The application of bifrontal electrotherapy in patients with a diagnosis of schizophrenia – case series description

Directory of Open Access Journals (Sweden)

Karina Nowakowska

2017-09-01

Full Text Available Electrotherapy is considered a very effective and safe therapeutic method. Its most frequently described adverse effect is the impairment of cognitive functions. Currently, the most commonly applied form of electrotherapy are bitemporal procedures and the most frequent and best-studied indication for its application are depressive disorders. A method combining high effectiveness with satisfactory safety is the bifrontal application of the electrodes, although study results are often inconsistent. An issue which should also be noted is the lack of studies comparing the effectiveness of bifrontal and bitemporal procedures in the reduction of positive and negative symptoms of schizophrenia and assessing the safety of these methods in terms of the influence on cognitive functions. The present paper presents a clinical description of four patients with schizophrenia who have undergone electrotherapy procedures performed applying the bifrontal method. The decisive indication for applying the bifrontal procedures were the memory disturbances the persistence of which was reported by the patients during the application of bitemporal procedures. The analysed clinical cases indicate the effectiveness of the bifrontal electrotherapy procedures which was comparable with the effectiveness of bitemporal procedures with the simultaneous better toleration of the former. Improvement was observed in terms of paranoid, catatonic and negative schizophrenia symptoms. At the same time the patients reported subjectively better tolerance of the procedures, as well as improvement in the recalling of facts and events.

Prolifération filamenteuse en boues activées

OpenAIRE

Juzan, L.; Vedrenne, J.

2010-01-01

/ Le développement excessif de bactéries filamenteuses en boues activées peut entrainer des dysfonctionnements biologiques tels qu'un foisonnement et/ou un moussage stable. Quels sont les moyens de prévention, de diagnostic et de traitement actuellement disponibles ?

Exploitation du savoir autochtone afin de créer des emplois pour les ...

International Development Research Centre (IDRC) Digital Library (Canada)

La Commission des Nations unies pour la démarginalisation estime que quatre milliards de personnes ne peuvent pas exercer leurs droits juridiques à cause des coûts, du dysfonctionnement, de la corruption ou de l'abus de pouvoir. Il existe un besoin reconnu en institutions intermédiaires, comme les médias, les partis ...

Le marché central de Kpalimé : implications spatiales et contraintes ...

African Journals Online (AJOL)

Cette forme d'occupation au gré des opportunités provoque un dysfonctionnement du marché et l'empiètement sur les espaces publics, présentant ainsi un enjeu d'aménagement important. Le manque de moyen financier rend incapable la municipalité décentralisée à faire face aux besoins de réhabilitation et de ...

Automatic change detection and quantification of dermatological diseases with an application to psoriasis images

DEFF Research Database (Denmark)

Gomez, David Delgado; Butakoff, C.; Ersbøll, Bjarne Kjær

2007-01-01

Change monitoring in skin lesion analysis has proven to be a useful adjunct in their assessment. This article presents a comparative study of the available change detection techniques applied to change visualization and quantification in bi-temporal psoriasis images. The chosen methods are evalua...

Unilateral brief-pulse electroconvulsive therapy and cognition: Effects of electrode placement, stimulus dosage and time.

LENUS (Irish Health Repository)

Semkovska, Maria

2010-11-23

To clarify advantages of unilateral electrode placement as an optimisation technique for electroconvulsive therapy (ECT) for depression, aims were to meta-analyse unilateral ECT effects on cognitive performance relative to: (1) bitemporal electrode placement, (2) electrical dosage, and (3) time interval between final treatment and cognitive reassessment. Relevant electronic databases were systematically searched through May 2009, using the terms: "electroconvulsive therapy" and ["cogniti∗", "neuropsycholog∗", "memory", "attention", "executive", "spatial", or "intellectual"]. Inclusion criteria were: independent study of depressed patients receiving unilateral or bitemporal brief-pulse ECT; within-subjects design; use of objective cognitive assessments; available mean electrical dosage for unilateral samples. Standardized pre-post ECT weighted effect sizes were computed and pooled within 16 cognitive domains by a mixed-effects model. Thirty-nine studies (1415 patients) were meta-analysed. Up to three days after final treatment, unilateral ECT was associated with significantly smaller decreases in global cognition, delayed verbal memory retrieval, and autobiographical memory, compared to bitemporal ECT. Significant publication bias was found for autobiographical memory, favouring reporting of larger percentage loss. Higher unilateral ECT electrical dosage predicted larger decreases in verbal learning, delayed verbal memory retrieval, visual recognition, and semantic memory retrieval. When retested more than three days after completing ECT, no significant differences remained between the two electrode placements; for unilateral ECT, electrical dosage no longer predicted cognitive performance whereas increasing interval between final treatment and retesting predicted growing improvement in some variables. This interval is a more useful long-term predictor of cognitive function than electrode placement or electrical dosage following unilateral ECT.

Unilateral brief-pulse electroconvulsive therapy and cognition: effects of electrode placement, stimulus dosage and time.

Science.gov (United States)

Semkovska, Maria; Keane, Deborah; Babalola, Oyemi; McLoughlin, Declan M

2011-06-01

To clarify advantages of unilateral electrode placement as an optimisation technique for electroconvulsive therapy (ECT) for depression, aims were to meta-analyse unilateral ECT effects on cognitive performance relative to: (1) bitemporal electrode placement, (2) electrical dosage, and (3) time interval between final treatment and cognitive reassessment. Relevant electronic databases were systematically searched through May 2009, using the terms: "electroconvulsive therapy" and ["cogniti∗", "neuropsycholog∗", "memory", "attention", "executive", "spatial", or "intellectual"]. Inclusion criteria were: independent study of depressed patients receiving unilateral or bitemporal brief-pulse ECT; within-subjects design; use of objective cognitive assessments; available mean electrical dosage for unilateral samples. Standardized pre-post ECT weighted effect sizes were computed and pooled within 16 cognitive domains by a mixed-effects model. Thirty-nine studies (1415 patients) were meta-analysed. Up to three days after final treatment, unilateral ECT was associated with significantly smaller decreases in global cognition, delayed verbal memory retrieval, and autobiographical memory, compared to bitemporal ECT. Significant publication bias was found for autobiographical memory, favouring reporting of larger percentage loss. Higher unilateral ECT electrical dosage predicted larger decreases in verbal learning, delayed verbal memory retrieval, visual recognition, and semantic memory retrieval. When retested more than three days after completing ECT, no significant differences remained between the two electrode placements; for unilateral ECT, electrical dosage no longer predicted cognitive performance whereas increasing interval between final treatment and retesting predicted growing improvement in some variables. This interval is a more useful long-term predictor of cognitive function than electrode placement or electrical dosage following unilateral ECT. Copyright © 2010

Croissance et production de matières de Typha australis (SCHUM ...

African Journals Online (AJOL)

SARAH

28 févr. 2015 ... RESUME. Objectifs : Les plantes invasives entraînent un dysfonctionnement des écosystèmes particulièrement dans les zones humides à vocation agricole comme celle des « Niayes » où le niveau de l'eau fluctue au cours de l'année. La présente étude a pour but d'apprécier la croissance et la production ...

Change detection in quad and dual pol, single- and bi-frequency SAR data

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Conradsen, Knut; Skriver, Henning

2015-01-01

-value are given. In a case study airborne EMISAR C- and L-band SAR images covering agricultural fields and wooded areas near Foulum, Denmark, are used in single- and bi-frequency, bi-temporal change detection with full and dual polarimetry data. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation...

Change Detection in Full and Dual Polarization, Single- and Multifrequency SAR Data

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Conradsen, Knut; Skriver, Henning

2015-01-01

of obtaining a smaller value of the test statistic are given. In a case study, airborne EMISAR C- and L-band SAR images from the spring of 1998 covering agricultural fields and wooded areas near Foulum, Denmark, are used in single- and bifrequency, bitemporal change detection with full and dual polarimetry...

Corrections to “Change Detection in Full and Dual Polarization, Single- and Multi-Frequency SAR Data”

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Conradsen, Knut; Skriver, Henning

2017-01-01

of obtaining a smaller value of the test statistic are given. In a case study airborne EMISAR C- and L-band SAR images from the spring of 1998 covering agricultural fields and wooded areas near Foulum, Denmark, are used in single- and bi-frequency, bi-temporal change detection with full and dual polarimetry...

Prise en charge des RCIU d'origine placentaire avant 32 semaines d'aménorrhée. Enquête nationale sur les pratiques françaises

OpenAIRE

Patte , Charlotte

2013-01-01

Non disponible / Not available; Introduction : Bien qu'étant la première cause de morbidité et de mortalité périnatale, leRetard de Croissance Intra Utérin (RCIU) reste une pathologie obstétricale complexe dans son diagnostic et sa prise en charge. Le RCIU d'origine placentaire est un processus pathologique consistant en une altération de la croissance due à un dysfonctionnement placentaire, avec défaut chronique d'apports au foetus. Il n'existe actuellement pas de possibilité de prise en cha...

Anterograde and Retrograde Amnesia following Bitemporal Infarction

Directory of Open Access Journals (Sweden)

A. Schnider

1994-01-01

Full Text Available A patient suffered very severe anterograde and retrograde amnesia following infarction of both medial temporal lobes (hippocampus and adjacent cortex and the left inferior temporo-occipital area. The temporal stem and the amygdala were intact; these structures do not appear to be critical for new learning in humans. Extension of the left-sided infarct into the inferior temporo-occipital lobe, an area critically involved in visual processing, appears to be responsible for our patient's loss of remote memories.

Extramedullary plasmocytoma of the rhino pharynx associated to intrathoracic mass - a case report

International Nuclear Information System (INIS)

Souza, Andrea Silveira de; Fernandes, Artur da Rocha Correa; Yamashita, Helio Kiitiro

1996-01-01

The authors report a case of a 56-year-old while male, who had occipital headache, libido and visual acuity (bitemporal field) reduction as the clinical picture, with progressive evolution within a four years period. The image diagnosis methods (roentgenologic studies, (MRI) demonstrated extensive mass involving the sella, clivus and sphenoid sinus, and an intrathoracic mass on the right. The final diagnosis was extramedullary plasmocytoma with rhinopharynx origin. (author)

Fibrose hépatique : lien force mécanique et génotoxicité

OpenAIRE

Langouët , Sophie

2014-01-01

En 2012, en France, il y a eu 6.867 nouveaux cas de cancer du foie chez l’homme et 1.586 chez la femme. On soupçonne que les maladies du foie sont associées à un dysfonctionnement sévère des fonctions hépatiques et susceptibles d’entraîner une sensibilité accrue des patients vis-à-vis des contaminants environnementaux. Comment évaluer cette susceptibilité individuelle au cours de maladies chroniques, qui se prolongent dans le temps ? L’objectif du projet Mécagénotox est de caractériser et mod...

Patpong, entre sexe et commerce.

OpenAIRE

Sébastien Roux

2010-01-01

Le tourisme dit « sexuel » est aujourd’hui décrié comme une forme de tourisme international immoral, un dysfonctionnement grave de la mondialisation appelant une réaction politique contre « l’exploitation sexuelle » dont seraient victimes des millions de femmes et d’enfants. Pourtant, derrière l’apparente évidence du « tourisme sexuel » comme expression de sens commun, rares sont les enquêtes qui explicitent la réalité concrète des échanges prostitutionnels. En adoptant une démarche ethnograp...

La possibilité d'un encadrement juridique des lanceurs d'alerte par l'Union européenne

OpenAIRE

Racho, Tania

2016-01-01

Plusieurs raisons peuvent justifier la nécessité d’une réglementation pour protéger les lanceurs d'alerte au niveau de l'Union européenne. Les alertes médiatisées concernent des dysfonctionnements aux dimensions européennes voire internationales comme par exemple avec les affaires révélées par Snowden ou le Luxleaks. La pertinence d'une action de l'Union européenne est évidente et permettrait alors d'accorder une protection minimale identique sur le territoire des 28 États membres. Néanmoins,...

Multivariate Alteration Detection (MAD) and MAF Postprocessing in Multispectral, Bitemporal Image Data: New Approaches to Change Detection Studies

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Conradsen, Knut; Simpson, James J.

1998-01-01

type analyses of simple difference images. Case studies with AHVRR and Landsat MSS data using simple linear stretching and masking of the change images show the usefulness of the new MAD and MAF/MAD change detection schemes. Ground truth observations confirm the detected changes. A simple simulation...

Confrontation visual field testing in routine ophthalmic practice ...

African Journals Online (AJOL)

Results: Two patients had symptoms of headache and visual blurring, galactorrhea and amenorrhea. A right homonymous hemianopia and bitemporal hemianopia respectively were detected on CVF. The 3rd patient complained of visual blurring and bumping into objects following an assault to the head. CVF detected ...

Camera derived vegetation greenness index as proxy for gross primary production in a low Arctic wetland area

DEFF Research Database (Denmark)

Westergaard-Nielsen, Andreas; Lund, Magnus; Hansen, Birger Ulf

2013-01-01

vegetation index (NDVI) product derived from the WorldView-2 satellite. An object-based classification based on a bi-temporal image composite was used to classify the study area into heath, copse, fen, and bedrock. Temporal evolution of vegetation greenness was evaluated and modeled with double sigmoid...... and GPP (R-2 = 0.85, p remote Arctic regions....... (C) 2013 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS) Published by Elsevier B.V. All rights reserved....

Sensitive change detection for remote sensing monitoring of nuclear treaties

DEFF Research Database (Denmark)

Canty, Morton J.; Nielsen, Allan Aasbjerg; Schlittenhardt, Jörg

2005-01-01

change is a commonplace application in remote sensing, the detection of anthropogenic changes associated with nuclear activities, whether declared or clandestine, presents a difficult challenge. It is necessary to discriminate subtle, often weak signals of interest on a background of irrelevant...... in multispectral, bitemporal image data: New approaches to change detection studies, Remote Sens. Environ. 64(1), 1998, pp. 1--19. Nielsen, A. A., Iteratively re-weighted multivariate alteration detection in multi- and hyperspectral data, to be published....

Non disponible / Not available

OpenAIRE

Erika , Nnang Obada

2010-01-01

Non disponible / Not available; La préservation du capital vasculaire est un challenge permanent dans la prise en charge des patients insuffisants rénaux chroniques. Cette démarche doit être systématique, précoce, même en situation d'insuffisance rénale aiguë. La mise en place de cathéters pour l'hémodialyse doit être encadrée. Tout dysfonctionnement réduit l'efficacité d'une séance de dialyse avec une morbidité non négligeable. Dans une étude rétrospective de 62 patients hémodialysés inciden...

Accident vasculaire cérébral hémorragique du tronc cérébral suite à une éclampsie du post partum: à propos d’un cas et revue de la littérature

OpenAIRE

Ennaqui, Khadija; Makayssi, Assia; Boufettal, Houssine; Samouh, Naima

2017-01-01

Les accidents vasculaires cérébraux sont des accidents rares mais graves durant la grossesse et le post-partum, ils sont responsable d'une mortalité et d'une morbidité élevée, la pré éclampsie, l'éclampsie et les accidents vasculaires cérébraux sont significativement liés. Le dysfonctionnement endothélial, l'altération de l'autorégulation cérébrale, et l'hypertension sévère sont, probablement, la cause de nombreux accidents vasculaires cérébraux chez la femme enceinte et durant la période du ...

A method for unsupervised change detection and automatic radiometric normalization in multispectral data

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Canty, Morton John

2011-01-01

Based on canonical correlation analysis the iteratively re-weighted multivariate alteration detection (MAD) method is used to successfully perform unsupervised change detection in bi-temporal Landsat ETM+ images covering an area with villages, woods, agricultural fields and open pit mines in North...... to carry out the analyses is available from the authors' websites....

Object-Based Change Detection in Urban Areas from High Spatial Resolution Images Based on Multiple Features and Ensemble Learning

Directory of Open Access Journals (Sweden)

Xin Wang

2018-02-01

Full Text Available To improve the accuracy of change detection in urban areas using bi-temporal high-resolution remote sensing images, a novel object-based change detection scheme combining multiple features and ensemble learning is proposed in this paper. Image segmentation is conducted to determine the objects in bi-temporal images separately. Subsequently, three kinds of object features, i.e., spectral, shape and texture, are extracted. Using the image differencing process, a difference image is generated and used as the input for nonlinear supervised classifiers, including k-nearest neighbor, support vector machine, extreme learning machine and random forest. Finally, the results of multiple classifiers are integrated using an ensemble rule called weighted voting to generate the final change detection result. Experimental results of two pairs of real high-resolution remote sensing datasets demonstrate that the proposed approach outperforms the traditional methods in terms of overall accuracy and generates change detection maps with a higher number of homogeneous regions in urban areas. Moreover, the influences of segmentation scale and the feature selection strategy on the change detection performance are also analyzed and discussed.

Immunobiological effect of bitemporal exposure of rabbits to microwaves

Energy Technology Data Exchange (ETDEWEB)

Bogolyubov, V.M.; Pershin, S.B.; Frenkel' , I.D.; Sidorov, V.D.; Galenchik, A.I.; Ponomarev, Yu.T.; Bobkova, A.S.; Kuz' min, S.N.; Moshiashvili, I.Ya.; Kozlova, N.N.; Korovkina, E.G.; Agibalov, Yu.V.

1987-01-01

The authors investigate the effects of microwave radiation on the immunological behavior of the thyroid and various hormones of rabbits. Irradiation was carried out on the heads of the animals. They were then divided into four groups depending on the period of exposure. The number of hemolysis-forming cells against sheep red blood cells and the concentration of serum immunoglobulins were determined. Levels of TSH, triiodothyronine, thyroxine, testosterone and prostaglandins in serum or blood plasma were determined by radioimmunoassay and the concentration of total 11-hydroxycorticosteroids in the adrenals and plasma were determined by fluorimetry. Microwave radiation of the temporo-parietal region of the head was found to decrease the number of background hemolysis-forming cells. An increase in glucocorticoid function was recorded. Thyroid function was depressed. The plasma 11-hydroxycorticosteroid level was significantly raised. It is concluded in general that microwave irradiation leads to activation of the hypothalamo-hypophyseo-adrenal system with consequent enhancement of the glucocorticoid function of the adrenal cortex and depression of thyroid function.

Findings of 99mTc-HMPAO Regional Cerebral Blood Flow SPECT in a Case of Herpes Simplex Encephalitis

International Nuclear Information System (INIS)

Ahn, Myeong Im; Lee, Sung Yong; Kim, Jong Woo; Bahk, Yong Whee

1989-01-01

Herpes simplex encephalitis (HSE) is one of the fulminant necrotizing, often fatal sporadic form of the encephalitis caused by herpes simplex type I virus. Characteristically, there is early and almost constant involvement of one or both temporal lobes, although there are common additional areas of involvement. Appropriate early treatment following correct diagnosis by clinical findings, CSF study, EEG and several radiological studies including angiography, radionuclide studies, CT or MRI can reduce its mortality and severity of the sequelae. We report a case of HSE diagnosed by adjuvant study of 99m Tc-HMPAO regional cerebral blood flow SPECT, which showed a marked increase in bitemporal cerebral blood flow in a 24-year-old man.

Retinitis Pigmentosa Sine Pigmento Mimicking a Chiasm Disease.

Science.gov (United States)

Pellegrini, Francesco; Prosdocimo, Giovanni; Romano, Francesco; Interlandi, Emanuela

2017-08-01

A 75-year-old woman presented to her ophthalmologist complaining of visual loss for several years. The ophthalmic examination was remarkable for a bitemporal visual field defect. Magnetic resonance imaging (MRI) scan of the brain was normal without evidence of chiasm compression. Neuro-ophthalmic examination was consistent with a retinal rather than a chiasmal disease. Retinal multimodal imaging helped in the correct diagnosis of retinitis pigmentosa, later confirmed by genetic testing.

Multivariate alteration detection (MAD) in multispectral, bi-temporal image data: A new approach to change detction studies

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Conradsen, Knut

This paper introduces a new orthogonal transformation, the multivariate alteration detection (MAD) transformation, based on an established multivariate statistical technique canonical correlation analysis. The theory for canonical correlation analysis is sketched and a result necessary...... for the definition of the MAD transformation is proven. As opposed to traditional univariate change detection schemes our scheme transforms two sets of multivariate observations (e.g. two multispectral satellite images covering the same geographical area acquired at different points in time) into a difference...... between two linear combinations of the original variables explaining maximal change (i.e. the difference explaining maximal variance) in all variables simultaneously. The MAD transformation is invariant to linear scaling. The MAD transformation can be used iteratively. First, it can be used to detect...

A case of pituitary abscess presenting without a source of infection or prior pituitary pathology

Directory of Open Access Journals (Sweden)

Derick Adams

2016-08-01

Full Text Available Pituitary abscess is a relatively uncommon cause of pituitary hormone deficiencies and/or a suprasellar mass. Risk factors for pituitary abscess include prior surgery, irradiation and/or pathology of the suprasellar region as well as underlying infections. We present the case of a 22-year-old female presenting with a spontaneous pituitary abscess in the absence of risk factors described previously. Her initial presentation included headache, bitemporal hemianopia, polyuria, polydipsia and amenorrhoea. Magnetic resonance imaging (MRI of her pituitary showed a suprasellar mass. As the patient did not have any risk factors for pituitary abscess or symptoms of infection, the diagnosis was not suspected preoperatively. She underwent transsphenoidal resection and purulent material was seen intraoperatively. Culture of the surgical specimen showed two species of alpha hemolytic Streptococcus, Staphylococcus capitis and Prevotella melaninogenica. Urine and blood cultures, dental radiographs and transthoracic echocardiogram failed to show any source of infection that could have caused the pituitary abscess. The patient was treated with 6 weeks of oral metronidazole and intravenous vancomycin. After 6 weeks of transsphenoidal resection and just after completion of antibiotic therapy, her headache and bitemporal hemianopsia resolved. However, nocturia and polydipsia from central diabetes insipidus and amenorrhoea from hypogonadotrophic hypogonadism persisted.

Change detection in bi-temporal data by canonical information analysis

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg; Vestergaard, Jacob Schack

2015-01-01

combinations with the information theoretical measure mutual information (MI). We term this type of analysis canonical information analysis (CIA). MI allows for the actual joint distribution of the variables involved and not just second order statistics. Where CCA is ideal for Gaussian data, CIA facilitates...

Texture alteration detection in bitemporal images of lesions with psoriasis

DEFF Research Database (Denmark)

Maletti, Gabriela Mariel; Ersbøll, Bjarne Kjær

2003-01-01

The objective of this work is to explore the feasibility of quantifying textural change between pairs of segmented patterns without registering them. The Multi-variate Alteration Detection (M.A.D.) Transform is applied to a texture model constructed with the data of segmented psoriasis lesions im...... images. The texture model is Haralick's co-occurrence matrix, which is computed and normalized for each single band with the equalized data of a given lesion. The contribution of each single color band to the textural change is analyzed....

A pediatric case of pituitary macroadenoma presenting with pituitary apoplexy and cranial nerve involvement: case report

OpenAIRE

Özçetin, Mustafa; Karacı, Mehmet; Toroslu, Ertuğ; Edebali, Nurullah

2016-01-01

Pituitary adenomas usually arise from the anterior lobe of the pituitary gland and are manifested with hormonal disorders or mass effect. Mass effect usually occurs in nonfunctional tumors. Pituitary adenomas may be manifested with visual field defects or rarely in the form of total oculomotor palsy. Visual field defect is most frequently in the form of bitemporal hemianopsia and superior temporal defect. Sudden loss of vision, papilledema and ophthalmoplegia may be observed. Pituitary apople...

CT findings of ganglioglioma. Report of 2 cases

Energy Technology Data Exchange (ETDEWEB)

Velasquez, G.R.; Yamazaki, Shingo; Yamaguchi, Takekane (Tokyo Medical and Dental Univ. (Japan). School of Medicine)

1984-06-01

The authors report 2 cases of gangliogliomas of the sellar region, one of which was associated with chromophobe adenoma. Case 1. A 14-year-old female was admitted for a visual disturbance. Neurological examination showed bitemporal hemianopsia and secondary optic atrophy. CT scan showed an isodense mass in the suprasellar region, with homogneous enhancement by contrast medium and an accompanying low-density area in the left thalamus adjacent to the enhanced tumor mass. The histological diagnosis of the surgical specimen was ganglioglioma. Case 2. A 52-year-old female was admitted under the diagnosis of pituitary adenoma. Neurological examination showed bitemporal hemianopsia and signs of acromegaly. Plain skull X-ray film showed sellar ballooning and decalcification of the posterior clinoid process. The tumor resected in the first operation was histologically diagnosed as chromophobe adenoma mixed with ganglioglioma. In the follow-up, she showed signs and symptoms of a recurrent tumor, which was revealed to be ganglioglioma without any recurrence of chromophobe adenoma in the subsequent operations. The CT scan before the second operation showed an isodense supraand intrasellar mass with marked enhancement. Ganglioglioma is a rare, benign, nerve-cell tumor, mostly occurring in childhood and adolescence. The CT findings, together with the clinical history, the age of the patient, and the tumor location, may suggest the tentative preoperative diagnosis of ganglioglioma.

Concomitant Anticonvulsants With Bitemporal Electroconvulsive Therapy: A Randomized Controlled Trial With Clinical and Neurobiological Application.

Science.gov (United States)

Rakesh, Gopalkumar; Thirthalli, Jagadisha; Kumar, Channaveerachari Naveen; Muralidharan, Kesavan; Phutane, Vivek H; Gangadhar, Bangalore N

2017-03-01

Electroconvulsive therapy (ECT) is an effective treatment for major affective disorders. The combined use of ECT and anticonvulsant mood stabilizers is a common clinical scenario. There is dearth of systematic studies on the use of this combination with regard to clinical or cognitive outcomes. We aimed to compare clinical improvement and cognitive adverse effects between patients who received only ECT versus those who received ECT and anticonvulsants. We hypothesized that improvement would be fastest in patients who received only ECT. We conducted a randomized controlled trial in which patients prescribed ECT while being treated with anticonvulsants were randomized into 3 groups: full-dose (FD), half-dose (HD), and stop anticonvulsant. A blind rater assessed clinical improvement in patients using rating scales [Young's Mania Rating Scale (YMRS) and Clinical Global Impression] for clinical improvement and cognitive adverse effects (Postgraduate Institute memory scale). Analysis was done using mixed-effects modeling to delineate differences in clinical and cognitive outcomes across the 3 arms of the study over the course of ECT. Of the 54 patients recruited, 36 patients went into treatment allocation arms per the initial randomization plan. The main anticonvulsants prescribed were sodium valproate and carbamazepine. Patients in the 3 groups were comparable on clinical features. The most common diagnosis was bipolar affective disorder-with current episode of mania. Overall, there was no difference across the 3 groups in final clinical outcome scores (YMRS and Clinical Global Impression) when analyzed as intention to treat (ITT) or "as treated." In both analyses, group × time interaction was significant when comparing trend of YMRS scores between the FD anticonvulsant group and the HD group from baseline to last ECT (P = 0.0435 in ITT and P = 0.0055 in as treated). Patients in the FD group improved faster than those in the HD group. There were no differences across

A STUDY ON OPHTHALMIC MANIFESTATIONS IN PITUITARY GLAND TUMOURS

Directory of Open Access Journals (Sweden)

Chitra Munusamy Rajendran

2017-09-01

Full Text Available BACKGROUND Pituitary adenoma is a benign tumour that originates from the adenohypophyseal cells of the anterior lobe of pituitary gland. It accounts for 12% to 15% of all intracranial tumours. A spectrum of ocular manifestations are seen with these tumours ranging from the absence of any visual symptoms to severe visual field defects and loss of vision. The aim of the study is to study the various ocular features and its effect on vision, visual fields and ocular motility in cases of pituitary adenoma diagnosed on CT or MRI. MATERIALS AND METHODS This is a prospective study for a period of 1 year and 8 months conducted in Regional Institute of Ophthalmology, Madras Medical College. 25 patients aged between 25 to 65 years diagnosed as pituitary adenomas on radiological imaging who presented to squint clinic were evaluated after detailed history with visual acuity, pupillary reaction, colour vision, extraocular movements, slit lamp and fundus examination. Visual field examination was done with Octopus field analyser. RESULTS In our study, 25 patients of pituitary adenoma diagnosed on radio imaging were enrolled and evaluated. Most patients were above 50 years, 15 patients of the 25 were above 50 yrs. (60%. Females were predominantly affected (76%. Visual acquity of the patient was between 6/12-6/6 (62% on presentation. Headache was the commonest mode of presentation (80%. 76% showed field defects of which bitemporal hemianopia was the commonest in 52.9%. Pituitary macroadenoma 96% was the commonest type. Optic atrophy was seen only in 4 cases. Others had normal fundus. CONCLUSION Neuro-ophthalmic evaluation plays a major role not only in early detection, planning of treatment and further follow up, but also prevents visual loss if intervened early.

Generative Interpretation of Medical Images

DEFF Research Database (Denmark)

Stegmann, Mikkel Bille

2004-01-01

This thesis describes, proposes and evaluates methods for automated analysis and quantification of medical images. A common theme is the usage of generative methods, which draw inference from unknown images by synthesising new images having shape, pose and appearance similar to the analysed images......, handling of non-Gaussian variation by means of cluster analysis, correction of respiratory noise in cardiac MRI, and the extensions to multi-slice two-dimensional time-series and bi-temporal three-dimensional models. The medical applications include automated estimation of: left ventricular ejection...

Les particules illocutoires, variable d’ajustement de la traduction sous-titrante au cinéma

Directory of Open Access Journals (Sweden)

Ève Vayssière

2010-12-01

Full Text Available Die illokutiven Partikel fungieren als Anpassungsvariable, die beim Übersetzungsakt zur Untertitelung von Filmen entweder weggelassen werden oder erscheinen. Wenn sie einfach gelöscht werden, ergeben sich weder grammatikalische Störungen noch Informationsverlust. Das Auftauchen dieser Partikel in den deutschen Untertiteln zeigt jedoch, wie wichtig sie sind: Als Partikel der Oralität tragen sie zur Idiomatizität bei.Les particules illocutoires sont des variables d’ajustement lors de l’acte de traduction sous-titrante au cinéma, elles peuvent être supprimées sans que cela occasionne de dysfonctionnement grammatical et elles disparaissent lors de la traduction en français sans que cela occasionne une perte d’informations. Leur apparition dans les sous-titres allemands montre néanmoins leur importance : particules de l’oralité, elles sont vecteur d’« idiomaticité ».

[Transcranial magnetic therapy in the treatment of psychoautonomous disturbances in children with diabetes mellitus type 1].

Science.gov (United States)

Filina, N Iu; Bolotova, N V; Manukian, V Iu; Nikolaeva, N V; Kompaniets, O V

2009-01-01

Results of a clinical-physiological study of 80 children with diabetes mellitus type 1 with psychoautonomous disturbances are presented. Forty patients of the main group received transcranial magnetic therapy (TcMT), 40 patients of the control group had placebo sessions of TcMT with magnetic power supply switched off. TcMT was applied using bitemporal method, running regime with modulation frequency 1-10 Hz. Patients received 10 sessions. Positive changes were found in the main group compared to the controls. In the main group, TcMT sessions allowed to normalize the autonomous status in 75% of children and to improve psychoemotional state in 55%. The correction of psychoemotional status of children changed their behavior towards diabetes, improved control and compensation of the disease.

Parahippocampal epilepsy with subtle dysplasia: A cause of "imaging negative" partial epilepsy.

Science.gov (United States)

Pillay, Neelan; Fabinyi, Gavin C A; Myles, Terry S; Fitt, Gregory J; Berkovic, Samuel F; Jackson, Graeme D

2009-12-01

Lesion-negative refractory partial epilepsy is a major challenge in the assessment of patients for potential surgery. Finding a potential epileptogenic lesion simplifies assessment and is associated with good outcome. Here we describe imaging features of subtle parahippocampal dysplasia in five cases that were initially assessed as having imaging-negative frontal or temporal lobe epilepsy. We analyzed the clinical and imaging features of five patients with seizures from the parahippocampal region. Five patients had subtle but distinctive magnetic resonance imaging (MRI) abnormalities in the parahippocampal gyrus. This was a unilateral signal abnormality in the parahippocampal white matter extending into gray matter on heavily T(1)- and T(2)-weighted images with relative preservation of the gray-white matter boundary on T(1)-weighted volume sequences. Only one of these patients had typical electroclinical unilateral temporal lobe epilepsy (TLE); one mimicked frontal lobe epilepsy, two showed bitemporal seizures, and one had unlocalized partial seizures. All have had surgery; four are seizure-free (one has occasional auras only, follow-up 6 months to 10 years), and one has a >50% seizure reduction. Histopathologic evaluation suggested dysplastic features in the surgical specimens in all. In patients with lesion-negative partial epilepsy with frontal or temporal semiology, or in cases with apparent bitemporal seizures, subtle parahippocampal abnormalities should be carefully excluded. Recognizing the MRI findings of an abnormal parahippocampal gyrus can lead to successful surgery without invasive monitoring, despite apparently incongruent electroclinical features.

Demência semântica: avaliação clínica e de neuroimagem. Relato de caso Semantic dementia: clinical and neuroimaging evaluation. Case report

Directory of Open Access Journals (Sweden)

Leonardo Caixeta

2005-06-01

Full Text Available A demência semântica é uma síndrome clínica que faz parte do grupo das degenerações lobares frontotemporais. Relatamos o caso de um homem de 63 anos que aos 57 anos inicia comprometimento da memória semântica tanto para material visual quanto principalmente verbal. Alterações leves de comportamento estavam presentes e relacionadas com reações exageradas a estímulos dolorosos e comportamentos repetitivos. Os exames de neuroimagem estrutural e funcional evidenciaram comprometimento bitemporal assimétrico, predominando à esquerda. Diagnóstico diferencial deve ser feito com a doença de Alzheimer, outros representantes do grupo das degenerações lobares frontotemporais e qualquer síndrome que se apresente com uma afasia fluente progressiva.Semantic dementia is a clinical syndrome in the spectrum of frontotemporal lobar degeneration group. We report on a 63 years old man who presented with memory disorder of semantic nature for visual and mainly verbal material when he was 57 years old. Mild behavior impairment was present and related to exaggerated responses to algic stimuli and repetitive behavior. Structural and functional neuroimaging methods disclosed asymmetric bitemporal damage, mainly on the left. Differential diagnosis should be considered with Alzheimer's disease, another subtypes of the frontotemporal lobar degeneration group and any other syndrome that presents with a fluent aphasic progressive disorder.

Nationwide Hybrid Change Detection of Buildings

Science.gov (United States)

Hron, V.; Halounova, L.

2016-06-01

The Fundamental Base of Geographic Data of the Czech Republic (hereinafter FBGD) is a national 2D geodatabase at a 1:10,000 scale with more than 100 geographic objects. This paper describes the design of the permanent updating mechanism of buildings in FBGD. The proposed procedure belongs to the category of hybrid change detection (HCD) techniques which combine pixel-based and object-based evaluation. The main sources of information for HCD are cadastral information and bi-temporal vertical digital aerial photographs. These photographs have great information potential because they contain multispectral, position and also elevation information. Elevation information represents a digital surface model (DSM) which can be obtained using the image matching technique. Pixel-based evaluation of bi-temporal DSMs enables fast localization of places with potential building changes. These coarse results are subsequently classified through the object-based image analysis (OBIA) using spectral, textural and contextual features and GIS tools. The advantage of the two-stage evaluation is the pre-selection of locations where image segmentation (a computationally demanding part of OBIA) is performed. It is not necessary to apply image segmentation to the entire scene, but only to the surroundings of detected changes, which contributes to significantly faster processing and lower hardware requirements. The created technology is based on open-source software solutions that allow easy portability on multiple computers and parallelization of processing. This leads to significant savings of financial resources which can be expended on the further development of FBGD.

Bitemporal hypometabolism in Creutzfeldt-Jakob Disease measured by positron emission tomography with (F-18)2-fluorodeoxyglucose

International Nuclear Information System (INIS)

Friedland, R.P.; Budinger, T.F.; Prusiner, S.B.; Jagust, W.J.

1984-01-01

It is well established that Creutzfeldt-Jakob Disease (CJD) is caused by a slow infectious agent similar to the scrapie prion. However, the pathogenesis of this infection is poorly understood. Positron emission tomography (PET) was performed on a 54 year old male subject with autopsy confirmed CJD using (F-18)2-fluorodeoxyglucose (FDG) and the Donner 280-crystal tomograph. An x-ray computed tomographic study of the brain performed 4 days prior to PET was normal. In the PET study the frontal to temporal cortex difference of activity densities was 30% on the left and 12% on the right, reflecting temporal hypometabolism. The left-right temporal cortex difference of activity density was 25%, documenting marked hemispheric asymmetry. These findings are similar to those previously obtained in PET-FDG studies of patients with clinically defined Alzheimer's Disease (AD) and are distinctly different from PET-FDG finding in patients with other dementing illnesses or in healthy aged subjects. Recent work has demonstrated extensive biological similarities between CJD, scrapie and AD. The similarities in the regional metabolic alterations between CJD and AD provide additional evidence for the hypothesis that AD is caused by a slow infectious (prion-like) pathogen

Bitemporal hypometabolism in Creutzfeldt-Jakob Disease measured by positron emission tomography with (F-18)2-fluorodeoxyglucose

Energy Technology Data Exchange (ETDEWEB)

Friedland, R.P.; Budinger, T.F.; Prusiner, S.B.; Jagust, W.J.

1984-01-01

It is well established that Creutzfeldt-Jakob Disease (CJD) is caused by a slow infectious agent similar to the scrapie prion. However, the pathogenesis of this infection is poorly understood. Positron emission tomography (PET) was performed on a 54 year old male subject with autopsy confirmed CJD using (F-18)2-fluorodeoxyglucose (FDG) and the Donner 280-crystal tomograph. An x-ray computed tomographic study of the brain performed 4 days prior to PET was normal. In the PET study the frontal to temporal cortex difference of activity densities was 30% on the left and 12% on the right, reflecting temporal hypometabolism. The left-right temporal cortex difference of activity density was 25%, documenting marked hemispheric asymmetry. These findings are similar to those previously obtained in PET-FDG studies of patients with clinically defined Alzheimer's Disease (AD) and are distinctly different from PET-FDG finding in patients with other dementing illnesses or in healthy aged subjects. Recent work has demonstrated extensive biological similarities between CJD, scrapie and AD. The similarities in the regional metabolic alterations between CJD and AD provide additional evidence for the hypothesis that AD is caused by a slow infectious (prion-like) pathogen.

A case of radiation optic neuropathy after irradiation for pituitary adenoma

Energy Technology Data Exchange (ETDEWEB)

Ohta, Masahiro; Sasaki, Ushio; Shinohara, Nobuya; Takeda, Tetsuji; Chaki, Takanori; Nishigakiuchi, Keiji; Kusunoki, Katsusuke (Ehime Prefectural Central Hospital, Matsuyama (Japan))

1992-05-01

A 60-year-old woman with radiation optic neuropathy 21 months after irradiation is reported. The patient received a total dose of 50 Gy in 25 fractions for 39 days for pituitary adenoma. She presented with bitemporal hemianopsia and loss of recent memory. Gadolinium-enhanced T1-weighted imaging was very useful for detecting lesions in the optic nerves and chiasm to the hypothalamus including mamillary bodies. Two-month steroid therapy was effective in preventing the disease progression, although visual loss and loss of recent memory were not improved. (N.K.).

MAGNETIC SYMPATHICUS CORRECTION IN TREATMENT ENURESIS IN CHILDREN

Directory of Open Access Journals (Sweden)

T. V. Otpuschennikova

2014-01-01

Full Text Available Based on a investigation 92 children aged 6 to 15 years with enuresis shown to be effective use of physiotherapy in combination with a minimum dose of oxybutynin (2.5 mg at night. Physiotherapy is a combination of two types of magnetic therapy – transcranial method for bitemporal and cervical sympathetic ganglia on the neck-collar method. Therapeutic effect as reliever enuresis achieved in 76.6% of children. Positive dynamics of enuresis associated with the correction and improvement of adaptation hypersympathicotonia and autonomic nervous system.

A case of radiation optic neuropathy after irradiation for pituitary adenoma

International Nuclear Information System (INIS)

Ohta, Masahiro; Sasaki, Ushio; Shinohara, Nobuya; Takeda, Tetsuji; Chaki, Takanori; Nishigakiuchi, Keiji; Kusunoki, Katsusuke

1992-01-01

A 60-year-old woman with radiation optic neuropathy 21 months after irradiation is reported. The patient received a total dose of 50 Gy in 25 fractions for 39 days for pituitary adenoma. She presented with bitemporal hemianopsia and loss of recent memory. Gadolinium-enhanced T1-weighted imaging was very useful for detecting lesions in the optic nerves and chiasm to the hypothalamus including mamillary bodies. Two-month steroid therapy was effective in preventing the disease progression, although visual loss and loss of recent memory were not improved. (N.K.)

Idiopathic burning mouth syndrome: a common treatment-refractory somatoform condition responsive to ECT.

Science.gov (United States)

McGirr, Alexander; Davis, Lindsay; Vila-Rodriguez, Fidel

2014-04-30

Somatic symptom disorders are common causes of disability and suffering, and can pose significant management challenges. Idiopathic burning mouth syndrome is a challenging somatic symptom disorder with relatively high prevalence, particularly among post-menopausal women. Here, we present the case of a woman with severe treatment refractory idiopathic burning mouth syndrome and comorbid major depressive disorder, who was successfully treated with bitemporal electroconvulsive therapy. This case highlights the potential effectiveness of electroconvulsive therapy in idiopathic burning mouth syndrome when other treatment options have been exhausted. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Successful and rapid response to electroconvulsive therapy of a suicidal patient with comorbid bipolar I disorder and histrionic personality disorder.

Science.gov (United States)

Rapinesi, Chiara; Serata, Daniele; Del Casale, Antonio; Simonetti, Alessio; Milioni, Mara; Mazzarini, Lorenzo; Scatena, Paola; Fensore, Claudio; Carbonetti, Paolo; Kotzalidis, Giorgio D; Tatarelli, Roberto; Pompili, Maurizio; Girardi, Paolo

2012-03-01

A woman with bipolar disorder I, histrionic personality disorder, and suicidal ideation with repeated suicide attempts, who had been treated for 2 years with mood stabilizers, antipsychotics, and benzodiazepines, received a total of 8 bitemporal-biparietal electroconvulsive therapy sessions. Her suicidal ideation and self-harm behavior disappeared immediately after the first session and her psychopathology soon after. This supports the existence of a relatively independent suicidal syndrome and confirms data on its immediate responsiveness to electroconvulsive therapy. Electroconvulsive therapy must not be long withheld from patients with such characteristics to reduce unnecessary sufferance and suicidality.

Evaluating an ensemble classification approach for crop diversityverification in Danish greening subsidy control

DEFF Research Database (Denmark)

Chellasamy, Menaka; Ferre, Ty; Greve, Mogens Humlekrog

2016-01-01

Beginning in 2015, Danish farmers are obliged to meet specific crop diversification rules based on total land area and number of crops cultivated to be eligible for new greening subsidies. Hence, there is a need for the Danish government to extend their subsidy control system to verify farmers......’ declarations to war-rant greening payments under the new crop diversification rules. Remote Sensing (RS) technology has been used since 1992 to control farmers’ subsidies in Denmark. However, a proper RS-based approach is yet to be finalised to validate new crop diversity requirements designed for assessing...... compliance under the recent subsidy scheme (2014–2020); This study uses an ensemble classification approach(proposed by the authors in previous studies) for validating the crop diversity requirements of the new rules. The approach uses a neural network ensemble classification system with bi-temporal (spring...

Outcome of temporal lobe epilepsy surgery evaluated with bitemporal intracranial electrode recordings.

Science.gov (United States)

Massot-Tarrús, Andreu; Steven, David A; McLachlan, Richard S; Mirsattari, Seyed M; Diosy, David; Parrent, Andrew G; Blume, Warren T; Girvin, John P; Burneo, Jorge G

2016-11-01

Temporal lobe epilepsy (TLE) with unclear lateralization may require intracranial implantation of electrodes (IIE). We retrospectively assessed the association between the use of IIE and long-term outcomes in patients undergoing anterior temporal lobectomy (ATL). We retrospectively reviewed the records of 1,032 patients undergoing epilepsy surgery at our center from 1977 to 2006. Patients who underwent ATL were included. Seizure outcome was assessed through final follow-up. Those who underwent scalp and IIE (mostly evaluated with temporal subdural strip electrodes) were compared. From 497 patients who underwent ATL, 139 did so after IIE placement in the temporal lobes. Mean age at surgery was 32.3±12.3years and median duration of follow-up 24 months (range: 6-36). Fifty-three percent of those evaluated with IIE were seizure-free at their last available visit (vs. 68% evaluated with only scalp EEG, p=0.002). Patients with lesional TLE generally had a better outcome (65.5% seizure free) than those without lesions (56.3%, p=0.093), especially for unilateral TLE diagnosed with IIE. In a multivariate Cox regression analyses adjusted for gender, neuropsychological concordance, pathological findings, and post-operative seizures, bilateral TLE predicted seizure recurrence in IIE patients (HR=2.08, 95% CI: 1.08-4.0, p=0.029). More than a half of those who undergo IIE in suspected TLE are seizure free after ATL. IIE allows for the identification of surgical candidates. Copyright © 2016 Elsevier B.V. All rights reserved.

[Optimization of enuresis therapy in children using transcranial magnetotherapy].

Science.gov (United States)

Otpushchennikova, T V; Kazanskaia, I V; Volkov, S V; Raĭgorodskaia, Iu M

2010-01-01

A total of 58 children (age from 6 to 14 years) suffering from nocturnal enuresis (NE) were divided into two groups. The study group received basic therapy (driptan dose was reduced to 2.5 mg twice a day) in combination with transcranial bitemporal magnetotherapy (TcMT). The control group received placebo TcMT and basic therapy. It is shown that addition of TcMT to reduced basic therapy lowered the score of imperative voiding symptoms 1.3-fold, number of enuresis patients 1.7-fold, volume of the bladder 6.8 months after the treatment 1.9-fold, corrected vegetative status and activity of the subcortical nervous center in 24% children according to cardiointervalography versus the controls. Thus, TcMT improves clinical effect in NE patients in 2-fold reduction of pharmacological burden.

NATIONWIDE HYBRID CHANGE DETECTION OF BUILDINGS

Directory of Open Access Journals (Sweden)

V. Hron

2016-06-01

Full Text Available The Fundamental Base of Geographic Data of the Czech Republic (hereinafter FBGD is a national 2D geodatabase at a 1:10,000 scale with more than 100 geographic objects. This paper describes the design of the permanent updating mechanism of buildings in FBGD. The proposed procedure belongs to the category of hybrid change detection (HCD techniques which combine pixel-based and object-based evaluation. The main sources of information for HCD are cadastral information and bi-temporal vertical digital aerial photographs. These photographs have great information potential because they contain multispectral, position and also elevation information. Elevation information represents a digital surface model (DSM which can be obtained using the image matching technique. Pixel-based evaluation of bi-temporal DSMs enables fast localization of places with potential building changes. These coarse results are subsequently classified through the object-based image analysis (OBIA using spectral, textural and contextual features and GIS tools. The advantage of the two-stage evaluation is the pre-selection of locations where image segmentation (a computationally demanding part of OBIA is performed. It is not necessary to apply image segmentation to the entire scene, but only to the surroundings of detected changes, which contributes to significantly faster processing and lower hardware requirements. The created technology is based on open-source software solutions that allow easy portability on multiple computers and parallelization of processing. This leads to significant savings of financial resources which can be expended on the further development of FBGD.

A thyrotropin-secreting macroadenoma with positive growth hormone and prolactin immunostaining: A case report and literature review.

Science.gov (United States)

Kuzu, F; Bayraktaroğlu, T; Zor, F; G N, B D; Salihoğlu, Y S; Kalaycı, M

2015-01-01

Thyrotropin (thyroid stimulating hormone [TSH]) secreting pituitary adenomas (TSHoma) are rare adenomas presenting with hyperthyroidism due to impaired negative feedback of thyroid hormone on the pituitary and inappropriate TSH secretion. This article presents a case of TSH-secreting macroadenoma without any clinical hyperthyroidism symptoms accompanying immunoreaction with growth hormone (GH) and prolactin. A 36-year-old female patient was admitted with complaints of irregular menses and blurred vision. On physical exam, she had bitemporal hemianopsia defect. Magnetic resonance imaging (MRI) evaluation showed suprasellar macroadenoma measuring 33 mm × 26 mm × 28 mm was detected on pituitary MRI. She had no hyperthyroidism symptoms clinically. Although free T4 and free T3 levels were elevated, TSH level was inappropriately within the upper limit of normal. Response to T3 suppression and thyrotropin releasing hormone-stimulation test was inadequate. Other pituitary hormones were normal. Transsphenoidal adenomectomy was performed due to parasellar compression findings. Immunohistochemically widespread reaction was observed with TSH, GH and prolactin in the adenoma. The patient underwent a second surgical procedure 2 months later due to macroscopic residual tumor, bitemporal hemianopsia and a suprasellar homogenous uptake with regular borders on indium-111 octreotide scintigraphy. After second surgery; due to ongoing symptoms and residual tumor, she was managed with octreotide and cabergoline treatment. On her follow-up with medical treatment, TSH and free T4 values were within normal limits. Although silent TSHomas are rare, they may arise with compression symptoms as in our case. The differential diagnosis of secondary hyperthyroidism should include TSHomas and thyroid hormone receptor resistance syndrome.

Pituitary Gigantism: A Case Report

Directory of Open Access Journals (Sweden)

Rana Bhattacharjee

2012-01-01

Full Text Available Objective: To present a rare case of gigantism. Case Report: A 25-year-old lady presented with increased statural growth and enlarged body parts noticed since the age of 14 years, primary amenorrhea, and frontal headache for the last 2 years.She has also been suffering from non-inflammatory low back pain with progressive kyphosis and pain in the knees, ankles, and elbows for the last 5 years. There was no history of visual disturbance, vomiting, galactorrhoea, cold intolerance. She had no siblings. Family history was non-contributory.Blood pressure was normal. Height 221 cm, weight 138 kg,body mass index (BMI28. There was coarsening of facial features along with frontal bossing and prognathism, large hands and feet, and small goitre. Patient had severe kyphosis and osteoarthritis of knees. Confrontation perimetry suggested bitemporal hemianopia. Breast and pubic hair were of Tanner stage 1. Serum insulin like growth factor-1 (IGF1 was 703 ng/ml with all glucose suppressedgrowth hormone (GHvalues of >40 ng/ml. Prolactin was 174 ng/ml. Basal serum Lutenising Hormone (LH, follicle stimulating Hormone (FSH was low. Oral glucose tolerance test (OGTT, liver and renal function tests, basal cortisol and thyroid profile, Calcium, phosphorus and Intact Parathyroid hormone (iPTH were normal.Computed tomographyscan of brain showed large pituitary macroadenoma. Automated perimetry confirmed bitemporal hemianopia. A diagnosis of gigantism due to GH secreting pituitary macroadenoma with hypogonadotrophichypogonadism was made. Debulking pituitary surgery followed by somatostatin analogue therapy with gonadal steroid replacement had been planned, but the patient refused further treatment.

Pituitary gigantism: a case report.

Science.gov (United States)

Bhattacharjee, Rana; Roy, Ajitesh; Goswami, Soumik; Selvan, Chitra; Chakraborty, Partha P; Ghosh, Sujoy; Biswas, Dibakar; Dasgupta, Ranen; Mukhopadhyay, Satinath; Chowdhury, Subhankar

2012-12-01

To present a rare case of gigantism. A 25-year-old lady presented with increased statural growth and enlarged body parts noticed since the age of 14 years, primary amenorrhea, and frontal headache for the last 2 years. She has also been suffering from non-inflammatory low back pain with progressive kyphosis and pain in the knees, ankles, and elbows for the last 5 years. There was no history of visual disturbance, vomiting, galactorrhoea, cold intolerance. She had no siblings. Family history was non-contributory. Blood pressure was normal. Height 221 cm, weight 138 kg, body mass index (BMI)28. There was coarsening of facial features along with frontal bossing and prognathism, large hands and feet, and small goitre. Patient had severe kyphosis and osteoarthritis of knees. Confrontation perimetry suggested bitemporal hemianopia. Breast and pubic hair were of Tanner stage 1. Serum insulin like growth factor-1 (IGF1) was 703 ng/ml with all glucose suppressedgrowth hormone (GH)values of >40 ng/ml. Prolactin was 174 ng/ml. Basal serum Lutenising Hormone (LH), follicle stimulating Hormone (FSH) was low. Oral glucose tolerance test (OGTT), liver and renal function tests, basal cortisol and thyroid profile, Calcium, phosphorus and Intact Parathyroid hormone (iPTH) were normal. Computed tomographyscan of brain showed large pituitary macroadenoma. Automated perimetry confirmed bitemporal hemianopia. A diagnosis of gigantism due to GH secreting pituitary macroadenoma with hypogonadotrophichypogonadism was made. Debulking pituitary surgery followed by somatostatin analogue therapy with gonadal steroid replacement had been planned, but the patient refused further treatment.

Landslide Inventory Mapping from Bitemporal 10 m SENTINEL-2 Images Using Change Detection Based Markov Random Field

Science.gov (United States)

Qin, Y.; Lu, P.; Li, Z.

2018-04-01

Landslide inventory mapping is essential for hazard assessment and mitigation. In most previous studies, landslide mapping was achieved by visual interpretation of aerial photos and remote sensing images. However, such method is labor-intensive and time-consuming, especially over large areas. Although a number of semi-automatic landslide mapping methods have been proposed over the past few years, limitations remain in terms of their applicability over different study areas and data, and there is large room for improvement in terms of the accuracy and automation degree. For these reasons, we developed a change detection-based Markov Random Field (CDMRF) method for landslide inventory mapping. The proposed method mainly includes two steps: 1) change detection-based multi-threshold for training samples generation and 2) MRF for landslide inventory mapping. Compared with the previous methods, the proposed method in this study has three advantages: 1) it combines multiple image difference techniques with multi-threshold method to generate reliable training samples; 2) it takes the spectral characteristics of landslides into account; and 3) it is highly automatic with little parameter tuning. The proposed method was applied for regional landslides mapping from 10 m Sentinel-2 images in Western China. Results corroborated the effectiveness and applicability of the proposed method especially the capability of rapid landslide mapping. Some directions for future research are offered. This study to our knowledge is the first attempt to map landslides from free and medium resolution satellite (i.e., Sentinel-2) images in China.

Bitemporal hypometabolism in Creutzfeldt-Jakob disease measured by positron emission tomography with [18F]-2-fluorodeoxyglucose

International Nuclear Information System (INIS)

Friedland, R.P.; Prusiner, S.B.; Jagust, W.J.; Budinger, T.F.; Davis, R.L.

1984-01-01

It is well established that Creutzfeldt-Jakob disease (CJD) is caused by a slow infectious agent similar to the scrapie prion. However, the pathogenesis of this infection is poorly understood. Positron emission tomography (PET) was performed on a 54-year-old man with autopsy confirmed CJD using [18F]-2-fluorodeoxyglucose (FDG) and the Donner 280-crystal tomograph. Temporal lobe hypometabolism with hemispheric asymmetry was observed. These findings are similar to those previously obtained in PET-FDG studies of patients with clinically defined Alzheimer disease (AD). The similarities in the regional metabolic alterations between CJD and AD provide additional evidence for the possibility that AD may be caused by a slow infectious prion

Childhood temporal lobe epilepsy: correlation between electroencephalography and magnetic resonance spectroscopy: a case-control study.

Science.gov (United States)

Azab, Seham Fa; Sherief, Laila M; Saleh, Safaa H; Elshafeiy, Mona M; Siam, Ahmed G; Elsaeed, Wafaa F; Arafa, Mohamed A; Bendary, Eman A; Sherbiny, Hanan S; Elbehedy, Rabab M; Aziz, Khalid A

2015-04-18

The diagnosis of epilepsy should be made as early as possible to give a child the best chance for treatment success and also to decrease complications such as learning difficulties and social and behavioral problems. In this study, we aimed to assess the ability of magnetic resonance spectroscopy (MRS) in detecting the lateralization side in patients with Temporal lobe epilepsy (TLE) in correlation with EEG and MRI findings. This was a case-control study including 40 patients diagnosed (clinically and by EEG) as having temporal lobe epilepsy aged 8 to 14 years (mean, 10.4 years) and 20 healthy children with comparable age and gender as the control group. All patients were subjected to clinical examination, interictal electroencephalography and magnetic resonance imaging (MRI). Proton magnetic resonance spectroscopic examination (MRS) was performed to the patients and the controls. According to the findings of electroencephalography, our patients were classified to three groups: Group 1 included 20 patients with unitemporal (lateralized) epileptic focus, group 2 included 12 patients with bitemporal (non-lateralized) epileptic focus and group 3 included 8 patients with normal electroencephalography. Magnetic resonance spectroscopy could lateralize the epileptic focus in 19 patients in group 1, nine patients in group2 and five patients in group 3 with overall lateralization of (82.5%), while electroencephalography was able to lateralize the focus in (50%) of patients and magnetic resonance imaging detected lateralization of mesial temporal sclerosis in (57.5%) of patients. Magnetic resonance spectroscopy is a promising tool in evaluating patients with epilepsy and offers increased sensitivity to detect temporal pathology that is not obvious on structural MRI imaging.

Support Vector Machines for Multitemporal and Multisensor Change Detection in a Mining Area

Science.gov (United States)

Hecheltjen, Antje; Waske, Bjorn; Thonfeld, Frank; Braun, Matthias; Menz, Gunter

2010-12-01

Long-term change detection often implies the challenge of incorporating multitemporal data from different sensors. Most of the conventional change detection algorithms are designed for bi-temporal datasets from the same sensors detecting only the existence of changes. The labeling of change areas remains a difficult task. To overcome such drawbacks, much attention has been given lately to algorithms arising from machine learning, such as Support Vector Machines (SVMs). While SVMs have been applied successfully for land cover classifications, the exploitation of this approach for change detection is still in its infancy. Few studies have already proven the applicability of SVMs for bi- and multitemporal change detection using data from one sensor only. In this paper we demonstrate the application of SVM for multitemporal and -sensor change detection. Our study site covers lignite open pit mining areas in the German state North Rhine-Westphalia. The dataset consists of bi-temporal Landsat data and multi-temporal ERS SAR data covering two time slots (2001 and 2009). The SVM is conducted using the IDL program imageSVM. Change is deduced from one time slot to the next resulting in two change maps. In contrast to change detection, which is based on post-classification comparison, change detection is seen here as a specific classification problem. Thus, changes are directly classified from a layer-stack of the two years. To reduce the number of change classes, we created a change mask using the magnitude of Change Vector Analysis (CVA). Training data were selected for different change classes (e.g. forest to mining or mining to agriculture) as well as for the no-change classes (e.g. agriculture). Subsequently, they were divided in two independent sets for training the SVMs and accuracy assessment, respectively. Our study shows the applicability of SVMs to classify changes via SVMs. The proposed method yielded a change map of reclaimed and active mines. The use of ERS SAR

Pituitary apoplexy in a teenager--case report.

