greater availability of tumor molecular profiling by next-generation sequencing at our doorsteps, the achievement of value-based care, or improving patient outcomes while reducing overall costs or risks, in the era of precision oncology remains a looming challenge. In this review, we highlight available data through a pre-established and conceptualized framework for evaluating value-based medicine to assess the cost (efficiency), clinical benefit (effectiveness), and toxicity (safety) of genomic profiling in cancer care. We also provide perspectives on future directions of next-generation sequencing from targeted panels to whole-exome or whole-genome sequencing and describe potential strategies needed to attain value-based genomics.

  2. Value Encounters - Modeling and Analyzing Co-creation of Value

    Science.gov (United States)

    Weigand, Hans

    Recent marketing and management literature has introduced the concept of co-creation of value. Current value modeling approaches such as e3-value focus on the exchange of value rather than co-creation. In this paper, an extension to e3-value is proposed in the form of a “value encounter”. Value encounters are defined as interaction spaces where a group of actors meet and derive value by each one bringing in some of its own resources. They can be analyzed from multiple strategic perspectives, including knowledge management, social network management and operational management. Value encounter modeling can be instrumental in the context of service analysis and design.

  3. Values and behaviour model

    International Nuclear Information System (INIS)

    Anon

    2011-01-01

    Occupational injuries, accidents, trips of equipment, emergencies, and idle times represent a loss from each megawatt hour which we could have supplied to the network, or other costs related to settlement or compensation for damages. All of it can be caused by short lack of attention while doing a routine job, ignoring safety indicators, and rules. Such behaviour would not be a characteristic of a professional. People working at the nuclear power plants are the first ones to learn about the Values and Behaviour Model. (author)

  4. Community Solar Value Project

    Energy Technology Data Exchange (ETDEWEB)

    Powers, John T [Extensible Energy; Cliburn, Jill [Cliburn and Associates

    2017-11-30

    The Community Solar Value Project (CSVP) is designed to assist electric utilities in designing better community solar programs. Better programs seek new sources of value to promote “win-win” solutions between utilities and their customers. The CSVP focused on five “challenge areas” in identifying new sources of value: - Strategic solar design for community solar projects (including technology choices, siting, orientation, and related issues) - Market research and targeted marketing approaches (for program design and for customer recruitment) - Procurement and financing (for establishing best practices that can bring economies of scale and economies of expertise) - Integration of “companion measures” (such as storage and demand-response options that can benefit customer and utility net load shapes) - Pricing in program design (including best practices for integration of identified value in program prices or credits) The CSVP directly engaged the Sacramento Municipal Utility District (SMUD), the Public Service Company of New Mexico (PNM), and more than a dozen other utilities to develop improved community solar program designs. The outcomes include a plan at SMUD for over 100 MW or more of community and shared solar and support for new or expanded programs at 15 other utilities so far. Resulting best-practice solutions have not only informed program applications, but also have generated discussion among experts and industry associations about the new opportunities and challenges CSVP has brought forth. In these ways, the CSVP has impacted community solar programs and DER plans, competitive innovations and policies nationwide. The CSVP team has been led by Extensible Energy under John Powers, President and CEO. Jill Cliburn, of Santa Fe, NM-based Cliburn and Associates, has served as Principal Investigator. The team also benefitted from expertise from Navigant, Olivine Inc. and Millennium Energy, LLC, in addition to the collaborative and cost

  5. Value of information

    DEFF Research Database (Denmark)

    Straub, D.; Chatzi, E.; Bismut, E.

    2017-01-01

    The concept of value of information (VoI) enables quantification of the benefits provided by structural health monitoring (SHM) systems –in principle. Its implementation is challenging, as it requires an explicit modelling of the structural system’s life cycle, in particular of the decisions...... that are taken based on the SHM information. In this paper, we approach the VoI analysis through an influence diagram (ID), which supports the modelling process. We provide a simple example for illustration and discuss challenges associated with real-life implementation...

  6. The value of reliability

    DEFF Research Database (Denmark)

    Fosgerau, Mogens; Karlström, Anders

    2010-01-01

    We derive the value of reliability in the scheduling of an activity of random duration, such as travel under congested conditions. Using a simple formulation of scheduling utility, we show that the maximal expected utility is linear in the mean and standard deviation of trip duration, regardless...... of the form of the standardised distribution of trip durations. This insight provides a unification of the scheduling model and models that include the standard deviation of trip duration directly as an argument in the cost or utility function. The results generalise approximately to the case where the mean...

  7. The value of diversity

    International Nuclear Information System (INIS)

    Jones, P.M.S.

    1994-01-01

    Although the adoption of a range of fuels employing different technologies incurs extra cost, diversity can provide a measure of security against supply disruption, fuel price escalation and environmental regulatory changes. Attempts to set a value to diversity in the United Kingdom are reviewed. Most of these have explored the economic impact of different mixes of fuels and/or technologies against a series of postulated fuel price and energy demand scenarios. They depend on the reliability of the cost and technical performance inputs, and subjective judgements about future price and demand developments; these factors undermine confidence in quantitative outputs of such methods. The novel approach of Stirling is presented. This seeks to derive an optimum plant/fuel mix using generation costs for a wide range of options and a marginal value for incremental changes in diversity, based on a specified diversity index. Stirling's approach could be argued to support the maintenance or expansion of the existing nuclear component of United Kingdom power supplies and an increase in the contribution from renewables. However, problems within the method which is still under development limits the weight that can be attached to its findings at present. Given the closely comparable financial costs, a reasonable balance at this time would seem to consist of the available level of low cost renewables and roughly equal tranches of gas, nuclear and coal. A smaller coal-fired component would be appropriate if environmental costs are taken into account. (19 references). (UK)

  8. Facts, values, and journalism.

    Science.gov (United States)

    Gilbert, Susan

    2017-03-01

    At a time of fake news, hacks, leaks, and unverified reports, many people are unsure whom to believe. How can we communicate in ways that make individuals question their assumptions and learn? My colleagues at The Hastings Center and many journalists and scientists are grappling with this question and have, independently, reached the same first step: recognize that facts can't be fully understood without probing their connection to values. "Explaining the basics is important, of course, but we also need to diversify our approach to the coverage of science-particularly as it intersects with the matrix of cultural, religious, social, and political values of our readers," said an article in Undark, an online magazine of science journalism. An editorial in Nature called for scientists to engage directly with citizens in debates over climate change and genome editing, noting that "the ethical issues can be critically dependent on the science, for example, in understanding where the boundaries between non-heritable and heritable genome modifications might be." We're here to help. © 2017 The Hastings Center.

  9. Higher Education and Ethical Value

    Science.gov (United States)

    Lee, Jeong-Kyu

    2017-01-01

    The purpose of this study is to explore the importance of ethical value in higher education as well as the relevance between ethical value and higher education. In order to examine the study logically, three research questions are addressed: First, what is value, ethical value, and Asiatic ethical value? Second, for whom and what is higher…

  10. Personal Values in HCI Research

    OpenAIRE

    Sas, Corina

    2017-01-01

    This paper describes a broad overview of the core values underpinning my research agenda for more than a decade. It draws from value research, research values, and values in HCI, and concludes with some insights on the challenges and opportunities of developing a value-driven personal research agenda.

  11. The value of renewables

    International Nuclear Information System (INIS)

    Koch, H.J.

    2001-01-01

    The article extols the virtues of renewable energy sources. Based largely on the outcome of an IAE meeting in May 2001, the author has outlined an approach for accelerating the development of renewables. The article quotes several statements made by the IAE with respect to the need for a secure supply of affordable energy, sustainable development, diversification, the value of renewables and challenges confronting developers of renewables. The article is presented under the sub-headings of: (i) harnessing energy market forces; (ii) understanding costs in the context of diversification; (iii) economic performance; (iv) environmental protection; (v) an IAE action plan and (vi) conclusions. The author was once the IAE's director for energy efficiency, technology and R and D

  12. Network connectivity value.

    Science.gov (United States)

    Dragicevic, Arnaud; Boulanger, Vincent; Bruciamacchie, Max; Chauchard, Sandrine; Dupouey, Jean-Luc; Stenger, Anne

    2017-04-21

    In order to unveil the value of network connectivity, we formalize the construction of ecological networks in forest environments as an optimal control dynamic graph-theoretic problem. The network is based on a set of bioreserves and patches linked by ecological corridors. The node dynamics, built upon the consensus protocol, form a time evolutive Mahalanobis distance weighted by the opportunity costs of timber production. We consider a case of complete graph, where the ecological network is fully connected, and a case of incomplete graph, where the ecological network is partially connected. The results show that the network equilibrium depends on the size of the reception zone, while the network connectivity depends on the environmental compatibility between the ecological areas. Through shadow prices, we find that securing connectivity in partially connected networks is more expensive than in fully connected networks, but should be undertaken when the opportunity costs are significant. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Enhancing customer value

    International Nuclear Information System (INIS)

    Gabel, B.

    1996-01-01

    A discussion on how Westcoast Gas Services Inc., is striving to meet customer satisfaction was presented. A strategic business unit called storage, transportation and service is a customer-centered, energy service enterprise dedicated to providing value-added service. The company is placing emphasis on better coordination of sales and marketing activities, especially in areas of customer relationship management and product development. Deregulation was responsible for the changing marketplace. It resulted in increased competition, energy alliances and multi-fuel opportunities. Some of the ways Westcoast Gas Service plans to survive and prosper in this new world of competition were outlined. Among the ideas mentioned were consumer orientation, superior information about consumers and competitors, quick adaptation to changing market conditions, anticipation of consumer needs, and appropriate product development

  14. Globalization, values, interests

    Directory of Open Access Journals (Sweden)

    Radojičić Mirjana S.

    2003-01-01

    Full Text Available The nature of the international politics, after the Cold War directed by the U.S. as the only current super-power, are considered in the text. The author’s intention is to stress the main points of divergence between moralistic-valuable rhetoric and the foreign policy practice of the U.S. In that sense, the examples of the American stand, i.e. the active treatment of the Yugoslav crisis, on the one hand, and the crisis in the Persian Gulf, on the other hand, is considered. The author’s conclusion is that the foreign policy of the only current super-power is still directed by interests rather then by values. In the concluding part, the author presents an anthropologic argument in favor of reestablishing "balance of power" as the only guarantee for peace and stability of the world.

  15. Values in the trash

    DEFF Research Database (Denmark)

    Gjerris, Mickey; Gaiani, S.

    2015-01-01

    and is one of the important contributors to climate change, simply seems wrong. Here we discuss three questions in relation of this almost self-evident fact: (1) different definitions of food waste and the difficulties in reaching a global definition, how desirable it might be; (2) different ways......Food waste is one of the most discussed subjects within food production in recent years. Throwing food away at a time when almost 900 million humans live in hunger and it is becoming more and more clear that food production draws on limited resources of eg. agricultural land and fresh water...... of preventing food waste from the individual to the international level and the importance of examining the values behind different strategies; and (3) ethical challenges in relation to food waste and the opportunity to utilize the indignation that many feel when confronted with food waste to re...

  16. The innovation value chain.

    Science.gov (United States)

    Hansen, Morten T; Birkinshaw, Julian

    2007-06-01

    The challenges of coming up with fresh ideas and realizing profits from them are different for every company. One firm may excel at finding good ideas but may have weak systems for bringing them to market. Another organization may have a terrific process for funding and rolling out new products and services but a shortage of concepts to develop. In this article, Hansen and Birkinshaw caution executives against using the latest and greatest innovation approaches and tools without understanding the unique deficiencies in their companies' innovation systems. They offer a framework for evaluating innovation performance: the innovation value chain. It comprises the three main phases of innovation (idea generation, conversion, and diffusion) as well as the critical activities performed during those phases (looking for ideas inside your unit; looking for them in other units; looking for them externally; selecting ideas; funding them; and promoting and spreading ideas companywide). Using this framework, managers get an end-to-end view of their innovation efforts. They can pinpoint their weakest links and tailor innovation best practices appropriately to strengthen those links. Companies typically succumb to one of three broad "weakest-link" scenarios. They are idea poor, conversion poor, or diffusion poor. The article looks at the ways smart companies - including Intuit, P&G, Sara Lee, Shell, and Siemens- modify the best innovation practices and apply them to address those organizations' individual needs and flaws. The authors warn that adopting the chain-based view of innovation requires new measures of what can be delivered by each link in the chain. The approach also entails new roles for employees "external scouts" and "internal evangelists," for example. Indeed, in their search for new hires, companies should seek out those candidates who can help address particular weaknesses in the innovation value chain.

  17. Health Care Provider Value Chain

    OpenAIRE

    Kawczynski , Lukasz; Taisch , Marco

    2009-01-01

    International audience; In every society there is a need for an efficient health care system. This paper aims to propose a value definition and a value chain model within the health care. In order to define value patients and experts were surveyed. The proposed definition offers a complex way of looking at the value within the health care sector. The proposal of the value chain model is anticipated with a value stream mapping activities and experts interviews. Proposed model offers consistent...

  18. The forecaster's added value

    Science.gov (United States)

    Turco, M.; Milelli, M.

    2009-09-01

    To the authors' knowledge there are relatively few studies that try to answer this topic: "Are humans able to add value to computer-generated forecasts and warnings ?". Moreover, the answers are not always positive. In particular some postprocessing method is competitive or superior to human forecast (see for instance Baars et al., 2005, Charba et al., 2002, Doswell C., 2003, Roebber et al., 1996, Sanders F., 1986). Within the alert system of ARPA Piemonte it is possible to study in an objective manner if the human forecaster is able to add value with respect to computer-generated forecasts. Every day the meteorology group of the Centro Funzionale of Regione Piemonte produces the HQPF (Human QPF) in terms of an areal average for each of the 13 regional warning areas, which have been created according to meteo-hydrological criteria. This allows the decision makers to produce an evaluation of the expected effects by comparing these HQPFs with predefined rainfall thresholds. Another important ingredient in this study is the very dense non-GTS network of rain gauges available that makes possible a high resolution verification. In this context the most useful verification approach is the measure of the QPF and HQPF skills by first converting precipitation expressed as continuous amounts into ‘‘exceedance'' categories (yes-no statements indicating whether precipitation equals or exceeds selected thresholds) and then computing the performances for each threshold. In particular in this work we compare the performances of the latest three years of QPF derived from two meteorological models COSMO-I7 (the Italian version of the COSMO Model, a mesoscale model developed in the framework of the COSMO Consortium) and IFS (the ECMWF global model) with the HQPF. In this analysis it is possible to introduce the hypothesis test developed by Hamill (1999), in which a confidence interval is calculated with the bootstrap method in order to establish the real difference between the

  19. Adding Production Value Through Application of Value Based Scheduling

    DEFF Research Database (Denmark)

    Lindhard, Søren; Wandahl, Søren

    2012-01-01

    Customer value is a key goal in the Lean philosophy, essentially only actions that adds value should be conducted. In a transformation view, the basic lean approach is to remove waste, which indirectly increases value (or withstand value lose). Lean Construction acknowledges two different types o...... be minimized and management should seek towards democratic leadership....

  20. Extending Value Logic Thinking to Value Logic Portfolios

    DEFF Research Database (Denmark)

    Andersen, Poul Houman; Ritter, Thomas

    2014-01-01

    Based on value creation logic theory (Stabell & Fjeldstad, 1998), this paper suggests an extension of the original Stabell & Fjeldstad model by an additional fourth value logic, the value system logic. Furthermore, instead of only allowing one dominant value creation logic for a given firm...... or transaction, an understanding of firms and transactions as a portfolio of value logics (i.e. an interconnected coexistence of different value creation logics) is proposed. These additions to the original value creation logic theory imply interesting avenues for both, strategic decision making in firms...

  1. Economic value of walkability

    Energy Technology Data Exchange (ETDEWEB)

    Litman, T.

    2004-10-12

    Traditional transportation planning and evaluation practices treat walking as a minor transport mode. However, it is evident that walking is a critical component of the transport system. This paper presents a series of methods to evaluate the value of walking and walkability, which is defined as the quality of walking conditions, including safety, comfort and convenience. The socio-economic benefits of walking and walkability were discussed, including basic mobility, consumer cost savings and reduced external costs. Efficient land use, community livability, improved public health, economic development and support for equity objectives were also presented as potential benefits. It was concluded that walking receives less than its appropriate share of transportation resources, and that improvements in walkability can provide a high economic return on investment. Increased government funding to walking facilities and programs was recommended. Other recommendations included: shifting road space from traffic and parking lanes to sidewalks and paths; and policies to create more walkable safety and comfort. These recommendations comply with other transport and land use management reforms to reduce automobile dependency and create greater accessibility. refs., tabs., figs.

  2. The Value of Inequality

    Directory of Open Access Journals (Sweden)

    Gustaaf Bos

    2016-11-01

    Full Text Available Over the last two decades, inclusion and participation have become leading policy concepts within the Dutch chronic care and social welfare sector. People with an intellectual or psychiatric disability ought to get a chance to participate in, and belong to, the mainstream of our society—on the basis of equality and equivalence. Although on an international level this pursuit has been going on for at least five decades, it still raises all kinds of questions and debates. What does it mean if we want people with intellectual and/or psychiatric disabilities to participate in our society? Based on which idea(ls about humanity do we define equality and equivalence? And by doing so, how much space is left for individual differences? In the following dialogue the two authors navigate the tension between similarity and difference in thinking about—and working towards—more space for marginalized people. In an attempt to withstand the contemporary dominance of equality thinking, marked by a strong focus on tenability and autonomy—and by extension an increasing climate of taboo around vulnerability and dependency—both authors stress the importance of recognizing and valuing difference, while discussing encounters between people with and without a severe intellectual and/or multiple disability.

  3. Digital Information and Value

    Directory of Open Access Journals (Sweden)

    Paul Walton

    2015-11-01

    Full Text Available Digital information changes the ways in which people and organisations interact. This paper examines the nature of this change in the context of the author’s Model for Information (MfI. It investigates the relationship between outcomes and value, selection processes and some attributes of information and explores how this relationship changes in the move from analogue to digital information. Selection processes shape the evolution of information ecosystems in which conventions are established for the ways in which information is used. The conventions determine norms for information friction and information quality as well as the sources of information and channels used. Digital information reduces information friction, often dramatically, and changes information quality. The increasing use of analytics in business increasingly delivers predictive or prescriptive digital information. These changes are happening faster than information ecosystem conventions can change. The relationships established in the paper enable an analysis of, and guide changes to, these conventions enabling a more effective use of digital information.

  4. Porter's value chain (construction, deconstruction, reconstruction) and values management

    OpenAIRE

    E.V. Krykavskyy; Z. Patora-Wysocka

    2015-01-01

    The aim of the article. The phases of the Porter's value chain are distinguished: construction of chain value – Porters model (Stage 1); deconstruction – identifying contradictions, disorganizing elements of unnecessary processes that do not add value (Stage 2); reconstruction (synthesis) – creates a new value chain (Stage 3). The results of the analysis. The principles of convergence of value and supply chains are identified and the need to focus on supply chain performance is proved. The...

  5. Showing Value (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2009-06-01

    Full Text Available When Su Cleyle and I first decided to start Evidence Based Library and Information Practice, one of the things we agreed upon immediately was that the journal be open access. We knew that a major obstacle to librarians using the research literature was that they did not have access to the research literature. Although Su and I are both academic librarians who can access a wide variety of library and information literature from our institutions, we belong to a profession where not everyone has equal access to the research in our field. Without such access to our own body of literature, how can we ever hope for practitioners to use research evidence in their decision making? It would have been contradictory to the principles of evidence based library and information practice to do otherwise.One of the specific groups we thought could use such an open access venue for discovering research literature was school librarians. School librarians are often isolated and lacking access to the research literature that may help them prove to stakeholders the importance of their libraries and their role within schools. Certainly, school libraries have been in decline and the use of evidence to show value is needed. As Ken Haycock noted in his 2003 report, The Crisis in Canada’s School Libraries: The Case for Reform and Reinvestment, “Across the country, teacher-librarians are losing their jobs or being reassigned. Collections are becoming depleted owing to budget cuts. Some principals believe that in the age of the Internet and the classroom workstation, the school library is an artifact” (9. Within this context, school librarians are looking to our research literature for evidence of the impact that school library programs have on learning outcomes and student success. They are integrating that evidence into their practice, and reflecting upon what can be improved locally. They are focusing on students and showing the impact of school libraries and

  6. Colorectal Cancer: Prognostic Values

    Directory of Open Access Journals (Sweden)

    Suzana Manxhuka-Kerliu

    2009-02-01

    Full Text Available After lung cancer colorectal cancer (Cc is ranked the second, as a cause of cancer-related death. The purpose of this study was to analyze the Cc cases in our material with respect to all prognostic values including histological type and grade, vascular invasion, perineural invasion, and tumor border features. There were investigated 149 cases of resection specimen with colorectal cancer, which were fixed in buffered neutral formalin and embedded in paraffin. Tissue sections (4(µm thick were cut and stained with H&E. Adenocarcinoma was the most frequent histological type found in 85,90% of cases, in 60,94% of males and 39,06% of females; squamous cell carcinoma in 7,38%, in 63,63% of males and 36,36% of females; mucinous carcinoma in 4,68%, in 57,15% of males and 42,85% of females; while adenosquamous carcinoma, undifferentiated carcinoma and carcinoma in situ in 0,71% of cases each. Dukes' classification was used in order to define the depth of invasion. Dukes B was found in 68,45% of cases, whereas in 31,54% of cases Dukes C was found. As far as histological grading is concerned, Cc was mostly with moderate differentiation (75,16% with neither vascular nor perineural invasion. Resection margins were in all cases free of tumor. Our data indicate that the pathologic features of the resection specimen constitute the most powerful predictors of postoperative outcome in Cc. Dukes' stage and degree of differentiation provide independent prognostic information in Cc. However, differentiation should be assessed by the worst pattern.

  7. Uniform Single Valued Neutrosophic Graphs

    Directory of Open Access Journals (Sweden)

    S. Broumi

    2017-09-01

    Full Text Available In this paper, we propose a new concept named the uniform single valued neutrosophic graph. An illustrative example and some properties are examined. Next, we develop an algorithmic approach for computing the complement of the single valued neutrosophic graph. A numerical example is demonstrated for computing the complement of single valued neutrosophic graphs and uniform single valued neutrosophic graph.

  8. An Introduction to Value Analysis.

    Science.gov (United States)

    Takacs, Kalman

    1983-01-01

    Emphasizes consciousness as a quality which differentiates a human being from other living organisms. Excerpts various perspectives that are value-analyzed to illustrate two assumptions: (1) thinking leads to valuing and values and (2) all psychological perspectives are based upon some value system which can be identified. (JAC)

  9. Value concepts and value based collaboration in building projects

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2005-01-01

    Value has in recent years become a popular term in management theory and practice in general as well as in economic theory and architectural management. This paper attempts to clarify the various uses and meanings of concepts of value/values. Six different value concepts are identified. The ori......-gin and use of value concepts in classic and modern economic theory and in management theory is outlined. The question of objectivity and subjectivity is discussed in relation to economic value and customer value. Value creation is put in relation to development in products and processes and a number...... of design strategies are identified. The concept and methods of value based management and collaboration is discussed in this context. The paper is mainly theoretical and based on work during a MBA study in 2002-04 as well as many years of experience as building client and facilities manager....

  10. Nurses' professional and personal values.

    Science.gov (United States)

    Rassin, Michal

    2008-09-01

    The purpose of this study was to measure professional and personal values among nurses, and to identify the factors affecting these values. The participants were 323 Israeli nurses, who were asked about 36 personal values and 20 professional values. The three fundamental professional nursing values of human dignity, equality among patients, and prevention of suffering, were rated first. The top 10 rated values all concerned nurses' responsibility towards patients. Altruism and confidentiality were not highly rated, and health promotion and nursing research were rated among the last three professional values. For personal (instrumental) values, honesty, responsibility and intelligence were rated first, while ambition and imagination were rated 14th and 16th respectively out of 18. Significant differences (P personal and professional values rated as functions of culture, education, professional seniority, position and field of expertise. The results may assist in understanding the motives of nurses with different characteristics and help to promote their work according to professional ethical values.

  11. In vitro evaluation of novel antiviral activities of 60 medicinal plants extracts against hepatitis B virus.

    Science.gov (United States)

    Arbab, Ahmed Hassan; Parvez, Mohammad Khalid; Al-Dosari, Mohammed Salem; Al-Rehaily, Adnan Jathlan

    2017-07-01

    Currently, >35 Saudi Arabian medicinal plants are traditionally used for various liver disorders without a scientific rationale. This is the first experimental evaluation of the anti-hepatitis B virus (HBV) potential of the total ethanolic and sequential organic extracts of 60 candidate medicinal plants. The extracts were tested for toxicity on HepG2.2.15 cells and cytotoxicity concentration (CC 50 ) values were determined. The extracts were further investigated on HepG2.2.15 cells for anti-HBV activities by analyzing the inhibition of HBsAg and HBeAg production in the culture supernatants, and their half maximal inhibitory concentration (IC 50 ) and therapeutic index (TI) values were determined. Of the screened plants, Guiera senegalensis (dichloromethane extract, IC 50 =10.65), Pulicaria crispa (ethyl acetate extract, IC 50 =14.45), Coccinea grandis (total ethanol extract, IC 50 =31.57), Fumaria parviflora (hexane extract, IC 50 =35.44), Capparis decidua (aqueous extract, IC 50 =66.82), Corallocarpus epigeus (total ethanol extract, IC 50 =71.9), Indigofera caerulea (methanol extract, IC 50 =73.21), Abutilon figarianum (dichloromethane extract, IC 50 =99.76) and Acacia oerfota (total ethanol extract, IC 50 =101.46) demonstrated novel anti-HBV activities in a time- and dose-dependent manner. Further qualitative phytochemical analysis of the active extracts revealed the presence of alkaloids, tannins, flavonoids and saponins, which are attributed to antiviral efficacies. In conclusion, P. crispa, G. senegalensis and F. parviflora had the most promising anti-HBV potentials, including those of C. decidua , C. epigeus, A. figarianum , A. oerfota and I. caerulea with marked activities. However, a detailed phytochemical study of these extracts is essential to isolate the active principle(s) responsible for their novel anti-HBV potential.

  12. Nutritional and Functional Bioactivity Value of Selected Azorean Macroalgae: Ulva compressa, Ulva rigida, Gelidium microdon, and Pterocladiella capillacea.

    Science.gov (United States)

    Paiva, Lisete; Lima, Elisabete; Neto, Ana Isabel; Marcone, Massimo; Baptista, José

    2017-07-01

    This study presents information on the biochemical composition (dry weight basis), nutritional aspects, and angiotensin I-converting enzyme (ACE) inhibitory properties of selected macroalgae (Ulva compressa, Ulva rigida, Gelidium microdon, and Pterocladiella capillacea) from Azores. Moisture content was very high (83.2% to 90.0% of fresh weight). Total dietary fiber (33.7% to 41.0%) that presented a good balance of both soluble and insoluble fibers (15.5% to 19.2% and 18.2% to 21.8%, respectively) was the most abundant component in these macroalgae. Protein and ash (ranged from 15.7% to 23.4% and 10.7% to 20.7%, respectively) were the 2nd most abundant components in red and green macroalgae, respectively. Moderate soluble carbohydrate contents (14.5% to 19.8%) were found in all species. Lipid contents were low (1.0% to 4.3%), particularly in Ulva species (1.0% to 1.7%), but contained higher unsaturated fatty acids (FAs) (7.5% to 32.9% and 29.6% to 69.2% of total FA for monounsaturated fatty acid and polyunsaturated fatty acid groups, respectively) than saturated fatty acid (23.3% to 46.8% of total FA) contents. All the macroalgal proteins had high digestibility in vitro (82.2% to 89.4%, relatively to sodium caseinate), contained high quantity of essential amino acids (45.3% to 58.1% of total amino acids), but in different proportions, and were rich in aspartic and glutamic acids that together account for 17.2% to 36.2% of the total amino acids. These results suggested that regular consumption of the selected macroalgae may improve human health and revealed that they can be used for producing food supplements for human and animal nutrition and/or pharmaceuticals with potential effect on the regional economy. Furthermore, the ACE-inhibitory IC 50 values of 0.095 to 0.695 mg/mL for the <1 kDa protein hydrolysate fraction revealed a potential impact on hypertension disorder. © 2017 Institute of Food Technologists®.

  13. Values in a Science of Social Work: Values-Informed Research and Research-Informed Values

    Science.gov (United States)

    Longhofer, Jeffrey; Floersch, Jerry

    2014-01-01

    While social work must be evaluative in relation to its diverse areas of practice and research (i.e., values-informed research), the purpose of this article is to propose that values are within the scope of research and therefore research on practice should make values a legitimate object of investigation (i.e., research-informed values). In this…

  14. Stakeholder Value Matrix - Die VErbindung zwischen Shareholder Value und Stakeholder Value

    OpenAIRE

    Frank Figge

    2004-01-01

    Die Studie zeigt, was unter Stakeholder Value verstanden werden kann, wie Shareholder Value und Stakeholder Value gemessen werden können und welche Verbindung zwischen beiden Konzepten besteht. In dieser Studie wird erstmals die Wertbeitragsanalyse von Stakeholderbeziehungen vorgestellt. Anhand der Stakeholder Value Matrix lässt sich zeigen, welche Stakeholdergruppen zusammen positiv zum Unternehmenswert beitragen.

