WorldWideScience

Sample records for stringent operant response

  1. Circuitry linking the Csr and stringent response global regulatory systems.

    Science.gov (United States)

    Edwards, Adrianne N; Patterson-Fortin, Laura M; Vakulskas, Christopher A; Mercante, Jeffrey W; Potrykus, Katarzyna; Vinella, Daniel; Camacho, Martha I; Fields, Joshua A; Thompson, Stuart A; Georgellis, Dimitris; Cashel, Michael; Babitzke, Paul; Romeo, Tony

    2011-06-01

    CsrA protein regulates important cellular processes by binding to target mRNAs and altering their translation and/or stability. In Escherichia coli, CsrA binds to sRNAs, CsrB and CsrC, which sequester CsrA and antagonize its activity. Here, mRNAs for relA, spoT and dksA of the stringent response system were found among 721 different transcripts that copurified with CsrA. Many of the transcripts that copurified with CsrA were previously determined to respond to ppGpp and/or DksA. We examined multiple regulatory interactions between the Csr and stringent response systems. Most importantly, DksA and ppGpp robustly activated csrB/C transcription (10-fold), while they modestly activated csrA expression. We propose that CsrA-mediated regulation is relieved during the stringent response. Gel shift assays confirmed high affinity binding of CsrA to relA mRNA leader and weaker interactions with dksA and spoT. Reporter fusions, qRT-PCR and immunoblotting showed that CsrA repressed relA expression, and (p)ppGpp accumulation during stringent response was enhanced in a csrA mutant. CsrA had modest to negligible effects on dksA and spoT expression. Transcription of dksA was negatively autoregulated via a feedback loop that tended to mask CsrA effects. We propose that the Csr system fine-tunes the stringent response and discuss biological implications of the composite circuitry. © Published 2011. This article is a US Government work and is in the public domain in the USA.

  2. Phylogenetic analysis of proteins involved in the stringent response in plant cells.

    Science.gov (United States)

    Ito, Doshun; Ihara, Yuta; Nishihara, Hidenori; Masuda, Shinji

    2017-07-01

    The nucleotide (p)ppGpp is a second messenger that controls the stringent response in bacteria. The stringent response modifies expression of a large number of genes and metabolic processes and allows bacteria to survive under fluctuating environmental conditions. Recent genome sequencing analyses have revealed that genes responsible for the stringent response are also found in plants. These include (p)ppGpp synthases and hydrolases, RelA/SpoT homologs (RSHs), and the pppGpp-specific phosphatase GppA/Ppx. However, phylogenetic relationship between enzymes involved in bacterial and plant stringent responses is as yet generally unclear. Here, we investigated the origin and evolution of genes involved in the stringent response in plants. Phylogenetic analysis and primary structures of RSH homologs from different plant phyla (including Embryophyta, Charophyta, Chlorophyta, Rhodophyta and Glaucophyta) indicate that RSH gene families were introduced into plant cells by at least two independent lateral gene transfers from the bacterial Deinococcus-Thermus phylum and an unidentified bacterial phylum; alternatively, they were introduced into a proto-plant cell by a lateral gene transfer from the endosymbiotic cyanobacterium followed by gene loss of an ancestral RSH gene in the cyanobacterial linage. Phylogenetic analysis of gppA/ppx families indicated that plant gppA/ppx homologs form an individual cluster in the phylogenetic tree, and show a sister relationship with some bacterial gppA/ppx homologs. Although RSHs contain a plastidial transit peptide at the N terminus, GppA/Ppx homologs do not, suggesting that plant GppA/Ppx homologs function in the cytosol. These results reveal that a proto-plant cell obtained genes for the stringent response by lateral gene transfer events from different bacterial phyla and have utilized them to control metabolism in plastids and the cytosol.

  3. Rapid Curtailing of the Stringent Response by Toxin-Antitoxin Encoded mRNases

    DEFF Research Database (Denmark)

    Tian, Chengzhe; Roghanian, Mohammad; Jørgensen, Mikkel Girke

    2016-01-01

    Escherichia coli regulates its metabolism to adapt to changes in the environment, in particular to stressful downshifts in nutrient quality. Such shifts elicit the so-called stringent response coordinated by the alarmone guanosine tetra- and pentaphosphate [(p)ppGpp]. At sudden amino-acid (aa......RNase-encoding TA modules present in the wt strain. This observation suggested that toxins are part of the negative feedback to control the (p)ppGpp level during early stringent response. We built a ribosome trafficking model to evaluate the fold of increase in the RelA activity just after the onset of aa...... %. IMPORTANCE: The early stringent response elicited by amino-acid starvation is controlled by a sharp increase of the cellular (p)ppGpp level. Toxin-antitoxin encoded mRNases are activated by (p)ppGpp through enhanced degradation of antitoxins. The present work shows that this activation happens at a very...

  4. The stringent response regulates adaptation to darkness in the cyanobacterium Synechococcus elongatus.

    Science.gov (United States)

    Hood, Rachel D; Higgins, Sean A; Flamholz, Avi; Nichols, Robert J; Savage, David F

    2016-08-16

    The cyanobacterium Synechococcus elongatus relies upon photosynthesis to drive metabolism and growth. During darkness, Synechococcus stops growing, derives energy from its glycogen stores, and greatly decreases rates of macromolecular synthesis via unknown mechanisms. Here, we show that the stringent response, a stress response pathway whose genes are conserved across bacteria and plant plastids, contributes to this dark adaptation. Levels of the stringent response alarmone guanosine 3'-diphosphate 5'-diphosphate (ppGpp) rise after a shift from light to dark, indicating that darkness triggers the same response in cyanobacteria as starvation in heterotrophic bacteria. High levels of ppGpp are sufficient to stop growth and dramatically alter many aspects of cellular physiology, including levels of photosynthetic pigments and polyphosphate, DNA content, and the rate of translation. Cells unable to synthesize ppGpp display pronounced growth defects after exposure to darkness. The stringent response regulates expression of a number of genes in Synechococcus, including ribosomal hibernation promoting factor (hpf), which causes ribosomes to dimerize in the dark and may contribute to decreased translation. Although the metabolism of Synechococcus differentiates it from other model bacterial systems, the logic of the stringent response remains remarkably conserved, while at the same time having adapted to the unique stresses of the photosynthetic lifestyle.

  5. Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family

    DEFF Research Database (Denmark)

    Kristensen, Ole; Laurberg, Martin; Liljas, Anders

    2004-01-01

    Exopolyphosphatase/guanosine pentaphosphate phosphohydrolase (PPX/GPPA) enzymes play central roles in the bacterial stringent response induced by starvation. The high-resolution crystal structure of the putative Aquifex aeolicus PPX/GPPA phosphatase from the actin-like ATPase domain superfamily h...

  6. The Stringent Response Induced by Phosphate Limitation Promotes Purine Salvage in Agrobacterium fabrum.

    Science.gov (United States)

    Sivapragasam, Smitha; Deochand, Dinesh K; Meariman, Jacob K; Grove, Anne

    2017-10-31

    Agrobacterium fabrum induces tumor growth in susceptible plant species. The upregulation of virulence genes that occurs when the bacterium senses plant-derived compounds is enhanced by acidic pH and limiting inorganic phosphate. Nutrient starvation may also trigger the stringent response, and purine salvage is among the pathways expected to be favored under such conditions. We show here that phosphate limitation induces the stringent response, as evidenced by production of (p)ppGpp, and that the xdhCSML operon encoding the purine salvage enzyme xanthine dehydrogenase is upregulated ∼15-fold. The xdhCSML operon is under control of the TetR family transcription factor XdhR; direct binding of ppGpp to XdhR attenuates DNA binding, and the enhanced xdhCSML expression correlates with increased cellular levels of (p)ppGpp. Xanthine dehydrogenase may also divert purines away from salvage pathways to form urate, the ligand for the transcription factor PecS, which in the plant pathogen Dickeya dadantii is a key regulator of virulence gene expression. However, urate levels remain low under conditions that produce increased levels of xdhCSML expression, and neither acidic pH nor limiting phosphate results in induction of genes under control of PecS. Instead, expression of such genes is induced only by externally supplemented urate. Taken together, our data indicate that purine salvage is favored during the stringent response induced by phosphate starvation, suggesting that control of this pathway may constitute a novel approach to modulating virulence. Because bacterial purine catabolism appears to be unaffected, as evidenced by the absence of urate accumulation, we further propose that the PecS regulon is induced by only host-derived urate.

  7. The Stringent Response Promotes Antibiotic Resistance Dissemination by Regulating Integron Integrase Expression in Biofilms

    Directory of Open Access Journals (Sweden)

    Emilie Strugeon

    2016-08-01

    Full Text Available Class 1 integrons are genetic systems that enable bacteria to capture and express gene cassettes. These integrons, when isolated in clinical contexts, most often carry antibiotic resistance gene cassettes. They play a major role in the dissemination of antibiotic resistance among Gram-negative bacteria. The key element of integrons is the integrase, which allows gene cassettes to be acquired and shuffled. Planktonic culture experiments have shown that integrase expression is regulated by the bacterial SOS response. In natural settings, however, bacteria generally live in biofilms, which are characterized by strong antibiotic resilience and by increased expression of stress-related genes. Here, we report that under biofilm conditions, the stringent response, which is induced upon starvation, (i increases basal integrase and SOS regulon gene expression via induction of the SOS response and (ii exerts biofilm-specific regulation of the integrase via the Lon protease. This indicates that biofilm environments favor integron-mediated acquisition of antibiotic resistance and other adaptive functions encoded by gene cassettes.

  8. Stringently Defined Otitis Prone Children Demonstrate Deficient Naturally Induced Mucosal Antibody Response to Moraxella catarrhalis Proteins

    Directory of Open Access Journals (Sweden)

    Dabin Ren

    2017-08-01

    Full Text Available Moraxella catarrhalis (Mcat is a prominent mucosal pathogen causing acute otitis media (AOM. We studied Mcat nasopharyngeal (NP colonization, AOM frequency and mucosal antibody responses to four vaccine candidate Mcat proteins: outer membrane protein (OMP CD, oligopeptide permease (Opp A, hemagglutinin (Hag, and Pilin A clade 2 (PilA2 from stringently defined otitis prone (sOP children, who experience the greatest burden of disease, compared to non-otitis prone (NOP children. sOP children had higher NP colonization of Mcat (30 vs. 22%, P = 0.0003 and Mcat-caused AOM rates (49 vs. 24%, P < 0.0001 than NOP children. Natural acquisition of mucosal antibodies to Mcat proteins OMP CD (IgG, P < 0.0001, OppA (IgG, P = 0.018, Hag (IgG and IgA, both P < 0.0001, and PilA2 (IgA, P < 0.0001 was lower in sOP than NOP children. Higher levels of mucosal IgG to Hag (P = 0.039 and PilA2 (P = 0.0076, and IgA to OMP CD (P = 0.010, OppA (P = 0.030, and PilA2 (P = 0.043 were associated with lower carriage of Mcat in NOP but not sOP children. Higher levels of mucosal IgG to OMP CD (P = 0.0070 and Hag (P = 0.0003, and IgA to Hag (P = 0.0067 at asymptomatic colonization than those at onset of AOM were associated with significantly lower rate of Mcat NP colonization progressing to AOM in NOP compared to sOP children (3 vs. 26%, P < 0.0001. In conclusion, sOP children had a diminished mucosal antibody response to Mcat proteins, which was associated with higher frequencies of asymptomatic NP colonization and NP colonization progressing to Mcat-caused AOM. Enhancing Mcat antigen-specific mucosal immune responses to levels higher than achieved by natural exposure will be necessary to prevent AOM in sOP children.

  9. Role of the Stringent Stress Response in the Antibiotic Resistance Phenotype of Methicillin-Resistant Staphylococcus aureus.

    Science.gov (United States)

    Aedo, Sandra; Tomasz, Alexander

    2016-04-01

    Resistance to beta-lactam antibiotics in methicillin-resistantStaphylococcus aureus(MRSA) requires the presence of an acquired genetic determinant,mecAormecC, which encode penicillin-binding protein PBP2A or PBP2A', respectively. Although all MRSA strains share a mechanism of resistance, the phenotypic expression of beta-lactam resistance shows considerable strain-to-strain variation. The stringent stress response, a stress response that results from nutrient limitation, was shown to play a key role in determining the resistance level of an MRSA strain. In the present study, we validated the impact of the stringent stress response on transcription and translation ofmecAin the MRSA clinical isolate strain N315, which also carries known regulatory genes (mecI/mecR1/mecR2andblaI/blaR1) formecAtranscription. We showed that the impact of the stringent stress response on the resistance level may be restricted to beta-lactam resistance based on a "foreign" determinant such asmecA, as opposed to resistance based on mutations in the nativeS. aureusdeterminantpbpB(encoding PBP2). Our observations demonstrate that high-level resistance mediated by the stringent stress response follows the current model of beta-lactam resistance in which the native PBP2 protein is also essential for expression of the resistance phenotype. We also show that theStaphylococcus sciuri pbpDgene (also calledmecAI), the putative evolutionary precursor ofmecA, confers oxacillin resistance in anS. aureusstrain, generating a heterogeneous phenotype that can be converted to high and homogenous resistance by induction of the stringent stress response in the bacteria. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  10. Synthetic Peptides to Target Stringent Response-Controlled Virulence in a Pseudomonas aeruginosa Murine Cutaneous Infection Model

    Directory of Open Access Journals (Sweden)

    Daniel Pletzer

    2017-09-01

    Full Text Available Microorganisms continuously monitor their surroundings and adaptively respond to environmental cues. One way to cope with various stress-related situations is through the activation of the stringent stress response pathway. In Pseudomonas aeruginosa this pathway is controlled and coordinated by the activity of the RelA and SpoT enzymes that metabolize the small nucleotide secondary messenger molecule (pppGpp. Intracellular ppGpp concentrations are crucial in mediating adaptive responses and virulence. Targeting this cellular stress response has recently been the focus of an alternative approach to fight antibiotic resistant bacteria. Here, we examined the role of the stringent response in the virulence of P. aeruginosa PAO1 and the Liverpool epidemic strain LESB58. A ΔrelA/ΔspoT double mutant showed decreased cytotoxicity toward human epithelial cells, exhibited reduced hemolytic activity, and caused down-regulation of the expression of the alkaline protease aprA gene in stringent response mutants grown on blood agar plates. Promoter fusions of relA or spoT to a bioluminescence reporter gene revealed that both genes were expressed during the formation of cutaneous abscesses in mice. Intriguingly, virulence was attenuated in vivo by the ΔrelA/ΔspoT double mutant, but not the relA mutant nor the ΔrelA/ΔspoT complemented with either gene. Treatment of a cutaneous P. aeruginosa PAO1 infection with anti-biofilm peptides increased animal welfare, decreased dermonecrotic lesion sizes, and reduced bacterial numbers recovered from abscesses, resembling the phenotype of the ΔrelA/ΔspoT infection. It was previously demonstrated by our lab that ppGpp could be targeted by synthetic peptides; here we demonstrated that spoT promoter activity was suppressed during cutaneous abscess formation by treatment with peptides DJK-5 and 1018, and that a peptide-treated relA complemented stringent response double mutant strain exhibited reduced peptide

  11. A rapid response air quality analysis system for use in projects having stringent quality assurance requirements

    International Nuclear Information System (INIS)

    Bowman, A.W.

    1990-01-01

    This paper describes an approach to solve air quality problems which frequently occur during iterations of the baseline change process. From a schedule standpoint, it is desirable to perform this evaluation in as short a time as possible while budgetary pressures limit the size of the staff available to do the work. Without a method in place to deal with baseline change proposal requests the environment analysts may not be able to produce the analysis results in the time frame expected. Using a concept called the Rapid Response Air Quality Analysis System (RAAS), the problems of timing and cost become tractable. The system could be adapted to assess other atmospheric pathway impacts, e.g., acoustics or visibility. The air quality analysis system used to perform the EA analysis (EA) for the Salt Repository Project (part of the Civilian Radioactive Waste Management Program), and later to evaluate the consequences of proposed baseline changes, consists of three components: Emission source data files; Emission rates contained in spreadsheets; Impact assessment model codes. The spreadsheets contain user-written codes (macros) that calculate emission rates from (1) emission source data (e.g., numbers and locations of sources, detailed operating schedules, and source specifications including horsepower, load factor, and duty cycle); (2) emission factors such as those published by the U.S. Environmental Protection Agency, and (3) control efficiencies

  12. The mechanism of heterogeneous beta-lactam resistance in MRSA: key role of the stringent stress response.

    Directory of Open Access Journals (Sweden)

    Choonkeun Kim

    Full Text Available All methicillin resistant S. aureus (MRSA strains carry an acquired genetic determinant--mecA or mecC--which encode for a low affinity penicillin binding protein -PBP2A or PBP2A'--that can continue the catalysis of peptidoglycan transpeptidation in the presence of high concentrations of beta-lactam antibiotics which would inhibit the native PBPs normally involved with the synthesis of staphylococcal cell wall peptidoglycan. In contrast to this common genetic and biochemical mechanism carried by all MRSA strains, the level of beta-lactam antibiotic resistance shows a very wide strain to strain variation, the mechanism of which has remained poorly understood. The overwhelming majority of MRSA strains produce a unique--heterogeneous--phenotype in which the great majority of the bacteria exhibit very poor resistance often close to the MIC value of susceptible S. aureus strains. However, cultures of such heterogeneously resistant MRSA strains also contain subpopulations of bacteria with extremely high beta-lactam MIC values and the resistance level and frequency of the highly resistant cells in such strain is a characteristic of the particular MRSA clone. In the study described in this communication, we used a variety of experimental models to understand the mechanism of heterogeneous beta-lactam resistance. Methicillin-susceptible S. aureus (MSSA that received the mecA determinant in the laboratory either on a plasmid or in the form of a chromosomal SCCmec cassette, generated heterogeneously resistant cultures and the highly resistant subpopulations that emerged in these models had increased levels of PBP2A and were composed of bacteria in which the stringent stress response was induced. Each of the major heterogeneously resistant clones of MRSA clinical isolates could be converted to express high level and homogeneous resistance if the growth medium contained an inducer of the stringent stress response.

  13. Stringently Defined Otitis Prone Children Demonstrate Deficient Naturally Induced Mucosal Antibody Response toMoraxella catarrhalisProteins.

    Science.gov (United States)

    Ren, Dabin; Murphy, Timothy F; Lafontaine, Eric R; Pichichero, Michael E

    2017-01-01

    Moraxella catarrhalis ( Mcat ) is a prominent mucosal pathogen causing acute otitis media (AOM). We studied Mcat nasopharyngeal (NP) colonization, AOM frequency and mucosal antibody responses to four vaccine candidate Mcat proteins: outer membrane protein (OMP) CD, oligopeptide permease (Opp) A, hemagglutinin (Hag), and Pilin A clade 2 (PilA2) from stringently defined otitis prone (sOP) children, who experience the greatest burden of disease, compared to non-otitis prone (NOP) children. sOP children had higher NP colonization of Mcat (30 vs. 22%, P  = 0.0003) and Mcat -caused AOM rates (49 vs. 24%, P  P  P  = 0.018), Hag (IgG and IgA, both P  P  P  = 0.039) and PilA2 ( P  = 0.0076), and IgA to OMP CD ( P  = 0.010), OppA ( P  = 0.030), and PilA2 ( P  = 0.043) were associated with lower carriage of Mcat in NOP but not sOP children. Higher levels of mucosal IgG to OMP CD ( P  = 0.0070) and Hag ( P  = 0.0003), and IgA to Hag ( P  = 0.0067) at asymptomatic colonization than those at onset of AOM were associated with significantly lower rate of Mcat NP colonization progressing to AOM in NOP compared to sOP children (3 vs. 26%, P  NP colonization and NP colonization progressing to Mcat -caused AOM. Enhancing Mcat antigen-specific mucosal immune responses to levels higher than achieved by natural exposure will be necessary to prevent AOM in sOP children.

  14. Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (pppGpp synthase

    Directory of Open Access Journals (Sweden)

    Kalinowski Jörn

    2006-09-01

    Full Text Available Background The stringent response is the initial reaction of microorganisms to nutritional stress. During stringent response the small nucleotides (pppGpp act as global regulators and reprogram bacterial transcription. In this work, the genetic network controlled by the stringent response was characterized in the amino acid-producing Corynebacterium glutamicum. Results The transcriptome of a C. glutamicum rel gene deletion mutant, unable to synthesize (pppGpp and to induce the stringent response, was compared with that of its rel-proficient parent strain by microarray analysis. A total of 357 genes were found to be transcribed differentially in the rel-deficient mutant strain. In a second experiment, the stringent response was induced by addition of DL-serine hydroxamate (SHX in early exponential growth phase. The time point of the maximal effect on transcription was determined by real-time RT-PCR using the histidine and serine biosynthetic genes. Transcription of all of these genes reached a maximum at 10 minutes after SHX addition. Microarray experiments were performed comparing the transcriptomes of SHX-induced cultures of the rel-proficient strain and the rel mutant. The differentially expressed genes were grouped into three classes. Class A comprises genes which are differentially regulated only in the presence of an intact rel gene. This class includes the non-essential sigma factor gene sigB which was upregulated and a large number of genes involved in nitrogen metabolism which were downregulated. Class B comprises genes which were differentially regulated in response to SHX in both strains, independent of the rel gene. A large number of genes encoding ribosomal proteins fall into this class, all being downregulated. Class C comprises genes which were differentially regulated in response to SHX only in the rel mutant. This class includes genes encoding putative stress proteins and global transcriptional regulators that might be

  15. New insights into the regulatory pathways associated with the activation of the stringent response in bacterial resistance to the PBP2-targeted antibiotics, mecillinam and OP0595/RG6080.

    Science.gov (United States)

    Doumith, M; Mushtaq, S; Livermore, D M; Woodford, N

    2016-10-01

    The diazabicyclooctane β-lactamase inhibitor OP0595 (RG6080) also acts as an antibiotic, targeting PBP2 in Enterobacteriaceae, but this activity is vulnerable to mutational resistance. We used WGS to investigate the basis of this resistance. Twenty OP0595-selected mutants, comprising four derived from each of five different Escherichia coli strains, were sequenced on Illumina HiSeq. Reads from each mutant were mapped to the assembled genome of the corresponding parent. A variant-calling file generated with Samtools was parsed to determine genetic alterations. Besides OP0595, the mutants consistently showed decreased susceptibility to mecillinam, which likewise targets PBP2, and grew as stable round forms in the presence of subinhibitory concentrations of OP0595. Among the 20 mutants, 18 had alterations in genes encoding tRNA synthase and modification functions liable to induce expression of the RpoS sigma factor through activation of the stringent response or had mutations suppressing inactivators of RpoS or the stringent response signal-degrading enzyme, SpoT. TolB was inactivated in one mutant: this activates RcsBC regulation and was previously associated with mecillinam resistance. The mechanism of resistance remained unidentified in one mutant. Both the RpoS and RcsBC systems regulate genes of cell division, including ftsAQZ that can compensate for loss or inhibition of PBP2, allowing survival of the challenged bacteria as stable round forms, as seen. WGS identified the global stringent response signal, entailing induction of RpoS, as the main mediator of mutational resistance to OP0595 in E. coli. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  16. Training and Tactical Operationally Responsive Space Operations

    Science.gov (United States)

    Sorensen, B.; Strunce, R., Jr.

    Current space assets managed by traditional space system control resources provide communication, navigation, intelligence, surveillance, and reconnaissance (ISR) capabilities using satellites that are designed for long life and high reliability. The next generation Operationally Responsive Space (ORS) systems are aimed at providing operational space capabilities which will provide flexibility and responsiveness to the tactical battlefield commander. These capabilities do not exist today. The ORS communication, navigation, and ISR satellites are being designed to replace or supplement existing systems in order to enhance the current space force. These systems are expected to rapidly meet near term space needs of the tactical forces. The ORS concept includes new tactical satellites specifically designed to support contingency operations such as increased communication bandwidth and ISR imagery over the theater for a limited period to support air, ground, and naval force mission. The Concept of Operations (CONOPS) that exists today specifies that in addition to operational control of the satellite, the tasking and scheduling of the ORS tactical satellite for mission data collection in support of the tactical warfighter will be accomplished within the Virtual Mission Operations Center (VMOC). This is very similar to what is currently being accomplished in a fixed Mission Operations Center on existing traditional ISR satellites. The VMOC is merely a distributed environment and the CONOPS remain virtually the same. As a result, there is a significant drawback to the current ORS CONOPS that does not account for the full potential of the ORS paradigm for supporting tactical forces. Although the CONOPS approach may be appropriate for experimental Tactical Satellites (TacSat), it ignores the issues associated with the In-Theater Commander's need to own and operate his dedicated TacSat for most effective warfighting as well as the Warfighter specific CONOPS. What is needed

  17. Making Corporate Social Responsibility Operable

    OpenAIRE

    Frere, Claudia

    2007-01-01

    This research project investigates the nature of making CSR operable within the financial services industry. It reviews the external context in which firms engage in CSR, their response and how these factors influence internal CSR management and operations. Drawing from a multi-perspective discipline, the research incorporates CSR concepts and theoretical implications from market and non-market motivations and strategic management perspectives of network and institutional theories. Concept...

  18. Operational safety - the IAEA response

    International Nuclear Information System (INIS)

    Rosen, M.

    1984-01-01

    Nuclear safety is an international issue. The role of the International Atomic Energy Agency is growing because it offers a centre for contact and exchange between East and West, North and South. New initiatives are under way to intensify international co-operative safety efforts through exchange of information on abnormal events at nuclear power plants, and through greater sharing of safety research results. Emergency preparedness also lends itself to international co-operation. A report has been prepared on the need for establishing mutual emergency assistance. By analysing possible constraints to bilateral or multinational efforts in advance, a basis for agreement at the time of an emergency is being worked out. Safety standards have been developed in several areas. The NUSS Codes and Guides, now almost complete, make available to countries starting a nuclear power programme a coherent set of nuclear safety standards. A revised set of Basic Safety Standards for Radiation Protection has been issued in 1982. (author)

  19. DRONE OPERATORS – LEGAL RESPONSIBILITY

    Directory of Open Access Journals (Sweden)

    Andrei-Alexandru STOICA

    2016-06-01

    Full Text Available Drones or unmanned or remote vehicles represent a new generation of devices that were designed to help mankind achieve better results in areas that were proven to hazardous. By developing drones, new areas of economic activities have been unlocked for better exploitation, but at the same time, the lack of a proper legal system to back-up the new technology allowed a new wave of gray-lined uses of drones that must be tackled. As the Director of the 21st Century Defense Initiative at the Brookings Institute1 explains in an interview in 2012 that “a revolutionary technology is a game-changing technology on a historic level. It is technology like gunpowder, or the steam engine, or the atomic bomb”. With this in mind, drones mark the revolution to carry out strikes from thousands of kilometers away, while also ensuring a permanent eye in the sky for both military and also law enforcement operations. The aforementioned facts are just small percentages of what a drone is truly capable of and its full potential will only be unlocked once artificial intelligence will become an integral part of robotics.

  20. Simulation of Operators' Response in Emergencies

    DEFF Research Database (Denmark)

    Rasmussen, Jens

    1986-01-01

    For the simulation of the accidental course of events in industrial process plants, a model is needed of operators' response to the cues presented by the system. A model is proposed, based on the simplifications which can be made when restricting attention to the operator functions having...... significants for a probabilistic risk analysis, and to only skill and rule based performance, i.e., to responses in the early phase of an accident. The model is based on Brunswik's lens model, a model of the normal task repertoire, and on a taxonomy of human errors. To bring the model in perspective, a review...

  1. Crystallization of a stringent response factor from Aquifex aeolicus

    DEFF Research Database (Denmark)

    Kristensen, Ole; Laurberg, Martin; Gajhede, Michael

    2002-01-01

    a = 50.8, b = 70.3, c = 90.9 A. Methionine residues were introduced by mutation and deliberate oxidation of the protein allowed us to produce additional crystal forms with reproducible diffraction ability and increased phasing potential. This is the first report on the crystallization of a member...

  2. Crystallization of a stringent response factor from Aquifex aeolicus

    DEFF Research Database (Denmark)

    Kristensen, Ole; Laurberg, Martin; Gajhede, Michael

    2002-01-01

    a = 50.8, b = 70.3, c = 90.9 A. Methionine residues were introduced by mutation and deliberate oxidation of the protein allowed us to produce additional crystal forms with reproducible diffraction ability and increased phasing potential. This is the first report on the crystallization of a member...... of the Ppx/GppA phosphatase family....

  3. The effect of increasingly stringent diagnostic criteria on sex ...

    African Journals Online (AJOL)

    Sex differences in premorbid function and symptomatology were examined as increasingly stringent criteria for schizophrenia were applied to 182 male and 139 female . psychotic patients. The male/female ratio rose from 1.6 among those meeting the CATEGO 'broad' criteria for schizophrenia to 3.7 among those satisfying ...

  4. Simulation of operators' response in emergencies

    International Nuclear Information System (INIS)

    Rasmussen, J.

    1986-09-01

    For the simulation of the accidential course of events in industrial process plants, a model is needed of operators' response to the cues presented by the system. A model is proposed, based on the simplifications which can be made when restricting attention to the operator functions having significants for a probabilistic risk analysis, and to anly skill and rule based performance, i.e., to responses in the early phase of an accident. The model is based on Brunswik's lens model, a model of the normal task repertoire, and on a taxonomy of human errors. To bring the model in perspective, a review of the state of the art of cognitive models of human behaviour is included. (author)

  5. Is ionizing radiation regulated more stringently than chemical carcinogens

    International Nuclear Information System (INIS)

    Travis, C.C.; Pack, S.R.; Hattemer-Frey, H.A.

    1989-01-01

    It is widely believed that United States government agencies regulate exposure to ionizing radiation more stringently than exposure to chemical carcinogens. It is difficult to verify this perception, however, because chemical carcinogens and ionizing radiation are regulated using vastly different strategies. Chemical carcinogens are generally regulated individually. Regulators consider the risk of exposure to one chemical rather than the cumulative radiation exposure from all sources. Moreover, standards for chemical carcinogens are generally set in terms of quantities released or resultant environmental concentrations, while standards for ionizing radiation are set in terms of dose to the human body. Since chemicals and ionizing radiation cannot be compared on the basis of equal dose to the exposed individual, standards regulating chemicals and ionizing radiation cannot be compared directly. It is feasible, however, to compare the two sets of standards on the basis of equal risk to the exposed individual, assuming that standards for chemicals and ionizing radiation are equivalent if estimated risk levels are equitable. This paper compares risk levels associated with current standards for ionizing radiation and chemical carcinogens. The authors do not attempt to determine whether either type of risk is regulated too stringently or not stringently enough but endeavor only to ascertain if ionizing radiation is actually regulated more strictly than chemical carcinogens

  6. Flight Hardware Packaging Design for Stringent EMC Radiated Emission Requirements

    Science.gov (United States)

    Lortz, Charlene L.; Huang, Chi-Chien N.; Ravich, Joshua A.; Steiner, Carl N.

    2013-01-01

    This packaging design approach can help heritage hardware meet a flight project's stringent EMC radiated emissions requirement. The approach requires only minor modifications to a hardware's chassis and mainly concentrates on its connector interfaces. The solution is to raise the surface area where the connector is mounted by a few millimeters using a pedestal, and then wrapping with conductive tape from the cable backshell down to the surface-mounted connector. This design approach has been applied to JPL flight project subsystems. The EMC radiated emissions requirements for flight projects can vary from benign to mission critical. If the project's EMC requirements are stringent, the best approach to meet EMC requirements would be to design an EMC control program for the project early on and implement EMC design techniques starting with the circuit board layout. This is the ideal scenario for hardware that is built from scratch. Implementation of EMC radiated emissions mitigation techniques can mature as the design progresses, with minimal impact to the design cycle. The real challenge exists for hardware that is planned to be flown following a built-to-print approach, in which heritage hardware from a past project with a different set of requirements is expected to perform satisfactorily for a new project. With acceptance of heritage, the design would already be established (circuit board layout and components have already been pre-determined), and hence any radiated emissions mitigation techniques would only be applicable at the packaging level. The key is to take a heritage design with its known radiated emissions spectrum and repackage, or modify its chassis design so that it would have a better chance of meeting the new project s radiated emissions requirements.

  7. Comparison of urine iodine/creatinine ratio between patients following stringent and less stringent low iodine diet for radioiodine remnant ablation of thyroid cancer

    International Nuclear Information System (INIS)

    Roh, Jee Ho; Kim, Byung Il; Ha, Ji Su; Chang, Sei Joong; Shin, Hye Young; Choi, Joon Hyuk; Kim, Do Min; Kim, Chong Soon

    2006-01-01

    A low iodine diet (LID) for 1 ∼ 2 weeks is recommended for patients who undergoing radioiodine remnant ablation. However, the LID educations for patients are different among centers because there is no concrete recommendation for protocol of LID. In this investigation, we compared two representative types of LID protocols performed in several centers in Korea using urine iodine to creatinine tatio (urine I/Cr). From 2006, April to June, patients referred to our center for radioiodine remnant ablation of thyroid cancer from several local hospitals which had different LID protocols were included. We divided into two groups, stringent LID for 1 week and less stringent LID for 2 weeks, then measured their urine I/Cr ratio with spot urine when patients were admitted to the hospital. Total 27 patients were included in this investigation (M:F = 1:26; 13 in one-week stringent LID; 14 in two-week less stringent LID). Average of urine I/Cr ratio was 127.87 ± 78.52 μ g/g in stringent LID for 1 week, and 289.75 ± 188.24 μ g/g in less stringent LID for 2 weeks. It was significantly lower in stringent LID for 1 week group (ρ = 0.008). The number of patients whose urine I/Cr ratios were below 100 μ g/g was 6 of 13 in stringent LID for 1 week group, and 3 of 14 in less stringent LID for 2 weeks group. Stringent LID for 1 week resulted in better urinary I/Cr ratio in our investigation compared with the other protocol. However it still resulted in plenty of inadequate range of I/Cr ratio, so more stringent protocol such as stringent LID for 2 weeks is expected more desirable

  8. 47 CFR 76.956 - Cable operator response.

    Science.gov (United States)

    2010-10-01

    ... directed by the local franchising authority, a cable operator must file with the local franchise authority... filing. The cable operator must file its response with the local franchise authority via first class mail...

  9. 40 CFR 300.135 - Response operations.

    Science.gov (United States)

    2010-07-01

    ... PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY.... The basic framework for the response management structure is a system (e.g., a unified command system... party to achieve an effective and efficient response, where the OSC maintains authority. (e) The OSC/RPM...

  10. Airpower in Mass Atrocity Response Operations (MARO)

    Science.gov (United States)

    2012-06-01

    III, —Air Theory for the Twenty-First Century,“ Challenge and Response: Anticipating U.S. Military Security Concerns, ed. Karl P. Magyar (Maxwell AFB...for the Twenty-First Century,“ Challenge and Response: Anticipating U.S. Military Security Concerns, ed. Karl P. Magyar (Maxwell AFB, Ala.: Air

  11. Role and Responsibilities of the Operator

    International Nuclear Information System (INIS)

    Fox, M.; Bacon, A.

    2016-01-01

    As the world leader in the maritime transport of radioactive material (RAM) International Nuclear Service (INS) and its subsidiary, Pacific Nuclear Transport Limited (PNTL) have pioneered the standards for safe and secure transport operations. This paper will highlight these standards from an operator's perspective and provide an overview of how the company would respond to a safety or security related incident. In matching these standards against the national and international maritime regulations, INS will continue to lead the way on the worldwide transport of RAM thus supporting the nuclear fuel cycle and overall global threat reduction. (author)

  12. Extreme wind turbine response during operation

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Nielsen, S.R.K.

    2007-01-01

    load extrapolation is considered using techniques from structural reliability theory. Different simulation techniques to estimate extreme response characteristics are described and compared, including crude Monte Carlo simulation, Importance Sampling, and splitting methods such as the Russian Roulette...

  13. Operationally Responsive Spacecraft Using Electric Propulsion

    Science.gov (United States)

    2012-09-13

    orbit at or below an altitude of 700 km. The space shuttle and the International Space Station experience these constantly and must counter these...programs or significant changes in operations concepts. New threats in the international N 8-3 environment may demand change as rapid...Along-track Cross- trad : R.>iial Orientati:m Errors . Azimuth Nadir Angle OtherEnors T a:get altitude Sp>:eeraft clock f 1.0 1.0 1.0 0.0010

  14. Stringent cost management and preservation of safety culture, a contradiction?

    International Nuclear Information System (INIS)

    Petersen, Klaus; Pamme, H.

    2002-01-01

    Full text: Competition in the deregulated electricity market does not leave nuclear power plants unaffected. Hence the question is to answer, whether the safety is going to suffer under the cost pressure on the market. Therefore the target of NPP operator's cost management is to run plants at maximum availability and with optimized cost structures that lead to minimized specific generating costs. The c osts of safety , with their fixed-cost character, are elements of this cost structure. The process of economic optimization of the cost structure does not permit cost minimization on its own sake in the area of operation cost and fuel cost (front and back end). The basis of economical assessment rather must be the minimization of potential risks which could entail losses of availability. However, many investments like plant modifications or preventive maintenance efforts made in order to avoid losses of availability to a large extent also imply at least a preservation or even higher levels of safety. Thus, economic efficiency and safety are closely correlated. Public opinion is very sensible as soon as the high level of plant safety seems to be touched by economic pressure. But realizing that German NPP are endowed with mature design and safety features, improvements of safety standards can only marginally be increased by further technical optimizations. Therefore plant management, man-machine-interface and the individual behaviour of the employees are targets for improvement of nuclear safety and economic efficiency by increasing the efficiency of processes. An even more efficient use of scarce funds and a tolerable political environment should allow the safety level of NPP to be upheld, and safety culture could be maintained and even be improved. (author)

  15. Linear response theory for magnetic Schrodinger operators in disordered media

    CERN Document Server

    Bouclet, J M; Klein, A; Schenker, J

    2004-01-01

    We justify the linear response theory for an ergodic Schrodinger operator with magnetic field within the non-interacting particle approximation, and derive a Kubo formula for the electric conductivity tensor. To achieve that, we construct suitable normed spaces of measurable covariant operators where the Liouville equation can be solved uniquely. If the Fermi level falls into a region of localization, we recover the well-known Kubo-Streda formula for the quantum Hall conductivity at zero temperature.

  16. Operationally Responsive Spacelift: Supporting a Seven-Day Launch Schedule

    Science.gov (United States)

    2013-06-01

    release; distribution is unlimited 12b. DISTRIBUTION CODE A 13. ABSTRACT (maximum 200 words) In 2001, the Air Force issued AFSPC 001-01...14. SUBJECT TERMS Operationally Responsive Space 15. NUMBER OF PAGES 81 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT...Joe Nemeth , both government servants at Vandenberg AFB, for being willing to dig up range operations documents that were not available on the

  17. 19 CFR 146.4 - Operator responsibility and supervision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Operator responsibility and supervision. 146.4 Section 146.4 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... exercise, and may take into account the degree of supervision exercised by the zone user having physical...

  18. Response Times of Operators in a Control Room

    DEFF Research Database (Denmark)

    Platz, O.; Rasmussen, Jens; Skanborg, Preben Zacho

    A statistical analysis was made of operator response times recorded in the control room of a research reactor during the years 1972-1974. A homogeneity test revealed that the data consist of a mixture of populations. A small but statistically significant difference is found between day and night...

  19. Air Quality and Health Benefits of China's Recent Stringent Environmental Policy

    Science.gov (United States)

    Zheng, Y.; Xue, T.; Zhang, Q.; Geng, G.; He, K.

    2016-12-01

    Aggressive emission control measures were taken by China's central and local governments after the promulgation of the "Air Pollution Prevention and Control Action Plan" in 2013. We evaluated the air quality and health benefits of this ever most stringent air pollution control policy during 2013-2015 by utilizing a two-stage data fusion model and newly-developed cause-specific integrated exposure-response functions (IER) developed for the Global Burden of Disease (GBD). The two-stage data fusion model predicts spatiotemporal continuous PM2.5 (particulate matter with aerodynamic diameter less than 2.5 µm) concentrations by integrating satellite-derived aerosol optical depth (AOD) measurements, PM2.5 concentrations from measurement and air quality model, and other ancillary information. During the years of analysis, PM2.5 concentration dropped significantly on national average and over heavily polluted regions as identified by Mann-Kendall analysis. The national PM2.5-attributable mortality decreased by 72.8 (95% CI: 59.4, 85.2) thousand (6%) from 1.23 (95% CI: 1.06, 1.39) million in 2013 to 1.15 (95% CI: 0.98, 1.31) million in 2015 due to considerable reduction (i.e. 18%) of population-weighted PM2.5 from 61.4 to 50.5 µg/m3. Meteorological variations between 2013 and 2015 were estimated to raise the PM2.5 levels by 0.24 µg/m3 and national mortality by 2.1 (95% CI: 1.6, 2.6) thousand through sensitivity tests, which implies the dominant role of anthropogenic impacts on PM2.5 abatement and attributable mortality reduction. Our study affirms the effectiveness of China's recent air quality policy, however, due to the possible supralinear shape of C-R functions, health benefits induced by air quality improvement in these years are limited. We therefore appeal for continuous implementation of current policies and further stringent measures from both air quality improvement and public health protection perspectives.

  20. The use of UAS in disaster response operations

    Science.gov (United States)

    Gkotsis, I.; Eftychidis, G.; Kolios, P.

    2017-09-01

    The use of UAS by the emergency services has been received with great interest since UAS provide both informant and helper support in a flexible, effective and efficient manner. This is due to the fact that, UAS can strengthen the operational capabilities related to: prevention (e.g., patrolling of large and hard to reach areas), early detection (e.g., mapping of vulnerable elements), disaster preparedness (e.g., incident inspection), response (mapping damages, search and rescue, provide an ad hoc communication network, monitor evacuation, etc). Through PREDICATE, a project concerning civilian use of drones, the necessary methodologies to guide the selection and operational use of UAS in emergencies, are developed. To guide UAS selection, the project performed a detailed needs assessment in cooperation with civil protection and law enforcement agencies. As a result of this assessment, currently available technologies and market solutions were reviewed leading to the development of an online user-friendly tool to support selection of UAS based on operational requirements. To guide the use of UAS, PREDICATE developed an intelligent path planning toolkit to automate the operation of UAS and ease their use for the various civil protection operations. By employing the aforementioned tools, emergency services will be able to better understand how to select and make use of UAS for watch-keeping and patrolling of their own disaster-prone Regions of Interest. The research, innovation and applicability behind both these tools is detailed in this work.

  1. Talisman Energy Inc : corporate social responsibility report 2001 : Sudan operations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    Talisman Energy Inc. is a large independent Canadian oil and gas producer with operations worldwide, including operations in Sudan, Malaysia, Trinidad and Colombia. This report includes a discussion on seismic exploration in the Acevedo block in Colombia, but most of the report focuses on operations in Sudan because that is the primary concern of many stakeholders, particularly the impact of the long-running civil war in that country and the way in which oil revenues will be used. The report describes Talisman Energy's compliance with the International Code of Ethics for Canadian Business which Talisman adopted in December 1999. The report evaluates Talisman's progress towards achieving objectives in the areas of human rights, community participation, employee rights, ethical business conduct, health, safety and the environment. Talisman will continue to advocate peace and the fair distribution of oil revenues. It was noted that the funding provided by the Sudan oil project consortium Greater Nile Petroleum Operating Company (GNPOC) for community development was increased for 2002. Talisman and GNPOC funding helps in community development initiatives such as the provision of water wells, health clinics and schools in Sudan. PricewaterhouseCoopers (PwC) was asked by Talisman to gather comments on the company's operations in Sudan from a range of stakeholder groups. This report presents audit statements by PwC regarding Talisman's social responsibility. The report also included an independent opinion regarding the challenge of facing ethical dilemmas in business. tabs., figs.

  2. Initial operations in local nuclear emergency response headquarter

    International Nuclear Information System (INIS)

    2012-06-01

    As a result of the Fukushima nuclear accident due to the Great East Japan Earthquake and the tsunami that occurred thereafter, local nuclear emergency response headquarters (local headquarters) was set up at off-site center (OFC). However, several obstacles such as the collapse of means of communication resulting from severed communication lines, food and fuel shortage resulting from stagnant physical distribution, and increasing radiation dose around the center significantly restricted originally intended operation of local headquarters. In such severe situation, the personnel gathered at the OFC from the government, local public bodies and electric companies from March 11 to 15 acted without sufficient food, sleep or rest and did all they could against successively occurring unexpected challenges by using limited means of communication. However, issues requiring further consideration were activities of each functional group, location of OFC and the functions of equipment, machines and materials and reflecting the consideration results into future protective measures and revision of the manual for nuclear emergency response were greatly important. This report described investigated results on initial operations in local headquarters such as situation of activities conducted by local headquarters and operations at functional groups. (T. Tanaka)

  3. The Race Toward Becoming Operationally Responsive in Space

    Science.gov (United States)

    Nagy, J.; Hernandez, V.; Strunce, R.

    The US Air Force Research Laboratory (AFRL) is currently supporting the joint Operationally Responsive Space (ORS) program with two aggressive research space programs. The goal of the ORS program is to improve the responsiveness of space capabilities to meet national security requirements. ORS systems aim to provide operational space capabilities as well as flexibility and responsiveness to the theater that do not exist today. ORS communication, navigation, and Intelligence, Surveillance and Reconnaissance (ISR) satellites are being designed to rapidly meet near term space needs of in-theater tactical forces by supporting contingency operations, such as increased communication bandwidth, and ISR imagery over the theater for a limited period to support air, ground, and naval force missions. This paper will discuss how AFRL/RHA is supporting the ORS effort and describe the hardware and software being developed with a particular focus on the Satellite Design Tool for plug-n-play satellites (SDT). AFRLs Space Vehicles Directorate together with the Scientific Simulation, Inc. was the first to create the Plug-and-play (PnP) satellite design for rapid construction through modular components that encompass the structural panels, as well as the guidance and health/status components. Expansion of the PnP technology is currently being led by AFRL's Human Effectiveness Directorate and Star Technologies Corp. by pushing the boundaries of mobile hardware and software technology through the development of the teams "Training and Tactical ORS Operations (TATOO) Laboratory located in Great Falls, VA. The TATOO Laboratory provides a computer-based simulation environment directed at improving Warfighters space capability responsiveness by delivering the means to create and exercise methods of in-theater tactical satellite tasking for and by the Warfighter. In an effort to further support the evolution of ORS technologies with Warfighters involvement, Star recently started

  4. The limitations in implementing and operating a rapid response system.

    Science.gov (United States)

    Subramaniam, A; Botha, J; Tiruvoipati, R

    2016-10-01

    Despite the widespread introduction of rapid response systems (RRS)/medical emergency teams (MET), there is still controversy regarding how effective they are. While there are some observational studies showing improved outcomes with RRS, there are no data from randomised controlled trials to support the effectiveness. Nevertheless, the MET system has become a standard of care in many healthcare organisations. In this review, we present an overview of the limitations in implementing and operating a RRS in modern healthcare. © 2016 Royal Australasian College of Physicians.

  5. Enhancing nuclear emergency response through international co-operation

    International Nuclear Information System (INIS)

    Ugletveit, F.; Aaltonen, H.

    2003-01-01

    perspective however, there are probably substantial resources available for response to nuclear or radiological emergencies. The problem is that during an emergency, these resources are not where they are needed. Most resources are under authority control in the respective countries, but if all countries would commit themselves to contribute to such assistance arrangements between countries and invoke all resources available and efficiently co-ordinate and route them to where they are mostly needed, the international community and individual States would achieve a better and more efficient response to emergencies. Resources could in this respect be everything that is needed to respond to an emergency, e.g. equipment, expertise, assessment capabilities or other services. These arrangements should be global arrangements as bi-lateral or regional arrangements are only adequate for some scenarios. The Convention an Early Notification of a Nuclear Accident and the Convention an Assistance in Case of a Nuclear Accident or Radiological Emergency established in 1986 are at present acceded by approx. 85 IAEA Member States. These conventions constitute the framework of international co-operation on response to nuclear and radiological emergencies between States and describe the obligations and mechanisms of international notification and assistance. The conventions recognize the need for a co-ordinating and facilitating body in this co-operation and the IAEA has been given this role. The conventions an Assistance and Early Notification provide a good framework for achieving international co-operation an nuclear emergency response. It has however been recognised that the implementation of these conventions needs to be improved. This is the responsibility of acceding states. To efficiently share information between many states, it is necessary to establish a standard international communication platform for information exchange with a communication strategy and standardization

  6. THE DEVELOPMENT OF LEGAL RESPONSIBILITY FOR A SOCIALLY RESPONSIBLE BEHAVIOR FOR BUSINESS OPERATORS IN ROMANIA, MEMBER STATE OF EUROPEAN UNION

    Directory of Open Access Journals (Sweden)

    Laura MURESAN

    2016-03-01

    Full Text Available Legal responsibility represents an important component of social responsibility, together with ethical responsibility, ecological responsibility, economical responsibility and philanthropic responsibility. The integration of social responsibility into the activity of business operators in the Member states of European Union is pursued at European Union level. The article analyses the opinion of the Brasov city citizens, in the framework of a marketing research performed in 2015, as regards the possibility that legal instruments should influence a socially responsible behavior for public or private business operators. The aspects analysed for business operators in Romania can represent a model for other European Union states as well.

  7. Soldier-Warfighter Operationally Responsive Deployer for Space

    Science.gov (United States)

    Davis, Benny; Huebner, Larry; Kuhns, Richard

    2015-01-01

    The Soldier-Warfighter Operationally Responsive Deployer for Space (SWORDS) project was a joint project between the U.S. Army Space & Missile Defense Command (SMDC) and NASA. The effort, lead by SMDC, was intended to develop a three-stage liquid bipropellant (liquid oxygen/liquid methane), pressure-fed launch vehicle capable of inserting a payload of at least 25 kg to a 750-km circular orbit. The vehicle design was driven by low cost instead of high performance. SWORDS leveraged commercial industry standards to utilize standard hardware and technologies over customized unique aerospace designs. SWORDS identified broadly based global industries that have achieved adequate levels of quality control and reliability in their products and then designed around their expertise and business motivations.

  8. Rapid species responses to changes in climate require stringent climate protection targets

    NARCIS (Netherlands)

    Vliet, van A.J.H.; Leemans, R.

    2006-01-01

    The Avoiding Dangerous Climate Change book consolidates the scientific findings of the Exeter conference and gives an account of the most recent developments on critical thresholds and key vulnerabilities of the climate system, impacts on human and natural systems, emission pathways and

  9. THE DEVELOPMENT OF LEGAL RESPONSIBILITY FOR A SOCIALLY RESPONSIBLE BEHAVIOR FOR BUSINESS OPERATORS IN ROMANIA, MEMBER STATE OF EUROPEAN UNION

    OpenAIRE

    Laura MURESAN

    2016-01-01

    Legal responsibility represents an important component of social responsibility, together with ethical responsibility, ecological responsibility, economical responsibility and philanthropic responsibility. The integration of social responsibility into the activity of business operators in the Member states of European Union is pursued at European Union level. The article analyses the opinion of the Brasov city citizens, in the framework of a marketing research performed in 2015, as regards th...

  10. Operator/regulator interface: Organizational structure and responsibilities

    International Nuclear Information System (INIS)

    Wiebe, J.S.

    1997-01-01

    In the context of promotion of safety culture for the nuclear power plants the following aspects are briefly described: operator/regulator interface regulatory organization; policy making body; operating organization; regulatory interface

  11. Response modification for enhanced operation and safety of bridges.

    Science.gov (United States)

    2011-08-01

    This report shows that safe extension of the service life of existing bridge structures is possible through bridge : health monitoring and structural response modification. To understand bridge health monitoring and structural : response modification...

  12. The effect of dietary fatty acids on post-operative inflammatory response in a porcine model

    DEFF Research Database (Denmark)

    Langerhuus, Sine Nygaard; Jensen, Karin Hjelholt; Tønnesen, Else Kirstine

    2012-01-01

    ), sunflower oil (SO, n 28), or animal fat (AF, n 28) was evaluated with respect to post-operative responses in inflammatory markers in a porcine model on aortic vascular prosthetic graft infection. In the early post-operative period (0 ...-operative response in a number of inflammatory markers was affected by FO, and this was most apparent compared with SO....

  13. Cognitive modeling and dynamic probabilistic simulation of operating crew response to complex system accidents. Part 4: IDAC causal model of operator problem-solving response

    International Nuclear Information System (INIS)

    Chang, Y.H.J.; Mosleh, A.

    2007-01-01

    This is the fourth in a series of five papers describing the Information, Decision, and Action in Crew context (IDAC) operator response model for human reliability analysis. An example application of this modeling technique is also discussed in this series. The model has been developed to probabilistically predicts the responses of a nuclear power plant control room operating crew in accident conditions. The operator response spectrum includes cognitive, emotional, and physical activities during the course of an accident. This paper assesses the effects of the performance-influencing factors (PIFs) affecting the operators' problem-solving responses including information pre-processing (I), diagnosis and decision making (D), and action execution (A). Literature support and justifications are provided for the assessment on the influences of PIFs

  14. Waste management from reprocessing: a stringent regulatory requirements for high quality conditioned residues

    International Nuclear Information System (INIS)

    Bordier, J. C.; Greneche, D.; Devezeaux, J. G.; Dalcorso, J.

    2000-01-01

    Nuclear waste production and management in France is governed by safety requirements imposed to all operators. French nuclear safety relies on two basic principles: · Responsibility of the nuclear operator, which expands to waste generated, · Safety basic objectives issued by national Safety Authority. For a long time the regulatory framework for waste production and management has been satisfactorily applied and has benefited to each actor of the process. LLW/MLW and HLW nuclear waste are currently conditioned in safe matrices or packages either likely to be disposed in surface repositories or designed with the intention to be disposed underground according to their radioactive content. France is looking into the case of VLLW and has already carried out a design for future disposal, the design being in the pipe. Other types of waste (i. e. radium bearing waste, graphite, and tritium content waste) are also considered in the whole framework of French waste management. (author)

  15. NRC/FEMA operational response procedures for response to a commercial nuclear reactor accident

    International Nuclear Information System (INIS)

    1983-11-01

    Procedures have been developed by the US Nuclear Regulatory Commission (NRC) and the Federal Emergency Management Agency (FEMA) which provide the response teams of both agencies with the steps to be taken in responding to an emergency at a commercial nuclear power plant. The emphasis of these procedures is mainly on the interface between NRC and FEMA at their respective Headquarters and Regional Offices and at the various sites at which such an emergency could occur. Detailed procedures are presented that cover for both agencies, notification schemes and manner of activation, organizations at Headquaters and the site, interface procedures, coordination of onsite and offsite operations, the role of the Senior FEMA Official, and the cooperative efforts of each agency's public information staff

  16. NRC/FEMA operational response procedures for response to a commercial nuclear reactor accident. Revision 1

    International Nuclear Information System (INIS)

    1985-02-01

    Procedures have been developed by the US Nuclear Regulatory Commission (NRC) and the Federal Emergency Management Agency (FEMA) which provide the response teams of both agencies with the steps to be taken in responding to an emergency at a commercial nuclear power plant. The emphasis of these procedures is mainly on the interface between NRC and FEMA at their respective Headquarters and Regional Offices and at the various sites at which such an emergency could occur. Detailed procedures are presented that cover for both agencies, notification schemes and manner of activation, organizations at Headquarters and the site, interface procedures, coordination of onsite and offsite operations, the role of the Senior FEMA Official, and the cooperative efforts of each agency's public information staff

  17. The role of control in allocating international responsibility in collaborative military operations

    NARCIS (Netherlands)

    Boutin, B.L.

    2015-01-01

    This thesis addresses the responsibility of States and international organizations for violations of international law committed during collaborative military operations. More specifically, it enquires into the role of control for allocating responsibility between States and international

  18. Human operant learning under concurrent reinforcement of response variability

    NARCIS (Netherlands)

    Maes, J.H.R.; Goot, M.H. van der

    2006-01-01

    This study asked whether the concurrent reinforcement of behavioral variability facilitates learning to emit a difficult target response. Sixty students repeatedly pressed sequences of keys, with an originally infrequently occurring target sequence consistently being followed by positive feedback.

  19. Talisman Energy Inc : corporate social responsibility report 2000 : Sudan operations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-04-01

    Talisman Energy Inc., the largest independent Canadian oil and gas producer with operations worldwide, owns a subsidiary Talisman (Greater Nile) B.V., which is in turn a 25 per cent owner in the Greater Nile Petroleum Operating Company (GNPOC) whose share of oil production accounted for 11 per cent of Talisman's worldwide production in 2000. GNPOC operates three exploration and two development blocks encompassing 12,200,000 acres of land in Sudan. Production began in 1999 and is currently at 200,000 barrels per day. This report describes Talisman Energy's operations in Sudan and measures compliance with the International Code of Ethics for Canadian Business that Talisman adopted in December 1999. The report evaluates Talisman's progress towards achieving objectives in the areas of human rights, community participation, employee rights, ethical business conduct, health, safety and the environment. In addition, Talisman will continue to advocate peace and the fair distribution of oil revenues. Talisman's community development initiatives include the provision of water wells, health clinics and schools in Sudan. tabs., figs.

