Metal concentration in urban park soils of Sao Paulo 2. Buenos AiresPark

International Nuclear Information System (INIS)

Gumiero, Felipe C.; Figueiredo, Ana Maria G.; Camargo, Sonia P.; Pavese, Arthur; Sigolo, Joel B.

2007-01-01

As part of a project which aims metal concentration assessment in urban park soils of Sao Paulo, in the present paper the concentration of the elements As, Ba, Cr, Co, Cu, Pb, Sb and Zn were determined in surface soil samples (0-5 cm and 0-20 cm) from Buenos Aires park of Sao Paulo. This park is located in central region of the city, and is surrounded by avenues and streets, with different traffic volumes. Instrumental Neutron Activation Analysis (INAA) and X-ray Fluorescence (FRX) were used for metal analysis. Preliminary results showed concentration levels of the analyzed elements higher than the values considered as reference values for soils in Sao Paulo, according to the Environmental Protection Agency of the State of Sao Paulo (CETESB). These results suggest that these elements have anthropogenic origin and indicate a potential risk for soil quality. (author)

Metal assessment in urban park soils in Sao Paulo 1. Ibirapuera Park

International Nuclear Information System (INIS)

Figueiredo, Ana Maria G.; Camargo, Sonia P.; Pavese, Arthur C.; Gumiero, Felipe C.; Enzweiler, Jacinta; Sigolo, Joel B.

2007-01-01

In the last years urban soils received increasing attention by scientists, leading to studies focused on their description and investigation all over the world, due to the increasing metal pollution derived from incinerators, industrial waste, atmospheric deposition of dust and aerosols, and other activities. Metal contamination in Sao Paulo public parks is an important environmental question and there is little information on this subject. As part of a project which aims metal assessment in urban park soils from Sao Paulo, in the present paper the concentration of the elements As, Ba, Cr, Pb, Sb and Zn were determined in surface soil samples (0-5 cm) from Ibirapuera park of Sao Paulo. Ibirapuera park is one of the biggest and most visited parks of the city of Sao Paulo, receiving during the weekends more than 400,000 visitors. Instrumental Neutron Activation Analysis (INAA) and X-ray Fluorescence (FRX) were used for metal analysis. Preliminary results showed concentration levels of the analyzed elements higher than the values considered as reference values for soils in Sao Paulo, according to the Environmental Protection Agency of the State of Sao Paulo (CETESB). For As, Ba, Cr and Sb, in some samples the concentrations were even higher than the Prevention values reported by CETESB. The high concentrations of the elements As, Ba, Cr, Pb, Sb and Zn in the Ibirapuera park top soils suggest an anthropogenic source and indicate a potential damage to soil quality. (author)

The basic and ultrabasic dikes from the coast region between the Sao Sebastiao and Ubatuba cities, Sao Paulo State, SP, Brazil; Os diques basicos e ultrabasicos da regiao costeira entre as cidades de Sao Sebastiao e Ubatuba, estado de Sao Paulo, SP, Brasil

Energy Technology Data Exchange (ETDEWEB)

Garda, Gianna Maria

1995-12-31

The coastline between Sao Sebastiao and Ubatuba cities and the shores of Sao Sebastiao, Anchieta and Mar Virado islands (Sao Paulo State, Brazil) are crosscut by several small swarms and isolated dykes trending N55E. The main rock types range from basic to intermediate, but also a conspicuous variety of alkaline lamprophyres occur side by side with the main group. The thickness of the basic to intermediate dykes vary widely, from a few centimeters to several metres, while the lamprophyres are a few tens of centimeters thick. The objective of this thesis is the petrographic, mineralogic, petrochemical and isotopic characterization of the basic and ultrabasic dykes that occur between the Sao Sebastiao and Ubatuba cities (State of Sao Paulo), also including some occurrences from the Sao Sebastiao, Mar Virado and Anchieta islands and from the Bairro Alto region (Folha de Natividade da Serra). The petrogenetic model presented is based in the national and international bibliography. (author) 146 refs., 44 figs., 24 tabs.

The basic and ultrabasic dikes from the coast region between the Sao Sebastiao and Ubatuba cities, Sao Paulo State, SP, Brazil; Os diques basicos e ultrabasicos da regiao costeira entre as cidades de Sao Sebastiao e Ubatuba, estado de Sao Paulo, SP, Brasil

Energy Technology Data Exchange (ETDEWEB)

Garda, Gianna Maria

1996-12-31

The coastline between Sao Sebastiao and Ubatuba cities and the shores of Sao Sebastiao, Anchieta and Mar Virado islands (Sao Paulo State, Brazil) are crosscut by several small swarms and isolated dykes trending N55E. The main rock types range from basic to intermediate, but also a conspicuous variety of alkaline lamprophyres occur side by side with the main group. The thickness of the basic to intermediate dykes vary widely, from a few centimeters to several metres, while the lamprophyres are a few tens of centimeters thick. The objective of this thesis is the petrographic, mineralogic, petrochemical and isotopic characterization of the basic and ultrabasic dykes that occur between the Sao Sebastiao and Ubatuba cities (State of Sao Paulo), also including some occurrences from the Sao Sebastiao, Mar Virado and Anchieta islands and from the Bairro Alto region (Folha de Natividade da Serra). The petrogenetic model presented is based in the national and international bibliography. (author) 146 refs., 44 figs., 24 tabs.

Metal assessment in urban park soils in Sao Paulo 4. Alfredo Volpi (Morumbi Park)

International Nuclear Information System (INIS)

Camargo, Sonia P.; Figueiredo, Ana Maria G.; Pavese, Arthur C.; Gumiero, Felipe C.; Enzweiler, Jacinta

2007-01-01

The presence of elevated metal concentrations in soils of the urban environment has been recognized as an important source of metal intake to humans, particularly to children, which are more susceptible to the adverse effects of soil ingestion than adults. There has been little research on urban soils in Sao Paulo, a very populated city with severe pollution problems, and there is little information about metal concentration levels in public parks of Sao Paulo. As part of a project which aims metal assessment in urban park soils from Sao Paulo, in the present paper the concentration of the elements As, Ba, Cr, Sb and Zn were determined in topsoil samples (0- 5 cm and 0-20 cm) from Alfredo Volpi (Morumbi) park of Sao Paulo. Instrumental Neutron Activation Analysis (INAA) was used for metal analysis. Preliminary results showed higher concentrations of As, Ba and Sb compared with the values considered as reference for soils in Sao Paulo, according to Environmental Protection Agency of the State of Sao Paulo (CETESB). In some samples Ba showed concentration levels higher than the Prevention values reported by CETESB. (author)

Influence of SaOS-2 cells on corrosion behavior of cast Mg-2.0Zn0.98Mn magnesium alloy.

Science.gov (United States)

Witecka, Agnieszka; Yamamoto, Akiko; Święszkowski, Wojciech

2017-02-01

In this research, the effect of the presence of living cells (SaOS-2) on in vitro degradation of Mg-2.0Zn-0.98Mn (ZM21) magnesium alloy was examined by two methods simple immersion/cell culture tests and electrochemical measurements (electrochemical impedance spectroscopy and potentiodynamic polarization) under cell culture conditions. In immersion/cell culture tests, when SaOS-2 cells were cultured on ZM21 samples, pH of cell culture medium decreased, therefore weight loss and Mg 2+ ion release from the samples increased. Electrochemical measurements revealed the presence of living cells increased corrosion rate (I corr ) and decreased polarization resistance (R p ) after 48h of incubation. This acceleration of ZM21 corrosion can mainly be attributed to the decrease of medium pH due to cellular metabolic activities. Copyright © 2016 Elsevier B.V. All rights reserved.

Utilidad de la relación Sao2/Fio2 en la evaluación del grado de compromiso pulmonar en pacientes críticos

Directory of Open Access Journals (Sweden)

Alonso Gómez Duque

2002-01-01

Full Text Available Background: Arteriovenous admixture or intrapulmonary shunt and the relation between PaO2 and FI02 (PaO2/FiO2 have been advocated as the main indicators of pulmonary function. Because the Pa02 is a measure of the oxygen given to the tissues, as well as the Sa02, we could expect a close relationship between the Pa02IFI02 index and a new one, the SaO2/FiO2 index, Methods: We conducted a prospective study in a cohortofl07 patients with different pathologies in an Intensive Care Unit, collecting 507 samples of arterial and central venous gases and measuring the Sa02 by pulse oximeter at the same time. PaO2/FiO2 and Sa O2/FiO2, as well as intrapulmonary shunt using invasive and noninvasive methods, were caIculated. The Lung Injury Score (LIS and the Multiple Organ Dysfunction score were calculated too. Results: We found a good correlation between Sa O2/FiO2 and PaO2/FiO2. (R2=0,81,R=0.9, and between the intrapulmonary shuntfraction calculated with invasive and noninvasive methods.(R2=0.75, R=0.86. The data were correlationed with a simple linear regression analysis. Five groups of SaO2/FiO2 were found and a punctuation from Oto 4 was established for them, in a similar approach to the one used by Murray in the Lung Injury Score (LIS and Marshall in the Multiple Organ Dysfunction score. By using this punctuation, we replaced the PaO2/FiO2 by the SaO2/FiO2 in the scale and recalculated the LIS finding a good correlation between the score with PaO2/FiO2 and the one with SaO2/FiO2 (R2=0.94,R=0.96. The same was true for the correlation between the Marshall score with PaO2/FiO2 and the one with SaO2/FiO2. (R2=O.85, R=0.92. The correlation was mantained when a stratified analysis was made according to the degree of severity of the pulmonary injury. Conclusions: SaO2/FiO2 is an useful indicator of the oxygenation in a similar way as the PaO2/FiO2 índex, It could be incorporated into the LIS and Marshall score with similar results. The usefulness of the

Basic and ultrabasic coastal dykes adjacent to the Sao Sebastiao Channel (North coast of Sao Paulo State, Brazil)

International Nuclear Information System (INIS)

Garda, Gianna Maria; Schorscher, Johann Hans Daniel

1996-01-01

The portions of the Precambrian Costeiro Complex adjacent to the Sao Sebastiao Channel (Sao Paulo State, Brazil) are crosscut by mafic dykes of basic to intermediate composition, lamprophyres and trachytes. The former have been correlated with the basalts of the Parana Basin, while the lamprophyres are expressions of an alkaline magmatism different from the one that happened approximately 80 Ma ago in the Sao Sebastiao, Buzios, Vitoria and Montao de Trigo islands, where more acid terms predominate with associated trachytes and rare phonolites. The basic-ultrabasic lamprophyric magmatism is widespread along the Sao Paulo and Rio de Janeiro coasts; they are independent from and most likely older than the stocks and alkaline massifs. (author)

In vitro electromagnetically stimulated SAOS-2 osteoblasts inside porous hydroxyapatite

Science.gov (United States)

Fassina, Lorenzo; Saino, Enrica; Sbarra, Maria Sonia; Visai, Livia; De Angelis, Maria Gabriella Cusella; Magenes, Giovanni; Benazzo, Francesco

2009-01-01

One of the key challenges in reconstructive bone surgery is to provide living constructs that possess the ability to integrate in the surrounding tissue. Bone graft substitutes, such as autografts, allografts, xenografts, and biomaterials have been widely used to heal critical-size long bone defects due to trauma, tumor resection, congenital deformity, and tissue degeneration. In particular, porous hydroxyapatite is widely used in reconstructive bone surgery owing to its biocompatibility. In addition, the in vitro modification of hydroxyapatite with osteogenic signals enhances the tissue regeneration in vivo, suggesting that the biomaterial modification could play an important role in tissue engineering. In this study we have followed a biomimetic strategy where electromagnetically stimulated SAOS-2 human osteoblasts proliferated and built their extracellular matrix inside a porous hydroxyapatite scaffold. The electromagnetic stimulus had the following parameters: intensity of the magnetic field equal to 2 mT, amplitude of the induced electric tension equal to 5 mV, frequency of 75 Hz, and pulse duration of 1.3 ms. In comparison with control conditions, the electromagnetic stimulus increased the cell proliferation and the surface coating with bone proteins (decorin, osteocalcin, osteopontin, type-I collagen, and type-III collagen). The physical stimulus aimed at obtaining a better modification of the biomaterial internal surface in terms of cell colonization and coating with bone matrix. PMID:19827111

Effect of bioglass on growth and biomineralization of SaOS-2 cells in hydrogel after 3D cell bioprinting.

Directory of Open Access Journals (Sweden)

Xiaohong Wang

Full Text Available We investigated the effect of bioglass (bioactive glass on growth and mineralization of bone-related SaOS-2 cells, encapsulated into a printable and biodegradable alginate/gelatine hydrogel. The hydrogel was supplemented either with polyphosphate (polyP, administered as polyP • Ca2+-complex, or silica, or as biosilica that had been enzymatically prepared from ortho-silicate by silicatein. These hydrogels, together with SaOS-2 cells, were bioprinted to computer-designed scaffolds. The results revealed that bioglass (nanoparticles, with a size of 55 nm and a molar ratio of SiO2 : CaO : P2O5 of 55 : 40 : 5, did not affect the growth of the encapsulated cells. If silica, biosilica, or polyP • Ca2+-complex is co-added to the cell-containing alginate/gelatin hydrogel the growth behavior of the cells is not changed. Addition of 5 mg/ml of bioglass particles to this hydrogel significantly enhanced the potency of the entrapped SaOS-2 cells to mineralize. If compared with the extent of the cells to form mineral deposits in the absence of bioglass, the cells exposed to bioglass together with 100 µmoles/L polyP • Ca2+-complex increased their mineralization activity from 2.1- to 3.9-fold, or with 50 µmoles/L silica from 1.8- to 2.9-fold, or with 50 µmoles/L biosilica from 2.7- to 4.8-fold or with the two components together (100 µmoles/L polyP • Ca2+-complex and 50 µmoles/L biosilica from 4.1- to 6.8-fold. Element analysis by EDX spectrometry of the mineral nodules formed by SaOS-2 revealed an accumulation of O, P, Ca and C, indicating that the mineral deposits contain, besides Ca-phosphate also Ca-carbonate. The results show that bioglass added to alginate/gelatin hydrogel increases the proliferation and mineralization of bioprinted SaOS-2 cells. We conclude that the development of cell-containing scaffolds consisting of a bioprintable, solid and cell-compatible inner matrix surrounded by a printable hard and flexible outer matrix containing

Engineering a morphogenetically active hydrogel for bioprinting of bioartificial tissue derived from human osteoblast-like SaOS-2 cells.

Science.gov (United States)

Neufurth, Meik; Wang, Xiaohong; Schröder, Heinz C; Feng, Qingling; Diehl-Seifert, Bärbel; Ziebart, Thomas; Steffen, Renate; Wang, Shunfeng; Müller, Werner E G

2014-10-01

Sodium alginate hydrogel, stabilized with gelatin, is a suitable, biologically inert matrix that can be used for encapsulating and 3D bioprinting of bone-related SaOS-2 cells. However, the cells, embedded in this matrix, remain in a non-proliferating state. Here we show that addition of an overlay onto the bioprinted alginate/gelatine/SaOS-2 cell scaffold, consisting of agarose and the calcium salt of polyphosphate [polyP·Ca(2+)-complex], resulted in a marked increase in cell proliferation. In the presence of 100 μm polyP·Ca(2+)-complex, the cells proliferate with a generation time of approximately 47-55 h. In addition, the hardness of the alginate/gelatin hydrogel substantially increases in the presence of the polymer. The reduced Young's modulus for the alginate/gelatin hydrogel is approximately 13-14 kPa, and this value drops to approximately 0.5 kPa after incubation of the cell containing scaffolds for 5 d. In the presence of 100 μm polyP·Ca(2+)-complex, the reduced Young's modulus increases to about 22 kPa. The hardness of the polyP·Ca(2+)-complex containing hydrogel remains essentially constant if cells are absent in the matrix, but it drops to 3.2 kPa after a 5 d incubation period in the presence of SaOS-2 cells, indicating that polyP·Ca(2+)-complex becomes metabolized, degraded, by the cells. The alginate/gelatine-agarose system with polyP·Ca(2+)-complex cause a significant increase in the mineralization of the cells. SEM analyses revealed that the morphology of the mineral nodules formed on the surface of the cells embedded in the alginate/gelatin hydrogel do not significantly differ from the nodules on cells growing in monolayer cultures. The newly developed technique, using cells encapsulated into an alginate/gelatin hydrogel and a secondary layer containing the morphogenetically active, growth promoting polymer polyP·Ca(2+)-complex opens new possibilities for the application of 3D bioprinting in bone tissue engineering. Copyright �

Human subjects research handbook: Protecting human research subjects. Second edition

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-01-30

This handbook serves as a guide to understanding and implementing the Federal regulations and US DOE Orders established to protect human research subjects. Material in this handbook is directed towards new and continuing institutional review board (IRB) members, researchers, institutional administrators, DOE officials, and others who may be involved or interested in human subjects research. It offers comprehensive overview of the various requirements, procedures, and issues relating to human subject research today.

The basic and ultrabasic dikes from the coast region between the Sao Sebastiao and Ubatuba cities, Sao Paulo State, SP, Brazil

International Nuclear Information System (INIS)

Garda, Gianna Maria

1995-01-01

The coastline between Sao Sebastiao and Ubatuba cities and the shores of Sao Sebastiao, Anchieta and Mar Virado islands (Sao Paulo State, Brazil) are crosscut by several small swarms and isolated dykes trending N55E. The main rock types range from basic to intermediate, but also a conspicuous variety of alkaline lamprophyres occur side by side with the main group. The thickness of the basic to intermediate dykes vary widely, from a few centimeters to several metres, while the lamprophyres are a few tens of centimeters thick. The objective of this thesis is the petrographic, mineralogic, petrochemical and isotopic characterization of the basic and ultrabasic dykes that occur between the Sao Sebastiao and Ubatuba cities (State of Sao Paulo), also including some occurrences from the Sao Sebastiao, Mar Virado and Anchieta islands and from the Bairro Alto region (Folha de Natividade da Serra). The petrogenetic model presented is based in the national and international bibliography. (author)

Geochronological study of the metaconglomerates of the Sao Roque Group, Sao Paulo State

International Nuclear Information System (INIS)

Tassinari, C.C.G.; Kawashita, K.; Kikuchi, R.K.P. de

1985-01-01

This work deals with the geochronological study of the metaconglomerates of the Sao Roque Group by Rb-Sr whole rock measurements and K-Ar method in minerals concentrate. The granite-gneissic pebbles from the metaconglomerates have been analysed by Rb-Sr isochronic method and yelded an age of 1200+100 Ma. with a 87 Sr/ 86 Sr intercept of 0.737 +- 0.003. In our view this age might be associated to the metamorphic episode affecting the pre-existent granitic rocks before the epoch of the Sao Roque group sedimentation, or to the original age of the pebbles. The analytical points from the conglomerate matrix seem to define a linear array with 800Ma. This age, probably, represents the epoch of the main metamorphic event on the Sao Roque Group. The K-Ar micas determinations on rocks of the unit in study are concordant in ages, with values around 620.. These ages represent the tectonic estabilization epoch of the Pico de Jaragua region. (Author) [pt

Sao Luiz do Paraltinga underwater

International Nuclear Information System (INIS)

Auada, F.; Angueira, A.; Bakiewicz, G.; Cerqueira, D.; Maganini, E.; Morais, C.

2012-01-01

Sao Luiz do Paaitinga, a city of Sao Paulo, Brazil, is considered a cultural and historical heritage of the country. On January first, of 2010 the city was hit by a devasting flood which resulted in the loss and destruction of historical and public buildings, monuments and houses. The referred places suffered damage in their structure and loss of physical and electronic documents. Most of the population lost its legal identity. The nucleo de Conservacao do Arquivo Publico do Estado de Sao Paulo - Nucleus for Conservation of public files of Sao Paulo- APESP and the Nucleo de Conservacao e Restauro Edson Motta, laboratory from National Service for Industrial Apprenticeship, became associated in order to save the documents. the access to the documents was only autorized 26 days after the flooding due to bureaucratic reasons. With few economic ressources and no time to come up with a big plan but only necessary practical courses of action, a completely manual method was established to recover this documents, with the exception of the third allotment. It had to be submitted to gamma-rays cobalt-60 from a multi purpose compact type irradiator from the Centro de Tecnologia das radiacoes do Instituto de Pesquisas Energeticas e Nucleares due to enormous fungus infection. Describing the methodology applied to recover all documents and comparing the third allotment with the others which did not receive irradiation, are the purpose of this paper.

subjective approach to subjective approach to human physiological

African Journals Online (AJOL)

eobe

the only physiological variables that influence the heat balance [4]. Yao et al [2] .... between the human responses and outdoor climate. 4.1 Subjective Response ... months seem to be influenced by cloud cover rather than the altitude.

Distribution and origin of hydrocarbons in water and sediment in Sao Sebastiao, SP, Brazil

International Nuclear Information System (INIS)

Zanardi, Eliete; Bicego, Marcia Caruso; Miranda, Luiz Bruner de; Weber, Rolf Roland

1999-01-01

This study describes the dissolved/dispersed petroleum hydrocarbons (DDPH) in surface water and the origin and distribution of aliphatic and aromatic hydrocarbons in samples from the surface bottom sediments. The main objective was to verify the anthropogenic contribution on the adjacent inner shelf of Sao Sebastiao, taking into account the distribution of hydrographic properties and knowledge of the main circulation. The DDPH concentration range of the 20 samples were from 0.35 to 2.50 m u g . L -1 , characterising this region as slightly affected by the contribution of petroleum hydrocarbons. Considering sediment hydrocarbon results, sites located in the inner shelf were divided into three groups: one with mainly biogenic hydrocarbons, a second one with biogenic and petroleum hydrocarbons and a third with significant contribution of petroleum hydrocarbons. These results show an influence of human activities in the Sao Sebastiao Channel on the surrounding areas of the inner shelf. (Author)

Environmental radiation monitoring in Sao Paulo state

International Nuclear Information System (INIS)

Agudo, E.G.; Albuquerque, A.M. de; Vasconcellos, N.V. de

1991-01-01

The results of environmental radiation monitoring that CETESB (Technological Company of Environmental Sanitation of Sao Paulo) does in influence areas of radioactive materials store of Nuclemon Minero-Quimica S.A. in the municipality of Itu, Sao Paulo State, are presented. The data comprises the period of 1983-1990 with information about concentration levels of radium-225 in underground and superficial waters of the region. On March, 1989, was detected contamination in a well near of the stores. The levels observed, its implications in terms of health risks and possible causes of event are discussed too. The goals that CETESB intends to reach in terms of monitoring of environmental radiation in Sao Paulo State are also presented. (C.M.)

Energy balance of the Sao Paulo State - 1990

International Nuclear Information System (INIS)

1992-01-01

This document informs the energetic balance for Sao Paulo State - 1990, with information referring to the year 1989, containing the energy fluxes from primary and secondary energy sources in the main sectors of Sao Paulo economy. 32 figs., 99 tabs

Sao Paulo jätkab biennaali / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2001-01-01

Sao Paulo biennaal sai 50aastaseks. Kuni 29. VII toimunud juubelinäitusest. 2002. a. leiab aset XXV Sao Paulo biennaal "Metropoliikonograafiad", kus esinevad kunstnikud kaheksast maailma suurlinnast.

Sao Paulo pelletron accelerator: fortieth anniversary

International Nuclear Information System (INIS)

Pereira, Dirceu

2012-01-01

Full text: This year the 8MV Sao Paulo Pelletron tandem accelerator completes 40 years . This electrostatic accelerator was installed in the Sao Paulo University in 1972 , and it was the first of this model constructed the National Electrostatic Corporation with several innovations particularly with respect to the new concept of accelerator tube and the charge system. In the talk will be discussed the performance of the accelerator during all these years and the main result scientific results. (author)

Sao Paulo pelletron accelerator: fortieth anniversary

Energy Technology Data Exchange (ETDEWEB)

Pereira, Dirceu [Universidade de Sao Paulo (IF/USP), SP (Brazil). Inst. de Fisica

2012-07-01

Full text: This year the 8MV Sao Paulo Pelletron tandem accelerator completes 40 years . This electrostatic accelerator was installed in the Sao Paulo University in 1972 , and it was the first of this model constructed the National Electrostatic Corporation with several innovations particularly with respect to the new concept of accelerator tube and the charge system. In the talk will be discussed the performance of the accelerator during all these years and the main result scientific results. (author)

Metal assessment in urban park soils in Sao Paulo. 3. Aclimacao Park

International Nuclear Information System (INIS)

Pavese, Arthur C.; Figueiredo, Ana Maria G.; Camargo, Sonia P.; Gumiero, Felipe C.; Enzweiler, Jacinta

2007-01-01

As part of a project which aims metal assessment in urban park soils from Sao Paulo, in the present paper the concentration of the elements As, Ba, Zn, Sb, Se, Co, Cr, Cu and Pb were determined in surface soil samples (0-5 cm and 0-20 cm) from Aclimacao park of Sao Paulo. Urban soils play an important role in maintaining the environmental quality as they can act as both source and sink for pollutants that can affect human health. Parks and playgrounds are where urban children spend most of their time outdoors and are also where children most frequently come in contact with soil. Aclimacao park is located at the central region of the city, in a residential area. Instrumental Neutron Activation Analysis (INAA) and X-Ray Fluorescence (XRF) were used for metal analysis. The results obtained for Zn were higher than the values considered as reference values for soils in Sao Paulo, according to the Environmental Protection Agency of the State of Sao Paulo (CETESB), but lower than the Prevention values. For Ba, Cr, and Sb, the results obtained showed concentration levels higher than Prevention value reported by CETESB. According to CETESB, metal concentration levels above the Prevention value can cause prejudicial alterations in soil and subterranean water quality. For As, in the 0-5 cm samples, the concentration levels were near or above the Intervention value for agricultural area reported by CETESB. (author)

Distribution and origin of hydrocarbons in water and sediment in Sao Sebastiao, SP, Brazil

Energy Technology Data Exchange (ETDEWEB)

Zanardi, Eliete [Universidade de Sao Paulo, Instituto Oceanografico, Sao Paulo, SP (Brazil); Bicego, Marcia Caruso; Miranda, Luiz Bruner de; Weber, Rolf Roland [Miami Univ., RSMAS/NAC, Miami, FL (United States)

1999-04-01

This study describes the dissolved/dispersed petroleum hydrocarbons (DDPH) in surface water and the origin and distribution of aliphatic and aromatic hydrocarbons in samples from the surface bottom sediments. The main objective was to verify the anthropogenic contribution on the adjacent inner shelf of Sao Sebastiao, taking into account the distribution of hydrographic properties and knowledge of the main circulation. The DDPH concentration range of the 20 samples were from 0.35 to 2.50 {sup m}u{sup g}. L{sup -1}, characterising this region as slightly affected by the contribution of petroleum hydrocarbons. Considering sediment hydrocarbon results, sites located in the inner shelf were divided into three groups: one with mainly biogenic hydrocarbons, a second one with biogenic and petroleum hydrocarbons and a third with significant contribution of petroleum hydrocarbons. These results show an influence of human activities in the Sao Sebastiao Channel on the surrounding areas of the inner shelf. (Author)

Energy balance of the Sao Paulo State - 1995

International Nuclear Information System (INIS)

1996-01-01

This work informs the energetic balance of Sao Paulo State - 1995, with information referring to the year 1994, containing the energy fluxes from primary and secondary energy sources in the main sectors of Sao Paulo economy. An electronic version for windows environment is also available. 81 figs., 179 tabs

42 CFR 86.33 - Human subjects; animal welfare.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Human subjects; animal welfare. 86.33 Section 86.33... Occupational Safety and Health Direct Traineeships § 86.33 Human subjects; animal welfare. Where the...) Chapter 1-43 of the Department Grants Administration Manual 2 068 concerning animal welfare. 2 See...

An advanced automation system for operation of Sao Paulo pumping stations from TRANSPETRO Master Control Center - CNCO

Energy Technology Data Exchange (ETDEWEB)

Corcioli, Mario Sergio; Barreto, Camila Maria Benevenuto [TRANSPETRO, Rio de Janeiro, RJ (Brazil)

2009-07-01

Since 2000 the operations of the TRANSPETRO pumping stations in the state of Sao Paulo region began to be transferred from local control centers located at the transfer and storage terminals to the National Operational Control Center (CNCO) of TRANSPETRO, located at the headquarters of the company, in Rio de Janeiro. The proposed paper aims to presenting an overview of the automation system that was developed to enable such pumping stations to be operated from CNCO in a reliable and secure manner, focusing on tools that offer an embedded system alarms completely free of false alarms with automatic determining of the root cause, and also automatic and advanced diagnoses of problems caused by failures of hardware, human error and abnormal conditions of the process, providing the CNCO SCADA system of accurate and quality information that help operators to make decisions. The referred automation system was integrated for the first time to CNCO SCADA system in 2000, for pipeline pumps of Osvat (Sao Sebastiao - Vale do Paraiba pipeline) station at the Sao Sebastiao Terminal - northern coast of Sao Paulo region. (author)

Ambient radiation dose to the population of the city of Sao Paulo-Brazil: indoor gamma distribution

International Nuclear Information System (INIS)

Otsubo, Sergio M.; Yoshimura, Elizabeth M.

2001-01-01

The objective of this work is to present results of indoor ambient dose equivalent rate (H * (10)) in the city of Sao Paulo. Studies show that people of industrialized cities spend indoor approximately 80% of their time, and that there are great variations of the rate of H * (10) all over the world. Values of environmental radiation are important base to epidemiological studies, or analyses of consequences and effects of radioactive or nuclear accidents and also to assist research on biological effects of low doses, a very controversial subject in the literature. There are no reports in the literature about environmental radiation in the city of Sao Paulo, showing the important of this study. Environmental radiation exists everywhere in the planet, so the human beings are exposed to it at any time or place, being indoor or outdoor. Three types of commercial indoor ambient with large flow of the population were analyzed: bank offices, shops in the neighborhood of the banks, and shopping centers. A gamma ray portable spectrometer was used, composed by a crystal of NaI (Tl). The mean value of the H * (10) rate obtained was 173,8(17) nSv/h. The results analyzed by commerce type and by the health divisions of the city are also presented. (author)

Gamma ionization of Phagicola longa (Trematoda:Heterophyidae) in Mugilidae (pisces) in Sao Paulo, Brazil

Energy Technology Data Exchange (ETDEWEB)

Antunes, S.A.; Wiendl, F.M.; Almeida Dias, E.R.; Arthur, V.; Daniotti, C. (Sao Paulo Univ., SP (Brazil))

The mullet (Mugilidae) is a fish caught in large quantities in brackish and marine waters of the southern Brazilian coast, which in consequence of its raw consumption as ''sashimi'', a typical Japanese dish, has led to ten cases of human infection by Phagicola longa in Sao Paulo, Brazil. The mullet acts as a second intermediate host for the parasite, as in human heterophyiasis in the Near and Far East. In order to control these infections under commercial storage conditions and in raw consumption, the radiolysis of P. longa was studied in three mullet species - the silver mullet (Mugil curema), the grey mullet (M. platanus) and the ''paratipema'' (Mugil sp.) -subjected to ionization ranging from 1.0 to 10.0 kGy (2.21 kGy/h). It was observed that 1.0 and 2.0 kGy caused a motility decrease in silver mullet parasites from 100% to 15% and 17%, and that doses of 4.0 and 10.0 kGy caused metacercaria inviability. The parasite motility decreased in the grey mullet treated with doses of 2.0, 2.5, 3.0 and 3.5 kGy, from 56% to 31%, 9%, 18% and 5%, respectively, 4.0 kGy tending to be the control dose for P. Longa. This dose also controls other metacercaria found in the ''parati-pema'', without changing the odor, color or appearance of the treated mullet. (author).

Gamma ionization of Phagicola longa (Trematoda:Heterophyidae) in Mugilidae (pisces) in Sao Paulo, Brazil

International Nuclear Information System (INIS)

Antunes, S.A.; Wiendl, F.M.; Almeida Dias, E.R.; Arthur, V.; Daniotti, C.

1993-01-01

The mullet (Mugilidae) is a fish caught in large quantities in brackish and marine waters of the southern Brazilian coast, which in consequence of its raw consumption as ''sashimi'', a typical Japanese dish, has led to ten cases of human infection by Phagicola longa in Sao Paulo, Brazil. The mullet acts as a second intermediate host for the parasite, as in human heterophyiasis in the Near and Far East. In order to control these infections under commercial storage conditions and in raw consumption, the radiolysis of P. longa was studied in three mullet species - the silver mullet (Mugil curema), the grey mullet (M. platanus) and the ''paratipema'' (Mugil sp.) -subjected to ionization ranging from 1.0 to 10.0 kGy (2.21 kGy/h). It was observed that 1.0 and 2.0 kGy caused a motility decrease in silver mullet parasites from 100% to 15% and 17%, and that doses of 4.0 and 10.0 kGy caused metacercaria inviability. The parasite motility decreased in the grey mullet treated with doses of 2.0, 2.5, 3.0 and 3.5 kGy, from 56% to 31%, 9%, 18% and 5%, respectively, 4.0 kGy tending to be the control dose for P. Longa. This dose also controls other metacercaria found in the ''parati-pema'', without changing the odor, color or appearance of the treated mullet. (author)

Metal and trace element sediment assessment from two estuarine systems: Santos/Sao Vicente and Cananeia, State of Sao Paulo, Brazil

International Nuclear Information System (INIS)

Amorim, Eduardo Paulo de

2012-01-01

This study evaluated some toxic metals such as Cd, Hg and Pb and some other major and trace elements in surface sediment samples, from two different systems under different degrees of anthropogenic actions: the estuarine system of Santos/Sao Vicente and the southern part of the Cananeia estuary, both on the Sao Paulo state coast. Sediment samples were collected in 16 stations in the Santos/Sao Vicente estuary and 13 stations in the Cananeia estuary, during summer and winter of 2005 and 2006, in both estuaries. Three analytical techniques were used: NAA, AAS and ICP OES. NAA was used for the quantification of major element concentration levels (Ca, Fe and Na), trace elements (As, Ba, Br, Cd, Co, Cu, Cr, Cs, Hf, Rb, Sb, Sc, Se, Ta, Th, U, and Zn and rare earths elements La, Ce, Eu, Nd, Sm, Lu, Tb, Yb). ICP OES was used for determination of the concentration levels of Al, Ba, Be, Bi, B, Cd, Co, Pb, Cu, Cr, Sn, Sr, Fe, Li, Mn, Mo, Ni, Tl, Ti, V and Zn. AAS for Cd and Pb quantification through graphite furnace (GF AAS) and Hg through cold vapor generation (CV AAS). Methodology validation according to precision and accuracy was performed by reference material analyses for the three analytical techniques used. Detection and quantification limits were calculated for each element evaluated. Seasonal variations (summer and winter), spatial and temporal (2005 e 2006) variations of metals and trace elements were also evaluated. In the Santos estuary, in general, metal and trace element concentrations , organic matter content and % of pelitic fraction found in the Santos channel (area 1) were higher than those of the Santos Bay (area 2) and Sao Vicente channel (area 3). Area 1 suffers high impact from industrial activities from the Cubatao region and Santos port. The sediments from station 14 (area 3, Sao Vicente channel), showed the same behavior of those from area 1, suffering influence from the industrial pole and located in a mangrove area. In comparison with TEL and PEL

The Monitoring Of Thunderstorm In Sao Paulo's Urban Areas, Brazil

Science.gov (United States)

Gin, R. B.; Pereira, A.; Beneti, C.; Jusevicius, M.; Kawano, M.; Bianchi, R.; Bellodi, M.

2005-12-01

A monitoring of thunderstorm in urban areas occurred in the vicinity of Sao Bernardo do Campo, Sao Paulo from November 2004 to March 2005. Eight thunderstorms were monitored by local electric field, video camera, Brazilian Lightning Location Network (RINDAT) and weather radar. The most of these thunderstorms were associated with the local convection and cold front. Some of these events presented floods in the vicinity of Sao Bernardo and in the Metropolitan Area of Sao Paulo (MASP) being associated with local sea breeze circulation and the heat island effect. The convectives cells exceeding 100km x 100 km of area, actives between 2 and 3 hours. The local electric field identified the electrification stage of thunderstorms, high transients of lightning and total lightning rate of above 10 flashes per minute. About 29.5 thousands of cloud-to-ground lightning flashes were analyzed . From the total set of CG flashes analyzed, about 94 percent were negative strokes and presented average peak current of above 25kA, common for this region. Some lightning images were obtained by video camera and compared with transients of lightning and lightning detection network data. The most of these transients of lightning presented continuing current duration between 100ms and 200ms. A CG lightning occurred on 25th February was visually observed 3.5km from FEI campus, Sao Bernardo do Campo. This lightning presented negative polarity and estimed peak current of above 30kA. A spider was visually observed over FEI Campus at 17th March. No transients of lightning and recording by lightning location network were found.

Metals in soils adjacent to avenues of highly dense traffic of Sao Paulo city, Brazil

International Nuclear Information System (INIS)

Ticianelli, Regina B.; Ribeiro, Andreza P.; Figueiredo, Ana M.G.; Nammoura-Neto, Georges M.; Silva, Nathalia C.

2009-01-01

Sao Paulo is the largest city in Brazil with about 19 millions of inhabitants in the metropolitan area, more than 8 million motor vehicles and strong industrial activity at the metropolitan region, which are responsible for increasing pollution in the region. Nevertheless, there is little information on metal contents in the metropolitan region soils, which would be very useful as a fingerprint of the environmental pollution. The present study aimed to determine As, Ba, Co, Cr, Sb and Zn concentrations in soils adjacent to avenues of highly dense traffic downtown Sao Paulo city: Consolacao/Reboucas Avenues; 23 de Maio Avenue and Tiradentes Avenue, to assess their possible sources and potential environmental impact. The analytical technique employed was Instrumental Neutron Activation Analysis (INAA). The results show metal concentration levels higher than the values reference values for soils of Sao Paulo, according to the Environmental Protection Agency of the State Sao Paulo (CETESB) guidelines. As, Ba and Zn showed concentration levels above the Intervention Values in some points, indicating direct or indirect potential risks to human health. The traffic related element Ba, Sb and Zn presented concentrations above the Prevention Values in points with high density traffic and may be associated to vehicular emissions. (author)

Salmonella enterica serovar Choleraesuis vector delivering SaoA antigen confers protection against Streptococcus suis serotypes 2 and 7 in mice and pigs.

Science.gov (United States)

Li, Yu-An; Ji, Zhenying; Wang, Xiaobo; Wang, Shifeng; Shi, Huoying

2017-12-21

Streptococcus suis is one of the major pathogens that cause economic losses in the swine industry worldwide. However, current bacterins only provide limited prophylactic protection in the field. An ideal vaccine against S. suis should protect pigs against the clinical diseases caused by multiple serotypes, or at least protect against the dominant serotype in a given geographic region. A new recombinant Salmonella enterica serotype Choleraesuis vaccine vector, rSC0011, that is based on the regulated delayed attenuation system and regulated delayed antigen synthesis system, was developed recently. In this study, an improved recombinant attenuated Salmonella Choleraesuis vector, rSC0016, was developed by incorporating a sopB mutation to ensure adequate safety and maximal immunogenicity. In the spleens of mice, rSC0016 colonized less than rSC0011. rSC0016 and rSC0011 colonized similarly in Peyer's patches of mice. The recombinant vaccine rSC0016(pS-SaoA) induced stronger cellular, humoral, and mucosal immune responses in mice and swine against SaoA, a conserved surface protein that is present in many S. suis serotypes, than did rSC0011(pS-SaoA) without sopB or rSC0018(pS-SaoA), which is an avirulent, chemically attenuated vaccine strain. rSC0016(pS-SaoA) provided 100% protection against S. suis serotype 2 in mice and pigs, and full cross-protection against SS7 in pigs. This new vaccine vector provides a foundation for the development of a universal vaccine against multiple serotypes of S. suis in pigs.

Energy matrix of Sao Paulo state from 2006 to 2016; Matriz energetica do Estado de Sao Paulo 2006 a 2016

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-07-01

This report presents the economic and social energy scenarios in the state of Sao Paulo, Brazil; the analysis and projection of the energy consumption in the state concerning to industrial, residential, farming and cattle-raising, transportation, commercial, energy and public sectors. Analysis of the energy production in the state of Sao Paulo, Brazil, the production projection, the supply and consumption balance of energy is also presented.

Human subjects and experimental irradiation

International Nuclear Information System (INIS)

Rosen, R.

1985-01-01

In recent years the public has expressed concern about the use of human subjects in scientific research. Some professional institutions have adopted codes of practice to guide them in this matter. At the University of New South Wales, where human subjects are used in teaching and research programmes, a committee ensures that high ethical standards are maintained. As the volunteer subjects do not gain any benefit themselves from the procedures, their level of risk is kept low. One type of procedure in which risk is becoming quantifiable, is the irradiation of human subjects. To assist peer review groups, the ICRP, WHO and the National Health and Medical Research Council have enunciated principles which should be followed in the irradiation of human volunteer subjects. In general the role of the Committee is advisory to protect the rights of the investigator, the subject, and the institution. Some of the inherent problems are discussed

Metal and trace element sediment assessment from two estuarine systems: Santos/Sao Vicente and Cananeia, State of Sao Paulo, Brazil; Avaliacao da concentracao de metais e outros elementos de interesse em amostras de sedimentos dos estuarios de Santos/Sao Vicente e Cananeia, estado de Sao Paulo, Brasil

Energy Technology Data Exchange (ETDEWEB)

Amorim, Eduardo Paulo de

2012-07-01

This study evaluated some toxic metals such as Cd, Hg and Pb and some other major and trace elements in surface sediment samples, from two different systems under different degrees of anthropogenic actions: the estuarine system of Santos/Sao Vicente and the southern part of the Cananeia estuary, both on the Sao Paulo state coast. Sediment samples were collected in 16 stations in the Santos/Sao Vicente estuary and 13 stations in the Cananeia estuary, during summer and winter of 2005 and 2006, in both estuaries. Three analytical techniques were used: NAA, AAS and ICP OES. NAA was used for the quantification of major element concentration levels (Ca, Fe and Na), trace elements (As, Ba, Br, Cd, Co, Cu, Cr, Cs, Hf, Rb, Sb, Sc, Se, Ta, Th, U, and Zn and rare earths elements La, Ce, Eu, Nd, Sm, Lu, Tb, Yb). ICP OES was used for determination of the concentration levels of Al, Ba, Be, Bi, B, Cd, Co, Pb, Cu, Cr, Sn, Sr, Fe, Li, Mn, Mo, Ni, Tl, Ti, V and Zn. AAS for Cd and Pb quantification through graphite furnace (GF AAS) and Hg through cold vapor generation (CV AAS). Methodology validation according to precision and accuracy was performed by reference material analyses for the three analytical techniques used. Detection and quantification limits were calculated for each element evaluated. Seasonal variations (summer and winter), spatial and temporal (2005 e 2006) variations of metals and trace elements were also evaluated. In the Santos estuary, in general, metal and trace element concentrations , organic matter content and % of pelitic fraction found in the Santos channel (area 1) were higher than those of the Santos Bay (area 2) and Sao Vicente channel (area 3). Area 1 suffers high impact from industrial activities from the Cubatao region and Santos port. The sediments from station 14 (area 3, Sao Vicente channel), showed the same behavior of those from area 1, suffering influence from the industrial pole and located in a mangrove area. In comparison with TEL and PEL

Anthropic contribution on pollution in hydroelectric reservoirs: the case of Sao Simao's hydroelectric power plant - GO/MG, Brazil; Contribuicao antropica na poluicao de reservatorios hidreletricos: o caso da Usina Hidreletrica de Sao Simao - GO/MG

Energy Technology Data Exchange (ETDEWEB)

Fonseca, Gizele Araujo Borba da

2010-02-15

This study aimed to evaluate the contribution of anthropogenic pollution in hydroelectric reservoirs through a case study of the Sao Simao Hydropower. The literature relates the problem of eutrophication with the addition of nutrients (nitrogen and phosphorus) in excess, resulting in water pollution. Through data for both tributary rivers and the reservoir, it was found that the Sao Simao dam presents a framework for eutrophication. We made an analysis to see which tributary rivers were the main sources of nutrients released into the waters of the reservoir and a survey of possible human activities that are contributing to the intake of nutrients in these tributaries. (author)

Stratigraphical analysis of the neoproterozoic sedimentary sequences of the Sao Francisco Basin

International Nuclear Information System (INIS)

Martins, Mariela; Lemos, Valesca Brasil

2007-01-01

A stratigraphic analysis was performed under the principles of Sequence Stratigraphy on the neoproterozoic sedimentary sequences of the Sao Francisco Basin (Central Brazil). Three periods of deposition separated by unconformities were recognized in the Sao Francisco Megasequence: (1) Sequences 1 and 2, a cryogenian glaciogenic sequence, followed by a distal scarp carbonate ramp, developed during stable conditions, (2) Sequence 3, a Upper Cryogenian stack homoclinal ramps with mixed carbonate-siliciclastic sedimentation, deposited under a progressive influence of compressional stresses of the Brasiliano Cycle, (3) Sequence 4, a Lower Ediacaran shallow platform dominated by siliciclastic sedimentation of molassic nature, the erosion product of the nearby uplifted thrust sheets. Each of the carbonate-bearing sequences presents a distinct δ 13 C isotopic signature. The superposition to the global curve for carbon isotopic variation allowed the recognition of a major depositional hiatus between the Paranoa and Sao Francisco Megasequences, and suggested that the glacial diamictite deposition (Jequitai Formation) took place most probably around 800 Ma. This constrains the Sao Francisco Megasequence deposition to the interval between 800 and 600 Ma (the known ages of the Brasiliano Orogeny defines the upper limit). A minor depositional hiatus (700.680 Ma) was also identified separating sequences 2 and 3. Isotopic analyses suggest that from then on, more restricted environmental conditions were established in the basin, probably associated with a first order global event, which prevailed throughout deposition of the Sequence 3. (author)

42 CFR 86.19 - Human subjects; animal welfare.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Human subjects; animal welfare. 86.19 Section 86.19... Occupational Safety and Health Training Grants § 86.19 Human subjects; animal welfare. No grant award may be... concerning animal welfare. 2 The Department Grants Administration Manual is available for inspection at the...

Electron spin resonance dating of human teeth from Toca da Santa shelter of Sao Raimundo Nonato, Piaui, Brazil

Energy Technology Data Exchange (ETDEWEB)

Kinoshita, A. [Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Av. Bandeirantes, 3900, 14040-901 Ribeirao Preto, SP (Brazil); Universidade do Sagrado Coracao, Rua Irma Arminda 10-50, 17011-160 Bauru, SP (Brazil); Figueiredo, A.M.G. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Av. Lineu Prestes, 2242, Cidade Universitaria, 5422-970 Sao Paulo, SP (Brazil); Felice, G.D. [Fundacao Museu do Homem Americano-FUNDHAM, Rua Abdias Neves, no. 551, Centro, 64770-000 Sao Raimundo Nonato, Piaui (Brazil); Lage, M.C.S.M. [Universidade Federal do Piaui, Departamento de Quimica, Campus da Ininga, Ininga, 64049-550 Teresina, Piaui (Brazil); Guidon, N. [Fundacao Museu do Homem Americano-FUNDHAM, Rua Abdias Neves, no. 551, Centro, 64770-000 Sao Raimundo Nonato, Piaui (Brazil); Baffa, O. [Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Av. Bandeirantes, 3900, 14040-901 Ribeirao Preto, SP (Brazil)], E-mail: baffa@usp.br

2008-02-15

Results of the dating of fossil human teeth excavated from a shelter in the surroundings areas of the Serra da Capivara National Park, Sao Raimundo Nonato, Piaui, Brazil are presented. This shelter was partially excavated to search for more data that could improve the archaeological context of the Garrincho's limestone hill sites, where the Toca do Gordo do Garrincho shelter provided two human teeth dated by conventional C-14 in (12,170 {+-} 40) yBP (years before present) and calibrated age (2 Sigma, 95% probability) 15,245-14,690 yBP (Beta 136204) [E. Peyre, C. Guerin, N. Guidon, I. Coppens, CR Acad. Sci. Paris, Sciences de la terre et des planetes/ Earth and Planetary Sciences 327 (1998) 335, ]. This region is challenging the classical theories about the peopling of America. In agreement with such theories the first human groups would have arrived in America, through Behring, only about 20,000 years ago. The site Toca do Boqueirao da Pedra Furada is a rock-shelter situated at the cliff that is the frontier between the Pre-Cambrian Sao Francisco plain and the Devonian-Permian highlands of the Maranhao-Piaui basin. It was excavated from 1978 till 1988 and presented a very consistent stratigraphy, with thousand of lithic implements and hearths [F. Parenti, Le gisement quaternaire de la Pedra Furada (Piaui, Bresil), Stratigraphie, chronologie, evolution culturelle, Editions Recherches sur les civilisations, Paris, 2002, ; F. Parenti, Le Gisement Quaternaire de la Toca do Boqueirao da Pedra Furada (Piaui, Bresil) dans le Contexte de la Prehistoire Americaine Fouilles, Stratigraphie, Chronologie, Evolution Culturelle, Ph.D. diss, Ecole des Hautes Etudes en Sciences Sociales, Paris, 1993, 411p, ; F. Parenti, M. Fontugne, N. Guidon, C. Guerin, M. Faure, Chronostratigraphie des gisements archeologiques et paleontologiques de Sao Raimundo Nonato (Piaui, Bresil): contribution a la connaissance du peuplement pleistocene de l'Amerique, Supplement de la Revue d

Electron spin resonance dating of human teeth from Toca da Santa shelter of Sao Raimundo Nonato, Piaui, Brazil

International Nuclear Information System (INIS)

Kinoshita, A.; Figueiredo, A.M.G.; Felice, G.D.; Lage, M.C.S.M.; Guidon, N.; Baffa, O.

2008-01-01

Results of the dating of fossil human teeth excavated from a shelter in the surroundings areas of the Serra da Capivara National Park, Sao Raimundo Nonato, Piaui, Brazil are presented. This shelter was partially excavated to search for more data that could improve the archaeological context of the Garrincho's limestone hill sites, where the Toca do Gordo do Garrincho shelter provided two human teeth dated by conventional C-14 in (12,170 ± 40) yBP (years before present) and calibrated age (2 Sigma, 95% probability) 15,245-14,690 yBP (Beta 136204) [E. Peyre, C. Guerin, N. Guidon, I. Coppens, CR Acad. Sci. Paris, Sciences de la terre et des planetes/ Earth and Planetary Sciences 327 (1998) 335, ]. This region is challenging the classical theories about the peopling of America. In agreement with such theories the first human groups would have arrived in America, through Behring, only about 20,000 years ago. The site Toca do Boqueirao da Pedra Furada is a rock-shelter situated at the cliff that is the frontier between the Pre-Cambrian Sao Francisco plain and the Devonian-Permian highlands of the Maranhao-Piaui basin. It was excavated from 1978 till 1988 and presented a very consistent stratigraphy, with thousand of lithic implements and hearths [F. Parenti, Le gisement quaternaire de la Pedra Furada (Piaui, Bresil), Stratigraphie, chronologie, evolution culturelle, Editions Recherches sur les civilisations, Paris, 2002, ; F. Parenti, Le Gisement Quaternaire de la Toca do Boqueirao da Pedra Furada (Piaui, Bresil) dans le Contexte de la Prehistoire Americaine Fouilles, Stratigraphie, Chronologie, Evolution Culturelle, Ph.D. diss, Ecole des Hautes Etudes en Sciences Sociales, Paris, 1993, 411p, ; F. Parenti, M. Fontugne, N. Guidon, C. Guerin, M. Faure, Chronostratigraphie des gisements archeologiques et paleontologiques de Sao Raimundo Nonato (Piaui, Bresil): contribution a la connaissance du peuplement pleistocene de l'Amerique, Supplement de la Revue d

Anthropic contribution on pollution in hydroelectric reservoirs: the case of Sao Simao's hydroelectric power plant - GO/MG, Brazil; Contribuicao antropica na poluicao de reservatorios hidreletricos: o caso da Usina Hidreletrica de Sao Simao - GO/MG

Energy Technology Data Exchange (ETDEWEB)

Fonseca, Gizele Araujo Borba da

2010-02-15

This study aimed to evaluate the contribution of anthropogenic pollution in hydroelectric reservoirs through a case study of the Sao Simao Hydropower. The literature relates the problem of eutrophication with the addition of nutrients (nitrogen and phosphorus) in excess, resulting in water pollution. Through data for both tributary rivers and the reservoir, it was found that the Sao Simao dam presents a framework for eutrophication. We made an analysis to see which tributary rivers were the main sources of nutrients released into the waters of the reservoir and a survey of possible human activities that are contributing to the intake of nutrients in these tributaries. (author)

Energy statistical yearbook by municipalities of Sao Paulo state - 2015: calendar year 2014; Anuario estatistico de energeticos por municipio no estado de Sao Paulo - 2015: ano base 2014

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-07-01

The Government of the Sao Paulo state, Brazil, presents the {sup S}tatistical Yearbook of Energy by Municipality in the State of Sao Paulo in 2015 {sup -} calendar year 2014, prepared by Power State Department. The report provides consolidated data on the primary energy consumed by 645 municipalities - electricity, ethanol, petroleum products and natural gas, as well as their carbon dioxide (CO{sub 2}). It is about the production of strategic information to the municipalities together with the State Government to plan its priorities in energy and services.

The RID2 biofidelic rear impact dummy: a pilot study using human subjects in low speed rear impact full scale crash tests.

Science.gov (United States)

Croft, Arthur C; Philippens, Mathieu M G M

2007-03-01

Human subjects and the recently developed RID2 rear impact crash test dummy were exposed to a series of full scale, vehicle-to-vehicle crash tests. To evaluate the biofidelity of the RID2 anthropometric test dummy on the basis of calculated neck injury criterion (NIC) values by comparing these values to those obtained from human subjects exposed in the very same crashes. The widely used and familiar hybrid III dummy has been said to lack biofidelity in the special application of low speed rear impact crashes. Several attempts have been made to modify this dummy with only marginal success. Two completely new dummies have been developed; the BioRID and the RID2. Neither have been tested under real world crash boundary conditions in side-by-side comparisons with live human subjects. Volunteer subjects, including a 50th percentile male, a 95th percentile male, and a 50th percentile female, were placed in the driver's seat of a vehicle and subjected to a series of three low speed rear impact crashes each. The RID2 dummy, which is modeled after a 50th percentile male, was placed in the passenger seat in each case. Both subjects and dummy were fully instrumented and acceleration-time histories were recorded. From this data, velocities of the heads and torsos were determined and both were used to calculate the NIC values for both crash test subjects and the RID2. The RID2 demonstrated generally higher head accelerations and NIC values than those of the human subjects. Most of the observed variations might be explained on the basis of differing head restraint geometry, posture, and body size. The RID2 NIC values compared most favorably with those of the 50th percentile male subject. For the whole group, the correlations between RID2 and human subjects did not reach statistical significance. The small number of test subjects and crash tests limited the statistical power of this pilot study, and the correlation between the RID2 and human subject NIC values were not

Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects

Science.gov (United States)

Ushijima, Kentarou; Tsuruoka, Shu-ichi; Tsuda, Hidetoshi; Hasegawa, Gohki; Obi, Yuri; Kaneda, Tae; Takahashi, Masaki; Maekawa, Tomohiro; Sasaki, Tomohiro; Koshimizu, Taka-aki; Fujimura, Akio

2009-01-01

AIM To investigate a potential interaction between cranberry juice and diclofenac, a substrate of CYP2C9. METHODS The inhibitory effect of cranberry juice on diclofenac metabolism was determined using human liver microsome assay. Subsequently, we performed a clinical trial in healthy human subjects to determine whether the repeated consumption of cranberry juice changed the diclofenac pharmacokinetics. RESULTS Cranberry juice significantly suppressed diclofenac metabolism by human liver microsomes. On the other hand, repeated consumption of cranberry juice did not influence the diclofenac pharmacokinetics in human subjects. CONCLUSIONS Cranberry juice inhibited diclofenac metabolism by human liver microsomes, but not in human subjects. Based on the present and previous findings, we think that although cranberry juice inhibits CYP2C9 activity in vitro, it does not change the pharmacokinetics of medications metabolized by CYP2C9 in clinical situations. PMID:19694738

Atmospheric pollution biomonitoring of the Sao Paulo metropolitan region using epiphytic lichens; Uso de liquens epifiticos no biomonitoramento da poluicao atmosferica da regiao metropolitana de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Fuga, Alessandra

2006-07-01

Due to the increasing problems of atmospheric pollution in the Sao Paulo metropolitan region that affect the environment and human health the application of biomonitoring methodologies using cosmopolite organisms has now become relevant. Biomonitoring is a method to evaluate the response of live organisms to pollution. This method offers advantages such as reduced costs, efficient monitoring of large geographic areas and accumulated pollutants over a large period in which low concentrations of chemicals elements in the environment can be evaluated. In the present study, neutron activation analysis method was applied to determine elements accumulated in Canoparmelia texana lichenized fungi. Samples were collected in two distinct areas: Carlos Botelho (PECB) and Intervales (PEI) State Parks that are considered as non-polluted areas and that belong to the Atlantic Forest - SP ecosystem; and Sao Paulo city metropolitan region in sites near automatic monitoring stations of the Environmental Protection Agency of the State of Sao Paulo (CETESB). The lichens collected from the bark of the trees were properly treated, and irradiated with neutrons from IEA-R1 nuclear reactor along with synthetic standards of elements. The precision and the accuracy of the results were evaluated by the analyses of IAEA-336 LICHEN and Mixed Polish Herbs (INCT -MPH-2) certified reference materials. The results obtained for these materials were in accordance with the certified values and presented good precision with variation coefficients ranging from 0.9 to 14.6%. Results obtained for lichens showed that elements As, Co, Cr, Cs, La, Mo, Sb, Sc, Se and U are present at ng g{sup -1} levels, Ba, Br, Cl, Fe, K, Mn, Na, Rb and Zn at {mu}g g{sup -1} and Ca at mg g{sup -1}. By applying cluster and discriminant analyses to the results for the lichen samples from areas with different levels of pollution, the sampling sites were grouped according to their chemical similarities and their elemental

Results of Occupational Monitoring Program in Technologic Navy Center in Sao Paulo

International Nuclear Information System (INIS)

Perez, Clarice F.A.; Bitelli, Ricardo D.; Oliveira, Rodemir

2013-01-01

The CTMSP, Centro Tecnologico da Marinha em Sao Paulo, is a nuclear research Center located in the State of Sao Paulo. CTMSP headquarters is placed at the Campus of the University of Sao Paulo. Most of CTMSP nuclear facilities are at the Centro Experimental Aramar (CEA), located 120 km northwest from the Capital city of Sao Paulo. CTMSP has two major nuclear programs. One is the development of a PWR reactor for naval propulsion, and the other is associated with the front end fuel cycle technology comprising enrichment, conversion and reconversion. These activities require an extensive area monitoring program. This paper presents the results of this program covering the years of 2003 to 2011. The results include surface monitoring, dose rates and uranium concentrations in the air. (author)

Atmospheric alcohols and aldehydes concentrations measured in Osaka, Japan and in Sao Paulo, Brazil

International Nuclear Information System (INIS)

Nguyen, Ha Thi-Hoang; Takenaka, Norimichi; Bandow, Hiroshi; Maeda, Yasuaki; Oliva, S.T. de; Botelho, M.M.; Tavares, T.M.

2001-01-01

The use of alcohol fuel has received much attention since the 1980s. In Brazil, ethanol-fuelled vehicles have been currently used on a large scale. This paper reports the atmospheric methanol and isoproponal concentrations which were measured from May to December 1997, in Osaka, Japan, where alcohol fuel was not used and from 3 to 9 February 1998 in Sao Paulo, Brazil, where ethanol was used. The alcohols were determined by the alkyl nitrite formation reaction using gas chromatography (GC-ECD) analysis. The concentration of atmospheric alcohols, especially ethanol, measured in Sao Paulo were significantly higher than those in Osaka. In Osaka, the average concentrations of atmospheric methanol, ethanol, and isopropanol were 5.8 ± 3.8, 8.2 ± 4.6, and 7.2 ± 5.9ppbv, respectively. The average ambient levels of methanol, ethanol, and isopropanol measured in Sao Paulo were 34.1± 9.2, 176.3 ± 38.1, and 44.2 ± 13.7ppbv, respectively. The ambient levels of aldehydes, which were expected to be high due to the use of alcohol fuel, were also measured at these sampling sites. The atmospheric formaldehyde average measured in Osaka was 1.9± 0.9ppbv, and the average acetaldehyde concentration was 1.5 ± 0.8ppbv. The atmospheric formaldehyde and acetaldehyde average concentrations measured in Sao Paulo were 5.0 ± 2.8 and 5.4 ± 2.8ppbv, respectively. The C 2 H 5 OH/CH 3 OH and CH 3 CHO/HCHO were compared between the two measurement sites and elsewhere in the world, which have already been reported in the literature. Due to the use of ethanol-fuelled vehicles, these ratios, especially C-2H 5 OH/CH 3 OH, are much higher in Brazil than those measured elsewhere in the world. (Author)

[Ethics and laws related to human subject research].

Science.gov (United States)

Chiu, Hui-Ju; Lee, Ya-Ling; Chang, Su-Fen

2011-10-01

Advances in medical technology rely on human subject research to test the effects on real patients of unproven new drugs, equipment and techniques. Illegal human subject research happens occasionally and has led to subject injury and medical disputes. Familiarity with the laws and established ethics related to human subject research can minimize both injury and disputes. History is a mirror that permits reflection today on past experience. Discussing the Nuremberg Code, the Declaration of Helsinki and Belmont Report, this article describes the laws, ethics, history and news related to human subject research as well as the current definition and characteristics of human subject research. Increasing numbers of nurses serve as research nurses and participate in human subject research. The authors hope this article can increase research nurse knowledge regarding laws and ethics in order to protect human research subjects adequately.

Radar cross section of human cardiopulmonary activity for recumbent subject.

Science.gov (United States)

Kiriazi, John E; Boric-Lubecke, Olga; Lubecke, Victor M

2009-01-01

The radar cross section (RCS) corresponding to human cardio-respiratory motion is measured for a subject in two different recumbent positions. Lying face-up (supine), the subject showed an RCS of 0.326 m(2). But when lying face-down (prone), the RCS increased to 2.9 m(2). This is the first reported RCS measurement corresponding to human cardio-respiratory motion. The results obtained in this experiment suggest modeling the upper part of the human body as a half-cylinder where the front body corresponds to the cylindrical surface and the back corresponds to the rectangular one.