  15. Shared Values?: Measuring Value Differences Between Civilians and Soldiers

    National Research Council Canada - National Science Library

    Efflandt, Scott

    1998-01-01

    .... In response to this many within and outside of the military have attributed these problems to the absence of personal values among new service members that are congruent with the military's core values...

  16. Dairy farmers’ values and how their values affect their decision

    Directory of Open Access Journals (Sweden)

    Bjørn Gunnar Hansen

    2014-11-01

    Full Text Available Values affect humans’ perception of situations and problems and guide our actions. The objective of this study was to explore the values of dairy farmers, and whether their values influenced their decisions to maintain dairy farming or to buy consultancy services. During late fall 2007 we visited and interviewed 90 farmers. First we did a qualitative analysis of the data and then we merged the interview data with the existing database of financial data from the year 2007 to do statistical analyses. We also checked whether the farmers still produced milk in 2013, six years after the interviews.  Most farmers had terminal values like keeping up the tradition and to have an interesting work. Value combinations with instrumental values such as to earn money and to produce milk were common. Realizing that many farmers prioritize terminal values over instrumental values has important consequences for dairy companies, dairy consultants and politicians.

  17. Customer Value Controlling ¨C Combining Different Value Perspectives

    OpenAIRE

    Andreas Kramer; Thomas Burgartz

    2015-01-01

    The article begins by presenting a model for the structuring of customer data which can be used to demonstrate the value of data in different forms of aggregation. Since Customer Value plays a crucial role in this model the term is examined more closely. As part of a value-based customer relationship management critical parameters are customer benefits and customer profitability. Both perspectives are included in the term Customer Value. A segmentation approach is shown which integrates the k...

  18. Teacher Values and Relationship: Factors in Values Education

    Science.gov (United States)

    Brady, Laurie

    2011-01-01

    Intrigued by the notion that effective teaching is as much about relationship as it is about "technical" proficiency, the author examines the values of teachers that inform classroom relationships, and poses the question as to whether there are particular teacher values that are necessary for quality values education. This question is…

  19. "Value"ing Children Differently? Migrant Children in Education

    Science.gov (United States)

    Devine, Dympna

    2013-01-01

    This paper considers dilemmas around "value" and the "valuing" of children and childhood(s) in schools. I argue that in neo-liberal contexts, processes of children's identity making become aligned with the idea of the corporate citizen--value and worth derived from the capacity to produce, excel, self-regulate as well as…

  20. Value dynamics and infrastructure reform

    DEFF Research Database (Denmark)

    Beck Jørgensen, Torben

    2009-01-01

    varying decision making contexts bear on the role of values and the handling of values. A number of theoretical explanations of value change are presented, from teleological explanations to pendulum dynamics and life cycle theories. The paper concludes with suggestions on how to deal with normative......This paper identifies the aspects of value dynamics in each of the previous papers: how the choice of institutional arrangements give primacy to some values and others not; the law and the market as separate dynamic forces; the different time horizons involved when studying value changes; and how...

  1. Leadership values in academic medicine.

    Science.gov (United States)

    Souba, Wiley W; Day, David V

    2006-01-01

    To gain a deeper understanding of the guiding core values that deans of academic medical centers (AMCs) considered most essential for their leadership and the major leadership challenges that confront them. In 2003-04, semistructured interviews of 18 deans at U.S. colleges of medicine or AMCs were organized around four dimensions: background, leadership challenges, organizational effectiveness, and systems enablers/restrainers for leadership. A values Q-sort was used to determine how widely core values were shared among deans and how the complex challenges they faced did or did not align with these values. Fourteen of the 18 (78%) deans identified financial difficulties as their most pressing leadership challenge, followed by weak institutional alignment (61%), staffing problems (33%), and poor morale (28%). Open, candid communication was reported as the most effective means of addressing these complex problems. Enacting espoused shared values and having a positive attitude were identified as the most important enablers of systemic leadership, whereas micromanagement and difficult people were the major restraints. Q-sort results on 38 positive leadership values indicated that participants considered integrity most essential. Integrity was positively correlated with humanistic values and negatively correlated with results. Vision, another highly espoused value, correlated strongly with performance-oriented values but correlated negatively with humanistic values. A dynamic tension exists in AMCs between humanistic values and performance-based core values. The ability to manage that tension (i.e., when to prioritize one set of values over the other) is inherent in a dean's work.

  2. Age and personal values: Similar value circles with shifting priorities.

    Science.gov (United States)

    Borg, Ingwer; Hertel, Guido; Hermann, Dieter

    2017-11-01

    This study examined the relationship of personal values to age using data from two representative surveys. We hypothesized that individuals organize personal values, regardless of their age, as a circle with the same order of values on this circle but that older persons are closer to conservation and more remote from openness to change and closer to self-transcendence and more distant from self-enhancement. The structural stability of the value circle over age was largely confirmed across and within individuals. Different age groups exhibited a tendency to more strongly cluster those values that they rated as relatively important. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  3. Christian Contributions to Army Values

    National Research Council Canada - National Science Library

    D'Emma, Gregory

    2000-01-01

    .... The Army builds the soldier's heart, spirit, and soul by the values we instill. Over the years these values of loyalty, duty, respect, selfless service, honor, integrity, and personal courage have been trained and reinforced...

  4. Values-led Participatory Design - Mediating the Emergence of Values

    DEFF Research Database (Denmark)

    Iversen, Ole Sejer; Leong, Tuck Wah

    2012-01-01

    There is a growing interest in values-led inquiries within participatory design. One approach argues that working with values is a recursive 3-phase process that supports the emergence, development and grounding of values. In this paper we focus solely upon the emergence phase, proposing...... an approach that can support the emergence of values during the initial phase of a values-led inquiry. To illustrate this approach and to ground our discussion, we draw from a recent participatory design case where we were engaged in the design of digital technology to support the experiences of young adults...... with severe intellectual disabilities, in an art museum. By describing how we establish, negotiate and the debrief values during this initial phase of a values-led inquiry. By foregrounding both explicit and implicit mediation in the PD process we show how a theoretical understanding of mediation can...

  5. Neurocognitive Mechanisms Underlying Value-Based Decision-Making: From Core Values to Economic Value

    Directory of Open Access Journals (Sweden)

    Tobias eBrosch

    2013-07-01

    Full Text Available Value plays a central role in practically every aspect of human life that requires a decision: whether we choose between different consumer goods, whether we decide which person we marry or which political candidate gets our vote, we choose the option that has more value to us. Over the last decade, neuroeconomic research has mapped the neural substrates of economic value, revealing that activation in brain regions such as ventromedial prefrontal cortex (VMPFC, ventral striatum or posterior cingulate cortex reflects how much an individual values an option and which of several options he/she will choose. However, while great progress has been made exploring the mechanisms underlying concrete decisions, neuroeconomic research has been less concerned with the questions of why people value what they value, and why different people value different things. Social psychologists and sociologists have long been interested in core values, motivational constructs that are intrinsically linked to the self-schema and are used to guide actions and decisions across different situations and different time points. Core value may thus be an important determinant of individual differences in economic value computation and decision-making. Based on a review of recent neuroimaging studies investigating the neural representation of core values and their interactions with neural systems representing economic value, we outline a common framework that integrates the core value concept and neuroeconomic research on value-based decision-making.

  6. Neurocognitive mechanisms underlying value-based decision-making: from core values to economic value.

    Science.gov (United States)

    Brosch, Tobias; Sander, David

    2013-01-01

    VALUE PLAYS A CENTRAL ROLE IN PRACTICALLY EVERY ASPECT OF HUMAN LIFE THAT REQUIRES A DECISION: whether we choose between different consumer goods, whether we decide which person we marry or which political candidate gets our vote, we choose the option that has more value to us. Over the last decade, neuroeconomic research has mapped the neural substrates of economic value, revealing that activation in brain regions such as ventromedial prefrontal cortex (VMPFC), ventral striatum or posterior cingulate cortex reflects how much an individual values an option and which of several options he/she will choose. However, while great progress has been made exploring the mechanisms underlying concrete decisions, neuroeconomic research has been less concerned with the questions of why people value what they value, and why different people value different things. Social psychologists and sociologists have long been interested in core values, motivational constructs that are intrinsically linked to the self-schema and are used to guide actions and decisions across different situations and different time points. Core value may thus be an important determinant of individual differences in economic value computation and decision-making. Based on a review of recent neuroimaging studies investigating the neural representation of core values and their interactions with neural systems representing economic value, we outline a common framework that integrates the core value concept and neuroeconomic research on value-based decision-making.

  7. Neurocognitive mechanisms underlying value-based decision-making: from core values to economic value

    Science.gov (United States)

    Brosch, Tobias; Sander, David

    2013-01-01

    Value plays a central role in practically every aspect of human life that requires a decision: whether we choose between different consumer goods, whether we decide which person we marry or which political candidate gets our vote, we choose the option that has more value to us. Over the last decade, neuroeconomic research has mapped the neural substrates of economic value, revealing that activation in brain regions such as ventromedial prefrontal cortex (VMPFC), ventral striatum or posterior cingulate cortex reflects how much an individual values an option and which of several options he/she will choose. However, while great progress has been made exploring the mechanisms underlying concrete decisions, neuroeconomic research has been less concerned with the questions of why people value what they value, and why different people value different things. Social psychologists and sociologists have long been interested in core values, motivational constructs that are intrinsically linked to the self-schema and are used to guide actions and decisions across different situations and different time points. Core value may thus be an important determinant of individual differences in economic value computation and decision-making. Based on a review of recent neuroimaging studies investigating the neural representation of core values and their interactions with neural systems representing economic value, we outline a common framework that integrates the core value concept and neuroeconomic research on value-based decision-making. PMID:23898252

  8. The Value of Personal Data

    OpenAIRE

    Lieshout , Marc ,

    2015-01-01

    Part 1: Invited Keynote Papers; International audience; This chapter discusses the value of personal data from two complementary perspectives: the value of personal data for firms and the value of personal data for individuals. The chapter starts with a short introduction into the rise of personal data markets – markets basically driven by the economic exploitation of personal data. Then the chapter discusses how firms asses the value of personal data. This can be done from different angles, ...

  9. Value definitions and consumer consciousness

    OpenAIRE

    Wakenshaw, Susan Y. L.; Phillips, Laura; Ng, Irene C. L.

    2014-01-01

    This paper contributes to the understanding of value within the service science and management literature, a literature that currently defines and measures value in various ways, making assumptions about how value is created and judged. We present this paper in two parts: in the first, we reprise six core themes of value understanding in the management literature, highlighting their implicit philosophical, chronological and consciousness assumptions; in the second, we elaborate on consciousne...

  10. Regular Single Valued Neutrosophic Hypergraphs

    Directory of Open Access Journals (Sweden)

    Muhammad Aslam Malik

    2016-12-01

    Full Text Available In this paper, we define the regular and totally regular single valued neutrosophic hypergraphs, and discuss the order and size along with properties of regular and totally regular single valued neutrosophic hypergraphs. We also extend work on completeness of single valued neutrosophic hypergraphs.

  11. 77 FR 15250 - Value Engineering

    Science.gov (United States)

    2012-03-15

    ...-2011-0046] RIN 2125-AF40 Value Engineering AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Final rule. SUMMARY: This rule updates regulations to enhance the integration of value engineering (VE... Office of Management and Budget (OMB) Circular A-131 on Value Engineering. These revisions also will...

  12. 77 FR 34073 - Value Engineering

    Science.gov (United States)

    2012-06-08

    ... OFFICE OF MANAGEMENT AND BUDGET Office of Federal Procurement Policy Value Engineering AGENCY... Office of Management and Budget Circular No. A-131, ``Value Engineering''. SUMMARY: The Office of Federal...- 131, Value Engineering, to update and reinforce policies associated with the consideration and use of...

  13. 76 FR 36410 - Value Engineering

    Science.gov (United States)

    2011-06-22

    ...-2011-0046] RIN 2125-AF40 Value Engineering AGENCY: Federal Highway Administration (FHWA), DOT. ACTION... regulations to enhance the integration of value engineering (VE) analysis in the planning and development of...-131 on Value Engineering. These revisions will also address certain findings contained in a 2007...

  14. 78 FR 53380 - Value Engineering

    Science.gov (United States)

    2013-08-29

    ...-2013-0039] RIN 2125-AF64 Value Engineering AGENCY: Federal Highway Administration (FHWA), U.S.... SUMMARY: The FHWA proposes to update the existing value engineering (VE) regulations to make the... provided. FOR FURTHER INFORMATION CONTACT: Mr. Ken Leuderalbert, Value Engineering and Utilities Program...

  15. 78 FR 78399 - Value Engineering

    Science.gov (United States)

    2013-12-26

    ... OFFICE OF MANAGEMENT AND BUDGET Office of Federal Procurement Policy Value Engineering AGENCY... to Office of Management and Budget Circular No. A-131, ``Value Engineering''. SUMMARY: The Office of... revisions to OMB Circular A-131, Value Engineering, to update and reinforce policies associated with the...

  16. Moral values in teacher education

    NARCIS (Netherlands)

    Veugelers, W.; Peterson, P.; Baker, E.; McGaw, B.

    2010-01-01

    Moral values are interwoven in all aspects of teaching: in the curriculum, in the school culture, and as moral examples in teachers' behavior. Working with values is an essential part of teaching. Educating students to become teachers requires the teachers to learn how values are embedded in

  17. Competing values in public management

    NARCIS (Netherlands)

    van der Wal, Z.; de Graaf, G.; Lawton, A.

    2011-01-01

    The main objective of the article is to review relevant literature on (competing) public values in public management and to present a number of perspectives on how to deal with value conflicts in different administrative settings and contexts. We start this symposium with the assumption that value

  18. Married Women, Work, and Values.

    Science.gov (United States)

    Jalilvand, Mahshid

    2000-01-01

    Working women appear to have a personal-value structure different from that of nonworking women. Economic and political values are more prominent among women who work, whereas social and religious values play a greater role for women who stay at home. (JOW)

  19. Principals' Values in School Administration

    Science.gov (United States)

    Aslanargun, Engin

    2012-01-01

    School administration is value driven area depending on the emotions, cultures, and human values as well as technique and structure. Over the long years, educational administration throughout the world have experienced the influence of logical positivism that is based on rational techniques more than philosophical consideration, ignored values and…

  20. Make your values mean something.

    Science.gov (United States)

    Lencioni, Patrick M

    2002-07-01

    Take a look at this list of corporate values: Communication. Respect. Integrity. Excellence. They sound pretty good, don't they? Maybe they even resemble your own company's values. If so, you should be nervous. These are the corporate values of Enron, as claimed in its 2000 annual report. And they're absolutely meaningless. Indeed, most values statements, says the author, are bland, toothless, or just plain dishonest. And far from being harmless, as some executives assume, they're often highly destructive. Empty values statements create cynical and dispirited employees and undermine managerial credibility. But coming up with strong values--and sticking to them--isn't easy. Organizations that want their values statements to really mean something should follow four imperatives. First, understand the different types of values: core, aspirational, permission-to-play, and accidental. Confusing them with one another can bewilder employees and make management seem out of touch. Second, be aggressively authentic. Too many companies view a values initiative in the same way they view a marketing launch: a onetime event measured by the initial attention it receives, not by its content. Third, own the process. Values initiatives are about imposing a set of fundamental, strategically sound beliefs on a broad group of people. That's why the best values efforts are driven by small teams. Finally, weave core values into everything. It's not enough to hang your values statement on the wall; it must be integrated into every employee-related process--hiring methods, performance management systems, even dismissal policies. Living by stated corporate values is difficult. But the benefits of doing so can be profound; so can the damage from adopting a hollow set of corporate values.

  1. Health values and prospect theory.

    Science.gov (United States)

    Treadwell, J R; Lenert, L A

    1999-01-01

    Health values are important components of medical decisions. Experimental data suggest that people value health in complex and dynamic ways. Prospect theory is a descriptive theory of choice that may accurately characterize how people assign values to health states. The authors first provide background on prospect theory and how it can be applied to health values. Next, they review the relevant health research and find mixed support for prospect theory. Last, they discuss implications of prospect theory for cost-effectiveness analysis. The application of prospect theory to health deserves further research because it may help clarify the link between health and values.

  2. Measuring value sensitivity in medicine.

    Science.gov (United States)

    Ineichen, Christian; Christen, Markus; Tanner, Carmen

    2017-01-28

    Value sensitivity - the ability to recognize value-related issues when they arise in practice - is an indispensable competence for medical practitioners to enter decision-making processes related to ethical questions. However, the psychological competence of value sensitivity is seldom an explicit subject in the training of medical professionals. In this contribution, we outline the traditional concept of moral sensitivity in medicine and its revised form conceptualized as value sensitivity and we propose an instrument that measures value sensitivity. We developed an instrument for assessing the sensitivity for three value groups (moral-related values, values related to the principles of biomedical ethics, strategy-related values) in a four step procedure: 1) value identification (n = 317); 2) value representation (n = 317); 3) vignette construction and quality evaluation (n = 37); and 4) instrument validation by comparing nursing professionals with hospital managers (n = 48). We find that nursing professionals recognize and ascribe importance to principle-related issues more than professionals from hospital management. The latter are more likely to recognize and ascribe importance to strategy-related issues. These hypothesis-driven results demonstrate the discriminatory power of our newly developed instrument, which makes it useful not only for health care professionals in practice but for students and people working in the clinical context as well.

  3. Value Appropriation in Business Exchange

    DEFF Research Database (Denmark)

    Ellegaard, Chris; Medlin, Christopher J.; Geersbro, Jens

    2014-01-01

    value creation. Originality/value – To the authors’ knowledge, this paper represents the first attempt at reviewing the management literature on value appropriation in business exchange. The authors provide overview, details, comparisons, and frame a research agenda as a first step towards establishing......Purpose – Value appropriation is a central, yet neglected aspect in business exchange research. The purpose of the paper is to generate an overview of research on active value appropriation in business exchange and provide the foundation for further research into value appropriation, as well...... as some initial guidance for managers. Design/methodology/approach – Literatures investigating value appropriation were identified by the means of a systematic review of the overall management literature. Findings – The authors provide an overview and comparison of the literatures and find that they apply...

  4. School Values Across Three Cultures

    Directory of Open Access Journals (Sweden)

    Ella Daniel

    2013-04-01

    Full Text Available A new typology of school-level values is reported in three cultural contexts. School values were assessed by aggregating the scores of 862 students, (ages 15-19 in 32 Jewish and Arab Israeli schools (Study 1, and 1,541 students (ages 11-21 from 8 European schools and 163 teachers from 6 of these schools (Study 2, using Schwartz’s Portrait Values Questionnaire. Six school values emerged in both studies: achievement, autonomy, egalitarianism, harmony, compliance, and dominance. The importance of studying school-level values was demonstrated by relating the values of compliance and dominance to violence, and harmony values to student support measures (Study 1. Strong (minimal r = .64 school-level correlations between students of different ages and teachers supported the validity of the findings (Study 2.

  5. The value relevance of investment property fair value

    OpenAIRE

    Selas, Duarte Nuno Gonçalves da Costa

    2009-01-01

    A Work Project, presented as part of the requirements for the Award of a Masters Degree in Finance from the NOVA – School of Business and Economics This paper examines if the use of the fair value model is value relevant in companies where the investment properties are not their core business. An analysis is also made into whether the disclosed fair value of investment property is perceived by investors. The sample includes Portuguese listed companies subject to the mandatory adoption of I...

  6. FRANCHISE VALUE AND AN APPLICATION ABOUT DETERMINATION OF FRANCHISE VALUE

    Directory of Open Access Journals (Sweden)

    BANU KÜLTER

    2013-06-01

    Full Text Available This study is involved with the basic concepts of franchising, franchisor-franchisee relationship and value, and the underlying reasons of franchising. Besides, franchise value and its determination via discounted cash flow valuation technique are tried to be undertaken in both marketing and finance perspectives. The mentioned application is a valuation attempt about the determination of value of taxi enterprises whose business styles are so similar with franchising operations.

  7. Value Relevance of Embedded Value and IFRS 4 Insurance Contracts

    OpenAIRE

    Rebecca Chung-Fern Wu; Audrey Wen-Hsin Hsu

    2011-01-01

    In light of the recent exodus of foreign insurers from Taiwan and the local insurers’ outcries against the International Financial Reporting Standard (IFRS) 4 Insurance Contracts, we examine the value relevance of financial statements for life insurance firms, with particular interests to the embedded value (EV) disclosure. We find that the EV of equity has an incremental information role for book value of equity, which indicates that the accounting mismatching problem in the insurance indust...

  8. The value of crop germplasm and value accounting system

    Institute of Scientific and Technical Information of China (English)

    WANG Xiaowei; DING Guangzhou; CHANG Ying

    2007-01-01

    The value evaluation and accounting of crop germplasm not only provides the theory and method for the price of germplasm, thus makes further lawful and fair transactions, but also ensures the benefits of crop germplasm owners and is also instructive in keeping the foodstuff safety. This paper founded a multidimensional value accounting system, which included physical accounting, value accounting and quality index accounting; individual accounting and total accounting; quantity accounting and quality accounting.

  9. Kapasitas Antioksidan Ekstrak Buah Salak (Salacca Zalacca (Gaertn.) Voss) Varian Gula Pasir Menggunakan Metode Penangkapan Radikal Dpph

    OpenAIRE

    Puspitasari, Endah; Ningsih, Indah Yulia

    2016-01-01

    The aim of this study was to evaluate antioxidant capacity of gula pasir variant of snake fruit (Salacca zalacca (Gaertn.) Voss) water extract using free radical scavenging activity of the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). The inhibition concentration (IC50) sufficient to elicit 50% of a maximum effect estimated in 100% was 40.89±6.35 μg/mL for the DPPH radical scavenging activity. While the positive control, quercetin, had IC50 value of 8.79±0.90 μg/mL. Based on the IC50 value, w...

  10. Values beyond value? Is anything beyond the logic of capital?

    Science.gov (United States)

    Skeggs, Bev

    2014-03-01

    We are living in a time when it is frequently assumed that the logic of capital has subsumed every single aspect of our lives, intervening in the organization of our intimate relations as well as the control of our time, including investments in the future (e.g. via debt). The theories that document the incursion of this logic (often through the terms of neoliberalism and/or governmentality) assume that this logic is internalized, works and organizes everything including our subjectivity. These theories performatively reproduce the very conditions they describe, shrinking the domain of values and making it subject to capital's logic. All values are reduced to value. Yet values and value are always dialogic, dependent and co-constituting. In this paper I chart the history by which value eclipses values and how this shrinks our sociological imagination. By outlining the historical processes that institutionalized different organizations of the population through political economy and the social contract, producing ideas of proper personhood premised on propriety, I detail how forms of raced, gendered and classed personhood was formed. The gaps between the proper and improper generate significant contradictions that offer both opportunities to and limits on capitals' lines of flight. It is the lacks, the residues, and the excess that cannot be captured by capital's mechanisms of valuation that will be explored in order to think beyond the logic of capital and show how values will always haunt value. © London School of Economics and Political Science 2014.

  11. THE INFLUENCE OF ECONOMIC VALUE ADDED AND MARKET VALUE ADDED ON CORPORATE VALUE

    Directory of Open Access Journals (Sweden)

    Taslim F.A.

    2018-02-01

    Full Text Available This research aims to determine the influence of economic value added and market value added on corporate value of manufacturing companies on sector consumer goods industry listed in Indonesia Stock Exchanges of 2011-2014. The sample of this research was 10 manufacturing companies on sector consumer goods industry listed in Indonesia Stock Exchanges. The method used was purposive sampling technique. This research used confirmatory factor analysis to form a combined proxy of corporate value comprised price earning ratio, price to book value and Tobin's Q.

  12. Customer value - the missing link

    International Nuclear Information System (INIS)

    Pierce, A.R.; Martin, M.G.; Wagner, V.E.

    1993-01-01

    For many years electric utilities found it easy to provide value to their shareholders. With a monopoly service and decreasing costs it was easy to sell 70% more electricity each year and earn attractive returns. In the last 20 years electric utilities have teamed that it is not possible to provide value to their shareholders without providing value to their customers. Detroit Edison is learning that customer value is not always what the utility thinks it is. There is no better way to find out what customers value than to ask them. Detroit Edison has done a lot of direct asking in the last couple of years, through market research and individual interviews, and has learned indirectly from customers when a particular program does not succeed as we thought it should. Two areas where more has been learned about customer value are Demand Side Management (DSM) and Power Quality

  13. Value Creation in International Business

    DEFF Research Database (Denmark)

    The edited collection brings into focus the meanings, interpretations and the process of value creation in international business. Exploring value creation in the context of emerging and developed economies, Volume 2 takes the perspective of small and medium sized enterprises and examines various...... approaches to value creation in the process of firm internationalization. Providing theoretical and practical insights, the authors open an intellectual debate into what value is, and how it is created through the internationalization activities of firms. Value Creation in International Business...... is a pioneering two volume work intended to provoke theoretical and empirical development in International Business research. Moreover, it is intended as a bridge between concepts derived from general business firm-level research agendas such as value creation and business model, and internationalization...

  14. What Is the Value of Value-Based Purchasing?

    Science.gov (United States)

    Tanenbaum, Sandra J

    2016-10-01

    Value-based purchasing (VBP) is a widely favored strategy for improving the US health care system. The meaning of value that predominates in VBP schemes is (1) conformance to selected process and/or outcome metrics, and sometimes (2) such conformance at the lowest possible cost. In other words, VBP schemes choose some number of "quality indicators" and financially incent providers to meet them (and not others). Process measures are usually based on clinical science that cannot determine the effects of a process on individual patients or patients with comorbidities, and do not necessarily measure effects that patients value; additionally, there is no provision for different patients valuing different things. Proximate outcome measures may or may not predict distal ones, and the more distal the outcome, the less reliably it can be attributed to health care. Outcome measures may be quite rudimentary, such as mortality rates, or highly contestable: survival or function after prostate surgery? When cost is an element of value-based purchasing, it is the cost to the value-based payer and not to other payers or patients' families. The greatest value of value-based purchasing may not be to patients or even payers, but to policy makers seeking a morally justifiable alternative to politically contested regulatory policies. Copyright © 2016 by Duke University Press.

  15. Attitudes of Social Studies Teachers toward Value and Values Education

    Science.gov (United States)

    Celikkaya, Tekin; Filoglu, Simge

    2014-01-01

    This research was conducted to determine how social studies teachers define value and "values education" as well as reveal the problems they encountered during the implementation. The participants in this study consisted of 17 social studies teachers from 12 primary schools (selected out of 39 primary schools in the city of Kirsehir…

  16. Good governance: Performance values and procedural values in conflict

    NARCIS (Netherlands)

    de Graaf, G.; Paanakker, H.L.

    2015-01-01

    Good governance codes usually end with a list of public values no one could oppose. A recurrent issue is that not all of these values—however desirable they are—can be achieved at the same time. With its focus on performance and procedural values of governance, this article zooms in on the conflict

  17. The value of safety and safety as a value

    NARCIS (Netherlands)

    Ratilainen, H.; Salminen, S.; Zwetsloot, G.I.J.M.; Perttula, P.; Starren, A.; Steijn, W.; Pahkin, K.; Drupsteen, L.; Puro, V.; Räsänen, T.; Aaltonen, M.; Berkers, F.; Kalakoski, V.

    2016-01-01

    The research presented in this document analyzes how safety values are defined and used in practice, in particular by managers, and how they affect employers’ and employees’ decisions and behaviour at work. The work comprises three complementary activities: a literature review on the value of safety

  18. Value poaching: framing the same values for competing political ends

    NARCIS (Netherlands)

    Nelson, T.E.; Lecheler, S.; Schuck, A.R.T.; de Vreese, C.H.

    2015-01-01

    Previous research has established that rival issue frames that target competing values can lead public opinion in different directions. This article examines rival frames that target the same values but for competing political ends. We report on an experiment (N = 503) that examines the framing of a

  19. Values and Values Education in Estonian Preschool Child Care Institutions

    Science.gov (United States)

    Ülavere, Pärje; Veisson, Marika

    2015-01-01

    The objective of the study was to provide an outline of the values that principals, teachers and parents of preschool child care institutions consider important to be taught to children, and which activities, in their estimation, should be used to implement values education in child care institutions. A total of 978 respondents from all 15…

  20. FAIR VALUE: UTILITY AND LIMITS

    OpenAIRE

    Valentin Gabriel Cristea

    2015-01-01

    This paper presents the utility and the limits of the fair value. We believe that any new product must be tried and tested before being imposed on the market and must be accepted by all potential users and those who will be affected, directly or indirectly and its advantages, disadvantages, risks, its cost must be predetermined and analyzed in a comprehensive and objective.We ask: Do financial statements at fair value meet users' expectations? The requirement to use fair value pricing mode...