Science.gov (United States)

Chao, Chen-Cheng; Lin, Chun-Ju

2014-06-01

Pituitary apoplexy is a rare clinical emergency which results from hemorrhage or infarction in the pituitary gland. We present a 14-year-old girl with pituitary apoplexy and review the literature. Our patient experienced blurred vision, nausea, and headache. Her best-corrected visual acuity was 20/200 and 20/20. Confrontation test visual field testing revealed bitemporal hemianopsia. Brain imaging demonstrated a suprasellar mass. The microscopic endonasal transsphenoidal approach only found 5-10 mL brownish fluid-like material. Pathology confirmed no malignancy. Pituitary apoplexy was diagnosed. Her nausea and headache gradually improved. Six months after operation, her best-corrected visual acuity had improved to 20/30 and 20/20. Although pituitary apoplexy is rare in pediatric patients, prompt evaluation including detailed ophthalmic examination, biochemical evaluation, endocrine workup, and image study are very important. Copyright © 2014 Elsevier Inc. All rights reserved.

Extended Endoscopic Endonasal Approach for Craniopharyngioma Removal.

Science.gov (United States)

Messerer, Mahmoud; Maduri, Rodolfo; Daniel, Roy Thomas

2018-02-01

Objective  Endoscopic transsphenoidal extended endoscopic approach (EEA) represents a valid alternative to microsurgery for craniopharyngiomas removal, especially for retrochiasmatic lesions without large parasellar extension. The present video illustrates the salient surgical steps of the EEA for craniopahryngioma removal. Patient  A 52-year-old man presented with a bitemporal hemianopia and a bilateral decreased visual acuity. MRI showed a Kassam type III cystic craniopharyngioma with a solid component ( Fig. 1 , panels A and B). Surgical Procedure  The head is rotated 10 degrees toward the surgeons. The nasal step is started through the left nostril with a middle turbinectomy. A nasoseptal flap is harvested and positioned in the left choana. The binostril approach allows a large sphenoidotomy to expose the key anatomic landmarks. The craniotomy boundaries are the planum sphenoidale superiorly, the median opticocarotid recesses, the internal carotid artery laterally and the clival recess inferiorly. After dural opening and superior intercavernous sinus coagulation, the tumor is entirely removed ( Fig. 2 , panels A and B). Skull base reconstruction is ensured by fascia lata grafting and nasoseptal flap positioning. Results  Postoperative MRI showed the complete tumor resection ( Fig. 1 , panels C and D). At 3 months postoperatively, the bitemporal hemianopia regressed and the visual acuity improved. A novel left homonymous hemianopia developed secondary to optic tract manipulation. Conclusions  The extended EEA is a valid surgical approach for craniopharyngioma resection. A comprehensive knowledge of the sellar and parasellar anatomy is mandatory for safe tumor removal with decreased morbidity and satisfactory oncologic results. The link to the video can be found at: https://youtu.be/NrCPPnVK2qA .

Performance Evaluation of Three Different High Resolution Satellite Images in Semi-Automatic Urban Illegal Building Detection

Science.gov (United States)

Khalilimoghadama, N.; Delavar, M. R.; Hanachi, P.

2017-09-01

The problem of overcrowding of mega cities has been bolded in recent years. To meet the need of housing this increased population, which is of great importance in mega cities, a huge number of buildings are constructed annually. With the ever-increasing trend of building constructions, we are faced with the growing trend of building infractions and illegal buildings (IBs). Acquiring multi-temporal satellite images and using change detection techniques is one of the proper methods of IB monitoring. Using the type of satellite images with different spatial and spectral resolutions has always been an issue in efficient detection of the building changes. In this research, three bi-temporal high-resolution satellite images of IRS-P5, GeoEye-1 and QuickBird sensors acquired from the west of metropolitan area of Tehran, capital of Iran, in addition to city maps and municipality property database were used to detect the under construction buildings with improved performance and accuracy. Furthermore, determining the employed bi-temporal satellite images to provide better performance and accuracy in the case of IB detection is the other purpose of this research. The Kappa coefficients of 70 %, 64 %, and 68 % were obtained for producing change image maps using GeoEye-1, IRS-P5, and QuickBird satellite images, respectively. In addition, the overall accuracies of 100 %, 6 %, and 83 % were achieved for IB detection using the satellite images, respectively. These accuracies substantiate the fact that the GeoEye-1 satellite images had the best performance among the employed images in producing change image map and detecting the IBs.

Determinants of brain metabolism changes in mesial temporal lobe epilepsy.

Science.gov (United States)

Chassoux, Francine; Artiges, Eric; Semah, Franck; Desarnaud, Serge; Laurent, Agathe; Landre, Elisabeth; Gervais, Philippe; Devaux, Bertrand; Helal, Ourkia Badia

2016-06-01

To determine the main factors influencing metabolic changes in mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis (HS). We prospectively studied 114 patients with MTLE (62 female; 60 left HS; 15- to 56-year-olds) with (18) F-fluorodeoxyglucose-positron emission tomography and correlated the results with the side of HS, structural atrophy, electroclinical features, gender, age at onset, epilepsy duration, and seizure frequency. Imaging processing was performed using statistical parametric mapping. Ipsilateral hypometabolism involved temporal (mesial structures, pole, and lateral cortex) and extratemporal areas including the insula, frontal lobe, perisylvian regions, and thalamus, more extensively in right HS (RHS). A relative increase of metabolism (hypermetabolism) was found in the nonepileptic temporal lobe and in posterior areas bilaterally. Voxel-based morphometry detected unilateral hippocampus atrophy and gray matter concentration decrease in both frontal lobes, more extensively in left HS (LHS). Regardless of the structural alterations, the topography of hypometabolism correlated strongly with the extent of epileptic networks (mesial, anterior-mesiolateral, widespread mesiolateral, and bitemporal according to the ictal spread), which were larger in RHS. Notably, widespread perisylvian and bitemporal hypometabolism was found only in RHS. Mirror hypermetabolism was grossly proportional to the hypometabolic areas, coinciding partly with the default mode network. Gender-related effect was significant mainly in the contralateral frontal lobe, in which metabolism was higher in female patients. Epilepsy duration correlated with the contralateral temporal metabolism, positively in LHS and negatively in RHS. Opposite results were found with age at onset. High seizure frequency correlated negatively with the contralateral metabolism in LHS. Epileptic networks, as assessed by electroclinical correlations, appear to be the main determinant of

Deep Learning of Post-Wildfire Vegetation Loss using Bitemporal Synthetic Aperture Radar Images

Science.gov (United States)

Chen, Z.; Glasscoe, M. T.; Parker, J. W.

2017-12-01

Wildfire events followed by heavy precipitation have been proven causally related to breakouts of mudflow or debris flow, which, can demand rapid evacuation and threaten residential communities and civil infrastructure. For example, in the case of the city of Glendora, California, it was first afflicted by a severe wildfire in 1968 and then the flooding caused mudslides and debris flow in 1969 killed 34 people. Therefore, burn area or vegetation loss mapping due to wildfire is critical to agencies for preparing for secondary hazards, particularly flooding and flooding induced mudflow. However, rapid post-wildfire mapping of vegetation loss mapping is not readily obtained by regular remote sensing methods, e.g. various optical methods, due to the presence of smoke, haze, and rainy/cloudy conditions that often follow a wildfire event. In this paper, we will introduce and develop a deep learning-based framework that uses Synthetic Aperture Radar images collected prior to and after a wildfire event. A convolutional neural network (CNN) approach will be used that replaces traditional principle component analysis (PCA) based differencing for non-supervised change feature extraction. Using a small sample of human-labeled burned vegetation, normal vegetation, and urban built-up pixels, we will compare the performance of deep learning and PCA-based feature extraction. The 2014 Coby Fire event, which affected the downstream city of Glendora, was used to evaluate the proposed framework. The NASA's UAVSAR data (https://uavsar.jpl.nasa.gov/) will be utilized for mapping the vegetation damage due to the Coby Fire event.

LANDSLIDE INVENTORY MAPPING FROM BITEMPORAL 10 m SENTINEL-2 IMAGES USING CHANGE DETECTION BASED MARKOV RANDOM FIELD

Directory of Open Access Journals (Sweden)

Y. Qin

2018-04-01

Full Text Available Landslide inventory mapping is essential for hazard assessment and mitigation. In most previous studies, landslide mapping was achieved by visual interpretation of aerial photos and remote sensing images. However, such method is labor-intensive and time-consuming, especially over large areas. Although a number of semi-automatic landslide mapping methods have been proposed over the past few years, limitations remain in terms of their applicability over different study areas and data, and there is large room for improvement in terms of the accuracy and automation degree. For these reasons, we developed a change detection-based Markov Random Field (CDMRF method for landslide inventory mapping. The proposed method mainly includes two steps: 1 change detection-based multi-threshold for training samples generation and 2 MRF for landslide inventory mapping. Compared with the previous methods, the proposed method in this study has three advantages: 1 it combines multiple image difference techniques with multi-threshold method to generate reliable training samples; 2 it takes the spectral characteristics of landslides into account; and 3 it is highly automatic with little parameter tuning. The proposed method was applied for regional landslides mapping from 10 m Sentinel-2 images in Western China. Results corroborated the effectiveness and applicability of the proposed method especially the capability of rapid landslide mapping. Some directions for future research are offered. This study to our knowledge is the first attempt to map landslides from free and medium resolution satellite (i.e., Sentinel-2 images in China.

Bitemporal hypometabolism in Creutzfeldt-Jakob disease measured by positron emission tomography with (/sup 18/F)-2-fluorodeoxyglucose

Energy Technology Data Exchange (ETDEWEB)

Friedland, R.P.; Prusiner, S.B.; Jagust, W.J.; Budinger, T.F.; Davis, R.L.

1984-10-01

It is well established that Creutzfeldt-Jakob disease (CJD) is caused by a slow infectious agent similar to the scrapie prion. However, the pathogenesis of this infection is poorly understood. Positron emission tomography (PET) was performed on a 54-year-old man with autopsy confirmed CJD using (18F)-2-fluorodeoxyglucose (FDG) and the Donner 280-crystal tomograph. Temporal lobe hypometabolism with hemispheric asymmetry was observed. These findings are similar to those previously obtained in PET-FDG studies of patients with clinically defined Alzheimer disease (AD). The similarities in the regional metabolic alterations between CJD and AD provide additional evidence for the possibility that AD may be caused by a slow infectious prion.

Planum sphenoidale meningioma leading to visual disturbance.

Science.gov (United States)

Lutwak, Nancy; Dill, Curt; Wieczorek, Rosemary

2011-08-31

A 60-year-old male presented with complaints of dizziness, which worsened with fatigue and a sense his balance was 'off'. Initial physical examination was negative and the laboratory testing was unremarkable. Within weeks, the patient developed bilateral visual field deficits. MRI revealed an extra-axial mass which extended into the pituitary fossa and caused compression of the pituitary gland. The pituitary stalk was displaced posteriorly and the optic chiasm was compressed with displacement superiorly and posteriorly. The patient underwent a surgical resection. Diabetes insipidus developed postoperatively requiring a vasopressin drip. He also developed hypopituitarism after the resection with hypothyroidism, hypoadrenalism and hypogonadism. The patient requires testosterone, levothyroxine and hydrocortisone replacement and has mild residual bitemporal hemianopsia.

Spontaneous regression of pituitary mass in temporal association with pregnancy

Energy Technology Data Exchange (ETDEWEB)

Ikeda, H.; Okudaira, Y.

1987-09-01

We have encountered a case of a pituitary mass which emerged and enlarged during pregnancy in a 29-year-old woman. On CT scanning the mass disappeared over the course of four months postpartum and was followed by pituitary hypofunction. The hypofunction was restricted to ACTH, GH, and PRL. The visual field defects, bitemporal hemianopsia, disappeared with disappearance of the pituitary mass on CT scanning, indicating that such deficits during this period were reversible. Based on the clinical course and laboratory data, this case is thought to have been lymphocytic adenohypophysitis. It was concluded that among pituitary tumors developing during pregnancy there are some such cases which do not require surgical therapy.

Clinical utility of flumazenil-PET versus [18F]fluorodeoxyglucose-PET and MRI in refractory partial epilepsy. A prospective study in 100 patients.

Science.gov (United States)

Ryvlin, P; Bouvard, S; Le Bars, D; De Lamérie, G; Grégoire, M C; Kahane, P; Froment, J C; Mauguière, F

1998-11-01

We assessed the clinical utility of [11C]flumazenil-PET (FMZ-PET) prospectively in 100 epileptic patients undergoing a pre-surgical evaluation, and defined the specific contribution of this neuro-imaging technique with respect to those of MRI and [18F]fluorodeoxyglucose-PET (FDG-PET). All patients benefited from a long term video-EEG monitoring, whereas an intracranial EEG investigation was performed in 40 cases. Most of our patients (73%) demonstrated a FMZ-PET abnormality; this hit rate was significantly higher in temporal lobe epilepsy (94%) than in other types of epilepsy (50%) (P lobe epilepsy associated with MRI signs of hippocampal sclerosis, FMZ-PET abnormalities delineated the site of seizure onset precisely, whenever they were coextensive with FDG-PET abnormalities; (ii) in bi-temporal epilepsy, FMZ-PET helped to confirm the bilateral origin of seizures by showing a specific pattern of decreased FMZ binding in both temporal lobes in 33% of cases; (iii) in patients with a unilateral cryptogenic frontal lobe epilepsy, FMZ-PET provided further evidence of the side and site of seizure onset in 55% of cases. Thus, FMZ-PET deserves to be included in the pre-surgical evaluation of these specific categories of epileptic patients, representing approximately half of the population considered for epilepsy surgery.

Calcified neurocysticercosis lesions and hippocampal sclerosis: potential dual pathology?

Science.gov (United States)

Rathore, Chaturbhuj; Thomas, Bejoy; Kesavadas, Chandrasekharan; Radhakrishnan, Kurupath

2012-04-01

In areas where cysticercosis is endemic, calcified neurocysticercosis lesion(s) (CNL) and hippocampal sclerosis (HS) commonly coexist in patients with localization-related epilepsies. To understand the pathogenesis of HS associated with CNL, we compared the characteristics of three groups of patients with antiepileptic drug-resistant epilepsies: CNL with HS, CNL without HS (CNL alone), and HS without CNL (HS alone). In comparison to patients with CNL alone, those with CNL with HS had CNL more frequently located in the ipsilateral temporal lobe. Those with CNL with HS had a lower incidence of febrile seizures, older age at initial precipitating injury and at onset of habitual complex partial seizures, and more frequent clustering of seizures and extratemporal/bitemporal interictal epileptiform discharges as compared to patients with HS alone. Our study illustrates that HS associated with CNL might have a different pathophysiologic basis as compared to classical HS. Wiley Periodicals, Inc. © 2012 International League Against Epilepsy.

Temporal plus epilepsy is a major determinant of temporal lobe surgery failures.

Science.gov (United States)

Barba, Carmen; Rheims, Sylvain; Minotti, Lorella; Guénot, Marc; Hoffmann, Dominique; Chabardès, Stephan; Isnard, Jean; Kahane, Philippe; Ryvlin, Philippe

2016-02-01

Reasons for failed temporal lobe epilepsy surgery remain unclear. Temporal plus epilepsy, characterized by a primary temporal lobe epileptogenic zone extending to neighboured regions, might account for a yet unknown proportion of these failures. In this study all patients from two epilepsy surgery programmes who fulfilled the following criteria were included: (i) operated from an anterior temporal lobectomy or disconnection between January 1990 and December 2001; (ii) magnetic resonance imaging normal or showing signs of hippocampal sclerosis; and (iii) postoperative follow-up ≥ 24 months for seizure-free patients. Patients were classified as suffering from unilateral temporal lobe epilepsy, bitemporal epilepsy or temporal plus epilepsy based on available presurgical data. Kaplan-Meier survival analysis was used to calculate the probability of seizure freedom over time. Predictors of seizure recurrence were investigated using Cox proportional hazards model. Of 168 patients included, 108 (63.7%) underwent stereoelectroencephalography, 131 (78%) had hippocampal sclerosis, 149 suffered from unilateral temporal lobe epilepsy (88.7%), one from bitemporal epilepsy (0.6%) and 18 (10.7%) from temporal plus epilepsy. The probability of Engel class I outcome at 10 years of follow-up was 67.3% (95% CI: 63.4-71.2) for the entire cohort, 74.5% (95% CI: 70.6-78.4) for unilateral temporal lobe epilepsy, and 14.8% (95% CI: 5.9-23.7) for temporal plus epilepsy. Multivariate analyses demonstrated four predictors of seizure relapse: temporal plus epilepsy (P temporal lobe surgery failure was 5.06 (95% CI: 2.36-10.382) greater in patients with temporal plus epilepsy than in those with unilateral temporal lobe epilepsy. Temporal plus epilepsy represents a hitherto unrecognized prominent cause of temporal lobe surgery failures. In patients with temporal plus epilepsy, anterior temporal lobectomy appears very unlikely to control seizures and should not be advised. Whether larger

Evaluation of seizure propagation on ictal brain SPECT using statistical parametric mapping in temporal lobe epilepsy

International Nuclear Information System (INIS)

Jeon, Tae Joo; Lee, Jong Doo; Kim, Hee Joung; Lee, Byung In; Kim, Ok Joon; Kim, Min Jung; Jeon, Jeong Dong

1999-01-01

Ictal brain SPECT has a high diagnostic sensitivity exceeding 90 % in the localization of seizure focus, however, it often shows increased uptake within the extratemporal areas due to early propagation of seizure discharge. This study aimed to evaluate seizure propagation on ictal brian SPECT in patients with temporal lobe epilepsy (TLE) by statistical parametric mapping (SPM). Twenty-one patients (age 27.14 5.79 y) with temporal lobe epilepsy (right in 8, left in 13) who had successful seizure outcome after surgery and nine normal control were included. The data of ictal and interictal brain SPECT of the patients and baseline SPECT of normal control group were analyzed using automatic image registration and SPM96 softwares. The statistical analysis was performed to compare the mean SPECT image of normal group with individual ictal SPECT, and each mean image of the interictal groups of the right or left TLE with individual ictal scans. The t statistic SPM [t] was transformed to SPM [Z] with a threshold of 1.64. The statistical results were displayed and rendered on the reference 3 dimensional MRI images with P value of 0.05 and uncorrected extent threshold p value of 0.5 for SPM [Z]. SPM data demonstrated increased uptake within the epileptic lesion in 19 patients (90.4 %), among them, localized increased uptake confined to the epileptogenic lesion was seen in only 4 (19%) but 15 patients (71.4%) showed hyperperfusion within propagation sites. Bi-temporal hyperperfusion was observed in 11 out of 19 patients (57.9%, 5 in the right and 6 in the left); higher uptake within the lesion than contralateral side in 9, similar activity in 1 and higher uptake within contralateral lobe in one. Extra-temporal hyperperfusion was observed in 8 (2 in the right, 3 in the left, 3 in bilateral); unilateral hyperperfusion within the epileptogenic temporal lobe and extra-temporal area in 4, bi-temporal with extra-temporal hyperperfusion in remaining 4. Ictal brain SPECT is highly

LES MEDICAMENTS FALSIFIES, CRIME SANS CHATIMENT

Directory of Open Access Journals (Sweden)

Marc GENTILINI

2017-05-01

Full Text Available Le trafic de faux médicaments n’est pas un phénomène récent, mais un fléau qui s’aggrave. Plus mortel que le Paludisme et plus rentable que le trafic des drogues, il menace tant la santé des populations que le développement économique des pays les plus pauvres. Des anticancéreux aux traitements des dysfonctionnements érectiles, princeps ou génériques, tous les types de médicaments font l’objet de falsification. Profitant de la mondialisation des échanges et de l’essor d’Internet, ce trafic mortifère s’est développé et s’étend désormais sur les 5 continents. Considéré comme « le plus gros marché noir du monde », il reste pourtant sous-estimé, voire méconnu, du grand public, des professionnels de santé et des dirigeants politiques. La prise de conscience à tous les niveaux des risques engendrés par les médicaments falsifiés est une urgence vitale.

CONTROLE DE COHERENCE ET DE FAISABILITE DE PROJETS DANS UN SYSTEME DE C.A.O. BATIMENT

Directory of Open Access Journals (Sweden)

M BELACHIA

2001-06-01

Full Text Available Le contrôle de la cohérence et de la faisabilité est devenu une préoccupation essentielle pour les développeurs de systèmes de C.A.O, car les concepteurs et les utilisateurs ont besoin d’outils pour vérifier la validité de leur conception. Nous supposons qu’une large partie de ce contrôle est intégrée dans les modules techniques. Cependant, plus particulièrement lors de l’étude des phases précoces de conception, il s’avère indispensable d’identifier les causes des dysfonctionnements. Après une analyse des différents types d’anomalies que nous pouvons rencontrer durant le processus de conception pouvant conduire à des incohérences ou des «non faisabilité» d’un projet, nous avons déduit les méthodes appropriées pour informer les utilisateurs à bon escient. Elles sont généralement basées sur des vérifications automatiques et transparentes avec des possibilités de reports de déclenchement des contrôles.

Delirium during the course of electroconvulsive therapy in a patient on lithium carbonate treatment.

Science.gov (United States)

Sadananda, Suneetha Karkada; Narayanaswamy, Janardhanan C; Srinivasaraju, Ravindra; Math, Suresh Bada

2013-01-01

The safety of concurrent mood stabilizers during the course of electroconvulsive therapy (ECT) is yet to be clearly established. Delirium with concurrent administration of ECT and lithium carbonate is described in this case report. A 30-year-old male with a past history of significant head injury developed delirium during the course of bitemporal ECT. The clinical picture and the details of the cognitive impairment have been discussed in the report with a focus on relationship between the lithium carbonate administration and the concurrent ECT. Patients with preexisting organic brain damage could be prone to develop the cognitive adverse effect while on a combination of lithium and ECT. Possible interactions between lithium and ECT need further systematic evaluation. Copyright © 2013 Elsevier Inc. All rights reserved.

The Regularized Iteratively Reweighted MAD Method for Change Detection in Multi- and Hyperspectral Data

DEFF Research Database (Denmark)

Nielsen, Allan Aasbjerg

2007-01-01

This paper describes new extensions to the previously published multivariate alteration detection (MAD) method for change detection in bi-temporal, multi- and hypervariate data such as remote sensing imagery. Much like boosting methods often applied in data mining work, the iteratively reweighted...... to observations that show little change, i.e., for which the sum of squared, standardized MAD variates is small, and small weights are assigned to observations for which the sum is large. Like the original MAD method, the iterative extension is invariant to linear (affine) transformations of the original...... an agricultural region in Kenya, and hyperspectral airborne HyMap data from a small rural area in southeastern Germany are given. The latter case demonstrates the need for regularization....

Case of a woman with acromegaly whose presenting complaint was prolonged post-partum amenorrhea.

Science.gov (United States)

Hara, Tomomi; Kanasaki, Haruhiko; Oride, Aki; Moriyama, Masayuki; Kyo, Satoru

2016-10-01

We report a case of a woman who was incidentally diagnosed with acromegaly after referral for prolonged post-partum amenorrhea. A 25-year-old woman, gravida 2 para 1, had a normal transvaginal delivery and breastfeeding had been discontinued more than a year after delivery. Thereafter, spontaneous menstruation did not restart and she underwent hormonal therapy. Subsequently, she was referred to our university hospital for prolonged amenorrhea. Hormonal examination revealed severe hypogonadotropic hypogonadism (luteinizing hormone 0.5 mIU/mL, follicle-stimulating hormone amenorrhea, which revealed mass lesions extending from the pituitary fossa to the suprasellar area with similar signal intensity as the gray matter. In addition, bitemporal hemianopsia was observed on campimetry. After further examination, the patient was diagnosed with acromegaly. © 2016 Japan Society of Obstetrics and Gynecology.

The incidentaloma of the pituitary gland: Is neurosurgery required

Energy Technology Data Exchange (ETDEWEB)

Reincke, M.; Allolio, B.; Saeger, W.; Menzel, J.; Winkelmann, W. (Univ. of Cologne (West Germany))

1990-05-23

The authors describe a series of 18 patients with an intrasellar mass incidentally discovered by computed tomography or magnetic resonance imaging. The average size of the mass was 13 mm, with a range from 5 to 25 mm. Initial ophthalmologic examination revealed bitemporal hemianopia in 2 patients. Results of routine endocrine testing showed partial hypopituitarism in 5 patients and growth hormone hypersecretion without signs and symptoms of acromegaly in 1 patient. Four patients underwent neurosurgery. Histologically, one chondroid chordoma and three pituitary adenomas were found. In the remaining 14 patients treated conservatively, repeated computed tomography and magnetic resonance imaging revealed no significant change in tumor size at the time of follow-up. The results suggest that the incidentaloma of the pituitary gland is a benign condition that does not necessarily require neurosurgical intervention.

The incidentaloma of the pituitary gland: Is neurosurgery required?

International Nuclear Information System (INIS)

Reincke, M.; Allolio, B.; Saeger, W.; Menzel, J.; Winkelmann, W.

1990-01-01

The authors describe a series of 18 patients with an intrasellar mass incidentally discovered by computed tomography or magnetic resonance imaging. The average size of the mass was 13 mm, with a range from 5 to 25 mm. Initial ophthalmologic examination revealed bitemporal hemianopia in 2 patients. Results of routine endocrine testing showed partial hypopituitarism in 5 patients and growth hormone hypersecretion without signs and symptoms of acromegaly in 1 patient. Four patients underwent neurosurgery. Histologically, one chondroid chordoma and three pituitary adenomas were found. In the remaining 14 patients treated conservatively, repeated computed tomography and magnetic resonance imaging revealed no significant change in tumor size at the time of follow-up. The results suggest that the incidentaloma of the pituitary gland is a benign condition that does not necessarily require neurosurgical intervention

Methylphenidate modulates activity within cognitive neural networks of patients with post-stroke major depression: A placebo-controlled fMRI study

Directory of Open Access Journals (Sweden)

Rajamannar Ramasubbu

2008-10-01

Full Text Available Rajamannar Ramasubbu1, Bradley G Goodyear21Departments of Psychiatry and Clinical Neurosciences; 2Department of Radiology and Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, Calgary, AB, CanadaBackground: Methylphenidate (MP is a dopamine- and noradrenaline-enhancing agent beneficial for post-stroke depression (PSD and stroke recovery due to its therapeutic effects on cognition, motivation, and mood; however, the neural mechanisms underlying its clinical effects remain unknown. This study used functional magnetic resonance imaging (fMRI to investigate the effect of MP on brain activity in response to cognitive tasks in patients with PSD.Methods: Nine stroke outpatients with DSM IV defined major depression underwent fMRI during two cognitive tasks (2-back and serial subtraction on four occasions, on the first and third day of a three-day treatment of MP and placebo. Nine healthy control (HC subjects matched for age and sex scanned during a single session served as normative data for comparison. The main outcome measure was cognitive task-dependent brain activity.Results: For the 2-back task, left prefrontal, right parietal, posterior cingulate, and temporal and bilateral cerebellar regions exhibited significantly greater activity during the MP condition relative to placebo. Less activity was detected in rostral prefrontal and left parietal regions. For serial subtraction, greater activity was detected in medial prefrontal, biparietal, bitemporal, posterior cingulate, and bilateral cerebellar regions, as well as thalamus, putamen, and insula. Further, underactivation observed during the placebo condition relative to HC improved or reversed during MP treatment. No significant differences in behavioral measures were found between MP and placebo conditions or between patients and HC.Conclusions: Short-term MP treatment may improve and normalize activity in cognitive neuronal networks in patients with PSD

Dysfunction of the temporalis muscle after pterional craniotomy for intracranial aneurysms: comparative, prospective and randomized study of one flap versus two flaps dieresis Disfunção do músculo temporal após craniotomia pterional para tratamento de aneurismas intracranianos: estudo comparativo, prospectivo e aleatório da diérese em camada única versus camada dupla

Directory of Open Access Journals (Sweden)

FRANCISCO CARLOS DE ANDRADE JR.

1998-06-01

Full Text Available Patients with intracranial aneurysm(s of the carotid artery territory, treated with pterional craniotomy, were prospectively and randomly addressed to one layer flap (n=36 or myocutaneous (MC versus two layers' dieresis (n=32 or interfascial (IF. The study protocol included the patient's sex, age, area of craniotomy, time of flap dieresis and synthesis, time of bone dieresis and synthesis, the intracranial time, including dura mater dieresis and synthesis and time of flap retraction. Before and after surgery, the patients were evaluated with examination specially oriented to V and VII cranial nerves, bi-temporal diameter measurement, the symmetry of the temporal region, tempora-mandibularis joint (TMJ movements and cranial CT scan. The evaluations of the TMJ dysfunctions were postoperative pain, movement limitations at mastication, occlusion, mouth aperture and lateral movements of the jaw. The statistical analysis showed that the incidence of pain at TMJ and moderate and severe temporalis muscle atrophy was observed, comparing MC and IF, and there were significant differences among these ones, being greater in IF group. We concluded that both techniques permit equivalent access to the studied intracranial aneurysm(s, and the atrophy of temporalis muscle, pain and movement limitations of the temporomandibularis joint were prevalent, worse and more long-lasting in two-layers flap dieresis than in one-layer flap dieresis.Pacientes com aneurisma(s intracraniano(s foram tratados pela via pterional e de modo prospectivo e aleatório submetidos às variantes técnicas, miocutânea (MC(n=36 ou em retalho único e interfascial (IF (n=32 ou em retalho duplo. No protocolo foram anotados o sexo, idade, área da craniotomia, período de diérese e síntese do retalho, período de diérese e síntese óssea, o período do procedimento intracraniano, incluindo o tempo de diérese e síntese da dura-máter e o período de retração do retalho. Os pacientes

Females with de novo aberrations in PHF6: clinical overlap of Borjeson-Forssman-Lehmann with Coffin-Siris syndrome.

Science.gov (United States)

Zweier, Christiane; Rittinger, Olaf; Bader, Ingrid; Berland, Siren; Cole, Trevor; Degenhardt, Franziska; Di Donato, Nataliya; Graul-Neumann, Luitgard; Hoyer, Juliane; Lynch, Sally Ann; Vlasak, Ingrid; Wieczorek, Dagmar

2014-09-01

Recently, de novo aberrations in PHF6 were identified in females with intellectual disability and with a distinct phenotype including a characteristic facial gestalt with bitemporal narrowing, prominent supraorbital ridges, synophrys, a short nose and dental anomalies, tapering fingers with brachytelephalangy, clinodactyly and hypoplastic nails, short toes with hypoplastic nails, and linear skin hyperpigmentation. In adolescent or older patients, this phenotype overlaps but is not identical with Borjeson-Forssman-Lehmann syndrome in males, caused by X-linked recessive mutations in PHF6. In younger girls there seems to be a striking phenotypic overlap with Coffin-Siris syndrome, which is characterized by intellectual disability, sparse hair and hypoplastic nails. This review will summarize and characterize the female phenotype caused by de novo aberrations in PHF6 and will discuss the overlapping and distinguishing features with Coffin-Siris syndrome. © 2014 Wiley Periodicals, Inc.

Joubert syndrome presenting as unilateral dysplastic kidney, hypotonia, and respiratory problem

Directory of Open Access Journals (Sweden)

Majid Malaki

2012-01-01

Full Text Available An 8-month-old girl with a history of asphyxia and respiratory distress immediately after birth was hospitalized at her fourth month of age with the diagnosis of kidney infection and it was revealed that she had a unilateral multicystic dysplastic kidney. In recent admission, she presented to emergency room with fever, hyperpnea, and apnea. In appearance, she was a hypotonic girl with broad forehead, hypertelorism, depressed nasal bridge and bitemporal regions, rapid vertical and horizontal nystagmus, and open mouth with salivation. In spite of normal physical growth, she had delayed developmental milestones. Blood gas O 2 saturation dropped after she received phenobarbital. Her urinary and blood tests were normal; however, her cranial magnetic resonance imaging (MRI revealed vermis agenesis and molar tooth sign. These physical and para-clinical findings suggested Joubert syndrome.

A primary sellar neuroblastoma mimicking a pituitary adenoma: A case report

Energy Technology Data Exchange (ETDEWEB)

Kim, Dong Gun; Heo, Young Jin; Kim, Eun Kyoung; Baek, Jin Wook; Jeong, Hae Woong; Jung, Hyun Seok [Busan Paik Hospital, Inje University College of Medicine, Busan (Korea, Republic of)

2016-12-15

Intracranial neuroblastomas are uncommon malignant tumors that usually arise in the supratentorial parenchymal or paraventricular location. A primary neuroblastoma arising in the sella turcica is extremely rare. We report a case of a 76-year-old man who presented with progressive bitemporal hemianopsia. His pituitary hormone levels were within the normal range, except for slightly increased prolactin. Pituitary magnetic resonance imaging revealed a solitary sellar mass with supra- and parasellar extension that mimicked a non-functioning pituitary adenoma or meningioma. The tumor was excised by transsphenoidal resection. Histopathologic analysis revealed small cells surrounded by a dense fibrillary stroma as well as strong expression of neural markers. Hence, the patient was diagnosed with sellar neuroblastoma. Prolactin levels normalized in the immediate postoperative period, although visual disturbances persisted. Herein, we describe the clinical manifestations, MRI characteristics, and histopathologic findings of this case.

Sentinel-2 for rapid operational landslide inventory mapping

Science.gov (United States)

Stumpf, André; Marc, Odin; Malet, Jean-Philippe; Michea, David

2017-04-01

Landslide inventory mapping after major triggering events such as heavy rainfalls or earthquakes is crucial for disaster response, the assessment of hazards, and the quantification of sediment budgets and empirical scaling laws. Numerous studies have already demonstrated the utility of very-high resolution satellite and aerial images for the elaboration of inventories based on semi-automatic methods or visual image interpretation. Nevertheless, such semi-automatic methods are rarely used in an operational context after major triggering events; this is partly due to access limitations on the required input datasets (i.e. VHR satellite images) and to the absence of dedicated services (i.e. processing chain) available for the landslide community. Several on-going initiatives allow to overcome these limitations. First, from a data perspective, the launch of the Sentinel-2 mission offers opportunities for the design of an operational service that can be deployed for landslide inventory mapping at any time and everywhere on the globe. Second, from an implementation perspective, the Geohazards Exploitation Platform (GEP) of the European Space Agency (ESA) allows the integration and diffusion of on-line processing algorithms in a high computing performance environment. Third, from a community perspective, the recently launched Landslide Pilot of the Committee on Earth Observation Satellites (CEOS), has targeted the take-off of such service as a main objective for the landslide community. Within this context, this study targets the development of a largely automatic, supervised image processing chain for landslide inventory mapping from bi-temporal (before and after a given event) Sentinel-2 optical images. The processing chain combines change detection methods, image segmentation, higher-level image features (e.g. texture, shape) and topographic variables. Based on a few representative examples provided by a human operator, a machine learning model is trained and

Addison's Disease and Pituitary Enlargement.

Science.gov (United States)

Winters, Stephen J; Vitaz, Todd; Nowacki, Michael R; Craddock, Durrett C; Silverman, Craig

2015-06-01

A 60-year-old man with Addison's disease, primary hypothyroidism and type 2 diabetes mellitus who was treated with stable doses of hydrocortisone and fludrocortisone developed increasing skin pigmentation and a bitemporal hemianopia. The plasma ACTH level was 14,464 pg/mL, and an invasive pituitary macroadenoma with suprasellar extension was found on magnetic resonance imaging leading to transnasal-transsphenoidal adenomectomy. The tumor demonstrated features of an eosinophilic adenoma and stained uniformly for ACTH. Residual tumor was treated with stereotactic radiotherapy. This case and the 13 cases published previously indicate that primary adrenal failure may predispose to corticotroph hyperplasia, and in some patients to the development of an invasive corticotroph adenoma. The ACTH level should be measured, and a pituitary magnetic resonance imaging is indicated when skin pigmentation increases in a patient with primary adrenal failure who is receiving customary treatment with glucocorticoids and mineralocorticoids.

A Relational Encoding of a Conceptual Model with Multiple Temporal Dimensions

Science.gov (United States)

Gubiani, Donatella; Montanari, Angelo

The theoretical interest and the practical relevance of a systematic treatment of multiple temporal dimensions is widely recognized in the database and information system communities. Nevertheless, most relational databases have no temporal support at all. A few of them provide a limited support, in terms of temporal data types and predicates, constructors, and functions for the management of time values (borrowed from the SQL standard). One (resp., two) temporal dimensions are supported by historical and transaction-time (resp., bitemporal) databases only. In this paper, we provide a relational encoding of a conceptual model featuring four temporal dimensions, namely, the classical valid and transaction times, plus the event and availability times. We focus our attention on the distinctive technical features of the proposed temporal extension of the relation model. In the last part of the paper, we briefly show how to implement it in a standard DBMS.

Genetic Alzheimer Disease and Sporadic Dementia With Lewy Bodies: A Comorbidity Presenting as Primary Progressive Aphasia.

Science.gov (United States)

Picková, Tereza; Matěj, Radoslav; Bezdicek, Ondrej; Keller, Jiří; van der Zee, Julie; Van Broeckhoven, Christine; Cséfalvay, Zsolt; Rusina, Robert

2017-03-01

We report a 44-year-old woman, with a family history of early-onset dementia, presenting with primary progressive aphasia. This clinically variable syndrome has multiple underlying pathologies, and correlations between clinical manifestations and postmortem neuropathologic findings are controversial. Our patient suffered worsening language impairment with major word-finding difficulties but preserved comprehension. She also developed episodic memory impairment. Her condition progressed to dementia with behavioral changes. Magnetic resonance imaging showed early left perisylvian and bitemporal atrophy. The patient died shortly afterward from colon cancer. Neuropathologic examination revealed advanced early-onset Alzheimer and Lewy body disease, plus a clinically nonrelevant metastasis of her colon cancer in her left parietal lobe. Genetic examination revealed a p.Glu184Asp mutation in the presenilin1 gene. Our findings confirm the importance of a thorough appreciation for the clinical and neuropathologic correlations in patients with atypical neurodegenerative dementias.

Cerebral scintigraphy by {sup 99m}Tc-HMPAO in sleep apnea syndromes (SAS) during the wakeful state; Scintigraphie cerebrale au Tc99m-HMPAO dans les syndromes d`apnees du sommeil (SAS) pendant l`etat de veille

Energy Technology Data Exchange (ETDEWEB)

Tainturier, C.; Benamor, M.; Hausser-Hauw, C.; Rakotonanahary, D.; Fleury, B. [CMC FOCH 92150 SURESNES (France)

1997-12-31

The SAS is associated to cerebral hemodynamic modifications and to a high frequency of cerebro-vascular accidents. The aim of this study was to verify, during wakeful state, the cerebral hemodynamic in 14 patients afflicted with SAS of various intensity (Apnea Index = 5-120/h). 555 MBq of {sup 99m}Tc-HMPAO were injected in patients maintained awake. The images were obtained 20 minutes after injection by mean of a double-head chamber equipped with fan-beam collimators. They were interpreted visually by two independent readers. Anomalies of cerebral fixation were observed in 12/14 patients. They were small sores of diffuse hypo-fixations, with a `riddly` aspect (4 cases), sores of bi-temporal hypo-fixation with a right- or left- hemispheric predominance (6 cases), or right fronto-temporal hypo-fixations (2 cases). The cerebral fixation anomalies were reported in the SASs. Ficker et al (1997) have shown in-sleep frontal hypo-perfusions in 5/14 apneic patients, reversible under continuous positive airing pressure (CPAP). In conclusion, anomalies of cerebral fixation exist in SAS-carrying patients, even in the wakeful state. Questions about hypoperfusion, pre-lacunar syndrome, atrophy still remain. A check of this study is planned after the CPAP treatment to determine the hemodynamic or anatomic origin and the anomaly reversibility

Cerebral scintigraphy by 99mTc-HMPAO in sleep apnea syndromes (SAS) during the wakeful state

International Nuclear Information System (INIS)

Tainturier, C.; Benamor, M.; Hausser-Hauw, C.; Rakotonanahary, D.; Fleury, B.

1997-01-01

The SAS is associated to cerebral hemodynamic modifications and to a high frequency of cerebro-vascular accidents. The aim of this study was to verify, during wakeful state, the cerebral hemodynamic in 14 patients afflicted with SAS of various intensity (Apnea Index = 5-120/h). 555 MBq of 99m Tc-HMPAO were injected in patients maintained awake. The images were obtained 20 minutes after injection by mean of a double-head chamber equipped with fan-beam collimators. They were interpreted visually by two independent readers. Anomalies of cerebral fixation were observed in 12/14 patients. They were small sores of diffuse hypo-fixations, with a 'riddly' aspect (4 cases), sores of bi-temporal hypo-fixation with a right- or left- hemispheric predominance (6 cases), or right fronto-temporal hypo-fixations (2 cases). The cerebral fixation anomalies were reported in the SASs. Ficker et al (1997) have shown in-sleep frontal hypo-perfusions in 5/14 apneic patients, reversible under continuous positive airing pressure (CPAP). In conclusion, anomalies of cerebral fixation exist in SAS-carrying patients, even in the wakeful state. Questions about hypoperfusion, pre-lacunar syndrome, atrophy still remain. A check of this study is planned after the CPAP treatment to determine the hemodynamic or anatomic origin and the anomaly reversibility

Retrospective chart review of elderly patients receiving electroconvulsive therapy in a tertiary general hospital

Directory of Open Access Journals (Sweden)

Mosam Phirke

2015-01-01

Full Text Available Background: Electroconvulsive therapy (ECT is the one of the oldest and effective treatments in psychiatry today. It has been used in a wide variety of psychiatric disorders in both young and old patients. Aims of the study: The present study is a retrospective chart review of geriatric patients receiving ECT as a treatment option in a tertiary care general hospital psychiatry setting. Methodology: The study evaluated ECT records over a 5-year period between the years 2010 and 2014, and it was observed that 23 elderly patients (aged ≥60 years had received ECT. Results: The patients received modified bitemporal ECT using a brief pulse ECT machine and had no major complications. A total of 184 ECT treatments were administered at an average of 8 treatments per case. The major diagnoses of patients were schizophrenia and major depression. The main indications of ECT were intolerance to medication, suicidal behavior and aggression. Out of the 23 elderly patients, 18 (78.26% showed a good response to ECT. The only complication noted was memory loss and confusion in 3 cases. Patients with medical illnesses like hypertension, diabetes and both together received ECT without any complications. Conclusions: This study adds to the scarce database on the use of ECT in elderly patients in India and adds evidence to the fact that ECT is a safe and effective treatment in the elderly.

Plan d'assurance qualité (PAQ) un outil de partenariat

CERN Document Server

Pasquali, J

1998-01-01

En matière d'assurance qualité, la formalisation du système qualité est nécessaire pour démontrer la conformité par rapport au modèle (ex : ISO 9001, 9002 ou 9003). Dans ce cadre, certains contractants mettent en place un plan d'assurance qualité PAQ destiné à contenir les dispositions spécifiques à l'exécution de leur contrat avec le CERN. Si le PAQ, outil du système qualité du contractant, régit la relation « ST-contractant », il n'en demeure pas moins qu'une définition précise de « ce que l'on veut » s'avère indispensable. L'assurance qualité est censée garantir la régularité de la qualité pour obtenir la confiance des clients et réduire les coûts par la réduction des contrôles et des dysfonctionnements. Cela suppose qu'en amont, la parfaite prise en compte des besoins du client final de la part de « ST »soit assurée. Cela le sera d'autant plus et mieux, qu'avec la démarche "Qualité", ST pourra pleinement se concentrer sur son rôle de conseiller, d'expert technique et...

Catherine Parayre, « Les impostures de l’écriture : “Comment réussir sa vie” de Paul Savoie et La critique de Céline Forcier

Directory of Open Access Journals (Sweden)

Catherine Parayre

2016-12-01

Full Text Available En soi, les calculs secrets de tout imposteur ont pour objectif de manipuler autrui et de le convaincre à croire vrai ce qui ne l’est pas. Dans la nouvelle « Comment réussir sa vie » de Paul Savoie (L’empire des rôdeurs, 2004 tout autant que dans le roman La critique (2012 de Céline Forcier, l’imposture consiste chez le protagoniste à s’arroger le rôle d’écrivain sans toutefois se soumettre à la critique, c’est-à-dire à publier un texte en passant outre les règles du monde de l’édition. Savoie et Forcier dressent ainsi le portrait complexe, ni approbateur ni antipathique, d’auteurs isolés mais opiniâtres. Dans une critique sous-jacente, ils n’épargnent pas non plus les excès et autres dysfonctionnements de l’institution littéraire. Au-delà de destins particuliers, « Comment réussir sa vie » et La critique se font surtout l’écho de questions et thèmes volontiers abordés dans l’écriture en milieu minoritaire. L’article entreprend de déterminer dans quelle mesure ces deux textes explorent diverses facettes de la figure de l’écrivain franco-ontarien.

Mixing geometric and radiometric features for change classification

Science.gov (United States)

Fournier, Alexandre; Descombes, Xavier; Zerubia, Josiane

2008-02-01

Most basic change detection algorithms use a pixel-based approach. Whereas such approach is quite well defined for monitoring important area changes (such as urban growth monitoring) in low resolution images, an object based approach seems more relevant when the change detection is specifically aimed toward targets (such as small buildings and vehicles). In this paper, we present an approach that mixes radiometric and geometric features to qualify the changed zones. The goal is to establish bounds (appearance, disappearance, substitution ...) between the detected changes and the underlying objects. We proceed by first clustering the change map (containing each pixel bitemporal radiosity) in different classes using the entropy-kmeans algorithm. Assuming that most man-made objects have a polygonal shape, a polygonal approximation algorithm is then used in order to characterize the resulting zone shapes. Hence allowing us to refine the primary rough classification, by integrating the polygon orientations in the state space. Tests are currently conducted on Quickbird data.

Sellar Chordoma Presenting as Pseudo-macroprolactinoma with Unilateral Third Cranial Nerve Palsy

Institute of Scientific and Technical Information of China (English)

Hai-feng Wang; Hong-xi Ma; Cheng-yuan Ma; Yi-nan Luo; Peng-fei Ge

2012-01-01

We described a 61-year-old female with a sellar chordoma,which presented as pseudo-macroprolactinoma with unilateral third cranial nerve palsy.Physical examination revealed that her right upper lid could not be raised by itself,right eyeball movement limited to the abduction direction,right pupil dilated to 4.5 mm with negative reaction to light,and hemianopsia in bitemporal sides.CT scanning showed a hyperdense lesion at sellar region without bone destruction.Magnetic resonance imaging (MRI) revealed the tumor was 2.3 cm×1.8 cm×2.6 cm,with iso-intensity on T1WI,hyper-intensity on T2WI and heterogeneous enhancement on contrast imaging.Endocrine examination showed her serum prolactin level increased to 1,031.49 mlU/ml.The tumor was sub-totally resected via pterional craniotomy under microscope and was histologically proven to be a chordoma.Postoperatively,she recovered uneventfully but ptosis and hemianopsia remained at the 6th month.

A case report of clival tuberculoma

International Nuclear Information System (INIS)

Ichikawa, Fumihiko; Tachibana, Shigekuni; Miyasaka, Yoshio; Suwa, Tomoya; Iida, Hideo; Kan, Shinichi; Matsuda, Yukimasa

1987-01-01

A patient with tuberculoma at the skull base was reported. Twenty-two years old, she had complained for ten years of amenorrhea, headache, and visual disturbance. On neurological examination, bitemporal hemianopsia, bilateral sixth nerve palsy, and recent right-side facial palsy were demonstrated. On radiological examination, a destructive lesion was found at the clivus. CT and MRI demonstrated, a space-taking lesion expanding to the floor of the third ventricle anteriorly, to the cerebello-pontine angle superiorly, and to the epipharynx inferiorly, and a marked swelling of the cerebellum, though no confirmative diagnosis could be obtained without a biopsy of the epipharyngeal tumor. The histological examination revealed that the tumor was tuberculoma. Medical treatment with INH, RFP, and steroids was effective. Although tuberculoma involving the skull base is very rare and rather difficult to diagnose, the authors would like to stress that early accurate diagnosis is very important because the lesion is curable with appropriate medical treatment. (author)

Case report of clival tuberculoma. Difficult to diagnose by means of a CT scan

Energy Technology Data Exchange (ETDEWEB)

Ichikawa, F.; Tachibana, S.; Miyasaka, Y.; Suwa, T.; Iida, H.; Kan, S.; Matsuda, Y.

1987-02-01

A patient with tuberculoma at the skull base was reported. Twenty-two years old, she had complained for ten years of amenorrhea, headache, and visual disturbance. On neurological examination, bitemporal hemianopsia, bilateral sixth nerve palsy, and recent right-side facial palsy were demonstrated. On radiological examination, a destructive lesion was found at the clivus. CT and MRI demonstrated, a space-taking lesion expanding to the floor of the third ventricle anteriorly, to the cerebello-pontine angle superiorly, and to the epipharynx inferiorly, and a marked swelling of the cerebellum, though no confirmative diagnosis could be obtained without a biopsy of the epipharyngeal tumor. The histological examination revealed that the tumor was tuberculoma. Medical treatment with INH, RFP, and steroids was effective. Although tuberculoma involving the skull base is very rare and rather difficult to diagnose, the authors would like to stress that early accurate diagnosis is very important because the lesion is curable with appropriate medical treatment.

Clinical and Hormonal Characteristics of Patients with Giant Masses of Sellar-Chiasmatic Region

Directory of Open Access Journals (Sweden)

K.B. Alimova

2016-05-01

Full Text Available Objective: to study the clinical and hormonal characteristics of patients with giant masses of sellar-chiasmatic area. Material and methods. During the period from 2015 to 2016, we have examined 35 adult patients with pituitary macroadenomas, including 48.6 % of men. The average age of men was 37.12 years, women — 38.15 years. The disease duration ranged from 2 months to 25 years. Results. Distribution of patients according to topographic and anatomical classification of pituitary adenoma side growth showed that pituitary adenomas with total growth were (51.4 % most frequent. Patients with giant pituitary adenomas most often had panhypopituitarism (44.4 %, as well as bitemporal hemianopsia (61.1 % and secondary amenorrhea (33.3 %. Such disorders, as a secondary osteopenia, endocrine encephalopathy, delayed physical and sexual development, had been identified only in this group of patients. In addition, a significant decrease in the mean values of basal levels of tropic pituitary hormones (growth hormone (GH, luteinizing hormone (LH, follicle stimulating hormone (FSH, adrenocorticotropic hormone was observed in patients with giant pituitary adenomas. Conclusions. Patients with giant pituitary adenomas have primarily a decrease in GH, FSH, LH levels. The most significant neuroendocrine and ophthalmic disorders occur in patients with giant pituitary adenomas.

Liver and water metabolism; Foie et metabolisme de l'eau

Energy Technology Data Exchange (ETDEWEB)

Fallot, P. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Faculte des Sciences de Grenoble, 38 (France)

1959-07-01

The causes for the disturbance of hydro-electrolytic equilibrium observed in cirrhosis patients are far from clear. Studies on the static distribution of liquid in the organism and also on anomalies in the distribution of deuterium oxide and tritiated water provide no direct explanation of the nature of the water retaining mechanism. At the period when the illness is established, endocrine factors and electrolytic perturbations contribute to maintaining or increasing oliguresis, but they cannot be held solely responsible in the initial stages of evolution. An explanation of the ascites should therefore be looked for in a non-functioning of the polygonal or Kupffer cells. The hypothesis of an insufficient rejection of water outside the lymph spaces of the liver during cirrhosis is put forward, but the experimental demonstration of such a phenomenon proves very difficult. (author) [French] Les causes du desequilibre hydroelectrolytique observe chez les malades cirrhotiques sont loin d'etre elucidees. Les etudes de la repartition du liquide de l'organisme ainsi que celles des anomalies de la distribution de l'oxyde de deuterium et de l'eau tritiee n'apportent aucune explication directe sur la nature du mecanisme de la retention de l'eau. A la periode d'etat de la maladie, les facteurs endocriniens et les perturbations electrolytiques contribuent a entretenir ou a accroitre l'oligurie mais ils ne peuvent etre seuls invoques lors des stades initiaux de l'evolution. Il faudrait donc rechercher dans un dysfonctionnement des cellules polygonales ou kupfferiennes l'explication de l'ascite. L'hypothese d'une insuffisance du rejet de l'eau hors des espaces lymphatiques du foie au cours de la cirrhose est evoquee mais la demonstration d'un tel phenomene s'avere tres difficile sur le plan experimental. (auteur)

Liver and water metabolism; Foie et metabolisme de l'eau

Energy Technology Data Exchange (ETDEWEB)

Fallot, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Faculte des Sciences de Grenoble, 38 (France)

1959-07-01

The causes for the disturbance of hydro-electrolytic equilibrium observed in cirrhosis patients are far from clear. Studies on the static distribution of liquid in the organism and also on anomalies in the distribution of deuterium oxide and tritiated water provide no direct explanation of the nature of the water retaining mechanism. At the period when the illness is established, endocrine factors and electrolytic perturbations contribute to maintaining or increasing oliguresis, but they cannot be held solely responsible in the initial stages of evolution. An explanation of the ascites should therefore be looked for in a non-functioning of the polygonal or Kupffer cells. The hypothesis of an insufficient rejection of water outside the lymph spaces of the liver during cirrhosis is put forward, but the experimental demonstration of such a phenomenon proves very difficult. (author) [French] Les causes du desequilibre hydroelectrolytique observe chez les malades cirrhotiques sont loin d'etre elucidees. Les etudes de la repartition du liquide de l'organisme ainsi que celles des anomalies de la distribution de l'oxyde de deuterium et de l'eau tritiee n'apportent aucune explication directe sur la nature du mecanisme de la retention de l'eau. A la periode d'etat de la maladie, les facteurs endocriniens et les perturbations electrolytiques contribuent a entretenir ou a accroitre l'oligurie mais ils ne peuvent etre seuls invoques lors des stades initiaux de l'evolution. Il faudrait donc rechercher dans un dysfonctionnement des cellules polygonales ou kupfferiennes l'explication de l'ascite. L'hypothese d'une insuffisance du rejet de l'eau hors des espaces lymphatiques du foie au cours de la cirrhose est evoquee mais la demonstration d'un tel phenomene s'avere tres difficile sur le plan experimental. (auteur)

Effets du statut d’emploi sur la santé et la sécurité au travail : le cas des auxiliaires familiales et sociales et des infirmières de soins à domicile au Québec

Directory of Open Access Journals (Sweden)

Élise Ledoux

2005-05-01

Full Text Available Les données de cette recherche corroborent les principaux résultats de nombreuses études sur les liens entre la précarité d’emploi et les risques accrus à la santé et à la sécurité du travail (SST. Constituée de quatre études de cas de services de soutien à domicile (SAD de Centres locaux de services communautaires (CLSC, cette recherche montre comment l’organisation du travail peut soutenir les stratégies protectrices auxquelles ont recours les auxiliaires sociales et familiales (AFS et les infirmières de services de SAD ou leur nuire. Il s’avère que les pratiques organisationnelles positives auraient les mêmes effets sur les salariées régulières que sur celles qui ont un statut précaire, cependant ces dernières bénéficient rarement de ce soutien. Quant aux dysfonctionnements organisationnels, les personnels précaires disposent de moins de marges de manœuvre pour les pallier. Ils sont donc doublement à risque au regard de leur santé et de leur sécurité au travail.The data from this study corroborate the main results of many studies on the relationships between job precariousness and increased occupational health and safety (OHS risks. This project consists of four studies of cases of local community service centre (CLSC homecare services (HS and shows how work organization can have a positive or negative effect on the protective strategies used by HS homecare workers and nurses. Positive organizational practices would have the same effects on regular employees as on those with a precarious status; however, the latter rarely benefit from this support. As for organizational dysfunction, precarious employees have less margin of maneuver to compensate for it. They therefore face a two-fold greater occupational health and safety risk.

Infrared imaging and spectral-domain optical coherence tomography findings correlate with microperimetry in acute macular neuroretinopathy: a case report

Directory of Open Access Journals (Sweden)

Grover Sandeep

2011-10-01

Full Text Available Abstract Introduction Spectral-domain optical coherence tomography findings in a patient with acute macular neuroretinopathy, and correlation with functional defects on microperimetry, are presented. Case presentation A 25-year old Caucasian woman presented with bitemporal field defects following an upper respiratory tract infection. Her visual acuity was 20/20 in both eyes and a dilated fundus examination revealed bilateral hyperpigmentary changes in the papillomacular bundle. Our patient underwent further evaluation with spectral-domain optical coherence tomography, infrared and fundus autofluorescence imaging. Functional changes were assessed by microperimetry. Infrared imaging showed the classic wedge-shaped defects and spectral-domain optical coherence tomography exhibited changes at the inner segment-outer segment junction, with a thickened outer plexiform layer overlying these areas. Fluorescein and indocyanine green angiography did not demonstrate any perfusion defects or any other abnormality. Microperimetry demonstrated focal elevation in threshold correlating with the wedge-shaped defects in both eyes. Conclusion Spectral-domain optical coherence tomography findings provide new evidence of the involvement of the outer plexiform layer of the retina in acute macular neuroretinopathy.

Neuroimaging characteristics and growth pattern on magnetic resonance imaging in a 52-year-old man presenting with pituicytoma: a case report

Directory of Open Access Journals (Sweden)

Kosuge Yasushi

2012-09-01

Full Text Available Abstract Introduction Pituicytoma is a rare neoplasm of the neurohypophysis. To the best of our knowledge there have been no reports of pituicytoma in which long-term magnetic resonance imaging observation was performed. We calculated the doubling time of the tumor volume and described the growth pattern of a pituicytoma. Case presentation A 52-year-old Japanese man with a history of decreased libido was found to have a sellar and suprasellar mass. He underwent transsphenoidal surgery, but only a small specimen was obtained because of intraoperative bleeding. The tentative histological diagnosis was schwannoma. He noticed bitemporal hemianopsia 7 years later. A follow-up magnetic resonance imaging disclosed a tumor volume doubling time of 3830 days. Transcranial gross-total tumor resection was performed. The lesion consisted of elongated and plump tumor cells that were arranged in a fascicular or storiform pattern and were positive for S-100 protein and focally positive for glial fibrillary acidic protein. The final histological diagnosis was pituicytoma. Conclusion Pituicytoma is a slow-growing tumor, but the growth rate may change during follow-up.

Reproducibility and Practical Adoption of GEOBIA with Open-Source Software in Docker Containers

Directory of Open Access Journals (Sweden)

Christian Knoth

2017-03-01

Full Text Available Geographic Object-Based Image Analysis (GEOBIA mostly uses proprietary software,but the interest in Free and Open-Source Software (FOSS for GEOBIA is growing. This interest stems not only from cost savings, but also from benefits concerning reproducibility and collaboration. Technical challenges hamper practical reproducibility, especially when multiple software packages are required to conduct an analysis. In this study, we use containerization to package a GEOBIA workflow in a well-defined FOSS environment. We explore the approach using two software stacks to perform an exemplary analysis detecting destruction of buildings in bi-temporal images of a conflict area. The analysis combines feature extraction techniques with segmentation and object-based analysis to detect changes using automatically-defined local reference values and to distinguish disappeared buildings from non-target structures. The resulting workflow is published as FOSS comprising both the model and data in a ready to use Docker image and a user interface for interaction with the containerized workflow. The presented solution advances GEOBIA in the following aspects: higher transparency of methodology; easier reuse and adaption of workflows; better transferability between operating systems; complete description of the software environment; and easy application of workflows by image analysis experts and non-experts. As a result, it promotes not only the reproducibility of GEOBIA, but also its practical adoption.

Continued-fraction representation of the Kraus map for non-Markovian reservoir damping

Science.gov (United States)

van Wonderen, A. J.; Suttorp, L. G.

