A plane stress softening plasticity model for orthotropic materials

NARCIS (Netherlands)

Lourenço, P.B.; Borst, R. de; Rots, J.G.

1997-01-01

A plane stress model has been developed for quasi-brittle orthotropic materials. The theory of plasticity, which is adopted to describe the inelastic behaviour, utilizes modern algorithmic concepts, including an implicit Euler backward return mapping scheme, a local Newton-Raphson method and a

Effects of chronic stress on the brain – the evidence from morphological examinations of hippocampus in a chronic unpredictable stress (CUS model in rats

Directory of Open Access Journals (Sweden)

Joanna Sekita-Krzak

2016-12-01

    Abstract Background. Chronic stress exposure deteriorates memory and increases the risk of psychiatric disorders, including depression. Objectives. The objective of this study was to perform morphological studies in experimental model of neuropsychiatric disorder and to assess histologically the effect of chronic unpredictable stress procedure (CUS influence on hippocampus. Material and methods. Chronic unpredictable stress procedure (CUS was applied for 8 weeks in rats by the modified method described by Katz et al. Experimental model of neuropsychiatric disorder was used based on morphological studies of hippocampal formation. Results. Stress-induced alterations were observed in the hippocampus. Nerve cell changes included  neuron shrinkage and dendritic remodeling. The most vulnerable hippocampal cells to chronic stress were CA3 and CA4 pyramidal neurons. In dentate gyrus chronic stress led to granule neuron shrinkage and slight exacerbation of apoptosis in the polygonal cell layer. CUS led to statistically significant changes in quantitative characteristics of the CA3 and CA4 neuron size and nuclei diameter. Conclusions. Chronic stress induces degeneration of hippocampal neurons. The observed neuronal changes indicate the damage of the neurons did not involve neither apoptosis nor necrosis Similarity between histological changes obtained in 8-week long CUS procedure applied in our research and morphological changes described in depressed patients confirms the usefulness of the applied stress procedure as the experimental model of depression.   Key words: stress, depression, hippocampus, chronic unpredictable stress procedure (CUS, animal model, morphology.

Emotional Stress and Cardiovascular Complications in Animal Models: A Review of the Influence of Stress Type.

Science.gov (United States)

Crestani, Carlos C

2016-01-01

Emotional stress has been recognized as a modifiable risk factor for cardiovascular diseases. The impact of stress on physiological and psychological processes is determined by characteristics of the stress stimulus. For example, distinct responses are induced by acute vs. chronic aversive stimuli. Additionally, the magnitude of stress responses has been reported to be inversely related to the degree of predictability of the aversive stimulus. Therefore, the purpose of the present review was to discuss experimental research in animal models describing the influence of stressor stimulus characteristics, such as chronicity and predictability, in cardiovascular dysfunctions induced by emotional stress. Regarding chronicity, the importance of cardiovascular and autonomic adjustments during acute stress sessions and cardiovascular consequences of frequent stress response activation during repeated exposure to aversive threats (i.e., chronic stress) is discussed. Evidence of the cardiovascular and autonomic changes induced by chronic stressors involving daily exposure to the same stressor (predictable) vs. different stressors (unpredictable) is reviewed and discussed in terms of the impact of predictability in cardiovascular dysfunctions induced by stress.

STRESS INDUCED OBESITY: LESSONS FROM RODENT MODELS OF STRESS

Directory of Open Access Journals (Sweden)

Zachary Robert Patterson

2013-07-01

Full Text Available Stress is defined as the behavioral and physiological responses generated in the face of, or in anticipation of, a perceived threat. The stress response involves activation of the sympathetic nervous system and recruitment of the hypothalamic-pituitary-adrenal (HPA axis. When an organism encounters a stressor (social, physical, etc., these endogenous stress systems are stimulated in order to generate a fight-or-flight response, and manage the stressful situation. As such, an organism is forced to liberate energy resources in attempt to meet the energetic demands posed by the stressor. A change in the energy homeostatic balance is thus required to exploit an appropriate resource and deliver useable energy to the target muscles and tissues involved in the stress response. Acutely, this change in energy homeostasis and the liberation of energy is considered advantageous, as it is required for the survival of the organism. However, when an organism is subjected to a prolonged stressor, as is the case during chronic stress, a continuous irregularity in energy homeostasis is considered detrimental and may lead to the development of metabolic disturbances such as cardiovascular disease, type II diabetes mellitus and obesity. This concept has been studied extensively using animal models, and the neurobiological underpinnings of stress induced metabolic disorders are beginning to surface. However, different animal models of stress continue to produce divergent metabolic phenotypes wherein some animals become anorexic and loose body mass while others increase food intake and body mass and become vulnerable to the development of metabolic disturbances. It remains unclear exactly what factors associated with stress models can be used to predict the metabolic outcome of the organism. This review will explore a variety of rodent stress models and discuss the elements that influence the metabolic outcome in order to further our understanding of stress

Frameworks for understanding and describing business models

DEFF Research Database (Denmark)

Nielsen, Christian; Roslender, Robin

2014-01-01

This chapter provides in a chronological fashion an introduction to six frameworks that one can apply to describing, understanding and also potentially innovating business models. These six frameworks have been chosen carefully as they represent six very different perspectives on business models...... and in this manner “complement” each other. There are a multitude of varying frameworks that could be chosen from and we urge the reader to search and trial these for themselves. The six chosen models (year of release in parenthesis) are: • Service-Profit Chain (1994) • Strategic Systems Auditing (1997) • Strategy...... Maps (2001) • Intellectual Capital Statements (2003) • Chesbrough’s framework for Open Business Models (2006) • Business Model Canvas (2008)...

Statistical models describing the energy signature of buildings

DEFF Research Database (Denmark)

Bacher, Peder; Madsen, Henrik; Thavlov, Anders

2010-01-01

Approximately one third of the primary energy production in Denmark is used for heating in buildings. Therefore efforts to accurately describe and improve energy performance of the building mass are very important. For this purpose statistical models describing the energy signature of a building, i...... or varying energy prices. The paper will give an overview of statistical methods and applied models based on experiments carried out in FlexHouse, which is an experimental building in SYSLAB, Risø DTU. The models are of different complexity and can provide estimates of physical quantities such as UA......-values, time constants of the building, and other parameters related to the heat dynamics. A method for selecting the most appropriate model for a given building is outlined and finally a perspective of the applications is given. Aknowledgements to the Danish Energy Saving Trust and the Interreg IV ``Vind i...

Stress field modelling from digital geological map data

Science.gov (United States)

Albert, Gáspár; Barancsuk, Ádám; Szentpéteri, Krisztián

2016-04-01

To create a model for the lithospheric stress a functional geodatabase is required which contains spatial and geodynamic parameters. A digital structural-geological map is a geodatabase, which usually contains enough attributes to create a stress field model. Such a model is not accurate enough for engineering-geological purposes because simplifications are always present in a map, but in many cases maps are the only sources for a tectonic analysis. The here presented method is designed for field geologist, who are interested to see the possible realization of the stress field over the area, on which they are working. This study presents an application which can produce a map of 3D stress vectors from a kml-file. The core application logic is implemented on top of a spatially aware relational database management system. This allows rapid and geographically accurate analysis of the imported geological features, taking advantage of standardized spatial algorithms and indexing. After pre-processing the map features in a GIS, according to the Type-Property-Orientation naming system, which was described in a previous study (Albert et al. 2014), the first stage of the algorithm generates an irregularly spaced point cloud by emitting a pattern of points within a user-defined buffer zone around each feature. For each point generated, a component-wise approximation of the tensor field at the point's position is computed, derived from the original feature's geodynamic properties. In a second stage a weighted moving average method calculates the stress vectors in a regular grid. Results can be exported as geospatial data for further analysis or cartographic visualization. Computation of the tensor field's components is based on the implementation of the Mohr diagram of a compressional model, which uses a Coulomb fracture criterion. Using a general assumption that the main principal stress must be greater than the stress from the overburden, the differential stress is

Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress.

Science.gov (United States)

Perrine, Shane A; Eagle, Andrew L; George, Sophie A; Mulo, Kostika; Kohler, Robert J; Gerard, Justin; Harutyunyan, Arman; Hool, Steven M; Susick, Laura L; Schneider, Brandy L; Ghoddoussi, Farhad; Galloway, Matthew P; Liberzon, Israel; Conti, Alana C

2016-04-15

Appropriate animal models of posttraumatic stress disorder (PTSD) are needed because human studies remain limited in their ability to probe the underlying neurobiology of PTSD. Although the single prolonged stress (SPS) model is an established rat model of PTSD, the development of a similarly-validated mouse model emphasizes the benefits and cross-species utility of rodent PTSD models and offers unique methodological advantages to that of the rat. Therefore, the aims of this study were to develop and describe a SPS model for mice and to provide data that support current mechanisms relevant to PTSD. The mouse single prolonged stress (mSPS) paradigm, involves exposing C57Bl/6 mice to a series of severe, multimodal stressors, including 2h restraint, 10 min group forced swim, exposure to soiled rat bedding scent, and exposure to ether until unconsciousness. Following a 7-day undisturbed period, mice were tested for cue-induced fear behavior, effects of paroxetine on cue-induced fear behavior, extinction retention of a previously extinguished fear memory, dexamethasone suppression of corticosterone (CORT) response, dorsal hippocampal glucocorticoid receptor protein and mRNA expression, and prefrontal cortex glutamate levels. Exposure to mSPS enhanced cue-induced fear, which was attenuated by oral paroxetine treatment. mSPS also disrupted extinction retention, enhanced suppression of stress-induced CORT response, increased mRNA expression of dorsal hippocampal glucocorticoid receptors and decreased prefrontal cortex glutamate levels. These data suggest that the mSPS model is a translationally-relevant model for future PTSD research with strong face, construct, and predictive validity. In summary, mSPS models characteristics relevant to PTSD and this severe, multimodal stress modifies fear learning in mice that coincides with changes in the hypothalamo-pituitary-adrenal (HPA) axis, brain glucocorticoid systems, and glutamatergic signaling in the prefrontal cortex

Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder

Science.gov (United States)

Lisieski, Michael J.; Eagle, Andrew L.; Conti, Alana C.; Liberzon, Israel; Perrine, Shane A.

2018-01-01

Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric condition. However, the biological mechanisms underlying this disease are still largely unknown or poorly understood. Considerable evidence indicates that PTSD results from dysfunction in highly-conserved brain systems involved in stress, anxiety, fear, and reward. Pre-clinical models of traumatic stress exposure are critical in defining the neurobiological mechanisms of PTSD, which will ultimately aid in the development of new treatments for PTSD. Single prolonged stress (SPS) is a pre-clinical model that displays behavioral, molecular, and physiological alterations that recapitulate many of the same alterations observed in PTSD, illustrating its validity and giving it utility as a model for investigating post-traumatic adaptations and pre-trauma risk and protective factors. In this manuscript, we review the present state of research using the SPS model, with the goals of (1) describing the utility of the SPS model as a tool for investigating post-trauma adaptations, (2) relating findings using the SPS model to findings in patients with PTSD, and (3) indicating research gaps and strategies to address them in order to improve our understanding of the pathophysiology of PTSD. PMID:29867615

Development of residual stress prediction model in pipe weldment

Energy Technology Data Exchange (ETDEWEB)

Eom, Yun Yong; Lim, Se Young; Choi, Kang Hyeuk; Cho, Young Sam; Lim, Jae Hyuk [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

2002-03-15

When Leak Before Break(LBB) concepts is applied to high energy piping of nuclear power plants, residual weld stresses is a important variable. The main purpose of his research is to develop the numerical model which can predict residual weld stresses. Firstly, basic theories were described which need to numerical analysis of welding parts. Before the analysis of pipe, welding of a flat plate was analyzed and compared. Appling the data of used pipes, thermal/mechanical analysis were accomplished and computed temperature gradient and residual stress distribution. For thermal analysis, proper heat flux was regarded as the heat source and convection/radiation heat transfer were considered at surfaces. The residual stresses were counted from the computed temperature gradient and they were compared and verified with a result of another research.

To stress or not to stress: a question of models.

Science.gov (United States)

Gray, J Megan; Chaouloff, Francis; Hill, Matthew N

2015-01-05

Stress research is a rapidly evolving field that encompasses numerous disciplines ranging from neuroscience to metabolism. With many new researchers migrating into the field, navigating the hows and whys of specific research questions can sometimes be enigmatic given the availability of so many models in the stress field. Additionally, as with every field, there are many seemingly minor experimental details that can have dramatic influences on data interpretation, although many of these are unknown to those not familiar with the field. The aim of this overview is to provide some suggestions and points to guide researchers moving into the stress field and highlight relevant methodological points that they should consider when choosing a model for stress and deciding how to structure a study. We briefly provide a primer on the basics of endpoint measurements in the stress field, factors to consider when choosing a model for acute stress, the difference between repeated and chronic stress, and importantly, influencing variables that modulate endpoints of analysis in stress work. Copyright © 2015 John Wiley & Sons, Inc.

Stress-reducing preventive maintenance model for a unit under stressful environment

International Nuclear Information System (INIS)

Park, J.H.; Chang, Woojin; Lie, C.H.

2012-01-01

We develop a preventive maintenance (PM) model for a unit operated under stressful environment. The PM model in this paper consists of a failure rate model and two cost models to determine the optimal PM scheduling which minimizes a cost rate. The assumption for the proposed model is that stressful environment accelerates the failure of the unit and periodic maintenances reduce stress from outside. The failure rate model handles the maintenance effect of PM using improvement and stress factors. The cost models are categorized into two failure recognition cases: immediate failure recognition and periodic failure detection. The optimal PM scheduling is obtained by considering the trade-off between the related cost and the lifetime of a unit in our model setting. The practical usage of our proposed model is tested through a numerical example.

Stress description model by non destructive magnetic methods

International Nuclear Information System (INIS)

Flambard, C.; Grossiord, J.L.; Tourrenc, P.

1983-01-01

Since a few years, CETIM investigates analysis possibilities of materials, by developing a method founded on observation of ferromagnetic noise. By experiments, correlations have become obvious between state of the material and recorded signal. These correlations open to industrial applications to measure stresses and strains in elastic and plastic ranges. This article starts with a brief historical account and theoretical backgrounds of the method. The experimental frame of this research is described, and the main results are analyzed. Theoretically, a model was built up, and we present it. It seems in agreement with some experimental observations. The main results concerning stress application, thermal and surface treatments (decarbonizing) are presented [fr

Model and calculation of in situ stresses in anisotropic formations

Energy Technology Data Exchange (ETDEWEB)

Yuezhi, W.; Zijun, L.; Lixin, H. [Jianghan Petroleum Institute, (China)

1997-08-01

In situ stresses in transversely isotropic material in relation to wellbore stability have been investigated. Equations for three horizontal in- situ stresses and a new formation fracture pressure model were described, and the methodology for determining the elastic parameters of anisotropic rocks in the laboratory was outlined. Results indicate significantly smaller differences between theoretically calculated pressures and actual formation pressures than results obtained by using the isotropic method. Implications for improvements in drilling efficiency were reviewed. 13 refs., 6 figs.

The chronic mild stress (CMS) model of depression: History, evaluation and usage.

Science.gov (United States)

Willner, Paul

2017-02-01

Now 30 years old, the chronic mild stress (CMS) model of depression has been used in >1300 published studies, with a year-on-year increase rising to >200 papers in 2015. Data from a survey of users show that while a variety of names are in use (chronic mild/unpredictable/varied stress), these describe essentially the same procedure. This paper provides an update on the validity and reliability of the CMS model, and reviews recent data on the neurobiological basis of CMS effects and the mechanisms of antidepressant action: the volume of this research may be unique in providing a comprehensive account of antidepressant action within a single model. Also discussed is the use of CMS in drug discovery, with particular reference to hippocampal and extra-hippocampal targets. The high translational potential of the CMS model means that the neurobiological mechanisms described may be of particular relevance to human depression and mechanisms of clinical antidepressant action.

A coupled creep plasticity model for residual stress relaxation of a shot-peened nickel-based superalloy

Science.gov (United States)

Buchanan, Dennis J.; John, Reji; Brockman, Robert A.; Rosenberger, Andrew H.

2010-01-01

Shot peening is a commonly used surface treatment process that imparts compressive residual stresses into the surface of metal components. Compressive residual stresses retard initiation and growth of fatigue cracks. During component loading history, shot-peened residual stresses may change due to thermal exposure, creep, and cyclic loading. In these instances, taking full credit for compressive residual stresses would result in a nonconservative life prediction. This article describes a methodical approach for characterizing and modeling residual stress relaxation under elevated temperature loading, near and above the monotonic yield strength of INI 00. The model incorporates the dominant creep deformation mechanism, coupling between the creep and plasticity models, and effects of prior plastic strain to simulate surface treatment deformation.