  1. Work values of future teachers

    OpenAIRE

    Liniauskaitė, Audronė; Zališčevskis, Antanas

    2005-01-01

    Learning to live under the network conditions, Lithuanian society is forced to change many things, including the approach towards the work values, which describe human work aspirations and reflect person's understanding of what is correct, good, and acceptable, etc. There is such a trend in the network society, that rational work values are being gradually replaced by the personality growth and interrelation-oriented values. The article presents the research, which aims at the examination of ...

  2. INCULCATION OF VALUE THROUGH COMMERCE

    OpenAIRE

    Hetal Kherala

    2014-01-01

    The problem of value education of the young student has assumed increasing prominence in educational discussions during recent times. Parents, teachers and society at large concerned about values and value education of children. We believe that education is expected to play a major role in promoting national development of all the faculties towards adequate preparation for life. Life of human is all most incomplete without commercial services. It is the social and moral responsibility of a bu...

  3. Achieving Value in Primary Care: The Primary Care Value Model.

    Science.gov (United States)

    Rollow, William; Cucchiara, Peter

    2016-03-01

    The patient-centered medical home (PCMH) model provides a compelling vision for primary care transformation, but studies of its impact have used insufficiently patient-centered metrics with inconsistent results. We propose a framework for defining patient-centered value and a new model for value-based primary care transformation: the primary care value model (PCVM). We advocate for use of patient-centered value when measuring the impact of primary care transformation, recognition, and performance-based payment; for financial support and research and development to better define primary care value-creating activities and their implementation; and for use of the model to support primary care organizations in transformation. © 2016 Annals of Family Medicine, Inc.

  4. Achieving excellence through organizational values.

    Science.gov (United States)

    DeForest, C; Lazio, M M; Rayder, N

    1986-03-01

    By focusing on its mission values, a hospital can enhance the quality of patient care, improve staff morale, promote cost-effectiveness, and achieve a competitive advantage in the hospital marketplace. Since 1979 Saint Joseph Hospital, Kansas City, MO, has conducted a project to clarify and apply its values to the organization's overall direction and the everyday work setting. The project has proven that a concentration on mission values can benefit both the hospital's basic "spirit" and its bottom line. Twelve guiding principles are essential to creating a values-focused hospital: 1. Begin with a commitment. 2. Identify, involve, and educate "stakeholders". 3. Identify and use appropriate resources. 4. Assess organizational needs. 5. Identify the organization's values. 6. Translate mission values into everyday language. 7. Use an explicit, visible process built with a core set of process tools. 8. Document and showcase results. 9. Link the values work to the organization's overall direction and goals and to day-to-day management issues. 10. Think and act strategically. 11. Weave values focus into the fabric of the organization to ensure permanence and long-term success. 12. Model behavior on values.

  5. Rekindling Values in Participatory Design

    DEFF Research Database (Denmark)

    Iversen, Ole Sejer; Halskov, Kim; Leong, Tuck Wah

    2010-01-01

    Drawing from our PD projects, this paper shows how designers enact their appreciative judgment of values by engaging in a dynamic and dialogical process of cultivating the emergence of values, developing them, and supporting their grounding. The widespread of Participatory Design (PD), have meant...... that different approaches and conceptualization exist in this field today. We argue that one fruitful approach is to rekindle a concern for values in PD—to return to one of the original tenets of PD. This requires focusing upon values as the engine that drives our activities in PD....

  6. Values-Led Participatory Design

    DEFF Research Database (Denmark)

    Iversen, Ole Sejer; Halskov, Kim; Leong, Tuck Wah

    2012-01-01

    The widespread use of participatory design (PD) has meant that different approaches and conceptualisations exist in this field today. In this article, it is argued that one fruitful approach is to rekindle a concern for values in design, focusing upon values as the engine that drives activities...... in PD. Drawing from the authors‘ own PD projects, this article shows how this can be accomplished: through designers enacting their appreciative judgement of values by engaging in a dynamic and dialogical process of cultivating the emergence of values, developing them and supporting their grounding....

  7. Valuing future citizens' values regarding risk

    Energy Technology Data Exchange (ETDEWEB)

    Fleming, Patricia [Creighton Univ., Omaha (United States). College of Arts and Sciences/Philosophy

    2006-09-15

    Valuing present citizen's values regarding the risks they face is an important aspect of risk assessment and risk acceptability. Conferences like VALDOR are held for this reason. Governments like Sweden have national referendums on various risk-prone enterprises. The results of these referendums can determine the future of these programs. In the United States, when guidelines are set for determining acceptable levels of risk, the relevant federal agencies are often required to provide a comment period regarding proposed guidelines in order to ascertain the judgments, including the weights place on certain values, of individual members of society as well as stakeholder groups. After the comment period ends, the agency decides on the acceptable level of risk, taking into account the comments from present citizens. Do we also have a duty to value the not-yet-existing values of future citizens, especially if the risks created by the activities of present citizens extend into the future to citizens not yet living? If so, are there any circumstances which entitle us to de-value those not-yet-existing values. In this paper, I ground my discussion of the question of valuing future citizens' values in one of the areas of focus of the VALDOR conference: nuclear waste management and specifically the question facing the United States' program regarding an acceptable dose standard associated with the release of radioactivity into the biosphere from an underground repository. The underlying conference theme to which this discussion may be attached is community environmental justice as it applies to future citizens. I focus on the role that uncertainty plays is providing justice between present and future citizens.

  8. Congruence and functions of personal and cultural values: do my values reflect my culture's values?

    Science.gov (United States)

    Fischer, Ronald

    2006-11-01

    Two studies are described examining the correlation between self- and culture-referenced values at a culture level (Study 1) and correlation between self- and culture-referenced values and self-reported behavior at an individual level (Study 2). It is found that values related to individual-group relationships (embeddedness) and expression and experience of affective feelings and emotions (affective autonomy) are significantly correlated at a culture level. In Study 2, culture-referenced values are shown to correlate with behaviors attached to social norms, whereas self-rated values are found to correlate with behaviors that are not norm-governed. Implications for measurement of cultural values and cultural and cross-cultural research designs are discussed.

  9. Business value of solution architecture

    NARCIS (Netherlands)

    Slot, R.; Dedene, G.; Maes, R.; Proper, E.; Harmsen, F.; Dietz, J.L.G.

    2009-01-01

    The theory and especially the practice of IT architecture have been developed quite vigorously the last years. However, hardly any quantitative data about the value of IT architecture is available. This paper presents the results of a study, which measures the value of IT solution architecture for

  10. The Specific Value of Freedom

    NARCIS (Netherlands)

    van Hees, Martin

    2010-01-01

    Freedom is among the most important values in political life, yet there has always been a great deal of disagreement about what this value demands from us. Libertarians argue that it requires that we protect each person's right to own and exchange private property. Liberals argue that it requires

  11. The Value of Literacy Practices

    Science.gov (United States)

    Esposito, Lucio; Kebede, Bereket; Maddox, Bryan

    2015-01-01

    The concepts of literacy events and practices have received considerable attention in educational research and policy. In comparison, the question of value, that is, "which literacy practices do people most value?" has been neglected. With the current trend of cross-cultural adult literacy assessment, it is increasingly important to…

  12. The economic value of autonomy

    NARCIS (Netherlands)

    Boot, A.W.A.; Thakor, A.V.

    2003-01-01

    We develop an economic theory of "autonomy", which we interpret as the discretion or ability to make a decision that others disagree with. We show that autonomy is essentially an option for the decisionmaker, and can be valued as such. The value of the autonomy option is decreasing in the extent to

  13. Vocational Interests and Basic Values.

    Science.gov (United States)

    Sagiv, Lilach

    2002-01-01

    Study 1 (n=97) provided evidence of the correlation of Holland's model of vocational interests with Schwartz' theory of basic values. Realistic career interests did not correlate with values. Study 2 (n=545) replicated these findings, showing a better match for individuals who had reached a career decision in counseling than for the undecided.…

  14. Value and power in economics

    Directory of Open Access Journals (Sweden)

    Josifidis Kosta

    2012-01-01

    Full Text Available In this article we rethink the field of value in economic theory. First, we prove that the transhistorical and nominalist approaches show different weaknesses and can not account for the constitutive dimensions of value. Within this context, we demonstrate why value emerged in the first place and what epistemological dimensions it provided and enabled for economic reflexivity. In addition, we demonstrate that it is impossible to understand inherent value as an immanent property of goods in economic transactions and we critique the approach that renders value to the theory of price. Economic relations reflect value-related aspects without which the relations could not be understood. We then analyze the interrelations between power and value, proving the constitutive dimension of power in understanding value, demonstrated in selected examples. We treat power as a constellation in which economic agents act on other subjects to provoke certain activity. Power may occur only where the behaviour of subjects is not entirely determined. Finally, one additional selected example shows the range of this theory of power in terms of positional goods.

  15. Cross-Cultural Faculty Values.

    Science.gov (United States)

    Keim, Marybelle C.

    1992-01-01

    Compares the terminal values of 24 visiting scholars from the People's Republic of China based at a midwestern community college with resident faculty values. The Chinese scholars ranked freedom, equality, and self-respect highest, whereas U.S. schools gave highest rankings to salvation, family security, and self-respect. Contrasts findings with a…

  16. Patterns of Wildlife Value Orientations

    Science.gov (United States)

    Harry C. Zinn; Michael J. Manfredo; Susan C. Barro

    2002-01-01

    Public value orientations toward wildlife may be growing less utilitarian and more protectionist. To better understand one aspect of this trend, we investigated patterns of wildlife value orientations within families. Using a mail survey, we sampled Pennsylvania and Colorado hunting license holders 50 or older; obtaining a 54% response rate (n = 599). Males (94% of...

  17. Life Role Salience and Values

    NARCIS (Netherlands)

    van Hattem, A.H.; Ossenkop, C.; Dikkers, J.S.E.; Vinkenburg, C.J.

    2013-01-01

    Purpose-Even though both values and life roles are intensively studied topics, limited research has been conducted regarding the association between the two. In the context of the Dutch public sector, this study therefore examines how life roles and values relate to each other. Moreover, the

  18. Pension accounting and fair value

    OpenAIRE

    Napier, Christopher

    2007-01-01

    The chapter reviews the applicability of the fair value measurement concept to pension assets and liabilities, concluding that difficulties are likely to arise in measuring pension liabilities at far value, owing to the absence of well-developed markets for such liabilities.

  19. Debate Regarding Measuring Accounting Value: Historical Cost against Fair Value

    OpenAIRE

    Victor Munteanu; Marilena Zuca

    2015-01-01

    The transition from historical cost to fair value represents an option with major implications in accounting, because it is a complex process that requires tuning to today’s trends of national and global economy. We can state that with all the advantages of using historical cost it has its limitations and it is” getting old”. That doesn’t mean that will be abandoned but substituted when it is needed with another value. At present, the lack of historical value is inconceivable; many practit...

  20. Debate Regarding Measuring Accounting Value: Historical Cost against Fair Value

    Directory of Open Access Journals (Sweden)

    Victor Munteanu

    2015-12-01

    Full Text Available The transition from historical cost to fair value represents an option with major implications in accounting, because it is a complex process that requires tuning to today’s trends of national and global economy. We can state that with all the advantages of using historical cost it has its limitations and it is” getting old”. That doesn’t mean that will be abandoned but substituted when it is needed with another value. At present, the lack of historical value is inconceivable; many practitioners consider it to be the best method to evaluate assets.

  1. Motivational beliefs, values, and goals.

    Science.gov (United States)

    Eccles, Jacquelynne S; Wigfield, Allan

    2002-01-01

    This chapter reviews the recent research on motivation, beliefs, values, and goals, focusing on developmental and educational psychology. The authors divide the chapter into four major sections: theories focused on expectancies for success (self-efficacy theory and control theory), theories focused on task value (theories focused on intrinsic motivation, self-determination, flow, interest, and goals), theories that integrate expectancies and values (attribution theory, the expectancy-value models of Eccles et al., Feather, and Heckhausen, and self-worth theory), and theories integrating motivation and cognition (social cognitive theories of self-regulation and motivation, the work by Winne & Marx, Borkowski et al., Pintrich et al., and theories of motivation and volition). The authors end the chapter with a discussion of how to integrate theories of self-regulation and expectancy-value models of motivation and suggest new directions for future research.

  2. The Constitutive Values of Science

    Directory of Open Access Journals (Sweden)

    Hugh Lacey

    1997-06-01

    Full Text Available Cognitive values are the characteristics that are constitutive of good theories, the criteria to which we appeal when choosing among competing theories. I argue that, in order to count as a cognitive value, a characteristic must be needed to explain actually made theory choices, and its cognitive significance must be well defended especially in view of considerations derived from the objective of science. A number of proposed objectives of science are entertained, and it is argued that adopting a par-ticular objective is dialectically intertwined with commitment to certain social values.Then, the ways in which science is, and is not value free is explored briefly, leading to the identification of a level of analysis where values may influence theory choice without causing paradox or threatening the impartiality of soundly-made scientific judgments.

  3. Replicator dynamics in value chains

    DEFF Research Database (Denmark)

    Cantner, Uwe; Savin, Ivan; Vannuccini, Simone

    2016-01-01

    The pure model of replicator dynamics though providing important insights in the evolution of markets has not found much of empirical support. This paper extends the model to the case of firms vertically integrated in value chains. We show that i) by taking value chains into account, the replicator...... dynamics may revert its effect. In these regressive developments of market selection, firms with low fitness expand because of being integrated with highly fit partners, and the other way around; ii) allowing partner's switching within a value chain illustrates that periods of instability in the early...... stage of industry life-cycle may be the result of an 'optimization' of partners within a value chain providing a novel and simple explanation to the evidence discussed by Mazzucato (1998); iii) there are distinct differences in the contribution to market selection between the layers of a value chain...

  4. God, Evil, and Infinite Value

    Directory of Open Access Journals (Sweden)

    Marshall Naylor

    2018-01-01

    Full Text Available Prominent approaches to the problems of evil assume that even if the Anselmian God exists, some worlds are better than others, all else being equal. But the assumptions that the Anselmian God exists and that some worlds are better than others cannot be true together. One description, by Mark Johnston and Georg Cantor, values God’s existence as exceeding any transfinite cardinal value. For any finite or infinite amount of goodness in any possible world, God’s value infinitely exceeds that amount. This conception is not obviously inconsistent with the Anselmian God. As a result, the prominent approaches to the problems of evil are mistaken. The elimination of evil does not, in fact, improve the value of any world as commonly thought. Permitting evil does not, in fact, diminish the value of any world as commonly thought.

  5. Facilities Management and Added Value

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2010-01-01

    Aim: This paper aims to present different models of the concept of the added value of Facilities Management (FM), including the FM Value Map, which forms the basis of research group in EuroFM, and to present some of the results of this research collaboration. Approach and methodology: The paper...... is based on literature reviews of the most influential journals within the academic fields of FM, Corporate Real Estate Management and Business to Business Marketing and discussions between participants of the research group working on a further exploration and testing of the FM Value Map. Conclusions......: The research shows a number of different definitions and focus points of Added Value of FM, dependent on the academic field and the area of application. The different research perspectives explored a holistic view on the added value of FM by the integration of an external market based view (with a focus...

  6. Analysing performance through value creation

    Directory of Open Access Journals (Sweden)

    Adrian TRIFAN

    2015-12-01

    Full Text Available This paper draws a parallel between measuring financial performance in 2 variants: the first one using data offered by accounting, which lays emphasis on maximizing profit, and the second one which aims to create value. The traditional approach to performance is based on some indicators from accounting data: ROI, ROE, EPS. The traditional management, based on analysing the data from accounting, has shown its limits, and a new approach is needed, based on creating value. The evaluation of value based performance tries to avoid the errors due to accounting data, by using other specific indicators: EVA, MVA, TSR, CVA. The main objective is shifted from maximizing the income to maximizing the value created for shareholders. The theoretical part is accompanied by a practical analysis regarding the creation of value and an analysis of the main indicators which evaluate this concept.

  7. Revelation and Innovation of Value

    DEFF Research Database (Denmark)

    Saghaug, Kristin Margrethe

    Kristin F. Saghaug’s Phd thesis investigates the interaction of revelatory theology, artistic creativity and small business owners in a business model innovation context. This project challenges mainstream business management’s concept of value and adds to the understanding of the innovation...... process through a pioneering conversation across different specialized domains. How can philosophical theology, namely, Paul Tillich’s theory of revelation, contribute to productive reflection on the innovation of value among small business owners in a business model innovation context? Empirical findings...... show that many of the business owners in this study try to balance between their personal values and economic values. A further investigation into this results in a model of innovation of value from a theological perspective in respect to business model innovation. It is the very understanding...

  8. Synthesis and biological activities of substituted N ...

    African Journals Online (AJOL)

    use

    2011-12-07

    Dec 7, 2011 ... hydroxyl radical (OH) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assays and the IC50 values ... good polydentate- chelating agents, which can form a ..... iron transport and storage due to various exogenous and.

  9. The Polyphony of Values and the Value of Polyphony

    DEFF Research Database (Denmark)

    Christensen, Lars Thøger; Morsing, Mette; Thyssen, Ole

    2015-01-01

    While human communication is inherently symbolic and thus potentially vague, ambiguous and polyphonic, there is a growing emphasis on certainty, accuracy and consistency in everything contemporary organizations say and do. Organizational messages about corporate values, in particular, are expected...

  10. Valuing Our Values: Conflicts Between Principles and Practice

    International Nuclear Information System (INIS)

    Sjoelander, Annika

    2003-01-01

    The strong attendance and support for this and previous years' VALDOR symposia provides evidence of a collective vision that new approaches are required for society to meet the challenges presented by complex decisions on risk. We are all exposed to doubts about the capacity of the (late-)modern society's structures and institutions to deal with such decisions. These doubts are interwoven with an apparent distrust of specialist roles in the decision making process, not only those that are played by experts and scientists, but also the roles of politicians and journalists. In general, one can say that we try to identify sources of conflict in decisions on risk, and that we try to find a 'better' way - a way that is both holistic and truly democratic, rather than fragmented and controlled by the balance of power between competing interest groups. To sum up, we find that several of the problems associated with the practice of valuing our values can be understood, at least in general terms, in relation to the way in which questions about values are framed as well as received. Despite the fact that we appear to know exactly what we mean when we talk about transparency and values, we are not at all 'experts' in handling values, whether as senders or receivers in the communication chain. There is a need for more mature contexts when it comes to valuing our values. From our perspective, it also seems important to understand better how to frame questions about values in ways that are not threatening to the individual. And, last but not least, it is important to acknowledge and build on existing good practice within specialist roles in the risk discourse, such as ways for exposing the judgements and uncertainties that are part of risk assessment and multi-attribute analysis

  11. Value Preferences of Social Workers.

    Science.gov (United States)

    Tartakovsky, Eugene; Walsh, Sophie D

    2018-04-01

    The current study examines value preferences of social workers in Israel. Using a theoretical framework of person-environment fit paradigm and theory of values, the study compared social workers (N = 641, mean age = 37.7 years, 91 percent female) with a representative sample of Israeli Jews (N = 1,600, mean age = 44.2, 52 percent female). Questionnaires included personal value preferences and sociodemographic variables (gender, age, education, religiosity, and immigrant status). Multivariate analysis of covariance showed that value preferences of social workers differed significantly from those of the general population. Analyses of covariance showed that social workers reported a higher preference for self-transcendence and a lower preference for conservation and self-enhancement values. Results have significance for the selection, training, and supervision of social workers. They suggest that it is important to assess to what extent selection processes for social workers are primarily recruiting social workers with shared values, thus creating an overly homogenous population of social workers. An understanding of personal value motivations can help social workers in their own process of self-development and growth, and to understand how the profession can fulfill their basic motivations.

  12. Personal values and value systems of humanities students and workers

    Directory of Open Access Journals (Sweden)

    Lucie Křeménková

    2015-01-01

    Full Text Available Problem: The aim of this paper is to analyze the value orientation of university students and workers in humanities and then determine possible differences between these groups in the context of branches of occupation, school results and gender. Methods: The sample consisted of 158 university students aged 19-24 years (mean age = 20.8 and 170 humanities workers aged 29-48 years (mean age=36.8. Respondents were divided into following groups: men (N = 72, women (N = 256, students’ school results A (N = 43, B (N = 47, C (N = 35, D (N = 29, E (N = 4 and worker´s branch of occupation: teachers in the kindergarten (N = 34, special education teachers (N = 32, high school teachers (N = 47, educational workers (N = 31 and civil servants (N = 26. We used a Rokeach Value Survey (RVS which is designed to measure two sets of values. One set is composed of 18 terminal values or desired end states of existence (e.g., an exciting life, national security, and the other set is composed of 18 instrumental values, or preferable modes of behavior (e.g., being ambitious, independent. Then, subjects are asked to rank order each value as to its importance as a guiding principle in their life. A 1 indicates the most important value and an 18 the least important. Scale responses are considered ordinal.Data were analyzed using SPSS. Results: We analyzed the preference of values depending on the gender. Pearson’s ?2 analyses indicated that men are significantly more (often „Effective Crusaders“ than women and women are significantly more (often „Virtuous Advocates“ than men, ?2 (3 = 13.817, p= .003, ?c = .205. After that we analyzed the preference of values depending on depending on the type of employment. Pearson’s ?2analyses indicated that students are significantly more (often „Virtuous Advocates“ than workers and workers are significantly more (often „Effective Crusaders“ and „Independent Maximizers“ than students, ?2 (3 = 61.414, p= .000, ?c

  13. Value-driven ERM: making ERM an engine for simultaneous value creation and value protection.

    Science.gov (United States)

    Celona, John; Driver, Jeffrey; Hall, Edward

    2011-01-01

    Enterprise risk management (ERM) began as an effort to integrate the historically disparate silos of risk management in organizations. More recently, as recognition has grown of the need to cover the upside risks in value creation (financial and otherwise), organizations and practitioners have been searching for the means to do this. Existing tools such as heat maps and risk registers are not adequate for this task. Instead, a conceptually new value-driven framework is needed to realize the promise of enterprise-wide coverage of all risks, for both value protection and value creation. The methodology of decision analysis provides the means of capturing systemic, correlated, and value-creation risks on the same basis as value protection risks and has been integrated into the value-driven approach to ERM described in this article. Stanford Hospital and Clinics Risk Consulting and Strategic Decisions Group have been working to apply this value-driven ERM at Stanford University Medical Center. © 2011 American Society for Healthcare Risk Management of the American Hospital Association.

  14. ECONOMIC VALUE ADDED AND MARKET VALUE ADDED - MODERN INDICATORS FOR ASSESSMENT THE FIRM’S VALUE

    Directory of Open Access Journals (Sweden)

    NICOLAE SICHIGEA

    2015-12-01

    Full Text Available The financial theory developed different categories of indicators - traditional and modern - in order to evaluate the firm’s value creation. The shareholders are directly interested by the value added in the company. The value creation is a complex process that implies correct decisions, common responsibility (managers and shareholders and actions towards an efficient and profitable activity. The traditional indicators of performance are not teoritically correlated with the the value creation and in these circumstances, should be used appropriate financial indicators in order to reflect the value of the company. Therefore, the modern indicators used in the value based management framework offer a greater flexibility and efficiency and represent a good alternative for companies. Such performance indicators used to measure the financial results correlated with shareholder wealth are the Economic Value Added (EVA, as a measure of internal performance and the Market Value Added (MVA as a measure of external performance of the company. Starting from the main deficiencies of the accounting indicators, the objective of this this study is to present the relationship between EVA and MVA and their implications on firms’valuation. Thus, the presentation and analysis of these indicators – EVA and MVA - will underline the main features, their correlations, and influence factors but also the main advantage and disadvantage of each indicator, which will enable the managers to make the correct choice and subsequently the best decision regarding the performance measures.

  15. The value of innovation under value-based pricing

    Science.gov (United States)

    Moreno, Santiago G.; Ray, Joshua A.

    2016-01-01

    Objective The role of cost-effectiveness analysis (CEA) in incentivizing innovation is controversial. Critics of CEA argue that its use for pricing purposes disregards the ‘value of innovation’ reflected in new drug development, whereas supporters of CEA highlight that the value of innovation is already accounted for. Our objective in this article is to outline the limitations of the conventional CEA approach, while proposing an alternative method of evaluation that captures the value of innovation more accurately. Method The adoption of a new drug benefits present and future patients (with cost implications) for as long as the drug is part of clinical practice. Incidence patients and off-patent prices are identified as two key missing features preventing the conventional CEA approach from capturing 1) benefit to future patients and 2) future savings from off-patent prices. The proposed CEA approach incorporates these two features to derive the total lifetime value of an innovative drug (i.e., the value of innovation). Results The conventional CEA approach tends to underestimate the value of innovative drugs by disregarding the benefit to future patients and savings from off-patent prices. As a result, innovative drugs are underpriced, only allowing manufacturers to capture approximately 15% of the total value of innovation during the patent protection period. In addition to including the incidence population and off-patent price, the alternative approach proposes pricing new drugs by first negotiating the share of value of innovation to be appropriated by the manufacturer (>15%?) and payer (price that satisfies this condition. Conclusion We argue for a modification to the conventional CEA approach that integrates the total lifetime value of innovative drugs into CEA, by taking into account off-patent pricing and future patients. The proposed approach derives a price that allows manufacturers to capture an agreed share of this value, thereby incentivizing

  16. The value of innovation under value-based pricing.

    Science.gov (United States)

    Moreno, Santiago G; Ray, Joshua A

    2016-01-01

    The role of cost-effectiveness analysis (CEA) in incentivizing innovation is controversial. Critics of CEA argue that its use for pricing purposes disregards the 'value of innovation' reflected in new drug development, whereas supporters of CEA highlight that the value of innovation is already accounted for. Our objective in this article is to outline the limitations of the conventional CEA approach, while proposing an alternative method of evaluation that captures the value of innovation more accurately. The adoption of a new drug benefits present and future patients (with cost implications) for as long as the drug is part of clinical practice. Incidence patients and off-patent prices are identified as two key missing features preventing the conventional CEA approach from capturing 1) benefit to future patients and 2) future savings from off-patent prices. The proposed CEA approach incorporates these two features to derive the total lifetime value of an innovative drug (i.e., the value of innovation). The conventional CEA approach tends to underestimate the value of innovative drugs by disregarding the benefit to future patients and savings from off-patent prices. As a result, innovative drugs are underpriced, only allowing manufacturers to capture approximately 15% of the total value of innovation during the patent protection period. In addition to including the incidence population and off-patent price, the alternative approach proposes pricing new drugs by first negotiating the share of value of innovation to be appropriated by the manufacturer (>15%?) and payer (price that satisfies this condition. We argue for a modification to the conventional CEA approach that integrates the total lifetime value of innovative drugs into CEA, by taking into account off-patent pricing and future patients. The proposed approach derives a price that allows manufacturers to capture an agreed share of this value, thereby incentivizing innovation, while supporting health

  17. Applying the Expectancy-Value Model to understand health values.

    Science.gov (United States)

    Zhang, Xu-Hao; Xie, Feng; Wee, Hwee-Lin; Thumboo, Julian; Li, Shu-Chuen

    2008-03-01

    Expectancy-Value Model (EVM) is the most structured model in psychology to predict attitudes by measuring attitudinal attributes (AAs) and relevant external variables. Because health value could be categorized as attitude, we aimed to apply EVM to explore its usefulness in explaining variances in health values and investigate underlying factors. Focus group discussion was carried out to identify the most common and significant AAs toward 5 different health states (coded as 11111, 11121, 21221, 32323, and 33333 in EuroQol Five-Dimension (EQ-5D) descriptive system). AAs were measured in a sum of multiplications of subjective probability (expectancy) and perceived value of attributes with 7-point Likert scales. Health values were measured using visual analog scales (VAS, range 0-1). External variables (age, sex, ethnicity, education, housing, marital status, and concurrent chronic diseases) were also incorporated into survey questionnaire distributed by convenience sampling among eligible respondents. Univariate analyses were used to identify external variables causing significant differences in VAS. Multiple linear regression model (MLR) and hierarchical regression model were used to investigate the explanatory power of AAs and possible significant external variable(s) separately or in combination, for each individual health state and a mixed scenario of five states, respectively. Four AAs were identified, namely, "worsening your quality of life in terms of health" (WQoL), "adding a burden to your family" (BTF), "making you less independent" (MLI) and "unable to work or study" (UWS). Data were analyzed based on 232 respondents (mean [SD] age: 27.7 [15.07] years, 49.1% female). Health values varied significantly across 5 health states, ranging from 0.12 (33333) to 0.97 (11111). With no significant external variables identified, EVM explained up to 62% of the variances in health values across 5 health states. The explanatory power of 4 AAs were found to be between 13

  18. FAIR VALUE: UTILITY AND LIMITS

    Directory of Open Access Journals (Sweden)

    Valentin Gabriel Cristea

    2015-05-01

    Full Text Available This paper presents the utility and the limits of the fair value. We believe that any new product must be tried and tested before being imposed on the market and must be accepted by all potential users and those who will be affected, directly or indirectly and its advantages, disadvantages, risks, its cost must be predetermined and analyzed in a comprehensive and objective.We ask: Do financial statements at fair value meet users' expectations? The requirement to use fair value pricing model that was carrying was not accompanied by a parallel examination of its impact on the presentation of accounts.