Atmospheric pollution biomonitoring of the Sao Paulo metropolitan region using epiphytic lichens

International Nuclear Information System (INIS)

Fuga, Alessandra

2006-01-01

Due to the increasing problems of atmospheric pollution in the Sao Paulo metropolitan region that affect the environment and human health the application of biomonitoring methodologies using cosmopolite organisms has now become relevant. Biomonitoring is a method to evaluate the response of live organisms to pollution. This method offers advantages such as reduced costs, efficient monitoring of large geographic areas and accumulated pollutants over a large period in which low concentrations of chemicals elements in the environment can be evaluated. In the present study, neutron activation analysis method was applied to determine elements accumulated in Canoparmelia texana lichenized fungi. Samples were collected in two distinct areas: Carlos Botelho (PECB) and Intervales (PEI) State Parks that are considered as non-polluted areas and that belong to the Atlantic Forest - SP ecosystem; and Sao Paulo city metropolitan region in sites near automatic monitoring stations of the Environmental Protection Agency of the State of Sao Paulo (CETESB). The lichens collected from the bark of the trees were properly treated, and irradiated with neutrons from IEA-R1 nuclear reactor along with synthetic standards of elements. The precision and the accuracy of the results were evaluated by the analyses of IAEA-336 LICHEN and Mixed Polish Herbs (INCT -MPH-2) certified reference materials. The results obtained for these materials were in accordance with the certified values and presented good precision with variation coefficients ranging from 0.9 to 14.6%. Results obtained for lichens showed that elements As, Co, Cr, Cs, La, Mo, Sb, Sc, Se and U are present at ng g -1 levels, Ba, Br, Cl, Fe, K, Mn, Na, Rb and Zn at μg g -1 and Ca at mg g -1 . By applying cluster and discriminant analyses to the results for the lichen samples from areas with different levels of pollution, the sampling sites were grouped according to their chemical similarities and their elemental composition. It was

Problems of small hydroelectric power plants - SHP: the example of Sao Paulo State, Brazil; Problematica de desenvolvimento das pequenas centrais hidreletricas-PCH: o exemplo do Estado de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Matajs, R.R. [Sao Paulo Univ., SP (Brazil). Programa Interunidades de Pos-Graduacao em Energia; Fabrizy, M.P. [Sao Paulo Univ., SP (Brazil). Inst. de Eletrotecnica e Energia

1994-07-01

This paper presents a survey of the small hydroelectric potential in the State of Sao Paulo - Brazil. Three projections will be presented as as attempt to show the possible participation of the SHP in a sort, medium and long term, in the State of Sao Paulo energetic matrix.

Nuclear technology in secondary school in the city of Sao Paulo

International Nuclear Information System (INIS)

Benites, Daniela B.; Gordon, Ana Maria P.L.

2009-01-01

Nowadays, much has been said about nuclear technology development in Brazil. The importance of introducing the nuclear energy in the Brazilian energetic matrix has been now recognized by the society. There is a highly accepted assertion about the role developed by the energy offer for the country development, although it is wellknown that this is a necessary condition, but not enough. Another major issue is the environment preservation, so that future generations may live in adequate climatic and environmental conditions. Industrial activities and mining are some of the issues debated in the world scenario. Therefore the option to introduce nuclear energy in the country energetic matrix is a decision that should be supported by its knowledge. Nevertheless, do the youth know what nuclear energy is? What this kind of technology applications and implications are? To answer these questions, this project aims to analyze to what extent secondary schools are aware of nuclear technology and its applications, to verify whether there are the minimal necessary conditions for their interpretation and comprehension of related phenomena, as well as to analyze whether these students are able to critically opine on this subject. The methodology consists in using, as a data collection tool, a questionnaire applied to the students. For this purpose, the research field is constituted of the third year secondary school students, from public state schools, in the city of Sao Paulo. The data survey was restricted to schools belonging to three levels of classification, in the National Examination of Secondary Schools 2007. The questions proposed in the questionnaire were elaborated in considering what students, according to their age, were supposed to know concerning nuclear technology having as reference the 'Leis de Diretrizes e Bases da Educacao Nacional' (National Education Guidance Law), the 'Parametros Curriculares Nacionais' (National Curricula Parameters) and basic nuclear

Challenges in modern biomarker discovery--17th HUPO BPP workshop: May 24-25, 2012, Sao Paulo, Brazil.

Science.gov (United States)

Gröttrup, Bernd; Esselmann, Hermann; May, Caroline; Schrötter, Andreas; Woitalla, Dirk; Heinsen, Helmut; Marcus, Katrin; Wiltfang, Jens; Meyer, Helmut E; Grinberg, Lea T; Park, Young Mok

2013-01-01

The HUPO Brain Proteome Project (HUPO BPP) held its 17(th) workshop in Sao Paulo, Brazil, on May 24 and 25, 2012. The focus was on the progress on the Human Brain Proteome Atlas as well as ideas, strategies and methodological aspects in clinical neuroproteomics. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Optimization of the daily operation of the plants of Medio Sao Francisco; Otimizacao da operacao diaria das usinas do Medio Sao Francisco

Energy Technology Data Exchange (ETDEWEB)

Fernandes, Jessica Pillon Torralba; Colnago, Glauber Renato; Correia, Paulo de Barros; Ohishi, Takaaki [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Fac. de Engenharia Mecanica. Dept. de Energia], emails: pillon@fem.unicamp.br, colnago@fem.unicamp.br, pcorreia@fem.unicamp.br, taka@densis.fee.unicamp.br

2010-07-01

This paper presents an optimization model for daily operation of Sao Francisco hydroelectric power plants. The study considers eight power plants - Sobradinho (USB), Luiz Gonzaga (ULG), Apolonio Sales (UAS), Paulo Afonso I, II, III, (UPA), Paulo Afonso IV (USQ) e Xingo (UXG)- belongs to Sao Francisco Hydroelectric Company (CHESF). Its objective is to maximize the power plant efficiency and to minimize the number of startup and shutdowns of generating units (GU), simultaneously. Considering those GU are equal, is determined the number of units to be dispatched and their charge. The optimal dispatch, linear and non-linear programming techniques and genetic algorithms (GA) support this article. (author)

Thyroid Cancer Incidence Patterns in Sao Paulo, Brazil, and the U.S. SEER Program, 1997–2008

Science.gov (United States)

Neta, Gila; Aschebrook-Kilfoy, Briseis; Ron, Elaine; Devesa, Susan S.

2013-01-01

Background Thyroid cancer incidence has risen steadily over the last few decades in most of the developed world, but information on incidence trends in developing countries is limited. Sao Paulo, Brazil, has one of the highest rates of thyroid cancer worldwide, higher than in the United States. We examined thyroid cancer incidence patterns using data from the Sao Paulo Cancer Registry (SPCR) in Brazil and the National Cancer Institute's Surveillance Epidemiology End Results (SEER) program in the United States. Methods Data on thyroid cancer cases diagnosed during 1997–2008 were obtained from SPCR (n=15,892) and SEER (n=42,717). Age-adjusted and age-specific rates were calculated by sex and histology and temporal patterns were compared between the two populations. Results Overall incidence rates increased over time in both populations and were higher in Sao Paulo than in the United States among females (SPCR/SEER incidence rate ratio [IRR]=1.65) and males (IRR=1.23). Papillary was the most common histology in both populations, followed by follicular and medullary carcinomas. Incidence rates by histology were consistently higher in Sao Paulo than in the United States, with the greatest differences for follicular (IRR=2.44) and medullary (IRR=3.29) carcinomas among females. The overall female/male IRR was higher in Sao Paulo (IRR=4.17) than in SEER (IRR=3.10) and did not change over time. Papillary rates rose over time more rapidly in Sao Paulo (annual percentage change=10.3% among females and 9.6% among males) than in the United States (6.9% and 5.7%, respectively). Regardless of sex, rates rose faster among younger people (8 among both Sao Paulo males and females, in contrast to increases from 9 to 12 and from 6 to 7 among U.S.males and females, respectively. Conclusions Increased diagnostic activity may be contributing to the notable rise in incidence, mainly for papillary type, in both populations, but it is not likely to be the only reason. Differences in

Effects of air pollutants on the carbon dioxide (CO2) emission rate of human subjects

DEFF Research Database (Denmark)

Bako-Biro, Zsolt; Wargocki, Pawel; Wyon, David

2004-01-01

Several laboratory studies have shown the negative effects of emissions from typical indoor pollution sources on perceived air quality, SBS symptoms and the performance of office work. The subjects performed typical office tasks at their own pace while they were exposed for several hours to diffe...... to different air quality conditions. A re-analysis of the CO2 measurements obtained in two independent studies showed that human CO2 emission rates were affected by air quality (P......Several laboratory studies have shown the negative effects of emissions from typical indoor pollution sources on perceived air quality, SBS symptoms and the performance of office work. The subjects performed typical office tasks at their own pace while they were exposed for several hours...

Energy balance of the state of Sao Paulo - 2015: calendar year 2014; Balanco energetico do estado de Sao Paulo - 2015: ano base 2014

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-07-01

The State Energy Report 2015 prepared by the Secretariat of Energy, is the publication of the State Government that shows the supply and demand of energy used by the state economy, with the corresponding participation of the sectors involved. The energy policy of the State of Sao Paulo's strategic objective of expanding the energy supply from the load centers, energy security and expanding the share of renewable sources in the matrix. In order to achieve these objectives it is essential that count on complete and reliable information on the supply and demand of energy. This information is needed not only to the Secretary of Energy, in the formulation and implementation of state programs, but the municipalities and regions of the state so that they can formulate and present their demands as clearly as possible. It is therefore the production of strategic information to the counties together with the State Government to plan its priorities in energy and services. The publication is essential reading for all who work with energy planning studies, feasibility of innovative technologies, search for energy efficiency and environmental protection. The evolution of the energy matrix of the State of Sao Paulo is one of the Balance sheet highlights, showing a greater share of biomass and natural gas since the mid- 90s . This issue also reports on CO{sub 2} emissions in the state, historical data vintages of the Sao Paulo sugarcane sector and a breakdown of electricity and derived from oil and gas. Thus, the State Energy Balance 2015 becomes an important tool aimed at implementation of public policies relevant to the infrastructure sector. (author)

Overseas dispersal of Hyperolius reed frogs from Central Africa to the oceanic islands of Sao Tomé and Príncipe

Czech Academy of Sciences Publication Activity Database

Bell, R. C.; Drewes, R. C.; Channing, A.; Gvoždík, Václav; Kielgast, J.; Lötters, S.; Stuart, B. L.; Zamudio, K. R.

2015-01-01

Roč. 42, č. 1 (2015), s. 65-75 ISSN 0305-0270 Institutional support: RVO:68081766 Keywords : Central Africa * Congo River * Gulf of Guinea * Hyperolius * long -distance dispersal * oceanic island * biogeography * phylogeography * Príncipe * Sao Tomé * species tree Subject RIV: EG - Zoology Impact factor: 3.997, year: 2015

137Cs inventory in sedimentary columns from continental shelf of Sao Paulo state

International Nuclear Information System (INIS)

Figueira, Rubens C.L.; Cordero, Luisa M.; Mahiques, Michel M. de; Tessler, Moyses G.

2009-01-01

137 Cs is an artificial radioactive isotope produced by 235 U fission. This radionuclide has a high fission yield and a half-life of 30 years. It has been detected in the environment since 1945 and its principal contamination source has been nuclear tests in the atmosphere. There are other sources of 137 Cs contamination in the environment, such as: release from nuclear and reprocessing plants, radioactive dumping and nuclear accidents (Chernobyl, for example). This paper presents an inventory of 137 Cs on the Continental Shelf of Sao Paulo State, a region located between Cabo de Santa Marta Grande (Santa Catarina state) and Cabo Frio (Rio de Janeiro state). In this area, 9 cores were collected by the Instituto Oceanografico da Universidade de Sao Paulo (Sao Paulo University Institute of Oceanography). The cores were sliced at every 2 cm; sub-samples were lyophilized, grinded and stored in plastic containers. 137 Cs was determined by 661 keV photopeak using a gamma spectrometry detector (Ge hyperpure). The analysis was performed by efficiency and background in different counting times. 137 Cs concentration activities varied from 0.3 to 3.6 Bq kg -1 with a mean value of 1.2±0.6 Bq kg -1 . The inventory of 137 Cs in this area was 13±7 Bq m-2. Values obtained are in agreement with the Southern Hemisphere, a region contaminated by atmospheric fallout due to past nuclear explosions. (author)

Uranium occurrence at Sao Teodosio farm, Currais Novos, Rio Grande do Norte, Brazil

International Nuclear Information System (INIS)

Favali, J.C.; Leal, J.R.L.V.

1974-01-01

The areas of certain radiometric anomalies discovered in Serido geosyncline were selected for intensive study because of the similarity of the geology to that of known uranium deposits in other parts of the world. The uranium mineralization at Sao Teodosio farm, near Currais Novos, RN, on the Serrinha anticline axis, occurs in alaskite similar to that at Rossing in Southwest Africa. The Rossing deposit is the best example of the model proposed by Armstrong (1974) as 'porphyry' uranium deposits. That uranium deposit presents low grade of uranium content, about 0,030% U 3 O 8 and hundred thousands tons of uranium oxide. At Sao Teodosio occurs 550 m.y. alaskitic pegmatitic granite and garnet-quartz-biotite-schists of Serido formation, Upper Precambrian. These older rocks are cut by diabases dykes of Upper Terciary age. Uranium mineralization is associated with pegmatitic granite bodies similar to dykes and sills. The most common uranium minerals are: uraninite, meta-autunite and uranophane. Oligoclase, microline and quartz are the most frequent minerals. Acessory minerals are magnetite, titanite and zircon. Uranium oxide content at Sao Teodosio is 0,023% and average thickness is 2,80 m [pt

SEGMENTATION IN TOURISTIC SECTOR: LGBT TOURISTS OF SAO PAULO

Directory of Open Access Journals (Sweden)

Maurício Sanitá Azevedo

2012-05-01

Full Text Available The objective of this article is to present the tourism segment LGBT (Lesbian, Gays, Bisexual and Transgender of Sao Paulo city and gather information about his profile as important support for the tourism sector in defining their marketing strategies. It was carried out an exploratory and statistical data from government and representatives of this public for a description and analysis of data on the composition and profile of this segment, as well as the strategies being used by companies to captivate it and loyalty it. It also composes a Descriptive Study carried out by the Tourism Observatory of São Paulo next to the participants of the Sao Paulo Gay Parade in 2011. As results, it appears that LGBT public presents behavioral particularities as buyers of tourist products, providing during their stay, higher investments than others tourism segments, because it comes as a tourist for a longer period of stay in Sao Paulo, thus leaving more financial resources in the city. It also presents as results, examples of effective use of differentiation strategies by organizations, attraction, service and loyalty in this segment.

The expansion of sugar cane cultivation in the Sao Paulo state, Brazil; A expansao da cultura canavieira no estado de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Coelho, Suani Teixeira [Centro Nacional de Referencia em Biomassa (CENBIO), Sao Paulo, SP (Brazil); Lora, Beatriz Acquaro; Monteiro, Maria Beatriz C.A.

2008-07-01

The present work aimed at analyze the sugar cane culture expansion in substitution to the other cultures in the Sao Paulo state from available georeferred and statistical data. The results had evidenced clear expansion of the sugar cane culture in the state, having totalized a growth of 26.04% in the period from 2003 to 2006, with expressive increase in the regions of President Prudente, Sao Jose do Rio Preto, Barretos and Marilia that had, each one, more than 40% of increase in the period. Concomitantly it had reduction of the maize areas in the studied region and pasture areas stability, followed of a small increase of the cattle heads number. (author)

Characterization of human myotubes from type 2 diabetic and non-diabetic subjects using complementary quantitative mass spectrometric methods

DEFF Research Database (Denmark)

Thingholm, Tine E; Bak, Steffen; Beck-Nielsen, Henning

2011-01-01

2 diabetes. Several abnormalities have been identified in skeletal muscle from type 2 diabetic subjects, however, the exact molecular mechanisms leading to the diabetic phenotype has still not been found. Here we present a large-scale study in which we combine a quantitative proteomic discovery...... strategy using iTRAQ and a label-free study with a targeted quantitative proteomic approach using selected reaction monitoring (SRM) to identify, quantify and validate changes in protein abundance between human myotubes obtained from non-diabetic lean, non-diabetic obese and type 2 diabetic subjects...

[Travelling together: an experience in sex education in the area surrounding Sao Paulo].

Science.gov (United States)

Barroso, C; Simonetti, C; Vieira, E

1983-05-01

This study describes group discussions of female sexuality held in a Sao Paulo Mothers' Club for the purpose of educating participants and producing educational pamphlets for publication. The participant research methodology is an attempt to integrate feminism with academic practice; the research is to be used to improve the condition of the research subjects and the research process itself is seen as educational. Participants were 8-15 low-income housewives 25-33 years old, with low level reading skills. In a series of discussion meetings, topics of interest identified included the physiology of the human body, sex education of children, and methods of contraception. Drafts of pamphlets and illustrations were presented for the immediate feedback of the group. Additional topics included the role of women in the family and society, women's rights, traditional class beliefs and myths about sexuality, medical care and examinations, and self-examination. 5 pamphlets and an accompanying manual for their use were produced for distribution to women's groups throughout Brazil. These include: Understanding Our Body; Do I want to be a Mother?; When Children Ask Certain Things; A gynecological Exam; and Much Pleasure.

Human subject research for engineers a practical guide

CERN Document Server

de Winter, Joost C F

2017-01-01

This Brief introduces engineers to the main principles in ethics, research design, statistics, and publishing of human subject research. In recent years, engineering has become strongly connected to disciplines such as biology, medicine, and psychology. Often, engineers (and engineering students) are expected to perform human subject research. Typical human subject research topics conducted by engineers include human-computer interaction (e.g., evaluating the usability of software), exoskeletons, virtual reality, teleoperation, modelling of human behaviour and decision making (often within the framework of ‘big data’ research), product evaluation, biometrics, behavioural tracking (e.g., of work and travel patterns, or mobile phone use), transport and planning (e.g., an analysis of flows or safety issues), etc. Thus, it can be said that knowledge on how to do human subject research is indispensable for a substantial portion of engineers. Engineers are generally well trained in calculus and mechanics, but m...

Consequências cardiovasculares na SAOS Cardiovascular consequences of obstructive sleep apnea syndrome

Directory of Open Access Journals (Sweden)

Geraldo Lorenzi Filho

2010-06-01

Full Text Available Uma condição clínica muito comum é SAOS, que está associada a várias doenças cardiovasculares, incluindo hipertensão arterial sistêmica, fibrilação atrial e aterosclerose. A associação entre SAOS e doença cardiovascular não é somente uma consequência da sobreposição de fatores de risco, incluindo obesidade, sedentarismo, ser do sexo masculino e ter idade maior. Existem evidências crescentes de que SAOS contribui de forma independente para o aparecimento e a progressão de várias doenças cardiovasculares. Os mecanismos pelos quais SAOS pode afetar o sistema cardiovascular são múltiplos e incluem a ativação do sistema nervoso simpático, inflamação sistêmica, resistência a insulina e geração de estresse oxidativo. Existem evidências que o tratamento de SAOS com CPAP pode reduzir a pressão arterial, sinais precoces de aterosclerose, risco de recorrência de fibrilação atrial e mortalidade, principalmente por acidente vascular cerebral e infarto agudo do miocárdio, em pacientes com SAOS grave.Obstructive sleep apnea syndrome (OSAS is a common condition associated with various cardiovascular diseases, including systemic arterial hypertension, atrial fibrillation, and atherosclerosis. The association between OSAS and cardiovascular disease has been related to the overlapping of risk factors, including obesity, having a sedentary lifestyle, being male, and being older. However, there is mounting evidence that OSAS can also independently contribute to the development and progression of various cardiovascular diseases. The mechanisms by which OSAS can affect the cardiovascular system are multiple, including the activation of the sympathetic nervous system, systemic inflammation, insulin resistance, and oxidative stress. There is also evidence that the treatment of OSAS with CPAP can reduce arterial blood pressure, early signs of atherosclerosis, the risk of atrial fibrillation recurrence, and mortality (principally

TiO2 nanoparticles disrupt cell adhesion and the architecture of cytoskeletal networks of human osteoblast-like cells in a size dependent manner.

Science.gov (United States)

Ibrahim, Mohamed; Schoelermann, Julia; Mustafa, Kamal; Cimpan, Mihaela R

2018-04-30

Human exposure to titanium dioxide nanoparticles (nano-TiO 2 ) is increasing. An internal source of nano-TiO 2 is represented by titanium-based orthopedic and dental implants can release nanoparticles (NPs) upon abrasion. Little is known about how the size of NPs influences their interaction with cytoskeletal protein networks and the functional/homeostatic consequences that might follow at the implant-bone interface with regard to osteoblasts. We investigated the effects of size of anatase nano-TiO 2 on SaOS-2 human osteoblast-like cells exposed to clinically relevant concentrations (0.05, 0.5, 5 mg/L) of 5 and 40 nm spherical nano-TiO 2 . Cell viability and proliferation, adhesion, spread and migration were assessed, as well as the orientation of actin and microtubule cytoskeletal networks. The phosphorylation of focal adhesion kinase (p-FAK Y397 ) and the expression of vinculin in response to nano-TiO 2 were also assessed. Treatment with nano-TiO 2 disrupted the actin and microtubule cytoskeletal networks leading to morphological modifications of SaOS-2 cells. The phosphorylation of p-FAK Y397 and the expression of vinculin were also modified depending on the particle size, which affected cell adhesion. Consequently, the cell migration was significantly impaired in the 5 nm-exposed cells compared to unexposed cells. The present work shows that the orientation of cytoskeletal networks and the focal adhesion proteins and subsequently the adhesion, spread and migration of SaOS-2 cells were affected by the selected nano-TiO 2 in a size dependent manner. This article is protected by copyright. All rights reserved. © 2018 Wiley Periodicals, Inc.

Challenging research on human subjects: justice and uncompensated harms.

Science.gov (United States)

Napier, Stephen

2013-02-01

Ethical challenges to certain aspects of research on human subjects are not uncommon; examples include challenges to first-in-human trials (Chapman in J Clin Res Bioethics 2(4):1-8, 2011), certain placebo controlled trials (Anderson in J Med Philos 31:65-81, 2006; Anderson and Kimmelman in Kennedy Inst Ethics J 20(1):75-98, 2010) and "sham" surgery (Macklin in N Engl J Med 341:992-996, 1999). To date, however, there are few challenges to research when the subjects are competent and the research is more than minimal risk with no promise of direct benefit. The principal reason given for allowing research that is more than minimal risk without benefit is that we should respect the autonomy of competent subjects. I argue that though the moral intuitions informing respect for autonomy are sound, there is another set of intuitions regarding what we take to be just treatment of another when one agent knowingly causes or allows suffering on another agent. I argue that concerns generated by commutative justice serve as limitations on permissible research. I highlight our intuitions informing this notion of justice by appealing to work done on theodicy; what counts as a morally sufficient reason for God to allow suffering in humans is applicable also to the researcher-subject relationship. I conclude that all human subjects who are exposed to more than minimal risk research should enjoy the same actual protections (e.g., subpart D) as those given subjects who cannot consent.

Energy balance of Sao Paulo State, Brazil 2012. Calendar year 2011

International Nuclear Information System (INIS)

2012-01-01

The document presents the consolidated annual energy balances, which encompasses: Executive Summary; Participation of the Sao Paulo's Electric Energy in the National Context; Overview Energy Mix of the State of Sao Paulo; Final Consumption by Source; Final Consumption by Sectors in 2011; Contents of the Energy Balance for the State of Sao Paulo; Methodology; Summary of the period in analysis; Supply and Demand of energy by source; External trade of energy; Energy imports and export; Transformation center balances; Energy and Economy and Resources and energy Reserves. In this 2012 edition, we highlight the growth of gasoline consumption at the expense of ethanol, compared with previous years. The fall harvest of cane sugar and federal policies aimed at artificially support the price of gasoline are some of the factors that led to the fall in competitiveness of ethanol. Nowadays, it is up to the government to create policies to stimulate the supply of renewable fuels to replace fossil fuels. (author)

{sup 137}Cs inventory in sedimentary columns from continental shelf of Sao Paulo state

Energy Technology Data Exchange (ETDEWEB)

Figueira, Rubens C.L.; Cordero, Luisa M.; Mahiques, Michel M. de; Tessler, Moyses G., E-mail: rfigueira@usp.b [Universidade de Sao Paulo (USP), SP (Brazil). Inst. Oceanografico. Dept. de Oceanografia Fisica, Quimica e Geologica; Cruz, Jacson L.S. [Universidade Cruzeiro do Sul, Sao Paulo, SP (Brazil)

2009-07-01

{sup 137}Cs is an artificial radioactive isotope produced by {sup 235}U fission. This radionuclide has a high fission yield and a half-life of 30 years. It has been detected in the environment since 1945 and its principal contamination source has been nuclear tests in the atmosphere. There are other sources of {sup 137}Cs contamination in the environment, such as: release from nuclear and reprocessing plants, radioactive dumping and nuclear accidents (Chernobyl, for example). This paper presents an inventory of {sup 137}Cs on the Continental Shelf of Sao Paulo State, a region located between Cabo de Santa Marta Grande (Santa Catarina state) and Cabo Frio (Rio de Janeiro state). In this area, 9 cores were collected by the Instituto Oceanografico da Universidade de Sao Paulo (Sao Paulo University Institute of Oceanography). The cores were sliced at every 2 cm; sub-samples were lyophilized, grinded and stored in plastic containers. {sup 137}Cs was determined by 661 keV photopeak using a gamma spectrometry detector (Ge hyperpure). The analysis was performed by efficiency and background in different counting times. {sup 137}Cs concentration activities varied from 0.3 to 3.6 Bq kg{sup -1} with a mean value of 1.2+-0.6 Bq kg{sup -1}. The inventory of {sup 137}Cs in this area was 13+-7 Bq m-2. Values obtained are in agreement with the Southern Hemisphere, a region contaminated by atmospheric fallout due to past nuclear explosions. (author)

Formation of Human Subjectivity in Psychological Interactions with Nature

Directory of Open Access Journals (Sweden)

S A Mudrak

2014-12-01

Full Text Available The article outlines the current trends in the environmental psychological research of the peculiarities of developing the subject-subjective human relationship with nature: considering human habitat environment as a set of natural objects; studying certain natural sites as psychologically attributive elements of the environment; determining the psychological meaning of the «Human Habitat Environment»; giving the analysis of the problem of the subjectivity development in human interaction with the natural objects.

Hydro geochemistry of uranium in Aguas de Lindoia (Sao Paulo State)

International Nuclear Information System (INIS)

Silveira, E.G. da.

1992-01-01

A preliminary investigation concerning to the geochemical behaviour of uranium isotopes ( 233 U and 238 U) was performed on spring waters for Aguas de Lindoia city, Sao Paulo State. The reason for this study is because the natural radioactivity of these waters is poorly known, and no uranium content data have been published. Measurements of Uranium-238 contents and 234 U/ 238 U activity ratios in groundwaters were performed on the following springs issuing in the urban area from Aguas de Lindoia: Levissima I, Levissima II, Beleza, Sao Roque, Lindalia and Santa Izabel. (author)

76 FR 54408 - Human Subjects Research Protections: Enhancing Protections for Research Subjects and Reducing...

Science.gov (United States)

2011-09-01

... and Drug Administration 21 CFR Parts 50 and 56 Human Subjects Research Protections: Enhancing Protections for Research Subjects and Reducing Burden, Delay, and Ambiguity for Investigators; Extension of... Secretary of the Department of Health and Human Services (HHS) in coordination with the Office of Science...

Oil spill analysis in Sao Sebastiao Channel. Sao Paulo (SP) Brazil, from 1974 to 1994

International Nuclear Information System (INIS)

Poffo, Iris R.F.; Midaglia, Carmen L.; Heitzmann, Sueli R.; Caetano, Nelson; Cantao, Renato F.; Pompeia, Sergio L.; Eysink, Geraldo G.; Nakasaki, Akira

1996-01-01

Environmental accident files from PETROBRAS and CETEBS were studied. A total of 210 oil spill accidents were registered in Sao Sebastiao region (1974-1994), the oil reached the sea in 191 cases. The analysis was carried out by: cause of the accident, kind and amount of oil spilled, displacement of the oil spot, affected areas, dispersive used, amount of the oil and contaminated sands removes, waste disposal, and the relation between the wind direction intensity and the displacement of oil spot

Adhesion and differentiation of Saos-2 osteoblast-like cells on chromium-doped diamond-like carbon coatings.

Science.gov (United States)

Filova, Elena; Vandrovcova, Marta; Jelinek, Miroslav; Zemek, Josef; Houdkova, Jana; Jan Remsa; Kocourek, Tomas; Stankova, Lubica; Bacakova, Lucie

2017-01-01

Diamond-like carbon (DLC) thin films are promising for use in coating orthopaedic, dental and cardiovascular implants. The problem of DLC layers lies in their weak layer adhesion to metal implants. Chromium is used as a dopant for improving the adhesion of DLC films. Cr-DLC layers were prepared by a hybrid technology, using a combination of pulsed laser deposition (PLD) from a graphite target and magnetron sputtering. Depending on the deposition conditions, the concentration of Cr in the DLC layers moved from zero to 10.0 at.%. The effect of DLC layers with 0.0, 0.9, 1.8, 7.3, 7.7 and 10.0 at.% Cr content on the adhesion and osteogenic differentiation of human osteoblast-like Saos-2 cells was assessed in vitro. The DLC samples that contained 7.7 and 10.0 at.% of Cr supported cell spreading on day 1 after seeding. On day three after seeding, the most apparent vinculin-containing focal adhesion plaques were also found on samples with higher concentrations of chromium. On the other hand, the expression of type I collagen and alkaline phosphatase at the mRNA and protein level was the highest on Cr-DLC samples with a lower concentration of Cr (0-1.8 at.%). We can conclude that higher concentrations of chromium supported cell adhesion; however DLC and DLC doped with a lower concentration of chromium supported osteogenic cell differentiation.

Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways

Energy Technology Data Exchange (ETDEWEB)

Park, Hyunjin; Bergeron, Eric; Senta, Helena; Guillemette, Kim [Cell-Biomaterial Biohybrid Systems, Universite de Sherbrooke, Department of Chemical Engineering and Biotechnological Engineering, Canada J1K 2R1 (Canada); Beauvais, Sabrina [Cell-Biomaterial Biohybrid Systems, Universite de Sherbrooke, Department of Chemical Engineering and Biotechnological Engineering, Canada J1K 2R1 (Canada); Development of Bioprocess, Universite de Sherbrooke, Department of Chemical Engineering and Biotechnological Engineering, Canada J1K 2R1 (Canada); Blouin, Richard [Universite de Sherbrooke, Department of Biology, Canada J1K 2R1 (Canada); Sirois, Joel [Development of Bioprocess, Universite de Sherbrooke, Department of Chemical Engineering and Biotechnological Engineering, Canada J1K 2R1 (Canada); Faucheux, Nathalie, E-mail: Nathalie.Faucheux@Usherbrooke.ca [Cell-Biomaterial Biohybrid Systems, Universite de Sherbrooke, Department of Chemical Engineering and Biotechnological Engineering, Canada J1K 2R1 (Canada)

2010-08-27

Research highlights: {yields} We show for the first time the effect of sanguinarine (SA) on MG63 and SaOS-2 cells. {yields} SA altered osteosarcoma cell viability in a concentration and time dependent manner. {yields} SA induced osteosarcoma cell apoptosis and increased caspase-8 and -9 activities. {yields} SA decreased dose dependently the Bcl-2 protein level only in MG63 cells. {yields} SaOS-2 which are osteoblast-derived, seemed more resistant to SA than MG63. -- Abstract: The quaternary benzo[c]phenanthridine alkaloid sanguinarine inhibits the proliferation of cancerous cells from different origins, including lung, breast, pancreatic and colon, but nothing is known of its effects on osteosarcoma, a primary malignant bone tumour. We have found that sanguinarine alters the morphology and reduces the viability of MG-63 and SaOS-2 human osteosarcoma cell lines in concentration- and time-dependent manner. Incubation with 1 {mu}mol/L sanguinarine for 4 and 24 h killed more efficiently MG-63 cells than SaOS-2 cells, while incubation with 5 {mu}mol/L sanguinarine killed almost 100% of both cell populations within 24 h. This treatment also changed the mitochondrial membrane potential in both MG-63 and SaOS-2 cells within 1 h, caused chromatin condensation and the formation of apoptotic bodies. It activated multicaspases, and increased the activities of caspase-8 and caspase-9 in both MG-63 and SaOS-2 cells. These data highlight sanguinarine as a novel potential agent for bone cancer therapy.

The age of the rocks and the metamorphic episodes from the Southeastern of Sao Paulo state

International Nuclear Information System (INIS)

Tassinari, C.C.G.; Kawashita, K.; Schmuss, R. van; Taylor, P.N.

1988-01-01

Rb-Sr, Pb-Pb and U-Pb geochronologic studies carried out on precambrian rocks from the southeastern Sao Paulo state suggest a Complex geologic evolution during the Archean and Proterozoic times. This region is divided in five differents allochthonous terranes named Itapira-Amparo, Piracaiba-Jundiai, Sao Roque, Embu and Costeiro, separated by thrust and strike-slip faults. The Itapira-Amparo domain has a original history dating back to 3.4 Ga. and since 2.6 to 2.5 Ga. and 2.2 to 1.9 Ga. metamorphic rockformation episode occurred involving both mantle-derived magmas and recycled material. Supracrustal sequences developed around 1.4 Ga. The domain was locally reworked in 0.8 - 0.65 Ga. In the Piracaia-Jundiai the main rock-formation event occurred at 1.4 Ga., but this domian was affected by strong granization and migmatization episodes during the period 1.1 - 0.6 Ga. The third terrain is characterized by the Sao Roque metavolcanossedimentary sequence developed during the time period 1.8 - 0.7 Ga., and comprising two metamorphic superimposed events (1.4 and 0.8 - 0.7 Ga.). the post-tectonics granites ranging in ages from 0.7 to 0.55 Ga. Within the Embu terrain ages of 2.5, 1.4 and 0,75 Ga. were obtained for the metamorphic terrain, with post-tectonic activities around 650 Ma. In the Costeiro domain all the metamorphic rocks developed in late-Proterozoic time, with syntectonic phase around 650 Ma [pt

The impact of antipsychotic polytherapy costs in the public health care in Sao Paulo, Brazil.

Science.gov (United States)

Razzouk, Denise; Kayo, Monica; Sousa, Aglaé; Gregorio, Guilherme; Cogo-Moreira, Hugo; Cardoso, Andrea Alves; Mari, Jair de Jesus

2015-01-01

Guidelines for the treatment of psychoses recommend antipsychotic monotherapy. However, the rate of antipsychotic polytherapy has increased over the last decade, reaching up to 60% in some settings. Studies evaluating the costs and impact of antipsychotic polytherapy in the health system are scarce. To estimate the costs of antipsychotic polytherapy and its impact on public health costs in a sample of subjects with psychotic disorders living in residential facilities in the city of Sao Paulo, Brazil. A cross-sectional study that used a bottom-up approach for collecting costs data in a public health provider's perspective. Subjects with psychosis living in 20 fully-staffed residential facilities in the city of Sao Paulo were assessed for clinical and psychosocial profile, severity of symptoms, quality of life, use of health services and pharmacological treatment. The impact of polytherapy on total direct costs was evaluated. 147 subjects were included, 134 used antipsychotics regularly and 38% were in use of antipsychotic polytherapy. There were no significant differences in clinical and psychosocial characteristics between polytherapy and monotherapy groups. Four variables explained 30% of direct costs: the number of antipsychotics, location of the residential facility, time living in the facility and use of olanzapine. The costs of antipsychotics corresponded to 94.4% of the total psychotropic costs and to 49.5% of all health services use when excluding accommodation costs. Olanzapine costs corresponded to 51% of all psychotropic costs. Antipsychotic polytherapy is a huge economic burden to public health service, despite the lack of evidence supporting this practice. Great variations on antipsychotic costs explicit the need of establishing protocols for rational antipsychotic prescriptions and consequently optimising resource allocation. Cost-effectiveness studies are necessary to estimate the best value for money among antipsychotics, especially in low and middle

Therapeutic touch affects DNA synthesis and mineralization of human osteoblasts in culture.

Science.gov (United States)

Jhaveri, Ankur; Walsh, Stephen J; Wang, Yatzen; McCarthy, MaryBeth; Gronowicz, Gloria

2008-11-01

Complementary and alternative medicine (CAM) techniques are commonly used in hospitals and private medical facilities; however, the effectiveness of many of these practices has not been thoroughly studied in a scientific manner. Developed by Dr. Dolores Krieger and Dora Kunz, Therapeutic Touch is one of these CAM practices and is a highly disciplined five-step process by which a practitioner can generate energy through their hands to promote healing. There are numerous clinical studies on the effects of TT but few in vitro studies. Our purpose was to determine if Therapeutic Touch had any effect on osteoblast proliferation, differentiation, and mineralization in vitro. TT was performed twice a week for 10 min each on human osteoblasts (HOBs) and on an osteosarcoma-derived cell line, SaOs-2. No significant differences were found in DNA synthesis, assayed by [(3)H]-thymidine incorporation at 1 or 2 weeks for SaOs-2 or 1 week for HOBs. However, after four TT treatments in 2 weeks, TT significantly (p = 0.03) increased HOB DNA synthesis compared to controls. Immunocytochemistry for Proliferating Cell Nuclear Antigen (PCNA) confirmed these data. At 2 weeks in differentiation medium, TT significantly increased mineralization in HOBs (p = 0.016) and decreased mineralization in SaOs-2 (p = 0.0007), compared to controls. Additionally, Northern blot analysis indicated a TT-induced increase in mRNA expression for Type I collagen, bone sialoprotein, and alkaline phosphatase in HOBs and a decrease of these bone markers in SaOs-2 cells. In conclusion, Therapeutic Touch appears to increase human osteoblast DNA synthesis, differentiation and mineralization, and decrease differentiation and mineralization in a human osteosarcoma-derived cell line. (c) 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Surface Airways Observations (SAO) Hourly Data (1965-1981) (CDMP)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The dataset consists primarily of U.S. surface airways observations (SAO) data beginning in 1965 and extending through 1981. Note that a few stations have already...

Surface Airways Observations (SAO) Hourly Data 1928-1948 (CDMP)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The dataset consists of hourly U.S. surface airways observations (SAO). These observations extend as far back as 1928, from the time when commercial aviation began...

Sao Paulo Lightning Mapping Array (SP-LMA): Deployment, Operation and Initial Data Analysis

Science.gov (United States)

Blakeslee, R.; Bailey, J. C.; Carey, L. D.; Rudlosky, S.; Goodman, S. J.; Albrecht, R.; Morales, C. A.; Anseimo, E. M.; Pinto, O.

2012-01-01

An 8-10 station Lightning Mapping Array (LMA) network is being deployed in the vicinity of Sao Paulo to create the SP-LMA for total lightning measurements in association with the international CHUVA [Cloud processes of the main precipitation systems in Brazil: A contribution to cloud resolving modeling and to the GPM (Global Precipitation Measurement)] field campaign. Besides supporting CHUVA science/mission objectives and the Sao Luiz do Paraitinga intensive operation period (IOP) in November-December 2011, the SP-LMA will support the generation of unique proxy data for the Geostationary Lightning Mapper (GLM) and Advanced Baseline Imager (ABI), both sensors on the NOAA Geostationary Operational Environmental Satellite-R (GOES-R), presently under development and scheduled for a 2015 launch. The proxy data will be used to develop and validate operational algorithms so that they will be ready for use on "day1" following the launch of GOES-R. A preliminary survey of potential sites in the vicinity of Sao Paulo was conducted in December 2009 and January 2010, followed up by a detailed survey in July 2010, with initial network deployment scheduled for October 2010. However, due to a delay in the Sao Luiz do Paraitinga IOP, the SP-LMA will now be installed in July 2011 and operated for one year. Spacing between stations is on the order of 15-30 km, with the network "diameter" being on the order of 30-40 km, which provides good 3-D lightning mapping 150 km from the network center. Optionally, 1-3 additional stations may be deployed in the vicinity of Sao Jos dos Campos.

Cycling for Transportation in Sao Paulo City: Associations with Bike Paths, Train and Subway Stations.

Science.gov (United States)

Florindo, Alex Antonio; Barrozo, Ligia Vizeu; Turrell, Gavin; Barbosa, João Paulo Dos Anjos Souza; Cabral-Miranda, William; Cesar, Chester Luiz Galvão; Goldbaum, Moisés

2018-03-21

Cities that support cycling for transportation reap many public health benefits. However, the prevalence of this mode of transportation is low in Latin American countries and the association with facilities such as bike paths and train/subway stations have not been clarified. We conducted a cross-sectional analysis of the relationship between bike paths, train/subway stations and cycling for transportation in adults from the city of Sao Paulo. We used data from the Sao Paulo Health Survey ( n = 3145). Cycling for transportation was evaluated by a questionnaire and bike paths and train/subway stations were geocoded using the geographic coordinates of the adults' residential addresses in 1500-m buffers. We used multilevel logistic regression, taking account of clustering by census tract and households. The prevalence of cycling for transportation was low (5.1%), and was more prevalent in males, singles, those active in leisure time, and in people with bicycle ownership in their family. Cycling for transportation was associated with bike paths up to a distance of 500 m from residences (OR (Odds Ratio) = 2.54, 95% CI (Confidence interval) 1.16-5.54) and with the presence of train/subway stations for distances >500 m from residences (OR = 2.07, 95% CI 1.10-3.86). These results are important to support policies to improve cycling for transportation in megacities such as Sao Paulo.

Hydrogen peroxide production is not primarily increased in human myotubes established from type 2 diabetic subjects.

Science.gov (United States)

Minet, A D; Gaster, M

2011-09-01

Increased oxidative stress and mitochondrial dysfunction have been implicated in the development of insulin resistance in type 2 diabetes. To date, it is unknown whether increased mitochondrial reactive oxygen species (ROS) production in skeletal muscle from patients with type 2 diabetes is primarily increased or a secondary adaptation to environmental, lifestyle, and hormonal factors. This study investigates whether ROS production is primarily increased in isolated diabetic myotubes. Mitochondrial membrane potential, hydrogen peroxide (H(2)O(2)), superoxide, and mitochondrial mass were determined in human myotubes precultured under normophysiological conditions. Furthermore, the corresponding ATP synthesis was measured in isolated mitochondria. Muscle biopsies were taken from 10 lean subjects, 10 obese subjects, and 10 subjects with type 2 diabetes; satellite cells were isolated, cultured, and differentiated to myotubes. Mitochondrial mass, membrane potential/mitochondrial mass, and superoxide-production/mitochondrial mass were not different between groups. In contrast, H(2)O(2) production/mitochondrial mass and ATP production were significantly reduced in diabetic myotubes compared to lean controls (P production is not primarily increased in diabetic myotubes but rather is reduced. Moreover, the comparable ATP/H(2)O(2) ratios indicate that the reduced ROS production in diabetic myotubes parallels the reduced ATP production because ROS production in diabetic myotubes must be considered to be in a proportion comparable to lean. Thus, the increased ROS production seen in skeletal muscle of type 2 diabetic patients is an adaptation to the in vivo conditions.

Geological and technological characteristics of the Ball Clay of the Sao Paulo state

International Nuclear Information System (INIS)

Tanno, L.C.; Motta, J.F.M.; Cabral Junior, M.; Saka, S.; Souza, D.D.D.

1990-01-01

This paper shows preliminary geological and technological results of studies about ball clay in Sao Paulo State. The works had been carried out by the Institute of Research and technology (IPT) and sponsored by Prominerio, during 88. Ball clay is a special clay utilised in the whiteware industry, mainly in the body preparation of sanitaryware products. This raw material come from two sites in Brazil: Sao Simao and Oeiras. Samples from these two deposits had been studied and classified acording to their adequately in the ceramic process. On the other hand, more than 100 samples from several geological sites of the Sao Paulo State were studied in laboratories. Acording to preliminary tests some of them revealed similar characteristics as brazilian ball clays. These clays were characterized by granulometry analysis, X-ray diffraction and chemical analysis. (author) [pt

Subjective Quantitative Studies of Human Agency

Science.gov (United States)

Alkire, Sabina

2005-01-01

Amartya Sen's writings have articulated the importance of human agency, and identified the need for information on agency freedom to inform our evaluation of social arrangements. Many approaches to poverty reduction stress the need for empowerment. This paper reviews "subjective quantitative measures of human agency at the individual level." It…

Distribution of Th-232 and Th-228 in Santos and Sao Vicente Estuary, Sao Paulo, Brazil

Energy Technology Data Exchange (ETDEWEB)

Silva, P.S.C.; Mazzilli, B.P.; Favaro, D.I.T. [Instituto de Pesquisas Energeticas e Nucleares, Av. Lineu Prestes, 2242, Caixa Postal 05508-000, Cidade Universitaria, Sao Paulo (Brazil)]. e-mail: Pscsilva@ipen.br

2004-07-01

In the last decades considerable attention has been given to technologically enhanced natural occurring radioactive material (TENORM). Within this frame, of particular concern is the phosphate fertilizer industry. Santos Basin, located in Southwest Brazil, Sao Paulo State, comprising Santos and Sao Vicente estuarine system, is considered the most important industrial region of the country. Among the industrial activities present, phosphate fertilizer plants are responsible for the production of 69 millions tons of phosphogypsum waste, which is stockpiled in the surrounding environment. This waste concentrates radionuclides of the natural series originally present in the phosphate rock used as raw material. This study aims to evaluate the environmental impact of such activities in the sediments of the estuarine system. {sup 232} Th and {sup 228} Th concentrations in Santos and San Vicente estuary sediments were determined by Neutron activation analysis and Gamma spectrometry, respectively. {sup 232} Th concentration ranged from 6.5 to 198 Bq kg{sup -1} with mean value of 57 {+-} 39 Bq kg{sup -1}, for 42 samples. {sup 228} Th content varied from 12 to 110 Bq kg{sup -1} with a mean value of 74 {+-} 23 Bq kg{sup -1}, for 18 samples. It can be seen that the amount of {sup 232} Th is higher in the rivers close to the phosphogypsum piles, at least five points were identified as being affected by anthropogenic factor. (Author)

Distribution of Th-232 and Th-228 in Santos and Sao Vicente Estuary, Sao Paulo, Brazil

International Nuclear Information System (INIS)

Silva, P.S.C.; Mazzilli, B.P.; Favaro, D.I.T.

2004-01-01

In the last decades considerable attention has been given to technologically enhanced natural occurring radioactive material (TENORM). Within this frame, of particular concern is the phosphate fertilizer industry. Santos Basin, located in Southwest Brazil, Sao Paulo State, comprising Santos and Sao Vicente estuarine system, is considered the most important industrial region of the country. Among the industrial activities present, phosphate fertilizer plants are responsible for the production of 69 millions tons of phosphogypsum waste, which is stockpiled in the surrounding environment. This waste concentrates radionuclides of the natural series originally present in the phosphate rock used as raw material. This study aims to evaluate the environmental impact of such activities in the sediments of the estuarine system. 232 Th and 228 Th concentrations in Santos and San Vicente estuary sediments were determined by Neutron activation analysis and Gamma spectrometry, respectively. 232 Th concentration ranged from 6.5 to 198 Bq kg -1 with mean value of 57 ± 39 Bq kg -1 , for 42 samples. 228 Th content varied from 12 to 110 Bq kg -1 with a mean value of 74 ± 23 Bq kg -1 , for 18 samples. It can be seen that the amount of 232 Th is higher in the rivers close to the phosphogypsum piles, at least five points were identified as being affected by anthropogenic factor. (Author)

Differential Scavenging Among Pig, Rabbit, and Human Subjects.

Science.gov (United States)

Steadman, Dawnie Wolfe; Dautartas, Angela; Kenyhercz, Michael W; Jantz, Lee M; Mundorff, Amy; Vidoli, Giovanna M

2018-04-12

Different animal species have been used as proxies for human remains in decomposition studies for decades, although few studies have sought to validate their use in research aimed at estimating the postmortem interval. This study examines 45 pig, rabbit, and human subjects placed in three seasonal trials at the Anthropology Research Facility. In an earlier paper, we found that overall decomposition trends did vary between species that could be due to differential insect and scavenger behavior. This study specifically examines if scavenger behavior differs by carrion species. Daily photographs, game camera photographs, written observations, and Total Body Score (TBS) documented scavenging and decomposition changes. Results show that raccoons were the most commonly observed vertebrate scavenger, that scavenging was most extensive in winter, and that certain human subjects were preferred over other humans and all non-human subjects. Finally, scavenging activity greatly reduces the accuracy of postmortem interval estimates based on TBS. © 2018 American Academy of Forensic Sciences.

Origin and evolution of the Pirituba aluminous calc-alkalic magma, state of Sao Paulo, SE Brazil

International Nuclear Information System (INIS)

Wernick, Eberhard

1999-01-01

The origin and evolution of the Late Proterozoic calc-alkalic Pirituba magmatism near the city of Sao Paulo, State of Sao Paulo, SE Brazil, are presented and discussed on the basis of geological, petrographic, mineralogical, chemical (rocks and minerals), isotopic and zircon typology data. (author)

Application of gamma radiation for recovery of papers infected by fungi: case study about Sao Luiz do Paraitinga, SP, Brazil

Energy Technology Data Exchange (ETDEWEB)

Auada, Fernanda Mokdessi; Bardi, Marcelo Augusto Gonçalves; Machado, Luci Diva Brocardo, E-mail: fmokdessi@usp.br, E-mail: lmachado@ipen.br, E-mail: marcelo.bardi@usf.edu.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Universidade São Francisco (USF), Bragança Paulista, SP (Brazil)

2017-11-01

The material studied in this work was flooded in the city of Sao Luiz do Paraitinga, SP, Brazil on January 2010 during a record flood suffered by the river that pass through the region. The documentary collection belonging to the City Hall underwent emergency drying and recovery treatments including irradiation with gamma rays to the destruction of various cellulosic fungi. Seven record books with many pages in blank and presenting severe fungal and mold infestation were provided by the Public Archive of the State of Sao Paulo, in charge of the damaged official documents, as samples for the present investigation on the effects of gamma radiation in the recovery and preservation of paper supported collections that are victims of biological contamination. This study represents a very rare possibility of working with a real object of actual use, which suffered a real disaster, and not with material prepared in laboratory and subjected to a forged flood situation. (author)

Application of gamma radiation for recovery of papers infected by fungi: case study about Sao Luiz do Paraitinga, SP, Brazil

International Nuclear Information System (INIS)

Auada, Fernanda Mokdessi; Bardi, Marcelo Augusto Gonçalves; Machado, Luci Diva Brocardo

2017-01-01

The material studied in this work was flooded in the city of Sao Luiz do Paraitinga, SP, Brazil on January 2010 during a record flood suffered by the river that pass through the region. The documentary collection belonging to the City Hall underwent emergency drying and recovery treatments including irradiation with gamma rays to the destruction of various cellulosic fungi. Seven record books with many pages in blank and presenting severe fungal and mold infestation were provided by the Public Archive of the State of Sao Paulo, in charge of the damaged official documents, as samples for the present investigation on the effects of gamma radiation in the recovery and preservation of paper supported collections that are victims of biological contamination. This study represents a very rare possibility of working with a real object of actual use, which suffered a real disaster, and not with material prepared in laboratory and subjected to a forged flood situation. (author)

Challenges for energy efficiency in the buildings sector in the Sao Paulo State, Brazil; Desafios para eficiencia energetica no setor de edificios no estado de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Matos, Maria Ines; Parente, Virginia [Universidade de Sao Paulo (IEE/USP), SP (Brazil). Inst. de Eletrotecnica e Energia

2010-07-01

The consumption of energy in the building sector accounts for more than one third of the total final electricity consumption in Sao Paulo State. Considering that, the development of policy measures aiming at the promotion of energy efficiency in the sector should be encouraged. Analysed data reveals the continuing rise of energy consumption resulting form the high number of new buildings and the rising standards of the population in consequence of economic development. Besides this, the retrofit of old buildings presents a huge potential for energy savings. The article analyses and suggests the use of Building Codes as a suitable policy instrument for the Sao Paulo Sate reality. (author)

Committees for Ethics in Research involving human subjects.

Science.gov (United States)

Hossne, William Saad; Vieira, Sonia; De Freitas, Corina Bontempo Duca

2008-01-01

In Brazil since October 1996 there have been guidelines for research involving human subjects. Now human subjects know when their treatment is part of research. Deceit is no longer tolerated. But is not enough to say we offer an explanation to the potential subject and we offer a choice before he or she is confronted with an informed consent form. As in all professional activity, scientific investigation needs social controls. In Brazil, the ultimate responsibility of an investigation lies on the investigator, but in every institution where research is carried out there is a Committee for Ethics in Research. All Committees are subordinated to the National Commission of Ethics in Research, which is submitted to the Brazilian Institute of Health. During 2005 around 17,000 protocols involving 700,000 human subjects were revised by 475 Committees distributed all over the country. Approximately 7,000 people are now working in these Committees.

Human Resource Subjects Allocation and Students' Academic ...

African Journals Online (AJOL)

This study investigated human resource subjects' allocation and students' academic performance in Secondary Schools in Obudu, Nigeria. The relevant variables of teachers subject was used as independent variable while the dependent variables were students' academic performance. Six hundred teachers from 20 ...

Ionizing radiation population doses at Sao Paulo city, Brazil: open-pit gamma dose measurement

International Nuclear Information System (INIS)

Oliveira, Raimundo Enoch Rodrigues

2001-01-01

The effects of ionizing radiation to the human beings are well known for high and intermediate doses. As far as low level) radiation doses are concerned, there is no consensus. In order to get a better understanding of such effects it is necessary to assess the low doses with better accuracy. In this work, it was made an estimate of the annual ambient dose equivalent (H * (10)) to which the people are exposed in the city of Sao Paulo. Until now there are no data about it available in the literature. For the purpose of this evaluation, a map with various routes covering the largest and more representative area of the city was designed. The choice of points for data collection was made taking into account mainly the occupancy of the region. A portable gamma spectrometry system was used. It furnishes the rate of H * (10) and the measured gamma spectrum (in the range from 50 to 1670 keV) in the place of interest. The measurements were performed in a short time interval, since the gamma radiation arrives from a great extent of soil. Each measurement was done 1 m above the soil during 300 s. The rates of H * (10) varied from 33.1 to 152.3 nSv.h -1 , net values, obtained after subtraction of the cosmic rays contribution. The standard deviation was 22 n Sv.h -1 for an average for the city of Sao Paulo of 96.1(24) nSv.h -1 . In addition, average values of H * (10) rates for the city Health Divisions were calculated. Those values are not statistically equivalent and the whole set of data could not be treated as one, as the statistical Student test indicated a non homogeneity of the group of data. Hence it is necessary the accomplishment of a more detailed survey in order to verify the origin of the discrepancy. The mean value of H * (10) rate obtained for the city of Sao Paulo as converted to effective dose. in order to be compared with other places results It could be noticed that the annual average of effective dose for the city of Sao Paulo, 0.522(13) mSv, is superior to

Issues in protection of human subjects in internet research.

Science.gov (United States)

Im, Eun-Ok; Chee, Wonshik

2002-01-01

Despite the increasing use of the Internet among nurses, the use of the Internet in nursing research has been rarely discussed and critiqued in terms of issues in protection of human subjects. In this article, issues in protection of human subjects in Internet research are explored by analyzing an Internet study to propose directions for human protection in Internet research. Issues raised through the study include those related to (a) anonymity and confidentiality, (b) security, (c) self-determination and authenticity, (d) full disclosure, and (e) fair treatment. Based on discussion of the five issues, development of standardized guidelines, investigator triangulation, and information sharing are proposed as directions for protection of human subjects in Internet research.

Trace elements in the urban aerosol of Sao Paulo

International Nuclear Information System (INIS)

Orsini, C.M.Q.; Artaxo Netto, P.E.; Tabacniks, M.H.

1983-07-01

The first trace-element data-set measured on the atmosphere aerosol of Sao Paulo City, Brazil, is presented. These measurements have been based on samplings by 6-stage cascade impactors combined with the analytical procedure by the PIXE method of elementary analysis. (L.C.) [pt

Ethical and social implications of microdosing clinical trial (3). Radiological protection of human subjects in research

International Nuclear Information System (INIS)

Kurihara, Chieko

2008-01-01

Internal irradiation of human subjects in research is discussed. Radiological protection of human subjects in medical research in a framework of radiation protection is surveyed from a viewpoint of general life-ethics and research-ethics. A workshop 'On the internal irradiation of human subjects' to summarize special and systematic knowledge was organized by Research Center for Radiation Protection, National Institute of Radiological Sciences in the beginning of 2008. Activities of this workshop are introduced. Discussion covers also (1) Research ethics and radiation protection, (2) Fundamentals and applications of risk-benefit assessment, (3) Human subjects risk assessment in ICRP recommendation, (4) Mechanism of human subjects internal irradiation assessment, and (5) Present status and future prospects in Japan. (K.Y.)

Energy balance of the Sao Paulo State - 1991

International Nuclear Information System (INIS)

1993-01-01

The energy production and consumption for the several categories of the economy in the Brazilian State of Sao Paulo are presented. The data are given according to the energy source and to consumer sectors and information about the import, export, losses in the transformation and distribution of the several forms of energy is supplied. 18 figs., 120 tabs

Hydrogeological impacts evaluation like a subsidy for the hydroelectric reservoir installation in the Sao Paulo State, Brazil

International Nuclear Information System (INIS)

Albuquerque Filho, Jose Luiz; Bottura, Joao Alberto; Borin Junior, Tarcisio; Correa, Wilson Aparecido Garcia

1994-01-01

Hydrogeological studies developed in the influence areas of the big reservoirs at the Sao Paulo State, Sao Paulo/Mato Grosso do Sul and Sao Paulo/Parana, dedicated to the pre-filling situation evaluation, facilitated the preventive, corrective or alleviative actions adoption of the possible alterations in the adjacent free aquifers and, consequently, in the land use and occupation, as well as the planning of the rational usage of non-occupied areas in the reservoir margin. It presents the origin, the history and the objectives of the studies as well as the foreseen and confirmed hydrogeological impacts in monitored reservoirs

Aspectos genéticos da SAOS Genetic aspects of obstructive sleep apnea syndrome

Directory of Open Access Journals (Sweden)

Adriane C. Mesquita Petruco

2010-06-01

Full Text Available A fisiopatologia da SAOS é resultante da interação entre fatores genéticos e ambientais. Os mais importantes fatores de risco são obesidade e idade. Outros fatores relevantes são anormalidades craniofaciais, hipotireoidismo, menopausa e uso de álcool e de sedativos. A hereditariedade tem sido relacionada a SAOS pela a associação de SAOS a níveis de HLA, obesidade, síndromes genéticas, etnias, sonolência excessiva, alteração do controle ventilatório, expressão de mediadores inflamatórios, entre outros. Este capítulo aborda a variabilidade genética e fenotípica da doença, demonstrando sua relevância no entendimento da fisiopatologia e na avaliação clínica de SAOS.The physiopathology of obstructive sleep apnea syndrome (OSAS results from the interaction between genetic and environmental factors. The principal risk factors are obesity and age. Other relevant risk factors are craniofacial abnormalities, hypothyroidism and menopause, as well as the use of alcohol and sedatives. By virtue of its association with factors such as HLA levels, obesity, genetic syndromes, ethnicity, excessive sleepiness, alterations in ventilatory control and expression of inflammatory mediators, OSAS has been related to heritability. This chapter addresses the genetic and phenotypic variability of the disease, showing its relevance in the understanding of the physiopathology and clinical evaluation of OSAS.

Rural electrification with multiple actors - the experience of the brazilian state of Sao Paulo

International Nuclear Information System (INIS)

Pazzini, Luiz Henrique Alves; Pelegrini, Marcelo Aparecido; Ribeiro, Fernando Selles; Galvao, Luiz Claudio Ribeiro

1999-01-01

The lack of resources and the new scenery of private utilities turn necessary to look for the ways that allow to illuminate the rural zone. Several international papers show the involvement of different segments of the society as being a viable alternative to execute this goal. This paper analyses the experience of Sao Paulo in the practice of a program of rural electrification in which the society is involved. The model, the operational difficulties and the alternatives made to agile program are appraised. The main conclusion is that, in spite of the difficulties, the model in which the society is included is a viable alternative to solve the subject of the lack of energy in the countryside. (author)

Energy Balance of the Sao Paulo State -1998 Base year 1997; Balanco energetico do Estado de Sao Paulo - 1998. Ano base 1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-07-01

This energy balance of the Sao Paulo State presents the following main topics that can be outstanding: panorama of the energy matrix; supply and demand of energy by source 1983-1997; energy consumption by sector 1983/1997; economic aspects; resources and reserves energy; and balance of the transformation centers 1983/1997.

[Autoshaping of a button-push response and eye movement in human subjects].

Science.gov (United States)

Kimura, H; Fukui, I; Inaki, K

1990-12-01

Two experiments were conducted with human subjects to investigate the similarities and differences between animal and human behaviors under autoshaping procedures. In these experiments, light served as CS, and display on TV served as US. Whether the pushing button response or gazing response to CS could be obtained in human subjects under Pavlovian conditioning procedure was examined. In Experiment 1, uninstructed naive subjects were placed in a room containing a push-button and a TV display. Within the experimental sessions, the push-button was lit for 8 s as CS, and then paired with the display of a soft pornographic program on TV for 10 s. The result indicated that the modeling of pushing button promoted the increase of response probability among the subjects. The trials conducted after the rest period indicated an increase of response probability. In Experiment 2, a 4 cm square translucent panel was lit for 20 s as CS, and then paired with the display of a computer graphic picture on TV for 8 s as US. Some subjects started gazing at the CS for several seconds. These results indicated that some subjects could acquire the gazing response under the autoshaping procedure.

Metabolic mapping of functional activity in human subjects with the [18F]fluorodeoxyglucose technique

International Nuclear Information System (INIS)

Greenberg, J.H.; Reivich, M.; Alavi, A.

1981-01-01

The 2-[ 18 F]fluoro-2-deoxy-D-glucose technique was used to measure regional cerebral glucose utilization by human subjects during functional activation. Normal male volunteers subjected to one or more sensory stimuli exhibited focal increases in glucose metabolism in response to the stimulus. These results demonstrate that the technique is capable of providing functional maps in vivo related to both body region and submodality of sensory information in the human brain

Researcher liability for negligence in human subject research: informed consent and researcher malpractice actions.