2018-04-01

Quantum dissipation is studied for a discrete system that linearly interacts with a reservoir of harmonic oscillators at thermal equilibrium. Initial correlations between system and reservoir are assumed to be absent. The dissipative dynamics as determined by the unitary evolution of system and reservoir is described by a Kraus map consisting of an infinite number of matrices. For all Laplace-transformed Kraus matrices exact solutions are constructed in terms of continued fractions that depend on the pair correlation functions of the reservoir. By performing factorizations in the Kraus map a perturbation theory is set up that conserves in arbitrary perturbative order both positivity and probability of the density matrix. The latter is determined by an integral equation for a bitemporal matrix and a finite hierarchy for Kraus matrices. In the lowest perturbative order this hierarchy reduces to one equation for one Kraus matrix. Its solution is given by a continued fraction of a much simpler structure as compared to the non-perturbative case. In the lowest perturbative order our non-Markovian evolution equations are applied to the damped Jaynes–Cummings model. From the solution for the atomic density matrix it is found that the atom may remain in the state of maximum entropy for a significant time span that depends on the initial energy of the radiation field.

Dominant mutations in KAT6A cause intellectual disability with recognizable syndromic features.

Science.gov (United States)

Tham, Emma; Lindstrand, Anna; Santani, Avni; Malmgren, Helena; Nesbitt, Addie; Dubbs, Holly A; Zackai, Elaine H; Parker, Michael J; Millan, Francisca; Rosenbaum, Kenneth; Wilson, Golder N; Nordgren, Ann

2015-03-05

Through a multi-center collaboration study, we here report six individuals from five unrelated families, with mutations in KAT6A/MOZ detected by whole-exome sequencing. All five different de novo heterozygous truncating mutations were located in the C-terminal transactivation domain of KAT6A: NM_001099412.1: c.3116_3117 delCT, p.(Ser1039∗); c.3830_3831insTT, p.(Arg1278Serfs∗17); c.3879 dupA, p.(Glu1294Argfs∗19); c.4108G>T p.(Glu1370∗) and c.4292 dupT, p.(Leu1431Phefs∗8). An additional subject with a 0.23 MB microdeletion including the entire KAT6A reading frame was identified with genome-wide array comparative genomic hybridization. Finally, by detailed clinical characterization we provide evidence that heterozygous mutations in KAT6A cause a distinct intellectual disability syndrome. The common phenotype includes hypotonia, intellectual disability, early feeding and oromotor difficulties, microcephaly and/or craniosynostosis, and cardiac defects in combination with subtle facial features such as bitemporal narrowing, broad nasal tip, thin upper lip, posteriorly rotated or low-set ears, and microretrognathia. The identification of human subjects complements previous work from mice and zebrafish where knockouts of Kat6a/kat6a lead to developmental defects. Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

Analysis of Water Resources in Horqin Sandy Land Using Multisource Data from 2003 to 2010

Directory of Open Access Journals (Sweden)

Zhenzhen Zhao

2016-04-01

Full Text Available Over the past four decades, land use/land cover (LU/LC change, coupled with persistent drought, has resulted in the decline of groundwater levels in Horqin Sandy Land. Accordingly, this study quantifies changes in LU/LC and groundwater storage (GWS. Furthermore, it investigates the effects of LU/LC changes on GWS. GWS changes are estimated using Gravity Recovery and Climate Experiment (GRACE data and ground-based measurements obtained from July 2003 to December 2010. Soil moisture and snow water equivalent data derived from the Global Land Data Assimilation System (GLDAS are used to isolate GWS changes from GRACE-derived terrestrial water storage changes. The result shows that the groundwater depletion rate in Horqin Sandy Land is 13.5 ± 1.9 mm·year−1 in 2003–2010, which is consistent with the results of monitoring well stations. LU/LC changes are detected using bitemporal imageries (2003 and 2010 from Landsat Thematic Mapper through the post-classification comparison method. The result shows that LU/LC significantly changed during the aforementioned period. Bare soil and built-up land have increased by 76.6% and 82.2%, respectively, while cropland, vegetation, and water bodies have decreased by 14.1%, 74.5%, and 82.6%, respectively. The analysis of GWS and LU/LC changes shows that LU/LC changes and persistent drought are the main factors that affect groundwater resources.

Impact of Recent Hardware and Software Trends on High Performance Transaction Processing and Analytics

Science.gov (United States)

Mohan, C.

In this paper, I survey briefly some of the recent and emerging trends in hardware and software features which impact high performance transaction processing and data analytics applications. These features include multicore processor chips, ultra large main memories, flash storage, storage class memories, database appliances, field programmable gate arrays, transactional memory, key-value stores, and cloud computing. While some applications, e.g., Web 2.0 ones, were initially built without traditional transaction processing functionality in mind, slowly system architects and designers are beginning to address such previously ignored issues. The availability, analytics and response time requirements of these applications were initially given more importance than ACID transaction semantics and resource consumption characteristics. A project at IBM Almaden is studying the implications of phase change memory on transaction processing, in the context of a key-value store. Bitemporal data management has also become an important requirement, especially for financial applications. Power consumption and heat dissipation properties are also major considerations in the emergence of modern software and hardware architectural features. Considerations relating to ease of configuration, installation, maintenance and monitoring, and improvement of total cost of ownership have resulted in database appliances becoming very popular. The MapReduce paradigm is now quite popular for large scale data analysis, in spite of the major inefficiencies associated with it.

An unusual chiasmal visual defect in a patient with neuromyelitis optica: case report Comprometimento quiasmático incomum em um paciente com neuromielite óptica: relato de caso

Directory of Open Access Journals (Sweden)

Roberta Martins da Silva Costa

2007-02-01

Full Text Available PURPOSE: To report the unusual visual field finding due to a chiasmal neuritis in a 33-year-old female with the diagnosis of optic neuromyelitis optica (Devic's syndrome. METHODS: We report a case of a 33 years old female with limb paraesthesias, weakness in the legs, bowel and bladder dysfunction that was referred to the "Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo" in October 1995. Six years and four months later she had an acute visual involvement. Ophthalmologic examination, laboratory studies, magnetic resonance imaging (MRI and a 24-2 threshold visual field in the Humphrey field analyzer were performed. RESULTS: The MRI scan showed enlargement and cavitation on the spinal cord and chiasmal involvement (thickening of the chiasm with contrast enhancement and no demyelinating lesions in the brain, brainstem, or cerebellum. The central 24-degree threshold field examination showed an inferior visual field defect bitemporally, disclosing a chiasmal involvement. CONCLUSION: Chiasmal involvement may occur in neuromyelitis optica, probably due to a plaque within the chiasm. The authors call attention to the importance of visual field examination with particular regard to quantifying the visual impairment and follow-up of these patients.OBJETIVO: Relatar o caso de uma mulher de 33 anos de idade, com o diagnóstico de neuromielite óptica (síndrome de Devic acometendo o quiasma óptico que apresentou um escotoma incomum no exame de campo visual. MÉTODOS: Uma paciente do sexo feminino, portadora de parestesias nos membros inferiores, fraqueza nas pernas, disfunção da defecação e disfunção urinária, foi encaminhada para o Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo em outubro do ano de 1995. Seis anos e quatro meses mais tarde ela sofreu acometimento visual agudo. Foram realizados exame oftalmológico completo, exame de líquor, resson

Child dermoid cyst mimicking a craniopharyngioma: the benefit of MRI T2-weighted diffusion sequence.

Science.gov (United States)

Amelot, Aymeric; Borha, Alin; Calmon, Raphael; Barbet, Patrick; Puget, Stephanie

2018-02-01

Brain dermoid cysts are very rare lesions. Although benign, these cysts may be associated with devastating complications due to mass effect or meningitis. The discovery of completely asymptomatic dermoid cysts in the pediatric population is exceedingly rare. Despite the advances in imaging modalities, it sometimes remains difficult to exclude the differential diagnosis of craniopharyngioma. We describe a 12-year-old boy addressed for suspicion of craniopharyngioma diagnosed by decreased visual acuity, bitemporal hemianopia and a CT scan showing a large hypodense suprasellar lesion with intralesional calcifications. Despite the unusual localization and size of this lesion, the absence of dermal sinus commonly found, and before visualizing a hyperintense mass on MRI-diffusion, the diagnosis of craniopharyngioma was ruled out in favor of a dermoid cyst. Radical excision was performed. In the suprasellar area, craniopharyngioma and dermoid cyst may have very similar radiological aspects: low density masses on CT scan and a hyperintense signal on T1-weighted MRI sequences with a variable signal on T2-weighted sequences. Hitherto, only two cases in literature have described suprasellar dermoid cyst. Their initial diagnosis was facilitated by the presence of a dermal sinus.

Quand tout ne tient qu’à un pont ! Réfection d’ouvrage et dysfonctionnements urbains à Douala Rehabilitation of a bridge and urban dysfunctioning in Douala

Directory of Open Access Journals (Sweden)

Didier Plat

2012-12-01

Full Text Available Les travaux de réhabilitation du pont sur le fleuve Wouri, à Douala, ont nécessité la restriction de la circulation d’une partie des transports collectifs urbains. Pour compenser la diminution de l’offre de transport, un service payant de navette pour la seule traversée du pont a été institué. Les mesures de circulation adoptées sans prévision des effets potentiels ont mis à jour des incohérences dans le fonctionnement institutionnel et ont rajouté des contraintes fortes aux usagers des transports collectifs. Un événement exceptionnel met ainsi en lumière le caractère névralgique des grands équipements de transport dans le fonctionnement des systèmes urbains africains.Rehabilitation work of the bridge on the Wouri river, in Douala, required the restriction of vehicle traffic, particularly taxis and motorbike taxis. To compensate for the reduction in public transport provision, a paying bus service for the crossing of the bridge was set up. The traffic restriction, imposed without forecasting side effects, revealed inconsistencies in institutional functioning and added on strong constraints to public transport users. Such an exceptional event shows evidence of the key role of large transport facilities in the functioning of African urban systems.

[Possibilities of transcranial magnetic therapy and color and rhythm therapy in rehabilitation of ischemic stroke].

Science.gov (United States)

Sholomov, I I; Cherevashchenko, L A; Suprunov, O V; Raĭgorondskiĭ, Iu M

2009-01-01

One hundred and sixteen post-stroke patients were studied in the early rehabilitation period. All patients were divided into 4 groups: 3 main and 1 control groups. Three main groups (87 patients) received transcranial magnetic therapy (TMT) and/or color and rhythm therapy (CRT) along with traditional treatment and the control group (29 patients) received only basic therapy. TMT was conducted using bitemporal technique, running regime with modulation frequency 1-10 Hz. In CRT, the alternating stimulation of the right and left eye with green and/or blue color with a period of 2-4 s and duration of luminescence 1s was applied. Each of 3 main groups received 2 treatment sessions with an interval of 1,5 month (1st - TMT, 2nd - CRT, 3rd - TMT + CRT). After the treatment, the marked positive changes were seen in all main groups, in particular in group 3. The improvement of neurologic symptoms on the B. Lindmark scale was higher by 9,5% in group 3 compared to the control one, on the Barthel index - by 8,8%, on MMSE and A. Luria and Schulte test - by 5,4 and 14,3%, respectively. Rheographic and encephalographic study revealed the significant improvement of hemodynamics and alpha-rhythm differentiation, decrease of patients with dysrhythmia by 14,6% in group 3 as compared to the control group. The best results were seen in the combination of TMT and CRT, TMT exerted a higher effect on the hemodynamics and CRT - on the psychoemotional state. Both therapies were well tolerated and had no side-effects.

LES PROLIFÉRATIONS VÉGÉTALES AQUATIQUES EN FRANCE :CARACTÈRES BIOLOGIQUES ET ÉCOLOGIQUES DES PRINCIPALESESPÈCES ET MILIEUX PROPICES.II. IMPACT SUR LES ÉCOSYSTÈMES ET INTÉRÊT POUR LECONTRÔLE DES PROLIFÉRATIONS.

Directory of Open Access Journals (Sweden)

PELTRE M. C.

2002-04-01

Full Text Available De nombreux milieux aquatiques de nature et d’usages divers sont plus ou moins régulièrement le siège de proliférations végétales. Le contrôle de celles-ci pose des difficultés, principalement liées à l’appréciation des déséquilibres induits dans le milieu et à celle des nuisances anthropiques qui en découlent. En effet, dans le cas d’un constat de prolifération, source et témoin d’un dysfonctionnement, le manque d’analyse objective des situations, les limites de compatibilité des différents usages du milieu, la mauvaise connaissance des végétaux en cause et du fonctionnement écologique des milieux sont autant de freins à une gestion cohérente de ces sites. La présentation de quelques exemples, à travers différents modes connus de gestion des milieux et de régulation des peuplements végétaux (notamment les méthodes mécaniques, chimiques ou biologiques, illustre la mise à profit des connaissances sur les caractéristiques biologiques et écologiques des macrophytes proliférants. La mise en Oeuvre de cette démarche devrait permettre à l’avenir de mieux évaluer les perturbations induites par les proliférations, d’intervenir si nécessaire dans de meilleures conditions, en vue d’envisager une restauration des écosystèmes concernés compatible avec une meilleure satisfaction des différents usages.

Correlation between displacement of optic chiasm on MR and visual symptomas and signs

International Nuclear Information System (INIS)

Kang, Eun Joo; Jang, Yun Hyung; Baik, Seung Kug; Ahn, Woo Hyun; Choi, Han Yong; Kim, Bong Gi

1994-01-01

MR is the most useful imaging method in evaluating the anatomic changes of the optic chiasm (OC). The purpose of this study is to investigate the relationship between the OC displacement and visual manifestations. We retrospectively reviewed 44 patients who showed displacement of OC on brain MR. The pattern of OC displacement was classified into 3 groups according to following criteria: group A included the patients with OC displacement only due to empty sella; group B represented the patients with OC displacement by a lesion and the border between the lesion and OC was distinct; and group C was the patients with OC displacement by a lesion and had a indistinct border or thinning of the OC. Visual symptoms and signs were noted in 12 patients and the most common sign was bitemporal hemianopsia. In group A (7 patients), the visual symptoms and signs were seen in only one patient (14%), in whom contracted visual fields persisted since previous pituitary apoplexy had developed. In group B (30 patients), the visual symptoms and signs were seen in 4 patients (13%) who had tumorous conditions except one case of cysticercosis. In group C (7 patients), the visual symptoms and signs were seen in all patients (100%). The more OC is compressed, the more the prevalence of visual symptoms and signs increases. However, there was no correlation between the occurrence of visual symptoms and the presence of OC displacement only without compression

Spatial Pattern of Populus euphratica Forest Change as Affected by Water Conveyance in the Lower Tarim River

Directory of Open Access Journals (Sweden)

Shuhong Peng

2014-01-01

Full Text Available To restore declining species, including Populus euphratica and other riparian communities, in the river ecosystem of the lower Tarim River, the ecological water conveyance project (EWCP, as a part of an integrated water resource management plan, was implemented in 2000. The EWCP aims to schedule and manage the water resources in the upper reaches and transfer water to the lower reaches by a series of intermittent water deliveries. The delivered water flows along a modified river channel and nourishes riparian communities by river overflow flooding. Since it began, it has caused a fierce debate over the response of riparian vegetation to the water conveyance scheme. This study focuses on the lower Tarim River, where Populus euphratica forests have undergone watering, due to the EWCP. Twelve Landsat sensor images and one IKONOS satellite imagery acquired between 1999 and 2009 were used to monitor the change in Populus euphratica forests. Bi-temporal change detection and temporal trajectory analysis were employed to represent the spatial pattern of the forest change. Field investigations were used to analyze the driving forces behind forest change from the perspectives of anthropogenic activities and natural forces. The results showed that Populus euphratica forest have been declining in area, which implies that ecological risks have been increased during the watering process. However, forests areas have increased in the regions where the water supply is abundant, and vice versa.

PET imaging in temporal lobe epilepsy

International Nuclear Information System (INIS)

Semah, F.

2006-01-01

The research projects on epilepsy addressed two main issues: the pathophysiology of the inter-ictal hypo-metabolism in temporal lobe epilepsy and the role of the basal ganglia in the control of seizure. Our research projects focused primarily on temporal lobe epilepsy: The pathophysiology of inter-ictal hypo-metabolism and its correlation with the epileptogenic network was investigated in patients with mesial temporal lobe epilepsy. Inter-ictal hypo-metabolism is commonly found in mesio-temporal lobe epilepsy (MTLE) but its pathophysiology remains incompletely understood. We hypothesized that metabolic changes reflect the preferential networks involved in ictal discharges. We analyzed the topography of inter-ictal hypo-metabolism according to electro-clinical patterns in 50 patients with unilateral hippocampal sclerosis (HS) and consistent features of MTLE. Based on electro-clinical correlations we identified 4 groups:1) mesial group characterized by mesial seizure onset without evidence of early spread beyond the temporal lobe; 2) anterior mesio-lateral group (AML) with early anterior spread, involving the anterior lateral temporal cortex and insulo-fronto-opercular areas; 3) widespread mesio-lateral group (WML) with widespread spread, involving both anterior and posterior lateral temporal and peri-sylvian areas; 4) bi-temporal group (BT) with early contralateral temporal spread. Results of FDG-PET imaging in each group were compared to control subjects using statistical parametric mapping software (SPM99). MRI data and surgical outcome in each group were compared to metabolic findings. Hypo-metabolism was limited to the hippocampal gyrus, the temporal pole and the insula in the mesial group. Gradual involvement of the lateral temporal cortex, the insula and the peri-sylvian areas was observed in the AML and WML groups. The BT group differed from the others by mild bi-temporal involvement, bilateral insular hypo-metabolism and longer epilepsy duration. MRI

PET imaging in temporal lobe epilepsy

Energy Technology Data Exchange (ETDEWEB)

Semah, F. [Service Hospitalier Frederic Joliot, DSV-CEA, 91 Orsay (France)

2006-07-01

The research projects on epilepsy addressed two main issues: the pathophysiology of the inter-ictal hypo-metabolism in temporal lobe epilepsy and the role of the basal ganglia in the control of seizure. Our research projects focused primarily on temporal lobe epilepsy: The pathophysiology of inter-ictal hypo-metabolism and its correlation with the epileptogenic network was investigated in patients with mesial temporal lobe epilepsy. Inter-ictal hypo-metabolism is commonly found in mesio-temporal lobe epilepsy (MTLE) but its pathophysiology remains incompletely understood. We hypothesized that metabolic changes reflect the preferential networks involved in ictal discharges. We analyzed the topography of inter-ictal hypo-metabolism according to electro-clinical patterns in 50 patients with unilateral hippocampal sclerosis (HS) and consistent features of MTLE. Based on electro-clinical correlations we identified 4 groups:1) mesial group characterized by mesial seizure onset without evidence of early spread beyond the temporal lobe; 2) anterior mesio-lateral group (AML) with early anterior spread, involving the anterior lateral temporal cortex and insulo-fronto-opercular areas; 3) widespread mesio-lateral group (WML) with widespread spread, involving both anterior and posterior lateral temporal and peri-sylvian areas; 4) bi-temporal group (BT) with early contralateral temporal spread. Results of FDG-PET imaging in each group were compared to control subjects using statistical parametric mapping software (SPM99). MRI data and surgical outcome in each group were compared to metabolic findings. Hypo-metabolism was limited to the hippocampal gyrus, the temporal pole and the insula in the mesial group. Gradual involvement of the lateral temporal cortex, the insula and the peri-sylvian areas was observed in the AML and WML groups. The BT group differed from the others by mild bi-temporal involvement, bilateral insular hypo-metabolism and longer epilepsy duration. MRI

AN APPROACH TO ALLEVIATE THE FALSE ALARM IN BUILDING CHANGE DETECTION FROM URBAN VHR IMAGE

Directory of Open Access Journals (Sweden)

J. Chen

2016-06-01

Full Text Available Building change detection from very-high-resolution (VHR urban remote sensing image frequently encounter the challenge of serious false alarm caused by different illumination or viewing angles in bi-temporal images. An approach to alleviate the false alarm in urban building change detection is proposed in this paper. Firstly, as shadows casted by urban buildings are of distinct spectral and shape feature, it adopts a supervised object-based classification technique to extract them in this paper. Secondly, on the opposite direction of sunlight illumination, a straight line is drawn along the principal orientation of building in every extracted shadow region. Starting from the straight line and moving toward the sunlight direction, a rectangular area is constructed to cover partial shadow and rooftop of each building. Thirdly, an algebra and geometry invariant based method is used to abstract the spatial topological relationship of the potential unchanged buildings from all central points of the rectangular area. Finally, based on an oriented texture curvature descriptor, an index is established to determine the actual false alarm in building change detection result. The experiment results validate that the proposed method can be used as an effective framework to alleviate the false alarm in building change detection from urban VHR image.

Extended endoscopic endonasal surgery using three-dimensional endoscopy in the intra-operative MRI suite for supra-diaphragmatic ectopic pituitary adenoma.

Science.gov (United States)

Fuminari, Komatsu; Hideki, Atsumi; Manabu, Osakabe; Mitsunori, Matsumae

2015-01-01

We describe a supra-diaphragmatic ectopic pituitary adenoma that was safely removed using the extended endoscopic endonasal approach, and discuss the value of three-dimensional (3D) endoscopy and intra-operative magnetic resonance imaging (MRI) to this type of procedure. A 61-year-old-man with bitemporal hemianopsia was referred to our hospital, where MRI revealed an enhanced suprasellar tumor compressing the optic chiasma. The tumor extended on the planum sphenoidale and partially encased the right internal carotid artery. An endocrinological assessment indicated normal pituitary function. The extended endoscopic endonasal approach was taken using a 3D endoscope in the intraoperative MRI suite. The tumor was located above the diaphragma sellae and separated from the normal pituitary gland. The pathological findings indicated non-functioning pituitary adenoma and thus the tumor was diagnosed as a supra-diaphragmatic ectopic pituitary adenoma. Intra-operative MRI provided useful information to minimize dural opening and the supra-diaphragmatic ectopic pituitary adenoma was removed from the complex neurovascular structure via the extended endoscopic endonasal approach under 3D endoscopic guidance in the intra-operative suite. Safe and effective removal of a supra-diaphragmatic ectopic pituitary adenoma was accomplished via the extended endoscopic endonasal approach with visual information provided by 3D endoscopy and intra-operative MRI.

Convolutional neural network features based change detection in satellite images

Science.gov (United States)

Mohammed El Amin, Arabi; Liu, Qingjie; Wang, Yunhong

2016-07-01

With the popular use of high resolution remote sensing (HRRS) satellite images, a huge research efforts have been placed on change detection (CD) problem. An effective feature selection method can significantly boost the final result. While hand-designed features have proven difficulties to design features that effectively capture high and mid-level representations, the recent developments in machine learning (Deep Learning) omit this problem by learning hierarchical representation in an unsupervised manner directly from data without human intervention. In this letter, we propose approaching the change detection problem from a feature learning perspective. A novel deep Convolutional Neural Networks (CNN) features based HR satellite images change detection method is proposed. The main guideline is to produce a change detection map directly from two images using a pretrained CNN. This method can omit the limited performance of hand-crafted features. Firstly, CNN features are extracted through different convolutional layers. Then, a concatenation step is evaluated after an normalization step, resulting in a unique higher dimensional feature map. Finally, a change map was computed using pixel-wise Euclidean distance. Our method has been validated on real bitemporal HRRS satellite images according to qualitative and quantitative analyses. The results obtained confirm the interest of the proposed method.

Craniofacial and dental development in Costello syndrome.

Science.gov (United States)

Goodwin, Alice F; Oberoi, Snehlata; Landan, Maya; Charles, Cyril; Massie, Jessica C; Fairley, Cecilia; Rauen, Katherine A; Klein, Ophir D

2014-06-01

Costello syndrome (CS) is a RASopathy characterized by a wide range of cardiac, musculoskeletal, dermatological, and developmental abnormalities. The RASopathies are defined as a group of syndromes caused by activated Ras/mitogen-activated protein kinase (MAPK) signaling. Specifically, CS is caused by activating mutations in HRAS. Although receptor tyrosine kinase (RTK) signaling, which is upstream of Ras/MAPK, is known to play a critical role in craniofacial and dental development, the craniofacial and dental features of CS have not been systematically defined in a large group of individuals. In order to address this gap in our understanding and fully characterize the CS phenotype, we evaluated the craniofacial and dental phenotype in a large cohort (n = 41) of CS individuals. We confirmed that the craniofacial features common in CS include macrocephaly, bitemporal narrowing, convex facial profile, full cheeks, and large mouth. Additionally, CS patients have a characteristic dental phenotype that includes malocclusion with anterior open bite and posterior crossbite, enamel hypo-mineralization, delayed tooth development and eruption, gingival hyperplasia, thickening of the alveolar ridge, and high palate. Comparison of the craniofacial and dental phenotype in CS with other RASopathies, such as cardio-facio-cutaneous syndrome (CFC), provides insight into the complexities of Ras/MAPK signaling in human craniofacial and dental development. © 2014 Wiley Periodicals, Inc.

Distinct phenotype of PHF6 deletions in females.

Science.gov (United States)

Di Donato, N; Isidor, B; Lopez Cazaux, S; Le Caignec, C; Klink, B; Kraus, C; Schrock, E; Hackmann, K

2014-02-01

We report on two female patients carrying small overlapping Xq26.2 deletions of 100 kb and 270 kb involving the PHF6 gene. Mutations in PHF6 have been reported in individuals with Borjeson-Forssman-Lehmann syndrome, a condition present almost exclusively in males. Two very recent papers revealed de novo PHF6 defects in seven female patients with intellectual disability and a phenotype resembling Coffin-Siris syndrome (sparse hair, bitemporal narrowing, arched eyebrows, synophrys, high nasal root, bulbous nasal tip, marked clinodactyly with the hypoplastic terminal phalanges of the fifth fingers and cutaneous syndactyly of the toes, Blaschkoid linear skin hyperpigmentation, dental anomalies and occasional major malformations). The clinical presentation of these patients overlaps completely with our first patient, who carries a germline deletion involving PHF6. The second patient has a mosaic deletion and presented with a very mild phenotype of PHF6 loss in females. Our report confirms that PHF6 loss in females results in a recognizable phenotype overlapping with Coffin-Siris syndrome and distinct from Borjeson-Forssman-Lehmann syndrome. We expand the clinical spectrum and provide the first summary of the recommended medical evaluation. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

A Lifelong Smoker with Hypopituitarism: Rethinking the Hypothesis of a Tumor in the Hypophysis

Directory of Open Access Journals (Sweden)

Nestoras Mathioudakis

2012-01-01

Full Text Available Pituitary adenomas are the most common cause of a sellar mass. Metastases to the pituitary gland, a rare occurrence, may mimic benign pituitary adenomas. We report here a case of a 61-year-old woman with an 80-pack-year smoking history who presented with headache and diplopia. Visual field testing demonstrated bitemporal hemianopsia. Pituitary MRI revealed a 2.0 cm sellar mass impinging upon the optic chiasm. Hypopituitarism was present, with no evidence of diabetes insipidus. The patient was referred to our service for transsphenoidal resection of a presumed pituitary macroadenoma. As part of her preoperative evaluation, a chest radiograph was obtained, which showed a large hilar mass. In light of the patient’s extensive smoking history, the differential diagnosis was expanded to include metastatic lesion to the sella. Transsphenoidal resection of the tumor was performed and histopathology revealed small cell carcinoma. The patient received chemotherapy, but died 18 months later due to widespread brain metastases. Although the presence of diabetes insipidus may help to discriminate between pituitary adenomas and metastatic lesions, this is not a sensitive finding. This case illustrates the need for maintaining a high index of suspicion for pituitary metastasis in patients with known risk factors for malignancy.

Thrombasthénie de Glanzmann: à propos de 11 cas

Science.gov (United States)

Mukendi, Jean-Louis Ntumba; Benkirane, Souad; Masrar, Azlarab

2015-01-01

Introduction La thrombasthénie de Glanzmann est une pathologie hémorragique héréditaire rare due à une déficience ou un dysfonctionnement du complexe glycoprotéique IIb/IIIa de la membrane plaquettaire. Le but de notre étude est de décrire les caractéristiques démographiques, cliniques et biologiques d'une série de patients atteints de thrombasthénie de Glanzmann. Méthodes C'est une étude portant sur tous les patients atteints de thrombasthénie de Glanzmann diagnostiqués au Laboratoire Central d'Hématologie du Centre Hospitalier Ibn Sina de Rabat au Maroc pendant la période allant du 1er mars 2011 au 31 mars 2013, soit 25 mois. Après avoir recueilli les données épidémiologiques et cliniques de nos patients, nous avons réalisé une étude biologique comportant une numération plaquettaire et une agrégométrie. Résultats 11 patients ont présenté des profils agrégométriques compatibles à une TG. La majorité de ces malades étaient issus de mariages consanguins (54,5%) et originaires de régions situées dans le nord du Maroc. Le syndrome hémorragique s'est révélé principalement cutanéo-muqueux, avec une prédominance des gingivorragies (72,7%), des épistaxis (63,6%) et des ecchymoses (45,5%). Conclusion Nos résultats ont montré que la thrombasthénie de Glanzmann est une pathologie relativement fréquente au Maroc. PMID:26587119

Oméga 3 et neurotransmission cérébrale

Directory of Open Access Journals (Sweden)

Vancassel Sylvie

2004-01-01

Full Text Available Les acides gras polyinsaturés (AGPI sont des constituants structuraux fondamentaux du système nerveux central (SNC dont la teneur conditionne le fonctionnement des cellules neuronales. Ils sont des acteurs de la communication intercellulaire, notamment à travers les processus de neurotransmission. De nombreuses études ont montré chez l’animal que le déficit des membranes cérébrales en oméga 3, et plus particulièrement en acide docosahexaénoïque (22 : 6ω-3 ou DHA induit par une carence alimentaire spécifique en cette famille d’AGPI, s’accompagne de troubles de l’apprentissage. Un support neurochimique a été avancé, impliquant les processus de libération de neurotransmetteurs, notamment les monoamines et l’acétylcholine. Cette relation entre AGPI ω3 et neurotransmission est d’autant plus intéressante qu’elle pourrait être également impliquée chez l’Homme dans l’apparition et\\\\ou la sévérité de certains troubles neuropsychiatriques dans lesquels des dysfonctionnements de la neurotransmission sont constatés (schizophrénie, dépression, hyperactivité chez l’enfant. En effet, de nombreuses études révèlent un déficit du statut corporel en AGPI oméga 3 (20 : 5 et 22 : 6 mais aussi en oméga 6, qui peut être corrigé par voie nutritionnelle, permettant alors de réduire significativement certains des symptômes pathologiques. Dans ce contexte, nous développons au laboratoire des recherches visant à comprendre les mécanismes d’action des oméga 3, et en particulier du DHA, dans les membranes nerveuses et l’incidence sur le fonctionnement de ces cellules.

SAR-based change detection using hypothesis testing and Markov random field modelling

Science.gov (United States)

Cao, W.; Martinis, S.

2015-04-01

The objective of this study is to automatically detect changed areas caused by natural disasters from bi-temporal co-registered and calibrated TerraSAR-X data. The technique in this paper consists of two steps: Firstly, an automatic coarse detection step is applied based on a statistical hypothesis test for initializing the classification. The original analytical formula as proposed in the constant false alarm rate (CFAR) edge detector is reviewed and rewritten in a compact form of the incomplete beta function, which is a builtin routine in commercial scientific software such as MATLAB and IDL. Secondly, a post-classification step is introduced to optimize the noisy classification result in the previous step. Generally, an optimization problem can be formulated as a Markov random field (MRF) on which the quality of a classification is measured by an energy function. The optimal classification based on the MRF is related to the lowest energy value. Previous studies provide methods for the optimization problem using MRFs, such as the iterated conditional modes (ICM) algorithm. Recently, a novel algorithm was presented based on graph-cut theory. This method transforms a MRF to an equivalent graph and solves the optimization problem by a max-flow/min-cut algorithm on the graph. In this study this graph-cut algorithm is applied iteratively to improve the coarse classification. At each iteration the parameters of the energy function for the current classification are set by the logarithmic probability density function (PDF). The relevant parameters are estimated by the method of logarithmic cumulants (MoLC). Experiments are performed using two flood events in Germany and Australia in 2011 and a forest fire on La Palma in 2009 using pre- and post-event TerraSAR-X data. The results show convincing coarse classifications and considerable improvement by the graph-cut post-classification step.

Successful treatment of acute autoimmune limbic encephalitis with negative VGKC and NMDAR antibodies.

Science.gov (United States)

Modoni, Anna; Masciullo, Marcella; Spinelli, Pietro; Marra, Camillo; Tartaglione, Tommaso; Andreetta, Francesca; Tonali, Pietro; Silvestri, Gabriella

2009-03-01

To describe a case of acute nonherpetic limbic encephalitis (LE) with negative testing for antibodies directed against onconeuronal and cell membrane antigens, including voltage-gated potassium channels and N-methyl-D-aspartate receptor, that showed a dramatic response to immune therapy. A 30-year-old woman manifested generalized seizures, altered consciousness, and memory impairment shortly after a prodromal viral illness. Few days later the patient developed a drug-resistant epileptic status. Electroencephalograph showed bitemporal slowing and paroxysmal slow wave bursts. Brain magnetic resonance imaging showed bilateral swelling in the medial temporal lobes. Cerebrospinal fluid analysis ruled out viral etiologies. A diagnostic search for cancer, including serum testing for known onconeuronal antibodies proved negative. Screening for cell membrane antigen antibodies, including voltage-gated potassium channels and N-methyl-D-aspartate receptor, was also negative. Suspecting an autoimmune etiology, we started an immunomodulatory treatment with intravenous immunoglobulin followed by a short course of oral prednisone, obtaining a full clinical recovery. Our report confirms previous observations of "seronegative" autoimmune LE, suggesting the presence of other, still unknown central nervous system antigens representing a target of a postinfectious, autoimmune response in these patients. Moreover, it emphasizes the importance of early recognition and treatment of acute autoimmune LE, to reduce the risk of intensive care unit-related complications and the occurrence of permanent cognitive or behavioral defects.

Predicting Retrograde Autobiographical Memory Changes Following Electroconvulsive Therapy: Relationships between Individual, Treatment, and Early Clinical Factors.

Science.gov (United States)

Martin, Donel M; Gálvez, Verònica; Loo, Colleen K

2015-06-19

Loss of personal memories experienced prior to receiving electroconvulsive therapy is common and distressing and in some patients can persist for many months following treatment. Improved understanding of the relationships between individual patient factors, electroconvulsive therapy treatment factors, and clinical indicators measured early in the electroconvulsive therapy course may help clinicians minimize these side effects through better management of the electroconvulsive therapy treatment approach. In this study we examined the associations between the above factors for predicting retrograde autobiographical memory changes following electroconvulsive therapy. Seventy-four depressed participants with major depressive disorder were administered electroconvulsive therapy 3 times per week using either a right unilateral or bitemporal electrode placement and brief or ultrabrief pulse width. Verbal fluency and retrograde autobiographical memory (assessed using the Columbia Autobiographical Memory Interview - Short Form) were tested at baseline and after the last electroconvulsive therapy treatment. Time to reorientation was measured immediately following the third and sixth electroconvulsive therapy treatments. Results confirmed the utility of measuring time to reorientation early during the electroconvulsive therapy treatment course as a predictor of greater retrograde amnesia and the importance of assessing baseline cognitive status for identifying patients at greater risk for developing later side effects. With increased number of electroconvulsive therapy treatments, older age was associated with increased time to reorientation. Consistency of verbal fluency performance was moderately correlated with change in Columbia Autobiographical Memory Interview - Short Form scores following right unilateral electroconvulsive therapy. Electroconvulsive therapy treatment techniques associated with lesser cognitive side effects should be particularly considered for

Antidepressant Effects of Electroconvulsive Therapy Correlate With Subgenual Anterior Cingulate Activity and Connectivity in Depression

Science.gov (United States)

Liu, Yi; Du, Lian; Li, Yongmei; Liu, Haixia; Zhao, Wenjing; Liu, Dan; Zeng, Jinkun; Li, Xingbao; Fu, Yixiao; Qiu, Haitang; Li, Xirong; Qiu, Tian; Hu, Hua; Meng, Huaqing; Luo, Qinghua

2015-01-01

Abstract The mechanisms underlying the effects of electroconvulsive therapy (ECT) in major depressive disorder (MDD) are not fully understood. Resting-state functional magnetic resonance imaging (rs-fMRI) is a new tool to study the effects of brain stimulation interventions, particularly ECT. The authors aim to investigate the mechanisms of ECT in MDD by rs-fMRI. They used rs-fMRI to measure functional changes in the brain of first-episode, treatment-naive MDD patients (n = 23) immediately before and then following 8 ECT sessions (brief-pulse square-wave apparatus, bitemporal). They also computed voxel-wise amplitude of low-frequency fluctuation (ALFF) as a measure of regional brain activity and selected the left subgenual anterior cingulate cortex (sgACC) to evaluate functional connectivity between the sgACC and other brain regions. Increased regional brain activity measured by ALFF mainly in the left sgACC following ECT. Functional connectivity of the left sgACC increased in the ipsilateral parahippocampal gyrus, pregenual ACC, contralateral middle temporal pole, and orbitofrontal cortex. Importantly, reduction in depressive symptoms were negatively correlated with increased ALFF in the left sgACC and left hippocampus, and with distant functional connectivity between the left sgACC and contralateral middle temporal pole. That is, across subjects, as depression improved, regional brain activity in sgACC and its functional connectivity increased in the brain. Eight ECT sessions in MDD patients modulated activity in the sgACC and its networks. The antidepressant effects of ECT were negatively correlated with sgACC brain activity and connectivity. These findings suggest that sgACC-associated prefrontal-limbic structures are associated with the therapeutic effects of ECT in MDD. PMID:26559309

Neuro-ophthalmic and clinical characteristics of brain tumours in a tertiary hospital in Ghana

International Nuclear Information System (INIS)

Tagoe, N. N.; Essuman, V. A.; Fordjuor, G.; Akpalu, J.; Bankah, P.; Ndanu, T.

2015-01-01

Anecdotally, increasing number of patients are seen at Korle Bu Teaching Hospital (KBTH) with brain tumour. Neuro-ophthalmic symptoms and signs may help in timely diagnosis and intervention. The objective of this study is to evaluate the neuro-ophthalmic and clinical characteristics of brain tumour in patients presenting at a tertiary hospital in Ghana. The study design involved a prospective case series involving 36 consecutive patients newly diagnosed with brain tumour from November 2010 to October 2011, at the Ophthalmology, Neurosurgery and Endocrine units of KBTH, Ghana. All patients had clinical diagnosis of brain tumour with confirmation by computerized tomography (CT) or magnetic resonance imaging (MRI). Thirteen patients had histological confirmation of diagnosis. The outcome measures of the study include presenting visual acuity, colour vision, visual fields and cranial nerve deficits. Data of 36 patients were analysed. The results of the study showed that ages ranged from 3 to 69 years, mean (SD) 42.56(±16.6 years). Twenty-six (72%) were females. Tumours included pituitary adenoma (20, 55.5%), meningioma (10, 27.8%), choroid plexus tumour (1, 2.8%), medulloblastom (1, 2.8%), craniopharyngioma (1, 2.8%), haemangioblastoma (1, 2.8%), thalamic tumour (1, 2.8%) and haemangioma (1, 2.8%). Histologically confirmed tumours included pituitary adenoma (9, 69.2%), meningioma (3, 23.1%), craniopharyngioma (1, 7.7%). One patient had both a pituitary adenoma and meningioma. Blurred vision (30, 83.3%), headache (28, 77.8%) and photophobia (13, 36.1%) were predominant symptoms. Commonest neuro-ophthalmic signs were impaired colour vision (62 eyes, 88.6%), optic atrophy (26, 74.3%), unilateral or bitemporal hemianopia (15, 41.5%) and relative afferent pupillary defect (12, 34.3%). Seven (19.4%) patients were visually impaired and nine (25%) blind. Thirty-three of 72(45.8%) eyes had monocular blindness. Common neuro-ophthalmic characteristics were blurred vision

Change detection in a time series of polarimetric SAR data by an omnibus test statistic and its factorization (Conference Presentation)

Science.gov (United States)

Nielsen, Allan A.; Conradsen, Knut; Skriver, Henning

2016-10-01

Test statistics for comparison of real (as opposed to complex) variance-covariance matrices exist in the statistics literature [1]. In earlier publications we have described a test statistic for the equality of two variance-covariance matrices following the complex Wishart distribution with an associated p-value [2]. We showed their application to bitemporal change detection and to edge detection [3] in multilook, polarimetric synthetic aperture radar (SAR) data in the covariance matrix representation [4]. The test statistic and the associated p-value is described in [5] also. In [6] we focussed on the block-diagonal case, we elaborated on some computer implementation issues, and we gave examples on the application to change detection in both full and dual polarization bitemporal, bifrequency, multilook SAR data. In [7] we described an omnibus test statistic Q for the equality of k variance-covariance matrices following the complex Wishart distribution. We also described a factorization of Q = R2 R3 … Rk where Q and Rj determine if and when a difference occurs. Additionally, we gave p-values for Q and Rj. Finally, we demonstrated the use of Q and Rj and the p-values to change detection in truly multitemporal, full polarization SAR data. Here we illustrate the methods by means of airborne L-band SAR data (EMISAR) [8,9]. The methods may be applied to other polarimetric SAR data also such as data from Sentinel-1, COSMO-SkyMed, TerraSAR-X, ALOS, and RadarSat-2 and also to single-pol data. The account given here closely follows that given our recent IEEE TGRS paper [7]. Selected References [1] Anderson, T. W., An Introduction to Multivariate Statistical Analysis, John Wiley, New York, third ed. (2003). [2] Conradsen, K., Nielsen, A. A., Schou, J., and Skriver, H., "A test statistic in the complex Wishart distribution and its application to change detection in polarimetric SAR data," IEEE Transactions on Geoscience and Remote Sensing 41(1): 4-19, 2003. [3] Schou, J

Preliminary experience of a three-dimensional, large-field-of-view PET scanner for the localization of partial epilepsy

International Nuclear Information System (INIS)

Binns, D.S.; O'Brien, T.J.; Murphy, M.; Cook, M.J.; Hicks, R.J.

1999-01-01

Full text: PET scanning is a useful ancillary technique in the localization of intractable partial epilepsy, but its widespread use has been limited by the high cost of traditional PET equipment and radioisotopes. The use of 3D-scanning mode with a large-field of-view PET scanner involves lower equipment costs and requires significantly lower doses of radioisotope. Our aim was to report our preliminary experience of the use of a 3-D, large-field-of-view scanner for FDG-PET studies in the localization of partial epilepsy. 31 patients (pts) with partial epilepsy were studied. The FDG-PET scans were reviewed blindly by a single reviewer without knowledge of seizure localization on structural imaging or ictal electroencephalographic (EEG) monitoring. The PET results were correlated with the localization by more traditional techniques and the results on surgery when available. A localized region of hypometabolism on FDG-PET scanning was reported in 26/31 (84%) patients (21 temporal, 5 extratemporal). This compared favourably with volumetric MRI on which 19/31 (61%) had a focal potentially epileptogenic abnormality, all of which were concordant with the PET localization. PET was concordant with ictal EEG onset in all 22 patients with localizing studies, including 5 pts with normal MRI. PET demonstrated localized hypometabolism in 4/5 pts with non-localizing ictal EEG and was concordant in both pts with abnormal MRI in this group. PET was considered normal in 4 pts, including 3 pts with normal MRI but localizing EEG and 1 pt without EEG or MRI abnormality. One pt with a localizing EEG and normal MRI was felt to have bitemporal hypometabolism. Five patients have subsequently had resective epilepsy surgery with 4 currently seizure-free and 1 significantly improved. Four patients are planned for surgery in the near future. In conclusion, FDG-PET using a 3-D, large-field-of view PET scanner provides sensitive and specific localization in partial epilepsy, and may provide a

Efficacité de la gestion de vaccins et qualité de vaccination à l'antenne PEV Kisangani en République Démocratique du Congo

Science.gov (United States)

Labama, Matthieu Betofe; Longembe, Eugène Basandja; Likwela, Joris Losimba

2017-01-01

Introduction La qualité des vaccins conditionne les résultats attendus de la vaccination. Elle est tributaire de l'efficacité de système de gestion technique et logistique mis en place. Cette étude est menée pour évaluer l'efficacité de la gestion des vaccins et d'en tirer des leçons. Méthodes Une étude rétrospective est menée pendant la période de 2010 à 2014 sur la gestion logistique de vaccins au niveau de l'antenne PEV Kisangani. La revue documentaire complétée par les entretiens semi-dirigés des gestionnaires et prestataires de services de vaccination ont permis d'évaluer la gestion de vaccins en se servant des modèle GEV de l'OMS, en vue de dégager les écarts. Résultats Il est observé une faible connaissance des prestataires sur les vaccins qui ne peuvent pas être congelés, sur les tests de congélation et d'autres dommages de vaccins. La gestion informatisée des données au niveau de l'antenne est correctement assurée. Aucun critère évalué n'a atteint l'objectif de 80%. Le respect de la température de stockage est de 70% au niveau de l'antenne ; le critère relatif à la gestion de vaccins est respectivement de 65% et 67% au niveau du BCZ et CS. Le critère relatif à la maintenance est nul à tous les niveaux. Conclusion Le dysfonctionnement de système logistique est remarquable à tous les niveaux de la pyramide sanitaire, ceci pourrait interférer avec la qualité et l'impact attendu de la vaccination. Une attention particulière doit être accordée à la maintenance des équipements. PMID:28748006

Les paysages périurbains montagnards à la croisée des regards des sciences écologiques et des sciences socio-économiques

Directory of Open Access Journals (Sweden)

Nathalie Bertrand

2009-06-01

Full Text Available Les mutations des paysages régionaux dues aux pressions urbaines questionnent l’usage du sol. Elles interpellent à la fois des enjeux économiques, sociaux et environnementaux voire spatiaux sous-tendus par l’étalement urbain, l’accroissement des déplacements domicile-travail, le mitage de l’espace. Ces évolutions et dysfonctionnements renvoient à la question de la durabilité du développement des régions, et particulièrement des Alpes, espace contraint géographiquement et objet de nombreuses pressions anthropiques et riche en biotopes remarquables. Cet article est basé sur deux ans de travaux menés par des socio-économistes et des écologues sur les effets sur le paysage et l’environnement de la périurbanisation d’un massif alpin. Nous avons pris en compte l’espace dans les processus environnementaux, économiques ou sociaux. Intrinsèque dans les analyses écologiques, elle a longtemps posé problème à l’économie pour intégrer l’espace comme dimension à part entière des processus économiques. Trois thèmes sont ici développés : l’approche du point de vue du paysage, les problèmes d’échelles spatiales et temporelles, le choix d’indicateurs. Ils demandent de hiérarchiser les questions et de pratiquer le travail en commun. Aller au-delà nécessite de développer une interrogation plus écologique ou plus économique et/ou sociale en quittant de ce fait l’interface pour favoriser des interrogations disciplinaires particulières.Changes in regional landscapes due to urban pressures raise questions regarding land use. They also give rise to economic, social and environmental issues related to urban sprawl, increases in daily commuting, and land consumption. These changes and dysfunctions are ultimately underpinned by the question of sustainable regional development. Mountain regions such as the Alps, with their various outstanding biotopes in a restricted space, are particularly vulnerable.

Periurban landscapes in mountain areas

Directory of Open Access Journals (Sweden)

Nathalie Bertrand

2009-06-01

Full Text Available Les mutations des paysages régionaux dues aux pressions urbaines questionnent l’usage du sol. Elles interpellent à la fois des enjeux économiques, sociaux et environnementaux voire spatiaux sous-tendus par l’étalement urbain, l’accroissement des déplacements domicile-travail, le mitage de l’espace. Ces évolutions et dysfonctionnements renvoient à la question de la durabilité du développement des régions, et particulièrement des Alpes, espace contraint géographiquement et objet de nombreuses pressions anthropiques et riche en biotopes remarquables. Cet article est basé sur deux ans de travaux menés par des socio-économistes et des écologues sur les effets sur le paysage et l’environnement de la périurbanisation d’un massif alpin. Nous avons pris en compte l’espace dans les processus environnementaux, économiques ou sociaux. Intrinsèque dans les analyses écologiques, elle a longtemps posé problème à l’économie pour intégrer l’espace comme dimension à part entière des processus économiques. Trois thèmes sont ici développés : l’approche du point de vue du paysage, les problèmes d’échelles spatiales et temporelles, le choix d’indicateurs. Ils demandent de hiérarchiser les questions et de pratiquer le travail en commun. Aller au-delà nécessite de développer une interrogation plus écologique ou plus économique et/ou sociale en quittant de ce fait l’interface pour favoriser des interrogations disciplinaires particulières.Changes in regional landscapes due to urban pressures raise questions regarding land use. They also give rise to economic, social and environmental issues related to urban sprawl, increases in daily commuting, and land consumption. These changes and dysfunctions are ultimately underpinned by the question of sustainable regional development. Mountain regions such as the Alps, with their various outstanding biotopes in a restricted space, are particularly vulnerable.

Les effets neurocognitifs de la vitamine D chez la personne âgée

Directory of Open Access Journals (Sweden)

Annweiler Cédric

2014-05-01

Full Text Available Une alimentation saine, en particulier la consommation régulière d’aliments riches en vitamine D, est un facteur protecteur contre la survenue de pathologie démentielle chez la personne âgée. Outre ses propriétés traditionnellement reconnues de régulation du métabolisme phosphocalcique, la vitamine D est une hormone neurostéroïde indispensable au fonctionnement neurophysiologique (régulation de neurotransmetteurs et de neurotrophines avec, en plus, une action neuroprotectrice anti-inflammatoire et anti-oxydante. Au contraire son insuffisance, extrêmement prévalente chez la personne âgée, pourrait engendrer des dysfonctionnements du système nerveux central, expliquant en partie les troubles cognitifs rencontrés dans cette population. L’épidémiologie est cohérente avec cette notion et rapporte une association entre hypovitaminose D et trouble cognitif, que ce soit en population âgée générale ou chez le malade Alzheimer. Les essais d’intervention confirment la relation de causalité et quantifient l’efficacité cognitive de la supplémentation vitaminique D chez la personne âgée, ce qui suscite des perspectives en matière de prévention primo-secondaire des troubles cognitifs chez la personne âgée par un apport exogène de vitamine D. En particulier, tandis que les traitements anti-démence symptomatiques actuellement disponibles ne font que ralentir transitoirement le déclin cognitif, les futures possibilités de traitement pourraient reposer sur des combinaisons médicamenteuses luttant contre plusieurs mécanismes neurodégénératifs à la fois. À ce titre, la vitamine D améliore l’efficacité de la mémantine en termes de protection neuronale et de prévention du déclin cognitif au cours de la maladie d’Alzheimer.

Seizure semiology identifies patients with bilateral temporal lobe epilepsy.

Science.gov (United States)

Loesch, Anna Mira; Feddersen, Berend; Tezer, F Irsel; Hartl, Elisabeth; Rémi, Jan; Vollmar, Christian; Noachtar, Soheyl

2015-01-01

Laterality in temporal lobe epilepsy is usually defined by EEG and imaging results. We investigated whether the analysis of seizure semiology including lateralizing seizure phenomena identifies bilateral independent temporal lobe seizure onset. We investigated the seizure semiology in 17 patients in whom invasive EEG-video-monitoring documented bilateral temporal seizure onset. The results were compared to 20 left and 20 right consecutive temporal lobe epilepsy (TLE) patients who were seizure free after anterior temporal lobe resection. The seizure semiology was analyzed using the semiological seizure classification with particular emphasis on the sequence of seizure phenomena over time and lateralizing seizure phenomena. Statistical analysis included chi-square test or Fisher's exact test. Bitemporal lobe epilepsy patients had more frequently different seizure semiology (100% vs. 40%; p<0.001) and significantly more often lateralizing seizure phenomena pointing to bilateral seizure onset compared to patients with unilateral TLE (67% vs. 11%; p<0.001). The sensitivity of identical vs. different seizure semiology for the identification of bilateral TLE was high (100%) with a specificity of 60%. Lateralizing seizure phenomena had a low sensitivity (59%) but a high specificity (89%). The combination of lateralizing seizure phenomena and different seizure semiology showed a high specificity (94%) but a low sensitivity (59%). The analysis of seizure semiology including lateralizing seizure phenomena adds important clinical information to identify patients with bilateral TLE. Copyright © 2014 Elsevier B.V. All rights reserved.

The long-term course of temporal lobe epilepsy: From unilateral to bilateral interictal epileptiform discharges in repeated video-EEG monitorings.

Science.gov (United States)

Gollwitzer, Stephanie; Scott, Catherine A; Farrell, Fiona; Bell, Gail S; de Tisi, Jane; Walker, Matthew C; Wehner, Tim; Sander, Josemir W; Hamer, Hajo M; Diehl, Beate

2017-03-01

Bilateral interictal epileptiform discharges (IED) and ictal patterns are common in temporal lobe epilepsy (TLE) and have been associated with decreased chances of seizure freedom after epilepsy surgery. It is unclear whether secondary epileptogenesis, although demonstrated in experimental models, exists in humans and may account for progression of epilepsy. We reviewed consecutive video-EEG recordings from 1992 to 2014 repeated at least two years apart (mean interval 6.14years) in 100 people diagnosed with TLE. Ictal EEG patterns and IED remained restricted to one hemisphere in 36 people (group 1), 46 exhibited bilateral abnormalities from the first recording (group 2), 18 progressed from unilateral to bilateral EEG pathology over time (group 3). No significant differences between the three groups were seen with respect to age at epilepsy onset, duration, or underlying pathology. Extra-temporal IED during the first EEG recording were associated with an increased risk of developing bilateral epileptiform changes over time (hazard ratio 3.67; 95% CI 1.4, 9.4). Our findings provide some support of progression in TLE and raise the possibility of secondary epileptogenesis in humans. The development of an independent contra-lateral epileptogenic focus is known to be associated with a less favorable surgical outcome. We defined reliable EEG markers for an increased risk of progression to more widespread or independent bitemporal epileptogenicity at an early stage, thus allowing for individualized pre-surgical counselling. Copyright © 2016 Elsevier Inc. All rights reserved.

Female pattern hair loss.

Science.gov (United States)

Herskovitz, Ingrid; Tosti, Antonella

2013-10-01

Female pattern hair loss (FPHL) also known as female androgenetic alopecia is a common condition afflicting millions of women that can be cosmetically disrupting. Prompt diagnosis and treatment are essential for obtaining optimal outcome. This review addresses the clinical presentation of female pattern hair loss, its differential diagnosis and treatment modalities. A) Diffuse thinning of the crown region with preservation of the frontal hairline (Ludwig's type) B) The "Christmas tree pattern" where the thinning is wider in the frontal scalp giving the alopecic area a triangular shaped figure resembling a christmas tree. C) Thinning associated with bitemporal recession (Hamilton type). Generally, FPHL is not associated with elevated androgens. Less commonly females with FPHL may have other skin or general signs of hyperandrogenism such as hirsutism, acne, irregular menses, infertility, galactorrhea and insulin resistance. The most common endocrinological abnormality associated with FPHL is polycystic ovarian syndrome (PCOS). The most important diseases to consider in the differential diagnosis of FPHL include Chronic Telogen Effluvium (CTE), Permanent Alopecia after Chemotherapy (PAC), Alopecia Areata Incognito (AAI) and Frontal Fibrosing Alopecia (FFA). This review describes criteria for distinguishing these conditions from FPHL. The only approved treatment for FPHL, which is 2% topical Minoxidil, should be applied at the dosage of 1ml twice day for a minimum period of 12 months. This review will discuss off-label alternative modalities of treatment including 5-alfa reductase inhibitors, antiandrogens, estrogens, prostaglandin analogs, lasers, light treatments and hair transplantation.

The Neuro Imaging Description of Giant Pituitary Adenomas Depending on Mechanical Factor

Directory of Open Access Journals (Sweden)

Yu.M. Urmanova

2016-05-01

Full Text Available The research aim is to analyze of magnetically-resonance tomography data depending on the mechanical factor of giant pituitary adenomas. Materials and methods. Twenty-two adult patients with giant pituitary adenomas were observed during the period from 2015 to 2016 (men 50 %, aged 48.5 years old. The duration of disease varied from 2 months to 25 years. Results. Patients with endo-suprasellar growth of pituitary tumour had signs of chiasmal syndrome with bitemporal hemianopsia, initial or complete homonym hemianopsia, scotomas and others. Such variant of pituitary tumour growth was observed in 7 cases (31.8 %. 4.5 % patients with retro-sellar growth of pituitary tumour typically had violations caused by the growth of tumour into brainstem, that stipulated both the lesion of craniocerebral nerves and vegetative disorders, and also pyramid symptomatology (pathological reflexes, symptoms of oral automatism. Patients with the endo-laterosellar growth of tumour suffered from decline of sharpness of sight on one eye, one-sided headaches, lesion of oculomotorius. For 4.5 % patients with the endo-infrasellar growth of tumour violations of the nasal breathing and swallowing (odynophagia were typical. Conclusions. The most expressed neuroendocrine, ophthalmology and pillar disorders were observed in patients with the total growth of tumor. The giant pituitary adenomas are often accompanied by an invasion growth into surrounding anatomic structures (69.2 % that is a basic factor limiting radical operative intervention and increasing the number of relapses.

Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech.

Science.gov (United States)

Botha, Hugo; Duffy, Joseph R; Whitwell, Jennifer L; Strand, Edythe A; Machulda, Mary M; Schwarz, Christopher G; Reid, Robert I; Spychalla, Anthony J; Senjem, Matthew L; Jones, David T; Lowe, Val; Jack, Clifford R; Josephs, Keith A

2015-08-01

The consensus criteria for the diagnosis and classification of primary progressive aphasia (PPA) have served as an important tool in studying this group of disorders. However, a large proportion of patients remain unclassifiable whilst others simultaneously meet criteria for multiple subtypes. We prospectively evaluated a large cohort of patients with degenerative aphasia and/or apraxia of speech using multidisciplinary clinical assessments and multimodal imaging. Blinded diagnoses were made using operational definitions with important differences compared to the consensus criteria. Of the 130 included patients, 40 were diagnosed with progressive apraxia of speech (PAOS), 12 with progressive agrammatic aphasia, 9 with semantic dementia, 52 with logopenic progressive aphasia, and 4 with progressive fluent aphasia, while 13 were unclassified. The PAOS and progressive fluent aphasia groups were least impaired. Performance on repetition and sentence comprehension was especially poor in the logopenic group. The semantic and progressive fluent aphasia groups had prominent anomia, but only semantic subjects had loss of word meaning and object knowledge. Distinct patterns of grey matter loss and white matter changes were found in all groups compared to controls. PAOS subjects had bilateral frontal grey matter loss, including the premotor and supplementary motor areas, and bilateral frontal white matter involvement. The agrammatic group had more widespread, predominantly left sided grey matter loss and white matter abnormalities. Semantic subjects had bitemporal grey matter loss and white matter changes, including the uncinate and inferior occipitofrontal fasciculi, whereas progressive fluent subjects only had left sided temporal involvement. Logopenic subjects had diffuse and bilateral grey matter loss and diffusion tensor abnormalities, maximal in the posterior temporal region. A diagnosis of logopenic aphasia was strongly associated with being amyloid positive (46

Time to enhancement derived from ultrafast breast MRI as a novel parameter to discriminate benign from malignant breast lesions

International Nuclear Information System (INIS)

Mus, Roel D.; Borelli, Cristina; Bult, Peter; Weiland, Elisabeth; Karssemeijer, Nico; Barentsz, Jelle O.; Gubern-Mérida, Albert; Platel, Bram; Mann, Ritse M.