Modelling anelastic contribution to nuclear fuel cladding creep and stress relaxation

Energy Technology Data Exchange (ETDEWEB)

Tulkki, Ville, E-mail: ville.tulkki@vtt.fi; Ikonen, Timo

2015-10-15

In fuel behaviour modelling accurate description of the cladding mechanical response is important for both operational and safety considerations. While accuracy is desired, a certain level of simplicity is needed as both computational resources and detailed information on properties of particular cladding may be limited. Most models currently used in the integral codes divide the mechanical response into elastic and viscoplastic contributions. These have difficulties in describing both creep and stress relaxation, and often separate models for the two phenomena are used. In this paper we implement anelastic contribution to the cladding mechanical model, thus enabling consistent modelling of both creep and stress relaxation. We show that the model based on assumption of viscoelastic behaviour can be used to explain several experimental observations in transient situations and compare the model to published set of creep and stress relaxation experiments performed on similar samples. Based on the analysis presented we argue that the inclusion of anelastic contribution to the cladding mechanical models provides a way to improve the simulation of cladding behaviour during operational transients.

Stress and deformation modeling of multiple rotary combustion engine trochoid housings

Science.gov (United States)

Lychuk, W. M.; Bradley, S. A.; Vilmann, C. R.; Passerello, C. E.; Lee, C.-M.

1986-01-01

This paper documents the development of the capability to produce finite element models of alternate trochoid housing configurations. The effort needed to produce these models is greatly reduced by the use of a newly developed specialized finite element preprocessor which is described. The results of static stress comparisons conducted on a Mazda trochoid housing are presented. Planned future development of this modeling capability to operational situations is also presented.

Ecohydrology in Mediterranean areas: a numerical model to describe growing seasons out of phase with precipitations

Directory of Open Access Journals (Sweden)

D. Pumo

2008-02-01

Full Text Available The probabilistic description of soil moisture dynamics is a relatively new topic in hydrology. The most common ecohydrological models start from a stochastic differential equation describing the soil water balance, where the unknown quantity, the soil moisture, depends both on spaces and time. Most of the solutions existing in literature are obtained in a probabilistic framework and under steady-state condition; even if this last condition allows the analytical handling of the problem, it has considerably simplified the same problem by subtracting generalities from it.

The steady-state hypothesis, appears perfectly applicable in arid and semiarid climatic areas like those of African's or middle American's savannas, but it seems to be no more valid in areas with Mediterranean climate, where, notoriously, the wet season foregoes the growing season, recharging water into the soil. This moisture stored at the beginning of the growing season (known as soil moisture initial condition has a great importance, especially for deep-rooted vegetation, by enabling survival in absence of rainfalls during the growing season and, however, keeping the water stress low during the first period of the same season.

The aim of this paper is to analyze the soil moisture dynamics using a simple non-steady numerical ecohydrological model. The numerical model here proposed is able to reproduce soil moisture probability density function, obtained analytically in previous studies for different climates and soils in steady-state conditions; consequently it can be used to compute both the soil moisture time-profile and the vegetation static water stress time-profile in non-steady conditions.

Here the differences between the steady-analytical and the non-steady numerical probability density functions are analyzed, showing how the proposed numerical model is able to capture the effects of winter recharge on the soil moisture. The dynamic

Modelling of loading, stress relaxation and stress recovery in a shape memory polymer.

Science.gov (United States)

Sweeney, J; Bonner, M; Ward, I M

2014-09-01

A multi-element constitutive model for a lactide-based shape memory polymer has been developed that represents loading to large tensile deformations, stress relaxation and stress recovery at 60, 65 and 70°C. The model consists of parallel Maxwell arms each comprising neo-Hookean and Eyring elements. Guiu-Pratt analysis of the stress relaxation curves yields Eyring parameters. When these parameters are used to define the Eyring process in a single Maxwell arm, the resulting model yields at too low a stress, but gives good predictions for longer times. Stress dip tests show a very stiff response on unloading by a small strain decrement. This would create an unrealistically high stress on loading to large strain if it were modelled by an elastic element. Instead it is modelled by an Eyring process operating via a flow rule that introduces strain hardening after yield. When this process is incorporated into a second parallel Maxwell arm, there results a model that fully represents both stress relaxation and stress dip tests at 60°C. At higher temperatures a third arm is required for valid predictions. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

A phenomenological model of coating/substrate adhesion and interfacial bimetallic peeling stress in composite mirrors

Science.gov (United States)

Mcelroy, Paul M.; Lawson, Daniel D.

1990-01-01

Adhesion and interfacial stress between metal films and structural composite material substrates is discussed. A theoretical and conceptual basis for selecting coating materials for composite mirror substrates is described. A phenomenological model that interrelates cohesive tensile strength of thin film coatings and interfacial peeling stresses is presented. The model serves as a basis in determining gradiated materials response and compatibility of composite substrate and coating combinations. Parametric evaluation of material properties and geometrical factors such as coating thickness are used to determine the threshold stress levels for maintaining adhesion at the different interfaces.

A standard protocol for describing individual-based and agent-based models

Science.gov (United States)

Grimm, Volker; Berger, Uta; Bastiansen, Finn; Eliassen, Sigrunn; Ginot, Vincent; Giske, Jarl; Goss-Custard, John; Grand, Tamara; Heinz, Simone K.; Huse, Geir; Huth, Andreas; Jepsen, Jane U.; Jorgensen, Christian; Mooij, Wolf M.; Muller, Birgit; Pe'er, Guy; Piou, Cyril; Railsback, Steven F.; Robbins, Andrew M.; Robbins, Martha M.; Rossmanith, Eva; Ruger, Nadja; Strand, Espen; Souissi, Sami; Stillman, Richard A.; Vabo, Rune; Visser, Ute; DeAngelis, Donald L.

2006-01-01

Simulation models that describe autonomous individual organisms (individual based models, IBM) or agents (agent-based models, ABM) have become a widely used tool, not only in ecology, but also in many other disciplines dealing with complex systems made up of autonomous entities. However, there is no standard protocol for describing such simulation models, which can make them difficult to understand and to duplicate. This paper presents a proposed standard protocol, ODD, for describing IBMs and ABMs, developed and tested by 28 modellers who cover a wide range of fields within ecology. This protocol consists of three blocks (Overview, Design concepts, and Details), which are subdivided into seven elements: Purpose, State variables and scales, Process overview and scheduling, Design concepts, Initialization, Input, and Submodels. We explain which aspects of a model should be described in each element, and we present an example to illustrate the protocol in use. In addition, 19 examples are available in an Online Appendix. We consider ODD as a first step for establishing a more detailed common format of the description of IBMs and ABMs. Once initiated, the protocol will hopefully evolve as it becomes used by a sufficiently large proportion of modellers.

Stressors, stress and stress consequences during long-duration manned space missions: a descriptive model

Science.gov (United States)

Geuna, Stefano; Brunelli, Francesco; Perino, Maria A.

Keeping crew members in good health is a major factor in the success or failure of long-duration manned space missions. Among the many possible agents that can affect the crew's general well-being, stress is certainly one of the most critical because of its implications on human health and performance, both physical and mental. Nevertheless, very few studies have been performed on this fundamental issue and none of them has addressed it in its entirity, considering its diverse physical and psychological aspects. In this work, a descriptive model is proposed to expound the mechanism and sequence of events which mediate stress. A critical analysis of the information provided by past manned spaceflights and by dedicated research performed in analogous environments is presented, and an extrapolation of the available data on human stress in such extreme conditions is proposed. Both internal and external stressors have been identified, at physical and psychosocial levels, thus providing the basis for their early detection and preventive reduction. The possible negative consequences of stress that may lead to disease in crewmembers are described. Finally, the most effective instruments which may be of help in reducing space-related human stress and treating its negative consequences are suggested.

Kinetics model of bainitic transformation with stress

Science.gov (United States)

Zhou, Mingxing; Xu, Guang; Hu, Haijiang; Yuan, Qing; Tian, Junyu

2018-01-01

Thermal simulations were conducted on a Gleeble 3800 simulator. The main purpose is to investigate the effects of stress on the kinetics of bainitic transformation in a Fe-C-Mn-Si advanced high strength bainitic steel. Previous studies on modeling the kinetics of stress affected bainitic transformation only considered the stress below the yield strength of prior austenite. In the present study, the stress above the yield strength of prior austenite is taken into account. A new kinetics model of bainitic transformation dependent on the stress (including the stresses below and above the yield strength of prior austenite) and the transformation temperature is proposed. The new model presents a good agreement with experimental results. In addition, it is found that the acceleration degree of stress on bainitic transformation increases with the stress whether its magnitude is below or above the yield strength of austenite, but the increasing rate gradually slows down when the stress is above the yield strength of austenite.

Post-traumatic stress disorder and beyond: an overview of rodent stress models.

Science.gov (United States)

Schöner, Johanna; Heinz, Andreas; Endres, Matthias; Gertz, Karen; Kronenberg, Golo

2017-10-01

Post-traumatic stress disorder (PTSD) is a psychiatric disorder of high prevalence and major socioeconomic impact. Patients suffering from PTSD typically present intrusion and avoidance symptoms and alterations in arousal, mood and cognition that last for more than 1 month. Animal models are an indispensable tool to investigate underlying pathophysiological pathways and, in particular, the complex interplay of neuroendocrine, genetic and environmental factors that may be responsible for PTSD induction. Since the 1960s, numerous stress paradigms in rodents have been developed, based largely on Seligman's seminal formulation of 'learned helplessness' in canines. Rodent stress models make use of physiological or psychological stressors such as foot shock, underwater trauma, social defeat, early life stress or predator-based stress. Apart from the brief exposure to an acute stressor, chronic stress models combining a succession of different stressors for a period of several weeks have also been developed. Chronic stress models in rats and mice may elicit characteristic PTSD-like symptoms alongside, more broadly, depressive-like behaviours. In this review, the major existing rodent models of PTSD are reviewed in terms of validity, advantages and limitations; moreover, significant results and implications for future research-such as the role of FKBP5, a mediator of the glucocorticoid stress response and promising target for therapeutic interventions-are discussed. © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

HERMES: A Model to Describe Deformation, Burning, Explosion, and Detonation

Energy Technology Data Exchange (ETDEWEB)

Reaugh, J E

2011-11-22

HERMES (High Explosive Response to MEchanical Stimulus) was developed to fill the need for a model to describe an explosive response of the type described as BVR (Burn to Violent Response) or HEVR (High Explosive Violent Response). Characteristically this response leaves a substantial amount of explosive unconsumed, the time to reaction is long, and the peak pressure developed is low. In contrast, detonations characteristically consume all explosive present, the time to reaction is short, and peak pressures are high. However, most of the previous models to describe explosive response were models for detonation. The earliest models to describe the response of explosives to mechanical stimulus in computer simulations were applied to intentional detonation (performance) of nearly ideal explosives. In this case, an ideal explosive is one with a vanishingly small reaction zone. A detonation is supersonic with respect to the undetonated explosive (reactant). The reactant cannot respond to the pressure of the detonation before the detonation front arrives, so the precise compressibility of the reactant does not matter. Further, the mesh sizes that were practical for the computer resources then available were large with respect to the reaction zone. As a result, methods then used to model detonations, known as {beta}-burn or program burn, were not intended to resolve the structure of the reaction zone. Instead, these methods spread the detonation front over a few finite-difference zones, in the same spirit that artificial viscosity is used to spread the shock front in inert materials over a few finite-difference zones. These methods are still widely used when the structure of the reaction zone and the build-up to detonation are unimportant. Later detonation models resolved the reaction zone. These models were applied both to performance, particularly as it is affected by the size of the charge, and to situations in which the stimulus was less than that needed for reliable

Reconstructing a Network of Stress-Response Regulators via Dynamic System Modeling of Gene Regulation

Directory of Open Access Journals (Sweden)

Wei-Sheng Wu

2008-01-01

Full Text Available Unicellular organisms such as yeasts have evolved mechanisms to respond to environmental stresses by rapidly reorganizing the gene expression program. Although many stress-response genes in yeast have been discovered by DNA microarrays, the stress-response transcription factors (TFs that regulate these stress-response genes remain to be investigated. In this study, we use a dynamic system model of gene regulation to describe the mechanism of how TFs may control a gene’s expression. Then, based on the dynamic system model, we develop the Stress Regulator Identification Algorithm (SRIA to identify stress-response TFs for six kinds of stresses. We identified some general stress-response TFs that respond to various stresses and some specific stress-response TFs that respond to one specifi c stress. The biological significance of our findings is validated by the literature. We found that a small number of TFs is probably suffi cient to control a wide variety of expression patterns in yeast under different stresses. Two implications can be inferred from this observation. First, the response mechanisms to different stresses may have a bow-tie structure. Second, there may be regulatory cross-talks among different stress responses. In conclusion, this study proposes a network of stress-response regulators and the details of their actions.

Modeling of residual stress mitigation in austenitic stainless steel pipe girth weldment

International Nuclear Information System (INIS)

Li, M.; Atteridge, D.G.; Anderson, W.E.; West, S.L.

1994-01-01

This study provides numerical procedures to model 40-cm-diameter, schedule 40, Type 304L stainless steel pipe girth welding and a newly proposed post-weld treatment. The treatment can be used to accomplish the goal of imparting compressive residual stresses at the inner surface of a pipe girth weldment to prevent/retard the intergranular stress corrosion cracking (IGSCC) of the piping system in nuclear reactors. This new post-weld treatment for mitigating residual stresses is cooling stress improvement (CSI). The concept of CSI is to establish and maintain a certain temperature gradient across the pipe wall thickness to change the final stress state. Thus, this process involves sub-zero low temperature cooling of the inner pipe surface of a completed girth weldment, while simultaneously keeping the outer pipe surface at a slightly elevated temperature with the help of a certain heating method. Analyses to obtain quantitative results on pipe girth welding and CSI by using a thermo-elastic-plastic finite element model are described in this paper. Results demonstrate the potential effectiveness of CSI for introducing compressive residual stresses to prevent/retard IGSCC. Because of the symmetric nature of CSI, it shows great potential for industrial application

Finite element modelling of creep process - steady state stresses and strains

Directory of Open Access Journals (Sweden)

Sedmak Aleksandar S.

2014-01-01

Full Text Available Finite element modelling of steady state creep process has been described. Using an analogy of visco-plastic problem with a described procedure, the finite element method has been used to calculate steady state stresses and strains in 2D problems. An example of application of such a procedure have been presented, using real life problem - cylindrical pipe with longitudinal crack at high temperature, under internal pressure, and estimating its residual life, based on the C*integral evaluation.

A Kinetic Model Describing Injury-Burden in Team Sports.

Science.gov (United States)

Fuller, Colin W

2017-12-01

Injuries in team sports are normally characterised by the incidence, severity, and location and type of injuries sustained: these measures, however, do not provide an insight into the variable injury-burden experienced during a season. Injury burden varies according to the team's match and training loads, the rate at which injuries are sustained and the time taken for these injuries to resolve. At the present time, this time-based variation of injury burden has not been modelled. To develop a kinetic model describing the time-based injury burden experienced by teams in elite team sports and to demonstrate the model's utility. Rates of injury were quantified using a large eight-season database of rugby injuries (5253) and exposure (60,085 player-match-hours) in English professional rugby. Rates of recovery from injury were quantified using time-to-recovery analysis of the injuries. The kinetic model proposed for predicting a team's time-based injury burden is based on a composite rate equation developed from the incidence of injury, a first-order rate of recovery from injury and the team's playing load. The utility of the model was demonstrated by examining common scenarios encountered in elite rugby. The kinetic model developed describes and predicts the variable injury-burden arising from match play during a season of rugby union based on the incidence of match injuries, the rate of recovery from injury and the playing load. The model is equally applicable to other team sports and other scenarios.

Measurement and modeling of magnetic hysteresis under field and stress application in iron–gallium alloys

International Nuclear Information System (INIS)

Evans, Phillip G.; Dapino, Marcelo J.

2013-01-01

Measurements are performed to characterize the hysteresis in magnetomechanical coupling of iron–gallium (Galfenol) alloys. Magnetization and strain of production and research grade Galfenol are measured under applied stress at constant field, applied field at constant stress, and alternately applied field and stress. A high degree of reversibility in the magnetomechanical coupling is demonstrated by comparing a series of applied field at constant stress measurements with a single applied stress at constant field measurement. Accommodation is not evident and magnetic hysteresis for applied field and stress is shown to be coupled. A thermodynamic model is formulated for 3-D magnetization and strain. It employs a stress, field, and direction dependent hysteron that has an instantaneous loss mechanism, similar to Coulomb-friction or Preisach-type models. Stochastic homogenization is utilized to account for the smoothing effect that material inhomogeneities have on bulk processes. - Highlights: ► We conduct coupled experiments and develop nonlinear thermodynamic models for magnetostrictive iron–gallium (Galfenol) alloys. ► The measurements show unexpected kinematic reversibility in the magnetomechanical coupling. ► This is in contrast with the magnetomechanical coupling in steel which is both thermodynamically and kinematically irreversible. ► The model accurately describes the measurements and provides a framework for understanding hysteresis in ferromagnetic materials which exhibit kinematically reversible magnetomechanical coupling.

Soil Compressibility Models for a Wide Stress Range

KAUST Repository

Chong, Song-Hun

2016-03-03

Soil compressibility models with physically correct asymptotic void ratios are required to analyze situations that involve a wide stress range. Previously suggested models and other functions are adapted to satisfy asymptotic void ratios at low and high stress levels; all updated models involve four parameters. Compiled consolidation data for remolded and natural clays are used to test the models and to develop correlations between model parameters and index properties. Models can adequately fit soil compression data for a wide range of stresses and soil types; in particular, models that involve the power of the stress σ\\'β display higher flexibility to capture the brittle response of some natural soils. The use of a single continuous function avoids numerical discontinuities or the need for ad hoc procedures to determine the yield stress. The tangent stiffness-readily computed for all models-should not be mistaken for the small-strain constant-fabric stiffness. © 2016 American Society of Civil Engineers.