Science.gov (United States)

Jansson, Roger L

2003-02-01

Two sets of federal regulations, the "Common Rule" and Food and Drug Administration (FDA) regulations, govern human subject research that is either federally-funded or involves FDA regulated products. These regulations require, inter alia, that: (1) researchers obtain informed consent from human subjects, and (2) that an Institutional Review Board (IRB) independently review and approve the research protocol. Although the federal regulations do not provide an express cause of action against researchers, research subjects should be able to bring informed consent and malpractice actions against researchers by establishing a duty of care and standard of care. Researchers owe human subjects a duty of care analogous to the special relationship between physicians and patients. The federal regulations should provide the minimum standard of care for informed consent in human subject research, and complying with them should be a partial defense. In contrast, expert testimony should establish the standard of care for researcher malpractice, and IRB approval should be a partial defense.

Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects.

Science.gov (United States)

Al-Jenoobi, Fahad Ibrahim; Al-Thukair, Areej A; Alam, Mohd Aftab; Abbas, Fawkeya A; Al-Mohizea, Abdullah M; Alkharfy, Khalid M; Al-Suwayeh, Saleh A

2015-03-01

Effect of Curcuma longa rhizome powder and its ethanolic extract on CYP2D6 and CYP3A4 metabolic activity was investigated in vitro using human liver microsomes and clinically in healthy human subjects. Dextromethorphan (DEX) was used as common probe for CYP2D6 and CYP3A4 enzymes. Metabolic activity of CYP2D6 and CYP3A4 was evaluated through in vitro study; where microsomes were incubated with NADPH in presence and absence of Curcuma extract. In clinical study phase-I, six healthy human subjects received a single dose (30 mg) of DEX syrup, and in phase-II DEX syrup was administered with Curcuma powder. The enzyme CYP2D6 and CYP3A4 mediated O- and N-demethylation of dextromethorphan into dextrorphan (DOR) and 3-methoxymorphinan (3-MM), respectively. Curcuma extract significantly inhibited the formation of DOR and 3-MM, in a dose-dependent and linear fashion. The 100 μg/ml dose of curcuma extract produced highest inhibition, which was about 70 % for DOR and 80 % for 3-MM. Curcuma significantly increases the urine metabolic ratio of DEX/DOR but the change in DEX/3-MM ratio was statistically insignificant. Present findings suggested that curcuma significantly inhibits the activity of CYP2D6 in in vitro as well as in vivo; which indicates that curcuma has potential to interact with CYP2D6 substrates.

34 CFR 75.681 - Protection of human research subjects.

Science.gov (United States)

2010-07-01

... Conditions Must Be Met by a Grantee? Other Requirements for Certain Projects § 75.681 Protection of human research subjects. If a grantee uses a human subject in a research project, the grantee shall protect the person from physical, psychological, or social injury resulting from the project. (Authority: 20 U.S.C...

Trust in health research relationships: accounts of human subjects.

Science.gov (United States)

McDonald, Michael; Townsend, Anne; Cox, Susan M; Paterson, Natasha Damiano; Lafrenière, Darquise

2008-12-01

TRUST IS FUNDAMENTAL in health research, yet there is little empirical evidence that explores the meaning of trust from the perspective of human subjects. The analysis presented here focuses on how human subjects talked about trust in the in-depth interviews. It emerged from the accounts that trust could not be assumed in the research setting, rather it was portrayed as a dynamic concept, built and easily broken, characterized by reciprocity and negotiation. Human subjects were ambivalent about who, when, what, and how much to trust in the research endeavor. This paper adds a fresh perspective to the literature on trust, and so offers a currently neglected, and little understood dimension to the discourse around health research ethics.

Síndrome da apneia obstrutiva do sono (Saos e sonolência diurna excessiva (SDE: influência sobre os riscos e eventos de queda em idosos

Directory of Open Access Journals (Sweden)

Renata Afonso Burgos

Full Text Available INTRODUÇÃO: Muitos países vêm experimentando o processo de envelhecimento populacional e a consequente elevação das doenças associadas a ele, como dificuldade de manter o equilíbrio, perdas na qualidade do sono e síndrome da apneia obstrutiva do sono (Saos. OBJETIVOS:Investigar a correlação entre a Saos e sonolência diurna excessiva (SDE com os riscos e eventos de quedas em indivíduos idosos. MATERIAIS E MÉTODOS:Estudo descritivo, comparativo, de corte transversal com amostra de 75 indivíduos com idade igual ou superior a 60 anos, gêneros masculino e feminino. Foram utilizados o mini-exame do estado mental; escalas de depressão geriátrica simplificada; de sonolência de epworth; de avaliação do equilíbrio de tinneti; índice de massa corporal (IMC; registros estabilométricos das oscilações posturais ântero-posterior (AP e médio-lateral (ML. RESULTADOS: Maior prevalência de Saos no gênero masculino. Não foi encontrada correlação com significância estatística (Pearson, p ≤ 0,01 entre as variáveis IMC e estabilometria. Não houve correlação estatisticamente significativa (ANOVA, p ≤ 0,05 entre IMC (subgrupos normal, sobrepeso, graus I, II, III, e IV e estabilometria; entre os graus de severidade de Saos e estabilometria; entre dados estabilométricos de subgrupos de IMC e mesmo grau de severidade de Saos; entre dados estabilométricos de subgrupos de IMC e diferentes graus de Saos; entre os diferentes graus de Saos (GC, G1, (GC e G2, subgrupos de IMC e registros estabilométricos. CONCLUSÃO: Não foram encontrados resultados que corroborassem a hipótese de proporcionalidade entre graus de severidade de Saos, IMC e registro estabilométrico.

Response of SAOS-2 cells to simulated microgravity and effect of biocompatible sol-gel hybrid coatings

Science.gov (United States)

Catauro, M.; Bollino, F.; Papale, F.

2016-05-01

The health of astronauts, during space flight, is threatened by bone loss induced by microgravity, mainly attributed to an imbalance in the bone remodeling process. In the present work, the response to the microgravity of bone cells has been studied using the SAOS-2 cell line grown under the condition of weightlessness, simulated by means of a Random Positioning Machine (RPM). Cell viability after 72 h of rotation has been evaluated by means of WST-8 assay and compared to that of control cells. Although no significant difference between the two cell groups has been observed in terms of viability, F-actin staining showed that microgravity environment induces cell apoptosis and altered F-actin organization. To investigate the possibility of hindering the trend of the cells towards the death, after 72 h of rotation the cells have been seeded onto biocompatible ZrO2/PCL hybrid coatings, previously obtained using a sol-gel dip coating procedure. WST-8 assay, carried out after 24 h, showed that the materials are able to inhibit the pro-apoptotic effect of microgravity on cells.

Early and late cretaceous magmatism from Sao Sebastiao island (SE-Brazil): geochemistry and petrology

International Nuclear Information System (INIS)

Bellieni, G.; Cavazzini, G.; Montes-Lauar, C.R.; Melfi, A.J.; Pacca, I.G.; De Min, A.; Piccirillo, E.M.

1990-01-01

The Sao Sebastiao island (236 km 2 ), located along the coast of the Sao Paulo State (Southern Brazil), is characterized by precambrian granitic affected by the Brasiliano tectonic-metamorphic cycle. This crystalline basement is intruded by Early Cretaceous (EC) sub alkaline basic and acid dykes, as well as by Late Cretaceous (LC) alkaline stocks (syenites) and dykes (basanite to phonolite). Geochemical, Sr-isotopic and mineral chemistry data point out that: EC-dykes reveal a basic-acid bimodal character, similar to that of the 'coeval' Parana basin flood volcanics; the acid dykes correspond, in composition, to the acid volcanics of the northern Parana basin: the EC-dykes can represent the eastern extension of the inland Santos-Rio de Janeiro dyke swarm, and LC alkaline stocks and dykes constitute distinct groups, characterized by different Sr-isotope initial ratios (syenites: av. 0.7052 and basanites + tephrites = av. 0.7045), which indicate that they are related to different time-integrated mantle source materials. (author)

Transcriptional Regulation of Frizzled-1 in Human Osteoblasts by Sp1.

Directory of Open Access Journals (Sweden)

Shibing Yu

Full Text Available The wingless pathway has a powerful influence on bone metabolism and is a therapeutic target in skeletal disorders. Wingless signaling is mediated in part through the Frizzled (FZD receptor family. FZD transcriptional regulation is poorly understood. Herein we tested the hypothesis that Sp1 plays an important role in the transcriptional regulation of FZD1 expression in osteoblasts and osteoblast mineralization. To test this hypothesis, we conducted FZD1 promoter assays in Saos2 cells with and without Sp1 overexpression. We found that Sp1 significantly up-regulates FZD1 promoter activity in Saos2 cells. Chromatin immunoprecipitation (ChIP and electrophoretic mobility shift (EMSA assays identified a novel and functional Sp1 binding site at -44 to -40 from the translation start site in the FZD1 promoter. The Sp1-dependent activation of the FZD1 promoter was abolished by mithramycin A (MMA, an antibiotic affecting both Sp1 binding and Sp1 protein levels in Saos2 cells. Similarly, down-regulation of Sp1 in hFOB cells resulted in less FZD1 expression and lower alkaline phosphatase activity. Moreover, over-expression of Sp1 increased FZD1 expression and Saos2 cell mineralization while MMA decreased Sp1 and FZD1 expression and Saos2 cell mineralization. Knockdown of FZD1 prior to Sp1 overexpression partially abolished Sp1 stimulation of osteoblast differentiation markers. Taken together, our results suggest that Sp1 plays a role in human osteoblast differentiation and mineralization, which is at least partially mediated by Sp1-dependent transactivation of FZD1.

Ethical fundamentals in human subjects research : On equipoise and human dignity

NARCIS (Netherlands)

van der Graaf - Verhave, R.

2010-01-01

In her PhD thesis Rieke van der Graaf has studied how we can ethically justify human subjects research. In particular she has studied two ethical fundamentals that play a key role in the justification process, that of equipoise and human dignity. Equipoise is often taken to mean that

Agriculture, Rio Sao Francisco, Brazil, South America

Science.gov (United States)

1988-01-01

The large field patterns in this view of the Rio Sao Francisco basin, Brazil, South America, (11.5S, 43.5W) indicate a commercial agriculture venture; family subsistence farms are much smaller and laid out in different patterns. Land clearing in Brazil has increased at an alarming rate in recent years and preliminary estimates suggest a 25 to 30% increase in deforestation since 1984. The long term impact on the ecological processes are still unknown.

Potential of municipal solid waste (MSW) as a source of energy in Sao Paulo: its impact on CO2 balance

International Nuclear Information System (INIS)

Leao, A.L.; Ing Hwie Tan

1998-01-01

Energy generation is needed in Sao Paulo and MSW represents a promising alternative, although it is more expensive than hydroelectric power. About 14 900 t/day of MSW is generated, of which 8433 t/day is domestic and commercial MSW. From this amount, 1800 t will be destined to generate 30 MW of power. The eco-balance of CO 2 has been considered for incineration and recycling. The recycling program of plastics, metals, paper and glass would represent a significant reduction in energy and CO 2 emission. The total CO 2 released is 3.34 x 10 5 t/yr without recycling, and is 1.25 x 10 5 t/yr with a recycling program. Most of the CO 2 comes from plastics and paper production. Economic aspects could probably favor incineration with energy production as the best option. (author)

Insulin resistance in human subjects having impaired glucose regulation

International Nuclear Information System (INIS)

Khan, S.H.; Khan, F.A.; Ijaz, A.

2007-01-01

To determine insulin resistance in human subjects having impaired glucose regulation (IGR) by Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). A total of 100 subjects with impaired glucose regulation were selected for evaluation of metabolic syndrome as per the criteria of National Cholesterol Education Program, Adult Treatment Panel III (NCEP, ATP III), along with 47 healthy age and gender-matched controls. Physical examination to determine blood pressure and waist circumference was carried out and so was sampling for plasma glucose, serum triglycerides, HDL-cholesterol and insulin. Insulin resistance was calculated by the HOMA-IR. Finally, subjects with and without metabolic syndrome were compared with controls (n=47), using one-way ANOVA for studying insulin resistance between groups, with Tukey's post-hoc comparison. The frequency of finding metabolic syndrome in cases of IGR remained 47%. The insulin resistance demonstrated stepwise worsening from control population (mean=1.54, 95 % CI: 1.77 - 2.37) to subjects suffering from only IGR (mean=2.07, 95 % CI: 1.77- 2.37) to metabolic syndrome (mean=2.67, 95 %, CI: 2.34 - 3.00) (p < 0.001). Patients with impaired glucose regulation may have significant insulin resistance. It is, thus, recommended that a vigorous search be made to measure insulin resistance in all cases diagnosed to have impaired glucose regulation. (author)

FA1 Induces Pro-Inflammatory and Anti-Adipogenic Pathways/Markers in Human Myotubes Established from Lean, Obese, and Type 2 Diabetic Subjects but Not Insulin Resistance

DEFF Research Database (Denmark)

Abdallah, Basem M; Beck-Nielsen, Henning; Gaster, Michael

2013-01-01

Aims: Delta like 1/fetal antigen 1 (Dlk1/FA1) is a protein secreted by hormone producing cells in adult human and mice that is known to inhibit adipogenesis. Recent studies demonstrated the role of Dlk1/FA1 in inducing insulin resistance in mice. To investigate the involvement of circulating Dlk1....../FA1 in insulin resistance and type 2 diabetes in human subjects, we studied the effects of chronic FA1 on the intermediary metabolism in myotubes established from lean, obese, and type 2 diabetic (T2D) subjects. Methods: Myotube cultures were established from lean and obese control subjects......, and obese T2D subjects and treated with soluble FA1 for 4 days supplemented with/without palmitate (PA). Lipid- and glucose metabolism were studied with labeled precursors while quantitative expression of genes was analyzed using real-time PCR. Results: Diabetic myotubes express significantly reduced...

Investigating the provenance of iron artifacts of the Royal Iron Factory of Sao Joao de Ipanema by hierarchical cluster analysis of EDS microanalyses of slag inclusions

Energy Technology Data Exchange (ETDEWEB)

Mamani-Calcina, Elmer Antonio; Landgraf, Fernando Jose Gomes; Azevedo, Cesar Roberto de Farias, E-mail: c.azevedo@usp.br [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Escola Politecnica. Departmento de Engenharia Metalurgica e de Materiais

2017-01-15

Microstructural characterization techniques, including EDX (Energy Dispersive X-ray Analysis) microanalyses, were used to investigate the slag inclusions in the microstructure of ferrous artifacts of the Royal Iron Factory of Sao Joao de Ipanema (first steel plant of Brazil, XIX century), the D. Pedro II Bridge (located in Bahia, assembled in XIX century and produced in Scotland) and the archaeological sites of Sao Miguel de Missoes (Rio Grande do Sul, Brazil, production site of iron artifacts, the XVIII century) and Afonso Sardinha (Sao Paulo, Brazil production site of iron artifacts, XVI century). The microanalyses results of the main micro constituents of the microstructure of the slag inclusions were investigated by hierarchical cluster analysis and the dendrogram with the microanalyses results of the wüstite phase (using as critical variables the contents of MnO, MgO, Al{sub 2}O{sub 3}, V{sub 2}O{sub 5} and TiO{sub 2}) allowed the identification of four clusters, which successfully represented the samples of the four investigated sites (Ipanema, Sardinha, Missoes and Bahia). Finally, the comparatively low volumetric fraction of slag inclusions in the samples of Ipanema (∼1%) suggested the existence of technological expertise at the iron making processing in the Royal Iron Factory of Sao Joao de Ipanema. (author)

U, TH and lanthanides in street soils of Sao Paulo city, Brazil

International Nuclear Information System (INIS)

Ticianelli, R.B.; Ribeiro, A.P.; Figueiredo, A.M.G.; Zanh, G.S.

2013-01-01

The study of lanthanide distribution in urban environments has become of interest over the last years, due to the increased industrial use of these elements. Sao Paulo is the 6th largest metropolitan region of the world, with about 20 million inhabitants in its metropolitan area, more than 9 million motor vehicles and intense industrial activity. There is little information on U, Th, and lanthanide contents in urban soils, and there are as of yet no reference values for these elements in soils of Sao Paulo city. The present study aimed to determine U, Th and lanthanide concentrations in soils adjacent to avenues of highly dense traffic downtown in Sao Paulo city, to assess their possible sources and potential environmental impacts. The analytical technique employed was Instrumental Neutron Activation Analysis (INAA). Th and U levels ranged from 4.0 to 37.0 mg kg -1 and from 1.6 to 18.7 mg kg -1 , respectively. These values are higher than literature values for U and Th in Brazilian superficial soils. The results obtained for the lanthanides indicate enrichment in La and Ce. However, a possible anthropogenic source should be investigated since high background values of these elements may be associated to the natural geological composition of the soils. (author)

Financing structure for the hydroelectric sector: the Companhia Energetica de Sao Paulo - CESP case; Estrutura de financiamento do setor hidreletrico: o caso da CESP

Energy Technology Data Exchange (ETDEWEB)

Leme, Thomaz Garcez

1987-12-31

The objective of this dissertation is to study the financial resources made use by Companhia Energetica de Sao Paulo - CESP - for its implantation and later expansion, during the period of 1967 to 1980. The motivation in developing this subject originated of CESP`s importance in the Brazilian electric power sector. The dissertation is divided into three chapters. The first chapter describes the power sector in the state of Sao Paulo before CESP`s creation and after its consolidation. The second chapter studies some matter that shows the importance of company in the Brazilian power sector. In the third chapter, we study the performance of own resources and the third resources in CESP`s financing. At the end of the study the most important conclusion is that the own resources, more than third resources, were the prime motive liable in CESP`s financing during the period. (author) 102 refs., 23 figs.

Financing structure for the hydroelectric sector: the Companhia Energetica de Sao Paulo - CESP case; Estrutura de financiamento do setor hidreletrico: o caso da CESP

Energy Technology Data Exchange (ETDEWEB)

Leme, Thomaz Garcez

1988-12-31

The objective of this dissertation is to study the financial resources made use by Companhia Energetica de Sao Paulo - CESP - for its implantation and later expansion, during the period of 1967 to 1980. The motivation in developing this subject originated of CESP`s importance in the Brazilian electric power sector. The dissertation is divided into three chapters. The first chapter describes the power sector in the state of Sao Paulo before CESP`s creation and after its consolidation. The second chapter studies some matter that shows the importance of company in the Brazilian power sector. In the third chapter, we study the performance of own resources and the third resources in CESP`s financing. At the end of the study the most important conclusion is that the own resources, more than third resources, were the prime motive liable in CESP`s financing during the period. (author) 102 refs., 23 figs.

Demand of radiopharmaceutical Fluoride 18-FDG (fluorodeoxyglucose) in the Sao Paulo State metropolitan area

International Nuclear Information System (INIS)

Sato, Renato C.; Zouain, Desiree M.

2005-01-01

This research presents partial results from the development of a Masters Dissertation for the Post-Graduation in Nuclear Technology Program - IPEN/USP, aiming to study the demand of radiopharmaceutical Fluoride 18-FDG (fluorodeoxyglucose) in the Sao Paulo State metropolitan area, as a subsidiary for the establishment of distribution strategy within the State. This study presented the results of a bibliographic review as well as the market evolution for FDG in Sao Paulo. Studies pointed to a tendency of an increase in the international and national nuclear medicine market; while the United States of America participate in 47% of the world profit, South America shares only 2.5% of the global market. This market will tend to grow in 2006 to 2020 up to 776% for diagnosis and 760% for therapy. Partial results are presented in this study from researching medical centers that use PET in the city of Sao Paulo, as well as companies that commercialize the equipment and the manufacturer center. There is an increase of sales for IPEN's Fluoride 18-FDG and its representation on the total radiopharmaceutical profit surpassed 5.3% in 2003 to 8.2% in 2004. The dissemination of this technology in Brazil is lately being discussed especially due to the acquisition price of the equipment as well as the viability of the resources (Fluoride 18- FDG; implementation strategies of regional cyclotron accelerators) and the question of remuneration of the PET produced exams for health care plans and national health care system (SUS). IPEN is developing yet another study to grasp possible demand for this product in the Southern and Southeastern regions, allowing better view of the necessity of the supplement, and in study the implementation of a new cyclotron in the institute dedicated for the production of Fluoride 18-FDG. (author)

Shaded Relief of Rio Sao Francisco, Brazil

Science.gov (United States)

2000-01-01

This topographic image acquired by SRTM shows an area south of the Sao Francisco River in Brazil. The scrub forest terrain shows relief of about 400 meters (1300 feet). Areas such as these are difficult to map by traditional methods because of frequent cloud cover and local inaccessibility. This region has little topographic relief, but even subtle changes in topography have far-reaching effects on regional ecosystems. The image covers an area of 57 km x 79 km and represents one quarter of the 225 km SRTM swath. Colors range from dark blue at water level to white and brown at hill tops. The terrain features that are clearly visible in this image include tributaries of the Sao Francisco, the dark-blue branch-like features visible from top right to bottom left, and on the left edge of the image, and hills rising up from the valley floor. The San Francisco River is a major source of water for irrigation and hydroelectric power. Mapping such regions will allow scientists to better understand the relationships between flooding cycles, forestation and human influences on ecosystems.This shaded relief image was generated using topographic data from the Shuttle Radar Topography Mission. A computer-generated artificial light source illuminates the elevation data to produce a pattern of light and shadows. Slopes facing the light appear bright, while those facing away are shaded. On flatter surfaces, the pattern of light and shadows can reveal subtle features in the terrain. Shaded relief maps are commonly used in applications such as geologic mapping and land use planning.The Shuttle Radar Topography Mission (SRTM), launched on February 11, 2000, uses the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. The mission is designed to collect three-dimensional measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter-long (200

Location study of thermoelectric in Sao Paulo's State, Brazil

International Nuclear Information System (INIS)

Fadigas, Eliane Aparecida F.A.; Reis, Lineu Belico dos

1999-01-01

The article presents the results of studies developed to identify, locate and order thermoelectric generation options through costs increasing. This evaluation considered just options of Sao Paulo, a Brazilian state. The used methodology and the main parameters and variables which influence in the projects economic activity are introduced in the article. A software denominated SAEGET was also used

Environmental radioactive monitoring in Itu, Sao Paulo, Brazil

International Nuclear Information System (INIS)

1990-01-01

The results of the environmental monitoring of a region near to a radioactive materials deposit in Sao Paulo State, Brazil, are presented. The radioactive materials are uranium and thorium hydroxides from monazite processing. The temporal variation of 226 Ra was determined in the superficial and underground water, showing no increase for the former and a maximum concentration of 0,306 Bq/L for the latter. 21 figs., 17 tabs

Prevalence and populations of Listeria monocytogenes in meat products retailed in Sao Paulo, Brazil.

Science.gov (United States)

Ristori, Christiane Asturiano; Rowlands, Ruth Estela Gravato; Martins, Cecília Geraldes; Barbosa, Maria Luisa; Yoshida, Júlia T U; Franco, Bernadette D G de Melo

2014-12-01

This study evaluated the prevalence of the populations and serotypes of Listeria monocytogenes in 552 refrigerated samples of ground beef, chicken leg, hot dog, and pork sausage collected in supermarkets in the city of Sao Paulo, SP, Brazil, between May 2008 and July 2009. The supermarkets were selected after stratification by geographical region and by random draw. Tests for presence and enumeration of L. monocytogenes were based on ISO 11290-1:1996/Amd.1:2004 and ISO 11290-2:1998 methods, respectively. Listeria spp. were detected in 469 (85.0%) of the studied meat products. The most frequently isolated species was L. innocua (64.1%), followed by L. monocytogenes (48.7%), L. welshimeri (13.4%), L. seeligeri (7.1%), L. ivanovii (0.2%), and L. grayi subspecies murrayi (0.2%). L. monocytogenes was detected in 269 (48.7%) samples, with highest prevalence in ground beef (59.4%) followed by chicken legs (58.0%), pork sausages (39.8%), and hot dogs (37.7%). The populations were Prevalence of serotypes varied according to the type of meat product. These data are relevant for estimating the risks of listeriosis associated with consumption of meat products in Sao Paulo, and for establishing science-based intervention strategies aimed at reducing these risks, especially for pregnant women and immunocompromised individuals.

In vitro analysis of low-level laser irradiation on human osteoblast-like cells proliferation

Science.gov (United States)

Bloise, Nora; Saino, Enrica; Bragheri, Francesca; Minzioni, Paolo; Cristiani, Ilaria; Imbriani, Marcello; Visai, Livia

2011-07-01

The objective of this study was to examine the in vitro effect of a single or a multiple doses of low-level laser irradiation (LLLI) on proliferation of the human osteosarcoma cell line, SAOS-2. SAOS-2 cells were divided in five groups and exposed to LLLI (659 nm diode laser; 11 mW power output): group I as a control (dark), group II exposed to a single laser dose of 1 J/cm2, group III irradiated with a single dose of 3 J/cm2, and group IV and V exposed for three consecutive days to 1 or 3 J/cm², respectively. Cellular proliferation was assessed daily up to 7 days of culturing. The obtained results showed an increase in proliferative capacity of SAOS-2 cells during the first 96 h of culturing time in once-irradiated cells, as compared to control cells. Furthermore, a significantly higher proliferation in the group IV and V was detected if compared to a single dose or to control group after 96 h and 7 days. In conclusion, the effect of the single dose on cell proliferation was transitory and repeated irradiations were necessary to observe a strong enhancement of SAOS-2 growth. As a future perspective, we would like to determine the potential of LLLI as a new approach for promoting bone regeneration onto biomaterials.

Hyperthermia effects in the presence of gold nanoparticles together with chemotherapy on Saos-2 cell line

International Nuclear Information System (INIS)

Sazgarnia, A.; Bahreyni Toosi, M. H.; Haji Ghahremani, F.; Rajabi, O.; Aledavood, A.; Esmaily, H.

2011-01-01

Hyperthermia created by microwave, infrared, ultrasound and other methods, is often utilized as an adjuvant to sensitize cancer cells to the effects of chemotherapy and radiation therapy. We investigated the efficacy of hyperthermia using microwave in synergy with chemotherapy in the presence and absence and gold nanoparticles. Material and Methods: After culturing and proliferation of the Saos-2 cell line derived from human osteogenic sarcoma, the cells were incubated at two concentrations of gold nanoparticles in two diameters of 20 and 40 nm and in the absence and presence of doxorubicin in different groups. Forty eight hours after irradiating the cells with microwave up to a temperature of 42 d egree C , cell survival rate was determined using the MTT method, in order to study the effectiveness of the therapeutic parameters. Results: Cell survival in the presence of gold nanoparticles was greater than 95%. After chemotherapy by doxorubicin with and without 40 nm gold nanoparticles, cell survival rates were determined as 62.8% and 37.1 %, declining down to 17% and 4.1% respectively following the combined treatment with microwave and chemotherapy in the presence of 20 and 40 nm gold nanoparticles. Discussion and Conclusions: Gold nanoparticles did not induce any cytotoxicity by themselves; their presence along with microwave provided a reduction in survival rate that was comparable in severity with the lethal effects of doxorubicin. microwave hyperthermia with gold nanoparticles produced a higher treatment efficiency in comparison to similar groups in which gold nanoparticles were absent. The synergism observed between hyperthermia and chemotherapy was dependent in gold nanoparticles' size and concentration. This finding could be caused by increased uptake of doxorubicin by the cells in the presence of gold nanoparticles.

GiSAO.db: a database for ageing research

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Grillari Johannes

2011-05-01

Full Text Available Abstract Background Age-related gene expression patterns of Homo sapiens as well as of model organisms such as Mus musculus, Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster are a basis for understanding the genetic mechanisms of ageing. For an effective analysis and interpretation of expression profiles it is necessary to store and manage huge amounts of data in an organized way, so that these data can be accessed and processed easily. Description GiSAO.db (Genes involved in senescence, apoptosis and oxidative stress database is a web-based database system for storing and retrieving ageing-related experimental data. Expression data of genes and miRNAs, annotation data like gene identifiers and GO terms, orthologs data and data of follow-up experiments are stored in the database. A user-friendly web application provides access to the stored data. KEGG pathways were incorporated and links to external databases augment the information in GiSAO.db. Search functions facilitate retrieval of data which can also be exported for further processing. Conclusions We have developed a centralized database that is very well suited for the management of data for ageing research. The database can be accessed at https://gisao.genome.tugraz.at and all the stored data can be viewed with a guest account.

Synthesis, characterization and anti cancer activity of some fluorinated 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

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Deepak Chowrasia

2017-05-01

Full Text Available A series of fluorinated 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (2a–2i was synthesized by condensation of various substituted 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiols (1a–1i with penta fluoro benzoic acid in good yields (60–80%. The synthesized compounds were screened for anticancer activity against three cancerous cell lines MCF7 (human breast cancer, SaOS-2 (human osteosarcoma and K562 (human myeloid leukemia. The compounds showed moderate to good antiproliferative potency against the studied cell lines. Among these, compound 2b showed higher antiproliferative activity (IC50 22.1, 19 and 15 μM against MCF7, SaOS-2 and K562, respectively while 2a exhibited least antiproliferative activity (IC50 30.2, 39 and 29.4 μM against MCF7, SaOS-2 and K562 cells, respectively. Therefore, the present study demonstrates that fluorine substituted 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles would be a better prospective in the development of anticancer drugs.

Impaired STING Pathway in Human Osteosarcoma U2OS Cells Contributes to the Growth of ICP0-Null Mutant Herpes Simplex Virus.

Science.gov (United States)

Deschamps, Thibaut; Kalamvoki, Maria

2017-05-01

Human herpes simplex virus 1 (HSV-1) is a widespread pathogen, with 80% of the population being latently infected. To successfully evade the host, the virus has evolved strategies to counteract antiviral responses, including the gene-silencing and innate immunity machineries. The immediately early protein of the virus, infected cell protein 0 (ICP0), plays a central role in these processes. ICP0 blocks innate immunity, and one mechanism is by degrading hostile factors with its intrinsic E3 ligase activity. ICP0 also functions as a promiscuous transactivator, and it blocks repressor complexes to enable viral gene transcription. For these reasons, the growth of a ΔICP0 virus is impaired in most cells, except cells of the human osteosarcoma cell line U2OS, and it is only partially impaired in cells of the human osteosarcoma cell line Saos-2. We found that the two human osteosarcoma cell lines that supported the growth of the ΔICP0 virus failed to activate innate immune responses upon treatment with 2'3'-cyclic GAMP (2'3'-cGAMP), the natural agonist of STING (i.e., stimulator of interferon genes) or after infection with the ΔICP0 mutant virus. Innate immune responses were restored in these cells by transient expression of the STING protein but not after overexpression of interferon-inducible protein 16 (IFI16). Restoration of STING expression resulted in suppression of ΔICP0 virus gene expression and a decrease in viral yields. Overexpression of IFI16 also suppressed ΔICP0 virus gene expression, albeit to a lesser extent than STING. These data suggest that the susceptibility of U2OS and Saos-2 cells to the ΔICP0 HSV-1 is in part due to an impaired STING pathway. IMPORTANCE The DNA sensor STING plays pivotal role in controlling HSV-1 infection both in cell culture and in mice. The HSV-1 genome encodes numerous proteins that are dedicated to combat host antiviral responses. The immediate early protein of the virus ICP0 plays major role in this process as it targets

Determination of natural radioactivity in public water supplies of Sao Paulo State. V.1-2

International Nuclear Information System (INIS)

Oliveira, Joselene de

1998-01-01

This study aimed to determine the activity concentrations of natural occurring radionuclides of the 238 U and 232 Th series in drinking water supplies of Sao Paulo State. A sampling program was carried out, in order to perform this survey, starting in 1994 and covering 54% of the 574 existing counties. The locations studied correspond to the public water systems operated routinely by SABESP - Companhia de Saneamento Basico do Estado de Sao Paulo, which is the state company responsible for collecting, treating and supplying water. The activity concentrations of 226 Ra and 228 Ra were determined by gross alpha and beta counting, respectively, of a Ba(Ra)SO 4 precipitate in a low-background gasflow proportional counter. The 228 Rn concentrations were determined by liquid scintillation method. Concentrations up to 235 mBq/L and 131 mBq/L were observed for 226 Rn and 228 Ra, respectively, whereas 222 Rn concentrations reached 315 Bq/L. Of the 452 water samples analyzed, a total of 3 presented activity concentrations for 226 Ra above the limit of 0.1 Bq/L adopted by the Brazilian regulation for the gross-alpha activity in drinking water. These results, however, are below 1/50 of the annual limit of intake recommended for 226 Ra by 'Comissao Nacional de Energia Nuclear', if an ingestion rate of 2L/d per person is considered. For the gross-beta activity, all the measured samples presented 228 Ra activity concentrations below 1 Bq/L. It is concluded that the consumption of such waters will not imply in any additional health risk to the population. In order to evaluate the radioactive doses due to the ingestion of these waters, a conservative dosimetric calculation was carried out using dose conversion factors suggested by ICRP (International Commission on Radiological Protection). Doses up to 0.3 mSv/y, 0.6 mSv/y and 3.2 mSv/y were estimated for the critical organs, for the ingestion of 226 Ra, 228 Ra and 222 Rn, respectively; while the corresponding committed effective

New aerosol particles formation in the Sao Paulo Metropolitan Area

Science.gov (United States)

Vela, Angel; Andrade, Maria de Fatima; Ynoue, Rita

2016-04-01

The Sao Paulo Metropolitan Area (SPMA), in the southeast region of Brazil, is considered a megalopolis comprised of Sao Paulo city and more 38 municipalities. The air pollutant emissions in the SPMA are related to the burning of the fuels: etanol, gasohol (gasoline with 25% ethanol) and diesel. According to CETESB (2013), the road vehicles contributed up to about 97, 87, and 80% of CO, VOCs and NOx emissions in 2012, respectively, being most of NOx associated to diesel combustion and most of CO and VOCs from gasohol and ethanol combustion. Studies conducted on ambient air pollution in the SPMA have shown that black carbon (BC) explains 21% of mass concentration of PM2.5 compared with 40% of organic carbon (OC), 20% of sulfates, and 12% of soil dust (Andrade et al., 2012). Most of the observed ambient PM2.5 mass concentration usually originates from precursors gases such as sulphur dioxide (SO2), ammonia (NH3), nitrogen oxides (NOx) and VOCs as well as through the physico-chemical processes such as the oxidation of low volatile hydrocarbons transferring to the condensed phase (McMurry et al., 2004). The Weather Research and Forecasting with Chemistry model (WRF-Chem; Grell et al. 2005), configured with three nested grid cells: 75, 15, and 3 km, is used as photochemical modeling to describe the physico-chemical processes leading to evolution of particles number and mass size distribution from a vehicular emission model developed by the IAG-USP laboratory of Atmospheric Processes and based on statistical information of vehicular activity. The spatial and temporal distributions of emissions in the finest grid cell are based on road density products compiled by the OpenStreetMap project and measurements performed inside tunnels in the SPMA, respectively. WRF-Chem simulation with coupled primary aerosol (dust and sea-salt) and biogenic emission modules and aerosol radiative effects turned on is conducted as the baseline simulation (Case_0) to evaluate the model

Sao Paulo Lightning Mapping Array (SP-LMA): Deployment and Plans

Science.gov (United States)

Bailey, J. C.; Carey, L. D.; Blakeslee, R. J.; Albrecht, R.; Morales, C. A.; Pinto, O., Jr.

2011-01-01

An 8-10 station Lightning Mapping Array (LMA) network is being deployed in the vicinity of Sao Paulo to create the SP-LMA for total lightning measurements in association with the international CHUVA [Cloud processes of tHe main precipitation systems in Brazil: A contribUtion to cloud resolVing modeling and to the GPM (GlobAl Precipitation Measurement)] field campaign. Besides supporting CHUVA science/mission objectives and the Sao Luz Paraitinga intensive operation period (IOP) in December 2011-January 2012, the SP-LMA will support the generation of unique proxy data for the Geostationary Lightning Mapper (GLM) and Advanced Baseline Imager (ABI), both sensors on the NOAA Geostationary Operational Environmental Satellite-R (GOES-R), presently under development and scheduled for a 2015 launch. The proxy data will be used to develop and validate operational algorithms so that they will be ready for use on "day1" following the launch of GOES-R. A preliminary survey of potential sites in the vicinity of Sao Paulo was conducted in December 2009 and January 2010, followed up by a detailed survey in July 2010, with initial network deployment scheduled for October 2010. However, due to a delay in the Sa Luz Paraitinga IOP, the SP-LMA will now be installed in July 2011 and operated for one year. Spacing between stations is on the order of 15-30 km, with the network "diameter" being on the order of 30-40 km, which provides good 3-D lightning mapping 150 km from the network center. Optionally, 1-3 additional stations may be deployed in the vicinity of Sa Jos dos Campos.

Subjective dimension in the analysis of human development

Directory of Open Access Journals (Sweden)

LÓPEZ NOVAL, Borja

2012-06-01

Full Text Available In recent years subjective evaluations about own quality of life, resumed in levels of life satisfactionor happiness, are gaining importance as indicators of development. Some authors state that subjectivewell-being is a necessary and sufficient condition for human development. In this work the arguments ofthese authors are explained and it is discussed the role subjective evaluations must play on developmentstudies. The main conclusion is that although it is necessary to integrate subjective well-being into humandevelopment studies we cannot identify subjective well-being and development.

Pb-210 deposition measured in rainfall in Sao Paulo, SP-Brazil

Energy Technology Data Exchange (ETDEWEB)

Damatto, Sandra R.; Frujuele, Jonatan V.; Souza, Joseilton M.; Santos, Levi F., E-mail: damatto@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Lab. de Radiometria Ambiental

2013-07-01

Pb-210 (T{sub 1/2} = 22.3 y), a natural radionuclide from U-238 serie can be found in the atmosphere, as a product of {sup 222}Rn decay that emanates from the ground, where its atoms become rapidly fixed to aerosols and return to the earth as dry fallout or are washed out in the rain. This natural radionuclide has been widely used as an atmospheric tracer, to determine the aerosol residence time as well as chronometers in the environment. Pb-210 was measured during a period of two years, 2011 to 2013, in samples of rainfall in all the rainy events that occurred at the Instituto de Pesquisas Energeticas e Nucleares (IPEN) campus (23 deg 33’59.24” S - 46 deg 44’15.63” O at 760 m above sea level) which is located in the city of Sao Paulo, in the state of Sao Paulo, Brazil. Pb-210 concentration was measured in a total of 123 rainy events by beta gross counting in a low background gas flow proportional detector, after radiochemistry procedure. The results obtained were correlated to seasons and rainfall. The concentrations of {sup 210}Pb in rainfall varied from the minimum detectable activity, 4.9 mBq L{sup -1} to 1408± 43 mBq L{sup -1}. The highest concentrations were obtained in the months of winter and the lowest in summer. The monthly depositional flux of {sup 210}Pb, varied from 4.03 Bq m{sup -2} month{sup -1} to 46.4 Bq m{sup -2} month{sup -1}presenting a strong correlation with the amount of precipitation and hence showing seasonal trends. (author)

Metal and trace element assessment of sediments from Guarapiranga reservoir, Sao Paulo State, by neutron activation analysis

International Nuclear Information System (INIS)

Guimaraes, Guilherme M.; Favaro, Deborah I.T.; Franklin, Robson L.; Ferreira, Francisco J.; Bevilacqua, Jose E.

2009-01-01

Guarapiranga Reservoir is extremely important due to the fact that it is one of the main water reservoirs for South America's largest city, Sao Paulo, Brazil. Guarapiranga Basin is located within the Metropolitan Region of Sao Paulo - RMSP, and occupies an area of approximately 630 km 2 , and the reservoir itself is located in the northern part of the basin occupying approximately 26 km 2 . This reservoir is characterized by environmental impacts from urban invasion, industrial and sewage wastes, all of which seriously affect its water quality. Due to its vulnerability CETESB (Environmental Control Agency of the Sao Paulo State) regularly monitors the contamination levels of waters and once a year sediment samples. In order to better understand geochemical and environmental processes and their possible changes due to anthropogenic activities trace metals analyses and their distribution in sediments are commonly undertaken. The present study reports results concerning the distribution of some major (Fe, K and Na), trace (As, Ba, Br, Co, Cr, Cs, Hf, Hg, Rb, Sb, Sc, Ta, Tb, Th, U and Zn) and rare earth (Ce, Eu, La, Lu, Nd, Sm, Tb and Yb) elements in sediments from the Guarapiranga Reservoir. Multielementar analysis was carried out by instrumental neutron activation analysis (INAA). Multielemental concentrations in the sediment samples were compared to NASC (North American Shale Composite) values. The concentration values for metals As, Cr and Zn in the sediment samples were compared to the Canadian Council of Minister of the Environment (CCME) oriented values (TEL and PEL values) and adopted by CETESB. (author)

Vanglaülestõus vallandas Sao Paulos kaose / Erik Henno

Index Scriptorium Estoniae

Henno, Erik

2006-01-01

11. mail vallandus Sao Paulo vanglates konflikt, mis laienes üle osariigi ning mille käigus süüdati kümneid busse, rünnati politseiautosid ja pangakontoreid, pantvangi võeti ligi 200 inimest. Kaubanduskeskused ja koolid jäid suletuks, ühistransport oli halvatud. Kaart: Vägivallalaine Brasiilias. Lisa: Maffia

Cholesterol Metabolism and Weight Reduction in Subjects with Mild Obstructive Sleep Apnoea: A Randomised, Controlled Study

Directory of Open Access Journals (Sweden)

Maarit Hallikainen

2013-01-01

Full Text Available To evaluate whether parameters of obstructive sleep apnoea (OSA associate with cholesterol metabolism before and after weight reduction, 42 middle-aged overweight subjects with mild OSA were randomised to intensive lifestyle intervention (N=23 or to control group (N=18 with routine lifestyle counselling only. Cholesterol metabolism was evaluated with serum noncholesterol sterol ratios to cholesterol, surrogate markers of cholesterol absorption (cholestanol and plant sterols and synthesis (cholestenol, desmosterol, and lathosterol at baseline and after 1-year intervention. At baseline, arterial oxygen saturation (SaO2 was associated with serum campesterol (P<0.05 and inversely with desmosterol ratios (P<0.001 independently of gender, BMI, and homeostasis model assessment index of insulin resistance (HOMA-IR. Apnoea-hypopnoea index (AHI was not associated with cholesterol metabolism. Weight reduction significantly increased SaO2and serum cholestanol and decreased AHI and serum cholestenol ratios. In the groups combined, the changes in AHI were inversely associated with changes of cholestanol and positively with cholestenol ratios independent of gender and the changes of BMI and HOMA-IR (P<0.05. In conclusion, mild OSA seemed to be associated with cholesterol metabolism independent of BMI and HOMA-IR. Weight reduction increased the markers of cholesterol absorption and decreased those of cholesterol synthesis in the overweight subjects with mild OSA.

An Einstein Observatory SAO-based catalog of B-type stars

Science.gov (United States)

Grillo, F.; Sciortino, S.; Micela, G.; Vaiana, G. S.; Harnden, F. R., Jr.

1992-01-01

About 4000 X-ray images obtained with the Einstein Observatory are used to measure the 0.16-4.0 keV emission from 1545 B-type SAO stars falling in the about 10 percent of the sky surveyed with the IPC. Seventy-four detected X-ray sources with B-type stars are identified, and it is estimated that no more than 15 can be misidentified. Upper limits to the X-ray emission of the remaining stars are presented. In addition to summarizing the X-ray measurements and giving other relevant optical data, the present extensive catalog discusses the reduction process and analyzes selection effects associated with both SAO catalog completeness and IPC target selection procedures. It is concluded that X-ray emission, at the level of Lx not less than 10 exp 30 ergs/s, is quite common in B stars of early spectral types (B0-B3), regardless of luminosity class, but that emission, at the same level, becomes less common, or nonexistent, in later B-type stars.

Protecting human research subjects: the past defines the future.

Science.gov (United States)

Breault, Joseph L

2006-01-01

The creation of Institutional Review Boards to assure the protection of research subjects came out of terrible research abuses that resulted in the Belmont Report and federal regulations establishing rules for federally funded research and its independent review. The Common Rule became widely accepted as the way to oversee human research that is funded by federal agencies, or used in FDA submissions. The Office of Human Research Protections, now under the Secretary of DHHS, created Federalwide Assurances with groups that receive federal funding and others, the vast majority of which have agreed to apply the same ethical rules to all research regardless of funding source. There are controversies over the best methods to protect human research subjects, confusion about how to handle some of the gray areas, increased regulatory burdens, and debates about the adequacy of the IRB system. New exciting directions have evolved and overall, research subjects appear better protected than ever.

Hospitalization flow in the public and private systems in the state of Sao Paulo, Brazil.

Science.gov (United States)

Rocha, Juan Stuardo Yazlle; Monteiro, Rosane Aparecida; Moreira, Marizélia Leão

2015-01-01

OBJECTIVE To describe the migration flows of demand for public and private hospital care among the health regions of the state of Sao Paulo, Brazil.METHODS Study based on a database of hospitalizations in the public and private systems of the state of Sao Paulo, Southeastern Brazil, in 2006. We analyzed data from 17 health regions of the state, considering people hospitalized in their own health region and those who migrated outwards (emigration) or came from other regions (immigration). The index of migration effectiveness of patients from both systems was estimated. The coverage (hospitalization coefficient) was analyzed in relation to the number of inpatient beds per population and the indexes of migration effectiveness.RESULTS The index of migration effectiveness applied to the hospital care demand flow allowed characterizing health regions with flow balance, with high emigration of public and private patients, and with high attraction of public and private patients.CONCLUSIONS There are differences in hospital care access and opportunities among health regions in the state of Sao Paulo, Brazil.

[Urban and rural population of the state of Sao Paulo: results of the census of 1980].

Science.gov (United States)

Saad, P M

1981-01-01

The accelerated urban growth of Sao Paulo between 1940-70 has continued during the period 1970-80, according to the 1980 censes. During 1970-80 the urban population increased 55.47%, while the rural population decreased 18.67%, bringing the percentage of the urban population to 88.6% of the total population of the state. This phenomenon has been common to all the 11 administrative regions of the state. The highest percentage of the urban population in 1980 was in the region of Greater Sao Paulo, followed by Litoral and Vale do Paraiba. The largest increases in urban population were in the regions of Sorocaba, Campinas, and Vale do Paraiba, while the highest decreases in rural population were in the regions of Sao Jose do Rio Preto, Aracatuba, Presidente Prudente, and Marilia. The document presents detailed data for each of the 11 administrative regions of the state, and for each municipality within a region.

A Subject-Specific Kinematic Model to Predict Human Motion in Exoskeleton-Assisted Gait

Science.gov (United States)

Torricelli, Diego; Cortés, Camilo; Lete, Nerea; Bertelsen, Álvaro; Gonzalez-Vargas, Jose E.; del-Ama, Antonio J.; Dimbwadyo, Iris; Moreno, Juan C.; Florez, Julian; Pons, Jose L.

2018-01-01

The relative motion between human and exoskeleton is a crucial factor that has remarkable consequences on the efficiency, reliability and safety of human-robot interaction. Unfortunately, its quantitative assessment has been largely overlooked in the literature. Here, we present a methodology that allows predicting the motion of the human joints from the knowledge of the angular motion of the exoskeleton frame. Our method combines a subject-specific skeletal model with a kinematic model of a lower limb exoskeleton (H2, Technaid), imposing specific kinematic constraints between them. To calibrate the model and validate its ability to predict the relative motion in a subject-specific way, we performed experiments on seven healthy subjects during treadmill walking tasks. We demonstrate a prediction accuracy lower than 3.5° globally, and around 1.5° at the hip level, which represent an improvement up to 66% compared to the traditional approach assuming no relative motion between the user and the exoskeleton. PMID:29755336

A Subject-Specific Kinematic Model to Predict Human Motion in Exoskeleton-Assisted Gait.

Science.gov (United States)

Torricelli, Diego; Cortés, Camilo; Lete, Nerea; Bertelsen, Álvaro; Gonzalez-Vargas, Jose E; Del-Ama, Antonio J; Dimbwadyo, Iris; Moreno, Juan C; Florez, Julian; Pons, Jose L

2018-01-01

The relative motion between human and exoskeleton is a crucial factor that has remarkable consequences on the efficiency, reliability and safety of human-robot interaction. Unfortunately, its quantitative assessment has been largely overlooked in the literature. Here, we present a methodology that allows predicting the motion of the human joints from the knowledge of the angular motion of the exoskeleton frame. Our method combines a subject-specific skeletal model with a kinematic model of a lower limb exoskeleton (H2, Technaid), imposing specific kinematic constraints between them. To calibrate the model and validate its ability to predict the relative motion in a subject-specific way, we performed experiments on seven healthy subjects during treadmill walking tasks. We demonstrate a prediction accuracy lower than 3.5° globally, and around 1.5° at the hip level, which represent an improvement up to 66% compared to the traditional approach assuming no relative motion between the user and the exoskeleton.

Human subject research: reporting ethics approval and informed consent in 3 chiropractic journals.

Science.gov (United States)

Lawrence, Dana J

2011-11-01

To date, there have been no reports of ethics board approval or informed consent within the chiropractic literature or within chiropractic research. The purpose of this study was to assess the reporting of ethics approval and informed consent in articles published during the 2008 volume year of 3 chiropractic research journals included in PubMed. A quantitative assessment of the articles published in each journal for the 2008 volume year was performed. Information collected included if the article involved human subject research, if it reported ethics board approval, and if informed consent was given to subjects. Data were collected as descriptive statistics (frequency counts and percentages). In aggregate, 50 articles of a total of 143 published involved human subject research (35%). 44 reported ethics board approval (88%), and 28 reported that informed consent had been obtained (56%). Forty-five percent of articles published in the Journal of Manipulative and Physiological Therapeutics involved human subject research (39/87), of which 95% reported ethics board approval (37/39) and 64% reported informed consent (25/39); 12.5% of articles from the Journal of the Canadian Chiropractic Association involved human subject research (5/40), of which 80% reported ethics board approval (4/5) and 40% reported informed consent (2/5); and 37.5% of articles published in Chiropractic and Osteopathy involved human subject research (6/16), of which 50% reported ethics board approval (3/6) and 17% reported informed consent (1/6). Overall, most articles reported ethics approval, and more than half reported consent. This was harmonious with research on this topic from other disciplines. This situation indicates a need for continued quality improvement and for better instruction and dissemination of information on these issues to researchers, to manuscript reviewers, to journal editors, and to the readers. Copyright © 2011 National University of Health Sciences. Published by Mosby

Determination of Cl, K, and Na in the blood serum of healthy elderly in the city of Sao Paulo, SP; Determinacao de Cl, K e Na em soro sanguineo de idosos saudaveis da cidade de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Araujo, Nathalia Souza de; Saiki, Mitiko, E-mail: natsouzaraujo@yahoo.com.b, E-mail: mitiko@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2009-07-01

This work determined the blood serum concentration of Cl, K, and Na from a healthy elderly population of the city of Sao Paulo, Sao Paulo, Brazil viewing the comparison with reference values used in clinical laboratories. For collecting these samples the present work were approved by the Ethic Committee of the FMUSP and IPEN-CNEN/SP. The quality of the analytical results were evaluated by the analysis of the reference material certification NIST 1577b Bovine Liver. The results presented good accuracy and precision due to the fact that they presented relative errors less than 5.2 % and standard deviation less than 8.6 %. The average concentrations (mmol L{sup -1}) of Cl in the analysed serum were 99.1; the K were 3.9 and the Na were 136.9. The obtained data allows the to conclude that the mostly of the elderly presented Cl, K and Na concentrations in the range of reference values used in the clinical laboratories

Energy balance of Sao Paulo state, Brazil 2008. Calendar year 2007; Balanco energetico do Estado de Sao Paulo 2008. Ano base 2007

Energy Technology Data Exchange (ETDEWEB)

NONE

2008-07-01

This document presents the consolidated annual energy balances and also tables and graphics which detailed the evolution and the present status of offer and demand of each energy resources used by Sao Paulo, Brazil, economy and regionalized and environmental information. It covers the period of 1994 to 2007 and includes energy fluxes of the energy primary and secondary resources, from the production to the final consumption of the main sectors of the state economy.

Astronomical observations with the optical multichannel analyser of the Sao Paulo University

Energy Technology Data Exchange (ETDEWEB)

Codina-Landaberry, S J; de Freitas Pacheco, J A [Universidade Mackenzie, Sao Paulo (Brazil). Centro de Radio-Astronomia e Astrofisica

1979-03-01

The first astronomical observations made with the optical multichannel analyser (OMA) of the Sao Paulo University is reported. A detailed description of the instrumentation is given as well as the results derived from the observation of some emission nebulae.

Improved performance of the Sao Paulo Pelletron

International Nuclear Information System (INIS)

Sala, O.; Stier, M.; Acquadro, J.C.

1981-01-01

The Sao Paulo Pelletron was the first Pelletron constructed by the NEC and also the first to become operational at the end of 1971. Although the Herb Pelletron design was demonstrated from the beginning to be very good (later this was proven by the successful operation of several larger Pelletrons) our machine did suffer from defects in engineering which limited its performance and its application as a reliable tool for research in nuclear physics. This paper describes some of the improvements which we have introduced to increase the reliability of our Pelletron as a research tool in the University. (orig.)

Astronomical observations with the optical multichannel analyser of the Sao Paulo University

International Nuclear Information System (INIS)

Codina-Landaberry, S.J.; Freitas Pacheco, J.A. de

1979-01-01

The first astronomical observations made with the optical multichannel analyser (OMA) of the Sao Paulo University is reported. A detailed description of the instrumentation is given as well as the results derived from the observation of some emission nebulae [pt

Airport Choice in Sao Paulo Metropolitan Area: An Application of the Conditional Logit Model

Science.gov (United States)

Moreno, Marcelo Baena; Muller, Carlos

2003-01-01

Using the conditional LOGIT model, this paper addresses the airport choice in the Sao Paulo Metropolitan Area. In this region, Guarulhos International Airport (GRU) and Congonhas Airport (CGH) compete for passengers flying to several domestic destinations. The airport choice is believed to be a result of the tradeoff passengers perform considering airport access characteristics, airline level of service characteristics and passenger experience with the analyzed airports. It was found that access time to the airports better explain the airport choice than access distance, whereas direct flight frequencies gives better explanation to the airport choice than the indirect (connections and stops) and total (direct plus indirect) flight frequencies. Out of 15 tested variables, passenger experience with the analyzed airports was the variable that best explained the airport choice in the region. Model specifications considering 1, 2 or 3 variables were tested. The model specification most adjusted to the observed data considered access time, direct flight frequencies in the travel period (morning or afternoon peak) and passenger experience with the analyzed airports. The influence of these variables was therefore analyzed across market segments according to departure airport and flight duration criteria. The choice of GRU (located neighboring Sao Paulo city) is not well explained by the rationality of access time economy and the increase of the supply of direct flight frequencies, while the choice of CGH (located inside Sao Paulo city) is. Access time was found to be more important to passengers flying shorter distances while direct flight frequencies in the travel period were more significant to those flying longer distances. Keywords: Airport choice, Multiple airport region, Conditional LOGIT model, Access time, Flight frequencies, Passenger experience with the analyzed airports, Transportation planning

Wind power system for Sao Gabriel, Irece region, Bahia-Brazil; Sistema eolico de Sao Gabriel, regiao de Irece-Bahia

Energy Technology Data Exchange (ETDEWEB)

Bruni, Carlos D' Alexandria [Centro Federal de Educacao Tecnologica da Bahia (CEFET-BA), Salvador, BA (Brazil)], e-mail: carlosbruni@cefetba.br; Camelier, Luiz Alberto A. [Companhia de Engenharia Rural da Bahia, Salvador, BA (Brazil)], e-mail: lcamelier@ig.com.br

2004-07-01

An electric power plant supplied by a wind-generator is the solution for supply drink water on a small community on Sao Gabriel, Irece - Bahia -Brazil. On behalf of the feasibility a wind power system is described in detail concerning it's technical specifications, it's operation, constraints and it's energy demand. Furthermore wind power system supply is described in detail. Simulations is shows how the system is designed to guarantee a reliability in pumping of drinking water powered by wind power system and it's expansion in the future. (author)

Energy Balance of the Sao Paulo State -1998 Base year 1997

International Nuclear Information System (INIS)

1998-01-01

This energy balance of the Sao Paulo State presents the following main topics that can be outstanding: panorama of the energy matrix; supply and demand of energy by source 1983-1997; energy consumption by sector 1983/1997; economic aspects; resources and reserves energy; and balance of the transformation centers 1983/1997

The booster for the pelletron of Sao Paulo

International Nuclear Information System (INIS)

Acquadro, J.C.; Added, N.; Ferraretto, M.D.; Oliveira, O.; Ordonez, J.; Pessoa, E.; Sala, O.; Szanto de Toledo, A.

1992-01-01

This paper describes the necessary modifications in the present acceleration system for the coupling of a superconducting linac to the tandem of Sao Paulo. Final laboratory projectile energies of 15 MV/A to elements from C to Fe should be achieved after installing the two first cryostats (phase I). The superconducting linac will consist of split-ring niobium resonant cavities (F o = 97 MHz and beta = 0.0060, 0.105) that are being built in the Argonne National Laboratory. (Author) 4 refs., 3 figs

The Mesoproterozoic volcano-sedimentary Serra do Itaberaba Group of the Central Ribeira Belt, Sao Paulo State, Brazil: implications for the age of the overlying Sao Roque Group

International Nuclear Information System (INIS)

Juliani, Caetano; Hackspacher, Peter; Fetter, Allen Hutchenson; Dantas, Elton Luiz

2000-01-01

One of the fundamental problems to understanding the evolution of volcano-sedimentary sequences in southeastern Brazil is constraining their depositional ages. Brasiliano tectonic and metamorphic either obscured or destroyed primary features, such as unconformities, as well as other geologic relationships. This problem is exemplified by the Serra do Itaberaba and Sao Roque groups, where the lack of data about the timing of their deposition has prevented resolution of proposed one-and two-stage geotectonic/depositional models. Recent U-Pb zircon data obtained from metavolcanic rocks in the Sao Roque Group indicate that it was deposited between 628 and 607 Ma. New U-Pb zircon data of 1395± 10 Ma for a metandesite in the basal Morro da Pedra Preta Formation (Serra do Itaberaba Group) indicate the maximum age for the beginning of the deposition of the pelites overlying MORB-like basalt. A metarhyolite of the upper unit, the Nhangucu Formation, contains two zircon populations. One yielded an age of 619 ±3 Ma, which defines the crystallization age of the rock, and the other an age of 1449 ±3 Ma, interpreted as inherited xenocrystal grains from older units of the Serra do Itaberaba Group. The younger metarhyolite was affected only by the S 2 foliation, generated during the Brasiliano orogenesis, whereas the Middle Proterozoic metavolcano-sedimentary sequence records additional metamorphic and deformational events, confirming the presence of two different geotectonic cycles. (author)

Annual report 2006 - CPFL Energy - Light and Power Company from Sao Paulo, SP

International Nuclear Information System (INIS)

2006-01-01

This document reports the activities during 2006 of the Sao Paulo Light and Power (CPFL) as follows: society evolution, corporative and ethic management; economic and financial performance; operational performance, sustainability management and corporative responsibility

Apoptosis may determine the release of skeletal alkaline phosphatase activity from human osteoblast-line cells.

Science.gov (United States)

Farley, J R; Stilt-Coffing, B

2001-01-01

Although quantitative measurement of skeletal alkaline phosphatase (sALP) activity in serum can provide an index of the rate of bone formation, the metabolic process that determines the release of sALP - from the surface of osteoblasts, into circulation-is unknown. The current studies were intended to examine the hypothesis that the release of sALP from human osteoblasts is a consequence of apoptotic cell death. We measured the release of sALP activity from human osteosarcoma (SaOS-2) cells and normal human bone cells, under basal conditions and in response to agents that increased apoptosis (TNF-a, okadiac acid) and agents that inhibit apoptosis (IGF-I, calpain, and caspase inhibitors). Apoptosis was determined by the presence of nucleosomes (histone-associated DNA) in the cytoplasm of the cells by using a commercial kit. The results of these studies showed that TNF-a and okadiac acid caused dose- and time-dependent increases in apoptosis in the SaOS-2 cells (r = 0.78 for doses of TNF-a and r = 0.93 for doses of okadiac acid, P sALP activity (e.g., r = 0.89 for TNF-a and r = 0.75 for okadiac acid, P sALP activity (P sALP activity (P sALP release. The associations between apoptosis and sALP release were not unique to osteosarcoma (i.e., SaOS-2) cells, but also seen with osteoblast-line cells derived from normal human bone. Together, these data demonstrate that the release of sALP activity from human osteoblast-line cells in vitro is associated with, and may be a consequence of, apoptotic cell death. These findings are consistent with the general hypothesis that the appearance of sALP activity in serum may reflect the turnover of osteoblast-line cells.

A new energy control system for the Sao Paulo 8UD pelletron

International Nuclear Information System (INIS)

Acquadro, J.C.; Schnitter, U.; Teles, A.P.; Pereira, D.; Sala, O.; Freitas, P.A.B.

1986-01-01

The conventional control slits of the analyzing magnet have been substituted by a new energy control system using a thin carbon foil, for the 8UD Pelletron of the Universidade de Sao Paulo. This report describes the preliminary tests and results. (orig.)

Subject Retrieval from Full-Text Databases in the Humanities

Science.gov (United States)

East, John W.

2007-01-01

This paper examines the problems involved in subject retrieval from full-text databases of secondary materials in the humanities. Ten such databases were studied and their search functionality evaluated, focusing on factors such as Boolean operators, document surrogates, limiting by subject area, proximity operators, phrase searching, wildcards,…

Utilization of bromeliad Tillandsia Usneoides L. in biomonitoring of air pollution in the metropolitan region of Sao Paulo - SP, Brazil; Utilizacao da bromelia Tillandsia Usneoides L. no biomonitoramento da poluicao atmosferica na Regiao metropolitana de Sao Paulo - SP, Brasil

Energy Technology Data Exchange (ETDEWEB)

Albuquerque, Caroline R.; Figueiredo, Ana M.G.; Silva, Barbara C. da; Ticianelli, Regina B., E-mail: calbuuquerque@gmail.com, E-mail: anamaria@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Figueira, Rubens C.L., E-mail: aportellar@yahoo.com.br [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Instituto Oceanografico; Nievola, Catarina C.; Alves, Edenise S.; Domingos, Marisa, E-mail: ccnievola@uol.com.br, E-mail: ealves@ibot.sp.gov.br, E-mail: mmingos@superig.com.br [Instituto de Botanica (IBt-SMA/SP), Sao Paulo, SP (Brazil); Ribeiro, Andreza P., E-mail: andrezp@uninove.br [Universidade Nove de Julho (UNINOVE), Sao Paulo, SP (Brazil)

2013-07-01

In this study, it was determined the metals Cd, Cu, Fe, Mo, Ni, Pb and Sb in plant Tillandsia Usneoides L., an epiphyte species popularly known as old beard and able to absorb water and nutrients directly from air, aiming to estimate the contribution of human activities in atmospheric metal pollution in the metropolitan region of Sao Paulo. The samples were collected at five different points, located near the South West and stretches of highway Mario Covas (SP-21). The Neutron Activation Analysis (NAA) and Optical Emission Spectrometry with Inductively Coupled Plasma (ICP-OES) were the analytical techniques used in the quantification of metals of interest.