  20. Dual Regulation of Bacillus subtilis kinB Gene Encoding a Sporulation Trigger by SinR through Transcription Repression and Positive Stringent Transcription Control

    Directory of Open Access Journals (Sweden)

    Yasutaro Fujita

    2017-12-01

    Full Text Available It is known that transcription of kinB encoding a trigger for Bacillus subtilis sporulation is under repression by SinR, a master repressor of biofilm formation, and under positive stringent transcription control depending on the adenine species at the transcription initiation nucleotide (nt. Deletion and base substitution analyses of the kinB promoter (PkinB region using lacZ fusions indicated that either a 5-nt deletion (Δ5, nt -61/-57, +1 is the transcription initiation nt or the substitution of G at nt -45 with A (G-45A relieved kinB repression. Thus, we found a pair of SinR-binding consensus sequences (GTTCTYT; Y is T or C in an inverted orientation (SinR-1 between nt -57/-42, which is most likely a SinR-binding site for kinB repression. This relief from SinR repression likely requires SinI, an antagonist of SinR. Surprisingly, we found that SinR is essential for positive stringent transcription control of PkinB. Electrophoretic mobility shift assay (EMSA analysis indicated that SinR bound not only to SinR-1 but also to SinR-2 (nt -29/-8 consisting of another pair of SinR consensus sequences in a tandem repeat arrangement; the two sequences partially overlap the ‘-35’ and ‘-10’ regions of PkinB. Introduction of base substitutions (T-27C C-26T in the upstream consensus sequence of SinR-2 affected positive stringent transcription control of PkinB, suggesting that SinR binding to SinR-2 likely causes this positive control. EMSA also implied that RNA polymerase and SinR are possibly bound together to SinR-2 to form a transcription initiation complex for kinB transcription. Thus, it was suggested in this work that derepression of kinB from SinR repression by SinI induced by Spo0A∼P and occurrence of SinR-dependent positive stringent transcription control of kinB might induce effective sporulation cooperatively, implying an intimate interplay by stringent response, sporulation, and biofilm formation.

  1. Request and Requirements Development Process for Operationally Responsive Space Capabilities

    Science.gov (United States)

    2013-03-01

    Army Forces Strategic Command (USASMDC/ARSTRAT) Joint Capability Technology Demonstrations (JCTDs) nanosatellite (small satellite) initiative. Space...and Missile Defense Command Nanosatellite Project (SNaP) is a USASMDC/ARSTRAT, Technical Center’s JCTD. The mission of SNaP is to launch and...operate three communications nanosatellites into low earth orbit to provide United States Southern Command (USSOUTHCOM) with satellite communications and

  2. Operational Art and the Commander’s Emergency Response Program

    Science.gov (United States)

    2010-06-08

    faced with [a] lack of results, to do more of the same.” 54 Social psychologist Kurt Lewin provides a three-stage model for planned change . 55 The...Chiefs of Staff, Joint Operations, final coordination, Joint Publication (JP) 3-0 (Washington, DC: CJCS, 17 September 2006 incorporating Change 1...clear objectives, and measures of effectiveness. Measures of effectiveness should be “used to assess changes in system behavior, capability, or

  3. Response trees and expert systems for nuclear reactor operations

    International Nuclear Information System (INIS)

    Nelson, W.R.

    1984-02-01

    The United States Nuclear Regulatory Commission is sponsoring a project performed by EG and G Idaho, Inc., at the Idaho National Engineering Laboratory (INEL) to evaluate different display concepts for use in nuclear reactor control rooms. Included in this project is the evaluation of the response tree computer based decision aid and its associated displays. This report serves as an overview of the response tree methodology and how it has been implemented as a computer based decision aid utilizing color graphic displays. A qualitative assessment of the applicability of the response tree aid in the reactor control room is also made. Experience gained in evaluating the response tree aid is generalized to address a larger category of computer aids, those known as knowledge based expert systems. General characteristics of expert systems are discussed, as well as examples of their application in other domains. A survey of ongoing work on expert systems in the nuclear industry is presented, and an assessment of their potential applicability is made. Finally, recommendations for the design and evaluation of computer based decision aids are presented

  4. Stability of abstract nonlinear nonautonomous differential-delay equations with unbounded history-responsive operators

    Science.gov (United States)

    Gil', M. I.

    2005-08-01

    We consider a class of nonautonomous functional-differential equations in a Banach space with unbounded nonlinear history-responsive operators, which have the local Lipshitz property. Conditions for the boundedness of solutions, Lyapunov stability, absolute stability and input-output one are established. Our approach is based on a combined usage of properties of sectorial operators and spectral properties of commuting operators.

  5. Operational Energy/Operational Effectiveness Investigation for Scalable Marine Expeditionary Brigade Forces in Contingency Response Scenarios

    Science.gov (United States)

    2014-12-01

    BACKGROUND In today’s austere fiscal environment the United States Marine Corps (USMC) is motivated to return balance to the expeditionary strength ...K. Lauren. 2007. “MANA (Map Aware Non-Uniform Automata) Version 4 User Manual.” Auckland , New Zealand: Operations Analysis Section, Defense

  6. Emergency response mobile robot for operations in combustible atmospheres

    Science.gov (United States)

    Stone, Henry W. (Inventor); Ohm, Timothy R. (Inventor)

    1995-01-01

    A mobile, self-powered, self-contained, and remote-controlled robot is presented. The robot is capable of safely operating in a combustible atmosphere and providing information about the atmosphere to the operator. The robot includes non-sparking and non-arcing electro-mechanical and electronic components designed to prevent the robot from igniting the combustible atmosphere. The robot also includes positively pressurized enclosures that house the electromechanical and electronic components of the robot and prevent intrusion of the combustible atmosphere into the enclosures. The enclosures are interconnected such that a pressurized gas injected into any one of the enclosures is routed to all the other enclosures through the interconnections. It is preferred that one or more sealed internal channels through structures intervening between the enclosures be employed. Pressure transducers for detecting if the pressure within the enclosures falls below a predetermined level are included. The robot also has a sensing device for determining the types of combustible substances in the surrounding atmosphere, as well as the concentrations of each type of substance relative to a pre-determined lower explosive limit (LEL). In addition, the sensing device can determine the percent level of oxygen present in the surrounding atmosphere.

  7. ALARM STRATEGY AND COMPLEXITY: PREDICTIONS OF OPERATOR RESPONSE

    Energy Technology Data Exchange (ETDEWEB)

    Austin Ragsdale; Roger Lew; Brian Dyre; Ronald Boring; David Gertman

    2012-07-01

    Decision support for operators is not new, and much has been written regarding the potential usefulness of digital support systems and alarm filtering strategies. However, determining the appropriate characteristics of decision support tools is difficult, especially when alarms can vary in the manner which diagnostic information is formulated and displayed and when event scenario types are complex and numerous. When first reviewed, the advantages or disadvantages of a particular alarm approach may not be apparent to the designer or analyst. The present research focuses on the review of two particular alarm strategies, binary alarm type (BAT) and likelihood alarm type (LAT), and reviews their influence upon accuracy, bias, and trust for tasks performed at a computer workstation capable of replicating a series of control-room-like alarms. The findings are discussed in terms of the of the performance advantages of likelihood alarm technology and related research as an aid to the alarm design process.

  8. Real Time Optimal Control of Supercapacitor Operation for Frequency Response

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Yusheng; Panwar, Mayank; Mohanpurkar, Manish; Hovsapian, Rob

    2016-07-01

    Supercapacitors are gaining wider applications in power systems due to fast dynamic response. Utilizing supercapacitors by means of power electronics interfaces for power compensation is a proven effective technique. For applications such as requency restoration if the cost of supercapacitors maintenance as well as the energy loss on the power electronics interfaces are addressed. It is infeasible to use traditional optimization control methods to mitigate the impacts of frequent cycling. This paper proposes a Front End Controller (FEC) using Generalized Predictive Control featuring real time receding optimization. The optimization constraints are based on cost and thermal management to enhance to the utilization efficiency of supercapacitors. A rigorous mathematical derivation is conducted and test results acquired from Digital Real Time Simulator are provided to demonstrate effectiveness.

  9. Does dishonesty really invite third-party punishment? Results of a more stringent test.

    Science.gov (United States)

    Konishi, Naoki; Ohtsubo, Yohsuke

    2015-05-01

    Many experiments have demonstrated that people are willing to incur cost to punish norm violators even when they are not directly harmed by the violation. Such altruistic third-party punishment is often considered an evolutionary underpinning of large-scale human cooperation. However, some scholars argue that previously demonstrated altruistic third-party punishment against fairness-norm violations may be an experimental artefact. For example, envy-driven retaliatory behaviour (i.e. spite) towards better-off unfair game players may be misidentified as altruistic punishment. Indeed, a recent experiment demonstrated that participants ceased to inflict third-party punishment against an unfair player once a series of key methodological problems were systematically controlled for. Noticing that a previous finding regarding apparently altruistic third-party punishment against honesty-norm violations may have been subject to methodological issues, we used a different and what we consider to be a more sound design to evaluate these findings. Third-party punishment against dishonest players withstood this more stringent test. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  10. Emission reductions in transition economies: A result of output contraction or more stringent environmental policy?

    Energy Technology Data Exchange (ETDEWEB)

    Zugravu, N.; Millock, K. [University Paris 1 Pantheon-Sorbonne (France); Duchene, G. [University Paris 12, Creteil (France)

    2007-07-01

    Countries in Central and Eastern Europe significantly reduced their CO{sub 2} emissions between 1996 and 2001. Was this emission reduction just the fortuitous result of the major economic transformation undergone by those countries in the transition away from a centralized plan economy? Or is the emission reduction rather a result of more stringent environmental policy? The objective of the article is to answer this question through a model of the relation between environmental quality and enforcement, on the one hand, and environmental quality and economic growth, on the other hand. The authors develop structural equations for the demand (emissions) and supply (environmental stringency) of pollution. The supply equation takes into account the institutional quality of the country (control of corruption and political stability) as well as consumer preferences for environmental quality, as proxied by per capita revenue and unemployment. The system is estimated by three stage least squares on a sample of three groups of countries for comparative analysis: Central and Eastern European countries, Western European countries, and emerging economies. The results indicate that, all else equal, the scale effect on its own would have increased industrial CO{sub 2} emissions in the Central and Eastern European countries in the sample by 44.6% between 1996 and 2001. The composition effect accounted for a corresponding reduction in emissions by 16%. The technique effect had the largest marginal impact, corresponding to a 37.4% reduction in emissions.

  11. Bulk development and stringent selection of microsatellite markers in the western flower thrips Frankliniella occidentalis.

    Science.gov (United States)

    Cao, Li-Jun; Li, Ze-Min; Wang, Ze-Hua; Zhu, Liang; Gong, Ya-Jun; Chen, Min; Wei, Shu-Jun

    2016-05-20

    Recent improvements in next-generation sequencing technologies have enabled investigation of microsatellites on a genome-wide scale. Faced with a huge amount of candidates, the use of appropriate marker selection criteria is crucial. Here, we used the western flower thrips Frankliniella occidentalis for an empirical microsatellite survey and validation; 132,251 candidate microsatellites were identified, 92,102 of which were perfect. Dinucleotides were the most abundant category, while (AG)n was the most abundant motif. Sixty primer pairs were designed and validated in two natural populations, of which 30 loci were polymorphic, stable, and repeatable, but not all in Hardy-Weinberg equilibrium (HWE) and linkage equilibrium. Four marker panels were constructed to understand effect of marker selection on population genetic analyses: (i) only accept loci with single nucleotide insertions (SNI); (ii) only accept the most polymorphic loci (MP); (iii) only accept loci that did not deviate from HWE, did not show SNIs, and had unambiguous peaks (SS) and (iv) all developed markers (ALL). Although the MP panel resulted in microsatellites of highest genetic diversity followed by the SNI, the SS performed best in individual assignment. Our study proposes stringent criteria for selection of microsatellites from a large-scale number of genomic candidates for population genetic studies.

  12. Operative skill: quantifying surgeon's response to tissue properties.

    Science.gov (United States)

    D'Angelo, Anne-Lise D; Rutherford, Drew N; Ray, Rebecca D; Mason, Andrea; Pugh, Carla M

    2015-10-01

    The aim of this study was to investigate how tissue characteristics influence psychomotor planning and performance during a suturing task. Our hypothesis was that participants would alter their technique based on tissue type with each subsequent stitch placed while suturing. Surgical attendings (n = 6), residents (n = 4), and medical students (n = 5) performed three interrupted sutures on different simulated materials as follows: foam (dense connective tissue), rubber balloons (artery), and tissue paper (friable tissue). An optical motion tracking system captured performance data from participants' bilateral hand movements. Path length and suture time were segmented by each individual stitch placed to investigate changes to psychomotor performance with subsequent stitch placements. Repeated measures analysis of variance was used to evaluate for main effects of stitch order on path length and suture time and interactions between stitch order, material, and experience. When participants sutured the tissue paper, they changed their procedure time (F(4,44) = 5.14, P = 0.017) and path length (F(4,44) = 4.64, P = 0.003) in a linear fashion with the first stitch on the tissue paper having the longest procedure time and path length. Participants did not change their path lengths and procedure times when placing subsequent stitches in the foam (P = 0.910) and balloon materials (P = 0.769). This study demonstrates quantifiable real-time adaptation by participants to material characteristics during a suturing task. Participants improved their motion-based performance with each subsequent stitch placement indicating changes in psychomotor planning or performance. This adaptation did not occur with the less difficult tasks. Motion capture technology is a promising method for investigating surgical performance and how surgeons adapt to operative complexity. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Effectiveness Analysis of a Part-Time Rapid Response System During Operation Versus Nonoperation.

    Science.gov (United States)

    Kim, Youlim; Lee, Dong Seon; Min, Hyunju; Choi, Yun Young; Lee, Eun Young; Song, Inae; Park, Jong Sun; Cho, Young-Jae; Jo, You Hwan; Yoon, Ho Il; Lee, Jae Ho; Lee, Choon-Taek; Do, Sang Hwan; Lee, Yeon Joo

    2017-06-01

    To evaluate the effect of a part-time rapid response system on the occurrence rate of cardiopulmonary arrest by comparing the times of rapid response system operation versus nonoperation. Retrospective cohort study. A 1,360-bed tertiary care hospital. Adult patients admitted to the general ward were screened. Data were collected over 36 months from rapid response system implementation (October 2012 to September 2015) and more than 45 months before rapid response system implementation (January 2009 to September 2012). None. The rapid response system operates from 7 AM to 10 PM on weekdays and from 7 AM to 12 PM on Saturdays. Primary outcomes were the difference of cardiopulmonary arrest incidence between pre-rapid response system and post-rapid response system periods and whether the rapid response system operating time affects the cardiopulmonary arrest incidence. The overall cardiopulmonary arrest incidence (per 1,000 admissions) was 1.43. Although the number of admissions per month and case-mix index were increased (3,555.18 vs 4,564.72, p rapid response system (1.60 vs 1.23; p = 0.021), and mortality (%) was unchanged (1.38 vs 1.33; p = 0.322). After rapid response system implementation, the cardiopulmonary arrest incidence significantly decreased by 40% during rapid response system operating times (0.82 vs 0.49/1,000 admissions; p = 0.001) but remained similar during rapid response system nonoperating times (0.77 vs 0.73/1,000 admissions; p = 0.729). The implementation of a part-time rapid response system reduced the cardiopulmonary arrest incidence based on the reduction of cardiopulmonary arrest during rapid response system operating times. Further analysis of the cost effectiveness of part-time rapid response system is needed.

  14. PBO Southwest Region: Baja Earthquake Response and Network Operations

    Science.gov (United States)

    Walls, C. P.; Basset, A.; Mann, D.; Lawrence, S.; Jarvis, C.; Feaux, K.; Jackson, M. E.

    2011-12-01

    The SW region of the Plate Boundary Observatory consists of 455 continuously operating GPS stations located principally along the transform system of the San Andreas fault and Eastern California Shear Zone. In the past year network uptime exceeded an average of 97% with greater than 99% data acquisition. Communications range from CDMA modem (307), radio (92), Vsat (30), DSL/T1/other (25) to manual downloads (1). Sixty-three stations stream 1 Hz data over the VRS3Net typically with theft) to moderate vandalism (solar panel stolen) with one total loss of receiver and communications gear. Security was enhanced at these sites through fencing and more secure station configurations. In the past 12 months, 4 new stations were installed to replace removed stations or to augment the network at strategic locations. Following the M7.2 El Mayor-Cucapah earthquake CGPS station P796, a deep-drilled braced monument, was constructed in San Luis, AZ along the border within 5 weeks of the event. In addition, UNAVCO participated in a successful University of Arizona-led RAPID proposal for the installation of six continuous GPS stations for post-seismic observations. Six stations are installed and telemetered through a UNAM relay at the Sierra San Pedro Martir. Four of these stations have Vaisala WXT520 meteorological sensors. An additional site in the Sierra Cucapah (PTAX) that was built by CICESE, an Associate UNAVCO Member institution in Mexico, and Caltech has been integrated into PBO dataflow. The stations will be maintained as part of the PBO network in coordination with CICESE. UNAVCO is working with NOAA to upgrade PBO stations with WXT520 meteorological sensors and communications systems capable of streaming real-time GPS and met data. The real-time GPS and meteorological sensor data streaming support watershed and flood analyses for regional early-warning systems related to NOAA's work with California Department of Water Resources. Currently 19 stations are online and

  15. Circulatory Responses to Operative Stress in Females with Gestosis

    Directory of Open Access Journals (Sweden)

    I. V. Mikhno

    2007-01-01

    Full Text Available Objective: to study the specific features of hemodynamic responses in females with gestosis in the perioperative period; to evaluate the impact of intensive care on the basis of co-administration of dalargin, dexamethasone, pen-toxifylline, and reamberin.Materials and methods. A Diamant KM-AP-01 rheograph (Saint Petersburg was used to study hemodynamic parameters in 142 patients in whom surgical delivery was made under spinal anesthesia. A control group comprised 30 patients with uncomplicated pregnancy; Group 1 included 26 females with moderate gestosis; Group 2 consisted of 27 females with moderate gestosis who received the developed intensive care regimen; Group 3 comprised 29 females with severe gestosis; Group 4 included 30 females to whom the developed intensive care regimen was applied on the basis of the concurrent use of dalargin, dexamethasone, pentoxifylline, and reamberin.Results: A neurogenic mechanism prevails in females with moderate gestosis. The decreased baseline cardiac index is mostly due to a high postload. Surgical stress does not deteriorate postoperative circulatory parameters, which suggests that females with moderate gestosis have adequate capacities for self-regulation. As gestosis progresses to a severe degree, a role of humoral mechanisms increases in the maintenance of arteriolar spasm. Arteriolar spasm and hypokinetic hemodynamics are retained within 5 postoperative days, which is indicative of the inadequacy of self-regulation and compensatory mechanisms in overcoming two stressors: severe gestosis and surgical aggression.Conclusion: the intensive care regimen developed on the basis of combined use of dalargin, dexamethasone, pentoxifylline, and reamberin favors a more intensive (the promptest normalization of circulatory parameters after surgical delivery in females with moderate and severe gestosis. 

  16. Adaptation to fluctuating temperatures in an RNA virus is driven by the most stringent selective pressure.

    Directory of Open Access Journals (Sweden)

    María Arribas

    Full Text Available The frequency of change in the selective pressures is one of the main factors driving evolution. It is generally accepted that constant environments select specialist organisms whereas changing environments favour generalists. The particular outcome achieved in either case also depends on the relative strength of the selective pressures and on the fitness costs of mutations across environments. RNA viruses are characterized by their high genetic diversity, which provides fast adaptation to environmental changes and helps them evade most antiviral treatments. Therefore, the study of the adaptive possibilities of RNA viruses is highly relevant for both basic and applied research. In this study we have evolved an RNA virus, the bacteriophage Qβ, under three different temperatures that either were kept constant or alternated periodically. The populations obtained were analyzed at the phenotypic and the genotypic level to characterize the evolutionary process followed by the virus in each case and the amount of convergent genetic changes attained. Finally, we also investigated the influence of the pre-existent genetic diversity on adaptation to high temperature. The main conclusions that arise from our results are: i under periodically changing temperature conditions, evolution of bacteriophage Qβ is driven by the most stringent selective pressure, ii there is a high degree of evolutionary convergence between replicated populations and also among populations evolved at different temperatures, iii there are mutations specific of a particular condition, and iv adaptation to high temperatures in populations differing in their pre-existent genetic diversity takes place through the selection of a common set of mutations.

  17. The rapidly evolving centromere-specific histone has stringent functional requirements in Arabidopsis thaliana.

    Science.gov (United States)

    Ravi, Maruthachalam; Kwong, Pak N; Menorca, Ron M G; Valencia, Joel T; Ramahi, Joseph S; Stewart, Jodi L; Tran, Robert K; Sundaresan, Venkatesan; Comai, Luca; Chan, Simon W-L

    2010-10-01

    Centromeres control chromosome inheritance in eukaryotes, yet their DNA structure and primary sequence are hypervariable. Most animals and plants have megabases of tandem repeats at their centromeres, unlike yeast with unique centromere sequences. Centromere function requires the centromere-specific histone CENH3 (CENP-A in human), which replaces histone H3 in centromeric nucleosomes. CENH3 evolves rapidly, particularly in its N-terminal tail domain. A portion of the CENH3 histone-fold domain, the CENP-A targeting domain (CATD), has been previously shown to confer kinetochore localization and centromere function when swapped into human H3. Furthermore, CENP-A in human cells can be functionally replaced by CENH3 from distantly related organisms including Saccharomyces cerevisiae. We have used cenh3-1 (a null mutant in Arabidopsis thaliana) to replace endogenous CENH3 with GFP-tagged variants. A H3.3 tail domain-CENH3 histone-fold domain chimera rescued viability of cenh3-1, but CENH3's lacking a tail domain were nonfunctional. In contrast to human results, H3 containing the A. thaliana CATD cannot complement cenh3-1. GFP-CENH3 from the sister species A. arenosa functionally replaces A. thaliana CENH3. GFP-CENH3 from the close relative Brassica rapa was targeted to centromeres, but did not complement cenh3-1, indicating that kinetochore localization and centromere function can be uncoupled. We conclude that CENH3 function in A. thaliana, an organism with large tandem repeat centromeres, has stringent requirements for functional complementation in mitosis.

  18. Novel operational approaches to support medical countmeasure response to radiological or nerve agent events

    International Nuclear Information System (INIS)

    Withcomb, R.; Adams, S.

    2009-01-01

    Presentation will highlight two unique operational approaches developed by CDC to support the US Governments rapid medical countermeasure response to radiological and nerve agent exposures. Specifically new CDC's DTPA Forward Placement Project and CHEMPACK program will be discussed and contrasted as will the planning efforts necessary to develop an optimized operational approach and integrate each of these countermeasures into a rapid medical response program whose success is dependent on collaboration of both National and local authorities.(author)

  19. NASA Headquarters Space Operations Center: Providing Situational Awareness for Spaceflight Contingency Response

    Science.gov (United States)

    Maxwell, Theresa G.; Bihner, William J.

    2010-01-01

    This paper discusses the NASA Headquarters mishap response process for the Space Shuttle and International Space Station programs, and how the process has evolved based on lessons learned from the Space Shuttle Challenger and Columbia accidents. It also describes the NASA Headquarters Space Operations Center (SOC) and its special role in facilitating senior management's overall situational awareness of critical spaceflight operations, before, during, and after a mishap, to ensure a timely and effective contingency response.

  20. Realistic operator response measurements: Inputs to the LaSalle PRA

    International Nuclear Information System (INIS)

    Crane, G.R.; Hannaman, G.W.

    1986-01-01

    The LaSalle comprehensive probabilistic risk assessment (PRA) includes external events and internal events with explicit treatment of human actions during operations, maintenance, and surveillance. It includes common-cause considerations and dependencies covering all support functions. These human sections are included in the same fault trees applicable to both external and internal events. Realism is incorporated into the PRA via measurable values of plant parameters in contrast to license-base values, via real-time behavior of primary containment which provides more realistic operator response intervals, and via actual measurements of operator responses during engineering simulator exercise of plant-specific transient and accident events. Preliminary correlations of operator responses via the HCR measurements method indicate that measured operator unreliabilities are consistently ten to one hundred times lower than best-estimate values used in earlier PRA's. Some operator responses may indicate an unreliability measure of one thousand less than reported estimates of non-performance (omission failures). Measurements of operator response during plant recovery scenarios are currently being correlated for subsequent inclusion via SHARP methods into the LaSalle PRA. These degraded core event scenarios were defined from the PRA dominant transient and accident cut-sets leading to degraded cores with potential fission product release

  1. Real Options as a Strategic Management Framework: A Case Study of the Operationally Responsive Space Initiative

    Science.gov (United States)

    2007-03-01

    REAL OPTIONS AS A STRATEGIC MANAGEMENT FRAMEWORK: A...AFIT/GRD/ENV/07-M2 REAL OPTIONS AS A STRATEGIC MANAGEMENT FRAMEWORK: A CASE STUDY OF THE OPERATIONALLY RESPONSIVE SPACE INITIATIVE THESIS...DISTRIBUTION UNLIMITED. AFIT/GRD/ENV/07-M2 REAL OPTIONS AS A STRATEGIC MANAGEMENT FRAMEWORK: A CASE STUDY OF THE OPERATIONALLY

  2. 41 CFR 109-38.301-1.53 - Responsibilities of motor vehicle operators.

    Science.gov (United States)

    2010-07-01

    ... motor vehicle operators. 109-38.301-1.53 Section 109-38.301-1.53 Public Contracts and Property... MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 38-MOTOR EQUIPMENT MANAGEMENT 38.3-Official Use of Government Motor Vehicles § 109-38.301-1.53 Responsibilities of motor vehicle operators...

  3. Preliminary evaluation of the Accident Response Mobile Manipulation System for accident site salvage operations

    International Nuclear Information System (INIS)

    Trujillo, J.M.; Morse, W.D.; Jones, D.P.

    1994-01-01

    This paper describes and evaluates operational experiences with the Accident Response Mobile Manipulation System (ARMMS) during simulated accident site salvage operations which might involve nuclear weapons. The ARMMS is based upon a teleoperated mobility platform with two Schilling Titan 7F Manipulators

  4. Columbia River System Operation Review final environmental impact statement. Appendix T: Comments and responses

    International Nuclear Information System (INIS)

    1995-11-01

    The System Operation Review (SOR) is a study and environmental compliance process being used by the three Federal agencies to analyze future operations of the system and river use issues. The goal of the SOR is to achieve a coordinated system operation strategy for the river that better meets the needs of all river users. This technical appendix addresses only the effects of alternative system operating strategies for managing the Columbia River system. This appendix documents the public and agency review of the SOR Draft EIS and how the SOR agencies used the review to formulate the FINAL EIS. The appendix includes a summary of the review process, a discussion of the nature of the comments, a list of all commentors, reproductions of comment letters, and responses to all comments. Changes in the EIS text in response to comments are noted in the responses

  5. Direct-to-physician and direct-to-consumer advertising: Time to have stringent regulations.

    Science.gov (United States)

    Kannan, S; Gowri, S; Tyagi, V; Kohli, S; Jain, R; Kapil, P; Bhardwaj, A

    2015-01-01

    the opinion regarding DTCA, 69.9% physicians had a patient discussing DTCA that was clinically inappropriate. One hundred (64.5%) out of 155 physicians opined that DTCA encourage patients to attend physicians regarding preventive healthcare. On the contrary, 82/155 (52.9%) physicians felt that DTCA would damage the same. Similarly, 69 out of the total 100 patients felt that drug advertisements aid them to have better discussions with their treating physicians. Surprisingly, a large majority (91/100) were of the opinion that only safe drugs are allowed to be advertised. To conclude, from the findings of this study both the physicians and patients should be cautious and not overzealous while dealing with drug advertisements or promotional literature. More stringent scrutiny and issue of WLs or blacklisting of indulging pharmaceutical companies are mandatory by the regulatory agency to contain the same.

  6. The peri-operative cytokine response in infants and young children following major surgery

    DEFF Research Database (Denmark)

    Hansen, Tom Giedsing; Tønnesen, Else Kirstine; Andersen, J B

    1998-01-01

    The peri-operative cytokine response was studied in 13 infants and young children undergoing major surgery. All children were anaesthetized with a combined general and epidural anaesthetic technique, followed by post-operative epidural analgesia with bupivacaine and fentanyl. Blood samples were...... taken before and after surgery, 24 h post-operatively, and finally, when the children were mobilized and had regained gastrointestinal function. Plasma samples were analysed for tumour necrosis factor-alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interferon-gamma, interleukin-10...... and the interleukin-1 receptor antagonist. The cytokine responses were highly variable. Overall, no significant changes between pre- and post-operative plasma concentrations were found. Tumour necrosis factor-alpha and the interleukin-1 receptor antagonist were detectable in all children, and a trend towards an early...

  7. Secure, Autonomous, Intelligent Controller for Integrating Distributed Emergency Response Satellite Operations

    Science.gov (United States)

    Ivancic, William D.; Paulsen, Phillip E.; Miller, Eric M.; Sage, Steen P.

    2013-01-01

    This report describes a Secure, Autonomous, and Intelligent Controller for Integrating Distributed Emergency Response Satellite Operations. It includes a description of current improvements to existing Virtual Mission Operations Center technology being used by US Department of Defense and originally developed under NASA funding. The report also highlights a technology demonstration performed in partnership with the United States Geological Service for Earth Resources Observation and Science using DigitalGlobe(Registered TradeMark) satellites to obtain space-based sensor data.

  8. Clinical Experience of Auditory Brainstem Response Testing on Pediatric Patients in the Operating Room

    Directory of Open Access Journals (Sweden)

    Guangwei Zhou

    2012-01-01

    Full Text Available Objectives. To review our experience of conducting auditory brainstem response (ABR test on children in the operating room and discuss the benefits versus limitations of this practice. Methods. Retrospective review study conducted in a pediatric tertiary care facility. A total of 267 patients identified with usable data, including ABR results, medical and surgical notes, and follow-up evaluation. Results. Hearing status successfully determined in all patients based on the ABR results form the operating room. The degrees and the types of hearing loss also documented in most of the cases. In addition, multiple factors that may affect the outcomes of ABR in the operating room identified. Conclusions. Hearing loss in children with complicated medical issues can be accurately evaluated via ABR testing in the operating room. Efforts should be made to eliminate adverse factors to ABR recording, and caution should be taken when interpreting ABR results from the operating room.

  9. 20 CFR 670.510 - Are Job Corps center operators responsible for providing all vocational training?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Are Job Corps center operators responsible for providing all vocational training? 670.510 Section 670.510 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR THE JOB CORPS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT...

  10. State Regulatory responses to acid rain: Implications for electric utility operations

    International Nuclear Information System (INIS)

    Nagelhout, M.

    1990-01-01

    This article discusses the state regulatory responses to acid rain legislation and how this will affect electric utility operations. Topics discusses include planning and fuel procurement practices, least-cost planning, long-term supply contracts, fuel mix, cogeneration and small power production, qualifying facility contracts, avoided costs, environmental impact, lobbying expense, bill inserts, and forecasting models

  11. Operational Research: Flexible Response to the Needs of Canadian Defence through the Postwar Years.

    Science.gov (United States)

    1980-11-01

    D- 4 OPERAT IONAL RESEARCH :FLE XIBLE RESPONSE TO THE NEEDS OF CANADIA-ETCIU) No V 80 G R LINDSEY UNCLASSIFIED ORAE-MI3OT 7 AAA981OERAIOA...RESPONSE TO THE NEEDS 00 OF CANADIAN DEFENCE THROUGH THE POSTWAR YEARS o BY G.R. LINDSEY DTIC -vaELECTEV APR 2 4 i98i A ORAE MEMORANDUM NO. M103 __ORAE_...OPERATIONAL RESEARCH: FLEXIBLE RESPONSE TO THE NEEDS OF CANADIAN DEFENCE THROUGH THE POSTWAR YEARS Contents Page Abstract/Sommaire

  12. Varying Levels of Automation on UAS Operator Responses to Traffic Resolution Advisories in Civil Airspace

    Science.gov (United States)

    Kenny, Caitlin; Fern, Lisa

    2012-01-01

    Continuing demand for the use of Unmanned Aircraft Systems (UAS) has put increasing pressure on operations in civil airspace. The need to fly UAS in the National Airspace System (NAS) in order to perform missions vital to national security and defense, emergency management, and science is increasing at a rapid pace. In order to ensure safe operations in the NAS, operators of unmanned aircraft, like those of manned aircraft, may be required to maintain separation assurance and avoid loss of separation with other aircraft while performing their mission tasks. This experiment investigated the effects of varying levels of automation on UAS operator performance and workload while responding to conflict resolution instructions provided by the Tactical Collision Avoidance System II (TCAS II) during a UAS mission in high-density airspace. The purpose of this study was not to investigate the safety of using TCAS II on UAS, but rather to examine the effect of automation on the ability of operators to respond to traffic collision alerts. Six licensed pilots were recruited to act as UAS operators for this study. Operators were instructed to follow a specified mission flight path, while maintaining radio contact with Air Traffic Control and responding to TCAS II resolution advisories. Operators flew four, 45 minute, experimental missions with four different levels of automation: Manual, Knobs, Management by Exception, and Fully Automated. All missions included TCAS II Resolution Advisories (RAs) that required operator attention and rerouting. Operator compliance and reaction time to RAs was measured, and post-run NASA-TLX ratings were collected to measure workload. Results showed significantly higher compliance rates, faster responses to TCAS II alerts, as well as less preemptive operator actions when higher levels of automation are implemented. Physical and Temporal ratings of workload were significantly higher in the Manual condition than in the Management by Exception and

  13. Stringent factor and proteolysis control of sigma factor RpoS expression in Vibrio cholerae.

    Science.gov (United States)

    Wurm, Philipp; Tutz, Sarah; Mutsam, Beatrice; Vorkapic, Dina; Heyne, Barbara; Grabner, Claudia; Kleewein, Katharina; Halscheidt, Anja; Schild, Stefan; Reidl, Joachim

    2017-04-01

    Vibrio cholerae can colonize the gastrointestinal track of humans and cause the disease cholera. During colonization, the alternative sigma factor, RpoS, controls a process known as "mucosal escape response," defining a specific spatial and temporal response and effecting chemotaxis and motility. In this report, the expression and proteolytic control of RpoS in V. cholerae was characterized. To date, aspects of proteolysis control, the involved components, and proteolysis regulation have not been addressed for RpoS in V. cholerae. Similar to Escherichia coli, we find that the RpoS protein is subjected to regulated intracellular proteolysis, which is mediated by homologues of the proteolysis-targeting factor RssB and the protease complex ClpXP. As demonstrated, RpoS expression transiently peaks after cells are shifted from rich to minimal growth medium. This peak level is dependent on (p)ppGpp-activated rpoS transcription and controlled RpoS proteolysis. The RpoS peak level also correlates with induction of a chemotaxis gene, encoding a methyl-accepting chemotaxis protein, earlier identified to belong to the mucosal escape response pathway. These results suggest that the RpoS expression peak is linked to (p)ppGpp alarmone increase, leading to enhanced motility and chemotaxis, and possibly contributing to the mucosal escape response. Copyright © 2017 Elsevier GmbH. All rights reserved.

  14. Approaches for Accommodating Demand Response in Operational Problems and Assessing its Value

    DEFF Research Database (Denmark)

    O'Connell, Niamh

    . However, before the necessary investments can be made to establish and operate this novel resource, its value must be determined. As with all current power system resources, if distributed demand response is deployed on a large scale it will be required to interface with the power system and market...... investments will be made to establish and operate the resource. A positive commercial assessment will signal to investors that the resource can offer a return on their investment, and that it can thrive in a competitive environment. We consider both the social welfare and commercial value of demand response...... or revenue through energy arbitrage or load curtailment. This does not rule out that there maybe certain power systems, or sections thereof, that are currently experiencing sufficient resource scarcity to result in a favourable environment for the successful implementation of demand response. At the current...

  15. Orphan Toxin OrtT (YdcX) of Escherichia coli Reduces Growth during the Stringent Response

    Science.gov (United States)

    2015-01-29

    consists of two-components with the exception of the three-component system ω-ε-ζ of Streptococcus pyogenes [37]. Here, we demonstrate the importance of a...often found in cryptic prophage remnants such as PhyL in Bacillus anthracis [35] and LysA in Streptococcus gordonii [36] without the antitoxin genes...36. Ploeg, J.R.v.d. Characterization of Streptococcus gordonii prophage PH15: Complete genome sequence and functional analysis of phage-encoded

  16. Yeast 18 S rRNA Is Directly Involved in the Ribosomal Response to Stringent AUG Selection during Translation Initiation

    Czech Academy of Sciences Publication Activity Database

    Nemoto, N.; Singh, Ch. R.; Udagawa, T.; Wang, S.; Thorson, E.; Winter, Z.; Ohira, T.; Li, M.; Valášek, Leoš; Brown, S. J.; Asano, K.

    2010-01-01

    Roč. 285, č. 42 (2010), s. 32200-32212 ISSN 0021-9258 Institutional research plan: CEZ:AV0Z50200510 Keywords : START CODON SELECTION * SACCHAROMYCES-CEREVISIAE * IN-VIVO Subject RIV: EE - Microbiology, Virology Impact factor: 5.328, year: 2010

  17. Choice of external criteria in back pain research: Does it matter? Recommendations based on analysis of responsiveness

    DEFF Research Database (Denmark)

    Lauridsen, Henrik H; Hartvigsen, Jan; Korsholm, Lars

    2007-01-01

    standardised response mean (SRM). Results demonstrated small variations in ROC(auc) across the external criteria for all outcome measures. 7% more patients were classified as improved in the group receiving the 15-point TQ compared to the 7-point TQ (stringent standard). SRMs were higher for the retrospective......Understanding a change score is indispensable for interpretation of results from clinical studies. One way of determining the relevance of change scores is through the use of transition questions that assesses patients' retrospective perception of treatment effect. Unfortunately, results from...... scale evaluating the importance of the perceived change. Four external criteria were generated using both stringent and less stringent standards to dichotomise patients. Discrimination was determined using area under the receiver operating characteristic curve (ROC(auc)) and responsiveness using...

  18. Puerto Rico Seismic Network Operations During and After the Hurricane Maria: Response, Continuity of Operations, and Experiences

    Science.gov (United States)

    Vanacore, E. A.; Baez-Sanchez, G.; Huerfano, V.; Lopez, A. M.; Lugo, J.

    2017-12-01

    The Puerto Rico Seismic Network (PRSN) is an integral part of earthquake and tsunami monitoring in Puerto Rico and the Virgin Islands. The PRSN conducts scientific research as part of the University of Puerto Rico Mayaguez, conducts the earthquake monitoring for the region, runs extensive earthquake and tsunami education and outreach programs, and acts as a Tsunami Warning Focal Point Alternate for Puerto Rico. During and in the immediate aftermath of Hurricane Maria, the PRSN duties and responsibilities evolved from a seismic network to a major information and communications center for the western side of Puerto Rico. Hurricane Maria effectively destroyed most communications on island, critically between the eastern side of the island where Puerto Rico's Emergency Management's (PREMA) main office and the National Weather Service (NWS) is based and the western side of the island. Additionally, many local emergency management agencies on the western side of the island lost a satellite based emergency management information system called EMWIN which provides critical tsunami and weather information. PRSN's EMWIN system remained functional and consequently via this system and radio communications PRSN became the only information source for NWS warnings and bulletins, tsunami alerts, and earthquake information for western Puerto Rico. Additionally, given the functional radio and geographic location of the PRSN, the network became a critical communications relay for local emergency management. Here we will present the PRSN response in relation to Hurricane Maria including the activation of the PRSN devolution plan, adoption of duties, experiences and lessons learned for continuity of operations and adoption of responsibilities during future catastrophic events.

  19. Hybrid Decision-making Method for Emergency Response System of Unattended Train Operation Metro

    Directory of Open Access Journals (Sweden)

    Bobo Zhao

    2016-04-01

    Full Text Available Suitable selection of the emergency alternatives is a critical issue in emergency response system of Unattended Train Operation (UTO metro system of China. However, there is no available method for dispatcher group in Operating Control Center (OCC to evaluate the decision under emergency situation. It was found that the emergency decision making in UTO metro system is relative with the preferences and the importance of multi-dispatcher in emergency. Regarding these factors, this paper presents a hybrid method to determinate the priority weights of emergency alternatives, which aggregates the preference matrix by constructing the emergency response task model based on the Weighted Ordered Weighted Averaging (WOWA operator. This calculation approach derives the importance weights depending on the dispatcher emergency tasks and integrates it into the Ordered Weighted Averaging (OWA operator weights based on a fuzzy membership relation. A case from train fire is given to demonstrate the feasibility and practicability of the proposed methods for Group Multi-Criteria Decision Making (GMCDM in emergency management of UTO metro system. The innovation of this research is paving the way for a systematic emergency decision-making solution which connects the automatic metro emergency response system with the GMCDM theory.

  20. Ubiquitous robust communications for emergency response using multi-operator heterogeneous networks

    Directory of Open Access Journals (Sweden)

    Verikoukis Christos

    2011-01-01

    Full Text Available Abstract A number of disasters in various places of the planet have caused an extensive loss of lives, severe damages to properties and the environment, as well as a tremendous shock to the survivors. For relief and mitigation operations, emergency responders are immediately dispatched to the disaster areas. Ubiquitous and robust communications during the emergency response operations are of paramount importance. Nevertheless, various reports have highlighted that after many devastating events, the current technologies used, failed to support the mission critical communications, resulting in further loss of lives. Inefficiencies of the current communications used for emergency response include lack of technology inter-operability between different jurisdictions, and high vulnerability due to their centralized infrastructure. In this article, we propose a flexible network architecture that provides a common networking platform for heterogeneous multi-operator networks, for interoperation in case of emergencies. A wireless mesh network is the main part of the proposed architecture and this provides a back-up network in case of emergencies. We first describe the shortcomings and limitations of the current technologies, and then we address issues related to the applications and functionalities a future emergency response network should support. Furthermore, we describe the necessary requirements for a flexible, secure, robust, and QoS-aware emergency response multi-operator architecture, and then we suggest several schemes that can be adopted by our proposed architecture to meet those requirements. In addition, we suggest several methods for the re-tasking of communication means owned by independent individuals to provide support during emergencies. In order to investigate the feasibility of multimedia transmission over a wireless mesh network, we measured the performance of a video streaming application in a real wireless metropolitan multi

  1. Investigation of Response Amplitude Operators for Floating Offshore Wind Turbines: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Ramachandran, G. K. V.; Robertson, A.; Jonkman, J. M.; Masciola, M. D.

    2013-07-01

    This paper examines the consistency between response amplitude operators (RAOs) computed from WAMIT, a linear frequency-domain tool, to RAOs derived from time-domain computations based on white-noise wave excitation using FAST, a nonlinear aero-hydro-servo-elastic tool. The RAO comparison is first made for a rigid floating wind turbine without wind excitation. The investigation is further extended to examine how these RAOs change for a flexible and operational wind turbine. The RAOs are computed for below-rated, rated, and above-rated wind conditions. The method is applied to a floating wind system composed of the OC3-Hywind spar buoy and NREL 5-MW wind turbine. The responses are compared between FAST and WAMIT to verify the FAST model and to understand the influence of structural flexibility, aerodynamic damping, control actions, and waves on the system responses. The results show that based on the RAO computation procedure implemented, the WAMIT- and FAST-computed RAOs are similar (as expected) for a rigid turbine subjected to waves only. However, WAMIT is unable to model the excitation from a flexible turbine. Further, the presence of aerodynamic damping decreased the platform surge and pitch responses, as computed by both WAMIT and FAST when wind was included. Additionally, the influence of gyroscopic excitation increased the yaw response, which was captured by both WAMIT and FAST.

  2. Software Architecture Coupling Metric for Assessing Operational Responsiveness of Trading Systems

    Directory of Open Access Journals (Sweden)

    Claudiu VINTE

    2012-01-01

    Full Text Available The empirical observation that motivates our research relies on the difficulty to assess the performance of a trading architecture beyond a few synthetic indicators like response time, system latency, availability or volume capacity. Trading systems involve complex software architectures of distributed resources. However, in the context of a large brokerage firm, which offers a global coverage from both, market and client perspectives, the term distributed gains a critical significance indeed. Offering a low latency ordering system by nowadays standards is relatively easily achievable, but integrating it in a flexible manner within the broader information system architecture of a broker/dealer requires operational aspects to be factored in. We propose a metric for measuring the coupling level within software architecture, and employ it to identify architectural designs that can offer a higher level of operational responsiveness, which ultimately would raise the overall real-world performance of a trading system.

  3. A stringently controlled expression system for analysing lateral gene transfer between bacteria.

    Science.gov (United States)

    Jaenecke, S; de Lorenzo, V; Timmis, K N; Díaz, E

    1996-07-01

    The lateral transfer of genetic information among microorganisms is a major force driving the outstanding adaptability of microbial communities to environmental changes. Until now little information has been obtained on gene transfer in natural ecosystems. We present here a genetic circuit for detecting and quantifying horizontal gene transfer from a defined donor microorganism to recipient organisms in the absence of selection for a recipient-specific phenotype. The system consists of an engineered lacZ (encoding beta-galactosidase) reporter gene whose expression is controlled by a synthetic regulatory element based on a fusion between the Pr promoter-operator from lambda bacteriophage and the 5' non-coding leader region of the inp gene encoding the IS 10 transposase function. Expression of this reporter cassette in the recombinant microorganism is completely shut down by two chromosomally encoded trans-acting repressors working at the level of transcription (the Cl-EK117 protein from the lambda phage), and at the level of translation (the antisense RNA-OUT of the IS 10 element). When the reporter element is transferred to a different host by any mechanism, it escapes repression and becomes expressed. The system was validated with Pseudo-monas putida, and conjugational transfer frequencies of the reporter element as low as 10(-6) were detected. The modular design and broad host range of the genetic circuit, in combination with biomarkers which permit real-time in situ detection, will facilitate the monitor-ing of gene flow in a non-disruptive manner within the environment.

  4. A study on operators' cognitive response characteristics to the computerized working environment

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Hee; Lee, Jang Soo; Suh, Sang Moon; Lee, Hyun Cheol; Jung, Kwang Tae; Lee, Dhong Ha

    1998-12-01

    Although the introduction of computerized working environment to the nuclear facilities, the study on the human factors impacts of computers and automation has not been enough like the other industries. It is necessary to prepare the way to cope with the negative aspects in spite of many positive aspects of computerization in nuclear. This study is an empirical study including the survey of the human factor concerning, especially to the cognitive response of operators' and the experiments on the error proneness. At first, we survey the design and its changes of operator interface and interaction in nuclear power plants, and conclude five human factor issues. We discuss situation awareness issues as one of the major human factor concerning, and the assessment method. Secondly, a questionnaire and interviews survey to the operator's response characteristics are performed for possible criterion measures to the in-depth study on the cognitive characteristics. Finally, several experiments are conducted to test the error proneness. The issues and findings of this study could be utilized to any further study on the cognitive characteristic of operators to the computerized work environment.

  5. A study on operators' cognitive response characteristics to the computerized working environment

    International Nuclear Information System (INIS)

    Lee, Yong Hee; Lee, Jang Soo; Suh, Sang Moon; Lee, Hyun Cheol; Jung, Kwang Tae; Lee, Dhong Ha

    1998-12-01

    Although the introduction of computerized working environment to the nuclear facilities, the study on the human factors impacts of computers and automation has not been enough like the other industries. It is necessary to prepare the way to cope with the negative aspects in spite of many positive aspects of computerization in nuclear. This study is an empirical study including the survey of the human factor concerning, especially to the cognitive response of operators' and the experiments on the error proneness. At first, we survey the design and its changes of operator interface and interaction in nuclear power plants, and conclude five human factor issues. We discuss situation awareness issues as one of the major human factor concerning, and the assessment method. Secondly, a questionnaire and interviews survey to the operator's response characteristics are performed for possible criterion measures tot he in-depth study on the cognitive characteristics. Finally, several experiments are conducted to test the error proneness. The issues and findings of this study could be utilized to any further study on the cognitive characteristic of operators to the computerized work environment

  6. How operator admittance affects the response of a teleoperation system to assistive forces – A model analytic study and simulation

    NARCIS (Netherlands)

    Wildenbeest, J. G. W.; Abbink, D. A.; Boessenkool, H.; Heemskerk, C. J. M.; Koning, J. F.

    2013-01-01

    Haptic shared control is a promising approach to increase the effectiveness of remote handling operations. While in haptic shared control the operator is continuously guided with assistive forces, the operator's response to forces is not fully understood. This study describes the development of

  7. Medical Operations Console Procedure Evaluation: BME Response to Crew Call Down for an Emergency

    Science.gov (United States)

    Johnson-Troop; Pettys, Marianne; Hurst, Victor, IV; Smaka, Todd; Paul, Bonnie; Rosenquist, Kevin; Gast, Karin; Gillis, David; McCulley, Phyllis

    2006-01-01

    International Space Station (ISS) Mission Operations are managed by multiple flight control disciplines located at the lead Mission Control Center (MCC) at NASA-Johnson Space Center (JSC). ISS Medical Operations are supported by the complementary roles of Flight Surgeons (Surgeon) and Biomedical Engineer (BME) flight controllers. The Surgeon, a board certified physician, oversees all medical concerns of the crew and the BME provides operational and engineering support for Medical Operations Crew Health Care System. ISS Medical Operations is currently addressing the coordinated response to a crew call down for an emergent medical event, in particular when the BME is the only Medical Operations representative in MCC. In this case, the console procedure BME Response to Crew Call Down for an Emergency will be used. The procedure instructs the BME to contact a Surgeon as soon as possible, coordinate with other flight disciplines to establish a Private Medical Conference (PMC) for the crew and Surgeon, gather information from the crew if time permits, and provide Surgeon with pertinent console resources. It is paramount that this procedure is clearly written and easily navigated to assist the BME to respond consistently and efficiently. A total of five BME flight controllers participated in the study. Each BME participant sat in a simulated MCC environment at a console configured with resources specific to the BME MCC console and was presented with two scripted emergency call downs from an ISS crew member. Each participant used the procedure while interacting with analog MCC disciplines to respond to the crew call down. Audio and video recordings of the simulations were analyzed and each BME participant's actions were compared to the procedure. Structured debriefs were conducted at the conclusion of both simulations. The procedure was evaluated for its ability to elicit consistent responses from each BME participant. Trials were examined for deviations in procedure task

  8. The implementation of modern digital technology in x-ray medical diagnosis in Republic of Moldova - a stringent necessity

    International Nuclear Information System (INIS)

    Rosca, Andrei

    2011-01-01

    The study includes analyses of current technical state of radiodiagnostic equipment from the Public Medico-Sanitary Institution of Ministry of Health of Republic of Moldova (IMSP MS RM). The traditional radiodiagnostic apparatuses were morally and physically outrun at 96,6% (in regional MSPI - 93,5%), inclusive the dental one - 92,0% (in raional MSPI - 97,2%), X-Ray exam -100%, mobile - 84,1% etc. The exploitation of the traditional radiodiagnostic apparatuses with high degree of physical and moral wear essentially diminished the quality of profile investigation, creates premises for diagnostic error perpetrating, increase the collective ionizing irradiation of population etc. In recent years the subvention of MSPI HM RM with digital radiodiagnostic equipment was started. This process is very hard unfold because of grave socio-economic crises in Republic of Moldova. Despite these obstacles the subvention of MSPI HM RM with digital equipment represents a stringent necessity and a time request.

  9. Earthquake Response Modeling for a Parked and Operating Megawatt-Scale Wind Turbine

    Energy Technology Data Exchange (ETDEWEB)

    Prowell, I.; Elgamal, A.; Romanowitz, H.; Duggan, J. E.; Jonkman, J.

    2010-10-01

    Demand parameters for turbines, such as tower moment demand, are primarily driven by wind excitation and dynamics associated with operation. For that purpose, computational simulation platforms have been developed, such as FAST, maintained by the National Renewable Energy Laboratory (NREL). For seismically active regions, building codes also require the consideration of earthquake loading. Historically, it has been common to use simple building code approaches to estimate the structural demand from earthquake shaking, as an independent loading scenario. Currently, International Electrotechnical Commission (IEC) design requirements include the consideration of earthquake shaking while the turbine is operating. Numerical and analytical tools used to consider earthquake loads for buildings and other static civil structures are not well suited for modeling simultaneous wind and earthquake excitation in conjunction with operational dynamics. Through the addition of seismic loading capabilities to FAST, it is possible to simulate earthquake shaking in the time domain, which allows consideration of non-linear effects such as structural nonlinearities, aerodynamic hysteresis, control system influence, and transients. This paper presents a FAST model of a modern 900-kW wind turbine, which is calibrated based on field vibration measurements. With this calibrated model, both coupled and uncoupled simulations are conducted looking at the structural demand for the turbine tower. Response is compared under the conditions of normal operation and potential emergency shutdown due the earthquake induced vibrations. The results highlight the availability of a numerical tool for conducting such studies, and provide insights into the combined wind-earthquake loading mechanism.

  10. Global energy scenarios meeting stringent CO2 constraints - cost-effective fuel choices in the transportation sector

    International Nuclear Information System (INIS)

    Azar, Christian; Lindgren, Kristian; Andersson, B.A.

    2003-01-01

    The purpose of this paper is to assess fuel choices in the transportation sector under stringent global carbon constraints. Three key questions are asked: (i) when is it cost-effective to carry out the transition away from gasoline/diesel; (ii) to which fuel is it cost-effective to shift; and (iii) in which sector is biomass most cost-effectively used? These questions are analyzed using a global energy systems model (GET 1.0), with a transportation module, where vehicle costs (fuel cell, reformer and storage tank), infrastructure and primary energy availability are treated explicitly. The model is run under the assumption that atmospheric concentrations of CO 2 should be stabilized at 400 ppm. Three main results emerge: (i) despite the stringent CO 2 constraints, oil-based fuels remain dominant in the transportation sector over the next 50 years; and (ii) once a transition towards alternative fuels takes place, the preferred choice of fuel is hydrogen, even if we assume that hydrogen fuel cell vehicles are substantially more costly than methanol fuel cell vehicles. There may, under some circumstances, be a transient period of several decades with a significant share of methanol in the transportation sector. (iii) Biomass is most cost-effectively used in the heat and process heat sectors. If carbon sequestration from biomass is allowed, biomass is primarily used for hydrogen generation since small-scale heat applications are not suitable for carbon sequestration. Detailed sensitivity analyses show that these results are robust with respect to several parameters. Some policy conclusions are drawn

  11. Hospital response to chemical terrorism: personal protective equipment, training, and operations planning.

    Science.gov (United States)

    Georgopoulos, Panos G; Fedele, Paul; Shade, Pamela; Lioy, Paul J; Hodgson, Michael; Longmire, Atkinson; Sands, Melody; Brown, Mark A

    2004-11-01

    Hospitals distant from the immediate site of an incident involving a hazardous materials (HAZMATs) release which could include chemical warfare agents, must develop emergency response plans (ERPs) to protect healthcare professionals if they receive potentially contaminated victims. The ERP must address OSHA, EPA, and JCAHO requirements. The VHA convened groups to develop a hazard and exposure assessment, identify actions for compliance with existing regulatory standards, and review site and operational planning issues. Exposure modeling results were used to derive relationships between operational parameters (time and distance from sites/sources) and potential exposure for healthcare workers. According to exposure modeling, level C personal protective equipment is adequate to protect hospital staff distant from the chemical release site. Decontamination runoff and contaminated clothing should also be controlled to limit exposure. Development and coordination of ERPs must include the local emergency planning committee, with clear assignment of tasks, locations, and training in order to prevent exposures to healthcare workers. Copyright 2004 Wiley-Liss, Inc.

  12. Use of structured personality survey techniques to indicate operator response to stressful situations

    International Nuclear Information System (INIS)

    Waller, M.A.

    1990-01-01

    Under given circumstances, a person will tend to operate in one of four dominant orientations: (1) to perform tasks; (2) to achieve consensus; (3) to achieve understanding, or (4) to maintain structure. Historically, personality survey techniques, such as the Myers-Briggs type indicator, have been used to determine these tendencies. While these techniques can accurately reflect a person's orientation under normal social situations, under different sets of conditions, the same person may exhibit other tendencies, displaying a similar or entirely different orientation. While most do not exhibit extreme tendencies or changes of orientation, the shift in personality from normal to stressful conditions can be rather dramatic, depending on the individual. Structured personality survey techniques have been used to indicate operator response to stressful situations. These techniques have been extended to indicate the balance between orientations that the control room team has through the various levels of cognizance

  13. Thermal-structural response of EBR-II major components under reactor operational transients

    International Nuclear Information System (INIS)

    Chang, L.K.; Lee, M.J.

    1983-01-01

    Until recently, the LMFBR safety research has been focused primarily on severe but highly unlikely accident, such as hypothetical-core-disruptive accidents (HCDA's), and not enough attention has been given to accident prevention, which is less severe but more likely sequence. The objective of the EBR-II operational reliability testing (ORT) is to demonstrate that the reactor can be designed and operated to prevent accident. A series of mild duty cycles and overpower transients were designed for accident prevention tests. An assessment of the EBR-II major plant components has been performed to assure structural integrity of the reactor plant for the ORT program. In this paper, the thermal-structural response and structural evaluation of the reactor vessel, the reactor-vessel cover, the intermediate heat exchanger (IHX) and the superheater are presented

  14. Preliminary report on operational guidelines developed for use in emergency preparedness and response to a radiological dispersal device incident.

    Energy Technology Data Exchange (ETDEWEB)

    Yu, C.; Cheng, J.-J.; Kamboj, S.; Domotor, S.; Wallo, A.; Environmental Science Division; DOE

    2006-12-15

    This report presents preliminary operational guidelines and supporting work products developed through the interagency Operational Guidelines Task Group (OGT). The report consolidates preliminary operational guidelines, all ancillary work products, and a companion software tool that facilitates their implementation into one reference source document. The report is intended for interim use and comment and provides the foundation for fostering future reviews of the operational guidelines and their implementation within emergency preparedness and response initiatives in the event of a radiological dispersal device (RDD) incident. The report principally focuses on the technical derivation and presentation of the operational guidelines. End-user guidance providing more details on how to apply these operational guidelines within planning and response settings is being considered and developed elsewhere. The preliminary operational guidelines are categorized into seven groups on the basis of their intended application within early, intermediate, and long-term recovery phases of emergency response. We anticipate that these operational guidelines will be updated and refined by interested government agencies in response to comments and lessons learned from their review, consideration, and trial application. This review, comment, and trial application process will facilitate the selection of a final set of operational guidelines that may be more or less inclusive of the preliminary operational guidelines presented in this report. These and updated versions of the operational guidelines will be made available through the OGT public Web site (http://ogcms.energy.gov) as they become finalized for public distribution and comment.

  15. Nuclear controls are stringent

    International Nuclear Information System (INIS)

    Sonnekus, D.