2017-01-01

Highlights: • New view-sharing sequences (e.g. TWIST) enable ultrafast dynamic breast MRI. • TWIST sequences accurately characterize the inflow of contrast in breast lesions. • TTE evaluation allows breast lesion classification with very high accuracy. • The use of TTE significantly increases the specificity of breast MRI. • TWIST imaging may increase the potential of breast MRI as screening tool. - Abstract: Objectives: To investigate time to enhancement (TTE) as novel dynamic parameter for lesion classification in breast magnetic resonance imaging (MRI). Methods: In this retrospective study, 157 women with 195 enhancing abnormalities (99 malignant and 96 benign) were included. All patients underwent a bi-temporal MRI protocol that included ultrafast time-resolved angiography with stochastic trajectory (TWIST) acquisitions (1.0 × 0.9 × 2.5 mm, temporal resolution 4.32 s), during the inflow of contrast agent. TTE derived from TWIST series and relative enhancement versus time curve type derived from volumetric interpolated breath-hold examination (VIBE) series were assessed and combined with basic morphological information to differentiate benign from malignant lesions. Receiver operating characteristic analysis and kappa statistics were applied. Results: TTE had a significantly better discriminative ability than curve type (p < 0.001 and p = 0.026 for reader 1 and 2, respectively). Including morphology, sensitivity of TWIST and VIBE assessment was equivalent (p = 0.549 and p = 0.344, respectively). Specificity and diagnostic accuracy were significantly higher for TWIST than for VIBE assessment (p < 0.001). Inter-reader agreement in differentiating malignant from benign lesions was almost perfect for TWIST evaluation (κ = 0.86) and substantial for conventional assessment (κ = 0.75). Conclusions: TTE derived from ultrafast TWIST acquisitions is a valuable parameter that allows robust differentiation between malignant and benign breast lesions with high

Time to enhancement derived from ultrafast breast MRI as a novel parameter to discriminate benign from malignant breast lesions

Energy Technology Data Exchange (ETDEWEB)

Mus, Roel D., E-mail: aroel.mus@radboudumc.nl [Department of Radiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen (Netherlands); Borelli, Cristina, E-mail: cristinaborelli@hotmail.it [Department of Radiology, Scientific Institute “Casa Sollievo della Sofferenza” Hospital, Viale Cappuccini 1, 71013, San Giovanni Rotondo, Foggia (Italy); Department of Radiology, Radboud University Medical Center (internal address 766), Geert Grooteplein Zuid 10, 6525GA Nijmegen (Netherlands); Bult, Peter, E-mail: peter.bult@radboudumc.nl [Department of Pathology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen (Netherlands); Weiland, Elisabeth, E-mail: elisabeth.weiland@siemens.com [Siemens Healthcare, Erlangen (Germany); Karssemeijer, Nico, E-mail: nico.karssemeijer@radboudumc.nl [Department of Radiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen (Netherlands); Barentsz, Jelle O., E-mail: jelle.barentsz@radboudumc.nl [Department of Radiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen (Netherlands); Gubern-Mérida, Albert, E-mail: albert.gubernmerida@radboudumc.nl [Department of Radiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen (Netherlands); Platel, Bram, E-mail: bram.platel@radboudumc.nl [Department of Radiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen (Netherlands); Mann, Ritse M., E-mail: ritse.mann@radboudumc.nl [Department of Radiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen (Netherlands)

2017-04-15

Highlights: • New view-sharing sequences (e.g. TWIST) enable ultrafast dynamic breast MRI. • TWIST sequences accurately characterize the inflow of contrast in breast lesions. • TTE evaluation allows breast lesion classification with very high accuracy. • The use of TTE significantly increases the specificity of breast MRI. • TWIST imaging may increase the potential of breast MRI as screening tool. - Abstract: Objectives: To investigate time to enhancement (TTE) as novel dynamic parameter for lesion classification in breast magnetic resonance imaging (MRI). Methods: In this retrospective study, 157 women with 195 enhancing abnormalities (99 malignant and 96 benign) were included. All patients underwent a bi-temporal MRI protocol that included ultrafast time-resolved angiography with stochastic trajectory (TWIST) acquisitions (1.0 × 0.9 × 2.5 mm, temporal resolution 4.32 s), during the inflow of contrast agent. TTE derived from TWIST series and relative enhancement versus time curve type derived from volumetric interpolated breath-hold examination (VIBE) series were assessed and combined with basic morphological information to differentiate benign from malignant lesions. Receiver operating characteristic analysis and kappa statistics were applied. Results: TTE had a significantly better discriminative ability than curve type (p < 0.001 and p = 0.026 for reader 1 and 2, respectively). Including morphology, sensitivity of TWIST and VIBE assessment was equivalent (p = 0.549 and p = 0.344, respectively). Specificity and diagnostic accuracy were significantly higher for TWIST than for VIBE assessment (p < 0.001). Inter-reader agreement in differentiating malignant from benign lesions was almost perfect for TWIST evaluation (κ = 0.86) and substantial for conventional assessment (κ = 0.75). Conclusions: TTE derived from ultrafast TWIST acquisitions is a valuable parameter that allows robust differentiation between malignant and benign breast lesions with high

The potential of transcranial magnetotherapy in color and rhythm therapy in the rehabilitation of ischemic stroke.

Science.gov (United States)

Sholomov, I I; Cherevashchenko, L A; Suprunov, O V; Raigorodskii, Yu M

2010-10-01

A total of 116 patients with ischemic stroke were studied during the early recovery period. The patients were divided into four groups - three experimental groups and one control group. Of these, 87 patients in the first three groups received transcranial magneto- and/or color and rhythm therapy (TcMT, CRT) along with traditional treatment, while the 29 patients of the control group received basal treatment only. TcMT was performed using a bitemporal method, with a running field regime with a modulation frequency of 1-10 Hz. CRT consisted of an alternating scheme of stimulation of the left and right eyes with green and/or blue light with a period of 2-4 sec and an on time of 1 sec. Each of the three experimental groups (group 1 received TcMT, group 2 received CRT, and group 3 received TcMT + CRT) received two courses of treatment separated by 1.5 months. After treatment, all experimental groups, particularly group 3, showed more marked improvements than the control group. Regression of neurological symptomatology on the Lindmark scale in group 3 was 9.5% greater than that in controls; improvements in impairments to activity and self-care ability on the Barthel scale were greater by 8.8%; memory and intellectual changes were also seen on the MMSE and the Luriya and Schulte tests. Rheography and electroencephalography demonstrated significant improvements in hemodynamics and alpha-rhythm differentiation and a 14.6% reduction in the proportion of patients with dysrhythmia in group 3 compared with the control group. The best result on all measures were obtained in patients given the combination of TcMT and CRT; TcMT had the greater influence on hemodynamics, while CRT had the greater effect on psychoemotional status. Both treatments were well tolerated and produced no side effects.

Alterações visuais decorrentes do cisto da fenda de Rathke: relato de caso Visual alterations due to Rathke's cleft cyst: case report

Directory of Open Access Journals (Sweden)

Gustavo Valandro Rech

2004-12-01

Full Text Available Os cistos da fenda de Rathke são lesões para-selares, geralmente assintomáticas, presentes em 12 a 33% das autópsias de pacientes com hipófise normal. Ocasionalmente, os cistos podem aumentar de volume a ponto de comprimir estruturas supra-selares e intra-selares, levando ao aparecimento dos sintomas. Clinicamente, os pacientes referem escurecimento visual, além de apresentarem defeitos campimétricos. M.A.S.R., 47 anos, sexo feminino, branca, natural de Pelotas/RS com queixa de embaçamento progressivo da visão do olho direito há 2 meses. Ao exame, constatou-se baixa visual e hemianopsia bitemporal. A tomografia computadorizada evidenciou imagem hipodensa arredondada, de bordos nítidos, em topografia selar, determinando remodelação e alargamento da sela túrcica. A ressonância magnética mostrou lesão expansiva cística localizada na sela túrcica com crescimento supra-selar. A referida lesão apresenta obliteração da cisterna supra-selar e importante compressão sobre o quiasma óptico. A abordagem cirúrgica confirmou a presença de lesão expansiva cística comprimindo o quiasma óptico e o exame de anatomia patológica do material diagnosticou cisto da fenda de Rathke. O exame oftalmológico, três meses após a cirurgia, mostrou melhora da acuidade visual e recuperação total dos defeitos do campo visual. O cisto da fenda de Rathke deve ser incluído no diagnóstico diferencial dos tumores para-selares passíveis de causar compressão da via óptica nervosa e ressalta-se a importância do diagnóstico e tratamento precoce no intuito de prevenir danos estruturais com perdas irreversíveis da função visual, bem como os distúrbios endócrinos.Rathke's cleft cysts are parasellar lesions, which are usually asymptomatic and found in 12 to 33% of autopsies done on patients with normal pituitary gland. Occasionally, the cysts can swell up to the point of putting pressure on the suprasellar and intrasellar structures, which

Evaluating the trade-off between food and timber resulting from the conversion of Miombo forests to agricultural land in Angola using multi-temporal Landsat data.

Science.gov (United States)

Schneibel, Anne; Stellmes, Marion; Röder, Achim; Finckh, Manfred; Revermann, Rasmus; Frantz, David; Hill, Joachim

2016-04-01

The repopulation of abandoned areas in Angola after 27years of civil war led to a fast and extensive expansion of agricultural fields to meet the rising food demand. Yet, the increase in crop production at the expense of natural resources carries an inherent potential for conflicts since the demand for timber and wood extraction are also supposed to rise. We use the concept of ecosystem services to evaluate the trade-off between food and woody biomass. Our study area is located in central Angola, in the highlands of the upper Okavango catchment. We used Landsat data (spatial resolution: 30×30m) with a bi-temporal and multi-seasonal change detection approach for five time steps between 1989 and 2013 to estimate the conversion area from woodland to agriculture. Overall accuracy is 95%, user's accuracy varies from 89-95% and producer's accuracy ranges between 92-99%. To quantify the trade-off between woody biomass and the amount of food, this information was combined with indicator values and we furthermore assessed biomass regrowth on fallows. Our results reveal a constant rise in agricultural expansion from 1989-2013 with the mean annual deforestation rate increasing from roughly 5300ha up to about 12,000ha. Overall, 5.6% of the forested areas were converted to agriculture, whereas the FAO states a national deforestation rate for Angola of 5% from 1990-2010 (FAO, 2010). In the last time step 961,000t per year of woodland were cleared to potentially produce 1240t per year of maize. Current global agro-economical projections forecast increasing pressure on tropical dry forests from large-scale agriculture schemes (Gasparri et al., 2015; Searchinger and Heimlich, 2015). Our study underlines the importance of considering subsistence-related change processes, which may contribute significantly to negative effects associated with deforestation and degradation of these forest ecosystems. Copyright © 2016 Elsevier B.V. All rights reserved.

Mapping Fire Severity Using Imaging Spectroscopy and Kernel Based Image Analysis

Science.gov (United States)

Prasad, S.; Cui, M.; Zhang, Y.; Veraverbeke, S.

2014-12-01

Improved spatial representation of within-burn heterogeneity after wildfires is paramount to effective land management decisions and more accurate fire emissions estimates. In this work, we demonstrate feasibility and efficacy of airborne imaging spectroscopy (hyperspectral imagery) for quantifying wildfire burn severity, using kernel based image analysis techniques. Two different airborne hyperspectral datasets, acquired over the 2011 Canyon and 2013 Rim fire in California using the Airborne Visible InfraRed Imaging Spectrometer (AVIRIS) sensor, were used in this study. The Rim Fire, covering parts of the Yosemite National Park started on August 17, 2013, and was the third largest fire in California's history. Canyon Fire occurred in the Tehachapi mountains, and started on September 4, 2011. In addition to post-fire data for both fires, half of the Rim fire was also covered with pre-fire images. Fire severity was measured in the field using Geo Composite Burn Index (GeoCBI). The field data was utilized to train and validate our models, wherein the trained models, in conjunction with imaging spectroscopy data were used for GeoCBI estimation wide geographical regions. This work presents an approach for using remotely sensed imagery combined with GeoCBI field data to map fire scars based on a non-linear (kernel based) epsilon-Support Vector Regression (e-SVR), which was used to learn the relationship between spectra and GeoCBI in a kernel-induced feature space. Classification of healthy vegetation versus fire-affected areas based on morphological multi-attribute profiles was also studied. The availability of pre- and post-fire imaging spectroscopy data over the Rim Fire provided a unique opportunity to evaluate the performance of bi-temporal imaging spectroscopy for assessing post-fire effects. This type of data is currently constrained because of limited airborne acquisitions before a fire, but will become widespread with future spaceborne sensors such as those on

Le cinéma en Afrique : l’impossible industrie

Directory of Open Access Journals (Sweden)

Claude Forest

2012-08-01

Full Text Available Les complaintes sont nombreuses face aux difficultés de la production cinématographique comme à la fermeture des salles sur un continent africain aux évolutions hétérogènes. Une analyse des causes qui ont mené à cette situation et un état des lieux de cette industrie constituent un préalable indispensable à l’éventuelle adoption de remèdes appropriés. Si quelques pays comme le Nigéria ou l’Afrique du Sud font figure d’exceptions sans pour autant pouvoir devenir des modèles, il n’est pas certain que la numérisation contemporaine de la filière aide à surmonter radicalement ses difficultés structurelles. Au-delà des discours convenus d’apitoiement ou de déploration, il conviendra d’étudier les principaux symptômes et leurs multiples causes, à commencer par les attentes et comportements des publics, mais également les dysfonctionnements politiques et économiques beaucoup plus larges qui touchent une majorité de ces nations et interdisent la structuration pérenne d’une industrie du cinéma, sans empêcher l’émergence d’autres formes de partage collectif d’images diffusées qui retiennent peu l’attention des nations occidentales bien que massivement pratiquées.Film production in Africa encounters numerous difficulties while at the same time theaters close down. An essential prerequisite to the possible adoption of appropriate remedies to this situation is an analysis of the causes which led to the extinction of theaters and the comprehension of the industry's current structure. If some countries such as Nigeria or South Africa seem more like an exception to the rule without, thus, being able to become models, it is not certain that the contemporary digitalization of the sector helps to radically overcome its structural difficulties. Instead of succumbing to discourses of victimization, it would be better to study the main symptoms and the multiple causes, to start with the audiences' expectations

Aneurisma gigante parasselar simulando tumor de hipófise

Directory of Open Access Journals (Sweden)

Luiz Augusto Casulari Roxo da Motta

1988-12-01

Full Text Available Revisamos 7 pacientes com comprometimento da sela turca ao raio X do crânio que apresentavam aneurisma gigante da porção intracavernosa da artéria carótida (6 casos e aneurisma da artéria comunicante anterior (1 caso. As alterações encontradas foram: cefaléia (7/7, oftalmoplegia complexa interessando III, IV e VI nervos cranianos (5/7 e comprometimento do V nervo (4/7, dor ocular (4/7. Outras alterações encontradas foram: sinais meníngeos (2/7, cegueira unilateral (1/7, hemiparesia (1/7 cacosmia (1/7 e quadrantanopsia bitemporal inferior (1/7. Cinco pacientes com aneurisma da porção intracavernosa da artéria carótida beneficiaram-se com a ligadura progressiva da artéria carótida interna a nível cervical; o outro paciente faleceu antes da realização da operação. O paciente com aneurisma da artéria comunicante anterior foi submetido a clipagem do aneurisma, tendo boa evolução. Baseados neste estudo e em concordância com a literatura, concluímos que o diagnóstico diferencial entre aneurisma localizado na região parasselar e outras patologias dessa área freqüentemente apresenta dificuldade. O diagnóstico definitivo requer a realização de angiografia cerebral. O tratamento cirúrgico, por ligadura da carótida interna na região cervical, é benéfico e quase desprovido de complicações.

Disturbed neural circuits in a subtype of chronic catatonic schizophrenia demonstrated by F-18-FDG-PET and F-18-DOPA-PET

International Nuclear Information System (INIS)

Lauer, M.; Beckmann, H.; Stoeber, G.; Schirrmeister, H.; Gerhard, A.; Ellitok, E.; Reske, S.N.

2001-01-01

Permanent verbal, visual scenic and coenaestetic hallucinations are the most prominent psychopathological symptoms aside from psychomotor disorders in speech-sluggish catatonia, a subtype of chronic catatonic schizophrenia according to Karl Leonhard. These continuous hallucinations serve as an excellent paradigm for the investigation of the assumed functional disturbances of cortical circuits in schizophrenia. Data from positron emission tomography (F-18-FDG-PET and F-18-DOPA-PET) from three patients with this rare phenotype were available (two cases of simple speech-sluggish catatonia, one case of a combined speech-prompt/speech-sluggish subtype) and were compared with a control collective. During their permanent hallucinations, all catatonic patients showed a clear bitemporal hypometabolism in the F-18-FDG-PET. Both patients with the simple speech-sluggish catatonia showed an additional bilateral thalamic hypermetabolism and an additional bilateral hypometabolism of the frontal cortex, especially on the left side. In contrast, the patient with the combined speech-prompt/speech-sluggish catatonia showed a bilateral thalamic hypo-metabolism combined with a bifrontal cortical hypermetabolism. However, the left/right ratio of the frontal cortex also showed a lateralization effect with a clear relative hypometabolism of the left frontal cortex. The F-18-DOPA-PET of both schizophrenic patients with simple speech-sluggish catatonia showed a normal F-18-DOPA storage in the striatum, whereas in the right putamen of the patient with the combined form a higher right/left ratio in F-DOPA storage was discernible, indicating an additional lateralized influence of the dopaminergic system in this subtype of chronic catatonic schizophrenia. (author)

Female Pattern Hair Loss

Science.gov (United States)

Herskovitz, Ingrid; Tosti, Antonella

2013-01-01

Context: Female pattern hair loss (FPHL) also known as female androgenetic alopecia is a common condition afflicting millions of women that can be cosmetically disrupting. Prompt diagnosis and treatment are essential for obtaining optimal outcome. This review addresses the clinical presentation of female pattern hair loss, its differential diagnosis and treatment modalities. Evidence Acquisition: A) Diffuse thinning of the crown region with preservation of the frontal hairline (Ludwig’s type) B) The “Christmas tree pattern” where the thinning is wider in the frontal scalp giving the alopecic area a triangular shaped figure resembling a christmas tree. C) Thinning associated with bitemporal recession (Hamilton type). Generally, FPHL is not associated with elevated androgens. Less commonly females with FPHL may have other skin or general signs of hyperandrogenism such as hirsutism, acne, irregular menses, infertility, galactorrhea and insulin resistance. The most common endocrinological abnormality associated with FPHL is polycystic ovarian syndrome (PCOS). Results: The most important diseases to consider in the differential diagnosis of FPHL include Chronic Telogen Effluvium (CTE), Permanent Alopecia after Chemotherapy (PAC), Alopecia Areata Incognito (AAI) and Frontal Fibrosing Alopecia (FFA). This review describes criteria for distinguishing these conditions from FPHL. Conclusions: The only approved treatment for FPHL, which is 2% topical Minoxidil, should be applied at the dosage of 1ml twice day for a minimum period of 12 months. This review will discuss off-label alternative modalities of treatment including 5-alfa reductase inhibitors, antiandrogens, estrogens, prostaglandin analogs, lasers, light treatments and hair transplantation. PMID:24719635

Familial Pallister-Hall in adulthood.

Science.gov (United States)

Talsania, Mitali; Sharma, Rohan; Sughrue, Michael E; Scofield, R Hal; Lim, Jonea

2017-10-01

Pallister Hall syndrome is autosomal dominant disorder usually diagnosed in infants and children. Current diagnostic criteria include presence of hypothalamic hamartoma, post axial polydactyly and positive family history, but the disease has variable manifestations. Herein we report Pallister Hall syndrome diagnosed in a family where both patients were adults. A 59 year old man developed seizures 4 years prior to our evaluation of him, at which time imaging showed a hypothalamic hamartoma. The seizures were controlled medically. He did well until he had visual changes after a traumatic head injury. Repeat MRI showed slight expansion of the mass with formal visual field testing demonstrating bitemporal hemianopsia. There was no evidence of pituitary dysfunction except for large urine volume. He underwent surgery to debulk the hamartoma and the visual field defects improved. There was no hypopituitarism post-operatively, and the polydyspia resolved. His 29 year old daughter also had seizures and hypothalamic hamartoma. Both patients had had polydactyly with prior surgical correction in childhood. The daughter underwent genetic testing, which revealed a previously undescribed heterozygous single base pair deletion in exon 13 of the GLI3 gene causing a frameshift mutation. Further investigation into family history revealed multiple members in previous generations with polydactyly and/or seizures. Pallister-Hall syndrome is caused by an inherited autosomal dominant or de novo mutation in GLI3 gene. This rare syndrome has not had prevalence defined, however. Generally, diagnoses are made in the pediatric population. Our report adds to the few cases detected in adulthood.

Holoprosencephaly: ZIC2 mutation in a case with panhypopituitarism.

Science.gov (United States)

Tasdemir, Sener; Sahin, Ibrahim; Cayır, Atilla; Doneray, Hakan; Solomon, Benjamin D; Muenke, Maximilian; Yuce, Ihsan; Tatar, Abdulgani

2014-07-01

Holoprosencephaly (HPE), the most common malformation of the brain, results from failed or incomplete separation of the embryonic forebrain (prosencephalon). HPE occurs in approximately 1 in 250 embryos and in about 1 in 10,000 births. It is etiologically heterogeneous, and may be caused by cytogenetic anomalies and teratogenic influences; it occurs as part of a syndrome, or due to heterozygous mutations in 1 of over 10 HPE-associated genes. ZIC2 mutations are the second-most common cause of non-syndromic non-chromosomal HPE (after sonic hedgehog) and occur de novo in 74% of the affected probands. The objective of the study was to describe the first case of ZIC2-related HPE with both anterior and posterior pituitary insufficiencies. We report about a 2-year-8-month-old boy who was born as a second child in a non-consanguineous healthy Turkish family. He has the characteristic ZIC2 phenotype: bitemporal narrowing, upslanting palpebral fissures, large ears, short nose with anteverted nares and broad and deep philtrum. Magnetic resonance imaging revealed alobar HPE. During laboratory investigation, his blood sodium level was 158 mmol/L and the specific gravity of his urine was 1.002. Serum osmolarity was 336 mOsm/L and urine osmolality was 135 mOsm/kg. His FT4 was 0.8 ng/dL and TSH was 0.79 mLU/mL. Response to vasopressin confirmed the diagnosis of central diabetes insipidus and TRH-stimulating test supported the central hypothyroidism. A frameshift mutation (NM_007129.2:c1091_1092 del, p.Gln364Leufs*2) in the ZIC2 gene was detected. Pituitary insufficiency other than isolated diabetes insipidus is a rare finding of HPE, and occurs most frequently in patients with GLI2 mutations (the phenotype of which typically does not include frank neuroanatomic anomalies such as HPE); ours is the only described patient with a ZIC2 mutation and both anterior and posterior pituitary dysfunction.

Hair loss in women: medical and cosmetic approaches to increase scalp hair fullness.

Science.gov (United States)

Sinclair, R; Patel, M; Dawson, T L; Yazdabadi, A; Yip, L; Perez, A; Rufaut, N W

2011-12-01

Androgenetic alopecia affects both men and women. In men it produces male pattern hair loss with bitemporal recession and vertex baldness. In women it produces female pattern hair loss (FPHL) with diffuse alopecia over the mid-frontal scalp. FPHL occurs as a result of nonuniform hair follicle miniaturization within follicular units. Diffuse alopecia is produced by a reduction in the number of terminal fibres per follicular unit. Baldness occurs only when all hairs within the follicular units are miniaturized and is a relatively late event in women. The concepts of follicular units and primary and secondary hair follicles within follicular units are well established in comparative mammalian studies, particularly in sheep. However, discovery of these structures in the human scalp hair and investigation of the changes in follicular unit anatomy during the development of androgenetic alopecia have provided a clearer understanding of the early stages of androgenetic alopecia and how the male and female patterns of hair loss are related. FPHL is the most common cause of alopecia in women and approximately one-third of adult caucasian women experience hair loss. The impact of FPHL is predominantly psychological. While men anticipate age-related hair loss, hair loss in women is usually unexpected and unwelcome at any age. Treatment options to arrest hair loss progression and stimulate partial hair regrowth for FPHL include the androgen receptor antagonists spironolactone and cyproterone acetate, the 5α-reductase inhibitor finasteride and the androgen-independent hair growth stimulator minoxidil. These treatments appear to work best when initiated early. Hair transplantation should be considered in advanced FPHL that is resistant to medical treatments. Hair transplantation requires well-preserved hair growth over the occipital donor area. The psychological impact of FPHL may also be reduced by cosmetic products that improve the appearance of the hair. These agents work to

Winter Crop Mapping for Improving Crop Production Estimates in Argentina Using Moderation Resolution Satellite Imagery

Science.gov (United States)

Humber, M. L.; Copati, E.; Sanchez, A.; Sahajpal, R.; Puricelli, E.; Becker-Reshef, I.

2017-12-01

Accurate crop production data is fundamental for reducing uncertainly and volatility in the domestic and international agricultural markets. The Agricultural Estimates Department of the Buenos Aires Grain Exchange has worked since 2000 on the estimation of different crop production data. With this information, the Grain Exchange helps different actors of the agricultural chain, such as producers, traders, seed companies, market analyst, policy makers, into their day to day decision making. Since 2015/16 season, the Grain Exchange has worked on the development of a new earth observations-based method to identify winter crop planted area at a regional scale with the aim of improving crop production estimates. The objective of this new methodology is to create a reliable winter crop mask at moderate spatial resolution using Landsat-8 imagery by exploiting bi-temporal differences in the phenological stages of winter crops as compared to other landcover types. In collaboration with the University of Maryland, the map has been validated by photointerpretation of a stratified statistically random sample of independent ground truth data in the four largest producing provinces of Argentina: Buenos Aires, Cordoba, La Pampa, and Santa Fe. In situ measurements were also used to further investigate conditions in the Buenos Aires province. Preliminary results indicate that while there are some avenues for improvement, overall the classification accuracy of the cropland and non-cropland classes are sufficient to improve downstream production estimates. Continuing research will focus on improving the methodology for winter crop mapping exercises on a yearly basis as well as improving the sampling methodology to optimize collection of validation data in the future.

Orbitopterional Approach for the Resection of a Suprasellar Craniopharyngioma: Adapting the Strategy to the Microsurgical and Pathologic Anatomy.

Science.gov (United States)

Nguyen, Vincent; Basma, Jaafar; Klimo, Paul; Sorenson, Jeffrey; Michael, L Madison

2018-04-01

Objectives  To describe the orbitopterional approach for the resection of a suprasellar craniopharyngioma with emphasis on the microsurgical and pathological anatomy of such lesions. Design  After completing the orbitopterional craniotomy in one piece including a supraorbital ridge osteotomy, the Sylvian fissure was split in a distal to proximal direction. The ipsilateral optic nerve and internal carotid artery were identified. Establishing a corridor to the tumor through both the opticocarotid and optic cisterns allowed for a wide angle of attack. Using both corridors, a microsurgical gross total resection was achieved. A radical resection required transection of the stalk at the level of the hypothalamus. Photographs of the region are borrowed from Dr Rhoton's laboratory to illustrate the microsurgical anatomy. Understanding the cisternal and topographic relationships of the optic nerve, optic chiasm, and internal carotid artery is critical to achieving gross total resection while preserving normal anatomy. Participants  The surgery was performed by the senior author assisted by Dr. Jaafar Basma. The video was edited by Dr. Vincent Nguyen. Outcome Measures  Outcome was assessed with extent of resection and postoperative visual function. Results  A gross total resection of the tumor was achieved. The patient had resolution of her bitemporal hemianopsia. She had diabetes insipidus with normal anterior pituitary function. Conclusions  Understanding the microsurgical anatomy of the suprasellar region and the pathological anatomy of craniopharyngiomas is necessary to achieve a good resection of these tumors. The orbitopterional approach provides the appropriate access for such endeavor. The link to the video can be found at: https://youtu.be/Be6dtYIGqfs .

Microsurgical Resection of Suprasellar Craniopharyngioma-Technical Purview.

Science.gov (United States)

Nanda, Anil; Narayan, Vinayak; Mohammed, Nasser; Savardekar, Amey R; Patra, Devi Prasad

2018-04-01

Objectives  Complete surgical resection is an important prognostic factor for recurrence and is the best management for craniopharyngioma. This operative video demonstrates the technical nuances in achieving complete resection of a suprasellar craniopharyngioma. Design and Setting  The surgery was performed in a middle-aged lady who presented with the history of progressive bitemporal hemianopia and excessive sleepiness over 8 months. On imaging, suprasellar craniopharyngioma was identified. The tumor was approached through opticocarotid cistern and lamina terminalis. Exposure of bilateral optic nerves, right internal carotid artery, anterior cerebral artery, and its perforator branches was then afforded and the tumor was gross totally resected. Results  The author demonstrates step-by-step technique of microsurgical resection of suprasellar craniopharyngioma. The narrow corridor to deeper structures, intricacies of multiple perforator vessels, and the technique of arachnoid and capsule dissection are the main challenging factors for the gross total resection of craniopharyngioma. The tumor portion which lies under the ipsilateral optic nerve is a blind spot region with a high chance of leaving residual tumor. Mobilization of optic nerve may endanger visual function too. The use of handheld mirror ['mirror-technique'] helps in better visualization of this blind spot and achieve complete excision. Conclusions  The technical pearls of craniopharyngioma surgery include the optimum utilization of translamina terminalis route, wide opening of the cisterns, meticulous separation of deep perforator vessels, capsular mobilization/traction avoidance, and the use of "mirror-technique" for blind-spot visualization. These surgical strategies help to achieve complete resection without causing neurological deficit. The link to the video can be found at: https://youtu.be/9wHJ4AUpG50 .

Cavernous hemangioma presenting marked hyperostosis

International Nuclear Information System (INIS)

Kobata, Hitoshi; Miyake, Hiroji; Kitamura, Junji; Kajikawa, Hiroshi; Ohta, Tomio

1988-01-01

The authors report here a case of hemangioma of the left parietal bone which presented headache and papilledema. This patient is a 37-year-old female who had, prior to admission, complained of increasing headache for one year and blurred vision for three months. She had no history of head injury. Local physical examinations revealed a slight bulging in her left parietal region which was insensitive to palpation and not adherent to the overlying scalp. Neurological examinations revealed bilateral papilledema and an incongruous bitemporal upper quadrant defect in the visual field. All the other neurological and laboratory data were normal. A plain skull roentogenogram showed a 9 x 9 cm osteolytic and characteristic honeycomb lesion in the parietal region. Systemic bone survey revealed a similar lesion in the right tibia which was not histologically examined. A marked accumulation of isotopes was detected on the bone scintigrams at both lesions. Selective external carotid angiograms demonstrated a tumor stain fed by the superficial temporal, occipital, and middle meningial arteries. CT scans of the brain and skull clearly showed a local thickening of and structural changes in the skull bone and also a mass effect on the brain and lateral ventricle. The lesioned bone was removed en bloc and replaced by an artificial bone. It was highly vascular, but not adherent to the overlying dura. The post-operative course was uneventful, and the headache and papilledema disappeared. Hemangioma of the skull presenting marked hyperostosis, as reported above, seems to be rare. In addition, in this case, skeletal angioma without any clinical manifestation was detected. Clinical and radiological pictures of the hemangioma of the skull and other bones were briefly discussed. (author)

Delayed radiation necrosis in the optochiasmatic region

International Nuclear Information System (INIS)

Andoh, Takashi; Yokoyama, Kazutoshi; Kumagai, Morio

1984-01-01

Two cases with delayed radiation necrosis of the chiasmatic region following irradiation of the hypophysis for treatment of Cushing's disease were presented. Case 1 was a 36-year-old female who had reduction of visual acuity and bitemporal hemianopsia 2 years after 60 Co-irradiation therapy (total 8000 rads) for Cushing's disease. CT scans showed low density in the pituitary fossa and irregular contrast-enhanced suprasellar mass, and metrizamide CT cisternography revealed the pituitary fossa filled with contrast medium. From those findings, secondary empty sella syndrome was suspicious. Case 2 was a 35-year-old male who had progressive visual disturbance 3 years after 60 Co-irradiation therapy (total 9050 rads) for Cushing's disease. The right visual acuity was 0.05 and the left one was 0.1. Examination of visual field showed left homonymous hemianopsia. CT scans showed the contrast enhanced suprasellar mass extending to the right anterior thalamic region, and metrizamide CT cisternography detected secondary empty sella as same as that of Case 1. Authors reviewed and analyzed literatures of delayed radiation necrosis. The incidence of this condition was 4% to 9% and onset of the symptoms occured approximately 2 years after irradiation to hypophysis. Administration of steroid hormone and surgical treatment for the radiation necrosis involving the chiasmatic region were almost ineffective and also the prognosis of radionecrotic lesions involving the hypothalamus was very poor. Therefore, radiotherapy for hypophyseal region must be carried out by means of a rotation or arching technique in order to avoid this condition and further total dosage and its fractionation in radiation therapy should not exceed 6000 rads and 200 rads a day. (J.P.N.)

Partial trisomy 14q and monosomy 20q due to an unbalanced familial translocation

Energy Technology Data Exchange (ETDEWEB)

Menasse-Palmer, L; Leo, J.; Cannizaro, L. [Albert Einstein College of Medicine, Bronx, NY (United States)] [and others

1994-09-01

Partial trisomy of distal 14q and monosomy of 20q are rare. There have been several reports of a partial distal trisomy 14q with characteristic clinical findings, including hypogonadism and a conotruncal cardiac anomaly. There is no deletion distal 20q syndrome. We have recently examined a newborn with this unique duplication/deletion syndrome. Case report: J.S. was the 2980 gm product of a term uneventful pregnancy delivered to a 24-year-old gravida 2, para 1001 mother. The newborn exam revealed a dysmorphic newborn male with a sloping forehead, bitemporal narrowing, glabellar furrowing and micrognathia. A systolic murmur was audible. The genital abnormalities were micropenis, hypospadias with chordee and bifid scrotum with prominent raphe, and gonads were palpable. A CAT scan of the head revealed grade I IVH. An echocardiogram showed a VSD, ASD and an AP window. A sonogram of the liver showed absence of the gallbladder. Chromosome analysis revealed an abnormal male karyotype containing a derivative 20, subsequently shown to be inherited as a result of malsegregation of a paternal translocation: 46,XY,-20,+der(20)t(14;20)(q32.1;q13.3)pat. The infant fed poorly and required tube feedings and was treated for congestive heart failure with Digoxin, Lasix and oxygen. A decreased cortisol level and cholestasis were noted. The infant died after a cardiopulmonary arrest at one month of age. No post-mortem was obtained. Clinical cytogenetic correlation (conotruncal abnormality and hypogonadism) with partial duplication of distal 14q was positive. This case helps to further delineate duplication 14q and a syndrome due to partial deletion 20q.

Partial trisomy 5q resulting from chromosome 7 insertion: An expansion of the phenotype

Energy Technology Data Exchange (ETDEWEB)

Fries, M.H.; Reilly, P.A.; Williams, T.C. [Keesler Medical Center, MS (United States)] [and others

1994-09-01

Partial trisomy 5q has been categorized into three separate phenotypes; however, a distinctive phenotype has not been described for duplications spanning 5q23-q35. We report a case of partial trisomy 5q for this region as a result of a ins(7,5)(q31.3;q23.2q35.1)mat. The liveborn male infant was delivered by emergency cesarean section at 37 weeks after a pregnancy notable for oligohydramnios, with birth weight 1792 g (<3%). Postnatal course was marked by psychomotor delay, failure to thrive, and biopsy demonstrated neonatal giant cell hepatitis with a paucity of intrahepatic bile ducts. His appearance was remarkable for lack of subcutaneous fat, midline displaced hair whorl, bitemporal narrowing with frontal bossing, wide anterior fontanel, widow`s peak, protuberant eyes with periorbital and lid edema, short flat nasal bridge with broad flattened nasal tip, long smooth philtrum, wide mouth with thin lips, wide gingival ridges, micrognathia, posteriorly rotated low-set ears, hepatomegaly, flexion contractions of elbows, and generalized hypertonicity. Urine organic acids, oligosaccharide/mucopolysaccharide screen, and plasma amino acids were negative. GTG-banding on prometaphase chromosomes showed an unbalanced translocation involving chr. 7. This was identified as an insertion of chr. 5 (q23.2q35.1) into distal 7q after FISH using chr. 5 and chr. 7 painting probes. The infant`s mother carries the balanced insertional rearrangement: 46,XX,dir ins(7,5)(q31.3;q23.2q35.1). This phenotype overlaps that of previously described duplications with the addition of giant cell hepatitis, coarsened facial features, gingival thickening, and flexion contractures, suggestive of a yet undiagnosed storage disorder.

Factores de Riesgo para Recurrencia de Convulsiones y Pronóstico a Corto Plazo en Cirugía de Epilepsia para Esclerosis Mesial Temporal.

Directory of Open Access Journals (Sweden)

Héctor Jaramillo Betancur

2009-07-01

, esclerosis mesial temporal, factores de riesgo, pronóstico, recurrencia.

Summary

Aim: To establish risk factors for seizure recurrence and short term Engel classification after surgery for Mesial Temporal Sclerosis (MTS.

Patients and methods: Nested case-control study in a cohort of patients diagnosed with MTS by magnetic resonance imaging and who had at least two years of postsurgical follow-up; patients with bilateral MTS were excluded. Clinical characteristics, epileptogenic focus in video- EEG and surgical issues were evaluated regarding to seizure recurrence during the first two postsurgical years and Engel classification in the first and second anniversary after surgery.

Results: From October 2001 to June 2008, 144 patients with MTS were evaluated as candidates for epilepsy surgery; until June 2007, 89 patients underwent epilepsy surgery, 51.7% with left MTS. 35.8% of patients experienced seizure recurrence before two post-surgical years; presurgical risk factor associated to this recurrence was bitemporal focus or single temporal focus with contralateral dissemination by video-EEG (OR: 6.32; CI95% 1.64-26.41, and post-surgical, seizures that occurred in the first month of surgery (p: 0004. No association with seizure recurrence was found with gender, presurgical tonic-clonic seizures, MTS side and epilepsy duration. 66.3% and 75.8% of patients were Engel I classified in the first and second anniversary after surgery, respectively. 91% of operated patients showed a good outcome after two years of epilepsy surgery.

Conclusion: Epileptogenic focus location by electrophysiology is a fundamental factor in short term outcome after surgery for MTS.

Key words

Epilepsy surgery, mesial temporal sclerosis, outcome, recurrence, risk factors, seizures, temporal lobe epilepsy.

Nail gun injuries to the head with minimal neurological consequences: a case series.

Science.gov (United States)

Makoshi, Ziyad; AlKherayf, Fahad; Da Silva, Vasco; Lesiuk, Howard

2016-03-16

An estimated 3700 individuals are seen annually in US emergency departments for nail gun-related injuries. Approximately 45 cases have been reported in the literature concerning nail gun injuries penetrating the cranium. These cases pose a challenge for the neurosurgeon because of the uniqueness of each case, the dynamics of high pressure nail gun injuries, and the surgical planning to remove the foreign body without further vascular injury or uncontrolled intracranial hemorrhage. Here we present four cases of penetrating nail gun injuries with variable presentations. Case 1 is of a 33-year-old white man who sustained 10 nail gunshot injuries to his head. Case 2 is of a 51-year-old white man who sustained bi-temporal nail gun injuries to his head. Cases 3 and 4 are of two white men aged 22 years and 49 years with a single nail gun injury to the head. In the context of these individual cases and a review of similar cases in the literature we present surgical approaches and considerations in the management of nail gun injuries to the cranium. Case 1 presented with cranial nerve deficits, Case 2 required intubation for low Glasgow Coma Scale, while Cases 3 and 4 were neurologically intact on presentation. Three patients underwent angiography for assessment of vascular injury and all patients underwent surgical removal of foreign objects using a vice-grip. No neurological deficits were found in these patients on follow-up. Nail gun injuries can present with variable clinical status; mortality and morbidity is low for surgically managed isolated nail gun-related injuries to the head. The current case series describes the surgical use of a vice-grip for a good grip of the nail head and controlled extraction, and these patients appear to have a good postoperative prognosis with minimal neurological deficits postoperatively and on follow-up.

Endoscopic Endonasal Transplanum Transtuberculum Approach for the Resection of a Large Suprasellar Craniopharyngioma.

Science.gov (United States)

Mangussi-Gomes, João; Vellutini, Eduardo A; Truong, Huy Q; Pahl, Felix H; Stamm, Aldo C

2018-04-01

Objectives  To demonstrate an endoscopic endonasal transplanum transtuberculum approach for the resection of a large suprasellar craniopharyngioma. Design  Single-case-based operative video. Setting  Tertiary center with dedicated skull base team. Participants  A 72-year-old male patient diagnosed with a suprasellar craniopharyngioma. Main Outcomes Measured  Surgical resection of the tumor and preservation of the normal surrounding neurovascular structures. Results  A 72-year-old male patient presented with a 1-year history of progressive bitemporal visual loss. He also referred symptoms suggestive of hypogonadism. Neurological examination was unremarkable and endocrine workup demonstrated mildly elevated prolactin levels. Magnetic resonance images demonstrated a large solid-cystic suprasellar lesion, consistent with the diagnosis of craniopharyngioma. The lesion was retrochiasmatic, compressed the optic chiasm, and extended into the interpeduncular cistern ( Fig. 1 ). Because of that, the patient underwent an endoscopic endonasal transplanum transtuberculum approach. 1 2 3 The nasal stage consisted of a transnasal transseptal approach, with complete preservation of the patient's left nasal cavity. 4 The cystic component of the tumor was decompressed and its solid part was resected. It was possible to preserve the surrounding normal neurovascular structures ( Fig. 2 ). Skull base reconstruction was performed with a dural substitute, a fascia lata graft, and a right nasoseptal flap ( Video 1 ). The patient did well after surgery and referred complete visual improvement. However, he also presented pan-hypopituitarism on long-term follow-up. Conclusions  The endoscopic endonasal route is a good alternative for the resection of suprasellar lesions. It permits tumor resection and preservation of the surrounding neurovascular structures while avoiding external incisions and brain retraction. The link to the video can be found at: https://youtu.be/zmgxQe8w-JQ .

Paraneoplastic limbic encephalitis with associated hypothalamitis mimicking a hyperdense hypothalamic tumor: a case report

International Nuclear Information System (INIS)

Bataduwaarachchi, Vipula R.; Tissera, Nirmali

2016-01-01

a patient with computed tomographic evidence of a central hyperdensity surrounded by bitemporal hypodensities. This pattern of identification will be useful for early diagnosis in resource-poor settings

Migraine pain location in adult patients from eastern India

Directory of Open Access Journals (Sweden)

Chakravarty Ambar

2008-01-01

Full Text Available Background: Sparse literature documenting the location of pain at the onset of migraine attacks and during established headaches is available. Objectives: A prospective study (2003-05 on 800 adult migraine patients (International Classifications of Headache Disorders (ICHD, 2:1.1, 1.2.1 and 1.6.1 was conducted to document (a sites of onset of pain and (b location of pain during established attacks (in> 50% occasions through semistructured interviews. Results: Demography: N = 800; M:F = 144:656 (1:4.56; age, 16-42 years (mean, 26 years; duration of migraine, 1-18 years (mean, 6.8 years. 87% of the subjects were ethnic Bengalis from the eastern Indian state of West Bengal, Calcutta being the capital city. Migraine types (on the basis of> 50% headache spells: N = 800; 1.1:668 (83.5%; 1.2.1:18 (2.25%; 1.6.1:114 (14.25%. Location of pain at onset: Unilateral onset was present in 41.38% of the patients; of these, 53.17% had eye pain; 8.16%, frontal pain and 38.67%, temporal pain. In 32.25% of the patients, bilateral/central location of pain, mostly bitemporal or at vertex was noted. Cervico-occipital pain onset was noted in 26.43% patients (predominantly occipital, 14.68%; predominantly cervical, 11.75%. Location of established headaches: In 47.4% of the patients, with unilateral ocular or temporal onset, pain remained at the same site. Pain became hemicranial in 32.9%. In most patients, unilateral frontal onset pain (55.5% became bilateral or holocranial. Most bilateral ocular (69.4% and temporal onset (69.7% pains remained at the same location. However, most bifrontal (55.6% and vertex onset (56.9% pains subsequently became holocranial. Most occipital pains at onset became holocranial (45.3%, but cervical pains subsequently became either hemicranial (38.3% or holocranial (36.2%. Conclusions: This study documents location of pain at the onset and during established headaches in migraine patients largely from a specific ethnic group. Migraine with

Proton Therapy for Reirradiation of Progressive or Recurrent Chordoma

Energy Technology Data Exchange (ETDEWEB)

McDonald, Mark W., E-mail: mmcdona2@iuhealth.org [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana (United States); Indiana University Health Proton Therapy Center, Bloomington, Indiana (United States); Linton, Okechuckwu R. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana (United States); Shah, Mitesh V. [Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, Indiana (United States)

2013-12-01

Purpose: To report the results in patients reirradiated with proton therapy for recurrent or progressive chordoma, with or without salvage surgery. Methods and Materials: A retrospective review of 16 consecutive patients treated from 2005 to 2012 was performed. All patients had received at least 1 prior course of radiation therapy to the same area, and all but 1 patient had at least 1 surgical resection for disease before receiving reirradiation. At the time of recurrence or progression, half of the patients underwent additional salvage surgery before receiving reirradiation. The median prior dose of radiation was 75.2 Gy (range, 40-79.2 Gy). Six patients had received prior proton therapy, and the remainder had received photon radiation. The median gross tumor volume at the time of reirradiation was 71 cm{sup 3} (range, 0-701 cm{sup 3}). Reirradiation occurred at a median interval of 37 months after prior radiation (range, 12-129 months), and the median dose of reirradiation was 75.6 Gy (relative biological effectiveness [RBE]) (range. 71.2-79.2 Gy [RBE]), given in standard daily fractionation (n=14) or hyperfractionation (n=2). Results: The median follow-up time was 23 months (range, 6-63 months); it was 26 months in patients alive at the last follow-up visit (range, 12-63 months). The 2-year estimate for local control was 85%, overall survival 80%, chordoma-specific survival 88%, and development of distant metastases 20%. Four patients have had local progression: 3 in-field and 1 marginal. Late toxicity included grade 3 bitemporal lobe radionecrosis in 1 patient that improved with hyperbaric oxygen, a grade 4 cerebrospinal fluid leak with meningitis in 1 patient, and a grade 4 ischemic brainstem stroke (out of radiation field) in 1 patient, with subsequent neurologic recovery. Conclusions: Full-dose proton reirradiation provided encouraging initial disease control and overall survival for patients with recurrent or progressive chordoma, although additional

Proton Therapy for Reirradiation of Progressive or Recurrent Chordoma

International Nuclear Information System (INIS)

McDonald, Mark W.; Linton, Okechuckwu R.; Shah, Mitesh V.

2013-01-01

Purpose: To report the results in patients reirradiated with proton therapy for recurrent or progressive chordoma, with or without salvage surgery. Methods and Materials: A retrospective review of 16 consecutive patients treated from 2005 to 2012 was performed. All patients had received at least 1 prior course of radiation therapy to the same area, and all but 1 patient had at least 1 surgical resection for disease before receiving reirradiation. At the time of recurrence or progression, half of the patients underwent additional salvage surgery before receiving reirradiation. The median prior dose of radiation was 75.2 Gy (range, 40-79.2 Gy). Six patients had received prior proton therapy, and the remainder had received photon radiation. The median gross tumor volume at the time of reirradiation was 71 cm 3 (range, 0-701 cm 3 ). Reirradiation occurred at a median interval of 37 months after prior radiation (range, 12-129 months), and the median dose of reirradiation was 75.6 Gy (relative biological effectiveness [RBE]) (range. 71.2-79.2 Gy [RBE]), given in standard daily fractionation (n=14) or hyperfractionation (n=2). Results: The median follow-up time was 23 months (range, 6-63 months); it was 26 months in patients alive at the last follow-up visit (range, 12-63 months). The 2-year estimate for local control was 85%, overall survival 80%, chordoma-specific survival 88%, and development of distant metastases 20%. Four patients have had local progression: 3 in-field and 1 marginal. Late toxicity included grade 3 bitemporal lobe radionecrosis in 1 patient that improved with hyperbaric oxygen, a grade 4 cerebrospinal fluid leak with meningitis in 1 patient, and a grade 4 ischemic brainstem stroke (out of radiation field) in 1 patient, with subsequent neurologic recovery. Conclusions: Full-dose proton reirradiation provided encouraging initial disease control and overall survival for patients with recurrent or progressive chordoma, although additional toxicities may

Pneumatocele selar a tensión: Reporte de un caso y revisión de la literatura

Science.gov (United States)

Campero, Álvaro; Ajler, Pablo; Goldschmidt, Ezequiel; Bendersky, Damián; Campero, Abraham

2012-01-01

Introducción: El neumoencéfalo a tensión luego de la cirugía transesfenoidal es poco común. En la literatura existen pocos casos reportados en los cuales el aire se encuentra localizado exclusivamente en las regiones selar y supraselar, constituyendo un pneumatocele selar. En este artículo se describe un caso inusual de pneumatocele selar a tensión de presentación tardía. Descripción del caso: Una mujer de 57 años consultó por hemianopsia bitemporal. Previamente, ya se le había realizado una cirugía transnasal por un adenoma hipofisario y se le había colocado una derivación lumbo-peritoneal por la presencia de una fístula de líquido cefalorraquídeo. Además, se le había realizado una resección transcraneal de un componente intracavernoso del tumor y radiocirugía debido a la agresividad del mismo. Se llevó a cabo una resonancia magnética que demostró un pneumatocele selar y supraselar. Intervención: Se realizó un abordaje transciliar. La región selar estaba encapsulada por tejido cicatrizal debido a los procedimientos previos. Se abrió la cicatriz y el aire fue evacuado. Posteriormente, el piso selar fue cerrado con grasa y cola de fibrina. Despuós del procedimiento, su campo visual retornó a la normalidad. Un año después de su última cirugía, continua asintomática. Conclusión: El pneumatocele selar y supraselar a tensión es un hallazgo extremadamente raro luego de una cirugía transesfenoidal. Su manifestaciónw clínica sería la alteración visual debida a la compresión inferior de la vía óptica. El pneumatocele selar a tensión debe ser evacuado en un corto plazo. PMID:23596554

Prévenir le risque infectieux à l’hôpital ? Preventing the infection risk in hospital?Anthropological reflections on hospital hygiene in a medical ward in Niger

Directory of Open Access Journals (Sweden)

Eugénie d’Alessandro

2012-05-01

Full Text Available En Afrique, la maîtrise du risque infectieux en milieu hospitalier reste une question cruciale. Bien souvent, les analyses se limitent à une évaluation des décalages entre des normes techniques et des pratiques hospitalières. L’insuffisance des connaissances théoriques est régulièrement invoquée, conduisant à un cycle de formation-évaluation qui semble largement voué à l’échec. Une approche anthropologique peut aider à la résolution de ces problèmes. En proposant une lecture des dimensions sociales et culturelles des risques sanitaires, le rôle de l’anthropologue est d’élargir la compréhension de ces dysfonctionnements. Il s’agit de penser l’hôpital comme un espace où s’articulent diverses dimensions sociales, éthiques, médicales et techniques. Témoignant de cet apport complémentaire dans le champ de la santé, de nouvelles pistes émergent d’une enquête menée à l’Hôpital National de Niamey. D’abord, la superposition d’espaces techniques et sociaux se traduit par une confusion dans les gestes. Les obligations sociales brouillent alors les chaînes gestuelles techniques. Ensuite, la prégnance d’un héritage historique définit un certain mode de délivrance des biens publics dont les manifestations se retrouvent dans le quotidien d’un hôpital. Enfin, des « mondes sensibles » différents et les normes techniques élaborées dans le contexte de la médecine moderne deviennent des abstractions en l’absence de correspondances perceptives. Ici, l’anthropologie jette un pont interdisciplinaire entre les préoccupations de santé publique et les questions d’économie morale et décisionnelle.In Africa, controlling infectious diseases in hospitals remains a major issue. So far, most analyses have assessed the gap between technical norms and hospital practices. These surveys commonly enlighten a lack of theoretical knowledge and, therefore, come up with cycles of training-assessing which

Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy.

Science.gov (United States)

Keller, Simon S; Glenn, G Russell; Weber, Bernd; Kreilkamp, Barbara A K; Jensen, Jens H; Helpern, Joseph A; Wagner, Jan; Barker, Gareth J; Richardson, Mark P; Bonilha, Leonardo

2017-01-01

Approximately one in every two patients with pharmacoresistant temporal lobe epilepsy will not be rendered completely seizure-free after temporal lobe surgery. The reasons for this are unknown and are likely to be multifactorial. Quantitative volumetric magnetic resonance imaging techniques have provided limited insight into the causes of persistent postoperative seizures in patients with temporal lobe epilepsy. The relationship between postoperative outcome and preoperative pathology of white matter tracts, which constitute crucial components of epileptogenic networks, is unknown. We investigated regional tissue characteristics of preoperative temporal lobe white matter tracts known to be important in the generation and propagation of temporal lobe seizures in temporal lobe epilepsy, using diffusion tensor imaging and automated fibre quantification. We studied 43 patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis and 44 healthy controls. Patients underwent preoperative imaging, amygdalohippocampectomy and postoperative assessment using the International League Against Epilepsy seizure outcome scale. From preoperative imaging, the fimbria-fornix, parahippocampal white matter bundle and uncinate fasciculus were reconstructed, and scalar diffusion metrics were calculated along the length of each tract. Altogether, 51.2% of patients were rendered completely seizure-free and 48.8% continued to experience postoperative seizure symptoms. Relative to controls, both patient groups exhibited strong and significant diffusion abnormalities along the length of the uncinate bilaterally, the ipsilateral parahippocampal white matter bundle, and the ipsilateral fimbria-fornix in regions located within the medial temporal lobe. However, only patients with persistent postoperative seizures showed evidence of significant pathology of tract sections located in the ipsilateral dorsal fornix and in the contralateral parahippocampal white matter bundle

Intensive time series data exploitation: the Multi-sensor Evolution Analysis (MEA) platform

Science.gov (United States)

Mantovani, Simone; Natali, Stefano; Folegani, Marco; Scremin, Alessandro

2014-05-01

The monitoring of the temporal evolution of natural phenomena must be performed in order to ensure their correct description and to allow improvements in modelling and forecast capabilities. This assumption, that is obvious for ground-based measurements, has not always been true for data collected through space-based platforms: except for geostationary satellites and sensors, that allow providing a very effective monitoring of phenomena with geometric scale from regional to global; smaller phenomena (with characteristic dimension lower than few kilometres) have been monitored with instruments that could collect data only with a time interval in the order of several days; bi-temporal techniques have been the most used ones for years, in order to characterise temporal changes and try identifying specific phenomena. The more the number of flying sensor has grown and their performance improved, the more their capability of monitoring natural phenomena at a smaller geographic scale has grown: we can now count on tenth of years of remotely sensed data, collected by hundreds of sensors that are now accessible from a wide users' community, and the techniques for data processing have to be adapted to move toward a data intensive exploitation. Starting from 2008, the European Space Agency has initiated the development of the Multi-sensor Evolution Analysis (MEA) platform (https://mea.eo.esa.int), whose first aim was to permit the access and exploitation of long term remotely sensed satellite data from different platforms: 15 years of global (A)ATSR data together with 5 years of regional AVNIR-2 data were loaded into the system and were used, through a web-based graphic user interface, for land cover change analysis. The MEA data availability has grown during years integrating multi-disciplinary data that feature spatial and temporal dimensions: so far tenths of Terabytes of data in the land and atmosphere domains are available and can be visualized and exploited, keeping the

Patpong, entre sexe et commerce.

Directory of Open Access Journals (Sweden)

Sébastien Roux

2010-03-01

Full Text Available Le tourisme dit « sexuel » est aujourd’hui décrié comme une forme de tourisme international immoral, un dysfonctionnement grave de la mondialisation appelant une réaction politique contre « l’exploitation sexuelle » dont seraient victimes des millions de femmes et d’enfants. Pourtant, derrière l’apparente évidence du « tourisme sexuel » comme expression de sens commun, rares sont les enquêtes qui explicitent la réalité concrète des échanges prostitutionnels. En adoptant une démarche ethnographique, l’article décrit le fonctionnement de Patpong, un quartier rouge de Bangkok dédié à une clientèle internationale. Par la description des offres disponibles, des revenus générés, des codes et des pratiques, la complexité de l’espace réapparaît. Il s’agit de donner à voir la réalité des échanges pour interroger l’articulation entre commerce et sexualité. L’analyse ethnographique du tourisme sexuel permet ainsi de souligner la diversité des pratiques et de rappeler que les formes les plus visibles — et les plus commentées — d’échanges prostitutionnels éclipsent trop souvent une pluralité d’expériences qui participe pourtant au succès de ces ruelles mondialement connues. So-called sex tourism is condemned as an immoral form of international tourism, a serious failure of globalization requiring political action against the “sexual exploitation” suffered by millions of women and children. Yet behind the common and seemingly evident understanding of “sexual tourism,” few studies have focused on the actual reality of such relations. Based on an ethnographic study, this article presents the structure of Patpong, a red-light district of Bangkok dedicated to international tourism. First, the article aims to briefly present the historical development of Patpong. This peculiar space is intrinsically linked to sex tourism, as these world-renowned streets expanded since the mid-60s to

Fostering Effective Studying and Study Planning with Study Questions

Science.gov (United States)

Wilhelm, Pascal; Pieters, Jules M.

2007-01-01

In a course on biological psychology and neuropsychology, study questions were provided that also appeared as test questions in the course exam. This method was introduced to support students in active processing and reproduction of the study texts, and study planning. Data were gathered to test the hypothesis that study question use would be…

Fostering effective studying and study planning with study questions

NARCIS (Netherlands)

Wilhelm, P.; Pieters, J.M.

2007-01-01

In a course on biological psychology and neuropsychology, study questions were provided that also appeared as test questions in the course exam. This method was introduced to support students in active processing and reproduction of the study texts, and study planning. Data were gathered to test the

Dynamique de changement de l’arganeraie entre sur-usage et mutations sociales : une opportunité d’équilibre socio-écologique ?

Directory of Open Access Journals (Sweden)

Farid El Wahidi

2014-12-01

Full Text Available Detecting and characterizing forest cover change over time is the first step towards the identification of driving forces and understanding their mechanisms. Using remote sensing data and socio-economic surveys, this work tries to understand man-environment interactions in the Haha argan forest (14.7 % of the entire Moroccan argan forest. It consists, in a first step, on detecting and characterizing forest cover changes. The second step seeks to link the estimated change to specific factors from the analysis of traditional land management and demographic, socio-economic dynamics in the study area. The obtained results contribute to clarify the ambiguous speech around the argan forest degradation, at least in the mountain and along the Atlantic band. It implies a small rate of decline in forest area, barely exceeding a rate of 0.2% between 1993 and 2006. As for the stumps density, it almost does not decrease (averaging 0.6 stump/ha between 1984 and 2006. These changes, often subtle, are observed in 96.5% in the common area (mouchaa for free use and not submitted to the traditional land management regulation (agdals set by the local community. The Haha argan forest is experiencing a long-term of ecological dynamic change corollary to a demographic, social and economic dynamics so called favorable to its preservation. Nevertheless, it suffers from a qualitative degradation and a dysfunction of natural processes limiting any restoration dynamic and making questionable the reliability and the sustainability of this agro-ecosystem. Détecter et caractériser les changements du couvert forestier au fil du temps est la première étape vers l'identification des forces motrices et la compréhension de leurs mécanismes. Ce travail consiste, en combinant données de télédétection et enquêtes socio-économiques, à construire une image de l’ensemble des interactions homme-environnement autour de l’arganeraie des Haha (sud-ouest marocain. Il s�

HTS Teologiese Studies / Theological Studies

African Journals Online (AJOL)

HTS Teologiese Studies/Theological Studies is an acclaimed Open Access journal with broad coverage that promotes multidisciplinary, religious, and biblical aspects of studies in the international theological arena. The journal's publication criteria are based on high ethical standards and the rigor of the methodology and ...