Modeling of the flow stress for AISI H13 Tool Steel during Hard Machining Processes

Science.gov (United States)

Umbrello, Domenico; Rizzuti, Stefania; Outeiro, José C.; Shivpuri, Rajiv

2007-04-01

In general, the flow stress models used in computer simulation of machining processes are a function of effective strain, effective strain rate and temperature developed during the cutting process. However, these models do not adequately describe the material behavior in hard machining, where a range of material hardness between 45 and 60 HRC are used. Thus, depending on the specific material hardness different material models must be used in modeling the cutting process. This paper describes the development of a hardness-based flow stress and fracture models for the AISI H13 tool steel, which can be applied for range of material hardness mentioned above. These models were implemented in a non-isothermal viscoplastic numerical model to simulate the machining process for AISI H13 with various hardness values and applying different cutting regime parameters. Predicted results are validated by comparing them with experimental results found in the literature. They are found to predict reasonably well the cutting forces as well as the change in chip morphology from continuous to segmented chip as the material hardness change.

Modeling of the flow stress for AISI H13 Tool Steel during Hard Machining Processes

International Nuclear Information System (INIS)

Umbrello, Domenico; Rizzuti, Stefania; Outeiro, Jose C.; Shivpuri, Rajiv

2007-01-01

In general, the flow stress models used in computer simulation of machining processes are a function of effective strain, effective strain rate and temperature developed during the cutting process. However, these models do not adequately describe the material behavior in hard machining, where a range of material hardness between 45 and 60 HRC are used. Thus, depending on the specific material hardness different material models must be used in modeling the cutting process. This paper describes the development of a hardness-based flow stress and fracture models for the AISI H13 tool steel, which can be applied for range of material hardness mentioned above. These models were implemented in a non-isothermal viscoplastic numerical model to simulate the machining process for AISI H13 with various hardness values and applying different cutting regime parameters. Predicted results are validated by comparing them with experimental results found in the literature. They are found to predict reasonably well the cutting forces as well as the change in chip morphology from continuous to segmented chip as the material hardness change

Numerical Modeling Describing the Effects of Heterogeneous Distributions of Asperities on the Quasi-static Evolution of Frictional Slip

Science.gov (United States)

Selvadurai, P. A.; Parker, J. M.; Glaser, S. D.

2017-12-01

A better understanding of how slip accumulates along faults and its relation to the breakdown of shear stress is beneficial to many engineering disciplines, such as, hydraulic fracture and understanding induced seismicity (among others). Asperities forming along a preexisting fault resist the relative motion of the two sides of the interface and occur due to the interaction of the surface topographies. Here, we employ a finite element model to simulate circular partial slip asperities along a nominally flat frictional interface. Shear behavior of our partial slip asperity model closely matched the theory described by Cattaneo. The asperity model was employed to simulate a small section of an experimental fault formed between two bodies of polymethyl methacrylate, which consisted of multiple asperities whose location and sizes were directly measured using a pressure sensitive film. The quasi-static shear behavior of the interface was modeled for cyclical loading conditions, and the frictional dissipation (hysteresis) was normal stress dependent. We further our understanding by synthetically modeling lognormal size distributions of asperities that were randomly distributed in space. Synthetic distributions conserved the real contact area and aspects of the size distributions from the experimental case, allowing us to compare the constitutive behaviors based solely on spacing effects. Traction-slip behavior of the experimental interface appears to be considerably affected by spatial clustering of asperities that was not present in the randomly spaced, synthetic asperity distributions. Estimates of bulk interfacial shear stiffness were determined from the constitutive traction-slip behavior and were comparable to the theoretical estimates of multi-contact interfaces with non-interacting asperities.

Cyclic stress-strain behaviour under thermomechanical fatigue conditions - Modeling by means of an enhanced multi-component model

Energy Technology Data Exchange (ETDEWEB)

Christ, H J [Institut fuer Werkstofftechnik, Universitaet Siegen, D-57068 Siegen (Germany); Bauer, V, E-mail: hans-juergen.christ@uni-siegen.d [Wieland Werke AG, Graf-Arco Str. 36, D-89072 Ulm (Germany)

2010-07-01

The cyclic stress-strain behaviour of metals and alloys in cyclic saturation can reasonably be described by means of simple multi-component models, such as the model based on a parallel arrangement of elastic-perfectly plastic elements, which was originally proposed by Masing already in 1923. This model concept was applied to thermomechanical fatigue loading of two metallic engineering materials which were found to be rather oppositional with respect to cyclic plastic deformation. One material is an austenitic stainless steel of type AISI304L which shows dynamic strain aging (DSA) and serves as an example for a rather ductile alloy. A dislocation arrangement was found after TMF testing deviating characteristically from the corresponding isothermal microstructures. The second material is a third-generation near-gamma TiAl alloy which is characterized by a very pronounced ductile-to-brittle transition (DBT) within the temperature range of TMF cycling. Isothermal fatigue testing at temperatures below the DBT temperature leads to cyclic hardening, while cyclic softening was found to occur above DBT. The combined effect under TMF leads to a continuously developing mean stress. The experimental observations regarding isothermal and non-isothermal stress-strain behaviour and the correlation to the underlying microstructural processes was used to further develop the TMF multi-composite model in order to accurately predict the TMF stress-strain response by taking the alloy-specific features into account.

A Model of Teacher Stress

Science.gov (United States)

Kyriacou, Chris; Sutcliffe, John

1978-01-01

A definition and model of teacher stress is presented which conceptualizes teacher stress as a response syndrome (anger or depression) mediated by (1) an appraisal of threat to the teacher's self-esteem or well-being and (2) coping mechanisms activated to reduce the perceived threat. (Author)

A stress-induced phase transition model for semi-crystallize shape memory polymer

Science.gov (United States)

Guo, Xiaogang; Zhou, Bo; Liu, Liwu; Liu, Yanju; Leng, Jinsong

2014-03-01

The developments of constitutive models for shape memory polymer (SMP) have been motivated by its increasing applications. During cooling or heating process, the phase transition which is a continuous time-dependent process happens in semi-crystallize SMP and the various individual phases form at different temperature and in different configuration. Then, the transformation between these phases occurred and shape memory effect will emerge. In addition, stress applied on SMP is an important factor for crystal melting during phase transition. In this theory, an ideal phase transition model considering stress or pre-strain is the key to describe the behaviors of shape memory effect. So a normal distributed model was established in this research to characterize the volume fraction of each phase in SMP during phase transition. Generally, the experiment results are partly backward (in heating process) or forward (in cooling process) compared with the ideal situation considering delay effect during phase transition. So, a correction on the normal distributed model is needed. Furthermore, a nonlinear relationship between stress and phase transition temperature Tg is also taken into account for establishing an accurately normal distributed phase transition model. Finally, the constitutive model which taking the stress as an influence factor on phase transition was also established. Compared with the other expressions, this new-type model possesses less parameter and is more accurate. For the sake of verifying the rationality and accuracy of new phase transition and constitutive model, the comparisons between the simulated and experimental results were carried out.

A new stress corrosion cracking model for Inconel 600 in PWR media

International Nuclear Information System (INIS)

Magnin, T.

1993-01-01

A model of cracking in corrosion under stress, based on corrosion-plasticity interactions at cracking points, is proposed to describe the generally intergranular breakage of Inconel 600 in PWR medium. It is shown by calculation, and verified experimentally by observations in SEM, that a pseudo-intergranular breakage connected to the formation of micro facets in zigzags along the joints is possible, as well as a completely intergranular breakage. This allows us to assume that a continuity of mechanisms exists between the trans- and intergranular cracking by corrosion under material stress. (author)

Internal stress model for pre-primary stage of low-stress creep

International Nuclear Information System (INIS)

Kloc, L

2010-01-01

Initial transient stage in low-stress creep experiments was observed in all such experiments. Recently, evidences were presented that this stage cannot be considered as a normal creep primary stage, though the shape of the creep curve is similar. The strain reached during this so called pre-primary stage is fully recoverable upon unloading; the internal stresses must play important role in the effect. Model of standard linear anelastic solid was modified by introduction of creeping body instead of viscous dashpot. Both power law and hyperbolic sine creep law were used to fit observed creep curves of model and structural materials. Mainly the model using hyeprbolic sine creep law provides good fit to individual creep curves and sets of creep curves at different stresses.

New constitutive equations to describe infinitesimal elastic-plastic deformations

International Nuclear Information System (INIS)

Boecke, B.; Link, F.; Schneider, G.; Bruhns, O.T.

1983-01-01

A set of constitutive equations is presented to describe infinitesimal elastic-plastic deformations of austenitic steel in the range up to 600 deg C. This model can describe the hardening behaviour in the case of mechanical loading and hardening, and softening behaviour in the case of thermal loading. The loading path can be either monotonic or cyclic. For this purpose, the well-known isotropic hardening model is continually transferred into the kinematic model according to Prager, whereby suitable internal variables are chosen. The occurring process-dependent material functions are to be determined by uniaxial experiments. The hardening function g and the translation function c are determined by means of a linearized stress-strain behaviour in the plastic range, whereby a coupling condition must be taken into account. As a linear hardening process is considered to be too unrealistic, nonlinearity is achieved by introducing a small function w, the determination procedure of which is given. (author)

A closed-loop hybrid physiological model relating to subjects under physical stress.

Science.gov (United States)

El-Samahy, Emad; Mahfouf, Mahdi; Linkens, Derek A

2006-11-01

The objective of this research study is to derive a comprehensive physiological model relating to subjects under physical stress conditions. The model should describe the behaviour of the cardiovascular system, respiratory system, thermoregulation and brain activity in response to physical workload. An experimental testing rig was built which consists of recumbent high performance bicycle for inducing the physical load and a data acquisition system comprising monitors and PCs. The signals acquired and used within this study are the blood pressure, heart rate, respiration, body temperature, and EEG signals. The proposed model is based on a grey-box based modelling approach which was used because of the sufficient level of details it provides. Cardiovascular and EEG Data relating to 16 healthy subject volunteers (data from 12 subjects were used for training/validation and the data from 4 subjects were used for model testing) were collected using the Finapres and the ProComp+ monitors. For model validation, residual analysis via the computing of the confidence intervals as well as related histograms was performed. Closed-loop simulations for different subjects showed that the model can provide reliable predictions for heart rate, blood pressure, body temperature, respiration, and the EEG signals. These findings were also reinforced by the residual analyses data obtained, which suggested that the residuals were within the 90% confidence bands and that the corresponding histograms were of a normal distribution. A higher intelligent level was added to the model, based on neural networks, to extend the capabilities of the model to predict over a wide range of subjects dynamics. The elicited physiological model describing the effect of physiological stress on several physiological variables can be used to predict performance breakdown of operators in critical environments. Such a model architecture lends itself naturally to exploitation via feedback control in a 'reverse

Models for describing the thermal characteristics of building components

DEFF Research Database (Denmark)

Jimenez, M.J.; Madsen, Henrik

2008-01-01

, for example. For the analysis of these tests, dynamic analysis models and methods are required. However, a wide variety of models and methods exists, and the problem of choosing the most appropriate approach for each particular case is a non-trivial and interdisciplinary task. Knowledge of a large family....... The characteristics of each type of model are highlighted. Some available software tools for each of the methods described will be mentioned. A case study also demonstrating the difference between linear and nonlinear models is considered....... of these approaches may therefore be very useful for selecting a suitable approach for each particular case. This paper presents an overview of models that can be applied for modelling the thermal characteristics of buildings and building components using data from outdoor testing. The choice of approach depends...

STRESS RESPONSE STUDIES USING ANIMAL MODELS

Science.gov (United States)

This presentation will provide the evidence that ozone exposure in animal models induce neuroendocrine stress response and this stress response modulates lung injury and inflammation through adrenergic and glucocorticoid receptors.

Improvement and Validation of Weld Residual Stress Modelling Procedure

International Nuclear Information System (INIS)

Zang, Weilin; Gunnars, Jens; Dong, Pingsha; Hong, Jeong K.

2009-06-01

The objective of this work is to identify and evaluate improvements for the residual stress modelling procedure currently used in Sweden. There is a growing demand to eliminate any unnecessary conservatism involved in residual stress assumptions. The study was focused on the development and validation of an improved weld residual stress modelling procedure, by taking advantage of the recent advances in residual stress modelling and stress measurement techniques. The major changes applied in the new weld residual stress modelling procedure are: - Improved procedure for heat source calibration based on use of analytical solutions. - Use of an isotropic hardening model where mixed hardening data is not available. - Use of an annealing model for improved simulation of strain relaxation in re-heated material. The new modelling procedure is demonstrated to capture the main characteristics of the through thickness stress distributions by validation to experimental measurements. Three austenitic stainless steel butt-welds cases are analysed, covering a large range of pipe geometries. From the cases it is evident that there can be large differences between the residual stresses predicted using the new procedure, and the earlier procedure or handbook recommendations. Previously recommended profiles could give misleading fracture assessment results. The stress profiles according to the new procedure agree well with the measured data. If data is available then a mixed hardening model should be used

Improvement and Validation of Weld Residual Stress Modelling Procedure

Energy Technology Data Exchange (ETDEWEB)

Zang, Weilin; Gunnars, Jens (Inspecta Technology AB, Stockholm (Sweden)); Dong, Pingsha; Hong, Jeong K. (Center for Welded Structures Research, Battelle, Columbus, OH (United States))

2009-06-15

The objective of this work is to identify and evaluate improvements for the residual stress modelling procedure currently used in Sweden. There is a growing demand to eliminate any unnecessary conservatism involved in residual stress assumptions. The study was focused on the development and validation of an improved weld residual stress modelling procedure, by taking advantage of the recent advances in residual stress modelling and stress measurement techniques. The major changes applied in the new weld residual stress modelling procedure are: - Improved procedure for heat source calibration based on use of analytical solutions. - Use of an isotropic hardening model where mixed hardening data is not available. - Use of an annealing model for improved simulation of strain relaxation in re-heated material. The new modelling procedure is demonstrated to capture the main characteristics of the through thickness stress distributions by validation to experimental measurements. Three austenitic stainless steel butt-welds cases are analysed, covering a large range of pipe geometries. From the cases it is evident that there can be large differences between the residual stresses predicted using the new procedure, and the earlier procedure or handbook recommendations. Previously recommended profiles could give misleading fracture assessment results. The stress profiles according to the new procedure agree well with the measured data. If data is available then a mixed hardening model should be used

Nonlinear analysis of pre-stressed concrete containment vessel (PCCV) using the damage plasticity model

Energy Technology Data Exchange (ETDEWEB)

Shokoohfar, Ahmad; Rahai, Alireza, E-mail: rahai@aut.ac.ir

2016-03-15

Highlights: • This paper describes nonlinear analyses of a 1:4 scale model of a (PCCV). • Coupled temp-disp. analysis and concrete damage plasticity are considered. • Temperature has limited effects on correct failure mode estimation. • Higher pre-stressing forces have limited effects on ultimate radial displacements. • Anchorage details of liner plates leads to prediction of correct failure mode. - Abstract: This paper describes the nonlinear analyses of a 1:4 scale model of a pre-stressed concrete containment vessel (PCCV). The analyses are performed under pressure and high temperature effects with considering anchorage details of liner plate. The temperature-time history of the model test is considered as an input boundary condition in the coupled temp-displacement analysis. The constitutive model developed by Chang and Mander (1994) is adopted in the model as the basis for the concrete stress–strain relation. To trace the crack pattern of the PCCV concrete faces, the concrete damage plasticity model is applied. This study includes the results of the thermal and mechanical behaviors of the PCCV subject to temperature loading and internal pressure at the same time. The test results are compared with the analysis results. The analysis results show that the temperature has little impact on the ultimate pressure capacity of the PCCV. To simulate the exact failure mode of the PCCV, the anchorage details of the liner plates around openings should be maintained in the analytical models. Also the failure mode of the PCCV structure hasn’t influenced by hoop tendons pre-stressing force variations.

A comprehensive model of stress - The roles of experienced stress and neuroticism in explaining the stress-distress relationship

NARCIS (Netherlands)

De Jong, GM; van Sonderen, E; Emmelkamp, PMG

1999-01-01

Background: In this study, a complex theoretical model regarding the stress-distress relationship was evaluated. The various components in the model included experienced stress (daily hassles), psychological distress, neuroticism, problem-focused coping, avoidant coping, satisfaction with received

Modeling stress wave propagation in rocks by distinct lattice spring model

Directory of Open Access Journals (Sweden)

Gaofeng Zhao

2014-08-01

Full Text Available In this paper, the ability of the distinct lattice spring model (DLSM for modeling stress wave propagation in rocks was fully investigated. The influence of particle size on simulation of different types of stress waves (e.g. one-dimensional (1D P-wave, 1D S-wave and two-dimensional (2D cylindrical wave was studied through comparing results predicted by the DLSM with different mesh ratios (lr and those obtained from the corresponding analytical solutions. Suggested values of lr were obtained for modeling these stress waves accurately. Moreover, the weak material layer method and virtual joint plane method were used to model P-wave and S-wave propagating through a single discontinuity. The results were compared with the classical analytical solutions, indicating that the virtual joint plane method can give better results and is recommended. Finally, some remarks of the DLSM on modeling of stress wave propagation in rocks were provided.