    1983-01-01

    The peace-time application of nuclear power in South Africa, the organisations concerned and certain provisions laid down by the Act on Nuclear Energy, aimed at safeguarding the general public, are discussed

  16. A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve

    OpenAIRE

    Yi, Ying; Zaher, Amir; Yassine, Omar; Kosel, Jurgen; Foulds, Ian G.

    2015-01-01

    Implantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treat...

  17. PREDICTION OF SURFACE ROUGHNESS IN END MILLING OPERATION OF DUPLEX STAINLESS STEEL USING RESPONSE SURFACE METHODOLOGY

    Directory of Open Access Journals (Sweden)

    S. D. PHILIP

    2015-03-01

    Full Text Available Response surface methodology has been used to study the effects of the machining parameters such as spindle speed, feed rate and axial depth of cut on surface roughness of duplex stainless steel in end milling operation. Dry milling experiments were conducted with three levels of spindle speed, feed rate and axial depth of cut. A mathematical model has been developed to predict the surface roughness in terms of the machining parameters using Box-Behnken design response surface methodology. The adequacy of the model was verified using analysis of variance. The prediction equation shows that the feed rate is the most important factor that influences the surface roughness followed by axial depth of cut and spindle speed. The validity of the model was verified by conducting the confirmation experiment.

  18. Building political will for HIV response: an operational model and strategy options.

    Science.gov (United States)

    Brinkerhoff, Derick W

    2016-10-01

    As global programs for HIV response look to transfer responsibility and financing increasingly to country governments, the political will to take on these responsibilities becomes increasingly prominent. However, defining and assessing political will are problematic; it involves intent and motivation, and thus is inherently difficult to observe. It is intimately connected to capacity and is contextually embedded. This article describes an operational model of political will comprised of seven components that are observable and measurable. Two case studies illustrate the application of the model and shed light on the interconnections among commitment, capacity and context: South Africa and China. Strategy options to build political will for HIV response identify possible actions for both government and civil society. Political will as a concept is most usefully viewed as integrated within larger political and bureaucratic processes, as a product of the complex array of incentives and disincentives that those processes create. However, this conclusion is not a recipe for discouragement or inaction. Agent-based conceptualizations of policy change offer a solid grounding for building political will that supports HIV policy and programs. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  19. Time and the Paradigm of Operational Art - Authority and Responsibility of the Operational Artist in the Political Military Discourse

    Science.gov (United States)

    2017-02-15

    spheres–the US-led free world and the bloc of communism –the seed of the Cold War .57 The Korean War from 1950 to 1953 with its final stalemate illustrated...Relationship of Political Aim and War -Narrative ............... 45 Section IV: Conclusion–The Expansion of the Paradigm of Operational Art...art of operations as a philosophy at every level of war seems to be appropriate. The evaluation of time, its integration, and therefore expansion of

  20. OPTIMIZATION OF SESAME SEEDS OIL EXTRACTION OPERATING CONDITIONS USING THE RESPONSE SURFACE DESIGN METHODOLOGY

    Directory of Open Access Journals (Sweden)

    HAITHAM OSMAN

    2016-12-01

    Full Text Available This paper applies Response Surface Design (RSD to model the experimental data obtained from the extraction of sesame seeds oil using n-hexane, chloroform and acetone as solvents under different operating conditions. The results obtained revealed that n-hexane outperformed the extraction obtained using chloroform and acetone. The developed model predicted that n-hexane with a rotational speed of 547 rpm and a contact time between the solvent and seeds of 19.46 hours with solvent: seeds ratio of 4.93, yields the optimum oil extracted of 37.03 %, outperforming chloroform and acetone models that gave prediction for 4.75 and 4.21 respectively. While the maximum predictions yield for chloroform is 6.73 %, under the operating conditions of 602 rpm, and 24 hours contact time, with a ratio of solvent: seeds of 1.74. On the other hand the acetone maximum prediction is only 4.37 %, with operational conditions of 467 rpm, and 6.00 hours contact time, with a ratio of solvent: seeds of 1. It is has been found that the maximum oil extraction yield obtained from the chloroform (6.73 % and Acetone (4.37 % is much lower than that predicted by n-hexane 37.03 %.

  1. Operant Conditioning in Honey Bees (Apis mellifera L.): The Cap Pushing Response.

    Science.gov (United States)

    Abramson, Charles I; Dinges, Christopher W; Wells, Harrington

    2016-01-01

    The honey bee has been an important model organism for studying learning and memory. More recently, the honey bee has become a valuable model to understand perception and cognition. However, the techniques used to explore psychological phenomena in honey bees have been limited to only a few primary methodologies such as the proboscis extension reflex, sting extension reflex, and free flying target discrimination-tasks. Methods to explore operant conditioning in bees and other invertebrates are not as varied as with vertebrates. This may be due to the availability of a suitable response requirement. In this manuscript we offer a new method to explore operant conditioning in honey bees: the cap pushing response (CPR). We used the CPR to test for difference in learning curves between novel auto-shaping and more traditional explicit-shaping. The CPR protocol requires bees to exhibit a novel behavior by pushing a cap to uncover a food source. Using the CPR protocol we tested the effects of both explicit-shaping and auto-shaping techniques on operant conditioning. The goodness of fit and lack of fit of these data to the Rescorla-Wagner learning-curve model, widely used in classical conditioning studies, was tested. The model fit well to both control and explicit-shaping results, but only for a limited number of trials. Learning ceased rather than continuing to asymptotically approach the physiological most accurate possible. Rate of learning differed between shaped and control bee treatments. Learning rate was about 3 times faster for shaped bees, but for all measures of proficiency control and shaped bees reached the same level. Auto-shaped bees showed one-trial learning rather than the asymptotic approach to a maximal efficiency. However, in terms of return-time, the auto-shaped bees' learning did not carry over to the covered-well test treatments.

  2. How operator admittance affects the response of a teleoperation system to assistive forces – A model analytic study and simulation

    International Nuclear Information System (INIS)

    Wildenbeest, J.G.W.; Abbink, D.A.; Boessenkool, H.; Heemskerk, C.J.M.; Koning, J.F.

    2013-01-01

    Highlights: ► We developed a computational model of a human operator controlling a teleoperation system based on feedforward control, while performing a free-space motion. ► We studied how assistive forces affect the response of the combined system of telemanipulator and operator, when operator admittance changes due to task instruction or arm configuration. ► Inappropriate assistive forces can lead to assistive forces that are either not perceived, or deflect the combined system; assistive forces should be tailored to operator admittance. ► It is required to study, measure and quantitatively model operator behavior for teleoperated tasks in more detail. -- Abstract: Haptic shared control is a promising approach to increase the effectiveness of remote handling operations. While in haptic shared control the operator is continuously guided with assistive forces, the operator's response to forces is not fully understood. This study describes the development of a computational model of a human operator controlling a teleoperation system based on feedforward control. In a simulation, the operator's response to repulsive forces in free-space motions was modeled for two degrees of freedom, for two operator endpoint admittances (estimated by means of closed-loop identification techniques). The simulation results show that similar repulsive forces lead to substantial discrepancies in response when admittance settings mismatch; wrongly estimated operator admittances can lead to assistive forces that are either not perceived, or deflect the combined system of human operator and telemanipulator. It is concluded that assistive forces should be tailored to the arm configuration and the type of task performed. In order to utilize haptic shared control to its full potential, it is required to study, measure and quantitatively model operator behavior for teleoperated tasks in more detail

  3. Operation Optimization in a Smart Micro-Grid in the Presence of Distributed Generation and Demand Response

    Directory of Open Access Journals (Sweden)

    Yongli Wang

    2018-03-01

    Full Text Available With the application of distributed generation and the development of smart grid technology, micro-grid, an economic and stable power grid, tends to play an important role in the demand side management. Because micro-grid technology and demand response have been widely applied, what Demand Response actions can realize the economic operation of micro-grid has become an important issue for utilities. In this proposed work, operation optimization modeling for micro-grid is done considering distributed generation, environmental factors and demand response. The main contribution of this model is to optimize the cost in the context of considering demand response and system operation. The presented optimization model can reduce the operation cost of micro-grid without bringing discomfort to the users, thus increasing the consumption of clean energy effectively. Then, to solve this operational optimization problem, genetic algorithm is used to implement objective function and DR scheduling strategy. In addition, to validate the proposed model, it is employed on a smart micro-grid from Tianjin. The obtained numerical results clearly indicate the impact of demand response on economic operation of micro-grid and development of distributed generation. Besides, a sensitivity analysis on the natural gas price is implemented according to the situation of China, and the result shows that the natural gas price has a great influence on the operation cost of the micro-grid and effect of demand response.

  4. Attenuation of pressor response and dose sparing of opioids and anaesthetics with pre-operative dexmedetomidine

    Directory of Open Access Journals (Sweden)

    Sukhminder Jit Singh Bajwa

    2012-01-01

    Full Text Available Background and Aims: Alpha-2 agonists are being increasingly used as adjuncts in general anaesthesia, and the present study was carried out to investigate the ability of intravenous dexmedetomidine in decreasing the dose of opioids and anaesthetics for attenuation of haemodynamic responses during laryngoscopy and tracheal intubation. Methods: One hundred patients scheduled for elective general surgery were randomized into two groups: D and F (n=50 in each group. Group D were administered 1 μg/kg each of dexmedetomidine and fentanyl while group F received 2 μg/kg of fentanyl pre-operatively. Thiopental was given until eyelash reflex disappeared. Anaesthesia was maintained with 33:66 oxygen: nitrous oxide. Isoflurane concentration was adjusted to maintain systolic blood pressure within 20% of the pre-operative values. Haemodynamic parameters were recorded at regular intervals during induction, intubation, surgery and extubation. Statistical analysis was carried out using analysis of variance, chi-square test, Student′s t test and Mann-Whitney U test. Results: The demographic profile was comparable. The pressor response to laryngoscopy, intubation, surgery and extubation were effectively decreased by dexmedetomidine, and were highly significant on comparison (P50% by the administration of dexmedetomidine. The mean recovery time was also shorter in group D as compared with group F (P=0.014. Conclusions: Dexmedetomidine is an excellent drug as it not only decreased the magnitude of haemodynamic response to intubation, surgery and extubation but also decreased the dose of opioids and isoflurane in achieving adequate analgesia and anaesthesia, respectively.

  5. Are Dutch residents ready for a more stringent policy to enhance the energy performance of their homes?

    International Nuclear Information System (INIS)

    Middelkoop, Manon van; Vringer, Kees; Visser, Hans

    2017-01-01

    Investments in the energy performance of houses offer good prospects for reducing energy consumption and CO 2 emissions. However, people are not easily convinced of the need to take measures to improve the energy performance of their houses, even when financial benefits outweigh the costs. This article analyses the factors that influence the decision for improving the energy performance of existing homes, including policy instruments. Subsequently, the article provides policy suggestions on how to stimulate energy performance improvements. Both owners and tenants (50–70%) support government policy on energy performance improvements to existing homes. Nevertheless, people also have strong feelings of autonomy regarding their homes. Our results underline the importance of well-informed and competent decision-makers. Introducing the use of Energy Performance Certificates (EPCs) into the tax system for energy and residential buildings might therefore be an effective way to increase the interest of owners in the EPC, improve the use and effect of this informative instrument, and make the first step towards bridging the tension between autonomy and more stringent instruments.

  6. 20 CFR 670.515 - What responsibilities do the center operators have in managing work-based learning?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What responsibilities do the center operators have in managing work-based learning? 670.515 Section 670.515 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR THE JOB CORPS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Program Activities and Center Operations §...

  7. Operational design and pressure response of large-scale compressed air energy storage in porous formations

    Science.gov (United States)

    Wang, Bo; Bauer, Sebastian

    2017-04-01

    With the rapid growth of energy production from intermittent renewable sources like wind and solar power plants, large-scale energy storage options are required to compensate for fluctuating power generation on different time scales. Compressed air energy storage (CAES) in porous formations is seen as a promising option for balancing short-term diurnal fluctuations. CAES is a power-to-power energy storage, which converts electricity to mechanical energy, i.e. highly pressurized air, and stores it in the subsurface. This study aims at designing the storage setup and quantifying the pressure response of a large-scale CAES operation in a porous sandstone formation, thus assessing the feasibility of this storage option. For this, numerical modelling of a synthetic site and a synthetic operational cycle is applied. A hypothetic CAES scenario using a typical anticline structure in northern Germany was investigated. The top of the storage formation is at 700 m depth and the thickness is 20 m. The porosity and permeability were assumed to have a homogenous distribution with a value of 0.35 and 500 mD, respectively. According to the specifications of the Huntorf CAES power plant, a gas turbine producing 321 MW power with a minimum inlet pressure of 43 bars at an air mass flowrate of 417 kg/s was assumed. Pressure loss in the gas wells was accounted for using an analytical solution, which defines a minimum bottom hole pressure of 47 bars. Two daily extraction cycles of 6 hours each were set to the early morning and the late afternoon in order to bypass the massive solar energy production around noon. A two-year initial filling of the reservoir with air and ten years of daily cyclic operation were numerically simulated using the Eclipse E300 reservoir simulator. The simulation results show that using 12 wells the storage formation with a permeability of 500 mD can support the required 6-hour continuous power output of 321MW, which corresponds an energy output of 3852 MWh per

  8. Enabling Advanced Automation in Spacecraft Operations with the Spacecraft Emergency Response System

    Science.gov (United States)

    Breed, Julie; Fox, Jeffrey A.; Powers, Edward I. (Technical Monitor)

    2001-01-01

    True autonomy is the Holy Grail of spacecraft mission operations. The goal of launching a satellite and letting it manage itself throughout its useful life is a worthy one. With true autonomy, the cost of mission operations would be reduced to a negligible amount. Under full autonomy, any problems (no matter the severity or type) that may arise with the spacecraft would be handled without any human intervention via some combination of smart sensors, on-board intelligence, and/or smart automated ground system. Until the day that complete autonomy is practical and affordable to deploy, incremental steps of deploying ever-increasing levels of automation (computerization of once manual tasks) on the ground and on the spacecraft are gradually decreasing the cost of mission operations. For example, NASA's Goddard Space Flight Center (NASA-GSFC) has been flying spacecraft with low cost operations for several years. NASA-GSFC's SMEX (Small Explorer) and MIDEX (Middle Explorer) missions have effectively deployed significant amounts of automation to enable the missions to fly predominately in 'light-out' mode. Under light-out operations the ground system is run without human intervention. Various tools perform many of the tasks previously performed by the human operators. One of the major issues in reducing human staff in favor of automation is the perceived increased in risk of losing data, or even losing a spacecraft, because of anomalous conditions that may occur when there is no one in the control center. When things go wrong, missions deploying advanced automation need to be sure that anomalous conditions are detected and that key personal are notified in a timely manner so that on-call team members can react to those conditions. To ensure the health and safety of its lights-out missions, NASA-GSFC's Advanced Automation and Autonomy branch (Code 588) developed the Spacecraft Emergency Response System (SERS). The SERS is a Web-based collaborative environment that enables

  9. Operation Unified Response: A Case Study of the Military’s Role in Foreign Disaster Relief Operations

    Science.gov (United States)

    2011-05-05

    are hesitant to work with the military in any context at all on principle (e.g. OXFAM and Medecins Sans Frontieres).43 The United Nations mission to...of Red Cross and Red Crescent Societies, 55 Medecins Sans Frontieres,56 and others. In an ideal situation, all of these organizations would join to...enhancethe response, but non-governmental actors (such as Medecins Sans Frontieres) can take this as a military takeover, and pushback can ensue.66

  10. Stringent constraints on the dark matter annihilation cross section from subhalo searches with the Fermi Gamma-Ray Space Telescope

    Energy Technology Data Exchange (ETDEWEB)

    Berlin, Asher; Hooper, Dan

    2014-01-01

    The dark matter halo of the Milky Way is predicted to contain a very large number of smaller subhalos. As a result of the dark matter annihilations taking place within such objects, the most nearby and massive subhalos could appear as point-like or spatially extended gamma-ray sources, without observable counterparts at other wavelengths. In this paper, we use the results of the Aquarius simulation to predict the distribution of nearby subhalos, and compare this to the characteristics of the unidentified gamma-ray sources observed by the Fermi Gamma-Ray Space Telescope. Focusing on the brightest high latitude sources, we use this comparison to derive limits on the dark matter annihilation cross section. For dark matter particles lighter than ~200 GeV, the resulting limits are the strongest obtained to date, being modestly more stringent than those derived from observations of dwarf galaxies or the Galactic Center. We also derive independent limits based on the lack of unidentified gamma-ray sources with discernible spatial extension, but these limits are a factor of ~2-10 weaker than those based on point-like subhalos. Lastly, we note that four of the ten brightest high-latitude sources exhibit a similar spectral shape, consistent with 30-60 GeV dark matter particles annihilating to b quarks with an annihilation cross section on the order of sigma v ~ (5-10) x 10^-27 cm^3/s, or 8-10 GeV dark matter particles annihilating to taus with sigma v ~ (2.0-2.5) x 10^-27 cm^3/s.

  11. Effects of response-shock interval and shock intensity on free-operant avoidance responding in the pigeon1

    Science.gov (United States)

    Klein, Marty; Rilling, Mark

    1972-01-01

    Two experiments investigated free-operant avoidance responding with pigeons using a treadle-pressing response. In Experiment I, pigeons were initially trained on a free-operant avoidance schedule with a response-shock interval of 32 sec and a shock-shock interval of 10 sec, and were subsequently exposed to 10 values of the response-shock parameter ranging from 2.5 to 150 sec. The functions relating response rate to response-shock interval were similar to the ones reported by Sidman in his 1953 studies employing rats, and were independent of the order of presentation of the response-shock values. Shock rates decreased as response-shock duration increased. In Experiment II, a free-operant avoidance schedule with a response-shock interval of 20 sec and a shock-shock interval of 5 sec was used, and shock intensities were varied over five values ranging from 2 to 32 mA. Response rates increased markedly as shock intensity increased from 2 to 8 mA, but rates changed little with further increases in shock intensity. Shock rates decreased as intensity increased from 2 to 8 mA, and showed little change as intensity increased from 8 to 32 mA. PMID:4652617

  12. Optimal Technology Investment and Operation in Zero-Net-Energy Buildings with Demand Response

    International Nuclear Information System (INIS)

    Stadler, Michael; Siddiqui, Afzal; Marnay, Chris; Hirohisa, Aki; Lai, Judy

    2009-01-01

    The US Department of Energy has launched the Zero-Net-Energy (ZNE) Commercial Building Initiative (CBI) in order to develop commercial buildings that produce as much energy as they use. Its objective is to make these buildings marketable by 2025 such that they minimize their energy use through cutting-edge energy-efficient technologies and meet their remaining energy needs through on-site renewable energy generation. We examine how such buildings may be implemented within the context of a cost- or carbon-minimizing microgrid that is able to adopt and operate various technologies, such as photovoltaic (PV) on-site generation, heat exchangers, solar thermal collectors, absorption chillers, and passive/demand-response technologies. We use a mixed-integer linear program (MILP) that has a multi-criteria objective function: the minimization of a weighted average of the building's annual energy costs and carbon/CO2 emissions. The MILP's constraints ensure energy balance and capacity limits. In addition, constraining the building's energy consumed to equal its energy exports enables us to explore how energy sales and demand-response measures may enable compliance with the CBI. Using a nursing home in northern California and New York with existing tariff rates and technology data, we find that a ZNE building requires ample PV capacity installed to ensure electricity sales during the day. This is complemented by investment in energy-efficient combined heat and power equipment, while occasional demand response shaves energy consumption. A large amount of storage is also adopted, which may be impractical. Nevertheless, it shows the nature of the solutions and costs necessary to achieve ZNE. For comparison, we analyze a nursing home facility in New York to examine the effects of a flatter tariff structure and different load profiles. It has trouble reaching ZNE status and its load reductions as well as efficiency measures need to be more effective than those in the CA case

  13. Emergency notification and assistance technical operations manual. Emergency preparedness and response. Date effective: 1 February 2007

    International Nuclear Information System (INIS)

    2007-01-01

    The Convention on Early Notification of a Nuclear Accident (the 'Early Notification Convention') and the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (the 'Assistance Convention') are the prime legal instruments that establish an international framework to facilitate the exchange of information and the prompt provision of assistance in the event of a nuclear or radiological emergency, with the aim of minimizing the consequences. The International Atomic Energy Agency has specific functions assigned to it under these Conventions, to which, in addition to a large number of States, the World Health Organization (WHO), the World Meteorological Organization (WMO) and the Food and Agriculture Organization of the United Nations (FAO) are full parties. The arrangements provided between the IAEA, States that are IAEA Member States and/or Parties to one or both Conventions, all other relevant international intergovernmental organizations, and other States for facilitating the implementation of these Conventions - specifically concerning those articles that are operational in nature - are documented in the Emergency Notification and Assistance Technical Operations Manual (ENATOM). ENATOM was first issued on 18 January 1989. Member States, Parties to the Early Notification and Assistance Conventions, relevant international organizations and other States have since then regularly received updates to the manual. In 2000, a complete revision of ENATOM was reissued as EPR-ENATOM (2000) to reflect technological developments, changes in operational concepts, views on standards in the area of emergency preparedness and response, and Member States' expectations. Since then ENATOM has been reviewed and reissued biennially in line with the review cycle of the Joint Radiation Emergency Management Plan of the International Organizations (the 'Joint Plan'). Since the last edition of ENATOM in 2004, several factors have warranted some modifications to

  14. Track-monitoring from the dynamic response of an operational train

    Science.gov (United States)

    Lederman, George; Chen, Siheng; Garrett, James; Kovačević, Jelena; Noh, Hae Young; Bielak, Jacobo

    2017-03-01

    We explore a data-driven approach for monitoring rail infrastructure from the dynamic response of a train in revenue-service. Presently, track inspection is performed either visually or with dedicated track geometry cars. In this study, we examine a more economical approach where track inspection is performed by analyzing vibration data collected from an operational passenger train. The high frequency with which passenger trains travel each section of track means that faults can be detected sooner than with dedicated inspection vehicles, and the large number of passes over each section of track makes a data-driven approach statistically feasible. We have deployed a test-system on a light-rail vehicle and have been collecting data for the past two years. The collected data underscores two of the main challenges that arise in train-based track monitoring: the speed of the train at a given location varies from pass to pass and the position of the train is not known precisely. In this study, we explore which feature representations of the data best characterize the state of the tracks despite these sources of uncertainty (i.e., in the spatial domain or frequency domain), and we examine how consistently change detection approaches can identify track changes from the data. We show the accuracy of these different representations, or features, and different change detection approaches on two types of track changes, track replacement and tamping (a maintenance procedure to improve track geometry), and two types of data, simulated data and operational data from our test-system. The sensing, signal processing, and data analysis we propose in the study could facilitate safer trains and more cost-efficient maintenance in the future. Moreover, the proposed approach is quite general and could be extended to other parts of the infrastructure, including bridges.

  15. Emergency notification and assistance technical operations manual. Emergency preparedness and response. Date effective: 1 December 2002

    International Nuclear Information System (INIS)

    2002-11-01

    The Convention on Early Notification of a Nuclear Accident (the 'Early Notification Convention') and the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (the 'Assistance Convention') are the prime legal instruments that establish an international framework to facilitate the exchange of information and the prompt provision of assistance in the event of a nuclear accident or radiological emergency, with the aim of minimizing their consequences. The International Atomic Energy Agency (IAEA) has specific functions assigned to it under these Conventions, to which, in addition to a large number of States (Section 1.7), the World Health Organization (WHO), the World Meteorological Organization (WMO) and the Food and Agriculture Organization of the United Nations (FAO) are full parties. The arrangements between the IAEA, States that are IAEA Member States and/or Parties to one or both Conventions, all other relevant international intergovernmental organizations, and other States for facilitating the implementation of these Conventions specifically concerning those articles that are operational in nature - are documented in the Emergency Notification and Assistance Technical Operations Manual (ENATOM). In 2000, a complete revision of ENATOM, with all relevant sections updated, withdrawn or replaced with new material, was reissued as EPR-ENATOM (2000) to reflect new technological developments, operational concepts, views on standards in the area of emergency preparedness and response, and Member States' expectations. A separate publication, EPR-JPLAN (2000), the Joint Radiation Emergency Management Plan of the International Organizations (Joint Plan'), described a common understanding of how each of six co-sponsoring international organizations will act during a response and in making preparedness arrangements. It is intended that the ENATOM is reviewed and reissued biennially in line with the review cycle of the Joint Plan. Since the

  16. Response

    Science.gov (United States)

    Hartman, Nancy C.

    1974-01-01

    Suggests more stringent use of task analysis in identifying and teaching reading subskills and the use of reinforcement contingencies which make it worthwhile for the child to tolerate frustration when teaching remedial reading to children with low frustration tolerance levels. (TO)

  17. Fetal Exposure to Moderate Ethanol Doses: Heightened Operant Responsiveness elicited by Ethanol-Related Reinforcers

    Science.gov (United States)

    March, Samanta M.; Abate, Paula; Spear, Norman E.; Molina, Juan Carlos

    2011-01-01

    Background Prenatal exposure to moderate ethanol doses during late gestation modifies postnatal ethanol palatability and ingestion. The use of Pavlovian associative procedures, has indicated that these prenatal experiences broaden the range of ethanol doses capable of supporting appetitive conditioning. Recently, a novel operant technique aimed at analyzing neonatal predisposition to gain access to ethanol has been developed. Experiment 1 tested the operant conditioning technique for developing rats described by Arias et al. (2007) and Bordner et al. (2008). In Experiment 2 we analyzed changes in the disposition to gain access to ethanol as a result of moderate prenatal exposure to the drug. Methods In Experiment 1 newborn pups were intraorally cannulated and placed in a supine position that allowed access to a touch-sensitive sensor. Paired pups received an intraoral administration of a given reinforcer (milk or quinine) contingent upon physical contact with the sensor. Yoked controls received similar reinforcers only when Paired pups activated the circuit. In Experiment 2, natural reinforcers (water or milk) as well as ethanol (3% or 6 % v/v) or an ethanol-related reinforcer (sucrose compounded with quinine) were tested. In this Experiment pups had been exposed to water or ethanol (1 or 2 g/kg) during gestational days 17–20. Results Experiment 1 confirmed previous results showing that 1-day-old pups rapidly learn an operant task to gain access to milk, but not to gain access to a bitter tastant. Experiment 2 showed that water and milk were highly reinforcing across prenatal treatments. Furthermore, general activity during training was not affected by prenatal exposure to ethanol. Most importantly, prenatal ethanol exposure facilitated conditioning when the reinforcer was 3% v/v ethanol or a psychophysical equivalent of ethanol’s gustatory properties (sucrose-quinine). Conclusions The present results suggest that late prenatal experience with ethanol changes

  18. Analyzing and Developing Corporate Social Responsibility practices of Kingshuk Co-operative Society Ltd. in Bangladesh

    OpenAIRE

    Islam, Aminul; Mazumder, Mohammad Alamgir Hossain

    2014-01-01

    Corporate Social Responsibility is gaining importance for all companies. Corporate Social Responsibly consists of social, economic, and environmental responsibilities. Green marketing, sustainability and ethics are added under Corporate Social Responsibility. The first objective of this research is to acquire an understanding of the concept of Corporate Social Responsibility with a focus on the diverse dimensions of Corporate Social Responsibility and understanding its effects in the context ...

  19. Understanding USSOCOM and US Marine Corps Roles in Crisis Response and Limited Contingency Operations

    Science.gov (United States)

    2013-04-15

    GOTHIC SERPENT) from Appendix A was a SOF lead manhunt operation in Somalia to capture a warlord named Mohamed Farrah Aidid that took the form of a...operations and the units that conducted them. First, none of the operations, with the exception of Operation GOTHIC SERPENT were catastrophic or highly... GOTHIC SERPENT 22-Aug-93 to 13-Oct-93 Somalia Limited Obj RAID – Manhunt Uncertain 160th SOAR(3) Delta Force (13) US Army Rangers (13) Seal Tm

  20. Kosovo Armed Forces Development; Achieving NATO Non-Article 5 Crisis Response Operations Interoperability

    Science.gov (United States)

    2014-12-12

    Intercultural Factors. ................................................................................................. 27 Allied Administrative...Multinational Military Operations and Intercultural Factors, NATO Standard Allied Administrative Publication (AAP) 47 Allied Joint Doctrine Development, NATO...standards for Peace Support Operations. NATO RTO Technical Report Multinational Military Operations and Intercultural Factors. NATO Research and

  1. Introduction of hypermatrix and operator notation into a discrete mathematics simulation model of malignant tumour response to therapeutic schemes in vivo. Some operator properties.

    Science.gov (United States)

    Stamatakos, Georgios S; Dionysiou, Dimitra D

    2009-10-21

    The tremendous rate of accumulation of experimental and clinical knowledge pertaining to cancer dictates the development of a theoretical framework for the meaningful integration of such knowledge at all levels of biocomplexity. In this context our research group has developed and partly validated a number of spatiotemporal simulation models of in vivo tumour growth and in particular tumour response to several therapeutic schemes. Most of the modeling modules have been based on discrete mathematics and therefore have been formulated in terms of rather complex algorithms (e.g. in pseudocode and actual computer code). However, such lengthy algorithmic descriptions, although sufficient from the mathematical point of view, may render it difficult for an interested reader to readily identify the sequence of the very basic simulation operations that lie at the heart of the entire model. In order to both alleviate this problem and at the same time provide a bridge to symbolic mathematics, we propose the introduction of the notion of hypermatrix in conjunction with that of a discrete operator into the already developed models. Using a radiotherapy response simulation example we demonstrate how the entire model can be considered as the sequential application of a number of discrete operators to a hypermatrix corresponding to the dynamics of the anatomic area of interest. Subsequently, we investigate the operators' commutativity and outline the "summarize and jump" strategy aiming at efficiently and realistically address multilevel biological problems such as cancer. In order to clarify the actual effect of the composite discrete operator we present further simulation results which are in agreement with the outcome of the clinical study RTOG 83-02, thus strengthening the reliability of the model developed.

  2. Emergency notification and assistance technical operations manual. Emergency preparedness and response. Date effective: 1 December 2000

    International Nuclear Information System (INIS)

    2000-11-01

    The Convention on Early Notification of a Nuclear Accident (the 'Early Notification Convention') and the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency (the 'Assistance Convention') are the prime legal instruments that establish an international framework to facilitate the exchange of information and the prompt provision of assistance in the event of a nuclear accident or radiological emergency, with the aim of minimizing the consequences. The International Atomic Energy Agency (IAEA) has specific functions assigned to it under these Conventions, to which the World Health Organization (WHO), the World Meteorological Organization (WMO) and the Food and Agriculture Organization of the United Nations (FAO) are full parties. Since 1989, the arrangements between the IAEA, States which are IAEA Member States and/or Parties to one or both Conventions, all other relevant international intergovernmental organizations, and other States for facilitating the implementation of the Conventions - specifically of those of their articles which are operational in nature have been documented in the Emergency Notification and Assistance Technical Operations Manual (ENATOM). Recent events, for example, the launch of the Cassini satellite (USA, 1997), the Acerinox accident (Spain, 1998), the JCO criticality accident (Japan, 1999), the Istanbul accident (Turkey, 1999) and the Samut Prakarn accident (Thailand, 2000), have raised new issues and highlighted the expectation of States that the IAEA will use the framework of the Early Notification and Assistance Conventions to obtain and provide real-time emergency related information on such events. While the Early Notification Convention requires States Parties to report only accidents that may have significant transboundary radiological consequences, States may under the Assistance Convention legitimately request the assistance of the IAEA or an Accident State in obtaining information concerning a

  3. A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve

    KAUST Repository

    Yi, Ying

    2015-07-22

    Implantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve\\'s closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.

  4. Ten-year response of a forest bird community to an operational herbicide-shelterwood treatment in Allegheny hardwoods

    Science.gov (United States)

    Scott H. Stoleson; Todd E. Ristau; David S. deCalesta; Stephen B. Horsley

    2011-01-01

    Use of herbicides in forestry to direct successional trajectories has raised concerns over possible direct or indirect effects on non-target organisms. We studied the response of forest birds to an operational application of glyphosate and sulfometuron methyl herbicides, using a randomized block design in which half of each 8 ha block received herbicide and the other...

  5. Evaluation of the risk to underground mine personnel due to the rockmass response to continuous mining operations.

    CSIR Research Space (South Africa)

    Van Aswegen, G

    2001-11-01

    Full Text Available The objective of the study was to determine whether there is a difference in the seismic response of the rockmass between 11-day mining cycle and full calendar operations - FULCO. A literature survey was useful to gain insight in the time dependent...

  6. Introduction of Hypermatrix and Operator Notation into a Discrete Mathematics Simulation Model of Malignant Tumour Response to Therapeutic Schemes In Vivo. Some Operator Properties

    Directory of Open Access Journals (Sweden)

    Georgios S. Stamatakos

    2009-10-01

    Full Text Available The tremendous rate of accumulation of experimental and clinical knowledge pertaining to cancer dictates the development of a theoretical framework for the meaningful integration of such knowledge at all levels of biocomplexity. In this context our research group has developed and partly validated a number of spatiotemporal simulation models of in vivo tumour growth and in particular tumour response to several therapeutic schemes. Most of the modeling modules have been based on discrete mathematics and therefore have been formulated in terms of rather complex algorithms (e.g. in pseudocode and actual computer code. However, such lengthy algorithmic descriptions, although sufficient from the mathematical point of view, may render it difficult for an interested reader to readily identify the sequence of the very basic simulation operations that lie at the heart of the entire model. In order to both alleviate this problem and at the same time provide a bridge to symbolic mathematics, we propose the introduction of the notion of hypermatrix in conjunction with that of a discrete operator into the already developed models. Using a radiotherapy response simulation example we demonstrate how the entire model can be considered as the sequential application of a number of discrete operators to a hypermatrix corresponding to the dynamics of the anatomic area of interest. Subsequently, we investigate the operators’ commutativity and outline the “summarize and jump” strategy aiming at efficiently and realistically address multilevel biological problems such as cancer. In order to clarify the actual effect of the composite discrete operator we present further simulation results which are in agreement with the outcome of the clinical study RTOG 83–02, thus strengthening the reliability of the model developed.

  7. Future Opportunities and Challenges with Using Demand Response as a Resource in Distribution System Operation and Planning Activities

    Energy Technology Data Exchange (ETDEWEB)

    Cappers, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); MacDonald, Jason [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Page, Janie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Potter, Jennifer [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Stewart, Emma [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-01-01

    This scoping study focuses on identifying the ability for current and future demand response opportunities to contribute to distribution system management. To do so, this scoping study will identify the needs of a distribution system to operate efficiently, safely and reliably; summarize both benefits and challenges for the operation of the distribution system with high penetration levels of distributed energy resources; define a suite of services based on those changing operational needs that could be provided by resources; identify existing demand response opportunities sponsored by distribution utilities and/or aggregators of retail customers; assess the extent to which distribution system services can be provided via DR opportunities both in their current form and with alterations to their design; and provide a qualitative assessment of coordination issues that bulk power and distribution system providers of DR opportunities will need to address.

  8. Radiological and pathological response following pre-operative radiotherapy for soft-tissue sarcoma

    International Nuclear Information System (INIS)

    Roberge, David; Skamene, Tanya; Nahal, Ayoub; Turcotte, Robert E.; Powell, Tom; Freeman, Carolyn

    2010-01-01

    Purpose: To report radiological and pathological response to neo-adjuvant radiotherapy for extremity and trunk soft-tissue sarcomas. Materials/methods: Fifty patients were identified retrospectively. All patients had MRI imaging pre and post neo-adjuvant external beam radiotherapy. Tumor volumes were measured in 3D on T1 Gadolinium enhanced sequences. Pathological treatment response was quantified in terms of percentage of treatment-related necrosis for each case. Results: Histopathologic responses to treatment varied from 0% to 100%. The median pathological treatment response was 67.5% for low-grade sarcomas and 50% for high-grade sarcomas. The median decrease in tumor volume was 13.8% for non-myxoid low-grade sarcomas, 82.1% for myxoid liposarcomas and <1% for high-grade sarcomas. A partial response on MRI (volume reduction ≥ 50%) was highly predictive of a good pathological response (p < 0.001). Patients with stable disease on imaging or volumetric progression had wide ranging pathological responses. Conclusions: Soft-tissue sarcomas show significant pathological treatment responses in the form of hyaline fibrosis, necrosis and granulation tissue. Despite this, there is minimal early volumetric response to radiation, especially for high-grade tumors. Although radiological partial response was predictive of pathological response, the significance of radiological progression was unclear. Myxoid liposarcoma tumor type was predictive of both pathological and radiological tumor response.

  9. Transient temperature response of in-vessel components due to pulsed operation in tokamak fusion experimental reactor (FER)

    International Nuclear Information System (INIS)

    Minato, Akio; Tone, Tatsuzo

    1985-12-01

    A transient temperature response of the in-vessel components (first wall, blanket, divertor/limiter and shielding) surrounding plasma in Tokamak Fusion Experimental Reactor (FER) has been analysed. Transient heat load during start up/shut down and pulsed operation cycles causes the transient temperature response in those components. The fatigue lifetime of those components significantly depends upon the resulting cyclic thermal stress. The burn time affects the temperature control in the solid breeder (Li 2 O) and also affects the thermo-mechanical design of the blanket and shielding which are constructed with thick structure. In this report, results of the transient temperature response obtained by the heat transfer and conduction analyses for various pulsed operation scenarios (start up, shut down, burn and dwell times) have been investigated in view of thermo-mechanical design of the in-vessel components. (author)

  10. Resourcing for Special Operations Forces (SOF): Should Responsibilities be Passed from USSOCOM Back to the Services?

    National Research Council Canada - National Science Library

    Lane, William R

    2006-01-01

    ...) was transferred from the service departments to U.S. Special Operations Command (USSOCOM) following the legislation mandating the creation of a unified combatant command for SOF and the establishment of USSOCOM...

  11. Corporate responsibility, beyond voluntarism : regulatory options to reinforce the licence to operate

    NARCIS (Netherlands)

    Eijsbouts, J.

    2011-01-01

    Inaugural Lecture Delivered in an informal and abbreviated form at the acceptance of the appointment of Extraordinary Professor Corporate Social Responsibility at the Faculty of Law, Maastricht University

  12. A bi-level integrated generation-transmission planning model incorporating the impacts of demand response by operation simulation

    International Nuclear Information System (INIS)

    Zhang, Ning; Hu, Zhaoguang; Springer, Cecilia; Li, Yanning; Shen, Bo

    2016-01-01

    Highlights: • We put forward a novel bi-level integrated power system planning model. • Generation expansion planning and transmission expansion planning are combined. • The effects of two sorts of demand response in reducing peak load are considered. • Operation simulation is conducted to reflect the actual effects of demand response. • The interactions between the two levels can guarantee a reasonably optimal result. - Abstract: If all the resources in power supply side, transmission part, and power demand side are considered together, the optimal expansion scheme from the perspective of the whole system can be achieved. In this paper, generation expansion planning and transmission expansion planning are combined into one model. Moreover, the effects of demand response in reducing peak load are taken into account in the planning model, which can cut back the generation expansion capacity and transmission expansion capacity. Existing approaches to considering demand response for planning tend to overestimate the impacts of demand response on peak load reduction. These approaches usually focus on power reduction at the moment of peak load without considering the situations in which load demand at another moment may unexpectedly become the new peak load due to demand response. These situations are analyzed in this paper. Accordingly, a novel approach to incorporating demand response in a planning model is proposed. A modified unit commitment model with demand response is utilized. The planning model is thereby a bi-level model with interactions between generation-transmission expansion planning and operation simulation to reflect the actual effects of demand response and find the reasonably optimal planning result.

  13. On the fast response of charnel electron multipliers in coUnting mode operation

    International Nuclear Information System (INIS)

    Belyaevskij, O.A.; Gladyshev, I.L.; Korobochko, Yu.S.; Mineev, V.I.

    1983-01-01

    Dependences of amplitude distribution of pulses at the outlet of channel electron multipliers (CEM) and effectiveness of monitoring on counting rate at different supply voltages are determined. It is shown that the maximUm counting rate of CEM runs into 6x10 5 s -1 at short-term and 10 5 s -1 at long-term operation using monitoring eqUipment with operation threshold of 2.5 mV

  14. The Responsibilities of the Scientist in International Understanding, Co-Operation, Peace, and Human Rights.

    Science.gov (United States)

    Voinea, Radu; Pascu, Ioan Mircea

    1984-01-01

    A discussion of the responsibility of scientists as repositories of knowledge, as educators, and as citizens outlines some concerns of the scientific community for problems of peace and disarmament. It is noted that a recent common awareness of a common responsibility for society is evident in the intensity of scientific contacts. (MSE)

  15. Operating Characteristics of Six Response Distortion Indicators for the Personality Assessment Inventory.

    Science.gov (United States)

    Morey, Leslie C.; Lanier, V. Whitson

    1998-01-01

    Characteristics of six different indicators of response distortion on the Personality Assessment Inventory (PAI) (L. Morey, 1991) were evaluated by having 134 college students complete the PAI under positive impression management, malingering, and honest responding conditions. All six indicators could distinguish actual and feigned responses. (SLD)

  16. Maximum likelihood estimation of dose-response parameters for therapeutic operating characteristic (TOC) analysis of carcinoma of the nasopharynx

    International Nuclear Information System (INIS)

    Metz, C.E.; Tokars, R.P.; Kronman, H.B.; Griem, M.L.

    1982-01-01

    A Therapeutic Operating Characteristic (TOC) curve for radiation therapy plots, for all possible treatment doses, the probability of tumor ablation as a function of the probability of radiation-induced complication. Application of this analysis to actual therapeutic situation requires that dose-response curves for ablation and for complication be estimated from clinical data. We describe an approach in which ''maximum likelihood estimates'' of these dose-response curves are made, and we apply this approach to data collected on responses to radiotherapy for carcinoma of the nasopharynx. TOC curves constructed from the estimated dose-response curves are subject to moderately large uncertainties because of the limitations of available data.These TOC curves suggest, however, that treatment doses greater than 1800 rem may substantially increase the probability of tumor ablation with little increase in the risk of radiation-induced cervical myelopathy, especially for T1 and T2 tumors

  17. Does the Future Engineer Force Transition Engineer Units between Offensive and Stability Operations in Ways That Achieve Responsiveness, Versatility, Agility, Effectiveness, and Efficiency?

    National Research Council Canada - National Science Library

    London, David T

    2005-01-01

    .... The main question is as follows: Does the FEF transition engineer units between offensive and stability operations in ways that achieve responsiveness, versatility, agility, effectiveness, and efficiency...

  18. Designing for a safe response to operational and severe accident initiators in the Integral Fast Reactor

    International Nuclear Information System (INIS)

    Vilim, R.B.

    1994-01-01

    A method is described for optimizing the plant control strategy for a liquid metal reactor with respect to safety margins sustained in unprotected upset events. The optimization is performed subject to the normal requirements for reactor startup, load change and compensation for reactivity changes over the cycle. The method provides a formal approach to the process of exploiting the innate self-regulating property of a metal fueled reactor to make it less dependent on operator action and less vulnerable to automatic control system fault and/or operator error

  19. Mobile Detection Assessment and Response Systems (MDARS): A Force Protection, Physical Security Operational Success

    National Research Council Canada - National Science Library

    Shoop, Brian; Johnston, Michael; Goehring, Richard; Moneyhun, Jon; Skibba, Brian

    2006-01-01

    ... & barrier assessment payloads. Its functions include surveillance, security, early warning, incident first response and product and barrier status primarily focused on a depot/munitions security mission at structured/semi-structured facilities...

  20. Operation TOMODACHI: A Model for American Disaster Response Efforts and the Collective use of Military Forces Abroad

    Science.gov (United States)

    2012-01-01

    Gen Burton Field (Yokota AB, Japan), March 2011 2 Knight, Bill, Colonel, 374 AW/CV, et. al ., “Operation TOMODACHI, MAF Response to Japan’s Nuclear...was best described by the 459th Airlift Squadron Commander, Lt Col Eugene “Gene” Capone during an interview after the completion of mapping efforts...12 Capone , Eugene, Lt Col, 459 AS/CC, personal interview with Dr. John Treiber, transcribed by Dr. John Treiber

  1. Water and Climate Impacts on Power System Operations: The Importance of Cooling Systems and Demand Response Measures

    Energy Technology Data Exchange (ETDEWEB)

    Macknick, Jordan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhou, Ella [National Renewable Energy Lab. (NREL), Golden, CO (United States); O' Connell, Matthew [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brinkman, Gregory [National Renewable Energy Lab. (NREL), Golden, CO (United States); Miara, Ariel [City College of New York, NY (United States); Ibanez, Eduardo [GE Energy Connections, Atlanta, GA (United States); Hummon, Marissa [Tendril, Denver, CO (United States)

    2016-12-01

    The U.S. electricity sector is highly dependent upon water resources; changes in water temperatures and water availability can affect operational costs and the reliability of power systems. Despite the importance of water for power system operations, the effects of changes in water characteristics on multiple generators in a system are generally not modeled. Moreover, demand response measures, which can change the magnitude and timing of loads and can have beneficial impacts on power system operations, have not yet been evaluated in the context of water-related power vulnerabilities. This effort provides a first comprehensive vulnerability and cost analysis of water-related impacts on a modeled power system and the potential for demand response measures to address vulnerability and cost concerns. This study uniquely combines outputs and inputs of a water and power plant system model, production cost, model, and relative capacity value model to look at variations in cooling systems, policy-related thermal curtailments, and demand response measures to characterize costs and vulnerability for a test system. Twenty-five scenarios over the course of one year are considered: a baseline scenario as well as a suite of scenarios to evaluate six cooling system combinations, the inclusion or exclusion of policy-related thermal curtailments, and the inclusion or exclusion of demand response measures. A water and power plant system model is utilized to identify changes in power plant efficiencies resulting from ambient conditions, a production cost model operating at an hourly scale is used to calculate generation technology dispatch and costs, and a relative capacity value model is used to evaluate expected loss of carrying capacity for the test system.

  2. Comparison of the Effect of Noise Levels on Stress Response in Two Different Operation Groups in an Orthopedic Surgery Room

    Directory of Open Access Journals (Sweden)

    Hasibe Baytan Yildiz

    2016-09-01

    Full Text Available Aim: The aim of this randomized, single-blinded study was to evaluate the effects of noise on hemodynamic and neuroendocrine stress response by measuring the level of noise in the surgery rooms of patients undergoing knee operations under neuroaxial anesthesia. Gerec ve Yontem: We compared patient responses from two groups of patients: those undergoing knee operations in a surgery room where the noise level (measured in decibels is high, and those undergoing meniscus operations in a surgery room with lower noise levels. The STAI, the State-Trait Anxiety Inventory (STAI-1, and the anxiety test (STAI-2wereperformed at preoperative and postoperative periods. 20 ml of blood sample was taken for basal, intraoperative 30th minute, and postoperative 1st hour measurements. Systolic, diastolic, and mean arterial blood pressures were found to be higher in the high noise level group. ACTH levels were increased during the early postoperative period and became normal during the late postoperative period in the high noise level group whereas ACTH levels were significantly decreased in the low-noise level group. Basal cortisol levels were significantly higher in the high noise level group. HCRP, an inflammatory response mediator was found to be decreased in both groups. Early and late blood glucose levels were significantly higher in the high noise group. There was a greater increase in early and late blood glucose levels in the high noise group. In the postoperative period, although the state-trait anxiety inventory (STAI-2 levels being higher in patients subject to noisier environment determines how people feel independent of the conditions and state they are in, this result made us consider that the noise the patients were subjected to in the intraoperative period may cause a stress response. Discussion: As a result we believe that standard noise levels should be achieved by reducing the factors causing high noise levels in the operating room. This will

  3. Do Surgeons React?: A Retrospective Analysis of Surgeons' Response to Harassment of a Colleague During Simulated Operating Theatre Scenarios.

    Science.gov (United States)

    Gostlow, Hannah; Vega, Camila Vega; Marlow, Nicholas; Babidge, Wendy; Maddern, Guy

    2017-07-24

    To assess and report on surgeons' ability to identify and manage incidences of harassment. The Royal Australasian College of Surgeons is committed to driving out discrimination, bullying, harassment, and sexual harassment from surgical training and practice, through changing the culture of the workplace. To eradicate these behaviors, it is first critical to understand how the current workforce responds to these actions. A retrospective analysis of video data of an operating theatre simulation was conducted to identify how surgeons, from a range of experience levels, react to instances of harassment. Thematic analysis was used to categorize types of harassment and participant response characteristics. The frequency of these responses was assessed and reported. The type of participant response depended on the nature of harassment being perpetuated and the seniority of the participant. In the 50 instances of scripted harassment, active responses were enacted 52% of the time, acknowledgment responses 16%, and no response enacted in 30%. One senior surgeon also perpetuated the harassment (2%). Trainees were more likely to respond actively compared with consultants. It is apparent that trainees are more aware of instances of harassment, and were more likely to intervene during the simulated scenario. However, a large proportion of harassment was unchallenged. The hierarchical nature of surgical education and the surgical workforce in general needs to enable a culture in which the responsibility to intervene is allowed and respected. Simulation-based education programs could be developed to train in the recognition and intervention of discrimination, bullying, harassment and sexual harassment.

  4. 28 CFR 25.53 - Responsibilities of the operator of NMVTIS.

    Science.gov (United States)

    2010-07-01

    ... reporting and other requirements, and sufficient detail and scope regarding financial information so that...) NMVTIS shall permit a user of the system to establish instantly and reliably: (1) The validity and status... users of NMVTIS must be approved by the Department of Justice. (f) The operator shall biennially...

  5. Occupant Responses and Office Work Performance in Environments with Moderately Drifting Operative Temperatures (RP-1269)

    DEFF Research Database (Denmark)

    Kolarik, Jakub; Toftum, Jørn; Olesen, Bjarne W.

    2009-01-01

    , proofreading, reading and comprehension, and text typing. Results of the experiments showed that even moderately changing operative temperature ramps were sensed by sedentary subjects when exposure times exceeded 4 h. No significant effects on SBS symptoms related to local irritation of mucous membranes were...

  6. Automatic diagnosis of alarms: a system to improve operator emergency response

    International Nuclear Information System (INIS)

    Olson, H.P.; Gimmy, K.L.; Nomm, E.; Finley, R.H.

    1980-01-01

    A system is being developed at the Savannah River Plant to help reactor operators respond to multiple alarms in a developing incident situation. The need for such systems has becme evident in recent years, particularly after the Three Mile Island incident

  7. 78 FR 13268 - Passenger Vessel Operator Financial Responsibility Requirements for Nonperformance of Transportation

    Science.gov (United States)

    2013-02-27

    ... passenger vessel operators could have a significant economic impact on a substantial number of small... Regulatory Flexibility Act, 5 U.S.C. 601 et seq., that the Final Rule will not have a significant economic..., Inc., MP Ferrymar, Inc., American Classic, Royal Olympic, Regal Cruises, Ocean Club Cruise Line...

  8. An atomic force microscope operating at hypergravity for in situ measurement of cellular mechano-response

    NARCIS (Netherlands)

    van Loon, J.J.W.A.; van Laar, M.C.; Korterik, J.P.; Segerink, F.B.; Wubbels, R.J.; de Jong, H.A.A.; van Hulst, N.F.

    2009-01-01

    We present a novel atomic force microscope (AFM) system, operational in liquid at variable gravity, dedicated to image cell shape changes of cells in vitro under hypergravity conditions. The hypergravity AFM is realized by mounting a stand-alone AFM into a large-diameter centrifuge. The balance

  9. Supplement analysis for continued operation of Lawrence Livermore National Laboratory and Sandia National Laboratories, Livermore. Volume 2: Comment response document

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The US Department of Energy (DOE), prepared a draft Supplement Analysis (SA) for Continued Operation of Lawrence Livermore National Laboratory (LLNL) and Sandia National Laboratories, Livermore (SNL-L), in accordance with DOE`s requirements for implementation of the National Environmental Policy Act of 1969 (NEPA) (10 Code of Federal Regulations [CFR] Part 1021.314). It considers whether the Final Environmental Impact Statement and Environmental Impact Report for Continued Operation of Lawrence Livermore National Laboratory and Sandia National Laboratories, Livermore (1992 EIS/EIR) should be supplement3ed, whether a new environmental impact statement (EIS) should be prepared, or no further NEPA documentation is required. The SA examines the current project and program plans and proposals for LLNL and SNL-L, operations to identify new or modified projects or operations or new information for the period from 1998 to 2002 that was not considered in the 1992 EIS/EIR. When such changes, modifications, and information are identified, they are examined to determine whether they could be considered substantial or significant in reference to the 1992 proposed action and the 1993 Record of Decision (ROD). DOE released the draft SA to the public to obtain stakeholder comments and to consider those comments in the preparation of the final SA. DOE distributed copies of the draft SA to those who were known to have an interest in LLNL or SNL-L activities in addition to those who requested a copy. In response to comments received, DOE prepared this Comment Response Document.

  10. Method to generate generic floor response spectra for operating nuclear power plant

    International Nuclear Information System (INIS)

    Curreri, J.; Costantino, C.; Subudhi, M.; Reich, M.

    1985-01-01

    The general approach in the development of the response spectra was to study the effects on the dynamic characteristics of each of the elements in the chain of events that goes between the loads and the responses. This includes the loads, the soils and the structures. A free-field earthquake response spectra was used to generate horizontal earthquake time histories. The excitation was applied through the soil and into the various structures to produce responses in equipment. An entire range of soil conditions was used with each structure, from soft soil to solid rock. Actual PWR and BWR - Mark I structural models were used as representative of a class of structures. For each model, the stiffness properties were varied, with the same mass, so as to extend the fundamental base structure natural frequency from 2 cps to 36 cps. This resulted in fundamental mode coupled natural frequencies as low as 0.86 cps and as high as 30 cps. From all of these models of soils and structures, floor response spectra were generated at each floor level. The natural frequencies of the structures were varied to obtain maximum response conditions. The actual properties were first used to locate the natural frequencies. The stiffness properties were then varied, with the same mass, to extend the range of the fundamental base structure natural frequency. The intention was to have the coupled structural material frequencies in the vicinity of the peak amplitude frequency content of the excitation spectrum. Particular attention was therefore given to the frequency band between 2 Hz and 4 Hz. A horizontal generic floor response spectra is proposed for the top level of a generic structure. Reduction factors are applied to the peak acceleration for equipment at lower levels

  11. A method to generate generic floor response spectra for operating nuclear power plants

    International Nuclear Information System (INIS)

    Curreri, J.; Costantino, C.; Subudhi, M.; Reich, M.

    1985-01-01

    A free-field earthquake response spectra was used to generate horizontal earthquake time histories. The excitation was applied through the soil and into the various structures to produce responses in equipment. An entire range of soil conditions was used with each structure, from soft soil to solid rock. Actual PWR and BWR - Mark I structural models were used as representative of a class of structures. For each model, the stiffness properties were varied, with the same mass, so as to extend the fundamental base structure natural frequency from 2 cps to 36 cps. This resulted in fundamental mode coupled natural frequencies as low as 0.86 cps and as high as 30 cps. From all of these models of soils and structures, floor response spectra were generated at each floor level. The natural frequencies of the structures were varied to obtain maximum response conditions. The actual properties were first used to locate the natural frequencies. The stiffness properties were than varied, with the same mass, to extend the range of the fundamental base structure natural frequency. The intention was to have the coupled structural material frequencies in the vicinity of the peak amplitude frequency content of the excitation spectrum. Particular attention was therefore given to the frequency band between 2 Hz and 4 Hz. A horizontal generic floor response spectra is proposed for the top level of a generic structure. Reduction factors are applied to the peak acceleration for equipment at lower levels. (orig./HP)

  12. Vibration response of the waste rock dump in open pit mine caused by blasting operation

    OpenAIRE

    Markéta Lednická; Zdeněk Kaláb

    2015-01-01

    Analysis of slope stability is often solved when designing and realizing waste dumps. Vibration effect needs to be taken into account, especially when the waste dump is situated in close distance to the seismic loading source. In the open pit mine near Jarnoltowek (Poland), phyllite is excavated, and rock waste is deposited on the dump directly in the mine; that is at a distance of approximately 150 m from the quarry face. Blasting operations are used as mining technology here so the...

  13. Vibration response of waste rock dump in open pit mine caused by blasting operation

    OpenAIRE

    Lednická, M. (Markéta); Kaláb, Z. (Zdeněk)

    2015-01-01

    In the open pit mine near Jarnoltowek (Poland), phyllite is excavated and rock waste is deposited on the dump directly in the mine; that is at a distance of approximately 150 m from the quarry face. Blasting operations are used as mining technology here so the rock waste dump could be influenced by these vibrations significantly. The paper presents results of experimental seismological measurement performed on four levels of the rock waste dump in the discussed mine.

  14. 29 CFR 1910.120 - Hazardous waste operations and emergency response.

    Science.gov (United States)

    2010-07-01

    ... water-borne vessel. Hazardous materials response (HAZMAT) team means an organized group of employees, designated by the employer, who are expected to perform work to handle and control actual or potential leaks... test equipment (i.e., combustible gas meters, detector tubes) for IDLH and other conditions that may...

  15. 29 CFR 1926.65 - Hazardous waste operations and emergency response.

    Science.gov (United States)

    2010-07-01

    ... consumer product in consumer use or any water-borne vessel. Hazardous materials response (HAZMAT) team... handle and control actual or potential leaks or spills of hazardous substances requiring possible close... test equipment (i.e., combustible gas meters, detector tubes) for IDLH and other conditions that may...

  16. 78 FR 38023 - Demand Response Supporters v. New York Independent System Operator, Inc.; Notice of Complaint

    Science.gov (United States)

    2013-06-25

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL13-74-000] Demand Response... Practice and Procedure of the Federal Energy Regulatory Commission (Commission), 18 CFR 385.206, Demand..., Inc. (NYISO or Respondents), seeking an order requiring NYISO to amend its tariffs to allow demand...

  17. Recent developments in the applications of the Regional Atmospheric Modeling System (RAMS) for emergency response planning and operational forecasting at the Kennedy Space Center

    International Nuclear Information System (INIS)

    Lyons, W.A.; Tremback, C.J.