Quantifying impacts on air quality of vehicular emissions in Sao Paulo and Rio de Janeiro

Science.gov (United States)

Artaxo, Paulo; Ferreira de Brito, Joel; Godoy, José Marcus; Luiza Godoy, Maria; Junior, Djacinto

2016-04-01

Vehicular emissions in megacities such as Sao Paulo and Rio de Janeiro are increasingly becoming a global issue. The São Paulo Metropolitan Area (SPMA), located in Southeast of Brazil, is a megacity with a population of 18 million people, with 7 million cars and large-scale industrial emissions. Rio de Janeiro is also a large city with different meteorology than São Paulo. All cars in Brazil runs gasohol, with 23% ethanol in gasoline, and for the last 10 years, flex cars that can run on gasohol, ethanol or any mixture dominate the market. Overall ethanol accounts for about 30-40% of fuel burned in both cities. To improve the understanding of vehicular emission impacts on aerosol composition and life cycle in these two large megacities a source apportionment study, combining online and offline measurements, was performed. Aerosols were collected for one year to capture seasonal variability at 4 sites in each city, with inorganic and organic aerosol component being sampled. Organic and elemental carbon were measured using a Sunset Laboratory Dual Optics (transmission and reflectance) Carbon Analyzer and about 22 trace elements has been measured using polarized X-Ray Fluorescence (XRF). Aerosol mass and black carbon were also measured, as well as trace gases to help in aerosol source apportionment. In Sao Paulo, the average PM2.5 mass concentration obtained varied from 9.6 to 12.2 μg m-3 for the several sites, and similar concentrations were measured in Rio de Janeiro. At all sites, organic matter (OM) has dominated fine mode aerosol concentration with 42 to 60% of the aerosol mass. EC accounted for 21 to 31% of fine mode aerosol mass concentration. Sulfate accounted for 21 to 26% of PM2.5 for the sites. Aerosol source apportionment was done with receptor analysis and integration with online data such as PTR-MS, Aethalometers, Nephelometers and ACSM helped to apportion vehicular emissions. For the 8 sites operated in Sao Paulo and Rio de Janeiro, vehicular

Stimulation by parathyroid hormone of sup 45 Ca sup 2+ uptake in osteoblast-like cells: Possible involvement of alkaline phosphatase

Energy Technology Data Exchange (ETDEWEB)

Fukayama, S.; Tashjian, A.H. Jr. (Harvard School of Public Health, Boston, MA (USA))

1990-04-01

We have investigated the actions of human PTH (hPTH-(1-34)) on the association of 45Ca2+ with two human (SaOS-2 and MG-63) and two rat (ROS 17/2.8 and UMR-106) osteoblast-like cell types. In SaOS-2 cells, hPTH-(1-34) binds to specific membrane receptors to activate adenylate cyclase. Treatment of SaOS-2 cells with hPTH-(1-34) resulted in an increase in 45Ca2+ uptake, in a dose-dependent fashion, up to 2- to 4-fold above control values. The increase was first evident at 10 min and persisted for at least 30 min. Treatment with nimodipine, a calcium channel antagonist, was without effect on the stimulatory action of PTH. A similar enhancement of cell-associated 45Ca2+ was observed when the cells were incubated with vasoactive intestinal peptide, which acts via different receptors to activate adenylate cyclase in SaOS-2 cells. Treatment with (Bu)2cAMP also induced an increase in cell-associated 45Ca2+. Pretreatment of SaOS-2 cells with hPTH-(1-34) for 4 h, which induced homologous desensitization to a second challenge with the same peptide for stimulation of cAMP production, did not attenuate the further enhancement of cell-associated 45Ca2+ by a second treatment with hPTH-(1-34). We then examined a possible relationship between alkaline phosphatase (ALPase) and 45Ca2+ uptake. SaOS-2 cells contained high levels of alkaline phosphatase activity and continuously released the enzyme into the medium. Release was enhanced by treatment with hPTH-(1-34) for 10 min. Incubation of cells with levamisole (an inhibitor of the liver/bone/kidney type of ALPase) resulted in a rapid decrease in basal and PTH-stimulated 45Ca2+ uptake, while treatment with L-Phe-Gly-Gly was without effect. Treatment of the cells with ALPase (bovine kidney) enhanced 45Ca2+ uptake. In MG-63 cells, a stimulatory effect of hPTH-(1-34) on cell-associated 45Ca2+ was also observed; however, hPTH-(1-34) did not stimulate cAMP production in MG-63 cells.

Environmental quality of agricultural soils within the Jaguari River Basin - Sao Paulo

International Nuclear Information System (INIS)

Ruby, Elaine Cristina

2009-01-01

Environmental impacts have occurred in various forms and intensities on soil, water and air media. Consequently, several countries have used legal criteria for soil protection, either by means of generic guiding values or through case-by-case risk assessment. The Sao Paulo Environmental Agency (CETESB) pioneered the publication of guiding values for soils and groundwater in 2001. The aim of this study was to evaluate the environmental quality of agricultural soils in comparison to pristine soils (control areas) within the Jaguari river basin, Sao Paulo. The evaluation was carried out through multielement determination by Neutron Activation Analysis Instrumental (INAA) technique. The analyses were also complemented by Optical Emission Spectrometry Coupled Plasma (ICP OES), Atomic Absorption Spectrometry and Graphite Furnace (GFAAS) techniques. The results obtained in the analyzed soil samples were compared to the guiding values established by the Sao Paulo State environmental legislation and revealed that there were no median concentrations above the prevention values. The median concentrations for the elements Sb, As, Cd, Pb, Co, Cu, Cr, Ni, V and Zn were below the reference values, except for Pb. Taking into account the 34 elements determined, there were statistically significant differences (p <0.05) between agricultural and pristine soils only for the elements Ba, As, U and V. Among these elements, Ba presented the highest concentrations in pristine soils. It was concluded, that the environmental quality of agricultural soils within the Jaguari river basin - SP was slightly changed for the given parameters. The results also pointed out for the utilization of U and As as indicators of potential contamination in soils. (author)

Mustard Gas Surrogate, 2-Chloroethyl Ethylsulfide (2-CEES), Induces Centrosome Amplification and Aneuploidy in Human and Mouse Cells

Science.gov (United States)

2014-03-01

increase in aneuploidy in treated  cells .      Methods and Materials    Cell   Culture     Saos2 (human  osteosarcoma ) and NIH3T3 (murine embryonic...fibroblasts)  cells  were obtained  from ATCC (HTB‐85 and CRL‐1658, respectively) and  cultured  in complete media:  Dulbecco’s  Modified Eagle Medium (DMEM...subconfluent  cultures .  After the 5 day incubation,  cells  were treated     with 0.5 μg/ml colcemid (Gibco) for 4 hours.   Cell  media was harvested and retained

Unified costs for the rural electrification in the state of Sao Paulo, Brazil; Custos unificados para a eletrificacao rural em Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Ribeiro, Fernando Selles; Kurahassi, Luiz Fernando; Pazzini, Luiz Henrique Alves; Galvao, Luiz Claudio Ribeiro; Pelegrini, Marcelo Aparecido [Sao Paulo Univ., SP (Brazil). Dept. de Engenharia de Energia e Automacao Eletricas. Grupo de Energia]. E-mail: kurahass@pea.usp.br

2000-07-01

The Banco Nacional de Desenvolvimento Economico e Social - BNDES, a Brazilian bank for the economic and social development - worried about the high connections costs practiced by the energy utilities, made some demands to the Sao Paulo State Government, Brazil to become the agent backer of the rural electrification 'Luz da Terra' program. Two of them was the elaboration and adoption of an unified technical norm privileging the adoption of simplified systems of electric energy distribution and an only system of costs establishment compatible with the goals of low medium connection costs for the state. A model of costs establishment was elaborated through the medium prices of market materials and labor activities whose values were more significant in the final composition of the projects. The model was accepted by the utilities participants of the program as a pattern to establish a reference cost for each project to be executed. The advantage of an unified system is that it allows to each project of grid extension to have its costs of materials and labor activities estimated in the same base, independent of the company involved. In spite of not having been adopted by all the utilities ones, the adoption of an unified system and the establishment of reference costs was essential for the control of rural distribution grids prices in the Sao Paulo State. (author)

História clínica e exame físico em SAOS: clinical history and physical examination Obstructive sleep apnea syndrome

Directory of Open Access Journals (Sweden)

Gleison Marinho Guimarães

2010-06-01

Full Text Available Embora SAOS seja uma patologia comum, é frequentemente subdiagnosticada. Seus sinais e sintomas são, na sua maioria, subjetivos e, portanto, deve haver suspeição diagnóstica quando existir roncos, sonolência diurna, cansaço, desânimo e alteração de humor. Escalas e tabelas com boa sensibilidade, que incluem os sintomas clínicos mais relevantes e dados do exame físico, podem indicar o diagnóstico de SAOS. A confirmação diagnóstica é realizada através de polissonografia, considerada o método padrão ouro.Although obstructive sleep apnea syndrome is a common disease, it often goes undiagnosed. The signs and symptoms of the syndrome are mostly subjective. Therefore, snoring, daytime sleepiness, fatigue, dejection and mood changes should raise the suspicion of obstructive sleep apnea syndrome. Scales and tables that have good sensitivity and include the most relevant clinical symptoms and physical examination results can suggest a diagnosis of obstructive sleep apnea syndrome. The diagnosis is confirmed by polysomnography, which is considered the gold standard method.

Report on {open_quotes}inspection of human subject research in intelligence and intelligence-related projects{close_quotes}

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-01-16

Executive Order 12333, {open_quotes}United States Intelligence Activities,{close_quotes} (1) designates the Department`s intelligence element as a member of the Intelligence Community, and (2) states that no agency within the Intelligence community shall sponsor, contract for or conduct research on human subjects except in accordance with guidelines issued by the Department of Health and Human Services. The Federal policy for the Protection of Human Subjects, which was based on Department of Health and Human Services regulations, was promulgated in Title 10 Code of Federal Regulations Part 745 by the Department of Energy. The purpose of this inspection was to review the internal control procedures used by the Office of Nonproliferation and National Security to manage selected intelligence and intelligence-related projects that involve human subject research.

Assessment of emerging biomarkers of liver injury in human subjects.

Science.gov (United States)

Schomaker, Shelli; Warner, Roscoe; Bock, Jeff; Johnson, Kent; Potter, David; Van Winkle, Joyce; Aubrecht, Jiri

2013-04-01

Hepatotoxicity remains a major challenge in drug development. Although alanine aminotransferase (ALT) remains the gold standard biomarker of liver injury, alternative biomarker strategies to better predict the potential for severe drug-induced liver injury (DILI) are essential. In this study, we evaluated the utility of glutamate dehydrogenase (GLDH), purine nucleoside phosphorylase (PNP), malate dehydrogenase (MDH), and paraxonase 1 (PON1) as indicators of liver injury in cohorts of human subjects, including healthy subjects across age and gender, subjects with a variety of liver impairments, and several cases of acetaminophen poisoning. In the healthy subjects, levels of GLDH and MDH were not affected by age or gender. Reference ranges for GLDH and MDH in healthy subjects were 1-10 and 79-176U/L, respectively. In contrast, the levels of PON1 and PNP were not consistent across cohorts of healthy subjects. Furthermore, GLDH and MDH had a strong correlation with elevated ALT levels and possessed a high predictive power for liver injury, as determined by ROC analysis. In contrast, PON1 and PNP did not detect liver injury in our study. Finally, evaluation of patients with acetaminophen-induced liver injury provided evidence that both GLDH and MDH might have utility as biomarkers of DILI in humans. This study is the first to evaluate GLDH, MDH, PON1, and PNP in a large number of human subjects and, and it provides an impetus for prospective clinical studies to fully evaluate the diagnostic value of GLDH and MDH for detection of liver injury.

A study on elemental composition in epiphytic lichen samples used as bioindicator of air pollution in Sao Paulo city

International Nuclear Information System (INIS)

Montezani, Edmila

2010-01-01

Studies on air pollution have intensified in recent years, due to the diversity of emissions and the effect caused to the health of populations. Consequently, several techniques have been investigated for air pollution evaluation and among them one that has gained considerable attention is that of biomonitoring. In this study chemical elemental levels in the atmosphere of Sao Paulo city were evaluated, by means of passive biomonitoring, using epiphytic Canoparmelia texana species, in order to compare between the results obtained in samples from different sites of Sao Paulo city and in a reference site of Ubatuba city, SP. Neutron activation analysis (NAA) procedure applied in the analyses consisted of irradiating aliquots of samples along with synthetic standards of elements in the nuclear reactor IEA-R1 for 16 hours under a thermal neutron flux of about 5.0 x 10 12 n cm -2 s -1 , followed by gamma ray spectrometry for the determination of As, Br, Ca, Co, Cr, Cs, Fe, K, La, Rb, Sc, Se and Zn. Results obtained in the analyses of lichens samples in replicates presented good reproducibility indicating homogeneity of the prepared samples. The precision and accuracy of the results were evaluated by the analyses of certified reference materials IAEA-336 Lichen and INCT-TL-1 Tea Leaves. Results obtained in the reference materials presented, in general, good precision, with relative standard deviations between 0.4 and 14.8% and good accuracy with relative errors between 0.2 and 8.7%. In Sao Paulo city, the lichens were collected in the following sites: Parque Dom Pedro II, Congonhas, Cidade Universitaria, Lapa, Mooca, Morumbi, Nossa Senhora do O, Parque Ibirapuera, Pinheiros, Santana, Santo Amaro and Taboao da Serra. Element concentrations found in lichens indicated a great variability depending on the sites where the samples were collected. The results obtained in the lichens submitted to the cluster analysis indicated three groups of sampling sites according to the

A study on elemental composition in epiphytic lichen samples used as bioindicator of air pollution in Sao Paulo city; Estudo sobre a composicao elementar nas amostras de liquen epifitico utilizado como bioindicador da poluicao aerea na cidade de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Montezani, Edmila

2010-07-01

Studies on air pollution have intensified in recent years, due to the diversity of emissions and the effect caused to the health of populations. Consequently, several techniques have been investigated for air pollution evaluation and among them one that has gained considerable attention is that of biomonitoring. In this study chemical elemental levels in the atmosphere of Sao Paulo city were evaluated, by means of passive biomonitoring, using epiphytic Canoparmelia texana species, in order to compare between the results obtained in samples from different sites of Sao Paulo city and in a reference site of Ubatuba city, SP. Neutron activation analysis (NAA) procedure applied in the analyses consisted of irradiating aliquots of samples along with synthetic standards of elements in the nuclear reactor IEA-R1 for 16 hours under a thermal neutron flux of about 5.0 x 10{sup 12} n cm{sup -2} s{sup -1}, followed by gamma ray spectrometry for the determination of As, Br, Ca, Co, Cr, Cs, Fe, K, La, Rb, Sc, Se and Zn. Results obtained in the analyses of lichens samples in replicates presented good reproducibility indicating homogeneity of the prepared samples. The precision and accuracy of the results were evaluated by the analyses of certified reference materials IAEA-336 Lichen and INCT-TL-1 Tea Leaves. Results obtained in the reference materials presented, in general, good precision, with relative standard deviations between 0.4 and 14.8% and good accuracy with relative errors between 0.2 and 8.7%. In Sao Paulo city, the lichens were collected in the following sites: Parque Dom Pedro II, Congonhas, Cidade Universitaria, Lapa, Mooca, Morumbi, Nossa Senhora do O, Parque Ibirapuera, Pinheiros, Santana, Santo Amaro and Taboao da Serra. Element concentrations found in lichens indicated a great variability depending on the sites where the samples were collected. The results obtained in the lichens submitted to the cluster analysis indicated three groups of sampling sites

Quality standards proposal for the pipeline gas distribution service in the state of Sao Paulo - Brazil; Proposta de padroes de qualidade para o servico de distribuicao de gas canalizado no Estado de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Galvao, Clovis Badaro; Assad, Luiz Sergio [Secretaria de Estado de Energia, Sao Paulo, SP (Brazil); Bajay, Sergio Valdir [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Engenharia Mecanica

1998-12-31

The Energy Supply Public Utilities Commission of the State of Sao Paulo - CSPE created in April 1998 to regulate the public services of electricity and gas distribution through networks in the State. Within its legal attributions, the future staff of CSPE, still in the Sao Paulo Secretary of State of Energy, put forward standards to regulate the quality of service in the distribution of electricity and pipeline gas in the State. This paper summarises the current, still preliminary, version of these gas standards, that take into account the current practice of COMGAS, international, well proven, standards as well as COMGAS capacity to achieve quality of service gains favoring the consumers. (author) 8 refs., 3 tabs.

Engaging Institutional Review Boards in Developing a Brief, Community-Responsive Human Subjects Training for Community Partners.

Science.gov (United States)

Calzo, Jerel P; Bogart, Laura M; Francis, Evelyn; Kornetsky, Susan Z; Winkler, Sabune J; Kaberry, Julie

2016-01-01

Engaging community partners as co-investigators in community-based participatory research (CBPR) requires certification in the rules, ethics, and principles governing research. Despite developments in making human research protection trainings more convenient and standardized (eg, self-paced Internet modules), time constraints and the structure of the content (which may favor academic audiences) may hinder the training of community partners. This paper is motivated by a case example in which academic and community partners, and stakeholders of a community-based organization actively engaged the leadership of a pediatric hospital-based institutional review board (IRB) in implementing a brief, community-responsive human subjects training session. A 2-hour, discussion-based human subjects training was developed via collaborations between the IRB and the community and academic partners. Interviews with trainees and facilitators after the training were used to evaluate its acceptability and possible future applications. Local IRBs have the potential to assist community partners in building sufficient knowledge of human subjects research protections to engage in specific projects, thereby expediting the progress of vital research to address community needs. We propose the need for developing truncated human subjects education materials to train and certify community partners, and creating formally organized entities within academic and medical institutions that specialize in community-based research to guide the development and implementation of alternative human subjects training certification opportunities for community partners.

Research on DNA methylation of human osteosarcoma cell MGMT and its relationship with cell resistance to alkylating agents.

Science.gov (United States)

Guo, Jun; Cui, Qiu; Jiang, WeiHao; Liu, Cheng; Li, DingFeng; Zeng, Yanjun

2013-08-01

The objective of this study was to explore the O(6)-methylguanine-DNA methyltransferase (MGMT) gene methylation status and its protein expression, as well as the effects of demethylating agent 5-Aza-2'-deoxycytidine (5-Aza-CdR) on MGMT gene expression and its resistance to alkylating agents, and to elucidate MGMT expression mechanism and significance in osteosarcoma. The human osteosarcoma cell lines Saos-2 and MG-63 were collected and treated with 5-Aza-CdR for 6 days. The cells not treated with 5-Aza-CdR were set as a negative control. The genomic DNA was extracted from the Saos-2 and MG-63 cells using methylation-specific PCR to detect the promoter CpG island methylation status of the MGMT gene. Cell sensitivity to alkylating agents before and after drug administration was detected by the MTT method. The variation in MGMT gene mRNA and protein was detected by reverse transcription PCR (RT-PCR) and Western blotting. The MGMT promoter gene of normal Saos-2 cells was methylated, with reduced MGMT mRNA and protein expression; the MGMT mRNA and protein expression of Saos-2 cells treated with 5-Aza-CdR was obviously enhanced, and its sensitivity to alkylating agents was reversed. Meanwhile, with promoter CpG island unmethylation of the MGMT gene, MGMT protein was expressed in the normal MG-63 cells and the MG-63 cells treated with 5-Aza-CdR, and both showed resistance to alkylating agents. The methylation status of the MGMT gene promoter in human osteosarcoma cells reflected the cells' ability to induce MGMT protein expression and can be used as a molecular marker to project the sensitivity of cancer tissues to alkylating agent drugs.

Photodegradation of carotenoids in human subjects

International Nuclear Information System (INIS)

Roe, D.A.

1987-01-01

Photodegradation of vitamins in vitro is responsible for large losses of these nutrients in foods, beverages, and semisynthetic liquid formula diets. In vivo photodegradation of vitamins has been reported for riboflavin in jaundiced infants exposed to blue light and for folate in patients with chronic psoriasis given photochemotherapy. Two recent studies of normal subjects have also shown that photodegradation of carotenoids in plasma occurs with cumulative exposure of the skin to an artificial light source having maximal spectral emission in the UVA range. Females showed a larger effect of the UV light on their plasma carotenoid levels than males. These observations have identified a need for further investigation of the role of sunlight exposure as a determinant of plasma carotenoid levels and vitamin A status in human subjects

34 CFR 97.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Science.gov (United States)

2010-07-01

... Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.118 Applications and proposals lacking definite plans..., or contracts are submitted to departments or agencies with the knowledge that subjects may be...

Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects.

Science.gov (United States)

Robertson, Chelsea L; Ishibashi, Kenji; Mandelkern, Mark A; Brown, Amira K; Ghahremani, Dara G; Sabb, Fred; Bilder, Robert; Cannon, Tyrone; Borg, Jacqueline; London, Edythe D

2015-04-15

Motor response inhibition is mediated by neural circuits involving dopaminergic transmission; however, the relative contributions of dopaminergic signaling via D1- and D2-type receptors are unclear. Although evidence supports dissociable contributions of D1- and D2-type receptors to response inhibition in rats and associations of D2-type receptors to response inhibition in humans, the relationship between D1-type receptors and response inhibition has not been evaluated in humans. Here, we tested whether individual differences in striatal D1- and D2-type receptors are related to response inhibition in human subjects, possibly in opposing ways. Thirty-one volunteers participated. Response inhibition was indexed by stop-signal reaction time on the stop-signal task and commission errors on the continuous performance task, and tested for association with striatal D1- and D2-type receptor availability [binding potential referred to nondisplaceable uptake (BPND)], measured using positron emission tomography with [(11)C]NNC-112 and [(18)F]fallypride, respectively. Stop-signal reaction time was negatively correlated with D1- and D2-type BPND in whole striatum, with significant relationships involving the dorsal striatum, but not the ventral striatum, and no significant correlations involving the continuous performance task. The results indicate that dopamine D1- and D2-type receptors are associated with response inhibition, and identify the dorsal striatum as an important locus of dopaminergic control in stopping. Moreover, the similar contribution of both receptor subtypes suggests the importance of a relative balance between phasic and tonic dopaminergic activity subserved by D1- and D2-type receptors, respectively, in support of response inhibition. The results also suggest that the stop-signal task and the continuous performance task use different neurochemical mechanisms subserving motor response inhibition. Copyright © 2015 the authors 0270-6474/15/355990-08$15.00/0.

Variability of HIV-1 genomes among children and adolescents from Sao Paulo, Brazil.

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Sabri Saeed Sanabani

Full Text Available BACKGROUND: Genetic variability is a major feature of the human immunodeficiency virus type 1 (HIV-1 and considered the key factor to frustrating efforts to halt the virus epidemic. In this study, we aimed to investigate the genetic variability of HIV-1 strains among children and adolescents born from 1992 to 2009 in the state of Sao Paulo, Brazil. METHODOLOGY: Plasma and peripheral blood mononuclear cells (PBMC were collected from 51 HIV-1-positive children and adolescents on ART followed between September 1992 and July 2009. After extraction, the genetic materials were used in a polymerase chain reaction (PCR to amplify the viral near full length genomes (NFLGs from 5 overlapped fragments. NFLGs and partial amplicons were directly sequenced and data were phylogenetically inferred. RESULTS: Of the 51 samples studied, the NFLGs and partial fragments of HIV-1 from 42 PBMCs and 25 plasma were successfully subtyped. Results based on proviral DNA revealed that 22 (52.4% patients were infected with subtype B, 16 (38.1% were infected with BF1 mosaic variants and 4 (9.5% were infected with sub-subtype F1. All the BF1 recombinants were unique and distinct from any previously identified unique or circulating recombinant forms in South America. Evidence of dual infections was detected in 3 patients coinfected with the same or distinct HIV-1 subtypes. Ten of the 31 (32.2% and 12 of the 21 (57.1% subjects with recovered proviral and plasma, respectively, protease sequences were infected with major mutants resistant to protease inhibitors. The V3 sequences of 14 patients with available sequences from PBMC/or plasma were predicted to be R5-tropic virus except for two patients who harbored an X4 strain. CONCLUSIONS: The high proportion of HIV-1 BF1 recombinant, coinfection rate and vertical transmission in Brazil merits urgent attention and effective measures to reduce the transmission of HIV among spouses and sex partners.

Monitoring of global alpha and beta radioactive level in the public water supply of Sao Paulo State, Brazil

International Nuclear Information System (INIS)

Peres, Ana Claudia

2002-01-01

The present work was based in the regulation number 1469 of Brazilian Health Ministry, of 2000, 29 th of December, that establishes the proceedings and responsibilities relatives to control and vigilance of water quality to human consumption and your gauge of potability. In the context the results of the analysis of the gross alpha and gross beta concentrations are presented. They were determined in 143 samples of drinking water supplies of Sao Paulo State in the year of 2001. The gross alpha presented concentrations ranging from <0,001 a 0,182 Bq/L, while the gross beta presented concentrations ranging from <0,001 a 0,872 Bq/L. (author)

Validating in vivo Raman spectroscopy of bone in human subjects

Science.gov (United States)

Esmonde-White, Francis W. L.; Morris, Michael D.

2013-03-01

Raman spectroscopy can non-destructively measure properties of bone related to mineral density, mineral composition, and collagen composition. Bone properties can be measured through the skin in animal and human subjects, but correlations between the transcutaneous and exposed bone measurements have only been reported for human cadavers. In this study, we examine human subjects to collect measurements transcutaneously, on surgically exposed bone, and on recovered bone fragments. This data will be used to demonstrate in vivo feasibility and to compare transcutaneous and exposed Raman spectroscopy of bone. A commercially available Raman spectrograph and optical probe operating at 785 nm excitation are used for the in vivo measurements. Requirements for applying Raman spectroscopy during a surgery are also discussed.

Household dust metal levels in The Sao Paulo metropolitan area

International Nuclear Information System (INIS)

Scapin, Valdirene O.; Scapin, Marcos A.; Sato, Ivone M.

2007-01-01

A study about household dust is being conducted to determine the level of metal contamination in the Sao Paulo Metropolitan Area (SPMA). The SPMA, with 18 million inhabitants, is one of the largest urban areas of the world, with serious environmental problems, due to the great amount of industries, heavy traffic and the disordered growth of population. The pollutants originate from a multiplicity of indoor and outdoor sources. Indoor sources are originated from residual (hair, skin scales), pets, human activities, construction materials, and furnishings as well as biological material (pollen, insect parts).and outdoor pollution, usually from the urban traffic. The pollutant mixture involved in numerous physical and chemical processes and changes its characteristics with time. Its composition and concentration depend on the strengths of indoor sources, the concentration of pollutants outside and the properties of ventilation and air-conditioning systems. It is well recognized that many metals have chronic effects on humans, in particular toddlers, who are at an higher risk compared to adults because they engage in greater hand to-mouth activity and their neurological systems are still developing. The household dust samples were collected from different localities, using vacuum cleaner, and sieved up to particle size -1 ; Mn, 119-369 μg g -1 ; Fe, 372-1464 μg g -1 ; Ni, 33-85 μg g -1 ; Cu, 42-303 μg g -1 ; Zn, 156-1369 μg g -1 and Pb, 26-160 μg g -1 . (author)

The irradiation of human volunteer subjects in research

International Nuclear Information System (INIS)

Rosen, R.

1980-01-01

In medical research radiation is sometimes used to obtain data from healthy individuals. These subjects gain no specific benefit from the research. To safeguard their welfare, constraints are imposed on the dose to be received, on the selection of volunteer subjects, on ensuring their understanding of the procedures and risks, and on obtaining their free consent to participate. The research proposals are assessed by peer review prior to being approved by the host institution. The first example presented describes the use of diagnostic radiography to obtain in vivo data on the femur bone. Conservative dosimetry indicates an expected dose-equivalent per film of 0.5 mSv in bone and 0.18 mSv in bone marrow and gonad tissue. The critical organ total dose-equivalent is estimated to be 7% of the dose-equivalent limit for a volunteer. The second example involves the internal administration of radioactive tracers. Dosimetric calculations indicate an expected whole-body dose-equivalent of 0.5 mSv in the case of C-14 and 0.37 mSv in the case of H-3, these values bejng 10% and 7% of the relevant dose-equivalent limit. Both proposals were given conditional approval. In the generalized research use of volunteer human subjects the rights of the subject, the investigator and the institution need to be protected. At the University of New South Wales procedures have been introduced to govern all experjmental procedures involving human subjects. Some interesting problems which have arisen are discussed. (author)

Different Expression and Localization of Phosphoinositide Specific Phospholipases C in Human Osteoblasts, Osteosarcoma Cell Lines, Ewing Sarcoma and Synovial Sarcoma

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V.Vasco

2017-06-01

Full Text Available Background: Bone hardness and strength depends on mineralization, which involves a complex process in which calcium phosphate, produced by bone-forming cells, was shed around the fibrous matrix. This process is strictly regulated, and a number of signal transduction systems were interested in calcium metabolism, such as the phosphoinositide (PI pathway and related phospholipase C (PLC enzymes. Objectives: Our aim was to search for common patterns of expression in osteoblasts, as well as in ES and SS. Methods: We analysed the PLC enzymes in human osteoblasts and osteosarcoma cell lines MG-63 and SaOS-2. We compared the obtained results to the expression of PLCs in samples of patients affected with Ewing sarcoma (ES and synovial sarcoma (SS. Results: In osteoblasts, MG-63 cells and SaOS-2 significant differences were identified in the expression of PLC δ4 and PLC η subfamily isoforms. Differences were also identified regarding the expression of PLCs in ES and SS. Most ES and SS did not express PLCB1, which was expressed in most osteoblasts, MG-63 and SaOS-2 cells. Conversely, PLCB2, unexpressed in the cell lines, was expressed in some ES and SS. However, PLCH1 was expressed in SaOS-2 and inconstantly expressed in osteoblasts, while it was expressed in ES and unexpressed in SS. The most relevant difference observed in ES compared to SS regarded PLC ε and PLC η isoforms. Conclusion: MG-63 and SaOS-2 osteosarcoma cell lines might represent an inappropriate experimental model for studies about the analysis of signal transduction in osteoblasts

[Yellow fever: reemerging in the state of Sao Paulo, Brazil, 2009].

Science.gov (United States)

Mascheretti, Melissa; Tengan, Ciléa H; Sato, Helena Keiko; Suzuki, Akemi; de Souza, Renato Pereira; Maeda, Marina; Brasil, Roosecelis; Pereira, Mariza; Tubaki, Rosa Maria; Wanderley, Dalva M V; Fortaleza, Carlos Magno Castelo Branco; Ribeiro, Ana Freitas

2013-10-01

To describe the investigation of a sylvatic yellow fever outbreak in the state of Sao Paulo and the main control measures undertaken. This is a descriptive study of a sylvatic yellow fever outbreak in the Southwestern region of the state from February to April 2009. Suspected and confirmed cases in humans and in non-human primates were evaluated. Entomological investigation in sylvatic environment involved capture at ground level and in the tree canopy to identify species and detect natural infections. Control measures were performed in urban areas to control Aedes aegypti . Vaccination was directed at residents living in areas with confirmed viral circulation and also at nearby cities according to national recommendation. Twenty-eight human cases were confirmed (39.3% case fatality rate) in rural areas of Sarutaiá, Piraju, Tejupá, Avaré and Buri. The deaths of 56 non-human primates were also reported, 91.4% were Allouatta sp. Epizootics was confirmed in two non-human primates in the cities of Itapetininga and Buri. A total of 1,782 mosquitoes were collected, including Haemagogus leucocelaenus , Hg. janthinomys/capricornii , and Sabethes chloropterus, Sa. purpureus and Sa. undosus . Yellow fever virus was isolated from a group of Hg. Leucocelaenus from Buri. Vaccination was carried out in 49 cities, with a total of 1,018,705 doses. Nine serious post-vaccination adverse events were reported. The cases occurred between February and April 2009 in areas with no recorded yellow fever virus circulation in over 60 years. The outbreak region occurred outside the original recommended vaccination area with a high percentage of susceptible population. The fast adoption of control measures interrupted the human transmission within a month and the confirmation of viral circulation in humans, monkeys and mosquitoes. The results allowed the identification of new areas of viral circulation but further studies are required to clarify the dynamics of the spread of this disease.

The geotectonic evolution of southern part of Sao Francisco Craton, based in geochronologic interpretation

International Nuclear Information System (INIS)

Teixeira, W.

1985-01-01

Interpretation of available radiometric data from poly metamorphic terranes of southern part of the Sao Francisco Craton demonstrates the importance of geochronology as a tool in the study of ancient crustal evolution. In addition, radiometric study of basic intrusive magmatism helps define the most important epochs of crustal rifting during the Proterozoic. The definition of the southern border of the cratonic area based on distinctive age patterns of the geochronological provinces is also discussed. Finally, the geochronologic evolution of the Bambui platform cover is presented. Approximately 250 radiometric age determinations (Rb-Sr, K-Ar and Pb-Pb methods) were interpreted principally through the use of iso chronic diagrams. The geologic history tectonomagnetic events identified in this study is compared to the crustal evolution of similar segments of the Sao Francisco Craton and elsewhere. (author)

Visceral leishmaniasis in the state of Sao Paulo, Brazil: spatial and space-time analysis.

Science.gov (United States)

Cardim, Marisa Furtado Mozini; Guirado, Marluci Monteiro; Dibo, Margareth Regina; Chiaravalloti, Francisco

2016-08-11

To perform both space and space-time evaluations of visceral leishmaniasis in humans in the state of Sao Paulo, Brazil. The population considered in the study comprised autochthonous cases of visceral leishmaniasis and deaths resulting from it in Sao Paulo, between 1999 and 2013. The analysis considered the western region of the state as its studied area. Thematic maps were created to show visceral leishmaniasis dissemination in humans in the municipality. Spatial analysis tools Kernel and Kernel ratio were used to respectively obtain the distribution of cases and deaths and the distribution of incidence and mortality. Scan statistics were used in order to identify spatial and space-time clusters of cases and deaths. The visceral leishmaniasis cases in humans, during the studied period, were observed to occur in the western portion of Sao Paulo, and their territorial extension mainly followed the eastbound course of the Marechal Rondon highway. The incidences were characterized as two sequences of concentric ellipses of decreasing intensities. The first and more intense one was found to have its epicenter in the municipality of Castilho (where the Marechal Rondon highway crosses the border of the state of Mato Grosso do Sul) and the second one in Bauru. Mortality was found to have a similar behavior to incidence. The spatial and space-time clusters of cases were observed to coincide with the two areas of highest incidence. Both the space-time clusters identified, even without coinciding in time, were started three years after the human cases were detected and had the same duration, that is, six years. The expansion of visceral leishmaniasis in Sao Paulo has been taking place in an eastbound direction, focusing on the role of highways, especially Marechal Rondon, in this process. The space-time analysis detected the disease occurred in cycles, in different spaces and time periods. These meetings, if considered, may contribute to the adoption of actions that aim to

Gamma dosimetry of the uranium deposit in Sao Jose de Espinharas, Paraiba, Brazil

International Nuclear Information System (INIS)

Silva, Alberto Antonio da; Santos Junior, Jose Araujo dos; Cunha, Andre Felippe Vieira da; Amaral, Romilton dos Santos; Oliveira, Iane Andrade de; Bezerra, Jairo Dias; Silva, Flavio Ferreira da

2013-01-01

Radioecology studies contribute to the monitoring of both anthropic and natural radionuclides, as well as their correlation with the ecosystem and the population. Terrestrial sources, which mainly include the primary radionuclides of the 238 U, 232 Th, and 40 K series, contribute to a higher effective dose received by humanity, with 84% from terrestrial radionuclides and another 16% derived from cosmogenic nuclides. Areas with high levels of natural radiation, above the acceptable limits, are of great relevance for the development of dosimetry studies, whose core aims include the preservation of the environment and the control of the population's exposure to radiation. The town of Sao Jose de Espinharas, Paraiba, Brazil, has a uranium oxide mine with an average grade of 1,200 mg/kg. In the present study, non-destructive, in situ assays were performed along the entire radiometrically anomalous area. The results obtained in terms of effective doses varied from 3.79 to 93.80 mSv.y -1 , with an average of 19.47 mSv.y -1 thus leading to the conclusion that all of the monitored points presented environmental doses of above the reference value of 2.4 mSv.y -1 , suggesting that both qualitative and quantitative analyses concerning the environmental matrixes in question need to be performed. (author)

The tectonic evolution of Southern part of the Sao Francisco Craton

International Nuclear Information System (INIS)

Teixeira, W.

1986-01-01

The potentiality of geochronology when it is applied to the geologic context of craton basement of archean areas is shown. Samples from southern part of the Sao Francisco Craton, in Brazil, were collected for petrographic analysis and geochronological data interpretation. The set of radiometric determinations was obtained by K-Ar, Rb-Sr, Pb-Pb and U-Pb methods. (M.C.K.) [pt

Physicochemical characterization of ceramics from Sao Paulo II archaeological site; Caracterizacao fisico-quimica da ceramica do sitio arqueologico Sao Paulo II

Energy Technology Data Exchange (ETDEWEB)

Ribeiro, Rogerio Baria

2013-08-01

Archaeometry is a consolidated field with a wide application of nuclear analytical techniques for the characterization, protection, and restoration of archaeological pieces. This project aimed at studying the elementary chemical composition of 70 ceramic fragments samples from Sao Paulo II archaeological site, located along the Solimoes River channel, next to Coari city, in Brazilian Amazon. The characterization of samples was performed by neutron activation analysis (NAA). By the determination of 24 elements in the ceramic fragments ( Ce, Co, Cr, Cs, Eu, Fe, Hf, K, La, Lu, Na, Nd, Sb, Sm. Rb, Se, Ta, Tb, Th, U, Yb and Zn), it was possible to define groups of samples regarding the similarity/dissimilarity in elementary chemical composition. For such a task, the multivariate statistical methods employed were cluster analysis (C A), principal component analysis (PCA) and discriminant analysis (DA). Afterwards, seven ceramic fragments were selected based on the groups previously established, for the characterization of the site temporal horizon. Those ceramic fragments were analyzed by thermoluminescence (TL) and EPR for dating purposes. The firing temperatures were determined by electron paramagnetic resonance (EPR) technique, in order to infer about some aspects of the ceramic manufacture employed by the ancient peoples that lived in Sao Paulo 11. By the results obtained in this study, it was possible to identify the quantity of clay sources employed by the ceramists and the age of the ceramic pieces. Therefore, the results of this research may contribute to the study on the occupation dynamics in the pre-colonial Brazilian Amazon. (author)

Effects of vinasse accumulation ponds and decantation reservoirs of water used for washing cane sugar in water resources in Dobrada municipality, Sao Paulo State, Brazil; Efeitos da estocagem de vinhaca e das aguas de lavagem da cana-de-acucar na qualidade dos recursos hidricos da regiao de Dobrada, Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Sabadia, Jose Antonio Beltrao; Reboucas, Aldo da Cunha [Sao Paulo Univ., SP (Brazil). Inst. de Geociencias

1996-12-31

This work shows the results of a monitoring carried out in an area of about 21 km{sup 2}, Dobrada Municipality, central west region of the state of Sao Paulo (Brazil), where the impacts in ground water and surface water were evaluated by the infiltration and percolation of vinasse and water used for washing cane sugar, through accumulation ponds and decantation reservoirs, respectively, in areas of Bauru Aquifer (Cretaceous). The Bauru Aquifer, free and porous, occurs in a extended area of 104.000 km{sup 2} in Sao Paulo State, as a major exploitable aquifer (more than 15.000 wells), used for domestic and industrial water supplies. For the groundwater, the following measures were found in analyses exceeding drinking water standards (WHO; CONAMA/Brazil and Sao Paulo State): manganese (0,03 to 3,5 mg/l), iron (0.45 to 34 mg/l), aluminum (1 to 52 mg/l) and phosphate (0,03 to 0.38 mg/l). For superficial water, the following measures exceeded drinking water standards: total iron (3 mg/l) and phosphate (0,035 mg/l). The main purpose of this research is to improve the field methodology to characterize the impacts of vinasse and washing water of cane sugar infiltration/percolation., detaching the relationship between ground and surface water, with the major aim to supply the legislation to protect drinking water resources. (author) 11 refs.

A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2

International Nuclear Information System (INIS)

Okaichi, Kumio; Wang Lihong; Sasaki, Ji-ichiro; Saya, Hideyuki; Tada, Mitsuhiro; Okumura, Yutaka

1999-01-01

Purpose: The 123A point mutation of p53 showed increased radiosensitivity, whereas other mutations (143A, 175H, and 273H) were not affected. To determine the reason for increased radiosensitivity of the 123A mutation, the response of the transformant of 123A mutation to ionizing radiation (IR) was examined and compared to those of transformants with the wild type p53 or other point mutations (143A, 175H, and 273H). Methods and Materials: Stable transformants with a mutant or wild type p53 made by introducing cDNA into the human osteosarcoma cell line, Saos-2, which lacks an endogenous p53 were used. The transcriptional activity of mutant p53 was examined using a yeast functional assay. The transformants were examined for the accumulation of p53, the induction of p21 Waf1/Cip1/Sdi1 (hereafter referred to as p21), and the other response of p53-responsive genes (MDM2, Bax, and Bcl-2) by Western blotting. Apoptosis was analyzed by detection of DNA fragmentation. Results: The 123A point mutation of p53 was detected as a wild type in the yeast functional assay. The 123A mutant accumulated p53 in response to IR. The 123A mutant did not induce p21, but normally responded to MDM2, Bax, and Bcl-2. The 123A mutant entered apoptosis earlier than the wild type p53 transformant, and induced Fas at earlier in response to IR. Conclusion: The 123A mutant led to apoptosis, but not p21 expression in response to IR. The occurrence of apoptosis, but not induction of p21, corresponded to the radiosensitivity in the transformant. The early occurrence of apoptosis in 123A transformants may depend on the early induction of Fas

Trace elements in human, cattle and swine teeth, measured by external beam PIXE-PIGE setup

International Nuclear Information System (INIS)

Tabacniks, M.H.; Rizzutto, M.A.; Added, N.; Liguori Neto, R.; Acquadro, J.C.; Vilela, M.; Oliveira, T.R.C.F.; Markarian, R.A.; Mori, M.

2001-01-01

The use of animal teeth to replace human teeth in dentistry school classes and to test chemicals and fillings, motivated for a better characterization of the elementary composition of their enamel, since some of the chemical properties, adhesion and chemical compatibility may depend on these parameters. Cattle, swine and human teeth were collected by dentists of the University of Sao Paulo. These teeth came primarily from Sao Paulo region and were analyzed for trace elements at the Open Nuclear Physics Laboratory, using a high energy external proton beam, PIXE-PIGE setup

Geology and geochronology of Cardoso Island, in the southeastern coast of Sao Paulo State; Geologia e geocronologia da Ilha de Cardoso, sudeste do Estado de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Weber, Werner

1998-07-01

This aim of work is the geological and geochronological study of rocks cropping out on Cardoso Island, on the southeastern coast of Sao Paulo States, close to be boundary with Parana State. The Island with an area of about 151 km{sup 2} is a protected area administered by the Forest Institute of Environment Secretariat of the State of Sao Paulo. It is mountanious, with a peak at 814 m, and is covered by dense Mata Atlantica vegetation. The terrains which compose the island are mainly an igneous complex with light grey leucocratic, inequigranular, medium - to coarse-grained syenites. The predominant Tres Irmaos Syenite (STI), composed of pyroxene, hornblende, and perthitic to mesoperthitic microcline, has a magmatic flow structures, and is cut by the Cambriu alkali-feldspar Granites (GC), which is pinkish grey, leucocratic and medium-grained. Geochemical analysis of STI and GC demonstrate their meta luminous alkaline nature and late-orogenic to an orogenic character. The geochronological results suggest that the bodies were formed between 620 and 570 My according to the U-Pb method in zircons, with cooling between 597 and 531 My (K-Ar in amphiboles). Whole rock Sm-Nd analysis yield T{sub DM} ages in the Meso and Paleoproterozoic (1.200 - 2.200 My). belt of low grade meta sedimentary rocks occurs in the northern part of the island. Quartz schist, quartz-mica schist and mica-quartz schist, often containing andaluzite and cordierite, predominate. The geochemical and geochronological data suggest that the sources of the metasediments were andesites of continental arc whose protolities separated from the mantle during the Paleoproterozoic, between 1.800 and 2.200 My. These metasediments probably continue on the continent in the Taquari region and extend southwards in narrow strips between the granitoids of the Paranagua Domain. Although quaternary deposits are expressive, they were not studied in details since they were not the objectives of this study. (author)

Guidelines for the development and environmental protection of the outcrop area in the Guarani aquifer system in Sao Paulo State, Brazil; Diretrizes para o desenvolvimento e protecao ambiental da area de afloramento do Sistema Aquifero Guarani no estado de Sao Paulo, Brasil

Energy Technology Data Exchange (ETDEWEB)

Alburquerque Filho, J. L.; Carvalho, A. M. de; Ikematsu, P.; Costa Barbosa, M.; Iritani, M.; Nogueira Pressinoti, M. M.; Rocha, G.; Pereira Militao da Silva, M.; Theodorovicz, A.

2012-11-01

The Guarani aquifer system (GAS) is an important public water source. The unconfined areas are those where the aquifer is more vulnerable to contamination, justifying the creation of a Protection and Recovery Source Area (Area de Protecao e Recuperacao de Manancial - APRM), as established in Act 9.866/97 of Sao Paulo State. We present here the results of the project Environmental Diagnosis in Support of the Plan for the Development and Environmental Protection Plan of the Outcrop Area of the Guarani Aquifer System in Sao Paulo State (Plano de Desenvolvimento e Protecao Ambiental da Area de Afloramento do Sistema Aquifero Guarani no Estado de Sao Paulo PDPA-SAG) and describe the areas of intervention defined by this law. The characterization of the area studied focuses on the physical and socio-economic aspects of the region, in addition to the pertinent legislation. Partial results indicate that the condition of the aquifer is satisfactory, but territorial discipline continues to be of prime importance. (Author)

FAP Group Supervision: Reporting Educational Experiences at the University of Sao Paulo, Brazil

Science.gov (United States)

Wielenska, Regina Christina; Oshiro, Claudia Kami Bastos

2012-01-01

The present article describes and analyzes educational experiences related to the teaching of FAP for psychology graduate students and psychiatry residents at the University of Sao Paulo. The first experience involved psychology graduate students and includes an example of the shaping process occurring within the supervisor-supervisee…

Statistical annual by energy in the municipalities of Sao Paulo State, Brazil - 2006

International Nuclear Information System (INIS)

2008-01-01

This document has as objective the compilation and dissemination of the consumption data corresponding of the main energetics used in the municipalities of Sao Paulo State, Brazil in the year of 2006. The considered energetics are: electric energy, natural gas, petroleum derivatives; hydrated alcohol and biodiesel

Application of INAA to provenance study of ceramics from Baixo Sao Francisco River, Sergipe, Brazil

International Nuclear Information System (INIS)

Santos, J.O.; Munita, C.S.; Toyota, Rosimeiri G.; Vergne, C.

2007-01-01

The study of the physical and chemical characteristics of crafts, in association with historical and archaeological research, has allowed for the reconstruction of ancient community habits. Archaeological studies include several techniques to reconstruct ancient cultures. Since ceramics represent a sophisticated merging of previously separate domains of human knowledge and experience, these objects are studied by means of archaeometric methods. In recent years an interdisciplinary research program was started between Museu Arqueologico de Xingo (MAX) and Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP) to study the ancient ceramist cultures from Xingo region, located in Sergipe, Brazilian Northeast. Recent studies conducted in the area have showed the existence of an independent ceramist group without relation to the ceramist group well established in the Brazilian Northeast, Tupiguarani and Aratu. Instrumental neutron activation analysis, INAA, is a suitable technique for provenance studies. In this work the chemical composition of 103 samples: 30 clays and 73 ceramics from Barracao archaeological site, from Baixo Sao Francisco, were analyzed. This analysis allowed for the definition of compositional groups of ceramics according to the chemical similarities of ceramic paste, which reveals the raw material composition used in the manufacturing process by prehistoric man. The outliers were identified by means robust Mahalanobis distance. The results were interpreted by means of cluster analysis, principal components analysis and discriminant analysis. The results obtained in this work, in association with archaeological information, allowed for the identification of the ceramic groups in relation to the ceramist occupations of the Xingo area. This work contributes for the reconstruction of the Baixo Sao Francisco region communities and for the reconstitution of the Brazilian Northeast ceramist population. (author)

Angiotensin-converting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Quechua.

Science.gov (United States)

Bigham, Abigail W; Kiyamu, Melisa; León-Velarde, Fabiola; Parra, Esteban J; Rivera-Ch, Maria; Shriver, Mark D; Brutsaert, Tom D

2008-01-01

The I-allele of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been associated with performance benefits at high altitude (HA). In n = 142 young males and females of largely Quechua origins in Peru, we evaluated 3 specific hypotheses with regard to the HA benefits of the I-allele: (1) the I-allele is associated with higher arterial oxygen saturation (Sa(O(2))) at HA, (2) the I-allele effect depends on the acclimatization state of the subjects, and (3) the putative I-allele effect on Sa(O(2)) is mediated by the isocapnic hypoxic ventilatory response (HVR, l/min(1)/% Sa(O(2))(1)). The subject participants comprised two different study groups including BLA subjects (born at low altitude) who were lifelong sea-level residents transiently exposed to hypobaric hypoxia (<24 h) and BHA subjects (born at HA) who were lifelong residents of HA. To control for the possibility of population stratification, Native American ancestry proportion (NAAP) was estimated as a covariate for each individual using a panel of 70 ancestry-informative molecular markers (AIMS). At HA, resting and exercise Sa(O(2)) was strongly associated with the ACE genotype, p = 0.008 with approximately 4% of the total variance in Sa(O(2)) attributed to ACE genotype. Moreover, I/I individuals maintained approximately 2.3 percentage point higher Sa(O(2)) compared to I/D and D/D. This I-allele effect was evident in both BLA and BHA groups, suggesting that acclimatization state has little influence on the phenotypic expression of the ACE gene. Finally, ACE genotype was not associated with the isocapnic HVR, although HVR had a strong independent effect on Sa(O(2)) (p = 0.001). This suggests that the I-allele effect on Sa(O(2)) is not mediated by the peripheral control of breathing, but rather by some other central cardiopulmonary effect of the ACE gene on the renin-angiotensin-aldosterone system (RAAS).

Biomonitoring of the atmospheric pollution using lichens in the metropolitan area of Sao Paulo city, Brazil

International Nuclear Information System (INIS)

Saiki, M.; Fuga, A.; Alves, E.R.; Vasconcellos, M.B.A.; Marcelli, M.P.

2007-01-01

The atmospheric pollution of Sao Paulo city is a serious problem due to the expansion of industrial area, increasing number of vehicles and population density. This work presents results obtained in the analysis of lichens collected in different sites of Sao Paulo city and in non-polluted areas of Atlantic Forest. Concentrations of twenty elements were determined in Canoparmelia texanaspecies and comparisons were made between the results obtained in lichens from different sites. High concentrations of the elements As, Ba, Cd, Co, Cr, Fe, La, Mn, Sb and Zn were found for samples collected in sites located near industries and petrochemical plant. Br and Sb concentrations were also high in lichens from sites affected by vehicular emissions. (author)

Historical analysis of the oil leakage in the Sao Sebastiao channel, state of Sao Paulo, Brazil; Analise historica dos vazamentos de oleo no canal de Sao Sebastiao, SP

Energy Technology Data Exchange (ETDEWEB)

Poffo, Iris Regina F.; Xavier, Jose Carlos de M.; Serpa, Ricardo Rodrigues [CETESB, Sao Paulo, SP (Brazil); Schaeffer-Novelli, Yara [Sao Paulo Univ., SP (Brazil). Inst. de Quimica

2000-07-01

Preventing accidents is better than remedying. In order to establish this concept a study was conducted in order to give information about and to prevent sea oil spill accidents. Its first part addressed the main causes of 220 occurrences in north coast of State of Sao Paulo, Brazil based on both CETESB - Companhia de Tecnologia de Saneamento Ambiental and PETROBRAS - Petroleo Brasileiro S. A. data banks. These causes were classified in source, type and mode of failure. In the second part a methodology was developed in order to classify consequences from these events based on two environmental damage indexes regarding ecological and social-economic aspects. Shipping accidents and pipeline failures were responsible for major damages. The most often events caused by operational and mechanical failures mainly in ships and pier were responsible for medium and low severities. (author)

Interaction of Protein Phosphatase 1δ with Nucleophosmin in Human Osteoblastic Cells

International Nuclear Information System (INIS)

Haneji, Tatsuji; Teramachi, Jumpei; Hirashima, Kanji; Kimura, Koji; Morimoto, Hiroyuki

2012-01-01

Protein phosphorylation and dephosphorylation has been recognized as an essential mechanism in the regulation of cellular metabolism and function in various tissues. Serine and threonine protein phosphatases (PP) are divided into four categories: PP1, PP2A, PP2B, and PP2C. At least four isoforms of PP1 catalytic subunit in rat, PP1α, PP1γ1, PP1γ2, and PP1δ, were isolated. In the present study, we examined the localization and expression of PP1δ in human osteoblastic Saos-2 cells. Anti-PP1δ antibody recognized a protein present in the nucleolar regions in Saos-2 cells. Cellular fractionation revealed that PP1δ is a 37 kDa protein localized in the nucleolus. Nucleophosmin is a nucleolar phosphoprotein and located mainly in the nucleolus. Staining pattern of nucleophosmin in Saos-2 cells was similar to that of PP1δ. PP1δ and nucleophosmin were specifically stained as dots in the nucleus. Dual fluorescence images revealed that PP1δ and nucleophosmin were localized in the same regions in the nucleolus. Similar distribution patterns of PP1δ and nucleophosmin were observed in osteoblastic MG63 cells. The interaction of PP1δ and nucleophosmin was also shown by immunoprecipitation and Western analysis. These results indicated that PP1δ associate with nucleophosmin directly in the nucleolus and suggested that nucleophosmin is one of the candidate substrate for PP1δ

Distortion-Product Otoacoustic Emission Measured Below 300 Hz in Normal-Hearing Human Subjects

DEFF Research Database (Denmark)

Christensen, Anders Tornvig; Ordoñez Pizarro, Rodrigo Eduardo; Hammershøi, Dorte

2017-01-01

, a custom-built low-frequency acoustic probe was put to use in 21 normal-hearing human subjects (of 34 recruited). Distortion-product otoacoustic emission (DPOAE) was measured in the enclosed ear canal volume as the response to two simultaneously presented tones with frequencies f1 and f2. The stimulus...

Radiogeologic reconnaissance in Perus region, Sao Paulo, Brazil

International Nuclear Information System (INIS)

Coelho, P.E.F.P.

1980-01-01

The determination of the means and the identification of the radiometric anomalies, and the classification of this anomalies orgin, and it probable correlation with uraniferous secundary minerals from Perus and Taipas were studied. Petrological, stratigraphic, tectonic and geochronological studies in this region were done. The radiometric anomalies was observed in granitic-pegmatic massifs, later Sao Roque group. The radiocitivity of this area was affected by litology, being the pegmatite more radiogenic than granite. The topography is also a influent factor to detected radioactivity. The cinthylometry was efficient to U an Th anomalies detection. Three kinds of radioctive focus were detected by microautoradiography method [pt

Feasibility study on energy conservation at Sao Paulo state primary schools in the Federative Republic of Brazil

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

A feasibility study has been performed on the energy conservation project aimed at the future CDM in relation with energy consumption in the lighting equipment at the Sao Paulo state primary schools in the Federative Republic of Brazil. Out of about 5,500 primary schools existing in Sao Paulo, 3,414 schools were selected as the objects of the surveys and discussions. The present program intends to introduce energy saving facilities such as high-efficiency fluorescent lamps and controls for illuminating the primary schools to save the energies and reduce emission of the global warming gases. In this economy project, the owners do not need to make initial investments, wherein the required funds are taken care by conservation of electric power during the service contract period. If about 3,000 schools are selected as the object, a fund of about 2.3 billion yen will be required in total. Total energy conservation quantity during 15 years from 2002 to 2016 as achieved by this project will be 532,740 MWh, corresponding to 114,540 tons of crude oil. The effect of reducing the emission of global warming gases will be 110,949 t-CO2 during the same period of time. (NEDO)

Characterization of the brazilian alcohol program in the State of Sao Paulo: production costs to plants and distillery homogeneous groups

International Nuclear Information System (INIS)

Miyake, M.Y.; Chung, S.L.; Telhada, M.A.L.

1987-01-01

The ethanol producing plants in the State of Sao Paulo present variation in scale of production, productivity and cost structure. This paper presents production costs and analyses the competitiveness of neat ethanol with respect to gasoline, for each of the eight homogeneous groups of distilleries in operation in the State of Sao Paulo. The study shows that, at prices of march 1986, there is a variation of operational costs in the range of 1.46 to 1.95 cruzados per liter of hydrous ethanol. The reference price, including operational costs and interest on capital, varies from 2.47 to 3.15 cruzados per liter. These prices do not consider subsidies given by the Government under the Brazilian National Alcohol Program. The price of hydrous ethanol in Barrel Equivalent of Oil goes from 33.3 to 43.1 american dollars, showing that ethanol is not currently competitive with gasoline. (author)

SEISMIC STUDY OF THE AGUA DE PAU GEOTHERMAL PROSPECT, SAO MIGUEL, AZORES.

Science.gov (United States)

Dawson, Phillip B.; Rodrigues da Silva, Antonio; Iyer, H.M.; Evans, John R.

1985-01-01

A 16 station array was operated over the 200 km**2 central portion of Sao Miguel utilizing 8 permanent Instituto Nacional de Meterologia e Geofisica stations and 8 USGS portable stations. Forty four local events with well constrained solutions and 15 regional events were located. In addition, hundreds of unlocatable seismic events were recorded. The most interesting seismic activity occurred in a swarm on September 6 and 7, 1983 when over 200 events were recorded in a 16 hour period. The seismic activity around Agua de Pau was centered on the east and northeast slopes of the volcano. The data suggest a boiling hydrothermal system beneath the Agua de Pau volcano, consistent with a variety of other data.

Comparison of blood serum selenium concentrations from elderly population living in Sao Paulo city and literature data

International Nuclear Information System (INIS)

Saiki, Mitiko; Alves, Edson R.; Vasconcellos, Marina B.A.; Sumita, Nairo M.; Jaluul, Omar; Jacob Filho, Wilson

2005-01-01

Selenium is an essential nutrient of fundamental importance to human biology. This element is a component of the enzyme glutathione peroxidase that avoids the formation of free radicals protecting the organism against the oxidative damage. The Se concentrations in serum vary from one part of the world to another and this fact has been satisfactorily explained as a consequence of different Se intakes of the population. The main objective of this paper was the determination of serum Se concentrations in healthy elderly population included in a program for 'Successful Ageing' of the Hospital das Clinicas, Sao Paulo University Medical School. The blood samples were collected after a 12 h fast from 32 subjects aged 60 to 87 years. The blood was centrifuged after completely clotted and 4.0 mL of serum were freeze.dried for Se determination using neutron activation analysis. The serum samples and Se standard were irradiated for 16 h under a thermal neutron flux of de 5 x 10 12 n cm - '2 s -1 at the IEA-R1 nuclear reactor. Se was determined by measuring the gamma activity of 75 Se using an HGe detector coupled to a gamma ray spectrometer. The mean value of (0.92±0.07) μmol L -1 was obtained for serum Se concentration. This value is within the data used as reference values in clinical laboratories and those published in literature. Results obtained for certified reference materials NIST 1566b Oyster Tissue and NIST 1577b Bovine Liver showed good precision and agreed with the certified values. The relative standard deviation of the results was lower than 4.8 % and relative error lower than 0.97 %. Detection limit value obtained for serum Se determination was 0.003 μmol L-1. (author)

Neoproterozoic alkaline magmatism in Ilha do Cardoso, southeastern coast of Sao Paulo State, Brazil

International Nuclear Information System (INIS)

Weber, Werner; Basei, Miguel A.S.; Siga Junior, Oswaldo; Sato, Kei

2001-01-01

This work focuses on the geology and geochronology of rocks cropping out on Cardoso Island, on the southeastern coast of Sao Paulo State, close to the boundary with Parana State. The island, with an area of about 151 km 2 is a protected area administered by the Forest Institute of the Secretariat for the Environment of the State of Sao Paulo. It is mountainous, with a peak at 814 m, and is covered by dense Atlantic Forest vegetation. The island is made up mainly of an igneous complex with light grey leucocratic, inequigranular, medium to coarse-grained syenites. The Tres Irmaos Syenite (STI), composed of pyroxene, hornblende, and perthitic to mesoperthitic microcline, predominates has magmatic flow structures, and it cut by the pinkish grey, leucocratic medium-grained Cambriu alkali-feldspar granites (GC). Geochemical analysis of STI and GC demonstrate their metaluminous alkaline nature and late orogenic to anorogenic character. The bodies formed between 620 and 570 Ma according to U-Pb dating of zircons and cooled between 597 and 531 Ma (K-Ar in amphiboles). Whole rock Sm-Nd analyses yield Meso- and Paleoproterozoic TDM ages (1,500 - 2,200 Ma). A belt of low-grade metasedimentary rocks occurs in the northern part of the island. Quartz schist, quartz-mica schist and mica-quartz schist, often-containing andalusite and cordierite, predominate. Geochemical and geochronological data suggest that the sources of the metasediments were continental arc andesites of whose protoliths separated from the mantle between 1,800 and 2,200 Ma during the Paleoproterozoic. These metasediments probably continue on the continent in the Taquari region and extend southwards in narrow strips between the granitoids of the Paranagua Domain. (author)

Ethics is for human subjects too: participant perspectives on responsibility in health research.