Asian Studies/Global Studies: Transcending Area Studies and Social Sciences

Directory of Open Access Journals (Sweden)

John Lie

2012-03-01

Full Text Available The post–World War II growth of area studies, and Asian studies in particular, posed a serious challenge to the mainstream social sciences. Yet the epistemic and institutional foundations of area studies were never well articulated or justified, and the post–Cold War years brought a pervasive sense of crisis to its intellectual mission and justification. In particular, the author focuses on the tensions, if not contradictions, between social science disciplines and area studies. In advocating a more integrated human science, which depends more on mobile networks of scholars than on fixed fields of discipline-bound professors, the author suggests global studies as a fitting field of inquiry in the age of globalization.

Archives: HTS Teologiese Studies / Theological Studies

African Journals Online (AJOL)

Items 1 - 50 of 120 ... Archives: HTS Teologiese Studies / Theological Studies. Journal Home > Archives: HTS Teologiese Studies / Theological Studies. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Journal Home · ABOUT THIS JOURNAL · Advanced Search ...

The Evaluation of Study Success between Online Study and Classroom Study Environment

Directory of Open Access Journals (Sweden)

Singkhamfu Phudinan

2016-01-01

Full Text Available Online study has increasingly become more attractive to students at university level due to convenience access to their instructors and to study resources. This study has developed online social network for study. It proposes to provide lesson content availability, past lecture, by sending online study lesson media to students’ mobile phone or tablet. Approximately 85 undergraduate software engineering students participated for 1.5 semesters. In comparing the use of the study toll, and without the tool, the alterations were found between traditional classroom learning style and online study. Also, the study’s aim was to attest the online study tool’s efficiency. However, these results were not obvious when the achievement factor was controlled by the limitation of time. The primary purpose of this study is to evaluate these two groups of students with extended experiment time for a noticeable result by used questionnaires course examination, and inventory of ILP learning process. The observed, shows that students with online study tools scored higher on course examinations after measures by the mentioned methodology.

Case Study: Testing with Case Studies

Science.gov (United States)

Herreid, Clyde Freeman

2015-01-01

This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue discusses using case studies to test for knowledge or lessons learned.

Analyses of the soil surface dynamic of South African Kalahari salt pans based on hyperspectral and multitemporal data

Science.gov (United States)

Milewski, Robert; Chabrillat, Sabine; Behling, Robert; Mielke, Christian; Schleicher, Anja Maria; Guanter, Luis

2016-04-01

The consequences of climate change represent a major threat to sustainable development and growth in Southern Africa. Understanding the impact on the geo- and biosphere is therefore of great importance in this particular region. In this context the Kalahari salt pans (also known as playas or sabkhas) and their peripheral saline and alkaline habitats are an ecosystem of major interest. They are very sensitive to environmental conditions, and as thus hydrological, mineralogical and ecological responses to climatic variations can be analysed. Up to now the soil composition of salt pans in this area have been only assessed mono-temporally and on a coarse regional scale. Furthermore, the dynamic of the salt pans, especially the formation of evaporites, is still uncertain and poorly understood. High spectral resolution remote sensing can estimate evaporite content and mineralogy of soils based on the analyses of the surface reflectance properties within the Visible-Near InfraRed (VNIR 400-1000 nm) and Short-Wave InfraRed (SWIR 1000-2500 nm) regions. In these wavelength regions major chemical components of the soil interact with the electromagnetic radiation and produce characteristic absorption features that can be used to derive the properties of interest. Although such techniques are well established for the laboratory and field scale, the potential of current (Hyperion) and upcoming spaceborne sensors such as EnMAP for quantitative mineralogical and salt spectral mapping is still to be demonstrated. Combined with hyperspectral methods, multitemporal remote sensing techniques allow us to derive the recent dynamic of these salt pans and link the mineralogical analysis of the pan surface to major physical processes in these dryland environments. In this study we focus on the analyses of the Namibian Omongwa salt pans based on satellite hyperspectral imagery and multispectral time-series data. First, a change detection analysis is applied using the Iterative

The Study of the Relationship between Mother's Studies with Study Skills and Mathematics Performance of Students

Directory of Open Access Journals (Sweden)

Behnoush Taheri

2015-07-01

Full Text Available Certainly teaching study skills of mathematics has special importance and plays important role in mathematics performance of students. As mothers spend more times with self-children then they can be effect on study and their mathematics performance. Present research implements to study of the relationship between mothers' studies with study skills and mathematics performance of their children. Population of this research is all girl students of first grade in high school at zone one of Tehran and sample is 97 people. For collecting data of this research through standard questionnaire of mathematics studies skills is used for measuring of study skill of mathematics and questions for studying information related to mothers' studies and a math exam for getting information of mathematics performance of students are used. The results indicated that there is not significant relationship between mothers' studies and study skill of mathematics among students. Also, it is indicated that there is positive significant relationship between mothers' studies and mathematic performance of students.

Study of lip prints: A forensic study

Directory of Open Access Journals (Sweden)

Vikash Ranjan

2014-01-01

Full Text Available Background: Although several studies have been done on lip prints for human identification in forensic science, there is a doubt about their use in gender determination. Aims: The present study was designed to study the lip groove patterns in all the quadrants of both male and female subjects to identify the sex, based on the patterns of the grooves of the lip prints. Study Design: 300 lip prints were collected from volunteers of D. J. College of Dental Sciences and Research, Modinagar (UP. Materials and Methods: Lip prints were recorded with lip stick and transferred on to a glass slide. Statistical Analysis: Pearson chi-square test was adopted for statistical analysis and probability value (P value was calculated. Conclusion: In our study, none of the lip prints were identical, thus confirming the role of lip prints in individual identification. According to Suzuki′s classification, Type I, II, III and IV patterns were significant in gender determination.

Prospective regional studies: The Rhine Meuse study and the Tennessee Valley study

International Nuclear Information System (INIS)

Bayer, A.

1980-01-01

Within the scope of this report two regional studies are presented: - the 'Rhein-Maas-Study' within which the expected radiological impact of the population in the Rhein and Maas basin - which is situated within Central Europe - is assessed on the basis of the planned and forecasted development of nuclear energy in the coming decades. - The 'Tennessee Valley Study' within which the expected radiological impact of the population in the Tennessee-Cumberland basis - which is situated within North America - is assessed likewise on the basis of the planned and forecasted development of nuclear energy in the coming decades. (orig./RW)

PILOT STUDY: THE TAMPA ASTHMATIC CHILDREN'S STUDY (TACS)

Science.gov (United States)

The Tampa Asthmatic Children's Study (TACS) was a pilot research study that focused on developing and evaluating air pollution exposure assessment methods and participant recruiting tools for children in the age range of 1-5 years old. The pilot study focused on (a) simple, cost-...

CASE STUDY CRITIQUE; UPPER CLINCH CASE STUDY

Science.gov (United States)

Case study critique: Upper Clinch case study (from Research on Methods for Integrating Ecological Economics and Ecological Risk Assessment: A Trade-off Weighted Index Approach to Integrating Economics and Ecological Risk Assessment). This critique answers the questions: 1) does ...

Repository design sensitivity study: Engineering study report

International Nuclear Information System (INIS)

1987-01-01

A preliminary sensitivity study of the salt repository design has been performed to identify critical site and design parameters to help guide future site characterization and design optimization activities. The study considered the SCP-conceptual design at the Deaf Smith County site in Texas with the horizontal waste package emplacement mode as the base case. Relative to this base case, parameter variations were compared. Limited studies were performed which considered the vertical emplacement mode geometry. The report presents the reference data base and design parameters on which the study was based (including the range of parameters that might be expected). Detailed descriptions of the numerical modeling methods and assumptions are included for the thermal, thermomechanical and hydrogeological analyses. The impacts of parameter variations on the sensitivity of the rock mass response are discussed. Recommendations are provided to help guide site characterization activities and advanced conceptual design optimization activities. 47 refs., 119 refs., 22 tabs

Paradigms for subdural grids' implantation in patients with refractory epilepsy Paradigmas para implante de placas subdurais em pacientes com epilepsia refratária

Directory of Open Access Journals (Sweden)

ARTHUR CUKIERT

2000-09-01

Full Text Available RATIONALE: The need for invasive monitoring in patients with refractory epilepsy has been greatly reduced by the introduction of new technologies such as PET, SPECT and MRI in the clinical practice. On the other hand, 10 to 30% of the patients with refractory epilepsy have non-localizatory non-invasive preoperative work-up results. This paper reports on the paradigms for subdural electrodes implantation in patients with different refractory epileptic syndromes. METHODS: Twenty-nine adult refractory epileptic patients were studied. Patients were divided into five different epileptic syndromes that represented the majority of the patients who needed invasive recordings: bitemporal (Group I; n=16 , bi-frontal-mesial (Group II, n=5, hemispheric (Group III; n=2, anterior quadrant (Group IV; n=3 and posterior quadrant (Group V; n=3. All of them were submitted to extensive subdural electrodes' implantation (from 64 to 160 contacts covering all the cortical surface potentially involved in epileptogenesis under general anesthesia. Results: All patients tolerated well the procedure. There was no sign or symptom of intracranial hypertension except for headache in 22 patients. In all except one Group II patient, prolonged electrocorticographic monitoring using the described subdural cortical coverage patterns was able to define a focal area amenable for resection. In all Groups II-V patients cortical stimulation was able to adequately map the rolandic and speach areas as necessary. CONCLUSION: Despite recent technological advances invasive neurophysiological studies are still necessary in some patients with refractory epilepsy. The standardization of the paradigms for subdural implantation coupled to the study of homogeneous patients' populations as defined by MRI will certainly lead to a better understanding of the pathophysiology involved in such cases and an improved surgical outcome.INTRODUÇÃO: O advento de novas tecnologias de imagem tais como o PET

German Studies in America. German Studies Notes.

Science.gov (United States)

Sander, Volkmar; Osterle, Heinz D.

This volume contains two papers, "German Studies in America," by Volkmar Sander, and "Historicism, Marxism, Structuralism: Ideas for German Culture Courses," by Heinz D. Osterle. The first paper discusses the position of German studies in the United States today. The greatest challenge comes from low enrollments; therefore,…

WWC Study Review Guide: Group Design Studies

Science.gov (United States)

What Works Clearinghouse, 2018

2018-01-01

Underlying all What Works Clearinghouse (WWC) products are WWC Study Review Guides, which are intended for use by WWC certified reviewers to assess studies against the WWC evidence standards. As part of an ongoing effort to increase transparency, promote collaboration, and encourage widespread use of the WWC standards, the Institute of Education…

Social Studies Education and a New Social Studies Movement

Directory of Open Access Journals (Sweden)

Bulent Tarman

2010-05-01

Full Text Available The aim of this article is to analyze theoretically the need to improve Social Studies Education in Turkey in a pedagogical manner and on the basis of the intended contributions and goals of a New Social Studies Movement to the field.Social Studies Education is an important teaching discipline to equip individuals with the necessary knowledge, skills, values and attitudes to operate efficiently in a knowledge society.The New Social Studies movement of 1960s in the USA contributed to the development of Social Studies Education.This movement tried to establish a constructivist approach. They emphasized on the importance of an inquiry based approach, and rich and real life situation in the classrooms and skills such as critical thinking, reflective thinking, cooperation and collaboration in Social Studies Education. However, the movement diminished in a short while due to the lack of research to support their theoretically sound ideas, appropriate teaching resources for teachers and students and ill-equipped teachers while their ideas were and still are gaining impetus in many countries in the world.Social Studies Education is relatively new in Turkey. Social Studies Education in Turkey has weaknesses in terms of both in theoretically and practically. The quality of teaching resources and materials and teacher qualifications are not up-to-standards to carry out a constructivist Social Studies Education.A new movement has started in Turkey to improve Social Studies Education. This new Social Studies movement aims to do research in the field on the area, print books and teaching resource for both teachers and students, develop policies, hold academic meetings, publish high quality journals for both academics and practitioners, to create opportunities and gateways for networking. This article critically argues the proposed contribution of the new Social Studies movement to the field in Turkey drawing upon the experiences of the movement of 1960s in

Study of the valorisation of thermal storage and of power-to-heat. Study report + Study synthesis

International Nuclear Information System (INIS)

Canal, Patrick; Gerbaud, Manon; Mouret, Sylvain; Chammas, Maxime; Attard, Pierre; Bucy, Jacques de; Lochmann, Hugo; Le Gars, Loic; Payen, Luc; Lesueur, Herve

2016-11-01

This study aimed at assessing the potential of thermal storage and of power-to-heat in France, and at identifying relevant technological sectors by 2030. In order to do so, the study aimed at quantifying the value of these sectors for applications considered as relevant, this value lying in the valorisation of heat or electric power excesses, in the power arbitration, and in investment savings. Analyses have have been performed on case studies through an assessment of storage value and of P2H (Power-to-Heat) for the collectivity, a joint optimisation of fleet sizing and management, a modelling of power system fundamentals, an analysis of the profitability of storage and P2H projects, and an assessment of the technical source and of the impact on jobs. Thus, after an overview of thermal storage and power-to-heat technologies, and a presentation of the adopted methodology (definition of case studies, case study methodology, modelling hypotheses related to production and consumption, and modelling of the power system), the authors report the study of the sizing of biomass boilers in an urban heat network (determination of the storage value for the community), the study of development of an urban heat network (storage value for the community and for the operator, technological perspective by 2030), the study of the use of power-to-heat and storage for an urban heat network (value for the community, profitability and business model, perspective by 2030), the study of unavoidable heat recovery on an industrial site (value, profitability and business model, perspective by 2030), the study of co-generation and thermal storage on an industrial site (value, impact on income), the study of domestic thermal storage and of the flexibility of the French electric power system (impact of thermal water heaters on the flexibility), and the study of the impact on employment (jobs related to the domestic market and to the development of an exporting sector). Appendices propose sheets

Clinical Studies

DEFF Research Database (Denmark)

Pallesen, Ulla

universities and practicing dentists restore millions of teeth throughout the World with composite resin materials. Do we know enough about the clinical performance of these restorations over time? Numerous in vitro studies are being published on resin materials and adhesion, some of them attempting to imitate...... in vivo conditions. But real life is different and in vitro studies cannot include all variables. Only clinical studies can provide valid information on the clinical performance of restorations over time. What do we know about longevity of posterior resin restorations? What are the reasons for replacement...... and results from own up to 30-year prospective clinical university studies and practice based studies from Public Dental Health Service on the clinical performance of posterior composite resin restorations....

Initial Study

DEFF Research Database (Denmark)

Torp, Kristian

2009-01-01

increased. In the initial study presented here, the time it takes to pass an intersection is studied in details. Two major signal-controlled four-way intersections in the center of the city Aalborg are studied in details to estimate the congestion levels in these intersections, based on the time it takes...

Game Studies

NARCIS (Netherlands)

Raessens, J.F.F.

2016-01-01

This entry describes game studies as a dynamic interdisciplinary field of academic study and research that focuses on digital games and play in a wide variety of social and cultural contexts. It examines the history of game studies from its prehistory, when games were looked at as part of other

Study protocol

DEFF Research Database (Denmark)

Thorsteinsson, Troels; Helms, Anne Sofie; Adamsen, Lis

2013-01-01

, and problems related to interaction with peers. Methods/design The RESPECT study is a nationwide population-based prospective, controlled, mixed-methods intervention study looking at children aged 6-18 years newly diagnosed with cancer in eastern Denmark (n = 120) and a matched control group in western Denmark......, and one year after the cessation of treatment. The study is powered to quantify the impact of the combined educational, physical, and social intervention programs. Discussion RESPECT is the first population-based study to examine the effect of early rehabilitation for children with cancer, and to use...

Urban Studies: A Study of Bibliographic Access and Control.

Science.gov (United States)

Anderson, Barbara E.

This paper analyzes: (1) the bibliographic access to publications in urban studies via printed secondary sources; (2) development and scope of classification systems and of vocabulary control for urban studies; and (3) currently accessible automated collections of bibliographic citations. Urban studies is defined as "an agglomeration of…

Standardisation And Validation Study Of A New Study Skills ...

African Journals Online (AJOL)

Concerns have also been raised by various researchers about the latent constructs of existing western scales to assess study skills. The objective of this study was to develop, standardize and validate a culturally sensitive study skills questionnaire (SSQ). Methods: a stratified random sample of secondary school students (n ...

Civilian End Strength Study. Study Sponsor ODCSLOG.

Science.gov (United States)

1985-12-30

Chief of Staff deferred action on the recommendations and requested a subsequent briefing with the following guidance. (1) Need to do more to take...Term Actions ... ..................... 38-39 ix CIVILIAN END STRENGTH STUDY Abstract This study examined the methodology by which the Army determines...DAPE-MBC) and COA ( DACA -OMP) has facilitated this process; an updated LOI, in draft, will clear up some of the problems identified in the test

[Vestibular compensation studies]. [Vestibular Compensation and Morphological Studies

Science.gov (United States)

Perachio, Adrian A. (Principal Investigator)

1996-01-01

The following topics are reported: neurophysiological studies on MVN neurons during vestibular compensation; effects of spinal cord lesions on VNC neurons during compensation; a closed-loop vestibular compensation model for horizontally canal-related MVN neurons; spatiotemporal convergence in VNC neurons; contributions of irregularly firing vestibular afferents to linear and angular VOR's; application to flight studies; metabolic measures in vestibular neurons; immediate early gene expression following vestibular stimulation; morphological studies on primary afferents, central vestibular pathways, vestibular efferent projection to the vestibular end organs, and three-dimensional morphometry and imaging.

Southeastern Cancer Study Group: breast cancer studies

International Nuclear Information System (INIS)

Smalley, R.V.; Bartolucci, A.A.; Moore, M.

1983-01-01

During the past 10 years, the Southeastern Cancer Study Group (SECSG) has been engaged in one major adjuvant study and three major advanced disease studies for patients with adenocarcinoma of the breast. The adjuvant study is demonstrating that six months of adjuvant CMF is the therapeutic equivalent of 12 months and that post-operative irradiation is of no added therapeutic benefit. In patients with advanced disease, a low dose 5 drug combination of CMFVP induces more objective responses than single agent 5FU, but improves survival only for those patients with liver metastases when compared to the sequential use of the same 5 single agents. The three drug combination, CAF, utilizing doxorubicin, induces more objective responses than low dose CMFVP, but it does not improve overall survival. The addition of a phase active combination, CAMELEON, (i.e., sequentially alternating therapy) of CAF has not improved the duration of disease control and survival for patients with liver metastases, lymphangitic and nodular lung metastases compared to CAF. Aggressive combination chemotherapeutic approaches to patients with advanced disease provide better and longer disease and tumor control but only marginal improvements in overall survival. Adding additional agents to a maximally tolerable regimen has not improved the therapeutic outcome

Deep Attack Weapons Mix Study (DAWMS) Case Study

National Research Council Canada - National Science Library

Bexfield, James

2001-01-01

.... This report describes the process used to conduct the Deep Attack Weapons Mix Study (DAWMS) in 1995-1997. This case study focuses on the weapons being procured by the Services and whether a joint viewpoint would result in a more effective mix...

Absorption studies

International Nuclear Information System (INIS)

Ganatra, R.D.

1992-01-01

Absorption studies were once quite popular but hardly anyone does them these days. It is easier to estimate the blood level of the nutrient directly by radioimmunoassay (RIA). However, the information obtained by estimating the blood levels of the nutrients is not the same that can be obtained from the absorption studies. Absorption studies are primarily done to find out whether some of the essential nutrients are absorbed from the gut or not and if they are absorbed, to determine how much is being absorbed. In the advanced countries, these tests were mostly done to detect pernicious anaemia where vitamin B 12 is not absorbed because of the lack of the intrinsic factor in the stomach. In the tropical countries, ''malabsorption syndrome'' is quire common. In this condition, several nutrients like fat, folic acid and vitamin B 12 are not absorbed. It is possible to study absorption of these nutrients by radioisotopic absorption studies

Critical Kinship Studies

DEFF Research Database (Denmark)

In recent decades the concept of kinship has been challenged and reinvigorated by the so-called “repatriation of anthropology” and by the influence of feminist studies, queer studies, adoption studies, and science and technology studies. These interdisciplinary approaches have been further...... developed by increases in infertility, reproductive travel, and the emergence of critical movements among transnational adoptees, all of which have served to question how kinship is now practiced. Critical Kinship Studies brings together theoretical and disciplinary perspectives and analytically sensitive...... in the Humanities and Social Sciences today. Critical Kinship Studies should be of particular interest to students and scholars in Anthropology, Sociology, Cultural Studies, Medical Humanities, Politics, Gender and Queer Studies and Globalization....

The extended teamwork 2004/2005 exploratory study. Study plan

International Nuclear Information System (INIS)

Skjerve, Ann Britt; Strand, Stine; Skraaning, Gyrd Jr.; Nihlwing, Christer; Helgar, Stein; Olsen, Asle; Kvilesjoe, Hans Oeyvind; Meyer, Geir; Droeivoldsmo, Asgeir; Svengren, Haakan

2005-09-01

The report documents the study plan for the Extended Teamwork 2004/2005 exploratory study, which is performed within the Extended Teamwork HRP research program. The purpose of the research program is to generate ideas on how teamwork in nuclear power plants may be affected by the introduction of new operational concepts. The Extended Teamwork 2004/2005 exploratory study contributes with empirical knowledge on the effect of a new operational concept, implying increased automation levels, changed operator roles, redefined competence requirements to the operators, and new technologies to support co-operation, on teamwork. The Extended Teamwork 2004/2005 exploratory study covered occurrences during the early transition phase, i.e., from the time the operators are introduced to the possible future operational environment, to the time they have completed the twelve scenarios comprised by the study. The study assessed how familiarity with operation in the possible future operational environment may affect the extent and quality of co-operation. The report accounts for the motivation for performing the exploratory study, and explains the research question. It describes the theoretical approach, which is based on Co-operation Theory, the human-centered automation approach, and theories on co-operation across distances, and introduces the concept extended teamwork. It also describes the method applied: it provides a detailed description of the possible future operational environment, including requirements with respect to autonomy and authority - both for humans and for automatic agents, and describes the technology applied to support co-operation in the control-room team. In addition, all measurement techniques applied in the study are accounted for (system logs, questionnaires, interviews, etc.). (Author)

Studies on education for radiation and courses of study (2009)

International Nuclear Information System (INIS)

Sakuraba, Kazuhiro; Nakamura, Hideo; Ukai, Mitsuko

2009-01-01

The Courses of Study are provided as the standards for educational courses in all schools in Japan. The new Courses of Study have been started this year. In this research, we revealed the ways how to teach radiation using the Courses of Study (2009). Education for radiation was first opened for the third grade of secondary school children. The contents in terms of radiation education in this Courses of Study (2009) are the characterization and application of radiation. To promote this new study courses, the knowledge about radiation of young man and woman were also studied. We concluded it is necessary to start radiation education from elementary school. Furthermore to apply the Courses of Study effectively, we need the comments on radiation education from the researcher of radiation. After the comments, teachers are able to make precise educational materials for their own children. (author)

Case-Control Studies - An Efficient Observational Study Design

NARCIS (Netherlands)

van Stralen, Karlijn J.; Dekker, Friedo W.; Zoccali, Carmine; Jager, Kitty J.

2010-01-01

Case-control studies are an efficient research method for investigating risk factors of a disease. The method involves the comparison of the odds of exposure in a patient group with that of the odds of exposure in a control group. As only a minority of the population is included in the study, less

Multivariate Meta-Analysis of Genetic Association Studies: A Simulation Study.

Directory of Open Access Journals (Sweden)

Binod Neupane

Full Text Available In a meta-analysis with multiple end points of interests that are correlated between or within studies, multivariate approach to meta-analysis has a potential to produce more precise estimates of effects by exploiting the correlation structure between end points. However, under random-effects assumption the multivariate estimation is more complex (as it involves estimation of more parameters simultaneously than univariate estimation, and sometimes can produce unrealistic parameter estimates. Usefulness of multivariate approach to meta-analysis of the effects of a genetic variant on two or more correlated traits is not well understood in the area of genetic association studies. In such studies, genetic variants are expected to roughly maintain Hardy-Weinberg equilibrium within studies, and also their effects on complex traits are generally very small to modest and could be heterogeneous across studies for genuine reasons. We carried out extensive simulation to explore the comparative performance of multivariate approach with most commonly used univariate inverse-variance weighted approach under random-effects assumption in various realistic meta-analytic scenarios of genetic association studies of correlated end points. We evaluated the performance with respect to relative mean bias percentage, and root mean square error (RMSE of the estimate and coverage probability of corresponding 95% confidence interval of the effect for each end point. Our simulation results suggest that multivariate approach performs similarly or better than univariate method when correlations between end points within or between studies are at least moderate and between-study variation is similar or larger than average within-study variation for meta-analyses of 10 or more genetic studies. Multivariate approach produces estimates with smaller bias and RMSE especially for the end point that has randomly or informatively missing summary data in some individual studies, when

STUDY OF SECONDARY SCHOOL SOCIAL STUDIES TEACHER UNDERSTANDING ABOUT GEOGRAPHY LITERATION

Directory of Open Access Journals (Sweden)

Sugiyanto Sugiyanto

2017-12-01

Full Text Available This study aims to: (1 know the teacher's understanding about the concept of Geography as a platform in Social Studies learning; (2 know the teacher's understanding about geography literacy as a platform in Social Studies learning; and (3 study the right literacy concept as platform for Social Studies lesson. This research uses survey method. The subjects of the study were Social Studies teachers in Surakarta City. Sampling using startified random sampling. The results showed: 1 76% of respondents do not understand about Geography as a platform in Social Studies learning; 2 80% of respondents have not understood geography literacy; 3 Edelson's geography literature which consist of interaction, interconnection, and implication components can be used as an alternative to the implementation of Geography policy as a Platform in Social Studies.

Creole Studies

DEFF Research Database (Denmark)

This book launches a new approach to creole studies founded on phylogenetic network analysis. Phylogenetic approaches offer new visualisation techniques and insights into the relationships between creoles and non-creoles, creoles and other contact varieties, and between creoles and lexifier...... languages. With evidence from creole languages in Africa, Asia, the Americas, and the Pacific, the book provides new perspectives on creole typology, cross-creole comparisons, and creole semantics. The book offers an introduction for newcomers to the fields of creole studies and phylogenetic analysis. Using...... these methods to analyse a variety of linguistic features, both structural and semantic, the book then turns to explore old and new questions and problems in creole studies. Original case studies explore the differences and similarities between creoles, and propose solutions to the problems of how to classify...

Study Proposal

African Journals Online (AJOL)

MATHEMATICS DEPARTMENT

This cross sectional study design on mathematical syllabi at preparatory levels of the high schools was to ... Technology, Computer Science and Applied Sciences. It is studied of ..... For example, Jimma University Medical faculty students ...

Complicated Intra-Abdominal Infections Observational European study (CIAO Study

Directory of Open Access Journals (Sweden)

Sartelli Massimo

2011-12-01

Full Text Available Abstract Complicated intra-abdominal infections are frequently associated with poor prognoses and high morbidity and mortality rates. Despite advances in diagnosis, surgery, and antimicrobial therapy, mortality rates associated with complicated intra-abdominal infections remain exceedingly high. In order to describe the clinical, microbiological, and management-related profiles of both community-acquired and healthcare-acquired complicated intra-abdominal infections (IAIs, the World Society of Emergency Surgery (WSES, in collaboration with the Surgical Infections Society of Europe (SIS-E and other prominent European surgical societies, has designed the CIAO study. The CIAO study is a multicenter, observational study and will be carried out in various surgical departments throughout Europe. The study will include patients undergoing surgery or interventional drainage for complicated IAI.

European Studies

Directory of Open Access Journals (Sweden)

V. O. Pechatnov

2014-01-01

Full Text Available The study of Western countries and teaching courses on the related subjects have longstanding and established tradition at MGIMO-University. The basis of this brilliant research and teaching tradition was laid down by such academicians as E.V. Tarle and V.G. Trukhanovsky, Professor L.I. Clove, Y. Borisov, F.I. Notovitch, G.L. Rozanov. Their work in 1940-1960's at the Department of World History at MGIMO-University progressed in following directions: France studies, German studies, American studies. The work resulted in a number of monographs and textbooks on modern history and foreign policy of the studied countries and regions. The aim of the publications was dictated by the goal of the Institute - to prepare the specialists in international affairs primarily for practical work. A close relationship with the Foreign Ministry was "binding advantage" sometimes limiting researchers in choosing periods and subjects for the study. At the same time the undisputed advantage and quality of regional studies at MGIMO were strengthened by the practical relevance of research, making it a vital and interesting not only for specialists but also for students and researchers from other research centers. Another characteristic of the tradition is the analysis of foreign policy and diplomacy in a close relationship with the socio-economic and political processes. Such an integrated approach to regional geography also formed largely under the influence of institutional profile designed to train highly skilled and versatile specialists in specific countries and regions with a good knowledge of their languages, history, economics, politics, law and culture. Therefore, scientific and educational-methodical work at MGIMO-University has always relied on a wealth of empirical data and has been focused on the analysis of real-world phenomena and processes, acute problems of foreign countries. Scientific research at MGIMO-University traditionally intertwined with

Club studies

DEFF Research Database (Denmark)

Demant, Jakob Johan; Ravn, Signe; Harder, Sidsel Kirstine

2010-01-01

Club studies are sociological investigations of youth drug use in the social situation of the club. By being present at the club the researcher tries to gain access to a somehow hidden population of drug users who only to a lesser extent perceive their drug use as problematic. In spite of impress......Club studies are sociological investigations of youth drug use in the social situation of the club. By being present at the club the researcher tries to gain access to a somehow hidden population of drug users who only to a lesser extent perceive their drug use as problematic. In spite...... of impressive club studies conducted in both Great Britain and in the United States, it seems that, broadly speaking, previous efforts can be characterized as either very broad and/or quantitative or very particular, sub-cultural and exclusively qualitative. Through a review of these studies, this article...... suggests a mixed-methods approach to club studies that combine quantitative data, qualitative interviews and ethnography conducted in the club space. By introducing the concept of ‘socionautics', this review suggests that the researcher travels into the social landscape of youth, clubs and drugs...

Feasibility study

International Nuclear Information System (INIS)

Gibbs, P.; Kalas, P.

1975-01-01

The feasibility study itself examines the technical, economic and financial implications of a nuclear power station in depth so as to make sure that nuclear power is the right course to take. This means that it is quite an expensive operation and it is to avoid wasting this money that a pre-feasibility study is carried out. This preliminary study should eliminate cases where the electrical system cannot absorb the capacity of a nuclear station of commercial size, where other sources of power such as hydro-electricity, gas or cheap coal would make nuclear obviously uneconomic or where no suitable sites exist. If this first rather simple survey shows that nuclear power is a credible solution to a utilities need for electricity or heat production plant, then the next stage is a full feasibility study. (orig./TK) [de

US country studies program: Results from mitigation studies

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-31

This paper describes the U.S. Country Studies Program which was implemented to support the principles and objectives of the Framework Convention on Climate Change (FCCC). There were three principle objectives in this program: to enhance capabilities to conduct climate change assessments, prepare action plans, and implement technology projects; to help establish a process for developing and implementing national policies and measures; to support principles and objective of the FCCC. As a result, 55 countries are completing studies, more than 2000 analysts engaged in the studies have been trained, and there is a much broader understanding and support for climate change concerns. The article describes experiences of some countries, and general observations and conclusions which are broadly seperated into developed countries and those with economies in transition.

Nursing students motivation toward their studies – a survey study

Directory of Open Access Journals (Sweden)

Nilsson Kerstin EL

2008-04-01

Full Text Available Abstract Background This study focuses on Swedish nursing students' motivation toward their studies during their three year academic studies. Earlier studies show the importance of motivation for study commitment and result. The aim was to analyze nursing students' estimation of their degree of motivation during different semester during their education and to identify reasons for the degree of motivation. Methods A questionnaire asking for scoring motivation and what influenced the degree of motivation was distributed to students enrolled in a nursing programme. 315 students who studied at different semesters participated. Analyzes were made by statistical calculation and content analysis. Results The mean motivation score over all semesters was 6.3 (ranked between 0–10 and differed significantly during the semesters with a tendency to lower score during the 5th semester. Students (73/315 with motivation score 6 reported positive opinions to becoming a nurse (125/234, organization of the programme and attitude to the studies. The mean score value for the motivation ranking differed significantly between male (5.8 and female (6.8 students. Conclusion Conclusions to be drawn are that nursing students mainly grade their motivation positive distributed different throughout their entire education. The main motivation factor was becoming a nurse. This study result highlights the need of understanding the students' situation and their need of tutorial support.

Clean Cities Case Study: Barwood Cab Fleet Study Summary

International Nuclear Information System (INIS)

Whalen, P.

1999-01-01

Barwood Cab Fleet Study Summary is the second in a new series called''Alternative Fuel Information Case Studies,'' designed to present real-world experiences with alternative fuels to fleet managers and other industry stakeholders

Study of cluster headache: A hospital-based study

Directory of Open Access Journals (Sweden)

Amita Bhargava

2014-01-01

Full Text Available Introduction: Cluster headache (CH is uncommon and most painful of all primary headaches, and continues to be managed suboptimally because of wrong diagnosis. It needs to be diagnosed correctly and specifically treated. There are few studies and none from this region on CH. Materials and Methods: To study the detailed clinical profile of CH patients and to compare them among both the genders. Study was conducted at Mahatma Gandhi hospital, Jodhpur (from January 2011to December 2013. Study comprises 30 CH patients diagnosed according to International Headache Society guidelines (ICHD-II. Routine investigations and MRI brain was done in all patients. All measurements were reported as mean ± SD. Categorical variables were compared using the Chi-square test, and continuous variables were compared using Student′s t-test. SPSS for Windows, Version 16.0, was used for statistical analyses with the significance level set at P = 0.05. Results: M: F ratio was 9:1. Age at presentation was from 22-60 years (mean - 38 years. Latency before diagnosis was 3 months-12 years (mean - 3.5 years. All suffered from episodic CH and aura was found in none. Pain was strictly unilateral (right-19, left-11, predominantly over temporal region-18 (60%. Pain intensity was severe in 27 (90% and moderate in 3 (10%. Pain quality was throbbing in 12 (40%. Peak intensity was reached in 5 minutes-30 minutes and attack duration varied from 30 minutes to 3 hours (mean - 2.45 hours. Among autonomic features, conjunctival injection-23 (76.6% and lacrimation-25 (83.3% were most common. Restlessness during episode was found in 80%. CH duration varied from 10 days to 12 weeks. Circadian periodicity for attacks was noted in 24 (80%. Conclusion: Results are consistent with other studies on many accounts, but is different from Western studies with respect to low frequency of family history, chronic CH, restlessness and aura preceeding the attack. Detailed elicitation of history is

The Religious Studies on Peace in Turkey: A Content Analysis Study

Directory of Open Access Journals (Sweden)

İrfan ERDOĞAN

2016-12-01

By means of research findings, it will be clearly seen which themes on peace were mostly studied in Turkey, which methods were used in the studies and distribution of studies by years and so on. Thus, the research will lead the researchers about the theme and the method to eliminate the deficiencies in the field for after studies. Also the tendency of the religious studies on peace will be determined.

Drinking Game Studies

DEFF Research Database (Denmark)

Debus, Michael S.

2016-01-01

The paper examines research on drinking game participation from a game studies ontological perspective, covering definition, classification and problems with the, in the studies implied, underlying ontology of drinking games.......The paper examines research on drinking game participation from a game studies ontological perspective, covering definition, classification and problems with the, in the studies implied, underlying ontology of drinking games....

Studying Sideways

DEFF Research Database (Denmark)

Plesner, Ursula

2011-01-01

inequalities in relation to the people we study. This article argues that not all types of social scientific research interviews benefit from an à priori problematization of power and control, ethics and equality, or emancipation. From a constructivist perspective, the article seeks to displace......, we must cultivate interview methods which cause confrontation and disagreement—not to acknowledge asymmetry but to enhance the quality of research.......One strand of the qualitative interview literature has been concerned with the normative or otherwise problematic implications of studying down or studying up (i.e., interviewing “disadvantaged” people or elites). This interview literature is part of a tradition of taking up the problem of power...

Study habits as predictors of academic performance: a case study of ...

African Journals Online (AJOL)

The study assessed whether study habits predicted the academic performance of students at Zion Girls' Senior High School. One hundred and twelve students in form 2 were the respondents in the study. The Study Habit Survey questionnaire was used for data collection. The data was analyzed by the use of bivariate ...

A Study of State Social Studies Standards for American Indian Education

Science.gov (United States)

Warner, Connor K.

2015-01-01

In this study the author surveys social studies standards from 14 U.S. states seeking to answer: (a) what social studies knowledge about American Indians is deemed essential by those states mandating the development of American Indian Education curricula for all public K-12 students? and (b) at what grade levels is this social studies content…

Comparing toxicologic and epidemiologic studies: methylene chloride--a case study.

Science.gov (United States)

Stayner, L T; Bailer, A J

1993-12-01

Exposure to methylene chloride induces lung and liver cancers in mice. The mouse bioassay data have been used as the basis for several cancer risk assessments. The results from epidemiologic studies of workers exposed to methylene chloride have been mixed with respect to demonstrating an increased cancer risk. The results from a negative epidemiologic study of Kodak workers have been used by two groups of investigators to test the predictions from the EPA risk assessment models. These two groups used very different approaches to this problem, which resulted in opposite conclusions regarding the consistency between the animal model predictions and the Kodak study results. The results from the Kodak study are used to test the predictions from OSHA's multistage models of liver and lung cancer risk. Confidence intervals for the standardized mortality ratios (SMRs) from the Kodak study are compared with the predicted confidence intervals derived from OSHA's risk assessment models. Adjustments for the "healthy worker effect," differences in length of follow-up, and dosimetry between animals and humans were incorporated into these comparisons. Based on these comparisons, we conclude that the negative results from the Kodak study are not inconsistent with the predictions from OSHA's risk assessment model.

Study of deep fracturation of granitic rock mass. Documentary study

International Nuclear Information System (INIS)

Bles, J.L.; Landry, J.

1984-01-01

This documentary study realized with the financial support of the European Communities and the CEA aims at the utilization of available data for the understanding of the evolution of natural fractures in granitic rocks from the surface to deep underground. The Mt Blanc road tunnel, the EDF's Arc-Isere gallerie, the Auriat deep borehole and the Pyrenean rock mass of Bassies are studied because detailed structural and geological studies have been realized these last 20 years. In this study are more particularly analyzed the relationship between small fractures and large faults, evolution with depth of fracture density and direction, consequences of rock decompression and relationship between fracturation and groundwater

The modal study

International Nuclear Information System (INIS)

Cook, J.R.

1988-01-01

The term ''Modal Study'' refers to a research program conducted for the Nuclear Regulatory Commission (NRC) on the level of protection provided by NRC-certified packages during the shipment of spent nuclear fuel form U.S. power reactors. The objective of the study was to examine the response of the packages to actual highway and railway accident conditions. The Modal Study results show that NRC-certified spent fuel casks would perform their safety functions under severe, actual accident conditions. The study also explains how NRC's cask design conditions, which are expressed in engineering terms, relate to actual accident conditions, with which the public is more familiar. The Modal Study, along with other transportation studies, physical testing of casks, and the spent fuel shipment safety record confirm the view that casks provide a high level of public safety during spent fuel transport

Studying Engineering Practice

DEFF Research Database (Denmark)

Buch, Anders

2015-01-01

The study of engineering practices has been the focus of Engineering Studies over the last three decades. Theses studies have used ethnographic and grounded methods in order to investigate engineering practices as they unfold in natural settings - in workplaces and engineering education. However......, engineering studies have not given much attention to conceptually clarifying what should be understood by 'engineering practices' and more precisely account for the composition and organization of the entities and phenomena that make up the practices. This chapter investigates and discusses how a 'practice...... will draw out some methodological consequences and discuss the ramifications of a practice theoretical approach for Engineering Studies....

The Korea Nurses' Health Study: A Prospective Cohort Study.

Science.gov (United States)

Kim, Oksoo; Ahn, Younjhin; Lee, Hea-Young; Jang, Hee Jung; Kim, Sue; Lee, Jung Eun; Jung, Heeja; Cho, Eunyoung; Lim, Joong-Yeon; Kim, Min-Ju; Willett, Walter C; Chavarro, Jorge E; Park, Hyun-Young

2017-08-01

The Korea Nurses' Health Study (KNHS) is a prospective cohort study of female nurses, focusing on the effects of occupational, environmental, and lifestyle risk factors on the health of Korean women. Female registered nurses aged 20-45 years and living in the Republic of Korea were invited to join the study, which began in July 2013. They were asked to complete a web-based baseline survey. The study protocols and questionnaires related to the KNHS are based on the Nurses' Health Study 3 (NHS3) in the United States, although they were modified to reflect the Korean lifestyle. Participants were asked about demographic, lifestyle factors, disease history, occupational exposure, reproductive factors, and dietary habits during their adolescence: Follow-up questionnaires were/will be completed at 6-8 month intervals after the baseline survey. If a participant became pregnant, she answered additional questionnaires containing pregnancy-related information. Among 157,569 eligible female nurses, 20,613 (13.1%) completed the web-based baseline questionnaire. The mean age of the participants was 29.4 ± 5.9 years, and more than half of them were in their 20s. Eighty-eight percent of the participants had worked night shifts as a nurse (mean, 5.3 ± 4.3 nights per month). Approximately 80% of the participants had a body mass index below 23 kg/m 2 . Gastrointestinal diseases were the most prevalent health issues (25.9%). The findings from this prospective cohort study will help to identify the effects of lifestyle-related and occupational factors on reproductive health and development of chronic diseases in Korean women.

Human volunteer studies with non-pharmaceutical chemicals: metabolism and pharmacokinetic studies.

Science.gov (United States)

Wilks, M F; Woollen, B H

1994-06-01

1. Human volunteer studies are an essential part of drug development but their use in the area of non-pharmaceutical chemicals has so far been very limited. Such studies can have considerable value in the assessment and improvement of the safe use of chemicals. 2. Once metabolic pathways and target metabolites have been identified in volunteers this information can be used in studies in the workplace or in the general population. Studies should be performed selectively only if there is both a toxic hazard and a significant exposure potential. In addition, they should only be carried out if the required information cannot be obtained in any other way. 3. Volunteer studies with non-pharmaceuticals have become increasingly acceptable in the light of established international guidelines, no-fault compensation, improvements in study design and technical developments which allow the use of very low dose levels. The final decision on whether to carry out a study must always rest with an independent ethical committee. 4. The practical aspects of the study should be specified in a detailed protocol conforming with the principles of good clinical practice. The safety of volunteers must be of paramount concern throughout. Depending on the nature of the chemical and the study, it may be advisable to carry out studies in a clinical facility where equipment is available for the treatment of any emergencies that might occur. 5. Numerous investigators have now shown that human volunteer studies are ethically acceptable, practicable and yield important information. The risk to volunteers is minimal and this approach can lead to an improved foundation for occupational hygiene standards, more accurate risk assessment and thus better protection of the workforce and the general population.

Invisibility Studies

DEFF Research Database (Denmark)

Invisibility Studies explores current changes in the relationship between what we consider visible and what invisible in different areas of contemporary culture. Contributions trace how these changes make their marks on various cultural fields and investigate the cultural significance of these de......Invisibility Studies explores current changes in the relationship between what we consider visible and what invisible in different areas of contemporary culture. Contributions trace how these changes make their marks on various cultural fields and investigate the cultural significance...... conditioned by physical and social settings that create certain possibilities for visibility and visuality, yet exclude others. The richness and complexity of this cultural framework means that no single discipline or interdisciplinary approach could capture it single-handedly. Invisibility Studies begins...

Prospective SAH Study in Japan, 2005(Prospective SAH Study)

OpenAIRE

塩川, 芳昭; 栗田, 浩樹; 藤井, 清孝; Yoshiaki, SHIOKAWA; Hiroki, KURITA; Kiyotaka, FUJII; 杏林大学脳神経外科; 杏林大学脳神経外科; 北里大学脳神経外科; Department of Neurosurgery, Kyorin University School of Medicine; Department of Neurosurgery, Kyorin University School of Medicine

2009-01-01

To clarify current treatment status of ruptured cerebral aneurysms in Japan, a prospective multicenter observational study on the treatment results for aneurysmal subarachnoid hemorrhage was conducted over calendar year 2005 and final 1-year outcomes were collected. Studied centers were selected from among institutes of committee member of Japanese stroke surgery organization or symposium of vasospasm in Japan. A total of 927 patients were enrolled in this study and treatment policies were le...

Gender Studies transdisziplinär gestalten Designing Trans-Disciplinary Gender Studies

Directory of Open Access Journals (Sweden)

Sigrid Schmitz

2007-07-01

Full Text Available Robin Bauer und Helene Götschel stellen am Beispiel des Curriculum-Projektes „Degendering Science“ Inhalte und Didaktiken für transdisziplinäre Lehrkonzepte vor, um Naturwissenschaften und Gender Studies in einen konstruktiven Dialog zu bringen. Dieses Buch ist mit seinen vielen Beispielen eine Hilfestellung für alle Lehrenden der Gender Studies und es liefert wichtige Anregungen zu aktuellen Herausforderungen und Strategien bei der Institutionalisierung der Gender Studies.On the basis of the curriculum project, “Degendering Science,” Robin Bauer and Helene Götschel propose didactics and contents for trans-disciplinary pedagogical concepts that bring the natural sciences and Gender Studies into a constructive dialogue. Because of its many examples, this book will be helpful for all instructors of Gender Studies and offers important strategies and stimulation for approaching current challenges in the institutionalization of Gender Studies.

Security studies

International Nuclear Information System (INIS)

Venot, R.

2001-01-01

Full text: Security studies constitute one of the major tools for evaluating the provisions implemented at facilities to protect and control Nuclear Material against unauthorized removal. Operators use security studies to demonstrate that they are complying with objectives set by the Competent Authority to counter internal or external acts aimed at unauthorized removal of NM. The paper presents the context of security studies carried out in France. The philosophy of these studies is based on a postulated unauthorized removal of NM and the study of the behavior of the systems implemented to control and protect NM in a facility. The potential unauthorized removal of NM usually may take place in two stages. The first stage involves the sequence leading to handling of the NM. It occurs inside the physical barriers of a facility and may include action involving the documents corresponding to Material Control and Accounting systems. At this stage it is possible to limit the risk of unauthorized removal of NM by means of detection capabilities of the MC and A systems. The second stage is more specific to theft and involves removing the NM out of the physical barriers of a facility in which they are being held, notably by affecting the Physical Protection System. Operators have to study, from a quantity and time lapse point of view, the ability of the installed systems to detect unauthorized removal, as well as the possibility of tampering with the systems to mask unlawful operations. Operators have also to analyze the sequences during which NM are accessed, removed from their containment and further removed from the facility in which they are stored. At each stage in the process, the probability of detection and the time taken to carry out the above actions have to be estimated. Of course, these two types of studies complement each other. Security studies have begun, in France, for more than fifteen years. Up to now more than fifty security studies are available in the

The household contact study design for genetic epidemiological studies of infectious diseases

Directory of Open Access Journals (Sweden)

Catherine eStein

2013-04-01

Full Text Available Most genetic epidemiological study designs fall into one of two categories: family-based and population-based (case-control. However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis. Though we highlight its applicability for genetic epidemiological studies of infectious diseases, there are many facets of this design that are appealing for modern genetic studies, including the simultaneous enrollment of related and unrelated individuals, closely and distantly related individuals, collection of extensive epidemiologic and phenotypic data, and evaluation of effects of shared environment and gene by environment interaction. These study design characteristics are particularly appealing for current sequencing studies.

Security+ study guide study guide and practice exam

CERN Document Server

Dubrawsky, Ido; Dubrawsky

2007-01-01

Over 700,000 IT Professionals Have Prepared for Exams with Syngress Authored Study GuidesThe Security+ Study Guide & Practice Exam is a one-of-a-kind integration of text and and Web-based exam simulation and remediation. This system gives you 100% coverage of official CompTIA Security+ exam objectives plus test preparation software for the edge you need to achieve certification on your first try! This system is comprehensive, affordable, and effective!* Completely Guaranteed Coverage of All Exam ObjectivesAll five Security+ domains are covered in full: General Securi

Implementation of case studies in undergraduate didactic nursing courses: a qualitative study.

Science.gov (United States)

Dutra, Danette K

2013-07-04

The implementation of unfolding scenario-based case studies in the didactic classroom is associated with learner-centered education. The utilization of learner-centered pedagogies, such as case studies, removes the focus from the instructor and instead places it on the student. Learner-centered pedagogies are believed to improve students' levels of cognition. The purpose of this study was to examine how nurse educators are implementing the pedagogies of case studies in their undergraduate didactic courses. The goal was to examine, document, report, and, ultimately, implement the strategies. Purposeful sampling was utilized in this qualitative, multisite-designed study. For each of the four participants, three separate site visits were completed. Observations and post-observational interviews took place at each site visit. Transcribed data from interviews, observations, and course documents were imported into the computer program Nvivo8. Repetitive comparative analysis was utilized to complete the data coding process. The guiding research question of this study sought to investigate the implementation strategies of case studies in didactic nursing courses. The implementation of case studies by the participants reflected two primary patterns: Formal Implementation (FI) and Informal Implementation (II) of case studies. The FI of case studies was further divided into two subcategories: Formal Implementation of case studies used Inside the Classroom setting (FIIC) and Formal Implementation of cases studies used Outside of the Classroom (FIOC). Results of this investigation have led to an increased understanding of implementation strategies of unfolding scenario-based case studies in undergraduate nursing didactic courses. Data collected were rich in the description of specific methodologies for utilization of case studies and may serve as a resource for faculty in development of creative strategies to enhance the didactic classroom experience.

Single Policy Study

DEFF Research Database (Denmark)

Kronsell, Annica; Manners, Ian James

2015-01-01

Single policy studies are the most common form of European Union (EU) research. Single policy studies are widely used to understand the role of the EU in a wide variety of sectors, together with their development over time, and often offer public policy prescriptions. This chapter discusses...... the relevance of single policy studies in EU research and give examples of how such research can be designed and carried out. The chapter reviews three examples of single policy studies using different methods based on EU environmental policy, the EU biofuels directive, and the EU Common Security and Defence...... Policy (CSDP). The examples are illustrative of how single policy studies can be designed to use different approaches in the analysis: multiple streams approach to policy-making; a comparative hypothesis testing; and feminist institutional theory....

ARHCO studies

International Nuclear Information System (INIS)

Rogers, L.E.

1977-01-01

Ecological studies at the Hanford Reservation are designed to clarify ecosystem structure and function in and near the radioactive waste management areas. To date, emphasis has been placed on characterizing the abiotic and biotic components of these areas. During the current year, deer, raptors, coots, and mice have been under active study with respect to their potential for dissemination of radioactivity from pond or burial locations via feeding

Cost-of-illness studies for bipolar disorder: systematic review of international studies.

Science.gov (United States)

Jin, Huajie; McCrone, Paul

2015-04-01

Bipolar disorder (BD) may result in a greater burden than all forms of cancer, Alzheimer's disease and epilepsy. Cost-of-illness (COI) studies provide useful information on the economic burden that BD imposes on a society. Furthermore, COI studies are pivotal sources of evidence used in economic evaluations. This study aims to give a general overview of COI studies for BD and to discuss methodological issues that might potentially influence results. This study also aims to provide recommendations to improve practice in this area, based on the review. A search was performed to identify COI studies of BD. The following electronic databases were searched: MEDLINE, EMBASE, PsycInfo, Cochrane Database of Systematic Reviews, HMIC and openSIGLE. The primary outcome of this review was the annual cost per BD patient. A narrative assessment of key methodological issues was also included. Based on these findings, recommendations for good practice were drafted. Fifty-four studies were included in this review. Because of the widespread methodological heterogeneity among included studies, no attempt has been made to pool results of different studies. Potential areas for methodological improvement were identified. These were: description of the disease and population, the approach to deal with comorbidities, reporting the rationale and impact for choosing different cost perspectives, and ways in which uncertainty is addressed. This review showed that numerous COI studies have been conducted for BD since 1995. However, these studies employed varying methods, which limit the comparability of findings. The recommendations provided by this review can be used by those conducting COI studies and those critiquing them, to increase the credibility and reporting of study results.

Effects of Study and Self-reward Skills Counselling on Study ...

African Journals Online (AJOL)

reward skills counselling on students' study behaviour. It was also intended to ascertain the influence of gender on the study behaviour of participants in the experimental and control groups. Two null hypotheses were formulated.

Hawaii Solar Integration Study: Solar Modeling Developments and Study Results; Preprint

Energy Technology Data Exchange (ETDEWEB)

Orwig, K.; Corbus, D.; Piwko, R.; Schuerger, M.; Matsuura, M.; Roose, L.

2012-12-01

The Hawaii Solar Integration Study (HSIS) is a follow-up to the Oahu Wind Integration and Transmission Study completed in 2010. HSIS focuses on the impacts of higher penetrations of solar energy on the electrical grid and on other generation. HSIS goes beyond the island of Oahu and investigates Maui as well. The study examines reserve strategies, impacts on thermal unit commitment and dispatch, utilization of energy storage, renewable energy curtailment, and other aspects of grid reliability and operation. For the study, high-frequency (2-second) solar power profiles were generated using a new combined Numerical Weather Prediction model/ stochastic-kinematic cloud model approach, which represents the 'sharp-edge' effects of clouds passing over solar facilities. As part of the validation process, the solar data was evaluated using a variety of analysis techniques including wavelets, power spectral densities, ramp distributions, extreme values, and cross correlations. This paper provides an overview of the study objectives, results of the solar profile validation, and study results.

INEL design studies in support of the Westinghouse EPRI small plant study

International Nuclear Information System (INIS)

Burtt, J.D.; Kullberg, C.M.

1986-03-01

In support of the design effort of a Westinghouse EPRI small plant study, several analyses were performed at the Idaho National Engineering Laboratory. An analysis was performed to study fuel behavior under conditions of a limiting flow coastdown transient. Depressurization capabilities for the reactor coolant system were studied. The post-accident heat removal for the current containment design was studied. The results of all three studies are reported. 31 figs

Electric-powered passenger vehicle design study program. Task 1. Tradeoff studies

Energy Technology Data Exchange (ETDEWEB)

Rowlett, B.H.

1976-09-16

Using the baseline vehicle and power system design established previously to meet the performance goals of the program, three power system computer simulation programs were prepared for the basic vehicle tradeoff studies. These programs simulate the performance of the power system and vehicle over different types of driving conditions such as maximum power acceleration, deceleration, city driving cycles, and hill climbing, and permit accurate determination of the benefits of the unique hybrid power system, the total energy required for the suburban city driving cycle, and the extremes of the operating envelopes of the components so that component design options can be defined and studied. Component design tradeoff studies were conducted, including sensitivity studies to show the criticality of the various losses and unknowns in the analytical models. Also, preliminary vehicle layout studies were performed to determine the best locations of the power system and the batteries. Three basic design options are identified for further study. Economic studies were initiated using analytical models to establish the complete vehicle weight and cost breakdowns. Preliminary reliability and safety studies were completed, and maintainability and safety certification criteria established. The detailed analysis of the power system has verified the feasibility of the system and of the performance expectations. Also, the feasibility of energy recovery from regenerative braking has been confirmed. The sensitivity analysis of the power system shows that sufficient margin for unknown design variables is provided. The preliminary economic analysis indicates that the most difficult objective of the study will be the selection of the cost and weight relationships which are required to achieve the overall cost objectives.

Parents Studying Medicine – the dichotomy of studying with a family

Science.gov (United States)

Iden, Kirstin; Nürnberger, Frank; Sader, Robert; Dittrich, Winand

2012-01-01

Introduction: In this article the personal study and life situation of parents who are also medical students at the Medical School of the Goethe University Frankfurt am Main is discussed. There is a special focus on the topics “studying with children” and “family-friendly university”, which have been present in discussions about university development and in the daily life of academics, especially during the last decade. The workgroup “Individual Student Services” at the medical faculty at the Goethe University tries to meet the necessities of the individual study courses and to support the study success with a new counselling and student service concept. Methods: The experience of parents studying medicine was recorded in semi-structured interviews (Date: April 2010), which were held as part of the sponsored pilot project on part-time medical studies (“Pilot Project Part-time Medical Studies”). Additionally, study results from the Medical School of the Goethe University Frankfurt am Main were integrated as well as a literature analysis. Results: It was found that the teaching demands and support services, which have been suggested and needed for years now, have been partially implemented and are without sufficient support at the faculty level to date. Thus the current situation of medical students with children is still difficult and seems a big challenge for everyone involved. Solution: As part of the “Individual Student Services” a new pilot project on part-time medical studies was established in November 2009. Only the use of new, unconventional and innovative ideas allows universities to adequately support the changing and heterogeneous student population and support them to successfully completing their medical studies. PMID:22558026

Information society studies

CERN Document Server

Duff, Alistair S

2013-01-01

We are often told that we are ""living in an information society"" or that we are ""information workers."" But what exactly do these claims mean, and how might they be verified? In this important methodological study, Alistair S. Duff cuts through the rhetoric to get to the bottom of the ""information society thesis."" Wide-ranging in coverage, this study will be of interest to scholars in information science, communication and media studies and social theory. It is a key text for the newly-unified specialism of information society studies, and an indispensable guide to the future of this disc

The Development of Study Orientations and Study Success in Students of Pharmacy

Science.gov (United States)

Nieminen, Juha; Lindblom-Ylanne, Sari; Lonka, Kirsti

2004-01-01

In research literature, two study orientations have been identified: meaning orientation and reproducing orientation. Few studies have examined how study orientations and conceptions of knowledge (epistemologies) interrelate. Further, longitudinal studies of the development of orientations and of conceptions of knowledge in relation to academic…

Job stress, absenteeism and coronary heart disease European cooperative study (the JACE study): Design of a multicentre prospective study

NARCIS (Netherlands)

Houtman, I.; Kornitzer, M.; Smet, P. de; Koyuncu, R.; Backer, G. de; Pelfrene, E.; Romon, M.; Boulenguez, C.; Ferrario, M.; Origgi, G.; Sans, S.; Perez, I.; Wilhelmsen, L.; Rosengren, A.; Isacsson, S.-O.; Östergren, P.-O.

1999-01-01

Background: The motives, objectives and design of a multicentre prospective study on job stress, absenteeism and coronary heart disease in Europe (the JACE study) is presented in this paper. Some specific gaps in the reviewed literature are explicitly tapped into by the JACE study. Its objectives

Driving clinical study efficiency by using a productivity breakdown model: comparative evaluation of a global clinical study and a similar Japanese study.