  19. ACADEMIC ADVISORS: VALUES EDUCATED LEADERS

    Directory of Open Access Journals (Sweden)

    Brizeida Mijares

    2008-07-01

    Full Text Available The purpose of this article is to study the academic advisors’ profile from the attitudes in the learning process view point, being the center of which the need that as an educator, the advisor has to be a leader educated in values. The research was documental, according to the theoretical contributions of Arana and Batista (2006,  Ortega and Minguez (2001 and Denis (2000, among others. It is concluded that an academic advisor in values allows individual and collective trasnformation and an education without values as its center, it is a hollow and useless education.

  20. Value Creation in International Business

    DEFF Research Database (Denmark)

    is a pioneering two volume work intended to provoke theoretical and empirical development in International Business research. Moreover, it is intended as a bridge between concepts derived from general business firm-level research agendas such as value creation and business model, and internationalization......The edited collection brings into focus the meanings, interpretations and the process of value creation in international business. Exploring value creation in the context of emerging and developed economies, Volume 2 takes the perspective of small and medium sized enterprises and examines various...

  1. Value Creation in Cryptocurrency Networks

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    2015-01-01

    Cryptocurrency networks have given birth to a diversity of start-ups and attracted a huge influx of venture capital to invest in these start-ups for creating and capturing value within and between such networks. Synthesizing strategic management and information systems (IS) literature, this study...... advances a unified theoretical framework for identifying and investigating how cryptocurrency companies configure value through digital business models. This framework is then employed, via multiple case studies, to examine digital business models of companies within the bitcoin network. Findings suggest...... on value configurations and digital businesses models within the emerging and increasingly pervasive domain of cryptocurrency networks....

  2. Value of travel time savings

    DEFF Research Database (Denmark)

    Le Masurier, P.; Polak, J.; Pawlak, Janet

    2015-01-01

    A team of specialist market researchers and Value of Time experts comprising members from SYSTRA, Imperial College London and the Technical University of Denmark has conducted a formal audit and peer review of research undertaken by Arup/ITS Leeds/Accent to derive Value of Travel Time Savings...... Preference (RP) models that were used to derive final Values of Travel Time (VTT). This report contains the findings of our audit and peer review of the procedures adopted by the research team during data collection of the three surveys (SP, RP and Employers Surveys); a peer review of the reported approach...

  3. Exploring Value-Added Options

    Science.gov (United States)

    Bob Smith; Philip A. Araman

    1997-01-01

    This paper looks at various opportunities for sawmills to add value to rough sawn lumber. The paper discusses edge-glued panels and blanks, mouldings and millwork, niche market opportunities, and timber bridge members.

  4. ISO 14001 EMS VALUE PROPOSITION

    International Nuclear Information System (INIS)

    BRIGGS, S.L.K.

    2001-01-01

    The objective of this report is to identify business opportunities and value for Battelle Organizations to undertake IS0 14001 Environmental Management System Implementation and registration to the international standard as a corporate strategic initiative

  5. Dietary Reference Values for choline

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives Dietary Reference Values (DRVs) for choline. In this Opinion, the Panel considers dietary choline including choline compounds (e.g. glycerophosphocholine, phosphocholine...

  6. The value of neonatal autopsy.

    LENUS (Irish Health Repository)

    Hickey, Leah

    2012-01-01

    Neonatal autopsy rates were in decline internationally at the end of the last century. Our objective was to assess the current value of neonatal autopsy in providing additional information to families and healthcare professionals.

  7. Value Modifier Public Use File

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Center for Medicare (CM) has created a standard analytical file intended to promote transparency. For each Value Modifier performance year, CM will publish a...

  8. Religiosity and Values in Romania

    Directory of Open Access Journals (Sweden)

    Sorin Dan ŞANDOR

    2008-02-01

    Full Text Available In Romania the state supports religion. The main reason is claimed to be the fact that religion will improve the shared values (moral, social, economic or political of our society. Based on the data from the Public Opinion Barometer November 2005 (which included the questions from The World Values Survey 2005 this study explores the relationship between religiosity and work ethic, moral values and tolerance; as well as the ways in which religiosity affects political and gender-based attitudes. Regarding most of the values included a weak but significant relationship was found. A poorer work and general ethic, attitudes towards women and homosexuals or the preference for a more authoritarian regime are the most disquieting findings.

  9. In Search of Public Value

    DEFF Research Database (Denmark)

    Pedersen, Dorthe

    This paper takes it point of departure in the vision of educating public leaders and managers with the ability to create public value in networked governance structure. The purpose of the paper it to revise this vision by unpacking the notion of public value in contemporary governance and discuss...... the implications for the public leadership and public leadership programs. Drawing on insights from sociology of law and governmentality a set of key tensions inherent in public value discourse are identified as the diagnostic impetus to consider the somewhat excessive leadership figure put forward...... in the literature. The paper shows that the notion of public value is rather contested and that it imply a certain kind of hybridization of public administration into opposing identity spheres. Instead of forming af 'whole system' as suggested in the literature, the hybridization implicate an ongoing suspension...

  10. Hospital Value-Based Purchasing

    Data.gov (United States)

    U.S. Department of Health & Human Services — Hospital Value-Based Purchasing (VBP) is part of the Centers for Medicare and Medicaid Services (CMS) long-standing effort to link Medicares payment system to a...

  11. Cultural values and international migration

    Directory of Open Access Journals (Sweden)

    Miryam Rodríguez Monter

    2009-05-01

    Full Text Available Immigration is one of the most controversial social issues debated nowadays. It is an undeniable fact that the phenomenon is lived in Europe with concern because of its consequences. People who live and coexist in Europe represent a huge cultural variety. Therefore, social and cultural gaps that can affect the basic values of the western societies seem to be inevitable due to the dimensions of the current migration phenomenon. The present studies are based on the European Social Survey Questionnaire (2002, and the Portrait Values Questionnaire (Schwartz, 1992, 2001 and focuses on the relevance of cultural values to explain the acceptance or rejection of the immigrant.. Finally, we emphasize the importance of cultural values -like Harmony or Egalitarianism- for any initiative or social policy which aimes at reducing the problems concerning inmigration in the European context.

  12. OFFSHORING FOR SUSTAINABLE VALUE MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Thaddeus Oforegbunam Ebiringa

    2014-05-01

    Full Text Available This paper evaluates offshoring as a strategic value management initiative using Cadbury Nigeria Plc as a case study. Through offshoring risks associated with inventory holding are hedged. A comparative analysis of in-house and offshored cost profiles as well as critical risk factors that affect firm value are evaluated. The result shows that offshoring led to immediate costs saving, freeing of funds previously held in inventory for other working capital investments as well as profitability for vendors. However, aside financial benefits to partners, it leads to increased stakeholders awareness, shared values, partnerships, teamwork and risk mitigation. It therefore follows that for sustainability of financial benefits of offshoring, concerted effort must be made by partners to ensure that critical drivers of value management are not compromised.

  13. Values, Evidence, and Mastery Learning.

    Science.gov (United States)

    Anderson, Lorin W.; Burns, Robert B.

    1987-01-01

    Responds to R. Slavin's best-evidence synthesis of research on mastery learning. Contends that at the heart of decisions about education are value judgments about how the mind should be cultivated and for what goal. (RB)

  14. Value system for distruptive innovation

    DEFF Research Database (Denmark)

    Li, Jizhen; Zhang, Si; Hu, Yimei

    After reviewing the theory of disruptive innovation, this paper forms a new framework for analyzing disruptive innovation from the perspective of value system, which suggests that the technology per se is the value source, industrial Ecosystem is the carrier, business model is the instrument...... and the market trajectory is the terminal, through the coordination of the elements in the value system the success of firms in disruptive innovation could be obtained and sustained. In other words, with the understanding of how value system works in disruptive innovation, the failure of incumbent firms may...... hopefully find its root. According to the framework, it summarizes different types of disruption that LED brings to traditional lighting industry in Guangdong Province, and proposes policy recommendations to accelerate the development of LED lighting industry in Guangdong Province....

  15. Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa.

    Science.gov (United States)

    Ahmad, Ijaz; Chen, Shilin; Peng, Yong; Chen, Sibao; Xu, Lijia

    2008-02-01

    Phytochemical investigations on the ethyl acetate-soluble fraction of the whole plant of Buddleja crispa led to the isolation of the iridoids 1-7. Compound 2 displayed significant inhibitory potential against enzyme lipoxygenase in a concentration-dependant fashion with IC(50) value of 39.7 +/- 0.02microM, along with DPPH radical scavenging activity with IC(50) value 0.638 mM.

  16. Synthesis and antiproliferative activity of diethyl 5- acetyl-4-methyl- 6 ...

    African Journals Online (AJOL)

    Diethyl 5-acetyl-4-methyl-6-(2-fluorophenylimino)-6H-thiopyran-2,3-dicarboxylate (3TM) was synthesized and the antiproliferative activity of 3TM is reported here. Compound 3TM inhibits the growth of human colon cancer HCT-15 with an IC50 value of 4.5 μM and breast cancer MCF-7 with an IC50 value of 7 μM in a ...

  17. Truth Values of Quantum Phenomena

    Science.gov (United States)

    Bolotin, Arkady

    2018-04-01

    In the paper, the idea of describing not-yet-verified properties of quantum objects with logical many-valuedness is scrutinized. As it is argued, to promote such an idea, the following two foundational problems of many-valued quantum logic must be decided: the problem of choosing a proper system of many-valued logic and the problem of the emergence of bivalence from logical many-valuedness. Difficulties accompanying solutions of these problems are discussed.

  18. Accounting for Fair Value Headging

    OpenAIRE

    Botea Elena Mihaela; Stanila Oana Georgiana; SSahlian Daniela Nicoleta

    2010-01-01

    The derivatives appearance was generated by the discovery of new ways to limit and manage current activity risks. Derivatives couldn’t hedge any type of risk. Derivative operations can be used to hedge: interest rate risks, foreign currency exchange rate risks, credit risks. Derivatives used to hedge these risks can be handled to cover fair value exposure, cash flow exposure and exposure to changes in the value of a net investment in a foreign operation. The hedging accounting roll is to prot...

  19. Theoretical value of psychological testing.

    Science.gov (United States)

    Shapiro, David

    2012-01-01

    Apart from their diagnostic value, psychological tests, especially the Rorschach test, have an important theoretical value for understanding psychopathology. They present a picture of a living person, in contrast to a picture of forces and agencies within the person. This rests on 2 advantages of tests over the usual psychiatric and psychoanalytic interviews: Tests are ahistorical and they present information primarily of a formal kind.

  20. Standard and Null Weak Values

    OpenAIRE

    Zilberberg, Oded; Romito, Alessandro; Gefen, Yuval

    2013-01-01

    Weak value (WV) is a quantum mechanical measurement protocol, proposed by Aharonov, Albert, and Vaidman. It consists of a weak measurement, which is weighed in, conditional on the outcome of a later, strong measurement. Here we define another two-step measurement protocol, null weak value (NVW), and point out its advantages as compared to WV. We present two alternative derivations of NWVs and compare them to the corresponding derivations of WVs.

  1. The value of service reliability

    OpenAIRE

    Benezech , Vincent; Coulombel , Nicolas

    2013-01-01

    International audience; This paper studies the impact of service frequency and reliability on the choice of departure time and the travel cost of transit users. When the user has (α, β, γ) scheduling preferences, we show that the optimal head start decreases with service reliability, as expected. It does not necessarily decrease with service frequency, however. We derive the value of service headway (VoSH) and the value of service reliability (VoSR), which measure the marginal effect on the e...

  2. Work values and organizational commitment.

    Science.gov (United States)

    Kidron, A

    1978-06-01

    Dubin, Champoux and Porter (1975) found a strong relationship between central life interests of workers and their commitment to the organization. This paper extends their findings by investigating the relationship between work values, defined as the Protestant Ethic of the worker, and commitment to the organization. A distinction is made between moral and calculative commitment, and it is shown that work values are related more to moral than calculative involvement.

  3. Value analysis in organizational context

    OpenAIRE

    Marques, Carlos Alberto Alves

    1991-01-01

    Tese de doutoramento apresentada à Universidade de Brabant, Tilburg In the last two decades there has been a significant development of organizational culture theories inside organizational psychology, which have been largely divulged among managers who have adopted them in their everyday language. Inside those theories one concept occupies a "central role": the concept of value (v.g. Jones, 1983; Smircish, 1983; Schein, 1985). In this book we present a study looking for the role of values...

  4. ARCHITECTURAL CONCEPTS FOR VALUE CHAINS

    OpenAIRE

    A.C. Janse van Rensburg

    2012-01-01

    ENGLISH ABSTRACT:The Porter Value Chain has been widely adopted by the business community as a mechanism to understand and comprehend complexity in business environments, with the ultimate goal of structuring the business to maximize its competitive advantage. Implementing the Value Chain is not easy: a number of organizations can testify to their failure to derive any benefits at all from this concept. To overcome this problem, an approach is presented to assist the organization in ...

  5. Clarifying values: an updated review

    Science.gov (United States)

    2013-01-01

    Background Consensus guidelines have recommended that decision aids include a process for helping patients clarify their values. We sought to examine the theoretical and empirical evidence related to the use of values clarification methods in patient decision aids. Methods Building on the International Patient Decision Aid Standards (IPDAS) Collaboration’s 2005 review of values clarification methods in decision aids, we convened a multi-disciplinary expert group to examine key definitions, decision-making process theories, and empirical evidence about the effects of values clarification methods in decision aids. To summarize the current state of theory and evidence about the role of values clarification methods in decision aids, we undertook a process of evidence review and summary. Results Values clarification methods (VCMs) are best defined as methods to help patients think about the desirability of options or attributes of options within a specific decision context, in order to identify which option he/she prefers. Several decision making process theories were identified that can inform the design of values clarification methods, but no single “best” practice for how such methods should be constructed was determined. Our evidence review found that existing VCMs were used for a variety of different decisions, rarely referenced underlying theory for their design, but generally were well described in regard to their development process. Listing the pros and cons of a decision was the most common method used. The 13 trials that compared decision support with or without VCMs reached mixed results: some found that VCMs improved some decision-making processes, while others found no effect. Conclusions Values clarification methods may improve decision-making processes and potentially more distal outcomes. However, the small number of evaluations of VCMs and, where evaluations exist, the heterogeneity in outcome measures makes it difficult to determine their

  6. Forest ecosystem services: Cultural values

    Science.gov (United States)

    Melissa M. Kreye; Damian C. Adams; Ramesh Ghimire; Wayde Morse; Taylor Stein; J. M. Bowker

    2017-01-01

    How we define “culture” and societal well-being related to culture depends heavily on who is looking at it, but culture can be generally described as “the customs and beliefs of a particular group of people that are used to express their collectively held values” (Soulbury Commission 2012). In the context of forests, culturally derived norms, beliefs, and values help...

  7. From value chain to value constellation: designing interactive strategy.

    Science.gov (United States)

    Normann, R; Ramírez, R

    1993-01-01

    In today's fast-changing competitive environment, strategy is no longer a matter of positioning a fixed set of activities along that old industrial model, the value chain. Successful companies increasingly do not just add value, they reinvent it. The key strategic task is to reconfigure roles and relationships among a constellation of actors--suppliers, partners, customers--in order to mobilize the creation of value by new combinations of players. What is so different about this new logic of value? It breaks down the distinction between products and services and combines them into activity-based "offerings" from which customers can create value for themselves. But as potential offerings grow more complex, so do the relationships necessary to create them. As a result, a company's strategic task becomes the ongoing reconfiguration and integration of its competencies and customers. The authors provide three illustrations of these new rules of strategy. IKEA has blossomed into the world's largest retailer of home furnishings by redefining the relationships and organizational practices of the furniture business. Danish pharmacies and their national association have used the opportunity of health care reform to reconfigure their relationships with customers, doctors, hospitals, drug manufacturers, and with Danish and international health organizations to enlarge their role, competencies, and profits. French public-service concessionaires have mastered the art of conducting a creative dialogue between their customers--local governments in France and around the world--and a perpetually expanding set of infrastructure competencies.

  8. The relative value of growth.

    Science.gov (United States)

    Mass, Nathaniel J

    2005-04-01

    Most executives would say that adding a point of growth and gaining a point of operating-profit margin contribute about equally to shareholder value. Margin improvements hit the bottom line immediately, while growth compounds value over time. But the reality is that the two are rarely equivalent. Growth often is far more valuable than managers think. For some companies, convincing the market that they can grow by just one additional percentage point can be worth six, seven, or even ten points of margin improvement. This article presents a new strategic metric, called the relative value of growth (RVG), which gives managers a clear picture of how growth projects and margin improvement initiatives affect shareholder value. Using basic balance sheet and income sheet data, managers can determine their companies' RVGs, as well as those of their competitors. Calculating RVGs gives managers insights into which corporate strategies are working to deliver value and whether their companies are pulling the most powerful value-creation levers. The author examines a number of well-known companies and explains what their RVG numbers say about their strategies. He reviews the unspoken assumption that growth and profits are incompatible over the long term and shows that a fair number of companies are effective at delivering both. Finally, he explains how managers can use the RVG framework to help them define strategies that balance growth and profitability at both the corporate and business unit levels.

  9. Lifetime value in business process

    Directory of Open Access Journals (Sweden)

    Martin Souček

    2011-01-01

    Full Text Available The paper focuses on lifetime value assessment and its implementation and application in business processes. The lifetime value is closely connected to customer relationship management. The paper presents results of three consecutive researches devoted to issues of customer relationship management. The first two from 2008 and 2010 were conducted as quantitative ones; the one from 2009 had qualitative nature. The respondents were representatives of particular companies. The means for data collection was provided by ReLa system. We will focus on individual attributes of lifetime value of a customer, and relate them to approaches of authors mentioned in introduction. Based on the qualitative research data, the paper focuses on individual customer lifetime value parameters. These parameters include: the cost to the customer relationship acquisition and maintenance, profit generated from a particular customer, customer awareness value, the level of preparedness to adopt new products, the value of references and customer loyalty level. For each of these parameters, the paper provides specific recommendations. Moreover, it is possible to learn about the nature of these parameter assessments in the Czech environment.

  10. Chinese values, health and nursing.

    Science.gov (United States)

    Chen, Y C

    2001-10-01

    To describe the roots of Chinese values, beliefs and the concept of health, and to illustrate how these ways have influenced the development of health care and nursing among Chinese in the Republic of China (ROC) and the People's Republic of China (PRC). Scope. Based on the literature and direct observation in the PRC and ROC, this is an introduction to Chinese philosophies, religion, basic beliefs, and values with a special meaning for health and nursing. Chinese philosophies and religion include Confucian principles, Taoism, theory of "Yin" and "Yang", and Buddhism. Beliefs and values include the way of education, practice of acupuncture, herbal treatments and diet therapy. How people value traditional Chinese medicine in combination with western science, and the future direction of nursing and nursing inquiry are also briefly addressed. Chinese philosophies and religions strongly influence the Chinese way of living and thinking about health and health care. Nurses must combine information about culture with clinical assessment of the patient to provide cultural sensitive care. A better way may be to combine both western and Chinese values into the Chinese health care system by negotiating between the traditional values while at the same time, respecting an individual's choice. The foundation of China's philosophical and aesthetic tradition, in combination with western science is important to the future advancement of nursing research that will be beneficial to the Republics, Asia, and the world.

  11. Human rights values or cultural values? Pursuing values to maintain positive discipline in multicultural schools

    Directory of Open Access Journals (Sweden)

    Petro du Preez

    2010-01-01

    Full Text Available Discussions on discipline in education often accentuate corporal punishment or measures to infuse moral fibre. In addition, many authors argue that inculcating a particular value system can promote discipline in schools. This could however be profoundly problematic in the light of the Constitution. We argue that positive discipline in multicultural school environments needs to be based in part on human rights values that are neither solely universally interpreted nor particularistically interpreted. We report on the data generated at a research workshop held as the final dissemination process of a four-year international research project entitled "Understanding human rights through different belief systems: intercultural and interreligious dialogue". Dialogue was chosen as a form of data gathering since it is more spontaneous than conventional questioning techniques and can thus generate more naturally occurring data to strengthen the outcomes of the project. It appears that some teachers believe discipline can only be maintained through the elevation of cultural values (particularism. We argue that schools should start negotiating, at the most basic level, the values, including emancipatory, human rights values, and cultural values, which could underpin positive discipline in multicultural schools. Drawing solely on cultural values is not only unlikely to solve the problem of discipline, but could also undermine the efforts to transform our diverse, democratic society.

  12. Likely values of the Higgs vacuum expectation value

    International Nuclear Information System (INIS)

    Donoghue, John F.; Dutta, Koushik; Ross, Andreas; Tegmark, Max

    2010-01-01

    We make an estimate of the likelihood function for the Higgs vacuum expectation value (vev) by imposing anthropic constraints on the existence of atoms while allowing the other parameters of the standard model to also be variable. We argue that the most important extra ingredients are the Yukawa couplings, and for the intrinsic distribution of Yukawa couplings we use the scale-invariant distribution which is favored phenomenologically. The result is successful phenomenologically, favoring values close to the observed vev. We also discuss modifications that can change these conclusions. Our work supports the hypothesis that the anthropic constraints could be the origin of the small Higgs vev.

  13. Value of the radiolabelled GLP-1 receptor antagonist exendin(9-39) for targeting of GLP-1 receptor-expressing pancreatic tissues in mice and humans

    International Nuclear Information System (INIS)

    Waser, Beatrice; Reubi, Jean Claude

    2011-01-01

    Radiolabelled glucagon-like peptide 1 (GLP-1) receptor agonists have recently been shown to successfully image benign insulinomas in patients. Moreover, it was recently reported that antagonist tracers were superior to agonist tracers for somatostatin and gastrin-releasing peptide receptor targeting of tumours. The present preclinical study determines therefore the value of an established GLP-1 receptor antagonist for the in vitro visualization of GLP-1 receptor-expressing tissues in mice and humans. Receptor autoradiography studies with 125 I-GLP-1(7-36)amide agonist or 125 I-Bolton-Hunter-exendin(9-39) antagonist radioligands were performed in mice pancreas and insulinomas as well as in human insulinomas; competition experiments were performed in the presence of increasing concentration of GLP-1(7-36)amide or exendin(9-39). The antagonist 125 I-Bolton-Hunter-exendin(9-39) labels mouse pancreatic β-cells and mouse insulinomas, but it does not label human pancreatic β-cells and insulinomas. High affinity displacement (IC 50 approximately 2 nM) is observed in mouse β-cells and insulinomas with either the exendin(9-39) antagonist or GLP-1(7-36)amide agonist. For comparison, the agonist 125 I-GLP-1(7-36)amide intensively labels mouse pancreatic β-cells, mouse insulinoma and human insulinomas; high affinity displacement is observed for the GLP-1(7-36)amide in all tissues; however, a 5 and 20 times lower affinity is found for exendin(9-39) in the mouse and human tissues, respectively. This study reports a species-dependent behaviour of the GLP-1 receptor antagonist exendin(9-39) that can optimally target GLP-1 receptors in mice but not in human tissue. Due to its overly low binding affinity, this antagonist is an inadequate targeting agent for human GLP-1 receptor-expressing tissues, as opposed to the GLP-1 receptor agonist, GLP-1(7-36)amide. (orig.)

  14. Overstating values: medical facts, diverse values, bioethics and values-based medicine.

    Science.gov (United States)

    Parker, Malcolm

    2013-02-01

    Fulford has argued that (1) the medical concepts illness, disease and dysfunction are inescapably evaluative terms, (2) illness is conceptually prior to disease, and (3) a model conforming to (2) has greater explanatory power and practical utility than the conventional value-free medical model. This 'reverse' model employs Hare's distinction between description and evaluation, and the sliding relationship between descriptive and evaluative meaning. Fulford's derivative 'Values Based Medicine' (VBM) readjusts the imbalance between the predominance of facts over values in medicine. VBM allegedly responds to the increased choices made available by, inter alia, the progress of medical science itself. VBM attributes appropriate status to evaluative meaning, where strong consensus about descriptive meaning is lacking. According to Fulford, quasi-legal bioethics, while it can be retained as a kind of deliberative framework, is outcome-based and pursues 'the right answer', while VBM approximates a democratic, process-oriented method for dealing with diverse values, in partnership with necessary contributions from evidence-based medicine (EBM). I support the non-cognitivist underpinnings of VBM, and its emphasis on the importance of values in medicine. But VBM overstates the complexity and diversity of values, misrepresents EBM and VBM as responses to scientific and evaluative complexity, and mistakenly depicts 'quasi-legal bioethics' as a space of settled descriptive meaning. Bioethical reasoning can expose strategies that attempt to reduce authentic values to scientific facts, illustrating that VBM provides no advantage over bioethics in delineating the connections between facts and values in medicine. © 2011 Blackwell Publishing Ltd.

  15. THE VALUE-BASED MANAGEMENT APPROACH: FROM THE SHAREHOLDER VALUE TO THE STAKEHOLDER VALUE

    OpenAIRE

    VALENTIN MUNTEANU; DOINA DANAIATA; LUMINITA HURBEAN; ALICE BERGLER

    2012-01-01

    The ongoing discussion about the adequate management form and the purpose of organizations in the contemporary postmodern society have once again gained in importance and interest after the financial crises of 2008. Different management concepts have been developed throughout the time, which propose objectives for organizations and thus managerial goals, activities and decision making. Considering the value based management approach and the stakeholder theory, we propose a shift in the value ...

  16. Antioxidant and Cytotoxic Effects of Crude Extract, Fractions and 4-Nerolidylcathecol from Aerial Parts of Pothomorphe umbellata L. (Piperaceae

    Directory of Open Access Journals (Sweden)

    Andrey P. Lopes

    2013-01-01

    Full Text Available The crude ethanolic extract from aerial parts of Pothomorphe umbellata L. (Piperaceae and fractions obtained by partitions sequentially among water-methanol, methylene chloride, and ethyl acetate, as well as the major constituent, 4-nerolidylcatechol, were, respectively, evaluated and evidenced for antioxidant and cytotoxic effects through fluorometric microplate and microculture tetrazolium assays in HL-60 cells. The crude ethanolic extract demonstrated the preeminent antioxidant activity (IC50=1.2 μg/mL against exogenous cytoplasmic reactive oxygen species, followed by the water-methanolic (IC50=4.5 μg/mL, methylene chloride (IC50=5.9 μg/mL, ethyl acetate (IC50=8.0 μg/mL, 4-nerolidylcatechol (IC50=8.6 μg/mL, and the sterol fractions (IC50>12.5 μg/mL. Vitamin C, the positive control used in this assay, presented IC50 value equivalent to 1.7 μg/mL. 4-Nerolidylcatechol (IC50=0.4 μg/mL and methylene chloride fraction (IC50=2.3 μg/mL presented considerable cytotoxicity probably because of the presence of an o-quinone, an auto-oxidation by product of the catechol. Polar compounds, present in the ethanol extract, appear to increase the solubility and stability of the major active constituent, acting synergistically with 4-nerolidylcatechol, improving its pharmacokinetic parameters and increasing significantly its antioxidant activity which, in turn, suggests that the aqueous-ethanolic extract, used in folklore medicine, is safe and effective.

  17. Group Decisions in Value Management

    Directory of Open Access Journals (Sweden)

    Christiono Utomo

    2015-04-01

    Full Text Available This research deals with a technique to expedite group decision making during the selection of technical solutions for value management process. Selection of a solution from a set of alternatives is facilitated by evaluating using multicriteria decision making techniques. During the process, every possible solution is rated on criteria of function and cost. Function deals more with quality than with quantity, and cost can be calculated based on the theoretical time value of money. Decision-making techniques based on satisfying games are applied to determine the relative function and cost of solutions and hence their relative value. The functions were determined by function analysis system technique. Analytical hierarchy process was applied to decision making and life-cycle cost analysis were used to calculate cost. Cooperative decision making was shown to consist of identifying agreement options, analyzing, and forming coalitions. The objective was attained using the satisfying game model as a basis for two main preferences. The model will improve the value of decision regarding design. It further emphasizes the importance of performance evaluation in the design process and value analysis. The result of the implementation, when applied to the selection of a building wall system, demonstrates a process of selecting the most valuable technical solution as the best-fit option for all decision makers. This work is relevant to group decision making and negotiation, as it aims to provide a framework to support negotiation in design activity.

  18. Education for values and bioethics.

    Science.gov (United States)

    Nunes, Rui; Duarte, Ivone; Santos, Cristina; Rego, Guilhermina

    2015-01-01

    "Education for Values and Bioethics" is a project which aims to help the student to build his/her personal ethics. It was addressed to ninth grade students (mean age 14) who frequented public education in all schools of the City of Porto, Portugal-EU in 2010-2013 (N-1164). This research and action project intended to promote the acquisition of knowledge in the following areas: interpersonal relationships, human rights, responsible sexuality, health, environment and sustainable development, preservation of public property, culture, financial education, social innovation and ethical education for work. The students were asked to answer to a knowledge questionnaire on bioethics. To assess the values it was used Leonard Gordon's Survey of Personal Values and Survey of Interpersonal Values. The results of this study show that the project contributes to an increase of knowledge in the area of bioethics. Also the students enrolled in the program showed a development with regards the acquisition of the basic values of pluralistic societies. It is also suggested that this general knowledge on bioethics could be especially helpful to students that want a career in health sciences.