Science.gov (United States)

Cox, Susan M; McDonald, Michael

2013-12-01

Despite the significant literature as well as energy devoted to ethical review of research involving human subjects, little attention has been given to understanding the experiences of those who volunteer as human subjects. Why and how do they decide to participate in research? Is research participation viewed as a form of social responsibility or as a way of obtaining individual benefits? What if anything do research subjects feel they are owed for participation? And what do they feel that they owe the researcher? Drawing on in-depth individual interviews conducted in 2006 and 2007 with 41 subjects who participated in a variety of types of health research in Canada, this paper focuses on subject perspectives on responsibility in research. Highlighting the range of ways that subjects describe their involvement in research and commitments to being a 'good' subject, we present a typology of narratives that sheds new light on the diverse meanings of research participation. These narratives are not mutually exclusive or prescriptive but are presented as ideal types typifying a set of circumstances and values. As such, they collectively illuminate a range of motivations expressed by human subjects as well as potential sources of vulnerability. The typology adds a new dimension to the literature in this area and has significant implications for researchers seeking more human-subject centred approaches to research recruitment and retention, as well as research ethics boards trying to better anticipate the perspectives of prospective participants. Copyright © 2013 Elsevier Ltd. All rights reserved.

Medical students as human subjects in educational research

Directory of Open Access Journals (Sweden)

Adina L. Kalet

2013-02-01

Full Text Available Introduction: Special concerns often arise when medical students are themselves the subjects of education research. A recently completed large, multi-center randomized controlled trial of computer-assisted learning modules for surgical clerks provided the opportunity to explore the perceived level of risk of studies where medical students serve as human subjects by reporting on: 1 the response of Institutional Review Boards (IRBs at seven institutions to the same study protocol; and 2 the thoughts and feelings of students across study sites about being research subjects. Methods: From July 2009 to August 2010, all third-year medical students at seven collaborating institutions were eligible to participate. Patterns of IRB review of the same protocol were compared. Participation burden was calculated in terms of the time spent interacting with the modules. Focus groups were conducted with medical students at each site. Transcripts were coded by three independent reviewers and analyzed using Atlas.ti. Results: The IRBs at the seven participating institutions granted full (n=1, expedited (n=4, or exempt (n=2 review of the WISE Trial protocol. 995 (73% of those eligible consented to participate, and 207 (20% of these students completed all outcome measures. The average time to complete the computer modules and associated measures was 175 min. Common themes in focus groups with participant students included the desire to contribute to medical education research, the absence of coercion to consent, and the low-risk nature of the research. Discussion: Our findings demonstrate that risk assessment and the extent of review utilized for medical education research vary among IRBs. Despite variability in the perception of risk implied by differing IRB requirements, students themselves felt education research was low risk and did not consider themselves to be vulnerable. The vast majority of eligible medical students were willing to participate as research

Comparison of blood serum selenium concentrations from elderly population living in Sao Paulo city and literature data; Comparacao da concentracao de selenio em soro sanguineo da populacao de idosos da cidade de Sao Paulo com os dados da literatura

Energy Technology Data Exchange (ETDEWEB)

Saiki, Mitiko; Alves, Edson R.; Vasconcellos, Marina B.A. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil). Lab. de Analise por Ativacao Neutronica]. E-mail: mitiko@ipen.br; Sumita, Nairo M.; Jaluul, Omar; Jacob Filho, Wilson [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina

2005-07-01

Selenium is an essential nutrient of fundamental importance to human biology. This element is a component of the enzyme glutathione peroxidase that avoids the formation of free radicals protecting the organism against the oxidative damage. The Se concentrations in serum vary from one part of the world to another and this fact has been satisfactorily explained as a consequence of different Se intakes of the population. The main objective of this paper was the determination of serum Se concentrations in healthy elderly population included in a program for 'Successful Ageing' of the Hospital das Clinicas, Sao Paulo University Medical School. The blood samples were collected after a 12 h fast from 32 subjects aged 60 to 87 years. The blood was centrifuged after completely clotted and 4.0 mL of serum were freeze.dried for Se determination using neutron activation analysis. The serum samples and Se standard were irradiated for 16 h under a thermal neutron flux of de 5 x 10{sup 12} n cm{sup -}'2 s{sup -1} at the IEA-R1 nuclear reactor. Se was determined by measuring the gamma activity of {sup 75}Se using an HGe detector coupled to a gamma ray spectrometer. The mean value of (0.92{+-}0.07) {mu}mol L{sup -1} was obtained for serum Se concentration. This value is within the data used as reference values in clinical laboratories and those published in literature. Results obtained for certified reference materials NIST 1566b Oyster Tissue and NIST 1577b Bovine Liver showed good precision and agreed with the certified values. The relative standard deviation of the results was lower than 4.8 % and relative error lower than 0.97 %. Detection limit value obtained for serum Se determination was 0.003 {mu}mol L-1. (author)

Assessment of Consumer Exposure to Salmonella spp., Campylobacter spp., and Shiga Toxin-Producing Escherichia coli in Meat Products at Retail in the City of Sao Paulo, Brazil.

Science.gov (United States)

Ristori, Christiane Asturiano; Rowlands, Ruth Estela Gravato; Martins, Cecília Geraldes; Barbosa, Maria Luisa; Dos Santos, Luis Fernando; Jakabi, Miyoko; de Melo Franco, Bernadette Dora Gombossy

2017-08-01

Meat products may be vehicles of bacterial pathogens to humans, and Salmonella spp., Campylobacter spp., and Shiga toxin-producing Escherichia coli (STEC) are the most relevant. The aim of this study was to generate data on prevalence of these three pathogens in 552 samples of meat products (hot dogs, pork sausages, raw ground beef, and raw chicken legs) sold at retail in the city of Sao Paulo, Brazil. Salmonella spp. was detected in 5.8% (32/552) of samples, comprising pork sausages 62.5% (20/32) and chicken legs 37.5% (12/32). The counts of Salmonella spp. were low, ranging from Salmonella Typhimurium (28.1%), Salmonella I 4,[5],12:i:- (15.6%), Salmonella Enteritidis (12.5%), Salmonella Derby, and Salmonella Brandenburg (9.4%). Campylobacter spp. was detected in 33 samples (6.0%), comprising chicken legs (82%) and ground beef (18%). All samples were negative for STEC. These results suggest that meat products when subjected to inadequate cooking and/or cross-contamination with other products ready for consumption can lead to occurrence of outbreaks, highlighting the risks associated with them.

Studies of osteoporosis in urban residents of Sao Paulo, Brazil, using isotope related techniques

International Nuclear Information System (INIS)

Borelli, A.

2000-01-01

This project is aimed at defining the peak of bone mass in an urban population chosen randomly on account of the great miscegenation in Sao Paulo. It is quite important to know the peak of bone mass and the factors that would interfere in the amount of bone formed as they are valuable guides for future plans of osteoporosis prevention. In our previous meeting it was decided to increase the number of individuals studied from 210 to 350 and proceed with the evaluation of patient information according with the questionnaire proposed. In this report it is presented the results on bone mineral density of lumbar L1-L4 and neck of femur in the total of 350 patients (175 women and 175 men). The complete data, as well as the information obtained from the questionnaire will be sent in the future reports as programed in the meeting of Sao Paulo

Circulating ApoJ is closely associated with insulin resistance in human subjects.

Science.gov (United States)

Seo, Ji A; Kang, Min-Cheol; Ciaraldi, Theodore P; Kim, Sang Soo; Park, Kyong Soo; Choe, Charles; Hwang, Won Min; Lim, Dong Mee; Farr, Olivia; Mantzoros, Christos; Henry, Robert R; Kim, Young-Bum

2018-01-01

Insulin resistance is a major risk factor for type 2 diabetes. ApolipoproteinJ (ApoJ) has been implicated in altered pathophysiologic states including cardiovascular and Alzheimer's disease. However, the function of ApoJ in regulation of glucose homeostasis remains unclear. This study sought to determine whether serum ApoJ levels are associated with insulin resistance in human subjects and if they change after interventions that improve insulin sensitivity. Serum ApoJ levels and insulin resistance status were assessed in nondiabetic (ND) and type 2 diabetic (T2D) subjects. The impacts of rosiglitazone or metformin therapy on serum ApoJ levels and glucose disposal rate (GDR) during a hyperinsulinemic/euglycemic clamp were evaluated in a separate cohort of T2D subjects. Total ApoJ protein or that associated with the HDL and LDL fractions was measured by immunoblotting or ELISA. Fasting serum ApoJ levels were greatly elevated in T2D subjects (ND vs T2D; 100±8.3 vs. 150.6±8.5AU, Pinsulin, HOMA-IR, and BMI. ApoJ levels were significantly and independently associated with HOMA-IR, even after adjustment for age, sex, and BMI. Rosiglitazone treatment in T2D subjects resulted in a reduction in serum ApoJ levels (before vs. after treatment; 100±13.9 vs. 77±15.2AU, P=0.015), whereas metformin had no effect on ApoJ levels. The change in ApoJ levels during treatment was inversely associated with the change in GDR. Interestingly, ApoJ content in the LDL fraction was inversely associated with HOMA-IR. Serum ApoJ levels are closely correlated with the magnitude of insulin resistance regardless of obesity, and decrease along with improvement of insulin resistance in response only to rosiglitazone in type 2 diabetes. Copyright © 2017 Elsevier Inc. All rights reserved.

Utilization of bromeliad Tillandsia Usneoides L. in biomonitoring of air pollution in the metropolitan region of Sao Paulo - SP, Brazil

International Nuclear Information System (INIS)

Albuquerque, Caroline R.; Figueiredo, Ana M.G.; Silva, Barbara C. da; Ticianelli, Regina B.; Figueira, Rubens C.L.; Ribeiro, Andreza P.

2013-01-01

In this study, it was determined the metals Cd, Cu, Fe, Mo, Ni, Pb and Sb in plant Tillandsia Usneoides L., an epiphyte species popularly known as old beard and able to absorb water and nutrients directly from air, aiming to estimate the contribution of human activities in atmospheric metal pollution in the metropolitan region of Sao Paulo. The samples were collected at five different points, located near the South West and stretches of highway Mario Covas (SP-21). The Neutron Activation Analysis (NAA) and Optical Emission Spectrometry with Inductively Coupled Plasma (ICP-OES) were the analytical techniques used in the quantification of metals of interest

Perspectives for distributed generation of electricity in the States of Sao Paulo, Bahia and Mato Grosso; Perspectivas da geracao distribuida de eletricidade nos estados de Sao Paulo, Bahia e Mato Grosso

Energy Technology Data Exchange (ETDEWEB)

Bajay, Sergio Valdir; Leite, Alvaro Afonso Furtado [Universidade Estadual de Campinas (NIPE/UNICAMP), SP (Brazil). Nucleo Interdisciplinar de Planejamento Energetico], Email: bajay@fem.unicamp.br; Carvalho, Claudio Bezerra de [Universidade do Estado da Bahia (UNEB), Alagoinhas, BA (Brazil); Dorileo, Ivo Leandro [Universidade Federal do Mato Grosso (UFMT), Cuiaba, MT (Brazil). Nucleo Interdisciplinar de Estudos em Planejamento Energetico

2006-07-01

This paper addresses the concept of distributed generation of electricity and the current support policies for such kind of generation in the country. Their diffusion perspectives in the States of Sao Paulo, Bahia and Mato Grosso are discussed. The more promising technologies and new policies for them are pointed out. (author)

Can Human Subject Pool Participation Benefit Sociology Students?

Science.gov (United States)

Chin, Lynn Gencianeo; Gibbs Stayte, Patricia

2015-01-01

Instructors at non-research institutions are less able to expose their students to research firsthand. Utilizing human subject pools (HSPs) in class may be a solution. Given that HSPs tend to be used in introduction to psychology classes at research institutions, we examine a community college HSP to answer three questions: (1) Do community…

Characterization of the PROALCOOL in the State of Sao Paulo:, Brazil establishment of homogeneous groups of plants and distilleries; Caracterizacao do PROALCOOL no Estado de Sao Paulo: formacao de grupos homogeneos de usinas e destilarias

Energy Technology Data Exchange (ETDEWEB)

Shih, L.C.; Hwa, C.M.F.; Andreoni, S.; Myiake, M.Y. [Instituto de Pesquisas Tecnologicas (IPT), Sao Paulo, SP (Brazil)

1987-12-31

A methodology to stratify the ethanol plants operating in the State of Sao Paulo, Brazil, in homogeneous groups is presented. This group was obtained by multivariate stratification techniques considering factors as scale of production, agricultural productivity, industrial efficiency and effective industrial capacity utilization. This methodology differs from those adopted by the Fundacao Getulio Vargas and the Organizacao dos Plantadores de Cana-Orplana who consider only one variable- the scale of production. The advantage of this multivariate stratification is that the result clusters reflect more accurately the differences among the existing distilleries. 4 refs., 2 tabs.

Emerging Futures for Sao Tome & Principe’s International Airport Campus

Science.gov (United States)

2007-12-03

from Illinois State University and a Culinary Arts degree from New England Culinary Institute. He is currently a research assistallt with the Land...Director. We would also like to thank the College of Fine and Applied Arts and the East St. Louis Action Research Project for their financial contributions...airportS. Reliance on tourism carries risks to the citizens of Sao Tome in the form of cheapening customs and traditions and adaptation of local arts

Energy balance of Sao Paulo state, Brazil 2008. Calendar year 2007

International Nuclear Information System (INIS)

2008-01-01

This document presents the consolidated annual energy balances and also tables and graphics which detailed the evolution and the present status of offer and demand of each energy resources used by Sao Paulo, Brazil, economy and regionalized and environmental information. It covers the period of 1994 to 2007 and includes energy fluxes of the energy primary and secondary resources, from the production to the final consumption of the main sectors of the state economy

Energy balance of Sao Paulo state, Brazil 2009. Calendar year 2008

International Nuclear Information System (INIS)

2009-01-01

This document presents the consolidated annual energy balances and also tables and graphics which detailed the evolution and the present status of offer and demand of each energy resources used by Sao Paulo, Brazil, economy and regional and environmental information. It covers the period of 1995 to 2008 and includes energy fluxes of the energy primary and secondary resources, from the production to the final consumption of the main sectors of the state economy

Determination of Cl, K, and Na in the blood serum of healthy elderly in the city of Sao Paulo, SP

International Nuclear Information System (INIS)

Araujo, Nathalia Souza de; Saiki, Mitiko

2009-01-01

This work determined the blood serum concentration of Cl, K, and Na from a healthy elderly population of the city of Sao Paulo, Sao Paulo, Brazil viewing the comparison with reference values used in clinical laboratories. For collecting these samples the present work were approved by the Ethic Committee of the FMUSP and IPEN-CNEN/SP. The quality of the analytical results were evaluated by the analysis of the reference material certification NIST 1577b Bovine Liver. The results presented good accuracy and precision due to the fact that they presented relative errors less than 5.2 % and standard deviation less than 8.6 %. The average concentrations (mmol L -1 ) of Cl in the analysed serum were 99.1; the K were 3.9 and the Na were 136.9. The obtained data allows the to conclude that the mostly of the elderly presented Cl, K and Na concentrations in the range of reference values used in the clinical laboratories

Electron beam application for studies carried out with real domestic sewage from Sao Paulo wastewater treatment plants

International Nuclear Information System (INIS)

Borrely, S.I.; Sampa, M.H.O.; Duarte, C.L.

2001-01-01

The incompatibility between industrial development and clean environment requires intensive search for waste mitigation technology. Since the aquatic resources have been the most impacted from the environments, improvements on wastewater treatment technologies have been considered. The Nuclear Research Institute has dedicated attention to this problem since 1990. According to the Governmental Sewage Company, SABESP, Sao Paulo Metropolitan Region, RMSP, is treating 18 cubic meters of sewage per second at five stations. The throughput of each station is: ETE Barueri - 9.5 m 3 /s; ETE ABC - 3.0 m 3 /s; ETE Sao Miguel - 1.5 m 3 /s; ETE Parque Novo Mundo - 2.5 m 3 /s and ETE Suzano - 1.5 m 3 /s. Real effluents from the municipalities have been submitted to electron beam accelerator for different purposes, and using batch system. The samplings were composite and the wastewater were irradiated at Pyrex vessels, 246 mL per sample. The radiation doses were defined by current variation and the energy was fixed in 1.4MeV. The conveyor velocity was 6,72 m/min. A Dynamitron EBA, 37,5kW was the electron source

Increasing trends of sleep complaints in the city of Sao Paulo, Brazil.

Science.gov (United States)

Santos-Silva, Rogerio; Bittencourt, Lia Rita Azeredo; Pires, Maria Laura Nogueira; de Mello, Marco Tulio; Taddei, Jose Augusto; Benedito-Silva, Ana Amelia; Pompeia, Celine; Tufik, Sergio

2010-06-01

The aim of this study was to compare the prevalence of sleep habits and complaints and to estimate the secular trends through three population-based surveys carried out in 1987, 1995, and 2007 in the general adult population of the city of Sao Paulo, Brazil. Surveys were performed using the same three-stage cluster-sampling technique in three consecutive decades to obtain representative samples of the inhabitants of Sao Paulo with respect to gender, age (20-80 years), and socio-economic status. Sample sizes were 1000 volunteers in 1987 and 1995 surveys and 1101 in a 2007 survey. In each survey, the UNIFESP Sleep Questionnaire was administered face-to-face in each household selected. For 1987, 1995, and 2007, respectively, difficulty initiating sleep (weighted frequency %; 95% CI) [(13.9; 11.9-16.2), (19.15; 16.8-21.6), and (25.0; 22.5-27.8)], difficulty maintaining sleep [(15.8; 13.7-18.2), (27.6; 24.9-30.4), and (36.5; 33.5-39.5)], and early morning awakening [(10.6; 8.8-12.7), (14.2; 12.2-16.5), and (26.7; 24-29.6)] increased in the general population over time, mostly in women. Habitual snoring was the most commonly reported complaint across decades and was more prevalent in men. There was no statistically significant difference in snoring complaints between 1987 (21.5; 19.1-24.2) and 1995 (19.0; 16.7-21.6), but a significant increase was noted in 2007 (41.7; 38.6-44.8). Nightmares, bruxism, leg cramps, and somnambulism complaints were significantly higher in 2007 compared to 1987 and 1995. All were more frequent in women. This is the first study comparing sleep complaints in probabilistic population-based samples from the same metropolitan area, using the same methodology across three consecutive decades. Clear trends of increasing sleep complaints were observed, which increased faster between 1995 and 2007 than from 1987 to 1995. These secular trends should be considered a relevant public health issue and support the need for development of health care and

Human Subjects Protection and Technology in Prevention Science: Selected Opportunities and Challenges

OpenAIRE

Pisani, Anthony R.; Wyman, Peter A.; Mohr, David C.; Perrino, Tatiana; Gallo, Carlos; Villamar, Juan; Kendziora, Kimberly; Howe, George W.; Sloboda, Zili; Brown, C. Hendricks

2016-01-01

Internet-connected devices are changing the way people live, work, and relate to one another. For prevention scientists, technological advances create opportunities to promote the welfare of human subjects and society. The challenge is to obtain the benefits while minimizing risks. In this article, we use the guiding principles for ethical human subjects research and proposed changes to the Common Rule regulations, as a basis for discussing selected opportunities and challenges that new techn...

Interaction of Human Osteoblast-Like Saos-2 and MG-63 Cells with Thermally Oxidized Surfaces of a Titanium-Niobium Alloy

Czech Academy of Sciences Publication Activity Database

Vandrovcová, Marta; Jirka, Ivan; Novotná, Katarína; Lisá, Věra; Frank, Otakar; Kolská, Z.; Starý, V.; Bačáková, Lucie

2014-01-01

Roč. 9, č. 6 (2014), e100475 E-ISSN 1932-6203 R&D Projects: GA ČR(CZ) GAP108/10/1858; GA ČR(CZ) GAP107/12/1025; GA MPO FR-TI3/088 Institutional support: RVO:67985823 ; RVO:61388955 Keywords : thermally oxidized surface * titanium-niobium * TiO2 * osteoblast * macrophage Subject RIV: EI - Biotechnology ; Bionics Impact factor: 3.234, year: 2014

La experiencia del partido dos trabalhadores en la alcadía de Sao Paulo

Directory of Open Access Journals (Sweden)

Lúcio KOWARICK

2009-11-01

Full Text Available RESUMEN: En este artículo, Lucio Kowarick y André Singer analizan la gestión del Partido dos Trabalhadores en la Alcaldía de Sao Paulo encabezada por Luiza Erundina. Con esta evaluación pretenden conocer la acción del PT a través de uno de sus principales elementos de construcción del PT, el gobierno de las ciudades, que complementa a los otros dos, la vinculación con los movimientos sindicales y populares y la acción parlamentaria.ABSTRACT: In this article, Lucio Kowarick and Andre Singer analyses the government of Sao Paulo by Partido dos Trabalhadores, with Luiza Erundina. With this evaluation, they try to know the action of PT through one of the main elements of contruction of PT, the government of cities. The other are links with trade unions and popular movements and parliamentarian action.

Modernization perspectives of the Sao Paulo State sugarcane sector through the clean development mechanism and potential carbon credits generation

Energy Technology Data Exchange (ETDEWEB)

Coelho, Suani Teixeira; Lora, Beatriz Acquaro [Brazilian Reference Center on Biomass (CENBIO/USP), SP (Brazil)], Emails: suani@iee.usp.br, blora@iee.usp.br

2009-07-01

The world-wide necessity of greenhouse gases mitigation and the intergovernmental mobilization to reach the objectives established by the United Nations Framework on Climate Change (UNFCCC) has opened space for the renewable energy increase in the world's energy matrix. In Brazil, the solid sugarcane industry currently develops business in the scope of the clean development mechanism (CDM) under the Kyoto's Protocol, by means of 18 biomass-based projects, with renewable energy generation through bagasse cogeneration at 20 Sao Paulo State's sugarcane production units. The projects activity's consists of increasing the efficiency in the bagasse cogeneration facilities, qualifying the units to sell surplus electricity to the national grid, avoiding the dispatch of the same amount of energy produced by fossil-fuelled thermal plants to that grid. The reduced emissions are measured in carbon equivalent and can be converted into negotiable credits. The objective of this study was to build a 'state of art' scenario, calculating the potential emissions reduction through CDM projects for the sugarcane sector of Sao Paulo State, in which we consider the adherence of all the production units of the State to the CDM projects. The technological parameters used to elaborate the scenario were provided by the Sao Paulo State Government Bioenergy Special Commission and the baseline factor used of 0,268 tCO{sub 2}e/MWh was the adopted by the CDM projects in operation in the State. The sugarcane database for the calculations was the production ranking provided by UNICA for the 2006/2007 season. In the most conservative scenario (40 bar bagasse) 131 units could generate 607 MWm of surplus power avoiding the emission of 1.404.593 tCO{sub 2}e/year. For the 92 bar (bagasse and straw) scenario, the units could generate 3.055 MWm of surplus power avoiding 12.199.443 tCO{sub 2}e/year. (author)

Absorption of orally administered 65Zn by normal human subjects

International Nuclear Information System (INIS)

Aamodt, R.L.; Rumble, W.F.; Johnston, G.S.; Markley, E.J.; Henkin, R.I.

1981-01-01

Despite studies by several investigators of human gastrointestinal 65Zn absorption, implications of these data for evaluation of functional zinc status are unclear because limited numbers of normal subjects have been studied. To evaluated zinc absorption in normal humans, 75 subjects (31 women, 44 men, ages 18 to 84 yr) were given 10 micro Ci carrier-free 65Zn orally after an overnight fast. Absorption calculated from total body retention measured 7, 14, and 21 days after administration of tracer was 65 +/- 11% (mean +/- 1 SD), range from 40 to 86%. Comparison of these results with those for patients with a variety of diseases indicate that patients exhibit a wider range of absorption and, in four of six studies patients exhibit decreased mean zinc absorption. These results of gastrointestinal zinc absorption in a large number of normal humans offer a basis for a clearer comparison with data from patients who exhibit abnormalities of zinc absorption

The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects

Science.gov (United States)

Hruska, M W; Amico, J A; Langaee, T Y; Ferrell, R E; Fitzgerald, S M; Frye, R F

2005-01-01

Aims Rosiglitazone, a thiazolidinedione antidiabetic medication used in the treatment of Type 2 diabetes mellitus, is predominantly metabolized by the cytochrome P450 (CYP) enzyme CYP2C8. The anti-infective drug trimethoprim has been shown in vitro to be a selective inhibitor of CYP2C8. The purpose of this study was to evaluate the effect of trimethoprim on the CYP2C8 mediated metabolism of rosiglitazone in vivo and in vitro. Methods The effect of trimethoprim on the metabolism of rosiglitazone in vitro was assessed in pooled human liver microsomes. The effect in vivo was determined by evaluating rosiglitazone pharmacokinetics in the presence and absence of trimethoprim. Eight healthy subjects (four men and four women) completed a randomized, cross-over study. Subjects received single dose rosiglitazone (8 mg) in the presence and absence of trimethoprim 200 mg given twice daily for 5 days. Results Trimethoprim inhibited rosiglitazone metabolism both in vitro and in vivo. Inhibition of rosiglitazone para-hydroxylation by trimethoprim in vitro was found to be competitive with apparent Ki and IC50 values of 29 µm and 54.5 µm, respectively. In the presence of trimethoprim, rosiglitazone plasma AUC was increased by 31% (P = 0.01) from 2774 ± 645 µg l−1 h to 3643 ± 1051 µg l−1 h (95% confidence interval (Cl) for difference 189, 1549), and half-life was increased by 27% (P = 0.006) from 3.3 ± 0.5 to 4.2 ± 0.8 h (95% Cl for difference 0.36, 1.5). Trimethoprim reduced the para-O-sulphate rosiglitazone/rosiglitazone and the N-desmethylrosiglitazone/rosiglitazone AUC(0–24) ratios by 22% and 38%, respectively. Conclusions These results indicate that trimethoprim is a competitive inhibitor of CYP2C8-mediated rosiglitazone metabolism in vitro and that trimethoprim administration increases plasma rosiglitazone concentrations in healthy subjects. PMID:15606443

Tangible and intangible costs of "protecting human subjects": The impact of the National Research Act of 1974 onuniversity research activities

Directory of Open Access Journals (Sweden)

Frederic Jacobs

2004-11-01

Full Text Available This article (1 examines the overall structure of regulatory research oversight in the United States; (2 details the origins and evolution of federal legislation pertaining to the protection of human subjects in biomedical and behavioral treatment and research; and (3 describes the expansion of oversight regulation from biomedical and behavioral treatment areas to the social sciences. In addition, the paper describes three areas identified by compliance administrators as susceptible to abuse: (1 informed consent, (2 assessment of risks and benefits, and (3 equitable selection of human subjects. There is a discussion of existing tensions in the implementation of oversight policies and procedures. Finally, the paper identifies four issues for future consideration: (1 scope of the mandate regarding protection of human subjects, (2 impact on the nature of research being undertaken, (3 financial burden of compliance and oversight activities, and (4 ethical standards, constraints, and potential.

High-dose interferon-alpha2a exerts potent activity against human immunodeficiency virus type 1 not associated with antitumor activity in subjects with Kaposi's sarcoma

NARCIS (Netherlands)

Frissen, P. H.; de Wolf, F.; Reiss, P.; Bakker, P. J.; Veenhof, C. H.; Danner, S. A.; Goudsmit, J.; Lange, J. M.

1997-01-01

Anti-human immunodeficiency virus type 1 (HIV-1) activity was assessed in HIV-1-infected homosexual and bisexual men receiving 18-36 MIU/day of recombinant interferon (IFN)-alpha2a for Kaposi's sarcoma (KS). The median baseline HIV-1 RNA level was 4.99 log10 copies/mL. Seventeen subjects (68%)

Natural radionuclides in soils from Sao Paulo State cerrado forest

International Nuclear Information System (INIS)

Miranda, Marcia V.F.E.S.; Farias, Emerson E.G. de; Cantinha, Rebeca S.; Franca, Elvis J. de

2015-01-01

Considering the long life history, forests should be preferentially evaluated for the monitoring of radionuclides, mainly artificial radioisotopes. However, little is known about nuclides from Uranium and Thorium series, as well as, K-40, in soils from the Sao Paulo State forests. Soils are the main reservoir of natural radionuclides for vegetation, thereby deserving attention. Taking into account the advantages of High-Resolution Gamma-ray Spectrometry (HRGS), diverse radionuclides can be quantified simultaneously. In this work natural radionuclides in soils from the Estacao Ecologica de Assis were evaluated by HRGS. Samples of 0-10 cm depth were collected under crown projection of most abundant tree species of long-term plots installed within the Estacao Ecologica de Assis, Sao Paulo State, Brazil. After drying and milling until 0.5 mm particle size, test portions of 30 g were transferred to polypropylene vials, sealed with silicone and kept under controlled conditions until 30 days to achieve secular equilibrium. A group of gamma-ray spectrometers was used to analyze about 27 samples by 80,000 seconds. Activity concentrations of Pb-214, Ac-228 and K-40 and their respective expanded analytical uncertainties at the 95% confidence level were calculated by Genie software from Canberra. Abnormal values were not detected for radionuclides in soils samples, however K-40 activity concentrations changed considerably due to the mineral cycling, in which K and, consequently K-40, is mainly stocked in vegetation in spite of soils. (author)

Natural radionuclides in soils from Sao Paulo State cerrado forest

Energy Technology Data Exchange (ETDEWEB)

Miranda, Marcia V.F.E.S.; Farias, Emerson E.G. de; Cantinha, Rebeca S.; Franca, Elvis J. de, E-mail: mvaleria@cnen.gov.br, E-mail: emersonemiliano@yahoo.com.br, E-mail: rebecanuclear@gmail.com, E-mail: ejfranca@cnen.gov.br [Centro Regional de Ciencias Nucleares do Nordeste (CRCN-NE/CNEN-PE), Recife, PE (Brazil)

2015-07-01

Considering the long life history, forests should be preferentially evaluated for the monitoring of radionuclides, mainly artificial radioisotopes. However, little is known about nuclides from Uranium and Thorium series, as well as, K-40, in soils from the Sao Paulo State forests. Soils are the main reservoir of natural radionuclides for vegetation, thereby deserving attention. Taking into account the advantages of High-Resolution Gamma-ray Spectrometry (HRGS), diverse radionuclides can be quantified simultaneously. In this work natural radionuclides in soils from the Estacao Ecologica de Assis were evaluated by HRGS. Samples of 0-10 cm depth were collected under crown projection of most abundant tree species of long-term plots installed within the Estacao Ecologica de Assis, Sao Paulo State, Brazil. After drying and milling until 0.5 mm particle size, test portions of 30 g were transferred to polypropylene vials, sealed with silicone and kept under controlled conditions until 30 days to achieve secular equilibrium. A group of gamma-ray spectrometers was used to analyze about 27 samples by 80,000 seconds. Activity concentrations of Pb-214, Ac-228 and K-40 and their respective expanded analytical uncertainties at the 95% confidence level were calculated by Genie software from Canberra. Abnormal values were not detected for radionuclides in soils samples, however K-40 activity concentrations changed considerably due to the mineral cycling, in which K and, consequently K-40, is mainly stocked in vegetation in spite of soils. (author)

Evaluation on the effectiveness of actions for controlling infestation by rodents in Campo Limpo region, Sao Paulo Municipality, Brazil.

Science.gov (United States)

de Masi, Eduardo; Vilaça, Pedro José; Razzolini, Maria Tereza Pepe

2009-08-01

Rodents are responsible for the transmission of more than 60 diseases both to human beings and to domestic animals. The increase in rodent infestation in a given area brings several health problems to the nearby population. Thus, when infestation increases, it is time to take intervention measures. Although many countries have implemented programs aimed at controlling rodent infestation, literature on studies evaluating the effectiveness of intervention measures in urban areas is scarce. Aimed at contributing to the understanding of rodents' population dynamics in urban areas, the objective of this study was to evaluate the effectiveness of the control methods proposed by "Programa de Vigilancia e Controle de Roedores do Municipio de Sao Paulo" (Program for Rodents Surveillance and Control in Sao Paulo Municipality), conducted on Jardim Comercial District. As a first step, a survey to assess infestation rates was conducted in 1529 dwellings located in the area studied. After that, a chemical control upon rodents was accomplished in every dwelling infested. One week and six months after completion of control measures, a new evaluation on infestation rates was carried out, in order to verify the effectiveness of the procedures taken and to estimate the re-infestation capacity. Initial infestation rate was 40.0%, and the final infestation rate, 14.4%. Therefore, the effectiveness of the control methods utilized was 63.8%. It can thus be concluded that the control methods applied were quite effective.

Chemical characterization of organic particulate matter from on-road traffic in Sao Paulo, Brazil

NARCIS (Netherlands)

Oyama, Beatriz Sayuri; Andrade, Maria de Fatima; Herckes, Pierre; Dusek, Ulrike; Rockmann, Thomas; Holzinger, Rupert

2016-01-01

This study reports emission of organic particulate matter by light-duty vehicles (LDVs) and heavy-duty vehicles (HDVs) in the city of Sao Paulo, Brazil, where vehicles run on three different fuel types: gasoline with 25% ethanol (called gasohol, E25), hydrated ethanol (E100), and diesel (with 5%

Rb-Sr geochronology from Sao Felix to Xingu: preliminary results

International Nuclear Information System (INIS)

Lafon, J.M.; Pereira, E.D.; Silva Barradas, J.A. da

1991-01-01

Rb-Sr systematics have been applied on rocks from the Sao Felix do Xingu region, in the southeastern part of the State of Para. An age of 2716 ± 34 Ma with IR of 0.70292 ± 0.00030 (MSWD = 1.54) and an age of 2677 ± 50 Ma with IR of 0.70161 ± 0.00022 (MSWD = 5.21) had been obtained for a granitic body and a tonalitic body respectively, both of them associated to the green stones belts that occur in this area. Gneisses from the Xingu complex gave an age of 2574 ± 57 Ma with an IR of 0.70416 ± 0.00054 (MSWD = 5.06). An age of 1653 ± 14 Ma with IR of 0.70823 ± 0.02361 (MSWD = 1.71) had been obtained for the Velho Guilherme granite that crosscut the granite-green stones terrains. Such geochronological data show the existence of a magmatic event between 2.72 Ga and 2.68 Ga and permit us to conclude on the archaean age of the green stones terrains. (author)

Investigation of wind characteristics and wind energy assessment in Sao Joao do Cariri (SJC) - Paraiba, Brazil

Energy Technology Data Exchange (ETDEWEB)

Lima, Laerte; Filho, Celso

2010-09-15

In this study wind characterization and wind energy assessment of the Sao Joao do Cariri (SJC) in Paraiba state situated in Brazilian northeast. The average wind speed and temperature for 25 and 50 m were found 4,74m/s, 24,46C and 5,31m/s 24,25C with wind speed predominate direction of SSE (165 degrees). Weibull shape, scale ,Weibull fit wind speed and Power wind density found 2,54, 5,4m/s, 4,76m/s and 103W/m2 for 25m wind height measurements and 2,59, 6,0m/s, 5,36m/s and 145W/m2 for 50m wind height measurements.

Food group contribution of essential elements of the Sao Paulo State market basket

International Nuclear Information System (INIS)

Avegliano, Roseane P.; Maihara, Vera A.; Silva, Fabio F. da

2009-01-01

To establish a Market Basket of Sao Paulo state seventy-one foods, with a mean consumption of more than 2 g day -1 per person, were grouped into 30 food categories. The food groups were: cereals, leguminous, leafy vegetables, fruity vegetables, tuberous vegetables, tropical fruits, other fruits, flours, pastas, breads, biscuits, prime grade beef, standard grade beef, pork meats, other meats, poultry, milk/cream, other dairy products, sugars, sweets, salts, sauces, oils, fats, alcoholic beverages, non-alcoholic beverages, coffee, ready-made dishes, saltwater and freshwater fishes. Information about individual food consumption was obtained from a recent national household food budget survey 'POF 2002-2003' conducted by the Brazilian Institute for Geography and Statistics from July 2002 to June 2003. Sampling and kitchen preparation of foods were carried out in restaurants of the University of Sao Paulo. Each food item was individually prepared table-ready. Foods of the same group were mixed, homogenized, pulverized and analyzed for the determination of Ca, Cr, Fe, K, Na and Zn concentrations by Instrumental Neutron Activation Analysis. Average daily intake of each element was calculated by multiplying the element concentration in the food by the corresponding weight of the ready-to-consume food group. The contribution of each food group to the total daily intake of elements by the ready-to-consume food groups of the Market Basket was evaluated. The food groups representing the highest contributions were salts: 79% Na; breads: 37% Fe and 46% Cr; cereals: 19% Zn and milk/cream: 58% Ca and 24% K. (author)

Triacylglycerol Accumulation is not primarily affected in Myotubes established from Type 2 Diabetic Subjects

DEFF Research Database (Denmark)

Gaster, Michael; Beck-Nielsen, Henning

2006-01-01

In the present study, we investigated triacylglycerol (TAG) accumulation, glucose and fatty acid (FA) uptake, and glycogen synthesis (GS) in human myotubes from healthy, lean, and obese subjects with and without type 2 diabetes (T2D), exposed to increasing palmitate (PA) and oleate (OA...... uptake (P0.05). These results indicate that (1) TAG accumulation is not primarily affected in skeletal muscle tissue of obese and T2D; (2) induced inhibition of oxidative phosphorylation is followed by TAG accumulation...... in skeletal muscle of obese and T2D subjects is adaptive....

ETHICS IN HEALTH CARE: INDUCEMENT AND HUMAN SUBJECTS

Directory of Open Access Journals (Sweden)

MUNIR HOSSAIN TALUKDER

2011-05-01

Full Text Available Currently, most health researchers or donor organizations considerinducement as a vital part in promoting research. They propose benefits, such as post research free medical treatment, food, insurance facilities, or even cash, in order to meet sufficient number of subjects. So, inducement may influence one to participate in a research. Is it ethical to offer inducement to human subjects? What are the risks in such practice? What will happen if the donor agencies use subjects by hiding possible risks from them? When an inducement can satisfy ethical criteria? The CIOMS, FDA, and other ethical guidelines hold that inducement is unethical because it involves enough risk for voluntary informed consent. Supporting this position, a group of ethicists has argued that inducement undermines voluntariness especially when subjects are poor and vulnerable, and thus, unethical. In contrast to them, others argue that inducement contributes to discover new knowledge which can improve miserable condition of the poor. In their view, an inducement maintains all ethical criteria including subject’s autonomy, and therefore, morally permissible. The paper focuses this debate and analyzes both types ofargument. It examines whether inducement invalidate informed consent.Even if inducement may not violate the basic components of informedconsent, the paper concludes, subjects may claim a prima facie right to enjoy research outcomes.

Computer science security research and human subjects: emerging considerations for research ethics boards.

Science.gov (United States)

Buchanan, Elizabeth; Aycock, John; Dexter, Scott; Dittrich, David; Hvizdak, Erin

2011-06-01

This paper explores the growing concerns with computer science research, and in particular, computer security research and its relationship with the committees that review human subjects research. It offers cases that review boards are likely to confront, and provides a context for appropriate consideration of such research, as issues of bots, clouds, and worms enter the discourse of human subjects review.

Subjective thermal sensation and human body exergy consumption rate: analysis and correlation

DEFF Research Database (Denmark)

Simone, Angela; Dovjak, M.; Kolarik, Jakub

2011-01-01

, it is reasonable to consider both the exergy flows in building and those within the human body. There is a need to verify the human-body exergy model with the Thermal-Sensation (TS) response of subjects exposed to different combinations of indoor climate parameters (temperature, humidity, etc.). First results...... available on the relation between human-body exergy consumption rates and subjectively assessed thermal sensation showed that the minimum human body exergy consumption rate is associated with thermal sensation votes close to thermal neutrality, tending to slightly cool side of thermal sensation. By applying...... the exergy concept to the built indoor environment, additional results are going to be explored. By using the data available so far of operative temperature (to), the human body exergy consumption rates increase as to increases above 24°C or decreases below 22°C at relative humidity (RH) lower than 50...

The study of ground water movements about Guarani Aquifer system through Parana, Sao Paulo isotopes and Uruguay

International Nuclear Information System (INIS)

Da Rosa Filho, E.; Lima Bittendourt, A.; Chemas Hindt, E.; Duarte, U.; Montano, J.

2004-01-01

This study relates tectonic features to hydrochemistry properties in order to show an example where the Guarany Aquifer behaves like a closed compartiment. This situation can be used as a model to other localities with similar geological structures where the aquifer is not recharged by modern waters, therefore, groundwater withdrawal from deep wells depletes the aquifer turning its exploitation not recommended. This study area was located inside the limits of the Ponta Grossa Arch, especially by the the Rio Alonzo and Sao Jeronimo-Curiuva lineaments. Among the waters that had been already classified in Sao Paulo and Parana States (Brazil), predominate the calcium-bicarbonate and sodiumbicarbonate types and the characteristic of the water in this particular case is sodiumsulfate- chloride type with TDS above 1000 mg/L

Digital music exposure reliably induces temporary threshold shift in normal-hearing human subjects.

Science.gov (United States)

Le Prell, Colleen G; Dell, Shawna; Hensley, Brittany; Hall, James W; Campbell, Kathleen C M; Antonelli, Patrick J; Green, Glenn E; Miller, James M; Guire, Kenneth

2012-01-01

One of the challenges for evaluating new otoprotective agents for potential benefit in human populations is the availability of an established clinical paradigm with real-world relevance. These studies were explicitly designed to develop a real-world digital music exposure that reliably induces temporary threshold shift (TTS) in normal-hearing human subjects. Thirty-three subjects participated in studies that measured effects of digital music player use on hearing. Subjects selected either rock or pop music, which was then presented at 93 to 95 (n = 10), 98 to 100 (n = 11), or 100 to 102 (n = 12) dBA in-ear exposure level for a period of 4 hr. Audiograms and distortion product otoacoustic emissions (DPOAEs) were measured before and after music exposure. Postmusic tests were initiated 15 min, 1 hr 15 min, 2 hr 15 min, and 3 hr 15 min after the exposure ended. Additional tests were conducted the following day and 1 week later. Changes in thresholds after the lowest-level exposure were difficult to distinguish from test-retest variability; however, TTS was reliably detected after higher levels of sound exposure. Changes in audiometric thresholds had a "notch" configuration, with the largest changes observed at 4 kHz (mean = 6.3 ± 3.9 dB; range = 0-14 dB). Recovery was largely complete within the first 4 hr postexposure, and all subjects showed complete recovery of both thresholds and DPOAE measures when tested 1 week postexposure. These data provide insight into the variability of TTS induced by music-player use in a healthy, normal-hearing, young adult population, with music playlist, level, and duration carefully controlled. These data confirm the likelihood of temporary changes in auditory function after digital music-player use. Such data are essential for the development of a human clinical trial protocol that provides a highly powered design for evaluating novel therapeutics in human clinical trials. Care must be taken to fully inform potential subjects in

Hans Jonas' thought on the ethics of research on human subjects ...

African Journals Online (AJOL)

Hans Jonas' thought on the ethics of research on human subjects and its implications for contemporary medical research in Nigeria was examined. The thinking and teachings of Hans Jonas was on the need for medical research to advance beyond the use animals for research and experimentations to research on human ...

Determination of essential and toxic elements in sea bass (Centropomus sp.) and hake (Cynoscion leiarchus) consumed in the city of Sao Paulo by neutron activation analysis

International Nuclear Information System (INIS)

Fabiano, Karen C.; Moreira, Edson G.; Vasconcellos, Marina B.A.

2013-01-01

The goal was to use the Instrumental Neutron Activation Analysis (INAA) to evaluate the levels of essential and toxic elements in samples of hake (Cynoscion leiarchus) and sea bass (Centropomus sp.) that are most consumed fish in the town of some Sao Paulo. Ten specimens of hake and sea bass were acquired in Companhia de Entrepostos e Armazens Gerais de Sao Paulo (CEAGESP), main supply center for the population of the metropolitan area of Sao Paulo. After gutted and cleaned, the edible tissue was freeze-dried, ground and sieved. The elements were determined through the use of hyperpure germanium spectrometer after irradiation in the nuclear research reactor IEAR-1

Annual report 2007 - CPFL Energy - Light and Power Company from Sao Paulo, SP, Brazil

International Nuclear Information System (INIS)

2008-01-01

This document presents the balance of the economic, social, environmental performance of the Sao Paulo Light and Power Company (CPFL), during the year of 2007 as follows: highlights of 2007; profile of the CPFL Energy group; corporative performance; strategy of the company; performance in 2007 (the best year of the company); social responsibility

The Sao Jose do Rio Pardo mangeritic-granitic suite, south eastern Brazil

International Nuclear Information System (INIS)

Campos Neto, M.C.; Figueiredo, M.C.H.; Janasi, V.A.; Basei, M.A.S.; Fryer, B.J.

1988-01-01

In the Sao Jose do Rio Pardo region, Sao Paulo and Minas Gerais States, occur some intrusive, folded tabular bodies of mangerites associated with hornblende granitoids. The country rocks correspond to a complex association of gneisses and migmatites, locally with granulite facies assemblages. Both the magnerites and hornblende granitoids present a tectonic foliation with mineral flattening and stretching. Petrographically the mangeritic rocks are mainly dark green quartz mangerites with mesoperthite, plagioclase, quartz, hypersthene, clinopyroxene and variable amounts of hornblende, with zircon as conspicuous acessory. The pink hornblende granitoids are mainly granite s.s. exhibiting higher quartz and amphibole contents and lacking pyroxenes. Hololeucocratic alkali feldspar granites are locally associated to the hornblende granites. The textures of the mangerites and granites almost always show an important metamorphic overprinting, with relictic mesoperthite and pyroxene crystal into a granoblastic matrix. The magneritic-granitic suite is characterized by relatively high Fe/(Fe + Mg), K and HFS elements and low Ca contents, being comparable to typical anorogenic magneritic-granitic suites from Svcandinavia and North America. The Rb/Sr data indicate a Late Proterozoic metamorphic isotopic rehomogenization (930 Ma, Ro = 0.706). Geological evidence suggest that the intrusive age could be Middle Proterozoic, wich is reinforced by another Rb-Sr value of about 1300 Ma. (author) [pt

The electric energy consumption in the city of Sao Paulo - Brazil: the residential sector in the eighties; O consumo de energia eletrica na cidade de Sao Paulo: o setor residencial nos anos oitenta

Energy Technology Data Exchange (ETDEWEB)

Borelli, A.B.; Sellito, Y.M.; Moreira, J.G.S. [Sao Paulo Univ., SP (Brazil). Inst. de Eletrotecnica e Energia

1994-07-01

This work analyses the evolution of the energy consumption in the residential sector of the city of Sao Paulo in the years of 19980, 1985 and 1990, and relates electric power cost participation in the family monthly stratified budget. Also, the price x consumption elasticity verified in the mentioned period is analysed.

Phurcalite and others secondary uranium minerals from Perus, Sao Paulo, Brazil; Furcalita e outros minerais uraniferos secundarios de Perus, Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Atencio, D

1992-12-31

Phurcalite has been found filling fractures in the tourmaline-bearing granitic pegmatite of Perus, in the north-west part of Sao Paulo city, Brazil. It forms aggregates of radiating euhedral crystals up to 5 mm in length. The crystals are bright yellow, transparent and display vitreous to adamantine lustre. Its streak is pale yellow. Phurcalite is brittle, with a conchoidal fracture, and non-fluorescent. The crystal structure of phurcalite has been solves by single-crystal x-ray diffraction methods and refined to R = 3.8% using 2065 observed [I > 3{sigma}(I)] reflections. The structure consists of [(U O{sub 2}){sub 3} O{sub 2} (P O{sub 4}){sub 2} {sup 4n-}]{sub n} layers, parallel to (010), connected by Ca{sup 2+} ions and H{sub 2} O. The coordination polyhedra are: for U(1) hexagonal bi pyramid; for U(2) and U(3) pentagonal bi pyramids; for Ca(4) and Ca(5) capped trigonal prism and triangulated dodecahedron, respectively; and for P(6) and P(7) tetrahedra. As a consequence of this work, the molecular formula of phurcalite previously reported as Ca{sub 2} (U O{sub 2}){sub 3} (P O{sub 4}){sub 2} (OH){sub 4}.4 H{sub 2} O must be changed to Ca{sub 2} (U O{sub 2}){sub 3} O{sub 2} (P O{sub 4}){sub 2}.7 H{sub 2} O. Other secondary uranium minerals associated with Perus phurcalite are autunite, torbernite, meta-autunite, meta-torbernite, chernikovite, meta-uranocircite I, phosphuranylite, uranophane-alpha, uranophane-beta, haiweeite, barian week site and perhaps also bassetite, meta-tyuyamunite and meta-haiweeite. Opal, tridymite, cristobalite, secondary quartz, saponite and rhodochrosite occur associated to the uranium minerals. (author).

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects

Directory of Open Access Journals (Sweden)

Giordano Elena

2011-01-01

Full Text Available Abstract We have previously shown that krill oil (KO, more efficiently than fish oil, was able to downregulate the endocannabinoid system in different tissues of obese zucker rats. We therefore aimed at investigating whether an intake of 2 g/d of either KO or menhaden oil (MO, which provides 309 mg/d of EPA/DHA 2:1 and 390 mg/d of EPA/DHA 1:1 respectively, or olive oil (OO for four weeks, is able to modify plasma endocannabinoids in overweight and obese subjects. The results confirmed data in the literature describing increased levels of endocannabinoids in overweight and obese with respect to normo-weight subjects. KO, but not MO or OO, was able to significantly decrease 2-arachidonoylglycerol (2-AG, although only in obese subjects. In addition, the decrease of 2-AG was correlated to the plasma n-6/n-3 phospholipid long chain polyunsaturated fatty acid (LCPUFA ratio. These data show for the first time in humans that relatively low doses of LCPUFA n-3 as KO can significantly decrease plasma 2-AG levels in obese subjects in relation to decrease of plasma phospholipid n-6/n-3 LCPUFA ratio. This effect is not linked to changes of metabolic syndrome parameters but is most likely due to a decrease of 2-AG biosynthesis caused by the replacement of 2-AG ultimate precursor, arachidonic acid, with n-3 PUFAs, as previously described in obese Zucker rats.

The Gene Ontology (GO) Cellular Component Ontology: integration with SAO (Subcellular Anatomy Ontology) and other recent developments

Science.gov (United States)

2013-01-01

Background The Gene Ontology (GO) (http://www.geneontology.org/) contains a set of terms for describing the activity and actions of gene products across all kingdoms of life. Each of these activities is executed in a location within a cell or in the vicinity of a cell. In order to capture this context, the GO includes a sub-ontology called the Cellular Component (CC) ontology (GO-CCO). The primary use of this ontology is for GO annotation, but it has also been used for phenotype annotation, and for the annotation of images. Another ontology with similar scope to the GO-CCO is the Subcellular Anatomy Ontology (SAO), part of the Neuroscience Information Framework Standard (NIFSTD) suite of ontologies. The SAO also covers cell components, but in the domain of neuroscience. Description Recently, the GO-CCO was enriched in content and links to the Biological Process and Molecular Function branches of GO as well as to other ontologies. This was achieved in several ways. We carried out an amalgamation of SAO terms with GO-CCO ones; as a result, nearly 100 new neuroscience-related terms were added to the GO. The GO-CCO also contains relationships to GO Biological Process and Molecular Function terms, as well as connecting to external ontologies such as the Cell Ontology (CL). Terms representing protein complexes in the Protein Ontology (PRO) reference GO-CCO terms for their species-generic counterparts. GO-CCO terms can also be used to search a variety of databases. Conclusions In this publication we provide an overview of the GO-CCO, its overall design, and some recent extensions that make use of additional spatial information. One of the most recent developments of the GO-CCO was the merging in of the SAO, resulting in a single unified ontology designed to serve the needs of GO annotators as well as the specific needs of the neuroscience community. PMID:24093723

2.1 Man: subject of protection

International Nuclear Information System (INIS)

2004-01-01

This second chapter 'Man and environment' of the 7th state of the environment report of Austria describes the current situation of the protection of human health in terms of the European environmental policy and the main subjects of high relevance to it, such as air pollutants, water pollution, noise pollution, dangerous chemicals, food contamination, radiation protection, effects of climate change, plants, animal and habitats. (nevyjel)

Legal protection of the Guarani aquifer in Ribeirao Preto (Sao Paulo State, Brasil); Tutela juridica do Aquifero Guarani em Ribeirao Preto (Estado de Sao Paulo, Brasil)

Energy Technology Data Exchange (ETDEWEB)

Pedroso Goulart, M.; Cavalheiro Navajas Sampaio Campos, H.; Nepomuceno, O.

2012-11-01

The Guarani aquifer is one of the largest reservoirs of groundwater in the world and represents a strategic reserve for the four countries of South America where it occurs: Argentina, Brazil, Paraguay and Uruguay. The municipality of Ribeirao Preto, located in the north-east region of Sao Paulo, with a population of over 600,000 inhabitants, is supplied entirely by water from this aquifer. Hydrogeological studies reveal the existence of a large cone of drawdown in the centre of the city due to the intensive and indiscriminate use of water pumped out by wells for decades. In rural areas, where many of the rocky outcrops of the aquifer occur and which affords direct recharge by rain water, the risk of contamination by pesticides is of some concern. Over the years the Public Ministry of Sao Paulo in Ribeirao Preto has provided guidelines for actions and initiatives in environmental protection, especially with regard to the Guarani aquifer. These actions and initiatives are based mainly on the principle of the supremacy of public interest over private interest and the principle of caution. On the basis of these premises the prosecutor works with the government and the private sector to monitor and readmitted environmental liabilities that threaten the aquifer (landfills, diffuse contamination etc.) and to maintain due discipline within the activities that take place within the recharge zone (agriculture, industry and urbanization) including those of regulation and territorial planning. (Author)

Physicochemical characterization of ceramics from Sao Paulo II archaeological site

International Nuclear Information System (INIS)

Ribeiro, Rogerio Baria

2013-01-01

Archaeometry is a consolidated field with a wide application of nuclear analytical techniques for the characterization, protection, and restoration of archaeological pieces. This project aimed at studying the elementary chemical composition of 70 ceramic fragments samples from Sao Paulo II archaeological site, located along the Solimoes River channel, next to Coari city, in Brazilian Amazon. The characterization of samples was performed by neutron activation analysis (NAA). By the determination of 24 elements in the ceramic fragments ( Ce, Co, Cr, Cs, Eu, Fe, Hf, K, La, Lu, Na, Nd, Sb, Sm. Rb, Se, Ta, Tb, Th, U, Yb and Zn), it was possible to define groups of samples regarding the similarity/dissimilarity in elementary chemical composition. For such a task, the multivariate statistical methods employed were cluster analysis (C A), principal component analysis (PCA) and discriminant analysis (DA). Afterwards, seven ceramic fragments were selected based on the groups previously established, for the characterization of the site temporal horizon. Those ceramic fragments were analyzed by thermoluminescence (TL) and EPR for dating purposes. The firing temperatures were determined by electron paramagnetic resonance (EPR) technique, in order to infer about some aspects of the ceramic manufacture employed by the ancient peoples that lived in Sao Paulo 11. By the results obtained in this study, it was possible to identify the quantity of clay sources employed by the ceramists and the age of the ceramic pieces. Therefore, the results of this research may contribute to the study on the occupation dynamics in the pre-colonial Brazilian Amazon. (author)

Natural radionuclides and 137Cs in commercialized edible mushrooms in Sao Paulo-Brazil

International Nuclear Information System (INIS)

Castro, Lilian Pavanelli de

2008-01-01

Artificial and natural radionuclides are commonly found in several compartments of the earth's crust. Some mushroom species have a high capacity to absorb radionuclides and toxic elements from the soil. Diet is considered as one of the main routes of radioactive contamination. Therefore, radioactivity measurements in the environment and in food are extremely important to monitor the radiation levels that human can be exposed to either directly or indirectly. Environmental bio monitoring has demonstrated that diverse organisms such as crustaceans, fish and mushrooms are useful when evaluating both the contamination and the quality of the ecosystems. There are actually several radionuclides that can be accumulated in mushrooms, including 40 K, 137 Cs, 232 Th and 238 U. There are few studies in the Southern hemisphere countries, on the natural and artificial radioactivity levels in mushrooms. The present study evaluated 40 K, 137 Cs, 232 Th and 238 U in commercialized edible mushrooms in the state of Sao Paulo, Brazil. The edible mushroom samples were acquired in different commercial establishments in the Sao Paulo metropolitan region, specifically in Municipal Markets. Some samples were acquired directly from producers located in the cities of Mogi das Cruzes, Mirandopolis, Suzano and Juquitiba. About 400g were collected for each edible mushroom species, which included Agaricus sp, Pleurotus sp and Lentinula sp species. All the samples were prepared and stored in polyethylene bottles for approximately 35 days, so that secular equilibrium could be established before counting. The 40 K, 137 Cs, 232 Th and 238 U gamma activities were measured by gamma spectrometry. The equipment consisted of a Hyper pure Germanium detector connected to an electronic system. The detector efficiency was obtained from measurements of reference materials: IAEA-300, IAEA-327 and IAEA-375. The results for the specific activities in edible mushrooms samples ranged fi-om 461 to 1535 Bq kg -1

Environmental license process complexity in natural protected areas: case of OSBAT pipeline operated by TRANSPETRO in the state of Sao Paulo; Complexidade do licenciamento ambiental em areas naturais protegidas: caso do duto OSBAT operado pela TRANSPETRO no estado de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Alves, Anibal Jose Constantino; Raul, Vanderlei Lourenco; Martini, Andrea Dietrich; Campos, Cleber Lucio dos Santos; Ozorio, Tarcisio Faria; Melo Neto, Joao Evangelista de; Lima, Silvia Ferreira de [PETROBRAS Transporte S. A. (TRANSPETRO), Rio de Janeiro, RJ (Brazil)

2008-07-01

It presents the environmental license process enforced to obtain the Implementation License (LI) of the OSBAT pipeway part substitution, in the Sao Sebastiao city, State of Sao Paulo, with the analyses centered on the several public power instances and on the many special legal protection aspects around the natural area scenarios of the project interference. The license process had the duration of seventeen months, since the LI protocol and its emission. The process had the involvement of several organisms, the main part from the Sistema Nacional de Meio Ambiente - SISNAMA, and represented an interesting experience that can contribute to the agility of other license process of infrastructure works on protected natural areas, which has the incidence of an extensive legislation and activities restriction. (author)

Biomarkers of Dose and Effect of inhaled ozone in resting versus exercising human subjects: comparison with resting rats

Science.gov (United States)

Background: Human controlled exposure studies have generally focused on subjects exposed to ozone (O3) while exercising while exposures in rats have been done at rest. We exposed resting subjects to labeled O3 (18O3, 0.4 ppm, for 2 hr) and compared O3 dose and effects with our...

Conception of the Instrument Calibration Laboratory of Ionizing Radiation Measurement (LACIMRI) of CTMSP - Sao Paulo, SP; Concepcao do Laboratorio de Calibracao de Instrumentos de Medicao de Radiacao Ionizante (LACIMRI) do CTMSP, Sao Paulo, SP

Energy Technology Data Exchange (ETDEWEB)

Silva, Raimundo Dias da; Kibrit, Eduardo, E-mail: raimundo@ctmsp.mar.mil.b, E-mail: kibrit@ctmsp.mar.mil.b [Centro Tecnologico da Marinha em Sao Paulo (CTMSP), Sao Paulo, SP (Brazil)

2009-07-01

The present work describes the phases of implantation of calibration laboratory of ionizing radiation measurement instruments at the CTMSP, Sao Paulo, in a priory approved by CNEN, Brazil. That laboratory will allow and enhance the present metrological capacity for the attendance to the growing demand for calibration services of the instruments

Archaeometric studies of ceramics from the Sao Paulo II archaeological site

International Nuclear Information System (INIS)

Rogerio Baria; Munita, C.S.; Cano, N.F.; Tatumi, S.H.; Silva-Carrera, B.N.; Shigueo Watanabe; Neves, E.G.

2015-01-01

This paper aims at studying the elementary chemical composition of 70 ceramic fragments from the Sao Paulo II archaeological site by instrumental neutron activation analysis. The concentration data was studied next using multivariate statistical methods, such as cluster analysis, principal component analysis and discriminant analysis. The results showed three different chemical groups of samples regarding the similarity/dissimilarity between the samples. Ceramics from each group have been selected and dated using thermoluminescence. The firing temperature of the ceramics was determined by electron paramagnetic resonance. (author)

The Patient-Worker: A Model for Human Research Subjects and Gestational Surrogates.

Science.gov (United States)

Ryman, Emma; Fulfer, Katy

2017-01-13

We propose the 'patient-worker' as a theoretical construct that responds to moral problems that arise with the globalization of healthcare and medical research. The patient-worker model recognizes that some participants in global medical industries are workers and are owed worker's rights. Further, these participants are patient-like insofar as they are beneficiaries of fiduciary relationships with healthcare professionals. We apply the patient-worker model to human subjects research and commercial gestational surrogacy. In human subjects research, subjects are usually characterized as either patients or as workers. Through questioning this dichotomy, we argue that some subject populations fit into both categories. With respect to commercial surrogacy, we enrich feminist discussions of embodied labor by describing how surrogates are beneficiaries of fiduciary obligations. They are not just workers, but patient-workers. Through these applications, the patient-worker model offers a helpful normative framework for exploring what globalized medical industries owe to the individuals who bear the bodily burdens of medical innovation. © 2017 John Wiley & Sons Ltd.