Science.gov (United States)

Takahashi, K; Sengoku, S; Kimura, H

2011-02-01

A fundamental management imperative of pharmaceutical companies is to contain surging costs of developing and launching drugs globally. Clinical studies are a research and development (R&D) cost driver. The objective of this study was to develop a productivity breakdown model, or a key performance indicator (KPI) tree, for an entire clinical study and to use it to compare a global clinical study with a similar Japanese study. We, thereby, hope to identify means of improving study productivity. We developed the new clinical study productivity breakdown model, covering operational aspects and cost factors. Elements for improving clinical study productivity were assessed from a management viewpoint by comparing empirical tracking data from a global clinical study with a Japanese study with similar protocols. The following unique and material differences, beyond simple international difference in cost of living, that could affect the efficiency of future clinical trials were identified: (i) more frequent site visits in the Japanese study, (ii) head counts at the Japanese study sites more than double those of the global study and (iii) a shorter enrollment time window of about a third that of the global study at the Japanese study sites. We identified major differences in the performance of the two studies. These findings demonstrate the potential of the KPI tree for improving clinical study productivity. Trade-offs, such as those between reduction in head count at study sites and expansion of the enrollment time window, must be considered carefully. © 2010 Blackwell Publishing Ltd.

The Implementation of Lesson Study in English Language Learning: A Case Study

Directory of Open Access Journals (Sweden)

Wakhid Nashruddin

2016-12-01

Full Text Available Lesson Study as a growing interest in the education world has attracted educators, experts, and professionals in the area to make use of it in improving the lessons—it also happens in Indonesia. Originally applied in the teaching of mathematics in Japan, now it turns to be used in other fields, and English is one of them. This paper highlights the guideline on Lesson Study and pictures its application in a private senior high school in Malang, East Java, Indonesia. The adaptation of Lesson Study is interesting since Japan and Indonesia have different cultural background. How Lesson Study is usually implemented in Japan and the US and how it is applied in Indonesia will be seen here. As this is a case study, it will only focus on a school and the result should not be used to generalize Lesson Study applications in Indonesia. Interview and observation were instruments used in this study. The interview was used to gain information on how Lesson Study was normally conducted and observation (and the researchers’ involvements was used to see the real implementation of Lesson Study. What happened during the implementation of Lesson Study and during the teaching and learning process become a great attention here.

Longitudinal Andhra Pradesh Eye Disease Study: rationale, study design and research methodology.

Science.gov (United States)

Khanna, Rohit C; Murthy, Gudlavalleti Vs; Marmamula, Srinivas; Mettla, Asha Latha; Giridhar, Pyda; Banerjee, Seema; Shekhar, Konegari; Chakrabarti, Subhabrata; Gilbert, Clare; Rao, Gullapalli N

2016-03-01

The rationale, objectives, study design and procedures for the longitudinal Andhra Pradesh Eye Disease Study are described. A longitudinal cohort study was carried out. Participants include surviving cohort from the rural component of Andhra Pradesh Eye Disease Study. During 1996-2000, Andhra Pradesh Eye Disease Survey was conducted in three rural (n = 7771) and one urban (n = 2522) areas (now called Andhra Pradesh Eye Disease Study 1). In 2009-2010, a feasibility exercise (Andhra Pradesh Eye Disease Study 2) for a longitudinal study (Andhra Pradesh Eye Disease Study 3) was undertaken in the rural clusters only, as urban clusters no longer existed. In Andhra Pradesh Eye Disease Study 3, a detailed interview will be carried out to collect data on sociodemographic factors, ocular and systemic history, risk factors, visual function, knowledge of eye diseases and barriers to accessing services. All participants will also undergo a comprehensive eye examination including photography of lens, optic disc and retina, Optic Coherence Tomography of the posterior segment, anthropometry, blood pressure and frailty measures. Measures include estimates of the incidence of visual impairment and age-related eye disease (lens opacities, glaucoma and age-related macular degeneration) and the progression of eye disease (lens opacities and myopia) and associated risk factors. Of the 7771 respondents examined in rural areas in Andhra Pradesh Eye Disease Study 1, 5447 (70.1%) participants were traced in Andhra Pradesh Eye Disease Study 2. These participants will be re-examined. Andhra Pradesh Eye Disease Study 3 will provide data on the incidence and progression of visual impairment and major eye diseases and their associated risk factors in India. The study will provide further evidence to aid planning eye care services. © 2015 Royal Australian and New Zealand College of Ophthalmologists.

A proposal to study the esophageal transit by biomagnetic and scintigraphic study

International Nuclear Information System (INIS)

Daghastanli, N.A.; Braga, F.J.H.N.; Baffa, O.

1996-01-01

The initial results for a new apparatus to study the esophageal transit time is studied in asymptomatic persons for a yogurt bolus (10 ml). The bolus is uniformly labeled with 5 g of ferrite powder (biomagnetic study, B) or 350 MBq of 99m Tc (scintigraphic study, C). For the B study the detection is made by means two pair of coils in opposite phase excited by a 10 k Hz sinusoidal voltage. The signal response is obtained when the bolus traverses the coils placed on the regions-of-interest (ROIs) of the esophagus (furcula, F and xiphoid process, X) and produces a signal voltage that is measured by a lock-in amplifier Stanford SR530. For C studies an Orbiter Siemens scintillation camera is used linked to a computer. The data analysis shows a (4.1±0.7)s in B studies and (3.7±0.9)s in C studies (R=0.6, P<0.07)

Behavior Modification of Studying Through Study Skills Advice and Self-Control Procedures

Science.gov (United States)

Richards, C. Steven

1975-01-01

Investigates the efficacy of two behavioral self-control procedures as additions to the typical treatment for college students' study behavior--study skills advice. Predicted self-monitoring would be an effective treatment addition to study skills advice and study skills advice would be superior to the control groups. Results supported…

Enacting Disability: How Can Science and Technology Studies Inform Disability Studies?

Science.gov (United States)

Galis, Vasilis

2011-01-01

This paper aims to discuss how science and technology studies (STS) can inform disability studies and challenge dominant approaches, such as the medical and the social models, in the ordering and representation of disability. Disability studies and STS have followed somewhat parallel paths in the history of ideas. From a positivist approach to…

International user studies

DEFF Research Database (Denmark)

Nielsen, Lene; Madsen, Sabine; Jensen, Iben

In this report, we present the results of a research project about international user studies. The project has been carried out by researchers from the Center for Persona Research and –Application, The IT University in Copenhagen and the Department of Learning and Philosophy, Aalborg University...... in Sydhavnen, and it is funded by InfinIT. Based on a qualitative interview study with 15 user researchers from 11 different companies, we have investigated how companies collect and present data about users on international markets. Key findings are: Companies do not collect data about end users in all...... the countries/regions they operate in. Instead, they focus on a few strategic markets. International user studies tend to be large-scale studies that involve the effort of many both internal and external/local human resources. The studies typically cover 2-4 countries/regions and many end users in each country...

World Studies. Japan, India, China: Which Direction? Social Studies: 6478.20.

Science.gov (United States)

Abrams, Grace C.; Schmidt, Fran

This Quinmester world studies elective course for grades 7, 8, and 9, focuses on the comparative study of three far eastern nations: China, India, and Japan. The study examines the successes and failures of each nation in dealing with the common problems of over-population, industrialization, and literacy education, leading to speculation as to…

Italian Studies in Southern Africa/Studi d'Italianistica nell'Africa ...

African Journals Online (AJOL)

Italian Studies in Southern Africa/Studi d'Italianistica nell'Africa Australe - Vol 9, No 1 (1996) ... Politics and power in Giovanni Comisso's Giorni Di Guerra and Pier Vittorio Tondelli's Pao Pao ... Anna Meda, Gerhard van der Linde, 80-81 ...

Effects of curriculum organisation on study progress in engineering studies

NARCIS (Netherlands)

Hulst, M. van der; Jansen, E.

2002-01-01

Procrastination and time investment are important issues in the study of student performance and progress. Previous research on these issues has mainly concentrated upon individual differences between students in personality and time management skills. However, study progress depends not only on

Effects of curriculum organisation on study progress in engineering studies

NARCIS (Netherlands)

van der Hulst, M.; Jansen, E.P.W.A.

Procrastination and time investment are important issues in the study of student performance and progress. Previous research on these issues has mainly concentrated upon individual differences between students in personality and time management skills. However, study progress depends not only on

Accelerator research studies

International Nuclear Information System (INIS)

1992-01-01

The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy under grant number DE-FG05-91ER40642, is currently in the first year of a three-year funding cycle. The program consists of the following three tasks: TASK A, Study of Transport and Longitudinal Compression of Intense, High-Brightness Beams, TASK B, Study of Collective Ion Acceleration by Intense Electron Beams and Pseudospark Produced High Brightness Electron Beams; TASK C, Study of a Gyroklystron High-power Microwave Source for Linear Colliders. In this report we document the progress that has been made during the past year for each of the three tasks

Study Skills Analysis: A Pilot Study Linking a Success and Psychology Course

Science.gov (United States)

Urciuoli, Jannette Alejandra; Bluestone, Cheryl

2013-01-01

This study explored a concept that learning study skills in the context of the content area under study may transfer across courses, multiplying the benefits towards academic success. Methods that have been reported to influence academic growth at the community college level include success courses and applied study skills. In this pilot project…

Project studies

DEFF Research Database (Denmark)

Geraldi, Joana; Söderlund, Jonas

2018-01-01

Project organising is a growing field of scholarly inquiry and management practice. In recent years, two important developments have influenced this field: (1) the study and practice of projects have extended their level of analysis from mainly focussing on individual projects to focussing on micro......, and of the explanations of project practices they could offer. To discuss avenues for future research on projects and project practice, this paper suggests the notion of project studies to better grasp the status of our field. We combine these two sets of ideas to analyse the status and future options for advancing...... project research: (1) levels of analysis; and (2) type of research. Analysing recent developments within project studies, we observe the emergence of what we refer to as type 3 research, which reconciles the need for theoretical development and engagement with practice. Type 3 research suggests pragmatic...

Measuring taste impairment in epidemiologic studies: the Beaver Dam Offspring Study.

Science.gov (United States)

Cruickshanks, K J; Schubert, C R; Snyder, D J; Bartoshuk, L M; Huang, G H; Klein, B E K; Klein, R; Nieto, F J; Pankow, J S; Tweed, T S; Krantz, E M; Moy, G S

2009-07-01

Taste or gustatory function may play an important role in determining diet and nutritional status and therefore indirectly impact health. Yet there have been few attempts to study the spectrum of taste function and dysfunction in human populations. Epidemiologic studies are needed to understand the impact of taste function and dysfunction on public health, to identify modifiable risk factors, and to develop and test strategies to prevent clinically significant dysfunction. However, measuring taste function in epidemiologic studies is challenging and requires repeatable, efficient methods that can measure change over time. Insights gained from translating laboratory-based methods to a population-based study, the Beaver Dam Offspring Study (BOSS) will be shared. In this study, a generalized labeled magnitude scale (gLMS) method was used to measure taste intensity of filter paper disks saturated with salt, sucrose, citric acid, quinine, or 6-n-propylthiouracil, and a gLMS measure of taste preferences was administered. In addition, a portable, inexpensive camera system to capture digital images of fungiform papillae and a masked grading system to measure the density of fungiform papillae were developed. Adult children of participants in the population-based Epidemiology of Hearing Loss Study in Beaver Dam, Wisconsin, are eligible for this ongoing study. The parents were residents of Beaver Dam and 43-84 years of age in 1987-1988; offspring ranged in age from 21-84 years in 2005-2008. Methods will be described in detail and preliminary results about the distributions of taste function in the BOSS cohort will be presented.

Building theories from case study research: the progressive case study

NARCIS (Netherlands)

Steenhuis, H.J.; de Bruijn, E.J.

2006-01-01

Meredith (1998) argues for more case and field research studies in the field of operations management. Based on a literature review, we discuss several existing approaches to case studies and their characteristics. These approaches include; the Grounded Theory approach which proposes no prior

"Oh Events" for the Professor: Studies and Stories of Religious Studies Abroad

Science.gov (United States)

Barbour, John D.

2015-01-01

This response explains three ways in which the preceding essays are a significant contribution to the study of study abroad, explores three additional issues, and makes three suggestions for future work on religious studies and study abroad. This response is published alongside of six other essays, comprising a special section of the journal (see…

A study of critical paths for feasibility studies of mining projects

International Nuclear Information System (INIS)

Sayadi, R.

2002-01-01

This work develops a model for design and realisation of profitability's and feasibility studies of a mining project. The model provides the structure of various necessary procedures to establish the feasibility studies and presents a logical system of task sequencing and information circulating between tasks. The specifications of mining projects, particularly their duration, complexity and high costs, necessitate design and realisation of feasibility study bases on the sufficient understanding of task behaviour and the critical path method view. For this purpose, critical paths with the highest frequency of occurrence were studied through several simulations. In addition, the critical tasks and sub tasks with the most probability were identified. The model introduced in this paper can serve as a perfect tool in feasibility study of a mining project. It can also be used as a basis of future development of mining software

Study management – process experiences form The Elderly Study

DEFF Research Database (Denmark)

Bilberg, Randi Marie; Andersen, Kjeld; Bogenschutz, Michael P

and prevention of sites that drift away. Implications The Elderly Study is multi-nationally, including three universities and research center in USA, Germany and Denmark together with a lot of outpatient treatment facilities. The study aims at including 1,000 patients aged 60 and older to examine two therapies......Description An essential, but often not described, part of multisite research projects is the process of managing the overall project per se. The Elderly have implemented strategies and tools used across sites in order to ensure intervention fidelity, uniformness in collection of data...... targeting seniors with alcohol problems. A lot of information, documentations, materials and agreements within and between sites are common phenomenons in the study. Therefore we are using Internet solutions as much as possible. Document management: To avoid having to many different versions of the same...

Conduct of a personal radiofrequency electromagnetic field measurement study: proposed study protocol.

Science.gov (United States)

Röösli, Martin; Frei, Patrizia; Bolte, John; Neubauer, Georg; Cardis, Elisabeth; Feychting, Maria; Gajsek, Peter; Heinrich, Sabine; Joseph, Wout; Mann, Simon; Martens, Luc; Mohler, Evelyn; Parslow, Roger C; Poulsen, Aslak Harbo; Radon, Katja; Schüz, Joachim; Thuroczy, György; Viel, Jean-François; Vrijheid, Martine

2010-05-20

The development of new wireless communication technologies that emit radio frequency electromagnetic fields (RF-EMF) is ongoing, but little is known about the RF-EMF exposure distribution in the general population. Previous attempts to measure personal exposure to RF-EMF have used different measurement protocols and analysis methods making comparisons between exposure situations across different study populations very difficult. As a result, observed differences in exposure levels between study populations may not reflect real exposure differences but may be in part, or wholly due to methodological differences. The aim of this paper is to develop a study protocol for future personal RF-EMF exposure studies based on experience drawn from previous research. Using the current knowledge base, we propose procedures for the measurement of personal exposure to RF-EMF, data collection, data management and analysis, and methods for the selection and instruction of study participants. We have identified two basic types of personal RF-EMF measurement studies: population surveys and microenvironmental measurements. In the case of a population survey, the unit of observation is the individual and a randomly selected representative sample of the population is needed to obtain reliable results. For microenvironmental measurements, study participants are selected in order to represent typical behaviours in different microenvironments. These two study types require different methods and procedures. Applying our proposed common core procedures in future personal measurement studies will allow direct comparisons of personal RF-EMF exposures in different populations and study areas.

Qualitative "trial-sibling" studies and "unrelated" qualitative studies contributed to complex intervention reviews.

Science.gov (United States)

Noyes, Jane; Hendry, Margaret; Lewin, Simon; Glenton, Claire; Chandler, Jackie; Rashidian, Arash

2016-06-01

To compare the contribution of "trial-sibling" and "unrelated" qualitative studies in complex intervention reviews. Researchers are using qualitative "trial-sibling" studies undertaken alongside trials to provide explanations to understand complex interventions. In the absence of qualitative "trial-sibling" studies, it is not known if qualitative studies "unrelated" to trials are helpful. Trials, "trial-sibling," and "unrelated" qualitative studies looking at three health system interventions were identified. We looked for similarities and differences between the two types of qualitative studies, such as participants, intervention delivery, context, study quality and reporting, and contribution to understanding trial results. Reporting was generally poor in both qualitative study types. We detected no substantial differences in participant characteristics. Interventions in qualitative "trial-sibling" studies were delivered using standardized protocols, whereas interventions in "unrelated" qualitative studies were delivered in routine care. Qualitative "trial-sibling" studies alone provided insufficient data to develop meaningful transferrable explanations beyond the trial context, and their limited focus on immediate implementation did not address all phenomena of interest. Together, "trial-sibling" and "unrelated" qualitative studies provided larger, richer data sets across contexts to better understand the phenomena of interest. Findings support inclusion of "trial-sibling" and "unrelated" qualitative studies to explore complexity in complex intervention reviews. Copyright © 2016 Elsevier Inc. All rights reserved.

Applied Research Study

Science.gov (United States)

Leach, Ronald J.

1997-01-01

The purpose of this project was to study the feasibility of reusing major components of a software system that had been used to control the operations of a spacecraft launched in the 1980s. The study was done in the context of a ground data processing system that was to be rehosted from a large mainframe to an inexpensive workstation. The study concluded that a systematic approach using inexpensive tools could aid in the reengineering process by identifying a set of certified reusable components. The study also developed procedures for determining duplicate versions of software, which were created because of inadequate naming conventions. Such procedures reduced reengineering costs by approximately 19.4 percent.

Mysore study: A study of suicide notes.

Science.gov (United States)

Namratha, P; Kishor, M; Sathyanarayana Rao, T S; Raman, Rajesh

2015-01-01

Suicide is one of the leading causes of preventable deaths. Recent data suggest South India as one of the regions with highest suicide rates in the world. In 2013, 134,799 people committed suicide in India according to the statistics released by the National Crime Records Bureau. Suicide note is one of the most important sources to understand suicide, which may be beneficial in suicide prevention. Studies on suicidal notes from this part of the world are sparse. The aim was to study the themes in suicide notes that might be useful in prevention strategies. A descriptive study of all suicide notes of those individuals who committed suicide between 2010 and 2013 available with Police Department, Mysore district was obtained and analyzed. A total of 22 suicide note were available. A majority of suicide note was in age group of 16-40 years (86%) and most were men (59%). All suicide notes were handwritten, the majority (70%) in regional language Kannada. Length of notes varied from just few words to few pages. Contents of suicide notes included apology/shame/guilt (80%), love for those left behind (55%) and instruction regarding practical affairs (23%). Most have blamed none for the act (50%). 23% mentioned that they are committing suicide to prove their innocence. 32% mentioned a last wish. The majority of suicidal note contained "guilt" which is a strong indicator of possible depression in deceased. Creating awareness about suicide among public and ensuring access to professionals trained in suicide prevention is need of the hour in this part of the world.

Doing Cultural Studies

DEFF Research Database (Denmark)

du Gay, Paul; Hall, Stuart; Janes, Linda

What does the Walkman have to do with the 21st century? The long-awaited second edition of this classic textbook takes students on a journey between past and present, giving them the skills do to cultural analysis along the way. Through the notion of the 'circuit of culture', this book teaches st......' for cultural studies. It is an essential classic, reworked for today's students in cultural studies, media studies and sociology....

Descriptive studies of Purepecha: Introductory study

Directory of Open Access Journals (Sweden)

Violeta Vázquez Rojas Maldonado

2013-12-01

Full Text Available Seven papers in this volume are the result of a collective project of linguistic description. This introduction offers a general background for such enterprise. It provides information about some sociolinguistic and grammatical aspects of the Purepecha language, a list of some recent studies on the language, it describes the orthographic conventions employed. We also provide details about the elicitation methodology and the demographic information of the language consultants.

Study Drugs

OpenAIRE

Lam, Stephanie Phuong; Roosta, Natalie; Nielsen, Mikkel Fuhr; Meyer, Maria Holmgaard; Friis, Katrine Birk

2016-01-01

In recent years, students around the world, started to use preparations as Ritalin and Modafinil,also known as study drugs, to improve their cognitive abilities1. It is a common use among thestudents in United States of America, but it is a new tendency in Denmark. Our main focus is tolocate whether study drugs needs to be legalized in Denmark or not. To investigate this ourstarting point is to understand central ethical arguments in the debate. We have chosen twoarguments from Nick Bostrom a...

Conduct of a personal radiofrequency electromagnetic field measurement study: proposed study protocol

Directory of Open Access Journals (Sweden)

Radon Katja

2010-05-01

Full Text Available Abstract Background The development of new wireless communication technologies that emit radio frequency electromagnetic fields (RF-EMF is ongoing, but little is known about the RF-EMF exposure distribution in the general population. Previous attempts to measure personal exposure to RF-EMF have used different measurement protocols and analysis methods making comparisons between exposure situations across different study populations very difficult. As a result, observed differences in exposure levels between study populations may not reflect real exposure differences but may be in part, or wholly due to methodological differences. Methods The aim of this paper is to develop a study protocol for future personal RF-EMF exposure studies based on experience drawn from previous research. Using the current knowledge base, we propose procedures for the measurement of personal exposure to RF-EMF, data collection, data management and analysis, and methods for the selection and instruction of study participants. Results We have identified two basic types of personal RF-EMF measurement studies: population surveys and microenvironmental measurements. In the case of a population survey, the unit of observation is the individual and a randomly selected representative sample of the population is needed to obtain reliable results. For microenvironmental measurements, study participants are selected in order to represent typical behaviours in different microenvironments. These two study types require different methods and procedures. Conclusion Applying our proposed common core procedures in future personal measurement studies will allow direct comparisons of personal RF-EMF exposures in different populations and study areas.

The Field Trip Book: Study Travel Experiences in Social Studies

Science.gov (United States)

Morris, Ronald V.

2010-01-01

Looking for social studies adventures to help students find connections to democratic citizenship? Look no further! This book provides just the answer teachers need for engaging students in field trips as researching learners with emphasis on interdisciplinary social studies plus skills in collecting and reporting data gathered from field…

Social Studies Student Teachers' Levels of Understanding Sociology Concepts within Social Studies Curriculum

Science.gov (United States)

Karatekin, Kadir

2013-01-01

This study aims at investigating social studies student teachers' levels of understanding sociology concepts within social studies curriculum. Study group of the research consists of 266 teacher candidates attending the Department of Social Studies, Faculty of Education, Kastamonu University during 2012 to 2013 education year. A semi-structured…

IRD dropout study

Science.gov (United States)

Yalowitz, Jeffrey S.; Schroer, Michael A.; Dickson, John E., Jr.

1992-01-01

This final report describes work performed by SRS Technologies for the NASA Marshall Space Flight Center under Contract NAS8-39077, entitled 'Integrated Receiver-Decoder Dropout Study'. The purpose of the study was to determine causes of signal fading effects on ultra-high-frequency (UHF) range safety transmissions to the Space Shuttle during flyout. Of particular interest were deep fades observed at the External Tank (ET) Integrated Receiver-Decoder (IRD) during the flyout interval between solid rocket booster separation and ET separation. Analytical and simulation methods were employed in this study to assess observations captured in flight telemetry data records. Conclusions based on the study are presented in this report, and recommendations are given for future experimental validation of the results.

Physics studies in Europe; a comparative study

NARCIS (Netherlands)

Steenstrup, S; dalle Rose, LFD; Jones, WG; Tugulea, L; van Steenwijk, FJ

What are the differences and similarities between physics studies at different universities across Europe (here the definition of Europe is broad)? How much does a student have to work to obtain a degree in physics? Questions like those prompted EUPEN (European Physics Education Network) to make a

76 FR 40379 - New Proposed Collection; Comment Request; Study Logistic Formative Research Methodology Studies...

Science.gov (United States)

2011-07-08

...; Comment Request; Study Logistic Formative Research Methodology Studies for the National Children's Study... Collection Title: Study Logistics Formative Research Methodology Studies for the National Children's Study... national longitudinal study of environmental influences (including physical, chemical, biological, and...

A Case Study Application Of Time Study Model In Paint ...

African Journals Online (AJOL)

This paper presents a case study in the development and application of a time study model in a paint manufacturing company. The organization specializes in the production of different grades of paint and paint containers. The paint production activities include; weighing of raw materials, drying of raw materials, dissolving ...

Case study: An ethics case study of HIV prevention research on Facebook: the Just/Us study.

Science.gov (United States)

Bull, Sheana S; Breslin, Lindsey T; Wright, Erin E; Black, Sandra R; Levine, Deborah; Santelli, John S

2011-01-01

To consider issues related to research with youth on social networking sites online. Description of the data collection process from 1,588 participants in a randomized controlled trial testing the efficacy of HIV prevention education delivered on Facebook. Using respondent-driven sampling, staff-recruited participants are encouraged to recruit up to three friends to enroll in the study. Researchers should (a) consider whether an online social networking site is an appropriate place to implement a research study; (b) offer opportunities to review informed consent documents at multiple times and in multiple locations throughout the study; and (c) collect data outside the social networking site and store it behind secure firewalls to ensure it will not be accessible to any person on the social networking site. Online social networks are growing in popularity. Conducting research on social media sites requires deliberate attention to consent, confidentiality, and security.

Towards Marxian Internet Studies

Directory of Open Access Journals (Sweden)

Christian Fuchs

2012-05-01

Full Text Available This article gives an overview of example approaches of Critical Internet Studies and points out key concepts of this field. Critical Cyberculture Studies and Critical Political Economy/Critical Theory of the Internet are identified as two approaches in Critical Internet Studies. The paper also discusses the role of 11 Marxian concepts for Critical Internet Studies. Marxian concepts that have been reflected in Critical Internet Studies include: dialectics, capitalism, commodification, surplus value/exploitation/alienation/class, globalization, ideology, class struggle, commons, public sphere, communism, and aesthetics. The paper points out the importance of explicitly acknowledging the importance of Karl Marx’s thinking in Critical Internet Studies. Marx’s concepts are today frequently used implicitly, without acknowledging and engaging with their roots. A critique of the approach of “Critical” Cyberculture Studies is advanced. This approach is compared to the approaches of Critical Theory and Critical Political Economy of the Internet. The difference between these two approaches reflects the debate about class exploitation and non-class domination between Cultural Studies and Critical Political Economy in Media and Communication Studies.

ANALISIS KESIAPAN PROGRAM STUDI DALAM PRODUCTION BASED EDUCATION: STUDI PADA PROGRAM STUDI D3 AKUNTANSI POLINES

Directory of Open Access Journals (Sweden)

Muhammad Noor Ardiansah

2015-03-01

Full Text Available There has been no clear studies to identify, verify and analyze readiness program resources in order to study the implementation of PBE resulted in initial position (existing point is not clear that the priority programs and activities that are carried out per year tend to be responsive and not directed priorities. These conditions resulted in analysis of resource readiness courses in the management of production-based learning pattern PBE draw conducted This study aims to identify and verify and analyze readiness resources management courses in the pattern of production based learning, particularly in the Accounting Studies Program. This research is expected to be used to increase the effectiveness of learning and vocational education to improve the quality and relevance of polytechnic graduates. Total score was 33 the existence of resources from the scale of 12-60. The average score is 2.75. The average score was shown the position of Prodi's resources have been used, but its role is unclear (repeatable tend to have clearly defined functions, communicated and documented (defined. Resources have been managed, monitored and evaluated well (managed are: curriculum resources, networking courses, lab facilities, ISO-based management. Resources have been used but not optimal role: resources module practice, the formulation of an internship, practice material / TA, the performance of IC-based lecturer

ANALISIS KESIAPAN PROGRAM STUDI DALAM PRODUCTION BASED EDUCATION: STUDI PADA PROGRAM STUDI D3 AKUNTANSI POLINES

Directory of Open Access Journals (Sweden)

Muhammad Noor Ardiansah

2014-06-01

Full Text Available There has been no clear studies to identify, verify and analyze readiness program resources in order to study the implementation of PBE resulted in initial position (existing point is not clear that the priority programs and activities that are carried out per year tend to be responsive and not directed priorities. These conditions resulted in analysis of resource readiness courses in the management of production-based learning pattern PBE draw conducted This study aims to identify and verify and analyze readiness resources management courses in the pattern of production based learning, particularly in the Accounting Studies Program. This research is expected to be used to increase the effectiveness of learning and vocational education to improve the quality and relevance of polytechnic graduates. Total score was 33 the existence of resources from the scale of 12-60. The average score is 2.75. The average score was shown the position of Prodi's resources have been used, but its role is unclear (repeatable tend to have clearly defined functions, communicated and documented (defined. Resources have been managed, monitored and evaluated well (managed are: curriculum resources, networking courses, lab facilities, ISO-based management. Resources have been used but not optimal role: resources module practice, the formulation of an internship, practice material / TA, the performance of IC-based lecturer

Research on the phenomenon of graphitization. Crystallographic study - Study of bromine sorption

International Nuclear Information System (INIS)

Maire, Jacques

1967-01-01

This research thesis reports the study of the mechanism of graphitization of carbon by using X-ray diffraction analysis and the physical and chemical study of lamellar reactions between carbon and bromine. The author first presents generalities and results of preliminary studies (meaning of graphitization, presentation of the various carbon groups and classes), and then reports the study of the graphitization of compact carbons (soft carbons). More precisely, he reports the crystallographic study of partially graphitized carbons: methods and principles, experimental results and their analysis, discussion of the graphitization mechanism. In the next part, the author reports the study of bromine sorption on carbons: experimental method, isotherms of a natural graphite and of a graphitized carbon, structure of carbon-bromine complexes, isotherms of graphitizable carbons and of all other carbons, distribution of bromine layers in partially graphitized carbons, bromine sorption and Fermi level

Advanced nuclear systems. Review study; Fortgeschrittene Nuklearsysteme. Review Study

Energy Technology Data Exchange (ETDEWEB)

Liebert, Wolfgang; Glaser, Alexander; Pistner, Christoph [Interdisziplinaere Arbeitsgruppe Naturwissenschaft, Technik und Sicherheit (IANUS), Darmstadt University of Technology, Hochschulstrasse 10, D-64289 Darmstadt (Germany); Baehr, Roland; Hahn, Lothar [Institute for applied ecology (Oeko-Institut), Elisabethenstrasse 55-57, D-64283 Darmstadt (Germany)

1999-04-01

The task of this review study is to from provide an overview of the developments in the field of the various advanced nuclear systems, and to create the basis for more comprehensive studies of technology assessment. In an overview the concepts for advanced nuclear systems pursued worldwide are subdivided into eight subgroups. A coarse examination raster (set pattern) is developed to enable a detailed examination of the selected systems. In addition to a focus on enhanced safety features, further aspects are also taken into consideration, like the lowering of the proliferation risk, the enhancement of the economic competitiveness of the facilities and new usage possibilities (for instance concerning the relaxation of the waste disposal problem or the usage of alternative fuels to uranium). The question about the expected time span for realization and the discussion about the obstacles on the way to a commercially usable reactor also play a substantial role as well as disposal requirements as far as they can be presently recognized. In the central chapter of this study, the documentation of the representatively selected concepts is evaluated as well as existing technology assessment studies and expert opinions. In a few cases where this appears to be necessary, according technical literature, further policy advisory reports, expert statements as well as other relevant sources are taken into account. Contradictions, different assessments and dissents in the literature as well as a few unsettled questions are thus indicated. The potential of advanced nuclear systems with respect to economical and societal as well as environmental objectives cannot exclusively be measured by the corresponding intrinsic or in comparison remarkable technical improvements. The acceptability of novel or improved systems in nuclear technology will have to be judged by their convincing solutions for the crucial questions of safety, nuclear waste and risk of proliferation of nuclear weapons

Current Research Studies

Science.gov (United States)

... Success Home > Explore Research > Current Research Studies Current Research Studies Email Print + Share The Crohn’s & Colitis Foundation ... conducted online. Learn more about IBD Partners. Clinical Research Alliance The Clinical Research Alliance is a network ...

INTEC High-Level Waste Studies Universal Solvent Extraction Feasibility Study

International Nuclear Information System (INIS)

Banaee, J.; Barnes, C.M.; Battisti, T.; Herrmann, S.; Losinski, S.J.; McBride, S.

2000-01-01

This report summarizes a feasibility study that has been conducted on the Universal Solvent Extraction (UNEX) Process for treatment and disposal of 4.3 million liters of INEEL sodium-bearing waste located at the Idaho Nuclear Technology and Engineering Center. This feasibility study covers two scenarios of treatment. The first, the UNEX Process, partitions the Cs/Sr from the SBW and creates remote-handled LLW and contact-handled TRU waste forms. Phase one of this study, covered in the 30% review documents, dealt with defining the processes and defining the major unit operations. The second phase of the project, contained in the 60% review, expanded on the application of the UNEX processes and included facility requirements and definitions. Two facility options were investigated for the UNEX process, resulting in a 2 x 2 matrix of process/facility scenarios as follows: Option A, UNEX at Greenfield Facility, Option B, Modified UNEX at Greenfield Facility, Option C, UNEX at NWCF, th is document, covers life-cycle costs for all options presented along with results and conclusions determined from the study

Pacific Studies: Quo Vadis?

Directory of Open Access Journals (Sweden)

Anne Holden Rønning

2014-02-01

Full Text Available Looking back to the past this paper discusses why Pacific studies and in particular Australasian studies became an area of interest in tertiary education in Europe. What subject areas initiated these studies, and how do past legacies shape the present? With cutbacks in higher education over the past two decades the future of interdisciplinary studies and the humanities looks bleak. At the same time due to global business and increased political communication across borders there is a vibrant interest in and need for such studies among businesses and students. For most Europeans the literature of settler countries, with their European legacy, makes access to ways of thought and culture easier than studies of countries with other mythological backgrounds. In today’s multicultural environment such studies can provide knowledge for an understanding of other cultures and increase tolerance of the ‘other’. Area studies have relevance to our situation in Europe with increased migrancy, not least as a result of Schengen and EU regulations.

Neutron beam studies

International Nuclear Information System (INIS)

Willis, B.T.M.; Apps, M.E.

1979-01-01

The report is in sections, entitled: metallurgy; reactor fuels; defect solid state and interatomic forces; surface studies; colloid, polymer and biological studies; glasses; energy-related materials; solid state physics and crystallography; instrumentation and experimental technique. (U.K.)

Case Study Research Methodology

Directory of Open Access Journals (Sweden)

Mark Widdowson

2011-01-01

Full Text Available Commenting on the lack of case studies published in modern psychotherapy publications, the author reviews the strengths of case study methodology and responds to common criticisms, before providing a summary of types of case studies including clinical, experimental and naturalistic. Suggestions are included for developing systematic case studies and brief descriptions are given of a range of research resources relating to outcome and process measures. Examples of a pragmatic case study design and a hermeneutic single-case efficacy design are given and the paper concludes with some ethical considerations and an exhortation to the TA community to engage more widely in case study research.

Study protocol: The Intensive Care Outcome Network ('ICON' study

Directory of Open Access Journals (Sweden)

Barber Vicki S

2008-06-01

Full Text Available Abstract Background Extended follow-up of survivors of ICU treatment has shown many patients suffer long-term physical and psychological consequences that affect their health-related quality of life. The current lack of rigorous longitudinal studies means that the true prevalence of these physical and psychological problems remains undetermined. Methods/Design The ICON (Intensive Care Outcome Network study is a multi-centre, longitudinal study of survivors of critical illness. Patients will be recruited prior to hospital discharge from 20–30 ICUs in the UK and will be assessed at 3, 6, and 12 months following ICU discharge for health-related quality of life as measured by the Short Form-36 (SF-36 and the EuroQoL (EQ-5D; anxiety and depression as measured by the Hospital Anxiety and Depression Scale (HADS; and post traumatic stress disorder (PTSD symptoms as measured by the PTSD Civilian Checklist (PCL-C. Postal questionnaires will be used. Discussion The ICON study will create a valuable UK database detailing the prevalence of physical and psychological morbidity experienced by patients as they recover from critical illness. Knowledge of the prevalence of physical and psychological morbidity in ICU survivors is important because research to generate models of causality, prognosis and treatment effects is dependent on accurate determination of prevalence. The results will also inform economic modelling of the long-term burden of critical illness. Trial Registration ISRCTN69112866

Accelerator research studies

International Nuclear Information System (INIS)

1990-01-01

This progress report for the Accelerator Research Studies program at the University of Maryland covers the second year (June 1, 1989 to May 31, 1990) of the current three-year contract period from June 1, 1988 to May 31, 1991, funded by the Department of Energy under Contract No. AC05-85ER40216. The research program is divided into three separate tasks, as follows: the study of Transport and Longitudinal Compression of Intense, High-Brightness Beams; the study of Collective Ion Acceleration by Intense Electron Beams and Pulse-Powered Plasma Focus; the study of Microwave Sources and Parameter Scaling for High-Frequency Linacs. This report consists of three sections in which the progress for each task is documented separately. An introduction and synopsis is presented at the beginning of the progress report for each task

Study protocol

DEFF Research Database (Denmark)

Smith, Benjamin E; Hendrick, Paul; Bateman, Marcus

2017-01-01

avoidance behaviours, catastrophising, self-efficacy, sport and leisure activity participation, and general quality of life. Follow-up will be 3 and 6 months. The analysis will focus on descriptive statistics and confidence intervals. The qualitative components will follow a thematic analysis approach....... DISCUSSION: This study will evaluate the feasibility of running a definitive large-scale trial on patients with patellofemoral pain, within the NHS in the UK. We will identify strengths and weaknesses of the proposed protocol and the utility and characteristics of the outcome measures. The results from...... this study will inform the design of a multicentre trial. TRIAL REGISTRATION: ISRCTN35272486....

Plutonium storage study

International Nuclear Information System (INIS)

1979-01-01

This Spanish study gives a more detailed analysis of a possible store for plutonium oxide. The capacity of the store is assumed to be 30 t Pu and the minimum storage time 2 years. The study includes a general description of the store and its design philosophy; comments on the quality and properties of the material stored; a detailed criticality study and comments on gas and heat generation and shielding requirements; and a brief cost evaluation. Costs are estimated to be about $110/kg PuO 2 /year

Border region studies

DEFF Research Database (Denmark)

Makkonen, Teemu; Williams, Allan

2016-01-01

The contemporary conditions of academic capitalism exert pressures on researchers to avoid ‘peripheral’ journals and ‘unfashionable’ topics. Here an attempt is made to shed light onto the structure of one such ‘offbeat’ field, namely ‘border region studies’, by discussing its geographical...... distribution, key themes, significance and impact. The review suggests that border region studies can be considered a significant and important ‘branch’ of regional studies, which accounts for a small but increasing proportion of regional studies research particularly in Europe and North America. Four main...

Tokamak reactor studies

International Nuclear Information System (INIS)

Baker, C.C.

1981-01-01

This paper presents an overview of tokamak reactor studies with particular attention to commercial reactor concepts developed within the last three years. Emphasis is placed on DT fueled reactors for electricity production. A brief history of tokamak reactor studies is presented. The STARFIRE, NUWMAK, and HFCTR studies are highlighted. Recent developments that have increased the commercial attractiveness of tokamak reactor designs are discussed. These developments include smaller plant sizes, higher first wall loadings, improved maintenance concepts, steady-state operation, non-divertor particle control, and improved reactor safety features

International Active Surveillance Study of Women Taking Oral Contraceptives (INAS-OC Study).

Science.gov (United States)

Dinger, Juergen C; Bardenheuer, Kristina; Assmann, Anita

2009-11-18

A 24-day regimen of contraceptive doses of drospirenone and ethinylestradiol (DRSP/EE 24d) was recently launched. This regimen has properties which may be beneficial for certain user populations (e.g., women suffering from premenstrual dysphoric disorder or acne). However, it is unknown whether this extended regimen has an impact on the cardiovascular risk associated with the use of oral contraceptives (OCs). The INternational Active Surveillance study of women taking Oral Contraceptives (INAS-OC) is designed to investigate the short- and long-term safety of the new regimen in a population which is representative for the typical user of oral contraceptives. A large, prospective, controlled, non-interventional, long-term cohort study with active surveillance of the study participants has been chosen to ensure reliable and valid results. More than 2,000 gynecologists in the US and 5 European countries (Austria, Germany, Italy, Poland, and Sweden) will recruit more than 80,000 OC users. The two to five year follow-up of these women will result in at least 220,000 documented women-years. The main clinical outcomes of interest for the follow-up are deep venous thrombosis, pulmonary embolism, acute myocardial infarction and cerebrovascular accidents. Secondary objectives are general safety, effectiveness and drug utilization pattern of DRSP/EE 24d, return to fertility after stop of OC use, as well as the baseline risk for users of individual OC formulations. Because of the non-interference character of this study, potential participants (first-time users or switchers) are informed about the study only after the decision regarding prescription of a new OC. There are no specific medical inclusion or exclusion criteria. Study participation is voluntary and a written informed consent is required. After the baseline questionnaire, follow-up questionnaires will be mailed to the participants every 6 months for up to 5 years after baseline. Self-reported serious adverse events

Prolactinomas : clinical studies

NARCIS (Netherlands)

Kars, Marleen

2008-01-01

Prolactinoma are treated with dopamine agonists, which are effective in reducing prolactin and tumor size. Studies reporting clinical and radiological outcome are scarce. The study described in chapter 2, assesses long-term outcome in patients treated with dopamine agonists for macroprolactinoma. An

Accelerator research studies

International Nuclear Information System (INIS)

1993-01-01

The Accelerator Research Studies program at the University of Maryland, sponsored by the Department of Energy under grant number DE-FG05-91ER40642, is currently in the second year of a three-year funding cycle. The program consists of the following three tasks: TASK A, ''Study of Transport and Longitudinal Compression of Intense, High-Brightness Beams,'' (P.I., M. Reiser); TASK B, ''Study of Collective Ion Acceleration by Intense Electron Beams and Pseudospark Produced High Brightness Electron Beams,'' (Co-P.I.'s, W.W. Destler, M. Reiser, M.J. Rhee, and C.D. Striffler); TASK C, ''Study of a Gyroklystron High-Power Microwave Source for Linear Colliders,'' (Co-P.I.'s, V.L. Granatstein, W. Lawson, M. Reiser, and C.D. Striffler). In this report we document the progress that has been made during the past year for each of the three tasks

Thyroid function study

International Nuclear Information System (INIS)

Rocha, A.F.G. da

1976-01-01

A short revision of thyroid physiology is done. The radioisotopes of common use in thyroid investigation and the choice of the most appropriated ones are discussed. A table showing radioisotopes frequently used in this study, with their main characteristics is presented. Among several isotopic assays in thyroid propaedeutics, those that refer to the function study, topographic studies and tests 'in vitro' are pointed out. Exploration methods 'in vivo' are treated, such as: thyroid uptake; urinary excretion; thyroid scintigraphy, with scintigraphic imagings; stimulation test by TSH; suppression test; pbi; clearance test with perchlorate; iodine deficiency test and thyroid study with technetium. 'In vitro' proofs like triiodothyronine (T 3 ) and thyroxine (T 4 ) assays, as well as free thyroxine index, are treated. At last, the therapeutics by Iodine 131 is commented and emphasis is given to its application on the treatment of hyperthyroidism and thyroid carcinoma [pt

Making Media Studies

Directory of Open Access Journals (Sweden)

David Gauntlett

2015-12-01

Full Text Available This podcast is a recording of a research seminar that took place on December 3, 2015, at the University of Westminster's Communication and Media Research Institute (CAMRI. In this contribution, David Gauntlett discusses his new book, Making Media Studies, and other new work. In Making Media Studies (Peter Lang, 2015, Gauntlett proposes a vision of media studies based around doing and making – not about the acquisition of skills, as such, but an experience of building knowledge and understanding through creative hands-on engagement with all kinds of media. Gauntlett suggests that media studies scholars have failed to recognise the significance of everyday creativity – the vital drive of people to make, exchange, and learn together, supported by online networks. He argues that we should think about media in terms of conversations, inspirations, and making things happen. Media studies can be about genuine social change, he suggests, if we recognise the significance of everyday creativity, work to transform our tools, and learn to use them wisely. David Gauntlett is a Professor in the School of Media, Arts and Design at the University of Westminster, where he is also the School's Co-Director of Research. He is the author of several books, including: Creative Explorations (2007, Media, Gender and Identity: An Introduction (2nd edition 2008, Making is Connecting (2011, and Making Media Studies (2015. He has made a number of popular online resources, videos and playthings, and has pioneered creative research and workshop methods. He is external examiner for Information Experience Design at the Royal College of Art, London.

Portuguese Familial Hypercholesterolemia Study: presentation of the study and preliminary results.

Science.gov (United States)

Bourbon, Mafalda; Rato, Quitéria

2006-11-01

Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder caused, in the majority of cases, by a partial or total lack of functional low density lipoprotein receptors (LDLR). Mutations in the LDLR gene lead to increased plasma cholesterol levels, resulting in cholesterol deposition in the arteries, thereby increasing the risk of premature coronary heart disease. The homozygous form of FH is rare but heterozygous FH is common, although underdiagnosed in many populations, including the Portuguese. In 1999 the Portuguese Familial Hypercholesterolemia Study was begun at the National Institute of Health. The aim of the Portuguese Familial H ypercholesterolemia Study is to perform an epidemiological study to determine the prevalence and distribution of FH in Portugal and to better understand the pathophysiology of coronary heart disease in these patients. The aim of the present work is to present the study's criteria and organization as well as its preliminary results. The study population consists of individuals of both sexes and all ages with a clinical diagnosis of FH, with biochemical and molecular characterization being performed. The clinical criteria used for the diagnosis of FH were adapted from those of the Simon Broome Heart Research Trust. The study is organized in five stages: 1. selection of individuals with a clinical diagnosis of FH; 2. completion of a clinical questionnaire and declaration of informed consent; 3. collection of blood samples; 4. biochemical characterization; 5. molecular study of three genes associated with the FH phenotype: LDLR, apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9). Between 1999 and June 2006 the LDLR gene and the APOB gene of 141 index cases (38 children and 103 adults) were studied. In 78 of these index cases (76 heterozygotes and two homozygotes) 50 different mutations in the LDLR gene were identified, and two unrelated individuals were found to have the ApoB3500 mutation

Social Studies Teachers' Viewpoints of the Social Studies Lesson "Sample of Turkey and Afghanistan"

Science.gov (United States)

Sonmez, Omer Faruk

2014-01-01

This study was conducted to reveal the perceptions of history, geography and social studies teachers giving the social studies lesson at primary schools in Turkey and Afghanistan towards the social studies lesson. The working group of the study involves history, geography and social studies teachers rendering service in Tokat and Kayseri provinces…

Social Studies Oriented Achievement Goal Scale (SOAGS: Validity and Reliability Study

Directory of Open Access Journals (Sweden)

Melehat GEZER

2016-12-01

Full Text Available This study aims to develop a valid and reliable instrument for measuring students' social studies achievement goal. The research was conducted on a study group consisted of 374 middle school students studying in the central district of Diyarbakır in 2014-2015 school year fall semester. Expert opinion was consulted with regard to the scale's content and face validity. Exploratory Factor Analysis (EFA and Confirmatory Factor Analysis (CFA were performed in order to measure the scale's construct validity. As a result of EFA, a 29-item and a six-factor structure model which explains 50.82% of the total variance was obtained. The emerging factors were called as a self-approach, task-approach, other-approach, task-avoidance, other-avoidance and self-avoidance respectively. The findings acquired CFA indicated that the 29-item and six-factor structure related to social studies oriented achievement goal scale have acceptable goodness of fit indices. The scale's reliability coefficients were calculated by means of internal consistency method. As a result of reliability analysis, it was determined that the reliability coefficients were within admissible limits. The finding of the item correlation and 27% of upper and lower group comparisons demonstrated that all of the items in the scale should remain. In light of these results, it could be argued that the scale is reliable and valid instrument and can be used in order to test students' social studies achievement goals.

[Case and studies].

Science.gov (United States)

Schubert, András

2015-11-15

Case studies and case reports form an important and ever growing part of scientific and scholarly literature. The paper deals with the share and citation rate of these publication types on different fields of research. In general, evidence seems to support the opinion that an excessive number of such publications may negatively influence the impact factor of the journal. In the literature of scientometrics, case studies (at least the presence of the term "case study" in the titles of the papers) have a moderate share, but their citation rate is practically equal to that of other publication types.

Environmental health studies

International Nuclear Information System (INIS)

Easterly, C.E.; Shank, K.E.

1978-01-01

The two major thrusts of the environmental health studies have been in the areas of health physics aspects of fusion power and methodology for assessing health effects related to nuclear facilities. Researchers were unable to discern a dose-response relationship or to find adverse health effects in the local population around nuclear facilities which might be related to radiation exposure. A second study analyzed the trends in incidence of cancer, congenital malformation, and fetal and infant mortality for Oak Ridge, Anderson County, and Roane County relative to Tennessee. Finally, a more in-depth study on congenital malformations and fetal mortality trends for nine East Tennessee counties surrounding Oak Ridge was completed. The objective of the Health Physics Aspects of Fusion Power Program is to provide, on a timely basis, scientific information and technical evaluations on the potential impacts of fusion power to occupational workers and to members of the public. The primary areas of study in this program during the past year have been (1) factors affecting calculations of dose resulting from a release of tritium, (2) an assessment of the potential for reducing occupational risk from exposures to tritium, and (3) experimental studies of tritium conversion from molecular hydrogen to tritiated water

Studying the Atomic Nucleus - A New Era in Nuclear Structure Studies

International Nuclear Information System (INIS)

Casten, R. F.

2011-01-01

The study of atomic nuclei is part of the fascinating quest to understand the fundamental nature and origins of matter. This field, nuclear structure, is undergoing a revolutionary transformation that is breaking cherished paradigms, opening new vistas of nuclear matter for study, and which has the promise of leading to a new comprehensive understanding. The advent of new facilities for the production and study of exotic nuclei provides access to an entirely new territory of nuclei, and advances in extreme computing are enabling similar advances in the theory of atomic nuclei.

Optimum study designs.

Science.gov (United States)

Gu, C; Rao, D C

2001-01-01

Because simplistic designs will lead to prohibitively large sample sizes, the optimization of genetic study designs is critical for successfully mapping genes for complex diseases. Creative designs are necessary for detecting and amplifying the usually weak signals for complex traits. Two important outcomes of a study design--power and resolution--are implicitly tied together by the principle of uncertainty. Overemphasis on either one may lead to suboptimal designs. To achieve optimality for a particular study, therefore, practical measures such as cost-effectiveness must be used to strike a balance between power and resolution. In this light, the myriad of factors involved in study design can be checked for their effects on the ultimate outcomes, and the popular existing designs can be sorted into building blocks that may be useful for particular situations. It is hoped that imaginative construction of novel designs using such building blocks will lead to enhanced efficiency in finding genes for complex human traits.

Rockwell support studies

International Nuclear Information System (INIS)

Cadwell, L.L.

1980-01-01

Studies performed for the Rockwell Hanford Operations (RHO) were designed to either (1) identify the role of biota in the uptake and transport of radionuclides from low-level waste managemnt areas or (2) design and/or evaluate methods for reducing biological transport of radionuclides away from waste management areas. The completion and publication of documents reporting the results of previous studies was also emphasized this fiscal year. Field studies were designed to characterize insect and plant communities occupying low-level waste management areas and to evaluate pond ecosystem response to herbicide application. Laboratory studies involved the examination of (1) germination response in plant species proposed for surface stabilization on burial grounds, (2) a synthetic polymer matrix as a carrier and delivery system for phytotoxins to act as a barrier to plant root penetration of shallow-land low-level waste burial sites, and (3) factors responsible for differences in radionuclide availability to plants resulting from the chemical equilibration of radionuclides occurring under field conditions

Geomembrane special study

International Nuclear Information System (INIS)

1988-07-01

The objective of the Geomembrane Special Study was to asses the suitability of geomembranes in Uranium Mill Tailings Remedial Action (UMTRA) Project pile designs. Geomembranes, also called flexible membrane liners, are made of polymer resins and are thermoplastic materials. Part of the special study was to evaluate regulatory compliance and acceptability issues. This study was proposed because of the extensive use of geomembranes in hazardous waste site remedial actions and their accepted use in Resource Conservation and Recovery Act (RCRA) cells as both covers and liners to limit infiltration, or as part of leachate collection systems. This study has reviewed the recent geomembrane literature focusing on: (1) longevity; (2) performance; (3) constructibility; and (4) quality control/quality assurance considerations. In addition to these technical considerations, regulatory compliance and acceptability concerns were also evaluated. This report describes the results of the literature review, including correspondence with manufacturers, resin producers, experts in the field, and long-term major users. 12 refs., 2 tabs

Children Rights in Social Studies Curricula in Elementary Education: A Comparative Study

Science.gov (United States)

Merey, Zihni

2012-01-01

Social studies classes educate students as citizens who are expected to adopt democratic values and apply their information and richness to their life. Social studies classes are the ones that include human rights education in the first place. The purpose of this study is to make a comparison of inclusion levels of children's rights issues in…

How Turkish Middle School Students Use the Internet to Study Social Studies

Science.gov (United States)

Acikalin, Mehmet

2014-01-01

The Internet has become one of the most common educational tools used by teachers and students in social studies education worldwide. Although there are extensive studies on how the Internet is used by teachers as an instructional tool in social studies classes, less work has been done to explain how students themselves use and interact with…

International Active Surveillance Study of Women Taking Oral Contraceptives (INAS-OC Study

Directory of Open Access Journals (Sweden)

Assmann Anita

2009-11-01

Full Text Available Abstract Background A 24-day regimen of contraceptive doses of drospirenone and ethinylestradiol (DRSP/EE 24d was recently launched. This regimen has properties which may be beneficial for certain user populations (e.g., women suffering from premenstrual dysphoric disorder or acne. However, it is unknown whether this extended regimen has an impact on the cardiovascular risk associated with the use of oral contraceptives (OCs. The INternational Active Surveillance study of women taking Oral Contraceptives (INAS-OC is designed to investigate the short- and long-term safety of the new regimen in a population which is representative for the typical user of oral contraceptives. Methods/Design A large, prospective, controlled, non-interventional, long-term cohort study with active surveillance of the study participants has been chosen to ensure reliable and valid results. More than 2,000 gynecologists in the US and 5 European countries (Austria, Germany, Italy, Poland, and Sweden will recruit more than 80,000 OC users. The two to five year follow-up of these women will result in at least 220,000 documented women-years. The main clinical outcomes of interest for the follow-up are deep venous thrombosis, pulmonary embolism, acute myocardial infarction and cerebrovascular accidents. Secondary objectives are general safety, effectiveness and drug utilization pattern of DRSP/EE 24d, return to fertility after stop of OC use, as well as the baseline risk for users of individual OC formulations. Because of the non-interference character of this study, potential participants (first-time users or switchers are informed about the study only after the decision regarding prescription of a new OC. There are no specific medical inclusion or exclusion criteria. Study participation is voluntary and a written informed consent is required. After the baseline questionnaire, follow-up questionnaires will be mailed to the participants every 6 months for up to 5 years after

Jabiluka environmental studies

Energy Technology Data Exchange (ETDEWEB)

Morley, A.W.; Koontz, D.V.; Sanderson, N.T. (Pancontinental Mining Ltd., Sydney (Australia))

1984-02-01

Environmental baseline studies associated with development of the Jabiluka uranium deposits are described. Some basic characteristics of the area local to the deposits are reported and a brief explanation is provided of the nature of, and philosophy behind the environmental studies. The major findings from this program are discussed.

The INTERPHONE study: design, epidemiological methods, and description of the study population

DEFF Research Database (Denmark)

Cardis, Elisabeth; Richardson, Lesley; Deltour, Isabelle

2007-01-01

. This paper describes the study design and methods and the main characteristics of the study population. INTERPHONE is the largest case-control study to date investigating risks related to mobile phone use and to other potential risk factors for the tumours of interest and includes 2,765 glioma, 2......The very rapid worldwide increase in mobile phone use in the last decade has generated considerable interest in the possible health effects of exposure to radio frequency (RF) fields. A multinational case-control study, INTERPHONE, was set-up to investigate whether mobile phone use increases...... the risk of cancer and, more specifically, whether the RF fields emitted by mobile phones are carcinogenic. The study focused on tumours arising in the tissues most exposed to RF fields from mobile phones: glioma, meningioma, acoustic neurinoma and parotid gland tumours. In addition to a detailed history...

Improving the analysis of designed studies by combining statistical modelling with study design information

NARCIS (Netherlands)

Thissen, U.; Wopereis, S.; Berg, S.A.A. van den; Bobeldijk, I.; Kleemann, R.; Kooistra, T.; Dijk, K.W. van; Ommen, B. van; Smilde, A.K.

2009-01-01

Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study

Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos

OpenAIRE

Sofer, Tamar; Wong, Quenna; Hartwig, Fernando P.; Taylor, Kent; Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Levy, Daniel; Kramer, Holly; Lange, Leslie A.; Horta, Bernardo L.; Liang, Jingjing; Le, Thu H.; Edwards, Digna R. Velez; Tayo, Bamidele O.

2017-01-01

Hypertension prevalence varies between ethnic groups, possibly due to differences in genetic, environmental, and cultural determinants. Hispanic/Latino Americans are a diverse and understudied population. We performed a genome-wide association study (GWAS) of blood pressure (BP) traits in 12,278 participants from the Hispanics Community Health Study/Study of Latinos (HCHS/SOL). In the discovery phase we identified eight previously unreported BP loci. In the replication stage, we tested these ...

Theorizing Iberian Studies

Science.gov (United States)

Newcomb, Robert Patrick

2015-01-01

A growing number of scholars invested in Iberian Studies are asking how peninsular literary and cultural studies might be reimagined, and reinvigorated, by placing the Spanish and Portuguese canons into critical dialogue with each other, and with Galician, Catalan, Basque/Euskadi, and Latin American and North African immigrant writers, cultural…

Aquatic biology studies

International Nuclear Information System (INIS)

Anon.

1976-01-01

Aquatic biology studies focused on studying the hydrothermal effects of Par Pond reservoir on periphyton, plankton, zooplankton, macrophytes, human pathogens, and microbial activity; the variability between the artificial streams of the Flowing Streams Laboratory and Upper Three Runs Creek; and the bacterial production of methane in Savannah River Plant aquatic systems

Jabiluka environmental studies

International Nuclear Information System (INIS)

Morley, A.W.; Koontz, D.V.; Sanderson, N.T.

1984-01-01

Environmental baseline studies associated with development of the Jabiluka uranium deposits are described. Some basic characteristics of the area local to the deposits are reported and a brief explanation is provided of the nature of, and philosophy behind the environmental studies. The major findings from this program are discussed. (author)

Designing satisfaction studies

DEFF Research Database (Denmark)

Kristensen, Kai; Eskildsen, Jacob Kjær

2007-01-01

In the effect sampling method, presentation of researcher, the intro text, the order of questions in the questionnaire along with the number of categories in the rating scale is tested in relation to the design of satisfaction studies. Based on the analyses specific recommendations for designing...... satisfaction studies are given....

The Sports-Related Injuries and Illnesses in Paralympic Sport Study (SRIIPSS): a study protocol for a prospective longitudinal study.