Effects of Photobiomodulation Therapy on Oxidative Stress in Muscle Injury Animal Models: A Systematic Review

Directory of Open Access Journals (Sweden)

Solange Almeida dos Santos

2017-01-01

Full Text Available This systematic review was performed to identify the role of photobiomodulation therapy on experimental muscle injury models linked to induce oxidative stress. EMBASE, PubMed, and CINAHL were searched for studies published from January 2006 to January 2016 in the areas of laser and oxidative stress. Any animal model using photobiomodulation therapy to modulate oxidative stress was included in analysis. Eight studies were selected from 68 original articles targeted on laser irradiation and oxidative stress. Articles were critically assessed by two independent raters with a structured tool for rating the research quality. Although the small number of studies limits conclusions, the current literature indicates that photobiomodulation therapy can be an effective short-term approach to reduce oxidative stress markers (e.g., thiobarbituric acid-reactive and to increase antioxidant substances (e.g., catalase, glutathione peroxidase, and superoxide dismutase. However, there is a nonuniformity in the terminology used to describe the parameters and dose for low-level laser treatment.

A hierarchical stress release model for synthetic seismicity

Science.gov (United States)

Bebbington, Mark

1997-06-01

We construct a stochastic dynamic model for synthetic seismicity involving stochastic stress input, release, and transfer in an environment of heterogeneous strength and interacting segments. The model is not fault-specific, having a number of adjustable parameters with physical interpretation, namely, stress relaxation, stress transfer, stress dissipation, segment structure, strength, and strength heterogeneity, which affect the seismicity in various ways. Local parameters are chosen to be consistent with large historical events, other parameters to reproduce bulk seismicity statistics for the fault as a whole. The one-dimensional fault is divided into a number of segments, each comprising a varying number of nodes. Stress input occurs at each node in a simple random process, representing the slow buildup due to tectonic plate movements. Events are initiated, subject to a stochastic hazard function, when the stress on a node exceeds the local strength. An event begins with the transfer of excess stress to neighboring nodes, which may in turn transfer their excess stress to the next neighbor. If the event grows to include the entire segment, then most of the stress on the segment is transferred to neighboring segments (or dissipated) in a characteristic event. These large events may themselves spread to other segments. We use the Middle America Trench to demonstrate that this model, using simple stochastic stress input and triggering mechanisms, can produce behavior consistent with the historical record over five units of magnitude. We also investigate the effects of perturbing various parameters in order to show how the model might be tailored to a specific fault structure. The strength of the model lies in this ability to reproduce the behavior of a general linear fault system through the choice of a relatively small number of parameters. It remains to develop a procedure for estimating the internal state of the model from the historical observations in order to

Stress Models of the Annual Hydrospheric, Atmospheric, Thermal, and Tidal Loading Cycles on California Faults: Perturbation of Background Stress and Changes in Seismicity

Science.gov (United States)

Johnson, Christopher W.; Fu, Yuning; Bürgmann, Roland

2017-12-01

Stresses in the lithosphere arise from multiple natural loading sources that include both surface and body forces. The largest surface loads include near-surface water storage, snow and ice, atmosphere pressure, ocean loading, and temperature changes. The solid Earth also deforms from celestial body interactions and variations in Earth's rotation. We model the seasonal stress changes in California from 2006 through 2014 for seven different loading sources with annual periods to produce an aggregate stressing history for faults in the study area. Our modeling shows that the annual water loading, atmosphere, temperature, and Earth pole tides are the largest loading sources and should each be evaluated to fully describe seasonal stress changes. In California we find that the hydrological loads are the largest source of seasonal stresses. We explore the seasonal stresses with respect to the background principal stress orientation constrained with regional focal mechanisms and analyze the modulation of seismicity. Our results do not suggest a resolvable seasonal variation for the ambient stress orientation in the shallow crust. When projecting the seasonal stresses into the background stress orientation we find that the timing of microseismicity modestly increases from an 8 kPa seasonal mean-normal-stress perturbation. The results suggest that faults in California are optimally oriented with the background stress field and respond to subsurface pressure changes, possibly due to processes we have not considered in this study. At any time a population of faults are near failure as evident from earthquakes triggered by these slight seasonal stress perturbations.

Constitutive modeling of stress-driven grain growth in nanocrystalline metals

KAUST Repository

Gürses, Ercan

2013-02-08

In this work, we present a variational multiscale model for grain growth in face-centered cubic nanocrystalline (nc) metals. In particular, grain-growth-induced stress softening and the resulting relaxation phenomena are addressed. The behavior of the polycrystal is described by a conventional Taylor-type averaging scheme in which the grains are treated as two-phase composites consisting of a grain interior phase and a grain boundary-affected zone. Furthermore, a grain-growth law that captures the experimentally observed characteristics of the grain coarsening phenomena is proposed. To this end, the grain size is not taken as constant and varies according to the proposed stress-driven growth law. Several parametric studies are conducted to emphasize the influence of the grain-growth rule on the overall macroscopic response. Finally, the model is shown to provide a good description of the experimentally observed grain-growth-induced relaxation in nc-copper. © 2013 IOP Publishing Ltd.

Stress dependent fluid flow in porous rock: experiments and network modelling

Energy Technology Data Exchange (ETDEWEB)

Flornes, Olav

2005-07-01

permeability change was the same in the two directions. When a rock is subjected to sufficiently high stresses, permanent damage, or failure, occurs and we expect a more drastic change in its properties. In a series of experiments on three different materials, we study how permeability is changed by different failure modes. We observed that permeability followed the volumetric strain independent of failure mode in two of the materials, Saltwash and Tuffeau de Maastricht, while for Red Wildmoor, the permeability changed in a more complex manner. We present two numerical models that study how deformation and fluid flow are related. While they are both network models, one is focused on the effect of changed porosity on permeability, and tries to give some insight to the experimental results described above. The other one is more theoretical, and investigates some universal properties associated with hydraulic fracturing using a Biot-Cosserat model (author) (ml)

Analytical model of stress field in submerged arc welding butt joint with thorough penetration

Directory of Open Access Journals (Sweden)

Winczek Jerzy

2018-01-01

Full Text Available Analytical model of temporary and residual stresses for butt welding with thorough penetration was described assuming planar section hypothesis and using integral equations of stress equilibrium of the bar and simple Hooke’s law. In solution the effect of phase transformations (structure changes and structural strains has been taken into account. Phase transformations during heating are limited by temperature values at the beginning and at the end of austenitic transformation, depending on chemical composition of steel while the progress of phase transformations during cooling is determined on the basis of TTT-welding diagram. Temperature values at the beginning and at the end of transformation are conditioned by the speed of heating. Kinetics of diffusional transformation is described basing on Johnson-Mehl-Avrami-Kolmogorov equation, while martensitic transformation, basing on Koistinen-Marburger equation. Stresses in elasto-plastic state are determined by iteration, using elastic solutions method with changeable longitudinal modulus of elasticity, conditioned by stress-strain curve. Computations of stress field have been conducted for one-side butt welded of two steel flats made from S235 steel. It has enabled a clear interpretation of influence of temperature field and phase transformation on stresses caused by welding using Submerged Arc Welding (SAW method.

Modified Feddes type stress reduction function for modeling root water uptake: Accounting for limited aeration and low water potential

Science.gov (United States)

Peters, Andre; Durner, Wolfgang; Iden, Sascha C.

2017-04-01

Modeling water flow in the soil-plant-atmosphere continuum with the Richards equation requires a model for the sink term describing water uptake by plant roots. Despite recent progress in developing process-based models of water uptake by plant roots and water flow in aboveground parts of vegetation, effective models of root water uptake are widely applied and necessary for large-scale applications. Modeling root water uptake consists of three steps, (i) specification of the spatial distribution of potential uptake, (ii) reduction of uptake due to various stress sources, and (iii) enhancement of uptake in part of the simulation domain to describe compensation. We discuss the conceptual shortcomings of the frequently used root water uptake model of Feddes and suggest a simple but effective improvement of the model. The improved model parametrizes water stress in wet soil by a reduction scheme which is formulated as function of air content where water stress due to low soil water potential is described by the original approach of Feddes. The improved model is physically more consistent than Feddes' model because water uptake in wet soil is limited by aeration which is a function of water content. The suggested modification is particularly relevant for simulations in heterogeneous soils, because stress parameters are uniquely defined for the entire simulation domain, irrespective of soil texture. Numerical simulations of water flow and root water uptake in homogeneous and stochastic heterogeneous soils illustrate the effect of the new model on root water uptake and actual transpiration. For homogeneous fine-textured soils, root water uptake never achieves its potential rate. In stochastic heterogeneous soil, water uptake is more pronounced at the interfaces between fine and coarse regions which has potential implications for plant growth, nutrient uptake and depletion.

An Agent-Based Modeling Framework for Simulating Human Exposure to Environmental Stresses in Urban Areas

Directory of Open Access Journals (Sweden)

Liang Emlyn Yang

2018-04-01

Full Text Available Several approaches have been used to assess potential human exposure to environmental stresses and achieve optimal results under various conditions, such as for example, for different scales, groups of people, or points in time. A thorough literature review in this paper identifies the research gap regarding modeling approaches for assessing human exposure to environment stressors, and it indicates that microsimulation tools are becoming increasingly important in human exposure assessments of urban environments, in which each person is simulated individually and continuously. The paper further describes an agent-based model (ABM framework that can dynamically simulate human exposure levels, along with their daily activities, in urban areas that are characterized by environmental stresses such as air pollution and heat stress. Within the framework, decision-making processes can be included for each individual based on rule-based behavior in order to achieve goals under changing environmental conditions. The ideas described in this paper are implemented in a free and open source NetLogo platform. A basic modeling scenario of the ABM framework in Hamburg, Germany, demonstrates its utility in various urban environments and individual activity patterns, as well as its portability to other models, programs, and frameworks. The prototype model can potentially be extended to support environmental incidence management through exploring the daily routines of different groups of citizens, and comparing the effectiveness of different strategies. Further research is needed to fully develop an operational version of the model.

Recent progress in the development of the Elliptic Blending Reynolds-stress model

International Nuclear Information System (INIS)

Manceau, Rémi

2015-01-01

Highlights: • Various modifications of the Elliptic Blending Reynolds stress model, proposed during the last decade, are revisited. • Using theoretical arguments and detailed comparison with DNS data, a reference model is formulated. • The model satisfactorily reproduces the effects of spanwise rotation on turbulence, for cases without and with separation. - Abstract: The Elliptic Blending Reynolds Stress Model (EB-RSM), originally proposed by Manceau and Hanjalić (2002) to extend standard, weakly inhomogeneous Reynolds stress models to the near-wall region, has been subject to various modifications by several authors during the last decade, mainly for numerical robustness reasons. The present work revisits all these modifications from the theoretical standpoint and investigates in detail their influence on the reproduction of the physical mechanisms at the origin of the influence of the wall on turbulence. The analysis exploits recent DNS databases for high-Reynolds number channel flows, spanwise rotating channel flows with strong rotation rates, up to complete laminarization, and the separated flow after a sudden expansion without and with system rotation. Theoretical arguments and comparison with DNS results lead to the selection of a recommended formulation for the EB-RSM model. This formulation shows satisfactory predictions for the configurations described above, in particular as regards the modification of the mean flow and turbulent anisotropy on the anticyclonic or pressure side

ANSYS Modeling of Hydrostatic Stress Effects

Science.gov (United States)

Allen, Phillip A.

1999-01-01

Classical metal plasticity theory assumes that hydrostatic pressure has no effect on the yield and postyield behavior of metals. Plasticity textbooks, from the earliest to the most modem, infer that there is no hydrostatic effect on the yielding of metals, and even modem finite element programs direct the user to assume the same. The object of this study is to use the von Mises and Drucker-Prager failure theory constitutive models in the finite element program ANSYS to see how well they model conditions of varying hydrostatic pressure. Data is presented for notched round bar (NRB) and "L" shaped tensile specimens. Similar results from finite element models in ABAQUS are shown for comparison. It is shown that when dealing with geometries having a high hydrostatic stress influence, constitutive models that have a functional dependence on hydrostatic stress are more accurate in predicting material behavior than those that are independent of hydrostatic stress.

Fractional calculus model of articular cartilage based on experimental stress-relaxation

Science.gov (United States)

Smyth, P. A.; Green, I.

2015-05-01

Articular cartilage is a unique substance that protects joints from damage and wear. Many decades of research have led to detailed biphasic and triphasic models for the intricate structure and behavior of cartilage. However, the models contain many assumptions on boundary conditions, permeability, viscosity, model size, loading, etc., that complicate the description of cartilage. For impact studies or biomimetic applications, cartilage can be studied phenomenologically to reduce modeling complexity. This work reports experimental results on the stress-relaxation of equine articular cartilage in unconfined loading. The response is described by a fractional calculus viscoelastic model, which gives storage and loss moduli as functions of frequency, rendering multiple advantages: (1) the fractional calculus model is robust, meaning that fewer constants are needed to accurately capture a wide spectrum of viscoelastic behavior compared to other viscoelastic models (e.g., Prony series), (2) in the special case where the fractional derivative is 1/2, it is shown that there is a straightforward time-domain representation, (3) the eigenvalue problem is simplified in subsequent dynamic studies, and (4) cartilage stress-relaxation can be described with as few as three constants, giving an advantage for large-scale dynamic studies that account for joint motion or impact. Moreover, the resulting storage and loss moduli can quantify healthy, damaged, or cultured cartilage, as well as artificial joints. The proposed characterization is suited for high-level analysis of multiphase materials, where the separate contribution of each phase is not desired. Potential uses of this analysis include biomimetic dampers and bearings, or artificial joints where the effective stiffness and damping are fundamental parameters.

A unified model to describe the anisotropic viscoplastic behavior of Zircaloy-4 cladding tubes

International Nuclear Information System (INIS)

Delobelle, P.; Robinet, P.; Bouffioux, P.; Geyer, P.; Pichon, I. Le

1996-01-01

This paper presents the constitutive equations of a unified viscoplastic model and its validation with experimental data. The mechanical tests were carried out in a temperature range of 20 to 400 C on both cold-worked stress-relieved and fully annealed Zircaloy-4 tubes. Although their geometry (14.3 by 1.2 mm) is different, the crystallographic texture was close to that expected in the cladding tubes. To characterize the anisotropy, mechanical tests were performed under both monotonic and cyclic uni- and bi-directional loadings, i.e., tension-compression, tension-torsion, and tension-internal pressure tests. The results obtained at ambient temperatures and the independence of the ratio R p = var-epsilon θθ p /var-epsilon zz p , with respect to temperature would seem to indicate that the set of anisotropy coefficients does not depend on temperature. Zircaloy-4 material also has a slight supplementary hardening during out-of-phase cyclic loading. The authors propose to extend the formulation of a unified viscoplastic model, developed and identified elsewhere for other initially isotropic materials, to the case of Zircaloy-4. Generally speaking, anisotropy is introduced through fourth order tensors affecting the flow directions, the linear kinematical hardening components, as well as the dynamic and static recoveries of the forementioned hardening variables. The ability of the model to describe all the mechanical properties of the material is shown. The application of the model to simulate mechanical tests (tension, creep, and relaxation) performed on true CWSR Zircaloy-4 cladding tubes with low tin content is also presented

Algebraic stress model for axial flow in a bare rod-bundle

International Nuclear Information System (INIS)

de Lemos, M.J.S.

1987-01-01

The problem of predicting transport properties for momentum and heat across the boundaries of interconnected channels has been the subject of many investigations. In the particular case of axial flow through rod-bundles, transport coefficients for channel faces aligned with rod centers are known to be considerably higher than those calculated by simple isotropic theories. And yet, it was been found that secondary flows play only a minor role in this overall transport, being turbulence highly enhanced across that hypothetical surface. In order to numerically predict the correct amount of the quantity being transported, the approach taken by many investigators was then to artificially increase the diffusion coefficient obtained via a simple isopropic theory (usually the standard k-ε model) and numerically match the correct experimentally observed mixing rates. The present paper reports an attempt to describe the turbulent stresses by means of an Algebraic Stress Model for turbulence. Relative turbulent kinetic energy distribution in all three directions are presented and compared with experiments in a square lattice. The strong directional dependence of transport terms are then obtained via a model for the Reynolds stresses. The results identify a need for a better representation of the mean-flow field part of the pressure-strain correlation term

Adaptation of endothelial cells to physiologically-modeled, variable shear stress.