The SAO and Kelvin waves in the EuroGRIPS GCMS and the UK Met. Office analyses

Directory of Open Access Journals (Sweden)

M. Amodei

Full Text Available We compare the tropical oscillations and planetary scale Kelvin waves in four troposphere-stratosphere climate models and the assimilated dataset produced by the United Kingdom Meteorological Office (UKMO. The comparison has been made in the GRIPS framework "GCM-Reality Intercomparison Project for SPARC", where SPARC is Stratospheric Processes and their Role in Climate, a project of the World Climate Research Program. The four models evaluated are European members of GRIPS: the UKMO Unified Model (UM, the model of the Free University in Berlin (FUB–GCM, the ARPEGE-climat model of the French National Centre for Meteorological Research (CNRM, and the Extended UGAMP GCM (EUGCM of the Centre for Global Atmospheric Modelling (CGAM. The integrations were performed with different, but annually periodic external conditions (e.g., sea-surface temperature, sea ice, and incoming solar radiation. The structure of the tropical winds and the strengths of the Kelvin waves are examined. In the analyses where the SAO (Semi-Annual Oscillation and the QBO (Quasi-Biennal Oscillation are reasonably well captured, the amplitude of these analysed Kelvin waves is close to that observed in independent data from UARS (Upper Atmosphere Research Satellite. In agreement with observations, the Kelvin waves generated in the models propagate into the middle atmosphere as wave packets, consistent with a convective forcing origin. In three of the models, slow Kelvin waves propagate too high and their amplitudes are overestimated in the upper stratosphere and in the mesosphere, the exception is the UM which has weaker waves. None of the modelled waves are sufficient to force realistic eastward phases of the QBO or SAO. Although the SAO is represented by all models, only two of them are able to generate westerlies between 10 hPa and 50 hPa. The importance of the role played in the SAO by unresolved gravity waves is emphasized. Although it exhibits some unrealistic features, the

The SAO and Kelvin waves in the EuroGRIPS GCMS and the UK Met. Office analyses

Directory of Open Access Journals (Sweden)

M. Amodei

2001-01-01

Full Text Available We compare the tropical oscillations and planetary scale Kelvin waves in four troposphere-stratosphere climate models and the assimilated dataset produced by the United Kingdom Meteorological Office (UKMO. The comparison has been made in the GRIPS framework "GCM-Reality Intercomparison Project for SPARC", where SPARC is Stratospheric Processes and their Role in Climate, a project of the World Climate Research Program. The four models evaluated are European members of GRIPS: the UKMO Unified Model (UM, the model of the Free University in Berlin (FUB–GCM, the ARPEGE-climat model of the French National Centre for Meteorological Research (CNRM, and the Extended UGAMP GCM (EUGCM of the Centre for Global Atmospheric Modelling (CGAM. The integrations were performed with different, but annually periodic external conditions (e.g., sea-surface temperature, sea ice, and incoming solar radiation. The structure of the tropical winds and the strengths of the Kelvin waves are examined. In the analyses where the SAO (Semi-Annual Oscillation and the QBO (Quasi-Biennal Oscillation are reasonably well captured, the amplitude of these analysed Kelvin waves is close to that observed in independent data from UARS (Upper Atmosphere Research Satellite. In agreement with observations, the Kelvin waves generated in the models propagate into the middle atmosphere as wave packets, consistent with a convective forcing origin. In three of the models, slow Kelvin waves propagate too high and their amplitudes are overestimated in the upper stratosphere and in the mesosphere, the exception is the UM which has weaker waves. None of the modelled waves are sufficient to force realistic eastward phases of the QBO or SAO. Although the SAO is represented by all models, only two of them are able to generate westerlies between 10 hPa and 50 hPa. The importance of the role played in the SAO by unresolved gravity waves is emphasized. Although it exhibits some unrealistic features, the

Control and instrumentation system of the Zero Power Reactor at IEA, Sao Paulo (Brazil)

International Nuclear Information System (INIS)

Peluso, M.A.V.; Matsuda, K.; Hukai, R.

1974-01-01

The control and instrumentation system of the Zero Power Reactor at the IEA (Institute of Atomic Energy - Sao Paulo, Brazil) is described. Technical specifications of the main items of equipment are presented in a general way. Information is also given on the connection between the system described and the electrical supply system of the IEA reactor physics laboratory [pt

Mineralogical characterization of historical portuguese wall tiles of Sao Luis, Maranhao, Brazil; Caracterizacao mineralogica de azulejos portugueses do Centro Historico de Sao Luis do Maranhao

Energy Technology Data Exchange (ETDEWEB)

Rivas Mercury, J.M.; Vasconcelos, N.S.L.S.; Cabral, A.A., E-mail: rivascefetma@gmail.co [Instituto Federal de Educacao, Ciencia e Tecnologia do Maranhao (IFMA), Sao Luis, MA (Brazil). Programa de Mestrado em Engenharia de Materiais; Pereira, D.J. Costa [Centro de Criatividade Odylo Costa Filho (SECMA), Sao Luis, MA (Brazil). Centro Historico; Angelica, R.S. [Universidade Federal do Para (CG/UFPA), Belem, PA (Brazil). Inst. de Geociencias

2010-07-01

Portuguese wall tiles from centuries, XVII, XVIII and XIX, found in Sao Luis Maranhao has been studied by X-ray diffraction, in order to interpret the possible raw material and burning temperature. The mineral phases, Quartz, Wollastonite, Calcite and Gehlenite were identified in all samples. Based on the results it is possible to affirm that the main raw materials used to manufacture this materials was probably mixtures of kaolinite clay and calcite. Based on the mineralogical information it was also possible to state that burning temperature of this wall tiles was lower than 1000 deg C. (author)

Alterações cognitivas na SAOS Cognitive impairment in obstructive sleep apnea syndrome

Directory of Open Access Journals (Sweden)

Pedro Felipe Carvalhedo de Bruin

2010-06-01

Full Text Available Alterações da cognição e do desempenho estão bem estabelecidas em pacientes com SAOS, causando um impacto significativo sobre a qualidade de vida e o risco de acidentes nesses indivíduos. Tais alterações são mais profundas nos quadros mais graves de SAOS, o que explica a aparente discrepância na frequência e gravidade desse prejuízo entre estudos com pacientes de clínicas de sono e estudos de base populacional. Vários aspectos podem estar comprometidos, incluindo o processamento cognitivo, a atenção sustentada, as funções executivas e a memória. Entretanto, os mecanismos causais desses déficits não estão inteiramente elucidados, e existem controvérsias, particularmente em relação à contribuição relativa da hipóxia intermitente e da interrupção do sono presentes na SAOS. O impacto da sonolência diurna sobre o desempenho desses pacientes nos diversos testes cognitivos também ainda deve ser determinado, assim como o possível efeito de comorbidades frequentes, incluindo o diabete melito, a hipertensão arterial sistêmica, a doença cardiovascular e a obesidade. Existem evidências convincentes de que o tratamento com CPAP produz uma significativa melhora do desempenho e da cognição, sobretudo nos portadores de SAOS moderada e grave, embora sejam necessários mais estudos acerca do seu impacto a longo prazo.Cognitive and performance impairment is well established in patients with obstructive sleep apnea syndrome (OSAS, having a significant impact on the quality of life and the risk of accidents in these individuals. The severity of the impairment correlates with that of the OSAS, which explains the apparent discrepancy between studies using patients from sleep clinics and population-based studies in terms of the reported frequency and severity of such impairment. Cognitive processing, sustained attention, executive functioning, and memory have all been reported to be impaired in OSAS. However, the causal

Differential effects of airway anesthesia on ozone-induced pulmonary responses in human subjects.

Science.gov (United States)

Schelegle, E S; Eldridge, M W; Cross, C E; Walby, W F; Adams, W C

2001-04-01

We examined the effect of tetracaine aerosol inhalation, a local anesthetic, on lung volume decrements, rapid shallow breathing, and subjective symptoms of breathing discomfort induced by the acute inhalation of 0.30 ppm ozone for 65 min in 22 ozone-sensitive healthy human subjects. After 50 min of ozone inhalation FEV(1) was reduced 24%, breathing frequency was increased 40%, tidal volume was decreased 31%, and total subjective symptom score was increased (71.2, compared with 3.8 for filtered air exposure). Inhalation of tetracaine aerosol resulted in marked reductions in ozone-induced subjective symptoms of throat tickle and/or irritation (92.1%), cough (78.5%), shortness of breath (72.5%), and pain on deep inspiration (69.4%). In contrast, inhalation of tetracaine aerosol (mass median aerodynamic diameter of 3.52 microm with a geometric standard deviation of 1.92) resulted in only minor and inconsistent rectification of FEV(1) decrements (5.0%) and breathing frequency (-3.8%) that was not significantly different from that produced by saline aerosol alone (FEV(1), 5.1% and breathing frequency, -2.7%). Our data are consistent with afferent endings located within the large conducting airways of the tracheobronchial tree being primarily responsible for ozone-induced subjective symptoms and provides strong evidence that ozone-induced inhibition of maximal inspiratory effort is not dependent on conscious sensations of inspiratory discomfort.

Density profile and cholesterol concentration of serum lipoproteins in experimental animals and human subjects on hypercholesterolaemic diets

NARCIS (Netherlands)

Beynen, A.C.; Terpstra, A.H.M.

1984-01-01

1. 1. The density profile of Sudan black stained serum lipoproteins was studied in human subjects and various animal species on diets supplemented with cholesterol. 2. 2. In the animals studied (rabbits, calves, mice, chickens, rats and guinea-pigs), the feeding of cholesterol resulted in an

75 FR 62738 - Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides...

Science.gov (United States)

2010-10-13

... addressed in EPA science and ethics reviews of proposed and completed human research for pesticides, based... Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides; Notification to... protection of human subjects of research that apply to third parties who conduct or support research for...

Atmospheric element pollutant evaluation at the Sao Paulo University campus, Sao Paulo using Canoparmelia texana Lichen species

Energy Technology Data Exchange (ETDEWEB)

Rocha, Rosiana R.; Saiki, Mitiko, E-mail: rosianarocha@yahoo.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2015-07-01

The use of lichens as biomonitors of atmospheric pollutants has been considered as a very suitable tool when compared to conventional methods of direct measurements. Lichens in particular are widely used as biomonitors due to its easy sampling, low cost and resistance to environmental stresses. In this study, neutron activation analysis (NAA) was applied for element determinations in Canoparmelia texana lichenized fungi species. The samples were collected from tree barks in different sites at the Sao Paulo University Campus and in sites of areas considered non-polluted. Comparisons were made between the element concentration obtained in lichen from the study area and those from non-polluted sites. Results indicated that lichens from study area presented higher concentrations of As, Br, Ca, Cd, Co, Cr, Cs, Fe, K, La, Rb, Sb, Se and U than clean areas. The principal components analysis (PCA) was applied to the results obtained and five principal components were found as being responsible for almost 77 % of the variance. These findings suggest that element pollutants found may be associated with vehicular emissions, construction of buildings and metallurgical activities. (author)

Atmospheric element pollutant evaluation at the Sao Paulo University campus, Sao Paulo using Canoparmelia texana Lichen species

International Nuclear Information System (INIS)

Rocha, Rosiana R.; Saiki, Mitiko

2015-01-01

The use of lichens as biomonitors of atmospheric pollutants has been considered as a very suitable tool when compared to conventional methods of direct measurements. Lichens in particular are widely used as biomonitors due to its easy sampling, low cost and resistance to environmental stresses. In this study, neutron activation analysis (NAA) was applied for element determinations in Canoparmelia texana lichenized fungi species. The samples were collected from tree barks in different sites at the Sao Paulo University Campus and in sites of areas considered non-polluted. Comparisons were made between the element concentration obtained in lichen from the study area and those from non-polluted sites. Results indicated that lichens from study area presented higher concentrations of As, Br, Ca, Cd, Co, Cr, Cs, Fe, K, La, Rb, Sb, Se and U than clean areas. The principal components analysis (PCA) was applied to the results obtained and five principal components were found as being responsible for almost 77 % of the variance. These findings suggest that element pollutants found may be associated with vehicular emissions, construction of buildings and metallurgical activities. (author)

The human subject in the organization

Directory of Open Access Journals (Sweden)

Marcela Pérez Pazmiño

2015-12-01

Full Text Available This article puts the human subject into the center of the discussion, by finding common factors of representative authors in the field, revealing what was their predominant concern. From the Weberian bureaucratic tradition, organizational theory has witnessed that economic target was in the very center of organizations. For current assumptions, legitimate forms of domination would be substantiated by the inability to resolve most everyday affairs, those that handle to the rentability. It starts to show that organizations, far from being a rational set of actions, are places of unsound decisions, most often used for personal than community goals. The conclusion brings a new topic of discussion for organizational theory: the concept of a free agent within the organization.

The effect of feeding frequency on insulin and ghrelin responses in human subjects

DEFF Research Database (Denmark)

Solomon, Thomas; Chambers, Edward S; Jeukendrup, Asker E

2008-01-01

Recent work shows that increased meal frequency reduces ghrelin responses in sheep. Human research suggests there is an interaction between insulin and ghrelin. The effect of meal frequency on this interaction is unknown. Therefore, we investigated the effect of feeding frequency on insulin...... and ghrelin responses in human subjects. Five healthy male volunteers were recruited from the general population: age 24 (SEM 2)years, body mass 75.7 (SEM 3.2) kg and BMI 23.8 (SEM 0.8) kg/m(2). Volunteers underwent three 8-h feeding regimens: fasting (FAST); low-frequency(two) meal ingestion (LOFREQ......(MEAL)); high-frequency (twelve) meal ingestion (HIFREQ(MEAL)). Meals were equi-energetic within trials,consisting of 64% carbohydrate, 23% fat and 13% protein. Total energy intake was equal between feeding trials. Total area under the curve for serum insulin and plasma ghrelin responses did not differ between...

Human subjects protection training for community workers: an example from "Faith Moves Mountains".

Science.gov (United States)

Hatcher, Jennifer; Schoenberg, Nancy E

2007-01-01

Despite widespread agreement on the necessity of protecting human subjects, questions regarding ethical treatment and protection of human subjects remain and are particularly vexing for community-based participatory research (CBPR). There has been a notable lack of attention paid to what type of training should be provided and how to balance "real-life" concerns with official requirements. The purpose of this article is to demonstrate how, in consultation with the Office of Research Integrity (ORI) at our institution and our community partners, we developed training that overcame concerns related to instruction of community workers on protection of human subjects. We developed a training module written in lay terms and containing only information pertinent to non-key personnel and their role in the CBPR project. We designed and piloted this material in collaboration with our community partners who work with us to recruit and train lay health advisors (LHAs) and oversee the day-to-day operations of the CBPR project. The educational module was presented to the community workers as a part of a day-long training session. The written materials were a part of a notebook of information accompanied by an oral Power Point presentation. Each of the workers was given a written test to evaluate knowledge of the content presented. The test was administered by the project director, a community member herself, and then sent to our institution for grading by personnel not involved in this project. To date, all community workers have passed the written test. The community members, research partners, and the ORI are satisfied with the scope and simplicity of the training program developed. Our team's collaborative approach to community-based human subjects training contributes to advancing a grounded, feasible, and rigorous process of protecting human subjects while implementing CBPR ideals.

Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein (a levels in human subjects with rheumatoid diseases.

Directory of Open Access Journals (Sweden)

Olaf Schultz

2010-12-01

Full Text Available Interleukin-6 (IL-6 is a pro-inflammatory cytokine that has been found to be increased in type 2 diabetic subjects. However, it still remains unclear if these elevated IL-6 levels are co-incidental or if this cytokine is causally related to the development of insulin resistance and type 2 diabetes in humans. Therefore, in the present study we examined insulin sensitivity, serum adipokine levels and lipid parameters in human subjects before and after treatment with the IL-6 receptor antibody Tocilizumab.11 non-diabetic patients with rheumatoid disease were included in the study. HOMA-IR was calculated and serum levels for leptin, adiponectin, triglycerides, LDL-cholesterol, HDL-cholesterol and lipoprotein (a (Lp (a were measured before as well as one and three months after Tocilizumab treatment. The HOMA index for insulin resistance decreased significantly. While leptin concentrations were not altered by inhibition of IL-6 signalling, adiponectin concentrations significantly increased. Thus the leptin to adiponectin ratio, a novel marker for insulin resistance, exhibited a significant decrease. Serum triglycerides, LDL-cholesterol and HDL-cholesterol tended to be increased whereas Lp (a levels significantly decreased.Inhibition of IL-6 signalling improves insulin sensitivity in humans with immunological disease suggesting that elevated IL-6 levels in type 2 diabetic subjects might be causally involved in the pathogenesis of insulin resistance. Furthermore, our data indicate that inhibition of IL-6 signalling decreases Lp (a serum levels, which might reduce the cardiovascular risk of human subjects.

Human autonomic rhythms: vagal cardiac mechanisms in tetraplegic subjects

Science.gov (United States)

Koh, J.; Brown, T. E.; Beightol, L. A.; Ha, C. Y.; Eckberg, D. L.

1994-01-01

1. We studied eight young men (age range: 20-37 years) with chronic, clinically complete high cervical spinal cord injuries and ten age-matched healthy men to determine how interruption of connections between the central nervous system and spinal sympathetic motoneurones affects autonomic cardiovascular control. 2. Baseline diastolic pressures and R-R intervals (heart periods) were similar in the two groups. Slopes of R-R interval responses to brief neck pressure changes were significantly lower in tetraplegic than in healthy subjects, but slopes of R-R interval responses to steady-state arterial pressure reductions and increases were comparable. Plasma noradrenaline levels did not change significantly during steady-state arterial pressure reductions in tetraplegic patients, but rose sharply in healthy subjects. The range of arterial pressure and R-R interval responses to vasoactive drugs (nitroprusside and phenylephrine) was significantly greater in tetraplegic than healthy subjects. 3. Resting R-R interval spectral power at respiratory and low frequencies was similar in the two groups. During infusions of vasoactive drugs, low-frequency R-R interval spectral power was directly proportional to arterial pressure in tetraplegic patients, but was unrelated to arterial pressure in healthy subjects. Vagolytic doses of atropine nearly abolished both low- and respiratory-frequency R-R interval spectral power in both groups. 4. Our conclusions are as follows. First, since tetraplegic patients have significant levels of low-frequency arterial pressure and R-R interval spectral power, human Mayer arterial pressure waves may result from mechanisms that do not involve stimulation of spinal sympathetic motoneurones by brainstem neurones. Second, since in tetraplegic patients, low-frequency R-R interval spectral power is proportional to arterial pressure, it is likely to be mediated by a baroreflex mechanism. Third, since low-frequency R-R interval rhythms were nearly abolished

Geology and petrology of alkaline Massif from Ilha de Vitoria, Sao Paulo State

International Nuclear Information System (INIS)

Motoki, A.

1986-01-01

Geological and petrological studies of the Vitoria Island Alkaline Complex, State of Sao Paulo, have been carried out by means of photo interpretation; field work, thin section studies, whole-rock chemical analysis, x-ray diffractometry, EPMA mineral analysis, and K-Ar and Rb-Sr dating. Radiometric dating indicates a late Cretaceous age for the Vitoria Island Alkaline Complex, which is concordant with the ages of other neighbouring alkaline bodies. (author)

Digital music exposure reliably induces temporary threshold shift (TTS) in normal hearing human subjects

Science.gov (United States)

Le Prell, C. G.; Dell, S.; Hensley, B.; Hall, J. W.; Campbell, K. C. M.; Antonelli, P. J.; Green, G. E.; Miller, J. M.; Guire, K.

2012-01-01

Objectives One of the challenges for evaluating new otoprotective agents for potential benefit in human populations is availability of an established clinical paradigm with real world relevance. These studies were explicitly designed to develop a real-world digital music exposure that reliably induces temporary threshold shift (TTS) in normal hearing human subjects. Design Thirty-three subjects participated in studies that measured effects of digital music player use on hearing. Subjects selected either rock or pop music, which was then presented at 93–95 (n=10), 98–100 (n=11), or 100–102 (n=12) dBA in-ear exposure level for a period of four hours. Audiograms and distortion product otoacoustic emissions (DPOAEs) were measured prior to and after music exposure. Post-music tests were initiated 15 min, 1 hr 15 min, 2 hr 15 min, and 3 hr 15 min after the exposure ended. Additional tests were conducted the following day and one week later. Results Changes in thresholds after the lowest level exposure were difficult to distinguish from test-retest variability; however, TTS was reliably detected after higher levels of sound exposure. Changes in audiometric thresholds had a “notch” configuration, with the largest changes observed at 4 kHz (mean=6.3±3.9dB; range=0–13 dB). Recovery was largely complete within the first 4 hours post-exposure, and all subjects showed complete recovery of both thresholds and DPOAE measures when tested 1-week post-exposure. Conclusions These data provide insight into the variability of TTS induced by music player use in a healthy, normal-hearing, young adult population, with music playlist, level, and duration carefully controlled. These data confirm the likelihood of temporary changes in auditory function following digital music player use. Such data are essential for the development of a human clinical trial protocol that provides a highly powered design for evaluating novel therapeutics in human clinical trials. Care must be

Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.

Directory of Open Access Journals (Sweden)

Emmanuel S Onaivi

Full Text Available BACKGROUND: Addiction and major depression are mental health problems associated with stressful events in life with high relapse and reoccurrence even after treatment. Many laboratories were not able to detect the presence of cannabinoid CB2 receptors (CB2-Rs in healthy brains, but there has been demonstration of CB2-R expression in rat microglial cells and other brain associated cells during inflammation. Therefore, neuronal expression of CB2-Rs had been ambiguous and controversial and its role in depression and substance abuse is unknown. METHODOLOGY/PRINCIPAL FINDINGS: In this study we tested the hypothesis that genetic variants of CB2 gene might be associated with depression in a human population and that alteration in CB2 gene expression may be involved in the effects of abused substances including opiates, cocaine and ethanol in rodents. Here we demonstrate that a high incidence of (Q63R but not (H316Y polymorphism in the CB2 gene was found in Japanese depressed subjects. CB2-Rs and their gene transcripts are expressed in the brains of naïve mice and are modulated following exposure to stressors and administration of abused drugs. Mice that developed alcohol preference had reduced CB2 gene expression and chronic treatment with JWH015 a putative CB2-R agonist, enhanced alcohol consumption in stressed but not in control mice. The direct intracerebroventricular microinjection of CB2 anti-sense oligonucleotide into the mouse brain reduced mouse aversions in the plus-maze test, indicating the functional presence of CB2-Rs in the brain that modifies behavior. We report for the using electron microscopy the sub cellular localization of CB2-Rs that are mainly on post-synaptic elements in rodent brain. CONCLUSIONS/SIGNIFICANCE: Our data demonstrate the functional expression of CB2-Rs in brain that may provide novel targets for the effects of cannabinoids in depression and substance abuse disorders beyond neuro-immunocannabinoid activity.

Deuterium and oxygen-18 concentrations in rain and river waters from Minas Gerais, Sao Paulo and Parana States, Brazil; Concentracoes de deuterio e oxigenio-18 nas aguas de precipitacao e de superficie dos Estados de Minas Gerais, Sao Paulo e Parana

Energy Technology Data Exchange (ETDEWEB)

Vieira, Oliveiro J [Escola Superior de Agricultura de Lavras, MG (Brazil); Salati, Eneas [Sao Paulo Univ., Piracicaba, SP (Brazil). Escola Superior de Agricultura Luiz de Queiroz

1982-07-01

The main object of this paper was to study the concentration of deuterium (D) and Oxygen-18 ({sup 18} O) in the rain and river waters from the States of Minas Gerais, Sao paulo and Parana. Monthly samples were prepared and analysed at the Centro de Energia Nuclear na Agricultura (CENA-ESALQ-USP) with the use of CH-4 ({sup 18} O) and GD-150 (D) mass spectrometers of Varian-Mat. In order to correlate the D and {sup 18} O of the rain water the equation {delta}D = 9.22 + 7.17{delta}18 was found. Considering the three equations separately it was observed that the parameter a = {delta}D -b{delta}18 increases from the South to the North. For the Piracicaba River (city of Piracicaba only), the D and {sup 18} O relationship was expressed by {delta}D = -10.98 + 4.88{delta}18. The States of Minas Gerais and Sao Paulo can be divided according to the weight-average concentrations ({delta}18 m%{sub 0}). This division is not possible from Parana. Considering the average from the weight average concentration (annually and summer) for the three States, the annual average (D and {sup 18} O) is slightly richer than the summer average, showing the importance of the amount effect, mainly for the States of Minas Gerais and Sao Paulo. The rivers studied had little variation in the {sup 18} O concentrations with no definite periodicity. The rivers from the North of Minas Gerais are slightly richer in {sup 18} O than the rivers from the South. The waters from Rio Grande in the South of Minas Gerais State are poorer in {sup 18} O than the water of the same river in the `Triangle`region. The {delta}18% {sub 0} data for the rivers Grande, Parnaiba and Parana are very similar, so there is no way to compute the contribution of the first and the second rivers in the formation of the third. (author). 20 refs., 2 figs., 8 tabs.

Geology and geochronology of Cardoso Island, in the southeastern coast of Sao Paulo State

International Nuclear Information System (INIS)

Weber, Werner

1998-01-01

This aim of work is the geological and geochronological study of rocks cropping out on Cardoso Island, on the southeastern coast of Sao Paulo States, close to be boundary with Parana State. The Island with an area of about 151 km 2 is a protected area administered by the Forest Institute of Environment Secretariat of the State of Sao Paulo. It is mountanious, with a peak at 814 m, and is covered by dense Mata Atlantica vegetation. The terrains which compose the island are mainly an igneous complex with light grey leucocratic, inequigranular, medium - to coarse-grained syenites. The predominant Tres Irmaos Syenite (STI), composed of pyroxene, hornblende, and perthitic to mesoperthitic microcline, has a magmatic flow structures, and is cut by the Cambriu alkali-feldspar Granites (GC), which is pinkish grey, leucocratic and medium-grained. Geochemical analysis of STI and GC demonstrate their meta luminous alkaline nature and late-orogenic to an orogenic character. The geochronological results suggest that the bodies were formed between 620 and 570 My according to the U-Pb method in zircons, with cooling between 597 and 531 My (K-Ar in amphiboles). Whole rock Sm-Nd analysis yield T DM ages in the Meso and Paleoproterozoic (1.200 - 2.200 My). belt of low grade meta sedimentary rocks occurs in the northern part of the island. Quartz schist, quartz-mica schist and mica-quartz schist, often containing andaluzite and cordierite, predominate. The geochemical and geochronological data suggest that the sources of the metasediments were andesites of continental arc whose protolities separated from the mantle during the Paleoproterozoic, between 1.800 and 2.200 My. These metasediments probably continue on the continent in the Taquari region and extend southwards in narrow strips between the granitoids of the Paranagua Domain. Although quaternary deposits are expressive, they were not studied in details since they were not the objectives of this study. (author)

Measurements of Po214 at Sao Jose dos Campos and Cachoeira Paulista: correlation with meteorological data

International Nuclear Information System (INIS)

Marinho, E.V.A.; Nordemann, D.J.R.

1985-01-01

PO 214 , a short life daughter product of RN 222 , was measured by alpha-ray spectrometry of a atmospheric particles sampled on Millipore filters (0.8 μm pore) at Sao Jose dos Campos (23 0 12'S, 45 0 51'W) and Cachoeira Paulista (22 0 41'S, 45 0 00'W). The infleunce of rainfall on the atmospheric Po 214 was studied at Sao Jose dos Campos. The mean activity was 98 pCi/m 3 for dry days (without rain during the preceding two days). On the contrary a low mean activity of 35 pCi/m 3 was observed for high pluviometry days from 08/30 to 10/26 for which total rainfall was 365.5 mm. At Cachoeria Paulista the Po 214 activity was correlated with the stability of the air (measured by the Richardson number), showing an accumaltion of natural radioactive aerosols during periods of higher stability of the lower atmosphere. (author) [pt

Thermal modeling and geomorphology of the south border of the Sao Francisco Craton: thermochronology by fission tracks in apatites;Modelagem termica e geomorfologia da borda sul do Craton do Sao Francisco: termocronologia por tracos de fissao em apatita

Energy Technology Data Exchange (ETDEWEB)

Hackspacher, Peter Christian [UNESP, Rio Claro, SP (Brazil). Inst. de Geociencias e Ciencias Exatas; Godoy, Daniel Francoso de; Franco, Ana Olivia Barufi [UNESP, Rio Claro, SP (Brazil). Pos-Graduacao em Geologia Regional; Ribeiro, Luiz Felipe Brandini [NUCLEARGEO, Rio Claro, SP (Brazil); Hadler Neto, Julio Cesar [Universidade Estadual de Campinas (IFGW/UNICAMP), SP (Brazil). Inst. de Fisica Gleb Wataghin

2007-12-15

Recent developments in Fission Track thermochronology associated to mesozoic-cenozoic erosion and tectonic presented trough thematic maps (isotemperature), permit to model the landscape evolution in the southern border of the Sao Francisco craton, southeastern Brazil. Paleotemperature, obtained by fission track analysis in apatite, is closely related to geomorphologic interpretations. The area suffered a complex imprint of endogenous and exogenous processes resulting diversified and differentiated relieves. The landscape is strongly controlled by exhumation between Jurassic and Lower Cretaceous, uplift with tectonic denudation related to crustal heating at the Upper Cretaceous and reactivation of faults until the Miocene. This scenario is a result of reactivations of different brittle structures that accommodate the deformation in the southern border of the Sao Francisco craton. The landscape reflects denudations of up to 3 km with preserved remains of erosive surfaces in the topographical tops and chronocorrelates deposits in the basins of the region. (author)

Human Subjects Protection: A Source for Ethical Service-Learning Practice

Science.gov (United States)

Wendler, Rachael

2012-01-01

Human subjects research ethics were developed to ensure responsible conduct when university researchers learn by interacting with community members. As service-learning students also learn by interacting with community members, a similar set of principles may strengthen the ethical practice of service-learning. This article identifies ethical…

Acquisition of anoikis resistance in human osteosarcoma cells does not alter sensitivity to chemotherapeutic agents

International Nuclear Information System (INIS)

Díaz-Montero, C Marcela; McIntyre, Bradley W

2005-01-01

Chemotherapy-induced cell death can involve the induction of apoptosis. Thus, aberrant function of the pathways involved might result in chemoresistance. Since cell adhesion to the extracellular matrix acts as a survival factor that homeostatically maintains normal tissue architecture, it was tested whether acquisition of resistance to deadhesion-induced apoptosis (anoikis) in human osteosarcoma would result in resistance to chemotherapy. Osteosarcoma cell lines (SAOS-2 and TE-85) obtained from ATCC and were maintained in complete Eagle's MEM medium. Suspension culture was established by placing cells in tissue culture wells coated with poly-HEMA. Cell cytotoxicity was determined using a live/dead cytotoxicity assay. Cell cycle/apoptosis analyses were performed using propidium iodide (PI) staining with subsequent FACS analysis. Apoptosis was also assayed by Annexin-FITC/PI staining. Etoposide, adriamycin, vinblastine, cisplatin and paclitaxel were able to induce apoptosis in human osteosarcoma cells SAOS-2 regardless of their anoikis resistance phenotype or the culture conditions (adhered vs. suspended). Moreover, suspended anoikis resistant TE-85 cells (TE-85ar) retained their sensitivity to chemotherapy as well. Acquisition of anoikis resistance in human osteosarcoma cells does not result in a generalized resistance to all apoptotic stimuli, including chemotherapy. Moreover, our results suggest that the pathways regulating anoikis resistance and chemotherapy resistance might involve the action of different mediators

Acquisition of anoikis resistance in human osteosarcoma cells does not alter sensitivity to chemotherapeutic agents

Directory of Open Access Journals (Sweden)

McIntyre Bradley W

2005-04-01

Full Text Available Abstract Background Chemotherapy-induced cell death can involve the induction of apoptosis. Thus, aberrant function of the pathways involved might result in chemoresistance. Since cell adhesion to the extracellular matrix acts as a survival factor that homeostatically maintains normal tissue architecture, it was tested whether acquisition of resistance to deadhesion-induced apoptosis (anoikis in human osteosarcoma would result in resistance to chemotherapy. Methods Osteosarcoma cell lines (SAOS-2 and TE-85 obtained from ATCC and were maintained in complete Eagle's MEM medium. Suspension culture was established by placing cells in tissue culture wells coated with poly-HEMA. Cell cytotoxicity was determined using a live/dead cytotoxicity assay. Cell cycle/apoptosis analyses were performed using propidium iodide (PI staining with subsequent FACS analysis. Apoptosis was also assayed by Annexin-FITC/PI staining. Results Etoposide, adriamycin, vinblastine, cisplatin and paclitaxel were able to induce apoptosis in human osteosarcoma cells SAOS-2 regardless of their anoikis resistance phenotype or the culture conditions (adhered vs. suspended. Moreover, suspended anoikis resistant TE-85 cells (TE-85ar retained their sensitivity to chemotherapy as well. Conclusion Acquisition of anoikis resistance in human osteosarcoma cells does not result in a generalized resistance to all apoptotic stimuli, including chemotherapy. Moreover, our results suggest that the pathways regulating anoikis resistance and chemotherapy resistance might involve the action of different mediators.

Relation between aerosol sources and meteorological parameters for inhalable atmospheric particles in Sao Paulo City, Brazil

Science.gov (United States)

Andrade, Fatima; Orsini, Celso; Maenhaut, Willy

Stacked filter units were used to collect atmospheric particles in separate coarse and fine fractions at the Sao Paulo University Campus during the winter of 1989. The samples were analysed by particle-induced X-ray emission (PIXE) and the data were subjected to an absolute principal component analysis (APCA). Five sources were identified for the fine particles: industrial emissions, which accounted for 13% of the fine mass; emissions from residual oil and diesel, explaining 41%; resuspended soil dust, with 28%; and emissions of Cu and of Mg, together with 18%. For the coarse particles, four sources were identified: soil dust, accounting for 59% of the coarse mass; industrial emissions, with 19%; oil burning, with 8%; and sea salt aerosol, with 14% of the coarse mass. A data set with various meteorological parameters was also subjected to APCA, and a correlation analysis was performed between the meteorological "absolute principal component scores" (APCS) and the APCS from the fine and coarse particle data sets. The soil dust sources for the fine and coarse aerosol were highly correlated with each other and were anticorrelated with the sea breeze component. The industrial components in the fine and coarse size fractions were also highly positively correlated. Furthermore, the industrial component was related with the northeasterly wind direction and, to a lesser extent, with the sea breeze component.

Bench-to-bedside review: human subjects research--are more standards needed?

Science.gov (United States)

Huang, David T; Hadian, Mehrnaz

2006-01-01

There are many controversial issues surrounding ethics in study design and conduct of human subjects research. In this review we briefly touch on the origin of ethics in clinical research and how the current regulations and standards came into practice. We then discuss current controversies regarding informed consent, conflicts of interest, institutional review boards, and other relevant issues such as innovative procedures and quality improvement projects. The question of whether we need more standards is a very important yet challenging one to which there is no simple answer. We address this question by reviewing and commenting on relevant literature. We conclude that what is needed are not more standards per se, but rather refinement and uniformity of current standards, and their interpretation and application both to protect human subjects and to advance medicine.

Indoor Particulate Matter in Houses of Elderly in the Metropolitan Area of Sao Paulo, Brazil

Science.gov (United States)

Segalin, B.; Goncalves, F. T.; Fornaro, A.

2015-12-01

Environmental Company of the State of Sao Paulo (CETESB), Brazil, is responsible for particulate matter measurements (PM) in the Metropolitan Area of Sao Paulo (MASP). However, there are few works with indoor measures for MASP. Therefore, the aim of this work is to investigate the PM in households in the MASP. The chosen households were there are aged people over 60 years old. The measurements were sampled during 24 hours using a Personal Cascade Impactor (SKC Cat No. 225-370), which the following aerodynamic diameters: 10.0 - 2.5 (A); 1.0 - 2.5 (B); 0.50 - 1.0 (C); 0.25 - 0.50 (D), and < 0.25 μm (E). Together the impactor, there is a Leland Legacy pump (SKC Cat No. 100-3002) with a flow of 9L/min. It was analyzed 56 households with average values of PM10 and PM2.5 of 30.7 and 23.4 μg/m3, respectively. On average, 76% of PM10 consists of PM2.5, percentage higher than the outdoor environment (60% - CETESB), and 43% of the PM2.5 consists of PM smaller than 0.25 μm. Among all households, there was no exceedance of thresholds national standards PM10 (120 μg/m3) and PM2.5 (60 μg/m3). However, 10.7% of residences exceeded the PM10 threshold of the World Health Organization (50 μg/m3) and 39.2% for PM2.5 (20 μg/m3). The cluster analysis grouped the measures in the houses in four profiles. In three of them were greater amount of mass in ultrafine particles (E), followed by coarse particles (A) with the minimum in C level. The maximum in E may be due to the high contribution vehicular and secondary aerosol outdoor environment. The secondary maximum in A may be due to particles ressuspension and also arising from outdoors. These three groups differ only by the amount of PM measured in the households; they represent high, medium and low PM concentrations. The fourth group has average concentrations, but it presents a different profile because its maximum is in the D rather than E. All data will be analyzed concerning the possible sources.

GLP-1 and Calcitonin Concentration in Humans: Lack of Evidence of Calcitonin Release from Sequential Screening in over 5000 Subjects with Type 2 Diabetes or Nondiabetic Obese Subjects Treated with the Human GLP-1 Analog, Liraglutide

DEFF Research Database (Denmark)

Hegedüs, Laszlo; Moses, Alan C; Zdravkovic, Milan

2011-01-01

to the GLP-1 receptor agonist liraglutide in subjects with type 2 diabetes mellitus or nondiabetic obese subjects. Methods: Unstimulated serum CT concentrations were measured at 3-month intervals for no more than 2 yr in a series of trials in over 5000 subjects receiving liraglutide or control therapy....... Results: Basal mean CT concentrations were at the low end of normal range in all treatment groups and remained low throughout the trials. At 2 yr, estimated geometric mean values were no greater than 1.0 ng/liter, well below upper normal ranges for males and females. Proportions of subjects whose CT...

High prevalence of hepatitis E virus antibodies in Sao Paulo, Southeastern Brazil: analysis of a group of blood donors representative of the general population.

Science.gov (United States)

Passos-Castilho, Ana Maria; Reinaldo, Mônica Renata; Sena, Anne de; Granato, Celso F H

Brazil is a non-endemic country for hepatitis E virus (HEV) infection with seroprevalence from 1% to 4% in blood donors and the general population. However, data on seroprevalence of HEV in the country are still limited. This study evaluated the prevalence of past or present HEV infection in a group of blood donors representative of the general population of the city of Sao Paulo, Southeastern Brazil. Serum samples from 500 blood donors were tested from July to September 2014 by serological and molecular methods. Anti-HEV IgG antibodies were detected in 49 (9.8%) subjects and categorized age groups revealed an age-dependent increase of HEV seroprevalence. Among the anti-HEV IgG positive subjects, only 1 had anti-HEV IgM while none tested positive for HEV-RNA. The present data demonstrate a higher seroprevalence of anti-HEV IgG than previously reported in the region. Copyright © 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

Ethical issues in neonatal research involving human subjects.

Science.gov (United States)

Fleischman, Alan R

2016-06-01

Research involving critically ill neonates creates many ethical challenges. Neonatal clinical research has always been hard to perform, is very expensive, and may generate some unique ethical concerns. This article describes some examples of historical and modern controversies in neonatal research, discusses the justification for research involving such vulnerable and fragile patients, clarifies current federal regulations that govern research involving neonates, and suggests ways that clinical investigators can develop and implement ethically grounded human subjects research. Copyright © 2016 Elsevier Inc. All rights reserved.

Changes in markers of oxidative stress and DNA damage in human visceral adipose tissue from subjects with obesity and type 2 diabetes.

Science.gov (United States)

Jones, D A; Prior, S L; Barry, J D; Caplin, S; Baxter, J N; Stephens, J W

2014-12-01

In the past 30 years, prevalence of obesity has almost trebled resulting in an increased incidence of type 2 diabetes mellitus and other co-morbidities. Visceral adipose tissue is believed to play a vital role, but underlying mechanisms remain unclear. Our aim was to investigate changes in markers of oxidative damage in human visceral adipose tissue to determine levels of oxidative burden that may be attributed to obesity and/or diabetes. Visceral adipose tissue samples from 61 subjects undergoing abdominal surgery grouped as lean, obese and obese with type 2 diabetes mellitus, were examined using 3 different markers of oxidative stress. Malondialdehyde (MDA) concentration was measured as a marker of lipid peroxidation, telomere length and Comet assay as markers of oxidative DNA damage. No significant difference in MDA concentration, telomere length and DNA damage was observed between groups, although longer telomere lengths were seen in the obese with diabetes group compared to the obese group (Pstress and DNA damage was observed in samples from subjects with type 2 diabetes mellitus. Further work is required to investigate this further, however this phenomenon may be due to an up regulation of antioxidant defences in adipose tissue. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Hans Jonas' thought on the ethics of research on human subjects

African Journals Online (AJOL)

Dr Olaleye

use animals for research and experimentations to research on human subjects. Jonas upholds the ..... examples of ethical theory, the less said about it the better. But what is allowable .... Also, man seeks self-gratification and self- promotion.

Population of 224 realistic human subject-based computational breast phantoms

Energy Technology Data Exchange (ETDEWEB)

Erickson, David W. [Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Wells, Jered R., E-mail: jered.wells@duke.edu [Clinical Imaging Physics Group and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Sturgeon, Gregory M. [Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 (United States); Samei, Ehsan [Department of Radiology and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Departments of Physics, Electrical and Computer Engineering, and Biomedical Engineering, and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Dobbins, James T. [Department of Radiology and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Departments of Physics and Biomedical Engineering and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Segars, W. Paul [Department of Radiology and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States); Lo, Joseph Y. [Department of Radiology and Carl E. Ravin Advanced Imaging Laboratories, Duke University Medical Center, Durham, North Carolina 27705 and Departments of Electrical and Computer Engineering and Biomedical Engineering and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27705 (United States)

2016-01-15

Purpose: To create a database of highly realistic and anatomically variable 3D virtual breast phantoms based on dedicated breast computed tomography (bCT) data. Methods: A tissue classification and segmentation algorithm was used to create realistic and detailed 3D computational breast phantoms based on 230 + dedicated bCT datasets from normal human subjects. The breast volume was identified using a coarse three-class fuzzy C-means segmentation algorithm which accounted for and removed motion blur at the breast periphery. Noise in the bCT data was reduced through application of a postreconstruction 3D bilateral filter. A 3D adipose nonuniformity (bias field) correction was then applied followed by glandular segmentation using a 3D bias-corrected fuzzy C-means algorithm. Multiple tissue classes were defined including skin, adipose, and several fractional glandular densities. Following segmentation, a skin mask was produced which preserved the interdigitated skin, adipose, and glandular boundaries of the skin interior. Finally, surface modeling was used to produce digital phantoms with methods complementary to the XCAT suite of digital human phantoms. Results: After rejecting some datasets due to artifacts, 224 virtual breast phantoms were created which emulate the complex breast parenchyma of actual human subjects. The volume breast density (with skin) ranged from 5.5% to 66.3% with a mean value of 25.3% ± 13.2%. Breast volumes ranged from 25.0 to 2099.6 ml with a mean value of 716.3 ± 386.5 ml. Three breast phantoms were selected for imaging with digital compression (using finite element modeling) and simple ray-tracing, and the results show promise in their potential to produce realistic simulated mammograms. Conclusions: This work provides a new population of 224 breast phantoms based on in vivo bCT data for imaging research. Compared to previous studies based on only a few prototype cases, this dataset provides a rich source of new cases spanning a wide range

Conception of the Instrument Calibration Laboratory of Ionizing Radiation Measurement (LACIMRI) of CTMSP - Sao Paulo, SP

International Nuclear Information System (INIS)

Silva, Raimundo Dias da; Kibrit, Eduardo

2009-01-01

The present work describes the phases of implantation of calibration laboratory of ionizing radiation measurement instruments at the CTMSP, Sao Paulo, in a priory approved by CNEN, Brazil. That laboratory will allow and enhance the present metrological capacity for the attendance to the growing demand for calibration services of the instruments

Predictive modeling of human perception subjectivity: feasibility study of mammographic lesion similarity

Science.gov (United States)

Xu, Songhua; Hudson, Kathleen; Bradley, Yong; Daley, Brian J.; Frederick-Dyer, Katherine; Tourassi, Georgia

2012-02-01

The majority of clinical content-based image retrieval (CBIR) studies disregard human perception subjectivity, aiming to duplicate the consensus expert assessment of the visual similarity on example cases. The purpose of our study is twofold: i) discern better the extent of human perception subjectivity when assessing the visual similarity of two images with similar semantic content, and (ii) explore the feasibility of personalized predictive modeling of visual similarity. We conducted a human observer study in which five observers of various expertise were shown ninety-nine triplets of mammographic masses with similar BI-RADS descriptors and were asked to select the two masses with the highest visual relevance. Pairwise agreement ranged between poor and fair among the five observers, as assessed by the kappa statistic. The observers' self-consistency rate was remarkably low, based on repeated questions where either the orientation or the presentation order of a mass was changed. Various machine learning algorithms were explored to determine whether they can predict each observer's personalized selection using textural features. Many algorithms performed with accuracy that exceeded each observer's self-consistency rate, as determined using a cross-validation scheme. This accuracy was statistically significantly higher than would be expected by chance alone (two-tailed p-value ranged between 0.001 and 0.01 for all five personalized models). The study confirmed that human perception subjectivity should be taken into account when developing CBIR-based medical applications.

Analysis of Human Communication during Assembly Tasks.

Science.gov (United States)

1986-06-01

AD-A7l 43 ANALYSIS OF HUMAN COMMUNICATION DURING ASSEMBLY TASKS in1(U) CRNEGIE-MELLO UNIY PITTSBURGH PA ROBOTICS INST UNCLSSIIEDK S BARBER ET AL...ao I Dur~~~~IngAbcbyTs; 7c .S:in i lSAo .0. Analysis of Human Communication During Assembly Tasks K. Suzanne Barber and Gerald J. Agin CMU-RI-TR-86-1...TYPE or REPORT & PE-Rioo CevCZaz Analysis of Human Communication During Assembly Inlterim Tasks I . PERFORMING 00RG. REPORT NUMBER 1. £UT~oOR~e) IL

Culturally Relevant Human Subjects Protection Training: A Case Study in Community-Engaged Research in the United States.

Science.gov (United States)

Kue, Jennifer; Szalacha, Laura A; Happ, Mary Beth; Crisp, Abigail L; Menon, Usha

2018-02-01

Non-academic members of research teams, such as community members, can perceive traditional human subjects protection training as lacking in cultural relevance. We present a case exemplar of the development of a human subjects protection training for research staff with limited English proficiency and/or no or limited research experience. Seven modules were adapted for language, cultural examples, etc., from the standard Collaborative Institutional Training Initiative (CITI) human subjects protection training. Non-academic research staff completed a day-long training in human subjects protection (six modules) and our research protocol (one module). We assessed comprehension of content with PowerPoint slides and module quizzes. All participants successfully passed each module quiz with ≥ 80% correct. Questions answered incorrectly were discussed before proceeding to the next module. To meet the increasing demand for collaborative community-engaged research with underserved minority populations, human subjects protection training protocols can be adapted successfully to reflect real-world situations and provide culturally relevant materials to help non-academic research staff better understand the importance and necessity of research ethics.

Physiological and subjective evaluation of a human-robot object hand-over task.

Science.gov (United States)

Dehais, Frédéric; Sisbot, Emrah Akin; Alami, Rachid; Causse, Mickaël

2011-11-01

In the context of task sharing between a robot companion and its human partners, the notions of safe and compliant hardware are not enough. It is necessary to guarantee ergonomic robot motions. Therefore, we have developed Human Aware Manipulation Planner (Sisbot et al., 2010), a motion planner specifically designed for human-robot object transfer by explicitly taking into account the legibility, the safety and the physical comfort of robot motions. The main objective of this research was to define precise subjective metrics to assess our planner when a human interacts with a robot in an object hand-over task. A second objective was to obtain quantitative data to evaluate the effect of this interaction. Given the short duration, the "relative ease" of the object hand-over task and its qualitative component, classical behavioral measures based on accuracy or reaction time were unsuitable to compare our gestures. In this perspective, we selected three measurements based on the galvanic skin conductance response, the deltoid muscle activity and the ocular activity. To test our assumptions and validate our planner, an experimental set-up involving Jido, a mobile manipulator robot, and a seated human was proposed. For the purpose of the experiment, we have defined three motions that combine different levels of legibility, safety and physical comfort values. After each robot gesture the participants were asked to rate them on a three dimensional subjective scale. It has appeared that the subjective data were in favor of our reference motion. Eventually the three motions elicited different physiological and ocular responses that could be used to partially discriminate them. Copyright © 2011 Elsevier Ltd and the Ergonomics Society. All rights reserved.

Bioavailability and Pharmacodynamics of Promethazine in Human Subjects

Science.gov (United States)

Boyd, J. L.; Boster, B.; Wang, Z.; Shah, V.; Berens, K. L.; Sipes, W. E.; Anderson, K. E.; Putcha, L.

2004-01-01

The acute effects of exposure to microgravity include the development of space motion sickness, which usually requires therapeutic intervention. The current drug of choice, promethazine (PMZ), is available to astronauts in three different dosage forms during space flight; its side effects include nausea, dizziness, sedation and impaired psychomotor performance. This ground-based study is designed to validate flight-suitable methods for pharmacodynamic evaluation of PMZ and to estimate bioavailability and pharmacodynamics of PMZ. Experimental design consists of intramuscular administration of three doses of PMZ (12.5,25 and 50 mg) and placebo in a randomized double blind fashion to human subjects and collecting blood, urine and saliva samples for 72 h. Subjects also complete cognitive performance test batteries, WinSCAT (Windows based Space Cognitive Assessment Test) and ARES (ANAM Readiness Evaluation System). Preliminary results indicate a significant relationship (p=9.88e-05) between circulating PMZ levels and cognitive performance parameters. Time to accurately complete memory tasks increases significantly with concentrations; higher concentrations also increase response time and decrease accuracy of substitution and matching tasks. AUC and half-life estimates for PMZ ranged between 0.12 and 1.7 mg.h/L and 15 and 50 h, respectively. These preliminary results indicate that PMZ may exhibit dose-dependent pharmacokinetics in humans; also, WinSCAT and ARES are sensitive for pharmacodynamic assessment of PMZ, and may be applicable for assessing the pharmacodynamics of other neurocognitive drugs.

Specifics of Educational Texts Selection for Schoolchildren Doing the Humanities Subjects

Directory of Open Access Journals (Sweden)

T. V. Oblasova

2012-01-01

Full Text Available The paper proposes the new approach to educational text selection for the humanities teaching. Its specifics is based on the wide interpretation of educational texts, as the culture texts involved in cognitive learning activity and fulfilling the multiple tasks of the related subjects and personal development. The educational text is taken as a generalized model, its content and structure determining the scheme of a speech cognitive activity, as well as the meaning formation mechanism responsible for understanding and personal development. The texts and tasks selection is oriented on schoolchildren’s understanding with the reference to the psycholinguistic, psychological and hermeneutic approaches; information extraction and interpretation level related to the author’s and student’s context. The given approach could provide the basis for developing and structuring the textbooks content for the humanities subjects. 

Wheat bran cereal, human gut bacteria and subjective wellbeing

OpenAIRE

Smith, Andrew; Deaville, Eddie; Gibson, Glenn

2018-01-01

Research has shown that consumption of high fiber breakfast cereal is associated with improved subjective well-being, especially increased energy. One possible explanation of these results is through metabolism by gut bacteria and concomitant production of metabolites that influence psychological and gastrointestinal (GI) welfare. This was examined in the present study to determine whether consumption of wheat bran could modulate the composition of the GI microbiota. This human volunteer stud...

Conservation programs impact in the industrial energetic demand of the Sao Paulo State

International Nuclear Information System (INIS)

Silva Walter, A.C. da; Bajay, S.V.

1987-01-01

This paper describes the evaluation methodology of the impacts of conservation and substitution programs on the industrial energy demand in the State of Sao Paulo. The main industrial sectors are investigated. An econometric energy demand forecasting model is used to project the demand in the planning period. After an analysis of the conservation and substitution possibilities in each industrial sector, a correction in the projected demand is made through adoption of assumptions oriented by these studies. (author)

Liver afferents contribute to water drinking-induced sympathetic activation in human subjects: a clinical trial.

Directory of Open Access Journals (Sweden)

Marcus May

Full Text Available Water drinking acutely increases sympathetic activity in human subjects. In animals, the response appears to be mediated through transient receptor potential channel TRPV4 activation on osmosensitive hepatic spinal afferents, described as osmopressor response. We hypothesized that hepatic denervation attenuates water drinking-induced sympathetic activation. We studied 20 liver transplant recipients (44±2.6 years, 1.2±0.1 years post transplant as model of hepatic denervation and 20 kidney transplant recipients (43±2.6 years, 0.8±0.1 years post transplant as immunosuppressive drug matched control group. Before and after 500 ml water ingestion, we obtained venous blood samples for catecholamine analysis. We also monitored brachial and finger blood pressure, ECG, and thoracic bioimpedance. Plasma norepinephrine concentration had changed by 0.01±0.07 nmol/l in liver and by 0.21±0.07 nmol/l in kidney transplant recipients (p<0.05 between groups after 30-40 minutes of water drinking. While blood pressure and systemic vascular resistance increased in both groups, the responses tended to be attenuated in liver transplant recipients. Our findings support the idea that osmosensitive hepatic afferents are involved in water drinking-induced sympathetic activation in human subjects.ClinicalTrials.gov NCT01237431.

Liver Afferents Contribute to Water Drinking-Induced Sympathetic Activation in Human Subjects: A Clinical Trial

Science.gov (United States)

May, Marcus; Gueler, Faikah; Barg-Hock, Hannelore; Heiringhoff, Karl-Heinz; Engeli, Stefan; Heusser, Karsten; Diedrich, André; Brandt, André; Strassburg, Christian P.; Tank, Jens; Sweep, Fred C. G. J.; Jordan, Jens

2011-01-01

Water drinking acutely increases sympathetic activity in human subjects. In animals, the response appears to be mediated through transient receptor potential channel TRPV4 activation on osmosensitive hepatic spinal afferents, described as osmopressor response. We hypothesized that hepatic denervation attenuates water drinking-induced sympathetic activation. We studied 20 liver transplant recipients (44±2.6 years, 1.2±0.1 years post transplant) as model of hepatic denervation and 20 kidney transplant recipients (43±2.6 years, 0.8±0.1 years post transplant) as immunosuppressive drug matched control group. Before and after 500 ml water ingestion, we obtained venous blood samples for catecholamine analysis. We also monitored brachial and finger blood pressure, ECG, and thoracic bioimpedance. Plasma norepinephrine concentration had changed by 0.01±0.07 nmol/l in liver and by 0.21±0.07 nmol/l in kidney transplant recipients (pwater drinking. While blood pressure and systemic vascular resistance increased in both groups, the responses tended to be attenuated in liver transplant recipients. Our findings support the idea that osmosensitive hepatic afferents are involved in water drinking-induced sympathetic activation in human subjects. Trial Registration ClinicalTrials.gov NCT01237431 PMID:22016786

Engaging Institutional Review Boards in Developing a Brief, Community-Responsive Human Subjects Training for Community Partners

Science.gov (United States)

Calzo, Jerel P.; Bogart, Laura M.; Francis, Evelyn; Kornetsky, Susan Z.; Winkler, Sabune J.; Kaberry, Julie M.

2017-01-01

BACKGROUND Engaging community partners as co-investigators in community-based participatory research (CBPR) requires certification in the rules, ethics, and principles governing research. Despite developments in making human research protection trainings more convenient and standardized (e.g., self-paced Internet modules), time constraints and the structure of the content (which may favor academic audiences) may hinder the training of community partners. OBJECTIVES This paper is motivated by a case example in which academic and community partners, and stakeholders of a community-based organization actively engaged the leadership of a pediatric hospital-based Institutional Review Board (IRB) in implementing a brief, community-responsive human subjects training session. METHODS A two hour, discussion-based human subjects training was developed via collaborations between the IRB and the community and academic partners. Interviews with trainees and facilitators after the training were used to evaluate its acceptability and possible future applications. CONCLUSIONS Local Institutional Review Boards have the potential to assist community partners in building sufficient knowledge of human subjects research protections to engage in specific projects, thereby expediting the progress of vital research to address community needs. We propose the need for developing truncated human subjects education materials to train and certify community partners, and creating formally organized entities within academic and medical institutions that specialize in community-based research to guide the development and implementation of alternative human subjects training certification opportunities for community partners. PMID:28230554

Hydrochemical and isotopic study of the Botucatu aquifer ground waters in Sao Paulo State

International Nuclear Information System (INIS)

Silva, R.B.G. da.

1983-01-01

The process controlling chemical composition of ground water,its origin and apparent age as well as, the natural flow rate of the water in Botucatu aquifer in state of Sao Paulo, Brazil, have been investigated using hydrochemical and environmental isotopic ( 18 O, 2 H, 13 C, 14 C) Technics. The main recharge process is assumed to be the infiltration of rain water in the aquifer outcrop area. The progressive confining conditions with the increasing depth of the top of the aquifer layer makes the ground water temperature slowly greater. The recent magnesium and sodium bicarbonated waters changes first to sodium bicarbonated and then to sodium chloride-sulfated waters which are oldest found out in the research area(around 30.000 years ago). The mean Darcy permeability estimated on basis of 14 C and hydraulic gradient data is 2.6x10 -5 m/s. 9 maps (author) [pt

Seasonal variations of 222Rn and SGD fluxes to Ubatuba embayments, Sao Paulo

International Nuclear Information System (INIS)

Oliveira, J.; Costa, P.; Braga, E.S.

2006-01-01

We describe here an application of excess 222 Rn to estimate submarine groundwater discharge in a series of small embayments of Ubatuba, Sao Paulo State, Brazil. Excess 222 Rn inventories obtained in 11 vertical profiles varied from (3.3±1.1) x 10 3 to (19±5) x 10 3 dpm x m -2 . The estimated total fluxes required to support the inventories varied from (0.6±0.2) x 10 3 to (3.4±0.9) x 10 3 dpm x m -2 x d -1 . Considering these results, the submarine groundwater discharge advective rates necessary to balance the sub-pycnocline fluxes calculated in Ubatuba embayments ranged from 0.06 to 1.9 cm x d -1 . During the period of this investigation (from March/03 to May/2004), the highest 222 Rn in excess inventories were observed late in the summer season (March). Taking into account all vertical profiles established, the relative variability was 67%. Although, if we consider only the fluxes determined in both Flamengo and Fortaleza embayments, the relative variation was 21%. (author)

Modal analysis of human body vibration model for Indian subjects under sitting posture.

Science.gov (United States)

Singh, Ishbir; Nigam, S P; Saran, V H

2015-01-01

Need and importance of modelling in human body vibration research studies are well established. The study of biodynamic responses of human beings can be classified into experimental and analytical methods. In the past few decades, plenty of mathematical models have been developed based on the diverse field measurements to describe the biodynamic responses of human beings. In this paper, a complete study on lumped parameter model derived from 50th percentile anthropometric data for a seated 54- kg Indian male subject without backrest support under free un-damped conditions has been carried out considering human body segments to be of ellipsoidal shape. Conventional lumped parameter modelling considers the human body as several rigid masses interconnected by springs and dampers. In this study, concept of mass of interconnecting springs has been incorporated and eigenvalues thus obtained are found to be closer to the values reported in the literature. Results obtained clearly establish decoupling of vertical and fore-and-aft oscillations. The mathematical modelling of human body vibration studies help in validating the experimental investigations for ride comfort of a sitting subject. This study clearly establishes the decoupling of vertical and fore-and-aft vibrations and helps in better understanding of possible human response to single and multi-axial excitations.

Total Diet Study. Mg and Mn content estimation of a Market Basket of Sao Paulo state (Brazil) by Instrumental Neutron Activation

International Nuclear Information System (INIS)

Roseane Pagliaro Avegliano; Vera Akiko Maihara

2014-01-01

Total Diet Studies (TDS) have been carried out to estimate dietary intakes of the essential and toxic elements for a large-scale population over a specific period of time. In this study, the TDS was based on the evaluation of food representing a Market Basket (MB), which reflected the dietary habits of the Sao Paulo State population, corresponding to 72 % of the average food consumption for the state of Sao Paulo. In the present Total Diet Study, magnesium and manganese concentrations were determined in 30 of the most consumed food groups of a MB of Sao Paulo State, Brazil. Instrumental Neutron Activation Analysis (INAA) has been successfully used on a regularly basis in several areas of nutrition and foodstuffs. Element concentrations were determined by INAA in freeze-dried samples and ranged in mg kg -1 . Mg 41.4 (fats)-5287 (coffee) and Mn 0.12 (prime grade beef)-32.9 (coffee). The average daily Mg and Mn intake was calculated by multiplying the concentration of each element in each table-ready food group by the respective weight (g day -1 ) of the food group in the MB and adding the products from all food groups. The results of daily dietary intakes in this study were: Mg 174.8 and Mn 1.34 mg day -1 . Theses values were lower than the adequate intake (AI) proposed by the Food and Nutrition Board of the Institute of Medicine (USA National Academy) for adults. The low levels of Mg and Mn intakes presented in this TDS are probably due to the fact that MB of this study represented only 72 % of the weight of the most consumed household foods of Sao Paulo State. (author)

Methodology for correlations between doses and detectability in standard mammographic images: application in Sao Paulo state

International Nuclear Information System (INIS)

Furquim, Tania Aparecida Correia

2005-01-01

Measurements using mammography units were performed in loco in 50 health establishments, randomly sampled from an equipment list of the Cadastro Nacional de Estabelecimentos de Saude (Health Establishments Brazilian Catalog). For the measurements six phantoms were utilized to establish different quality criteria and to evaluate doses in different breast thicknesses. Two different methods of measuring average glandular doses (AGD) were applied, and measurements of entrance surface doses (ESD) were also realized, in order to obtain mean values to Sao Paulo State. A study relating distribution and properties of different mammography trademarks with doses was performed. The sensitometry of processors allowed a quantification of the film-processing contrast index, A g , establishing a state mean value. The phantom images allowed the evaluation of detection limits of structures as microcalcifications, fibers, and masses, and state mean values were established for: spatial resolution (on surface and glandular breast position); image contrast; and detection expert ability from phantom images in two situations: before knowing the image targets and after viewing of a target map. Then, the results were compared to target detections in laboratory environment. Based on dose results, A g , image contrast, maximum contrast, and detection ratio, a relationship between them was determined. The results show that, in Sao Paulo State, mean glandular doses were lower than reference levels considering the Wu method, and close to or above reference levels for ail phantoms considering the Dance method. The ESD was always close to or above reference levels. The A g presented a mean value of (10,42 ± 0,20) for Sao Paulo State, and the image contrast was lower than the required limits established by the phantom manufacturers. The high contrast resolution showed that mammography units presented the expected values of line pair per mm in the State. The detectability evaluation of local

Deuterium labelling of the antidepressant drug doxepin for disposition studies in human subjects

International Nuclear Information System (INIS)

Prakash, Chandra; Saleh, Samir; Wilkinson, G.R.; Blair, I.A.; Taber, D.F.