  19. Active inference and epistemic value.

    Science.gov (United States)

    Friston, Karl; Rigoli, Francesco; Ognibene, Dimitri; Mathys, Christoph; Fitzgerald, Thomas; Pezzulo, Giovanni

    2015-01-01

    We offer a formal treatment of choice behavior based on the premise that agents minimize the expected free energy of future outcomes. Crucially, the negative free energy or quality of a policy can be decomposed into extrinsic and epistemic (or intrinsic) value. Minimizing expected free energy is therefore equivalent to maximizing extrinsic value or expected utility (defined in terms of prior preferences or goals), while maximizing information gain or intrinsic value (or reducing uncertainty about the causes of valuable outcomes). The resulting scheme resolves the exploration-exploitation dilemma: Epistemic value is maximized until there is no further information gain, after which exploitation is assured through maximization of extrinsic value. This is formally consistent with the Infomax principle, generalizing formulations of active vision based upon salience (Bayesian surprise) and optimal decisions based on expected utility and risk-sensitive (Kullback-Leibler) control. Furthermore, as with previous active inference formulations of discrete (Markovian) problems, ad hoc softmax parameters become the expected (Bayes-optimal) precision of beliefs about, or confidence in, policies. This article focuses on the basic theory, illustrating the ideas with simulations. A key aspect of these simulations is the similarity between precision updates and dopaminergic discharges observed in conditioning paradigms.

  20. Professional values, aesthetic values, and the ends of trade.

    Science.gov (United States)

    Edgar, Andrew

    2011-05-01

    Professionalism is initially understood as a historical process, through which certain commercial services sought to improve their social status (and economic reward) by separating themselves from mere crafts or trades. This process may be traced clearly with the aspiration of British portrait painters (headed by Sir Joshua Reynolds), in the eighteenth century, to acquire a social status akin to that of already established professionals, such as clerics and doctors. This may be understood, to a significant degree, as a process of gentrification. The values of the professional thereby lie as much in the etiquette and other social skills with which they deal with their clients, than with any distinctive form of skill or value. Professionalisation as gentrification seemingly says little about the nature of modern professionalism. However, if this process is also construed as one in which the goals and achievements of the profession come to be subject to radical reflection, then something significant about professional values emerges. On this account, the profession is distinguished from craft or trade on the grounds that the goals of the profession, and the effectiveness of any attempt to realise them, are not transparent to the client. While a lay person will typically have the competence necessary to judge whether or not a craft worker has achieved their goal, that person will not necessarily be able to recognise the values that determine the success of a medical operation. It will be concluded that the values of a profession are articulated intrinsically to the profession, in terms of the contested understanding that the professionals themselves have of the meaning of the profession and the narratives within which its history is to be told.

  1. Patent Races and Market Value

    DEFF Research Database (Denmark)

    Czarnitzki, Dirk; Hussinger, Katrin; Leten, Bart

    Patent races are models of strategic interactions between firms competing to develop an invention. The winning firm secures a patent, protecting the invention from imitation. This paper tests the assumption made about the reward structure in patent races, both in discrete and complex industries. We...... identify patent race winners using detailed information from the patent examination reports at the European Patent Office (EPO). Estimates of a market value equation featuring large, R&D-intensive U.S., European and Japanese firms, show that if firms win patent races, their market value increases...... significantly. We further show that the gain in market value is significantly larger for patent race winners in discrete industries than for firms in complex industries....

  2. Labour in Global Value Chains

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Nadvi, Khalid; Chan, Anita

    2012-01-01

    production contexts that influence work conditions. In doing so, it argues that current debates on the role of labour in global value chains have to go beyond a narrow focus on labour standards and corporate social responsibility compliance and engage with economic, technological and social upgrading......A critical challenge facing developing country producers is to meet international labour standards and codes of conduct in order to engage in global value chains. Evidence of gains for workers from compliance with such standards and codes remains limited and patchy. This article focuses...... on the global football industry, a sector dominated by leading global brands that manage dispersed global value chains. It assesses the working conditions for football stitchers engaged in different forms of work organization, factories, stitching centres and home-based settings in Pakistan, India and China...

  3. System for memorizing maximum values

    Science.gov (United States)

    Bozeman, Richard J., Jr.

    1992-08-01

    The invention discloses a system capable of memorizing maximum sensed values. The system includes conditioning circuitry which receives the analog output signal from a sensor transducer. The conditioning circuitry rectifies and filters the analog signal and provides an input signal to a digital driver, which may be either linear or logarithmic. The driver converts the analog signal to discrete digital values, which in turn triggers an output signal on one of a plurality of driver output lines n. The particular output lines selected is dependent on the converted digital value. A microfuse memory device connects across the driver output lines, with n segments. Each segment is associated with one driver output line, and includes a microfuse that is blown when a signal appears on the associated driver output line.

  4. Complex-Valued Neural Networks

    CERN Document Server

    Hirose, Akira

    2012-01-01

    This book is the second enlarged and revised edition of the first successful monograph on complex-valued neural networks (CVNNs) published in 2006, which lends itself to graduate and undergraduate courses in electrical engineering, informatics, control engineering, mechanics, robotics, bioengineering, and other relevant fields. In the second edition the recent trends in CVNNs research are included, resulting in e.g. almost a doubled number of references. The parametron invented in 1954 is also referred to with discussion on analogy and disparity. Also various additional arguments on the advantages of the complex-valued neural networks enhancing the difference to real-valued neural networks are given in various sections. The book is useful for those beginning their studies, for instance, in adaptive signal processing for highly functional sensing and imaging, control in unknown and changing environment, robotics inspired by human neural systems, and brain-like information processing, as well as interdisciplina...

  5. The Value Question in Metaphysics

    Science.gov (United States)

    Kahane, Guy

    2012-01-01

    Much seems to be at stake in metaphysical questions about, for example, God, free will or morality. One thing that could be at stake is the value of the universe we inhabit—how good or bad it is. We can think of competing philosophical positions as describing possibilities, ways the world might turn out to be, and to which value can be assigned. When, for example, people hope that God exists, or fear that we do not possess free will, they express attitudes towards these possibilities, attitudes that presuppose answers to questions about their comparative value. My aim in this paper is to distinguish these evaluative questions from related questions with which they can be confused, to identify structural constraints on their proper pursuit, and to address objections to their very coherence. Answers to such evaluative questions offer one measure of the importance of philosophical disputes. PMID:23024399

  6. Value of credit bureau reports

    Directory of Open Access Journals (Sweden)

    Brković Milan

    2017-01-01

    Full Text Available An efficient system of credit information sharing contributes to solving the problem of information asymmetry on the credit and financial markets in general. The consequences of the global economic and financial crisis revealed an increasing demand for reliable information and data which could close the existing gap in their insufficiency, misuse or inadequate analytical value for the economic and financial policy makers. In that sense, more attention is directed to the usefulness of credit information sharing and the practical value of information and data contained in credit bureau reports for the purposes of achieving the overall economic policy goals. The fulfillment of that role depends mostly on the credit information sharing system and its characteristics, participants, and procedures. A credit bureau report in the best possible manner reflects all advantages and disadvantages of the established credit information exchange system in terms of its analytical value for the purposes of efficient macroeconomic and macrofinancial policies.

  7. Value Co-creation Behaviour

    DEFF Research Database (Denmark)

    Laud, Gaurangi; Karpen, Ingo Oswald

    2017-01-01

    Purpose:The purpose of this paper is to identify antecedents and consequences ofcustomers’ value co-creation behaviour (VCB). VCB as a means to facilitatevalue realisation processes is gaining importance in service research andpractice. Encouraging such enactments can be challenging, but can also...... offercompetitive advantages. Design/methodology/approach:We empirically investigate a conceptual model by converging threecontemporary concepts of co-creation research – embeddedness, VCB and value-in-context– and examining the interdependencies between them. Data were collected in anonline forum of a leading......, the studyhighlights the significance of the nature of customer’s social constellationsto develop contexts where value outcomes are actualised. Understanding thefactors that shape VCB offers insights for firms to recognise how and wherevalue propositions can be deployed that drives on-going co-creation processes...

  8. The Value Question in Metaphysics.

    Science.gov (United States)

    Kahane, Guy

    2012-07-01

    Much seems to be at stake in metaphysical questions about, for example, God, free will or morality. One thing that could be at stake is the value of the universe we inhabit-how good or bad it is. We can think of competing philosophical positions as describing possibilities, ways the world might turn out to be, and to which value can be assigned. When, for example, people hope that God exists, or fear that we do not possess free will, they express attitudes towards these possibilities, attitudes that presuppose answers to questions about their comparative value. My aim in this paper is to distinguish these evaluative questions from related questions with which they can be confused, to identify structural constraints on their proper pursuit, and to address objections to their very coherence. Answers to such evaluative questions offer one measure of the importance of philosophical disputes.

  9. Deprival value: information utility analysis

    Directory of Open Access Journals (Sweden)

    Marco Antonio Pereira

    Full Text Available ABSTRACT This article contributes to the perception that the users’ learning process plays a key role in order to apply an accounting concept and this involves a presentation that fits its informative potential, free of previous accounting fixations. Deprival value is a useful measure for managerial and corporate purposes, it may be applied to the current Conceptual Framework of the International Accounting Standards Board (IASB. This study analyzes its utility, taking into account cognitive aspects. Also known as value to the business, deprival value is a measurement system that followed a path where it was misunderstood, confused with another one, it faced resistance to be implemented and fell into disuse; everything that a standardized measurement method tries to avoid. In contrast, deprival value has found support in the academy and in specific applications, such as those related to the public service regulation. The accounting area has been impacted by sophistication of the measurement methods that increasingly require the ability to analyze accounting facts on an economic basis, at the risk of loss of their information content. This development becomes possible only when the potential of a measurement system is known and it is feasible to be achieved. This study consists in a theoretical essay based on literature review to discuss its origin, presentation, and application. Considering the concept’s cognitive difficulties, deprival value was analyzed, as well as its corresponding heteronym, value to the business, in order to explain some of these changes. The concept’s utility was also explored through cross-analysis with impairment and the scheme developed was applied to actual economic situations faced by a company listed on stock exchange.

  10. Realizing "value-added" metrology

    Science.gov (United States)

    Bunday, Benjamin; Lipscomb, Pete; Allgair, John; Patel, Dilip; Caldwell, Mark; Solecky, Eric; Archie, Chas; Morningstar, Jennifer; Rice, Bryan J.; Singh, Bhanwar; Cain, Jason; Emami, Iraj; Banke, Bill, Jr.; Herrera, Alfredo; Ukraintsev, Vladamir; Schlessinger, Jerry; Ritchison, Jeff

    2007-03-01

    The conventional premise that metrology is a "non-value-added necessary evil" is a misleading and dangerous assertion, which must be viewed as obsolete thinking. Many metrology applications are key enablers to traditionally labeled "value-added" processing steps in lithography and etch, such that they can be considered integral parts of the processes. Various key trends in modern, state-of-the-art processing such as optical proximity correction (OPC), design for manufacturability (DFM), and advanced process control (APC) are based, at their hearts, on the assumption of fine-tuned metrology, in terms of uncertainty and accuracy. These trends are vehicles where metrology thus has large opportunities to create value through the engineering of tight and targetable process distributions. Such distributions make possible predictability in speed-sorts and in other parameters, which results in high-end product. Additionally, significant reliance has also been placed on defect metrology to predict, improve, and reduce yield variability. The necessary quality metrology is strongly influenced by not only the choice of equipment, but also the quality application of these tools in a production environment. The ultimate value added by metrology is a result of quality tools run by a quality metrology team using quality practices. This paper will explore the relationships among present and future trends and challenges in metrology, including equipment, key applications, and metrology deployment in the manufacturing flow. Of key importance are metrology personnel, with their expertise, practices, and metrics in achieving and maintaining the required level of metrology performance, including where precision, matching, and accuracy fit into these considerations. The value of metrology will be demonstrated to have shifted to "key enabler of large revenues," debunking the out-of-date premise that metrology is "non-value-added." Examples used will be from critical dimension (CD

  11. Dietary reference values for thiamin

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived dietary reference values (DRVs) for thiamin (vitamin B1). The Panel considers that data from depletion–repletion studies in adults on the amount of dietary thiamin intake...... were measured. Results from other depletion–repletion studies are in agreement with this value. The Panel agrees on the coefficient of variation of 20% used by the SCF to cover uncertainties related to distribution of thiamin requirements in the general population, and endorses the population reference...

  12. Environmental Protection and Value Creation

    Directory of Open Access Journals (Sweden)

    Faizah Darus

    2016-01-01

    Full Text Available The managers of corporations can play a significant role to protect the natural environment. This study aims to examine the environmental disclosure of 200Shariah compliant companies for 2013 and the subsequent effect of such disclosure for the organizations. The results of content analyses of the annual reports revealed that managers from the Plantation industry disclosed more environmental information. The regression analysis revealed a significant relationship between environmental information provided and the subsequent value created for the organizations. The findings of the study can help managers to position better their environmental strategy to enhance the overall value of their organizations.

  13. Integer-valued trawl processes

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole E.; Lunde, Asger; Shephard, Neil

    2014-01-01

    the probabilistic properties of such processes in detail and, in addition, study volatility modulation and multivariate extensions within the new modelling framework. Moreover, we describe how the parameters of a trawl process can be estimated and obtain promising estimation results in our simulation study. Finally......This paper introduces a new continuous-time framework for modelling serially correlated count and integer-valued data. The key component in our new model is the class of integer-valued trawl processes, which are serially correlated, stationary, infinitely divisible processes. We analyse...

  14. Value metrics for better lighting

    CERN Document Server

    Rea, Mark S

    2012-01-01

    We often do not fully understand what lighting can do for us. We know that we need lighting, but often that is as far as the thinking goes. We do a really good job, however, of conceptualizing the costs of those lighting systems because we can readily measure those costs. Reducing costs will certainly increase the value ratio for lighting if the benefits of the lighting system are held constant. Without a clear purpose for the lighting system, and no clear idea of benefits, there is little else that can be used in the value engineering process. This book is dedicated to the notion that our s

  15. Value Creation in Knowledge Networks

    DEFF Research Database (Denmark)

    Hansen, Magnus Rotvit Perlt; Pries-Heje, Jan

    2017-01-01

    Knowledge networks enable businesses to enhance their levels of innovation and market competitiveness. In this paper, we propose five principles for designing IT tools that can support the facilitation and improvement of knowledge networks. We also introduce a new value proposition that constitutes...... a nascent design theory in the domain of knowledge network improvement. The design principles are derived from an iterative process applied in three different case settings. In each case, we apply and evaluate the network nexus tool to determine whether the knowledge network provides value to its...

  16. Thoughts on Earned Value Assessments

    Science.gov (United States)

    Pido, Kelle

    2009-01-01

    This slide presentation reviews the concepts of Earned Value reporting and Earned Value Metrics (EVM) and the implementation for the Constellation Program. EVM is used to manage both the contract and civil service workforce, and used as a measure of contractor costs and performance. The Program EVM is not as useful for Level of Effort tasking, for either contractor, or civil service employees. Some issues and concerns in reference to EVM and the process for the use of EVM for Mission assurance are reviewed,

  17. Determinants of the company value

    Directory of Open Access Journals (Sweden)

    Kamila Růžičková

    2011-01-01

    Full Text Available Today, there are many conceptions involving creation of the company value, as it is the main objective for the owners. However, there are still many companies interested primarily in the different company’s objectives and enhance its competitive position differently. The aim of the paper is to present and analyze the viewpoints of Czech and foreign specialists on the issue of company value creation. The paper provides the determination of factors positively influencing the company value, the description of their characteristics, and on the basis of a detailed academic discussion proposes conclusions. Attention is paid especially to the value drivers which are not recorded in the financial documents.The introduction of the paper gives a brief overview of the topic. The paper is divided into three main parts. The first part introduces the effective cost management. It clarifies the concept of the managerial accounting and explains its contribution to the creation of the company value. The second part deals with the external relationships of the company. It focuses on the buyer-supplier relationships and offers the detailed perspective on the specific issue of the agricultural companies and their competitiveness in relation to the land leases. The third part concentrates on the internal company environment, namely on the human capital potential and its effects on the value of the company. In the concluding part, the findings are summarized. Based on the results, the figure describing the determinants and generators of the company value is formed. This figure can be considered a systematic procedure how to create a company value.All findings are supported with the literature review e.g. Armstrong (2007, Fibírová and Šoljaková (2005, Marinič (2008, Petřík (2007 and Porter (2004. Within the paper elaboration, the analysis and synthesis as scientific methods were used for explanation of the experts’ points of view and then summed up as the

  18. The Competing Values of Hackers

    DEFF Research Database (Denmark)

    Mûller, Sune Dueholm; Ulrich, Frank

    2015-01-01

    In this paper we describe the hacker culture by analyzing 25 years of communication on one of the oldest and most renowned hacker websites. For this purpose, we utilize a previously documented text analysis technique [14] which provides an efficient and effective method of producing a quick...... overview of values underlying any written text. The technique allows for the creation of culture profiles of texts based on the competing values framework [2]. The article contributes to understanding an important but overlooked hotbed of creativity—the hacker community. It provides examples of how hackers...

  19. CASSAVA BREEDING I: THE VALUE OF BREEDING VALUE

    Directory of Open Access Journals (Sweden)

    Hernán Ceballos

    2016-08-01

    Full Text Available Breeding cassava relies on several selection stages (single row trial-SRT; preliminary; advanced; and uniform yield trials - UYT. This study uses data from 14 years of evaluations. From more than 20,000 genotypes initially evaluated only 114 reached the last stage. The objective was to assess how the data at SRT could be used to predict the probabilities of genotypes reaching the UYT. Phenotypic data from each genotype at SRT was integrated into the selection index (SIN used by the cassava breeding program. Average SIN from all the progenies derived from each progenitor was then obtained. Average SIN is an approximation of the breeding value of each progenitor. Data clearly suggested that some genotypes were better progenitors than others (e.g. high number of their progenies reaching the UYT, suggesting important variation in breeding values of progenitors. However, regression of average SIN of each parental genotype on the number of their respective progenies reaching UYT resulted in a negligible coefficient of determination (r2 = 0.05. Breeding value (e.g. average SIN at SRT was not efficient predicting which genotypes were more likely to reach the UYT stage. Number of families and progenies derived from a given progenitor were more efficient predicting the probabilities of the progeny from a given parent reaching the UYT stage. Large within-family genetic variation tends to mask the true breeding value of each progenitor. The use of partially inbred progenitors (e.g. S1 or S2 genotypes would reduce the within-family genetic variation thus making the assessment of breeding value more accurate. Moreover, partial inbreeding of progenitors can improve the breeding value of the original (S0 parental material and sharply accelerate genetic gains. For instance, homozygous S1 genotypes for the dominant resistance to cassava mosaic disease could be generated and selected. All gametes from these selected S1 genotypes would carry the desirable allele

  20. The antioxidant activity test by using DPPH method from the white tea using different solvents

    Science.gov (United States)

    Darmajana, Doddy A.; Hadiansyah, Firman; Desnilasari, Dewi

    2017-11-01

    The solvents used in this study are: aquades, ethanol and glacial acetic acid. The raw material as the source of antioxidants is white tea. Pure Quercetin is used as a comparing antioxidant. The treatment design was the solvent type for extraction, while the antioxidant activity was tested using DPPH method, with IC50 as the reference of antioxidant activity value. The results of antioxidant activity tests with three different solvent types are IC50 of 22,499 µg/mL for aquades, IC50 of 13,317 µg/mL for Ethanol and IC50 of 60,555 µg/mL for Glacial Acetic Acid. As a control of the standard antioxidant activity value of Quercetin is 4,313 µg/mL.

  1. The Epistemic Value of Curiosity

    Science.gov (United States)

    Schmitt, Frederick F.; Lahroodi, Reza

    2008-01-01

    In this essay, Frederick Schmitt and Reza Lahroodi explore the value of curiosity for inquiry and knowledge. They defend an appetitive account of curiosity, viewing curiosity as a motivationally original desire to know that arises from having one's attention drawn to the object and that in turn sustains one's attention to it. Distinguishing…

  2. Tree value conversion standards revisited

    Science.gov (United States)

    Paul S. DeBald; Martin E. Dale; Martin E. Dale

    1991-01-01

    Updated tree value conversion standards (TVCS) are presented for 12 important hardwood species of the oak-hickory forest. These updated standards-developed for each species by butt-log grade, merchantable height, and diameter at breast height-reflect the changes in lumber prices and in conversion costs which have occurred since 1976 when the original TVCS were...

  3. Enhancing value of information analyses

    NARCIS (Netherlands)

    Janssen, Mart P.; Koffijberg, Hendrik

    Objective: The aim of this study was to demonstrate that it is feasible and recommendable to present value of information (VOI) outcomes in terms of underlying costs and effects in addition to costs alone. Methods: The benefits of collecting additional information on health economic outcomes before

  4. Richard Peters and Valuing Authenticity

    Science.gov (United States)

    Degenhardt, M. A. B.

    2009-01-01

    Richard Peters has been praised for the authenticity of his philosophy, and inquiry into aspects of the development of his philosophy reveals a profound authenticity. Yet authenticity is something he seems not to favour. The apparent paradox is resolved by observing historical changes in the understanding of authenticity as an important value.…

  5. Forecasting the Value of Training

    Science.gov (United States)

    Basarab, Dave

    2011-01-01

    The Predictive Evaluation (PE) model is a training and evaluation approach with the element of prediction. PE allows trainers and business leaders to predict the results, value, intention, adoption, and impact of training, allowing them to make smarter, more strategic training and evaluation investments. PE is invaluable for companies that…

  6. Democratic values, emotions and emotivism

    Directory of Open Access Journals (Sweden)

    Vranić Bojan

    2016-01-01

    Full Text Available The aim of this paper is to explore the relation between democratic values and emotions. The author argues that democratic values and emotional judgments are inter-reducible: political agents use emotional judgments to reflexively evaluate normative paradigms of political life. In the first part of the paper, the author describes the state of emotions in contemporary political philosophy and identifies Charles Stevenson’s ethical conception of emotivism as the first comprehensive attempt to neutrally conceptualize emotions in moral and political thinking. The second part of the paper explores the shortcomings of emotivism and finds an adequate alternative in Martha Nussbaum’s concept of emotional judgment as the one that contains beliefs and values about social objects. In the final part of the paper, the author identifies that moral and political disagreements emerge in democracies from ranking of the importance of political objects. The evaluation criteria for this type of ranking is derived from democratic values which are reducible to agents’ emotional judgments. [Projekat Ministarstva nauke Republike Srbije, br. 179076

  7. The Value of Environmental Ethics.

    Science.gov (United States)

    Hargrove, Eugene C.

    1987-01-01

    Discusses some of the views of environmentalists toward the study of environmental ethics. Addresses the problem that environmental ethics literature is difficult to read and argues that certain opinions about the value of the study of environmental ethics are rooted in misconceptions. (TW)

  8. Working with values in coaching

    DEFF Research Database (Denmark)

    Stelter, Reinhard

    2016-01-01

    : - Existential coaching - Protreptic coaching as a philosophically inspired coaching approach - Third-generation coaching as a narrative-collaborative practice The overall objective of this chapter is to present and discuss the state of knowledge about values as a central aspect of the coaching process...

  9. Sexual Values of 783 Undergraduates

    Science.gov (United States)

    Richey, Emily; Knox, David; Zusman, Marty

    2009-01-01

    The sexual values of absolutism (abstinence until marriage), relativism (sexual decisions made in reference to the nature of the relationship), and hedonism ("if it feels good, do it") were assessed in a convenience sample of 783 undergraduate students at a large southeastern university. Results revealed that relativism (62.1%) was the predominate…

  10. Dietary reference values for riboflavin

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2017-01-01

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives dietary reference values (DRVs) for riboflavin. The Panel considers that the inflection point in the urinary riboflavin excretion curve in relation to riboflavin intake...

  11. Dietary reference values for potassium

    DEFF Research Database (Denmark)

    Sjödin, Anders Mikael

    2016-01-01

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives dietary reference values (DRVs) for potassium. The Panel decides to set DRVs on the basis of the relationships between potassium intake and blood pressure and stroke...

  12. Integer-valued time series

    NARCIS (Netherlands)

    van den Akker, R.

    2007-01-01

    This thesis adresses statistical problems in econometrics. The first part contributes statistical methodology for nonnegative integer-valued time series. The second part of this thesis discusses semiparametric estimation in copula models and develops semiparametric lower bounds for a large class of

  13. Backtesting Value-at-Risk

    DEFF Research Database (Denmark)

    Pajhede, Thor

    2017-01-01

    Testing the validity of value-at-risk (VaR) forecasts, or backtesting, is an integral part of modern market risk management and regulation. This is often done by applying independence and coverage tests developed by Christoffersen (International Economic Review, 1998; 39(4), 841–862) to so...

  14. HISTORICAL COST VERSUS FAIR VALUE

    Directory of Open Access Journals (Sweden)

    Cozma Ighian Diana

    2009-05-01

    Full Text Available The current process of accounting globalization is based mainly on the concept of just value. This concept has been the source of vivid debates with regards to its meaning in contemporary accountancy, both in theory and in practice. The increased importan

  15. Adding Value: Online Student Engagement

    Science.gov (United States)

    Everett, Donna R.

    2015-01-01

    This paper seeks to add to the emerging literature related to online student engagement with additional suggestions for instructional strategies. Student engagement is one of the tenets of effective online instruction; as such, particular attention to how it adds value to student learning is crucial and worth the time and effort to enhance…

  16. Naturalness as an educational value

    DEFF Research Database (Denmark)

    Frølund, Sune

    2016-01-01

    Existentialism and postmodernism have both abandoned the idea of a human nature. Also, the idea of naturalness as a value for education has been targeted as a blind for conservative ideology. There are, however, good reasons to re-establish a sound concept of human naturalness. First of all...

  17. What Works in Values Education

    Science.gov (United States)

    Berkowitz, Marvin W.

    2011-01-01

    Values education (alternatively, moral education, character education) is the attempt, within schools, to craft pedagogies and supportive structures to foster the development of positive, ethical, pro-social inclinations and competencies in youth, including around strengthening their academic focus and achievement. Recent research has uncovered…

  18. Semiproportional values for TU games

    NARCIS (Netherlands)

    Khmelnitskaya, Anna Borisovna; Driessen, Theo

    2003-01-01

    The goal of the paper is to introduce a family of values for transferable utility cooperative games that are proportional for two-person games and as well satisfying some combinatorial structure composed by contributions of complementary coalitions or, to less extent, marginal contributions by

  19. Semiproportional values for TU games

    NARCIS (Netherlands)

    Khmelnitskaya, Anna Borisovna; Driessen, Theo

    2002-01-01

    The goal of the paper is to introduce a family of values for transferable utility cooperative games that are proportional for two-person games and as well satisfying some combinatorial structure composed by contributions of complementary coalitions or, to less extent, marginal contributions by

  20. The Geometric Mean Value Theorem

    Science.gov (United States)

    de Camargo, André Pierro

    2018-01-01

    In a previous article published in the "American Mathematical Monthly," Tucker ("Amer Math Monthly." 1997; 104(3): 231-240) made severe criticism on the Mean Value Theorem and, unfortunately, the majority of calculus textbooks also do not help to improve its reputation. The standard argument for proving it seems to be applying…

  1. Market value of wind power

    NARCIS (Netherlands)

    Haan, de J.E.S.; Shoeb, M.A.; Lopes Ferreira, H.M.; Kling, W.L.

    2013-01-01

    Variability and predictability constraints of wind hinder the cost-efficient integration of wind power generation into power markets. Within the framework of EIT KIC INNOENERGY Offwindtech project, a ‘Market Value’ tool is developed. Here, the market value of wind power generation can be assessed

  2. Economic demand and essential value.

    Science.gov (United States)

    Hursh, Steven R; Silberberg, Alan

    2008-01-01

    The strength of a rat's eating reflex correlates with hunger level when strength is measured by the response frequency that precedes eating (B. F. Skinner, 1932a, 1932b). On the basis of this finding, Skinner argued response frequency could index reflex strength. Subsequent work documented difficulties with this notion because responding was affected not only by the strengthening properties of the reinforcer but also by the rate-shaping effects of the schedule. This article obviates this problem by measuring strength via methods from behavioral economics. This approach uses demand curves to map how reinforcer consumption changes with changes in the "price" different ratio schedules impose. An exponential equation is used to model these demand curves. The value of this exponential's rate constant is used to scale the strength or essential value of a reinforcer, independent of the scalar dimensions of the reinforcer. Essential value determines the consumption level to be expected at particular prices and the response level that will occur to support that consumption. This approach permits comparing reinforcers that differ in kind, contributing toward the goal of scaling reinforcer value. (c) 2008 APA, all rights reserved

  3. Value and Pricing of MOOCs

    Science.gov (United States)

    Baker, Rose M.; Passmore, David L.