Directory of Open Access Journals (Sweden)

Joseph S Uzarski

Full Text Available Endothelial cell (EC function is mediated by variable hemodynamic shear stress patterns at the vascular wall, where complex shear stress profiles directly correlate with blood flow conditions that vary temporally based on metabolic demand. The interactions of these more complex and variable shear fields with EC have not been represented in hemodynamic flow models. We hypothesized that EC exposed to pulsatile shear stress that changes in magnitude and duration, modeled directly from real-time physiological variations in heart rate, would elicit phenotypic changes as relevant to their critical roles in thrombosis, hemostasis, and inflammation. Here we designed a physiological flow (PF model based on short-term temporal changes in blood flow observed in vivo and compared it to static culture and steady flow (SF at a fixed pulse frequency of 1.3 Hz. Results show significant changes in gene regulation as a function of temporally variable flow, indicating a reduced wound phenotype more representative of quiescence. EC cultured under PF exhibited significantly higher endothelial nitric oxide synthase (eNOS activity (PF: 176.0±11.9 nmol/10(5 EC; SF: 115.0±12.5 nmol/10(5 EC, p = 0.002 and lower TNF-a-induced HL-60 leukocyte adhesion (PF: 37±6 HL-60 cells/mm(2; SF: 111±18 HL-60/mm(2, p = 0.003 than cells cultured under SF which is consistent with a more quiescent anti-inflammatory and anti-thrombotic phenotype. In vitro models have become increasingly adept at mimicking natural physiology and in doing so have clarified the importance of both chemical and physical cues that drive cell function. These data illustrate that the variability in metabolic demand and subsequent changes in perfusion resulting in constantly variable shear stress plays a key role in EC function that has not previously been described.

Preclinical experimental stress studies: protocols, assessment and comparison.

Science.gov (United States)

Bali, Anjana; Jaggi, Amteshwar Singh

2015-01-05

Stress is a state of threatened homeostasis during which a variety of adaptive processes are activated to produce physiological and behavioral changes. Preclinical models are pivotal for understanding these physiological or pathophysiological changes in the body in response to stress. Furthermore, these models are also important for the development of novel pharmacological agents for stress management. The well described preclinical stress models include immobilization, restraint, electric foot shock and social isolation stress. Stress assessment in animals is done at the behavioral level using open field, social interaction, hole board test; at the biochemical level by measuring plasma corticosterone and ACTH; at the physiological level by measuring food intake, body weight, adrenal gland weight and gastric ulceration. Furthermore the comparison between different stressors including electric foot shock, immobilization and cold stressor is described in terms of intensity, hormonal release, protein changes in brain, adaptation and sleep pattern. This present review describes these preclinical stress protocols, and stress assessment at different levels. Copyright © 2014 Elsevier B.V. All rights reserved.

Modeling flow stress constitutive behavior of SA508-3 steel for nuclear reactor pressure vessels

Energy Technology Data Exchange (ETDEWEB)

Sun Mingyue, E-mail: mysun@imr.ac.cn [Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016 (China); Luhan, Hao; Shijian, Li; Dianzhong, Li; Yiyi, Li [Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016 (China)

2011-11-15

Highlights: > A series of flow stress constitutive equations for SA508-3 steel were successfully established. > The experimental results under different conditions have validated the constitutive equations. > An industrial application of the model was present to simulate a large conical shell forging process. - Abstract: Based on the measured stress-strain curves under different temperatures and strain rates, a series of flow stress constitutive equations for SA508-3 steel were firstly established through the classical theories on work hardening and softening. The comparison between the experimental and modeling results has confirmed that the established constitutive equations can correctly describe the mechanical responses and microstructural evolutions of the steel under various hot deformation conditions. We further represented a successful industrial application of this model to simulate a forging process for a large conical shell used in a nuclear steam generator, which evidences its practical and promising perspective of our model with an aim of widely promoting the hot plasticity processing for heavy nuclear components of fission reactors.

Modeling Exposure to Heat Stress with a Simple Urban Model

Directory of Open Access Journals (Sweden)

Peter Hoffmann

2018-01-01

Full Text Available As a first step in modeling health-related urban well-being (UrbWellth, a mathematical model is constructed that dynamically simulates heat stress exposure of commuters in an idealized city. This is done by coupling the Simple Urban Radiation Model (SURM, which computes the mean radiant temperature ( T m r t , with a newly developed multi-class multi-mode traffic model. Simulation results with parameters chosen for the city of Hamburg for a hot summer day show that commuters are potentially most exposed to heat stress in the early afternoon when T m r t has its maximum. Varying the morphology with respect to street width and building height shows that a more compact city configuration reduces T m r t and therefore the exposure to heat stress. The impact resulting from changes in the city structure on traffic is simulated to determine the time spent outside during the commute. While the time in traffic jams increases for compact cities, the total commuting time decreases due to shorter distances between home and work place. Concerning adaptation measures, it is shown that increases in the albedo of the urban surfaces lead to an increase in daytime heat stress. Dramatic increases in heat stress exposure are found when both, wall and street albedo, are increased.

Resilience in shock and swim stress models of depression

Directory of Open Access Journals (Sweden)

Robert Charles Drugan

2013-02-01

Full Text Available Experimental models of depression often entail exposing a rodent to a stressor and subsequently characterizing changes in learning and anhedonia, which may reflect symptoms of human depression. Importantly, not all people and not all laboratory rats exposed to stressors develop depressed behavior; these resilient individuals are the focus of our review. Herein we describe research from the learned helplessness and intermittent swim stress models of depression in which rats that were allowed to cope with the stressor appear to be behaviorally and neurochemically similar to rats that were not allowed to cope yet appeared resilient in behavioral tests. For example, rats exposed to inescapable tailshock, but do not develop learned helplessness, exhibit altered sensitivity to the behavioral effects of GABAA receptor antagonists and reduced in vitro benzodiazepine receptor ligand binding. This pattern suggested that resilience might involve activation of an endogenous benzodiazepine-like compound, possibly an allostatic modulator of the GABAA receptor like allopregnanolone. From the intermittent swim stress model, we have observed in resilient rats protection from stressor-induced glucocorticoid increases and immune activation. In order to identify the neural mediators of these correlates of resilience, non-invasive measures are needed to predict the resilient or vulnerable phenotype prior to analysis of neural endpoints. To this end, we found that ultrasonic vocalizations (USVs appear to predict the resilient phenotype in the intermittent swim stress paradigm. We propose that combining non-invasive predictive measures, such as USVs with biological endpoint measures, will facilitate future research into the neural correlates of resilience.

Stress-Induced Visceral Pain: Toward Animal Models of Irritable-Bowel Syndrome and Associated Comorbidities

Science.gov (United States)

Moloney, Rachel D.; O’Mahony, Siobhain M.; Dinan, Timothy G.; Cryan, John F.

2015-01-01

Visceral pain is a global term used to describe pain originating from the internal organs, which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders such as irritable-bowel syndrome (IBS). Currently, the treatment strategies targeting visceral pain are unsatisfactory, with development of novel therapeutics hindered by a lack of detailed knowledge of the underlying mechanisms. Stress has long been implicated in the pathophysiology of visceral pain in both preclinical and clinical studies. Here, we discuss the complex etiology of visceral pain reviewing our current understanding in the context of the role of stress, gender, gut microbiota alterations, and immune functioning. Furthermore, we review the role of glutamate, GABA, and epigenetic mechanisms as possible therapeutic strategies for the treatment of visceral pain for which there is an unmet medical need. Moreover, we discuss the most widely described rodent models used to model visceral pain in the preclinical setting. The theory behind, and application of, animal models is key for both the understanding of underlying mechanisms and design of future therapeutic interventions. Taken together, it is apparent that stress-induced visceral pain and its psychiatric comorbidities, as typified by IBS, has a multifaceted etiology. Moreover, treatment strategies still lag far behind when compared to other pain modalities. The development of novel, effective, and specific therapeutics for the treatment of visceral pain has never been more pertinent. PMID:25762939

A proposed residual stress model for oblique turning

International Nuclear Information System (INIS)

Elkhabeery, M. M.

2001-01-01

A proposed mathematical model is presented for predicting the residual stresses caused by turning. Effects of change in tool free length, cutting speed, feed rate, and the tensile strength of work piece material on the maximum residual stress are investigated. The residual stress distribution in the surface region due to turning under unlubricated condition is determined using a deflection etching technique. To reduce the number of experiments required and build the mathematical model for these variables, Response Surface Methodology (RSM) is used. In addition, variance analysis and an experimental check are conducted to determine the prominent parameters and the adequacy of the model. The results show that the tensile stress of the work piece material, cutting speed, and feed rate have significant effects on the maximum residual stresses. The proposed model, that offering good correlation between the experimental and predicted results, is useful in selecting suitable cutting parameters for the machining of different materials. (author)

Abnormal Fear Memory as a Model for Posttraumatic Stress Disorder.

Science.gov (United States)

Desmedt, Aline; Marighetto, Aline; Piazza, Pier-Vincenzo

2015-09-01

For over a century, clinicians have consistently described the paradoxical co-existence in posttraumatic stress disorder (PTSD) of sensory intrusive hypermnesia and declarative amnesia for the same traumatic event. Although this amnesia is considered as a critical etiological factor of the development and/or persistence of PTSD, most current animal models in basic neuroscience have focused exclusively on the hypermnesia, i.e., the persistence of a strong fear memory, neglecting the qualitative alteration of fear memory. The latest is characterized by an underrepresentation of the trauma in the context-based declarative memory system in favor of its overrepresentation in a cue-based sensory/emotional memory system. Combining psychological and neurobiological data as well as theoretical hypotheses, this review supports the idea that contextual amnesia is at the core of PTSD and its persistence and that altered hippocampal-amygdalar interaction may contribute to such pathologic memory. In a first attempt to unveil the neurobiological alterations underlying PTSD-related hypermnesia/amnesia, we describe a recent animal model mimicking in mice some critical aspects of such abnormal fear memory. Finally, this line of argument emphasizes the pressing need for a systematic comparison between normal/adaptive versus abnormal/maladaptive fear memory to identify biomarkers of PTSD while distinguishing them from general stress-related, potentially adaptive, neurobiological alterations. Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Interpretation of metabolic memory phenomenon using a physiological systems model: What drives oxidative stress following glucose normalization?

Science.gov (United States)

Voronova, Veronika; Zhudenkov, Kirill; Helmlinger, Gabriel; Peskov, Kirill

2017-01-01

Hyperglycemia is generally associated with oxidative stress, which plays a key role in diabetes-related complications. A complex, quantitative relationship has been established between glucose levels and oxidative stress, both in vitro and in vivo. For example, oxidative stress is known to persist after glucose normalization, a phenomenon described as metabolic memory. Also, uncontrolled glucose levels appear to be more detrimental to patients with diabetes (non-constant glucose levels) vs. patients with high, constant glucose levels. The objective of the current study was to delineate the mechanisms underlying such behaviors, using a mechanistic physiological systems modeling approach that captures and integrates essential underlying pathophysiological processes. The proposed model was based on a system of ordinary differential equations. It describes the interplay between reactive oxygen species production potential (ROS), ROS-induced cell alterations, and subsequent adaptation mechanisms. Model parameters were calibrated using different sources of experimental information, including ROS production in cell cultures exposed to various concentration profiles of constant and oscillating glucose levels. The model adequately reproduced the ROS excess generation after glucose normalization. Such behavior appeared to be driven by positive feedback regulations between ROS and ROS-induced cell alterations. The further oxidative stress-related detrimental effect as induced by unstable glucose levels can be explained by inability of cells to adapt to dynamic environment. Cell adaptation to instable high glucose declines during glucose normalization phases, and further glucose increase promotes similar or higher oxidative stress. In contrast, gradual ROS production potential decrease, driven by adaptation, is observed in cells exposed to constant high glucose.

Modelling of stresses generated in steels by phase transformations; Modelowanie naprezen wywolanych przemianami fazowymi w stalach

Energy Technology Data Exchange (ETDEWEB)

Dudek, K; Glowacki, M; Pietrzyk, M [Akademia Gorniczo-Hutnicza, Cracow (Poland)

1999-07-01

Numerical model describing stresses arising during phase transformations in steels products is presented. The full model consists of three components. The first component uses finite element solution of Fourier equation for an evaluation of the temperature field inside the sample. The second component predicts kinetics of phase transformation occurring during cooling of steel products. Coupling of these two components allows prediction of structure and properties of final products at room temperature. The third component uses elastic-plastic finite element model for prediction of stresses caused by non-uniform temperatures and by changes of volume during transformations. Typical results of simulations performed for cooling of rails after hot rolling are presented. (author)

Icosahedral symmetry described by an incommensurately modulated crystal structure model

DEFF Research Database (Denmark)

Wolny, Janusz; Lebech, Bente

1986-01-01

A crystal structure model of an incommensurately modulated structure is presented. Although six different reciprocal vectors are used to describe the model, all calculations are done in three dimensions making calculation of the real-space structure trivial. Using this model, it is shown that both...... the positions of the bragg reflections and information about the relative intensities of these reflections are in full accordance with the diffraction patterns reported for microcrystals of the rapidly quenched Al86Mn14 alloy. It is also shown that at least the local structure possesses full icosahedral...

A Model Describing Stable Coherent Synchrotron Radiation in Storage Rings

International Nuclear Information System (INIS)

Sannibale, F.

2004-01-01

We present a model describing high power stable broadband coherent synchrotron radiation (CSR) in the terahertz frequency region in an electron storage ring. The model includes distortion of bunch shape from the synchrotron radiation (SR), which enhances higher frequency coherent emission, and limits to stable emission due to an instability excited by the SR wakefield. It gives a quantitative explanation of several features of the recent observations of CSR at the BESSY II storage ring. We also use this model to optimize the performance of a source for stable CSR emission

A model describing stable coherent synchrotron radiation in storage rings

International Nuclear Information System (INIS)

Sannibale, F.; Byrd, J.M.; Loftsdottir, A.; Venturini, M.; Abo-Bakr, M.; Feikes, J.; Holldack, K.; Kuske, P.; Wuestefeld, G.; Huebers, H.-W.; Warnock, R.

2004-01-01

We present a model describing high power stable broadband coherent synchrotron radiation (CSR) in the terahertz frequency region in an electron storage ring. The model includes distortion of bunch shape from the synchrotron radiation (SR), which enhances higher frequency coherent emission, and limits to stable emission due to an instability excited by the SR wakefield. It gives a quantitative explanation of several features of the recent observations of CSR at the BESSY II storage ring. We also use this model to optimize the performance of a source for stable CSR emission

STRESS MODELING IN COMPOSITE PRODUCTS USING STANDARD OPTICALLY SENSITIVE MATERIAL

Directory of Open Access Journals (Sweden)

Elifkhan K. Agakhanov

2017-01-01

Full Text Available Abstract. Objectives The problem of physically modelling stresses in a compound solid body of revolution having a complex shape and with a complex load distribution is considered. According to the similarity criteria of stress, deformations and displacements from the volume forces decrease proportionally to the scale of similarity of geometric dimensions, which complicates their direct modelling by the photoelasticity method typically using models made from epoxy materials. Methods Based on the principle of the independent action of the forces, the initial problem is represented as the sum of two problems. In the first uniform problem, the stresses in the body of revolution from the centrifugal forces are simulated by the conventional “freezing” method. In order to solve the second nonuniform problem, the stresses in the region of the model, corresponding to the acting centrifugal forces, are “frozen”. The models are glued in a natural state at room temperature, and the compound model is annealed. Results The band patterns in sections as well as components of radial, tangential and axial stresses on contours and in sections of models are obtained by the methods of normal transmission and numerical integration of the equilibrium equation. According to the modelling criteria, the formula for the transition from stresses in models to stresses in the natural structure is established. The results of the analysis of the effect of a body's material density ratio on the stress state of the entire structure are obtained. Conclusion  Axial stresses have insignificant value as compared to radial and tangential stresses; in addition, the ratio of the densities of the compound body has both a quantitative and qualitative influence on the stress state of the structure.

A plastic damage model with stress triaxiality-dependent hardening

International Nuclear Information System (INIS)

Shen Xinpu; Shen Guoxiao; Zhou Lin

2005-01-01

Emphases of this study were placed on the modelling of plastic damage behaviour of prestressed structural concrete, with special attention being paid to the stress-triaxiality dependent plastic hardening law and the corresponding damage evolution law. A definition of stress triaxiality was proposed and introduced in the model presented here. Drucker-Prager -type plasticity was adopted in the formulation of the plastic damage constitutive equations. Numerical validations were performed for the proposed plasticity-based damage model with a driver subroutine developed in this study. The predicted stress-strain behaviour seems reasonably accurate for the uniaxial tension and uniaxial compression compared with the experimental data reported in references. Numerical calculations of compressions under various hydrostatic stress confinements were carried out in order to validate the stress triaxiality dependent properties of the model. (authors)

A model describing water and salt migration in concrete during wetting/drying cycles

NARCIS (Netherlands)

Arends, T.; Taher, A.; van der Zanden, A.J.J.; Brouwers, H.J.H.; Bilek, V.; Kersner, Z.

2014-01-01

In order to predict the life span of concrete structures, models describing the migration of chloride are needed. In this paper, a start is made with a simple, theoretical model describing water and chloride transport in a concrete sample. First, transport of water in concrete is considered with

A model to describe potential effects of chemotherapy on critical radiobiological treatments

Science.gov (United States)

Rodríguez-Pérez, D.; Desco, M. M.; Antoranz, J. C.