1990-01-01

Two methods have been developed for the introduction of deuterium into the doxepin molecule. The key intermediate (6,11-dihydro-1,2,3,4- 2 H 4 -dibenz[b,e]oxepin-11-one) was prepared by condensation of ethyl 2-bromomethylbenzoate with [ 2 H 6 ]-phenol, saponification of the resulting ester, and dehydration with trifluoroacetic anhydride. Using this key intermediate, E-(1,2,3,4)- 2 H 4 -doxepin was prepared for administration to human subjects. (1,2,3,4)- 2 H 4 -N-desmethyldoxepin, (1,2,3,4,1',2',2')- 2 H 7 -doxepin, (1,2,3,4)- 2 H 4 -(H 2 H 3 ) 2 -doxepin ( 2 H 10 -doxepin) and (1,2,3,4,1',2',2')- 2 H 7 -N-desmethyldoxepin were also prepared for use as internal standards in GC/MS assays. The deuterated compounds contained less than 0.5% protium impurity. (author)

Deuterium and oxygen-18 concentrations in rain and river waters from Minas Gerais, Sao Paulo and Parana States, Brazil

International Nuclear Information System (INIS)

Vieira, Oliveiro J.; Salati, Eneas

1982-01-01

The main object of this paper was to study the concentration of deuterium (D) and Oxygen-18 ( 18 O) in the rain and river waters from the States of Minas Gerais, Sao paulo and Parana. Monthly samples were prepared and analysed at the Centro de Energia Nuclear na Agricultura (CENA-ESALQ-USP) with the use of CH-4 ( 18 O) and GD-150 (D) mass spectrometers of Varian-Mat. In order to correlate the D and 18 O of the rain water the equation δD = 9.22 + 7.17δ18 was found. Considering the three equations separately it was observed that the parameter a = δD -bδ18 increases from the South to the North. For the Piracicaba River (city of Piracicaba only), the D and 18 O relationship was expressed by δD = -10.98 + 4.88δ18. The States of Minas Gerais and Sao Paulo can be divided according to the weight-average concentrations (δ18 m% 0 ). This division is not possible from Parana. Considering the average from the weight average concentration (annually and summer) for the three States, the annual average (D and 18 O) is slightly richer than the summer average, showing the importance of the amount effect, mainly for the States of Minas Gerais and Sao Paulo. The rivers studied had little variation in the 18 O concentrations with no definite periodicity. The rivers from the North of Minas Gerais are slightly richer in 18 O than the rivers from the South. The waters from Rio Grande in the South of Minas Gerais State are poorer in 18 O than the water of the same river in the 'Triangle'region. The δ18% 0 data for the rivers Grande, Parnaiba and Parana are very similar, so there is no way to compute the contribution of the first and the second rivers in the formation of the third. (author). 20 refs., 2 figs., 8 tabs

The Public Health Service guidelines. Governing research involving human subjects: An analysis of the policy-making process

Science.gov (United States)

Frankel, M. S.

1972-01-01

The policy making process which led to development of the Public Health Service Guidelines governing research involving human subjects is outlined. Part 1 examines the evolution of PHS Guidelines, tracing (1) evolution of thought and legal interpretation regarding research using human subjects; (2) initial involvement of the Federal government; (3) development of the government's research program; (4) the social-political environment in which formal government policy was developed; and (5) various policy statements issued by the government. Part 2 analyzes the process by which PHS Guidelines were developed and examines the values and other underlying factors which contributed to their development. It was concluded that the evolution of the Guidelines is best understood within the context of a mixed-scanning strategy. In such a strategy, policy makers make fundamental decisions regarding the basic direction of policy and subsequent decisions are made incrementally and within the contexts set by the original fundamental decisions.

Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects.

Directory of Open Access Journals (Sweden)

Dominik M Schulte

Full Text Available Obesity is associated with macrophage infiltration of adipose tissue. These inflammatory cells affect adipocytes not only by classical cytokines but also by the secreted glycopeptide wnt5a. Healthy adipocytes are able to release the wnt5a inhibitor sFRP5. This protective effect, however, was found to be diminished in obesity. The aim of the present study was to examine (1 whether obese human subjects exhibit increased serum concentrations of wnt5a and (2 whether wnt5a and/or sFRP5 serum concentrations in obese subjects can be influenced by caloric restriction.23 obese human subjects (BMI 44.1 ± 1.1 kg/m(2 and 12 age- and sex-matched lean controls (BMI 22.3 ± 0.4 kg/m(2 were included in the study. Obese subjects were treated with a very low-calorie diet (approximately 800 kcal/d for 12 weeks. Body composition was assessed by impedance analysis, insulin sensitivity was estimated by HOMA-IR and the leptin-to-adiponectin ratio and wnt5a and sFRP5 serum concentrations were measured by ELISA. sFRP5 expression in human adipose tissue biopsies was further determined on protein level by immunohistology.Pro-inflammatory wnt5a was not measurable in any serum sample of lean control subjects. In patients with obesity, however, wnt5a became significantly detectable consistent with low grade inflammation in such subjects. Caloric restriction resulted in a weight loss from 131.9 ± 4.0 to 112.3 ± 3.2 kg in the obese patients group. This was accompanied by a significant decrease of HOMA-IR and leptin-to-adiponectin ratio, indicating improved insulin sensitivity. Interestingly, these metabolic improvements were associated with a significant increase in serum concentrations of the anti-inflammatory factor and wnt5a-inhibitor sFRP5.Obesity is associated with elevated serum levels of pro-inflammatory wnt5a in humans. Furthermore, caloric restriction beneficially affects serum concentrations of anti-inflammatory sFRP5 in such subjects. These findings suggest a

Scenario of distributed energetic resources in the state of Sao Paulo, Brazil; O cenario dos recursos energeticos distribuidos no estado de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Burani, Geraldo Francisco; Udaeta, Miguel Edgar Morales; Fujii, Ricardo Junqueira; Galvao, Luiz Claudio Ribeiro [Universidade de Sao Paulo (USP), SP (Brazil). Dept. de Engenharia de Energia e Automacao Eletricas. Grupo de Energia], e-mail: udaeta@pea.usp.br

2004-07-01

This paper aims to assess the viability of the use of distributed resources for power production inside the state of Sao Paulo, taking into account its different forms, advantages and drawbacks. To accomplish the assessment and using de integrated energy resources planning, the full cost accounting for energy resources was applied to each administrative region of the state, which allowed a greater focus without jeopardizing the final results. The analysis were performed considering the usage of the most prospective energy sources such as wind, solar, natural gas, hydro and biomass generation; the results show that when the different aspects of each type of distributed generation are taken into account the renewable forms of energy generation are likely to be more competitive, when compared to traditional forms of generation. (author)

The AIR's policy on research involving the irradiation of human subjects

International Nuclear Information System (INIS)

Smith, A.N.

1995-01-01

The policy of the Australian Institute of Radiography with regards to the human subject irradiation is outlined. It is stated that members will not irradiate another individual, nor themselves, solely for the purposes of experimentation or research without gaining the prior approval of an institutional ethics committee. Where possible, researchers should consider the use of patient equivalent or human tissue equivalent phantoms. A short list of references has been compiled to assist members in designing research protocols which comply with the stated policy

Ethics in action: Approving and improving medical research with human subjects

NARCIS (Netherlands)

de Jong, J.P.

2013-01-01

In this thesis, Jean Philippe de Jong presents a new understanding of ethical oversight on medical research with human subjects and proposes that two philosophies for ethical oversight exist: '(dis)approving' and 'improving'. Systems for ethical oversight on medical research have been in place for

Incidence of Leptospirosis infection in the East Zone of Sao Paulo City, Brazil

Science.gov (United States)

2013-01-01

Background Leptospirosis is a zoonosis which is spread through contamined running water. This contaminations is seriously affected by the flooding which occurs in the area surrounding the Aricanduva river. The transmission of the disease results mainly from the contact of water with soil contaminated by the urine of infected animals. We aimed to conduct an epidemiological survey on Leptospirosis cases in Sao Paulo East Zone area. Method The analysis conducted in this study was based on data collected from the health authorities of that region close the Aricanduva river between 2007 and 2008 years, which give the rates of confirmed cases, mortality and death from human Leptospirosis. Other information concerned with the relationships among rainfall index, points of flooding and incidence of Leptospirosis. Results We observed a direct and important water contamination. Records of flooding points and dates of the reported cases in the region showed a direct relationship from which the period of higher rainfall also recorded an increase in cases. The annual record of the city and the region and rainfall regions also presented correlation. Conclusion The association between the indices of flooding and Leptospirosis cases indicates that preventive measures are necessary to avoid exposing the community. PMID:23672682

The bacterial meningitis score to distinguish bacterial from aseptic meningitis in children from Sao Paulo, Brazil.

Science.gov (United States)

Mekitarian Filho, Eduardo; Horita, Sérgio Massaru; Gilio, Alfredo Elias; Alves, Anna Cláudia Dominguez; Nigrovic, Lise E

2013-09-01

In a retrospective cohort of 494 children with meningitis in Sao Paulo, Brazil, the Bacterial Meningitis Score identified all the children with bacterial meningitis (sensitivity 100%, 95% confidence interval: 92-100% and negative predictive value 100%, 95% confidence interval: 98-100%). Addition of cerebrospinal fluid lactate to the score did not improve clinical prediction rule performance.

Mercury and selenium accumulation assessment in fish most consumed by Cubatao Community, Sao Paulo, Brazil

Energy Technology Data Exchange (ETDEWEB)

Farias, Luciana A.; Favaro, Deborah I.T.; Curcho, Michel R.S.M.; Fonseca, Barbara C.; Nascimento, Soraia M., E-mail: lufarias2@yahoo.com.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), SP (Brazil). Lab. de Analise por Ativacao de Neutrons; Kunioshi, Leonardo; Braga, Elisabete S., E-mail: edsbraga@usp.b [Universidade de Sao Paulo (USP), SP (Brazil). Inst. Oceanografico. Lab. de Nutrientes, Micronutrientes e Tracos nos Oceanos (LABNUT)

2009-07-01

High correlation between mercury (Hg) and selenium (Se) concentrations in fish organs is well known. In the present study, 58 fish samples of five fish species most commonly consumed by the Cubatao city population, Sao Paulo State, Brazil were analyzed. The Cubatao Estuary, located in southeastern Sao Paulo State, is an economically important area suffering severe environmental water quality problems due to industrial wastes, domestic sewage and solid residues. The waters of the bay suffer the impact of the immense industrial complex of Cubatao. In this study, Hg concentration in muscle, liver and kidney tissues and Se concentration in liver tissue from three predatory fish species: Macrodon ancylodon (Pescada), Menticirrhus americanus (Perna de Moca) and Micropogonias furnieri (Corvina) and two planctivorous species: Mugil liza (Tainha) and Sardella braziliensis (Sardinha) were determined. Mercury determination was performed using Cold Vapour Atomic Absorption Spectrometry (CV AAS) and selenium by Instrumental Neutron Activation Analysis (INAA). The muscle-Hg concentration variation (wet weight) was: (8 to 40 mug kg{sup -1}) - Sardinha; (12 to 62 mug kg{sup -1}) - Pescada; (3 to 23 mug kg{sup -1}) - Tainha; (43 to 184 mug kg{sup -1}) - Perna de Moca and (41 to 348 mug kg{sup -1}) - Corvina. The general concentration ranges of the analyzed elements in all species studied were (dry weight): muscle-Hg (13 to 1512 mug kg{sup -1}); liver-Hg (21 to 1804 mug kg{sup -1}); kidney-Hg 47 to 9912 mug kg{sup -1}) and liver-Se (2.10 to 43.00 mg kg{sup -1}). Se concentrations were higher than those of Hg in the liver. (author)

Mercury and selenium accumulation assessment in fish most consumed by Cubatao Community, Sao Paulo, Brazil

International Nuclear Information System (INIS)

Farias, Luciana A.; Favaro, Deborah I.T.; Curcho, Michel R.S.M.; Fonseca, Barbara C.; Nascimento, Soraia M.

2009-01-01

High correlation between mercury (Hg) and selenium (Se) concentrations in fish organs is well known. In the present study, 58 fish samples of five fish species most commonly consumed by the Cubatao city population, Sao Paulo State, Brazil were analyzed. The Cubatao Estuary, located in southeastern Sao Paulo State, is an economically important area suffering severe environmental water quality problems due to industrial wastes, domestic sewage and solid residues. The waters of the bay suffer the impact of the immense industrial complex of Cubatao. In this study, Hg concentration in muscle, liver and kidney tissues and Se concentration in liver tissue from three predatory fish species: Macrodon ancylodon (Pescada), Menticirrhus americanus (Perna de Moca) and Micropogonias furnieri (Corvina) and two planctivorous species: Mugil liza (Tainha) and Sardella braziliensis (Sardinha) were determined. Mercury determination was performed using Cold Vapour Atomic Absorption Spectrometry (CV AAS) and selenium by Instrumental Neutron Activation Analysis (INAA). The muscle-Hg concentration variation (wet weight) was: (8 to 40 μg kg -1 ) - Sardinha; (12 to 62 μg kg -1 ) - Pescada; (3 to 23 μg kg -1 ) - Tainha; (43 to 184 μg kg -1 ) - Perna de Moca and (41 to 348 μg kg -1 ) - Corvina. The general concentration ranges of the analyzed elements in all species studied were (dry weight): muscle-Hg (13 to 1512 μg kg -1 ); liver-Hg (21 to 1804 μg kg -1 ); kidney-Hg 47 to 9912 μg kg -1 ) and liver-Se (2.10 to 43.00 mg kg -1 ). Se concentrations were higher than those of Hg in the liver. (author)

Be-7 measured at ground air level and rainfall in the city of Sao Paulo

International Nuclear Information System (INIS)

Damatto, Sandra R.; Souza, Joseilton M.; Frujuele, Jonatan V.; Maduar, Marcelo F.; Leonardo, Lucio; Pecequilo, Brigitte R.S.

2013-01-01

The cosmogenic radionuclide 7 Be (T 1/2 = 53.3 d), produced in the upper atmosphere by cosmic ray spallation of oxygen and nitrogen, is one of the cosmogenic radionuclides that can be used as tracer for heavy metals and pollutants in the environment, tracer of soil erosion and sedimentation in lakes, among other examples. Their subsequent deposition to the land surface occurs as both wet and dry fallout, although it has been demonstrated that 7 Be fallout is primarily associated with precipitation. There is limited data on the concentration of 7 Be in rainfall and in particulate in the Southern Hemisphere and in Brazil, compared with data from the Northern Hemisphere. This paper presents the results obtained of 7 Be concentrations measured from April 2011 to June 2013, in samples of air at ground level, each fifteen days, and rainfall in all the rainy events that occurred at Instituto de Pesquisas Energeticas e Nucleares (IPEN), which has its campus located in the city of Sao Paulo, state of Sao Paulo, Brazil. The concentrations of 7 Be were measured by non-destructive gamma-ray spectrometry using an extended range closed-end coaxial Be-layer HPGe detector with 25% relative efficiency and associated electronic devices and live counting time varying from 100,000 s to 300,000 s. The results obtained of 7 Be in particulate and in rainfall were correlated to seasons, precipitation, temperature and sunspot number. The higher values obtained for the concentrations were in spring and summer time presenting good correlations with the amount of precipitation and sunspot number and a clear seasonal variation. (author)

Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain

Directory of Open Access Journals (Sweden)

Bouffard Nicole A

2009-12-01

Full Text Available Abstract Background Although the connective tissues forming the fascial planes of the back have been hypothesized to play a role in the pathogenesis of chronic low back pain (LBP, there have been no previous studies quantitatively evaluating connective tissue structure in this condition. The goal of this study was to perform an ultrasound-based comparison of perimuscular connective tissue structure in the lumbar region in a group of human subjects with chronic or recurrent LBP for more than 12 months, compared with a group of subjects without LBP. Methods In each of 107 human subjects (60 with LBP and 47 without LBP, parasagittal ultrasound images were acquired bilaterally centered on a point 2 cm lateral to the midpoint of the L2-3 interspinous ligament. The outcome measures based on these images were subcutaneous and perimuscular connective tissue thickness and echogenicity measured by ultrasound. Results There were no significant differences in age, sex, body mass index (BMI or activity levels between LBP and No-LBP groups. Perimuscular thickness and echogenicity were not correlated with age but were positively correlated with BMI. The LBP group had ~25% greater perimuscular thickness and echogenicity compared with the No-LBP group (ANCOVA adjusted for BMI, p Conclusion This is the first report of abnormal connective tissue structure in the lumbar region in a group of subjects with chronic or recurrent LBP. This finding was not attributable to differences in age, sex, BMI or activity level between groups. Possible causes include genetic factors, abnormal movement patterns and chronic inflammation.

Sustainable Campus Program: University of Sao Paulo and its contribution to the reduction of environmental and economic impacts; Programa Campus Sutentavel: a Universidade de Sao Paulo e sua contribuicao a reducao dos impactos ambientais e economicos

Energy Technology Data Exchange (ETDEWEB)

Vilela, M M; Grimoni, J A.B.; Burani, G F [Universidade de Sao Paulo (IEE/USP), SP (Brazil). Inst. de Eletrotecnica e Energia; Massola, A M.A.; Barbosa, E J.S.; Hamzo, S T; Guarnieri, M C; Prist, R; Sonnewend, J E.S. [Universidade de Sao Paulo (COSESP/USP), SP (Brazil). Coordenadoria do Campus da Capital

2010-07-01

This paper presents the actions and the results obtained by the action of the University of Sao Paulo (USP) in reduction of environmental impacts caused by its activities, the creation of standards and indicators to monitor the results, the training of personnel and development models of public administration that can be adopted by other universities and city, state and federal administration. (author)

How to do human-subjects research if you do not have an institutional review board.

Science.gov (United States)

Rice, Todd W

2008-10-01

Biomedical research with human subjects has expanded outside of traditional medical centers and hospitals into other health care entities, such as rehabilitation facilities, free-standing out-patient treatment centers, and even home-health agencies. Regardless of the location, federal regulations mandate that all human-subjects research must be overseen by an institutional review board (IRB) or ethics committee to ensure the research abide by the Code of Federal Regulations. Consequently, all human-subjects research must be reviewed and approved by an IRB prior to initiation of any research procedures. Unfortunately, many of these nontraditional research facilities do not have easy access to an IRB. This does not render such research exempt from federal oversight. Clinicians at these facilities have viable options for obtaining IRB approval and legally conducting such research. This paper outlines the available options and their pros and cons.

Salivary alpha amylase activity in human beings of different age groups subjected to psychological stress.

Science.gov (United States)

Sahu, Gopal K; Upadhyay, Seema; Panna, Shradha M

2014-10-01

Salivary alpha-amylase (sAA) has been proposed as a sensitive non-invasive biomarker for stress-induced changes in the body that reflect the activity of the sympathetic nervous system. Though several experiments have been conducted to determine the validity of this salivary component as a reliable stress marker in human subjects, the effect of stress induced changes on sAA level in different age groups is least studied. This article reports the activity of sAA in human subjects of different age groups subjected to psychological stress induced through stressful video clip. Differences in sAA level based on sex of different age groups under stress have also been studied. A total of 112 subjects consisting of both the male and female subjects, divided into two groups on basis of age were viewed a video clip of corneal transplant surgery as stressor. Activity of sAA from saliva samples of the stressed subjects were measured and compared with the activity of the samples collected from the subjects before viewing the clip. The age ranges of subjects were 18-25 and 40-60 years. The sAA level increased significantly in both the groups after viewing the stressful video. The increase was more pronounced in the younger subjects. The level of sAA was comparatively more in males than females in the respective groups. No significant change in sAA activity was observed after viewing the soothed video clip. Significant increase of sAA level in response to psychological stress suggests that it might act as a reliable sympathetic activity biochemical marker in different stages of human beings.

Bench-to-bedside review: Human subjects research – are more standards needed?

Science.gov (United States)

Huang, David T; Hadian, Mehrnaz

2006-01-01

There are many controversial issues surrounding ethics in study design and conduct of human subjects research. In this review we briefly touch on the origin of ethics in clinical research and how the current regulations and standards came into practice. We then discuss current controversies regarding informed consent, conflicts of interest, institutional review boards, and other relevant issues such as innovative procedures and quality improvement projects. The question of whether we need more standards is a very important yet challenging one to which there is no simple answer. We address this question by reviewing and commenting on relevant literature. We conclude that what is needed are not more standards per se, but rather refinement and uniformity of current standards, and their interpretation and application both to protect human subjects and to advance medicine. PMID:17184560

Long-term association between the intensity of cosmic rays and mortality rates in the city of Sao Paulo

Science.gov (United States)

Vieira, C. L. Z.; Janot-Pacheco, E.; Lage, C.; Pacini, A.; Koutrakis, P.; Cury, P. R.; Shaodan, H.; Pereira, L. A.; Saldiva, P. H. N.

2018-02-01

Human beings are constantly exposed to many kinds of environmental agents which affect their health and lifespan. Galactic cosmic rays (GCRs) are the main source of ionizing radiation in the lower troposphere, in which secondary products can penetrate the ground and underground layers. GCRs affect the physical-chemical properties of the terrestrial atmosphere, as well as the biosphere. GCRs are modulated by solar activity and latitudinal geomagnetic field distribution. In our ecological/populational retrospective study, we analyzed the correlation between the annual flux of local secondary GCR-induced ionization (CRII) and mortality rates in the city of Sao Paulo, Brazil, between 1951-2012. The multivariate linear regression analyses adjusted by demographic and weather parameters showed that CRII are significantly correlated with total mortality, infectious disease mortality, maternal mortality, and perinatal mortality rates (p < 0.001). The underlying mechanisms are still unclear. Further cross-sectional and experimental cohort studies are necessary to understand the biophysical mechanisms of the association found here.

Generation of a suite of 3D computer-generated breast phantoms from a limited set of human subject data

International Nuclear Information System (INIS)

Hsu, Christina M. L.; Palmeri, Mark L.; Segars, W. Paul; Veress, Alexander I.; Dobbins, James T. III

2013-01-01

three human subject datasets, were used in a preliminary observer evaluation where four board certified breast radiologists with varying amounts of experience ranked the level of realism (from 1 =“fake” to 10 =“real”) of the simulated images. Results: The morphing technique was able to successfully generate new and unique morphed datasets from the original human subject data. The radiologists evaluated the realism of simulated mammograms generated from the morphed and unmorphed human subject datasets and scored the realism with an average ranking of 5.87 ± 1.99, confirming that overall the phantom image datasets appeared more “real” than “fake.” Moreover, there was not a significant difference (p > 0.1) between the realism of the unmorphed datasets (6.0 ± 1.95) compared to the morphed datasets (5.86 ± 1.99). Three of the four observers had overall average rankings of 6.89 ± 0.89, 6.9 ± 1.24, 6.76 ± 1.22, whereas the fourth observer ranked them noticeably lower at 2.94 ± 0.7. Conclusions: This work presents a technique that can be used to generate a suite of realistic computerized breast phantoms from a limited number of human subjects. This suite of flexible breast phantoms can be used for multimodality imaging research to provide a known truth while concurrently producing realistic simulated imaging data.

Weight and Glucose Reduction Observed with a Combination of Nutritional Agents in Rodent Models Does Not Translate to Humans in a Randomized Clinical Trial with Healthy Volunteers and Subjects with Type 2 Diabetes.

Directory of Open Access Journals (Sweden)

Rebecca J Hodge

Full Text Available Nutritional agents have modest efficacy in reducing weight and blood glucose in animal models and humans, but combinations are less well characterized. GSK2890457 (GSK457 is a combination of 4 nutritional agents, discovered by the systematic assessment of 16 potential components using the diet-induced obese mouse model, which was subsequently evaluated in a human study.In the diet-induced obese mouse model, GSK457 (15% w/w in chow given with a long-acting glucagon-like peptide -1 receptor agonist, exendin-4 AlbudAb, produced weight loss of 30.8% after 28 days of treatment. In db/db mice, a model of diabetes, GSK457 (10% w/w combined with the exendin-4 AlbudAb reduced glucose by 217 mg/dL and HbA1c by 1.2% after 14 days.GSK457 was evaluated in a 6 week randomized, placebo-controlled study that enrolled healthy subjects and subjects with type 2 diabetes to investigate changes in weight and glucose. In healthy subjects, GSK457 well tolerated when titrated up to 40 g/day, and it reduced systemic exposure of metformin by ~ 30%. In subjects with diabetes taking liraglutide 1.8 mg/day, GSK457 did not reduce weight, but it slightly decreased mean glucose by 0.356 mmol/L (95% CI: -1.409, 0.698 and HbAlc by 0.065% (95% CI: -0.495, 0.365, compared to placebo. In subjects with diabetes taking metformin, weight increased in the GSK457-treated group [adjusted mean % increase from baseline: 1.26% (95% CI: -0.24, 2.75], and mean glucose and HbA1c were decreased slightly compared to placebo [adjusted mean glucose change from baseline: -1.22 mmol/L (95% CI: -2.45, 0.01; adjusted mean HbA1c change from baseline: -0.219% (95% CI: -0.910, 0.472].Our data demonstrate remarkable effects of GSK457 in rodent models of obesity and diabetes, but a marked lack of translation to humans. Caution should be exercised with nutritional agents when predicting human efficacy from rodent models of obesity and diabetes.ClinicalTrials.gov NCT01725126.

Suitability of Nicotiana tabacum 'Bel W3' for biomonitoring ozone in Sao Paulo, Brazil

International Nuclear Information System (INIS)

Sant'Anna, Silvia M.R.; Esposito, Marisia P.; Domingos, Marisa; Souza, Silvia R.

2008-01-01

Nicotiana tabacum 'Bel W3' is a widely used sensitive bioindicator for ambient ozone, but it is rarely used in tropical countries. Our goal was to determine the suitability of this plant for biomonitoring ozone in the city of Sao Paulo by evaluating the relationships between leaf necroses and ozone under field conditions and measurements of chlorophyll a fluorescence and antioxidants in plants exposed to different concentrations of ozone in closed chambers. While a weak linear relationship between leaf injury and ozone concentrations (R 2 = 0.10) was determined in the field, a strong linear relationship was observed in the chamber experiments. Maximum leaf injury was observed in plants submitted to 40 ppb, which coincided with a significant decrease in fluorescence and total ascorbic acid. The relationship between leaf damage observed in the field and ozone was improved when the concentrations were limited to 40 ppb (R 2 = 0.28). - Nicotiana tabacum 'Bel W3' is suitable for indicating low ozone levels in Brazil

Reporting of ethical protection in recent oral and maxillofacial surgery research involving human subjects.

Science.gov (United States)

Pitak-Arnnop, P; Sader, R; Hervé, C; Dhanuthai, K; Bertrand, J-Ch; Hemprich, A

2009-07-01

This retrospective observational study investigated the frequency of reporting ethical approval and informed consent in recently published oral and maxillofacial surgery (OMS) research involving human subjects. All research involving human subjects published in the International Journal of Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, British Journal of Oral and Maxillofacial Surgery, and Journal of Cranio-Maxillofacial Surgery during January to June 2005-2007 were analysed for disclosure of ethical approval by a local ethical committee and obtaining informed consent from the subjects. 534 articles were identified; ethical approval was documented in 118 (22%) and individual patient consent in 135 (25%). 355 reports (67%) did not include a statement on ethical approval or informed consent and only 74 reports (14%) disclosed statements of both. Ethical documentation in retrospective and observational studies was scant; 12% of randomised controlled trials and 38% of non-random trials did not report both of ethical protections. Most recent OMS publications involving humans failed to mention ethical review or subjects' consent. Authors must adhere to the international research ethics guidelines and journal instructions, while editors should play a gatekeeper role to protect research participants, uphold scientific integrity and maintain public trust in the experimental process and OMS profession.

Impact Response Comparison Between Parametric Human Models and Postmortem Human Subjects with a Wide Range of Obesity Levels.

Science.gov (United States)

Zhang, Kai; Cao, Libo; Wang, Yulong; Hwang, Eunjoo; Reed, Matthew P; Forman, Jason; Hu, Jingwen

2017-10-01

Field data analyses have shown that obesity significantly increases the occupant injury risks in motor vehicle crashes, but the injury assessment tools for people with obesity are largely lacking. The objectives of this study were to use a mesh morphing method to rapidly generate parametric finite element models with a wide range of obesity levels and to evaluate their biofidelity against impact tests using postmortem human subjects (PMHS). Frontal crash tests using three PMHS seated in a vehicle rear seat compartment with body mass index (BMI) from 24 to 40 kg/m 2 were selected. To develop the human models matching the PMHS geometry, statistical models of external body shape, rib cage, pelvis, and femur were applied to predict the target geometry using age, sex, stature, and BMI. A mesh morphing method based on radial basis functions was used to rapidly morph a baseline human model into the target geometry. The model-predicted body excursions and injury measures were compared to the PMHS tests. Comparisons of occupant kinematics and injury measures between the tests and simulations showed reasonable correlations across the wide range of BMI levels. The parametric human models have the capability to account for the obesity effects on the occupant impact responses and injury risks. © 2017 The Obesity Society.

Primary production measurements at three reservoirs in the state of Sao Paulo, Brazil

International Nuclear Information System (INIS)

Jureidini, P.; Chinez, S.J.; Agudo, E.G.

1983-01-01

Primary production measurements were carried out at three reservoirs in the state of Sao Paulo, Barra Bonita, Paiva Castro and Ponte nova using the 14 C technique. Meanwhile, several physical and chemical parameters of these water were also evaluated, in order to find out the limnological conditions of these reservoirs. Primary production rates ranged from 7,6mg C/m 3 d at Ponte Nova, to 247,2mg C/m 3 d at Barra Bonita. There seems to be god correlation between water quality data and primary production measurements. Regarding the results, it may be stated that the Barra Bonita reservoir has reached the eutrophic level, while the other two exibit mesotrophic levels. As a way of testing the water quality data collected was used in Churchill and Nicholas model, issuing results in agreement with those of the primary production measurements. (Author) [pt

La llegada de la peste al Estado de Sao Paulo en 1899

OpenAIRE

Nascimento, Dilene Raimundo do

2011-01-01

En octubre de 1899, la peste bubónica llegó a Brasil, por el puerto de Santos. Ciudad paulista de intenso flujo portuario fue la puerta de entrada de la epidemia de peste que asoló varias ciudades brasileñas a comienzos del siglo XX. Esta epidemia fue propulsora de una acción conjunta de varios estados para combatirla y, más que eso, ante las dificultades de importación de suero preparado en Europa, llevó a la creación, en 1899, del Instituto Butantan en Sao Paulo, y, en 1900, del Instituto S...

Mineralogical characterization of historical portuguese wall tiles of Sao Luis, Maranhao, Brazil

International Nuclear Information System (INIS)

Rivas Mercury, J.M.; Vasconcelos, N.S.L.S.; Cabral, A.A.; Pereira, D.J. Costa; Angelica, R.S.

2010-01-01

Portuguese wall tiles from centuries, XVII, XVIII and XIX, found in Sao Luis Maranhao has been studied by X-ray diffraction, in order to interpret the possible raw material and burning temperature. The mineral phases, Quartz, Wollastonite, Calcite and Gehlenite were identified in all samples. Based on the results it is possible to affirm that the main raw materials used to manufacture this materials was probably mixtures of kaolinite clay and calcite. Based on the mineralogical information it was also possible to state that burning temperature of this wall tiles was lower than 1000 deg C. (author)

Administration of ionizing radiation to human subjects in medical research

International Nuclear Information System (INIS)

1985-01-01

Any administration of ionizing radiation to human subjects for the purposes of diagnostic or therapeutic research involving either irradiation or the administration of radionuclides, should be undertaken only after approval by an institutional ethics committee. The ethics committee should obtain advice from a person experienced in radiation protection before granting approval. The research proposal must conform to regulatory requirements relating to the use of ionizing radiation

Analysis of angiotensin II binding to human platelets: Differences in young and old subjects

International Nuclear Information System (INIS)

Siebers, M.J.; Goodfriend, T.L.; Ball, D.; Elliott, M.E.

1990-01-01

We examined the binding of radiolabeled angiotensin II (AII) to human platelets to characterize the apparent increase in AII receptors observed in older subjects. At 22 degrees C, the amount of radioactivity associated with platelets from older subjects increased continuously for more than 2 hours. The same amount of radioactivity was displaced by addition of unlabeled AII at 30 min and 60 min. In the presence of phenylarsine oxide, in the cold, or when labeled antagonist was the ligand, binding came to equilibrium by 30 min. High pressure liquid chromatography demonstrated that 125 I-AII was the major radioactive compound in the supernatant and platelets after incubation, but the platelets also contained radiolabeled AII fragments. Thus, some degradation accompanied interaction of AII and platelets. Phenylarsine oxide did not prevent degradation of bound AII, suggesting that degradation precedes internalization. On average, maximum binding was greater in older subjects whether platelets were incubated with 125 I-AII alone, with 125 I-AII and phenylarsine oxide to prevent internalization, or when the competitive inhibitor 125 I-sar1,ile8-AII was the radioligand. Variability of binding among subjects also increased with age. Thus, platelets bind, degrade, and internalize AII, and the three processes occur to a greater extent in platelets from some, but not all older subjects

Acid rain: a case study at the Universidade de Sao Paulo campus, Sao Paulo State, Brazil; Chuva acida: estudo de caso no campus USP/SP

Energy Technology Data Exchange (ETDEWEB)

Galvao, Patricia

1997-12-31

The phenomena called acid rain is considered, by many researchers, one of the most serious environmental problem. This work has the aim of showing, in a theoretical and practical study, the problems caused by the atmospheric-pollutant emission, through natural or anthropogenic sources. In a period of 1 year (nov/94-nov/95), it was realized a practical work on rainwater, which consisted of collecting and, afterwards, analysing some physical and chemical parameters of this water, such as acidity, ionic concentrations, etc, with the purpose of characterizing the rainwater in Cidade Universitaria (SP, Brazil). After ending the practical part, it was possible to observe a 1,236.71 mm/y pluviosity, characterized by rainy summer and dry winter. The chemical-constituent-concentration analysis show us the predominance of SO{sup 2-}{sub 4} and Ca{sup 2+}, and a continental-origin water). The region of sao Paulo (Brazil), site of this study, is one of the largest metropolitan and industrialized areas of the world, which includes 18 million people, beside to an enormous industrial and vehicular complex. The acidity in the rain water is a complex problem and it must be treated by a range of disciplines to have a better comprehension of the cause/effects of the acid rain. (author) 96 refs., 28 figs., 4 tabs.

Acid rain: a case study at the Universidade de Sao Paulo campus, Sao Paulo State, Brazil; Chuva acida: estudo de caso no campus USP/SP

Energy Technology Data Exchange (ETDEWEB)

Galvao, Patricia

1996-12-31

The phenomena called acid rain is considered, by many researchers, one of the most serious environmental problem. This work has the aim of showing, in a theoretical and practical study, the problems caused by the atmospheric-pollutant emission, through natural or anthropogenic sources. In a period of 1 year (nov/94-nov/95), it was realized a practical work on rainwater, which consisted of collecting and, afterwards, analysing some physical and chemical parameters of this water, such as acidity, ionic concentrations, etc, with the purpose of characterizing the rainwater in Cidade Universitaria (SP, Brazil). After ending the practical part, it was possible to observe a 1,236.71 mm/y pluviosity, characterized by rainy summer and dry winter. The chemical-constituent-concentration analysis show us the predominance of SO{sup 2-}{sub 4} and Ca{sup 2+}, and a continental-origin water). The region of sao Paulo (Brazil), site of this study, is one of the largest metropolitan and industrialized areas of the world, which includes 18 million people, beside to an enormous industrial and vehicular complex. The acidity in the rain water is a complex problem and it must be treated by a range of disciplines to have a better comprehension of the cause/effects of the acid rain. (author) 96 refs., 28 figs., 4 tabs.

Phurcalite and others secondary uranium minerals from Perus, Sao Paulo, Brazil

International Nuclear Information System (INIS)

Atencio, D.

1991-01-01

Phurcalite has been found filling fractures in the tourmaline-bearing granitic pegmatite of Perus, in the north-west part of Sao Paulo city, Brazil. It forms aggregates of radiating euhedral crystals up to 5 mm in length. The crystals are bright yellow, transparent and display vitreous to adamantine lustre. Its streak is pale yellow. Phurcalite is brittle, with a conchoidal fracture, and non-fluorescent. The crystal structure of phurcalite has been solves by single-crystal x-ray diffraction methods and refined to R = 3.8% using 2065 observed [I > 3σ(I)] reflections. The structure consists of [(U O 2 ) 3 O 2 (P O 4 ) 2 4n- ] n layers, parallel to (010), connected by Ca 2+ ions and H 2 O. The coordination polyhedra are: for U(1) hexagonal bi pyramid; for U(2) and U(3) pentagonal bi pyramids; for Ca(4) and Ca(5) capped trigonal prism and triangulated dodecahedron, respectively; and for P(6) and P(7) tetrahedra. As a consequence of this work, the molecular formula of phurcalite previously reported as Ca 2 (U O 2 ) 3 (P O 4 ) 2 (OH) 4 .4 H 2 O must be changed to Ca 2 (U O 2 ) 3 O 2 (P O 4 ) 2 .7 H 2 O. Other secondary uranium minerals associated with Perus phurcalite are autunite, torbernite, meta-autunite, meta-torbernite, chernikovite, meta-uranocircite I, phosphuranylite, uranophane-alpha, uranophane-beta, haiweeite, barian week site and perhaps also bassetite, meta-tyuyamunite and meta-haiweeite. Opal, tridymite, cristobalite, secondary quartz, saponite and rhodochrosite occur associated to the uranium minerals. (author)

Rocks age and metamorphic occurrence from the southeastern part of Sao Paulo State and their crustal evaluation

International Nuclear Information System (INIS)

Tassinari, C.C.G.

1988-01-01

Pb-Pb and Rb-Sr whole rock isotope systematics and U-Pb on zircons method analyses are reported for rocks from the southeastern part of Sao Paulo state Brazil. The isotopic studies on granitic intrusions, orthogneissic rocks and migmatitic terranes, in this area, provides an important indication of the age and nature of the continental crust. (author) [pt

From the Philosophy of Consciousness to the Philosophy of Difference: The Subject for Education after Humanism

Science.gov (United States)

Zhao, Guoping

2015-01-01

Biesta has suggested that education after humanism should be interested in existence, not essence, in what the subject can do, not in what the subject is--the truth about the subject--and this is the way inspired by Foucault and Levinas. In this article, I analyze Foucault's alleged deconstruction and reconfiguration of the subject and Levinas'…

Psilocybin links binocular rivalry switch rate to attention and subjective arousal levels in humans.

Science.gov (United States)

Carter, Olivia L; Hasler, Felix; Pettigrew, John D; Wallis, Guy M; Liu, Guang B; Vollenweider, Franz X

2007-12-01

Binocular rivalry occurs when different images are simultaneously presented to each eye. During continual viewing of this stimulus, the observer will experience repeated switches between visual awareness of the two images. Previous studies have suggested that a slow rate of perceptual switching may be associated with clinical and drug-induced psychosis. The objective of the study was to explore the proposed relationship between binocular rivalry switch rate and subjective changes in psychological state associated with 5-HT2A receptor activation. This study used psilocybin, the hallucinogen found naturally in Psilocybe mushrooms that had previously been found to induce psychosis-like symptoms via the 5-HT2A receptor. The effects of psilocybin (215 microg/kg) were considered alone and after pretreatment with the selective 5-HT2A antagonist ketanserin (50 mg) in ten healthy human subjects. Psilocybin significantly reduced the rate of binocular rivalry switching and increased the proportion of transitional/mixed percept experience. Pretreatment with ketanserin blocked the majority of psilocybin's "positive" psychosis-like hallucinogenic symptoms. However, ketanserin had no influence on either the psilocybin-induced slowing of binocular rivalry or the drug's "negative-type symptoms" associated with reduced arousal and vigilance. Together, these findings link changes in binocular rivalry switching rate to subjective levels of arousal and attention. In addition, it suggests that psilocybin's effect on binocular rivalry is unlikely to be mediated by the 5-HT2A receptor.

The motor cortex drives the muscles during walking in human subjects

DEFF Research Database (Denmark)

Petersen, Tue Hvass; Willerslev-Olsen, Maria; Conway, B A

2012-01-01

Indirect evidence that the motor cortex and the corticospinal tract contribute to the control of walking in human subjects has been provided in previous studies. In the present study we used coherence analysis of the coupling between EEG and EMG from active leg muscles during human walking...... area and EMG from the anterior tibial muscle was found in the frequency band 24–40 Hz prior to heel strike during the swing phase of walking. This signifies that rhythmic cortical activity in the 24–40 Hz frequency band is transmitted via the corticospinal tract to the active muscles during walking...

Survival After Ventricular Fibrillation Cardiac Arrest in the Sao Paulo Metropolitan Subway System: First Successful Targeted Automated External Defibrillator (AED) Program in Latin America.

Science.gov (United States)

Gianotto-Oliveira, Renan; Gonzalez, Maria Margarita; Vianna, Caio Brito; Monteiro Alves, Maurício; Timerman, Sergio; Kalil Filho, Roberto; Kern, Karl B

2015-10-09

Targeted automated external defibrillator (AED) programs have improved survival rates among patients who have an out-of-hospital cardiac arrest (OHCA) in US airports, as well as European and Japanese railways. The Sao Paulo (Brazil) Metro subway carries 4.5 million people per day. A targeted AED program was begun in the Sao Paulo Metro with the objective to improve survival from cardiac arrest. A prospective, longitudinal, observational study of all cardiac arrests in the Sao Paulo Metro was performed from September 2006 through November 2012. This study focused on cardiac arrest by ventricular arrhythmias, and the primary endpoint was survival to hospital discharge with minimal neurological impairment. A total of 62 patients had an initial cardiac rhythm of ventricular fibrillation. Because no data on cardiac arrest treatment or outcomes existed before beginning this project, the first 16 months of the implementation was used as the initial experience and compared with the subsequent 5 years of full operation. Return of spontaneous circulation was not different between the initial 16 months and the subsequent 5 years (6 of 8 [75%] vs. 39 of 54 [72%]; P=0.88). However, survival to discharge was significantly different once the full program was instituted (0 of 8 vs. 23 of 54 [43%]; P=0.001). Implementation of a targeted AED program in the Sao Paulo Metro subway system saved lives. A short interval between arrest and defibrillation was key for good long-term, neurologically intact survival. These results support strategic expansion of targeted AED programs in other large Latin American cities. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

Night-vision goggles for night-blind subjects : subjective evaluation after 2 years of use

NARCIS (Netherlands)

Hartong, D. T.; Kooijman, A. C.

Purpose: To evaluate the usefulness of night-vision goggles (NVG) for night-blind subjects after 1 and 2 years of use. Methods: Eleven night-blind subjects with retinitis pigmentosa used NVG for a 2-year period. At the end of each year, they were requested to fill-in two questionnaires regarding

Designing oversight for nanomedicine research in human subjects: systematic analysis of exceptional oversight for emerging technologies

International Nuclear Information System (INIS)

Wolf, Susan M.; Jones, Cortney M.

2011-01-01

The basic procedures and rules for oversight of U.S. human subjects research have been in place since 1981. Certain types of human subjects research, however, have provoked creation of additional mechanisms and rules beyond the Department of Health and Human Services (DHHS) Common Rule and Food and Drug Administration (FDA) equivalent. Now another emerging domain of human subjects research—nanomedicine—is prompting calls for extra oversight. However, in 30 years of overseeing research on human beings, we have yet to specify what makes a domain of scientific research warrant extra oversight. This failure to systematically evaluate the need for extra measures, the type of extra measures appropriate for different challenges, and the usefulness of those measures hampers efforts to respond appropriately to emerging science such as nanomedicine. This article evaluates the history of extra oversight, extracting lessons for oversight of nanomedicine research in human beings. We argue that a confluence of factors supports the need for extra oversight, including heightened uncertainty regarding risks, fast-evolving science yielding complex and increasingly active materials, likelihood of research on vulnerable participants including cancer patients, and potential risks to others beyond the research participant. We suggest the essential elements of the extra oversight needed.

Designing oversight for nanomedicine research in human subjects: systematic analysis of exceptional oversight for emerging technologies

Science.gov (United States)

Wolf, Susan M.; Jones, Cortney M.

2011-04-01

The basic procedures and rules for oversight of U.S. human subjects research have been in place since 1981. Certain types of human subjects research, however, have provoked creation of additional mechanisms and rules beyond the Department of Health & Human Services (DHHS) Common Rule and Food and Drug Administration (FDA) equivalent. Now another emerging domain of human subjects research—nanomedicine—is prompting calls for extra oversight. However, in 30 years of overseeing research on human beings, we have yet to specify what makes a domain of scientific research warrant extra oversight. This failure to systematically evaluate the need for extra measures, the type of extra measures appropriate for different challenges, and the usefulness of those measures hampers efforts to respond appropriately to emerging science such as nanomedicine. This article evaluates the history of extra oversight, extracting lessons for oversight of nanomedicine research in human beings. We argue that a confluence of factors supports the need for extra oversight, including heightened uncertainty regarding risks, fast-evolving science yielding complex and increasingly active materials, likelihood of research on vulnerable participants including cancer patients, and potential risks to others beyond the research participant. We suggest the essential elements of the extra oversight needed.

Trace element determination study in human hair by neutron activation analysis

International Nuclear Information System (INIS)

Frazao, Selma Violato

2008-01-01

Human hair analysis studies have been subject of continuous interest due to the fact that they can be used as an important tool to evaluate trace element levels in the human body. These determinations have been carried out to use hair for environmental and occupational monitoring, to identify intoxication or poisoning by toxic metals, to assess nutritional status, to diagnose and to prevent diseases and in forensic sciences. Although hair analysis presents several advantages over other human tissue or fluid analyses, such as organ tissue, blood, urine and saliva, there are some controversies regarding the use of hair analysis data. These controversies arise from the fact that it is difficult to establish reliable reference values for trace elements in hair. The purpose of this study was to evaluate the factors that affect element concentrations in hair samples from a population considered healthy and residing in the Sao Paulo metropolitan area. The collected human head hair was cut in small pieces, washed, dried and analyzed by neutron activation analysis (NAA). Aliquots of hair samples and synthetic elemental standards were irradiated at the IEA-R1 nuclear research reactor for 16 h under a thermal neutron flux of about 5x10 12 n cm -2 s -1 for As, Br, Ca, Co, Cr, Cs, Cu, Fe, K, La, Na, Sb, Sc, Se and Zn determinations. The induced gamma activities of the standards and samples were measured using a gamma ray spectrometer coupled to an hiperpure Ge detector. For quality control of the results, IAEA- 85 Human Hair and INCT-TL-1 Tea Leaves certified reference materials (CRMs) were analyzed. Results obtained in these CRMs presented for most of elements, good agreement with the values of the certificates (relative errors less than 10%) and good precision (variation coefficients less than 13.6%). Results of replicate hair sample analysis showed good reproducibility indicating homogeneity of the prepared sample. Results obtained in the analyses of dyed and non-dyed hair

The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day.

Science.gov (United States)

Clare, Bevin A; Conroy, Richard S; Spelman, Kevin

2009-08-01

Taraxacum officinale (L.) Weber (Asteraceae) has been extensively employed as a diuretic in traditional folk medicine and in modern phytotherapy in Europe, Asia, and the Americas without prior clinical trial substantiation. In this pilot study, a high-quality fresh leaf hydroethanolic extract of the medicinal plant T. officinale (dandelion) was ingested by volunteers to investigate whether an increased urinary frequency and volume would result. Volume of urinary output and fluid intake were recorded by subjects. Baseline values for urinary frequency and excretion ratio (urination volume:fluid intake) were established 2 days prior to dandelion dosing (8 mL TID) and monitored throughout a 1-day dosing period and 24 hours postdosing. For the entire population (n = 17) there was a significant (p officinale ethanolic extract shows promise as a diuretic in humans. Further studies are needed to establish the value of this herb for induction of diuresis in human subjects.

Endurance training enhances skeletal muscle interleukin-15 in human male subjects

DEFF Research Database (Denmark)

Rinnov, Anders; Yfanti, Christina; Nielsen, Søren

2014-01-01

Regular endurance exercise promotes metabolic and oxidative changes in skeletal muscle. Overexpression of interleukin-15 (IL-15) in mice exerts similar metabolic changes in muscle as seen with endurance exercise. Muscular IL-15 production has been shown to increase in mice after weeks of regular...... endurance running. With the present study we aimed to determine if muscular IL-15 production would increase in human male subjects following 12 weeks of endurance training. In two different studies we obtained plasma and muscle biopsies from young healthy subjects performing: (1) 12 weeks of ergometer...... weeks of regular endurance training induced a 40% increase in basal skeletal muscle IL-15 protein content (p...

Where are human subjects in Big Data research? The emerging ethics divide

Directory of Open Access Journals (Sweden)

Jacob Metcalf

2016-06-01

Full Text Available There are growing discontinuities between the research practices of data science and established tools of research ethics regulation. Some of the core commitments of existing research ethics regulations, such as the distinction between research and practice, cannot be cleanly exported from biomedical research to data science research. Such discontinuities have led some data science practitioners and researchers to move toward rejecting ethics regulations outright. These shifts occur at the same time as a proposal for major revisions to the Common Rule—the primary regulation governing human-subjects research in the USA—is under consideration for the first time in decades. We contextualize these revisions in long-running complaints about regulation of social science research and argue data science should be understood as continuous with social sciences in this regard. The proposed regulations are more flexible and scalable to the methods of non-biomedical research, yet problematically largely exclude data science methods from human-subjects regulation, particularly uses of public datasets. The ethical frameworks for Big Data research are highly contested and in flux, and the potential harms of data science research are unpredictable. We examine several contentious cases of research harms in data science, including the 2014 Facebook emotional contagion study and the 2016 use of geographical data techniques to identify the pseudonymous artist Banksy. To address disputes about application of human-subjects research ethics in data science, critical data studies should offer a historically nuanced theory of “data subjectivity” responsive to the epistemic methods, harms and benefits of data science and commerce.

Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation.

Directory of Open Access Journals (Sweden)

Carlos Sánchez

Full Text Available Human atrial electrophysiology exhibits high inter-subject variability in both sinus rhythm (SR and chronic atrial fibrillation (cAF patients. Variability is however rarely investigated in experimental and theoretical electrophysiological studies, thus hampering the understanding of its underlying causes but also its implications in explaining differences in the response to disease and treatment. In our study, we aim at investigating the ability of populations of human atrial cell models to capture the inter-subject variability in action potential (AP recorded in 363 patients both under SR and cAF conditions.Human AP recordings in atrial trabeculae (n = 469 from SR and cAF patients were used to calibrate populations of computational SR and cAF atrial AP models. Three populations of over 2000 sampled models were generated, based on three different human atrial AP models. Experimental calibration selected populations of AP models yielding AP with morphology and duration in range with experimental recordings. Populations using the three original models can mimic variability in experimental AP in both SR and cAF, with median conductance values in SR for most ionic currents deviating less than 30% from their original peak values. All cAF populations show similar variations in G(K1, G(Kur and G(to, consistent with AF-related remodeling as reported in experiments. In all SR and cAF model populations, inter-subject variability in I(K1 and I(NaK underlies variability in APD90, variability in I(Kur, I(CaL and I(NaK modulates variability in APD50 and combined variability in Ito and I(Kur determines variability in APD20. The large variability in human atrial AP triangulation is mostly determined by I(K1 and either I(NaK or I(NaCa depending on the model.Experimentally-calibrated human atrial AP models populations mimic AP variability in SR and cAF patient recordings, and identify potential ionic determinants of inter-subject variability in human atrial AP

76 FR 5735 - Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides

Science.gov (United States)

2011-02-02

... addressed in EPA science and ethics reviews of proposed and completed human research with pesticides, drawn..., which suggest ethical considerations relevant to evaluation of human studies. Third, Petitioners argued... Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides AGENCY...

[The physical therapy undergraduate students' responses to the gross human anatomy subjects].

Science.gov (United States)

Anahara, Reiko; Kawashiro, Yukiko; Matsuno, Yoshiharu; Mori, Chisato; Kohno, Toshihiko

2008-09-01

Instruction in gross human anatomy is one of the important items in the subject for co-medical students of the physical therapist course. The physical therapy undergraduate students are required to have a solid understanding of the structure and formation of the human body. Therefore, their good-understanding of the course on the gross human anatomy and their experience of the gross human anatomy laboratory (observation practice) are acquired to improve their knowledge of the human body. To clarify the student responses to the gross human anatomy course including the gross human anatomy laboratory, several questionnaires were administered to the freshman physical therapy undergraduate student for two years. We found that more than 80% of the students, who felt a negative attitude for gross human anatomy before the course started, had a positive attitude about the gross human anatomy after going through the course. The experience of the gross human anatomy laboratory increased the students' activity of learning and they thought more about the dignity of being human after the course than before viewing. In addition, the results suggested that the multiple experiences of the gross human anatomy course are useful for the physical therapy undergraduate students to improve the quality of their understanding of the human body.

Survey of elemental concentrations in lichen samples collected from Sao Paulo State

International Nuclear Information System (INIS)

Saiki, M.; Horimoto, L.K.; Vasconcellos, M.B.A.; Coccaro, D.M.B.; Marcelli, M.P.

2001-01-01

Samples of the lichen Canoparmelia texana collected in seven different sites of Sao Paulo State and one site of the Parana State were analysed by neutron activation analysis in order to obtain information on the air quality in these regions and also to select a region of interest for the evaluation of baseline level of elements in lichen species. Concentrations of the elements Al, As, Br, Ca, Cd, Cl, Co, Cs, Fe, Hf, K, Mg, Mn, Na, Rb, Sb, Sc, Se, Ti, Th, U, V, Zn and lanthanides were determined and a preliminary comparisons was made between the results obtained for samples collected in different sites. (author)

Evaluation of quality of clay used in red ceramic arising from the region of Baixo Sao Francisco - Sergipe (Brazil)

International Nuclear Information System (INIS)

Azevedo, T.F.; Andrade, C.E.C. de; Santos, C.R. dos; Griza, S.; Barreto, L.S.

2011-01-01

The activity of red ceramic production in the territory of the Baixo Sao Francisco, in Sergipe had its origin 20 years ago and involves the cities of Neopolis, Santana do Sao Francisco, Propria and Telha, marketed primarily for the State of Alagoas. The clay used is extracted in the flood plain of the River. The aim of this study was to evaluate the quality of clay used in the manufacture of ceramic blocks with and without addition of residue (5, 10 and 15%). Were used a clay composition of the industrial process. Measurements were made RD-X, TGA, plasticity index, retraction, absorption, mechanical strength. The samples were prepared by extrusion and treated at temperatures of 600 ° C, 800 ° C and 900 ° C. The results showed a significant reduction in the absorption, decrease with increasing temperature and plasticity indexes suitable for extrusion. The values of mechanical strength at 800 ° C and 900 ° C were higher than 1.5 MPa. (author)

Device orientation of a leadless pacemaker and subcutaneous implantable cardioverter-defibrillator in canine and human subjects and the effect on intrabody communication.

Science.gov (United States)

Quast, Anne-Floor B E; Tjong, Fleur V Y; Koop, Brendan E; Wilde, Arthur A M; Knops, Reinoud E; Burke, Martin C

2018-02-14

The development of communicating modular cardiac rhythm management systems relies on effective intrabody communication between a subcutaneous implantable cardioverter-defibrillator (S-ICD) and a leadless pacemaker (LP), using conducted communication. Communication success is affected by the LP and S-ICD orientation. This study is designed to evaluate the orientation of the LP and S-ICD in canine subjects and measure success and threshold of intrabody communication. To gain more human insights, we will explore device orientation in LP and S-ICD patients. Canine subjects implanted with a prototype S-ICD and LP (both Boston Scientific, MA, USA) with anterior-posterior fluoroscopy images were included in this analysis. For comparison, a retrospective analysis of human S-ICD and LP patients was performed. The angle of the long axis of the LP towards the vertical axis of 0°, and distance between the coil and LP were measured. Twenty-three canine subjects were analysed. Median angle of the LP was 29° and median distance of the S-ICD coil to LP was 0.8 cm. All canine subjects had successful communication. The median communicating threshold was 2.5 V. In the human retrospective analysis, 72 LP patients and 100 S-ICD patients were included. The mean angle of the LP was 56° and the median distance between the S-ICD coil and LP was 4.6 cm. Despite the less favourable LP orientation in canine subjects, all communication attempts were successful. In the human subjects, we observed a greater and in theory more favourable LP angle towards the communication vector. These data suggests suitability of human anatomy for conductive intrabody communication.

High altitude pulmonary edema and exercise at 4,400 meters on Mount McKinley. Effect of expiratory positive airway pressure.

Science.gov (United States)

Schoene, R B; Roach, R C; Hackett, P H; Harrison, G; Mills, W J

1985-03-01

Breathing against positive expiratory pressure has been used to improve gas exchange in many forms of pulmonary edema, and forced expiration against resistance during exercise has been advocated for climbing at high altitude as a method to optimize performance. To evaluate the effect of expiratory positive airway pressure (EPAP) on climbers with high altitude pulmonary edema (HAPE) and on exercise at high altitude, we studied four climbers with HAPE at rest and 13 healthy climbers during exercise on a bicycle ergometer at 4400 m. We measured minute ventilation (VI, L/min), arterial oxygen saturation (SaO2 percent), end-tidal carbon dioxide (PACO2, mm Hg), respiratory rate (RR), and heart rate (HR) during the last minute of a five minute interval at rest in the climbers with HAPE, and at rest, 300, and 600 kpm/minute workloads on a bicycle ergometer in the healthy subjects. The HAPE subjects demonstrated an increased SaO2 percent, no change in HR or VI, and a decrease in RR on EPAP as compared to control. In normal subjects, SaO2 percent, VI, and heart rate were significantly higher on EPAP 10 cm H2O than 0 cm H2O control (p less than 0.01, 0.01, and 0.05, respectively). The RR and PaCO2 were not significantly different. In summary, EPAP improves gas exchange in HAPE subjects at rest. The EPAP in normal subjects at high altitude resulted in a higher SaO2 percent at the expense of a higher VI and higher HR. These results suggest that the work of breathing is higher and the stroke volume lower on EPAP. The positive pressure mask may be an effective temporizing measure for victims of HAPE who cannot immediately go to a lower altitude.

Precambrian continental crustal evolution of Southeastern Sao Paulo state - Brazil: based on isotopic evidences

International Nuclear Information System (INIS)

Tassinari, C.C.G.

1988-01-01

The isotopic studies on granitic intrusions, orthogneissic rocks and migmatitic terranes in the Southeastern Sao Paulo are presented, indicating the age and the geochemical nature of the continental crust of this area. Approximately 300 Ar, Sr and Pb isotopic age determinations are included in this paper, categorized as to their reliability and significance. Looking for the continental crust growth related to the geological time, at the end of the lower Proterozoic, at least 85% of the continental crust has already accreted and differentiated. (C.G.C.)

The Impact of the Protection of Human Subjects on Research. Working Paper No. 70.

Science.gov (United States)

Halpern, Andrew S.

The author discusses the experimenter's responsibility for the protection of human subjects (such as the handicapped) in research and the impact of this responsibility on methods of doing research. Considered are the types of human rights that are most frequently in need of protection within a research setting (such as the right to privacy); the…

IN SITU density measurements oozy bottom of the access channel to the port of Santos, Sao Paulo, Brazil

International Nuclear Information System (INIS)

Minardi, P.S.P.

1988-09-01

The density of the bottom sediment of the access channel to the port of Santos, Sao Paulo, Brazil was measured. The in situ measurements aimed at verifying the use for navigation purposes of the layers with densities equal to or smaller than 1200 kg/m 3 . (F.E.). 3 refs, 55 figs, 3 tabs

Environmental radioactive monitoring in Itu, Sao Paulo, Brazil; Monitoramento de radioatividade ambiental no municipio de Itu

Energy Technology Data Exchange (ETDEWEB)

NONE

1990-01-01

The results of the environmental monitoring of a region near to a radioactive materials deposit in Sao Paulo State, Brazil, are presented. The radioactive materials are uranium and thorium hydroxides from monazite processing. The temporal variation of {sup 226} Ra was determined in the superficial and underground water, showing no increase for the former and a maximum concentration of 0,306 Bq/L for the latter. 21 figs., 17 tabs.

Dose absorbed in x-rays toraxicas executed in hospitals of the city of Sao Paulo Brazil

International Nuclear Information System (INIS)

Freitas, M.B.; Yoshimura, E.M.

1998-01-01

With the objective of evaluating the contribution of radiography exams in the dose received by the population of the city of Sao Paulo (Brazil), we made mensurations of the doses absorbed in toraxicas x-rays (projections PA and LAT) taken in several teams of rays X used in hospitals. The work is supplemented with demography data and the knowledge of the quantity of exams executed in each team

Unsteady-state human-body exergy consumption rate and its relation to subjective assessment of dynamic thermal environments

DEFF Research Database (Denmark)

Schweiker, Marcel; Kolarik, Jakub; Dovjak, Mateja

2016-01-01

of the present study confirmed previously indicated trends that lowest human body exergy consumption rate is associated with thermal sensation close to neutrality. Moreover, higher acceptability was in general associated with lower human body exergy consumption rate. (C) 2016 Elsevier B.V. All rights reserved.......Few examples studied applicability of exergy analysis on human thermal comfort. These examples relate the human-body exergy consumption rate with subjectively obtained thermal sensation votes and had been based on steady-state calculation methods. However, humans are rarely exposed to steady...... between the human-body exergy consumption rate and subjective assessment of thermal environment represented by thermal sensation as well as to extend the investigation towards thermal acceptability votes. Comparison of steady-state and unsteady-state model showed that results from both models were...

Parental Perspectives on a Pediatric Human Non-Subjects Biobank.

Science.gov (United States)

Brothers, Kyle B; Clayton, Ellen Wright

2012-01-01

BACKGROUND: Genomic biorepositories will be important tools to help unravel the effect of common genetic variants on risk for common pediatric diseases. Our objective was to explore how parents would respond to the inclusion of children in an opt-out model biobank. METHODS: We conducted semi-structured interviews with parents in hospital-based pediatric clinics. Participants responded to a description of a biorepository already collecting samples from adults. Two coders independently analyzed and coded interviews using framework analysis. Opt-out forms were later piloted in a clinic area. Parental opt-out choices were recorded electronically, with opt-out rates reported here. RESULTS: Parents strongly supported medical research in general and expressed a high level of trust that Vanderbilt University would keep their child's medical information private. Parents were more likely to allow their child's sample to be included in the biorepository than to allow their child to participate in a hypothetical study that would not help or harm their child, but might help other children. Only a minority were able to volunteer a concern raised by the description of the biobank. The opt-out rate was initially high compared with the opt-out rate in the adult biorepository, but after the first week decreased to near the baseline in adult clinics. CONCLUSION: Parents in our study generally support an opt-out model biobank in children. Most would allow their own child's sample to be included. Institutions seeking to build pediatric biobanks may consider the human non-subjects model as a viable alternative to traditional human-subjects biobanks.