    2016-01-01

    Reviewed in this article is the potential for Massive Open Online Courses (MOOCs) to transform higher education delivery, accessibility, and costs. Next, five major value propositions for MOOCs are considered (headhunting, certification, face-to-face learning, personalized learning, integration with services external to the MOOC, marketing). Then,…

  4. Asian Values, Education and Development.

    Science.gov (United States)

    Cummings, William K.

    1996-01-01

    Maintains that many issues and questions concerning the relationship between Asian values and education have never been addressed in a comprehensive and systematic manner. Outlines four broad areas of inquiry: origins of culture, savings/investment effect, quality effect, and stability effect. Includes statistical information on education and…

  5. The Facilities Management Value Map

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2008-01-01

    the ways FM can create added value. The method has found inspiration in the strategic mapping from balanced score card methodology. The result is identification of the main resources, processes and products/deliveries in FM, the principal ways FM creates impacts on the core business as well as society...

  6. Plausible values in statistical inference

    NARCIS (Netherlands)

    Marsman, M.

    2014-01-01

    In Chapter 2 it is shown that the marginal distribution of plausible values is a consistent estimator of the true latent variable distribution, and, furthermore, that convergence is monotone in an embedding in which the number of items tends to infinity. This result is used to clarify some of the

  7. Moral Rudders and Superintendent Values

    Science.gov (United States)

    Kidder, Rushworth M.

    2008-01-01

    The core challenge is this--a difficult ethical decision, where values are in play and both sides have powerful moral arguments in their favor. One case presented in this article outlines a dilemma faced by one teacher who became a superintendent herself. The case exploded dramatically in a midsize metropolitan school district, where a principal…

  8. The Value of the Arts

    Science.gov (United States)

    Tubbs, Nigel

    2013-01-01

    The value of the arts is often measured in terms of human creativity against instrumental rationality, while art for art's sake defends against a utility of art. Such critiques of the technical and formulaic are themselves formulaic, repeating the dualism of the head and the heart. How should we account for this formula? We should do so by…

  9. More value to defining quality

    NARCIS (Netherlands)

    prof.dr.ing T.W. Hardjono; Mike Pupius; PhD Everard van Kemenade

    2008-01-01

    There are lots of definitions of quality, and also of quality in education. Garvin (1984)discerns five approaches: the transcendental approach, the product-oriented approach, the customeroriented approach, the manufacturing-oriented approach and the value-for-money approach. Harvey and Green (1993)

  10. HOW APPRAISERS DEVELOP FAIR VALUE

    Directory of Open Access Journals (Sweden)

    MIROSLAV ŠKODA

    2012-01-01

    Full Text Available Management is responsible for its own financial decisions. If we take into account, that fair value concept was shown in financial crisis as something that does not work anymore in this way; there is a big need to develop it for the future. Non-professional readers of financial statements believe, however, that company financials are the work of the public accounting firm that had signed the audit certificate. The main reason for bringing this point up is that when companies disclose Fair Value (FV information in their financial statements, they are taking responsibility for the values disclosed. Management may often be encouraged to utilize the services of an outside professional, but at the end of the day, the outside appraiser is a hired gun. Although the appraiser has to take responsibility for his own work, hiring the appraiser does not absolve management of its ultimate responsibility. The obverse of this is also true. Management does not have to hire the appraiser to develop any fair value disclosures made in the financial statements. Developing FV information is not recommended as a do-it yourself undertaking, there is nothing in Generally Accepted Accounting Principles (GAAP or Securities Exchange Commission (SEC regulations, however, that requires an outside appraiser.

  11. Graduates: Perceptions of MBA Value

    Science.gov (United States)

    Bledsoe, Maynard T.; Oatsvall, Rebecca

    2009-01-01

    MBA worth--who decides? Much of the current assessment comes from market driven and/or institutional perspectives. This research examines responses from Meredith College MBA graduates to determine their perceptions of the worth and value of their MBA experience.

  12. Value based pricing: the least valued pricing strategy

    OpenAIRE

    Hoenen, Bob

    2017-01-01

    Pricing has been one of the least researched topics in marketing, although within these pricing strategies: cost-plus pricing is considered as the leading pricing strategy worldwide. Why should companies use such an unprofitable strategy, where fighting for a higher market share due to low prices is more a rule than exception? VBP is one of the most underestimated strategies by organizations. The definition of VBP is: 'value pricing applies to products that have the potential of being differe...

  13. Recreation value of a waterway and changes in this value

    International Nuclear Information System (INIS)

    Aittoniemi, P.

    1991-01-01

    The uniquely rich hydrological and archipelagic nature of Finland creates versatile opportunities for spending of leisure time. As various uses of waterways compete with each other, it is difficult to compare advantages and disadvantages of operations in view of various interests. This is why efforts have been made to develop methods to make the effect commensurable. Usability of shores is one important factor in the assessment of recreation use of waterways. When influence of water level changes in usability of shores is estimated, shore and bottom slope and quality, and uses and user numbers of the shores must be known. In several assessment methods, usability of shore is depicted by distance of the shifted shoreline (due to the changed water level) from the 'good' status. The studies on changes in the recreation value or usability of shores should be started by making efforts to classify and estimate various effects separately. If the value is wished to be given as one figure, the calculation basis applied, the weights and the used value functions must be stated clearly with the results. It is equally important to make a sensitivity analysis, i.e. to study effects of changes in uncertain input data on the results

  14. 2,4,6-Trichlorophenylhydrazine Schiff bases as DPPH radical and super oxide anion scavengers.

    Science.gov (United States)

    Khan, Khalid Mohammed; Shah, Zarbad; Ahmad, Viqar Uddin; Khan, Momin; Taha, Muhammad; Rahim, Fazal; Ali, Sajjad; Ambreen, Nida; Perveen, Shahnaz; Choudhary, M Iqbal; Voelter, Wolfgang

    2012-05-01

    Syntheses of thirty 2,4,6-trichlorophenylhydrazine Schiff bases 1-30 were carried out and evaluated for their in vitro DPPH radical and super oxide anion scavenging activities. Compounds 1-30 have shown a varying degree of DPPH radical scavenging activity and their IC50 values range between 4.05-369.30 µM. The compounds 17, 28, 18, 14, 8, 15, 12, 2, 29, and 7 exhibited IC50 values ranging between 4.05±0.06-24.42±0.86 µM which are superior to standard n-propylgallate (IC50=30.12±0.27 µM). Selected compounds have shown a varying degree of superoxide anion radical scavenger activity and their IC50 values range between 91.23-406.90 µM. The compounds 28, 8, 17, 15, and 14, showed IC50 values between 91.23±1.2-105.31±2.29 µM which are superior to standard n-propylgallate (IC50=106.34±1.6 µM).

  15. Handcraft: merchandise, value and fetish

    Directory of Open Access Journals (Sweden)

    Emanuelle Kelly Ribeiro da Silva

    2016-06-01

    Full Text Available The article aims to expose reflections on the handcraft as a symbolic differential for fashion products and design. The text presents reflections on the representations of craft production to the consumer market from the study of the categories: commodity fetish and value. Therefore, they were used with theoretical support the concepts erected by Karl Marx and empirical observations on the exploitation of handcraft by the current luxury market, for example. The methodological routes adopted for the construction of research guided in field research, specifically with participant observation, and literature review. The results point to the construction of interesting reflections on the exploitation of cultural goods and elements derived from popular culture as agregators value to drivers of consumption today.

  16. Commensalistic institutions and value conflicts

    DEFF Research Database (Denmark)

    Botterill, Linda Courtenay; Daugbjerg, Carsten

    2015-01-01

    their emergence as technical barriers to trade. The Agreement privileges free trade and scientific evidence, thus excluding many ethical considerations from the regulations that national governments can enact in relation to production methods in the agri-food chain. Autonomously from the SPS Agreement, a number...... of global private standard schemes have been developed that have incorporated values rejected by the SPS Agreement. This paper examines the relationship between the Agreement and the private standards and argues that this case highlights a gap in the institutional literature with respect to parallel...... institutions emerging autonomously from the primary institution to embody values excluded by the latter. We adopt the term commensalism for these previously undescribed relationships....

  17. Work values among Lebanese workers.

    Science.gov (United States)

    Sidani, Y M; Gardner, W L

    2000-10-01

    On the basis of a review of the existing literature, the authors tested 4 hypotheses to determine the applicability of work values in Arab societies to employees in Lebanese organizations. Only 1 hypothesis was supported: Organizational policies that ran counter to the worker's religious values had an adverse effect on job satisfaction. There was no support for the hypotheses (a) that workers' religiosity in inversely related to positive attitudes toward women's involvement at work, (b) that employee satisfaction is related to a mechanistic organizational design, or (c) that workers with an internal locus of control experience higher job satisfaction. The Lebanese workers, thus, did not appear to share some of the attributes claimed to exist in Arab societies.

  18. Weak values in collision theory

    Science.gov (United States)

    de Castro, Leonardo Andreta; Brasil, Carlos Alexandre; Napolitano, Reginaldo de Jesus

    2018-05-01

    Weak measurements have an increasing number of applications in contemporary quantum mechanics. They were originally described as a weak interaction that slightly entangled the translational degrees of freedom of a particle to its spin, yielding surprising results after post-selection. That description often ignores the kinetic energy of the particle and its movement in three dimensions. Here, we include these elements and re-obtain the weak values within the context of collision theory by two different approaches, and prove that the results are compatible with each other and with the results from the traditional approach. To provide a more complete description, we generalize weak values into weak tensors and use them to provide a more realistic description of the Stern-Gerlach apparatus.

  19. Food irradiation and consumer values

    International Nuclear Information System (INIS)

    Bruhn, C.M.; Schutz, H.G.; Sommer, R.

    1988-01-01

    A mail survey technique was used to determine if value hierarchy, locus of control, innovativeness, and demographic parameters could distinguish between subjects expressing different levels of concern and willingness to buy irradiated food. Concern toward irradiated food was lower than concern for other food safety issues, probably because many expressed uncertainty regarding irradiation. Those ranking the value “an ecologically balanced world” expressed the greatest irradiation concern. Factors which could predict high irradiation concern were being highly concerned about the use of chemical sprays on food, completing more formal education and being female; those believing that life was controlled by luck were less concerned. Irradiation concern was a principal factor determining willingness to buy irradiated foods. Innovative consumers were more likely to try irradiated foods than noninnovative. Implications for consumer education are presented

  20. Risk management and corporate value

    Directory of Open Access Journals (Sweden)

    Milan Cupic

    2015-12-01

    Full Text Available The paper presents a theoretical framework for assessing the impact of risk management on corporate value. As the relevant factors that determine this impact, the paper analyzes market imperfections and investors’ risk aversion. The results of the present research indicate that risk management contributes to an increase in corporate value if, under the influence of market imperfections, corporate risk exposure is concave. As an expression of market imperfections, the paper analyzes the costs of financial distress, agency costs, and taxation. The results of the research also indicate that the risk management policy should not aim to minimize, but rather optimize risk exposure, by taking into account the costs of risk management, investors’ risk aversion and the competitive advantage a corporation has on the relevant market.

  1. Nutritional value of irradiated food

    International Nuclear Information System (INIS)

    Diehl, J.F.; Hasselmann, C.; Kilcast, D.

    1991-01-01

    Statements made in 2 reports by the European Parliamentary Commission on the Environment, Public Health and Consumer Protection, chaired on both occasions by members of the German Green Party, that irradiated foods have no nutritional value are challenged. Attempts by the European Commission to regulate food irradiation in the European Community have been turned down by the European Parliament on the basis of these reports

  2. On the Fractional Mean Value

    OpenAIRE

    Hosseinabadi, Abdolali Neamaty; Nategh, Mehdi

    2014-01-01

    This work, dealt with the classical mean value theorem and took advantage of it in the fractional calculus. The concept of a fractional critical point is introduced. Some sufficient conditions for the existence of a critical point is studied and an illustrative example rele- vant to the concept of the time dilation effect is given. The present paper also includes, some connections between convexity (and monotonicity) with fractional derivative in the Riemann-Liouville sense.

  3. Measuring the value of intangibles

    DEFF Research Database (Denmark)

    Clausen, Saskia; Hirth, Stefan

    2016-01-01

    We propose a new earnings-based measure for the value of intangibles. To validate this measure, we compare it to commonly used proxies for intangible intensity, such as R&D expenses. While R&D expenses measure the investment in new intangibles, our new measure gauges the productivity of already e...... of our intangible-intensity measure in the context of capital structure. We find that more intangible-intensive firms have lower leverage. © 2016 Elsevier B.V....

  4. Culture and luxury value perception

    OpenAIRE

    Grange, Ségolène

    2015-01-01

    The aim of this study is to investigate how culture influences the way consumers perceive luxury. The model used in this paper combines previously developed frameworks concerning luxury value dimensions with the famous model of Hofstedes’ cultural dimensions. An online survey has been completed to collect data to compare responses of consumers from two different countries. Then an analysis of the data collected has been conducted in order to identify the cultural influence. ...

  5. CREATING VALUE WITHIN CONSUMPTION CULTURE

    Directory of Open Access Journals (Sweden)

    Daniel Adrian Gârdan

    2016-12-01

    Full Text Available The issue of culture consumption is a particular concern within the modern marketing theory. Culture can be seen as representing a body of knowledge, beliefs, values, attitudes, symbols etc, developed in a certain period of time by a group of individuals, items transmitted with the help of a social learning process to other generations within the group. Thus, the consumption of culture will identify itself with the consumption of any product, service or a combination of them, directly resulted as manifestation of culture, expressions of artistic creativity specific for a certain cultural space. The present paper proposes the analysis of the phenomenon referring to the culture consumption in terms of specific characteristics. The paper reviews the features specific to the modern consumer of culture, the relationship that exists between the individuals’ level of education and the culture consumption and value creation process or augmentation of the intrinsic value of an artistic product as a result of the contribution that the culture consumer can bring himself. The authors highlight the fact that within extremely complex processes which are defining the culture consumption, consumers can assume an active role, becoming on their turn co-participants in the cultural goods and services value creation and transmission. The modern consumer benefits more than ever from the advantages offered by the information technology, being called to respond to major challenges of the postmodernism paradigm in terms of culture consumption. Globalization and other social economic and politic phenomena have profoundly changed the reports between individual and culture, between self and other members of the society, causing synthesis and essential transformations of culture consumption, of culture consumers typologies, and not least of the very forms of artistic expression related to cultural goods and services.

  6. Irradiated food - no nutritional value?

    International Nuclear Information System (INIS)

    Diehl, J.F.; Hasselmann, C.

    1991-01-01

    Attempts by the European Commission to regulate food irradiation in the European Community by a directive have been repeatedly turned down by the European Parliament. The basis of information for the Parliamentarians was a Committee Report, which stated that irradiated foods had no nutritional value. This conclusion is compared with the richly available results of experimental studies. The authors conclude that the European Parliament has been completely misinformed. (orig.) [de

  7. Value and money in Marx

    Directory of Open Access Journals (Sweden)

    Fahd Boundi Chraki

    2018-04-01

    Full Text Available The aim of this paper is to examine the link between Marx's monetary theory and its explanation of value, production and circulation. For this, it presents the basic theoretical elements that allow a critique of the quantitative theory, the Chartalist conception of the genesis of money and the post-Keynesian theory of endogenous money. Then, from a Marxist perspective, it analyzes the controversial relationship between the monetization of public debt and the increase in the general level of prices.

  8. Telecommunication Value Network in Malaysia

    OpenAIRE

    Ong, Li Chien

    2009-01-01

    Business network is believed to offer a superior way of managing the challenges related to the uncertainty and complexity of the contemporary business environment in Malaysia telecommunication industry. This study strives to analyze the value business network in Malaysia telecommunication industry with emphasize on the market leader, Maxis Communication Bhd in its mobile content services. The business network represents the form of organization where the focal company focuses on certain key a...

  9. Value of Flexibility - Phase 1

    Science.gov (United States)

    2010-09-25

    010-1 9/25/10 UNCLASSIFIED 99  ― Nike shoes provide flexibility to the customer in terms of color choice, customized emblems (such as college...opportunity, he constructs a synthetic portfolio of a brand -new factory in a developing country, such as China, and bonds. Maybe the monetary values of both...1990s the DoD developed a new guidance kit using a combination of Inertial Navigation (INS) and the satellite based Global Positioning System (GPS

  10. Deprival value: information utility analysis

    OpenAIRE

    Pereira, Marco Antonio; Pinto, Alexandre Evaristo; Barbosa Neto, João Estevão; Martins, Eliseu

    2018-01-01

    ABSTRACT This article contributes to the perception that the users’ learning process plays a key role in order to apply an accounting concept and this involves a presentation that fits its informative potential, free of previous accounting fixations. Deprival value is a useful measure for managerial and corporate purposes, it may be applied to the current Conceptual Framework of the International Accounting Standards Board (IASB). This study analyzes its utility, taking into account cognitive...

  11. Climate change and shareholder value

    International Nuclear Information System (INIS)

    2006-01-01

    During 2005, the Carbon Trust worked with Cairneagle Associates to develop a methodology for analysing shareholder value at risk from climate change. The model developed offers a robust, replicable, top-down approach to analysing such value at risk. In addition to a company's own energy linked ('direct' and electricity linked 'indirect') carbon emissions, it looks further along the value chain and considers broader potential risk. In calculating the financial impact, the analysis quantifies the potential impact on profits, using the shape of the business in 2004, but applying a potential 2013 emissions regulatory regime. 2013 was chosen as the first year after the end of the 2008-2012 Kyoto compliance period (which also equates to Phase Two in the EU Emissions Trading Scheme). A major uncertainty is to what extent countries not currently regulated by the Kyoto Protocol (particularly the USA, India and China) will be brought into committed emission reduction targets from 2013. 2013 therefore represents the earliest year under this uncertain, but likely tougher, regulatory regime. However, although this report focuses on 2013, it needs to be recognised that, for many sectors, financial impacts will be seen significantly before this time. Ten 'case study companies' have been studied, from a range of sectors. In some cases, the 'case study company' analysed is strictly linked to a single company within that sector. In others, just a single corporate division has been reviewed, and in others yet again, characteristics from several companies have been combined to produce a more representative example. In order to enable analysis on a strictly like-for-like basis, the research has been based entirely upon public sources of information. This analysis illustrates what a determined shareholder (or other onlooker) could derive about value at risk from climate change, based upon what companies disclose today. A summary of the analysis for each sector case study is given, with

  12. Shapley's value for fuzzy games

    Directory of Open Access Journals (Sweden)

    Raúl Alvarado Sibaja

    2009-02-01

    Full Text Available This is the continuation of a previous article titled "Fuzzy Games", where I defined a new type of games based on the Multilinear extensions f, of characteristic functions and most of standard theorems for cooperative games also hold for this new type of games: The fuzzy games. Now we give some other properties and the extension of the definition of Shapley¨s Value for Fuzzy Games Keywords: game theory, fuzzy sets, multiattribute decisions.

  13. Historical Medical Value of Donguibogam

    Directory of Open Access Journals (Sweden)

    Bong-Keun Song

    2016-03-01

    Full Text Available Oriental medicine, since its origin in China, has had a long history extending over 2000 years. Today, it comprises several types of medicine predominately practiced in East Asia, including traditional Chinese, traditional Korean, and Kampo medicine. The distinctive medical system of traditional Korean medicine was established shortly after the publication of Donguibogam by Dr. Heo Jun in 1613. Donguibogam is highly acclaimed across East Asia; in 2009, in light of its historical medical value, the United Nations Educational, Scientific, and Cultural Organization registered the book on its cultural heritage list. Here, we review the historical medical value of Donguibogam. The findings confirm that Donguibogam developed a unique and independent form of traditional Korean medicine and innovatively reformed the disease classification system. Moreover, Donguibogam emphasized the importance of disease prevention and medical pragmatism. This book also accelerated the development of folk medicine. Owing to its historical medical value, Donguibogam is now considered the 'bible' of Oriental medicine. Its wide acceptance has contributed to the expansion of Korean medicine utilization among the general public. Donguibogam has also played an important role in the establishment of traditional Korean medicine as a universally valid and original form of medicine, independent of traditional Chinese medicine.

  14. Regional Branding: Building Brand Value

    Directory of Open Access Journals (Sweden)

    Klára Margarisová

    2016-01-01

    Full Text Available Regional branding is one of several ways to promote rural regions and support development of socially, culturally and environmentally oriented economies in areas that are interesting due to their natural and cultural heritage. The article attempts to review the conceptual and theoretical underpinnings of branding as conveyed by leading authors in the marketing field. The aim of this paper is to define brand as a broad complex of variables, which are used in building of its identity as a basis for creating value proposition and the position of a brand. Article briefly describes the most comprehensive labeling system for regional products at the micro-regional level is the one guaranteed by Association of Regional Brands (ARB. The main contribution of this article is a theoretical model of strategic management of a regional brand, which captures the interdependence of the individual steps of brand building as well as stakeholders. The starting point for building of brand value is a strategic analysis of the brand, including analysis of customer and competitors. The analysis of external factors is followed by analysis of the brand itself. The resulting relationship between the brand and the customer is based on value proposition representing benefits (functional, emotional, self‑expression. The concept of total product is connected with the concept of total brand and it is offered to the customer as a regional product. Finally it suggests possibilities for further research.

  15. The Economic Value of Water

    Directory of Open Access Journals (Sweden)

    Pedro Arrojo Agudo

    1999-10-01

    Full Text Available The economic term of water is seen from the perspective of an ecological economy, an Aristotelian sense that integrates social values, environmental considerations and financial issues. Water should thus be conceptualized as an “ecosocial” good and not merely as a simple factor of production. Therefore, the focus of water management should not limit itself to managing a scarce resource. Rather the focus should be to articulate an institutional framework that would allow for the use of management tools based on the financial value of water (pricing policies, fiscal incentives, economic penalties for inefficiency... fixed to a somewhat interventionist market, or which answers to administration mechanisms, with constraints setting the conditions of sustainablity that the sound management of water requires in each territory. This approach brings to the table a profoundly territorial andcontextualized view of water management within the paradigm of Sustainable Development. Having said this does not imply disregarding the classical economic science tools of cost/benefit analysis, though. Quite the contrary: today, economic science can provide highly useful, multiple concepts and traditional techniques to the creation of a new model of the economic management of water. At bottom, the challenge is to take advantage of the previous conceptual and methodological body of work, refining the work in some cases,contextualizing it in others, and above all, complementing the previous work with other value-based perspectives to develop a multi-criteria decision-making model for the management and financial assessment of water policies.

  16. ARCHITECTURAL CONCEPTS FOR VALUE CHAINS

    Directory of Open Access Journals (Sweden)

    A.C. Janse van Rensburg

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT:The Porter Value Chain has been widely adopted by the business community as a mechanism to understand and comprehend complexity in business environments, with the ultimate goal of structuring the business to maximize its competitive advantage. Implementing the Value Chain is not easy: a number of organizations can testify to their failure to derive any benefits at all from this concept. To overcome this problem, an approach is presented to assist the organization in creating a Value Chain reference model within the broader context of the organization’s enterprise architecture.

    AFRIKAANSE OPSOMMING: Die “Porter Waardeketting” is ’n algemene aanvaarde praktyk wat deur maatskappye gebruik word om die kompleksiteit van besigheidsomgewings mee te verstaan. Die uiteindelike doel hiervan is om die besigheid se mededings voordele te optimiseer. Om die Waardekettingkonsep te implementeer, is nie ’n maklike taak nie – verskeie organisasies kan getuig van mislukte implementeringspogings. Hierdie artikel beskryf ’n benadering beskryf wat gebruik kan word om die organisasie te help om ’n Waardekettingmodel te skep in die bree konteks van die organisasie se besigheidsargitektuur.

  17. Living the Good (Work) Life: Implications of General Values for Work Values

    Science.gov (United States)

    Carlstrom, Aaron H.

    2011-01-01

    Advances in the understanding of general values from personality and social psychology apply to work values. In this paper, I introduce the concepts of values, value priorities, motivational goals, value types, and personal value systems used to clarify work values. I also introduce the terms basic and broad value and work value types. Second, I…

  18. The School and the Articulation of Values.

    Science.gov (United States)

    Lovin, Robin W.

    1988-01-01

    Value neutrality and values clarification fail to foster critical thinking about values. The values articulation approach identifies the rationality that is applied to value claims. It avoids noncognitivism and moral relativism and suggests ways the discussion of values in the classroom prepares students to deal with broader moral issues. (VM)

  19. Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for (sub)micromolar concentrations of organophosphate insecticides

    NARCIS (Netherlands)

    Meijer, Marieke; Hamers, Timo; Westerink, Remco H S

    Organophosphates (OPs) and carbamates are widely used insecticides that exert their neurotoxicity via inhibition of acetylcholine esterase (AChE) and subsequent overexcitation. OPs can induce additional neurotoxic effects at concentrations below those for inhibition of AChE, indicating other

  20. Structural value of Yerevan streets

    Directory of Open Access Journals (Sweden)

    Avetisyan Arsen Grantovich

    2015-04-01

    Full Text Available The absence of the methods of urban analysis in the process of urban development of Yerevan is the reason of urban planning activities that tend to decrease the urban value of Yerevan territories. Meanwhile the studies in the sphere of urban planning and urban analysis prove the dependence of the life in the city on its structure and distribution of the functions. The mentioned issue highlights the importance of urban analysis. The paper discusses space syntax, which is one of the initial methods of urban analysis. The basic concept of Space syntax is based on the assumption that urban fabric can be presented and studied as a power graph. The method provides the measures that evaluate the land use, traffic and pedestrian movement, land value and even carbon emissions. The paper discusses also recent attempts of integration of space syntax method into GIS environment. GIS databases provide researchers with vast amount of urban data. Analyses presented in the current paper were performed on the basis of the open street map, which was imported from the GIS environment. With the application of space syntax methods analysis of connectivity, integration choice (betweenness and depth from the city center were performed to evaluate the structural value of Yerevan streets. Municipal regions of Yerevan were classified by the level of their accessibility and by their distances from the city center on the base of the results of depth measures from the city center. Evaluation of the street network aims to define the most integrated and centrally positioned parts of the city. These areas can be locations for the organization of sub centers of Yerevan in the municipal regions.

  1. Value and Pricing of MOOCs

    Directory of Open Access Journals (Sweden)

    Rose M. Baker

    2016-05-01

    Full Text Available Reviewed in this article is the potential for Massive Open Online Courses (MOOCs to transform higher education delivery, accessibility, and costs. Next, five major value propositions for MOOCs are considered (headhunting, certification, face-to-face learning, personalized learning, integration with services external to the MOOC, marketing. Then, four pricing strategies for MOOCs are examined (cross-subsidy, third-party, “freemium”, nonmonetary. Although the MOOC movement has experienced growing pains similar to most innovations, we assert that the unyielding pace of improvements in network technologies combined with the need to tame the costs of higher education will create continuing demand for MOOC offerings.

  2. Bivariate value-at-risk

    Directory of Open Access Journals (Sweden)

    Giuseppe Arbia

    2007-10-01

    Full Text Available In this paper we extend the concept of Value-at-risk (VaR to bivariate return distributions in order to obtain measures of the market risk of an asset taking into account additional features linked to downside risk exposure. We first present a general definition of risk as the probability of an adverse event over a random distribution and we then introduce a measure of market risk (b-VaR that admits the traditional b of an asset in portfolio management as a special case when asset returns are normally distributed. Empirical evidences are provided by using Italian stock market data.

  3. UMTRA Project value engineering plan

    International Nuclear Information System (INIS)

    1990-06-01

    The objective of value engineering (VE) on the Uranium MILL Tailings Remedial Action (UMTRA) Project is to ensure that remedial action at the UMTRA Project sites is performed to meet the US Environmental Protection Agency (EPA) standards for inactive uranium mill tailings sites at the lowest cost, while maintaining a high quality of work. Through review of designs and consideration of reasonable, less expensive alternatives, VE can be an effective cost reduction tool and a means to improve the design. The UMTRA Project products are the design and construction of stabilized tailings embankments

  4. Comparison of CIE chromaticity values

    CSIR Research Space (South Africa)

    Van Tonder, N

    1999-02-02

    Full Text Available matter #1999 Elsevier Science B.V. All rights reserved. PII: S0003-2670(98)00526-1 an opal glass white standard. Furthermore, the x and y CIE chromaticity values had to be calculated under the conditions of illuminants A, C and D65 with a 28 observer. 2... to the South African national measuring standards of light by an opal glass re?ectance standard (NPL calibration number AU87) calibrated by the National Physical Laboratory, UK (NPL). Re?ectance measurements were taken at three different positions on each...

  5. The Global Value of Coal

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    Coal plays an essential role in our global energy mix, particularly for power generation; and through that to the alleviation of energy poverty. The use of coal continues to grow rapidly and will continue, together with other fuels, to support world economic and social development particularly in rapidly developing world economies such as China and India. The purpose of this paper is to highlight for policy makers the value of coal to world economic and social development and so encourage development of a policy environment that will allow the coal and electricity industries to make the necessary investments in production capacity and CO2 emissions reduction technologies.