    1996-01-01

    The authors will summarize ten years of developing and applying the Regional Atmospheric Modeling System (RAMS) to emergency response and operational dispersion forecasting at the Kennedy Space Center (KSC). RAMS forms the core of two workstation-based operational systems, ERDAS (the Emergency Response Dose Assessment System) and PROWESS (Parallelized RAMS Operational Weather Simulation System) which are undergoing extensive operational testing prior to potential deployment as part of the range forecasting system at KSC. RAMS has been interfaced with HYPACT (the Hybrid Particle and Concentration Transport Model) to produce detailed 3-D dispersion forecasts from a variety of sources including cold spills, routine launch operations, and explosive conflagrations of launch vehicles

  18. Corrective economic dispatch and operational cycles for probabilistic unit commitment with demand response and high wind power

    International Nuclear Information System (INIS)

    Azizipanah-Abarghooee, Rasoul; Golestaneh, Faranak; Gooi, Hoay Beng; Lin, Jeremy; Bavafa, Farhad; Terzija, Vladimir

    2016-01-01

    Highlights: • Suggesting a new UC mixing a probabilistic security and incentive demand response. • Investigating the effects of uncertainty on UC using chance-constraint programming. • Proposing an efficient spinning reserve satisfaction based on a new ED correction. • Presenting a new operational cycles way to convert binary variable to discrete one. - Abstract: We propose a probabilistic unit commitment problem with incentive-based demand response and high level of wind power. Our novel formulation provides an optimal allocation of up/down spinning reserve. A more efficient unit commitment algorithm based on operational cycles is developed. A multi-period elastic residual demand economic model based on the self- and cross-price elasticities and customers’ benefit function is used. In the proposed scheme, the probability of residual demand falling within the up/down spinning reserve imposed by n − 1 security criterion is considered as a stochastic constraint. A chance-constrained method, with a new iterative economic dispatch correction, wind power curtailment, and commitment of cheaper units, is applied to guarantee that the probability of loss of load is lower than a pre-defined risk level. The developed architecture builds upon an improved Jaya algorithm to generate feasible, robust and optimal solutions corresponding to the operational cost. The proposed framework is applied to a small test system with 10 units and also to the IEEE 118-bus system to illustrate its advantages in efficient scheduling of generation in the power systems.

  19. Multi-response optimization of diesel engine operating parameters running with water-in-diesel emulsion fuel

    Directory of Open Access Journals (Sweden)

    Vellaiyan Suresh

    2017-01-01

    Full Text Available Water-in-diesel emulsion fuel is a promising alternative diesel fuel, which has the potential to promote better performance and emission characteristics in an existing Diesel engine without engine modification and added cost. The key factor that has to be focused with the introduction of such fuel in existing Diesel engine is desired engine-operating conditions. The present study attempts to address the previous issue with two-phases of experiments. In the first phase, stable water-in-diesel emulsion fuels (5, 10, 15, and 20 water-in-diesel are prepared and their stability period and physico-chemical properties are measured. In the second phase, experiments are conducted in a single cylinder, 4-stroke Diesel engine with pre-pared water-in-diesel emulsion fuel blends based on L16 orthogonal array suggested in Taguchi’s quality control concept to record the output responses (perormance and emission levels. Based on signal-to-noise ratio and grey relational analysis, optimal level of operating factors are determined to obtain better response and verified through confirmation experiments. A statistical analysis of variance is applied to measure the significance of individual operating parameters on overall engine performance. Results indicate that the emulsion fuel prepared by Sorbitan monolaurate surfactant at high stirrer speed endows with better emulsion stability and acceptable variation in physicochemical properties. Results of this study also reveal that the optimal parametric setting effectively improves the combustion, performance, and emission characteristics of Diesel engine.

  20. Expanding the toolbox for studying the biological responses of individual fish to hydropower infrastructure and operating strategies

    International Nuclear Information System (INIS)

    Hasler, C.T.; Cooke, S.J.; Patterson, D.A.

    2009-01-01

    Hydropower infrastructure and the operational strategies used by power utilities have the potential to change local aquatic environments. However, few studies have evaluated sub-organismal responses such as physiological consequences of individual fish to fluctuating flows or hydropower infrastructure such as fishways or turbines. Rather than review the impacts of hydropower on fish, this paper detailed the behavioural, energetic, genomic, molecular, forensic, isotopic, and physiological tools available for studying sub-organismal responses of fish to hydropower infrastructure and operating procedures with a critical assessment of their benefits and limitations. A brief summary of the current state of knowledge regarding the 12 types of tools was provided along with their usefulness in fisheries science and environmental management. The benefits and limitations of using these techniques for evaluating hydropower impacts on fish and fish habitat were discussed. Two case studies were presented to demonstrate how the inclusion of individual-based information into hydropower research has helped to improve the understanding of complex fish and hydropower issues. Practitioners can use the expanded toolbox to assess fishway performance, migration delays, and fish responses to fluctuating flows through a mechanistic approach. These tools are also relevant for evaluating other anthropogenic impacts such as water withdrawal for irrigation or drinking water, habitat alteration, and fisheries interactions. The expanded toolbox can contribute to a more sustainable hydropower industry by providing regulators with tools for making informed decisions and evaluating compliance issues. 150 refs., 1 tab., 4 figs

  1. Influence of the control bars pattern on the response of the operation channels of the TRIGA Mark III reactor

    International Nuclear Information System (INIS)

    Paredes G, L.C.

    1991-07-01

    The local flow perturbations not generated by movements of bars not planned adequately to operate the reactor to 1 MW of thermal power, are reflected in the independent responses of the operation channels of the same one, find variations average from 17% to 30% for the channel of the power percent and of until 10% for the logarithmic channel. For the case of the lineal and percent power channels, these are between 14% and 46% as maximum when moving some of the bars. These variations can diminish until 5% in the channel of the power percent and until 3% on the average for the logarithmic one, all times when the calculated bars pattern for that irradiation considers that all the bars operate inside the lineal region of its calibration curve with approximately the same reactivity value each one and that during the operation the required reactivity compensations are carried out with the diametrically opposed bar to the irradiation installation used in that experiment. (Author)

  2. Response Load Extrapolation for Wind Turbines during Operation Based on Average Conditional Exceedance Rates

    DEFF Research Database (Denmark)

    Toft, Henrik Stensgaard; Naess, Arvid; Saha, Nilanjan

    2011-01-01

    within a hierarchical model where the variables that influence the loading are divided into ergodic variables and time-invariant non-ergodic variables. The presented method for statistical response load extrapolation was compared with the existing methods based on peak extrapolation for the blade out...... to cases where the Gumbel distribution is the appropriate asymptotic extreme value distribution. However, two extra parameters are introduced by which a more general and flexible class of extreme value distributions is obtained with the Gumbel distribution as a subclass. The general method is implemented...

  3. Load kick-back effects due to activation of demand response in view of distribution grid operation

    DEFF Research Database (Denmark)

    Han, Xue; Sossan, Fabrizio; Bindner, Henrik W.

    2014-01-01

    There are increasing potentials to utilize the flexibilities from demand side resource (DSR) units. They can provide grid operation services by shifting or curtailing their energy consumption. The service provision can be achieved by aggregating a large quantity of DSR units in the network....... The paper has shown how aggregated consumption dynamics introduce new peaks in the system due to the synchronous behaviors of a portfolio of homogeneous DSRs, which is instructed by the flexibility management system. This dynamic effect is recognized as load kick-back effect. The impact of load kick......-back effects onto the distribution grid is analysed in this paper by establishing scenarios based on the estimation of DSR penetration levels from the system operator. The results indicate some risks that the activation of demand response may create critical peaks in the local grid due to kick-back effects....

  4. Benthic foraminiferal responses to operational drill cutting discharge in the SW Barents Sea - a case study.

    Science.gov (United States)

    Aagaard-Sørensen, Steffen; Junttila, Juho; Dijkstra, Noortje

    2016-04-01

    Petroleum related exploration activities started in the Barents Sea 1980, reaching 97 exploration wells drilled per January 2013. The biggest operational discharge from drilling operations in the Barents Sea is the release of drill cuttings (crushed seabed and/or bedrock) and water based drilling muds including the commonly used weighing material barite (BaSO4). Barium (Ba), a constituent of barite, does not degrade and can be used to evaluate dispersion and accumulation of drill waste. The environmental impact associated with exploration drilling within the Goliat Field, SW Barents Sea in 2006 was evaluated via a multiproxy investigation of local sediments. The sediments were retrieved in November 2014 at ~350 meters water depth and coring sites were selected at distances of 5, 30, 60, 125 and 250 meters from the drill hole in the eastward downstream direction. The dispersion pattern of drill waste was estimated via measurements of sediment parameters including grain size distribution and water content in addition to heavy metal and total organic carbon contents. The environmental impact was evaluated via micro faunal analysis based on benthic foraminiferal (marine shell bearing protists) fauna composition and concentration changes. Observing the sediment parameters, most notably Ba levels, reveals that dispersion of drill waste was limited to <125 meters from the drill site with drill waste thicknesses decreasing downstream. The abruptness and quantity of drill waste sedimentation initially smothered the foraminiferal fauna at ≤ 30 meters from the drill site, while at a distance of 60 meters, the fauna seemingly survived and bioturbation persisted. Analysis of the live (Nov 2014) foraminiferal fauna reveals a natural species composition at all distances from the drill site within the top sediments (0-5 cm core depth). Furthermore, the fossil foraminiferal fauna composition found within post-impacted top sediment sections, particularly in the cores situated at

  5. Bus operators' responses to job strain: An experimental test of the job demand-control model.

    Science.gov (United States)

    Cendales-Ayala, Boris; Useche, Sergio Alejandro; Gómez-Ortiz, Viviola; Bocarejo, Juan Pablo

    2017-10-01

    The research aim was to test the Job Demand-Control (JDC) Model demands × Control interaction (or buffering) hypothesis in a simulated bus driving experiment. The buffering hypothesis was tested using a 2 (low and high demands) × 2 (low and high decision latitude) design with repeated measures on the second factor. A sample of 80 bus operators were randomly assigned to the low (n = 40) and high demands (n = 40) conditions. Demands were manipulated by increasing or reducing the number of stops to pick up passengers, and decision latitude by imposing or removing restrictions on the Rapid Transit Bus (BRT) operators' pace of work. Outcome variables include physiological markers (heart rate [HR], heart rate variability [HRV], breathing rate [BR], electromyography [EMG], and skin conductance [SC]), objective driving performance and self-report measurements of psychological wellbeing (psychological distress, interest/enjoyment [I/E], perceived competence, effort/importance [E/I], and pressure/tension [P/T]). It was found that job decision latitude moderates the effect of job demands on both physiological arousal (BR: F(1, 74) = 4.680, p = .034, SC: F(1, 75) = 6.769, p = .011, and EMG: F(1, 75) = 6.550, p = .013) and psychological well-being (P/T: F(1, 75) = 4.289, p = .042 and I/E: F(1, 74) = 4.548, p = .036). Consistently with the JDC model buffering hypothesis, the experimental findings suggest that increasing job decision latitude can moderate the negative effect of job demands on different psychophysiological outcomes. This finding is useful for designing organizational and clinical interventions in an occupational group at high risk of work stress-related disease. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  6. The position of a standard optical computer mouse affects cardiorespiratory responses during the operation of a computer under time constraints

    Directory of Open Access Journals (Sweden)

    Shunji Sako

    2014-08-01

    Full Text Available Objectives: This study investigated the association between task-induced stress and fatigue by examining the cardiovascular responses of subjects using different mouse positions while operating a computer under time constraints. Material and Methods: The study was participated by 16 young, healthy men and examined the use of optical mouse devices affixed to laptop computers. Two mouse positions were investigated: (1 the distal position (DP, in which the subjects place their forearms on the desk accompanied by the abduction and flexion of their shoulder joints, and (2 the proximal position (PP, in which the subjects place only their wrists on the desk without using an armrest. The subjects continued each task for 16 min. We assessed differences in several characteristics according to mouse position, including expired gas values, autonomic nerve activities (based on cardiorespiratory responses, operating efficiencies (based on word counts, and fatigue levels (based on the visual analog scale – VAS. Results: Oxygen consumption (VO2, the ratio of inspiration time to respiration time (Ti/Ttotal, respiratory rate (RR, minute ventilation (VE, and the ratio of expiration to inspiration (Te/Ti were significantly lower when the participants were performing the task in the DP than those obtained in the PP. Tidal volume (VT, carbon dioxide output rates (VCO2/VE, and oxygen extraction fractions (VO2/VE were significantly higher for the DP than they were for the PP. No significant difference in VAS was observed between the positions; however, as the task progressed, autonomic nerve activities were lower and operating efficiencies were significantly higher for the DP than they were for the PP. Conclusions: Our results suggest that the DP has fewer effects on cardiorespiratory functions, causes lower levels of sympathetic nerve activity and mental stress, and produces a higher total workload than the PP. This suggests that the DP is preferable to the PP when

  7. The production and operation of the nuclear industry road emergency response plan (NIREP)

    International Nuclear Information System (INIS)

    Higson, J.

    1991-01-01

    For many years, radioactive material, ranging from small sources used for medical and commercial purposes to large consignments of irradiated fuel, has been safely moved by road in Great Britain. All such movements are controlled by law and have to meet clearly specified safety requirements concerning packaging and shielding to ensure that if the transporting vehicle is involved in an accident, there is no increase in the hazards involved because of the nature of its load. There are currently some 40,000 movements by road every year, but over more than 25 years, there has never been an accident which has led to any significant radiological impact to members of the public. A national scheme to provide contingency arrangements in the event of a road accident involving radioactive materials has now been set up by the major users and consignors of radioactive material. Called NIREP (Nuclear Industry Road Emergency Response Plan), the member industries have agreed immediately to despatch, from the nearest organisation to the incident, qualified health physicist personnel to deal with any incident involving radioactive material belonging to (or consigned by) any of the participating companies. With their widespread location of establishments, all parts of the UK mainland are covered. Vehicles covered by the scheme will display a NIREP placard, thus giving the Police, or other emergency services, an emergency telephone number of a coordinating centre and information on the site responsible for the load. (author)

  8. Synthesis of well-defined alkyne terminated poly(N-vinyl caprolactam) with stringent control over the LCST by RAFT.

    Science.gov (United States)

    Góis, Joana R; Costa, João R C; Popov, Anatoliy V; Serra, Arménio C; Coelho, Jorge F J

    The reversible addition-fragmentation chain transfer (RAFT) of N -vinyl caprolactam (NVCL) using two new xanthates with alkyne functionalities is reported. The kinetic data obtained for polymerization of this non-activated monomer using a protected alkyne-terminated RAFT agent (PAT-X 1 ) revealed a linear increase of the polymer molecular weight with the monomer conversion as well as low dispersity ( Đ ) during the entire course of the polymerization. The system reported here allowed us to enhance the final conversion, diminish Đ and reduce the polymerization temperature compared to the typical values reported in the scarce literature available for the RAFT polymerization of NVCL. The resulting PNVCL was fully characterized using 1 H nuclear magnetic resonance ( 1 H NMR), matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), Fourier-transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC) techniques. The temperature-responsive features of PNVCL in aqueous solutions were fully investigated under different conditions using turbidimetry. The presented strategy allows the synthesis of well-defined PNVCL with sharp and reversible phase transition temperatures around 37 °C. By manipulating the polymer molecular weight, or the solution properties, it is possible to tune the PNVCL phase transition. As a proof-of concept, the alkyne functionalized PNVCL was used to afford new linear block copolymers, by reacting with an azide-terminated poly(ethylene glycol) (N 3 -PEG) through the copper catalyzed azide-alkyne [3+2] dipolar cycloaddition (CuAAC) reaction. The results presented establish a robust system to afford the synthesis of PNCVL with fine tuned characteristics that will enable more efficient exploration of the remarkable potential of this polymer in biomedical applications.

  9. Implementing and operating the Hanford Environmental Information System and applying it to the carbon tetrachloride expedited response action

    International Nuclear Information System (INIS)

    Cowley, P.J.; Last, G.V.; Schwab, M.R.; Rohay, V.J.

    1993-02-01

    To manage waste and perform environmental monitoring and restoration at the 1450-square kilometer (560-square mile) Hanford Site in southeastern Washington State, vast amounts of scientific and technical data are being generated from sampling. This paper provides an overview of the Hanford Environmental Information System (HEIS), a computerized system designed and implemented to manage the Site's environmental sampling data, lessons learned from putting HEIS into operation, and how HEIS is being applied to the carbon tetrachloride expedited response action being performed at the Site

  10. pOp6/LhGR: a stringently regulated and highly responsive dexamethasone-inducible gene expression system for tobacco

    Czech Academy of Sciences Publication Activity Database

    Šámalová, Markéta; Brzobohatý, Břetislav; Moore, Ian

    2005-01-01

    Roč. 41, - (2005), s. 919-935 ISSN 0960-7412 R&D Projects: GA AV ČR(CZ) IAA5004001; GA AV ČR(CZ) KSK5052113 Institutional research plan: CEZ:AV0Z50040507 Keywords : chemically inducible gene expression * cytokinin-biosynthetic gene ipt * tobacco Subject RIV: BO - Biophysics Impact factor: 6.969, year: 2005

  11. Use of the RoboFlag synthetic task environment to investigate workload and stress responses in UAV operation.

    Science.gov (United States)

    Guznov, Svyatoslav; Matthews, Gerald; Funke, Gregory; Dukes, Allen

    2011-09-01

    Use of unmanned aerial vehicles (UAVs) is an increasingly important element of military missions. However, controlling UAVs may impose high stress and workload on the operator. This study evaluated the use of the RoboFlag simulated environment as a means for profiling multiple dimensions of stress and workload response to a task requiring control of multiple vehicles (robots). It tested the effects of two workload manipulations, environmental uncertainty (i.e., UAV's visual view area) and maneuverability, in 64 participants. The findings confirmed that the task produced substantial workload and elevated distress. Dissociations between the stress and performance effects of the manipulations confirmed the utility of a multivariate approach to assessment. Contrary to expectations, distress and some aspects of workload were highest in the low-uncertainty condition, suggesting that overload of information may be an issue for UAV interface designers. The strengths and limitations of RoboFlag as a methodology for investigating stress and workload responses are discussed.

  12. Salient features, response and operation of Lead-Free Gulmarg Neutron Monitor

    International Nuclear Information System (INIS)

    Mufti, S.; Chatterjee, S.; Ishtiaq, P.M.; Darzi, M.A.; Mir, T.A.; Shah, G.N.

    2016-01-01

    Lead-Free Gulmarg Neutron Monitor (LFGNM) provides continuous ground level intensity measurements of atmospheric secondary neutrons produced in interactions of primary cosmic rays with the Earth's constituent atmosphere. We report the LFGNM detector salient features and simulation of its energy response for 10 −11 MeV to 10 4 MeV energy incident neutrons using the FLUKA Monte Carlo package. An empirical calibration of the LFGNM detector carried out with a Pu–Be neutron source for maximising its few MeV neutron counting sensitivity is also presented. As an illustration of its functionality a single representative transient solar modulation event recorded by LFGNM depicting Forbush decrease in integrated neutron data for which the geospace consequences are well known is also presented. Performance of LFGNM under actual observation conditions for effectively responding to transient solar modulation is seen to compare well with other world-wide conventional neutron monitors.

  13. Salient features, response and operation of Lead-Free Gulmarg Neutron Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Mufti, S., E-mail: mufti.sabiuddin@gmail.com [Astrophysical Sciences Division, Nuclear Research Laboratory, Bhabha Atomic Research Centre, Srinagar - 190 006 (India); Chatterjee, S. [TLD Unit, Variable Energy Cyclotron Centre, Bhabha Atomic Research Centre, 1/AF-Bidhannagar, Kolkata - 700 064 (India); Ishtiaq, P.M.; Darzi, M.A.; Mir, T.A.; Shah, G.N. [Astrophysical Sciences Division, Nuclear Research Laboratory, Bhabha Atomic Research Centre, Srinagar - 190 006 (India)

    2016-03-21

    Lead-Free Gulmarg Neutron Monitor (LFGNM) provides continuous ground level intensity measurements of atmospheric secondary neutrons produced in interactions of primary cosmic rays with the Earth's constituent atmosphere. We report the LFGNM detector salient features and simulation of its energy response for 10{sup −11} MeV to 10{sup 4} MeV energy incident neutrons using the FLUKA Monte Carlo package. An empirical calibration of the LFGNM detector carried out with a Pu–Be neutron source for maximising its few MeV neutron counting sensitivity is also presented. As an illustration of its functionality a single representative transient solar modulation event recorded by LFGNM depicting Forbush decrease in integrated neutron data for which the geospace consequences are well known is also presented. Performance of LFGNM under actual observation conditions for effectively responding to transient solar modulation is seen to compare well with other world-wide conventional neutron monitors.

  14. Work responsability evaluation of a nuclear power plant operator during an emergency event

    International Nuclear Information System (INIS)

    Silva, Nilo Garcia da

    2002-01-01

    In this work, a method to evaluate the Man - Machine Interface, using the Model of Human Process utilized by the Combustion Engineer-CE was used in the Licensing Process of a Nuclear Power Plant, applying methodology in the emergency procedure of a SGTR for Angra 1 NPP. The time needed for the operators to perform the tasks step by step in this procedure was calculated. This time was compared to that found in the GOMS model, by which it is possible to perform an evaluation of workload for this accident. The criteria of the Standard ANSI/58.8-1994 was used to establish the reaction and execution times for these tasks. Practical measures in a Angra 2 NPP full scope simulator were done some steps of the SGTR emergency procedure. The time evaluation in the GOMS model has identified that three was a concentration of tasks, with the execution time near the limits regulated in the Standard above as compared with the times from the CE methodology. Finally, after a comparison of the results from Angra 1 and Angra 2, recommendations were done to the Angra 1 NPP utility in order to improve these identified points. (author)

  15. Memory and the operational witness: Police officer recall of firearms encounters as a function of active response role.

    Science.gov (United States)

    Hope, Lorraine; Blocksidge, David; Gabbert, Fiona; Sauer, James D; Lewinski, William; Mirashi, Arta; Atuk, Emel

    2016-02-01

    Investigations after critical events often depend on accurate and detailed recall accounts from operational witnesses (e.g., law enforcement officers, military personnel, and emergency responders). However, the challenging, and often stressful, nature of such events, together with the cognitive demands imposed on operational witnesses as a function of their active role, may impair subsequent recall. We compared the recall performance of operational active witnesses with that of nonoperational observer witnesses for a challenging simulated scenario involving an armed perpetrator. Seventy-six police officers participated in pairs. In each pair, 1 officer (active witness) was armed and instructed to respond to the scenario as they would in an operational setting, while the other (observer witness) was instructed to simply observe the scenario. All officers then completed free reports and responded to closed questions. Active witnesses showed a pattern of heart rate activity consistent with an increased stress response during the event, and subsequently reported significantly fewer correct details about the critical phase of the scenario. The level of stress experienced during the scenario mediated the effect of officer role on memory performance. Across the sample, almost one-fifth of officers reported that the perpetrator had pointed a weapon at them although the weapon had remained in the waistband of the perpetrator's trousers throughout the critical phase of the encounter. These findings highlight the need for investigator awareness of both the impact of operational involvement and stress-related effects on memory for ostensibly salient details, and reflect the importance of careful and ethical information elicitation techniques. PsycINFO Database Record (c) 2016 APA, all rights reserved.

  16. Achieving stringent climate targets. An analysis of the role of transport and variable renewable energies using energy-economy-climate models

    Energy Technology Data Exchange (ETDEWEB)

    Pietzcker, Robert Carl

    2014-07-01

    Anthropogenic climate change is threatening the welfare of mankind. Accordingly, policy makers have repeatedly stated the goal of slowing climate change and limiting the increase of global mean temperature to less than 2 C above pre-industrial times (the so-called ''two degree target''). Stabilizing the temperature requires drastic reductions of greenhouse gas (GHG) emissions to nearly zero. As the global system of energy supply currently relies on fossil fuels, reducing GHG emissions can only be achieved through a full-scale transformation of the energy system. This thesis investigates the economic requirements and implications of different scenarios that achieve stringent climate mitigation targets. It starts with the analysis of characteristic decarbonization patterns and identifies two particularly relevant aspects of mitigation scenarios: deployment of variable renewable energies (VRE) and decarbonization of the transport sector. After investigating these fields in detail, we turned towards one of the most relevant questions for policy makers and analyzed the trade-off between the stringency of a climate target and its economic requirements and implications. All analyses are based on the improvement, application, comparison, and discussion of large-scale IAMs. The novel ''mitigation share'' metric allowed us to identify the relevance of specific technology groups for mitigation and to improve our understanding of the decarbonization patterns of different energy subsectors. It turned out that the power sector is decarbonized first and reaches lowest emissions, while the transport sector is slowest to decarbonize. For the power sector, non-biomass renewable energies contribute most to emission reductions, while the transport sector strongly relies on liquid fuels and therefore requires biomass in combination with carbon capture and sequestration (CCS) to reduce emissions. An in-depth investigation of the solar power

  17. Modeling of the Reactor Core Isolation Cooling Response to Beyond Design Basis Operations - Interim Report

    Energy Technology Data Exchange (ETDEWEB)

    Ross, Kyle [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cardoni, Jeffrey N. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wilson, Chisom Shawn [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Morrow, Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Osborn, Douglas [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gauntt, Randall O. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-12-01

    Efforts are being pursued to develop and qualify a system-level model of a reactor core isolation (RCIC) steam-turbine-driven pump. The model is being developed with the intent of employing it to inform the design of experimental configurations for full-scale RCIC testing. The model is expected to be especially valuable in sizing equipment needed in the testing. An additional intent is to use the model in understanding more fully how RCIC apparently managed to operate far removed from its design envelope in the Fukushima Daiichi Unit 2 accident. RCIC modeling is proceeding along two avenues that are expected to complement each other well. The first avenue is the continued development of the system-level RCIC model that will serve in simulating a full reactor system or full experimental configuration of which a RCIC system is part. The model reasonably represents a RCIC system today, especially given design operating conditions, but lacks specifics that are likely important in representing the off-design conditions a RCIC system might experience in an emergency situation such as a loss of all electrical power. A known specific lacking in the system model, for example, is the efficiency at which a flashing slug of water (as opposed to a concentrated jet of steam) could propel the rotating drive wheel of a RCIC turbine. To address this specific, the second avenue is being pursued wherein computational fluid dynamics (CFD) analyses of such a jet are being carried out. The results of the CFD analyses will thus complement and inform the system modeling. The system modeling will, in turn, complement the CFD analysis by providing the system information needed to impose appropriate boundary conditions on the CFD simulations. The system model will be used to inform the selection of configurations and equipment best suitable of supporting planned RCIC experimental testing. Preliminary investigations with the RCIC model indicate that liquid water ingestion by the turbine

  18. Assessing postdisaster psychological stress in hazardous waste operations and emergency response (HAZWOPER) workers.

    Science.gov (United States)

    Calcote, Joshua C; Carson, Arch I; Peskin, Melissa F; Emery, Robert J

    2013-10-01

    To assess the prevalence of traumatic stress experienced by secondary responders to disaster events to determine if mental health education should be included in HAZWOPER training. Preexisting survey tools for assessing posttraumatic stress disorder (PTSD), resiliency, and mental distress were combined to form a web-based survey tool that was distributed to individuals functioning in secondary response roles. Data were analyzed using the Fisher exact test, 1-way ANOVA, and 1-sample t tests. Respondents reported elevated PTSD levels (32.9%) as compared to the general population. HAZWOPER-trained responders with disaster work experience were more likely to be classified as PTSD positive as compared to untrained, inexperienced responders and those possessing only training or experience. A majority (68.75%) scored below the mean resiliency level of 80.4 on the Connor-Davidson Resilience Scale. Respondents with only training or both training and experience were more likely to exhibit lower resiliency scores than those with no training or experience. PTSD positivity correlated with disaster experience. Among respondents, 91% indicated support for mental health education. Given the results of the survey, consideration should be given to the inclusion of pre- and postdeployment mental health education in the HAZWOPER training regimen.

  19. Human operator response to error-likely situations in complex engineering systems

    Science.gov (United States)

    Morris, Nancy M.; Rouse, William B.

    1988-01-01

    The causes of human error in complex systems are examined. First, a conceptual framework is provided in which two broad categories of error are discussed: errors of action, or slips, and errors of intention, or mistakes. Conditions in which slips and mistakes might be expected to occur are identified, based on existing theories of human error. Regarding the role of workload, it is hypothesized that workload may act as a catalyst for error. Two experiments are presented in which humans' response to error-likely situations were examined. Subjects controlled PLANT under a variety of conditions and periodically provided subjective ratings of mental effort. A complex pattern of results was obtained, which was not consistent with predictions. Generally, the results of this research indicate that: (1) humans respond to conditions in which errors might be expected by attempting to reduce the possibility of error, and (2) adaptation to conditions is a potent influence on human behavior in discretionary situations. Subjects' explanations for changes in effort ratings are also explored.

  20. On the Influence of Operational and Control Parameters in Thermal Response Testing of Borehole Heat Exchangers

    Directory of Open Access Journals (Sweden)

    Borja Badenes

    2017-09-01

    Full Text Available Thermal response test (TRT is a common procedure for characterization of ground and borehole thermal properties needed for the design of a shallow geothermal heat pump system. In order to investigate and to develop more accurate and robust procedures for TRT control, modelling, and evaluation in semi-permeable soils with large water content, a pilot borehole heat exchanger was built in the main campus of the Universitat Politècnica de València. The present work shows the results of the experiments performed at the site, analysing the improvements that have been introduced both in the control of the heat injected during TRTs and in the methods to infer the ground thermal parameter. Three models are compared: two based on the infinite-line source theory and one based on the finite-line source scheme. The models were tested under two possible configurations of the equipment, i.e., with and without strict control of injected heat. Our results show the importance of heat injection control for a robust parameter assessment and the existence of additional heat transfer processes that the used models cannot completely characterize and that are related to the presence of significant groundwater flow at the site. In addition, our experience with the current installation and the knowledge about its strengths and weaknesses have allowed us to design a new and more complete test-site to help in the analysis and validation of new ground heat exchanger geometries.

  1. Pandemic controllability: a concept to guide a proportionate and flexible operational response to future influenza pandemics.

    Science.gov (United States)

    McCaw, J M; Glass, K; Mercer, G N; McVernon, J

    2014-03-01

    The 2009 H1N1 influenza pandemic posed challenges for governments worldwide. Strategies designed to limit community transmission, such as antiviral deployment, were largely ineffective due to both feasibility constraints and the generally mild nature of disease, resulting in incomplete case ascertainment. Reviews of national pandemic plans have identified pandemic impact, primarily linked to measures of transmissibility and severity, as a key concept to incorporate into the next generation of plans. While an assessment of impact provides the rationale under which interventions may be warranted, it does not directly provide an assessment on whether particular interventions may be effective. Such considerations motivate our introduction of the concept of pandemic controllability. For case-targeted interventions, such as antiviral treatment and post-exposure prophylaxis, we identify the visibility and transmissibility of a pandemic as the key drivers of controllability. Taking a case-study approach, we suggest that high-impact pandemics, for which control is most desirable, are likely uncontrollable with case-targeted interventions. Strategies that do not rely on the identification of cases may prove relatively more effective. By introducing a pragmatic framework for relating the assessment of impact to the ability to mitigate an epidemic (controllability), we hope to address a present omission identified in pandemic response plans.

  2. Stringent and reproducible tetracycline-regulated transgene expression by site-specific insertion at chromosomal loci with pre-characterised induction characteristics

    Directory of Open Access Journals (Sweden)

    Papanastasiou Antigoni M

    2007-05-01

    Full Text Available Abstract Background The ability to regulate transgene expression has many applications, mostly concerning the analysis of gene function. Desirable induction characteristics, such as low un-induced expression, high induced expression and limited cellular heterogeneity, can be seriously impaired by chromosomal position effects at the site of transgene integration. Many clones may therefore need to be screened before one with optimal induction characteristics is identified. Furthermore, such screens must be repeated for each new transgene investigated, and comparisons between clones with different transgenes is complicated by their different integration sites. Results To circumvent these problems we have developed a "screen and insert" strategy in which clones carrying a transgene for a fluorescent reporter are first screened for those with optimal induction characteristics. Site-specific recombination (SSR is then be used repeatedly to insert any new transgene at the reporter transgene locus of such clones so that optimal induction characteristics are conferred upon it. Here we have tested in a human fibrosarcoma cell line (HT1080 two of many possible implementations of this approach. Clones (e.g. Rht14-10 in which a GFP reporter gene is very stringently regulated by the tetracycline (tet transactivator (tTA protein were first identified flow-cytometrically. Transgenes encoding luciferase, I-SceI endonuclease or Rad52 were then inserted by SSR at a LoxP site adjacent to the GFP gene resulting stringent tet-regulated transgene expression. In clone Rht14-10, increases in expression from essentially background levels (+tet to more than 104-fold above background (-tet were reproducibly detected after Cre-mediated insertion of either the luciferase or the I-SceI transgenes. Conclusion Although previous methods have made use of SSR to integrate transgenes at defined sites, none has effectively combined this with a pre-selection step to identify

  3. Proposal for the Development of an Economic Operator's Socially Responsible Management, by Manufacturing Metallic Objects for the Children's Play, both Outdoors and Indoors

    Directory of Open Access Journals (Sweden)

    Potincu L.

    2014-12-01

    Full Text Available This scientific paper intends to practically approach aspects related to socially responsible management by relating it to the activity of an economic operator manufacturing metal objects. The development of the socially responsible management is approached in relation to the responsibilities which are part of the corporate social responsibility concept (CSR. Thus, in our research, we have especially used juridical analysis methods and juridical proposals (de lege ferenda proposals, but also several elements belonging to other research fields.

  4. Historic and future trends of vehicle emissions in Beijing, 1998-2020: A policy assessment for the most stringent vehicle emission control program in China

    Science.gov (United States)

    Zhang, Shaojun; Wu, Ye; Wu, Xiaomeng; Li, Mengliang; Ge, Yunshan; Liang, Bin; Xu, Yueyun; Zhou, Yu; Liu, Huan; Fu, Lixin; Hao, Jiming

    2014-06-01

    As a pioneer in controlling vehicle emissions within China, Beijing released the Clean Air Action Plan 2013-2017 document in August 2013 to improve its urban air quality. It has put forward this plan containing the most stringent emission control policies and strategies to be adopted for on-road vehicles of Beijing. This paper estimates the historic and future trends and uncertainties in vehicle emissions of Beijing from 1998 to 2020 by applying a new emission factor model for the Beijing vehicle fleet (EMBEV). Our updated results show that total emissions of CO, THC, NOx and PM2.5 from the Beijing vehicle fleet are 507 (395-819) kt, 59.1 (41.2-90.5) kt, 74.7 (54.9-103.9) kt and 2.69 (1.91-4.17) kt, respectively, at a 95% confidence level. This represents significant reductions of 58%, 59%, 31% and 62%, respectively, relative to the total vehicle emissions in 1998. The past trends clearly posed a challenge to NOx emission mitigation for the Beijing vehicle fleet, especially in light of those increasing NOx emissions from heavy-duty diesel vehicles (HDDVs) which have partly offset the reduction benefit from light-duty gasoline vehicles (LDGVs). Because of recently announced vehicle emission controls to be adopted in Beijing, including tighter emissions standards, limitations on vehicle growth by more stringent license control, promotion of alternative fuel technologies (e.g., natural gas) and the scrappage of older vehicles, estimated vehicle emissions in Beijing will continue to be mitigated by 74% of CO, 68% of THC, 56% of NOx and 72% of PM2.5 in 2020 compared to 2010 levels. Considering that many of the megacities in China are facing tremendous pressures to mitigate emissions from on-road vehicles, our assessment will provide a timely case study of significance for policy-makers in China.

  5. Is Tc99m-MIBI scintigraphy a predictor of response to pre-operative neoadjuvant chemotherapy in Osteosarcoma?

    Directory of Open Access Journals (Sweden)

    Vahidreza Dabbagh Kakhki

    2013-10-01

    Full Text Available Objectives: Multidrug resistance (MDR, which may be due to the over expression of P-glycoprotein (Pgp and/or MRP, is a major problem in neoadjuvant chemotherapy of osteosarcoma. The aim of this study was to investigate the role of Tc-99m MIBI scan for predicting the response to pre-operative chemotherapy. Materials and Methods: Twenty-five patients (12 males and 13 females, aged between 8 and 52y with osteosarcoma were studied. Before the chemotherapy, planar 99mTc-MIBI anterior and posterior images were obtained 10-min [tumor-to-background ratio: (T1/B110min] and 3-hr after tracer injection. After completion of chemotherapy, again 99mTc-MIBI scan was performed at 10-min after tracer injection. In addition to calculation of decay corrected tumor to background (T/B ratios ,  using the 10-min and 3-hr images of the pre-chemotherapy scintigraphy , percent wash-out rate (WR% of 99mTc-MIBI was calculated. Using the 10-min images of the pre- and post-chemotherapy scans, the percent reduction in uptake at the tumor site after treatment (Red% was also calculated. Then after surgical resection, tumor response was assessed by percentage of necrosis. Results: All patients showed significant 99mTc-MIBI uptake in early images. Only 9 patients showed good response to chemotherapy (necrosis≥90% while 16 patients were considered as non-responder (necrosis

  6. Multi-response optimization and modeling of trim cut WEDM operation of commercially pure titanium (CPTi considering multiple user's preferences

    Directory of Open Access Journals (Sweden)

    Rupesh Chalisgaonkar

    2015-06-01

    Full Text Available In this research work, development of a multi response optimization technique has been undertaken, using traditional utility method in conjunction with the weight assignment concept (for multiple customer's priorities in trim cut wire electrical discharge machining (WEDM. Pure titanium has been selected as work material for experimentation. The effect of key process parameters such a wire type (zinc coated and uncoated brass wire, pulse on time (TON, pulse off time (TOFF, peak current (IP, wire feed (WF, servo voltage (SV and wire offset (WOFF were investigated on material removal rate (MRR, surface roughness and wire weight consumption (eroded weight of wire after machining in finish cut WEDM operation. Two different types of wire electrodes were taken for experimental research (uncoated, zinc coated. Further, the variation of the MRR was modeled semi-empirically through dimensional analysis. The developed model is mechanistic, as it can be used by the machinists to predict the MRR over a wide range of input parameters. The optimization of multiple responses has been done for satisfying the priorities of multiple users, in contrast to the traditional multi-response techniques where the optimized process setting is realized without giving any attention to the priorities of different users.

  7. Deciphering energy-associated gene networks operating in the response of Arabidopsis plants to stress and nutritional cues.

    Science.gov (United States)

    Avin-Wittenberg, Tamar; Tzin, Vered; Angelovici, Ruthie; Less, Hadar; Galili, Gad

    2012-06-01

    Plants need to continuously adjust their transcriptome in response to various stresses that lead to inhibition of photosynthesis and the deprivation of cellular energy. This adjustment is triggered in part by a coordinated re-programming of the energy-associated transcriptome to slow down photosynthesis and activate other energy-promoting gene networks. Therefore, understanding the stress-related transcriptional networks of genes belonging to energy-associated pathways is of major importance for engineering stress tolerance. In a bioinformatics approach developed by our group, termed 'gene coordination', we previously divided genes encoding for enzymes and transcription factors in Arabidopsis thaliana into three clusters, displaying altered coordinated transcriptional behaviors in response to multiple biotic and abiotic stresses (Plant Cell, 23, 2011, 1264). Enrichment analysis indicated further that genes controlling energy-associated metabolism operate as a compound network in response to stress. In the present paper, we describe in detail the network association of genes belonging to six central energy-associated pathways in each of these three clusters described in our previous paper. Our results expose extensive stress-associated intra- and inter-pathway interactions between genes from these pathways, indicating that genes encoding proteins involved in energy-associated metabolism are expressed in a highly coordinated manner. We also provide examples showing that this approach can be further utilized to elucidate candidate genes for stress tolerance and functions of isozymes. © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd.

  8. Estimation of Extreme Responses and Failure Probability of Wind Turbines under Normal Operation by Controlled Monte Carlo Simulation

    DEFF Research Database (Denmark)

    Sichani, Mahdi Teimouri

    by the indicated so-called crude Monte Carlo method. With failure probabilities of the magnitude 10−7 during a 10 min. sampling interval the tails of the distributions are never encountered during normal operations. To circumvent this problem the application of variance reduction Monte Carlo methods i...... an alternative approach for estimation of the first excursion probability of any system is based on calculating the evolution of the Probability Density Function (PDF) of the process and integrating it on the specified domain. Clearly this provides the most accurate results among the three classes of the methods......Extreme value predictions for application in wind turbine design are often based on asymptotic results. Assuming that the extreme values of a wind turbine responses, i.e. maximum values of the mud-line moment or blades’ root stress, follow a certain but unknown probability density (mass...

  9. Evaluation of the bioremoval of Cr(VI) and TOC in biofilters under continuous operation using response surface methodology.

    Science.gov (United States)

    Leles, Daniela M A; Lemos, Diego A; Filho, Ubirajara C; Romanielo, Lucienne L; de Resende, Miriam M; Cardoso, Vicelma L

    2012-06-01

    In the present study, the bioremoval of Cr(VI) and the removal of total organic carbon (TOC) were achieved with a system composed by an anaerobic filter and a submerged biofilter with intermittent aeration using a mixed culture of microorganisms originating from contaminated sludge. In the aforementioned biofilters, the concentrations of chromium, carbon, and nitrogen were optimized according to response surface methodology. The initial concentration of Cr(VI) was 137.35 mg l(-1), and a bioremoval of 85.23% was attained. The optimal conditions for the removal of TOC were 4 to 8 g l(-1) of sodium acetate, >0.8 g l(-1) of ammonium chloride and 60 to 100 mg l(-1) of Cr(VI). The results revealed that ammonium chloride had the strongest effect on the TOC removal, and 120 mg l(-1) of Cr(VI) could be removed after 156 h of operation. Moreover, 100% of the Cr(VI) and the total chromium content of the aerobic reactor output were removed, and TOC removals of 80 and 87% were attained after operating the anaerobic and aerobic reactors for 130 and 142 h, respectively. The concentrations of cells in both reactors remained nearly constant over time. The residence time distribution was obtained to evaluate the flow through the bioreactors.

  10. Operationally Responsive Tasking

    Science.gov (United States)

    2011-09-01

    policies set forth by parent organizations. Petitioners may be thought of as the reason for collecting intelligence and also the consumers of...convincing the gatekeeper firmly into the lap of the petitioners. It is this 37 need to convince an uninvolved party of the worthiness of a

  11. Satellite and Aerial Remote Sensing in Support of Disaster Response Operations Conducted by the Texas Division of Emergency Management

    Science.gov (United States)

    Wells, G. L.; Tapley, B. D.; Bettadpur, S. V.; Howard, T.; Porter, B.; Smith, S.; Teng, L.; Tapley, C.

    2014-12-01

    The effective use of remote sensing products as guidance to emergency managers and first responders during field operations requires close coordination and communication with state-level decision makers, incident commanders and the leaders of individual strike teams. Information must be tailored to meet the needs of different emergency support functions and must contain current (ideally near real-time) data delivered in standard formats in time to influence decisions made under rapidly changing conditions. Since 2003, a representative of the University of Texas Center for Space Research (CSR) has served as a member of the Governor's Emergency Management Council and has directed the flow of information from remote sensing observations and high performance computing modeling and simulations to the Texas Division of Emergency Management in the State Operations Center. The CSR team has supported response and recovery missions resulting from hurricanes, tornadoes, flash floods, wildfires, oil spills and other natural and man-made disasters in Texas and surrounding states. Through web mapping services, state emergency managers and field teams have received threat model forecasts, real-time vehicle tracking displays and imagery to support search-and-clear operations before hurricane landfall, search-and-rescue missions following floods, tactical wildfire suppression, pollution monitoring and hazardous materials detection. Data servers provide near real-time satellite imagery collected by CSR's direct broadcast receiving system and post data products delivered during activations of the United Nations International Charter on Space and Major Disasters. In the aftermath of large-scale events, CSR is charged with tasking state aviation resources, including the Air National Guard and Texas Civil Air Patrol, to acquire geolocated aerial photography of the affected region for wide area damage assessment. A data archive for each disaster is available online for years following

  12. Gulf of Mexico offshore operations monitoring experiment (GOOMEX), phase I : sublethal responses to contaminant exposure - introduction and overview

    International Nuclear Information System (INIS)

    Kennicutt, M.C.; Green, R.H.; Montagna, P.

    1996-01-01

    The Gulf of Mexico Offshore Operations Monitoring Experiment (GOOMEX) is a three-phase study to test and evaluate a range of biological, biochemical, and chemical methodologies to detect and assess chronic sublethal biological impacts in the vicinity of long-duration activities associated with oil and gas exploration and production. A chronic impact is defined as an effect on the biota caused by exposure to the long-term accumulation of chemicals in the environment. The basic program, comprising four field activities over a 2-yr period, was designed to detect nearfield impacts and contaminant gradients extending out from each site. Five test sites were evaluated and three selected as most appropriate for long-term study: MU-A85, MAI-686, and HI-A389. The sampling design included a radial pattern with stations at 30-50, 100, 200, 500, and 3000 m distance and employed a dose-response model to test the hypotheses that biological, chemical, and biochemical variations are due to platform-derived contaminants. Study components included contaminant (trace metals and hydrocarbons) analysis in sediments, pore waters, and biological tissues; assemblage analysis of benthic meiofauna, infauna, and epifauna, assessment of community health based on life history and reproduction studies; and the induction of detoxification responses. (author). 57 refs., 9 tabs., 5 figs

  13. Efficient Methods of Estimating the Operating Characteristics of Item Response Categories and Challenge to a New Model for the Multiple-Choice Item. Final Report.

    Science.gov (United States)

    Samejima, Fumiko

    In defense of retaining the "latent trait theory" term, instead of replacing it with "item response theory" as some recent research would have it, the following objectives are outlined: (1) investigation of theory and method for estimating the operating characteristics of discrete item responses using a minimum number of…

  14. Measuring behavioral responses of sea turtles, saltwater crocodiles, and crested terns to drone disturbance to define ethical operating thresholds.

    Science.gov (United States)

    Bevan, Elizabeth; Whiting, Scott; Tucker, Tony; Guinea, Michael; Raith, Andrew; Douglas, Ryan

    2018-01-01

    Drones are being increasingly used in innovative ways to enhance environmental research and conservation. Despite their widespread use for wildlife studies, there are few scientifically justified guidelines that provide minimum distances at which wildlife can be approached to minimize visual and auditory disturbance. These distances are essential to ensure that behavioral and survey data have no observer bias and form the basis of requirements for animal ethics and scientific permit approvals. In the present study, we documented the behaviors of three species of sea turtle (green turtles, Chelonia mydas, flatback turtles, Natator depressus, hawksbill turtles, Eretmochelys imbricata), saltwater crocodiles (Crocodylus porosus), and crested terns (Thalasseus bergii) in response to a small commercially available (1.4 kg) multirotor drone flown in Northern Territory and Western Australia. Sea turtles in nearshore waters off nesting beaches or in foraging habitats exhibited no evasive behaviors (e.g. rapid diving) in response to the drone at or above 20-30 m altitude, and at or above 10 m altitude for juvenile green and hawksbill turtles foraging on shallow, algae-covered reefs. Adult female flatback sea turtles were not deterred by drones flying forward or stationary at 10 m altitude when crawling up the beach to nest or digging a body pit or egg chamber. In contrast, flyovers elicited a range of behaviors from crocodiles, including minor, lateral head movements, fleeing, or complete submergence when a drone was present below 50 m altitude. Similarly, a colony of crested terns resting on a sand-bank displayed disturbance behaviors (e.g. flight response) when a drone was flown below 60 m altitude. The current study demonstrates a variety of behavioral disturbance thresholds for diverse species and should be considered when establishing operating conditions for drones in behavioral and conservation studies.

  15. A fast response oxygen sensor based upon a fully-sealed zirconia pump-gauge operated in the potentiometric mode

    Science.gov (United States)

    Benammar, M.; Maskell, W. C.

    1992-06-01

    An instrument for fast and continuous measurement of oxygen partial pressure not requiring a reference gas was constructed around a sealed zirconia oxygen pump-gauge sensor operated in the ac mode. By appropriate signal processing of the gauge EMF, the mean oxygen partial pressure within the sensor was determined and maintained constant via a feedback loop. Potentiometric measurement of the oxygen partial pressure in the sample gas was made relative to this controlled internal reference. The response time of the instrument for a step change in oxygen partial pressure from 1 to 10 kPa was only 65 ms. ned" OutputMedium="All"> 1 3 Proceedings of the 29th International Conference on the Applications of the Mössbauer Effect (ICAME 2007) held in Kanpur, India, 14-19 October 2007, PART IV/VII 30 2008 11 19 2008 11 18 2008 7 2008 Springer Science+Business Media B.V. 2008 9803 10.1007/s10751-008-9803-9 1 On the phenomena occurring at the interface between iron and iron–platinum thin films 1 7 2008 9 17 2008 10 10 Springer Science+Business Media B.V.

  16. Vestibulo-Ocular Responses to Vertical Translation using a Hand-Operated Chair as a Field Measure of Otolith Function

    Science.gov (United States)

    Wood, S. J.; Campbell, D. J.; Reschke, M. F.; Prather, L.; Clement, G.

    2016-01-01

    The translational Vestibulo-Ocular Reflex (tVOR) is an important otolith-mediated response to stabilize gaze during natural locomotion. One goal of this study was to develop a measure of the tVOR using a simple hand-operated chair that provided passive vertical motion. Binocular eye movements were recorded with a tight-fitting video mask in ten healthy subjects. Vertical motion was provided by a modified spring-powered chair (swopper.com) at approximately 2 Hz (+/- 2 cm displacement) to approximate the head motion during walking. Linear acceleration was measured with wireless inertial sensors (Xsens) mounted on the head and torso. Eye movements were recorded while subjects viewed near (0.5m) and far (approximately 4m) targets, and then imagined these targets in darkness. Subjects also provided perceptual estimates of target distances. Consistent with the kinematic properties shown in previous studies, the tVOR gain was greater with near targets, and greater with vision than in darkness. We conclude that this portable chair system can provide a field measure of otolith-ocular function at frequencies sufficient to elicit a robust tVOR.

  17. The development of Operational Intervention Levels (OILs) for Soils - A decision support tool in nuclear and radiological emergency response

    Science.gov (United States)

    Lee Zhi Yi, Amelia; Dercon, Gerd; Blackburn, Carl; Kheng, Heng Lee

    2017-04-01

    In the event of a large-scale nuclear accident, the swift implementation of response actions is imperative. For food and agriculture, it is important to restrict contaminated food from being produced or gathered, and to put in place systems to prevent contaminated produce from entering the food chain. Emergency tools and response protocols exist to assist food control and health authorities but they tend to focus on radioactivity concentrations in food products as a means of restricting the distribution and sale of contaminated produce. Few, if any, emergency tools or protocols focus on the food production environment, for example radioactivity concentrations in soils. Here we present the Operational Intervention Levels for Soils (OIL for Soils) concept, an optimization tool developed at the IAEA to facilitate agricultural decision making and to improve nuclear emergency preparedness and response capabilities. Effective intervention relies on the prompt availability of radioactivity concentration data and the ability to implement countermeasures. Sampling in food and agriculture can be demanding because it may involve large areas and many sample types. In addition, there are finite resources available in terms of manpower and laboratory support. Consequently, there is a risk that timely decision making will be hindered and food safety compromised due to time taken to sample and analyse produce. However, the OILs for Soils concept developed based on experience in Japan can help in this situation and greatly assist authorities responsible for agricultural production. OILs for Soils - pre-determined reference levels of air dose rates linked to radionuclide concentrations in soils - can be used to trigger response actions particularly important for agricultural and food protection. Key considerations in the development of the OILs for Soils are: (1) establishing a pragmatic sampling approach to prioritize and optimize available resources and data requirements for

  18. Will Precision Airdrop Capability Provide the Joint Force Commander with the Rapid Response Required for Tomorrow's Humanitarian Relief Operations?

    National Research Council Canada - National Science Library

    Witham, Randy L

    2007-01-01

    .... Precision direct delivery promises to slash in-transit time, minimize hub and spoke shuttle operations, reduce handling costs and save lives early in a relief operation before larger forces can arrive on scene...

  19. Final environmental impact statement for the continued operation of the Pantex Plant and associated storage of nuclear weapon components. Volume 3 -- Comment response

    International Nuclear Information System (INIS)

    1996-11-01

    The Draft Environmental Impact Statement (EIS) for the continued operation of Pantex Plant was published in March 1996. The document assessed the alternatives of no action, relocation of the storage of plutonium components resulting from nuclear weapon disassemble activities at Pantex Plant to another site, and the proposed action (preferred alternative) of continuing operations and increasing the quantity of pits in interim storage at Pantex Plant. This report contains the comments and responses received on the Draft EIS

  20. WARM JUPITERS NEED CLOSE ''FRIENDS'' FOR HIGH-ECCENTRICITY MIGRATION—A STRINGENT UPPER LIMIT ON THE PERTURBER'S SEPARATION

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Subo [Kavli Institute for Astronomy and Astrophysics, Peking University, Yi He Yuan Road 5, Hai Dian District, Beijing 100871 (China); Katz, Boaz; Socrates, Aristotle [Institute for Advanced Study, 1 Einstein Dr., Princeton, NJ 08540 (United States)

    2014-01-20

    We propose a stringent observational test on the formation of warm Jupiters (gas-giant planets with 10 days ≲ P ≲ 100 days) by high-eccentricity (high-e) migration mechanisms. Unlike hot Jupiters, the majority of observed warm Jupiters have pericenter distances too large to allow efficient tidal dissipation to induce migration. To access the close pericenter required for migration during a Kozai-Lidov cycle, they must be accompanied by a strong enough perturber to overcome the precession caused by general relativity, placing a strong upper limit on the perturber's separation. For a warm Jupiter at a ∼ 0.2 AU, a Jupiter-mass (solar-mass) perturber is required to be ≲ 3 AU (≲ 30 AU) and can be identified observationally. Among warm Jupiters detected by radial velocities (RVs), ≳ 50% (5 out of 9) with large eccentricities (e ≳ 0.4) have known Jovian companions satisfying this necessary condition for high-e migration. In contrast, ≲ 20% (3 out of 17) of the low-e (e ≲ 0.2) warm Jupiters have detected additional Jovian companions, suggesting that high-e migration with planetary perturbers may not be the dominant formation channel. Complete, long-term RV follow-ups of the warm-Jupiter population will allow a firm upper limit to be put on the fraction of these planets formed by high-e migration. Transiting warm Jupiters showing spin-orbit misalignments will be interesting to apply our test. If the misalignments are solely due to high-e migration as commonly suggested, we expect that the majority of warm Jupiters with low-e (e ≲ 0.2) are not misaligned, in contrast with low-e hot Jupiters.

  1. Inducible Expression of Agrobacterium Virulence Gene VirE2 for Stringent Regulation of T-DNA Transfer in Plant Transient Expression Systems.

    Science.gov (United States)

    Denkovskienė, Erna; Paškevičius, Šarūnas; Werner, Stefan; Gleba, Yuri; Ražanskienė, Aušra

    2015-11-01

    Agrotransfection with viral vectors is an effective solution for the transient production of valuable proteins in plants grown in contained facilities. Transfection methods suitable for field applications are desirable for the production of high-volume products and for the transient molecular reprogramming of plants. The use of genetically modified (GM) Agrobacterium strains for plant transfections faces substantial biosafety issues. The environmental biosafety of GM Agrobacterium strains could be improved by regulating their T-DNA transfer via chemically inducible expression of virE2, one of the essential Agrobacterium virulence genes. In order to identify strong and stringently regulated promoters in Agrobacterium strains, we evaluated isopropyl-β-d-thiogalactoside-inducible promoters Plac, Ptac, PT7/lacO, and PT5/lacOlacO and cumic acid-inducible promoters PlacUV5/CuO, Ptac/CuO, PT5/CuO, and PvirE/CuO. Nicotiana benthamiana plants were transfected with a virE2-deficient A. tumefaciens strain containing transient expression vectors harboring inducible virE2 expression cassettes and containing a marker green fluorescent protein (GFP) gene in their T-DNA region. Evaluation of T-DNA transfer was achieved by counting GFP expression foci on plant leaves. The virE2 expression from cumic acid-induced promoters resulted in 47 to 72% of wild-type T-DNA transfer. Here, we present efficient and tightly regulated promoters for gene expression in A. tumefaciens and a novel approach to address environmental biosafety concerns in agrobiotechnology.

  2. Response, Emergency Staging, Communications, Uniform Management, and Evacuation (R.E.S.C.U.M.E.) : Concept of Operations. [supporting datasets

    Science.gov (United States)

    2012-10-31

    This zip file contains 45 files of data to support FHWA-JPO-13-063 Response, Emergency Staging, Communications, Uniform Management, and Evacuation (R.E.S.C.U.M.E.) : Concept of Operations. Zip size is 9.9 MB. The files have been uploaded as-is; no fu...

  3. Low-visibility and night-time oil spill response operations; Operacoes noturnas e com baixa visibilidade em resposta a vazamentos com oleo

    Energy Technology Data Exchange (ETDEWEB)

    Lyra, Geraldo Marcelo Barroso; Margem, Henrique da Cunha; Skrepnek, Clarissa Cavalheiro; Lyra, Ana Paula Lopes Coelho de Castro; Silva, Ana Claudia Andriolli Vieira da; Antoun, Augusto Resende [Hidroclean Protecao Ambiental, Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The expansion on E and P area and the raise on importation and exportation activities by sea, cause not only commercial benefits, but also expressive environmental risks. This fact is reaffirmed by the actions of Brazilian environmental agencies in order to control potential polluter activities. However, these agencies are against any activity related to oil spill incidents that operate at night-time or during low-visibility condition because of the elevated risk of accidents on this kind of operation. In the other hand, delays on start response operation can be expensive by reducing recovery rates and increasing environmental impacts. Thus, this paper objective is to analyze studies and reports of night-time and low-visibility oil spill response operations occurred in other countries, concluding that when the right equipment is used, it is possible to start or continue oil spill operation independent of weather. However, before choose to start an operation at night, an assessment should be make to know if the risks outweigh the benefits, remarking that safety is always the primary concern. (author)

  4. Response, Emergency Staging, Communications, Uniform Management, and Evacuation (R.E.S.C.U.M.E.) : concept of operations.