Development and validation of a biomarker for diarrhea-predominant irritable bowel syndrome in human subjects.

Directory of Open Access Journals (Sweden)

Mark Pimentel

Full Text Available Diarrhea-predominant irritable bowel syndrome (IBS is diagnosed through clinical criteria after excluding "organic" conditions, and can be precipitated by acute gastroenteritis. Cytolethal distending toxin B (CdtB is produced by bacteria that cause acute gastroenteritis, and a post-infectious animal model demonstrates that host antibodies to CdtB cross-react with vinculin in the host gut, producing an IBS-like phenotype. Therefore, we assessed circulating anti-CdtB and anti-vinculin antibodies as biomarkers for D-IBS in human subjects. Subjects with D-IBS based on Rome criteria (n=2375 were recruited from a large-scale multicenter clinical trial for D-IBS (TARGET 3. Subjects with inflammatory bowel disease (IBD (n=142, subjects with celiac disease (n=121, and healthy controls (n=43 were obtained for comparison. Subjects with IBD and celiac disease were recruited based on the presence of intestinal complaints and histologic confirmation of chronic inflammatory changes in the colon or small intestine. Subjects with celiac disease were also required to have an elevated tTG and biopsy. All subjects were aged between 18 and 65 years. Plasma levels of anti-CdtB and anti-vinculin antibodies were determined by ELISA, and compared between groups. Anti-CdtB titers were significantly higher in D-IBS subjects compared to IBD, healthy controls and celiac disease (P<0.001. Anti-vinculin titers were also significantly higher in IBS (P<0.001 compared to the other groups. The area-under-the-receiver operating curves (AUCs were 0.81 and 0.62 for diagnosis of D-IBS against IBD for anti-CdtB and anti-vinculin, respectively. Both tests were less specific in differentiating IBS from celiac disease. Optimization demonstrated that for anti-CdtB (optical density≥2.80 the specificity, sensitivity and likelihood ratio were 91.6%, 43.7 and 5.2, respectively, and for anti-vinculin (OD≥1.68 were 83.8%, 32.6 and 2.0, respectively. These results confirm that anti-CdtB and

Pb/Pb isochron ages and Pb isotope geochemistry of Bambui Group carbonate rocks from the southern portion of the Sao Francisco Basin

International Nuclear Information System (INIS)

Babinski, M.

1993-01-01

This study involves the establishment of chemical and analytical procedure for Pb/Pb dating of Neo proterozoic carbonate rocks and their application to obtaining isochron ages of Bambui Group rocks from the southern portion of the Sao Francisco Basin, Minas Gerais State. The Pb isotopic compositions and U and Pb concentrations determined on more than 90 samples (≅ 600 analyses) from Sete Lagoas do Jacare formations, Bambui Group, from different parts of the basin, showed four distinct types of Pb, here called types I, II, III and IV. Type I Pb was found in samples with low Pb concentrations and relatively high U concentrations. Type II Pb is present in samples with relatively high Pb concentrations and low U concentrations it is non-radiogenic crustal Pb. Type III Pb is also found in samples with high Pb concentrations and low U concentrations but it is radiogenic crustal Pb. Type IV Pb occurs in samples with U/Pb ratios lower than 1 and is intermediate in composition between Type III and Type I Pb. According to the data presented in this paper it is suggested that carbonate rocks from Sete Lagoas Formations were deposited before 686±69 Ma. Rocks from the Lagoa do Jacare Formation, contained only Type II Pb, which does not permit determination of a Pb/Pb age. During the interval from 690 to 500 Ma, the Pb isotope system of the carbonate rocks from the Sao Francisco Basin was disturbed, and in some areas it was totally reset. The imprecise U/Pb ages of 550-600 Ma obtained from some of the carbonate rocks reflect this disturbance. The ages determined in this study are in agreement with most of the published ages of the tectonism from the Brasiliano fold belts marginal to Sao Francisco Craton, showing that the isotopic systems of Sao Francisco Basin rocks were largely affected by brasiliano tectonism. (author)

Indirect detection of an epitope-specific response to HIV-1 gp120 immunization in human subjects.

Directory of Open Access Journals (Sweden)

Evgeny Shmelkov

Full Text Available A specific response of human serum neutralizing antibodies (nAb to a conformational epitope as a result of vaccination of human subjects with the surface envelope glycoprotein (gp120 of HIV-1 has not previously been documented. Here, we used computational analysis to assess the epitope-specific responses of human subjects, which were immunized with recombinant gp120 immunogens in the VAX003 and VAX004 clinical trials. Our computational methodology--a variation of sieve analysis--compares the occurrence of specific nAb targeted conformational 3D epitopes on viruses from infected individuals who received vaccination to the occurrence of matched epitopes in the viruses infecting placebo subjects. We specifically studied seven crystallographically defined nAb targeted conformational epitopes in the V3 loop, an immunogenic region of gp120. Of the six epitopes present in the immunogens and targeted by known monoclonal neutralizing antibodies, only the one targeted by the anti-V3 nAb 2219 exhibited a significant reduction in occurrence in vaccinated subjects compared to the placebo group. This difference occurred only in the VAX003 Thailand cohort. No difference was seen between vaccinated and placebo groups for the occurrence of an epitope that was not present in the immunogen. Thus, it can be theorized that a specific 2219-like human neutralizing antibody immune response to AIDSVAX immunization occurred in the VAX003 cohort, and that this response protected subjects from a narrow subset of HIV-1 viruses circulating in Thailand in the 1990s and bearing the conformational epitope targeted by the neutralizing antibody 2219.

Paleoproterozoic source contributions to the Sao Roque Group sedimentation: LA-MC-ICPMS U-Pb dating and Sm-Nd systematics of clasts from metaconglomerates of the Boturuna Formation

Energy Technology Data Exchange (ETDEWEB)

Henrique-Pinto, Renato; Janasi, Valdecir de Assis; Tassinari, Colombo Celso Gaeta [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Geociencias. Dept. de Mineralogia e Geotectonica; Simonetti, Antonio [University of Notre Dame, South Bend (United States). Dept. of Civil Engineering and Geological Sciences; Heaman, Larry Michael, E-mail: renatohp@usp.br, E-mail: vajanasi@usp.br, E-mail: ccgtassi@usp.br, E-mail: antonio.simonetti.3@nd.edu, E-mail: larry.heaman@ualberta.ca [University of Alberta, Edmonton (Canada). Dept. of Earth and Atmospheric Sciences

2012-12-15

The Sao Roque Group is characterized by volcano-sedimentary sequences, in which deposition probably started in the late Paleoproterozoic. U-Pb dating by LA-MC-ICPMS of zircons extracted from predominantly equigranular monzogranites clasts from Morro Doce and Morro do Polvilho regions, yield paleoproterozoic ages of 2199 {+-}8.5 Ma and 2247 {+-}13 Ma, respectively. These represent the ages for the main source of granite for the metaconglomerates from the Boturuna Formation (basal unit of Sao Roque Group). Its polycyclic history is reinforced by the presence of inherited Archean zircons (2694 {+-}29 Ma) found within the clasts. Moreover, these clasts have also been affected by the Neoproterozoic overprinting event as indicated by their lower intercept Concordia ages. Sm-Nd isotope data for the main clast varieties from the Morro Doce metaconglomerates yield T{sub DM} ages of 2.6 to 2.7 Ga, demonstrating that these granites are the recycling products of an Archean crustal component. The metaconglomerate arkosean framework yields slightly lower {epsilon}{sub Nd(t)} values than those for the clasts, indicating that a younger and/or more primitive source also contributed to the Boturuna Formation. (author)

Microarray expression profiling of human dental pulp from single subject.

Science.gov (United States)

Tete, Stefano; Mastrangelo, Filiberto; Scioletti, Anna Paola; Tranasi, Michelangelo; Raicu, Florina; Paolantonio, Michele; Stuppia, Liborio; Vinci, Raffaele; Gherlone, Enrico; Ciampoli, Cristian; Sberna, Maria Teresa; Conti, Pio

2008-01-01

Microarray is a recently developed simultaneous analysis of expression patterns of thousand of genes. The aim of this research was to evaluate the expression profile of human healthy dental pulp in order to find the presence of genes activated and encoding for proteins involved in the physiological process of human dental pulp. We report data obtained by analyzing expression profiles of human tooth pulp from single subjects, using an approach based on the amplification of the total RNA. Experiments were performed on a high-density array able to analyse about 21,000 oligonucleotide sequences of about 70 bases in duplicate, using an approach based on the amplification of the total RNA from the pulp of a single tooth. Obtained data were analyzed using the S.A.M. system (Significance Analysis of Microarray) and genes were merged according to their molecular functions and biological process by the Onto-Express software. The microarray analysis revealed 362 genes with specific pulp expression. Genes showing significant high expression were classified in genes involved in tooth development, protoncogenes, genes of collagen, DNAse, Metallopeptidases and Growth factors. We report a microarray analysis, carried out by extraction of total RNA from specimens of healthy human dental pulp tissue. This approach represents a powerful tool in the study of human normal and pathological pulp, allowing minimization of the genetic variability due to the pooling of samples from different individuals.

Mechanical work as an indirect measure of subjective costs influencing human movement.

Directory of Open Access Journals (Sweden)

Karl E Zelik

Full Text Available To descend a flight of stairs, would you rather walk or fall? Falling seems to have some obvious disadvantages such as the risk of pain or injury. But the preferred strategy of walking also entails a cost for the use of active muscles to perform negative work. The amount and distribution of work a person chooses to perform may, therefore, reflect a subjective valuation of the trade-offs between active muscle effort and other costs, such as pain. Here we use a simple jump landing experiment to quantify the work humans prefer to perform to dissipate the energy of landing. We found that healthy normal subjects (N = 8 preferred a strategy that involved performing 37% more negative work than minimally necessary (P<0.001 across a range of landing heights. This then required additional positive work to return to standing rest posture, highlighting the cost of this preference. Subjects were also able to modulate the amount of landing work, and its distribution between active and passive tissues. When instructed to land softly, they performed 76% more work than necessary (P<0.001, with a higher proportion from active muscles (89% vs. 84%, P<0.001. Stiff-legged landings, performed by one subject for demonstration, exhibited close to the minimum of work, with more of it performed passively through soft tissue deformations (at least 30% in stiff landings vs. 16% preferred. During jump landings, humans appear not to minimize muscle work, but instead choose to perform a consistent amount of extra work, presumably to avoid other subjective costs. The degree to which work is not minimized may indirectly quantify the relative valuation of costs that are otherwise difficult to measure.

Investigating environmental determinants of diet, physical activity, and overweight among adults in Sao Paulo, Brazil.

Science.gov (United States)

Jaime, Patricia Constante; Duran, Ana Clara; Sarti, Flávia Mori; Lock, Karen

2011-06-01

There is worldwide recognition that the burden of noncommunicable diseases (NCDs) and obesity-related health problems is rapidly increasing in low- and middle-income countries. Environmental determinants of obesity are likely to differ between countries, particularly in those undergoing rapid socioeconomic and nutrition transitions such as Brazil. This study aims to describe some built environment and local food environment variables and to explore their association with the overweight rate and diet and physical activity area-level aggregated indicators of adults living in the city of Sao Paulo, the largest city in Brazil. This formative study includes an ecological analysis of environmental factors associated with overweight across 31 submunicipalities of the city of Sao Paulo using statistical and spatial analyses. Average prevalence of overweight was 41.69% (95% confidence interval 38.74, 44.64), ranging from 27.14% to 60.75% across the submunicipalities. There was a wide geographical variation of both individual diet and physical activity, and indicators of food and built environments, favoring wealthier areas. After controlling for area socioeconomic status, there was a positive correlation between regular fruits and vegetables (FV) intake and density of FV specialized food markets (r = 0.497; p fast-food restaurant density and overweight prevalence was found. A negative association between overweight prevalence and density of parks and public sport facilities was seen (r = -0.527; p food access and health inequalities.

Human skeletal muscle perilipin 2 and 3 expression varies with insulin sensitivity

DEFF Research Database (Denmark)

Vigelsø Hansen, Andreas; Prats Gavalda, Clara; Ploug, Thorkil

2013-01-01

Background: Impaired insulin sensitivity may partly arise from a dysregulated lipid metabolism in human skeletal muscle. This study investigates the expression levels of perilipin 2, 3, and 5, and four key lipases in human skeletal muscle from the subjects that exhibit a range from normal to very...

Urban index modelling for forecasting of channeled natural gas market: an example in Sao Paulo metropolitan region; Modelagem de indicadores urbanos para previsao do mercado de gas natural canalizado: um exemplo na regiao metropolitana de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Massara, Vanessa Meloni; Faga, Murilo Tadeu Werneck; Udaeta, Miguel Edgar Morales [Universidade Sao Paulo (USP), SP (Brazil). Programa Interunidades de Pos Graduacao em Energia]. E-mail: vmassara@iee.usp.br; murfaga@iee.usp.br; udaeta@pea.usp.br

2006-07-01

This paper aims to present a systemic model for analysis of the expansion and grow up of the natural gas distribution pipeline in a city. This methodology integrates the understanding of the urban dynamics to the strategies of expansion in the natural gas distribution network, through the grouping of information such as family income, demographic density and construction area, percentage of land use, number of households as well as commercial, service and industrial establishments, number of real state as well as indicative information released by the Urban Plan of the city regarding the increments in the peripheral districts. Relating the gas consumption esteemed by each type of land occupation and the cost for expanding the gas distribution network, the model will indicate, for each neighborhood, the viability of implementing a gas network as well as the places with potential for growing density in the existing gas distribution system. The aim is to propose an integration of aspects of city dynamics and new energy source development, taking the advance of natural gas in Sao Paulo Metropolitan area as a specific case study. Through the analysis of highly industrialized, residential and commercial suburbs of the City of Sao Caetano do Sul, the importance of urban parameters in the decision making process for network expansion is identified. (author)

Elaboration, publication and implementation of a technical regulation of radiological protection at the State of Sao Paulo

International Nuclear Information System (INIS)

Aldred, Martha Aurelia; Eduardo, Maria Bernardete de Paula

1996-01-01

Technological improvements of new equipment and some new topics of the international recommendations from ICRP 60 (1990) are considered in a meeting of radiation protection experts and representatives of professionals involved with the use of ionizing radiation in health care services. As a result a new regulation is proposed to the Sao Paulo State Health Department (Brazil). The importance of performing a quality assurance program is emphasized

Post-approval monitoring and oversight of U.S.-initiated human subjects research in resource-constrained countries.

Science.gov (United States)

Brown, Brandon; Kinsler, Janni; Folayan, Morenike O; Allen, Karen; Cáceres, Carlos F

2014-06-01

The history of human subjects research and controversial procedures in relation to it has helped form the field of bioethics. Ethically questionable elements may be identified during research design, research implementation, management at the study site, or actions by a study's investigator or other staff. Post-approval monitoring (PAM) may prevent violations from occurring or enable their identification at an early stage. In U.S.-initiated human subjects research taking place in resource-constrained countries with limited development of research regulatory structures, arranging a site visit from a U.S. research ethics committee (REC) becomes difficult, thus creating a potential barrier to regulatory oversight by the parent REC. However, this barrier may be overcome through the use of digital technologies, since much of the world has at least remote access to the Internet. Empirical research is needed to pilot test the use of these technologies for research oversight to ensure the protection of human subjects taking part in research worldwide.

Radiation protection in radiology services in the municipality of Sao Paulo, SP, Brazil; Protecao radiologica nos servicos de radiologia do Municipio de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Senise, Paulo H.; Silva, Ezequiel; Ruzene, Anderson A.; Braga, Adriano C.; Spirgatis, Armim, E-mail: paulo.senise@fidi.org.br, E-mail: ezequieI.siIva@fidi.org.br, E-mail: anderson.ruzene@fidi.org.br, E-mail: adriano.braga@fidi.org.br, E-mail: armim.spirgatis@fidi.org.br [Fundacao lnstituto de Pesquisa e Estudo de Diagnostico por Imagem (FIDI), Sao Paulo, SP (Brazil); Medeiros, Regina B., E-mail: regina.bitelli@fidi.org.br [Instituto de Pesquisa e Ensino em Medicina Diagnostica e Terapeutica (IPmed), Sao Paulo, SP (Brazil)

2013-10-01

The FIDI company providing service to local health care system is responsible for managing part of the services diagnostic imaging of Sao Paulo in the South and Southeast ( 60 % ), Eastern ( 20 % ) and Midwest (20 %), Brazil. The generation of images in the municipal net is performed in conventional manner. Since 2009 works a maintenance associated with the verification of the performance of radiological equipment (annual) and processing (monthly) one. In 2008, on the occasion of the agreement between the city hall and FIDI, conditions were evaluated for radiological protection in 52 care units of the municipality. Were carried out verification tests of performance in conventional equipment, mammographic and tomographic equipment, in 138 and 71 analog processors, according to current legislation. In 2008 , 33 % of the devices had technical problems that prevented its operation. Currently only 3.4 % of the 91 are in radiological equipment maintenance. In 2008 the majority of radiological equipment had more than 10 years of manufacturing, while today fixed equipment have been replaced by new ones and therefore the use of mammography and generally have 2 to 3 years of manufacture . Currently the 31 processors are operative in 2008, 28 % were out of order. The replacement of most of the equipment associated with program quality and preventive/corrective maintenance has kept the service in accordance with the law. (author)

Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects

Directory of Open Access Journals (Sweden)

Benjamin Usadi

2016-08-01

Full Text Available Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL in human T-cell lymphotropic virus (HTLV infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-cell lymphotropic virus type 1 (HTLV-1, 45 human T-cell lymphotropic virus type 2 (HTLV-2, and 45 seronegative subjects was selected from the larger HTLV Outcomes Study (HOST cohort, matched on age, sex and race/ethnicity. Telomere-to-single-copy gene (T/S ratio (a measure of TL and HTLV-1 and HTLV-2 proviral loads were measured in peripheral blood mononuclear cells (PBMCs using quantitative PCR (qPCR. Vibration sensation measured by tuning fork during neurologic examinations performed as part of the HOST study allowed for an assessment of peripheral neuropathy. TL was compared between groups using t-tests, linear and logistic regression. Mean T/S ratio was 1.02 ± 0.16 in HTLV-1, 1.03 ± 0.17 in HTLV-2 and 0.99 ± 0.18 in HTLV seronegative subjects (p = 0.322. TL was not associated with HTLV-1 or -2 proviral load. Shorter TL was significantly associated with impaired vibration sense in the HTLV-2 positive group only. Overall, we found no evidence that telomere length was affected by chronic HTLV-1 and HTLV-2 infection. That TL was only associated with peripheral neuropathy in the HTLV-2-positive group is intriguing, but should be interpreted cautiously. Studies with larger sample size and telomere length measurement in lymphocyte subsets may clarify the relationship between TL and HTLV-infection.

Rehabilitation of Sao Sebastiao-Cubatao oil pipeline: integrated planning and action - key for project success

Energy Technology Data Exchange (ETDEWEB)

Serodio, Conrado J.M. [GDK S.A., Salvador, BA (Brazil)

2009-12-19

The execution of the OSBAT 24{sup o}il pipeline rehabilitation project, comprising the substitution of a 30 km section of the 37 years old pipeline has become a real benchmark in the history of this kind of job. The pipeline is inserted in one of the most sensitive environmental areas of the Sao Paulo State - the last Environmental Protection Area of the Mata Atlantica . The growth of human presence in its surroundings during the last three decades, has caused the right-of-way to be totally confined by luxury housing developments, streets, highways and resorts, as well as by the local communities and their activities, schools, and commerce. The pipeline runs through the Serra do Mar unstable mountain range slopes, with sequences of very steep hills and ravines followed by swamps and rivers. The success of such a challenging project - assembling the new line in a narrow ROW with all its restrictions, where the old line was still in operation, and complying with the tight work schedule required by PETROBRAS, was only possible due to a carefully managed combination of: accurate planning, best engineering methods and equipment and experienced workforce, deeply integrated in a massive effort towards safety, environmental care and social responsibility. (author)

Study of geologic and geomorphologic profile of specific regions of Sao Paulo state for preliminary analyses of disposal of low activity radioactive waste

International Nuclear Information System (INIS)

Pigatti, Cristiane Mayer; Madi Filho, Tufic

2007-01-01

Sao Paulo State stays in the most developed region of the South American subcontinent and possesses a clinical hospital infrastructure that satisfies the demand of one of the biggest urban concentrations of the word. The hospitals, clinics, research institutes and centers of the state carry out therapy and diagnosis annually using radiopharmaceuticals, where significant volumes of radionuclide are used. From 1995 to 2001 for example, the demand of technetium generators grew from 5657 to 11300 units. This activity produces diverse types of waste that are classified according to the -Comissao Nacional de Energia Nuclear (CNEN) - safety standards, with procedures recommended for its package, provisory storage, transport and definitive storage. Due to the diversification of applications and of the used materials, the necessary time of confinement depends on the radioisotopes contained in the waste and the treatment method depends on its physical-chemical characteristics. The common sense today, among the nuclear area researchers, is about the necessity for constructing a surface repository for the waste with half-life ranging from 50 to 300 years. This research project will study the possible places, in the State of Sao Paulo, that would be appropriate, according to the CNEN and the IAEA safety standards, for the implantation of a surface repository, capable of answering the increase of low and average intensity waste volumes, foreseen in the Sao Paulo industrial and services expansion. (author)

Human preferences for symmetry: subjective experience, cognitive conflict and cortical brain activity.

Directory of Open Access Journals (Sweden)

David W Evans

Full Text Available This study examines the links between human perceptions, cognitive biases and neural processing of symmetrical stimuli. While preferences for symmetry have largely been examined in the context of disorders such as obsessive-compulsive disorder and autism spectrum disorders, we examine various these phenomena in non-clinical subjects and suggest that such preferences are distributed throughout the typical population as part of our cognitive and neural architecture. In Experiment 1, 82 young adults reported on the frequency of their obsessive-compulsive spectrum behaviors. Subjects also performed an emotional Stroop or variant of an Implicit Association Task (the OC-CIT developed to assess cognitive biases for symmetry. Data not only reveal that subjects evidence a cognitive conflict when asked to match images of positive affect with asymmetrical stimuli, and disgust with symmetry, but also that their slowed reaction times when asked to do so were predicted by reports of OC behavior, particularly checking behavior. In Experiment 2, 26 participants were administered an oddball Event-Related Potential task specifically designed to assess sensitivity to symmetry as well as the OC-CIT. These data revealed that reaction times on the OC-CIT were strongly predicted by frontal electrode sites indicating faster processing of an asymmetrical stimulus (unparallel lines relative to a symmetrical stimulus (parallel lines. The results point to an overall cognitive bias linking disgust with asymmetry and suggest that such cognitive biases are reflected in neural responses to symmetrical/asymmetrical stimuli.

Public policies for energy substitution in bus: the case of city of Sao Paulo; Politicas publicas para a substituicao energetica em onibus: o caso da cidade de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Araujo, Gregorio da Cruz; Zisman, Sandra Francis [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

2012-07-01

Brazil has been on a leading position on fossil fuel substitution in light vehicles. In 2008 and 2009, ethanol contributed with more than 50% of the light vehicle fuel's consumption. A new energetic substitution program was launched in Sao Paulo, and it can be the turning point for the fossil fuel's substitution in the segment of collective transport. This program allows the development of new fuel and engine technologies, and creates opportunities for their deployment on the collective transport market. The economic consequence is a restructuring process that affects the already established markets. There are still big uncertainties about the program's execution, and also about what will be the winning solutions of this, already started, technological race. (author)

Monitoring of water in soil in asparagus irrigated culture in Vale do Sao Francisco, Pernambuco, Brazil; Monitoracao da agua no solo em cultura irrigada de aspargo no Vale do Sao Francisco, Pernambuco

Energy Technology Data Exchange (ETDEWEB)

Antonino, Antonio C. Dantas; Sampaio, Everardo V.S.B.; Dall` Ollio, Attilio; Bernardo, Ana L. Alves [Pernambuco Univ., Recife, PE (Brazil). Dept. de Energia Nuclear; Audry, Pierre [Office de la Recherche Scientifique et Technique d`Outre-Mer (ORSTOM), 75 - Paris (France). Departement Eaux Continentales

1996-08-01

For many years the brazilian government has inactivated the implantation of irrigated areas in the Sao Francisco valley, obtaining high productivity.After the most appropriated areas having been occupied, the irrigation of second choice soils, usually more shallower and more clay is been tried. In one of these areas, the productivity of asparagus is less than the expected. trying to improve productivity by optimization of irrigation, the movement of water on soil and plants is being monitored far the last year and a half. the main results are shown with emphasis on the raining season, the most problematic 5 figs.

Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects.

Science.gov (United States)

Arya, Jaya; Henry, Sebastien; Kalluri, Haripriya; McAllister, Devin V; Pewin, Winston P; Prausnitz, Mark R

2017-06-01

To support translation of microneedle patches from pre-clinical development into clinical trials, this study examined the effect of microneedle patch application on local skin reactions, reliability of use and acceptability to patients. Placebo patches containing dissolving microneedles were administered to fifteen human participants. Microneedle patches were well tolerated in the skin with no pain or swelling and only mild erythema localized to the site of patch administration that resolved fully within seven days. Microneedle patches could be administered by hand without the need of an applicator and delivery efficiencies were similar for investigator-administration and self-administration. Microneedle patch administration was not considered painful and the large majority of subjects were somewhat or fully confident that they self-administered patches correctly. Microneedle patches were overwhelmingly preferred over conventional needle and syringe injection. Altogether, these results demonstrate that dissolving microneedle patches were well tolerated, easily usable and strongly accepted by human subjects, which will facilitate further clinical translation of this technology. Copyright © 2017 Elsevier Ltd. All rights reserved.

Assessment of atmospheric metallic pollution in the metropolitan region of Sao Paulo, Brazil, employing Tillandsia usneoides L. as biomonitor

International Nuclear Information System (INIS)

Figueiredo, A.M.G.; Nogueira, C.A.; Saiki, M.; Milian, F.M.; Domingos, M.

2007-01-01

Tillandsia usneoides L. is an epiphytic bromeliad plant able to absorb water and nutrients directly from the air. For this reason this species was selected to carry out a monitoring study of air pollution in the metropolitan region of Sao Paulo, Brazil. Five consecutive transplantation experiments (8 weeks each) were performed in 10 sites of the city, submitted to different sources of air pollution (industrial, vehicular), using plants collected from an unpolluted area. After exposure, trace metals were analyzed in the plant by instrumental neutron activation analysis. Traffic-related elements such as Zn and Ba presented high concentrations in exposure sites near to heavy traffic avenues (cars, buses and trucks) and may be associated to vehicular sources. For Zn and Co the highest contents were related to industrial zones and can be associated to the presence of anthropogenic emission sources. The rare earth elements, Fe and Rb, probably have soil particles as main source. - This paper is the first work on the use of biomonitors to assess metal pollution in Sao Paulo, Brazil, the biggest city in Latin America

Assessment of atmospheric metallic pollution in the metropolitan region of Sao Paulo, Brazil, employing Tillandsia usneoides L. as biomonitor

Energy Technology Data Exchange (ETDEWEB)

Figueiredo, A.M.G. [Instituto de Pesquisas Energeticas e Nucleares, IPEN-CNEN/SP, Av. Prof. Lineu Prestes 2242, CEP 05508-000, Sao Paulo, SP (Brazil)]. E-mail: anamaria@ipen.br; Nogueira, C.A. [Instituto de Pesquisas Energeticas e Nucleares, IPEN-CNEN/SP, Av. Prof. Lineu Prestes 2242, CEP 05508-000, Sao Paulo, SP (Brazil); Saiki, M. [Instituto de Pesquisas Energeticas e Nucleares, IPEN-CNEN/SP, Av. Prof. Lineu Prestes 2242, CEP 05508-000, Sao Paulo, SP (Brazil); Milian, F.M. [Instituto de Fisica, Universidade de Sao Paulo, Rua do Matao, Travessa R, 187, Cidade Universitaria, CEP 05508-090, Sao Paulo, SP (Brazil); Domingos, M. [Instituto de Botanica, Av. Miguel Stefano No. 3687, CEP 04301-012, Sao Paulo, SP (Brazil)

2007-01-15

Tillandsia usneoides L. is an epiphytic bromeliad plant able to absorb water and nutrients directly from the air. For this reason this species was selected to carry out a monitoring study of air pollution in the metropolitan region of Sao Paulo, Brazil. Five consecutive transplantation experiments (8 weeks each) were performed in 10 sites of the city, submitted to different sources of air pollution (industrial, vehicular), using plants collected from an unpolluted area. After exposure, trace metals were analyzed in the plant by instrumental neutron activation analysis. Traffic-related elements such as Zn and Ba presented high concentrations in exposure sites near to heavy traffic avenues (cars, buses and trucks) and may be associated to vehicular sources. For Zn and Co the highest contents were related to industrial zones and can be associated to the presence of anthropogenic emission sources. The rare earth elements, Fe and Rb, probably have soil particles as main source. - This paper is the first work on the use of biomonitors to assess metal pollution in Sao Paulo, Brazil, the biggest city in Latin America.

Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity.

Science.gov (United States)

Caira, Simonetta; Iannelli, Antonio; Sciarrillo, Rosaria; Picariello, Gianluca; Renzone, Giovanni; Scaloni, Andrea; Addeo, Pietro

2017-12-01

The proteome of liver biopsies from human obese (O) subjects has been compared to those of nonobese (NO) subjects using two-dimensional gel electrophoresis (2-DE). Differentially represented proteins were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS)-based peptide mass fingerprinting (PMF) and nanoflow-liquid chromatography coupled to electrospray-tandem mass spectrometry (nLC-ESI-MS/MS). Overall, 61 gene products common to all of the liver biopsies were identified within 65 spots, among which 25 ones were differently represented between O and NO subjects. In particular, over-representation of short-chain acyl-CoA dehydrogenase, Δ(3,5)-Δ(2,4)dienoyl-CoA isomerase, acetyl-CoA acetyltransferase, glyoxylate reductase/hydroxypyruvate reductase, fructose-biphosphate aldolase B, peroxiredoxin I, protein DJ-1, catalase, α- and β-hemoglobin subunits, 3-mercaptopyruvate S-transferase, calreticulin, aminoacylase 1, phenazine biosynthesis-like domain-containing protein and a form of fatty acid-binding protein, together with downrepresentation of glutamate dehydrogenase, glutathione S-transferase A1, S-adenosylmethionine synthase 1A and a form of apolipoprotein A-I, was associated with the obesity condition. Some of these metabolic enzymes and antioxidant proteins have already been identified as putative diagnostic markers of liver dysfunction in animal models of steatosis or obesity, suggesting additional investigations on their role in these syndromes. Their differential representation in human liver was suggestive of their consideration as obesity human biomarkers and for the development of novel antiobesity drugs.

19 CFR 145.2 - Mail subject to Customs examination.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Mail subject to Customs examination. 145.2 Section 145.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) MAIL IMPORTATIONS General Provisions § 145.2 Mail subject to Customs...

Metab2MeSH: annotating compounds with medical subject headings.

Science.gov (United States)

Sartor, Maureen A; Ade, Alex; Wright, Zach; States, David; Omenn, Gilbert S; Athey, Brian; Karnovsky, Alla

2012-05-15

Progress in high-throughput genomic technologies has led to the development of a variety of resources that link genes to functional information contained in the biomedical literature. However, tools attempting to link small molecules to normal and diseased physiology and published data relevant to biologists and clinical investigators, are still lacking. With metabolomics rapidly emerging as a new omics field, the task of annotating small molecule metabolites becomes highly relevant. Our tool Metab2MeSH uses a statistical approach to reliably and automatically annotate compounds with concepts defined in Medical Subject Headings, and the National Library of Medicine's controlled vocabulary for biomedical concepts. These annotations provide links from compounds to biomedical literature and complement existing resources such as PubChem and the Human Metabolome Database.

Historical accumulation of Trace elements in sediment cores from Tiete river, Sao Paulo, Brazil

Energy Technology Data Exchange (ETDEWEB)

Damatto, S.; Rocha, F.; Baumgardt, D.; Martins, L.; Silva, P.; Favaro, D. [IPEN-CNEN (Brazil)

2014-07-01

Tiete River, with 1100 km of extension, is one of the most economically important river of the state of Sao Paulo, Brazil and throughout its length can be found reservoirs formed by damming its waters. This river is considered one of the most polluted rivers in the world, especially when it passes through the city of Sao Paulo. As a result of pollution observed since the 1950's, a project was established with the aim of evaluating the historic concentration of the trace elements As, Ba, Br, Ca, Ce, Co, Cr, Cs, Eu, Fe, Hf, La, Lu, Na, Nd, Rb, Sb, Sc, Sm, Ta, Tb, Th, U, Yb and Zn (mg.kg{sup -1}), in sediment cores dated by {sup 210}Pb method, sampled is several points of the river, since its source in Salesopolis up the mouth, on the Parana River. This work presents the results obtained by the trace elements above determined in two sediment cores collected in reservoirs in the city of Salesopolis and Pirapora do Bom Jesus. The analytical techniques used for the analysis were instrumental neutron activation analysis and gross beta measurement, respectively. The results obtained for the elements Br, Ce, Cr, Cs, Eu, Nd, Sb, Sm, Th and U are higher than the values of Upper Continental Crust and the sedimentation rate obtained for the reservoir in Salesopolis, 1.53 cm.y{sup -1}, suggest silting processes. The enrichment factor and the geo-accumulation index were used to assess the presence of anthropogenic sources of pollution. Document available in abstract form only. (authors)

Assessment of metal, trace and rare earth element concentrations in a sedimentary profile from Ponte Nova reservoir, Sao Paulo state, Brazil, by NAA

Energy Technology Data Exchange (ETDEWEB)

Rocha, Flavio R.; Bordon, Isabella C.C.L.; Silva, Paulo S.C.; Favaro, Deborah I.T., E-mail: flavio@baquara.com, E-mail: defavaro@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Silva, Sharlleny A.; Franklin, Robson L.; Ferreira, Francisco J., E-mail: shasilva@sp.gov.br, E-mail: rfranklin@sp.gov.br [Companhia Ambiental do Estado de Sao Paulo (ELAI/CETESB), SP (Brazil). Setor de Quimica Inorganica

2015-07-01

Ponte Nova reservoir, located in the upper basin of the Tiete River in the southern region of Sao Paulo State, covers an area of 25.7 km{sup 2} and drains an area of 320 km{sup 2}. It was built in 1972 to control the rivers flow in the Metropolitan Region of Sao Paulo (MRSP) and water supply. A 30 cm sediment core was collected in the dam in August 2014, sliced at every 2.5 cm. Instrumental neutron activation analysis (INAA) was applied to the sediment samples to determine some major (Fe, K and Na), trace (As, Ba, Br, Co, Cr, Cs, Hf, Rb, Sb, Sc, Ta, Tb, Th, U and Zn) and rare earth (Ce, Eu, La, Lu, Nd, Sm, Tb and Yb) elements. The enrichment factor (EF) and Igeo were applied to the results by using NASC (North American Shale Composite) as reference values for sediment contamination index assessment. An EF>1.5 was obtained for As, Hf, Rb, Ta, Th, U, and rare earths Ce, Eu, La, Nd and Sm when NASC values were used, but only for Br, when the last layer concentration values were used as reference values. Similar results were obtained for the Igeo index. For semi-metal As and metals Cr and Zn concentration values were compared to oriented values from Environmental Canada (TEL and PEL) only Cr exceeded TEL value in some slices of the profile. These results may indicate that there is no anthropogenic contribution for the elements analyzed in this reservoir. Multivariate statistical analysis was applied to the results. (author)

Assessment of metal, trace and rare earth element concentrations in a sedimentary profile from Ponte Nova reservoir, Sao Paulo state, Brazil, by NAA

International Nuclear Information System (INIS)

Rocha, Flavio R.; Bordon, Isabella C.C.L.; Silva, Paulo S.C.; Favaro, Deborah I.T.; Silva, Sharlleny A.; Franklin, Robson L.; Ferreira, Francisco J.

2015-01-01

Ponte Nova reservoir, located in the upper basin of the Tiete River in the southern region of Sao Paulo State, covers an area of 25.7 km 2 and drains an area of 320 km 2 . It was built in 1972 to control the rivers flow in the Metropolitan Region of Sao Paulo (MRSP) and water supply. A 30 cm sediment core was collected in the dam in August 2014, sliced at every 2.5 cm. Instrumental neutron activation analysis (INAA) was applied to the sediment samples to determine some major (Fe, K and Na), trace (As, Ba, Br, Co, Cr, Cs, Hf, Rb, Sb, Sc, Ta, Tb, Th, U and Zn) and rare earth (Ce, Eu, La, Lu, Nd, Sm, Tb and Yb) elements. The enrichment factor (EF) and Igeo were applied to the results by using NASC (North American Shale Composite) as reference values for sediment contamination index assessment. An EF>1.5 was obtained for As, Hf, Rb, Ta, Th, U, and rare earths Ce, Eu, La, Nd and Sm when NASC values were used, but only for Br, when the last layer concentration values were used as reference values. Similar results were obtained for the Igeo index. For semi-metal As and metals Cr and Zn concentration values were compared to oriented values from Environmental Canada (TEL and PEL) only Cr exceeded TEL value in some slices of the profile. These results may indicate that there is no anthropogenic contribution for the elements analyzed in this reservoir. Multivariate statistical analysis was applied to the results. (author)

Sanitary surveillance of ionizing radiations use in health services in Sao Paulo State, Brazil; O controle sanitario do uso das radiacoes ionizantes em servicos de saude no Estado de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Aldred, Martha Aurelia; Eduardo, Maria Bernardete de Paula; Goncalves Junior, Nelson [Secretaria de Estado da Saude de Sao Paulo, SP (Brazil). Centro de Vigilancia Sanitaria

1997-12-31

An evaluation of the Sanitarian Surveillance actions developed at Sao Paulo State, Brazil, concerning the control of ionizing radiation is presented. Aspects such as technical standards, inspection forms, assessment and quality assurance programs, in the fields of medical and dental radiology, radiotherapy and nuclear medicine are discussed. A program is also introduced for sample monitoring of these instruments. A set of protocol with criteria to be used in quality assurance programs, including equipment and procedures is presented. Participation of several societies of specialists and consumer defense organizations in the elaboration of technical regulations has contributed to concrete adoption by health care services 19 refs.

Environmental impact from pollutant action in the Billings Reservoir in Sao Paulo metropolitan area - Brazil; Impacto ambiental decorrente da acao de poluentes no Reservatorio Billings na area metropolitana de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Fujita, S; Braghin, P L [Eletricidade de Sao Paulo, SP (Brazil)

1990-12-31

The ELETROPAULO Electricity from Sao Paulo S/A covers 74 municipal district of the State with electric power, signifying 26% of the energy consumed in Brazil. This paper presents problems with the aquatic plants proliferation and the methods used for their control in the ELETROPAULO hydraulic system, compound by generators plants, channels and reservoirs. The main consequences of their evolution and the advantage and disadvantage of the used methods are mentioned. These plant proliferation cause damages for the neighbour population, with some social and sanitary re flexion, and for the Company operation. Considerations for an improvement of the control methods are also cited. (C.G.C.). 1 fig.

Preliminary analysis on the disposal of high-level radioactive wastes in geological formations of Sao Paulo state, Brazil

International Nuclear Information System (INIS)

Mattos, Luis Antonio Terribile de

1981-01-01

Several studies show that deep geological formations are the most promising solution - technical and economical - for the safe disposal of the high-level radioactive wastes produced by the nuclear industry. In order to obtain the necessary information to assess on the use of geological sites in Brazil - for the disposal of high-level radioactive waste generated by the brazilian nuclear industry - a careful survey on the basalt and granite rocks of Sao Paulo State was made. The data obtained were evaluated according to guidelines established by the International Atomic Energy Agency. The favourable and unfavourable characteristics of the basalts, granites and their respective occurrence areas in the Sao Paulo state territory - as potential waste disposal sites - were analysed. This preliminary and regional characterization is not a conclusive study whether these two rocks types are definitively the most suitable geological formations for use as nuclear waste repository or not. It is the subsidy for a more detailed analysis. Other factors such as social, political and economical aspects, ecological effects, engineering geology, heat generation rate of the waste, type of radiation emitted and corrosive nature of the waste must also be taken into account. (author)

Biomonitoring in coastal regions of Sao Paulo state using transplanted mussels (Perna perna) and instrumental neutron activation analysis

Energy Technology Data Exchange (ETDEWEB)

Catharino, M.G.M.; Vasconcellos, M.B.A.; Moreira, E.G. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mails: mgcatharino@uol.com.br; mbvascon@ipen.br; emoreira@ipen.br; Sousa, E.C.P.M.; Pereira, C.D.S. [Universidade de Sao Paulo (USP), SP (Brazil). Instituto Oceanografico]. E-mails: edvinett@usp.br; camilo@unisanta.br

2007-07-01

In Brazil, due to the extension of the coast and to innumerous pollution problems encountered in several regions, it is necessary the continuous monitoring of many environmental compartments, such as water, soils, sediments and biomonitors in order to assess their environmental quality. Trace elements present in sea water and in marine sediments may accumulate in many invertebrate marine species as bivalve mollusks such as oysters and mussels. These mollusks are able to accumulate pollution, in a sedentary way, remaining alive. Their utility as biomonitor organisms enables the estimation of trace element availability to biomass from different areas. The aim of this study is to give a contribution to the biomonitoring of trace and minor elements such as As, Ca, Co, Cr, Fe, Na, Se and Zn in some regions of the coast of the State of Sao Paulo: Cocanha Beach, Sao Sebastiao and Ilhabela by using the Perna perna mussel, by means of transplanting these organisms from a clean cultivation site (active biomonitoring). Mussels were transplanted to these contaminated areas for different periods of time and elements were determined by Instrumental Neutron Activation Analysis, INAA. Except for Na, the results showed element accumulation for the transplanted mussels. (author)

Biomonitoring in coastal regions of Sao Paulo state using transplanted mussels (Perna perna) and instrumental neutron activation analysis

International Nuclear Information System (INIS)

Catharino, M.G.M.; Vasconcellos, M.B.A.; Moreira, E.G.; Sousa, E.C.P.M.; Pereira, C.D.S.

2007-01-01

In Brazil, due to the extension of the coast and to innumerous pollution problems encountered in several regions, it is necessary the continuous monitoring of many environmental compartments, such as water, soils, sediments and biomonitors in order to assess their environmental quality. Trace elements present in sea water and in marine sediments may accumulate in many invertebrate marine species as bivalve mollusks such as oysters and mussels. These mollusks are able to accumulate pollution, in a sedentary way, remaining alive. Their utility as biomonitor organisms enables the estimation of trace element availability to biomass from different areas. The aim of this study is to give a contribution to the biomonitoring of trace and minor elements such as As, Ca, Co, Cr, Fe, Na, Se and Zn in some regions of the coast of the State of Sao Paulo: Cocanha Beach, Sao Sebastiao and Ilhabela by using the Perna perna mussel, by means of transplanting these organisms from a clean cultivation site (active biomonitoring). Mussels were transplanted to these contaminated areas for different periods of time and elements were determined by Instrumental Neutron Activation Analysis, INAA. Except for Na, the results showed element accumulation for the transplanted mussels. (author)

Contrast media effect on interleukin-2 levels in human plasma in vitro

International Nuclear Information System (INIS)

Napolov, Yu.K.; Borsukova, N.M.; Shimanovskij, N.L.

1992-01-01

As shown in the study of bilignost, iodamide and triombrast action on interleukin-2 (IL-2) level in human plasma in vitro, these contrast media (2.5x10 -2 -2.5x10 -4 M) elevate IL-2 content in blood plasma of sensitive to contrast media subjects in dose-dependent manner

Relationship between eye dominance and pattern electroretinograms in normal human subjects.

Science.gov (United States)

Kamis, Umit; Gunduz, Kemal; Okudan, Nilsel; Gokbel, Hakki; Bodur, Sait; Tan, Uner

2005-02-01

The authors conducted a study in 100 non-smoker healthy normal human subjects to find a relationship between eye dominance and macular function as tested by using transient stimulus and electroretinography. Eye preference procedure was carried out using two reference points and pattern electroretinograms (PERGs) were recorded using black and white checks, each check subtending 23'. Trace averager was retriggered every 300 milliseconds (ms) with data collection time of 150 ms. The difference in PERG P50 amplitudes between right and left eyes was analyzed using Student's t test. There was no significant difference in PERG P50 amplitudes between the right and left eye dominant subjects as well as no significant differences between the right and left eyes in right eye dominants and left eye dominants, but in the left-eye dominant group the left eye PERG P50 amplitudes were significantly higher in females than males. Although pattern-reversal visual evoked potentials of healthy subjects provide electrophysiological evidence of lateralization in the nervous system, sensory eye dominance seems to have no correlation with macular function.

Sanitary surveillance of ionizing radiations use in health services in Sao Paulo State, Brazil

International Nuclear Information System (INIS)

Aldred, Martha Aurelia; Eduardo, Maria Bernardete de Paula; Goncalves Junior, Nelson

1997-01-01

An evaluation of the Sanitarian Surveillance actions developed at Sao Paulo State, Brazil, concerning the control of ionizing radiation is presented. Aspects such as technical standards, inspection forms, assessment and quality assurance programs, in the fields of medical and dental radiology, radiotherapy and nuclear medicine are discussed. A program is also introduced for sample monitoring of these instruments. A set of protocol with criteria to be used in quality assurance programs, including equipment and procedures is presented. Participation of several societies of specialists and consumer defense organizations in the elaboration of technical regulations has contributed to concrete adoption by health care services

Receptor modelling of atmospheric aerosols in the urban area of Sao Paulo. Appendix 5

International Nuclear Information System (INIS)

Artaxo, P.; Castro, W.E. Jr. de; Freitas, M. de; Longo, K.M.

1995-01-01

The urban area of Sao Paulo has shown high concentrations of inhalable particulate matter, indicating air pollution problems. Back carbon concentration represents 26.1±9.7% of the fine mode aerosol mass, indicating the importance of diesel emission. Factor analysis was able to separate four factors, with a transportation-related component, a resuspended soil dust and an oil combustion component. A fourth factor mainly with Br was also observed. An independent multivariate analysis technique using Cluster analysis showed very similar elemental relationships. The results indicate that the transportation sector gives an important contribution to fine mode aerosol concentration

Receptor modelling of atmospheric aerosols in the urban area of Sao Paulo. Appendix 5

Energy Technology Data Exchange (ETDEWEB)

Artaxo, P; Castro, W.E. Jr. de; Freitas, M de; Longo, K M [Grupo de Estudos de Poluicao do Ar, Departamento de Fisica Aplicada, Instituto de Fisica, Universidade de Sao Paulo, USP, Sao Paulo, SP (Brazil)

1995-07-01

The urban area of Sao Paulo has shown high concentrations of inhalable particulate matter, indicating air pollution problems. Back carbon concentration represents 26.1{+-}9.7% of the fine mode aerosol mass, indicating the importance of diesel emission. Factor analysis was able to separate four factors, with a transportation-related component, a resuspended soil dust and an oil combustion component. A fourth factor mainly with Br was also observed. An independent multivariate analysis technique using Cluster analysis showed very similar elemental relationships. The results indicate that the transportation sector gives an important contribution to fine mode aerosol concentration.

Faciologic characterization of coal beds in the Cerquilho region, state of Sao Paulo, Brazil

International Nuclear Information System (INIS)

Nagalli, J.T.; Consoni, J.O.C.

1984-01-01

Since 1981, NUCLEBRAS, researches the Tubarao group in the state of Sao Paulo, in order to evaluate the uraniferous potential of carbonaceous sediments in the Parana Basin. This work discusses geologic information concerning the Cerquilho area, where, the faciologic and structural characterization of the coal beds (or seams) were analyzed, and the main targets for uranium concentration were identified. Such study was performed through detailed field observations, imagery and aerial photograph interpretation as well as well logging analysis. Results suggested that the uraniferous anomalies are controlled by fluvial channels cutting the coal beds, with periglacial influence. (Author) [pt

Faktor Ibu dan Faktor Bayi Dengan Respon Fisiologi (Saturasi O2 Pada Bayi Prematur Yang Dilakukan Developmental Care

Directory of Open Access Journals (Sweden)

Gustop Amatiria

2017-11-01

Full Text Available Prematurity is the leading cause of death in children under the age of 5 years in the world and in Indonesia in 2012 recorded around 675,700 or 15.5 per 100 births. Premature infant mortality is largely due to maladaptive environmental response extrauterine causing the baby's environmental stress causing problems in the circulation, oxygenation and metabolic that can interfere with the growth and development neurophysiologic of a baby so that in premature infants should be done Developmental Care Efforts (Light and Sound Setting. Differences Maternal and infant factors may affect the optimization of the application of developmental care by regulating light and sound received by infants in an effort to optimize the growth of infant development in the perinatology space to achieve a normal physiological response in which one indicator is the adequacy of O2 indicated by oxygen Saturation value (Sa O2. This study aimed to determine the relationship between mother and infant factors after Development Care (light and sound settings received with physiological response (Sa O2, premature babies. The research design used was analytical with cross sectional approach. The samples used by 45 infants were selected by consecutive sampling technique. The analysis used a correlation test to determine the strength of the relationship (r and 95% confidence intervals. The results showed that there was a significant relationship between economic status and SaO2 (r = -0.509; p value = 0.016, but no significant relationship between maternal age and SaO2 (r = -0.005; p-value = 0.982; history of diseases during pregnancy with SaO2 (r = 0.121; p-value = 0,591; gestational age with SaO2 (r = -0.004; p-value = 0.985; neuromuscular maturity with SaO2 (r = -0.64; p-value = 0.777; weight with SaO2 (r = -0.189; p-value = 0.399; length of body with SaO2 (r = -0.028; p-value = 0.901.   Keywords: Mother, Premature infant, Developmental care

Profile of the subjects with soft tissue injuries attended at an occupational health service and the RSI

Directory of Open Access Journals (Sweden)

Camila de Freitas

2015-07-01

Full Text Available Aim: To investigate the profile of subjects with soft tissue injuries attended at the Reference Center of Occupational Health – CEREST in the municipality of Santos, Sao Paulo state, in 2010, and the social insurance benefits granted.Materials and Methods: Analysis of medical records of the subjects assisted at CEREST in 2010, surveying data on gender, age, occupation, clinical diagnostics, clinical complaints, retirement, etc. The clinical diagnostics were categorized according to the International Classification of Diseases - ICD-10, subjects with soft tissue injuries were selected, and the diagnostics related to mental health disorders were registered. Data were recorded in Microsoft Excel spreadsheet and analyzed using statistical software R Development Core Team.Results: Of the 206 medical records analyzed, 18.0% (n=37 showed soft tissue injuries, 81.1% were female and 18.9% were male, and the subjects’ mean age was 43.24 years (SD=8.76. Subjects between 31 and 50 years old (70.2% were the most affected. The most affected occupations were cleaners, general service workers, and bank clerks. The most prevalent clinical diagnoses were synovitis and tenosynovitis, shoulder bursitis, and rotator cuff syndrome, with 62.2% of the subjects presenting more than one clinical diagnosis. 13.5% of the subjects also presented mental disorders. Association between retirement from work and the presence of soft tissue injury was observed (p=0.032. Only 13.5% of the diagnoses had some association with the work conditions.Conclusions: The general profile of the workers with soft tissue injuries was obtained: prevalence in women, diseases manifested in productive age, difficulty of association with work conditions, need for interdisciplinary interventions.

Canadian governance of health research involving human subjects: is anybody minding the store?

Science.gov (United States)

McDonald, M

2001-01-01

From an ethical perspective, good governance involves the translation of collective moral intentions into effective and accountable institutional actions. With respect to the use of human subjects in Canadian health research, I contend that there have been many good intentions but very little in the way of appropriate governance arrangements. Hence, the question, "who minds the store?" is especially acute with respect to the protection of vulnerable individuals and groups that are typically recruited as subjects for health research in Canada. Beyond diagnosing failures in governance and their causes, I offer suggestions for significant reforms, including evidence-based ethics assessment, independent oversight, and greater participation of research subjects in governance. I will close with some more general reflections on ethics, law, and governance.

The Role of Intuition in Risk/Benefit Decision-Making in Human Subjects Research.

Science.gov (United States)

Resnik, David B

2017-01-01

One of the key principles of ethical research involving human subjects is that the risks of research to should be acceptable in relation to expected benefits. Institutional review board (IRB) members often rely on intuition to make risk/benefit decisions concerning proposed human studies. Some have objected to using intuition to make these decisions because intuition is unreliable and biased and lacks transparency. In this article, I examine the role of intuition in IRB risk/benefit decision-making and argue that there are practical and philosophical limits to our ability to reduce our reliance on intuition in this process. The fact that IRB risk/benefit decision-making involves intuition need not imply that it is hopelessly subjective or biased, however, since there are strategies that IRBs can employ to improve their decisions, such as using empirical data to estimate the probability of potential harms and benefits, developing classification systems to guide the evaluation of harms and benefits, and engaging in moral reasoning concerning the acceptability of risks.

Multitaper spectral analysis of cosmic rays Sao Martinho da Serra's muon telescope and Newark's neutron monitor data

Energy Technology Data Exchange (ETDEWEB)

Silva, Marlos Rockenbach da; Alarcon, Walter Demetrio Gonzalez; Echer, Ezequiel; Lago, Alisson dal; Lucas, Aline de [National Institute for Space Research - INPE-MCT, Sao Jose dos Campos, SP (Brazil); Vieira, Luis Eduardo Antunes; Guarnieri, Fernando Luis [Universidade do Vale do Paraiba - UNIVAP, Sao Jose dos Campos, SP (Brazil); Schuch, Nelson Jorge [Southern Regional Space Research Center - CRSPE/INPE-MCT, Santa Maria, RS (Brazil); Munakata, Kazuoki, E-mail: marlos@dge.inpe.br, E-mail: gonzalez@dge.inpe.br, E-mail: eecher@dge.inpe.br, E-mail: dallago@dge.inpe.br, E-mail: delucas@dge.inpe.br, E-mail: levieira@univap.br, E-mail: guarnieri@univap.br, E-mail: njschuch@lacesm.ufsm.br, E-mail: kmuna00@gipac.shinshu-u.ac.jp [Physics Department, Shinshu University, Matsumoto (Japan)

2007-07-01

In this work we present an analysis on the correction efficiency of atmospheric effects on cosmic ray Sao Martinho da Serra's muon telescope and Newark's neutron monitor data. We use a Multitaper spectral analysis of cosmic rays time series to show the main periodicities present in the corrected and uncorrected data for the atmospheric effects. This kind of correction is very important when intends to study cosmic rays variations of extra-terrestrial origin. (author)

Values and attitudes of entrepreneurs in Sao Tome and Principe: A study based on Q Methodology

OpenAIRE

Gil, Fabiola; Dentinho, Tomaz

2010-01-01

Sao Tome e Principe is a small insular country located in the Gulf of Guinea, populated by 160000 persons, living in 1000 square kilometers of a rainforest environment. The GDP pc is 1200 US$ per year, 50% of the economy is based in auto-consumption and the main engine of the remaining economic system is the external public debt, rents from promising oil, and donations (50%), complemented by tourism, cacao exports, private transferences, and other exports. To understand the role of local entr...

Public policies for energy substitution in bus: the case of city of Sao Paulo; Politicas publicas para a substituicao energetica em onibus: o caso da cidade de Sao Paulo

Energy Technology Data Exchange (ETDEWEB)

Araujo, Gregorio da Cruz; Zisman, Sandra Francis [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

2012-07-01

Brazil has been on a leading position on fossil fuel substitution in light vehicles. In 2008 and 2009, ethanol contributed with more than 50% of the light vehicle fuel's consumption. A new energetic substitution program was launched in Sao Paulo, and it can be the turning point for the fossil fuel's substitution in the segment of collective transport. This program allows the development of new fuel and engine technologies, and creates opportunities for their deployment on the collective transport market. The economic consequence is a restructuring process that affects the already established markets. There are still big uncertainties about the program's execution, and also about what will be the winning solutions of this, already started, technological race. (author)

Rock Rb-Sr ages from Bananal region - Sao Paulo State, Brazil

International Nuclear Information System (INIS)

Dias Neto, C.M.; Tassinari, C.G.C.; Silva, M.E.

1996-01-01

New Rb-Sr whole rock isochron ages have been determined for the main lithological units that occur in Sao Paulo and Rio de Janeiro States. These rocks belong to Serra do Mar domain. The purpose of this work is to characterize the sequence of the geological events as well as the possible relationship between the different rocks. The geochronological data suggest that the paragneisses and the basement rocks, represented by ortho gneisses nuclei, were generated under amphibolite conditions around 700 Ma. At the same time the leucogranites were generated by partial melting processes and injected into both gneiss types. Tarditectonic granitic magmatic activities took place within ductile shear zones. One of the granites, the Getulandia granite, yielded an age of 514 Ma, falling in the range of the late Brasiliano Cycle which extended into the Middle Cambrian. (author). 9 figs., 1 tab

The Rio de Janeiro - Sao Paulo pipeline: the interests onset in the emptiness of the energy and regional development federal politics; Oleoduto Rio de Janeiro-Sao Paulo: embate de interesses no vazio da politica federal de energia e de desenvolvimento regional

Energy Technology Data Exchange (ETDEWEB)

Alveal, Carmen

2007-07-01

The PETROBRAS project in constructing a pipeline between the Rio de Janeiro and Sao Paulo states originated a dispute of strategic interests between the PETROBRAS and the Rio de Janeiro state. However, the relevant dimension in this dispute is the absence of a Brazilian politics for the development of refining as an important thruster of regional development; this theme deserve to be inserted in the Brazilian energy politic agenda.

Annual report 2006 - CPFL Energy - Light and Power Company from Sao Paulo, SP; Relatorio anual 2006 - CPFL Energia - Companhia Paulista de Forca e Luz

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

This document reports the activities during 2006 of the Sao Paulo Light and Power (CPFL) as follows: society evolution, corporative and ethic management; economic and financial performance; operational performance, sustainability management and corporative responsibility.

Art collection preservation: gamma radiation application for decontaminating objects in the Instituto de Estudos Brasileiros from Universidade de Sao Paulo (USP), SP, Brazil

International Nuclear Information System (INIS)

Rela, Paulo Roberto; Gomes, Fatima Faria; Thome, Lucia Elena; Kodama, Yasko

2008-01-01

The Instituto de Estudos Brasileiros (IEB) from the University of Sao Paulo received the charge from Sao Paulo's Federal Justice to take care of part of the collection from Banco Santos that was severely attacked by insects and micro-organisms (moulds) when stored in a warehouse that was flooded by intense rainfall. A chemical treatment to eliminate the biodeterioration agents was tried but it was not effective. As the heap has a large amount of Xylograph wood dye, printings and manuscripts from cordel literature an urgent way to treat was searched and after the study and previous experience on wood irradiation process it was decided to submit promptly the heap to gamma irradiation. After the treatment the art pieces were restored by IEB staff and now is being part of IEB collection and available for the scientific research community (author)

Shield calculation of project for instrument calibration integrated laboratory of IPEN-Sao Paulo, Brazil; Calculo das blindagens do projeto de um laboratorio integrado de calibracao de instrumentos no IPEN - Sao Paulo, Brasil

Energy Technology Data Exchange (ETDEWEB)

Barros, Gustavo A.S.J.; Caldas, Linda V.E., E-mail: gustavaobarros@gmail.co, E-mail: lcaldas@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2009-07-01

This work performed the shield calculation of the future rooms walls of the five X-ray equipment of the Instrument Calibration Laboratory of the IPEN, Sao Paulo, Brazil, which will be constructed in project of laboratory enlargement. The obtained results by application of a calculation methodology from an international regulation have shown that the largest thickness of shielding (25.7 cm of concrete or 7.1 mm of lead) will be of the wall which will receive the primary beam of the equipment with a 320 kV voltage. The cost/benefit analysis indicated the concrete as the best material option for the shielding

43 CFR 2.47 - Records subject to Privacy Act.

Science.gov (United States)

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Records subject to Privacy Act. 2.47 Section 2.47 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.47 Records subject to Privacy Act. The Privacy Act applies to all...

Viability evaluation of the reading system by CCD for application at the Fricke xylenol gel dosimetry developed by IPEN-Sao Paulo, Brazil

International Nuclear Information System (INIS)

Mangueira, Thyago Fressatti; Dias, Daniel Menezes; Campos, Leticia Lucente

2009-01-01

The use of chambers with coupled charge devices - CCD, is already used by research centres for the dose evaluation applying the Fricke xylenol gel dosemeter. This work evaluates the application of this optical reading technique for the FXG developed at the IPEN, Sao Paulo, Brazil

Distribution of 226Ra, 232Th and 40K in soils and sugar cane crops at Corumbatai river basin, Sao Paulo State, Brazil

International Nuclear Information System (INIS)

Tomazini da Conceicao, Fabiano; Bonotto, Daniel Marcos; Jimenez-Rueda, Jairo Roberto; Frutuoso Roveda, Jose Arnaldo

2009-01-01

The common use of phosphate fertilizers NPK and amendments in sugar cane crops in Brazilian agriculture may increase the 226 Ra, 232 Th and 40 K activity concentrations in soils and their availability for plants and human food chain. Thus, the main aim of this study was to evaluate the distribution of 226 Ra, 232 Th and 40 K in soils and sugar cane crops in the Corumbatai river basin, Sao Paulo State, Brazil. The gamma spectrometry was utilized to measure the 226 Ra, 232 Th and 40 K activity concentration in all samples. The soil-to-sugar cane transfer factors (TF) were quantified using the ratio between the radionuclide activity concentration in sugar cane and its activity concentration in soil. The results show that, although radionuclides incorporated in phosphate fertilizers and amendments are annually added in the sugar cane crops, if utilized in accordance with the recommended rates, their use does not lead to hazards levels in soils. The soil-to-sugar cane transfer of radionuclides occurred in the following order 40 K> 226 Ra> 232 Th. Therefore, under these conditions, radionuclides intake through consumption of sugar is not hazardous to human health.

K-Ar geochronology of mafic dyke swarms from the meridional part of Sao Francisco craton and implications on tectonic context

International Nuclear Information System (INIS)