2016-08-01

Although chemo- and radiotherapy can annihilate tumors on their own. they are also used in coadjuvancy: improving local effects of radiotherapy using chemotherapy as a radiosensit.izer. The effects of radiotherapy are well described by current radiobiological models. The goal of this work is to describe a discrete radiotherapy model, that has been previously used describe high radiation dose response as well as unusual radio-responses of some types of tumors (e.g. prostate cancer), to obtain a model of chemo+radiotherapy that can describe how the outcome of their combination is a more efficient removal of the tumor. Our hypothesis is that, although both treatments haven different mechanisms, both affect similar key points of cell metabolism and regulation, that lead to cellular death. Hence, we will consider a discrete model where chemotherapy may affect a fraction of the same targets destroyed by radiotherapy. Although radiotherapy reaches all cells equally, chemotherapy diffuses through a tumor attaining lower concentration in its center and higher in its surface. With our simulations we study the enhanced effect of combined therapy treatment and how it depends on the tissue critical parameters (the parameters of the lion-extensive radiobiological model), the number of “targets” aimed at by chemotherapy, and the concentration and diffusion rate of the drug inside the tumor. The results show that an equivalent, cliemo-radio-dose can be computed that allows the prediction of the lower radiation dose that causes the same effect than a radio-only treatment.

Stress distribution in the 16MND5 bainitic steel. Experimental analysis and polycrystalline modelling

International Nuclear Information System (INIS)

Pesci, R.; Inal, K.; Berveiller, M.; Masson, R.

2003-01-01

The 16MND5 bainitic steel being a two-phase material (ferrite/cementite), the X-Ray Diffraction (XRD) is the most efficient tool to determine the stress states into the ferritic phase (sin 2 ψ method). The latter, coupled to the observations realized during tensile tests (specimen surface and facies), have permitted to establish criteria to describe the behavior and the damaging processes of the material on a crystallographic scale, in the lower part of the ductile-to-brittle transition region and at lower temperatures [-196 deg. C;-60 deg. C]. During the loading, the damage is observed with a Scanning Electron Microscope, while the internal stresses are determined by XRD: the stress states are less important in ferrite than in bainite (macroscopic stress), the difference not exceeding 150 MPa. A multi-scale polycrystalline model is developed concurrently with the experimental measurements: a Mori-Tanaka formulation is used to describe the elastoplastic behavior of a ferritic single crystal reinforced by cementite precipitates, while the transition to the polycrystal is achieved by a self-consistent approach. The developed modeling takes into account the temperature effects on the stress states in each phase and includes a cleavage criterion (critical value of the stress normal to [100] planes), which expresses the damage of the material: thus, it enables to predict the actual experimental behavior of the 16MND5 steel in relation to temperature, and to take into account the failure process which is fragile from -120 deg. C. Besides, it is also possible to calculate the strains of the diffracting planes, which can be compared to those measured by XRD: this enables to evaluate the heterogeneity of the strains for each crystallographic orientation. (authors)

A new approach to model strain change of gelled waxy crude oil under constant stress

DEFF Research Database (Denmark)

Hou, Lei; Song, Changyu; Yan, Wei

2014-01-01

Deformation of gelled waxy crude oil with loaded stress is worthy of research for the flow assurance of pipelining system. A dispersion parameter was introduced to characterize the disruption degree of wax crystal structure in crude oil with shear action. Based on fractional calculus theory, a rh...... monotonously with test temperature. Multiple creep curves of gelled waxy crude oil at a certain temperature can be described with this model......., a rheological model incorporating dispersion parameter was proposed to describe creep of gelled waxy crude. A discrete and numerical algorithm was proposed to solve the model. Combining with the experimental results of five kinds of waxy crude oil, the model parameters were regressed and found to change...

An analytical solution describing the shape of a yield stress material subjected to an overpressure

DEFF Research Database (Denmark)

Hovad, Emil; Spangenberg, Jon; Larsen, P.

2016-01-01

as well as the spread length and height of the material when deformed in a box due to gravity. In the present work, the analytical solution is extended with the addition of an overpressure that acts over the entire body of the material. This extension enables finding the shape of a yield stress material......Many fluids and granular materials are able to withstand a limited shear stress without flowing. These materials are known as yields stress materials. Previously, an analytical solution was presented to quantify the yield stress for such materials. The yields stress is obtained based on the density...... with known density and yield stress when for instance deformed under water or subjected to a forced air pressure....

A dependent stress-strength interference model based on mixed copula function

Energy Technology Data Exchange (ETDEWEB)

Gao, Jian Xiong; An, Zong Wen; Liu, Bo [School of Mechatronics Engineering, Lanzhou University of Technology, Lanzhou (China)

2016-10-15

In the traditional Stress-strength interference (SSI) model, stress and strength must satisfy the basic assumption of mutual independence. However, a complex dependence between stress and strength exists in practical engineering. To evaluate structural reliability under the case that stress and strength are dependent, a mixed copula function is introduced to a new dependent SSI model. This model can fully characterize the dependence between stress and strength. The residual square sum method and genetic algorithm are also used to estimate the unknown parameters of the model. Finally, the validity of the proposed model is demonstrated via a practical case. Results show that traditional SSI model ignoring the dependence between stress and strength more easily overestimates product reliability than the new dependent SSI model.

Effective Stress Management: A Model of Emotional Intelligence, Self-Leadership, and Student Stress Coping

Science.gov (United States)

Houghton, Jeffery D.; Wu, Jinpei; Godwin, Jeffrey L.; Neck, Christopher P.; Manz, Charles C.

2012-01-01

This article develops and presents a model of the relationships among emotional intelligence, self-leadership, and stress coping among management students. In short, the authors' model suggests that effective emotion regulation and self-leadership, as mediated through positive affect and self-efficacy, has the potential to facilitate stress coping…

Internal Stress in a Model Elasto-Plastic Fluid

OpenAIRE

Ooshida, Takeshi; Sekimoto, Ken

2004-01-01

Plastic materials can carry memory of past mechanical treatment in the form of internal stress. We introduce a natural definition of the vorticity of internal stress in a simple two-dimensional model of elasto-plastic fluids, which generates the internal stress. We demonstrate how the internal stress is induced under external loading, and how the presence of the internal stress modifies the plastic behavior.

"They have said that I was slightly depressed but there are circumstances that bring that on": How Middle-Aged and Older African American Men Describe Perceived Stress and Depression.

Science.gov (United States)

Cornish, Emily K; Bergner, Erin M; Griffith, Derek M

2017-01-01

Few studies have focused on how men perceive stress and depression, and even fewer have examined how men of a specific racial or ethnic group describe their experiences of these conditions. African American men tend to define health in ways that are inclusive of their physical health, health behaviors, and mental health, but research has largely failed to explore how men put their health and mental health in social contexts. The objective of this article is to explore how middle-aged and older African American men who self-identify as having depression: 1) differentiate stress from depression; and 2) describe depression. Using data from semi-structured, individual interviews conducted between March and April 2014, we used a phenomenological approach to examine how men describe, experience, and perceive stress and depression. Nashville, Tennessee. 18 African American men aged 35-76 years who self-reported a previous or current diagnosis of depression. Men talked about the experiences of stress and how many of them viewed chronic stress as expected and depression as a normal part of life. They used phrases like being "slightly depressed" or "I take a light antidepressant" to describe how they feel and what they are doing to feel better. Within these narratives, men had difficulty distinguishing between stress and depression and they primarily explained that depression was the result of external stressors and strains. Men may have difficulty distinguishing between stress and depression and they may frame the causes of depression in ways that decrease their perceived culpability for its causes and limit their perceived control over the causes of depression.

Predator-based psychosocial stress animal model of PTSD: Preclinical assessment of traumatic stress at cognitive, hormonal, pharmacological, cardiovascular and epigenetic levels of analysis.

Science.gov (United States)

Zoladz, Phillip R; Diamond, David M

2016-10-01

Research on post-traumatic stress disorder (PTSD) is faced with the challenge of understanding how a traumatic experience produces long-lasting detrimental effects on behavior and brain functioning, and more globally, how stress exacerbates somatic disorders, including cardiovascular disease. Moreover, the design of translational research needs to link animal models of PTSD to clinically relevant risk factors which address why only a subset of traumatized individuals develop persistent psychopathology. In this review, we have summarized our psychosocial stress rodent model of PTSD which is based on well-described PTSD-inducing risk factors, including a life-threatening experience, a sense of horror and uncontrollability, and insufficient social support. Specifically, our animal model of PTSD integrates acute episodes of inescapable exposure of immobilized rats to a predator with chronic daily social instability. This stress regimen produces PTSD-like effects in rats at behavioral, cognitive, physiological, pharmacological and epigenetic levels of analysis. We have discussed a recent extension of our animal model of PTSD in which stress exacerbated coronary pathology following an ischemic event, assessed in vitro. In addition, we have reviewed our research investigating pharmacological and non-pharmacological therapeutic strategies which may have value in clinical approaches toward the treatment of traumatized people. Overall, our translational approach bridges the gap between human and animal PTSD research to create a framework with which to enhance our understanding of the biological basis of trauma-induced pathology and to assess therapeutic approaches in the treatment of psychopathology. Copyright © 2016 Elsevier Inc. All rights reserved.

Modeling flow stress constitutive behavior of SA508-3 steel for nuclear reactor pressure vessels

International Nuclear Information System (INIS)

Sun Mingyue; Hao Luhan; Li Shijian; Li Dianzhong; Li Yiyi

2011-01-01

Highlights: → A series of flow stress constitutive equations for SA508-3 steel were successfully established. → The experimental results under different conditions have validated the constitutive equations. → An industrial application of the model was present to simulate a large conical shell forging process. - Abstract: Based on the measured stress-strain curves under different temperatures and strain rates, a series of flow stress constitutive equations for SA508-3 steel were firstly established through the classical theories on work hardening and softening. The comparison between the experimental and modeling results has confirmed that the established constitutive equations can correctly describe the mechanical responses and microstructural evolutions of the steel under various hot deformation conditions. We further represented a successful industrial application of this model to simulate a forging process for a large conical shell used in a nuclear steam generator, which evidences its practical and promising perspective of our model with an aim of widely promoting the hot plasticity processing for heavy nuclear components of fission reactors.

A phenomenological model for pre-stressed piezoelectric ceramic stack actuators

International Nuclear Information System (INIS)

Wang, D H; Zhu, W

2011-01-01

In order to characterize the hysteretic characteristics between the output displacement and applied voltage of pre-stressed piezoelectric ceramic stack actuators (PCSAs), this paper considers that a linear force and a hysteretic force will be generated by a linear extension and a hysteretic extension, respectively, due to the applied voltage to a pre-stressed PCSA and the total force will result in the forced vibration of the single-degree-of-freedom (DOF) system composed of the mass of the pre-stressed PCSA and the equivalent spring and damper of the pre-stressed mechanism, which lets the PCSA be pre-stressed to endure enough tension. On this basis, the phenomenological model to characterize the hysteretic behavior of the pre-stressed PCSA is put forward by using the Bouc–Wen hysteresis operator to model the hysteretic extension. The parameter identification method in a least-squares sense is established by identifying the parameters for the linear and hysteretic components separately with the step and periodic responses of the pre-stressed PCSA, respectively. The performance of the proposed phenomenological model with the corresponding parameter identification method is experimentally verified by the established experimental set-up. The research results show that the phenomenological model for the pre-stressed PCSA with the corresponding parameter identification method can accurately portray the hysteretic characteristics of the pre-stressed PCSA. In addition, the phenomenological model for PCSAs can be deduced from the phenomenological model for pre-stressed PCSAs by removing the terms related to the pre-stressed mechanisms

A model to describe potential effects of chemotherapy on critical radiobiological treatments

International Nuclear Information System (INIS)

Rodríguez-Pérez, D.; Desco, M.M.; Antoranz, J.C.

2016-01-01

Although chemo- and radiotherapy can annihilate tumors on their own. they are also used in coadjuvancy: improving local effects of radiotherapy using chemotherapy as a radiosensit.izer. The effects of radiotherapy are well described by current radiobiological models. The goal of this work is to describe a discrete radiotherapy model, that has been previously used describe high radiation dose response as well as unusual radio-responses of some types of tumors (e.g. prostate cancer), to obtain a model of chemo+radiotherapy that can describe how the outcome of their combination is a more efficient removal of the tumor. Our hypothesis is that, although both treatments haven different mechanisms, both affect similar key points of cell metabolism and regulation, that lead to cellular death. Hence, we will consider a discrete model where chemotherapy may affect a fraction of the same targets destroyed by radiotherapy. Although radiotherapy reaches all cells equally, chemotherapy diffuses through a tumor attaining lower concentration in its center and higher in its surface. With our simulations we study the enhanced effect of combined therapy treatment and how it depends on the tissue critical parameters (the parameters of the lion-extensive radiobiological model), the number of “targets” aimed at by chemotherapy, and the concentration and diffusion rate of the drug inside the tumor. The results show that an equivalent, cliemo-radio-dose can be computed that allows the prediction of the lower radiation dose that causes the same effect than a radio-only treatment. (paper)

An anisotropic thermal-stress model for through-silicon via

Science.gov (United States)

Liu, Song; Shan, Guangbao

2018-02-01

A two-dimensional thermal-stress model of through-silicon via (TSV) is proposed considering the anisotropic elastic property of the silicon substrate. By using the complex variable approach, the distribution of thermal-stress in the substrate can be characterized more accurately. TCAD 3-D simulations are used to verify the model accuracy and well agree with analytical results (model can be integrated into stress-driven design flow for 3-D IC , leading to the more accurate timing analysis considering the thermal-stress effect. Project supported by the Aerospace Advanced Manufacturing Technology Research Joint Fund (No. U1537208).

Endorsement of Models Describing Sexual Response of Men and Women with a Sexual Partner

DEFF Research Database (Denmark)

Giraldi, Annamaria; Kristensen, Ellids; Sand, Michael

2015-01-01

, erectile dysfunction and dissatisfaction with sexual life were significantly related to endorsement of the Basson model or none of the models (P = 0.01). CONCLUSIONS: No single model of sexual response could describe men's and women's sexual responses. The majority of men and women with no sexual......INTRODUCTION: Several models have been used to describe men's and women's sexual responses. These models have been conceptualized as linear or circular models. The circular models were proposed to describe women's sexual function best. AIM: This study aims to determine whether men and women thought...... that current theoretical models of sexual responses accurately reflected their own sexual experience and to what extent this was influenced by sexual dysfunction. METHODS: A cross-sectional study of a large, broadly sampled, nonclinical population, cohort of Danish men and women. The Female Sexual Function...

Simulations of stress-induced twinning and de-twinning: A phase field model

International Nuclear Information System (INIS)

Hu Shenyang; Henager, Chuck H.; Chen Longqing

2010-01-01

Twinning in certain metals or under certain conditions is a major plastic deformation mode. Here we present a phase field model to describe twin formation and evolution in a polycrystalline fcc metal under loading and unloading. The model assumes that twin nucleation, growth and de-twinning is a process of partial dislocation nucleation and slip on successive habit planes. Stacking fault energies, energy pathways (γ surfaces), critical shear stresses for the formation of stacking faults and dislocation core energies are used to construct the thermodynamic model. The simulation results demonstrate that the model is able to predict the nucleation of twins and partial dislocations, as well as the morphology of the twin nuclei, and to reasonably describe twin growth and interaction. The twin microstructures at grain boundaries are in agreement with experimental observation. It was found that de-twinning occurs during unloading in the simulations, however, a strong dependence of twin structure evolution on loading history was observed.

ADAPTATION MODEL FOR REDUCING THE MANAGERIAL STRESS

Directory of Open Access Journals (Sweden)

VIOLETA GLIGOROVSKI

2017-12-01

Full Text Available Changes are an inseparable component of the company's life cycle and they can contribute to its essential growth in the future. The purpose of this paper is to explain managerial stress caused by implementation of changes and creating an adaptation model to decrease managerial stress. How much the manager will successfully lead the project for implementation of a change and how much they will manage to amortize stress among employees, mostly depends on their expertise, knowledge and skills to accurately and comprehensively inform and integrate the employees in the overall process. The adaptation model is actually a new approach and recommendation for managers for dealing with stress when the changes are implemented. Methodology. For this purpose, the data presented, in fact, were collected through a questionnaire that was submitted to 61 respondents/ managers. The data were measured using the Likert scale from 1 to 7. Namely, with the help of the Likert scale, quantification of stress was made in relation to the various variables that were identified as the most important for the researched issues. An adaption model (new approach for amortizing changes was created using the DIA Diagram application, to show the relations between manager and the relevant amortization approaches.