    Science.gov (United States)

    2012-11-01

    The US DOT sponsored Dynamic Mobility Applications (DMA) program seeks to identify, develop, and deploy applications that leverage the full potential of connected vehicles, travelers and infrastructure to enhance current operational practices and tra...

  5. 40 CFR 63.746 - Standards: Depainting operations.

    Science.gov (United States)

    2010-07-01

    ... formulations and agents or chemical paint softeners. (2) Where non-chemical based equipment is used to comply... system is used, continuously monitor the water flow rate, and read and record the water flow rate once... stringent, shut down the operation immediately and take corrective action. If the water path in the...

  6. Development and Application of Methods for Estimating Operating Characteristics of Discrete Test Item Responses without Assuming any Mathematical Form.

    Science.gov (United States)

    Samejima, Fumiko

    In latent trait theory the latent space, or space of the hypothetical construct, is usually represented by some unidimensional or multi-dimensional continuum of real numbers. Like the latent space, the item response can either be treated as a discrete variable or as a continuous variable. Latent trait theory relates the item response to the latent…

  7. Response to the Petition to Object to the TVA Paradise Fossil Plant, Drakesboro, Kentucky, Title V Operating Permit

    Science.gov (United States)

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  8. Influence of oil-squeeze-film damping on steady-state response of flexible rotor operating to supercritical speeds

    Science.gov (United States)

    Cunningham, R. E.

    1977-01-01

    Experimental data were obtained for the unbalance response of a flexible rotor to speeds above the third lateral bending critical. Squeeze-film damping coefficients calculated from measured data showed good agreement with short-journal-bearing approximations over a frequency range from 5000 to 31,000 cmp. Response of a rotor to varying amounts of unbalance was investigated. A very lightly damped rotor was compared with one where oil-squeeze dampers were applied.

  9. Response probability and latency: a straight line, an operational definition of meaning and the structure of short term memory

    OpenAIRE

    Tarnow, Dr. Eugen

    2008-01-01

    The functional relationship between response probability and time is investigated in data from Rubin, Hinton and Wenzel (1999) and Anderson (1981). Recall/recognition probabilities and search times are linearly related through stimulus presentation lags from 6 seconds to 600 seconds in the former experiment and for repeated learning of words in the latter. The slope of the response time vs. probability function is related to the meaningfulness of the items used. The Rubin et al data sugges...

  10. Legal aspects of electric power supply. Grid operator obligations between entrepreneurial responsibility and state control; Das Recht der Elektrizitaetsversorgungsnetze. Netzbetreiberpflichten zwischen unternehmerischer Eigenverantwortung und staatlicher Steuerung

    Energy Technology Data Exchange (ETDEWEB)

    Maetzig, Karoline

    2012-07-01

    The publication provides a systematic outline of the legal boundary conditions governing the operation of electric power supply grids. It goes beyond mere regulatory aspects, covering also the projecting and construction of grids, the acquisition or leasing of land for power transmission line construction, operating licenses and utility certification, the organisational structure and purpose of electric utilities, as well as the operating, servicing and enhancement of electricity grids including calculation of electricity rates. In addition to this systematic outline of legal aspects, it is investigated how the balance between entrepreneurial responsibility and state control was defined in the EnWG 2011, and it is discussed if the law provides sufficient room for entrepreneurial decisions.

  11. 34 CFR 200.85 - Responsibilities of SEAs and operating agencies for improving services to migratory children.

    Science.gov (United States)

    2010-07-01

    ... improve the services provided to migratory children. (Authority: 20 U.S.C. 6394) ... improving services to migratory children. 200.85 Section 200.85 Education Regulations of the Offices of the... of SEAs and operating agencies for improving services to migratory children. While the specific...

  12. Reproductive behaviour of female rosy bitterling Rhodeus ocellatus in response to a female-biased operational sex ratio

    Czech Academy of Sciences Publication Activity Database

    Liao, C.; Yu, D.; Chen, Y.; Reichard, Martin; Liu, H.

    2014-01-01

    Roč. 151, č. 6 (2014), s. 755-768 ISSN 0005-7959 R&D Projects: GA ČR GBP505/12/G112 Institutional support: RVO:68081766 Keywords : alternative reproductive behaviour * female aggression * operational sex ratio * bitterling Subject RIV: EG - Zoology Impact factor: 1.230, year: 2014

  13. Evaluation of the Physiological Challenges in Extreme Environments: Implications for Enhanced Training, Operational Performance and Sex-Specific Responses

    Science.gov (United States)

    2017-10-01

    Evaluation of the physiological challenges in extreme environments: Implications for enhanced training, operational performance and sex-specific... evaluated . Furthermore, actual performance based measures must be evaluated after a period of training/acclimation. The aim of this project is...AWARD NUMBER: W81XWH-15-2-0075 TITLE: Evaluation of the Physiological Challenges in Extreme Environments: Implications for Enhanced Training

  14. Risk-Based Two-Stage Stochastic Optimization Problem of Micro-Grid Operation with Renewables and Incentive-Based Demand Response Programs

    Directory of Open Access Journals (Sweden)

    Pouria Sheikhahmadi

    2018-03-01

    Full Text Available The operation problem of a micro-grid (MG in grid-connected mode is an optimization one in which the main objective of the MG operator (MGO is to minimize the operation cost with optimal scheduling of resources and optimal trading energy with the main grid. The MGO can use incentive-based demand response programs (DRPs to pay an incentive to the consumers to change their demands in the peak hours. Moreover, the MGO forecasts the output power of renewable energy resources (RERs and models their uncertainties in its problem. In this paper, the operation problem of an MGO is modeled as a risk-based two-stage stochastic optimization problem. To model the uncertainties of RERs, two-stage stochastic programming is considered and conditional value at risk (CVaR index is used to manage the MGO’s risk-level. Moreover, the non-linear economic models of incentive-based DRPs are used by the MGO to change the peak load. The numerical studies are done to investigate the effect of incentive-based DRPs on the operation problem of the MGO. Moreover, to show the effect of the risk-averse parameter on MGO decisions, a sensitivity analysis is carried out.

  15. RESPONSIBILITIES OF FOOD BUSINESS OPERATORS RELATED TO FOOD SAFETY: CONCERNS RELATED TO HACCP IN MICRO-BUSINESSES FOOD COMPANIES

    Directory of Open Access Journals (Sweden)

    T. Civera

    2012-08-01

    Full Text Available The research was aimed at collecting information on food safety knowledge by operators of small and less developed food businesses. This will allow to reveal what are the real drawbacks in HACCP application in these realities. Fifty meat producing plants located in Piedmont region were involved. In all the plants a questionnaire with questions on HACCP system was submitted. The analysis of the collected answers, evidenced that 42% of the operators needed to perform structural modifications in order to address the HACCP measures, whereas 40% applied modifications in working procedures. The most frequent shortcoming (44% of the answers of the HACCP system was represented by the applicability of Good Manufacturing Practices, and the most difficult control measure to be applied was the prevention of the cross-contaminations (40% of the answers. The information gathered within this project allowed to evidence the real needs of the micro businesses in the application of HACCP plan. These results can be useful for the institutions, which could elaborate HACCP alternative systems, able to better fulfil food safety requirements and Food Business Operator needs.

  16. Ventilator-induced central venous pressure variation can predict fluid responsiveness in post-operative cardiac surgery patients

    NARCIS (Netherlands)

    Cherpanath, T. G. V.; Geerts, B. F.; Maas, J. J.; de Wilde, R. B. P.; Groeneveld, A. B.; Jansen, J. R.

    2016-01-01

    Ventilator-induced dynamic hemodynamic parameters such as stroke volume variation (SVV) and pulse pressure variation (PPV) have been shown to predict fluid responsiveness in contrast to static hemodynamic parameters such as central venous pressure (CVP). We hypothesized that the ventilator-induced

  17. Increasing the Number of Replications in Item Response Theory Simulations: Automation through SAS and Disk Operating System

    Science.gov (United States)

    Gagne, Phill; Furlow, Carolyn; Ross, Terris

    2009-01-01

    In item response theory (IRT) simulation research, it is often necessary to use one software package for data generation and a second software package to conduct the IRT analysis. Because this can substantially slow down the simulation process, it is sometimes offered as a justification for using very few replications. This article provides…

  18. Response

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Neuromorphic silicon chips have been developed over the last 30 years, inspired by the design of biological nervous systems and offering an alternative paradigm for computation, with real-time massively parallel operation and potentially large power savings with respect to conventional computing architectures. I will present the general principles with a brief investigation of the design choices that have been explored, and I'll discuss how such hardware has been applied to problems such as classification.

  19. From Data to Knowledge — Faster: GOES Early Fire Detection System to Inform Operational Wildfire Response and Management

    Science.gov (United States)

    Koltunov, A.; Quayle, B.; Prins, E. M.; Ambrosia, V. G.; Ustin, S.

    2014-12-01

    Fire managers at various levels require near-real-time, low-cost, systematic, and reliable early detection capabilities with minimal latency to effectively respond to wildfire ignitions and minimize the risk of catastrophic development. The GOES satellite images collected for vast territories at high temporal frequencies provide a consistent and reliable source for operational active fire mapping realized by the WF-ABBA algorithm. However, their potential to provide early warning or rapid confirmation of initial fire ignition reports from conventional sources remains underutilized, partly because the operational wildfire detection has been successfully optimized for users and applications for which timeliness of initial detection is a low priority, contrasting to the needs of first responders. We present our progress in developing the GOES Early Fire Detection (GOES-EFD) system, a collaborative effort led by University of California-Davis and USDA Forest Service. The GOES-EFD specifically focuses on first detection timeliness for wildfire incidents. It is automatically trained for a monitored scene and capitalizes on multiyear cross-disciplinary algorithm research. Initial retrospective tests in Western US demonstrate significantly earlier identification detection of new ignitions than existing operational capabilities and a further improvement prospect. The GOES-EFD-β prototype will be initially deployed for the Western US region to process imagery from GOES-NOP and the rapid and 4 times higher spatial resolution imagery from GOES-R — the upcoming next generation of GOES satellites. These and other enhanced capabilities of GOES-R are expected to significantly improve the timeliness of fire ignition information from GOES-EFD.

  20. Behavioral Responses Of Fish To A Current-Based Hydrokinetic Turbine Under Mutlipe Operational Conditions: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Grippo, Mark A. [Argonne National Lab. (ANL), Argonne, IL (United States); Shen, Haixue [Univ. of Maine, Orono, ME (United States); Zydlewski, Gayle [Univ. of Maine, Orono, ME (United States); Rao, Shivanesh [Univ. of Maine, Orono, ME (United States); Goodwin, Andy [United States Army Engineer R & D Center, Vicksburg, MI (United States)

    2017-02-01

    There is significant interest in the interaction of aquatic organisms with current-based marine and hydrokinetic (MHK) technologies. Determining the potential impacts of MHK devices on fish behavior is critical to addressing the environmental concerns that could act as barriers to the permitting and deployment of MHK devices. To address these concerns, we use field monitoring and fish behavior models to characterize the behavioral responses of fish to MHK turbines and infer potential stimuli that may have elicited the observed behavioral changes.

  1. Operating Systems

    Indian Academy of Sciences (India)

    The process concept and concurrency are at the heart of modern operating systems (OS). A process is the unit of work in a computer system. A process must be in main memory during execution. To improve the utilization of central processing unit. (CPU) as well as the speed of its response to its users, the computer must ...

  2. Impact of energy devices on the post-operative systemic immune response in women undergoing total laparoscopic hysterectomy for benign disease of the uterus

    Science.gov (United States)

    Roy, Kallol Kumar; GC, Netra; Singhal, Seema; Bharti, Juhi; Kumar, Sunesh; Mitra, Dipendra K.; Ray, Ruma; Meena, Jyoti; Vanamail, Perumal

    2018-01-01

    Objective: Laparoscopic surgery is associated with reduced surgical stress response, lesser post- operative immune function, and consequent early recovery compared with conventional open surgery. There is a lack of evidence regarding the inflammatory stress response with the use of different energy devices. The present study was conducted to evaluate and compare the inflammatory response in total laparoscopic hysterectomy (TLH) using three different energy devices. Material and Methods: A prospective randomized controlled study was conducted in 60 women with abnormal uterine bleeding undergoing TLH. They were divided into three groups based on the energy devices used, namely integrated bipolar and ultrasonic energy (Thunderbeat), ultrasonic (Harmonic) and electrothermal bipolar vessel sealing system (Ligasure). Cytokines and chemokines were measured in all three groups at different time points. Results: Serum levels of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) increased postsurgery in all three groups and gradually declined by 72 hours. The geometric mean serum (IL)-6 levels was highest with Ligasure at 24 hours as compared with the other groups. Levels of TNF-α, macrophage inflammatory protein (MIP-1) α, MIP-1 β were also higher at 3 hours in the Ligasure group. When the differences between the groups were measured at different time points, there was a significantly greater increase in serum IL-6 levels in the Ligasure group at 24 hours (p=0.010). No significant difference was found in the post-operative course between the groups. Conclusion: A greater inflammatory response was seen after the use of Ligasure indicating greater tissue damage. However, this response was not correlated with any difference in postoperative recovery. PMID:29503255

  3. The Epidemiology of Operation Stress during Continuing Promise 2011: A Humanitarian Response and Disaster Relief Mission aboard a US Navy Hospital Ship.

    Science.gov (United States)

    Scouten, William T; Mehalick, Melissa L; Yoder, Elizabeth; McCoy, Andrea; Brannock, Tracy; Riddle, Mark S

    2017-08-01

    Introduction Operational stress describes individual behavior in response to the occupational demands and tempo of a mission. The stress response of military personnel involved in combat and peace-keeping missions has been well-described. The spectrum of effect on medical professionals and support staff providing humanitarian assistance, however, is less well delineated. Research to date concentrates mainly on shore-based humanitarian missions. Problem The goal of the current study was to document the pattern of operational stress, describe factors responsible for it, and the extent to which these factors impact job performance in military and civilian participants of Continuing Promise 2011 (CP11), a ship-based humanitarian medical mission. This was a retrospective study of Disease Non-Battle Injury (DNBI) data from the medical sick-call clinic and from weekly self-report questionnaires for approximately 900 US military and civilian mission participants aboard the USNS COMFORT (T-AH 20). The incidence rates and job performance impact of reported Operational Stress/Mental Health (OS/MH) issues and predictors (age, rank, occupation, service branch) of OS/MH issues (depression, anxiety) were analyzed over a 22-week deployment period. Incidence rates of OS/MH complaints from the sick-call clinic were 3.7% (4.5/1,000 persons) and 12.0% (53/1,000 persons) from the self-report questionnaire. The rate of operational stress increased as the mission progressed and fluctuated during the mission according to ship movement. Approximately 57% of the responders reported no impact on job performance. Younger individuals (enlisted ranks E4-6, officer ranks O1-3), especially Air Force service members, those who had spent only one day off ship, and those who were members of specific directorates, reported the highest rates of operational stress. The overall incidence of OS/MH complaints was low in participants of CP11 but was under-estimated by clinic-based reporting. The OS

  4. Seismic and dynamic qualification of safety-related electrical and mechanical equipment in operating nuclear power plants: development of a method to generate generic floor-response spectra

    International Nuclear Information System (INIS)

    Curreri, J.; Costantino, C.; Subudhi, M.; Reich, M.

    1983-09-01

    Generic floor response spectra were developed for use in the qualification of electrical and mechanical equipment in operating nuclear power plants. The characteristics of 1000 floor response spectra were studied to determine the generic spectra. The procedure developed uses as much or as little information that currently exists at the plant relating to the question of equipment qualification. The general approach was to study the effects on the dynamic characteristics of each of the elements in the chain of events that goes between the loads and the responses. This includes the loads, the soils and the structures. A free-field earthquake response spectra was used to generate horizontal earthquake time histories. The excitation was applied through the soil and into the various structures to produce responses in equipment. An entire range of soil conditions was used with each structure. Actual PWR and BWR - Mark I structural models were used. For each model, the stiffness properties were varied, with the same mass, so as to extend the fundamental base structure natural frequency from 2 cps to 36 cps. The natural frequencies of the structures were varied to obtain maximum response conditions. The actual properties were first used to locate the natural frequencies. The stiffness properties were than varied, with the same mass, to extend the range of the fundamental base structure natural frequency. The intention was to have the coupled structural material frequencies in the vicinity of the peak amplitude frequency content of the excitation spectrum. Particular attention was therefore given to the frequency band between 2 Hz and 4 Hz. A horizontal generic floor response spectra is proposed for the top level of a generic structure. Reduction factors are applied to the peak acceleration for equipment at lower levels

  5. Adaptive Capacity and Social-Environmental Change: Theoretical and Operational Modeling of Smallholder Coffee Systems Response in Mesoamerican Pacific Rim

    Science.gov (United States)

    Eakin, Hallie; Bojórquez-Tapia, Luis A.; Diaz, Rafael Monterde; Castellanos, Edwin; Haggar, Jeremy

    2011-03-01

    Communities who rely directly on the natural environment for their survival typically have developed risk management strategies to enable them to avoid dangerous thresholds of change to their livelihoods. Development policy appropriate for natural resource-based communities requires an understanding of the primary drivers of social-ecological change, the ways in which affected households autonomously respond to such drivers, and the appropriate avenues for intervention to reduce vulnerability. Coffee has been, and still remains, one of the most important commodities of the Mesoamerican region, and hundreds of thousands of smallholder households in the region are dependent in some way on the coffee industry for their livelihood stability. We used the Analytical Network Process to synthesize expert knowledge on the primary drivers of livelihood change in the region as well as the most common household strategies and associated capacities necessary for effective response. The assessment identified both gradual systemic processes as well as specific environmental and market shocks as significant drivers of livelihood change across the region. Agronomic adjustments and new forms of social organization were among the more significant responses of farmers to these changes. The assessment indicates that public interventions in support of adaptation should focus on enhancing farmers' access to market and technical information and finance, as well as on increasing the viability of farmers' organizations and cooperatives.

  6. Cyber Safety and Security for Reduced Crew Operations (RCO)

    Science.gov (United States)

    Driscoll, Kevin

    2017-01-01

    NASA and the Aviation Industry is looking into reduced crew operations (RCO) that would cut today's required two-person flight crews down to a single pilot with support from ground-based crews. Shared responsibility across air and ground personnel will require highly reliable and secure data communication and supporting automation, which will be safety-critical for passenger and cargo aircraft. This paper looks at the different types and degrees of authority delegation given from the air to the ground and the ramifications of each, including the safety and security hazards introduced, the mitigation mechanisms for these hazards, and other demands on an RCO system architecture which would be highly invasive into (almost) all safety-critical avionics. The adjacent fields of unmanned aerial systems and autonomous ground vehicles are viewed to find problems that RCO may face and related aviation accident scenarios are described. The paper explores possible data communication architectures to meet stringent performance and information security (INFOSEC) requirements of RCO. Subsequently, potential challenges for RCO data communication authentication, encryption and non-repudiation are identified. The approach includes a comprehensive safety-hazard analysis of the RCO system to determine top level INFOSEC requirements for RCO and proposes an option for effective RCO implementation. This paper concludes with questioning the economic viability of RCO in light of the expense of overcoming the operational safety and security hazards it would introduce.

  7. Federal Environmental Regulations Impacting Hydrocarbon Exploration, Drilling, and Production Operations

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, Herbert B.; Johnson, William I.

    1999-04-27

    Waste handling and disposal from hydrocarbon exploration, drilling, and production are regulated by the US Environmental Protection Agency (EPA) through federal and state regulations and/or through implementation of federal regulations. Some wastes generated in these operations are exempt under the Resource Conservation and Recovery Act (RCRA) but are not exempt under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), Superfund Amendments and Reauthorization Act (SARA), and other federal environmental laws. Exempt wastes remain exempt only if they are not mixed with hazardous wastes or hazardous substances. Once mixture occurs, the waste must be disposed as a hazardous material in an approved hazardous waste disposal facility. Before the Clean Air Act as amended in 1990, air emissions from production, storage, steam generation, and compression facilities associated with hydrocarbon exploration, drilling, and production industry were not regulated. A critical proposed regulatory change which will significantly effect Class II injection wells for disposal of produced brine and injection for enhanced oil recovery is imminent. Federal regulations affecting hydrocarbon exploration, drilling and production, proposed EPA regulatory changes, and a recent significant US Court of Appeals decision are covered in this report. It appears that this industry will, in the future, fall under more stringent environmental regulations leading to increased costs for operators.

  8. Gulf of Mexico offshore operations monitoring experiment (GOOMEX), Phase I: Sublethal responses to contaminant exposure - introduction and overview

    International Nuclear Information System (INIS)

    Kennicutt, M. C.; Montagna, P.; Roscigno, P. F.

    1996-01-01

    An overview of a three-phase study to evaluate the range of biological, biochemical and chemical methodologies to detect and assess chronic sublethal biological impacts in the vicinity of long-duration activities in the Gulf of Mexico associated with oil and gas exploration and production, was provided. The basic program comprises four activities stretching over a two-year period, and is designed to detect nearfield impacts and contaminant gradients extending out of each of three sites. Sampling design includes a radial pattern with stations at intervals up to 3000 meters distant from the platform. The design employs a dose-response model to test the hypothesis that biological, biochemical and chemical variations are due to platform-derived contaminants. Detailed analysis of the contaminants includes analysis of sediments, pore waters and biological tissue, and assessment of community health based on life history and reproduction studies. 57 refs., 9 tabs., 5 figs

  9. Making operations on standard-library containers strongly exception safe

    DEFF Research Database (Denmark)

    Katajainen, Jyrki

    2007-01-01

    An operation on an element container is said to provide a strong guarantee of exception safety if, in case an exception is thrown, the operation leaves the container in the state in which it was before the operation. In this paper, we explore how to adjust operations on C++ standard......-library containers to provide the strong guarantee of exception safety, instead of the default guarantee, without violating the stringent performance requirements specified in the C++ standard. In particular, we show that every strongly exception-safe operation on dynamic arrays and ordered dictionaries is only...

  10. Final Environmental Impact Statement for the construction and operation of Claiborne Enrichment Center, Homer, Louisiana (Docket No. 70-3-70). Volume 2, Public comments and NRC response

    Energy Technology Data Exchange (ETDEWEB)

    Zeitoun, A. [Science Applications International Corp., Germantown, MD (United States)

    1994-08-01

    The Final Environmental Impact Statement (FEIS) (Volume 1), was prepared by the Nuclear Regulatory Commission (NRC) in accordance with regulation 10 CFR Part 51, which implements the National Environmental Policy Act (NEPA), to assess the potential environmental impacts for licensing the construction and operation of a proposed gaseous centrifuge enrichment facility to be built in Claiborne Parish, Louisiana by Louisiana Energy Services, L.P. (LES). The proposed facility would have a production capacity of about 866 metric tons annually of up to 5 weight percent enriched UF{sub 6}, using a proven centrifuge technology. Included in the assessment are co on, both normal operations and potential accidents (internal and external events), and the eventual decontamination and decommissioning of the site. In order to help assure that releases from the operation of the facility and potential impacts on the public are as low as reasonably achievable, an environmental monitoring program was developed by LES to detect significant changes in the background levels of uranium around the site. Other issues addressed include the purpose and need for the facility, the alternatives to the proposed action, potential disposition of the tails, the site selection process, and environmental justice. The NRC staff concludes that the facility can be constructed and operated with small and acceptable impacts on the public and the environment, and proposes to issue a license to the applicant, Louisiana Energy Services, to authorize construction and operation of the proposed facility. The letters in this Appendix have been divided into three sections. Section One contains letters to which the NRC responded by addressing specific comments. Section Two contains the letters that concerned the communities of Forest Grove and Center Springs. Section Three is composed of letters that required no response. These letters were generally in support of the facility.

  11. Final Environmental Impact Statement for the construction and operation of Claiborne Enrichment Center, Homer, Louisiana (Docket No. 70-3-70). Volume 2, Public comments and NRC response

    International Nuclear Information System (INIS)

    Zeitoun, A.

    1994-08-01

    The Final Environmental Impact Statement (FEIS) (Volume 1), was prepared by the Nuclear Regulatory Commission (NRC) in accordance with regulation 10 CFR Part 51, which implements the National Environmental Policy Act (NEPA), to assess the potential environmental impacts for licensing the construction and operation of a proposed gaseous centrifuge enrichment facility to be built in Claiborne Parish, Louisiana by Louisiana Energy Services, L.P. (LES). The proposed facility would have a production capacity of about 866 metric tons annually of up to 5 weight percent enriched UF 6 , using a proven centrifuge technology. Included in the assessment are co on, both normal operations and potential accidents (internal and external events), and the eventual decontamination and decommissioning of the site. In order to help assure that releases from the operation of the facility and potential impacts on the public are as low as reasonably achievable, an environmental monitoring program was developed by LES to detect significant changes in the background levels of uranium around the site. Other issues addressed include the purpose and need for the facility, the alternatives to the proposed action, potential disposition of the tails, the site selection process, and environmental justice. The NRC staff concludes that the facility can be constructed and operated with small and acceptable impacts on the public and the environment, and proposes to issue a license to the applicant, Louisiana Energy Services, to authorize construction and operation of the proposed facility. The letters in this Appendix have been divided into three sections. Section One contains letters to which the NRC responded by addressing specific comments. Section Two contains the letters that concerned the communities of Forest Grove and Center Springs. Section Three is composed of letters that required no response. These letters were generally in support of the facility

  12. Serum Vitamin D Levels Affect Pathologic Complete Response in Patients Undergoing Neoadjuvant Systemic Therapy for Operable Breast Cancer.

    Science.gov (United States)

    Chiba, Akiko; Raman, Rachna; Thomas, Alexandra; Lamy, Pierre-Jean; Viala, Marie; Pouderoux, Stephane; Mott, Sarah L; Schroeder, Mary C; Thezenas, Simon; Jacot, William

    2017-12-11

    There has been increasing interest in the potential benefit of vitamin D in improving breast cancer outcome. Preclinical studies suggest that vitamin D enhances chemotherapy-induced cell death. We investigated the impact of serum vitamin D levels during neoadjuvant chemotherapy (NAC) on the rates of achieving pathologic complete response (pCR) after breast cancer NAC. Patients from 1 of 2 Iowa registries who had serum vitamin D level measured before or during NAC were included. French patients enrolled onto a previous study of the impact of NAC on vitamin D and bone metabolism were also eligible for this study. Vitamin D deficiency was defined as P = .20), clinical stage (P = .22), receptor status (P = .32), and pCR rate (P = .34). French women had lower body mass index (mean 24.8 vs. 28.8, P D levels (mean 21.5 vs. 27.5, P D deficiency increased the odds of not attaining pCR by 2.68 times (95% confidence interval, 1.12-6.41, P = .03). Low serum vitamin D levels were associated with not attaining a pCR. Prospective trials could elucidate if maintaining vitamin D levels during NAC, a highly modifiable variable, may be utilized to improve cancer outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Effect of radiation on the response of dental pulp to operative and endodontic procedures: an experimental study

    Energy Technology Data Exchange (ETDEWEB)

    Fawzi, M.I.; Shklar, G.; Krakow, A.A.

    1985-04-01

    Thirty-six 56-day-old male Sprague-Dawley albino rats served as two groups of experimental animals. Group 1 was irradiated with 400 rads delivered as total-body radiation from a cesium source. Group 2 served as the control group and was not irradiated. Three weeks later, the dental microscope was used to facilitate various dental procedures in both groups of animals (cavity preparation filled with zinc oxide-eugenol, pulp exposure capped with zinc oxide-eugenol, and pulp exposure left open). Two animals for each procedure from Groups 1 and 2 were killed at time intervals of 2, 4, and 8 weeks. The results showed that (1) radiation at this dose resulted in a depression of the normal response of the dental pulp to the trauma and infection induced by pulpal exposure, (2) there were no pathologic changes in the untreated molars of the irradiated animals, and (3) the use of the dental microscope greatly facilitated cavity preparation in the molars of rats.

  14. Cognitive modeling and dynamic probabilistic simulation of operating crew response to complex system accidents. Part 2: IDAC performance influencing factors model

    International Nuclear Information System (INIS)

    Chang, Y.H.J.; Mosleh, A.

    2007-01-01

    This is the second in a series of five papers describing the information, decision, and action in crew context (IDAC) model for human reliability analysis. An example application of this modeling technique is also discussed in this series. The model is developed to probabilistically predict the responses of the nuclear power plant control room operating crew in accident conditions. The operator response spectrum includes cognitive, psychological, and physical activities during the course of an accident. This paper identifies the IDAC set of performance influencing factors (PIFs), providing their definitions and causal organization in the form of a modular influence diagram. Fifty PIFs are identified to support the IDAC model to be implemented in a computer simulation environment. They are classified into eleven hierarchically structured groups. The PIFs within each group are independent to each other; however, dependencies may exist between PIFs within different groups. The supporting evidence for the selection and organization of the influence paths based on psychological literature, observations, and various human reliability analysis methodologies is also indicated

  15. A Multi-Response Optimization of Thrust Forces, Torques, and the Power of Tapping Operations by Cooling Air in Reinforced and Unreinforced Polyamide PA66

    Directory of Open Access Journals (Sweden)

    Rosario Domingo

    2018-03-01

    Full Text Available The use of cooling air during machining is an environmentally conscious procedure, and its applicability to different processes is a research priority. We studied tapping operations, an important operation in the assembly process, using cooling air with unreinforced polyamide (PA66 and polyamide reinforced with glass fiber (PA66-GF30. These materials are widely used in industry, but their behavior with respect to tapping has not been studied. We analyze the outcomes regarding the thrust force, torque, and power at cutting speeds between 15 and 60 m/min. The experimental tests were executed using cooling air at 22 °C, 2 °C, and −18 °C in dry conditions. The M12 × 1.75 mm taps were high-speed steel, with cobalt as the base material and coatings of TiN and AlCrN. To identify the more influential factors, an analysis of variance was performed, along with multi-response optimization to identify the desirability values. This optimization shows that the optimum for PA66can be found in environments close to 3 °C, while the optimum for PA66-GF30 is found at the minimal temperature studied (−18 °C. Thus, cooling air can be considered an adequate procedure for tapping operations, to increase the sustainability of the manufacturing processes.

  16. An artificial intelligence system for assisting nuclear power plant operators in the diagnosis of and response to plant faults and transients

    International Nuclear Information System (INIS)

    Hajek, B.K.; Stasenko, J.E.; Bhatnagar, R.; Hashemi, S.

    1987-12-01

    This report discusses the Artificial Intelligence (AI) system being developed using the Conceptual Structures and Representation Language (CSRL) developed at the Ohio State University Laboratory for Artificial Intelligence Research (LAIR). This system combines three sub-systems which have been independently developed to perform the tasks of: detecting changes in the state of the plant that may lead to conditions requiring operator response, and then managing the actions taken by the other two subsystems; diagnosing the plant status independent of alarm states by analyzing the status of basic operating parameters such as flow rates, pressures, temperatures, and water levels, and providing a determination of the validity of sensor indications; and providing and/or synthesizing an appropriate procedure for the operator to follow to correct the transient or abnormal state of the plant. These three systems are tied into the main plant computers, including both the process computer and the safety parameter and display system computer, through the use of a compatible database. The architecture of the system is shown in Figure 1. The system is being developed using the Perry Nuclear Power Plant (a BWR/6) as the reference plant, and the General Electric ERIS and GEPAC Plus systems as key data sources. Scenarios are run on the Perry plant referenced simulator for testing of the AI system. Future testing plans call for the system to be interfaced directly to the Perry simulator

  17. Prenatal Association between a Chemosensory Cue (Cineole and Ethanol Postabsortive Effects Modulates Later Operant Responsiveness to Cineole-Flavored Milk in 1 Day Old Rats

    Directory of Open Access Journals (Sweden)

    March, Samanta Mabel

    2011-07-01

    Full Text Available Near-term rat fetuses detect and associate ethanol’s sensory and postabsortive properties. We aimed to evaluate changes upon operant conditioning in neonates, as a function of prenatal ethanol-mediated associative experiences. Prenatal treatments were: Paired group, dams administered (i.g. with cineole and 15-min later with EtOH (2.0 g/kg; Long-delay group, dams received cineole 6 hours before ethanol intoxication; Water group, dams received two administrations of water separated by 15 min. On PD1 neonates were trained in an operant task. Two different learning conditions were used. Paired pups were trained under a FR=1 reinforcement schedule. Yoked pups received the reinforcer but, unrelated to their own behavior. Milk or Cineole-flavored milk were the reinforce solutions. Present results support the idea that ethanol-related prenatal memories modulate operant responsiveness when pups are re-exposed to cues that predict toxic consequences of the drug.

  18. An artificial intelligence system for assisting nuclear power plant operators in the diagnosis of the response to plant faults and transients

    International Nuclear Information System (INIS)

    Hajek, B.K.

    1987-01-01

    An artificial intelligence system is being developed using the Conceptual Structures and Representation Language (CSRL) developed at The Ohio State University Laboratory for Artificial Intelligence Research (LAIR). This system combines three subsystems, which have been independently developed to perform the following tasks: (1) detecting changes in the state of the plant that may lead to conditions requiring operator response and then managing the actions taken by the other two subsystems, (2) diagnosing the plant status independent of alarm states by analyzing the status of basic operating parameters, such as flow rates, pressures, temperatures, and water levels, and providing a determination of the validity of sensor indications, and (3) providing and/or synthesizing an appropriate procedure for the operator to follow to correct the transient of abnormal state of the plant. These three system are tied into the main plant computers, including both the process computer and the safety parameter and display system computer, through the use of a compatible data base. The system is being developed using the Perry Nuclear Power Plant (a BWR/6) as the reference plant, and the General Electric ERIS and GEPAC Plus systems as key data sources. Scenarios are run on by the Perry plant referenced simulator for testing of the artificial intelligence system. Future testing plans call for the system to be interfaced directly to the Perry simulator

  19. Response of Bighead Carp and Silver Carp to repeated water gun operation in an enclosed shallow pond

    Science.gov (United States)

    Romine, Jason G.; Jensen, Nathan; Parsley, Michael J.; Gaugush, Robert F.; Severson, Todd J.; Hatton, Tyson W.; Adams, Ryan F.; Gaikowski, Mark P.

    2015-01-01

    The Bighead Carp Hypophthalmichthys nobilis and Silver Carp H. molitrix are nonnative species that pose a threat to Great Lakes ecosystems should they advance into those areas. Thus, technologies to impede Asian carp movement into the Great Lakes are needed; one potential technology is the seismic water gun. We evaluated the efficacy of a water gun array as a behavioral deterrent to the movement of acoustic-tagged Bighead Carp and Silver Carp in an experimental pond. Behavioral responses were evaluated by using four metrics: (1) fish distance from the water guns (D); (2) spatial area of the fish's utilization distribution (UD); (3) persistence velocity (Vp); and (4) number of times a fish transited the water gun array. For both species, average D increased by 10 m during the firing period relative to the pre-firing period. During the firing period, the spatial area of use within the pond decreased. Carp were located throughout the pond during the pre-firing period but were concentrated in the north end of the pond during the firing period, thus reducing their UDs by roughly 50%. Overall, Vp decreased during the firing period relative to the pre-firing period, as fish movement became more tortuous and confined, suggesting that the firing of the guns elicited a change in carp behavior. The water gun array was partially successful at impeding carp movement, but some fish did transit the array. Bighead Carp moved past the guns a total of 78 times during the pre-firing period and 15 times during the firing period; Silver Carp moved past the guns 96 times during the pre-firing period and 13 times during the firing period. Although the water guns did alter carp behavior, causing the fish to move away from the guns, this method was not 100% effective as a passage deterrent.

  20. Space station operations management

    Science.gov (United States)

    Cannon, Kathleen V.

    1989-01-01

    Space Station Freedom operations management concepts must be responsive to the unique challenges presented by the permanently manned international laboratory. Space Station Freedom will be assembled over a three year period where the operational environment will change as significant capability plateaus are reached. First Element Launch, Man-Tended Capability, and Permanent Manned Capability, represent milestones in operational capability that is increasing toward mature operations capability. Operations management concepts are being developed to accomodate the varying operational capabilities during assembly, as well as the mature operational environment. This paper describes operations management concepts designed to accomodate the uniqueness of Space Station Freedoom, utilizing tools and processes that seek to control operations costs.

  1. Numerical Study of the Dynamic Response of Heat and Mass Transfer to Operation Mode Switching of a Unitized Regenerative Fuel Cell

    Directory of Open Access Journals (Sweden)

    Hong Xiao

    2016-12-01

    Full Text Available Knowledge concerning the complicated changes of mass and heat transfer is desired to improve the performance and durability of unitized regenerative fuel cells (URFCs. In this study, a transient, non-isothermal, single-phase, and multi-physics mathematical model for a URFC based on the proton exchange membrane is generated to investigate transient responses in the process of operation mode switching from fuel cell (FC to electrolysis cell (EC. Various heat generation mechanisms, including Joule heat, reaction heat, and the heat attributed to activation polarizations, have been considered in the transient model coupled with electrochemical reaction and mass transfer in porous electrodes. The polarization curves of the steady-state models are validated by experimental data in the literatures. Numerical results reveal that current density, gas mass fractions, and temperature suddenly change with the sudden change of operating voltage in the mode switching process. The response time of temperature is longer than that of current density and gas mass fractions. In both FC and EC modes, the cell temperature and gradient of gas mass fraction in the oxygen side are larger than that in the hydrogen side. The temperature difference of the entire cell is less than 1.5 K. The highest temperature appears at oxygen-side catalyst layer under the FC mode and at membrane under a more stable EC mode. The cell is exothermic all the time. These dynamic responses and phenomena have important implications for heat analysis and provide proven guidelines for the improvement of URFCs mode switching.

  2. Multi-Objective Optimization of Moving-magnet Linear Oscillatory Motor Using Response Surface Methodology with Quantum-Behaved PSO Operator

    Science.gov (United States)

    Lei, Meizhen; Wang, Liqiang

    2018-01-01

    To reduce the difficulty of manufacturing and increase the magnetic thrust density, a moving-magnet linear oscillatory motor (MMLOM) without inner-stators was Proposed. To get the optimal design of maximum electromagnetic thrust with minimal permanent magnetic material, firstly, the 3D finite element analysis (FEA) model of the MMLOM was built and verified by comparison with prototype experiment result. Then the influence of design parameters of permanent magnet (PM) on the electromagnetic thrust was systematically analyzed by the 3D FEA to get the design parameters. Secondly, response surface methodology (RSM) was employed to build the response surface model of the new MMLOM, which can obtain an analytical model of the PM volume and thrust. Then a multi-objective optimization methods for design parameters of PM, using response surface methodology (RSM) with a quantum-behaved PSO (QPSO) operator, was proposed. Then the way to choose the best design parameters of PM among the multi-objective optimization solution sets was proposed. Then the 3D FEA of the optimal design candidates was compared. The comparison results showed that the proposed method can obtain the best combination of the geometric parameters of reducing the PM volume and increasing the thrust.

  3. The central dynamics of M3, M13, and M92: stringent limits on the masses of intermediate-mass black holes

    Science.gov (United States)

    Kamann, S.; Wisotzki, L.; Roth, M. M.; Gerssen, J.; Husser, T.-O.; Sandin, C.; Weilbacher, P.

    2014-06-01

    We used the PMAS integral field spectrograph to obtain large sets of radial velocities in the central regions of three northern Galactic globular clusters: M3, M13, and M92. By applying the novel technique of crowded field 3D spectroscopy, we measured radial velocities for about 80 stars within the central ~10″ of each cluster. These are by far the largest spectroscopic datasets obtained in the innermost parts of these clusters up to now. To obtain kinematical data across the whole extent of the clusters, we complement our data with measurements available in the literature. We combine our velocity measurements with surface brightness profiles to analyse the internal dynamics of each cluster using spherical Jeans models, and investigate whether our data provide evidence for an intermediate-mass black hole in any of the clusters. The surface brightness profiles reveal that all three clusters are consistent with a core profile, although shallow cusps cannot be excluded. We find that spherical Jeans models with a constant mass-to-light ratio provide a good overall representation of the kinematical data. A massive black hole is required in none of the three clusters to explain the observed kinematics. Our 1σ (3σ) upper limits are 5300 M⊙ (12 000 M⊙) for M3, 8600 M⊙ (13 000 M⊙) for M13, and 980 M⊙ (2700 M⊙) for M92. A puzzling circumstance is the existence of several potential high velocity stars in M3 and M13, as their presence can account for the majority of the discrepancies that we find in our mass limits compared to M92. Based on observations collected at the Centro Astronómico Hispano-Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).Appendices are available in electronic form at http://www.aanda.orgTables D.1 to D.6 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc

  4. Operating experience

    International Nuclear Information System (INIS)

    McRae, L.P.; Six, D.E.

    1991-01-01

    In 1987, Westinghouse Hanford Company began operating a first-generation integrated safeguards system in the Plutonium Finishing Plant storage vaults. This Vault Safety and Inventory System is designed to integrate data into a computer-based nuclear material inventory monitoring system. The system gathers, in real time, measured physical parameters that generate nuclear material inventory status data for thousands of stored items and sends tailored report to the appropriate users. These data include canister temperature an bulge data reported to Plant Operations and Material Control and Accountability personnel, item presence and identification data reported to Material Control and Accountability personnel, and unauthorized item movement data reported to Security response forces and Material Control and Accountability personnel. The Westinghouse Hanford Company's experience and operational benefits in using this system for reduce radiation exposure, increase protection against insider threat, and real-time inventory control are discussed in this paper

  5. Biobehavioral Insights into Adaptive Behavior in Complex and Dynamic Operational Settings: Lessons learned from the Soldier Performance and Effective, Adaptable Response Task

    Directory of Open Access Journals (Sweden)

    Amy J. Haufler

    2018-02-01

    Full Text Available The purpose of this study was to explore the biobehavioral correlates of adaptive behavior in the context of a standardized laboratory-based mission-relevant challenge [the Soldier Performance and Effective, Adaptable Response (SPEAR task]. Participants were 26 healthy male volunteers (M = 34.85 years, SD = 4.12 with active military duty and leadership experience within the last 5 years (i.e., multiple leadership positions, operational deployments in combat, interactions with civilians and partner nation forces on the battlefield, experience making decisions under fire. The SPEAR task simultaneously engages perception, cognition, and action aspects of human performance demands similar to those encountered in the operational setting. Participants must engage with military-relevant text, visual, and auditory stimuli, interpret new information, and retain the commander’s intent in working memory to create a new plan of action for mission success. Time-domain measures of heart period and respiratory sinus arrhythmia (RSA were quantified, and saliva was sampled [later assayed for cortisol and alpha-amylase (sAA] before-, during-, and post-SPEAR. Results revealed a predictable pattern of withdraw and recovery of the cardiac vagal tone during repeated presentation of battlefield challenges. Recovery of vagal inhibition following executive function challenge was strongly linked to better task-related performance. Rate of RSA recovery was also associated with better recall of the commander’s intent. Decreasing magnitude in the skin conductance response prior to the task was positively associated with better overall task-related performance. Lower levels of RSA were observed in participants who reported higher rates of combat deployments, and reduced RSA flexibility was associated with higher rates of casualty exposure. Greater RSA flexibility during SPEAR was associated with greater self-reported resilience. There was no consistent

  6. On the improvement of the response capability of the control room operator in a pressurized water reactor nuclear power plant in a severe earthquake through the use of emergency response guidelines

    International Nuclear Information System (INIS)

    Lee, S.

    1989-01-01

    Recent probabilistic risk assessment studies indicate that potential accidents initiated by large earthquakes are among the major contributors to public risk from nuclear power plants. During a severe earthquake, the symptoms presented to operators may be unreliable and may endanger the validity of actions in emergency response guidelines (ERGs). The objective of the present study is to improve the operator capability of responding to seismic damage through the use of ERGS. The methods used are to deterministically identify the possible weakness of ERGs, given a severe earthquake, and to probabilistically evaluate those identified weaknesses. Several cases are postulated. Each of them contains system failures with or without indicator failures and leads the core to meltdown conditions if the operator follows the ERGs strictly without any deviation. The likelihood of each case is estimated. A LISP program is developed to estimate the plant seismic risk with which the relative risk contribution of each postulated case is estimated. As a result, ten cases are postulated and possible remedies for each case are discussed. The likelihood of each case is estimated to be not negligible. The identified indicator failures should be considered in future refinement of the ERGS. The development of an expert system to provide remedial procedures should be considered after a more thorough study in which many more cases are postulated

  7. Towards a Location-based Service for Early Mental Health Interventions in Disaster Response Using Minimalistic Tele-operated Android Robots Technology

    Science.gov (United States)

    Vahidi, H.; Mobasheri, A.; Alimardani, M.; Guan, Q.; Bakillah, M.

    2014-04-01

    Providing early mental health services during disaster is a great challenge in the disaster response phase. Lack of access to adequate mental-health professionals in the early stages of large-scale disasters dramatically influences the trend of a successful mental health aid. In this paper, a conceptual framework has been suggested for adopting cellphone-type tele-operated android robots in the early stages of disasters for providing the early mental health services for disaster survivors by developing a locationbased and participatory approach. The techniques of enabling GI-services in a Peer-to-Peer (P2P) environment were studied to overcome the limitations of current centralized services. Therefore, the aim of this research study is to add more flexibility and autonomy to GI web services (WMS, WFS, WPS, etc.) and alleviate to some degree the inherent limitations of these centralized systems. A P2P system Architecture is presented for the location-based service using minimalistic tele-operated android robots, and some key techniques of implementing this service using BestPeer were studied for developing this framework.

  8. Application of Response Surface Methodology as an Efficient Approach for Optimization of Operational Variables in Benzene Hydroxylation to Phenol by V/SBA-16 Nanoporous Catalyst

    Directory of Open Access Journals (Sweden)

    Milad Jourshabani

    2016-04-01

    Full Text Available Herein, we prepared a V/SBA-16 catalyst using vanadyl acetylacetonate as a precursor and SBA-16 nanoporous silica as a support via an immobilization technique. The ordered mesoporous structure of catalyst was determined by X-ray diffraction  and transmission electron microscopy techniques , and the catalyst was evaluated in the benzene hydroxylation to phenol with hydrogen peroxide (H2O2 as a green oxidant. The effects of three key factors, namely reaction temperature (°C, H2O2 content (mL and catalyst amount (g at five levels (“1.68, “1, 0, +1, +1.68, and also their interaction on the phenol yield were investigated using response surface methodology combined with central composite design. The high correlation coefficient (R2, i.e., 0.983, showed that the data predicted using RSM were in good agreement with the experimental results. The optimization results also exhibited that high phenol yield (17.09% was achieved at the optimized values of the operating variables: the reaction temperature of 61 °C, H2O2 content of 1.69 mL and a catalyst amount of 0.1 g. In addition, response surface methodology provides a reliable method for optimizing process variables for benzene hydroxylation to phenol, with the minimum number of experiments.

  9. Influx-Operated Ca2+ Entry via PKD2-L1 and PKD1-L3 Channels Facilitates Sensory Responses to Polymodal Transient Stimuli

    Directory of Open Access Journals (Sweden)

    Mingfeng Hu

    2015-10-01

    Full Text Available The polycystic TRP subfamily member PKD2-L1, in complex with PKD1-L3, is involved in physiological responses to diverse stimuli. A major challenge to understanding whether and how PKD2-L1/PKD1-L3 acts as a bona fide molecular transducer is that recombinant channels usually respond with small or undetectable currents. Here, we discover a type of Ca2+ influx-operated Ca2+ entry (ICE that generates pronounced Ca2+ spikes. Triggered by rapid onset/offset of Ca2+, voltage, or acid stimuli, Ca2+-dependent activation amplifies a small Ca2+ influx via the channel. Ca2+ concurrently drives a self-limiting negative feedback (Ca2+-dependent inactivation that is regulated by the Ca2+-binding EF hands of PKD2-L1. Our results suggest a biphasic ICE with opposite Ca2+ feedback regulation that facilitates sensory responses to multimodal transient stimuli. We suggest that such a mechanism may also occur for other sensory modalities and other Ca2+ channels.

  10. The AFHSC-Division of GEIS Operations Predictive Surveillance Program: a multidisciplinary approach for the early detection and response to disease outbreaks.

    Science.gov (United States)

    Witt, Clara J; Richards, Allen L; Masuoka, Penny M; Foley, Desmond H; Buczak, Anna L; Musila, Lillian A; Richardson, Jason H; Colacicco-Mayhugh, Michelle G; Rueda, Leopoldo M; Klein, Terry A; Anyamba, Assaf; Small, Jennifer; Pavlin, Julie A; Fukuda, Mark M; Gaydos, Joel; Russell, Kevin L; Wilkerson, Richard C; Gibbons, Robert V; Jarman, Richard G; Myint, Khin S; Pendergast, Brian; Lewis, Sheri; Pinzon, Jorge E; Collins, Kathrine; Smith, Matthew; Pak, Edwin; Tucker, Compton; Linthicum, Kenneth; Myers, Todd; Mansour, Moustafa; Earhart, Ken; Kim, Heung Chul; Jiang, Ju; Schnabel, Dave; Clark, Jeffrey W; Sang, Rosemary C; Kioko, Elizabeth; Abuom, David C; Grieco, John P; Richards, Erin E; Tobias, Steven; Kasper, Matthew R; Montgomery, Joel M; Florin, Dave; Chretien, Jean-Paul; Philip, Trudy L

    2011-03-04

    The Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System Operations (AFHSC-GEIS) initiated a coordinated, multidisciplinary program to link data sets and information derived from eco-climatic remote sensing activities, ecologic niche modeling, arthropod vector, animal disease-host/reservoir, and human disease surveillance for febrile illnesses, into a predictive surveillance program that generates advisories and alerts on emerging infectious disease outbreaks. The program's ultimate goal is pro-active public health practice through pre-event preparedness, prevention and control, and response decision-making and prioritization. This multidisciplinary program is rooted in over 10 years experience in predictive surveillance for Rift Valley fever outbreaks in Eastern Africa. The AFHSC-GEIS Rift Valley fever project is based on the identification and use of disease-emergence critical detection points as reliable signals for increased outbreak risk. The AFHSC-GEIS predictive surveillance program has formalized the Rift Valley fever project into a structured template for extending predictive surveillance capability to other Department of Defense (DoD)-priority vector- and water-borne, and zoonotic diseases and geographic areas. These include leishmaniasis, malaria, and Crimea-Congo and other viral hemorrhagic fevers in Central Asia and Africa, dengue fever in Asia and the Americas, Japanese encephalitis (JE) and chikungunya fever in Asia, and rickettsial and other tick-borne infections in the U.S., Africa and Asia.

  11. Ginsenoside Rb1 Attenuates Agonist-Induced Contractile Response via Inhibition of Store-Operated Calcium Entry in Pulmonary Arteries of Normal and Pulmonary Hypertensive Rats

    Directory of Open Access Journals (Sweden)

    Rui-Xing Wang

    2015-03-01

    Full Text Available Background: Pulmonary hypertension (PH is characterized by sustained vasoconstriction, enhanced vasoreactivity and vascular remodeling, which leads to right heart failure and death. Despite several treatments are available, many forms of PH are still incurable. Ginsenoside Rb1, a principle active ingredient of Panax ginseng, exhibits multiple pharmacological effects on cardiovascular system, and suppresses monocrotaline (MCT-induced right heart hypertrophy. However, its effect on the pulmonary vascular functions related to PH is unknown. Methods: We examined the vasorelaxing effects of ginsenoside Rb1 on endothelin-1 (ET-1 induced contraction of pulmonary arteries (PAs and store-operated Ca2+ entry (SOCE in pulmonary arterial smooth muscle cells (PASMCs from chronic hypoxia (CH and MCT-induced PH. Results: Ginsenoside Rb1 elicited concentration-dependent relaxation of ET-1-induced PA contraction. The vasorelaxing effect was unaffected by nifedipine, but abolished by the SOCE blocker Gd3+. Ginsenoside Rb1 suppressed cyclopiazonic acid (CPA-induced PA contraction, and CPA-activated cation entry and Ca2+ transient in PASMCs. ET-1 and CPA-induced contraction, and CPA-activated cation entry and Ca2+ transients were enhanced in PA and PASMCs of CH and MCT-treated rats; the enhanced responses were abolished by ginsenoside Rb1. Conclusion: Ginsenoside Rb1 attenuates ET-1-induced contractile response via inhibition of SOCE, and it can effectively antagonize the enhanced pulmonary vasoreactivity in PH.

  12. Contaminant accumulation and biomarker responses in caged mussels, Mytilus galloprovincialis, to evaluate bioavailability and toxicological effects of remobilized chemicals during dredging and disposal operations in harbour areas

    Energy Technology Data Exchange (ETDEWEB)

    Bocchetti, Raffaella; Fattorini, Daniele; Pisanelli, Barbara [Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d' Ago, 60100 Ancona (Italy); Macchia, Simona; Oliviero, Lisa; Pilato, Fabiano; Pellegrini, David [Istituto Centrale per la Ricerca Scientifica e Tecnologica Applicata al Mare (ICRAM), Viale Nazario Sauro 4, 57128 Livorno (Italy); Regoli, Francesco [Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d' Ago, 60100 Ancona (Italy)], E-mail: f.regoli@univpm.it

    2008-09-29

    Remobilization of chemicals from contaminated sediments is a major risk associated with dredging and disposal operations in harbour areas. In this work caged mussels, Mytilus galloprovincialis, were chosen as bioindicator organisms to reveal the impact and recovery of organisms from these activities in the harbour of Piombino (Tuscany, Italy) where approximately 100,000 m{sup 3} of sediments were removed and disposed in a local confined disposal facility (CDF). Organisms were deployed before, during and after the end of operations, selecting sites differently impacted by these activities. Temporal changes in environmental bioavailability and biological effects of pollutants were assessed by integrating analyses of trace metals and polycyclic aromatic hydrocarbons (PAHs) accumulated in tissues of caged mussels with a wide array of biomarkers reflecting exposure to specific classes of pollutants and different levels of cellular unbalance or toxicity. Such biological responses included levels of metallothioneins, activity of acyl CoA oxidase (AOX) as a marker of peroxisome proliferation, oxidative stress biomarkers (content of glutathione, enzymatic activities of catalase, glutathione S-transferases, glutathione reductase, glutathione peroxidases), total oxyradical scavenging capacity (TOSC) toward peroxyl and hydroxyl radicals, lysosomal membrane stability and genotoxic effects measured as DNA strand breaks and frequency of micronuclei. Obtained results indicated that a general disturbance was already present in the whole harbour area and especially in the inner site before the beginning of operations, when caged mussels exhibited a significant accumulation of PAHs and Pb, lower TOSC values and higher levels of both lysosomal and genotoxic damages. Bioavailability of trace metals and PAHs markedly increased during dredging activities with values up to 40 {mu}g/g for Pb and up to 2200 ng/g for PAHs in tissues of caged mussels, a significant inhibition of antioxidant

  13. Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU.

    Science.gov (United States)

    Pottenger, Lynn H; Schisler, Melissa R; Zhang, Fagen; Bartels, Michael J; Fontaine, Donald D; McFadden, Lisa G; Bhaskar Gollapudi, B

    2009-08-01

    The dose-response relationships for in vitro mutagenicity induced by methylmethanesulfonate (MMS) or methylnitrosourea (MNU) in L5178Y mouse lymphoma (ML) cells were examined. DNA adducts (N7-methylguanine, N7MeG and O(6)-methylguanine, O(6)MeG) were quantified as biomarkers of exposure. Both endpoints were assessed using 5replicates/dose (4-h treatment) with MMS or MNU (0.0069-50muM), or vehicle (1% DMSO). Mutant frequency (MF) (thymidine kinase (TK) locus) was determined using the soft agar cloning methodology and a 2-day expression period; in addition, microwell and Sequester-Express-Select (SES) methods were used for MMS. Isolated DNA was acid-hydrolyzed, and adducts quantified by LC/ESI-MS/MS, using authentic and internal standards. MF dose-responses were analyzed using several statistical approaches, all of which confirmed that a threshold dose-response model provided the best fit. NOAELs for MF were 10muM MMS and 0.69muM MNU, based on ANOVA and Dunnett's test (p/=10muM MMS or 3.45muM MNU. O(6)MeG levels were only quantifiable at >/=10muM MNU; O(6)MeG was not quantifiable in control or MMS-treated cells at current detection limits. Thus, (1) cells treated with MMS did not demonstrate increases in TK(-) MF, but did demonstrate quantifiable levels of N7MeG adducts; and (2) the levels of N7MeG adducts did not correlate with induced MF, as MNU-treated cells had fewer N7MeG adducts but higher MF compared with MMS-treated cells, for quasi-equimolar doses. Taken together, these results demonstrate operational thresholds, defined as the highest dose for which the response is not significantly (statistically or biologically) distinguishable from the control/background values, for induction of mutations and N7MeG adducts in ML cells treated with MMS or MNU, and a lack of correlation between induced MF and levels of N7MeG adducts.