  6. The Marketing of Cultural Values

    Directory of Open Access Journals (Sweden)

    Ionel Enache

    2015-01-01

    Full Text Available The current, fast and unpredictable changes required a rapid transformation of Marketing. Marketing 3.0 can be the solution. Marketing 3.0 is a cultural and social marketing, a marketing of high values: moral, legal, esthetic and a marketing of superior needs: peace, justice, spiritual accomplishments, all globally approached. The goal of Marketing 3.0 is to convince all commercial and cultural structures to get involved in creating the Millennium Development Goals (MDGs: eradicating poverty, access to education, promoting the equality of the sexes, reducing infantile mortality, improving maternal health, fighting diseases, ensuring environment sustainability.

  7. Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors

    DEFF Research Database (Denmark)

    Bräuner-Osborne, Hans; Ebert, B; Brann, M R

    1995-01-01

    = 0.011 microM), and 4d (IC50 = 0.0008 microM). Pharmacological effects (EC50 or Ki values) and intrinsic activities (per cent of maximal carbachol responses) were determined using five recombinant human mAChRs (m1-m5) and the functional assay, receptor selection and amplification technology (R...... inhibitors of the binding of tritiated quinuclidinyl benzilate (QNB), pirenzepine (PZ), and oxotremorine-M (Oxo-M) to tissue membrane preparations. In the [3H]-Oxo-M binding assay, receptor affinities in the low nanomolar range were measured for 4a (IC50 = 0.010 microM), 4b (IC50 = 0.003 microM), 4c (IC50...

  8. Rhetorical values and aesthetic values in Ovid’s Metamorphoses

    Directory of Open Access Journals (Sweden)

    Petre Gheorghe BÂRLEA

    2018-05-01

    Full Text Available Among Ovid’s writings the catalogue of metamorphoses is a literary convention which is more frequent and more significant than it may be thought. The apparently arid formula of the concepts list acquired rhetorical, philosophical, and none the less aesthetic values under Ovid’s pen. The process of acquiring rich and delicately expressed significations enhanced over the time from the lyrical distiches of his youth, such as Amores or Heroides, over to the poems written during his exile, such as Tristia, the climax being the didactic poem in dactylic hexameter Metamorphoses (1-8 AD, unfinished or in any case unperfected. The use of a literary text as support across time and space for his polemics with personalities of the Roman cultural or political world is in accordance with the nonconformist spirit of Publius Ovidius Naso.

  9. Valuing diversity in energy supply

    International Nuclear Information System (INIS)

    Skea, Jim

    2010-01-01

    There is renewed interest in the role of supply diversity in promoting energy security. This paper explores ways of valuing diversity. A possible incentive mechanism for promoting diversity which takes account of underlying 'disparities' between different technology options is developed. The mechanism provides a way of trading off cost and diversity and results in an 'efficient' cost-diversity frontier by analogy with financial portfolio theory. If all technologies are believed to be equally disparate, the appropriate mechanism is a 'levy' imposed on market share. If the technologies are not equally disparate, the levy needs to be adjusted by technology-specific multipliers that take account of levels of disparity and patterns of market share. The analysis is applied to two stylised situations. In the long-run equilibrium case, the implications of both different patterns of disparity and different values attached to diversity are investigated. The paper also explores the implications of applying such a mechanism to the current Great Britain electricity system. The implications in terms of financial flows, for both the market as a whole and for individual operators, are investigated. Finally, the appropriateness of such a mechanism in the light of other policy goals, and possible future research directions, is discussed. (author)

  10. Congruent leadership: values in action.

    Science.gov (United States)

    Stanley, David

    2008-07-01

    To discuss the significance of an appropriate leadership theory in order to develop an understanding of clinical leadership. Leadership theories developed from management and related paradigms, particularly transformational leadership, may be ineffective in supporting nurses to gain insights into clinical leadership or to develop and implement clinical leadership skills. Instead, congruent leadership theory, based on a match between the clinical leaders' actions and their values and beliefs about care and nursing, may offer a more firm theoretical foundation on which clinical nurses can build an understanding of and capacity to implement clinical leadership or become clinical leaders. Evaluation The information used is drawn from the contemporary literature and a study conducted by the author. Leadership can be better understood when an appropriate theoretical foundation is employed. With regard to clinical leadership, congruent leadership is proposed as the most appropriate theory. It is important to recognize that leadership theories based on a management paradigm may not be appropriate for all clinical applications. Education should be aimed specifically at clinical leaders, recognizing that clinical leaders are followed not for their vision or creativity (even if they demonstrate these), but because they translate their values and beliefs about care into action.

  11. Valuing and selling a practice.

    Science.gov (United States)

    Sullivan, Walter

    2012-11-01

    Surgeons, as they contemplate retirement, wrongly believe that their practices do not have financial value. In fact, a well-organized efficiently functioning office with an emphasis on excellent service in combination with a constant stream of patients make it financially ideal for the new surgeon. Being able to assume such a practice can be a very smart financial decision. The practice's worth can be determined by a careful analysis of the practice financials and an evaluation of the functioning of the office and employees. Purchasing such a practice can be, economically, a very smart move by a new surgeon. Payments are made over time at a rate that allows the surgeon to make a good living, leaving him with real equity once the payments are complete. The departing surgeon, who had spent years building this successful practice, gets some of this value back in the form of an income stream to supplement his retirement. This process should be considered in virtually every case. Do not just "close the door."

  12. Total Value of Phosphorus Recovery.

    Science.gov (United States)

    Mayer, Brooke K; Baker, Lawrence A; Boyer, Treavor H; Drechsel, Pay; Gifford, Mac; Hanjra, Munir A; Parameswaran, Prathap; Stoltzfus, Jared; Westerhoff, Paul; Rittmann, Bruce E

    2016-07-05

    Phosphorus (P) is a critical, geographically concentrated, nonrenewable resource necessary to support global food production. In excess (e.g., due to runoff or wastewater discharges), P is also a primary cause of eutrophication. To reconcile the simultaneous shortage and overabundance of P, lost P flows must be recovered and reused, alongside improvements in P-use efficiency. While this motivation is increasingly being recognized, little P recovery is practiced today, as recovered P generally cannot compete with the relatively low cost of mined P. Therefore, P is often captured to prevent its release into the environment without beneficial recovery and reuse. However, additional incentives for P recovery emerge when accounting for the total value of P recovery. This article provides a comprehensive overview of the range of benefits of recovering P from waste streams, i.e., the total value of recovering P. This approach accounts for P products, as well as other assets that are associated with P and can be recovered in parallel, such as energy, nitrogen, metals and minerals, and water. Additionally, P recovery provides valuable services to society and the environment by protecting and improving environmental quality, enhancing efficiency of waste treatment facilities, and improving food security and social equity. The needs to make P recovery a reality are also discussed, including business models, bottlenecks, and policy and education strategies.

  13. Economic Values and Resource Use

    Directory of Open Access Journals (Sweden)

    Jan Mikael Malmaeus

    2016-05-01

    Full Text Available Absolute decoupling of GDP growth from resource use implies that economic output can be increased without simultaneously increasing input. The essential meaning of this proposition is that the economic values that represent the GDP can be realized by increasing resource efficiency. Given that the GDP is first and foremost a measure of economic activity rather than welfare the possibility of absolute decoupling is theoretically limited. This paper demonstrates theoretically and empirically that economic values at the macroeconomic level are fundamentally determined by the use of production factors, primarily labor and physical capital. Technical innovations or efficiency gains increasing utility without raising the costs of production do not add to the GDP unless they stimulate investments in physical capital. Hence the neoclassical notion of productivity is only found to be relevant as a microeconomic concept. In practice, GDP growth is mostly explained by capital accumulation and a key question is whether or not capital accumulation can be decoupled from the use of materials and energy. This will determine the possibility of decoupling of GDP growth from resource use and environmental impact. Alternative measures of progress focusing on welfare rather than economic activity are more likely to achieve absolute decoupling.

  14. Expectation values in quantum gravity

    International Nuclear Information System (INIS)

    Jordan, R.D.

    1986-01-01

    The purpose of this dissertation is to develop new methods for calculating expectation values of field operators, in situations where particle creation is important. The goal is to apply these techniques to quantum gravity, to see if the initial singularity in the universe might be avoided in the quantum theory. Standard effective action theory is modified to produce effective field equations satisfied by the expectation value of the field in an in state, as opposed to the usual in-out amplitude. Diagrammatic rules are found for calculation of the new field equations, and are used to show that the equations are real and causal up to two loop order. The theory also provides a simple check of unitarity, which is carried out, again up to two loops. Just as the standard effective field equations can be derived by analytic continuation from a theory defined in Euclidean space, so can the modified equations be obtained from a modified contour rotation of the Euclidean theory. This result is used to prove a recent conjecture which yields a simple rule for finding the real, causal equations. The new formalism is applied to two gravitational systems. First, the stability of flat space time is studied by finding the equation satisfied by small perturbations of Minkowski space

  15. Cultural Values and Overall Fairness;

    Directory of Open Access Journals (Sweden)

    Mohsen Golparvar

    2010-04-01

    Full Text Available This research conducted with the aim of investigating the relationships between overall fairness and cultural values with organizational justice, job satisfaction and turnover among the personnel of training and education administrations in Esfahan city. Statistical population were the personnel of education and training administrations regions, which 309 persons from them selected with using simple random sampling. Research instruments were overall fairness with 3 items, cultural values (in two fields including materialism and power distance with 8 items, distributive, procedural and interactional justice with 3,3,3 items respectively, job satisfaction with 3 items and turnover with 3 items. Data were analyzed with using Pearson’s correlation coefficient, structural equation modeling, moderated hierarchical regression and mediating regression analysis. Results showed that there are significant relations between overall fairness with distributive, procedural, interactional justice and turnover, job satisfaction and materialism (P0.05. The results of structural equation modeling and mediating regression analysis showed that overall fairness relatively mediate the relations between procedural justices with turnover. But there was not mediated role for overall fairness in relations between distributive and interactional fairness with turnover and job satisfaction. Moderated regression analysis showed that power distance likely have moderated role in relations between overall fairness with turnover likely.

  16. Ethical values in radiological protection

    International Nuclear Information System (INIS)

    Oughton, D.H.

    1996-01-01

    Issues like consent, equity, control and responsibility are important for an ethical evaluation of radiation risks. This paper discusses the incorporation of ethical values in radiological protection policy and compares how ICRP recommendations promote their use in practice and intervention cases. The paper contends that in cases of intervention, where the overall aim is dose reduction, social and ethical factors are often alluded to when evaluating costs of an action. However, possible ethical or social benefits of intervention measures are seldom raised. On the other hand, when assessing a practice, wherein the net effect is an increase in radiation dose, one is more likely to find an appeal to ethical factors on the benefits side of the equation than with the costs. The paper concludes that all decisions concerning radiological protection should consider both positive and negative ethical aspects. (author)

  17. Production of hydrocarbons of value

    Energy Technology Data Exchange (ETDEWEB)

    1931-06-16

    A process is described for the production of hydrocarbons of great value by treating with heat and pressure carbonaceous materials such as coals, tars, mineral oils, and products of distillation and transformation of these materials, also for the refining with heat and pressure of mixed liquid hydrocarbons by means of hydrogen gas, preferably in the presence of catalysts, consisting in using as the hydrogenating gas that obtained by gasification of combustible solids after partial or complete cleaning at atmospheric or elevated pressures, by means of solid adsorbents, chemical agents or catalysts, or mixtures of these agents, the hydrocarbons being characterized by strong unsaturation, and the presence of oxygen, sulfur compounds, and oxides of nitrogen.

  18. Shale Oil Value Enhancement Research

    Energy Technology Data Exchange (ETDEWEB)

    James W. Bunger

    2006-11-30

    Raw kerogen oil is rich in heteroatom-containing compounds. Heteroatoms, N, S & O, are undesirable as components of a refinery feedstock, but are the basis for product value in agrochemicals, pharmaceuticals, surfactants, solvents, polymers, and a host of industrial materials. An economically viable, technologically feasible process scheme was developed in this research that promises to enhance the economics of oil shale development, both in the US and elsewhere in the world, in particular Estonia. Products will compete in existing markets for products now manufactured by costly synthesis routes. A premium petroleum refinery feedstock is also produced. The technology is now ready for pilot plant engineering studies and is likely to play an important role in developing a US oil shale industry.

  19. The value of preoperative planning.

    Science.gov (United States)

    Graves, Matt L

    2013-10-01

    "Better to throw your disasters into the waste paper basket than to consign your patients to the scrap heap" has been a proverb of Jeff Mast, one of the greatest fracture and deformity surgeons in the history of our specialty. Stated slightly more scientifically, one of the major values of simulation is that it allows one to make mistakes in a consequence-free environment. Preoperative planning is the focus of this article. The primary goal is not to provide you with a recipe of how to steps. Rather, the primary goal of this article is to explain why preoperative planning should be standard, to clarify what should be included, and to provide examples of what can happen when planning is ignored. At the end of this, we should all feel the need to approach fracture care more intellectually with forethought, both in our own practices and in our educational system.

  20. Value in assessing new vaccines

    Directory of Open Access Journals (Sweden)

    Giuseppe La Torre

    2009-09-01

    Full Text Available Vaccination strategies are recognised as one of the most powerful interventions in the field of Public health worldwide, capable of reducing both morbidity and mortality. There is wide availability of new vaccines, at least in Developed Countries, that have the potential to control infectious diseases, while on the other hand there are new vaccines that will become available in the next few years. This paper aims to describe the different perspectives one could take into account in valuing particularly new vaccines. The epidemiological approach has been one of underlying principles in setting priorities for immunization programs. The introduction in the health market of a new vaccine is based on the assessment of the related burden of infection/disease and the consequent impact on population health. In the economic evaluation approach several types of analysis are available. The budget impact analysis is concerned more with the immediate impact; in this sense cost is considered instead of value as well as giving higher consideration to short-term effects, while cost-effectiveness or cost-utility analysis can be utilised to examine effects in the long term. In the field of vaccinations a public approach through the use of media campaigns or non-profit organisations, might or might not push politicians and physicians to take action to address a perceived health problem via a vaccine. A Health Technology Assessment approach has been developed in some European countries to examine, in a multidisciplinary way, the clinical, economic, organizational, ethical, juridical, social and cultural implications of the introduction or the implementation of a specific technology. The HTA approach in Italy was demonstrated to be a comprehensive tool in assessing the introduction of a new vaccine, giving insight to the issue to several stakeholders, i.e. decision makers, researchers, and patients.

  1. Gasification : converting low value feedstocks to high value products

    International Nuclear Information System (INIS)

    Koppel, P.; Lorden, D.

    2009-01-01

    This presentation provided a historic overview of the gasification process and described the process chemistry of its two primary reactions, notably partial oxidation and steam reforming. The gasification process involves converting low value carbonaceous solid or liquid feeds to a synthetic gas by reacting the feed with oxygen and steam under high pressure and temperature conditions. Since the gasifier operates under a reducing environment instead of an oxidizing environment, mist sulphur is converted to hydrogen sulphide instead of sulphur dioxide. The gasification process also involves cleaning up synthetic gas and acid gas removal; recovery of conventional sulphur; and combustion or further processing of clean synthetic gas. This presentation also outlined secondary reactions such as methanation, water shift, and carbon formation. The negative effects of gasification were also discussed, with particular reference to syngas; metal carbonyls; soot; and slag. Other topics that were presented included world syngas production capacity by primary feedstock; operating IGCC projects; natural gas demand by oil sands supply and demand considerations; reasons for using the gasification process; gasifier feedstocks; and gasification products. The presentation concluded with a discussion of gasification licensors; gasification technologies; gasification experience; and the regulatory situation for greenhouse gas. Gasification has demonstrated excellent environmental performance with sulphur recovery greater than 99 per cent, depending on the the recovery process chosen. The opportunity also exists for carbon dioxide recovery. tabs., figs.

  2. Do We Really Value Learning?

    Science.gov (United States)

    Moore, John W.

    1999-01-01

    University faculty think of their institutions as places in which learning is valued and pride themselves on the discovery of new knowledge. Indeed universities have been unusually successful in supporting research and developing new knowledge that has been enormously beneficial to society, and university faculty value learning far more than the average. But some kinds of learning are more valued than others-a fact that I believe is detrimental to the long-term welfare of both universities and society. By far the most valued learning is by someone who discovers what nobody else has learned before. We call the process of achieving such learning "research". It is the coin of the academic realm, at least partly because it is easy to evaluate. Those who do it creatively can reap the rewards of respect from their colleagues, better facilities and instrumentation from their institutions, regional and national awards from their disciplinary societies, and increased funding from government and industry for their endeavors. Significantly less valued are activities that help others to learn, especially when the learning involves things already known by many. We call such activities "teaching", although the dictionary definition of "teach" ("to show how to do something; give instructions to; train") is not broad enough to encompass the range of activities currently being used to encourage learning. There is a widespread notion that teaching is easy and requires no real creativity. Nontenured faculty are often warned that time spent on teaching will be thought of as "wasted", and those well established in research have been criticized for spending too much of their time on the "unproductive" activity of teaching. Teaching is held out to students as a fall-back position in case their other career plans do not pan out, and sometimes those who educate teachers are willing to accept less than the highest quality from the students to whom they provide credentials. Those who employ

  3. Synthesis and antiviral activities of a novel class of thioflavone and flavonoid analogues

    Directory of Open Access Journals (Sweden)

    Dajun Zhang

    2012-12-01

    Full Text Available A novel class of thioflavone and flavonoid derivatives has been prepared and their antiviral activities against enterovirus 71 (EV71 and the coxsackievirus B3 (CVB3 and B6 (CVB6 were evaluated. Compounds 7d and 9b showed potent antiviral activities against EV71 with IC50 values of 8.27 and 5.48 μM, respectively. Compound 7f, which has been synthesized for the first time in this work, showed the highest level of inhibitory activity against both CVB3 and CVB6 with an IC50 value of 0.62 and 0.87 μM. Compounds 4b, 7a, 9c and 9e also showed strong inhibitory activities against both the CVB3 and CVB6 at low concentrations (IC50=1.42−7.15 μM, whereas compounds 4d, 7c, 7e and 7g showed strong activity against CVB6 (IC50=2.91–3.77 μM together with low levels of activity against CVB3. Compound 7d exhibited stronger inhibitory activity against CVB3 (IC50=6.44 μM than CVB6 (IC50>8.29 μM. The thioflavone derivatives 7a, 7c, 7d, 7e, 7f and 7g, represent a new class of lead compounds for the development of novel antiviral agents.

  4. The Anti-trichomonas Activity of Berberine by Applying the Bromocresol Purple Colorimetric Spectroscopic Assay in vitro%溴甲酚紫法测定黄连素的体外抗阴道毛滴虫作用

    Institute of Scientific and Technical Information of China (English)

    陈熙; 周本江

    2013-01-01

    目的 溴甲酚紫法体外测试黄连素的抗阴道毛滴虫活性.方法 设计实验组、已知疗效对照组和阴性对照组,溴甲酚紫比色法体外测定药物作用于阴道毛滴虫后不同时间、不同药物浓度的培养基OD值,经线性回归分析,绘制IC50曲线图,进行药效学比较分析.结果 药物作用早期(2 h),黄连素IC50值高于甲硝唑;4~6h2种药物的IC50值较接近,12 h时,甲硝唑的IC50值为11.64 μg/mL,黄连素的IC50值为10.58 μg/mL,24 h,黄连素、甲硝唑的IC50值继续下降,在9.53~9.61 μg/mL之间.48 h,两药的IC50值在5.38~6.03 μg/mL之间,黄连素IC50值稍高.结论 黄连素体外抗阴道毛滴虫的活性与甲硝唑相当,作为治疗阴道毛滴虫感染或治疗耐甲硝唑虫株的替代药物,具有很好的开发利用前景.%Objective To test in vitro the anti-trichomonas vaginalis activity of berberine by bromocresol purple assay.Methods The Trichmonas vaginals in experimental group,known-efficacy group and negative group,were tested by applying the bromocresol purple colorimetric spectroscopic assay.Before and after the treatment,the OD values of culture medium were measured at different times to make the linear regression analysis and draw IC50 curves.Results Compared at the earlier incubation period (2 h),the IC50 value of berberine was higher than that of metronidazole.During the 4 h and 6 h,the IC50 values of two medicaments were similar.At 12 h,the IC50 value of metronidazole was 11.64 μg/mL and that of berberine was 10.58 μg/mL.At 24 h,the the IC50 values of two medicaments kept decreasing,were between 9.53 and 9.61 μg/mL.At 48 h,the IC50 values of two medicaments were between 5.38 and 6.03 μg/mL while the IC50 value of berberine was higher.Conclusion The berberine has similar anti-trichomonas vaginalis activity with metronidazole,and can substitute metronidazole in treating the trichomonas vaginalis infection and the metronidazole-resistant strains infection

  5. The Value of Information in Library Catalogs.

    Science.gov (United States)

    Matthews, Joe

    2000-01-01

    Considers the value of information contained within a library's online public access catalog. Assesses the value of MARC records; authority records; indexes; location and status information; and value for an individual. (LRW)

  6. Issues in Fair Value Accounting under IFRS

    OpenAIRE

    Bischof, Jannis

    2008-01-01

    The dissertation presents theoretical evidence for inconsistencies in fair value accounting under IFRS, experimental evidence for biases in risk perception of fair values and empirical evidence for discretion in banks' disclosure policies with respect to fair value measurement.

  7. Gap Analysis: Application to Earned Value Analysis

    OpenAIRE

    Langford, Gary O.; Franck, Raymond (Chip)

    2008-01-01

    Sponsored Report (for Acquisition Research Program) Earned Value is regarded as a useful tool to monitor commercial and defense system acquisitions. This paper applies the theoretical foundations and systematics of Gap Analysis to improve Earned Value Management. As currently implemented, Earned Value inaccurately provides a higher value for the work performed. This preliminary research indicates that Earned Value calculations can be corrected. Value Analysis, properly defined and enacted,...

  8. Customer's potential value: The role of learning

    OpenAIRE

    Komulainen, Hanna; Mainela, Tuija; Tähtinen, Jaana

    2013-01-01

    Current views on value creation emphasize the role of the customer, mutual investments, and value co-creation. Nevertheless, at present the customer-focused research concentrates on value expectations and value experiences as outcomes but disregards the analysis of potential value that is dependent on the customer's activity and learning in the process. The present study explores customer perceived value as a multidimensional phenomenon incorporating expected, realized, and potential dimensio...

  9. Where lean construction and value management meet

    OpenAIRE

    Musa, MM; Pasquire, C; Hurst, A

    2016-01-01

    The lean construction (LC) community’s key vision and goal is to provide value, yet they are increasingly challenged with understanding and dealing with the concept of value, with reports that value is one of the weakest points. Regardless of the previous studies and contributions already made on the concept of value in LC, the absence of a consistent understanding of value has resulted in misperceptions and indistinct boundaries with other construction value-related disciplines. Without a co...

  10. Individual differences in valuing mates' physical attractiveness.

    Science.gov (United States)

    Mathes, Eugene W; Bielser, Abby; Cassell, Ticcarra; Summers, Sarah; Witowski, Aggie

    2006-10-01

    To investigate correlates of valuing physical attractiveness in a mate, it was hypothesized that valuing physical attractiveness in a mate would correlate with sex and valuing promiscuous sex, status, personal physical attractiveness, beauty, and order. Men and women college students completed measures of the extent to which they valued physical attractiveness in a mate and other variables. Valuing physical attractiveness in a mate was correlated with sex (men valued physical attractiveness in a mate more than did women) and valuing promiscuous sex and status, and, for women, valuing personal physical attractiveness. The results were explained in terms of evolutionary theory.

  11. More Value through Greater Differentiation: Gender Differences in Value Beliefs about Math

    Science.gov (United States)

    Gaspard, Hanna; Dicke, Anna-Lena; Flunger, Barbara; Schreier, Brigitte; Häfner, Isabelle; Trautwein, Ulrich; Nagengast, Benjamin

    2015-01-01

    Expectancy-value theory (Eccles et al., 1983) is a prominent approach to explaining gender differences in math-related academic choices, with value beliefs acting as an important explanatory factor. Expectancy-value theory defines 4 value components: intrinsic value, attainment value, utility value, and cost. The present study followed up on…

  12. Printing Values In Interactive ROOT

    CERN Document Server

    Perovic, Boris

    2015-01-01

    This project report summarizes the work I have been performing during the past twelve weeks as a Summer Student intern working on ROOT project in the SFT group, PH department, under the supervision of Axel Naumann and Danilo Piparo. One of the widely requested features for ROOT was improved interactive shell experience as well as improved printing of object values. Solving this issue was the goal of this project. Primarily, we have enabled printing of the collections. Secondly, we have unified the printing interface, making it much more robust and extendible. Thirdly, we have implemented printing of nested collections in a flexible and user-friendly manner. Finally, we have added an interactive mode, allowing for paginated output. At the beginning of the report, ROOT is presented with examples of where it is used and how important it is. Then, the motivation behind the project is elaborated, by presenting the previous state of the software package and its potential for improvement. Further, the process in wh...

  13. New Value: Keeping It Real

    Directory of Open Access Journals (Sweden)

    Peter Chamberlain

    2014-10-01

    Full Text Available Many parts of the world now swim in a sea of complex products that do not necessarily improve the overall quality of our lives. From cell phones to baby strollers, we have overloaded our designed environment with hyper-functional products that often leave us searching for simpler, straighter forward product offerings. In a product landscape that more often than not equates complexity with sophistication; our ever-increasingly complex modern society has allowed faux conveniences to outweigh the tangible realness of our experiences. The look and feel of products has often become complex and complicated – and this is often highlighted as a positive thing. We are less likely to encounter simple, intuitive, and usable products geared toward the individual. To avoid this trap, one would need to apply a filter that would govern the intake of certain products to only those that are seen as adding true value to our lives. It is necessary to appeal to people’s emotions, and carry cultural richness and authenticity back to the forefront while embracing the power of cur-rent and future technologies. Design has tremendous power and the versatility necessary to bring about this positive change.

  14. 'New’ literacies: technologies and values

    Directory of Open Access Journals (Sweden)

    Colin Lankshear

    2012-12-01

    Full Text Available It is too easy to make light of ‘new literacies’ by saying things like: “Well, there are always newer ones coming along”. Such remarks suggest new literacies have a similar kind of life trajectory to an automobile: new in 2009, semi-new in 2010, and old hat by 2011. Against this kind of “that’s so yesterday” perspective, we suggest in this article that ‘new literacies’ are best understood in terms of an historical period of social, cultural, institutional, economic, and intellectual change that is likely to span many decades – some of which are already behind us. We associate new literacies with an historical conjuncture and an ascending social paradigm. From this perspective we suggest that the kinds of practices we currently identify as new literacies will cease to be ‘new’ once the social ways characterizing the ascending paradigm have become sufficiently establised and grounded to be regarded as conventional. Furthermore we suggest that at the heart of the idea of new ethos stuff is the idea of technological change aligning with a range of increasingly popular values.

  15. Morton neuroma: MRI diagnostic value

    International Nuclear Information System (INIS)

    Yelin, Enrique G.; Aparicio, Rocio; Dutto, Santiago; Rodriguez Lucero, Javier

    2004-01-01

    Objective: To evaluate the diagnostic value of MRI in Morton's Neuroma (MN). Material and methods: 23 patients with clinical diagnosis of MN were examined under two different protocols, with a 1.5 T Magnet. 1) T1, FSET2, FIR, T1 with contrast enhancement and fat suppression; 2) T1, FSET2, FIR without contrast enhancement (i.v. Gadolinium). Results: In the first group MN was found in 7 patients. In the second group 14 patients were studied, 7 with positive MR for neuroma, and 9 with negative MR. 6 were true-negative and 3 were false-negative. The Fisher Test between both groups was p < 0.05. Conclusion: MRI is effective for the diagnosis of Morton neuroma. The use of gadolinium and fat suppression significantly improved the detection of Morton neuroma, allowing better measurements of the lesion. These findings do not correlate with previous papers that do not encourage the use of i.v. Gadolinium. (author)

  16. Values and education: Russian perspective

    Directory of Open Access Journals (Sweden)

    Borytko Nikolai M.

    2005-01-01

    Full Text Available This article is about some lessons of the multi-cultural analysis of a joint Russian-British educational project. The analysis, based on the achievements of Russian pedagogical science, about the achievement of the most effective cross-cultural communication, can be listed among the outcomes of the project, along with the applied results, which consists in developing an educational management training program. The growth of innovation process and international contacts in education testifies to the fact that education culture is evolving toward a new quality. In the evolution/process, the basic needs of schools, teachers and education managers are identified and conceptualized. Sharing achievements and discoveries in professional growth should be kept in mind and that fulfilling the needs can only take place within the context of the cultural-pedagogic position inherent to an individual teacher, a group of teachers, or a school. From the point of view of cross-cultural analysis, the specifics lie in the inherent values and the level at which the activity is typically performed. This analysis equips the researcher with the criteria necessary for identifying the culture type dealt with. This latter can be used then as a tool for analyzing and designing innovations.