Influence of Hardening Model on Weld Residual Stress Distribution

Energy Technology Data Exchange (ETDEWEB)

Mullins, Jonathan; Gunnars, Jens (Inspecta Technology AB, Stockholm (Sweden))

2009-06-15

This study is the third stage of a project sponsored by the Swedish Radiation Safety Authority (SSM) to improve the weld residual stress modelling procedures currently used in Sweden. The aim of this study was to determine which material hardening model gave the best agreement with experimentally measured weld residual stress distributions. Two girth weld geometries were considered: 19mm and 65mm thick girth welds with Rin/t ratios of 10.5 and 2.8, respectively. The FE solver ABAQUS Standard v6.5 was used for analysis. As a preliminary step some improvements were made to the welding simulation procedure used in part one of the project. First, monotonic stress strain curves and a mixed isotropic/kinematic hardening model were sourced from the literature for 316 stainless steel. Second, more detailed information was obtained regarding the geometry and welding sequence for the Case 1 weld (compared with phase 1 of this project). Following the preliminary step, welding simulations were conducted using isotropic, kinematic and mixed hardening models. The isotropic hardening model gave the best overall agreement with experimental measurements; it is therefore recommended for future use in welding simulations. The mixed hardening model gave good agreement for predictions of the hoop stress but tended to under estimate the magnitude of the axial stress. It must be noted that two different sources of data were used for the isotropic and mixed models in this study and this may have contributed to the discrepancy in predictions. When defining a mixed hardening model it is difficult to delineate the relative contributions of isotropic and kinematic hardening and for the model used it may be that a greater isotropic hardening component should have been specified. The kinematic hardening model consistently underestimated the magnitude of both the axial and hoop stress and is not recommended for use. Two sensitivity studies were also conducted. In the first the effect of using a

Influence of Hardening Model on Weld Residual Stress Distribution

International Nuclear Information System (INIS)

Mullins, Jonathan; Gunnars, Jens

2009-06-01

This study is the third stage of a project sponsored by the Swedish Radiation Safety Authority (SSM) to improve the weld residual stress modelling procedures currently used in Sweden. The aim of this study was to determine which material hardening model gave the best agreement with experimentally measured weld residual stress distributions. Two girth weld geometries were considered: 19mm and 65mm thick girth welds with Rin/t ratios of 10.5 and 2.8, respectively. The FE solver ABAQUS Standard v6.5 was used for analysis. As a preliminary step some improvements were made to the welding simulation procedure used in part one of the project. First, monotonic stress strain curves and a mixed isotropic/kinematic hardening model were sourced from the literature for 316 stainless steel. Second, more detailed information was obtained regarding the geometry and welding sequence for the Case 1 weld (compared with phase 1 of this project). Following the preliminary step, welding simulations were conducted using isotropic, kinematic and mixed hardening models. The isotropic hardening model gave the best overall agreement with experimental measurements; it is therefore recommended for future use in welding simulations. The mixed hardening model gave good agreement for predictions of the hoop stress but tended to under estimate the magnitude of the axial stress. It must be noted that two different sources of data were used for the isotropic and mixed models in this study and this may have contributed to the discrepancy in predictions. When defining a mixed hardening model it is difficult to delineate the relative contributions of isotropic and kinematic hardening and for the model used it may be that a greater isotropic hardening component should have been specified. The kinematic hardening model consistently underestimated the magnitude of both the axial and hoop stress and is not recommended for use. Two sensitivity studies were also conducted. In the first the effect of using a

Ecological and soil hydraulic implications of microbial responses to stress - A modeling analysis

Science.gov (United States)

Brangarí, Albert C.; Fernàndez-Garcia, Daniel; Sanchez-Vila, Xavier; Manzoni, Stefano

2018-06-01

A better understanding of microbial dynamics in porous media may lead to improvements in the design and management of a number of technological applications, ranging from the degradation of contaminants to the optimization of agricultural systems. To this aim, there is a recognized need for predicting the proliferation of soil microbial biomass (often organized in biofilms) under different environments and stresses. We present a general multi-compartment model to account for physiological responses that have been extensively reported in the literature. The model is used as an explorative tool to elucidate the ecological and soil hydraulic consequences of microbial responses, including the production of extracellular polymeric substances (EPS), the induction of cells into dormancy, and the allocation and reuse of resources between biofilm compartments. The mechanistic model is equipped with indicators allowing the microorganisms to monitor environmental and biological factors and react according to the current stress pressures. The feedbacks of biofilm accumulation on the soil water retention are also described. Model runs simulating different degrees of substrate and water shortage show that adaptive responses to the intensity and type of stress provide a clear benefit to microbial colonies. Results also demonstrate that the model may effectively predict qualitative patterns in microbial dynamics supported by empirical evidence, thereby improving our understanding of the effects of pore-scale physiological mechanisms on the soil macroscale phenomena.

Describing Growth Pattern of Bali Cows Using Non-linear Regression Models

Directory of Open Access Journals (Sweden)

Mohd. Hafiz A.W

2016-12-01

Full Text Available The objective of this study was to evaluate the best fit non-linear regression model to describe the growth pattern of Bali cows. Estimates of asymptotic mature weight, rate of maturing and constant of integration were derived from Brody, von Bertalanffy, Gompertz and Logistic models which were fitted to cross-sectional data of body weight taken from 74 Bali cows raised in MARDI Research Station Muadzam Shah Pahang. Coefficient of determination (R2 and residual mean squares (MSE were used to determine the best fit model in describing the growth pattern of Bali cows. Von Bertalanffy model was the best model among the four growth functions evaluated to determine the mature weight of Bali cattle as shown by the highest R2 and lowest MSE values (0.973 and 601.9, respectively, followed by Gompertz (0.972 and 621.2, respectively, Logistic (0.971 and 648.4, respectively and Brody (0.932 and 660.5, respectively models. The correlation between rate of maturing and mature weight was found to be negative in the range of -0.170 to -0.929 for all models, indicating that animals of heavier mature weight had lower rate of maturing. The use of non-linear model could summarize the weight-age relationship into several biologically interpreted parameters compared to the entire lifespan weight-age data points that are difficult and time consuming to interpret.

Stress and sleep reactivity: a prospective investigation of the stress-diathesis model of insomnia.

Science.gov (United States)

Drake, Christopher L; Pillai, Vivek; Roth, Thomas

2014-08-01

To prospectively assess sleep reactivity as a diathesis of insomnia, and to delineate the interaction between this diathesis and naturalistic stress in the development of insomnia among normal sleepers. Longitudinal. Community-based. 2,316 adults from the Evolution of Pathways to Insomnia Cohort (EPIC) with no history of insomnia or depression (46.8 ± 13.2 y; 60% female). None. Participants reported the number of stressful events they encountered at baseline (Time 1), as well as the level of cognitive intrusion they experienced in response to each stressor. Stressful events (OR = 1.13; P stress-induced cognitive intrusion (OR = 1.61; P stressful events on risk for insomnia (P sleep reactivity significantly increased risk for insomnia (OR = 1.78; P sleep reactivity moderated the effects of stress-induced intrusion (P sleep reactivity. Trait sleep reactivity also constituted a significant risk for depression (OR = 1.67; P sleep reactivity is a significant risk factor for incident insomnia, and that it triggers insomnia by exacerbating the effects of stress-induced intrusion. Sleep reactivity is also a precipitant of depression, as mediated by insomnia. These findings support the stress-diathesis model of insomnia, while highlighting sleep reactivity as an important diathesis. Drake CL, Pillai V, Roth T. Stress and sleep reactivity: a prospective investigation of the stress-diathesis model of insomnia.

Porous media fluid flow, heat, and mass transport model with rock stress coupling

International Nuclear Information System (INIS)

Runchal, A.K.

1980-01-01

This paper describes the physical and mathematical basis of a general purpose porous media flow model, GWTHERM. The mathematical basis of the model is obtained from the coupled set of the classical governing equations for the mass, momentum and energy balance. These equations are embodied in a computational model which is then coupled externally to a linearly elastic rock-stress model. This coupling is rather exploratory and based upon empirical correlations. The coupled model is able to take account of time-dependent, inhomogeneous and anisotropic features of the hydrogeologic, thermal and transport phenomena. A number of applications of the model have been made. Illustrations from the application of the model to nuclear waste repositories are included

A model to describe the performance of the UASB reactor.

Science.gov (United States)

Rodríguez-Gómez, Raúl; Renman, Gunno; Moreno, Luis; Liu, Longcheng

2014-04-01

A dynamic model to describe the performance of the Upflow Anaerobic Sludge Blanket (UASB) reactor was developed. It includes dispersion, advection, and reaction terms, as well as the resistances through which the substrate passes before its biotransformation. The UASB reactor is viewed as several continuous stirred tank reactors connected in series. The good agreement between experimental and simulated results shows that the model is able to predict the performance of the UASB reactor (i.e. substrate concentration, biomass concentration, granule size, and height of the sludge bed).

Impact of social stress in addiction to psychostimulants: what we know from animal models.

Science.gov (United States)

Aguilar, Maria A; García-Pardo, Maria P; Montagud-Romero, Sandra; Miñarro, José; Do Couto, Bruno Ribeiro

2013-01-01

Psychostimulant addiction, most notably cocaine and amphetamine - type stimulants are an important public health problem worldwide. It appears that social factors may influence the initiation, maintenance and recovery from addictions. Several animal models have been developed to study addiction, highlighting drug self-administration (SA) and the conditioned place preference (CPP) paradigms. These models have been modified to accurately reflect the characteristics of drug addiction in its different stages. One factor that clearly plays a major role in addiction is stress, which is a risk factor not only for the initiation, maintenance and escalation of drug consumption, but also for relapse. In animal models, stress for itself can provoke reinstatement of self-administration or CPP. The relationship between stress and addiction is very tight. One example is the close anatomical relationship of some areas that share these two phenomena. It seems obvious to think that the main source of stress in humans is social interaction. The aim of the present review is to gather the current information regarding the role of social stress in the addiction to psychostimulant drugs in animal models. First, we briefly describe the mechanisms by which stress exerts its effects and the basic concepts of addiction. We will try to establish common pathways of stress and addiction, to address later social stress effects on different stages of addiction. Then, we will address pharmacological therapies and preventive factors that counteract the enhancing effects of social stress in addiction. Finally, we will analyze how negative environmental conditions may induce individuals to increased vulnerability to drugs, and how favorable environmental conditions may have protective and curative effects against addiction. In this sense, we also analyze the importance of social interactions and their ability to modulate the different stages of addiction. As a conclusion, and despite the scarcity of

Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches.

Science.gov (United States)

Balmus, Ioana Miruna; Ciobica, Alin; Antioch, Iulia; Dobrin, Romeo; Timofte, Daniel

2016-01-01

The correlation between the affective disorders and the almost ubiquitous pathological oxidative stress can be described in a multifactorial way, as an important mechanism of central nervous system impairment. Whether the obvious changes which occur in oxidative balance of the affective disorders are a part of the constitutive mechanism or a collateral effect yet remains as an interesting question. However it is now clear that oxidative stress is a component of these disorders, being characterized by different aspects in a disease-dependent manner. Still, there are a lot of controversies regarding the relevance of the oxidative stress status in most of the affective disorders and despite the fact that most of the studies are showing that the affective disorders development can be correlated to increased oxidative levels, there are various studies stating that oxidative stress is not linked with the mood changing tendencies. Thus, in this minireview we decided to describe the way in which oxidative stress is involved in the affective disorders development, by focusing on the main oxidative stress markers that could be used mechanistically and therapeutically in these deficiencies, the genetic perspectives, some antioxidant approaches, and the relevance of some animal models studies in this context.

A stress driven growth model for soft tissue considering biological availability

International Nuclear Information System (INIS)

Oller, S; Bellomo, F J; Nallim, L G; Armero, F

2010-01-01

Some of the key factors that regulate growth and remodeling of tissues are fundamentally mechanical. However, it is important to take into account the role of bioavailability together with the stresses and strains in the processes of normal or pathological growth. In this sense, the model presented in this work is oriented to describe the growth of soft biological tissue under 'stress driven growth' and depending on the biological availability of the organism. The general theoretical framework is given by a kinematic formulation in large strain combined with the thermodynamic basis of open systems. The formulation uses a multiplicative decomposition of deformation gradient, splitting it in a growth part and visco-elastic part. The strains due to growth are incompatible and are controlled by an unbalanced stresses related to a homeostatic state. Growth implies a volume change with an increase of mass maintaining constant the density. One of the most interesting features of the proposed model is the generation of new tissue taking into account the contribution of mass to the system controlled through biological availability. Because soft biological tissues in general have a hierarchical structure with several components (usually a soft matrix reinforced with collagen fibers), the developed growth model is suitable for the characterization of the growth of each component. This allows considering a different behavior for each of them in the context of a generalized theory of mixtures. Finally, we illustrate the response of the model in case of growth and atrophy with an application example.

Computer modeling describes gravity-related adaptation in cell cultures.

Science.gov (United States)

Alexandrov, Ludmil B; Alexandrova, Stoyana; Usheva, Anny

2009-12-16

Questions about the changes of biological systems in response to hostile environmental factors are important but not easy to answer. Often, the traditional description with differential equations is difficult due to the overwhelming complexity of the living systems. Another way to describe complex systems is by simulating them with phenomenological models such as the well-known evolutionary agent-based model (EABM). Here we developed an EABM to simulate cell colonies as a multi-agent system that adapts to hyper-gravity in starvation conditions. In the model, the cell's heritable characteristics are generated and transferred randomly to offspring cells. After a qualitative validation of the model at normal gravity, we simulate cellular growth in hyper-gravity conditions. The obtained data are consistent with previously confirmed theoretical and experimental findings for bacterial behavior in environmental changes, including the experimental data from the microgravity Atlantis and the Hypergravity 3000 experiments. Our results demonstrate that it is possible to utilize an EABM with realistic qualitative description to examine the effects of hypergravity and starvation on complex cellular entities.

Job stress models for predicting burnout syndrome: a review.

Science.gov (United States)

Chirico, Francesco

2016-01-01

In Europe, the Council Directive 89/391 for improvement of workers' safety and health has emphasized the importance of addressing all occupational risk factors, and hence also psychosocial and organizational risk factors. Nevertheless, the construct of "work-related stress" elaborated from EU-OSHA is not totally corresponding with the "psychosocial" risk, that is a broader category of risk, comprising various and different psychosocial risk factors. The term "burnout", without any binding definition, tries to integrate symptoms as well as cause of the burnout process. In Europe, the most important methods developed for the work related stress risk assessment are based on the Cox's transactional model of job stress. Nevertheless, there are more specific models for predicting burnout syndrome. This literature review provides an overview of job burnout, highlighting the most important models of job burnout, such as the Job Strain, the Effort/Reward Imbalance and the Job Demands-Resources models. The difference between these models and the Cox's model of job stress is explored.

Stress Concentration Factor of Expanded Aluminum Tubes Using Finite Element Modeling

Directory of Open Access Journals (Sweden)

L Mhamdi

2013-06-01

Full Text Available This paper discusses the development of semi-empirical relations for the maximum stress concentration factor (SCF around circular holes embedded in aluminum tubes under various expansion ratios and mandrel angles. Finite element models were developed to study the expansion of a typical aluminum tube with embedded holes of various sizes. An elastic perfectly-plastic material behaviour was used to describe the structural response of the tubes under expansion. Various hole-diameter-to-tubewall- thickness ratios, tube expansion ratios, and mandrel angles were considered to determine the stress state around the hole at zero and 90 degree locations from which the maximum SCF was determined. Semi-empirical relations for the maximum SCF using the Lagrange interpolation formulation were developed. The developed relations were found to predict the SCFs accurately.

Model-based methodology to develop the isochronous stress-strain curves for modified 9Cr steels

International Nuclear Information System (INIS)

Kim, Woo Gon; Yin, Song Nan; Kim, Sung Ho; Lee, Chan Bock; Jung, Ik Hee

2008-01-01

Since high temperature materials are designed with a target life based on a specified amount of allowable strain and stress, their Isochronous Stress-Strain Curves (ISSC) are needed to avoid an excessive deformation during an intended service life. In this paper, a model-based methodology to develop the isochronous curves for a G91 steel is described. Creep strain-time curves were reviewed for typical high-temperature materials, and Garofalo's model which conforms well to the primary and secondary creep stages was proper for the G91 steel. Procedures to obtain an instantaneous elastic-plastic strain, ε i were given in detail. Also, to accurately determine the P 1 , P 2 and P 3 parameters in the Garofalo's model, a Nonlinear Least Square Fitting (NLSF) method was adopted and useful. The long-term creep curves for the G91 steel can be modeled by the Garofalo's model, and the long-term ISSCs can be developed using the modeled creep curves

Gender differences in patient-described pain, stress, and anxiety among patients undergoing treatment for painful conditions in the emergency department.

Science.gov (United States)

Patel, Roma; Biros, Michelle H; Moore, Johanna; Miner, James R

2014-12-01

The primary objective of this study was to determine whether patient-described pain correlates with patient-described stress, anxiety, and satisfaction with ongoing treatment and if that correlation differs by gender. This was a prospective observational study at an urban, Level I trauma center conducted between June 1, 2010, and January 1, 2013. Patients reporting pain rated greater than 3 of 10 were eligible. Patients who qualified and consented for participation completed demographic and pain, anxiety, stress, and satisfaction scales at baseline, every 30 minutes, and at discharge. Data were analyzed using analysis of variance, chi-square tests, t-tests, multiple regression, and the Wilcoxon-Mann-Whitney rank test. A total of 7,124 patients were screened for enrollment. Of those, 3,495 (49%) did not qualify at screening for various reasons, including insufficient pain levels (17.5%), elected not to participate (37.7%), did not qualify for other reasons (12.4%), and reason not captured (32.4%). A total of 3,629 (51%) screened patients were eligible and consented. Of those, 620 (16.8%) did not have any data collected past baseline, leaving 3,009 as the final sample size. The patients completing data collection had a median age of 39 years (range = 18 to 90 years), and 50% were male. The mean presenting pain visual analog scale (VAS) score was 71.5 mm. Presenting stress and anxiety VAS scores were significantly higher in females (0.61 and 0.53, respectively) than males (0.56 and 0.50, respectively), whereas presenting pain VAS (0.71 male and 0.72 female) and satisfaction VAS (0.34 male and 0.35 female) did not differ by sex. Ethnicity, education, and income were all statistically different when compared with baseline pain, stress, anxiety, and satisfaction. Male gender was associated with a significant change in pain over time from baseline (coefficient = 0.040, p = 0.037); however, when adjusting for age, ethnicity, education, and income, and for changes in stress

A two component model describing nucleon structure functions in the low-x region

Energy Technology Data Exchange (ETDEWEB)

Bugaev, E.V. [Institute for Nuclear Research of the Russian Academy of Sciences, 7a, 60th October Anniversary prospect, Moscow 117312 (Russian Federation); Mangazeev, B.V. [Irkutsk State University, 1, Karl Marx Street, Irkutsk 664003 (Russian Federation)

2009-12-15

A two component model describing the electromagnetic nucleon structure functions in the low-x region, based on generalized vector dominance and color dipole approaches is briefly described. The model operates with the mesons of rho-family having the mass spectrum of the form m{sub n}{sup 2}=m{sub r}ho{sup 2}(1+2n) and takes into account the nondiagonal transitions in meson-nucleon scattering. The special cut-off factors are introduced in the model, to exclude the gamma-qq-bar-V transitions in the case of narrow qq-bar-pairs. For the color dipole part of the model the well known FKS-parameterization is used.