  14. Correlation of free-response and receiver-operating-characteristic area-under-the-curve estimates: Results from independently conducted FROC/ROC studies in mammography

    International Nuclear Information System (INIS)

    Zanca, Federica; Hillis, Stephen L.; Claus, Filip; Van Ongeval, Chantal; Celis, Valerie; Provoost, Veerle; Yoon, Hong-Jun; Bosmans, Hilde

    2012-01-01

    Purpose: From independently conducted free-response receiver operating characteristic (FROC) and receiver operating characteristic (ROC) experiments, to study fixed-reader associations between three estimators: the area under the alternative FROC (AFROC) curve computed from FROC data, the area under the ROC curve computed from FROC highest rating data, and the area under the ROC curve computed from confidence-of-disease ratings. Methods: Two hundred mammograms, 100 of which were abnormal, were processed by two image-processing algorithms and interpreted by four radiologists under the FROC paradigm. From the FROC data, inferred-ROC data were derived, using the highest rating assumption. Eighteen months afterwards, the images were interpreted by the same radiologists under the conventional ROC paradigm; conventional-ROC data (in contrast to inferred-ROC data) were obtained. FROC and ROC (inferred, conventional) data were analyzed using the nonparametric area-under-the-curve (AUC), (AFROC and ROC curve, respectively). Pearson correlation was used to quantify the degree of association between the modality-specific AUC indices and standard errors were computed using the bootstrap-after-bootstrap method. The magnitude of the correlations was assessed by comparison with computed Obuchowski-Rockette fixed reader correlations. Results: Average Pearson correlations (with 95% confidence intervals in square brackets) were: Corr(FROC, inferred ROC) = 0.76[0.64, 0.84] > Corr(inferred ROC, conventional ROC) = 0.40[0.18, 0.58] > Corr (FROC, conventional ROC) = 0.32[0.16, 0.46]. Conclusions: Correlation between FROC and inferred-ROC data AUC estimates was high. Correlation between inferred- and conventional-ROC AUC was similar to the correlation between two modalities for a single reader using one estimation method, suggesting that the highest rating assumption might be questionable.

  15. Effects of acetic acid injection and operating conditions on NO emission in a vortexing fluidized bed combustor using response surface methodology

    Energy Technology Data Exchange (ETDEWEB)

    Fuping Qian; Chiensong Chyang; Weishen Yen [Anhui University of Technology, Ma' anshan (China). School of Civil Engineering and Architecture

    2009-07-15

    The effects of acetic acid injection and operating conditions on NO emission were investigated in a pilot scale vortexing fluidized bed combustor (VFBC), an integration of circular freeboard and a rectangular combustion chamber. Operating conditions, such as the stoichiometric oxygen in the combustion chamber, the bed temperature and the injecting location of acetic acid, were determined by means of response surface methodology (RSM), which enables the examination of parameters with a moderate number of experiments. In RSM, NO emission concentration after acetic acid injection and NO removal percentage at the exit of the VFBC are used as the objective function. The results show that the bed temperature has a more important effect on the NO emission than the injecting location of acetic acid and the stoichiometric oxygen in the combustion chamber. Meanwhile, the injecting location of acetic acid and the stoichiometric oxygen in the combustion chamber have a more important effect on the NO removal percentage than the bed temperature. NO emission can be decreased by injecting the acetic acid into the combustion chamber, and NO emission decreases with the height of the acetic acid injecting location above the distributor. On the other hand, NO removal percentage increases with the height of the acetic acid injecting location, and NO emission increases with the stoichiometric oxygen in the combustion chamber and the bed temperature. NO removal percentage increases with the stoichiometric oxygen, and increases first, then decreases with the bed temperature. Also, a higher NO removal percentage could be obtained at 850{sup o}C. 26 refs., 12 figs., 8 tabs.

  16. Deepwater Horizon MC252 response operations data from the Environmental Response Management Application (ERMA) containing dispersant operations and related data collected during the DWH response between 2010-04-22 to 2010-07-19 in the Northern Gulf of Mexico (NCEI Accession 0163801)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Archival Information Package (AIP) contains Environmental Resource Management Application (ERMA) GIS layers that represent dispersant operation datasets...

  17. Analytical Kinematics and Coupled Vibrations Analysis of Mechanical System Operated by Solar Array Drive Assembly

    Science.gov (United States)

    Sattar, M.; Wei, C.; Jalali, A.; Sattar, R.

    2017-07-01

    To address the impact of solar array (SA) anomalies and vibrations on performance of precision space-based operations, it is important to complete its accurate jitter analysis. This work provides mathematical modelling scheme to approximate kinematics and coupled micro disturbance dynamics of rigid load supported and operated by solar array drive assembly (SADA). SADA employed in analysis provides a step wave excitation torque to activate the system. Analytical investigations into kinematics is accomplished by using generalized linear and Euler angle coordinates, applying multi-body dynamics concepts and transformations principles. Theoretical model is extended, to develop equations of motion (EoM), through energy method (Lagrange equation). The main emphasis is to research coupled frequency response by determining energies dissipated and observing dynamic behaviour of internal vibratory systems of SADA. The disturbance model captures discrete active harmonics of SADA, natural modes and vibration amplifications caused by interactions between active harmonics and structural modes of mechanical assembly. The proposed methodology can help to predict true micro disturbance nature of SADA operating rigid load. Moreover, performance outputs may be compared against actual mission requirements to assess precise spacecraft controller design to meet next space generation stringent accuracy goals.

  18. Technical Concept - Operation Bren

    Science.gov (United States)

    1962-01-01

    and consonant with safe operation of those facilities. C-1, C-4, and C-6 (see the organization chart on p. 20) shall be responsible to the TD for...source will be shipped to NTS in accordance with AEC regulations. 19 Chapter 8 ORGANIZATION AND RESPONSIBILITIES The organization chart for Operation

  19. ON THE PRO-METASTATIC STRESS RESPONSE TO CANCER THERAPIES: EVIDENCE FOR A POSITIVE CO-OPERATION BETWEEN TIMP-1, HIF-1α, AND miR-210

    Directory of Open Access Journals (Sweden)

    Haissi eCui

    2012-07-01

    Full Text Available In contrast to expectations in the past that tumor starvation or unselective inhibition of proteolytic activity would cure cancer, there is accumulating evidence that microenvironmental stress, such as hypoxia or broad spectrum inhibition of metalloproteinases can promote metastasis. In fact, malignant tumor cells, due to their genetic and epigenetic instability, are predisposed to react to stress by adaptation and, if the stress persists, by escape and formation of metastasis. Recent recognition of the concepts of dynamic evolution as well as population and systems biology is extremely helpful to understand the disappointments of clinical trials with new drugs and may lead to paradigm-shifts in therapy strategies. This must be complemented by an increased understanding of molecular mechanism involved in stress response. Here, we review new roles of Hypoxia-inducible factor-1 (HIF-1, one transcription factor regulating stress response-related gene expression: HIF-1 is crucial for invasion and metastasis, independent from its pro-survival function. In addition, HIF-1 mediates pro-metastatic microenvironmental changes of the proteolytic balance as triggered by high systemic levels of tissue inhibitor of metalloproteinases-1 (TIMP-1, typical for many aggressive cancers, and regulates the metabolic switch to glycolysis, notably via activation of the microRNA miR-210. There is preliminary evidence that TIMP-1 also induces miR-210. Such positive-regulatory co-operation of HIF-1α, miR-210, and TIMP-1, all described to correlate with bad prognosis of cancer patients, opens new perspectives of gaining insight into molecular mechanisms of metastasis-inducing evasion of tumor cells from stress.

  20. Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex and operant responses to aversive cold after CFA inflammation.

    Science.gov (United States)

    Lemons, L L; Wiley, R G

    2012-08-02

    The spinal Neuropeptide Y (NPY) system is a potential target for development of new pain therapeutics. NPY and two of its receptors (Y1 and Y2) are found in the superficial dorsal horn of the spinal cord, a key area of nociceptive gating and modulation. Lumbar intrathecal injection of (NPY) is antinociceptive, reducing hyper-reflexia to thermal and mechanical stimulation, particularly after nerve injury and inflammation. We have also shown that intrathecal injection of the targeted cytotoxin, Neuropeptide Y-sap (NPY-sap), is also antinociceptive, reducing nocifensive reflex responses to noxious heat and formalin. In the present study, we sought to determine the role of dorsal horn Y1R-expressing neurons in pain by destroying them with NPY-sap and testing the rats on three operant tasks. Lumbar intrathecal NPY-sap (1) reduced Complete Freund's Adjuvant (CFA)-induced hyper-reflexia on the 10°C cold plate, (2) reduced cold aversion on the thermal preference and escape tasks, (3) was analgesic to noxious heat on the escape task, (4) reduced the CFA-induced allodynia to cold temperatures experienced on the thermal preference, feeding interference, and escape tasks, and (5) did not inhibit or interfere with morphine analgesia. Published by Elsevier Ltd.

  1. Standard operating procedures for collection of soil and sediment samples for the Sediment-bound Contaminant Resiliency and Response (SCoRR) strategy pilot study

    Science.gov (United States)

    Fisher, Shawn C.; Reilly, Timothy J.; Jones, Daniel K.; Benzel, William M.; Griffin, Dale W.; Loftin, Keith A.; Iwanowicz, Luke R.; Cohl, Jonathan A.

    2015-12-17

    An understanding of the effects on human and ecological health brought by major coastal storms or flooding events is typically limited because of a lack of regionally consistent baseline and trends data in locations proximal to potential contaminant sources and mitigation activities, sensitive ecosystems, and recreational facilities where exposures are probable. In an attempt to close this gap, the U.S. Geological Survey (USGS) has implemented the Sediment-bound Contaminant Resiliency and Response (SCoRR) strategy pilot study to collect regional sediment-quality data prior to and in response to future coastal storms. The standard operating procedure (SOP) detailed in this document serves as the sample-collection protocol for the SCoRR strategy by providing step-by-step instructions for site preparation, sample collection and processing, and shipping of soil and surficial sediment (for example, bed sediment, marsh sediment, or beach material). The objectives of the SCoRR strategy pilot study are (1) to create a baseline of soil-, sand-, marsh sediment-, and bed-sediment-quality data from sites located in the coastal counties from Maine to Virginia based on their potential risk of being contaminated in the event of a major coastal storm or flooding (defined as Resiliency mode); and (2) respond to major coastal storms and flooding by reoccupying select baseline sites and sampling within days of the event (defined as Response mode). For both modes, samples are collected in a consistent manner to minimize bias and maximize quality control by ensuring that all sampling personnel across the region collect, document, and process soil and sediment samples following the procedures outlined in this SOP. Samples are analyzed using four USGS-developed screening methods—inorganic geochemistry, organic geochemistry, pathogens, and biological assays—which are also outlined in this SOP. Because the SCoRR strategy employs a multi-metric approach for sample analyses, this

  2. Stakeholders' Engagement Methods for the Mining Social Responsibility Practice: Determination of Local Issues and Concerns Related to the Mines Operations in Northwest of the US.

    Science.gov (United States)

    Masaitis, A.

    2014-12-01

    Every year, all around the world, global environmental change affects the human habitat. This is effect enhanced by the mining operation, and creates new challenges in relationship between the mining and local community. The purpose of this project are developed the Stakeholders engagement evaluation plan which is currently developed in University of Nevada, Reno for the Emigrant mining project, located in the central Nevada, USA, and belong to the Newmont Mining Corporation, one of the gold production leader worldwide. The needs for this project is to create the open dialog between Newmont mining company and all interested parties which have social or environmental impacts from the Emigrant mine. Identification of the stakeholders list is first and one of the most difficult steps in the developing of mine social responsibility. Stakeholders' engagement evaluation plan must be based on the timing and available resources of the mining company, understanding the goals for the engagement, and on analyzes of the possible risks from engagement. In conclusion, the Stakeholders engagement evaluation plan includes: first, determinations of the stakeholders list, which must include any interested or effected by the mine projects groups, for example: state and local government representatives, people from local communities, business partners, environmental NGOs, indigenous people, and academic groups. The contacts and availability for communication is critical for Stakeholders engagement. Next, is to analyze characteristics of all these parties and determinate the level of interest and level of their influence on the project. The next step includes the Stakeholders matrix and mapping development, where all these information will be put together.After that, must be chosen the methods for stakeholders' engagement. The methods usually depends from the goals of engagement (create the dialog lines, collect the data, determinations of the local issues and concerns, or establish

  3. Cask fleet operations study

    Energy Technology Data Exchange (ETDEWEB)

    1988-01-01

    The Nuclear Waste Policy Act of 1982 assigned to the Department of Energy's (DOE) Office of Civilian Waste Management the responsibility for disposing of high-level waste and spent fuel. A significant part of that responsibility involves transporting nuclear waste materials within the federal waste management system; that is, from the waste generator to the repository. The lead responsibility for transportation operations has been assigned to Oak Ridge Operations, with Oak Ridge National Laboratory (ORNL) providing technical support through the Transportation Operations Support Task Group. One of the ORNL support activities involves assessing what facilities, equipment and services are required to assure that an acceptable, cost-effective and safe transportation operations system can be designed, operated and maintained. This study reviews, surveys and assesses the experience of Nuclear Assurance Corporation (NAC) in operating a fleet of spent-fuel shipping casks to aid in developing the spent-fuel transportation system.

  4. Cask fleet operations study

    International Nuclear Information System (INIS)

    1988-01-01

    The Nuclear Waste Policy Act of 1982 assigned to the Department of Energy's (DOE) Office of Civilian Waste Management the responsibility for disposing of high-level waste and spent fuel. A significant part of that responsibility involves transporting nuclear waste materials within the federal waste management system; that is, from the waste generator to the repository. The lead responsibility for transportation operations has been assigned to Oak Ridge Operations, with Oak Ridge National Laboratory (ORNL) providing technical support through the Transportation Operations Support Task Group. One of the ORNL support activities involves assessing what facilities, equipment and services are required to assure that an acceptable, cost-effective and safe transportation operations system can be designed, operated and maintained. This study reviews, surveys and assesses the experience of Nuclear Assurance Corporation (NAC) in operating a fleet of spent-fuel shipping casks to aid in developing the spent-fuel transportation system

  5. Ring vaccination with rVSV-ZEBOV under expanded access in response to an outbreak of Ebola virus disease in Guinea, 2016: an operational and vaccine safety report.

    Science.gov (United States)

    Gsell, Pierre-Stéphane; Camacho, Anton; Kucharski, Adam J; Watson, Conall H; Bagayoko, Aminata; Nadlaou, Séverine Danmadji; Dean, Natalie E; Diallo, Abdourahamane; Diallo, Abdourahmane; Honora, Djidonou A; Doumbia, Moussa; Enwere, Godwin; Higgs, Elizabeth S; Mauget, Thomas; Mory, Diakite; Riveros, Ximena; Oumar, Fofana Thierno; Fallah, Mosoka; Toure, Alhassane; Vicari, Andrea S; Longini, Ira M; Edmunds, W J; Henao-Restrepo, Ana Maria; Kieny, Marie Paule; Kéïta, Sakoba

    2017-12-01

    In March, 2016, a flare-up of Ebola virus disease was reported in Guinea, and in response ring vaccination with the unlicensed rVSV-ZEBOV vaccine was introduced under expanded access, the first time that an Ebola vaccine has been used in an outbreak setting outside a clinical trial. Here we describe the safety of rVSV-ZEBOV candidate vaccine and operational feasibility of ring vaccination as a reactive strategy in a resource-limited rural setting. Approval for expanded access and compassionate use was rapidly sought and obtained from relevant authorities. Vaccination teams and frozen vaccine were flown to the outbreak settings. Rings of contacts and contacts of contacts were defined and eligible individuals, who had given informed consent, were vaccinated and followed up for 21 days under good clinical practice conditions. Between March 17 and April 21, 2016, 1510 individuals were vaccinated in four rings in Guinea, including 303 individuals aged between 6 years and 17 years and 307 front-line workers. It took 10 days to vaccinate the first participant following the confirmation of the first case of Ebola virus disease. No secondary cases of Ebola virus disease occurred among the vaccinees. Adverse events following vaccination were reported in 47 (17%) 6-17 year olds (all mild) and 412 (36%) adults (individuals older than 18 years; 98% were mild). Children reported fewer arthralgia events than adults (one [Ebola virus disease outbreaks in rural settings. WHO, Gavi, and the World Food Programme. Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.

  6. Biometrics and Policing: A Protocol for Multichannel Sensor Data Collection and Exploratory Analysis of Contextualized Psychophysiological Response During Law Enforcement Operations.

    Science.gov (United States)

    Furberg, Robert D; Taniguchi, Travis; Aagaard, Brian; Ortiz, Alexa M; Hegarty-Craver, Meghan; Gilchrist, Kristin H; Ridenour, Ty A

    2017-03-17

    Stress experienced by law enforcement officers is often extreme and is in many ways unique among professions. Although past research on officer stress is informative, it is limited, and most studies measure stress using self-report questionnaires or observational studies that have limited generalizability. We know of no research studies that have attempted to track direct physiological stress responses in high fidelity, especially within an operational police setting. The outcome of this project will have an impact on both practitioners and policing researchers. To do so, we will establish a capacity to obtain complex, multisensor data; process complex datasets; and establish the methods needed to conduct idiopathic clinical trials on behavioral interventions in similar contexts. The objective of this pilot study is to demonstrate the practicality and utility of wrist-worn biometric sensor-based research in a law enforcement agency. We will use nonprobability convenience-based sampling to recruit 2-3 participants from the police department in Durham, North Carolina, USA. Data collection was conducted in 2016. We will analyze data in early 2017 and disseminate our results via peer reviewed publications in late 2017. We developed the Biometrics & Policing Demonstration project to provide a proof of concept on collecting biometric data in a law enforcement setting. This effort will enable us to (1) address the regulatory approvals needed to collect data, including human participant considerations, (2) demonstrate the ability to use biometric tracking technology in a policing setting, (3) link biometric data to law enforcement data, and (4) explore project results for law enforcement policy and training. ©Robert D Furberg, Travis Taniguchi, Brian Aagaard, Alexa M Ortiz, Meghan Hegarty-Craver, Kristin H Gilchrist, Ty A Ridenour. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 17.03.2017.

  7. Volunteer trials of a novel improvised dry decontamination protocol for use during mass casualty incidents as part of the UK'S Initial Operational Response (IOR.

    Directory of Open Access Journals (Sweden)

    Richard Amlôt

    Full Text Available Previous studies have demonstrated that rapid evacuation, disrobing and emergency decontamination can enhance the ability of emergency services and acute hospitals to effectively manage chemically-contaminated casualties. The purpose of this human volunteer study was to further optimise such an "Initial Operational Response" by (1 identifying an appropriate method for performing improvised skin decontamination and (2 providing guidance for use by first responders and casualties. The study was performed using two readily available, absorbent materials (paper towels and incontinence pads. The decontamination effectiveness of the test materials was measured by quantifying the amount of a chemical warfare agent simulant (methyl salicylate removed from each volunteer's forearm skin. Results from the first study demonstrated that simulant recovery was lower in all of the dry decontamination conditions when compared to matched controls, suggesting that dry decontamination serves to reduce chemical exposure. Blotting in combination with rubbing was the most effective form of decontamination. There was no difference in effectiveness between the two absorbent materials. In the following study, volunteers performed improvised dry decontamination, either with or without draft guidelines. Volunteers who received the guidance were able to carry out improvised dry decontamination more effectively, using more of the absorbent product (blue roll to ensure that all areas of the body were decontaminated and avoiding cross-contamination of other body areas by working systematically from the head downwards. Collectively, these two studies suggest that absorbent products that are available on ambulances and in acute healthcare settings may have generic applicability for improvised dry decontamination. Wherever possible, emergency responders and healthcare workers should guide casualties through decontamination steps; in the absence of explicit guidance and

  8. Pre-emptive intraperitoneal local anaesthesia: an effective method in immediate post-operative pain management and metabolic stress response in laparoscopic appendicectomy, a randomized, double-blinded, placebo-controlled study.

    Science.gov (United States)

    Thanapal, Mohana Raj; Tata, Mahadevan D; Tan, Ann J; Subramaniam, Thiruselvi; Tong, Jenny M G; Palayan, Kandasami; Rampal, Sanjay; Gurunathan, Ramesh

    2014-01-01

    Although laparoscopic surgeries are associated with reduced surgical stress response and shortened post-operative recovery, intense pain and high analgesia requirements in the immediate post-operative period are often the chief complaints. The aim of this study was to evaluate the effect of pre-emptive intraperitoneal local anaesthetic drugs on post-operative pain management and metabolic stress response in laparoscopic appendicectomy. The method used was a randomized double-blinded placebo-controlled study. Patients with clinical diagnosis of acute appendicitis who fulfil the criteria, were taken into this study. Primary outcomes investigated were consumption of patient-controlled analgesia during the immediate post-operative period (first 6 h) and subsequent 18 h as well as serum cortisol sampling. Total of 120 patients were recruited into three different treatment groups (placebo, ropivacaine, levobupivacaine). In order to maintain visual analogue score of 0-1 during the immediate post-operative period, patients in the placebo group required significantly (P metabolic stress response of the body. © 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.

  9. Usefulness of cardiac magnetic resonance imaging combined with low-dose dobutamine stress to detect an abnormal ventricular stress response in children and young adults after fontan operation at young age.

    NARCIS (Netherlands)

    Robbers-Visser, D.; Harkel, D Jan Ten; Kapusta, L.; Strengers, J.L.; Dalinghaus, M.; Meijboom, F.J.; Pattynama, P.M.; Bogers, A.J.; Helbing, W.A.

    2008-01-01

    After Fontan operation, patients are limited in increasing cardiac output and in exercise capacity. This has been related to impaired preload or other factors leading to decreased global ventricular performance with stress. To study these factors, the stress responses of functionally univentricular

  10. Operational Windows for Dry-Wall and Wetted-Wall IFE Chambers

    International Nuclear Information System (INIS)

    Najmabadi, F.; Raffray, A.R.; Bromberg, L.

    2004-01-01

    The ARIES-IFE study was an integrated study of inertial fusion energy (IFE) chambers and chamber interfaces with the driver and target systems. Detailed analysis of various subsystems was performed parametrically to uncover key physics/technology uncertainties and to identify constraints imposed by each subsystem. In this paper, these constraints (e.g., target injection and tracking, thermal response of the first wall, and driver propagation and focusing) were combined to understand the trade-offs, to develop operational windows for chamber concepts, and to identify high-leverage research and development directions for IFE research. Some conclusions drawn in this paper are (a) the detailed characterization of the target yield and spectrum has a major impact on the chamber; (b) it is prudent to use a thin armor instead of a monolithic first wall for dry-wall concepts; (c) for dry-wall concepts with direct-drive targets, the most stringent constraint is imposed by target survival during the injection process; (d) for relatively low yield targets (<250 MJ), an operational window with no buffer gas may exist; (e) for dry-wall concepts with indirect-drive targets, a high buffer gas pressure would be necessary that may preclude propagation of the laser driver and require assisted pinch transport for the heavy-ion driver; and (f) generation and transport of aerosols in the chamber is the key feasibility issue for wetted-wall concepts

  11. Operational Control Procedures for the Activated Sludge Process, Part III-B: Calculation Procedures for Step-Feed Process Responses and Addendum No. 1.

    Science.gov (United States)

    West, Alfred W.

    This is the third in a series of documents developed by the National Training and Operational Technology Center describing operational control procedures for the activated sludge process used in wastewater treatment. This document deals with the calculation procedures associated with a step-feed process. Illustrations and examples are included to…

  12. Information Operations: Where Next?

    National Research Council Canada - National Science Library

    Buchholz, David R

    2005-01-01

    ... to standardized IO training and integration across the combatant commands. For this reason and others there is a compelling argument for the major responsibility for DoD information operations integration to fall under the control of U.S...

  13. Information Operations: Where Next?

    National Research Council Canada - National Science Library

    Buchholz, David R

    2005-01-01

    ... (DoD) information operations. Doctrine already addresses the issue of combatant commander responsibility for ensuring that IO is planned and executed in the respective commands, but an IO vacuum exists with respect...

  14. Securing Mobile Networks in an Operational Setting

    Science.gov (United States)

    Ivancic, William D.; Stewart, David H.; Bell, Terry L.; Paulsen, Phillip E.; Shell, Dan

    2004-01-01

    This paper describes a network demonstration and three month field trial of mobile networking using mobile-IPv4. The network was implemented as part of the US Coast Guard operational network which is a ".mil" network and requires stringent levels of security. The initial demonstrations took place in November 2002 and a three month field trial took place from July through September of 2003. The mobile network utilized encryptors capable of NSA-approved Type 1 algorithms, mobile router from Cisco Systems and 802.11 and satellite wireless links. This paper also describes a conceptual architecture for wide-scale deployment of secure mobile networking in operational environments where both private and public infrastructure is used. Additional issues presented include link costs, placement of encryptors and running routing protocols over layer-3 encryption devices.

  15. Operational amplifiers

    CERN Document Server

    Dostal, Jiri

    1993-01-01

    This book provides the reader with the practical knowledge necessary to select and use operational amplifier devices. It presents an extensive treatment of applications and a practically oriented, unified theory of operational circuits.Provides the reader with practical knowledge necessary to select and use operational amplifier devices. Presents an extensive treatment of applications and a practically oriented, unified theory of operational circuits

  16. Spatial Operations

    Directory of Open Access Journals (Sweden)

    Anda VELICANU

    2010-09-01

    Full Text Available This paper contains a brief description of the most important operations that can be performed on spatial data such as spatial queries, create, update, insert, delete operations, conversions, operations on the map or analysis on grid cells. Each operation has a graphical example and some of them have code examples in Oracle and PostgreSQL.

  17. Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.

    Directory of Open Access Journals (Sweden)

    Nicola Gagliani

    Full Text Available BACKGROUND: A large pool of preexisting alloreactive effector T cells can cause allogeneic graft rejection following transplantation. However, it is possible to induce transplant tolerance by altering the balance between effector and regulatory T (Treg cells. Among the various Treg-cell types, Foxp3(+Treg and IL-10-producing T regulatory type 1 (Tr1 cells have frequently been associated with tolerance following transplantation in both mice and humans. Previously, we demonstrated that rapamycin+IL-10 promotes Tr1-cell-associated tolerance in Balb/c mice transplanted with C57BL/6 pancreatic islets. However, this same treatment was unsuccessful in C57BL/6 mice transplanted with Balb/c islets (classified as a stringent transplant model. We accordingly designed a protocol that would be effective in the latter transplant model by simultaneously depleting effector T cells and fostering production of Treg cells. We additionally developed and tested a clinically translatable protocol that used no depleting agent. METHODOLOGY/PRINCIPAL FINDINGS: Diabetic C57BL/6 mice were transplanted with Balb/c pancreatic islets. Recipient mice transiently treated with anti-CD45RB mAb+rapamycin+IL-10 developed antigen-specific tolerance. During treatment, Foxp3(+Treg cells were momentarily enriched in the blood, followed by accumulation in the graft and draining lymph node, whereas CD4(+IL-10(+IL-4(- T (i.e., Tr1 cells localized in the spleen. In long-term tolerant mice, only CD4(+IL-10(+IL-4(- T cells remained enriched in the spleen and IL-10 was key in the maintenance of tolerance. Alternatively, recipient mice were treated with two compounds routinely used in the clinic (namely, rapamycin and G-CSF; this drug combination promoted tolerance associated with CD4(+IL-10(+IL-4(- T cells. CONCLUSIONS/SIGNIFICANCE: The anti-CD45RB mAb+rapamycin+IL-10 combined protocol promotes a state of tolerance that is IL-10 dependent. Moreover, the combination of rapamycin+G-CSF induces

  18. Long-term global response analysis of a vertical axis wind turbine supported on a semi-submersible floating platform: Comparison between operating and non-operating wind turbine load cases

    DEFF Research Database (Denmark)

    Collu, Maurizio; Manuel, Lance; Borg, Michael

    2015-01-01

    is adopted, as well as also taking into account the drag generated by the wind turbine tower. Short-term turbine load and platform motion statistics are established for individual sea states that are analysed. The long-term reliability yields estimates of 50-year loads and platform motions that takes......This study continues [1] the examination of the long-term global response of a floating vertical axis wind turbine (VAWT) situated off the Portuguese coast in the Atlantic Ocean. The VAWT, which consists of a 5-MW 3-bladed H-type rotor developed as part of the EU-FP7 H2OCEAN project, is assumed...... into consideration response statistics from the simulations as well as the metocean (wind-wave) data and distributions. The results show that it is not necessarily the load cases associated with the highest wind speed that lead to the highest displacements and tensions in the mooring lines; differences among...

  19. Temperature and salinity profile data collected by NOAA's Navigation Response Team 5 during operations along the northeast US coast, March 2005 - March 2006 (NODC Accession 0002674)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature profile data were collected using CTD casts in the Northwest Atlantic Ocean and the Northeast US Coast from the NAVIGATION RESPONSE TEAM 5 from 03 March...

  20. Draft final feasibility study report and proposed plan for Operable Unit 4, response to comments: Fernald Environmental Management Project, Fernald, Ohio

    International Nuclear Information System (INIS)

    1994-02-01

    This report contains questions and comments regarding a risk evaluation and possible remedial action of Operable Unit 4 at the Feed Materials Production Center at Fernald, Ohio. Attention is focused on the US EPA Region V feasibility study and on the CRARE. The CRARE is a post-remediation time frame document

  1. The IDA cognitive model for the analysis of nuclear power plant operator response under accident conditions. Part I: problem solving and decision making model

    International Nuclear Information System (INIS)

    Smidts, C.; Shen, S.H.; Mosleh, A.

    1997-01-01

    This paper is the first of a series of papers describing IDA which is a cognitive model for analysing the behaviour of nuclear power plant operators under accident conditions. The domain of applicability of the model is a relatively constrained environment where behaviour is significantly influenced by high levels of training and explicit requirement to follow written procedures. IDA consists of a model for individual operator behaviour and a model for control room operating crew expanded from the individual model. The model and its derivatives such as an error taxonomy and data collection approach has been designed with ultimate objective of becoming a quantitative method for human reliability analysis (HRA) in probabilistic risk assessment (PRA). The present paper gives a description of the main components of IDA such as memory structure, goals, and problem solving and decision making strategies. It also identifies factors that are at the origin of transitions between goals or between strategies. These factors cover the effects of external conditions and psychological state of the operator. The description is generic at first and then made specific to the nuclear power plant environment and more precisely to abnormal conditions

  2. Draft final feasibility study report and proposed plan for Operable Unit 4, response to comments: Fernald Environmental Management Project, Fernald, Ohio

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    This report contains questions and comments regarding a risk evaluation and possible remedial action of Operable Unit 4 at the Feed Materials Production Center at Fernald, Ohio. Attention is focused on the US EPA Region V feasibility study and on the CRARE. The CRARE is a post-remediation time frame document.

  3. pseudomonotone operators

    Directory of Open Access Journals (Sweden)

    Ram U. Verma

    2000-01-01

    Full Text Available We present the solvability of a class of nonlinear variational inequalities involving pseudomonotone operators in a locally convex Hausdorff topological vector spaces setting. The obtained result generalizes similar variational inequality problems on monotone operators.

  4. Operating experience with steam generators

    International Nuclear Information System (INIS)

    Bouecke, R.

    1991-01-01

    In contrast to steam generator tube degradation problems that have been widely encountered worldwide, steam generators of the Siemens/KWU design have proven by operating experience that they are very efficient in minimizing tube corrosion or any other SG related problems. The paper will substantiate this statement by addressing the performance characteristics of nearly 20 years of operation experience. Emphasis is put on evaluations comparing the heat transfer capacity of Incoloy 800 with that of Inconel 690 TT. Various tube support designs are discussed with respect to hide-out behaviour. Recent evaluations confirm the superiority of grid type tube support designs compared to tube support plates. Anti vibration bars acc. to Siemens/KWU design allow proper support even of the innermost U-tubes, by which excessive vibration induced tube failures due to fatigue are ruled-out. Steam generators are key components which can heavily effect plant safety and availability. This was recognized by Siemens/KWU at a very early stage of the SG design. A multi level concept was developed and consequently applied, the characteristics of which can be highlighted as follows: - Implementation of specific design features after careful experimental and/or analytical verification; - Material selection based on profound validation tests; - Stringent inspection requirements regarding control of manufacturing; - Deliberate specification and control of water chemistry guidelines; - Close feedback of operational problems to be readily considered in design improvements or remedial actions to be taken. A strict application of this concept has reached a stage which allows the following summarizing statements: - All main design features of the Siemens/KWU SG are in use - basically unchanged - for roughly 20 years; - All of them are verified by excellent operating experience and available for implementation in any replacement or new SG design; - No need for replacement of Siemens/KWU SG is

  5. Operating systems

    CERN Document Server

    Tsichritzis, Dionysios C; Rheinboldt, Werner

    1974-01-01

    Operating Systems deals with the fundamental concepts and principles that govern the behavior of operating systems. Many issues regarding the structure of operating systems, including the problems of managing processes, processors, and memory, are examined. Various aspects of operating systems are also discussed, from input-output and files to security, protection, reliability, design methods, performance evaluation, and implementation methods.Comprised of 10 chapters, this volume begins with an overview of what constitutes an operating system, followed by a discussion on the definition and pr

  6. Operational calculus

    CERN Document Server

    Boehme, Thomas K

    1987-01-01

    Operational Calculus, Volume II is a methodical presentation of operational calculus. An outline of the general theory of linear differential equations with constant coefficients is presented. Integral operational calculus and advanced topics in operational calculus, including locally integrable functions and convergence in the space of operators, are also discussed. Formulas and tables are included.Comprised of four sections, this volume begins with a discussion on the general theory of linear differential equations with constant coefficients, focusing on such topics as homogeneous and non-ho

  7. Schwartz operators

    Science.gov (United States)

    Keyl, M.; Kiukas, J.; Werner, R. F.

    2016-05-01

    In this paper, we introduce Schwartz operators as a non-commutative analog of Schwartz functions and provide a detailed discussion of their properties. We equip them, in particular, with a number of different (but equivalent) families of seminorms which turns the space of Schwartz operators into a Fréchet space. The study of the topological dual leads to non-commutative tempered distributions which are discussed in detail as well. We show, in particular, that the latter can be identified with a certain class of quadratic forms, therefore making operations like products with bounded (and also some unbounded) operators and quantum harmonic analysis available to objects which are otherwise too singular for being a Hilbert space operator. Finally, we show how the new methods can be applied by studying operator moment problems and convergence properties of fluctuation operators.

  8. Public comments on the proposed 10 CFR Part 51 rule for renewal of nuclear power plant operating licenses and supporting documents: Review of concerns and NRC staff response. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    This report documents the Nuclear Regulatory Commission (NRC) staff review of public comments provided in response to the NRC`s proposed amendments to 10 Code of Federal Regulations (CFR) Part 51, which establish new requirements for the environmental review of applications for the renewal of operating licenses of nuclear power plants. The public comments include those submitted in writing, as well as those provided at public meetings that were held with other Federal agencies, State agencies, nuclear industry representatives, public interest groups, and the general public. This report also contains the NRC staff response to the various concerns raised, and highlights the changes made to the final rule and the supporting documents in response to these concerns.

  9. Assessment of the environmental impact statement for the proposed expansion of the Olympic Dam operations at Roxby Downs

    International Nuclear Information System (INIS)

    1997-01-01

    This Environmental Assessment Report assesses the social, environmental and economic impact of the proposal by Western Mining Corporation (Olympic Dam Corporation) Pty Ltd. (WMC) to increase their production at Olympic Dam mine from 150,000t/a of copper and associated products to 350,000t/a by a phased expansion. The first phase would take production to approximately 200,000t/a. The report reviews the 1997 Environmental Impact Statement (EIS), public comments on the EIS, and the proponent's responses to these comments in the Supplement to the EIS. It also relies on information, comments and advice provided by appropriate South Australian and Commonwealth government agencies (through the joint assessment process) and previous studies undertaken in the region.The focus of the contents of this assessment report are: water usage; tailing management; radiation management; economic and employment estimates; EIS process, regulation and monitoring as well as flora, fauna and town management issues. This report also recognises that the Olympic Dam mine has been subject to previous environmental assessments which resulted in the environmental regime currently in place for the existing operations.It is concluded that the risks to the biophysical, historical, cultural and social environments from the proposed Olympic dam expansion are acceptable provided the mine continues to operate under stringent environmental control

  10. Does expert opinion match the operational definition of the Lupus Low Disease Activity State (LLDAS)? A case-based construct validity study.

    Science.gov (United States)

    Golder, Vera; Huq, Molla; Franklyn, Kate; Calderone, Alicia; Lateef, Aisha; Lau, Chak Sing; Lee, Alfred Lok Hang; Navarra, Sandra Teresa V; Godfrey, Timothy; Oon, Shereen; Hoi, Alberta Yik Bun; Morand, Eric Francis; Nikpour, Mandana

    2017-06-01

    To evaluate the construct validity of the Lupus Low Disease Activity State (LLDAS), a treatment target in systemic lupus erythematosus (SLE). Fifty SLE case summaries based on real patients were prepared and assessed independently for meeting the operational definition of LLDAS. Fifty international rheumatologists with expertise in SLE, but with no prior involvement in the LLDAS project, responded to a survey in which they were asked to categorize the disease activity state of each case as remission, low, moderate, or high. Agreement between expert opinion and LLDAS was assessed using Cohen's kappa. Overall agreement between expert opinion and the operational definition of LLDAS was 77.96% (95% CI: 76.34-79.58%), with a Cohen's kappa of 0.57 (95% CI: 0.55-0.61). Of the cases (22 of 50) that fulfilled the operational definition of LLDAS, only 5.34% (59 of 22 × 50) of responses classified the cases as moderate/high activity. Of the cases that did not fulfill the operational definition of LLDAS (28 of 50), 35.14% (492 of 28 × 50) of responses classified the cases as remission/low activity. Common reasons for discordance were assignment to remission/low activity of cases with higher corticosteroid doses than defined in LLDAS (prednisolone ≤ 7.5mg) or with SLEDAI-2K >4 due to serological activity (high anti-dsDNA antibody and/or low complement). LLDAS has good construct validity with high overall agreement between the operational definition of LLDAS and expert opinion. Discordance of results suggests that the operational definition of LLDAS is more stringent than expert opinion at defining a low disease activity state. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Within-Subject Testing of the Signaled-Reinforcement Effect on Operant Responding as Measured by Response Rate and Resistance to Change

    Science.gov (United States)

    Reed, Phil; Doughty, Adam H.

    2005-01-01

    Response rates under random-interval schedules are lower when a brief (500 ms) signal accompanies reinforcement than when there is no signal. The present study examined this signaled-reinforcement effect and its relation to resistance to change. In Experiment 1, rats responded on a multiple random-interval 60-s random-interval 60-s schedule, with…

  12. The work of the Operational Safety Review Team (OSART)

    International Nuclear Information System (INIS)

    Hide, K.W.

    1996-01-01

    The Operational Safety Review Team (OSART) programme was set up by the IAEA in 1982 to assist Member States to enhance the operational safety of nuclear power plants. Each team is staffed by senior experts in the relevant fields. The review team discusses with plant staff the existing operational programmes for plant which may be under construction, being commissioned or already operating. Following a detailed examination of a safety programme, the OSART team lists strengths and weaknesses and makes recommendations on how to overcome the latter. Since their conclusions are based on the best prevailing international practice, they may be more stringent than those based on national criteria. The results of the 77 missions conducted at 62 plants in 28 countries by the end of 1994 are summarised. (UK)

  13. Thermally assisted mechanical dewatering (TAMD) of suspensions of fine particles: analysis of the influence of the operating conditions using the response surface methodology.

    Science.gov (United States)

    Mahmoud, Akrama; Fernandez, Aurora; Chituchi, Toma-Mihai; Arlabosse, Patricia

    2008-08-01

    Thermally assisted mechanical dewatering (TAMD) is a new process for energy-efficient liquid/solids separation which enhances conventional-device efficiency. The main idea of this process is to supply a flow of heat in mechanical dewatering processes to favour the reduction of the liquid content. This is not a new idea but the proposed combination, especially the chosen operating conditions (temperature bentonite sludge provided by Soletanche Bachy Company. Experiment showed that the extent of TAMD for a given material is particularly dependent on their physical and chemical properties but also on processing parameters.

  14. 40 CFR 281.37 - Financial responsibility for UST systems containing petroleum.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Financial responsibility for UST systems containing petroleum. 281.37 Section 281.37 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVAL OF STATE UNDERGROUND STORAGE TANK PROGRAMS Criteria for No-Less-Stringent § 281.37 Financial...

  15. Advanced Neutron Source operating philosophy

    International Nuclear Information System (INIS)

    Houser, M.M.

    1993-01-01

    An operating philosophy and operations cost estimate were prepared to support the Conceptual Design Report for the Advanced Neutron Source (ANS), a new research reactor planned for the Oak Ridge National Laboratory (ORNL). The operating philosophy was part of the initial effort of the ANS Human Factors Program, was integrated into the conceptual design, and addressed operational issues such as remote vs local operation; control room layout and responsibility issues; role of the operator; simulation and training; staffing levels; and plant computer systems. This paper will report on the overall plans and purpose for the operations work, the results of the work done for conceptual design, and plans for future effort

  16. Investigation of the influence of FDM operating parameters on dynamic force response using IV-optimal design and principal component analysis

    Science.gov (United States)

    Mohamed, Omar Ahmed; Masood, Syed Hasan; Bhowmik, Jahar Lal

    2017-07-01

    To improve the functionality in regards to manufacturing products at low cost, several innovative additive manufacturing processes have been developed. Fused deposition modeling (FDM) is one the most prominent additive manufacturing processes for producing plastic products. Referring to the quality and functionality, there are many FDM process conditions contributing to the occurrence of poor quality and functionality of FDM manufactured products. Therefore, the effect of the build parameters on the functionality of FDM produced products need to be examined. In this study, an attempt has also been made to investigate the critical processing parameters affecting dynamic mechanical response of plastic part processed by FDM technology using IV-optimal response surface method coupled with principal component analysis technique. The results obtained from this study can be used in the future as a guide for future in selecting the appropriate process conditions before the manufacturing process of the product take place.

  17. Social Network Collaboration for Crisis Response Operations: Developing a Situational Awareness (SA) Tool to Improve Haiti’s Interagency Relief Efforts

    Science.gov (United States)

    2011-06-01

    CLA Collaborative Learning Agent DISE Distributed Information Systems Experimentation DoD Department of Defense HTML HyperText Markup...conducted in Haiti since the beginning of 2010 have been a growing concern for military, civil , and government leaders. The overarching objective is to...nongovernmental and civil organizations that provided support to the Haiti relief effort. The United States focused its response through the Interim Haiti

  18. Spacecraft operations

    CERN Document Server

    Sellmaier, Florian; Schmidhuber, Michael

    2015-01-01

    The book describes the basic concepts of spaceflight operations, for both, human and unmanned missions. The basic subsystems of a space vehicle are explained in dedicated chapters, the relationship of spacecraft design and the very unique space environment are laid out. Flight dynamics are taught as well as ground segment requirements. Mission operations are divided into preparation including management aspects, execution and planning. Deep space missions and space robotic operations are included as special cases. The book is based on a course held at the German Space Operation Center (GSOC).

  19. Operant Variability: Some Random Thoughts

    Science.gov (United States)

    Marr, M. Jackson

    2012-01-01

    Barba's (2012) paper is a serious and thoughtful analysis of a vexing problem in behavior analysis: Just what should count as an operant class and how do people know? The slippery issue of a "generalized operant" or functional response class illustrates one aspect of this problem, and "variation" or "novelty" as an operant appears to fall into…

  20. Operant Variability: Procedures and Processes

    Science.gov (United States)

    Machado, Armando; Tonneau, Francois

    2012-01-01

    Barba's (2012) article deftly weaves three main themes in one argument about operant variability. From general theoretical considerations on operant behavior (Catania, 1973), Barba derives methodological guidelines about response differentiation and applies them to the study of operant variability. In the process, he uncovers unnoticed features of…

  1. Accelerator operations

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    Operations of the SuperHILAC, the Bevatron/Bevalac, and the 184-inch Synchrocyclotron during the period from October 1977 to September 1978 are discussed. These include ion source development, accelerator facilities, the Heavy Ion Spectrometer System, and Bevelac biomedical operations

  2. Operational Sequencing

    DEFF Research Database (Denmark)

    Nielsen, Thomas Rosendal; Hustvedt, Kjersti

    2017-01-01

    by Bakhtinian theory, Brian Edmiston developed a solution to this in the 1990s: the principle of ‘dialogic sequencing’. Aiming to escape the conflict between relativism and absolutism, we present an alternative to Edmiston’s approach, based on Niklas Luhmann’s theory of ‘operational closure’: operational...

  3. Operating Systems

    Indian Academy of Sciences (India)

    M Suresh Babu is currently a fourth year undergraduate student in the Department of. Computer Science and. Engineering, Narayana. Engineering College,. Nellore, Andhra Pradesh. He would like to work in operating systems, computer networks and also in Internet security concepts. Keywords. Operating systems, file sys-.

  4. Operational Resilience

    Science.gov (United States)

    2014-10-16

    the so-called Threat Image Pro 51 April 2014 Operational Stress on Internet and eCommerce THE WALL STREET JOURNAL. TECH TECHNOLOGY Massive OpenSSL...8217!;:;a.L~ and · ...... -n ... ,.,. ... ,. 53 September 24, 2014 Operational Stress on Internet and eCommerce ::;:\\\\ t?nQCldQt?~ . REVIEWS

  5. Operation amplifier

    NARCIS (Netherlands)

    Tetsuya, Saito; Nauta, Bram

    2008-01-01

    To provide an operation amplifier which improves power source voltage removal ratios while assuring phase compensation characteristics, and therefore can be realized with a small-scale circuit and low power consumption. SOLUTION: The operation amplifier comprises: a differential amplifier circuit 1;

  6. Operation Amplifier

    NARCIS (Netherlands)

    Tetsuya, Saito; Nauta, Bram

    2011-01-01

    PROBLEM TO BE SOLVED: To provide an operation amplifier which improves power source voltage removal ratios while assuring phase compensation characteristics, and therefore can be realized with a small-scale circuit and low power consumption. SOLUTION: The operation amplifier comprises: a

  7. Operation Amplifier

    NARCIS (Netherlands)

    Tetsuya, S.; Nauta, Bram

    2007-01-01

    PROBLEM TO BE SOLVED: To provide an operation amplifier which improves power source voltage removal ratios while assuring phase compensation characteristics, and therefore can be realized with a small-scale circuit and low power consumption. ; SOLUTION: The operation amplifier comprises: a

  8. Use of computer aids including expert systems to enhance diagnosis of NPP safety status and operator response. VDU displays in accidents - Interact

    International Nuclear Information System (INIS)

    Humble, P.; Welbourne, D.

    1998-01-01

    This report describes NNC development of a demonstration concept called Interact of Visual Display Unit (VDU) displays, integrating on-screen control of plant actions. Most plant vendors now propose on-screen control and it is being included on some plants. The integration of Station Operating Instructions (SOI) into VDU presentation of plants is being developed rapidly. With on-screen control, SOIs can be displayed with control targets able to initiate plant control, directly as called for in the SOIs. Interact displays information and control options, using a cursor to simulate on-screen display and plant control. The displays show a method which integrates soft control and SOI information into a single unified presentation. They simulate the SOI for an accident, on-screen, with simulated inserted plant values

  9. Perceived Risk and Response to the Wind Turbine Ice Throw Hazard: Comparing Community Stakeholders and Operations and Maintenance Personnel in Two Regions of Texas

    Science.gov (United States)

    Klaus, Greg

    Risk managers who work directly with wind energy know that accumulations of ice on wind turbine blades pose a substantial risk to wind farm employees and a lesser extent to the general public. However, overall, the hazards of ice throw are not generally known to the public, as there has not been a significant event in the U.S. which has drawn any media attention. As we continue to install more and more turbines, the number of people exposed greatly increases, and it is only a matter of time before the industry suffers a severe incident or even a fatality. Thus, the goals of this research were threefold: 1) to understand the extent to which two at-risk groups--community stakeholders as well as operations and maintenance personnel at wind farms might differ in their perceived levels of risk to the ice throw hazard; 2) to understand the degree to which community stakeholders and operations and maintenance might differ on choosing measures of protection for their affected areas; and 3) to improve safety by identifying protective measures that all stakeholders--community citizens, wind farm employees, contractors, and land owners--are willing to undertake to mitigate their risk against the ice throw hazard which includes adopting measures to reduce their own risk toward the hazard, as well as, their community's vulnerability toward the hazards and threat of ice throw from wind turbines. This research also makes a valuable contribution to the theoretical body of risk research with respect to a technological hazard for which little is known. This research found that the two groups differed on statistically significant variables for observed risk, perceived personal risk, risk to the community, levels of trust in safety leaders, best protective actions, and preferred warning systems; however, there was no statistical significance between the groups on perceived benefits of wind energy.

  10. Hanaro operation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ji Bok; Jeon, Byung Jin; Kwack, Byung Ho [and others

    1997-01-01

    HANARO was configurated its first operating core in 1995. Long term operation test was conducted up to 3-1 cycle during 1996, in order to investigate the reactor characteristics due to fuel depletion and additional fuel loading. Now HANARO has accumulated 168.4 days of total operation time and 2,687.5 MWD of total thermal output. Reactor analysis, producing operation datum and its validation with test, periodic inspection and maintenance of the facility are continuously conducted for safe operation of the HANARO. Conducted the verification tests for installed utilization facilities, and successfully performed the radiation emergency drill. The shutdown report of TRIGA Mark II and III was submitted to MOST, and decommissioning will be started from 1997. (author). 70 tabs., 50 figs., 27 refs.

  11. A citizens' jury on regulation of McDonald's products and operations in Australia in response to a corporate health impact assessment.

    Science.gov (United States)

    Anaf, Julia; Baum, Fran; Fisher, Matthew

    2018-01-31

    1) To report outcomes from a citizens' jury examining regulatory responses to the health impacts of McDonald's Australia; 2) To determine the value of using citizens' juries to develop policy recommendations based on the findings of health impact assessment of transnational corporations (TNCs). A citizens' jury engaged 15 randomly selected and demographically representative jurors from metropolitan Adelaide to deliberate on the findings of a Corporate Health Impact Assessment, and to decide on appropriate policy actions. Jurors unanimously called for government regulation to ensure that transnational fast food corporations pay taxes on profits in the country of income. A majority (two-thirds) also recommended government regulation to reduce fast food advertising, and improve standards of consumer information including a star-ratings system. A minority held the view that no further regulation is required of the corporate fast food industry in Australia. The jury's recommendations can help inform policy makers about the importance of ending the legal profit-shifting strategies by TNCs that affect taxation revenue. They also endorse regulating the fast food industry to provide healthier food, and employing forms of community education and awareness-raising. Implications for public health: Citizens' juries can play an important role in providing feedback and policy recommendations in response to the findings of a health impact assessment of transnational corporations. © 2018 The Authors.

  12. FRMAC Operations Manual

    Energy Technology Data Exchange (ETDEWEB)

    Frandsen, K.

    2010-05-01

    In the event of a major radiological incident, the Federal Radiological Monitoring and Assessment Center (FRMAC) will coordinate the federal agencies that have various statutory responsibilities. The FRMAC is responsible for coordinating all environmental radiological monitoring, sampling, and assessment activities for the response. This manual describes the FRMAC’s response activities in a radiological incident. It also outlines how FRMAC fits in the National Incident Management System (NIMS) under the National Response Framework (NRF) and describes the federal assets and subsequent operational activities which provide federal radiological monitoring and assessment of the affected areas. In the event of a potential or existing major radiological incident, the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) is responsible for establishing and managing the FRMAC during the initial phases.

  13. Response of currents and water quality to changes in dam operations in Hoover Reservoir, Columbus, Ohio, August 24–28, 2015

    Science.gov (United States)

    Vonins, Branden L.; Jackson, P. Ryan

    2017-05-25

    Hoover Reservoir, an important drinking water supply for the City of Columbus, Ohio, has been the source of a series of taste and odor problems in treated drinking water during the past few years. These taste and odor problems were caused by the compounds geosmin and 2-methylisoborneol, which are thought to have been related to cyanobacteria blooms. In an effort to reduce the phosphorus available for cyanobacteria blooms at fall turnover, the City of Columbus began experimenting with the dam’s selective withdrawal system to remove excess phosphorus in the hypolimnion, which is released from bottom sediments during summer anoxic conditions.The U.S. Geological Survey completed two synoptic survey campaigns to assess distributions of water quality and water velocity in the lower part of Hoover Reservoir to provide information on the changes to reservoir dynamics caused by changing dam operations. One campaign (campaign 1) was done while water was being withdrawn from the reservoir through the dam’s middle gate and the other (campaign 2) while water was being withdrawn through the dam’s lower gate. Velocities were measured using an acoustic Doppler current profiler, and water-quality parameters were measured using an autonomous underwater vehicle equipped with water-quality sensors. Along with the water-quality and water-velocity data, meteorological, inflow and outflow discharges, and independent water-quality data were compiled to monitor changes in other parameters that affect reservoir behavior. Monthly nutrient data, collected by the City of Columbus, were also analyzed for trends in concentration during periods of expected stratification.Based on the results of the two campaigns, when compared to withdrawing water through the middle gate, withdrawing water through the lower gate seemed to increase shear-driven mixing across the thermocline, which resulted in an increase in the depth of the epilimnion throughout the lower part of Hoover Reservoir. The

  14. Operator lattices

    International Nuclear Information System (INIS)

    Bender, C.M.

    1984-01-01

    The finite-element method enables us to convert the operator differential equations of a quantum field theory into operator difference equations. These difference equations are consistent with the requirements of quantum mechanics and they do not exhibit fermion doubling, a problem that frequently plagues lattice treatments of fermions. Guage invariance can also be incorporated into the difference equations. On a finite lattice the operator difference equations can be solved in closed form. For the case of the Schwinger model the anomaly is computed and results in excellent agreement are obtained with the known continuum value

  15. Reactor operation

    CERN Document Server

    Shaw, J

    2013-01-01

    Reactor Operation covers the theoretical aspects and design information of nuclear reactors. This book is composed of nine chapters that also consider their control, calibration, and experimentation.The opening chapters present the general problems of reactor operation and the principles of reactor control and operation. The succeeding chapters deal with the instrumentation, start-up, pre-commissioning, and physical experiments of nuclear reactors. The remaining chapters are devoted to the control rod calibrations and temperature coefficient measurements in the reactor. These chapters also exp

  16. Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses

    Directory of Open Access Journals (Sweden)

    Sorribas Albert

    2009-11-01

    Full Text Available Abstract Background Optimization methods allow designing changes in a system so that specific goals are attained. These techniques are fundamental for metabolic engineering. However, they are not directly applicable for investigating the evolution of metabolic adaptation to environmental changes. Although biological systems have evolved by natural selection and result in well-adapted systems, we can hardly expect that actual metabolic processes are at the theoretical optimum that could result from an optimization analysis. More likely, natural systems are to be found in a feasible region compatible with global physiological requirements. Results We first present a new method for globally optimizing nonlinear models of metabolic pathways that are based on the Generalized Mass Action (GMA representation. The optimization task is posed as a nonconvex nonlinear programming (NLP problem that is solved by an outer-approximation algorithm. This method relies on solving iteratively reduced NLP slave subproblems and mixed-integer linear programming (MILP master problems that provide valid upper and lower bounds, respectively, on the global solution to the original NLP. The capabilities of this method are illustrated through its application to the anaerobic fermentation pathway in Saccharomyces cerevisiae. We next introduce a method to identify the feasibility parametric regions that allow a system to meet a set of physiological constraints that can be represented in mathematical terms through algebraic equations. This technique is based on applying the outer-approximation based algorithm iteratively over a reduced search space in order to identify regions that contain feasible solutions to the problem and discard others in which no feasible solution exists. As an example, we characterize the feasible enzyme activity changes that are compatible with an appropriate adaptive response of yeast Saccharomyces cerevisiae to heat shock Conclusion Our results

  17. Response probability and response time: a straight line, the Tagging/Retagging interpretation of short term memory, an operational definition of meaningfulness and short term memory time decay and search time.

    Science.gov (United States)

    Tarnow, Eugen

    2008-12-01

    The functional relationship between correct response probability and response time is investigated in data sets from Rubin, Hinton and Wenzel, J Exp Psychol Learn Mem Cogn 25:1161-1176, 1999 and Anderson, J Exp Psychol [Hum Learn] 7:326-343, 1981. The two measures are linearly related through stimulus presentation lags from 0 to 594 s in the former experiment and for repeated learning of words in the latter. The Tagging/Retagging interpretation of short term memory is introduced to explain this linear relationship. At stimulus presentation the words are tagged. This tagging level drops slowly with time. When a probe word is reintroduced the tagging level has to increase for the word to be properly identified leading to a delay in response time. The tagging time is related to the meaningfulness of the words used-the more meaningful the word the longer the tagging time. After stimulus presentation the tagging level drops in a logarithmic fashion to 50% after 10 s and to 20% after 240 s. The incorrect recall and recognition times saturate in the Rubin et al. data set (they are not linear for large time lags), suggesting a limited time to search the short term memory structure: the search time for recall of unusual words is 1.7 s. For recognition of nonsense words the corresponding time is about 0.4 s, similar to the 0.243 s found in Cavanagh (1972).

  18. Operational Research

    CERN Document Server

    Almeida, João; Oliveira, José; Pinto, Alberto

    2018-01-01

    This proceedings book presents selected contributions from the XVIII Congress of APDIO (the Portuguese Association of Operational Research) held in Valença on June 28–30, 2017. Prepared by leading Portuguese and international researchers in the field of operations research, it covers a wide range of complex real-world applications of operations research methods using recent theoretical techniques, in order to narrow the gap between academic research and practical applications. Of particular interest are the applications of, nonlinear and mixed-integer programming, data envelopment analysis, clustering techniques, hybrid heuristics, supply chain management, and lot sizing and job scheduling problems. In most chapters, the problems, methods and methodologies described are complemented by supporting figures, tables and algorithms.   The XVIII Congress of APDIO marked the 18th installment of the regular biannual meetings of APDIO – the Portuguese Association of Operational Research. The meetings bring toget...

  19. Operator training

    International Nuclear Information System (INIS)

    Wirstad, J.

    1983-12-01

    The traditional operator job is changing, which among other things has generated a need for better job training. Surprisingly increased process automation has lead to increased operator qualifications, i.e. basic job training but also up-date and rehearsal training within certain fixed intervals. There are several, similar models for instructional system development available in the literature. One model which is of special interest integrates Operator Training development and Man-Machine Interfaces development. The extent to which Systematic Operator Training has been implemented varies with branches and companies. The nuclear power branch is given as an example in the report. This branch probably represents something better than the average among the process industries.(author)

  20. Peace Operations

    National Research Council Canada - National Science Library

    Proks, Josef

    2000-01-01

    Peace operations are more and more important in the contemporary world. The end of the Cold War increased not only possibilities of solving disputes by the international community but also by the number and diversity of threats and issues...