  17. The Value of Landscape Essence

    Directory of Open Access Journals (Sweden)

    Maria da Conceição Marques Freire

    2014-08-01

    Full Text Available A new approach to interpreting the landscape is examined by accepting its complexity through inductive reasoning. While attempting to identify the essence of the landscape in the city and municipality of Óbidos, Portugal, several architectural recommendations of Venturi (2004 have been adapted as a framework for understanding this landscape. These will then guide the process of landscape transformation through:•••using the concepts of closed and contained spaces and the concept of fluid space;•recognising the existence of interstitial open spaces;•using those elements which are common to the distinct typologies of space;•defining the components that should be respected and those that can be respected;•observing landscape as a whole , while emphasising the relationship between the parts and the whole; and•rejecting simplification in the landscape transformation process.valuing the ambiguity incorporating the complexity Underlying this approach is the belief that the process of transformation must be based on the essence of each landscape. This implies the use of elements and structures of the landscape which are related to ecological, morphological and cultural systems. These elements and structures represent points of reference which should be considered in the process of landscape transformation.

  18. Malaysian brown seaweeds Sargassum siliquosum and Sargassum polycystum: Low density lipoprotein (LDL) oxidation, angiotensin converting enzyme (ACE), α-amylase, and α-glucosidase inhibition activities.

    Science.gov (United States)

    Nagappan, Hemlatha; Pee, Poh Ping; Kee, Sandra Hui Yin; Ow, Ji Tsong; Yan, See Wan; Chew, Lye Yee; Kong, Kin Weng

    2017-09-01

    Two Malaysian brown seaweeds, Sargassum siliquosum and Sargassum polycystum were first extracted using methanol to get the crude extract (CE) and further fractionated to obtain fucoxanthin-rich fraction (FRF). Samples were evaluated for their phenolic, flavonoid, and fucoxanthin contents, as well as their inhibitory activities towards low density lipoprotein (LDL) oxidation, angiotensin converting enzyme (ACE), α-amylase, and α-glucosidase. In LDL oxidation assay, an increasing trend in antioxidant activity was observed as the concentration of FRF (0.04-0.2mg/mL) and CE (0.2-1.0mg/mL) increased, though not statistically significant. As for serum oxidation assay, significant decrease in antioxidant activity was observed as concentration of FRF increased, while CE showed no significant difference in inhibitory activity across the concentrations used. The IC 50 values for ACE inhibitory activity of CE (0.03-0.42mg/mL) were lower than that of FRF (0.94-1.53mg/mL). When compared to reference drug Voglibose (IC 50 value of 0.61mg/mL) in the effectiveness in inhibiting α-amylase, CE (0.58mg/mL) gave significantly lower IC 50 values while FRF (0.68-0.71mg/mL) had significantly higher IC 50 values. The α-glucosidase inhibitory activity of CE (IC 50 value of 0.57-0.69mg/mL) and FRF (IC 50 value of 0.50-0.53mg/mL) were comparable to that of reference drug (IC 50 value of 0.54mg/mL). Results had shown the potential of S. siliquosum and S. polycystum in reducing cardiovascular diseases related risk factors following their inhibitory activities on ACE, α-amylase and α-glucosidase. In addition, it is likelihood that FRF possessed antioxidant activity at low concentration level. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Value of preoperative cervical discography

    International Nuclear Information System (INIS)

    Kwon, Jong Won; Kim, Sung Hyun; Lee, Joon Woo

    2006-01-01

    The aim of this study was to describe the method and the value of cervical discography as correlated with the MR findings. Twenty-one discs in 11 consecutive patients who underwent cervical discography were analyzed. MR and CT discography (CTD) were performed in all patients. Discography was performed after swallowing barium for visualizing the pharynx and the esophagus to prevent penetration. We also analyzed the preceding causes of the subjects' cervical pain. The results of the pain provocation test were classified into concordant pain, discordant pain and a negative test. MRI was analyzed according to the T2-signal intensity (SI) of the disc, disc height, annular bulging and disc herniation. The CTD was analyzed for degeneration or radial tear of the disc, epidural leakage of the contrast agent and pooling of the contrast agent at the periphery of the disc. The pain provocation tests were correlated with the MR and CTD findings. We used the chi-square test to analyze the results. Concordant pain was observed in 14 cases, discordant pain in 3 cases and there were negative tests in 4 cases. There were no complications related to the procedure. Four patients had undergone anterior cervical fusion and four patients that developed after traffic injuries. The decreased T2-SI and annular bulging on MRI, disc degeneration and peripheral pooling of the contrast agent on CT were significantly correlated with pain provocation. When the diagnosis of disc disease is difficult with performing MRI, cervical discography with using swallowed barium solution to reduce the penetration of the esophagus or hypopharynx may play be helpful. The decreased T2-SI and annular bulging on MRI correlated significantly with a positive result on the pain provocation test

  20. ON BIPOLAR SINGLE VALUED NEUTROSOPHIC GRAPHS

    OpenAIRE

    Said Broumi; Mohamed Talea; Assia Bakali; Florentin Smarandache

    2016-01-01

    In this article, we combine the concept of bipolar neutrosophic set and graph theory. We introduce the notions of bipolar single valued neutrosophic graphs, strong bipolar single valued neutrosophic graphs, complete bipolar single valued neutrosophic graphs, regular bipolar single valued neutrosophic graphs and investigate some of their related properties.

  1. Mean value theorem in topological vector spaces

    International Nuclear Information System (INIS)

    Khan, L.A.

    1994-08-01

    The aim of this note is to give shorter proofs of the mean value theorem, the mean value inequality, and the mean value inclusion for the class of Gateaux differentiable functions having values in a topological vector space. (author). 6 refs

  2. Students' Reasoning about p-Values

    Science.gov (United States)

    Aquilonius, Birgit C.; Brenner, Mary E.

    2015-01-01

    Results from a study of 16 community college students are presented. The research question concerned how students reasoned about p-values. Students' approach to p-values in hypothesis testing was procedural. Students viewed p-values as something that one compares to alpha values in order to arrive at an answer and did not attach much meaning to…

  3. The consumption values' influence on smartphone's ownership

    DEFF Research Database (Denmark)

    Petrovcikova, Katarina; Sudzina, Frantisek

    2016-01-01

    The aim of the paper was to analyze impact of factors on adoption of smartphones using the Theory of Consumption Values framework. The Theory of Consumption Values provides a framework to categorize customer's motives for buying; it divides them into five groups: functional values, social values,...

  4. Quantifying forecast quality of IT business value

    NARCIS (Netherlands)

    Eveleens, J.L.; van der Pas, M.; Verhoef, C.

    2012-01-01

    This article discusses how to quantify the forecasting quality of IT business value. We address a common economic indicator often used to determine the business value of project proposals, the Net Present Value (NPV). To quantify the forecasting quality of IT business value, we develop a generalized

  5. The Education of Developing Responsibility Value

    Science.gov (United States)

    Güngör, Semra Kiranli; Güzel, Deniz Bostan

    2017-01-01

    The aim of this research is to improve different responsibility value education activities in pre-school value education. In Turkey, there is a yearly programme in which value should be gained in pre-school value education, but it is lack of activities and how. This research was performed with the studies in a total of 26 students aged five and…

  6. Record Values of a Pareto Distribution.

    Science.gov (United States)

    Ahsanullah, M.

    The record values of the Pareto distribution, labelled Pareto (II) (alpha, beta, nu), are reviewed. The best linear unbiased estimates of the parameters in terms of the record values are provided. The prediction of the sth record value based on the first m (s>m) record values are obtained. A classical Pareto distribution provides reasonably…

  7. Organizational Imperatives for Implementing the Essential Values.

    Science.gov (United States)

    Dalton, Jon C.

    1993-01-01

    Examines the role of student affairs leaders in transmitting and in using values to build a values-centered organization and leadership style. Argues that values issues are inescapable and suggests five education strategies that leaders of student affairs organizations can use to enhance the right values in student affairs. (RJM)

  8. 7 CFR 1437.301 - Value loss.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Value loss. 1437.301 Section 1437.301 Agriculture... Coverage Using Value § 1437.301 Value loss. (a) Special provisions are required to assess losses and.... Assistance for these commodities is calculated based on the loss of value at the time of disaster. The agency...

  9. 19 CFR 152.106 - Computed value.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Computed value. 152.106 Section 152.106 Customs... (CONTINUED) CLASSIFICATION AND APPRAISEMENT OF MERCHANDISE Valuation of Merchandise § 152.106 Computed value. (a) Elements. The computed value of imported merchandise is the sum of: (1) The cost or value of the...

  10. 7 CFR 1230.14 - Market value.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Market value. 1230.14 Section 1230.14 Agriculture... value. Market value means, with respect to porcine animals which are sold, the price at which they are... imported porcine animals, the term means the declared value. With respect to imported pork and pork...

  11. Toxicity evaluation and prediction of toxic chemicals on activated sludge system.

    Science.gov (United States)

    Cai, Bijing; Xie, Li; Yang, Dianhai; Arcangeli, Jean-Pierre

    2010-05-15

    The gaps of data for evaluating toxicity of new or overloaded organic chemicals on activated sludge system resulted in the requirements for methodology of toxicity estimation. In this study, 24 aromatic chemicals typically existed in the industrial wastewater were selected and classified into three groups of benzenes, phenols and anilines. Their toxicity on activated sludge was then investigated. Two indexes of IC(50-M) and IC(50-S) were determined respectively from the respiration rates of activated sludge with different toxicant concentration at mid-term (24h) and short-term (30min) time intervals. Experimental results showed that the group of benzenes was the most toxic, followed by the groups of phenols and anilines. The values of IC(50-M) of the tested chemicals were higher than those of IC(50-S). In addition, quantitative structure-activity relationships (QSARs) models developed from IC(50-M) were more stable and accurate than those of IC(50-S). The multiple linear models based on molecular descriptors and K(ow) presented better reliability than single linear models based on K(ow). Among these molecular descriptors, E(lumo) was the most important impact factor for evaluation of mid-term toxicity. Copyright (c) 2009 Elsevier B.V. All rights reserved.

  12. The concept and structure of personal values

    Directory of Open Access Journals (Sweden)

    Vid Pogačnik

    2002-02-01

    Full Text Available The revised Personal Values Scale now consists of 24 values, representing 24 basic human motives. It was given to 595 students and adults. Relations among values were analysed by techniques of multivariate analysis. The results show that, despite of weak intercorrelations among personal values, the values space is structured by two bipolar values macrodimensions (dionisian–apolinian, existential–fulfillment and that also clusters of narrow range exist. The results were discussed and compared with Musek's structure model. A new model of personal values is presented.

  13. Social values as arguments: similar is convincing

    Science.gov (United States)

    Maio, Gregory R.; Hahn, Ulrike; Frost, John-Mark; Kuppens, Toon; Rehman, Nadia; Kamble, Shanmukh

    2014-01-01

    Politicians, philosophers, and rhetors engage in co-value argumentation: appealing to one value in order to support another value (e.g., “equality leads to freedom”). Across four experiments in the United Kingdom and India, we found that the psychological relatedness of values affects the persuasiveness of the arguments that bind them. Experiment 1 found that participants were more persuaded by arguments citing values that fulfilled similar motives than by arguments citing opposing values. Experiments 2 and 3 replicated this result using a wider variety of values, while finding that the effect is stronger among people higher in need for cognition and that the effect is mediated by the greater plausibility of co-value arguments that link motivationally compatible values. Experiment 4 extended the effect to real-world arguments taken from political propaganda and replicated the mediating effect of argument plausibility. The findings highlight the importance of value relatedness in argument persuasiveness. PMID:25147529

  14. Social Values as Arguments: Similar is Convincing

    Directory of Open Access Journals (Sweden)

    Gregory R Maio

    2014-08-01

    Full Text Available Politicians, philosophers, and rhetors engage in co-value argumentation: appealing to one value in order to support another value (e.g., equality leads to freedom. Across four experiments in the United Kingdom and India, we found that the psychological relatedness of values affects the persuasiveness of the arguments that bind them. Experiment 1 found that participants were more persuaded by arguments citing values that fulfilled similar motives than by arguments citing opposing values. Experiments 2 and 3 replicated this result using a wider variety of values, while finding that the effect is stronger among people higher in need for cognition and that the effect is mediated by the greater plausibility of co-value arguments that link motivationally compatible values. Experiment 4 extended the effect to real-world arguments taken from political propaganda and replicated the mediating effect of argument plausibility. The findings highlight the importance of value relatedness in argument persuasiveness.

  15. The value of snow cover

    Science.gov (United States)

    Sokratov, S. A.

    2009-04-01

    only and not even the main outcome from snow cover use. The value of snow cover for agriculture, water resources, industry and transportation is so naturally inside the activities that is not often quantified. However, any considerations of adaptation strategies for climate change with changing snow conditions need such quantification.

  16. Relevansi Nilai Selisih Loans Book Value dan Loans Fair Value, Book Value Per Share, Earnings Per Share dan Ukuran Perusahaan

    Directory of Open Access Journals (Sweden)

    Dina Bakti Pertiwi

    2015-01-01

    Full Text Available One of the impacts of IFRS convergence is the tendency to leave historical cost to the fair value primarily for financial instruments, one of which is bank loans. Therefore, the benefit of the use of historical cost and fair value needs to be examined. This study aims to evaluate the relationship of the difference between loan book value and fair value, book value per share, earnings per share and the company size to the stock price of banks that use accounting standard that has been converged to IFRS. The samples used are banks listed in Indonesia Stock Exchange during the period of 2010-2013. The relationship between the difference loans book value and fair value, book value per share, earnings per share and the size with the stock price were analyzed using multiple linear regression. The results of this study indicate that the difference between loans book value and fair value, book value per share, earnings per share and the size can be used to predict the stock price of bank. Thus, the difference between loan book value and fair value of financial instruments have a relevant value.

  17. Reconstructing weak values without weak measurements

    International Nuclear Information System (INIS)

    Johansen, Lars M.

    2007-01-01

    I propose a scheme for reconstructing the weak value of an observable without the need for weak measurements. The post-selection in weak measurements is replaced by an initial projector measurement. The observable can be measured using any form of interaction, including projective measurements. The reconstruction is effected by measuring the change in the expectation value of the observable due to the projector measurement. The weak value may take nonclassical values if the projector measurement disturbs the expectation value of the observable

  18. Exploring the professional values of Australian physiotherapists.

    Science.gov (United States)

    Aguilar, Alejandra; Stupans, Ieva; Scutter, Sheila; King, Sharron

    2013-03-01

    A profession's values guide daily practice and professional behaviours. They clarify what professionalism means to a profession, by providing insight into the values that members of the profession aim to uphold and profess. There has been limited research into the values of the Australian physiotherapy profession, and as such, the values that guide practice and constitute professionalism are not explicit. This study aimed to make a preliminary identification of the values of the profession, by exploring the shared professional values of 14 Australian physiotherapists. This study was guided by a qualitative approach and constructivist paradigm. Purposive sampling was employed to identify physiotherapists who could contribute rich information to the study. Semi-structured interviews were conducted and analysed using an inductive data analysis method. The emerging professional values formed three main themes. The first theme, 'the patient and the patient-therapist partnership', incorporated values such as having patient trust and working collaboratively with patients. The theme labelled 'physiotherapy knowledge, skills and practice' included the values of having an evidence base and respecting professional boundaries. The last theme, 'altruistic values', was inclusive of values such as honesty, empathy and caring. The values that emerged went beyond philanthropic values, to values that guided every day practice, professional relationships and the responsibilities of being a professional. The results contribute to research orientated towards identifying the values of the profession and in doing so, clarifying what professionalism means to the Australian physiotherapy profession. Differences between the values identified by the American Physical Therapy Association and the study reported in this paper highlight the importance of identifying the values of the profession within the Australian context. In terms of practice implications, physiotherapists may be prompted to

  19. New Thoughts of Customer Value Study

    Science.gov (United States)

    Sun, Hong; Su, Zhuqing

    Customer value theory's discovery has established to take customer and even customer value as the center position for research of marketing, which is good progress of marketing theory. However, in the past researches for customer value emphasized customer perceived value, there was no good answer on which customers perceived with what scale. This paper states that customer perceived value is established in value transmission mechanism of its rear, which is based on the role of consumption values. With a market environment's change, and the strength of consumer's sovereignty consciousness, especially when personal consumption is identified and developed to become a mainstream consume culture in nowadays society, the role of the transmission is increasingly in evidence. Studies of consumeption values are to deepen customer value theory.

  20. Business marketing: understand what customers value.

    Science.gov (United States)

    Anderson, J C; Narus, J A

    1998-01-01

    How do you define the value of your market offering? Can you measure it? Few suppliers in business markets are able to answer those questions, and yet the ability to pinpoint the value of a product or service for one's customers has never been more important. By creating and using what the authors call customer value models, suppliers are able to figure out exactly what their offerings are worth to customers. Field value assessments--the most commonly used method for building customer value models--call for suppliers to gather data about their customers firsthand whenever possible. Through these assessments, a supplier can build a value model for an individual customer or for a market segment, drawing on data gathered form several customers in that segment. Suppliers can use customer value models to create competitive advantage in several ways. First, they can capitalize on the inevitable variation in customers' requirements by providing flexible market offerings. Second, they can use value models to demonstrate how a new product or service they are offering will provide greater value. Third, they can use their knowledge of how their market offerings specifically deliver value to craft persuasive value propositions. And fourth, they can use value models to provide evidence to customers of their accomplishments. Doing business based on value delivered gives companies the means to get an equitable return for their efforts. Once suppliers truly understand value, they will be able to realize the benefits of measuring and monitoring it for their customers.

  1. Discovery of potent inhibitors of soluble epoxide hydrolase by combinatorial library design and structure-based virtual screening.

    Science.gov (United States)

    Xing, Li; McDonald, Joseph J; Kolodziej, Steve A; Kurumbail, Ravi G; Williams, Jennifer M; Warren, Chad J; O'Neal, Janet M; Skepner, Jill E; Roberds, Steven L

    2011-03-10

    Structure-based virtual screening was applied to design combinatorial libraries to discover novel and potent soluble epoxide hydrolase (sEH) inhibitors. X-ray crystal structures revealed unique interactions for a benzoxazole template in addition to the conserved hydrogen bonds with the catalytic machinery of sEH. By exploitation of the favorable binding elements, two iterations of library design based on amide coupling were employed, guided principally by the docking results of the enumerated virtual products. Biological screening of the libraries demonstrated as high as 90% hit rate, of which over two dozen compounds were single digit nanomolar sEH inhibitors by IC(50) determination. In total the library design and synthesis produced more than 300 submicromolar sEH inhibitors. In cellular systems consistent activities were demonstrated with biochemical measurements. The SAR understanding of the benzoxazole template provides valuable insights into discovery of novel sEH inhibitors as therapeutic agents.

  2. Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas.

    Science.gov (United States)

    Ekoue-Kovi, Kekeli; Yearick, Kimberly; Iwaniuk, Daniel P; Natarajan, Jayakumar K; Alumasa, John; de Dios, Angel C; Roepe, Paul D; Wolf, Christian

    2009-01-01

    We report the synthesis and in vitro antimalarial activities of more than 50 7-chloro-4-aminoquinolyl-derived sulfonamides 3-8 and 11-26, ureas 19-22, thioureas 23-26, and amides 27-54. Many of the CQ analogues prepared for this study showed submicromolar antimalarial activity versus HB3 (chloroquine sensitive) and Dd2 (chloroquine resistant strains of Plasmodium falciparum) and low resistance indices were obtained in most cases. Systematic variation of the side chain length and introduction of fluorinated aliphatic and aromatic termini revealed promising leads that overcome CQ resistance. In particular, sulfonamide 3 exhibiting a short side chain with a terminal dansyl moiety combined high antiplasmodial potency with a low resistance index and showed IC(50)s of 17.5 and 22.7 nM against HB3 and Dd2 parasites.

  3. Values Education in the Mathematics Classroom: Subject Values, Educational Values and One Teacher's Articulation of Her Practice

    Science.gov (United States)

    Bills, Liz; Husbands, Chris

    2005-01-01

    The issue of values has been a longstanding concern of mathematics education research. Attempts have been made to analyze the specifically mathematical values which characterize the practice of mathematics teachers. In this paper we draw on one teacher's articulation of her practice to explore values issues in the teaching of mathematics, drawing…

  4. Value-Based Leadership Approach: A Way for Principals to Revive the Value of Values in Schools

    Science.gov (United States)

    van Niekerk, Molly; Botha, Johan

    2017-01-01

    The qualitative research discussed in this article is based on the assumption that school principals as leaders need to establish, develop and maintain a core of shared values in their schools. Our focus is on principals' current perceptions of values in their schools. This is important because values underpin their decisions and actions and thus…

  5. Market Value Analysis - Urban Redevelopment Authority

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — In late 2016, the URA, in conjunction with Reinvestment Fund, completed the 2016 Market Value Analysis (MVA) for the City of Pittsburgh. The Market Value Analysis...

  6. VALUES AND ATTITUDES TO INNOVATIONS : INTERCULTURAL DIFFERENCES

    NARCIS (Netherlands)

    Lebedeva, N. M.

    2009-01-01

    The results of study of interrelations between values and attitudes to innovations of Canadian and Russian students (Russians and representatives of Northern Caucasia), n = 426 per. are presented. Correlation between individuals' values and their attitudes to innovations are determined. Significant

  7. How spatial context influences entrepreneurial value creation

    DEFF Research Database (Denmark)

    Müller, Sabine

    2014-01-01

    This paper investigates how rural communities are enriched by entrepreneurial value-creating activities that go beyond job creation and growth. In addition, this study explores how spatial context influences these value-creating activities. This qualitative case-based study shows that rural......-being of the community. Thus, this study contributes to an in-depth understanding of how and why entrepreneurship can create multiple forms of value in rural areas as well as how value creation behaviours are motivated by the spatial context. In addition, it provides explanations why not all rural entrepreneurs...... entrepreneurs create 14 types of value for their communities, ranging from purely economic to socioeconomic and to social value. The reasons why rural entrepreneurs create value, not only for themselves, but value that benefits the community is partly explained by their desire to contribute positively...

  8. Value pluralism and incommensurability in Ecological Economics

    DEFF Research Database (Denmark)

    Pirgmaier, Elke; Urhammer, Emil

    2015-01-01

    problems of our time lie in a democracy where multiple values can be communicated. In order to provide inspiration for thinking about such a democracy, this paper provides an overview of a wide range of philosophical positions on values and value pluralism and analyses how values and value pluralism...... territory. This is reflected in a value hegemony framing everything from biodiversity to carbon emissions in monetary terms. We consider this a democratic problem since the diversity of values is thus not fairly represented in our current mode of decision-making. We believe that the solutions to the grand...... are treated in a selection of articles in ecological economics. The paper concludes that the treatment of values and incommensurability in ecological economics can be characterised as ambiguous. There is a need for further research on the theoretical aspects of these issues....

  9. The missing link between values and behaviour

    DEFF Research Database (Denmark)

    Brunsø, Karen

    For a long time human values have been perceived as abstrat cognitions representing desired goals or end-states which motivate humnan behaviour. A number of studies have tried to explore the link between values and behaviour, but often different constructs are included as intermediate links between...... values and specific behaviour, since values may be too abstract to influence behaviour directly. We propose the concept of lifestyle as a mediator between values and behaviour, and present our approach to lifestyle based on principles from cognitive psychology, where we distinguish between values...... and lifestyle and behaviour. Based on this appraoch we collected data covering values, lifestyle and behaviour, and estimated the cogntiive hierarchy from values to lifestyle to behaviour by structural equation models....

  10. On the value of executive management education

    DEFF Research Database (Denmark)

    Tryding, Per

    The thesis explores what values are perceived by participants in four long mid career management programs, whether attending contributes to value added for the participants and their organisations and explores how such value might materialise. Value is defined broadly ranging from direct intangible...... value for participants to indirect tangible value for organisations. The studied uses mixed method with interviews and statistical analysis of a survey. Kirkpatrick's taxonomy of outcomes is used and theoretically linked to value. Both interviews and survey are interpreted and find that two main types...... payback for participants is based on an estimated ability adjustment of 5-10% and assuming all cost is carried by the participants the average time to break even is below 15 years. Also organisational value added is associated with the two kinds of skills development. The pedagogy of the four programs...

  11. Have the Guests Perceived Superior Value?

    Directory of Open Access Journals (Sweden)

    Levyda Levyda

    2017-11-01

    Full Text Available This research aimed to describe guests’ perceived value by using a multidimensional approach. From previous research, guests’ perceived value consisted of some functional value, emotional value, and social value. Based on guest experience, and functional value consisted of physical evidence, guest room, food and beverage, hotel staff, and price. This research was conducted in four-star hotels in Jakarta. The respondents were the guests who had stayed in four-star hotels. The number of the respondent was 405. The data were obtained by using self-administered questionnaires. This research shows that guests have not perceived superior value. Some of the values and the necessary efforts need to be improved.

  12. The contribution of technology to added value

    CERN Document Server

    Fernandes, António S C

    2013-01-01

    There is a wide consensus that introduction of technology to the production process contributes to an overall economic value, however, confusion between technology, knowledge and capital often makes value calculations ambiguous and non-objective. The Contribution of Technology to Added Value addresses not only this issue of definition but also provides a production model to assess the value contribution of technology within the production process. A clarification  of fundamental semantics  provides a significant taxonomy for technology dependence, and allows understanding and modeling of how knowledge, technology and capital individually contribute to production and to value adding. A new technology dependence taxonomy is proposed and assessed following chapters explaining growth models, the KTC model and technology index values. Balancing theoretical knowledge with real-world data and applications The Contribution of Technology to Added Value clarifies the issue of value adding for a range of different vie...

  13. Examining predictive relationships among consumer values: factors ...

    African Journals Online (AJOL)

    Examining predictive relationships among consumer values: factors influencing behavioural intentions in retail purchase in Ghana. ... Journal of Business Research ... effects of age and gender differentials on values among retail consumers.

  14. NUTRITIVE VALUE AND PHYTOCHEMICAL COMPOSITION OF ...

    African Journals Online (AJOL)

    Administrator

    Nutritive Value and Phytochemical Composition of Solanum incanum. NUTRITIVE VALUE ... Proximate analysis: The recommended method of association of analytical ... The result of proximate composition from the present study revealed that ...

  15. Addressing Cancer Drug Costs and Value

    Science.gov (United States)

    The President’s Cancer Panel has released its latest report, Promoting Value, Affordability, and Innovation in Cancer Drug Treatment. The report recommends six actions to maximize the value and affordability of cancer drug treatment.

  16. The nature and impact of personal values and organizational values on customer satisfaction

    OpenAIRE

    BLOEMER, Johanna; Breugelmans, E.; Lievens, Annouk

    2004-01-01

    This exploratory study reports on the nature and impact of personal values, organizational values and value congruence on customer service satisfaction. Customers from a cleaning service organizaton rated 24 values with respect to how important these values were to the organization. The results of hierarchical multiple regression analyses show that organizational values have a predominant impact on customer service satisfaction. The congruence between personal and organizational values and th...

  17. Ecosystem service values for mangroves in Southeast Asia: A meta-analysis and value transfer application

    OpenAIRE

    M. Brander, Luke; J. Wagtendonk, Alfred; S. Hussain, Salman; McVittie, Alistair; Verburg, Peter H.; de Groot, Rudolf S.; van der Ploeg, Sander

    2012-01-01

    This paper examines the value of ecosystem services provided by mangroves. It presents a metaanalysis of the economic valuation literature and applies the estimated value function to assess the value of mangroves in Southeast Asia. We construct a database containing 130 value estimates, largely for mangroves in Southeast Asia. Values are standardised to US$ per hectare per year in 2007 prices. The mean and median values are found to be 4185 and 239 US$/ha/year respectively. The values of mang...

  18. The Value of Children to Iranian Parents

    Directory of Open Access Journals (Sweden)

    Mohammad Taghi Iman

    2007-05-01

    Full Text Available What do parents feel the value of children might be? Using rational choice theory, the effect of having children was measured by their aggregate social, economic and emotional value. The results show that age, gender, occupation and the experience of having raised a child did not correlate with the value of children. However, marital status, family size, family income and especially religiosity all play a meaningful part in determining the value of children.

  19. Formalization of Many-Valued Logics

    DEFF Research Database (Denmark)

    Villadsen, Jørgen; Schlichtkrull, Anders

    2017-01-01

    Partiality is a key challenge for computational approaches to artificial intelligence in general and natural language in particular. Various extensions of classical two-valued logic to many-valued logics have been investigated in order to meet this challenge. We use the proof assistant Isabelle...... to formalize the syntax and semantics of many-valued logics with determinate as well as indeterminate truth values. The formalization allows for a concise presentation and makes automated verification possible....

  20. Myths & Facts about Value-Added Analysis

    Science.gov (United States)

    TNTP, 2011

    2011-01-01

    This paper presents myths as well as facts about value-added analysis. These myths include: (1) "Value-added isn't fair to teachers who work in high-need schools, where students tend to lag far behind academically"; (2) "Value-added scores are too volatile from year-to-year to be trusted"; (3) "There's no research behind value-added"; (4) "Using…