Science.gov (United States)

Fagher, Kristina; Jacobsson, Jenny; Timpka, Toomas; Dahlström, Örjan; Lexell, Jan

2016-01-01

Paralympic sport provides sporting opportunities for athletes with a disability, with the Paralympic Games as the main event. Participation in sport is, however, associated with a significant risk for sustaining injuries and illnesses. Our knowledge of sports-related injuries and illnesses in Paralympic sport is very limited and there are no large-scale epidemiological cohort studies. The purpose here is to present a protocol for a prospective longitudinal study: The Sports-Related Injuries and Illnesses in Paralympic Sport Study (SRIIPSS). An argument-based method for investigation of design problems was used to structure the study protocol. The primary requirement of the protocol is to allow prospective studies over time and include exposure to both training and competition. To reflect the complexity of Paralympic sport with athletes' pre-existing impairments, use of assistive equipment, pain and other and medical issues, it is required that the data collection system is specifically adapted to Paralympic sport. To allow the collection of data, at the same time as there is limited access to coaches and medical personnel, it is advantageous that data can be collected online directly from the athletes. Based on this a self-report athlete monitoring system will be developed, where the athletes can enter data weekly via their mobile phones or lap-tops. Data will be collected from around 100 Swedish Paralympic athletes for approximately 1 year, which will allow us to i) prospectively estimate the annual incidence of sports-related injuries and illnesses and ii) explore risk factors and mechanisms for sustaining sports-related injuries and illnesses based on athlete exposure and training loads. For effective implementation of injury and illness prevention measures, comprehensive epidemiological knowledge is required. This study will be the first prospective longitudinal self-report study of sports-related injuries and illnesses in Paralympic sport over a longer period

Human exploration mission studies

Science.gov (United States)

Cataldo, Robert L.

1989-01-01

The Office of Exploration has established a process whereby all NASA field centers and other NASA Headquarters offices participate in the formulation and analysis of a wide range of mission strategies. These strategies were manifested into specific scenarios or candidate case studies. The case studies provided a systematic approach into analyzing each mission element. First, each case study must address several major themes and rationale including: national pride and international prestige, advancement of scientific knowledge, a catalyst for technology, economic benefits, space enterprise, international cooperation, and education and excellence. Second, the set of candidate case studies are formulated to encompass the technology requirement limits in the life sciences, launch capabilities, space transfer, automation, and robotics in space operations, power, and propulsion. The first set of reference case studies identify three major strategies: human expeditions, science outposts, and evolutionary expansion. During the past year, four case studies were examined to explore these strategies. The expeditionary missions include the Human Expedition to Phobos and Human Expedition to Mars case studies. The Lunar Observatory and Lunar Outpost to Early Mars Evolution case studies examined the later two strategies. This set of case studies established the framework to perform detailed mission analysis and system engineering to define a host of concepts and requirements for various space systems and advanced technologies. The details of each mission are described and, specifically, the results affecting the advanced technologies required to accomplish each mission scenario are presented.

Low frequency noise study.

Science.gov (United States)

2007-04-01

This report documents a study to investigate human response to the low-frequency : content of aviation noise, or low-frequency noise (LFN). The study comprised field : measurements and laboratory studies. The major findings were: : 1. Start-of-takeof...

The CAIRO4 study

DEFF Research Database (Denmark)

't Lam-Boer, Jorine; Mol, Linda; Verhoef, Cornelis

2015-01-01

stages of the disease. We here propose a randomized trial in order to demonstrate that resection of the primary tumour improves overall survival. METHODS/DESIGN: The CAIRO4 study is a multicentre, randomized, phase III study of the Dutch Colorectal Cancer Group (DCCG). Patients with synchronous...... objective of this study is to determine the clinical benefit in terms of overall survival of initial resection of the primary tumour. Secondary endpoints include progression free survival, surgical morbidity, quality of life and the number of patients requiring resection of the primary tumour in the control...... arm. DISCUSSION: The CAIRO4 study is a multicentre, randomized, phase III study that will assess the benefit of resection of the primary tumour in patients with synchronous metastatic CRC. TRIAL REGISTRATION: The CAIRO4 study is registered at clinicaltrials.gov (NCT01606098)....

Fusion energy studies

International Nuclear Information System (INIS)

Anon.

1977-01-01

Current experimental efforts are aimed toward developing cryosorption vacuum pumps for removing unburned fuel and impurities from the plasma, studying deep-bed sorption pumps for roughing and transfer operations, investigating methods for recovery of tritium bred in blankets of lithium or lithium alloys, and studying containment of tritium that permeates metal walls

Study protocol. The Childhood Health, Activity, and Motor Performance School Study Denmark (The CHAMPS-study DK

Directory of Open Access Journals (Sweden)

Wedderkopp Niels

2012-08-01

Full Text Available Abstract Background An increasingly passive life-style in the Western World has led to a rise in life-style related disorders. This is a major concern for all segments of society. The county council of the municipality of Svendborg in Denmark, created six Sport Schools with increased levels of suitable physical activities, which made it possible to study the health outcomes in these children whilst comparing them to children who attended the ‘normal’ schools of the region using the design of a “natural experiment”. Methods Children from the age of 6 till the age of 10, who accepted to be included in the monitoring process, were surveyed at baseline with questionnaires, physical examinations and physical and biological testing, including DXA scans. The physical examination and testing was repeated during the early stage of the study. Every week over the whole study period, the children will be followed with an automated mobile phone text message (SMS-Track asking questions on their leisure time sports activities and the presence of any musculoskeletal problems. Children who report any such problems are monitored individually by health care personnel. Data are collected on demography, health habits and attitudes, physical characteristics, physical activity using accelerometers, motor performance, fitness, bone health, life-style disorders, injuries and musculoskeletal problems. Data collection will continue at least once a year until the children reach grade 9. Discussion This project is embedded in a local community, which set up the intervention (The Sport Schools and thereafter invited researchers to provide documentation and evaluation. Sport schools are well matched with the ‘normal’ schools, making comparisons between these suitable. However, subgroups that would be specifically targeted in lifestyle intervention studies (such as the definitely obese could be relatively small. Therefore, results specific to minority groups may be

Study protocol. The Childhood Health, Activity, and Motor Performance School Study Denmark (The CHAMPS-study DK).

Science.gov (United States)

Wedderkopp, Niels; Jespersen, Eva; Franz, Claudia; Klakk, Heidi; Heidemann, Malene; Christiansen, Christina; Møller, Niels Christian; Leboeuf-Yde, Charlotte

2012-08-20

An increasingly passive life-style in the Western World has led to a rise in life-style related disorders. This is a major concern for all segments of society. The county council of the municipality of Svendborg in Denmark, created six Sport Schools with increased levels of suitable physical activities, which made it possible to study the health outcomes in these children whilst comparing them to children who attended the 'normal' schools of the region using the design of a "natural experiment". Children from the age of 6 till the age of 10, who accepted to be included in the monitoring process, were surveyed at baseline with questionnaires, physical examinations and physical and biological testing, including DXA scans. The physical examination and testing was repeated during the early stage of the study. Every week over the whole study period, the children will be followed with an automated mobile phone text message (SMS-Track) asking questions on their leisure time sports activities and the presence of any musculoskeletal problems. Children who report any such problems are monitored individually by health care personnel. Data are collected on demography, health habits and attitudes, physical characteristics, physical activity using accelerometers, motor performance, fitness, bone health, life-style disorders, injuries and musculoskeletal problems. Data collection will continue at least once a year until the children reach grade 9. This project is embedded in a local community, which set up the intervention (The Sport Schools) and thereafter invited researchers to provide documentation and evaluation. Sport schools are well matched with the 'normal' schools, making comparisons between these suitable. However, subgroups that would be specifically targeted in lifestyle intervention studies (such as the definitely obese) could be relatively small. Therefore, results specific to minority groups may be diluted. Nonetheless, the many rigorously collected data will make

Cost-of-illness studies.

Science.gov (United States)

Oderda, Gary M

2003-01-01

Cost-of-illness studies measure the overall economic impact of a disease on society. Such studies are important in setting public health priorities and for economic evaluation of new treatments. These studies should take the societal perspective and include both direct and indirect costs. Often indirect costs exceed direct costs. Comparison of cost-of-illness studies from different countries is difficult because of differences in population, currency, the way health care is provided, and other social and political factors.

The Association of Parental/Caregiver Chronic Stress with Youth Obesity: Findings from the Study of Latino Youth and the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.

Science.gov (United States)

Isasi, Carmen R; Hua, Simin; Jung, Molly; Carnethon, Mercedes R; Perreira, Krista; Vidot, Denise C; Salazar, Christian R; McCurley, Jessica L; Sotres-Alvarez, Daniela; Van Horn, Linda; Delamater, Alan M; Llabre, Maria M; Gallo, Linda C

2017-08-01

Prior studies indicate that chronic stress is associated with obesity in adults. However, whether parental/caregiver stress is associated with obesity in their offspring has not been widely examined in Hispanic/Latino populations. In this study, we evaluated the role of caregiver chronic stress on child obesity and whether home food environment or child lifestyle behaviors explained the association. The study included a sample of Hispanic/Latino youth and their caregivers (n = 473) from the Study of Latinos (SOL) Youth study and the Hispanic Community Health Study/SOL Sociocultural Study, which enrolled children aged 8-16 years from four cities (Bronx, Chicago, Miami, and San Diego), and provided assessments of adult chronic stress. Poisson regression models were used to assess the association between parental/caregiver stress and child obesity, adjusting for potential confounders. Twenty-two percent of caregivers did not report any chronic stressors, 48% reported 1-2, and 29% reported ≥3 stressors. The prevalence of obesity in youth increased with number of caregiver stressors from 23% among those without caregiver stressors to 35% among those with ≥3 stressors (p for trend 0.03). After model adjustment, youths whose caregivers reported ≥3 stressors were more likely to be obese than youths whose caregivers reported no stressors (prevalence ratio = 1.53; 95% confidence interval 1.01-2.32). This association was independent of food home environment, child diet quality, and child physical activity, but it was not independent of caregiver obesity. These findings suggest that parental/caregiver chronic stress is related to obesity in their children. Future research is needed to confirm this association in longitudinal studies and in other population groups.

Responses of Study Abroad Students in Australia to Experience-Based Pedagogy in Sport Studies

Science.gov (United States)

Light, Richard; Georgakis, Steve

2008-01-01

This paper contributes to research on the scholarship of teaching in the physical education/sport studies fields by examining the responses of study abroad students from overseas studying in Australia to a unit of study in sport studies that placed the interpretation of experience as the centre of the learning process. It draws on research…

Selling the Social Studies.

Science.gov (United States)

Girod, Gerald R.; Harmon, Gerald R.

1987-01-01

Maintains school-aged children would prefer not to study social studies. Presents several strategies to help encourage positive attitudes. Strategies include persuasion, reinforcement, enthusiasm, personalized contact. Stresses that negative attitudes must be changed in order for social studies to achieve its fundamental citizenship goals. (BR)

Ca-48 metabolism studies

International Nuclear Information System (INIS)

Van der Merwe, D.G.

1987-03-01

Calcium metabolism has been studied in depth physiologically and is a relatively well-understood element in biochemistry and medicine. There is still only restricted knowledge of the metabolic fate of calcium in normal and abnormal paediatric subjects. The latter is partially owing to inadequate techniques for tracing and modelling calcium pathways in children. The advent of radioactive tracers has unquestionably enhanced medical research and improved the quality of many metabolic studies. The present study was aimed at the development, promotion and justification of a new tracer technique using the stable isotope, calcium-48. The obvious advantages of such a technique are its harmlessness tothe subject, its applicability to both short- and long-term studies as well as its usefulness to the study for which it was originally motivated, viz research defining the actual relationship between a calcium-deficient diet and the occurrence of rickets in rural Black children in South Africa. Exploratory instrumental analyses were performed specifically with serum samples. This proved successful enough to develop a less specific pre-concentration technique which improved the sensitivity and reduces the cost of doing calcium-48 metabolism studies. The results of a simple metabolic study are presented whereby the scope of the technique is demonstrated in a real situation. The possibilities and limitations of double-isotope metabolic studies are discussed, particularly with regard to strontium as the second tracer

The Tromsø Eye Study

DEFF Research Database (Denmark)

Bertelsen, Geir; Erke, Maja G; von Hanno, Therese

2013-01-01

Purpose:  To describe the study design and methodology of the Tromsø Eye Study (TES), and to describe visual acuity and refractive error in the study population. Methods:  The Tromsø Eye Study is a sub-study of the Tromsø Study, a population-based multipurpose longitudinal study in the municipality...... of Tromsø, Norway. The Tromsø Eye Study was a part of the sixth survey of the Tromsø Study, conducted from October 2007 through December 2008. The eye examination included information on self-reported eye diseases, assessment of visual acuity and refractive errors, retinal photography and optical coherence...

A Place for Project Management in English Studies and Communication studies  curricula

DEFF Research Database (Denmark)

Kampf, Constance; Isohella, Suvi

2009-01-01

In this paper, we argue for a place for project management in the English Studies and Communication Studies curricula, often the home of Technical Communication programs, in order to offer students an opportunity to apply their language, discourse analysis, analytical skills, and creativity in a ...... of the project management genres are briefly discussed and related to key skills emerging from English studies and Technical Communication curricula.......In this paper, we argue for a place for project management in the English Studies and Communication Studies curricula, often the home of Technical Communication programs, in order to offer students an opportunity to apply their language, discourse analysis, analytical skills, and creativity...

The Importance of Pilot Studies

OpenAIRE

Van Teijlingen, Edwin; Hundley, Vanora

2001-01-01

The term 'pilot studies' refers to mini versions of a full-scale study (also called 'feasibility' studies), as well as the specific pre-testing of a particular research instrument such as a questionnaire or interview schedule. \\ud Pilot studies are a crucial element of a good study design. Conducting a pilot study does not guarantee success in the main study, but it does increase the likelihood. \\ud Pilot studies fulfil a range of important functions and can provide valuable insights for othe...

EUDAT strategies for handling dynamic data in the solid Earth Sciences

Science.gov (United States)

Michelini, Alberto; Evans, Peter; Kemps-Snijder, Mark; Heikkinen, Jani; Buck, Justin; Misutka, Jozef; Drude, Sebastian; Fares, Massimo; Cacciari, Claudio; Fiameni, Giuseppe

2014-05-01

of data, and a complete data set may contain many streams. It is important to distinguish between "observation time" (or measurement time, MT), at which a measurement is made and "access time" (or state time, ST, or ingestion time), at which data arrived in this database system. Granularity in time is the third ingredient and it mainly refers to reproducibility: is there a requirement to distinguish between states a few seconds, minutes, days apart? This time may be as small as the time between successive samples. Granularity relates to accountability. We present a possible solution which stems on representing each observation in a dynamic data stream by a point in the bi-temporal space defined by (MT, ST) corresponding to the time at which the data arrived and the time to which it refers. Features of dynamic data such as latency and gaps can then be visualised: delays in arrival of the data (latency) move observations down from the line labelled "real time", while missing values (gaps) cause the sequence of observations to jump to the right. Revisions of values at one or more time appear below the original values.

Study deep geothermal energy; Studie dypgeotermisk energi

Energy Technology Data Exchange (ETDEWEB)

Havellen, Vidar; Eri, Lars Sigurd; Andersen, Andreas; Tuttle, Kevin J.; Ruden, Dorottya Bartucz; Ruden, Fridtjof; Rigler, Balazs; Pascal, Christophe; Larsen, Bjoern Tore

2012-07-01

The study aims to analyze the potential energy with current technology, challenges, issues and opportunities for deep geothermal energy using quantitative analysis. It should especially be made to identify and investigate critical connections between geothermal potential, the size of the heating requirements and technical solutions. Examples of critical relationships may be acceptable cost of technology in relation to heating, local geothermal gradient / drilling depth / temperature levels and profitability. (eb)

76 FR 23605 - New Proposed Collection; Comment Request; Study Logistic Formative Research Methodology Studies...

Science.gov (United States)

2011-04-27

...; Comment Request; Study Logistic Formative Research Methodology Studies for the National Children's Study... maximize the efficiency (measured by scientific robustness, participant and infrastructure burden, and cost... assess the feasibility, acceptability, and cost of the recruitment strategy, study procedures, and...

Conference Essay: The Relationship between Gender Studies and Discourse Studies: Synergies, Frictions, and Pitfalls

OpenAIRE

Kleiner, Bettina; Dinsleder, Cornelia

2017-01-01

The interdisciplinary conference "Gender Studies Meets Discourse Studies Meets Gender Studies: Entanglements, Affinities, Tensions, and Open Questions" focused on the relationship between gender studies and discourse studies. On the one hand this essay provides insights into the conference debates, and on the other it critically discusses the contributions. The following three key aspects provide guidelines for reconstructing and developing the arguments: 1. theoretical perspectives on the re...

The study of negotiation activities in foreign studies

Directory of Open Access Journals (Sweden)

Vahnina V.V.

2016-06-01

Full Text Available The article is devoted to the problem of studying the negotiation activities of foreign scientists. There are different trends in the study of negotiations law enforcement officers in crisis situations and the possibilities of overcoming and prevention of crisis negotiations. The author explores the different approaches of foreign scientists to the problem of negotiation in crisis situations involving the Commission of a crime. The author particularly notes the work of Slovak researchers who formed the Bank crises and analyzed the possibilities of overcoming the crisis conditions of the negotiation activities. In the article the results of research activities of scientists not only theorists but also practitioners. The leaders of the special units involved in the liberation of hostages, analyze the causes of crisis negotiations and the possibility of its overcoming. The analysis of the presented approaches allows foreign scientists to develop the concept of anti-crisis talks of employees of internal Affairs bodies and the perpetrators (the perpetrators of criminal acts.

Mars power system concept definition study. Volume 1: Study results

Science.gov (United States)

Littman, Franklin D.

1994-01-01

A preliminary top level study was completed to define power system concepts applicable to Mars surface applications. This effort included definition of power system requirements and selection of power systems with the potential for high commonality. These power systems included dynamic isotope, Proton Exchange Membrane (PEM) regenerative fuel cell, sodium sulfur battery, photovoltaic, and reactor concepts. Design influencing factors were identified. Characterization studies were then done for each concept to determine system performance, size/volume, and mass. Operations studies were done to determine emplacement/deployment maintenance/servicing, and startup/shutdown requirements. Technology development roadmaps were written for each candidate power system (included in Volume 2). Example power system architectures were defined and compared on a mass basis. The dynamic isotope power system and nuclear reactor power system architectures had significantly lower total masses than the photovoltaic system architectures. Integrated development and deployment time phasing plans were completed for an example DIPS and reactor architecture option to determine the development strategies required to meet the mission scenario requirements.

Learning Center and Study Carrels: A Comparative Study. Technical Report #18.

Science.gov (United States)

Chun, Sherlyn; And Others

This Kamehameha Early Education Program (KEEP) report presents a comparative study of the work rates of kindergarten and first grade children in two classroom environments: a learning-center and a study-carrel environment. The subjects, seven matched pairs of kindergarten and first grade students, were chosen on the basis of the results of a…

Tromsø eye study

DEFF Research Database (Denmark)

Bertelsen, Geir; Peto, Tunde; Lindekleiv, Haakon

2013-01-01

Purpose:  To determine the prevalence of visual impairment, retinopathy and macular oedema, and assess risk factors for retinopathy in persons with diabetes. Methods:  The present study included 514 participants with diabetes aged 46-87 years from the Tromsø Eye Study, a sub-study of the population......-based Tromsø Study in Norway. Visual acuity was measured using an auto-refractor. Retinal images from both eyes were graded for retinopathy and macular oedema. We collected data on risk factor exposure from self-report questionnaires, clinical examinations, laboratory measurements and case note reviews...

Study Groups in Denmark

DEFF Research Database (Denmark)

Hjorth, Poul G.

2007-01-01

Since 1998 European Study Groups have been held in Denmark, and Danish companies from LEGO and NOVO to very small high-tech firms have participated. I briefly describe the history, the organisation and the format of the Danish Study Groups, and highlight a few problem solutions.......Since 1998 European Study Groups have been held in Denmark, and Danish companies from LEGO and NOVO to very small high-tech firms have participated. I briefly describe the history, the organisation and the format of the Danish Study Groups, and highlight a few problem solutions....

Adapting Parcellation Schemes to Study Fetal Brain Connectivity in Serial Imaging Studies

DEFF Research Database (Denmark)

Cheng, Xi; Wilm, Jakob; Seshamani, Sharmishtaa

2013-01-01

A crucial step in studying brain connectivity is the definition of the Regions Of Interest (ROI's) which are considered as nodes of a network graph. These ROI's identified in structural imaging reflect consistent functional regions in the anatomies being compared. However in serial studies...... of the developing fetal brain such functional and associated structural markers are not consistently present over time. In this study we adapt two non-atlas based parcellation schemes to study the development of connectivity networks of a fetal monkey brain using Diffusion Weighted Imaging techniques. Results...... demonstrate that the fetal brain network exhibits small-world characteristics and a pattern of increased cluster coefficients and decreased global efficiency. These findings may provide a route to creating a new biomarker for healthy fetal brain development....

Women, Co-occurring Disorders, and Violence Study: evaluation design and study population.

Science.gov (United States)

McHugo, G J; Kammerer, N; Jackson, E W; Markoff, L S; Gatz, M; Larson, M J; Mazelis, R; Hennigan, K

2005-03-01

The Women, Co-occurring Disorders, and Violence Study (WCDVS) was a multi-site cooperative study to evaluate new service models for women with co-occurring mental health and substance use disorders and a history of physical and/or sexual abuse. Despite common features in the service interventions and evaluation procedures, diversity across the nine sites plus differences introduced by non-random assignment led to numerous methodological challenges. This article describes the design, measurement, and analysis decisions behind the WCDVS and lays the foundation for understanding participant-level outcomes and service costs. This article also describes the study population, as recruited and following attrition at the 6-month follow-up, in order to address the threat of selection bias to inferences drawn from this multi-site study.

BioFleet case studies

International Nuclear Information System (INIS)

2007-01-01

These six case studies examined the use of different biodiesel blends as fuel supply sources for businesses in British Columbia (BC). In the first case study, 6 municipalities participated in a pilot program designed to compare the performance of biodiesel and diesel fuels. Each municipality operated 2 base vehicles running on conventional diesel along with 2 similar vehicles which used biodiesel. Real time emissions tests and analyses of the vehicles using biodiesel were also conducted by 2 of the participating municipalities. All municipalities participating in the study agreed to purchase significant volumes of biodiesel. The second case study described a pilot study conducted by the City of Vancouver's equipment services branch in 2004. As a result of the study, the city now has over 530 types of equipment that use biodiesel. The third case study described a program designed by TSI Terminals in Vancouver to assess the emission reduction impact of using biodiesel at its port facility. Six different pieces of equipment were used to confirm that biodiesel could be used throughout the terminal. Test results confirmed that biodiesel blends could be used to reduce emissions. Overall emissions were reduced by 30 per cent. The fourth case study described a waste renderer that used a fleet of 36 trucks to deliver raw products to its plants. The company made the decision to use only biodiesel for its entire fleet of trucks. Since July 2005, the company has logged over 1.7 million km using biodiesel blends. The fifth case study described a salmon hatchery that switched from diesel to biodiesel in order to reduce emissions. The biodiesel blends are used to fuel the hatchery's 2 diesel generators. The hatchery has reduced emissions of greenhouse gases (GHGs) by an estimated 1800 tonnes annually. The sixth case study described how the Township of Langley has started using biodiesel for its entire fleet of of approximately 250 pieces of equipment. The township has not

Environmental studies

International Nuclear Information System (INIS)

Mohd Tadza Abd Rahman

2003-01-01

Nuclear Technology offers unique method, yet effective for environmental research. Nuclear techniques are invented to carry out research activities on environmental pollutions, erosion and slope stability, landslide ground water studies and water pollution

Floodplain Study

Data.gov (United States)

Montgomery County of Maryland — The purpose of a floodplain study is to establish the 100-year floodplain limits within or near a development in order to preserve the natural resources within the...

Belgrade metro studies

Directory of Open Access Journals (Sweden)

Biljana Arandjelović

2009-01-01

Full Text Available The subway system is an indispensable part of every modern metropolis. Building a subway is no longer a matter of prestige but a necessity, a consequence of the traffic revolution worldwide. This paper shows four metro studies with specific reference to the Belgrade subway and problems that occurred. The first one was conducted in 1946 by the famous Serbian architect Nikola Dobrovic. This document is indeed the first written record discussing the subway issue in Belgrade. The next study dates back to 1968. This project was the first major study on the possibility of a subway. The third and biggest, this subway study was completed in 1982 and contained a major and comprehensive subway project. This project was officially accepted and enacted by the city government. The fourth project in circulation with regard to the subway is the light city railway project. It came out due to the consequences of the decision that a classical subway was not necessary in Belgrade, so that a replacement for the classical subway system was to be undertaken. The light city railway project was adopted as a part of the General Urban Plan for Belgrade by the year 2021.

Critical Digital Tourism Studies

DEFF Research Database (Denmark)

Gyimóthy, Szilvia; Munar, Ana María

2013-01-01

This paper advocates the need for a critical and cross-disciplinary research agenda on the field of digital technologies and tourism. The changing virtual landscape of tourism has received increased attention by tourism scholars. However, contemporary studies on information technologies (IT......) are approached mostly from a business administration perspective and informed by conceptual frameworks developed in management and marketing. IT studies in tourism are still at a stage similar to the first advocacy phase of tourism research in general (Jafari, 1990) and are seldom inspired by relevant...... to studying digital socio-technical systems and virtual mediation in tourism. Critical Digital Tourism Studies opens a new cross-disciplinary field where the sociality of virtual tourism interactions is examined (entailing the study of structures, social rules, ideologies, power relations, sustainability...

Summary of Utility Studies: Smart Grid Investment Grant Consumer Behavior Study Analysis

Energy Technology Data Exchange (ETDEWEB)

Cappers, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Todd, Annika [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Goldamn, Charles A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2013-05-01

The U.S. Department of Energy’s (DOE’s) Smart Grid Investment Grant (SGIG) program is working with a subset of the 99 SGIG projects to assess the response of mass market consumers (i.e., residential and small commercial customers) to time-varying electricity prices (referred to herein as time-based rate programs) in conjunction with the deployment of advanced metering infrastructure (AMI) and associated technologies. The effort provides an opportunity to advance the electric industry’s understanding of consumer behavior. In addition, DOE is attempting to apply a consistent study design and analysis framework for the SGIG Consumer Behavior Studies (CBS). The aim is to collect information across the studies on variables and impacts that have been defined in a consistent manner. This will enable Lawrence Berkeley National Lab (LBNL), as DOE’s principal investigator for these Consumer Behavior Studies, to leverage the data from the individual studies and conduct comparative analysis of the impacts of AMI, time-based rate programs and enabling technologies that facilitate customer control, automation and information/feedback on customer energy usage.

The Role of Eportfolios in Finance Studies: A Cross-Country Study

Science.gov (United States)

Domínguez, Amparo S.; Morales, Lucía; Tarkovska, Valentina

2014-01-01

This study explores the use of ePortfolios as an efficient assessment tool to support students pursuing a Business degree, where Finance is a major component. We conducted an analysis on the role of ePortfolios in Higher Education at Dublin Institute of Technology (Republic of Ireland) and at Universitat Jaume I (Spain) for undergraduate studies.…

Building Transdisciplinary Environmental Studies

DEFF Research Database (Denmark)

Holm, Jesper

2006-01-01

Conceptual analytical-methodological conceptualization of crossdisciplinary sustainability studies......Conceptual analytical-methodological conceptualization of crossdisciplinary sustainability studies...

Cerebral perfution studies

International Nuclear Information System (INIS)

Mut, Fernando

1994-01-01

For detecting in precocious form a coronary disease is necessary to aply a diagnostic techniques. The main considerations to be indicated in the present work are: physiological considerations, myocardial perfusion studies with radiotracers such as Talio 201, 99mTc, MIBI, 99mTc-Teboroxima, 99mTc-Fosfinas, instrumentation for obtain good images, proceedings protocols, studies interpretation, standards, SPECT, anomalies standards, coronary diseases

University related studies

International Nuclear Information System (INIS)

Anon.

1976-01-01

Over the years, opportunities for terrestrial ecology studies have attracted student researchers associated with Pacific Northwest colleges and universities. During the past year, four students have been involved with undergraduate or graduate thesis projects. Brief descriptions of these studies are included in this section. It is expected that university participation will be enhanced by designating parts of the Hanford Reservation as a National Environmental Research Park (NERP)

Pilot study

International Nuclear Information System (INIS)

Hofmeester, G.H.; Swart, A.; Dijk, E. van

1984-01-01

In May 1980 it was decided to organize an intercomparison of personal dosimeters for photon radiations. The Commission of the European Communities initiated the intercomparison by starting a pilot study in which three laboratories NPL (United Kingdom), PTB (Germany) and RIV (The Netherlands) were asked to irradiate a series of personal dosemeters from institutes, GSF (Muenchen), CEA (Fontenay-aux-Roses), CNEN (Bologna) and CEGB (Berkeley). The latter institutes are secondary standard laboratories and have a radiation protection service as well. A new aspect of this pilot study is the fact that the irradiations also take place in front of a phantom. Irradiations took place in July and August 1980. The results of 4 institutes show that the personal dosemeters are quite capable of measuring the backscattered photon components

Study Strategies

DEFF Research Database (Denmark)

Nielsen, Camilla Kirketerp; Noer, Vibeke Røn

and theory forms the basis of the research. Veterinary students have been followed through alternating learning contexts referring to both the scholastic academic classrooms and workplaces in commercial pig herds as well as to group work and game-based situations in a mandatory master course - ”the pig...... as a student´ and the process of professionalization. By maintaining the position of focusing upon the education as a situated and formative trajectory, the comparative analysis shows how students in profession-oriented educational settings manage the challenges of education and use study strategies......ID: 1277 / 22 SES 06 B: 2 22. Research in Higher Education Format of Presentation: Paper Alternative EERA Network: 19. Ethnography Topics: NW 22: Teaching, learning and assessment in higher education Keywords: Profession-oriented learning, study strategies, professionalisation processes...

18 CFR 5.11 - Potential Applicant's proposed study plan and study plan meetings.

Science.gov (United States)

2010-04-01

... study: (1) A detailed description of the study and the methodology to be used; (2) A schedule for... each study proposal and the information to be obtained; (2) Address any known resource management goals...; (4) Explain any nexus between project operations and effects (direct, indirect, and/or cumulative) on...

INTRODUCTION/ BACKGROUND OF STUDY

African Journals Online (AJOL)

user

The study was carried out in Abia State. Five out ... study area and the farmers were more of women. ... Cassava utilization, as livestock feed, is very popular in the whole world, ... In order to relieve farmers from this problem of poor yield during harvesting, the .... Also majority (54.7 percent) of the cassava farmers in the study.

STUDYING ON THE INTERNET

Institute of Scientific and Technical Information of China (English)

无

2012-01-01

正Nowadays the Internet is more and more popular.I think it is a good way of learning. First,the Intemet enables people to study whenever and wherever it is convenient. They can also choose to study whatever they are interested in.However,a traditional school doesn't provide such great freedom.Students have to study given sub-

Genre theory in information studies

CERN Document Server

Andersen, Jack

2015-01-01

This book highlights the important role genre theory plays within information studies. It illustrates how modern genre studies inform and enrich the study of information, and conversely how the study of information makes its own independent contributions to the study of genre.

World Biofuels Study

Energy Technology Data Exchange (ETDEWEB)

Alfstad,T.

2008-10-01

This report forms part of a project entitled 'World Biofuels Study'. The objective is to study world biofuel markets and to examine the possible contribution that biofuel imports could make to help meet the Renewable Fuel Standard (RFS) of the Energy Independence and Security Act of 2007 (EISA). The study was sponsored by the Biomass Program of the Assistant Secretary for Energy Efficiency and Renewable Energy (EERE), U.S. Department of Energy. It is a collaborative effort among the Office of Policy and International Affairs (PI), Department of Energy and Oak Ridge National Laboratory (ORNL), National Renewable Energy Laboratory (NREL) and Brookhaven National Laboratory (BNL). The project consisted of three main components: (1) Assessment of the resource potential for biofuel feedstocks such as sugarcane, grains, soybean, palm oil and lignocellulosic crops and development of supply curves (ORNL). (2) Assessment of the cost and performance of biofuel production technologies (NREL). (3) Scenario-based analysis of world biofuel markets using the ETP global energy model with data developed in the first parts of the study (BNL). This report covers the modeling and analysis part of the project conducted by BNL in cooperation with PI. The Energy Technology Perspectives (ETP) energy system model was used as the analytical tool for this study. ETP is a 15 region global model designed using the MARKAL framework. MARKAL-based models are partial equilibrium models that incorporate a description of the physical energy system and provide a bottom-up approach to study the entire energy system. ETP was updated for this study with biomass resource data and biofuel production technology cost and performance data developed by ORNL and NREL under Tasks 1 and 2 of this project. Many countries around the world are embarking on ambitious biofuel policies through renewable fuel standards and economic incentives. As a result, the global biofuel demand is expected to grow very

Innovation and Entrepreneurship Studies

DEFF Research Database (Denmark)

Landström, Hans; Åström, Fredrik; Harirchi, Gouya

2015-01-01

-of-the-art” books in entrepreneurship studies and eleven books in innovation studies. The chapters in these “state-of-the-art” books are written by experts within the field, and it can be assumed that the most frequently cited references in these chapters represent “core knowledge” in entrepreneurship...... innovation and entrepreneurship studies can be considered as two fields or parts of a single broader scientific field, sharing and contributing to the same knowledge base? The studies by Fagerberg et al. and Landström et al. are based on two unique databases consisting of all references in twelve “state...

Project management case studies

CERN Document Server

Kerzner, Harold R

2013-01-01

A new edition of the most popular book of project management case studies, expanded to include more than 100 cases plus a ""super case"" on the Iridium Project Case studies are an important part of project management education and training. This Fourth Edition of Harold Kerzner''s Project Management Case Studies features a number of new cases covering value measurement in project management. Also included is the well-received ""super case,"" which covers all aspects of project management and may be used as a capstone for a course. This new edition:Contains 100-plus case studies drawn from re

NASA Earth Science Mission Control Center Enterprise Emerging Technology Study Study (MCC Technology Study)

Science.gov (United States)

Smith, Dan; Horan, Stephen; Royer, Don; Sullivan, Don; Moe, Karen

2015-01-01

This paper reports on the results of the study to identify technologies that could have a significant impact on Earth Science mission operations when looking out at the 5-15 year horizon (through 2025). The potential benefits of the new technologies will be discussed, as well as recommendations for early research and development, prototyping, or analysis for these technologies.

Actuarial Studies

Data.gov (United States)

U.S. Department of Health & Human Services — The Office of the Actuary in the Centers for Medicare and Medicaid Services (CMS) from time to time conducts studies on various aspects of the Medicare and Medicaid...

Effective Physics Study Habits

Science.gov (United States)

Zettili, Nouredine

2011-04-01

We discuss the methods of efficient study habits and how they can be used by students to help them improve learning physics. In particular, we deal with ideas pertaining to the most effective techniques needed to help students improve their physics study skills. These ideas were developed as part of Project IMPACTSEED (IMproving Physics And Chemistry Teaching in SEcondary Education), an outreach grant funded by the Alabama Commission on Higher Education. This project is motivated by a major pressing local need: A large number of high school physics teachers teach out of field. In the presentation, focus on topics such as the skills of how to develop long term memory, how to improve concentration power, how to take class notes, how to prepare for and take exams, how to study scientific subjects such as physics. We argue that the student who conscientiously uses the methods of efficient study habits will be able to achieve higher results than the student who does not; moreover, a student equipped with the proper study skills will spend much less time to learn a subject than a student who has no good study habits. The underlying issue here is not the quantity of time allocated to the study efforts by the student, but the efficiency and quality of actions. This work is supported by the Alabama Commission on Higher Education as part of IMPACTSEED grant.

Tanzania country study

Energy Technology Data Exchange (ETDEWEB)

Meena, H E [Centre for Energy, Environment, Science and Technology, Dar es Salaam (Tanzania, United Republic of)

1998-10-01

An objective of this study is to analyse the role of the land use sectors of Tanzania (especially forestry) on mitigation of greenhouse gases. Specific emphasis is placed on the relationship between forestry and energy supply from biomass. This is a follow up study on an earlier effort which worked on mitigation options in the country without an in-depth analysis of the forestry and land use sectors. (au)

Zambia country study

Energy Technology Data Exchange (ETDEWEB)

1999-09-01

The Zambia Country Study, which was part of the Danida-funded project Climate Change Mitigation in Southern Africa: Phase 2, aimed at methodological development, national mitigation analysis and institutional capacity building in Zambia. The study comprised the following five elements: Comprehensive evaluation of national social and economic development framework for climate change; Baseline scenario(s) projection(s); Mitigation scenario(s) projection(s); Macro-economic assessment; Implementation Issues. (au) 17 refs.

Tanzania country study

International Nuclear Information System (INIS)

Meena, H.E.

1998-01-01

An objective of this study is to analyse the role of the land use sectors of Tanzania (especially forestry) on mitigation of greenhouse gases. Specific emphasis is placed on the relationship between forestry and energy supply from biomass. This is a follow up study on an earlier effort which worked on mitigation options in the country without an in-depth analysis of the forestry and land use sectors. (au)

Theoretical study of laser feedback interferometry for dynamical material's behaviour studies

International Nuclear Information System (INIS)

Le-Barbier, Laura

2017-01-01

The purpose of this thesis is to study the feasibility of optical feedback interferometry (OFI) for measuring velocities for dynamical material's behaviour studies. Dynamical material's behaviour studies permit to analyse the shocked material when subjects to shocks (laser shocks, isentropic compression, projectiles, etc.). In these conditions, we seek to measure velocities up to 10 km/s. The OFI technique is regularly used as an embedded system to measure slow velocities in various fields. However, very few studies have been performed for determining velocities measurement limits for this system. As a matter of fact, the optical feedback induces nonlinear effects into the laser's cavity: it disrupts the laser's emitted optical power. Depending on the optical feedback strength, the laser can show chaotic behaviour, then it is no longer possible to get the information for the target's velocity or displacement regarding the signal. In this study, we have been developing mathematical models and performing a wide range of numerical simulations to study the performances and the limits of the OFI technique. We have been also studying the influence of the targets reflectivity, the length and the modulation frequency of the external cavity. (author) [fr

An Observational Study of Score Study Practices among Undergraduate Instrumental Music Education Majors

Science.gov (United States)

Silvey, Brian A.; Montemayor, Mark; Baumgartner, Christopher M.

2017-01-01

The purpose of this study was to investigate undergraduate instrumental music education majors' score study practices as they related to the effectiveness of their simulated conducting. Participants (N = 30) were video recorded in two sessions in which they completed a 20-min score study session and a simulated conducting performance. In the first…

Intercultural Development: Study Abroad vs. On-Campus Study

Science.gov (United States)

Anderson, Phillip H.; Lawton, Leigh

2011-01-01

As international travel has become more commonplace and as the economies of the world have become more interdependent, both students and faculties are recognizing the importance of increasing students' ability to function effectively in a global community. Study abroad programs are seen by many as an effective means to provide students with the…

INTERHEART STUDY

Indian Academy of Sciences (India)

First page Back Continue Last page Overview Graphics. INTERHEART STUDY. About 90% of CHD Risk (“PAR”) can be explained by 9 Risk Factors: Smoking. Dyslipidemia. High BP. Diabetes. Abdominal Obesity. Psychosocial Factors. Fruits & Vegetables. Exercise. Alcohol.

What is game studies anyway?

NARCIS (Netherlands)

Nieborg, D.B.; Hermes, J.

2008-01-01

In this introduction, game studies is argued to be a force of innovation for cultural studies. While game studies, as it has developed over the last 10 years, fits well within cultural studies' methodology and theory, it does more than benefit from cultural studies as a 'mother discipline'. Game

UNEP greenhouse gas abatement costing studies. Zimbabwe country study. Phase 1

Energy Technology Data Exchange (ETDEWEB)

Shakespeare Maya, R. [Southern Centre for Energy and Environment (Zimbabwe); Muguti, E. [Ministry of Transport and Energy. Department of Energy (Zimbabwe); Fenhann, J.; Morthorst, P.E. [Risoe National Laboratory. Systems Analysis Department (Denmark)

1992-08-01

The UNEP (United Nations Environment Programme) programme of Greenhouse Gas Abatement Costing Studies is intended to clarify the economic issues involved in assessing the costs of limiting emissions of greenhouse gases and to propose approaches to comparable costing studies. Phase 1 of the Zimbabwe country study describes the current energy situation in Zimbabwe related to the national economy, energy supply and demand and amounts of greenhouse gas emissions. Factors regarding the geography, (including a map illustrating the degree and character of land degradation by erosion) population, politics, international relations, land-use and management of the energy sector are dealt with in detail and the text is illustrated with data compiled from the study. It is estimated that Zimbabwe consumed 270.4 Tj of energy during 1988 and emitted 21.7 tonnes of carbon dioxide. An emission intensity of 80.2 tonnes/Tj for the whole economy and 63.6 tonnes/Tj for electric power generation alone was calculated. Forecasting for the year 2020 estimated carbon dioxide emission intensities of 73.5 tonnes/Tj for the whole economy and 43.7 tonnes for power generation. Net carbon dioxide emissions are predicted to be 30-42 tonnes during 2020. (AB).

R and D Requirements, RF Gun Mode Studies, FEL-2 Steady-State Studies, Preliminary FEL-1 Time-Dependent Studies, and Preliminary Layout Option Investigation

International Nuclear Information System (INIS)

Byrd, John; Corlett, John; Doolittle, Larry; Fawley, William; Lidia, Steven; Penn, Gregory; Ratti, Alex; Staples, John; Wilcox Russell; Wurtele, Jonathan; Zholents, Alexander

2005-01-01

This report constitutes the third deliverable of LBNLs contracted role in the FERMI (at) Elettra Technical Optimization study. It describes proposed RandD activities for the baseline design of the Technical Optimization Study, initial studies of the RF gun mode-coupling and potential effects on beam dynamics, steady-state studies of FEL-2 performance to 10 nm, preliminary studies of time-dependent FEL-1 performance using electron bunch distribution from the start-to-end studies, and a preliminary investigation of a configuration with FEL sinclined at a small angle from the line of the linac

Film studies the basics

CERN Document Server

Villarejo, Amy

2013-01-01

Film Studies: The Basics　is a compelling guide to the study of cinema in all its forms. This second edition has been thoroughly revised and updated to take account of recent scholarship, the latest developments in the industry and the explosive impact of new technologies. Core topics covered include: 　 The history, technology and art of cinema Theories of stardom, genre and film-making The movie industry from Hollywood to Bollywood Who does what on a film set 　 Complete with film stills, end-of-chapter summaries and a substantial glossary,　Film Studies: The Basics　is the ideal introduction to those new to the study of cinema.

Qingdao Port Cardiovascular Health Study: a prospective cohort study.

Science.gov (United States)

Spatz, Erica S; Jiang, Xianyan; Lu, Jiapeng; Masoudi, Frederick A; Spertus, John A; Wang, Yongfei; Li, Xi; Downing, Nicholas S; Nasir, Khurram; Du, Xue; Li, Jing; Krumholz, Harlan M; Liu, Xiancheng; Jiang, Lixin

2015-12-09

In China, efforts are underway to respond to rapidly increasing rates of heart disease and stroke. Yet the epidemiology of cardiovascular disease in China may be different from that of other populations. Thus, there is a critical need for population-based studies that provide insight into the risk factors, incidence and outcomes of cardiovascular disease in China. The Qingdao Port Cardiovascular Health Study is designed to investigate the burden of cardiovascular disease and the sociodemographic, biological, environmental and clinical risk factors associated with disease onset and outcomes. For this study, from 2000 through 2013, 32,404 employees aged 18 years or older were recruited from the Qingdao Port Group in China, contributing 221,923 annual health assessments. The mean age at recruitment was 43.4 (SD=12.9); 79% were male. In this ongoing study, annual health assessments, governed by extensive quality control mechanisms, include a questionnaire (capturing demographic and employment information, medical history, medication use, health behaviours and health outcomes), physical examination, ECG, and blood and urine analysis. Additional non-annual assessments include an X-ray, echocardiogram and carotid ultrasound; bio-samples will be collected for future genetic and proteomic analyses. Cardiovascular outcomes are accessed via self-report and are actively being verified with medical insurance claims; efforts are underway to adjudicate outcomes with hospital medical records. Early findings reveal a significant increase in cardiovascular risk factors from 2000 to 2010 (hypertension: 26.4-39.4%; diabetes: 3.3-8.9%; hyperlipidaemia: 5.0-33.6%; body mass index >28 m/kg(2): 14.1-18.6%). We aim to generate novel insights about the epidemiology and outcomes of cardiovascular disease in China, with specific emphasis on the potentially unique risk factor profiles of this Chinese population. Knowledge generated will be disseminated in the peer-reviewed literature, and will

Qingdao Port Cardiovascular Health Study: a prospective cohort study

Science.gov (United States)

Spatz, Erica S; Jiang, Xianyan; Lu, Jiapeng; Masoudi, Frederick A; Spertus, John A; Wang, Yongfei; Li, Xi; Downing, Nicholas S; Nasir, Khurram; Du, Xue; Li, Jing; Krumholz, Harlan M; Liu, Xiancheng; Jiang, Lixin

2015-01-01

Purpose In China, efforts are underway to respond to rapidly increasing rates of heart disease and stroke. Yet the epidemiology of cardiovascular disease in China may be different from that of other populations. Thus, there is a critical need for population-based studies that provide insight into the risk factors, incidence and outcomes of cardiovascular disease in China. The Qingdao Port Cardiovascular Health Study is designed to investigate the burden of cardiovascular disease and the sociodemographic, biological, environmental and clinical risk factors associated with disease onset and outcomes. Participants For this study, from 2000 through 2013, 32 404 employees aged 18 years or older were recruited from the Qingdao Port Group in China, contributing 221 923 annual health assessments. The mean age at recruitment was 43.4 (SD=12.9); 79% were male. In this ongoing study, annual health assessments, governed by extensive quality control mechanisms, include a questionnaire (capturing demographic and employment information, medical history, medication use, health behaviours and health outcomes), physical examination, ECG, and blood and urine analysis. Additional non-annual assessments include an X-ray, echocardiogram and carotid ultrasound; bio-samples will be collected for future genetic and proteomic analyses. Cardiovascular outcomes are accessed via self-report and are actively being verified with medical insurance claims; efforts are underway to adjudicate outcomes with hospital medical records. Findings to date Early findings reveal a significant increase in cardiovascular risk factors from 2000 to 2010 (hypertension: 26.4–39.4%; diabetes: 3.3–8.9%; hyperlipidaemia: 5.0–33.6%; body mass index >28 m/kg2: 14.1–18.6%). Future Plans We aim to generate novel insights about the epidemiology and outcomes of cardiovascular disease in China, with specific emphasis on the potentially unique risk factor profiles of this Chinese population. Knowledge

Nuclear Industry Family Study

International Nuclear Information System (INIS)

1993-01-01

This is a copy of the U.K.A.E.A. Question and Answer brief concerning an epidemiological study entitled the Nuclear Industry Family Study, to investigate the health of children of AEA, AWE, and BNFL Workers. The study is being carried out by an independent team of medical research workers from the London School of Hygiene and Tropical Medicine, and the Imperial Cancer Research Fund. (UK)

Hydrogeological study

International Nuclear Information System (INIS)

Massa, E.; Carrion, R.

1987-01-01

This work refers to the hydrogeological study about underground water to domestic uses. It was required by Artigas intendence of Uruguay, in the rural school 10, located belongs to the Chiflero zone around the capital of the Artigas Province.

Study Drugs

Science.gov (United States)

... to quit, they may have withdrawal symptoms like depression, thoughts of suicide, intense drug cravings, sleep problems, and fatigue. The health risks aren't the only downside to study drugs. Students caught with illegal prescription drugs may get suspended ...

Vitrification melter study

International Nuclear Information System (INIS)

Jones, J.A.

1995-04-01

This report presents the results of a study performed to identify the most promising vitrification melter technologies that the Department of Energy (EM-50) might pursue with available funding. The primary focus was on plasma arc systems and graphite arc melters. The study was also intended to assist EM-50 in evaluating competing technologies, formulating effective technology strategy, developing focused technology development projects, and directing the work of contractors involved in vitrification melter development

Environmental impact study. 'Cyclical approach case study VEGA'

International Nuclear Information System (INIS)

Setzman, E.; Braennstroem-Norberg, B.M.; Rosen-Lidholm, S.

1993-06-01

The aim of this study has been to identify, describe and assess the environmental factors in the fuel chain which may be of significance for the possibilities of establishing biofuel-fired plants for the production of electricity and heat. The description is based on the documentation for the planned combined heat and power plant in Eskilstuna which will utilize pressurized gasification of biofuel in a combined cycle (VEGA). The study shows that the emissions from the plant are limited and do not give rise to any identifiable environmental effects. The emissions of nitrogen oxides from transportation and from fuel production are equivalent to those from combustion. The environmental consequences of a biofuel-fired plant of this size will be primarily local. The regional effects will be limited and of little significance providing that fuel extraction is not carried out in sensitive areas, transportation by road over long distances is minimized, and the removal of important nutrients through the extraction of biofuels is compensated for, for example by returning ash to the soil. 26 refs, 29 figs, 38 tabs

The Advanced Glaucoma Intervention Study (AGIS): 1. Study design and methods and baseline characteristics of study patients.

Science.gov (United States)

Ederer, F; Gaasterland, D E; Sullivan, E K

1994-08-01

Medical therapy has been the standard initial treatment for open-angle glaucoma. When some visual field has been lost and maximum tolerated and effective medical therapy does not succeed in controlling the disease, the patient is considered to have advanced glaucoma, and the first of a potential sequence of surgical treatments is usually indicated. Little is known about the long-term course and prognosis of advanced glaucoma or about the long-term effectiveness of sequential surgical treatments in controlling the disease and preventing vision loss and blindness. The Advanced Glaucoma Intervention Study was designed to study, in advanced glaucoma, the long-term clinical course and prognosis, and, in a randomized trial, the comparative outcomes of two sequences of surgical treatments. Toward these goals, 789 eyes in 591 patients were enrolled at 11 clinical centers between 1988 and 1992. Follow-up will continue until 1996. Eyes were randomly assigned to one of two sequences of surgical treatments. One sequence begins with argon laser trabeculoplasty (ALT), is followed by trabeculectomy, an incisional surgical filtering procedure, should ALT fail to control the disease, and by a second trabeculectomy should the first trabeculectomy fail. The other sequence begins with trabeculectomy, is followed by ALT should the trabeculectomy fail, and by a second trabeculectomy should ALT fail. The main outcome of interest is visual function (visual field and visual acuity). Other important outcomes are intraocular pressure, complications of surgery, time to treatment failure, and extent of need for additional medical therapy. We present in this paper the rationale, objectives, design and methods of the study, and the baseline characteristics of study patients and eyes.

How to Study a Matrix

Science.gov (United States)

Jairam, Dharmananda; Kiewra, Kenneth A.; Kauffman, Douglas F.; Zhao, Ruomeng

2012-01-01

This study investigated how best to study a matrix. Fifty-three participants studied a matrix topically (1 column at a time), categorically (1 row at a time), or in a unified way (all at once). Results revealed that categorical and unified study produced higher: (a) performance on relationship and fact tests, (b) study material satisfaction, and…

Sistem Pre Kompilasi Data Tracer Studi Online Ditjen Belmawa Ristekdikti (Studi Kasus: Politeknik Harapan Bersama

Directory of Open Access Journals (Sweden)

Very Kurnia Bakti

2017-01-01

Full Text Available Tracer studi merupakan salah satu upaya yang diharapkan dapat menyediakan informasi untuk mengevaluasi hasil pendidikan di Politeknik Harapan Bersama dari kuisioner yang diberikan kepada alumni. Kegiatan tracer studi ini sudah dilaksanakan secara online, namun masih terdapat kendala pada bagian sistem yang digunakan saat ini, hal tersebut menyebabkan Politeknik Harapan Bersama tidak dapat melaporkan / mengunggah hasil tracer studi kepada Ditjen Belmawa Ristekdikti, dimana form kuisioner dan data export tracer studi yang dihasilkan berbeda dengan kebutuhan seperti yang tercantum pada surat edaran No. 313/B/SE/2016 tentang pelaksanaan tracer studi di tingkat perguruan tinggi. Mengingat pentingnya tracer studi sebagai umpan balik bagi Politeknik Harapan Bersama, maka perlu solusi untuk mengatasi kekurangan sistem ini. Dengan merubah sistem yang ada dengan sistem tracer studi yang baru merupakan solusi yang tepat dalam permasalahan ini. Sistem tracer studi yang baru mampu menghasilkan data tracer studi alumni dan pengisian form kuisioner sesuai dengan standar Ditjen Belmawa Ristekdikti yang dapat diunggah sistem tracer studi ristekdikti.

Hanford groundwater scenario studies

International Nuclear Information System (INIS)

Arnett, R.C.; Gephart, R.E.; Deju, R.A.; Cole, C.R.; Ahlstrom, S.W.

1977-05-01

This report documents the results of two Hanford groundwater scenario studies. The first study examines the hydrologic impact of increased groundwater recharge resulting from agricultural development in the Cold Creek Valley located west of the Hanford Reservation. The second study involves recovering liquid radioactive waste which has leaked into the groundwater flow system from a hypothetical buried tank containing high-level radioactive waste. The predictive and control capacity of the onsite Hanford modeling technology is used to evaluate both scenarios. The results of the first study indicate that Cold Creek Valley irrigationis unlikely to cause significant changes in the water table underlying the high-level waste areas or in the movement of radionuclides already in the groundwater. The hypothetical tank leak study showed that an active response (in this case waste recovery) can be modeled and is a possible alternative to passive monitoring of radionuclide movement in the unlikely event that high-level waste is introduced into the groundwater

The bismuth miners study

International Nuclear Information System (INIS)

Grosche, B.; Kreuzer, M.; Kreisheimer, M.; Schnelzer, M.; Tschense, A.; Gottschalk, K.

2005-01-01

The Federal Radiation Protection Office carried out a retrospective cohort study on some 60,000 former employees of the SAG/SDAG Wismut. The purpose of the study was to validate the radon-related risk of acquiring lung cancer previously calculated from 11 jointly evaluated studies among miners on the basis of an independent, homogeneous data record of comparable size. A further goal was to study the risk of acquiring extrapulmonal tumours. This paper only briefly describes the sampling, design and methods used in the study, as these were already presented during the Radon Status Talks. The first follow-up on the cohort was completed in 2003. Around this time a job exposure matrix (JEM) suitable for scientific inquiries was made available by the professional miners' association and the roof organisation of professional trade associations (HVBG). This paper is the first to report on the outcome of the risk analysis in direct comparison with the results found by BEIR

Standards for Certification/Preparation of Social Studies Teachers: A Fifty State Study.

Science.gov (United States)

Dumas, Wayne; Weible, Tom

A national survey determined minimum certification requirements for secondary social studies teachers in general education, professional education, and history/social science. Data were obtained through questionnaires completed by social studies education curriculum specialists and by officials in the certification divisions of state education…

Citizenship as individual responsibility through personal investment - an ethnographic study in a study circle

Directory of Open Access Journals (Sweden)

Annika Pastuhov

2017-05-01

Full Text Available The aim of this article is to shed light on how the democratic ideal of institutionalised Nordic popular education is realised through an ethnographic field study in an English as a foreign language study circle. The study focuses on how participants express their citizenship when taking part in the study circle. Citizenship is viewed as a dynamic concept comprising the aspects of 'being' and 'acting' and constructed in and through social interaction. The study circle is arranged as a classroom practice: The study circle leader organises the activities, while the participants engage in exercises and attempt to learn correct usage. Through their participation, the participants take individual responsibility for what they see as their lack of sufficient knowledge of English. The participants describe their participation as a personal and voluntary investment in themselves. In light of the study, the individual stance is discussed as limiting possibilities for responsibility and thus expressions of citizenship.

Oxidizer Scoping Studies

Energy Technology Data Exchange (ETDEWEB)

Chancellor, Christopher John [Los Alamos National Laboratory

2016-11-07

The purpose of this report is to present the results of the acceptable knowledge (AK) review of oxidizers present in active waste streams, provide a technical analysis of the oxidizers, and report the results of the scoping study testing. This report will determine the fastest burning oxidizer to be used in the development of a Test Plan for Preparation and Testing of Sorbents Mixed with Oxidizer found in Transuranic Waste (DWT-TP-001). The companion report, DWT-RPT-002, Sorbent Scoping Studies, contains similar information for sorbents identified during the AK review of TRU waste streams. The results of the oxidizer and sorbent scoping studies will be used to inform the QL1 test plan. The QL1 test results will support the development of a basis of knowledge document that will evaluate oxidizing chemicals and sorbents in TRU waste and provide guidance for treatment.

Immunology studies

International Nuclear Information System (INIS)

Smith, D.M.; Baron, P.A.; Drake, G.A.; LaBauve, P.M.; London, J.E.; Wilson, J.S.

1977-01-01

The following studies were conducted in the field of immunology; a model system to determine toxic effects on the immune system using 3 H-uridine uptake by Feells of rats; and survival in lethally irradiatd mice receiving allogenic fetal liver and thymus

Networked Microgrids Scoping Study

Energy Technology Data Exchange (ETDEWEB)

Backhaus, Scott N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dobriansky, Larisa [General MicroGrids, San Diego, CA (United States); Glover, Steve [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Liu, Chen-Ching [Washington State Univ., Pullman, WA (United States); Looney, Patrick [Brookhaven National Lab. (BNL), Upton, NY (United States); Mashayekh, Salman [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Pratt, Annabelle [National Renewable Energy Lab. (NREL), Golden, CO (United States); Schneider, Kevin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stadler, Michael [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Starke, Michael [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wang, Jianhui [Argonne National Lab. (ANL), Argonne, IL (United States); Yue, Meng [Brookhaven National Lab. (BNL), Upton, NY (United States)

2016-12-05

Much like individual microgrids, the range of opportunities and potential architectures of networked microgrids is very diverse. The goals of this scoping study are to provide an early assessment of research and development needs by examining the benefits of, risks created by, and risks to networked microgrids. At this time there are very few, if any, examples of deployed microgrid networks. In addition, there are very few tools to simulate or otherwise analyze the behavior of networked microgrids. In this setting, it is very difficult to evaluate networked microgrids systematically or quantitatively. At this early stage, this study is relying on inputs, estimations, and literature reviews by subject matter experts who are engaged in individual microgrid research and development projects, i.e., the authors of this study The initial step of the study gathered input about the potential opportunities provided by networked microgrids from these subject matter experts. These opportunities were divided between the subject matter experts for further review. Part 2 of this study is comprised of these reviews. Part 1 of this study is a summary of the benefits and risks identified in the reviews in Part 2 and synthesis of the research needs required to enable networked microgrids.

Bank retreat study of a meandering river reach case study : River Irwell

NARCIS (Netherlands)

Duran, R.; Beevers, L.; Crosato, A.; Wright, N.

2010-01-01

Lack of data is often considered a limitation when undertaking morphological studies. This research deals with morphological studies of small rivers experiencing bank erosion processes when only limited data are available. A reach of the meandering gravel-bed river Irwell (United Kingdom) is taken

Solid waste study

International Nuclear Information System (INIS)

Ortiz, Paul G.