  1. Operator theory

    CERN Document Server

    2015-01-01

    A one-sentence definition of operator theory could be: The study of (linear) continuous operations between topological vector spaces, these being in general (but not exclusively) Fréchet, Banach, or Hilbert spaces (or their duals). Operator theory is thus a very wide field, with numerous facets, both applied and theoretical. There are deep connections with complex analysis, functional analysis, mathematical physics, and electrical engineering, to name a few. Fascinating new applications and directions regularly appear, such as operator spaces, free probability, and applications to Clifford analysis. In our choice of the sections, we tried to reflect this diversity. This is a dynamic ongoing project, and more sections are planned, to complete the picture. We hope you enjoy the reading, and profit from this endeavor.

  2. Operant Conditioning - Token Economy.

    Science.gov (United States)

    Montgomery, Jacqueline; McBurney, Raymond D.

    Described is an Operant Conditioning-Token Economy Program, teaching patients to be responsible for their own behavior, to make choices, and to be motivated to change. The program was instigated with mentally ill patients in a state hospital and was later used with institutionalized mentally handicapped groups. After two years, only four of the…

  3. The use of volunteer interpreters during the 201 0 Haiti earthquake: lessons learned from the USNS COMFORT Operation Unified Response Haiti.

    Science.gov (United States)

    Powell, Clydette; Pagliara-Miller, Claire

    2012-01-01

    On January 12, 2010, a 7.0 magnitude Richter earthquake devastated Haiti, leading to the world's largest humanitarian effort in 60 years. The catastrophe led to massive destruction of homes and buildings, the loss of more than 200,000 lives, and overwhelmed the host nation response and its public health infrastructure. Among the many responders, the United States Government acted immediately by sending assistance to Haiti including a naval hospital ship as a tertiary care medical center, the USNS COMFORT. To adequately respond to the acute needs of patients, healthcare professionals on the USNS COMFORT relied on Haitian Creole-speaking volunteers who were recruited by the American Red Cross (ARC). These volunteers complemented full-time Creole-speaking military staff on board. The ARC provided 78 volunteers who were each able to serve up to 4 weeks on board. Volunteers' demographics, such as age and gender, as well as linguistic skills, work background, and prior humanitarian assistance experience varied. Volunteer efforts were critical in assisting with informed consent for surgery, family reunification processes, explanation of diagnosis and treatment, comfort to patients and families in various stages of grieving and death, and helping healthcare professionals to understand the cultural context and sensitivities unique to Haiti. This article explores key lessons learned in the use of volunteer interpreters in earthquake disaster relief in Haiti and highlights the approaches that optimize volunteer services in such a setting, and which may be applicable in similar future events.

  4. Operant Variability and Voluntary Action

    Science.gov (United States)

    Neuringer, Allen; Jensen, Greg

    2010-01-01

    A behavior-based theory identified 2 characteristics of voluntary acts. The first, extensively explored in operant-conditioning experiments, is that voluntary responses produce the reinforcers that control them. This bidirectional relationship--in which reinforcer depends on response and response on reinforcer--demonstrates the functional nature…

  5. The analysis of the differences between the results of the thermal response test and the data from the operation of the brine-to-water heat pump’s vertical exchanger

    Directory of Open Access Journals (Sweden)

    Fidorów-Kaprawy Natalia

    2017-01-01

    Full Text Available The article discusses the principles and the problems of obtaining an accurate data input for the design of brine-to-water heat pump’s vertical exchangers. Currently, the most accurate method is the thermal response test (TRT. Unfortunately, the test procedure has its limitations and the quality of the results depends on many factors that cannot be fully controlled during the test. As an illustration of the problems, the results of the TRT were presented. The test was executed on the vertical boreholes (one actively regenerated and one not actively regenerated during the summer which are parts of the operating heat pump system. The test results were compared to the data from the device’s operation, in particular with the measurements of the undisturbed ground temperature profiles and the actual unit energy gains from the boreholes. The level of difference between the results of the test and the data from the operation of the boreholes under the real load and the threats concerning the boreholes overload were shown. Additionally the performance differences between the actively regenerated and not actively regenerated boreholes have been emphasised.

  6. Impact of neoadjuvant single or dual HER2 inhibition and chemotherapy backbone upon pathological complete response in operable and locally advanced breast cancer: Sensitivity analysis of randomized trials.

    Science.gov (United States)

    Bria, Emilio; Carbognin, Luisa; Furlanetto, Jenny; Pilotto, Sara; Bonomi, Maria; Guarneri, Valentina; Vicentini, Cecilia; Brunelli, Matteo; Nortilli, Rolando; Pellini, Francesca; Sperduti, Isabella; Giannarelli, Diana; Pollini, Giovanni Paolo; Conte, Pierfranco; Tortora, Giampaolo

    2014-08-01

    The role of the dual HER2 inhibition, and the best chemotherapy backbone for neoadjuvant chemotherapy still represent an issue for clinical practice. A literature-based meta-analysis exploring single versus dual HER2 inhibition in terms of pathological complete response (pCR, breast plus axilla) rate and testing the interaction according to the chemotherapy (anthracyclines-taxanes or taxanes) was conducted. In addition, an event-based pooled analysis by extracting activity and safety events and deriving 95% confidence intervals (CI) was accomplished. Fourteen trials (4149 patients) were identified, with 6 trials (1820 patients) included in the meta-analysis and 31 arms (14 trials, 3580 patients) in the event-based pooled analysis. The dual HER2 inhibition significantly improves pCR rate, in the range of 16-19%, regardless of the chemotherapy backbone (relative risk 1.37, 95% CI 1.23-1.53, p<0.0001); pCR was significantly higher in the hormonal receptor negative population, regardless of the HER2 inhibition and type of chemotherapy. pCR and the rate of breast conserving surgery was higher when anthracyclines were added to taxanes, regardless of the HER2 inhibition. Severe neutropenia was higher with the addition of anthracyclines to taxanes, with an absolute difference of 19.7%, despite no differences in febrile neutropenia. While no significant differences according to the HER2 inhibition were found in terms of cardiotoxicity, a slightly difference for grade 3-4 (1.2%) against the addition of anthracyclines was calculated. The dual HER2 inhibition for the neoadjuvant treatment of HER2-positive breast cancer significantly increases pCR; the combination of anthracyclines, taxanes and anti-Her2 agents should be currently considered the standard of care. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Applied Operations Research: Operator's Assistant

    Science.gov (United States)

    Cole, Stuart K.

    2015-01-01

    NASA operates high value critical equipment (HVCE) that requires trouble shooting, periodic maintenance and continued monitoring by Operations staff. The complexity HVCE and information required to maintain and trouble shoot HVCE to assure continued mission success as paper is voluminous. Training on new HVCE is commensurate with the need for equipment maintenance. LaRC Research Directorate has undertaken a proactive research to support Operations staff by initiation of the development and prototyping an electronic computer based portable maintenance aid (Operator's Assistant). This research established a goal with multiple objectives and a working prototype was developed. The research identified affordable solutions; constraints; demonstrated use of commercial off the shelf software; use of the US Coast Guard maintenance solution; NASA Procedure Representation Language; and the identification of computer system strategies; where these demonstrations and capabilities support the Operator, and maintenance. The results revealed validation against measures of effectiveness and overall proved a substantial training and capability sustainment tool. The research indicated that the OA could be deployed operationally at the LaRC Compressor Station with an expectation of satisfactorily results and to obtain additional lessons learned prior to deployment at other LaRC Research Directorate Facilities. The research revealed projected cost and time savings.

  8. Operator companion

    International Nuclear Information System (INIS)

    Natalizio, A.; Anderson, J.W.D.; Sills, H.E.

    1988-01-01

    Abundant, cheap computing power has provided industry with a far greater opportunity than was available one or two decades ago to automate industrial processes and to improve the man-machine interface. Exciting innovations in knowledge representation methods arising from artificial intelligence research pave the way for advanced support systems for assisting plant operators. AECL has recognized the importance of knowledge based system technology, particularly expert systems, in the achievement of this objective and also, as a strategic technology to be fully exploited in the next generation of CANDU reactors. Operator Companion, an expert system intended to diagnose plant faults and advise the operator on appropriate restoring or corrective actions, is a major undertaking which is receiving support within the research and engineering groups of AECL

  9. Nuclear material operations manual

    International Nuclear Information System (INIS)

    Tyler, R.P.

    1981-02-01

    This manual provides a concise and comprehensive documentation of the operating procedures currently practiced at Sandia National Laboratories with regard to the management, control, and accountability of nuclear materials. The manual is divided into chapters which are devoted to the separate functions performed in nuclear material operations-management, control, accountability, and safeguards, and the final two chapters comprise a document which is also issued separately to provide a summary of the information and operating procedures relevant to custodians and users of radioactive and nuclear materials. The manual also contains samples of the forms utilized in carrying out nuclear material activities. To enhance the clarity of presentation, operating procedures are presented in the form of playscripts in which the responsible organizations and necessary actions are clearly delineated in a chronological fashion from the initiation of a transaction to its completion

  10. Nuclear material operations manuals

    International Nuclear Information System (INIS)

    Tyler, R.P.

    1979-06-01

    This manual is intended to provide a concise and comprehensive documentation of the operating procedures currently practiced at Sandia Laboratories with regard to the management, control, and accountability of radioactive and nuclear materials. The manual is divided into chapters which are devoted to the separate functions performed in nuclear material operations-management, control, accountability, and safeguards, and the final two chapters comprise a document which is also issued separately to provide a summary of the information and operating procedures relevant to custodians and users of radioactive and nuclear materials. The manual also contains samples of the forms utilized in carrying out nuclear material activities. To enhance the clarity of presentation, operating procedures are presented in the form of playscripts in which the responsible organizations and necessary actions are clearly delineated in a chronological fashion from the initiation of a transaction to its completion

  11. Nuclear material operations manual

    Energy Technology Data Exchange (ETDEWEB)

    Tyler, R.P.

    1981-02-01

    This manual provides a concise and comprehensive documentation of the operating procedures currently practiced at Sandia National Laboratories with regard to the management, control, and accountability of nuclear materials. The manual is divided into chapters which are devoted to the separate functions performed in nuclear material operations-management, control, accountability, and safeguards, and the final two chapters comprise a document which is also issued separately to provide a summary of the information and operating procedures relevant to custodians and users of radioactive and nuclear materials. The manual also contains samples of the forms utilized in carrying out nuclear material activities. To enhance the clarity of presentation, operating procedures are presented in the form of playscripts in which the responsible organizations and necessary actions are clearly delineated in a chronological fashion from the initiation of a transaction to its completion.

  12. A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Stress Disorder.

    Science.gov (United States)

    Bremner, James Douglas; Mishra, Sanskriti; Campanella, Carolina; Shah, Majid; Kasher, Nicole; Evans, Sarah; Fani, Negar; Shah, Amit Jasvant; Reiff, Collin; Davis, Lori L; Vaccarino, Viola; Carmody, James

    2017-01-01

    Brain imaging studies in patients with post-traumatic stress disorder (PTSD) have implicated a circuitry of brain regions including the medial prefrontal cortex, amygdala, hippocampus, parietal cortex, and insula. Pharmacological treatment studies have shown a reversal of medial prefrontal deficits in response to traumatic reminders. Mindfulness-based stress reduction (MBSR) is a promising non-pharmacologic approach to the treatment of anxiety and pain disorders. The purpose of this study was to assess the effects of MBSR on PTSD symptoms and brain response to traumatic reminders measured with positron-emission tomography (PET) in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) combat veterans with PTSD. We hypothesized that MBSR would show increased prefrontal response to stress and improved PTSD symptoms in veterans with PTSD. Twenty-six OEF/OIF combat veterans with PTSD who had recently returned from a combat zone were block randomized to receive eight sessions of MBSR or present-centered group therapy (PCGT). PTSD patients underwent assessment of PTSD symptoms with the Clinician-Administered PTSD Scale (CAPS), mindfulness with the Five Factor Mindfulness Questionnaire (FFMQ) and brain imaging using PET in conjunction with exposure to neutral and Iraq combat-related slides and sound before and after treatment. Nine patients in the MBSR group and 8 in the PCGT group completed all study procedures. Post-traumatic stress disorder patients treated with MBSR (but not PCGT) had an improvement in PTSD symptoms measured with the CAPS that persisted for 6 months after treatment. MBSR also resulted in an increase in mindfulness measured with the FFMQ. MBSR-treated patients had increased anterior cingulate and inferior parietal lobule and decreased insula and precuneus function in response to traumatic reminders compared to the PCGT group. This study shows that MBSR is a safe and effective treatment for PTSD. Furthermore, MBSR treatment is associated with

  13. A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Stress Disorder

    Directory of Open Access Journals (Sweden)

    James Douglas Bremner

    2017-08-01

    Full Text Available ObjectiveBrain imaging studies in patients with post-traumatic stress disorder (PTSD have implicated a circuitry of brain regions including the medial prefrontal cortex, amygdala, hippocampus, parietal cortex, and insula. Pharmacological treatment studies have shown a reversal of medial prefrontal deficits in response to traumatic reminders. Mindfulness-based stress reduction (MBSR is a promising non-pharmacologic approach to the treatment of anxiety and pain disorders. The purpose of this study was to assess the effects of MBSR on PTSD symptoms and brain response to traumatic reminders measured with positron-emission tomography (PET in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF combat veterans with PTSD. We hypothesized that MBSR would show increased prefrontal response to stress and improved PTSD symptoms in veterans with PTSD.MethodTwenty-six OEF/OIF combat veterans with PTSD who had recently returned from a combat zone were block randomized to receive eight sessions of MBSR or present-centered group therapy (PCGT. PTSD patients underwent assessment of PTSD symptoms with the Clinician-Administered PTSD Scale (CAPS, mindfulness with the Five Factor Mindfulness Questionnaire (FFMQ and brain imaging using PET in conjunction with exposure to neutral and Iraq combat-related slides and sound before and after treatment. Nine patients in the MBSR group and 8 in the PCGT group completed all study procedures.ResultsPost-traumatic stress disorder patients treated with MBSR (but not PCGT had an improvement in PTSD symptoms measured with the CAPS that persisted for 6 months after treatment. MBSR also resulted in an increase in mindfulness measured with the FFMQ. MBSR-treated patients had increased anterior cingulate and inferior parietal lobule and decreased insula and precuneus function in response to traumatic reminders compared to the PCGT group.ConclusionThis study shows that MBSR is a safe and effective treatment for PTSD

  14. Operational indicators

    International Nuclear Information System (INIS)

    2010-01-01

    The chapter presents the operational indicators related to budget, travel costs and tickets, the evolution of the annual program for regulatory inspection, the scientific production, requested patents and the numbers related to the production of the services offered by the Institution

  15. Operating Systems

    Indian Academy of Sciences (India)

    areas in which this type is useful are multimedia, virtual reality, and advanced scientific projects such as undersea exploration and planetary rovers. Because of the expanded uses for soft real-time functionality, it is finding its way into most current operating systems, including major versions of Unix and Windows NT OS.

  16. Peace Operations

    National Research Council Canada - National Science Library

    Lewis, William

    1995-01-01

    .... Indeed, despite the energetic leadership of Under Secretary-General Kofi R. Annan who directs the Department of Peacekeeping Operations, the organization has increasing difficulty in acquiring properly trained and equipped forces in time to intervene in conflict situations and humanitarian crises.

  17. Accelerator operations

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    This section is concerned with the operation of both the tandem-linac system and the Dynamitron, two accelerators that are used for entirely different research. Developmental activities associated with the tandem and the Dynamitron are also treated here, but developmental activities associated with the superconducting linac are covered separately because this work is a program of technology development in its own right

  18. Operation Context

    DEFF Research Database (Denmark)

    Stüben, Henning; Tietjen, Anne

    2006-01-01

    Abstract: This paper seeks to challenge the notion of context from an operational perspective. Can we grasp the forces that shape the complex conditions for an architectural or urban design within the notion of context? By shifting the gaze towards the agency of architecture, contextual analysis...

  19. Operational Circulars

    CERN Multimedia

    2003-01-01

    Operational Circular N° 4 - April 2003 Conditions for use by members of the CERN personnel of vehicles belonging to or rented by CERN - This circular has been drawn up. Operational Circular N° 5 - October 2000 Use of CERN computing facilities - Further details on the personal use of CERN computing facilities Operational Circular N° 5 and its Subsidiary Rules http://cern.ch/ComputingRules defines the rules for the use of CERN computing facilities. One of the basic principles governing such use is that it must come within the professional duties of the user concerned, as defined by the user's divisional hierarchy. However, personal use of the computing facilities is tolerated or allowed provided : a) It is in compliance with Operational Circular N° 5 and not detrimental to official duties, including those of other users; b) the frequency and duration is limited and there is a negligible use of CERN resources; c) it does not constitute a political, commercial and/or profit-making activity; d) it is not...

  20. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Surgeons Education Patients and Family Skills Programs Your Lung Operation Your Lung Operation DVD After Your Operation Back to Your Lung Operation Your Lung Operation DVD Welcome Your Lung ...

  1. Operating Cigeo

    International Nuclear Information System (INIS)

    Launeau, F.

    2016-01-01

    The CIGEO facility dedicated to the geological disposal of high- and intermediate-level radioactive wastes will be composed of 2 parts: an underground facility at a depth of 500 m to dispose the waste packages in tunnels and a surface facility to take delivery of the wastes and prepare the packages. The underground facility will be built progressively and will cover a surface of 15 km 2 at the end of Cigeo operating-life. A large part of the surface facility (located a few km away from the waste reception place) will be dedicated to the works led deep underground to build the tunnels and will receive drilling cuttings. The article describes also the ramp and carts to lead waste packages underground. Most of the operations will be automated. The definitive closure of the tunnels will be made with swelling clay and concrete plugs. (A.C.)

  2. Applicability Limits of Operational Modal Analysis to Operational Wind Turbines

    DEFF Research Database (Denmark)

    Tcherniak, D.; Chauhan, Shashank; Hansen, Morten Hartvig

    2011-01-01

    Operational Modal Analysis (OMA) is one of the branches of experimental modal analysis which allows extracting modal parameters based on measuring only the responses of a structure under ambient or operational excitation which is not needed to be measured. This makes OMA extremely attractive to m...... excitation and sets limitations on the applicability of OMA to operational wind turbines. The main purpose of the study is to warn the experimentalists about these limitations and discuss possible ways of dealing with them....

  3. Operative Links

    DEFF Research Database (Denmark)

    Wistoft, Karen; Højlund, Holger

    2012-01-01

    educational approaches. Methods: Mixed qualitative design: survey based on telephone interviews with health managers (n=72), personal and focus group interviews with health professionals (n=84) and pupils (n=108) from 18 school classes, and comparative case studies in five selected municipalities of various...... educational goals, learning content, or value clarification. Health pedagogy is often a matter of retrospective rationalization rather than the starting point of planning. Health and risk behaviour approaches override health educational approaches. Conclusions: Operational links between health education...

  4. Operation Poorman

    International Nuclear Information System (INIS)

    Pruvost, N.; Tsitouras, J.

    1981-01-01

    The objectives of Operation Poorman were to design and build a portable seismic system and to set up and use this system in a cold-weather environment. The equipment design uses current technology to achieve a low-power, lightweight system that is configured into three modules. The system was deployed in Alaska during wintertime, and the results provide a basis for specifying a mission-ready seismic verification system

  5. Intelligent decision-making models for production and retail operations

    CERN Document Server

    Guo, Zhaoxia

    2016-01-01

    This book provides an overview of intelligent decision-making techniques and discusses their application in production and retail operations. Manufacturing and retail enterprises have stringent standards for using advanced and reliable techniques to improve decision-making processes, since these processes have significant effects on the performance of relevant operations and the entire supply chain. In recent years, researchers have been increasingly focusing attention on using intelligent techniques to solve various decision-making problems. The opening chapters provide an introduction to several commonly used intelligent techniques, such as genetic algorithm, harmony search, neural network and extreme learning machine. The book then explores the use of these techniques for handling various production and retail decision-making problems, such as production planning and scheduling, assembly line balancing, and sales forecasting.

  6. Constitutive and Operational Variation of Learning in Foraging Predatory Mites.

    Science.gov (United States)

    Seiter, Michael; Schausberger, Peter

    2016-01-01

    Learning is widely documented across animal taxa but studies stringently scrutinizing the causes of constitutive or operational variation of learning among populations and individuals are scarce. The ability to learn is genetically determined and subject to constitutive variation while the performance in learning depends on the immediate circumstances and is subject to operational variation. We assessed variation in learning ability and performance of plant-inhabiting predatory mites, Amblyseius swirskii, caused by population origin, rearing diet, and type of experience. Using an early learning foraging paradigm, we determined that homogeneous single prey environments did not select for reduced learning ability, as compared to natural prey-diverse environments, whereas a multi-generational pollen diet resulted in loss of learning, as compared to a diet of live prey. Associative learning produced stronger effects than non-associative learning but both types of experience produced persistent memory. Our study represents a key example of environmentally caused variation in learning ability and performance.

  7. Constitutive and Operational Variation of Learning in Foraging Predatory Mites

    Science.gov (United States)

    Seiter, Michael

    2016-01-01

    Learning is widely documented across animal taxa but studies stringently scrutinizing the causes of constitutive or operational variation of learning among populations and individuals are scarce. The ability to learn is genetically determined and subject to constitutive variation while the performance in learning depends on the immediate circumstances and is subject to operational variation. We assessed variation in learning ability and performance of plant-inhabiting predatory mites, Amblyseius swirskii, caused by population origin, rearing diet, and type of experience. Using an early learning foraging paradigm, we determined that homogeneous single prey environments did not select for reduced learning ability, as compared to natural prey-diverse environments, whereas a multi-generational pollen diet resulted in loss of learning, as compared to a diet of live prey. Associative learning produced stronger effects than non-associative learning but both types of experience produced persistent memory. Our study represents a key example of environmentally caused variation in learning ability and performance. PMID:27814380

  8. Operationally Responsive Spacecraft Subsystem, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Saber Astronautics proposes spacecraft subsystem control software which can autonomously reconfigure avionics for best performance during various mission conditions....

  9. Operative links

    DEFF Research Database (Denmark)

    Wistoft, Karen

    2010-01-01

    and have been the object of great expectations concerning the ability to incorporate health concerns into every welfare area through health promotion strategies. The paper draws on results and analyses of a collective research project funded by the Danish National Research Council and carried out...... as networks: second, a semantic perspective on discourses and concepts of health, and, third, a health pedagogical perspective on participation, intervention, and roles. This paper argues for the importance of 'operative links' between different levels in health strategies. It is proposed that such links...

  10. Operations management for construction

    CERN Document Server

    March, Chris

    2009-01-01

    Students studying construction management and related subjects need to have a broad understanding of the major aspects of controlling the building processes. Operations Management for Construction is one of three textbooks (Business Organisation, Operations Management and Finance Control) written to systematically cover the field. Focusing on construction sites and operations which are challenging to run, Chris March explores issues such as the setting up of the site, the deciding of the methodology of construction, and the sequence of work and resourcing. As changing and increasing regulations affect the way sites are managed, he also considers the issues and methods of successful administering, safety, quality and environment. Finally, the contractor's responsibility to the environment, including relationships with third parties, selection of materials, waste management and sustainability is discussed. Chris March has a wealth of practical experience in the construction industry, as well as considerable exp...

  11. Simulators for NPP operators

    International Nuclear Information System (INIS)

    Yuzhakov, A.Yu.

    2010-01-01

    The author reports on the application of full-scale simulators for training and maintaining proficiency of unit control room operators that is an essential element of Russian NPPs personnel education system. The existing simulators for the unit control room operating personnel are listed. The integrated approach to developing and maintaining the training hardware is described. The integrated approach is being implemented on the basis of observance of the existing requirements to training hardware, improvement of regulations, control from a single centre responsible for the provision of support to the activities, inclusion into the plans of simulators for development of skills for operating control over equipment and systems, as well as control from local boards [ru

  12. Operational limits and conditions and operating procedures for research reactors. Safety guide

    International Nuclear Information System (INIS)

    2008-01-01

    This publication provides practical guidance on all important aspects of developing, formulating and presenting the operational limits and conditions as well as the operating procedures for research reactors. It covers the concept of operational limits and conditions, their content, and the responsibilities of the operating organization with respect to their establishment, modification, documentation and compliance. The guidance also covers the training of operating personnel on performing periodic testing, established by the operational limits and conditions, and operating procedures

  13. Concept of Deployable Network Operations Center (DNOC)

    National Research Council Canada - National Science Library

    Bordetsky, Alex; Thiry, Jeff; Johnson, Shawn

    2005-01-01

    .... The increasing use of expeditionary and special operations forces in ad hoc, dynamic, and tactical environments poses a need for an adaptable, flexible, and responsive deployable network operations center (DNOC...

  14. A Multiprocessor Operating System Simulator

    Science.gov (United States)

    Johnston, Gary M.; Campbell, Roy H.

    1988-01-01

    This paper describes a multiprocessor operating system simulator that was developed by the authors in the Fall semester of 1987. The simulator was built in response to the need to provide students with an environment in which to build and test operating system concepts as part of the coursework of a third-year undergraduate operating systems course. Written in C++, the simulator uses the co-routine style task package that is distributed with the AT&T C++ Translator to provide a hierarchy of classes that represents a broad range of operating system software and hardware components. The class hierarchy closely follows that of the 'Choices' family of operating systems for loosely- and tightly-coupled multiprocessors. During an operating system course, these classes are refined and specialized by students in homework assignments to facilitate experimentation with different aspects of operating system design and policy decisions. The current implementation runs on the IBM RT PC under 4.3bsd UNIX.

  15. Operator errors

    International Nuclear Information System (INIS)

    Knuefer; Lindauer

    1980-01-01

    Besides that at spectacular events a combination of component failure and human error is often found. Especially the Rasmussen-Report and the German Risk Assessment Study show for pressurised water reactors that human error must not be underestimated. Although operator errors as a form of human error can never be eliminated entirely, they can be minimized and their effects kept within acceptable limits if a thorough training of personnel is combined with an adequate design of the plant against accidents. Contrary to the investigation of engineering errors, the investigation of human errors has so far been carried out with relatively small budgets. Intensified investigations in this field appear to be a worthwhile effort. (orig.)

  16. Operational safety of nuclear power plants

    International Nuclear Information System (INIS)

    Tanguy, P.

    1987-01-01

    The operational safety of nuclear power plants has become an important safety issue since the Chernobyl accident. A description is given of the various aspects of operational safety, including the importance of human factors, responsibility, the role and training of the operator, the operator-machine interface, commissioning and operating procedures, experience feedback, and maintenance. The lessons to be learnt from Chernobyl are considered with respect to operator errors and the management of severe accidents. Training of personnel, operating experience feedback, actions to be taken in case of severe accidents, and international cooperation in the field of operational safety, are also discussed. (U.K.)

  17. HOW DO HOSPITAL STERILISATION PROCEDURES AFFECT THE RESPONSE OF PERSONAL EXTREMITY RINGS AND OF EYE LENS TL DOSEMETERS?

    Science.gov (United States)

    Kopeć, Renata; Bubak, Anna; Budzanowski, Maciej; Sas-Bieniarz, Anna; Szumska, Agnieszka

    2016-09-01

    Stringent standards of hygiene must be applied in medical institutions, especially at operating blocks or during interventional radiology procedures. Medical equipment, including personal dosemeters that have to be worn by medical staff during such procedures, needs therefore to be sterilised. In this study, the effect of various sterilisation procedures has been tested on the dose response of extremity rings and of eye lens dosemeters in which thermoluminescent (TL) detectors (of types MTS-N and MCP-N, respectively) are used. The effects of medical sterilisation procedures were studied: by chemicals, by steam or by ultraviolet (UV), on the dose assessment by extremity rings and by eye lens dosemeters. Since it often happens that a dosemeter is accidentally machine-washed together with protective clothing, the effect of laundering on dose assessment by these dosemeters was also tested. The sterilisation by chemicals is mostly safe for TL detectors assuming that the dosemeters are waterproofed. Following sterilisation by water vapour, the response of these dosemeters diminished by some 30 %, irrespectively of the period of sterilisation; therefore, this method is not recommended. UV sterilisation can be applied to EYE-D™ eye lens dosemeters if their encapsulation is in black. The accidental dosemeter laundry in a washing machine has no impact on measured dose. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  18. Operational Stress Control and Readiness (OSCAR): The United States Marine Corps Initiative to Deliver Mental Health Services to Operating Forces

    National Research Council Canada - National Science Library

    Nash, William P

    2006-01-01

    Combat/operational stress control, defined as programs and policies to prevent, identify, and manage adverse combat/operational stress reactions, is the primary responsibility of military commanders...

  19. Responsive Innovation

    DEFF Research Database (Denmark)

    Pedersen, Carsten

    In dynamic environments, competitive advantage lies in developing useful knowledge from continuous streams of unstructured and ambiguous data. Frontline employees and certain groups of customers are often the first to sense emerging issues of strate-gic importance due to their experiential insights...... of the firm’s daily operations. Yet, they are rarely asked to provide updated information about critical issues. The present paper seeks to conceptually develop the notion of responsive innovation, by drawing on literary streams concerning collective sensing, strategic issue diagnosis and integra......-tive strategy within a micro foundations perspective. It is posited that companies should root their innovation processes in the collective sensing of frontline-employees and customers that operate around the organizational periphery. This frames the con-cept of responsive innovation, where individuals engaged...

  20. Responsive Innovation

    DEFF Research Database (Denmark)

    Pedersen, Carsten

    Although the importance of stakeholder networks has been recognized in recent years, a non-teleological model that incorporates their collective sensing into innovation processes has so far not been developed. Hence, this paper argues that traditional linear and sequential innovation models...... are insufficient in hypercompetitive environments. Instead, it is proposed that companies should ground their innovation processes in the collective sensing of frontline-employees and customers that operate around the organizational periphery. This frames the concept of responsive innovation, where key...

  1. Monitoring of operating processes

    International Nuclear Information System (INIS)

    Barry, R.F.

    1981-01-01

    Apparatus is described for monitoring the processes of a nuclear reactor to detect off-normal operation of any process and for testing the monitoring apparatus. The processes are evaluated by response to their paramters, such as temperature, pressure, etc. The apparatus includes a pair of monitoring paths or signal processing units. Each unit includes facilities for receiving on a time-sharing basis, a status binary word made up of digits each indicating the status of a process, whether normal or off-normal, and test-signal binary words simulating the status binary words. The status words and test words are processed in succession during successive cycles. During each cycle, the two units receive the same status word and the same test word. The test words simulate the status words both when they indicate normal operation and when they indicate off-normal operation. Each signal-processing unit includes a pair of memories. Each memory receives a status word or a test word, as the case may be, and converts the received word into a converted status word or a converted test word. The memories of each monitoring unit operate into a non-coincidence which signals non-coincidence of the converted word out of one memory of a signal-processing unit not identical to the converted word of the other memory of the same unit

  2. Seismic response to power production at the Coso Geothermal field, south-eastern CA: using operational parameters and relocated events to study anthropogenic seismicity rates and reservoir scale tectonic structure

    Science.gov (United States)

    Lajoie, L. J.; O'Connell, D. R.; Creed, R. J.; Brodsky, E. E.

    2013-12-01

    The United States is increasing its dependence on renewable energies and with that has come an interest in expanding geothermal operations. Due to the proximity of many existing and potential geothermal sites to population centers and seismically active regions, it is important to understand how geothermal operations interact with local (and regional) seismicity, and to determine if seismicity rates are predictable from operational parameters (i.e. fluid injection, production, and net fluid extraction) alone. Furthermore, geothermal injection and production strategies can be improved by identifying, locating and characterizing related earthquakes within the tectonic related background seismicity. As the geothermal production related seismic source focal mechanisms, moment, and location are better characterized, important pragmatic questions (such as the improvement of injection strategies and 3-d thermohydromechanical model validation) and research issues (such as the relationship between far field seismic signals, local rheology changes, and native state reservoir stress evolution as a function of injection and production transients) can be more systematically addressed. We focus specifically on the 270 MW Coso geothermal field in south-eastern California, which is characterized by both high seismicity rates and relatively high aftershock triggering. After performing statistical de-clustering of local seismicity into background and aftershock rates, we show that the background rate (at both the Coso and Salton Sea geothermal fields) can be approximated during many time intervals at the 90% + confidence level by a linear combination of injection volume and the net extracted volume (difference between production and injection). Different magnitude ranges are sampled to determine if the response is constant with respect to magnitude. We also use relative relocations and focal mechanisms from Yang et al. (2012) to map fault planes within the Coso geothermal field. We

  3. NRC operation center's function

    International Nuclear Information System (INIS)

    Weiss, E.W.

    1987-01-01

    The Nuclear Regulatory Commission has maintained a 24-hour-a-day, 365 days-a-year, manned Operations Center since the emergency incident at the Three Mile Island Nuclear Power Plant in 1979. The Center functions as the NRC's point of direct communication through dedicated telephone lines for reports of significant events at licensed nuclear power plants and certain fuel cycle facilities. The Center has become a key element in the agency's emergency preparedness. The effectiveness of the NRC Operations Center depends in large measure on complete and accurate reports from the licensees. The information provided is used to: identify generic safety issues and precursor events that may compromise plant safety; develop licensee performance trends that are used to adjust NRC regulatory emphasis; and, evaluate and provide for the appropriate NRC response to events in a real time mode

  4. The Contribution of Novel CP Violating Operators to the nEDM using Lattice QCD

    Directory of Open Access Journals (Sweden)

    Gupta Rajan

    2017-01-01

    Full Text Available In this talk, we motivate the calculation of the matrix elements of novel CP violating operators, the quark EDM and the quark chromo EDM operators, within the nucleon state using lattice QCD. These matrix elements, combined with the bound on the neutron EDM, would provide stringent constraints on beyond the standard model physics, especially as the next generation of neutron EDM experiments reduce the current bound. We then present our lattice strategy for the calculation of these matrix elements, in particular we describe the use of the Schrodinger source method to reduce the calculation of the 4-point to 3-point functions needed to evaluate the quark chromo EDM contribution. We end with a status report on the quality of the signal obtained in the lattice calculations of the connected contributions to the quark chromo EDM operator and the pseudoscalar operator it mixes with under renormalization.

  5. Operator theory, operator algebras and applications

    CERN Document Server

    Lebre, Amarino; Samko, Stefan; Spitkovsky, Ilya

    2014-01-01

    This book consists of research papers that cover the scientific areas of the International Workshop on Operator Theory, Operator Algebras and Applications, held in Lisbon in September 2012. The volume particularly focuses on (i) operator theory and harmonic analysis (singular integral operators with shifts; pseudodifferential operators, factorization of almost periodic matrix functions; inequalities; Cauchy type integrals; maximal and singular operators on generalized Orlicz-Morrey spaces; the Riesz potential operator; modification of Hadamard fractional integro-differentiation), (ii) operator algebras (invertibility in groupoid C*-algebras; inner endomorphisms of some semi group, crossed products; C*-algebras generated by mappings which have finite orbits; Folner sequences in operator algebras; arithmetic aspect of C*_r SL(2); C*-algebras of singular integral operators; algebras of operator sequences) and (iii) mathematical physics (operator approach to diffraction from polygonal-conical screens; Poisson geo...

  6. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Safety Resources About the Patient Education Program The Recovery Room Choosing Wisely Educational Programs Educational Programs Educational ... Lung Operation After Your Operation Your Discharge and Recovery Complete Video After Your Operation Guidance for after ...

  7. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Overview ACS-AEI Consortium Quarterly ACS Chapter News Cancer ... American College of Surgeons Education Patients and Family Skills Programs Your Lung Operation Your Lung Operation DVD After Your Operation ...

  8. Operating Experience at NPP Krsko

    International Nuclear Information System (INIS)

    Kavsek, D.; Bach, B.

    1998-01-01

    Systematic analysis of operational experience by assessment of internal and industry events and the feedback of lessons learned is one of the essential activities in the improvement of the operational safety and reliability of the nuclear power plant. At NPP Krsko we have developed a document called ''Operating Experience Assessment Program''. Its purpose is to establish administrative guidance for the processing of operating events including on-site and industry events. Assessment of internal events is based on the following methods: Event and Causal Factor Charting, Change Analysis, Barrier Analysis, MORT (Management Oversight and Risk Tree Analysis) and Human Performance Evaluation. The operating experience group has developed a sophisticated program entitled ''Operating experience tracking system'' (OETS) in response to the need for a more efficient way of processing internal and industry operating experience information. The Operating Experience Tracking System is used to initiate and track operational events including recommended actions follow up. Six screens of the system contain diverse essential information which allows tracking of operational events and enables different kinds of browsing. OETS is a part of the NPP Krsko nuclear network system and can be easily accessed by all plant personnel. (author)

  9. Operation Brain Trauma Therapy

    Science.gov (United States)

    2012-10-01

    IL‐1B and MIP‐2  concentrations   reduced  NONE  Brain  conc at 4, 8,  12, or 24h; Dose  response seen;  5000 IV gave  highest  brain  conc  18/Xiong et...by the Operation Brain Trauma Therapy consortium Drugs Secondary Injury Mechanisms Inflammation Axonal Injury Excitotoxicity/ Neurotransmitter ...glutamatergic transmission in the prefrontal cortex of stroke-prone spontaneously hypertensive rats. Neurosci Lett. 2002;320:109–112. 45. Nakamura K

  10. Nuclear reactor operator licensing

    International Nuclear Information System (INIS)

    Bursey, R.J.

    1978-01-01

    The Atomic Energy Act of 1954, which was amended in 1974 by the Energy Reorganization Act, established the requirement that individuals who had the responsibility of operating the reactors in nuclear power plants must be licensed. Section 107 of the act states ''the Commission shall (1) prescribe uniform conditions for licensing individuals; (2) determine the qualifications of such individuals; and (3) issue licenses to such individuals in such form as the Commission may prescribe.'' The article discusses the types of licenses, the selection and training of individuals, and the administration of the Nuclear Regulatory Commission licensing examinations

  11. The impact of minimum pay implementation on small businesses operating cost and sustainability: A case of service business

    Directory of Open Access Journals (Sweden)

    Hanim Rusly Fariza

    2017-01-01

    Full Text Available The implementation of minimum wage requirement in Malaysia beginning mid 2016 seems to impact both employees and employers in different ways. While this implementation could increase household income and claimed to boost employees’ productivity, employers or business operators, on the other hand are experiencing stringent effect on their business operating cost. The effect is more significant for small business operators, including the childcare centers. Childcare industry operates in the service sector, which represents the main contributor of Malaysian SMEs. Unfortunately for the industry, there is an increasing numbers of childcare centers have to cease their operation due to inability to comply with the minimum pay requirement. In the absence of thorough understanding of the phenomena, the small businesses, particularly among institution-based childcare, is at the risk of losing their businesses. This exploratory study intends to assess how the implementation of minimum pay requirement affects the existing operating cost structure, and consequently business sustainability of Malaysian childcare industry.

  12. ICD Complex Operations and Maintenance Plan

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, P. L.

    2007-06-25

    This Operations and Maintenance (O&M) Plan describes how the Idaho National Laboratory (INL) conducts operations, winterization, and startup of the Idaho CERCLA Disposal Facility (ICDF) Complex. The ICDF Complex is the centralized INL facility responsible for the receipt, storage, treatment (as necessary), and disposal of INL Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) remediation waste.

  13. Host City Contract operational requirements

    OpenAIRE

    2015-01-01

    The Host City Contract - Operational Requirements (the “HCC Operational Requirements”) are an important part of the Host City Contract, detailing a set of core elements for the project, which provide Olympic quality conditions for the athletes and all participants, while at the same time allowing potential host cities to responsibly match their Games concepts to their own sport, economic, social, and environmental long-term planning needs.

  14. Depth of interaction and bias voltage depenence of the spectral response in a pixellated CdTe detector operating in time-over-threshold mode subjected to monochromatic X-rays

    Science.gov (United States)

    Fröjdh, E.; Fröjdh, C.; Gimenez, E. N.; Maneuski, D.; Marchal, J.; Norlin, B.; O'Shea, V.; Stewart, G.; Wilhelm, H.; Modh Zain, R.; Thungström, G.

    2012-03-01

    High stopping power is one of the most important figures of merit for X-ray detectors. CdTe is a promising material but suffers from: material defects, non-ideal charge transport and long range X-ray fluorescence. Those factors reduce the image quality and deteriorate spectral information. In this project we used a monochromatic pencil beam collimated through a 20μm pinhole to measure the detector spectral response in dependance on the depth of interaction. The sensor was a 1mm thick CdTe detector with a pixel pitch of 110μm, bump bonded to a Timepix readout chip operating in Time-Over-Threshold mode. The measurements were carried out at the Extreme Conditions beamline I15 of the Diamond Light Source. The beam was entering the sensor at an angle of \\texttildelow20 degrees to the surface and then passed through \\texttildelow25 pixels before leaving through the bottom of the sensor. The photon energy was tuned to 77keV giving a variation in the beam intensity of about three orders of magnitude along the beam path. Spectra in Time-over-Threshold (ToT) mode were recorded showing each individual interaction. The bias voltage was varied between -30V and -300V to investigate how the electric field affected the spectral information. For this setup it is worth noticing the large impact of fluorescence. At -300V the photo peak and escape peak are of similar height. For high bias voltages the spectra remains clear throughout the whole depth but for lower voltages as -50V, only the bottom part of the sensor carries spectral information. This is an effect of the low hole mobility and the longer range the electrons have to travel in a low field.

  15. MIPAS level 2 operational analysis

    Directory of Open Access Journals (Sweden)

    P. Raspollini

    2006-01-01

    Full Text Available The MIPAS (Michelson Interferometer for Passive Atmospheric Sounding instrument has been operating on-board the ENVISAT satellite since March 2002. In the first two years, it acquired in a nearly continuous manner high resolution (0.025 cm−1 unapodized emission spectra of the Earth's atmosphere at limb in the middle infrared region. This paper describes the level 2 near real-time (NRT and off-line (OL ESA processors that have been used to derive level 2 geophysical products from the calibrated and geolocated level 1b spectra. The design of the code and the analysis methodology have been driven by the requirements for NRT processing. This paper reviews the performance of the optimized retrieval strategy that has been implemented to achieve these requirements and provides estimated error budgets for the target products: pressure, temperature, O3, H2O, CH4, HNO3, N2O and NO2, in the altitude measurement range from 6 to 68 km. From application to real MIPAS data, it was found that no change was needed in the developed code although an external algorithm was introduced to identify clouds with high opacity and to exclude affected spectra from the analysis. In addition, a number of updates were made to the set-up parameters and to auxiliary data. In particular, a new version of the MIPAS dedicated spectroscopic database was used and, in the OL analysis, the retrieval range was extended to reduce errors due to uncertainties in extrapolation of the profile outside the retrieval range and more stringent convergence criteria were implemented. A statistical analysis on the χ2 values obtained in one year of measurements shows good agreement with the a priori estimate of the forward model errors. On the basis of the first two years of MIPAS measurements the estimates of the forward model and instrument errors are in general found to be conservative with excellent performance demonstrated for frequency calibration. It is noted that the total retrieval

  16. Deployable Network Operations Center (DNOC): A Collaborative Technology Infostructure Designed to Support Tactical Sensor-Decision Maker Network Operations

    National Research Council Canada - National Science Library

    Johnson, Shawn E

    2005-01-01

    .... The increasing use of expeditionary and special operations forces operating in ad hoc, dynamic, and tactical environments poses a need for an adaptable, flexible, and responsive Deployable Network Operations Center (DNOC...

  17. Sustainability in Fashion Business Operations

    Directory of Open Access Journals (Sweden)

    Tsan-Ming Choi

    2015-11-01

    Full Text Available Under the global trend of sustainability, many companies selling fashion products have to reshape their operational strategies. Over the past few years, we have witnessed many fashion companies going green by re-engineering their business processes and establishing their formal sustainability programs. Many important topics, such as closed-loop supply chain management, corporate social responsibility, and economic sustainability, are all related to sustainable fashion business operations management. This paper provides a brief review of these critical topics, introduces the special issue, and proposes future research areas to achieve sustainable operations management in the fashion business.

  18. Reactor operations at SAFARI-1

    International Nuclear Information System (INIS)

    Vlok, J.W.H.

    2003-01-01

    A vigorous commercial programme of isotope production and other radiation services has been followed by the SAFARI-1 research reactor over the past ten years - superimposed on the original purpose of the reactor to provide a basic tool for nuclear research, development and education to the country at an institutional level. A combination of the binding nature of the resulting contractual obligations and tighter regulatory control has demanded an equally vigorous programme of upgrading, replacement and renovation of many systems in order to improve the safety and reliability of the reactor. Not least among these changes is the more effective training and deployment of operations personnel that has been necessitated as the operational demands on the reactor evolved from five days per week to twenty four hours per day, seven days per week, with more than 300 days per year at full power. This paper briefly sketches the operational history of SAFARI-1 and then focuses on the training and structuring currently in place to meet the operational needs. There is a detailed step-by-step look at the operator?s career plan and pre-defined milestones. Shift work, especially the shift cycle, has a negative influence on the operator's career path development, especially due to his unavailability for training. Methods utilised to minimise this influence are presented. The increase of responsibilities regarding the operation of the reactor, ancillaries and experimental facilities as the operator progresses with his career are discussed. (author)

  19. A Survey on Operator Monotonicity, Operator Convexity, and Operator Means

    Directory of Open Access Journals (Sweden)

    Pattrawut Chansangiam

    2015-01-01

    Full Text Available This paper is an expository devoted to an important class of real-valued functions introduced by Löwner, namely, operator monotone functions. This concept is closely related to operator convex/concave functions. Various characterizations for such functions are given from the viewpoint of differential analysis in terms of matrix of divided differences. From the viewpoint of operator inequalities, various characterizations and the relationship between operator monotonicity and operator convexity are given by Hansen and Pedersen. In the viewpoint of measure theory, operator monotone functions on the nonnegative reals admit meaningful integral representations with respect to Borel measures on the unit interval. Furthermore, Kubo-Ando theory asserts the correspondence between operator monotone functions and operator means.

  20. The IAEAs incident and emergency centre: the global focal point for nuclear and radiological emergency preparedness and response

    International Nuclear Information System (INIS)

    Buglova, E.

    2016-01-01

    The continuous use of nuclear power to generate electricity and the continued threat of radioactive materials being used for nefarious reasons reminds us of the importance to stay prepared to respond to nuclear or radiological emergencies. Stringent nuclear safety and nuclear security requirements, the training of personnel, operational checks and legal frameworks cannot always prevent radiation-related emergencies. Though these events can range in severity, each has the potential to cause harm to the public, employees, patients, property and the environment. Until the Chernobyl nuclear accident in 1986, there was no international information exchange system. Immediately following that accident, the international community negotiated the so-called Emergency Conventions to ensure that the country suffering an accident with an international transboundary release of radioactive material would issue timely, authenticated information, while the States that could field technical support, would do so in a coordinated fashion. The Conventions also place specific legal obligations on the International Atomic energy Agency (IAEA) with regard to emergency preparedness and response. (Author)

  1. The IAEAs incident and emergency centre: the global focal point for nuclear and radiological emergency preparedness and response

    Energy Technology Data Exchange (ETDEWEB)

    Buglova, E.

    2016-08-01

    The continuous use of nuclear power to generate electricity and the continued threat of radioactive materials being used for nefarious reasons reminds us of the importance to stay prepared to respond to nuclear or radiological emergencies. Stringent nuclear safety and nuclear security requirements, the training of personnel, operational checks and legal frameworks cannot always prevent radiation-related emergencies. Though these events can range in severity, each has the potential to cause harm to the public, employees, patients, property and the environment. Until the Chernobyl nuclear accident in 1986, there was no international information exchange system. Immediately following that accident, the international community negotiated the so-called Emergency Conventions to ensure that the country suffering an accident with an international transboundary release of radioactive material would issue timely, authenticated information, while the States that could field technical support, would do so in a coordinated fashion. The Conventions also place specific legal obligations on the International Atomic energy Agency (IAEA) with regard to emergency preparedness and response. (Author)

  2. State and outlooks of remote handling and automation techniques use for industrial radioactive operations

    International Nuclear Information System (INIS)

    Guilloteau, R.; Le Guennec, R.; Dumond, S.

    1981-01-01

    Handling in reactors mainly concerns charging and discharging operations and inspection. Specific means are being developed for each operation, with an increasing degree of automation. This serves to reduce exposure of personnel. However, the development of these means conflicts in certain cases with the original plant design, which did not provide for remote maintenance. With regard to fuel reprocessing, handling at the processing level is becoming increasingly automated. The difficulties lie principally in maintenance and waste conditioning operations. These involve less specialized means than is the case with reactors and can only be automated to a limited extent, save in exceptional cases. The greatest progress will be achieved by laying down stringent maintenance principles and taking them into consideration at the design stage

  3. Trainer module for security control center operations

    International Nuclear Information System (INIS)

    Bernard, E.A.

    1982-01-01

    An operator trainer module has been developed to be used with the security control center equipment to be installed as part of a safeguards physical protection system. The module is designed to provide improved training and testing capabilities for control center operators through the use of simulations for perimeter equipment operations. Operators, through the trainer module, can be challenged with a variety of realistic situations which require responsive action identical to that needed in an actual system. This permits a consistent evaluation and confirmation of operator capabilities prior to assignment as an operator and allows for periodic retesting to verify that adequate performance levels are maintained

  4. The Social Licence to Operate

    NARCIS (Netherlands)

    Meesters, Marieke Evelien; Behagel, Jelle Hendrik

    2017-01-01

    The Social Licence to Operate (SLO) is increasingly used in extractive industries both as a response to calls for greater community engagement and as a corporate sustainability strategy. Given its current popularity as a policy instrument, critiques on the SLO deserve attention. Critiques mainly

  5. Organization for field operator training

    International Nuclear Information System (INIS)

    Boizet, F.; Dejou, P.

    1996-01-01

    Organization for field operator training is described, dealing with 4 strong ambitions: deliberate policy of encouraging the staff to accept greater personal responsibilities; on shift and off shift support to allow this acceptation; continuous enhancement of individual and team professionalism; reinforcement of the management

  6. Sensitivity mapping of the German North Sea Coast II. Data update and development of an operational model for precaution measures of oil spill response; Sensititivaetsraster Deutsche Nordseekueste II. Aktualisierung und Erstellung eines operationellen Modells zur Vorsorgeplanung bei der Oelbekaempfung

    Energy Technology Data Exchange (ETDEWEB)

    Bernem, K.H. van; Doerffer, R.; Heymann, K.; Kleeberg, U.; Krasemann, H.; Schiller, H. [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Kuestenforschung; Grohnert, A.; Reichert, J. [IfaB - Institut fuer Angewandte Biologie Freiburg/Niederelbe (Germany); Reichert, M. [ARCADIS, Rostock (Germany)

    2007-07-01

    The Wadden Sea is an area of tidal flats and salt marshes extending between the North Sea coasts of Denmark, Germany and the Netherlands. It has enormous value as a cleansing site for North Sea water, as a nursery for young fish and as a feeding ground for many bird species. Due to the proximity of important shipping routes and harbours, this region is especially threatened by oil spills. Thus, for oil spill response and precaution measures, a sensitivity study of the entire intertidal area was badly needed in order to assess and minimize the potential ecological and economical damage. Based on comprehensive field surveys and in close cooperation with the Central Command for Maritime Emergencies, an automated expert-model for the german part of Wadden Sea areas was developed at the Institute for Coastal Research (GKSS-Research Centre). As an operational model it will serve as important instrument for decision making processes, precautionary measures and the further design of oil spill response strategies. Since it is not possible to protect the entire German North Sea coast equally at all levels, oil spill contingency planning requires a more detailed classification. For this reason, individual soft bottom habitats, communities and stocks of saltmarshes, macrofauna, waterfowl and estuarine biotop types were evaluated and classified according to their vulnerability to oil pollution. Hence, the fieldwork for habitat mapping during 2003-2006 was a central part of the study. For this part, the experiences and results obtained from the previous GKSS-project ''Thematic mapping and sensitivity study of Intertidal flats'' during the years 1987-1992 served as an valuable basis. For example, the documentation of changes during these periods of observation provides information on stability features of the ecosystems. During the first project nearly 5000 locations were processed and characterised using about 70 parameters for each site. The in-situ mapping

  7. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Careers at ACS Careers at ACS About ACS Career Types Working at ACS ... ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Your Lung Operation Your Lung Operation DVD ...

  8. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Participate Resources Webinars for Young Surgeons YFA E-News Resident and Associate Society Resident and Associate Society ... Leader International Exchange Scholar Program Resources RAS E-News Medical Students Operation Giving Back Operation Giving Back ...

  9. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... to Participate Resources Webinars for Young Surgeons YFA E-News Resident and Associate Society Resident and Associate ... ACS Leader International Exchange Scholar Program Resources RAS E-News Medical Students Operation Giving Back Operation Giving ...

  10. Transportation System Concept of Operations

    Energy Technology Data Exchange (ETDEWEB)

    N. Slater-Thompson

    2006-08-16

    The Nuclear Waste Policy Act of 1982 (NWPA), as amended, authorized the DOE to develop and manage a Federal system for the disposal of SNF and HLW. OCRWM was created to manage acceptance and disposal of SNF and HLW in a manner that protects public health, safety, and the environment; enhances national and energy security; and merits public confidence. This responsibility includes managing the transportation of SNF and HLW from origin sites to the Repository for disposal. The Transportation System Concept of Operations is the core high-level OCRWM document written to describe the Transportation System integrated design and present the vision, mission, and goals for Transportation System operations. By defining the functions, processes, and critical interfaces of this system early in the system development phase, programmatic risks are minimized, system costs are contained, and system operations are better managed, safer, and more secure. This document also facilitates discussions and understanding among parties responsible for the design, development, and operation of the Transportation System. Such understanding is important for the timely development of system requirements and identification of system interfaces. Information provided in the Transportation System Concept of Operations includes: the functions and key components of the Transportation System; system component interactions; flows of information within the system; the general operating sequences; and the internal and external factors affecting transportation operations. The Transportation System Concept of Operations reflects OCRWM's overall waste management system policies and mission objectives, and as such provides a description of the preferred state of system operation. The description of general Transportation System operating functions in the Transportation System Concept of Operations is the first step in the OCRWM systems engineering process, establishing the starting point for the lower

  11. Operational diver monitoring

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The requirements of the contract under which this work was performed were simple. It was required that we should bring back sleep and other physiological data from divers in the working environment. This we have done. The two divers studied do not give us sufficient evidence upon which to base conclusive statements, though the rapidity with which a normal sleep pattern was established in both divers suggests to us that operational demand rather than any hyperbaric influence on sleep physiology is the major factor causing fatigue offshore. The temperature work reported is an additional study, not originally contained in the contract. The work was performed in response to a need for information from Oceaneering/Vickers Oceanics and we thank them for the opportunity. This work shows that divers using their system do undoubtably get cold, but that the recently introduced space undersuit provides considerable protection. (UK)

  12. Categorizing operational radioactive wastes

    International Nuclear Information System (INIS)

    2007-04-01

    The primary objective of this publication is to improve communications among waste management professionals and Member States relative to the properties and status of radioactive waste. This is accomplished by providing a standardized approach to operational waste categorization using accepted industry practices and experience. It is a secondary objective to draw a distinction between operational waste categorization and waste disposal classification. The approach set forth herein is applicable to waste generation by mature (major, advanced) nuclear programmes, small-to-medium sized nuclear programmes, and programmes with waste from other nuclear applications. It can be used for planning, developing or revising categorization methodologies. For existing categorization programmes, the approach set forth in this publication may be used as a validation and evaluation tool for assessing communication effectiveness among affected organizations or nations. This publication is intended for use by waste management professionals responsible for creating, implementing or communicating effective categorization, processing and disposal strategies. For the users of this publication, it is important to remember that waste categorization is a communication tool. As such, the operational waste categories are not suitable for regulatory purposes nor for use in health and safety evaluations. Following Section 1 (Introduction) Section 2 of this publication defines categorization and its relationship to existing waste classification and management standards, regulations and practices. It also describes the benefits of a comprehensive categorization programme and fundamental record considerations. Section 3 provides an overview of the categorization process, including primary categories and sub-categories. Sections 4 and 5 outline the specific methodology for categorizing unconditioned and conditioned wastes. Finally, Section 6 provides a brief summary of critical considerations that

  13. HFETR operation management

    International Nuclear Information System (INIS)

    Liu Rong; Yang Shuchun; Peng Jun; Zhou Shoukang

    2003-01-01

    Experiences and work methods with High Flux Engineering Test Reactor (HFETR) operation are introduced, which have been accumulated in a long period of operation, in the aspects as reactor operation, test, maintenance, operator training and incident management. It's clear that the safety operation of HFETR has been ensured, and the methods are valid. (authors)

  14. Operating experience and design criteria of sodium valves

    International Nuclear Information System (INIS)

    Markford, D.

    1974-01-01

    The information presented refers to sodium valve development for KNK and SNR-300 as well as for sodium test facilities on the INTERATOM site at Bensberg. Well in advance of KNK-I a number of sodium test facilities have been operated containing small and medium size valves of different design and manufacturer. The more stringent requirements for long range safe and reliable operation in KNK-I put forth a development program for the main primary and secondary circuit sodium valves. Operational experience gave rise to modification of the stem seal arrangement mainly, so KNK-II (which is the fast core for KNK reactor) will be run with modified sodium valves. Main pipe diameters in SNR-300 are in the range of 600 mm. Valve designs with rising shafts would require excessive space in the primary circuit cavities, therefore efforts have been directed towards introduction of different type valves. Due to the requirements of after-heat-removal a valve type with control capability had to be chosen. A special design of butterfly valves was selected for the primary and secondary circuits of SNR-300. The development and tests performed with this type of valve are described. In the field of small sodium valves, tests with a 50 mm diameter freeze-seal valve are reported, and the current status of bellows-seal-valves to be inserted into SNR-300 is discussed. (U.S.)

  15. Psychological aspects of peacekeeping operations

    Directory of Open Access Journals (Sweden)

    M. S. V. K. Raju

    2014-01-01

    Full Text Available Peacekeeping operations are but one aspect of the systems of peace that have evolved over the past seven decades in a world that is riven with violence of all kinds. With the end of cold war in the late eighties of the last century we have come to see much intrastate violence, in addition to usual interstate hostilities and war, arising out of religious, political, ethnic and economic differences between people. In the changed scenario peacekeeping operations have become complex politico-military-humanitarian efforts. A soldier, trained for conventional military operations, is obliged to participate in the unconventional operations of waging peace in alien lands often in volatile and violent situations and in the process he stands to get exposed to widely variable demands for adjustment that have the potential to bring to the fore many maladaptive responses. Peacekeeping operations also have the potential to offer opportunities for growth and resilience. India is a major player in peacekeeping activities for well over sixty years all over the world. It is necessary for the commanders and mental health professionals to understand the multifarious factors that impinge on the peacekeeping soldier′s mind and the emerging patterns of responses thereof for effective management trained manpower and fulfillment of mission objectives

  16. Psychological aspects of peacekeeping operations.

    Science.gov (United States)

    Raju, M S V K

    2014-01-01

    Peacekeeping operations are but one aspect of the systems of peace that have evolved over the past seven decades in a world that is riven with violence of all kinds. With the end of cold war in the late eighties of the last century we have come to see much intrastate violence, in addition to usual interstate hostilities and war, arising out of religious, political, ethnic and economic differences between people. In the changed scenario peacekeeping operations have become complex politico-military-humanitarian efforts. A soldier, trained for conventional military operations, is obliged to participate in the unconventional operations of waging peace in alien lands often in volatile and violent situations and in the process he stands to get exposed to widely variable demands for adjustment that have the potential to bring to the fore many maladaptive responses. Peacekeeping operations also have the potential to offer opportunities for growth and resilience. India is a major player in peacekeeping activities for well over sixty years all over the world. It is necessary for the commanders and mental health professionals to understand the multifarious factors that impinge on the peacekeeping soldier's mind and the emerging patterns of responses thereof for effective management trained manpower and fulfillment of mission objectives.

  17. Heat transfer operators associated with quantum operations

    International Nuclear Information System (INIS)

    Aksak, C; Turgut, S

    2011-01-01

    Any quantum operation applied on a physical system is performed as a unitary transformation on a larger extended system. If the extension used is a heat bath in thermal equilibrium, the concomitant change in the state of the bath necessarily implies a heat exchange with it. The dependence of the average heat transferred to the bath on the initial state of the system can then be found from the expectation value of a Hermitian operator, which is named as the heat transfer operator (HTO). The purpose of this paper is to investigate the relation between the HTOs and the associated quantum operations. Since any given quantum operation on a system can be realized by different baths and unitaries, many different HTOs are possible for each quantum operation. On the other hand, there are also strong restrictions on the HTOs which arise from the unitarity of the transformations. The most important of these is the Landauer erasure principle. This paper is concerned with the question of finding a complete set of restrictions on the HTOs that are associated with a given quantum operation. An answer to this question has been found only for a subset of quantum operations. For erasure operations, these characterizations are equivalent to the generalized Landauer erasure principle. For the case of generic quantum operations, however, it appears that the HTOs obey further restrictions which cannot be obtained from the entropic restrictions of the generalized Landauer erasure principle.

  18. Transit operator absenteeism.

    Science.gov (United States)

    1985-01-01

    A nationwide survey of transit operators indicated that absenteeism among transit operators is a significant problem and that the associated costs are substantial. The objective of the research reported here was to determine the scope of operator abs...

  19. Participation in testing and start up operations

    International Nuclear Information System (INIS)

    Prasad, Y.S.R.

    1977-01-01

    Testing and start up operations of a nuclear power plant require careful planning. A detailed program of tests and the responsibility of implementing them is discussed. Requirement of documentation covering the tests and operating procedures is explained. The performance of the system during normal and abnomal operating conditions is analysed and required are modifications carried out. Various phases of commissioning and their significance are explained. Preparation of maintenance documentation and training of operating and maintenance staff during this period are discussed. Necessity of close liaison between the regulatory body and the operating organization is explained. (orig.) [de

  20. Store operations to maintain cache coherence

    Energy Technology Data Exchange (ETDEWEB)

    Evangelinos, Constantinos; Nair, Ravi; Ohmacht, Martin

    2017-09-12

    In one embodiment, a computer-implemented method includes encountering a store operation during a compile-time of a program, where the store operation is applicable to a memory line. It is determined, by a computer processor, that no cache coherence action is necessary for the store operation. A store-without-coherence-action instruction is generated for the store operation, responsive to determining that no cache coherence action is necessary. The store-without-coherence-action instruction specifies that the store operation is to be performed without a cache coherence action, and cache coherence is maintained upon execution of the store-without-coherence-action instruction.

  1. Store operations to maintain cache coherence

    Energy Technology Data Exchange (ETDEWEB)

    Evangelinos, Constantinos; Nair, Ravi; Ohmacht, Martin

    2017-08-01

    In one embodiment, a computer-implemented method includes encountering a store operation during a compile-time of a program, where the store operation is applicable to a memory line. It is determined, by a computer processor, that no cache coherence action is necessary for the store operation. A store-without-coherence-action instruction is generated for the store operation, responsive to determining that no cache coherence action is necessary. The store-without-coherence-action instruction specifies that the store operation is to be performed without a cache coherence action, and cache coherence is maintained upon execution of the store-without-coherence-action instruction.

  2. Conduct of operations: establishing operational focus and setting operational standards

    International Nuclear Information System (INIS)

    Lane, L.; McGuigan, K.

    1998-01-01

    Due to the nature of our business, we have often tended to focus on the technological aspects of the nuclear industry. The focus of this paper is directed towards the importance of addressing the people skills, attitudes, and 'culture' within, and surrounding, our facilities as key areas of improvement. Within Ontario Hydro Nuclear (OLIN) we have developed the terminology 'event free' operation and 'event free' culture. 'Event Free' recognizes errors as a part of human performance. 'Event Free' takes into account human weaknesses, and provides tools (such as standards) to manage, control, and mitigate errors. In essence, 'Event Free' encompasses two concepts: 1. Prevent errors from occurring; 2. If an error is made, catch it before it can affect safe operation of the facility, learn from the error, and ensure that it does not happen again. In addressing these business realities, Ontario Hydro has identified a number of key support mechanisms and corresponding performance standards that are essential for achieving operating excellence and an 'event free' business culture. This paper will discuss two operational aspects of an 'event free' culture, the first being a set of expectations to enhance the culture, and the second an example of cultural change: 1. Operating Standards - establishing clear expectations for human performance in operating staff; 2. Operational Focus - the understanding that, as a nuclear worker, you should consider every task, activity, in fact everything you do in this business, for the potential to affect safe and reliable operation of a nuclear facility. Note that although the term 'Operational' appears in the title, this concept applies to every individual in the nuclear business, from the cleaner, to the Board of Directors, to the external supplier. (author)

  3. Foreign Operation Methods

    DEFF Research Database (Denmark)

    Welch, Lawrence S.; Benito, Gabriel R. G.; Petersen, Bent

    Introduction and theory -- Introduction -- Theoretical approaches -- Modes of operation -- Franchising -- Licensing -- Management contracts -- International subcontracting -- Project operations -- Exports -- Alliances -- Foreign direct investment -- Strategies -- Mode switching and stretching...

  4. Autonomous Mission Operations

    Data.gov (United States)

    National Aeronautics and Space Administration — The AES Autonomous Mission Operations project will develop understanding of the impacts of increasing communication time delays on mission operations and develop...

  5. Saxton Transportation Operations Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Saxton Transportation Operations Laboratory (Saxton Laboratory) is a state-of-the-art facility for conducting transportation operations research. The laboratory...

  6. Crisis Management- Operational Logistics & Asset Visibility Technologies

    National Research Council Canada - National Science Library

    Braunbeck, Richard A; Mastria, Michael F

    2006-01-01

    .... Recent crisis response operations that would have benefited from improved asset visibility include the Indian Ocean tsunami, the Pakistani earthquake, Hurricane Katrina and those related to the Global War on Terror...

  7. Orbits of operators and operator semigroups

    Czech Academy of Sciences Publication Activity Database

    Müller, Vladimír

    -, č. 1737 (2011), s. 78-90 ISSN 1880-2818. [Noncommutative structure in operator theory and its application. Kyoto, 27.10.2010-29.10.2010] R&D Projects: GA ČR GA201/09/0473; GA AV ČR IAA100190903 Institutional research plan: CEZ:AV0Z10190503 Keywords : orbits of operators * hypercyclicity * semigroups of operators Subject RIV: BA - General Mathematics

  8. Recent U.S. reactor operating experience

    International Nuclear Information System (INIS)

    Stello, V. Jr.

    1977-01-01

    A qualitative assessment of U.S. and foreign reactor operating experience is provided. Recent operating occurrences having potentially significant safety impacts on power operation are described. An evaluation of the seriousness of each of these issues and the plans for resolution is discussed. A quantitative report on U.S. reactor operational experience is included. The details of the NRC program for evaluating and applying operating reactor experience in the regulatory process is discussed. A review is made of the adequacy of operating reactor safety and environmental margins based on actual operating experience. The Regulatory response philosophy to operating reactor experiences is detailed. This discussion indicates the NRC emphasis on the importance of a balanced action plan to provide for the protection of public safety in the national interest

  9. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Surgical Skills for Exposure in Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills for Trauma Disaster Management and Emergency ...

  10. Research nuclear reactor operation management

    International Nuclear Information System (INIS)

    Preda, M.; Carabulea, A.

    2008-01-01

    Some aspects of reactor operation management are highlighted. The main mission of the operational staff at a testing reactor is to operate it safely and efficiently, to ensure proper conditions for different research programs implying the use of the reactor. For reaching this aim, there were settled down operating plans for every objective, and procedure and working instructions for staff training were established, both for the start-up and for the safe operation of the reactor. Damages during operation or special situations which can arise, at stop, start-up, maintenance procedures were thoroughly considered. While the technical skill is considered to be the most important quality of the staff, the organising capacity is a must in the operation of any nuclear facility. Staff training aims at gaining both theoretical and practical experience based on standards about staff quality at each work level. 'Plow' sheet has to be carefully done, setting clear the decision responsibility for each person so that everyone's own technical level to be coupled to the problems which implies his responsibility. Possible events which may arise in operation, e.g., criticality, irradiation, contamination, and which do not arise in other fields, have to be carefully studied. One stresses that the management based on technical and scientific arguments have to cover through technical, economical and nuclear safety requirements a series of interlinked subprograms. Every such subprograms is subject to some peculiar demands by the help of which the entire activity field is coordinated. Hence for any subprogram there are established the objectives to be achieved, the applicable regulations, well-defined responsibilities, training of the personnel involved, the material and documentation basis required and activity planning. The following up of positive or negative responses generated by experiments and the information synthesis close the management scope. Important management aspects

  11. Separable quadratic stochastic operators

    International Nuclear Information System (INIS)

    Rozikov, U.A.; Nazir, S.

    2009-04-01

    We consider quadratic stochastic operators, which are separable as a product of two linear operators. Depending on properties of these linear operators we classify the set of the separable quadratic stochastic operators: first class of constant operators, second class of linear and third class of nonlinear (separable) quadratic stochastic operators. Since the properties of operators from the first and second classes are well known, we mainly study the properties of the operators of the third class. We describe some Lyapunov functions of the operators and apply them to study ω-limit sets of the trajectories generated by the operators. We also compare our results with known results of the theory of quadratic operators and give some open problems. (author)

  12. Responsibility and Responsiveness

    DEFF Research Database (Denmark)

    Nissen, Ulrik Becker

    2011-01-01

    contemporary positions of communicative ethics, H. Richard Niebuhr’s understanding of responsibility as responsiveness, and Dietrich Bonhoeffer’s Christological concept of responsibility in a constructive dialogue with each other, the article has attempted to outline main tenets of a responsive concept...... in a differentiated unity with each other. This idea can be substantiated by a figurative appropriation of a Chalcedonian Christology, particularly the communicatio idiomatum. The communicative dimension of this concept has been found to be useful for a reinterpretation of the idea of responsibility. By engaging......The debate on the role and identity of Christian social ethics in liberal democracy touches upon the question about the relationship between universality and speci-ficity. Rather than argue for the difference between these approaches, it can be argued that they are to be understood...

  13. Autonomous Satellite Operations Via Secure Virtual Mission Operations Center

    Science.gov (United States)

    Miller, Eric; Paulsen, Phillip E.; Pasciuto, Michael

    2011-01-01

    The science community is interested in improving their ability to respond to rapidly evolving, transient phenomena via autonomous rapid reconfiguration, which derives from the ability to assemble separate but collaborating sensors and data forecasting systems to meet a broad range of research and application needs. Current satellite systems typically require human intervention to respond to triggers from dissimilar sensor systems. Additionally, satellite ground services often need to be coordinated days or weeks in advance. Finally, the boundaries between the various sensor systems that make up such a Sensor Web are defined by such things as link delay and connectivity, data and error rate asymmetry, data reliability, quality of service provisions, and trust, complicating autonomous operations. Over the past ten years, researchers from the NASA Glenn Research Center (GRC), General Dynamics, Surrey Satellite Technology Limited (SSTL), Cisco, Universal Space Networks (USN), the U.S. Geological Survey (USGS), the Naval Research Laboratory, the DoD Operationally Responsive Space (ORS) Office, and others have worked collaboratively to develop a virtual mission operations capability. Called VMOC (Virtual Mission Operations Center), this new capability allows cross-system queuing of dissimilar mission unique systems through the use of a common security scheme and published application programming interfaces (APIs). Collaborative VMOC demonstrations over the last several years have supported the standardization of spacecraft to ground interfaces needed to reduce costs, maximize space effects to the user, and allow the generation of new tactics, techniques and procedures that lead to responsive space employment.

  14. Projection operator techniques in nonequilibrium statistical mechanics

    International Nuclear Information System (INIS)

    Grabert, H.

    1982-01-01

    This book is an introduction to the application of the projection operator technique to the statistical mechanics of irreversible processes. After a general introduction to the projection operator technique and statistical thermodynamics the Fokker-Planck and the master equation approach are described together with the response theory. Then, as applications the damped harmonic oscillator, simple fluids, and the spin relaxation are considered. (HSI)

  15. Developing Operator Models for UAV Search Scheduling

    NARCIS (Netherlands)

    Bertuccelli, L.F.; Beckers, N.W.M.; Cummings, M.L.

    2010-01-01

    With the increased use of Unmanned Aerial Vehicles (UAVs), it is envisioned that UAV operators will become high level mission supervisors, responsible for information management and task planning. In the context of search missions, operators supervising a large number of UAVs can become overwhelmed

  16. Gaps of operators

    Science.gov (United States)

    Jung, Il Bong; Lim, Pil Sang; Park, Sang Soo

    2005-04-01

    We construct examples which distinguish clearly the classes of p-hyponormal operators for 0normaloid operators on the complex Hilbert space. Only a few examples of p-hyponormal operators have been examined. Our technique can provide many examples related to the above operators.

  17. Strategic War Game - Arctic Response

    Science.gov (United States)

    2010-11-01

    Arctic Game Theory Strategic Analysis War Game ... Strategic War Game – Arctic Response A. P. Billyard I. A. Collin H. A. Hrychuk Canadian Forces Aerospace Warfare Center Operational...Operational Research Strategic War Game – Arctic Response A. P. Billyard I. A. Collin H. A. Hrychuk Canadian Forces Aerospace

  18. Composite operators in QCD

    International Nuclear Information System (INIS)

    Sonoda, Hidenori

    1992-01-01

    We give a formula for the derivatives of a correlation function of composite operators with respect to the parameters (i.e. the strong fine structure constant and the quark mass) of QCD in four- dimensional euclidean space. The formula is given as spatial integration of the operator conjugate to a parameter. The operator product of a composite operator and a conjugate operator has an unintegrable part, and the formula requires divergent subtractions. By imposing consistency conditions we drive a relation between the anomalous dimensions of the composite operators and the unintegrable part of the operator product coefficients. (orig.)

  19. The AECL operator companion

    International Nuclear Information System (INIS)

    Lupton, L.R.; Anderson, L.L.; Basso, R.A.J.

    1989-11-01

    As CANDU plants become more complex, and are operated under tighter constraints and for longer periods between outages, plant operations staff will have to absorb more information to correctly and rapidly respond to upsets. A development program is underway at AECL to use expert systems and interactive media tools to assist operations staff of existing and future CANDU plants. The complete system for plant information access and display, on-line advice and diagnosis, and interactive operating procedures is called the Operator Companion. A prototype, consisting of operator consoles, expert systems and simulation modules in a distributed architecture, is currently being developed to demonstrate the concepts of the Operator Companion

  20. Operation Safety Review of Nuclear Power Plant

    International Nuclear Information System (INIS)

    Suharno

    2005-01-01

    A review on operation safety of Nuclear Power Plant (NPP) is carried out. NPP is established through several phases that are siting, design, fabrication and construction, and after completion of construction the next phase is operation, therefore operating organization is established. The safety of NPP is relied on operation safety. Based on that case the aim of this review is to get impression that operating organization and its activities are very important on determining the achievement of operation safety. Operating organization determines qualification and training of personnel, commissioning programs, plant operation programs, and supporting activities programs. The method used in this review is by explains the operating organization and its activities. The results indicate that the role of operating organization and its activities are very important on determining the achievement of the goals of the operation which are secure, reliable and safe. Operating organization directly responsible to operation safety. Besides that, human factor related to the implementation of safety culture has also important role. (author)

  1. Operating pumps on minimum flow

    International Nuclear Information System (INIS)

    Casada, D.A.; Li, Y.C.

    1992-01-01

    The Nuclear Regulatory Commission (NRC) staff issued Information Notice (IN) 87-59 to alert all licensees to two miniflow design concerns identified by Westinghouse. The first potential problem discussed in this IN involves parallel pump operation. If the head/capacity curve of one of the parallel pumps is greater than the other, the weaker pump may be dead-headed when the pumps are operating at low-flow conditions. The other problem related to potential pump damage as a result of hydraulic instability during low-flow operation. In NRC Bulletin 88-04, dated May 5, 1988, the staff requested all licensees to investigate and correct, as applicable, the two miniflow design concerns. The staff also developed a Temporary Instruction, Tl 2515/105, dated January 29, 1990 to inspect for the adequacy of licensee response and follow-up actions to NRC Bulletin 88-04. Oak Ridge National Laboratory has reviewed utility responses to Bulletin 88-04 under auspices of the NRC's Nuclear Plant Aging Research Program, and participated in several NRC inspections. Examples of actions that have been taken, an assessment of the overall industry response, and resultant conclusions and recommendations are presented

  2. How to guide - transit operations decision support systems (TODSS).

    Science.gov (United States)

    2014-12-01

    Transit Operations Decision Support Systems (TODSS) are decision support systems designed to support dispatchers in real-time bus operations : management in response to incidents, special events, and other changing conditions in order to restore serv...

  3. 2016 National Census of Ferry Operators (Revised 03/18)

    Data.gov (United States)

    Department of Transportation — The 2016 NCFO dataset is comprised of the responses of all operators who completed the 2016 Census, reporting 2015 calendar year ferry operations. The NCFO Flat File...

  4. Constitutive and Operational Variation of Learning in Foraging Predatory Mites.

    Directory of Open Access Journals (Sweden)

    Michael Seiter

    Full Text Available Learning is widely documented across animal taxa but studies stringently scrutinizing the causes of constitutive or operational variation of learning among populations and individuals are scarce. The ability to learn is genetically determined and subject to constitutive variation while the performance in learning depends on the immediate circumstances and is subject to operational variation. We assessed variation in learning ability and performance of plant-inhabiting predatory mites, Amblyseius swirskii, caused by population origin, rearing diet, and type of experience. Using an early learning foraging paradigm, we determined that homogeneous single prey environments did not select for reduced learning ability, as compared to natural prey-diverse environments, whereas a multi-generational pollen diet resulted in loss of learning, as compared to a diet of live prey. Associative learning produced stronger effects than non-associative learning but both types of experience produced persistent memory. Our study represents a key example of environmentally caused variation in learning ability and performance.

  5. Elementary operators on self-adjoint operators

    Science.gov (United States)

    Molnar, Lajos; Semrl, Peter

    2007-03-01

    Let H be a Hilbert space and let and be standard *-operator algebras on H. Denote by and the set of all self-adjoint operators in and , respectively. Assume that and are surjective maps such that M(AM*(B)A)=M(A)BM(A) and M*(BM(A)B)=M*(B)AM*(B) for every pair , . Then there exist an invertible bounded linear or conjugate-linear operator and a constant c[set membership, variant]{-1,1} such that M(A)=cTAT*, , and M*(B)=cT*BT, .

  6. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Education Trauma Education Achieving Zero Preventable Deaths Trauma Systems Conference Advanced Surgical Skills for Exposure in Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills for ...

  7. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Up to Date with ACS Association Management JACS Jobs Events Find a Surgeon Patients and Family Contact My Profile Shop ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Your Lung Operation ...

  8. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Online Guide to Choosing a Surgical Residency Practice Management Workshops Patients and Family Patient Education Patient Education ... Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills for Trauma Disaster Management and ...

  9. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Education Trauma Education Achieving Zero Preventable Deaths Trauma Systems Conference Advanced Surgical Skills for Exposure in Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills for Trauma Disaster Management ...

  10. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... as pneumonia and deep vein thrombosis. Jump to: The Day of Your Lung Operation Read Next Your ... and Associates Medical Students International Surgeons Media ACS Links About ACS ACS Foundation Have a ...

  11. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... at ACS ACS and Veterans Diversity at ACS ... and Family Contact My Profile Shop ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Your Lung Operation ...

  12. Nonlocal Operational Calculi for Dunkl Operators

    Directory of Open Access Journals (Sweden)

    Ivan H. Dimovski

    2009-03-01

    Full Text Available The one-dimensional Dunkl operator $D_k$ with a non-negative parameter $k$, is considered under an arbitrary nonlocal boundary value condition. The right inverse operator of $D_k$, satisfying this condition is studied. An operational calculus of Mikusinski type is developed. In the frames of this operational calculi an extension of the Heaviside algorithm for solution of nonlocal Cauchy boundary value problems for Dunkl functional-differential equations $P(D_ku = f$ with a given polynomial $P$ is proposed. The solution of these equations in mean-periodic functions reduces to such problems. Necessary and sufficient condition for existence of unique solution in mean-periodic functions is found.

  13. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Stay Up to Date with ACS Association Management Jobs Events Find a Surgeon Patients and Family Contact My Profile Shop ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Your Lung Operation ...

  14. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Education Trauma Education Achieving Zero Preventable Deaths Trauma Systems Conference Advanced Surgical Skills for Exposure in Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills for Trauma Disaster Management and ...

  15. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Mentoring for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, Review, and Consultation Program for Hospitals ... Surgical Skills for Exposure in Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills ...

  16. Stability Operations: Learning from Operation Iraqi Freedom

    National Research Council Canada - National Science Library

    Clay, Troy A

    2007-01-01

    .... This paper examines some of these failures and analyzes the importance of security and its influence on using economic means during the initial stages of post-conflict operations to facilitate...

  17. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... ACS ACS and Veterans Diversity at ACS ... and Family Contact My Profile Shop ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Your Lung Operation ...

  18. Operating System Security

    CERN Document Server

    Jaeger, Trent

    2008-01-01

    Operating systems provide the fundamental mechanisms for securing computer processing. Since the 1960s, operating systems designers have explored how to build "secure" operating systems - operating systems whose mechanisms protect the system against a motivated adversary. Recently, the importance of ensuring such security has become a mainstream issue for all operating systems. In this book, we examine past research that outlines the requirements for a secure operating system and research that implements example systems that aim for such requirements. For system designs that aimed to

  19. Operations program plan: Revision 3

    International Nuclear Information System (INIS)

    1988-07-01

    This document, the Operations Program Plan (OPP), has been developed as the seven-year master plan for operation of WIPP. The OPP was authorized by the Albuquerque Field Office of the Department of Energy (DOE-AL) and that organization's WIPP Project Office (DOE-WPO) in Carlsbad, New Mexico. The OPP is the directive from the DOE-WPO Project Manager as to how the WIPP is to be managed, operated, and administered. As the top tier management document for WIPP, the OPP establishes organizational responsibilities and an organizational structure for the Waste Isolation Division (WID) of Westinghouse Electric Corporation. The OPP sets policy and tone for conducting WIPP operations; it requires and specifically authorizes implementing documents (e.g., manuals). It has also proven instrumental in the budgeting and planning process, most particularly in expediting the preparation of specific budgets and detailed schedules for each of the numerous work packages. The OPP is also used to communicate information about WIPP operations

  20. Operating systems for industrial robot controls

    Energy Technology Data Exchange (ETDEWEB)

    Ruck, J.; Rettelbusch, L.

    1982-01-01

    The authors explain the basic principles for the construction of the core of an operating system, the core being dependent upon the hardware but independent of the problem software. The operating system is designed upon four planes: the central hardware, the surrounding operating system core, the system program, and the user program. The tasks of the operating system core (responsibility for fast reaction to external events, process coordination and synchronization, amounting to simulation of a virtual machine for each process), are discussed in detail. The system permits the management of parallel-running or simultaneous processes so that every programmer working on the whole system can utilize his own virtual machine. 3 references.

  1. Facility design, construction, and operation

    International Nuclear Information System (INIS)

    1995-04-01

    France has been disposing of low-level radioactive waste (LLW) at the Centre de Stockage de la Manche (CSM) since 1969 and now at the Centre de Stockage de l'Aube (CSA) since 1992. In France, several agencies and companies are involved in the development and implementation of LLW technology. The Commissariat a l'Energie Atomic (CEA), is responsible for research and development of new technologies. The Agence National pour la Gestion des Dechets Radioactifs is the agency responsible for the construction and operation of disposal facilities and for wastes acceptance for these facilities. Compagnie Generale des Matieres Nucleaires provides fuel services, including uranium enrichment, fuel fabrication, and fuel reprocessing, and is thus one generator of LLW. Societe pour les Techniques Nouvelles is an engineering company responsible for commercializing CEA waste management technology and for engineering and design support for the facilities. Numatec, Inc. is a US company representing these French companies and agencies in the US. In Task 1.1 of Numatec's contract with Martin Marietta Energy Systems, Numatec provides details on the design, construction and operation of the LLW disposal facilities at CSM and CSA. Lessons learned from operation of CSM and incorporated into the design, construction and operating procedures at CSA are identified and discussed. The process used by the French for identification, selection, and evaluation of disposal technologies is provided. Specifically, the decisionmaking process resulting in the change in disposal facility design for the CSA versus the CSM is discussed. This report provides' all of the basic information in these areas and reflects actual experience to date

  2. Facility design, construction, and operation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    France has been disposing of low-level radioactive waste (LLW) at the Centre de Stockage de la Manche (CSM) since 1969 and now at the Centre de Stockage de l`Aube (CSA) since 1992. In France, several agencies and companies are involved in the development and implementation of LLW technology. The Commissariat a l`Energie Atomic (CEA), is responsible for research and development of new technologies. The Agence National pour la Gestion des Dechets Radioactifs is the agency responsible for the construction and operation of disposal facilities and for wastes acceptance for these facilities. Compagnie Generale des Matieres Nucleaires provides fuel services, including uranium enrichment, fuel fabrication, and fuel reprocessing, and is thus one generator of LLW. Societe pour les Techniques Nouvelles is an engineering company responsible for commercializing CEA waste management technology and for engineering and design support for the facilities. Numatec, Inc. is a US company representing these French companies and agencies in the US. In Task 1.1 of Numatec`s contract with Martin Marietta Energy Systems, Numatec provides details on the design, construction and operation of the LLW disposal facilities at CSM and CSA. Lessons learned from operation of CSM and incorporated into the design, construction and operating procedures at CSA are identified and discussed. The process used by the French for identification, selection, and evaluation of disposal technologies is provided. Specifically, the decisionmaking process resulting in the change in disposal facility design for the CSA versus the CSM is discussed. This report provides` all of the basic information in these areas and reflects actual experience to date.

  3. Ranking Operations Management conferences

    NARCIS (Netherlands)

    Steenhuis, H.J.; de Bruijn, E.J.; Gupta, Sushil; Laptaned, U

    2007-01-01

    Several publications have appeared in the field of Operations Management which rank Operations Management related journals. Several ranking systems exist for journals based on , for example, perceived relevance and quality, citation, and author affiliation. Many academics also publish at conferences

  4. Boiler operator's handbook

    CERN Document Server

    Heselton, Ken

    2004-01-01

    Containing key information for operators and managers of large and small plants, this is an indispensable guide for those at advanced and early stages of their careers, as well as for managers interested in reducing operating expenses.

  5. Autonomous Systems and Operations

    Data.gov (United States)

    National Aeronautics and Space Administration — The AES Autonomous Systems and Operations (ASO) project will develop an understanding of the impacts of increasing communication time delays on mission operations,...

  6. Vessel Operator System

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Operator cards are required for any operator of a charter/party boat and or a commercial vessel (including carrier and processor vessels) issued a vessel permit from...

  7. Spectrum of Class Operators

    Directory of Open Access Journals (Sweden)

    Yuan Jiangtao

    2007-01-01

    Full Text Available This paper discusses some spectral properties of class operators for , , , and . It is shown that if is a class operator, then the Riesz idempotent of with respect to each nonzero isolated point spectrum is selfadjoint and . Afterwards, we prove that every class operator has SVEP and property , and Weyl's theorem holds for when .

  8. Convolution Operators on Groups

    CERN Document Server

    Derighetti, Antoine

    2011-01-01

    This volume is devoted to a systematic study of the Banach algebra of the convolution operators of a locally compact group. Inspired by classical Fourier analysis we consider operators on Lp spaces, arriving at a description of these operators and Lp versions of the theorems of Wiener and Kaplansky-Helson.

  9. On the operator equivalents

    International Nuclear Information System (INIS)

    Grenet, G.; Kibler, M.

    1978-06-01

    A closed polynomial formula for the qth component of the diagonal operator equivalent of order k is derived in terms of angular momentum operators. The interest in various fields of molecular and solid state physics of using such a formula in connection with symmetry adapted operator equivalents is outlined

  10. Status of TRISTAN operation

    International Nuclear Information System (INIS)

    Satoh, Kotaro

    1990-01-01

    The present status of the TRISTAN operation is summarized mainly after the installation of superconducting cavities in the 1988 summer shutdown. The paper describes the initial experience of the superconducting cavity operation, the colliding operation at 30.4 GeV and the beam injection. Future improvement is also reported. (author)

  11. Operations and maintenance philosophy

    International Nuclear Information System (INIS)

    DUNCAN, G.P.

    1999-01-01

    This Operations and Maintenance (O and M) Philosophy document is intended to establish a future O and M vision, with an increased focus on minimizing worker exposure, ensuring uninterrupted retrieval operations, and minimizing operation life-cycle cost. It is intended that this document would incorporate O and M lessons learned into on-going and future project upgrades

  12. Safety aspects and operating experience of LWR plants in Japan

    International Nuclear Information System (INIS)

    Aoki, S.; Hinoki, M.

    1977-01-01

    From the outset of nuclear power development in Japan, major emphasis has been placed on the safety of the nuclear power plants. There are now twelve nuclear power plants in operation with a total output of 6600 MWe. Their operating records were generally satisfactory, but in the 1974 to 1975 period, they experienced somewhat declined availability due to the repair work under the specific circumstances. After investigation of causes of troubles and the countermeasures thereof were made to ensure safety, they are now keeping good performance. In Japan, nuclear power plants are strictly subject to sufficient and careful inspection in compliance with the safety regulation, and are placed under stringent radiation control of employees. Under the various circumstances, however, the period of annual inspection tends to be prolonged more than originally planned, and this consequently is considered to be one of the causes of reduced availability. In order to develop nuclear power generation for the future, it is necessary to put further emphasis on the assurance of safety and to endeavor to devise measures to improve availability of the plants, based on the careful analysis of causes which reduce plant availability. This paper discusses the results of studies made for the following items from such viewpoints: (1) Safety and Operating Experience of LWR Nuclear Power Plants in Japan; a) Operating experience with light water reactors b) Improvements in design of light water reactors during the past ten years c) Analysis of the factors which affect plant availability; 2) Assurance of Safety and Measures to Increase Availability a) Measures for safety and environmental protection b) Measures to reduce radiation exposure of employees c) Appropriateness of maintenance and inspection work d) Measures to increase plant availability e) Measures to improve reliability of equipments and components; and 3) Future Technical Problems

  13. British Columbia Power Export Corporation: Operational review for operating year, October 1989 to September 1990

    International Nuclear Information System (INIS)

    1990-01-01

    The British Columbia Power Export Corporation (POWEREX) is a wholly owned subsidiary of British Columbia Hydro, established in 1988 as the single agency responsible for implementing the provincial policy of international electricity trade. POWEREX objectives are to conduct long term firm electricity trade utilizing private sector financing, operating capabilities, and generating sources. Short term electricity transactions are handled by the part of POWEREX called the Powerex Pool Operation. An operational review of POWEREX for 1989-90 is presented, giving information on export contracts, license approvals, export sales negotiations, pool operation revenues and sales, British Columbia Hydro generation and integrated system performance, and operational planning. 15 figs

  14. Assessment of mucosal inflammation and blood flow in response to four weeks' intervention with probiotics in patients operated with a J-configurated ileal-pouch-anal-anastomosis (IPAA).

    Science.gov (United States)

    Laake, K O; Line, P D; Grzyb, K; Aamodt, G; Aabakken, L; Røset, A; Hvinden, A B; Bakka, A; Eide, J; Bjørneklett, A; Vatn, M H

    2004-12-01

    Pouchitis is a common and troublesome condition in patients operated on with ileal-pouch-anal-anastomosis (IPAA). A disturbed mucosal perfusion in the pouch has been suggested as a possible cause. Laser Doppler flowmetry (LDF) has been used successfully to measure gastric and colonic mucosal perfusion in humans. In a previous study, we demonstrated a reduced mucosal perfusion in the distal part of the pouch, during probiotic intervention, examined by LDF measurement. The aim of the present study was to confirm our previous results in a much larger material, and to compare the results of LDF measurements and inflammatory activity in ulcerative colitis (UC) patients with those in familial adenomatous polyposis (FAP) patients. Five hundred millilitres of a fermented milk product (Cultura), containing live lactobacilli (La-5) and bifidobacteria (Bb-12), was given daily for 4 weeks to 41 UC and 10 patients with FAP, operated on with IPAA. Mucosal perfusion was measured with LDF and the degree of inflammation was examined at predefined levels of the distal bowel by histology and faecal calprotectin measurements both before and after intervention. We also evaluated the applicability of a Pouchitis Disease Activity Index (PDAI). The LDF measurements were reproducible in the pelvic pouch at each of the predefined levels, but did not change during intervention. Mucosal perfusion was significantly reduced in the distal compared to the proximal part of the pouch in the UC group (P < 0.05). The perfusion levels were higher in the FAP patients compared to the UC patientsat all predefined levels (P < 0.05). Calprotectin levels and histological score did not change significantlyafter intervention in any of the groups. The calprotectin level was significantly lower in the FAP compared to the UC group both before and after intervention. The PDAI decreased in both groups from alevel considered diagnostic for pouchitis to a level considered as not active pouchitis. The decreasewas

  15. Measurement of dose equivalent with personal dosemeters and instrumentation of radiological protection in the new operative magnitudes ICRU, for external fields of radiation beta. Part IV. Survey of the angular response of instruments used in radiological protection in secondary patron fields of beta radiation (90Sr/90Y (1850 MBq and 74 MBq), 204TI (18.5 MBq) and 147Pm (518 MBq)

    International Nuclear Information System (INIS)

    Alvarez R, J.T.

    1994-02-01

    Tests type were made (type test) in the following commercial instrumentation commonly used in radiological protection: Geiger-Mueller Counters (FH40 FE), Plastic Scintillators (NE-BP/6/4A), Ionization Chambers (RO-5) and Proportional Counters (HP-100A; gas:P-10). With object of checking the possibility that these they can carry out the new operative unit ICRU, H' (0.07; α). The tests consisted on determining the energy and angular response of the detectors in secondary patron fields of beta radiation, for isotopes of 90 Sr/ 90 Y (1850 MBq and 74 MBq and 147 Pm(518 MBq). The results show the inadequate of these commercial instruments for the realization of the H' operative unit (0.07; α) in beta external fields. Due to flaws in the design, construction and calibration of the instruments for this type of radiation fields (Author)

  16. Operational symmetries basic operations in physics

    CERN Document Server

    Saller, Heinrich

    2017-01-01

    This book describes the endeavour to relate the particle spectrum with representations of operational electroweak spacetime, in analogy to the atomic spectrum as characterizing representations of hyperbolic space. The spectrum of hyperbolic position space explains the properties of the nonrelativistic atoms; the spectrum of electroweak spacetime is hoped to explain those of the basic interactions and elementary particles. In this book, the theory of operational symmetries is developed from the numbers, from Plato’s and Kepler’s symmetries over the simple Lie groups to their applications in nonrelativistic, special relativistic and general relativistic quantum theories with the atomic spectrum for hyperbolic position and, in first attempts, the particle spectrum for electroweak spacetime. The standard model of elementary particles and interactions is characterized by a symmetry group. In general, as initiated by Weyl and stressed by Heisenberg, quantum theory can be built as a theory of operation groups an...

  17. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1993-01-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes

  18. Site Response Analysis Using DeepSoil: Case Study of Bangka Site, Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    Iswanto, Eko Rudi; Yee, Eric [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2015-10-15

    Indonesia government declared through Act No. 17 year 2007 on the National Long-Term Development Plant Year 2005-2025 and Presidential Decree No. 5 year 2006 on the National Energy Policy (Indonesia 2007; Indonesia 2006), that nuclear energy is stated as a part of the national energy system. In order to undertake the above national policy, National Nuclear Energy Agency of Indonesia, as the promotor for the utilization of nuclear energy will conduct site study, which is a part of infrastructure preparation for NPP construction. Thorough preparation and steps are needed to operate an NPP and it takes between 10 to 15 years from the preliminary study (site selection, financial study, etc.) up to project implementation (manufacturing, construction, commissioning). During project implementation, it is necessary to prepare various documents relevant for permit application such as Safety Evaluation Report for site permit, Preliminary Safety Analysis Report and Environment Impact Assessment Report for construction permit. Considering the continuously increasing electricity energy demand, it is necessary to prepare for alternative NPP sites. The safety requirements of NPP's are stringent; amongst the various requirements is the ability to safely shut down in the wake of a possible earthquake. Ground response analysis of a potential site therefore needs to be carried out, parameter that affect the resistance of an NPP to earthquakes such as peak strain profiles is analysed. The objective of this paper is to analyse the ground response of the selected site for a NPP, using The Mw 7.9 in Sikuai Island, West Sumatra on September 12, 2007 as present input motion. This analysis will be carried out using a ground response analysis program, DeepSoil. In addition to this, an attempt was made to define the site specific input motion characteristics of the selected site for use in DeepSoil (DeepSoil 5.0). A site investigation at the WB site was performed primarily on the PS

  19. Operator Lipschitz functions

    Science.gov (United States)

    Aleksandrov, A. B.; Peller, V. V.

    2016-08-01

    The goal of this survey is a comprehensive study of operator Lipschitz functions. A continuous function f on the real line {R} is said to be operator Lipschitz if \\Vert f(A)-f(B)\\Vert≤slant{const}\\Vert A-B\\Vert for arbitrary self-adjoint operators A and B. Sufficient conditions and necessary conditions are given for operator Lipschitzness. The class of operator differentiable functions on {R} is also studied. Further, operator Lipschitz functions on closed subsets of the plane are considered, and the class of commutator Lipschitz functions on such subsets is introduced. An important role for the study of such classes of functions is played by double operator integrals and Schur multipliers. Bibliography: 77 titles.

  20. EL RIESGO DE RESPONSABILIDAD DEL ORGANO DE ADMINISTRACIÓN DE LAS COOPERATIVAS EN SITUACIONES DE INSOLVENCIA, Y DE PÉRDIDAS PATRIMONIALES/THE RISK OF RESPONSIBILITY FOR CO-OPERATIVES ADMINISTRATION ORGAN IN INSOLVENCY SITUATIONS, AND PATRIMONY LOSSES

    Directory of Open Access Journals (Sweden)

    Fernando SACRISTAN BERGIA

    2006-05-01

    Full Text Available En el presente trabajo se aborda el estudio de la responsabilidad de los administradores de las cooperativas en situaciones de pérdidas patrimoniales y de insolvencia. El estudio trata de presentar cual es el régimen legal de la responsabilidad en la actualidad, para lo que resulta necesario tener en cuenta el diferente tratamiento de la cuestión en función de las distintas leyes cooperativas autonómicas. El estudio toma en consideración el tratamiento jurisprudencial, que nos permite valorar la trascendencia práctica del tema y conocer la interpretación de los tribunales a las recientes reformas en materia de responsabilidad de los administradores. El régimen de responsabilidad previsto en la nueva Ley Concursal es objeto de tratamiento diferenciado en el último apartado./The current paper covers the aspect of the cooperative company´s directors legal responsability in situations of patrimonial losses and insolvency. The Study tries to present wich is the current Law, for what truns out to be necesary bear in mind the different treatment on the different cooperative autonomic laws. The study takes in consideration the jurisprudential treatment, wich allows us to value the practical transcendency of the interpretation which is the Court to the recentt reforms. The responsability in the Insolvency Law is an object of tratment differentiated in the last paragraph.

  1. A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Stress Disorder

    OpenAIRE

    James Douglas Bremner; James Douglas Bremner; James Douglas Bremner; James Douglas Bremner; James Douglas Bremner; Sanskriti Mishra; Carolina Campanella; Majid Shah; Nicole Kasher; Sarah Evans; Negar Fani; Amit Jasvant Shah; Amit Jasvant Shah; Collin Reiff; Lori L. Davis

    2017-01-01

    ObjectiveBrain imaging studies in patients with post-traumatic stress disorder (PTSD) have implicated a circuitry of brain regions including the medial prefrontal cortex, amygdala, hippocampus, parietal cortex, and insula. Pharmacological treatment studies have shown a reversal of medial prefrontal deficits in response to traumatic reminders. Mindfulness-based stress reduction (MBSR) is a promising non-pharmacologic approach to the treatment of anxiety and pain disorders. The purpose of this ...

  2. Operational radiation protection: A guide to optimization

    International Nuclear Information System (INIS)

    1990-01-01

    The purpose of this publication is to provide practical guidance on the application of the dose limitation system contained in the Basic Safety Standards for Radiation Protection to operational situations both in large nuclear installations and in much smaller facilities. It is anticipated that this Guide will be useful to both the management and radiation protection staff of operations in which there is a potential for occupational radiation exposures and to the competent authorities with responsibilities for providing a programme of regulatory control. Contents: Dose limitation system; Optimization and its practical application to operational radiation protection; Major elements of an effective operational radiation protection programme; Review of selected parts of the basic safety standards with special reference to operational radiation protection; Optimization of radiation protection; Techniques for the systematic appraisal of operational radiation protection programmes. Refs and figs

  3. Texture classification using logical operators.

    Science.gov (United States)

    Manian, V; Vasquez, R; Katiyar, P

    2000-01-01

    In this paper, a new algorithm for texture classification based on logical operators is presented. Operators constructed from logical building blocks are convolved with texture images. An optimal set of six operators are selected based on their texture discrimination ability. The responses are then converted to standard deviation matrices computed over a sliding window. Zonal sampling features are computed from these matrices. A feature selection process is applied and the new set of features are used for texture classification. Classification of several natural and synthetic texture images are presented demonstrating the excellent performance of the logical operator method. The computational superiority and classification accuracy of the algorithm is demonstrated by comparison with other popular methods. Experiments with different classifiers and feature normalization are also presented. The Euclidean distance classifier is found to perform best with this algorithm. The algorithm involves only convolutions and simple arithmetic in the various stages which allows faster implementations. The algorithm is applicable to different types of classification problems which is demonstrated by segmentation of remote sensing images, compressed and reconstructed images and industrial images.

  4. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Trauma Operative Management Basic Endovascular Skills for Trauma Disaster Management and Emergency Preparedness Rural Trauma Team Development ... 202-5001 (E) postmaster@facs.org Copyright © 1996-2018 by the American College of Surgeons, Chicago, IL ...

  5. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... and Videos Hotel and Travel Clinical Congress 2017 Future Clinical Congresses MyCME About MyCME About MyCME Claim ... Surgical Skills for Exposure in Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills ...

  6. Your Lung Operation: After Your Operation

    Medline Plus

    Full Text Available ... Contact My Profile Shop ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Your Lung Operation ... facs.org Copyright © 1996-2018 by the American College of Surgeons, Chicago, IL 60611-3295 | Privacy Policy | Terms of Use

  7. Public Comments on the proposed 10 CFR Part 51 rule for renewal of nuclear power plant operating licenses and supporting documents: Review of concerns and NRC staff response. Appendices

    International Nuclear Information System (INIS)

    1996-05-01

    This volume contains several appendices. Appendix A contains the list of individuals and organizations providing comments at various stages of the rulemaking process. The names of commenters at the public meetings are listed in the order that they spoke at the meeting; those who submitted written comments are listed by docket number. Appendix B contains the summaries of comments made. Each comment summary is identified by a unique comment number. Appendix C presents the concerns and NRC staff responses. Each concern embodies one or more comments on similar or related issues. The associated comment numbers are referenced for each concern. The concerns are organized by topic areas. A three-letter identifier for the topic, followed by a number, is assigned to each concern

  8. Public Comments on the proposed 10 CFR Part 51 rule for renewal of nuclear power plant operating licenses and supporting documents: Review of concerns and NRC staff response. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    This volume contains several appendices. Appendix A contains the list of individuals and organizations providing comments at various stages of the rulemaking process. The names of commenters at the public meetings are listed in the order that they spoke at the meeting; those who submitted written comments are listed by docket number. Appendix B contains the summaries of comments made. Each comment summary is identified by a unique comment number. Appendix C presents the concerns and NRC staff responses. Each concern embodies one or more comments on similar or related issues. The associated comment numbers are referenced for each concern. The concerns are organized by topic areas. A three-letter identifier for the topic, followed by a number, is assigned to each concern.

  9. Hermeneutic operative calculus

    Science.gov (United States)

    Ramakrishnan, Sivakumar; Isawasan, Pradeep; Mohanan, Vasuky

    2014-07-01

    The predicate calculus used currently by mathematical logic in computer science, philosophy and linguistic was found to be too restrictive and inadequate for describing the grammar of natural and artificial language. Therefore many higher order logics have been developed to overcome the limitation of predicate calculus. In this paper a new representation of logic using mathematical principles has been developed for the natural language called Hermeneutic Operative Calculus. This Hermeneutic Operative Calculus is a new language interpretive calculus developed to account for the syntactic, semantic and pragmatic features of natural language and allows removing the restrictions of any particular natural language in the semantic field its map out. The logic of Hermeneutic Operative Calculus capable of represent the syntactic and semantic of factual information of a natural language precisely in any language. The logic of this Hermeneutic Operative Calculus has two different forms of operations called object and meta-operations. The object operation allow for listing the various objects, picturing the various propositions and so forth. The meta-operation would specify what cannot be specified by the object operation like semantical stances of a proposition. The basic operative processes of linguistics and cognitive logic will be mathematically conceptualized and elaborated in this paper.

  10. Supporting the operational use of process based hydrological models and NASA Earth Observations for use in land management and post-fire remediation through a Rapid Response Erosion Database (RRED).

    Science.gov (United States)

    Miller, M. E.; Elliot, W.; Billmire, M.; Robichaud, P. R.; Banach, D. M.

    2017-12-01

    We have built a Rapid Response Erosion Database (RRED, http://rred.mtri.org/rred/) for the continental United States to allow land managers to access properly formatted spatial model inputs for the Water Erosion Prediction Project (WEPP). Spatially-explicit process-based models like WEPP require spatial inputs that include digital elevation models (DEMs), soil, climate and land cover. The online database delivers either a 10m or 30m USGS DEM, land cover derived from the Landfire project, and soil data derived from SSURGO and STATSGO datasets. The spatial layers are projected into UTM coordinates and pre-registered for modeling. WEPP soil parameter files are also created along with linkage files to match both spatial land cover and soils data with the appropriate WEPP parameter files. Our goal is to make process-based models more accessible by preparing spatial inputs ahead of time allowing modelers to focus on addressing scenarios of concern. The database provides comprehensive support for post-fire hydrological modeling by allowing users to upload spatial soil burn severity maps, and within moments returns spatial model inputs. Rapid response is critical following natural disasters. After moderate and high severity wildfires, flooding, erosion, and debris flows are a major threat to life, property and municipal water supplies. Mitigation measures must be rapidly implemented if they are to be effective, but they are expensive and cannot be applied everywhere. Fire, runoff, and erosion risks also are highly heterogeneous in space, creating an urgent need for rapid, spatially-explicit assessment. The database has been used to help assess and plan remediation on over a dozen wildfires in the Western US. Future plans include expanding spatial coverage, improving model input data and supporting additional models. Our goal is to facilitate the use of the best possible datasets and models to support the conservation of soil and water.

  11. Operational options for green ships

    Science.gov (United States)

    Sherbaz, Salma; Duan, Wenyang

    2012-09-01

    Environmental issues and rising fuel prices necessitate better energy-efficiency in all sectors. The shipping industry is one of the major stakeholders, responsible for 3% of global CO2 emissions, 14%-15% of global NO X emissions, and 16% of global SO X emissions. In addition, continuously rising fuel prices are also an incentive to focus on new ways for better energy-effectiveness. The green ship concept requires exploring and implementing technology on ships to increase energy-efficiency and reduce emissions. Ship operation is an important topic with large potential to increase cost-and-energy-effectiveness. This paper provided a comprehensive review of basic concepts, principles, and potential of operational options for green ships. The key challenges pertaining to ship crew i.e. academic qualifications prior to induction, in-service training and motivation were discussed. The author also deliberated on remedies to these challenges.

  12. Radioactive materials transportation emergency response plan

    International Nuclear Information System (INIS)

    Karmali, N.

    1987-05-01

    Ontario Hydro transports radioactive material between its nuclear facilities, Atomic Energy of Canada Limited at Chalk River Laboratories and Radiochemical Company in Kanata, on a regular basis. Ontario Hydro also occasionally transports to Whiteshell Laboratories, Hydro-Quebec and New Brunswick Electric Power Commission. Although there are stringent packaging and procedural requirements for these shipments, Ontario Hydro has developed a Radioactive Materials Transportation Emergency Response Plan in the event that there is an accident. The Transportation Emergency Response plan is based on six concepts: 1) the Province id divided into three response areas with each station (Pickering, Darlington, Bruce) having identified response areas; 2) response is activated via a toll-free number. A shift supervisor at Pickering will answer the call, determine the hazards involved from the central shipment log and provide on-line advice to the emergency worker. At the same time he will notify the nearest Ontario Hydro area office to provide initial corporate response, and will request the nearest nuclear station to provide response assistance; 3) all stations have capability in terms of trained personnel and equipment to respond to an accident; 4) all Ontario Hydro shipments are logged with Pickering NGS. Present capability is based on computerized logging with the computer located in the shift office at Pickering to allow quick access to information on the shipment; 5) there is a three tier structure for emergency public information. The local Area Manager is the first Ontario Hydro person at the scene of the accident. The responding facility technical spokesperson is the second line of Corporate presence and the Ontario Hydro Corporate spokesperson is notified in case the accident is a media event; and 6) Ontario Hydro will respond to non-Hydro shipments of radioactive materials in terms of providing assistance, guidance and capability. However, the shipper is responsible

  13. Personal responsibility or shared responsibility: What is the appropriate role of the law in obesity prevention?

    Science.gov (United States)

    Brooks, Benjamin

    2015-09-01

    Sensitive to allegations of "nanny state" paternalism, Australian governments support the doctrine that combating obesity is a matter of personal responsibility. Policy-makers endorse the "holistic" approach to obesity prevention, with a view to managing both sides of the nutritional energy equation. This paradigm allows the food and drinks industry to deflect its contributory responsibility for the epidemic and to avoid more stringent regulatory intervention beyond existing self-regulatory and corporate social responsibility regimes. This article argues that the industry must bear shared responsibility for the extent of the obesity crisis, although it cannot bear sole responsibility It defends the public interest case for more invasive, government-led regulation, reframing the crisis as one of public not individual burdens. Mindful of the political risk associated with unfocused calls for regulatory intervention, it articulates a set of regulatory principles to ensure that the interests of consumers and industry are properly acknowledged prior to further regulatory intervention. Finally, the article clarifies the subject, object and content of possible regulatory initiatives, offering an evaluation of their efficacy, practicality and fairness.

  14. Contextual control of discriminated operant behavior.

    Science.gov (United States)

    Bouton, Mark E; Todd, Travis P; León, Samuel P

    2014-01-01

    Previous research has suggested that changing the context after instrumental (operant) conditioning can weaken the strength of the operant response. That result contrasts with the results of studies of Pavlovian conditioning, in which a context switch often does not affect the response elicited by a conditioned stimulus. To begin to make the methods more similar, Experiments 1-3 tested the effects of a context switch in rats on a discriminated operant response (R; lever pressing or chain pulling) that had been reinforced only in the presence of a 30-s discriminative stimulus (S; tone or light). As in Pavlovian conditioning, responses and reinforcers became confined to presentations of the S during training. However, in Experiment 1, after training in Context A, a switch to Context B caused a decrement in responding during S. In Experiment 2, a switch to Context B likewise decreased responding in S when Context B was equally familiar, equally associated with reinforcement, or equally associated with the training of a discriminated operant (a different R reinforced in a different S). However, there was no decrement if Context B had been associated with the same response that was trained in Context A (Experiments 2 and 3). The effectiveness of S transferred across contexts, whereas the strength of the response did not. Experiment 4 found that a continuously reinforced response was also disrupted by context change when the same response manipulandum was used in both training and testing. Overall, the results suggest that the context can have a robust general role in the control of operant behavior. Mechanisms of contextual control are discussed.

  15. Fault Management Techniques in Human Spaceflight Operations

    Science.gov (United States)

    O'Hagan, Brian; Crocker, Alan

    2006-01-01

    This paper discusses human spaceflight fault management operations. Fault detection and response capabilities available in current US human spaceflight programs Space Shuttle and International Space Station are described while emphasizing system design impacts on operational techniques and constraints. Preflight and inflight processes along with products used to anticipate, mitigate and respond to failures are introduced. Examples of operational products used to support failure responses are presented. Possible improvements in the state of the art, as well as prioritization and success criteria for their implementation are proposed. This paper describes how the architecture of a command and control system impacts operations in areas such as the required fault response times, automated vs. manual fault responses, use of workarounds, etc. The architecture includes the use of redundancy at the system and software function level, software capabilities, use of intelligent or autonomous systems, number and severity of software defects, etc. This in turn drives which Caution and Warning (C&W) events should be annunciated, C&W event classification, operator display designs, crew training, flight control team training, and procedure development. Other factors impacting operations are the complexity of a system, skills needed to understand and operate a system, and the use of commonality vs. optimized solutions for software and responses. Fault detection, annunciation, safing responses, and recovery capabilities are explored using real examples to uncover underlying philosophies and constraints. These factors directly impact operations in that the crew and flight control team need to understand what happened, why it happened, what the system is doing, and what, if any, corrective actions they need to perform. If a fault results in multiple C&W events, or if several faults occur simultaneously, the root cause(s) of the fault(s), as well as their vehicle-wide impacts, must be

  16. Global Operations Networks

    DEFF Research Database (Denmark)

    closely working with, and which are best suited to illuminate a particular aspect of organising and managing global operations in networks. The book addresses the following broadly defined themes: • Contexts of global operations networks, • Configurations of global operations networks, • Capabilities......, international comparative studies providing comprehensive insights from it are still rare. With the objective of bridging this gap, Global Operations Networks (GONE) project (sponsored by the Danish Research Council) brought together numerous academic and industrial partners from Denmark, Sweden and Finland...... of global operations and operations strategy. This summative volume utilises the rich and diverse empirical foundation generated during the project activities in Denmark, Sweden and Finland. Chapters of the book are based on quantitative data and multiple case studies which the project partners have been...

  17. Operations management system

    Science.gov (United States)

    Brandli, A. E.; Eckelkamp, R. E.; Kelly, C. M.; Mccandless, W.; Rue, D. L.

    1990-01-01

    The objective of an operations management system is to provide an orderly and efficient method to operate and maintain aerospace vehicles. Concepts are described for an operations management system and the key technologies are highlighted which will be required if this capability is brought to fruition. Without this automation and decision aiding capability, the growing complexity of avionics will result in an unmanageable workload for the operator, ultimately threatening mission success or survivability of the aircraft or space system. The key technologies include expert system application to operational tasks such as replanning, equipment diagnostics and checkout, global system management, and advanced man machine interfaces. The economical development of operations management systems, which are largely software, will require advancements in other technological areas such as software engineering and computer hardware.

  18. Corporate Responsibility

    DEFF Research Database (Denmark)

    Waddock, Sandra; Rasche, Andreas

    2015-01-01

    We define and discuss the concept of corporate responsibility. We suggest that corporate responsibility has some unique characteristics, which makes it different from earlier conceptions of corporate social responsibility. Our discussion further shows commonalities and differences between corporate...... responsibility and related concepts, such as corporate citizenship and business ethics. We also outline some ways in which corporations have implemented corporate responsibility in practice....

  19. Purge ventilation operability

    International Nuclear Information System (INIS)

    Marella, J.R.

    1995-01-01

    A determination of minimum requirements for purge exhaust ventilation system operability has been performed. HLWE and HLW Regulatory Program personnel have evaluated the various scenarios of equipment conditions and HLWE has developed the requirements for purge exhaust systems. This report is provided to document operability requirements to assist Tank Farm personnel to determine whether a system is operable/inoperable and to define required compensatory actions

  20. Cyberwarfare and Operational Art

    Science.gov (United States)

    2017-05-25

    warfare within the framework of operational art. The case study evaluated the Russian Federation cyber operations in time and space to support a theory ...case study evaluated the Russian Federation cyber operations in time and space to support a theory that cyber and land force actions can transform...1 Cyberspace manifested on March 18, 1940, when Alan Turing developed the "electromechanical mind ." Turing along with others at Bletchley Park