1995-01-01

The purpose of this document is to study the solid waste issues brought about by a Type C Investigation; ''Disposal of Inappropriate Material in the Los Alamos County Landfill'' (May 28, 1993). The study was completed in August 1995 by Coleman Research Corporation, under subcontract number 405810005-Y for Los Alamos National Laboratory (LANL). The study confirmed the issues identified in the Type C investigation, and also ascertained further issues or problems. During the course of this study two incidents involving hazardous waste resulted in the inappropriate disposal of the waste. An accidental spill, on June 8, 1995, at one of Laboratory buildings was not handled correctly, and ended up in the LAC Landfill. Hazardous waste was disposed of in a solid waste container and sent to the Los Alamos County Landfill. An attempt to locate the hazardous waste at the LAC Landfill was not successful. The second incident involving hazardous waste was discovered by the FSS-8, during a random dumpster surveillance. An interim dumpster program managed by FSS-8 discovered hazardous waste and copper chips in the solid waste, on August 9, 1995. The hazardous waste and copper chips would have been transported to the LAC Landfill if the audit team had not brought the problem to the awareness of the facility waste management personnel

SOLID WASTE STUDY

Energy Technology Data Exchange (ETDEWEB)

PAUL G. ORTIZ - COLEMAN RESEARCH CORP/COMPA INDUSTRIES

1995-08-01

The purpose of this document is to study the solid waste issues brought about by a Type C Investigation; ``Disposal of Inappropriate Material in the Los Alamos County Landfill'' (May 28, 1993). The study was completed in August 1995 by Coleman Research Corporation, under subcontract number 405810005-Y for Los Alamos National Laboratory (LANL). The study confirmed the issues identified in the Type C investigation, and also ascertained further issues or problems. During the course of this study two incidents involving hazardous waste resulted in the inappropriate disposal of the waste. An accidental spill, on June 8, 1995, at one of Laboratory buildings was not handled correctly, and ended up in the LAC Landfill. Hazardous waste was disposed of in a solid waste container and sent to the Los Alamos County Landfill. An attempt to locate the hazardous waste at the LAC Landfill was not successful. The second incident involving hazardous waste was discovered by the FSS-8, during a random dumpster surveillance. An interim dumpster program managed by FSS-8 discovered hazardous waste and copper chips in the solid waste, on August 9, 1995. The hazardous waste and copper chips would have been transported to the LAC Landfill if the audit team had not brought the problem to the awareness of the facility waste management personnel.

Baccalaureate Student Nurses' Study Habits Prior to Admission to Nursing Program: A Descriptive Qualitative Study.

Science.gov (United States)

Felicilda-Reynaldo, Rhea Faye D; Cruz, Jonas Preposi; Bigley, Louise; Adams, Kathryn

2017-06-01

Faculty continue to observe students struggling as they adapt their study strategies to learn nursing core content. This study described the study habits of Bachelor of Science in Nursing (BSN) students prior to admission to the program. This study used a descriptive qualitative research design. A purposive sample of 19 BSN students (juniors [n=10] and seniors [n=9]) from a 4-year public Midwestern university were included in this study. Two focus group sessions, using a semi-structured interview guide, were conducted in the spring semester of 2013. The four themes which emerged from the analysis of data were: "I just got it," "I had a lot of time then," "I studied alone" mostly, and "…a little struggle with the sciences." The findings suggest the BSN students did not study much or employed poor study strategies during their years completing general education courses. Academic support is needed by students prior to admission to the nursing program so they can learn effective study skills and modify their study habits for easier adaptation to the rigors of nursing education. Published by Elsevier Ltd.

[Studies of biologic activation associated with molecular receptor increase and tumor response in ChL6/L6 protocol patients; Studies in phantoms; Quantitative SPECT; Preclinical studies; and Clinical studies]. DOE annual report, 1994-95

International Nuclear Information System (INIS)

DeNardo, S.J.

1995-01-01

The authors describe results which have not yet been published from their associated studies listed in the title. For the first, they discuss Lym-1 single chain genetically engineered molecules, analysis of molecular genetic coded messages to enhance tumor response, and human dosimetry and therapeutic human use radiopharmaceuticals. Studies in phantoms includes a discussion of planar image quantitation, counts coincidence correction, organ studies, tumor studies, and 90 Y quantitation with Bremsstrahlung imaging. The study on SPECT discusses attenuation correction and scatter correction. Preclinical studies investigated uptake of 90 Y-BrE-3 in mice using autoradiography. Clinical studies discuss image quantitation verses counts from biopsy samples, S factors for radiation dose calculation, 67 Cu imaging studies for lymphoma cancer, and 111 In MoAb imaging studies for breast cancer to predict 90 Y MoAb therapy

522 Postmarket Surveillance Studies

Data.gov (United States)

U.S. Department of Health & Human Services — The 522 Postmarket Surveillance Studies Program encompasses design, tracking, oversight, and review responsibilities for studies mandated under section 522 of the...

DINAMIKA STUDI ISLAM DI BARAT

Directory of Open Access Journals (Sweden)

M Rusydi

2016-04-01

Full Text Available The following writing shows the historicity of Islamic studies in the West. It is important to reflect, at least as a comparison for our Islamic studies in Indonesia. Initially, Islamic studies in the West were looked unfairly. Islam was considered a fragment of Jews and Christian tradition. Thus, Islamic studies were positioned as a subunit of Christian studies. At this condition, Islamic studies tended to be colonized by West scholars’ ideology. However, in 1980, Islamic studies began to be looked fairly in the West. Funded by National Endowment for the Humanities, University of Arizona for the first time held an international symposium on Islam and Religious Studies. In this symposium, Islam was considered equally with Christian. Therefore, the research on it was not only about Islam as religion but also as civilization. It was indicated by various approaches to Islam such as philology, social and humanities approaches. Today, Islamic studies develop intensively with the contemporary approaches called post-orientalism which is based on post-colonialism, post-structuralism, multiculturalism, and critical theory.

Case-control studies in neurosurgery.

Science.gov (United States)

Nesvick, Cody L; Thompson, Clinton J; Boop, Frederick A; Klimo, Paul

2014-08-01

Observational studies, such as cohort and case-control studies, are valuable instruments in evidence-based medicine. Case-control studies, in particular, are becoming increasingly popular in the neurosurgical literature due to their low cost and relative ease of execution; however, no one has yet systematically assessed these types of studies for quality in methodology and reporting. The authors performed a literature search using PubMed/MEDLINE to identify all studies that explicitly identified themselves as "case-control" and were published in the JNS Publishing Group journals (Journal of Neurosurgery, Journal of Neurosurgery: Pediatrics, Journal of Neurosurgery: Spine, and Neurosurgical Focus) or Neurosurgery. Each paper was evaluated for 22 descriptive variables and then categorized as having either met or missed the basic definition of a case-control study. All studies that evaluated risk factors for a well-defined outcome were considered true case-control studies. The authors sought to identify key features or phrases that were or were not predictive of a true case-control study. Those papers that satisfied the definition were further evaluated using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. The search detected 67 papers that met the inclusion criteria, of which 32 (48%) represented true case-control studies. The frequency of true case-control studies has not changed with time. Use of odds ratios (ORs) and logistic regression (LR) analysis were strong positive predictors of true case-control studies (for odds ratios, OR 15.33 and 95% CI 4.52-51.97; for logistic regression analysis, OR 8.77 and 95% CI 2.69-28.56). Conversely, negative predictors included focus on a procedure/intervention (OR 0.35, 95% CI 0.13-0.998) and use of the word "outcome" in the Results section (OR 0.23, 95% CI 0.082-0.65). After exclusion of nested case-control studies, the negative correlation between focus on a procedure

Prevalence studies in rheumatology: the methodology of the Chiavari study

Directory of Open Access Journals (Sweden)

T. Maio

2011-09-01

Full Text Available Objectives: Goals of epidemiological studies are the description of the measures of frequency of diseases, the attempt to clarify possible etiopathogenic mechanisms, and the provision of data to support health policy decisions. To increase the familiarity of rheumatologists toward epidemiology, we describe the methodology used in a prevalence study of musculoskeletal complaints performed in Chiavari, Italy. Methods: A questionnaire, originally developed by the Epidemiology Unit of the Arthitis Research Council in Manchester, UK, to investigate the prevalence of rheumatoid arthritis, was used after translation and validation. 4456 subjects aged 16 years or more listed in four general practices were invited to participate in the study and to fill the ARC questionnaire. The 3294 responders reported a any past occurrence of joint swelling lasting more than four weeks and the distribution of the swollen joints on a mannequin; b any joint pain lasting more than four weeks; c current joint pain or swelling; d morning stiffness; e whether they had been previously told by a doctor they had arthritis. Results: Four steps were necessary to obtain a 74% response, i.e. direct contact, two mailings and a phone interview. The performance of the different questions was good. The prevalence of the most common conditions among patients answering positively to the questions regarding morning stiffness and symmetrical swelling of joints was as follows: osteoarthritis 2.60%, fibromyalgia 1.30%, carpal tunnel syndrome 1.14%, rheumatoid arthritis 0.31%, and psoriatic arthritis 0.10%. Conclusions: Methodological issues regarding the selection of the population and sample to study, the development of a questionnaire, and the problems in obtaining valid informations are discussed.

A longitudinal study

OpenAIRE

Kristen, Astrid

2010-01-01

Does playing violent video games increase aggressive behavior over time or is it aggressive children who increasingly seek out (and play) these violent video games? To study such long-term effects a longitudinal design is necessary. Within a field study in a large German city (Kinder, Computer, Hobby, Lernen – KUHL, Freie Universtität Berlin) about 115 elementary school boys attending in the beginning (t1) classrooms of the third and fourth grade and twelve months later (t2) classrooms of the...

STARFIRE-II studies. Summary

International Nuclear Information System (INIS)

Baker, C.C.; Brooks, J.N.; Ehst, D.A.; Smith, D.L.; Sze, D.K.

1985-01-01

The US Department of Energy's Office of Fusion Energy has initiated several studies during FY-1985 called Tokamak Power System Studies (TPSS). The TPSS is being carried out by several laboratories, universities and industry with the general objective of developing innovative physics and technology concepts to improve the commercial attractiveness of tokamak power reactors. The effort of Argonne National Laboratory, entitled STARFIRE-II, is an effort to update and improve STARFIRE, which was the last comprehensive conceptual design study in the US of a commercial tokamak power plant. The STARFIRE-II effort has developed a number of goals in order to improve fusion commercial power plants based in part on several recent studies. The primary goals for STARFIRE-II are listed

Penerapan Metode Profile Matching Pada Sistem Pendukung Keputusan Pemilihan Ketua Program Studi (STUDI Kasus : Program Studi Teknik Informatika STMIK Musi Rawas

Directory of Open Access Journals (Sweden)

Andri Anto Tri Susilo

2018-01-01

Full Text Available Abstract-- In the organizational structure of a study program, always led by a chairman of the study program. In STMIK Musi Rawas, the process of selecting the head of the study program is usually appointed directly by the chairman of the foundation. The shortcomings of the direct appointment process is not able to see the capabilities possessed by the candidate chairman of the study program be it social skills, planning, management of learning, management of Human Resources, Finance and so forth. Decision support system is a system that can be used to help make decisions based on existing criteria. In this research the method used is Profile Matching method. The concept of Profile Matching method is to compare individual competence into job competence so that it can know the difference of competence (also called gap, the smaller the gap that is generated, the greater the value the greater the greater the chance for someone to occupy the position. The end result of this research is obtained information about the highest value of each candidate chairman of the Study Program based on the calculation of Profile Matching

Studying and Working: A National Study of Student Finances and Student Engagement

Science.gov (United States)

Devlin, Marcia; James, Richard; Grigg, Gabrielle

2008-01-01

A key determinant of the new relationship between students and universities in Australia is the changing nature of higher education funding arrangements and the shift towards "user-pays". In 2007, the Centre for the Study of Higher Education (CSHE) completed a commissioned national study, "Australian University Student Finances…

Waarom Jesus-studies?

Directory of Open Access Journals (Sweden)

P. A. Geyser

2000-12-01

Full Text Available Why Jesus studies? Present-day historical Jesus studies are the epistemological product of what has become known as the New Historicism. The aim of the article is to emphasize two aspects of the New Historicism as epistemological approach. The one aspect focuses on the profitability of this endeavour and the other on the historical nature of the New Historicism. As far as profitability is concerned, the social standing and identity of the researcher are emphasized. Among otherthings, the social interests of the researcher are taken into account. Concerning the historical nature of this kind of research, a distinction is drawn between the Jesus of history and the Jesus of faith. The aim of the article is to gain clarity on the relationship between the Jesus of history (pre-Easter and the Jesus of faith (post-Easter. J D Crossan's exposition of the reasons for Jesus studies is followed. He distinguishes three reasons: historical, ethical and theological.

Structural issues affecting mixed methods studies in health research: a qualitative study

Science.gov (United States)

2009-01-01

Background Health researchers undertake studies which combine qualitative and quantitative methods. Little attention has been paid to the structural issues affecting this mixed methods approach. We explored the facilitators and barriers to undertaking mixed methods studies in health research. Methods Face-to-face semi-structured interviews with 20 researchers experienced in mixed methods research in health in the United Kingdom. Results Structural facilitators for undertaking mixed methods studies included a perception that funding bodies promoted this approach, and the multidisciplinary constituency of some university departments. Structural barriers to exploiting the potential of these studies included a lack of education and training in mixed methods research, and a lack of templates for reporting mixed methods articles in peer-reviewed journals. The 'hierarchy of evidence' relating to effectiveness studies in health care research, with the randomised controlled trial as the gold standard, appeared to pervade the health research infrastructure. Thus integration of data and findings from qualitative and quantitative components of mixed methods studies, and dissemination of integrated outputs, tended to occur through serendipity and effort, further highlighting the presence of structural constraints. Researchers are agents who may also support current structures - journal reviewers and editors, and directors of postgraduate training courses - and thus have the ability to improve the structural support for exploiting the potential of mixed methods research. Conclusion The environment for health research in the UK appears to be conducive to mixed methods research but not to exploiting the potential of this approach. Structural change, as well as change in researcher behaviour, will be necessary if researchers are to fully exploit the potential of using mixed methods research. PMID:20003210

Structural issues affecting mixed methods studies in health research: a qualitative study.

Science.gov (United States)

O'Cathain, Alicia; Nicholl, Jon; Murphy, Elizabeth

2009-12-09

Health researchers undertake studies which combine qualitative and quantitative methods. Little attention has been paid to the structural issues affecting this mixed methods approach. We explored the facilitators and barriers to undertaking mixed methods studies in health research. Face-to-face semi-structured interviews with 20 researchers experienced in mixed methods research in health in the United Kingdom. Structural facilitators for undertaking mixed methods studies included a perception that funding bodies promoted this approach, and the multidisciplinary constituency of some university departments. Structural barriers to exploiting the potential of these studies included a lack of education and training in mixed methods research, and a lack of templates for reporting mixed methods articles in peer-reviewed journals. The 'hierarchy of evidence' relating to effectiveness studies in health care research, with the randomised controlled trial as the gold standard, appeared to pervade the health research infrastructure. Thus integration of data and findings from qualitative and quantitative components of mixed methods studies, and dissemination of integrated outputs, tended to occur through serendipity and effort, further highlighting the presence of structural constraints. Researchers are agents who may also support current structures - journal reviewers and editors, and directors of postgraduate training courses - and thus have the ability to improve the structural support for exploiting the potential of mixed methods research. The environment for health research in the UK appears to be conducive to mixed methods research but not to exploiting the potential of this approach. Structural change, as well as change in researcher behaviour, will be necessary if researchers are to fully exploit the potential of using mixed methods research.

Cosmos-1989 immunology studies

Science.gov (United States)

Sonnenfeld, Gerald

1991-01-01

Evidence from both human and rodent studies has indicated that alterations in immunological parameters occur after space flight. The number of flight experiments has been small, and the full breadth of immunological alterations occurring after space flight remains to be established. Among the major effects on immune responses after space flight that have been reported are: alterations in lymphocyte blastogenesis and natural killer cell activity, alterations in production of cytokines, changes in leukocyte sub-population distribution, and decreases in the ability in the ability of bone marrow cells to respond to colony stimulating factors. Changes have been reported in immunological parameters of both humans and rodents. The significance of these alterations in relation to resistance to infection remains to be established. The current study involved a determination of the effects of flight on Cosmos mission 2044 on leukocyte subset distribution and the sensitivity of bone marrow cells to colony stimulating factor-GM. A parallel study with antiorthostatic suspension was also carried out. The study involved repetition and expansion of studies carried out on Cosmos 1887.

Photovoltaics information user study

Energy Technology Data Exchange (ETDEWEB)

Belew, W.W.; Wood, B.L.; Marie, T.L.; Reinhardt, C.L.

1980-10-01

The results of a series of telephone interviews with groups of users of information on photovoltaics (PV) are described. These results, part of a larger study on many different solar technologies, identify types of information each group needed and the best ways to get information to each group. The report is 1 of 10 discussing study results. The overall study provides baseline data about information needs in the solar community. It covers these technological areas: photovoltaics, passive solar heating and cooling, active solar heating and cooling, biomass energy, solar thermal electric power, solar industrial and agricultural process heat, wind energy, ocean energy, and advanced energy storage. An earlier study identified the information user groups in the solar community and the priority (to accelerate solar energy commercialization) of getting information to each group. In the current study only high-priority groups were examined. Results from seven PV groups respondents are analyzed in this report: DOE-Funded Researchers, Non-DOE-Funded Researchers, Researchers Working for Manufacturers, Representatives of Other Manufacturers, Representatives of Utilities, Electric Power Engineers, and Educators.

Are studies of psychotherapies for depression more or less generalizable than studies of antidepressants?

NARCIS (Netherlands)

Lorenzo-Luaces, Lorenzo; Zimmerman, Mark; Cuijpers, Pim

Background: The generalizability of findings from studies exploring the efficacy of psychotherapy and antidepressants has been called into question in part because studies exclude many patients. Despite this, the frequency with which psychotherapy and antidepressant studies use specific inclusion

Chemical Industry Bandwidth Study

Energy Technology Data Exchange (ETDEWEB)

none,

2006-12-01

The Chemical Bandwidth Study provides a snapshot of potentially recoverable energy losses during chemical manufacturing. The advantage of this study is the use of "exergy" analysis as a tool for pinpointing inefficiencies.

International Research and Studies Program

Science.gov (United States)

Office of Postsecondary Education, US Department of Education, 2012

2012-01-01

The International Research and Studies Program supports surveys, studies, and instructional materials development to improve and strengthen instruction in modern foreign languages, area studies, and other international fields. The purpose of the program is to improve and strengthen instruction in modern foreign languages, area studies and other…

Polarization study

International Nuclear Information System (INIS)

Nurushev, S.B.

1989-01-01

Brief review is presented of the high energy polarization study including experimental data and the theoretical descriptions. The mostimportant proposals at the biggest accelerators and the crucial technical developments are also listed which may become a main-line of spin physics. 35 refs.; 10 figs.; 4 tabs

The impact of risk studies

International Nuclear Information System (INIS)

Hansson, B.

The report is a summary of the reports of various subprojects on nuclear safety. The purpose of the study was to evaluate the role and usefulness of major risk studies in societal opinion forming and decision making processes. The primary research material consisted in seven major risk studies, three of which were concerned with radioactive waste handling, two with reactor safety and two with comparative studies of various sources of energy. Special attention was given to the following four aspects: a) the way in which the studies were interpreted b)the extent to which these studies have clarified the risks they analyse c) the extent to which these studies have narrowed the scientific debate d) the degree to which these studies have actually influenced safety measures and regulatory policy. The picture which emerges is one of success in relation to the effects on the nuclear establishment and largely a failure as attempts at settling disputes and informing the public. (G.B.)

Study of wilms' tumor

International Nuclear Information System (INIS)

Khan, M.H.; Yaqub, N.

2001-01-01

This study is an effort to bring into light data related to children with Wilms' tumor managed at Islamabad as local literature on this topic is lacking. It was retrospective study. The study was conducted at Children Hospital, Pakistan Institute of Medical Science, Islamabad between January, 1987 and December 1995. All patients managed during the study period were included in the study. In all the patients complete blood count (CBC), urine analysis (D/R),X-ray abdomen and chest, ultrasound abdomen and in selected cases CT scan were performed. National Wilms' Tumor Study Group (NWTS 3) protocol was followed for further management. Fifty patients including 28 males and 22 females with the age range from 9 months to 8 years were managed in 9 years period. Left kidney was involved in 31 patients. Most of the tumors were solid on ultrasound, 76% patients were in stage III and IV. In one case bilateral involvement of kidney was found. Forty patients underwent primary surgery. Only 14 patients received complete course of chemotherapy while 31 radiotherapy. Nineteen patients died and 15 lost to follow-up. The survival and mortality rates are comparable to NWTS-3 results, although, most of the patients were presented in advance stage of Wilms tumor. The survival of these patients can be improved by increasing awareness of society through electronic and print media. (author)

Postpartum physiology, psychology and paediatric follow up study (P4 Study) - Study protocol.

Science.gov (United States)

Davis, Gregory K; Roberts, Lynne; Mangos, George; Henry, Amanda; Pettit, Franziska; O'Sullivan, Anthony; Homer, Caroline S E; Craig, Maria; Harvey, Samuel B; Brown, Mark A

2016-10-01

Women who have had hypertension in pregnancy are at greater risk of long term cardiovascular disease (CVD). Little is known about their cardiovascular risk postpartum or the effects on the woman's mental health and the outcomes of their infants. In this project we will study the physiological and psychological health of women and the physical health and development of their infants six months, two years and five years after birth. We will establish normal blood pressure (BP) and metabolic function for women who were normotensive in pregnancy and use these to assess women who had gestational hypertension (GH) or preeclampsia (PE). Women will be asked to participate if they have given birth in the preceding six months. They will be excluded if they had diabetes, hypertension, renal or other serious maternal disease prior to pregnancy or congenital anomaly in the pregnancy. We will recruit 292 women who were normotensive and their babies, 100 who had GH and 100 who had PE and their babies. They will be assessed at six months, two and five years after birth. At each assessment mothers will have their blood pressure (BP) assessed peripherally with a liquid crystal sphygmomanometer and 24h ambulatory blood pressure monitoring (ABPM), and centrally with non-invasive applanation tonometry. Additional physiological testing will include: body composition; energy balance; vascular compliance; cardiac function; liver and renal function, lipids and biochemistry; glucose and insulin; and urinalysis. Psychological status will be assessed with validated self-report questionnaires for depression, anxiety, post-traumatic stress disorder (PTSD) and mother-infant bonding. The babies will have a medical examination by a paediatrician at each assessment. Their behavioural development will be assessed with an Ages and Stages Questionnaire completed by their mother at each assessment and a developmental assessment by a child psychologist at two and five years. This study will re

Phase controlled rectifier study

International Nuclear Information System (INIS)

Bronner, G.; Murray, J.G.

1976-03-01

This report introduces the results of an engineering study incorporating a computer program to determine the transient and steady-state voltage and current wave shapes for a 12-pulse rectifier system. Generally, rectifier engineering studies are completed by making simplified assumptions and neglecting many circuit parameters. The studies incorporate the 3-phase AC parameters including nonlinear source or generator, 3-winding transformer impedances, and shunt and series capacitors. It includes firing angle control, and DC filter circuits with inductive loads

FEMA DFIRM Study Info

Data.gov (United States)

Minnesota Department of Natural Resources — This table contains details about the study such as the study name, datum, projection, etc. There is normally only one record in this table for each Flood Insurance...

Kuwait oil spill studied

Science.gov (United States)

Bush, Susan

1992-02-01

More than a year after the Persian Gulf War, scientists are still trying to assess the environmental impact of the estimated 6-8 million barrels of oil that were dumped into the gulf and to understand the environmental processes that take place in such a disturbance. Many atmospheric studies were done in the months immediately following the war, but oceanographic studies have been slower in getting started.The National Oceanic and Atmospheric Administration is currently spearheading a major oceanographic study being undertaken in the Persian Gulf by the research vessel Mt. Mitchell. The ship left its home port of Norfolk, Va., in mid-January and arrived in Muscat, Oman, on February 16 to begin a 100-day oceanographic and environmental survey. The six-leg cruise will feature physical oceanography, near-shore, and marine life studies.

American Women and American Studies.

Science.gov (United States)

Chmaj, Betty E.

The American Studies Association (ASA) is an interprofessional group, representing a cross-section of persons from American literature, American history, the social sciences, philosophy, archeology, Black Studies, Urban Studies, American Studies, and others. This document by the ASA Commission on the Status of Women includes: (1) a report of the…

Comprehensive study on nuclear weapons. Summary of a United Nations study

International Nuclear Information System (INIS)

1991-01-01

In December 1988, by resolution 43/75N, the United Nations General Assembly requested the Secretary-General to carry out a comprehensive update of a 1980 study on nuclear weapons. The study was to take into account recent relevant studies, and consider the political, legal and security aspects of: (a) nuclear arsenals and pertinent technological developments; (b) doctrines concerning nuclear weapons; (c) efforts to reduce nuclear weapons; (d) physical, environmental, medical and other effects of the use of nuclear weapons and of nuclear testing; (e) efforts to achieve a comprehensive nuclear-test ban; (f) efforts to prevent the use of nuclear weapons and their horizontal and vertical proliferation; and (g) the question of verification of compliance with nuclear-arms limitation agreements. The Group's report is presented in nine chapters, eight of which are summarized here; chapter 9, entitled ''Conclusions'', is included in its entirety. In his foreword to the report, the Secretary-General observes that the study represents the most comprehensive review of the relevant developments in the field over the last decade and was carried out during a period of ''far-reaching changes in international relations'' and an ''unprecedented evolution in the relationship between East and West''. This period experienced for the first time the initiation of an effective process of reduction of nuclear weapon stockpiles

Dietary studies of children: the Bogalusa Heart Study experience.

Science.gov (United States)

Nicklas, T A

1995-10-01

For more than 20 years the Bogalusa Heart Study has been collecting data on children's dietary intakes in a biracial community. The macronutrient contribution of children's diets is similar to that in diets of adolescents: 13% of energy from protein, 49% from carbohydrate, and 38% from fat. As children get older, mean intakes of vitamins and minerals per 1,000 kcal decrease. Ten-year-old children in 1987-1988 were 3 lb heavier than 10-year-olds in 1973-1974. Yet total energy intakes remained virtually the same from 1973 to 1988. The composition of macronutrients shifted over the 15-year period, with an increase in the percentage of energy from protein and carbohydrate and a decrease in the percentage of energy from total fat, particularly saturated fat. Dietary cholesterol intake also decreased as a result of a decrease in egg consumption. Although the diets of children changed positively from 1973 to 1988, more than 75% of children consumed more total fat, saturated fat, and cholesterol than the recommended amounts. School meals had a major impact on the diets of children. School breakfast and lunch, together, contributed approximately 50% of the day's total intake of energy, protein, cholesterol, carbohydrate, and sodium. About 40% of daily total fat intake came from school breakfast and lunch. The diets of children in the Bogalusa study are similar to those reported in national studies of children. What might be different, however, are the types of foods consumed and their contribution to intakes of specific nutrients.(ABSTRACT TRUNCATED AT 250 WORDS)

Rethinking of the criteria for natural analogue study. A case of Tono natural analogue study

International Nuclear Information System (INIS)

Yoshida, Hidekazu

1996-01-01

Natural analogue regarding long-term performance of the geological disposal system for radioactive waste isolation is essentially the study of geochemical process which has been evolved in geological environment. All geochemical studies, however, will not be nominated as natural analogue studies. It is, therefore, important to be clear the criteria for natural analogue study with the view of analogy by following three categories, (1) Conceptual model development, (2) Data provision and (3) Model testing, for the concept of geological disposal and safety assessment model. Rethinking of the criteria for natural analogue study through the case of Tono Natural Analogue Study, and the usefulness of natural analogue study for the safety assessment of geological disposal system in Japan have been presented in this paper. (author)

Final report on case studies

DEFF Research Database (Denmark)

Ljungberg, Daniel; McKelvey, Maureen; Lassen, Astrid Heidemann

2012-01-01

Case study as a research design means investigating a single or multiple instance(s) or setting(s) (i.e. a case) and its entire context to explain a phenomenon and its processes. This is achieved through detailed understanding, usually comprised of multiple sources of information. In this way, case...... studies attempt to provide as a complete an understanding of a (complex) phenomenon as possible. Within the AEGIS project, survey and case study research are complementary. They are complementary in the sense that the former can provide more generalizable evidence on a phenomenon in terms of cross......-sectional data, while the latter can provide more in-depth (qualitative) understanding on specific issues. In systematically examining the case studies, however, this report goes beyond a typical single case study. Here we provide a synthesis of 86 case studies. Multiple case studies, following similar focus...

Study of strange nuclei

International Nuclear Information System (INIS)

Chrien, R.E.

1982-01-01

A brief history of the discovery of hypernuclei is given and some recent hypernuclei studies are described. Topics include the study of p-shell hypernuclei, 12 C (K - , π - ) experiment, and hypernuclear gamma rays. 13 references

Study of the Release Process of Open Source Software: Case Study

OpenAIRE

Eide, Tor Erik

2007-01-01

This report presents the results of a case study focusing on the release process of open source projects initiated with commercial motives. The purpose of the study is to gain an increased understanding of the release process, how a community can be attracted to the project, and how the interaction with the community evolves in commercial open source initiatives. Data has been gathered from four distinct sources to form the basis of this thesis. A thorough review of the open source literatu...

Teaching Secondary Social Studies

Directory of Open Access Journals (Sweden)

Colin Everett

2018-03-01

Full Text Available Review of the book, instructional strategies for middle and high school social studies: Methods, assessment, and classroom management, by Bruce E. Larson. The book has two goals: It situates the learning of social studies within the broader developmental context of learning and also focuses on “Instructional Strategies.” “Instructional Strategies for Middle and High School Social Studies: Methods, Assessment, and Classroom Management.” 2nd Edition. By Bruce E. Larson. New York: Routledge, 2017. ISBN: 978-1-138-84678-4

American Studies in Romania

Directory of Open Access Journals (Sweden)

Ioana Luca

2006-01-01

Full Text Available American Studies at the University of BucharestThe idea of teaching American Studies and founding a program in American Studies was first voiced in the long meetings of faculty and students held at the University of Bucharest soon after the collapse of the communist regime. The proposal was one of many that reflected the spirit of reform and hope for radical changes at the outset of Romania’s transition to democracy. The absence of institutional structures other than English departments and t...

How To Set Up Your Own Small Business. Service Company Case Study. Manufacturing Firm Case Study. Retail Store Case Study.

Science.gov (United States)

Fallek, Max

This collection of case studies is intended for use in a course in setting up a small business. The first, a case study of the process of setting up a service company, covers analyzing the pros and cons of starting one's own business, assessing the competition and local market, and selecting a site for and financing the business. The principal…

Regional Studies Program

International Nuclear Information System (INIS)

Parzyck, D.C.

1978-01-01

Progress is reported on methodology studies with regard to hydrologic analysis; atmospheric transport; forest growth models; distribution of sensitive species; agricultural analysis; and environmental objectives in energy facility siting. National coal utilization assessment studies are reported with regard to technology characterization; air quality impacts; water resources; regional characterization; forest impacts; coal extraction impacts on sensitive animal species; and health impacts. The following special projects were carried out: water resource aspects of inexhaustible technology deployment; ecological constraints on the rapidly expanded use of coal; and U.S. coal and the global carbon problem

Rockwell support studies

International Nuclear Information System (INIS)

Rogers, L.E.

1978-01-01

The Rockwell Hanford Operations (RHO) supported ecological studies are designed to clarify ecosystem structure and functioning as pertaining to the management of radioactive waste control areas. To date, emphasis has been placed on characterizing the abiotic and biotic components of these areas, resulting in publication of over 20 PNL documents and several scientific articles pertinent to the 200 Area Waste Management Program. Results are reported from studies on the food habits of ground-dwelling beetles, mule deer, and American Coots inhabiting the areas, and the radiation dose received by rodents inhabiting waste management areas

Throughput rate study

International Nuclear Information System (INIS)

Ford, L.; Bailey, W.; Gottlieb, P.; Emami, F.; Fleming, M.; Robertson, D.

1993-01-01

The Civilian Radioactive Waste Management System (CRWMS) Management and Operating (M ampersand O) Contractor, has completed a study to analyze system wide impacts of operating the CRWMS at varying throughput rates, including the 3000 MTU/year rate which has been assumed in the past. Impacts of throughput rate on all phases of the CRWMS operations (acceptance, transportation, storage and disposal) were evaluated. The results of the study indicate that a range from 3000 to 5000 MTU/year is preferred, based on system cost per MTU of SNF emplaced and logistics constraints

Morphing Terminology Study

Energy Technology Data Exchange (ETDEWEB)

Rose, Stuart J.; Brockman, Fred J.; Hart, Michelle L.; Engel, David W.; Valentine, Nancy B.; Calapristi, Augustin J.

2010-06-28

This study investigates methods of automatically identifying and characterizing significant transitions in term usage over time. Within scientific literature, the occurrence of terms reflects the use of technologies and techniques as well as the study of specific species and materials. Transitions in terminology usage may be a result of vocabulary standardization or specialization in which terms are replaced with their shorter form. They may also be a result of new applications, combinations, alternatives, or interests that result in the appearance of new or existing terminology in unexpected contexts.

Case study - Argentina

International Nuclear Information System (INIS)

Diaz, E.

1986-01-01

Antecedents and experience of nuclear activities in Argentina; the Atomic Energy Commission (CNEA). First development and research activities. Research reactors and radioisotopes plants. Health physics and safety regulations. - Feasibility studies for the first nuclear power plant. Awarding the first plant CNA I (Atucha I). Relevant data related to the different project stages. Plant performance. - Feasibility study for the second nuclear power plant. Awarding the second plant CNE (Central Nuclear Embalse). Relevant data related to established targets. Differences compared with the first station targets. Local participation. Plant performance. (orig./GL)

A Community of Congruence among Secondary Social Studies Teachers: A Case Study

Science.gov (United States)

Province, Rachael

2012-01-01

The purpose of this case study was to explore the community of one purposely selected department of secondary social studies teachers. I aimed to provide insight into the nature of one community of congruence amid the many constraints and systemic pressures in school systems today. Many have suggested that education is a microcosm of larger…

A Multilevel Study of Students' Motivations of Studying Accounting: Implications for Employers

Science.gov (United States)

Law, Philip; Yuen, Desmond

2012-01-01

Purpose: The purpose of this study is to examine the influence of factors affecting students' choice of accounting as a study major in Hong Kong. Design/methodology/approach: Multinomial logistic regression and Hierarchical Generalized Linear Modeling (HGLM) are used to analyze the survey data for the level one and level two data, which is the…

Our World of 7 Billion: Population Studies in Today's Social Studies Classroom

Science.gov (United States)

Wasserman, Pamela

2011-01-01

The study of world population integrates so many themes and disciplines in the social studies because it encompasses all of human history--the rise of agriculture and civilizations, scientific progress, territorial conflicts, changing gender roles and more. It is also at the heart of human geography and how people came to dominate and alter the…

A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study)

NARCIS (Netherlands)

Meulenbelt, I.; Bijkerk, C.; Miedema, H.S.; Breedveld, F.C.; Hofman, A.; Valkenburg, H.A.; Pols, H.A.P.; Slagboom, P.E.; Duijn, C.M. van

1998-01-01

Objective - A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. Methods - Subjects aged 55-65 years were selected from a population-based study of which ROA at

Great Basin paleoenvironmental studies project

International Nuclear Information System (INIS)

1993-01-01

Project goals, project tasks, progress on tasks, and problems encountered are described and discussed for each of the studies that make up the Great Basin Paleoenvironmental Studies Project for Yucca Mountain. These studies are: Paleobotany, Paleofauna, Geomorphology, and Transportation. Budget summaries are also given for each of the studies and for the overall project

Economic Studies

Directory of Open Access Journals (Sweden)

A. V. Kholopov

2014-01-01

Full Text Available The establishment of the School of Economic Science at MGIMO was due to the necessity of the world economy research, and the need to prepare highly skilled specialists in international economics. The school is developing a number of areas, which reflect the Faculty structure. - Economic theory is one of the most important research areas, a kind of foundation of the School of Economic Science at MGIMO. Economic theory studies are carried out at the chair of Economic theory. "The course of economic theory" textbook was published in 1991, and later it was reprinted seven times. Over the past few years other textbooks and manuals have been published, including "Economics for Managers" by Professor S.N. Ivashkovskaya, which survived through five editions; "International Economics" - four editions and "History of Economic Thought" - three editions. - International Economic Relations are carried out by the Department of International Economic Relations and Foreign Economic Activity. Its establishment is associated with the prominent economist N.N. Lyubimov. In 1957 he with his colleagues published the first textbook on the subject which went through multiple republications. The editorial team of the textbook subsequently formed the pride of Soviet economic science - S.M. Menshikov, E.P. Pletnev, V.D. Schetinin. Since 2007, the chair of Foreign Economic Activities led by Doctor of Economics, Professor I. Platonova has been investigating the problems of improving the architecture of foreign economic network and the international competitiveness of Russia; - The history of the study of problems of the world economy at MGIMO begins in 1958 at the chair baring the same name. Since 1998, the department has been headed by Professor A. Bulatov; - The study of international monetary relations is based on the chair of International Finance, and is focused on addressing the fundamental scientific and practical problems; - The chair "Banks, monetary circulation

Toxicological Study of Ocimum sanctum Linn Leaves: Hematological, Biochemical, and Histopathological Studies

Directory of Open Access Journals (Sweden)

M. K. Gautam

2014-01-01

Full Text Available The present study was aimed to study the acute and subacute toxicity studies with orally administered 50% ethanolic leaves extract of Ocimum sanctum Linn (OSE. In acute toxicity tests, four groups of mice (n=6/group/sex were orally treated with doses of 200, 600, and 2000 mg/kg, and general behavior, adverse effects, and mortality were recorded for up to 14 days. In subacute toxicity study, rats received OSE by gavage at the doses of 200, 400, and 800 mg/kg/day (n=6/group/sex for 28 days, and biochemical, hematological, and histopathological changes in tissues (liver, kidney, spleen, heart, and testis/ovary were determined. OSE did not produce any hazardous symptoms or death and CNS and ANS toxicities in the acute toxicity test. Subacute treatment with OSE did not show any change in body weight, food and water consumption, and hematological and biochemical profiles. In addition, no change was observed both in macroscopic and microscopic aspects of vital organs in rats. Our result showed that Ocimum sanctum extract could be safe for human use.

A Study on the Spatial Abilities of Prospective Social Studies Teachers: A Mixed Method Research

Science.gov (United States)

Yurt, Eyüp; Tünkler, Vural

2016-01-01

This study investigated prospective social studies teachers' spatial abilities. It was conducted with 234 prospective teachers attending Social Studies Teaching departments at Education Faculties of two universities in Central and Southern Anatolia. This study, designed according to the explanatory-sequential design, is a mixed research method,…

Studying Organizations on Instagram

Directory of Open Access Journals (Sweden)

Uta Russmann

2016-10-01

Full Text Available With the rise of social media platforms based on the sharing of pictures and videos, the question of how such platforms should be studied arises. Previous research on social media (content has mainly focused on text (written words and the rather text-based social media platforms Twitter and Facebook. Drawing on research in the fields of visual, political, and business communication, we introduce a methodological framework to study the fast-growing image-sharing service Instagram. This methodological framework was developed to study political parties’ Instagram accounts and tested by means of a study of Swedish political parties during the 2014 election campaign. In this article, we adapt the framework to also study other types of organizations active on Instagram by focusing on the following main questions: Do organizations only use Instagram to share one-way information, focusing on disseminating information and self-presentation? Or is Instagram used for two-way communication to establish and cultivate organization-public relationships? We introduce and discuss the coding of variables with respect to four clusters: the perception of the posting, image management, integration, and interactivity.

Epidemiological studies on syncope

DEFF Research Database (Denmark)

Ruwald, Martin Huth

2013-01-01

of the patients play an essential role. In epidemiology these factors have major impact on the outcome of the patients. Until recently, even the definition of syncope differed from one study to another which has made literature reviews difficult. Traditionally the data on epidemiology of syncope has been taken...... from smaller studies from different clinical settings with wide differences in patient morbidity. Through the extensive Danish registries we examined the characteristics and prognosis of the patients hospitalized due to syncope in a nationwide study. The aims of the present thesis were to investigate......, prevalence and cardiovascular factors associated with the risk of syncope, 4) the prognosis in healthy individuals discharged after syncope, and 5) the prognosis of patients after syncope and evaluation of the CHADS2 score as a tool for short- and long-term risk prediction. The first studies of the present...

Study of Self-Efficacy Perceptions of Social Studies Teacher Candidates on Educational Internet Usage

Science.gov (United States)

Akman, Özkan

2016-01-01

This study aimed at examining the self-efficacy perceptions of social studies teacher candidates with respect to educational internet use. This research was conducted on a sample of 174 social studies teacher candidates enrolled in Gaziantep University Nizip Faculty of Education. The "Educational Internet Self-Efficacy Scale," developed…

The High/Scope Perry Preschool Study: A Case Study in Random Assignment.

Science.gov (United States)

Schweinhart, Lawrence J.

2000-01-01

Studied the long-term benefits of preschool programs for young children living in poverty in the High/Scope Perry Preschool Study, which examined the lives of 123 African Americans randomly divided into a preschool treatment group and a no-preschool comparison group. Cost-benefit analyses of data on these students to age 27 show beneficial effects…

Routledge companion to intelligence studies

CERN Document Server

Dover, Robert; Hillebrand, Claudia

2013-01-01

The Routledge Companion to Intelligence Studies provides a broad overview of the growing field of intelligence studies. The recent growth of interest in intelligence and security studies has led to an increased demand for popular depictions of intelligence and reference works to explain the architecture and underpinnings of intelligence activity. Divided into five comprehensive sections, this Companion provides a strong survey of the cutting-edge research in the field of intelligence studies: Part I: The evolution of intelligence studies; Part II: Abstract approaches to intelligence; Part III: Historical approaches to intelligence; Part IV: Systems of intelligence; Part V: Contemporary challenges. With a broad focus on the origins, practices and nature of intelligence, the book not only addresses classical issues, but also examines topics of recent interest in security studies. The overarching aim is to reveal the rich tapestry of intelligence studies in both a sophisticated and accessible way. This Companion...

Machismo, Marianismo, and Negative Cognitive-Emotional Factors: Findings From the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.

Science.gov (United States)

Nuñez, Alicia; González, Patricia; Talavera, Gregory A; Sanchez-Johnsen, Lisa; Roesch, Scott C; Davis, Sonia M; Arguelles, William; Womack, Veronica Y; Ostrovsky, Natania W; Ojeda, Lizette; Penedo, Frank J; Gallo, Linda C

2016-11-01

There is limited research on the traditional Hispanic male and female gender roles of machismo and marianismo, respectively, in relation to negative cognitions and emotions. Given the vulnerability of Hispanics to negative cognitions and emotions, it is important to examine sociocultural correlates of emotional distress. Therefore, we examined associations of machismo and marianismo with negative cognitive-emotional factors (i.e., depression symptoms; cynical hostility; and trait anxiety and anger) in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study, a cross-sectional cohort study of sociocultural and psychosocial correlates of cardiometabolic health. Participants were aged 18-74 years and self-identified as Hispanic of Central American, Cuban, Dominican, Mexican, Puerto Rican, South American, and other Hispanic background ( N = 4,426). Results revealed that specific components of machismo (traditional machismo) and marianismo (family and spiritual pillar dimensions) were associated with higher levels of negative cognitions and emotions after adjusting for socio-demographic factors ( p < .05); these associations remained consistent across sex, Hispanic background group, and acculturation. Findings can inform mental health interventions and contribute to our understanding of the importance of gender role socialization in the context of self-reported negative cognitive-emotional factors in Hispanics.

Building Transdisciplinary Environmental Studies

DEFF Research Database (Denmark)

Holm, Jesper

We will in this paper approach the challenge of building integrated environmental studies by presenting a crude frame of analysis which take into account both the physical aspects and the social-discursive articulations of environmental problems. This framework partly mirrors the approach of our...... department (Dept. of Environment, Technology and Social Studies, Roskilde University), and has originally in another version been presented in the book “Miljøregulering - tværvidenskabelige studier (Environmental Regulation. Interdisciplinary Studies)” (Holm, Kjærgård & Pedersen eds. 1997, in Danish) written...

Study of copper fluorination

International Nuclear Information System (INIS)

Gillardeau, J.

1967-02-01

This report deals with the action of fluorine on copper. Comprehensive descriptions are given of the particular technological methods and of the preparation of the reactants. This fluorination reaction has been studied at medium and low fluorine pressures. A nucleation and growth phenomenon is described. The influence of a pollution of the gas phase on the fluorination process is described. The solid-state reaction between cupric fluoride and cooper has also been studied. A special study has been made of the growth of copper deposits by thermal decomposition of gaseous fluorides. (author) [fr

Study designs may influence results

DEFF Research Database (Denmark)

Johansen, Christoffer; Schüz, Joachim; Andreasen, Anne-Marie Serena

2017-01-01

appeared to show an inverse association, whereas nested case-control and cohort studies showed no association. For allergies, the inverse association was observed irrespective of study design. We recommend that the questionnaire-based case-control design be placed lower in the hierarchy of studies...... for establishing cause-and-effect for diseases such as glioma. We suggest that a state-of-the-art case-control study should, as a minimum, be accompanied by extensive validation of the exposure assessment methods and the representativeness of the study sample with regard to the exposures of interest. Otherwise...

Studies of Discourse and Governmentality

DEFF Research Database (Denmark)

have attempted to critically rethink Foucault’s ideas. This is the first volume that attempts to revisit and expand studies of governmentality by connecting it to the theories and methods of discourse analysis. The volume draws on different theoretical stances and methodological approaches including...... critical discourse analysis, conversation analysis, dialogic analysis, multimodal discourse analysis, the discourse-historical approach, corpus analysis and French discourse analysis. The volume is relevant to students and scholars in the fields of critical discourse studies, conversation analysis......, international studies, environmental studies, political science, public policy and organisation studies....

Introduction de compétences managériales dans les cours et tribunaux belges

Directory of Open Access Journals (Sweden)

David Delvaux

2010-02-01

Full Text Available Depuis quelques années et jusqu’à ce jour, les Cours et tribunaux belges sont le théâtre d’un vaste processus de « modernisation ». Depuis l’affaire Dutroux – qui a révélé les dysfonctionnements de la Justice et de la police belge –, on ne compte plus les initiatives visant à améliorer la « qualité » de l’appareil judiciaire. Pour mener à bien cet objectif, des dispositifs de différentes natures ont été développés. Dans le cadre de cette contribution, nous proposons d’étudier l’un d’entre eux : l’introduction de conseillers en gestion des ressources humaines dans certaines juridictions du pays. En nous inscrivant dans la lignée des travaux de sociologie des organisations, nous posons l’hypothèse que l’apparition d’un nouvel acteur devrait mener à une réévaluation des rôles, des stratégies et des comportements du système d’action local. Cependant, à l’issue de nos observations, l’impact du dispositif apparait faible. Ce qui nous mène à redéfinir notre hypothèse et à envisager ces conseillers comme des « opérateurs cognitifs » du changement. En envisageant l’action de ces conseillers comme le résultat d’un processus, il a été possible de mettre au jour les idéologies dont ce dispositif est porteur, ainsi que l’émergence de représentations collectives susceptibles de fournir un nouveau référent commun, un nouvel « éthos professionnel ».The introduction of "human resources advisers" in several courts’ staff in BelgiumA large-scale process of "modernization" has taken place in Belgian courts in the past few years. Since the Dutroux scandal, which underlined the dysfunctions of Belgian courts and police, many initiatives have been taken in order to improve the quality of Justice. Various categories of instruments have been developed to achieve this purpose. This article focuses on one of them: the introduction of "human resources advisers" in several

The Study of Butterflies

Indian Academy of Sciences (India)

The Study of Butterflies. 3. Intra-specific ... study of chitinous parts of the genitalia, especially of males proved a .... not known to affect mating habits in any way. We now .... such random interactions as well as modifications caused by external ...

Missouri airport investment study

Science.gov (United States)

The studys purpose is to provide MoDOT with insight to the potential ROI for airport : investments in terms of economic development. To do so, this study addresses two central : objectives: first, an approach to evaluate airport investments; and s...

The Study of Algae

Science.gov (United States)

Rushforth, Samuel R.

1977-01-01

Included in this introduction to the study of algae are drawings of commonly encountered freshwater algae, a summary of the importance of algae, descriptions of the seven major groups of algae, and techniques for collection and study of algae. (CS)

CASE STUDY

African Journals Online (AJOL)

2011-06-02

Jun 2, 2011 ... immunosuppression associated with HIV/AIDS puts them at a higher risk of developing oesophageal cancer. 47. CASE STUDY. A 49-year-old man was diagnosed as HIV infected, with a CD4 count of 60 cells/µl. He was started on an antiretroviral treatment regimen comprising zidovudine, lamivudine and ...

Hydrogeological study

International Nuclear Information System (INIS)

Massa, E.; Heinzen, W.; Santana, J.

1987-01-01

This work shows the hydrogeological study and well drilling carried out in the Teaching Formation Institute San Jose de Mayo Province Uruguay. It was developed a geological review in the National Directorate of Geology and Mining data base as well as field working, geology and hydrogeology recognition and area well drilling inventory.

Contemplative Media Studies

Directory of Open Access Journals (Sweden)

Kevin Healey

2015-08-01

Full Text Available The psychological and socio-economic implications of digital technologies call for scholarship that engages questions about the nature of human consciousness, the construction of the self and the ethics of technical development. In this article, I outline a framework for an approach called contemplative media studies. This approach incorporates several different scholarly threads, namely: via critical political-economic media scholarship, a focus on achieving social and economic justice through policy initiatives and structural reform; via media and religious scholarship, an interest in the religious dimensions of digital culture and the role of media in shaping religious identity; and via contemplative studies, an appreciation of the applicability of contemplative principles to research methods and theory. This framework allows us to examine the spiritual ideology that drives the construction of commercial digital platforms and to ask whether alternative platforms might better catalyze human development. Anchored in a critical commitment to socio-economic justice, contemplative media studies is aimed at articulating an ethically-responsive and economically-sustainable architecture of human flourishing.

Reproducing a Prospective Clinical Study as a Computational Retrospective Study in MIMIC-II.

Science.gov (United States)

Kury, Fabrício S P; Huser, Vojtech; Cimino, James J

2015-01-01

In this paper we sought to reproduce, as a computational retrospective study in an EHR database (MIMIC-II), a recent large prospective clinical study: the 2013 publication, by the Japanese Association for Acute Medicine (JAAM), about disseminated intravascular coagulation, in the journal Critical Care (PMID: 23787004). We designed in SQL and Java a set of electronic phenotypes that reproduced the study's data sampling, and used R to perform the same statistical inference procedures. All produced source code is available online at https://github.com/fabkury/paamia2015. Our program identified 2,257 eligible patients in MIMIC-II, and the results remarkably agreed with the prospective study. A minority of the needed data elements was not found in MIMIC-II, and statistically significant inferences were possible in the majority of the cases.

Study Gaps Relevant to Use of Complementary Medicine in Patients With Leukemia: A Review Study

Directory of Open Access Journals (Sweden)

Miladinia

2016-04-01

Full Text Available Context A review of the literature of recent decades has shown that few studies have been conducted on the effects of various types of complementary medicine on patients with leukemia. Therefore, the present study aimed to find research gaps in the use of different types of complementary medicine in patients with leukemia to be applied in future studies. Evidence Acquisition The present study was a review-type design based on a review of the literature on different types of complementary medicine in patients with leukemia, up to 2015. The search was conducted through electronic databases and search engines. According to the inclusion and exclusion criteria, 8 studies which had been conducted on the use of complementary medicine in patients with leukemia were selected for the identification of gaps. Results The overall results showed that few studies have been conducted on the use of exercise, massage therapy, music therapy, acupressure, and healing touch in patients with leukemia, and these subjects are potential research areas for many different studies. However, no studies have been carried out on the effects of acupuncture, relaxation, and yoga on these patients. Conclusions The results of this review showed that the number of studies on the use of complementary medicine in leukemia patients is very limited (especially in Iran, and it can be the subject of numerous studies in the future.

The study design and methodology for the ARCHER study - adolescent rural cohort study of hormones, health, education, environments and relationships

Directory of Open Access Journals (Sweden)

Steinbeck Katharine

2012-09-01

Full Text Available Abstract Background Adolescence is characterized by marked psychosocial, behavioural and biological changes and represents a critical life transition through which adult health and well-being are established. Substantial research confirms the role of psycho-social and environmental influences on this transition, but objective research examining the role of puberty hormones, testosterone in males and oestradiol in females (as biomarkers of puberty on adolescent events is lacking. Neither has the tempo of puberty, the time from onset to completion of puberty within an individual been studied, nor the interaction between age of onset and tempo. This study has been designed to provide evidence on the relationship between reproductive hormones and the tempo of their rise to adult levels, and adolescent behaviour, health and wellbeing. Methods/Design The ARCHER study is a multidisciplinary, prospective, longitudinal cohort study in 400 adolescents to be conducted in two centres in regional Australia in the State of New South Wales. The overall aim is to determine how changes over time in puberty hormones independently affect the study endpoints which describe universal and risk behaviours, mental health and physical status in adolescents. Recruitment will commence in school grades 5, 6 and 7 (10–12 years of age. Data collection includes participant and parent questionnaires, anthropometry, blood and urine collection and geocoding. Data analysis will include testing the reliability and validity of the chosen measures of puberty for subsequent statistical modeling to assess the impact over time of tempo and onset of puberty (and their interaction and mean-level repeated measures analyses to explore for significant upward and downward shifts on target outcomes as a function of main effects. Discussion The strengths of this study include enrollment starting in the earliest stages of puberty, the use of frequent urine samples in addition to annual

Case studies in conservation science

Science.gov (United States)

Bisulca, Christina

The research presented in this dissertation covers three separate topics of conservation as defined by the National Science Foundation: 1) Materials Stabilization, Strengthening, Monitoring, and Repair; 2. Understanding Material Degradation and Aging; and 3) Materials and Structural Characterization of Cultural Heritage Objects (the 'technical study'). The first topic is addressed through a study to assess the consolidant tetraethoxysilane for the stabilization of alum treated wood. Falling under materials degradation studies is a study published in American Museum Novitates to understand how environmental conditions affect the aging of fossil resins from five different deposits. Two separate studies are included in technical study of cultural heritage objects which comprises the third research area of materials characterization. The first is a survey of red dyes used in Chinese paintings from the Ming Dynasty to the Early Republic (1364-1911). The second is a study of the pigments, dyes and binders used in Hawaiian barkcloth (kapa) from the 19th century.

Studies in Rheoencephalography (REG

Directory of Open Access Journals (Sweden)

Michael Bodo

2010-01-01

Full Text Available This article presents an overview of rheoencephalography (REG – electrical impedance measurements of the brain – and summarizes past and ongoing research to develop medical applications of REG for neuro-critical care and for primary prevention of stroke and cardiovascular disease. The availability of advanced electronics and computation has opened up the potential for use of REG technology as a noninvasive, continuous and inexpensive brain monitor for military and civilian applications. The clinical background information presented here introduces physiological and clinical environments where REG has potential for use in research and clinical settings. REG studies over the past three decades have involved in vitro and in vivo groups (animal and human, including more than 1500 measurements and related electronic and computational results and practical applications. In vitro studies helped researchers understand the flow/volume relationship between Doppler ultrasound and electrical impedance signals and supported development of REG data processing methods. In animal studies, REG was used to monitor the lower limit of cerebral blood flow (CBF autoregulation (AR using a newly developed algorithm. These animal studies also confirmed correlations between REG and measurements of carotid flow (CF and intracranial pressure (ICP. Human studies confirmed the applicability of REG for detecting cerebrovascular alteration, demonstrating the usefulness of REG in the field of stroke/cardio-vascular disease prevention. In these studies, REG was compared to known stroke risk factors and to results obtained using carotid ultrasound measurements. An intelligent REG system (Cerberus has been developed for primary stroke prevention. In these studies, the biologically relevant variables of the REG signal were pulse amplitude (minimum – maximum distance and duration of the anacrotic (rising portion of the REG pulse wave. The principal limitation of REG for

Assurance of Learning and Study Abroad: A Case Study

Science.gov (United States)

Rexeisen, Richard J.; Al-Khatib, Jamal

2009-01-01

Most academic programs are now held accountable for measuring student-learning outcomes. This article reports the results of an assurance of learning (AOL) project designed to measure the impact of study abroad on the development of ethical reasoning, intercultural sensitivity, and environmental attitudes. The Association to Advance Collegiate…

Electron microscope studies

International Nuclear Information System (INIS)

Crewe, A.V.; Kapp, O.H.

1991-01-01

This year our laboratory has continued to make progress in the design of electron-optical systems, in the study of structure-function relationships of large multi-subunit proteins, in the development of new image processing software and in achieving a workable sub-angstrom STEM. We present an algebraic approach to the symmetrical Einzel (unipotential) lens wherein we simplify the analysis by specifying a field shape that meets some preferred set of boundary or other conditions and then calculate the fields. In a second study we generalize this approach to study of three element electrostatic lenses of which the symmetrical Einzel lens is a particular form. The purpose is to develop a method for assisting in the design of a lens for a particular purpose. In our biological work we study a stable and functional dodecameric complex of globin chains from the hemoglobin of Lumbricus terrestris. This is a complex lacking the ''linker'' subunit first imaged in this lab and required for maintenance of the native structure. In addition, we do a complete work-up on the hemoglobin of the marine polychaete Eudistylia vancouverii demonstrating the presence of a hierarchy of globin complexes. We demonstrate stable field-emission in the sub-angstrom STEM and the preliminary alignment of the beam. We continue our exploration of a algorithms for alignment of sequences of protein and DNA. Our computer facilities now include four second generation RISC workstations and we continue to take increasing advantage of the floating-point and graphical performance of these devices

Indonesia country study

Energy Technology Data Exchange (ETDEWEB)

1999-09-01

This study demonstrated the use of MARKAL model in carbon mitigation analysis for both energy and forestry sector. Four scenarios were used namely: 1. EbFb (baseline scenario). In this scenario, mitigation technologies in the energy sector were not included in the model and no target was set up for increasing net carbon uptake by forest activities. 2. EmFb. Mitigation technologies in the energy sector were included with the target of reducing cumulative net carbon emission by about 13% and activities in the forestry sectors were the same as those in baseline. 3. EbFm. Mitigation technologies in the energy sector were not included and the forestry activities were targeted to increase the carbon uptake so that the cumulative net carbon emission decreased by 13%. 4. EmFm. Mitigation technologies in the energy sector were included as well as forestry sector with target of reducing cumulative net carbon emission by about 35%. This study indicates that the MARKAL model has the potential to be used for mitigation analysis for both energy and forestry sectors. However, there are some limitations encountered during the study. The program is not able to accommodate the delayed emission from the forestry sector in a manner consistent to the treatment of emissions in the energy sector. In addition, there are some technical problems that still need to be resolved such as the inclusion of soil carbon uptake calculation in the model and the verification of carbon uptake calculation. In this study, all carbon uptakes was assumed to occur at the time of planting. (EHS) 37 refs.

Studies of Personality Disorders

DEFF Research Database (Denmark)

Ronningstam, Elsa; Simonsen, Erik; Oldham, John M

2014-01-01

The past 25 years have shown major advances in the studies of personality disorders. This collaborative article by the presidents, past and present, of ISSPD reflects on the progress within several significant areas of studies, i.e., assessment, neuroscience, treatment, prevention, advocacy...

Luminescence study of spodumene

International Nuclear Information System (INIS)

Isotani, S.; Fujii, A.T.; Antonini, R.; Pontuschka, W.M.; Rabani, S.R.; Furtado, W.W.

1990-02-01

A comparative study is made of the luminescence of five kinds of spodumene from Minas Gerais, Brazil, studied previously by optical absorption spectroscopy. Natural gemstones are used which, in the course of the experiments, were irradiated with X-rays. (L.C.) [pt

Multimodality in organization studies

DEFF Research Database (Denmark)

Van Leeuwen, Theo

2017-01-01

This afterword reviews the chapters in this volume and reflects on the synergies between organization and management studies and multimodality studies that emerge from the volume. These include the combination of strong sociological theorizing and detailed multimodal analysis, a focus on material...