Allostatic load: A theoretical model for understanding the relationship between maternal posttraumatic stress disorder and adverse birth outcomes.

Science.gov (United States)

Li, Yang; Rosemberg, Marie-Anne Sanon; Seng, Julia S

2018-07-01

Adverse birth outcomes such as preterm birth and low birth weight are significant public health concerns and contribute to neonatal morbidity and mortality. Studies have increasingly been exploring the predictive effects of maternal posttraumatic stress disorder (PTSD) on adverse birth outcomes. However, the biological mechanisms by which maternal PTSD affects birth outcomes are not well understood. Allostatic load refers to the cumulative dysregulations of the multiple physiological systems as a response to multiple social-ecological levels of chronic stress. Allostatic load has been well documented in relation to both chronic stress and adverse health outcomes in non-pregnant populations. However, the mediating role of allostatic load is less understood when it comes to maternal PTSD and adverse birth outcomes. To propose a theoretical model that depicts how allostatic load could mediate the impact of maternal PTSD on birth outcomes. We followed the procedures for theory synthesis approach described by Walker and Avant (2011), including specifying focal concepts, identifying related factors and relationships, and constructing an integrated representation. We first present a theoretical overview of the allostatic load theory and the other 4 relevant theoretical models. Then we provide a brief narrative review of literature that empirically supports the propositions of the integrated model. Finally, we describe our theoretical model. The theoretical model synthesized has the potential to advance perinatal research by delineating multiple biomarkers to be used in future. After it is well validated, it could be utilized as the theoretical basis for health care professionals to identify high-risk women by evaluating their experiences of psychosocial and traumatic stress and to develop and evaluate service delivery and clinical interventions that might modify maternal perceptions or experiences of stress and eliminate their impacts on adverse birth outcomes. Copyright

Constitutive model for a stress- and thermal-induced phase transition in a shape memory polymer

International Nuclear Information System (INIS)

Guo, Xiaogang; Liu, Liwu; Liu, Yanju; Zhou, Bo; Leng, Jinsong

2014-01-01

Recently, increasing applications of shape memory polymers have pushed forward the development of appropriate constitutive models for smart materials such as the shape memory polymer. During the heating process, the phase transition, which is a continuous time-dependent process, happens in the shape memory polymer, and various individual phases will form at different configuration temperatures. In addition, these phases can generally be divided into two parts: the frozen and active phase (Liu Y et al 2006 Int. J. Plast. 22 279–313). During the heating or cooling process, the strain will be stored or released with the occurring phase transition between these two parts. Therefore, a shape memory effect emerges. In this paper, a new type of model was developed to characterize the variation of the volume fraction in a shape memory polymer during the phase transition. In addition to the temperature variation, the applied stress was also taken as a significant influence factor on the phase transition. Based on the experimental results, an exponential equation was proposed to describe the relationship between the stress and phase transition temperature. For the sake of describing the mechanical behaviors of the shape memory polymer, a three-dimensional constitutive model was established. Also, the storage strain, which was the key factor of the shape memory effect, was also discussed in detail. Similar to previous works, we first explored the effect of applied stress on storage strain. Through comparisons with the DMA and the creep experimental results, the rationality and accuracy of the new phase transition and constitutive model were finally verified. (paper)

Concrete creep and thermal stresses:new creep models and their effects on stress development

OpenAIRE

Westman, Gustaf

1999-01-01

This thesis deals with the problem of creep in concrete and its influence on thermal stress development. New test frames were developed for creep of high performance concrete and for measurements of thermal stress development. Tests were performed on both normal strength and high performance concretes. Two new models for concrete creep are proposed. Firstly, a viscoelastic model, the triple power law, is supplemented with two additional functions for an improved modelling of the early age cre...

Experimental investigation of statistical models describing distribution of counts

International Nuclear Information System (INIS)

Salma, I.; Zemplen-Papp, E.

1992-01-01

The binomial, Poisson and modified Poisson models which are used for describing the statistical nature of the distribution of counts are compared theoretically, and conclusions for application are considered. The validity of the Poisson and the modified Poisson statistical distribution for observing k events in a short time interval is investigated experimentally for various measuring times. The experiments to measure the influence of the significant radioactive decay were performed with 89 Y m (T 1/2 =16.06 s), using a multichannel analyser (4096 channels) in the multiscaling mode. According to the results, Poisson statistics describe the counting experiment for short measuring times (up to T=0.5T 1/2 ) and its application is recommended. However, analysis of the data demonstrated, with confidence, that for long measurements (T≥T 1/2 ) Poisson distribution is not valid and the modified Poisson function is preferable. The practical implications in calculating uncertainties and in optimizing the measuring time are discussed. Differences between the standard deviations evaluated on the basis of the Poisson and binomial models are especially significant for experiments with long measuring time (T/T 1/2 ≥2) and/or large detection efficiency (ε>0.30). Optimization of the measuring time for paired observations yields the same solution for either the binomial or the Poisson distribution. (orig.)

The Culture-Work-Health Model and Work Stress.

Science.gov (United States)

Peterson, Michael; Wilson, John F.

2002-01-01

Examines the role of organizational culture in the etiology of workplace stress through the framework of the Culture-Work- Health model. A review of relevant business and health literature indicates that culture is an important component of work stress and may be a key to creating effective organizational stress interventions. (SM)

An evaluation of a psychosocial stress and coping model in the police work context

Directory of Open Access Journals (Sweden)

Gerrit J. Louw

2010-03-01

Research purpose: The purpose of the study was to determine how Moos's hypothesised stress and coping model (1994 fitted a sample of police officers. Motivation for the study: The study was an attempt to understand police officers' unique needs and how the frequency and/or intensity of perceived stress could be reduced so that they would be able to cope more effectively with stress. Research design, approach and method: A non-experimental survey design, following the quantitative tradition, was used in pursuit of the research objectives. A random sample of 505 participants was extracted from a population of serving male and female police officers reflecting the typical South African ethnic groups. Structural equation modelling (SEM was used to establish the adequacy of between the hypothesised Moos model and the sample. Main findings: The hypothesised theoretical framework was disproved. A respecified model and inter-correlations confirm that some officers experience burnout, while, paradoxically, others continue to be unaffected because of the buffering effect of social support, personality factors and other resilience factors not revealed in this study. Practical/managerial implications: The study calls on police management for awareness of the negative health consequences of prolonged stressors. Simultaneously, employee assistance programmes could be directed to problem-solving strategies, perceived self-efficacy and learned resourcefulness to improve control over prolonged negative stress consequences among members. Contribution/value-add: This research provides a theoretical framework to understand, describe and assess individual well-being in the police work context.

Conceptual hierarchical modeling to describe wetland plant community organization

Science.gov (United States)

Little, A.M.; Guntenspergen, G.R.; Allen, T.F.H.

2010-01-01

Using multivariate analysis, we created a hierarchical modeling process that describes how differently-scaled environmental factors interact to affect wetland-scale plant community organization in a system of small, isolated wetlands on Mount Desert Island, Maine. We followed the procedure: 1) delineate wetland groups using cluster analysis, 2) identify differently scaled environmental gradients using non-metric multidimensional scaling, 3) order gradient hierarchical levels according to spatiotem-poral scale of fluctuation, and 4) assemble hierarchical model using group relationships with ordination axes and post-hoc tests of environmental differences. Using this process, we determined 1) large wetland size and poor surface water chemistry led to the development of shrub fen wetland vegetation, 2) Sphagnum and water chemistry differences affected fen vs. marsh / sedge meadows status within small wetlands, and 3) small-scale hydrologic differences explained transitions between forested vs. non-forested and marsh vs. sedge meadow vegetation. This hierarchical modeling process can help explain how upper level contextual processes constrain biotic community response to lower-level environmental changes. It creates models with more nuanced spatiotemporal complexity than classification and regression tree procedures. Using this process, wetland scientists will be able to generate more generalizable theories of plant community organization, and useful management models. ?? Society of Wetland Scientists 2009.

Relations of occupational stress to occupational class in Japanese civil servants : analysis by two occupational stress models

OpenAIRE

Kawaharada, Mariko; Saijo, Yasuaki; Yoshioka, Eiji; Sato, Tetsuro; Sato, Hirokazu; Kishi, Reiko

2007-01-01

The aim of the present study was to identify relations between occupational stress and occupational class in Japanese civil servants, using two occupational stress models – the Effort-Reward Imbalance (ERI) Model and the Job Demand-Control (JDC) Model. The subjects were employees of three local public organizations. We distributed self-administered questionnaires and assessed occupational stress by ERI and JDC. We used seven occupational categories based on the Standard Occupational Classific...

An algebraic stress/flux model for two-phase turbulent flow

International Nuclear Information System (INIS)

Kumar, R.

1995-12-01

An algebraic stress model (ASM) for turbulent Reynolds stress and a flux model for turbulent heat flux are proposed for two-phase bubbly and slug flows. These mathematical models are derived from the two-phase transport equations for Reynolds stress and turbulent heat flux, and provide C μ , a turbulent constant which defines the level of eddy viscosity, as a function of the interfacial terms. These models also include the effect of heat transfer. When the interfacial drag terms and the interfacial momentum transfer terms are absent, the model reduces to a single-phase model used in the literature

Evaluation of Full Reynolds Stress Turbulence Models in FUN3D

Science.gov (United States)

Dudek, Julianne C.; Carlson, Jan-Renee

2017-01-01

Full seven-equation Reynolds stress turbulence models are a relatively new and promising tool for todays aerospace technology challenges. This paper uses two stress-omega full Reynolds stress models to evaluate challenging flows including shock-wave boundary layer interactions, separation and mixing layers. The Wilcox and the SSGLRR full second-moment Reynolds stress models are evaluated for four problems: a transonic two-dimensional diffuser, a supersonic axisymmetric compression corner, a compressible planar shear layer, and a subsonic axisymmetric jet. Simulation results are compared with experimental data and results using the more commonly used Spalart-Allmaras (SA) one-equation and the Menter Shear Stress Transport (SST) two-equation models.

Feasibility study for a plasticity model to describe the transient thermomechanical behavior of Zircaloy. Final report

International Nuclear Information System (INIS)

Valanis, K.C.

1979-11-01

The conceptual framework of the endochronic theory is described and a summary of its capabilities, as well as past and potential applications to the mechanical response of metals to general histories of deformation, temperature, and radiation is given. The purely mechanical part of the theory is developed on the basis of the concept of intrinsic time which serves to incorporate in a unified and concise fashion the effects of strain history and strain rate on the stress response. The effects of temperature are introduced by means of the theory of deformation kinetics through its relation to the internal variable theory of irreversible thermodynamics. As a result, physically sound formulae are developed which account for the effect of temperature history on the stress response. An approach to describing irradiation effects is briefly discussed. More research would be needed to define appropriate constitutive representations for Zircaloy. The endochronic theory is also looked at from a numerical analysis viewpoint of future applications to problems of practical interest. In appendix B a first cut attempt has been made to assess the computational efficiencies of material constitutive equation approaches

Examining the intersection of sex and stress in modelling neuropsychiatric disorders.

Science.gov (United States)

Goel, N; Bale, T L

2009-03-01

Sex-biased neuropsychiatric disorders, including major depressive disorder and schizophrenia, are the major cause of disability in the developed world. Elevated stress sensitivity has been proposed as a key underlying factor in disease onset. Sex differences in stress sensitivity are associated with corticotrophin-releasing factor (CRF) and serotonin neurotransmission, which are important central regulators of mood and coping responses. To elucidate the underlying neurobiology of stress-related disease predisposition, it is critical to develop appropriate animal models of stress pathway dysregulation. Furthermore, the inclusion of sex difference comparisons in stress responsive behaviours, physiology and central stress pathway maturation in these models is essential. Recent studies by our laboratory and others have begun to investigate the intersection of stress and sex where the development of mouse models of stress pathway dysregulation via prenatal stress experience or early-life manipulations has provided insight into points of developmental vulnerability. In addition, examination of the maturation of these pathways, including the functional importance of the organisational and activational effects of gonadal hormones on stress responsivity, is essential for determination of when sex differences in stress sensitivity may begin. In such studies, we have detected distinct sex differences in stress coping strategies where activational effects of testosterone produced females that displayed male-like strategies in tests of passive coping, but were similar to females in tests of active coping. In a second model of elevated stress sensitivity, male mice experiencing prenatal stress early in gestation showed feminised physiological and behavioural stress responses, and were highly sensitive to a low dose of selective serotonin reuptake inhibitors. Analyses of expression and epigenetic patterns revealed changes in CRF and glucocorticoid receptor genes in these mice

Examining the intersection of sex and stress in modeling neuropsychiatric disorders

Science.gov (United States)

Goel, Nirupa; Bale, Tracy L.

2009-01-01

Sex-biased neuropsychiatric disorders, including major depressive disorder and schizophrenia, are the major cause of disability in the developed world. Elevated stress sensitivity has been proposed as a key underlying factor in disease onset. Sex differences in stress sensitivity are associated with CRF and serotonin neurotransmission, important central regulators of mood and coping responses. To elucidate the underlying neurobiology of stress-related disease predisposition, it is critical to develop appropriate animal models of stress pathway dysregulation. Further, the inclusion of sex difference comparisons in stress responsive behaviors, physiology, and central stress pathway maturation in these models is essential. Recent studies by our lab and others have begun to investigate the intersection of stress and sex where the development of mouse models of stress pathway dysregulation via prenatal stress experience or early life manipulations has provided insight into points of developmental vulnerability. In addition, examination of the maturation of these pathways including the functional importance of the organizational and activational effects of gonadal hormones on stress responsivity is essential for determination of when sex differences in stress sensitivity may begin. In such studies, we have detected distinct sex differences in stress coping strategies where activational effects of testosterone produced females that displayed male-like strategies in tests of passive coping, but were similar to females in tests of active coping. In a second model of elevated stress sensitivity, male mice experiencing prenatal stress early in gestation showed feminized physiological and behavioral stress responses, and were highly sensitive to a low dose of SSRI. Analyses of expression and epigenetic patterns revealed changes in CRF and glucocorticoid receptor genes in these mice. Mechanistically, stress early in pregnancy produced a significant sex-dependent effect on

Describing the processes of propagation and eliminating wildfires with the use of agent models

Directory of Open Access Journals (Sweden)

G. A. Dorrer

2017-10-01

Full Text Available A new method of describing the processes of propagation and elimination of wildfires on the basis of agent-based modeling is proposed. The main structural units of the creation of such models are the classes of active objects (agents. Agent approach, combined with Geographic Information Systems (GIS can effectively describe the interaction of a large number of participants in the process to combat wildfires: fire spreading, fire crews, mechanization, aerial means and other. In this paper we propose a multi-agent model to predict the spread of wildfire edge and simulate the direct method of extinguishing a ground fire with non-mechanized crews. The model consist with two classes of agents, designated A and B. The burning fire edge is represented as a chain of A-agents, each of which simulates the burning of an elementary portion of vegetation fuel. Fire front movement (moving the A-agent described by the Hamilton-Jacobi equation with using the indicatrises of normal front rate of spread (figurotris. The configuration of the front calculated on basis the algorithm of mobile grids. Agents other type, B-agents, described extinguishing process; they move to the agents of A type and act on them, reducing the combustion intensity to zero. Modeling system presented as two-level coloured nested Petri Net, which describes the agents’ interaction semantics. This model is implemented as a GIS-oriented software system that can be useful both in the fire fighting management as well as in staff training tactics to fighting wildfires. Some examples of modeling decision making on а ground fire extinguishing are presented.

Normal stresses in semiflexible polymer hydrogels

Science.gov (United States)

Vahabi, M.; Vos, Bart E.; de Cagny, Henri C. G.; Bonn, Daniel; Koenderink, Gijsje H.; MacKintosh, F. C.

2018-03-01

Biopolymer gels such as fibrin and collagen networks are known to develop tensile axial stress when subject to torsion. This negative normal stress is opposite to the classical Poynting effect observed for most elastic solids including synthetic polymer gels, where torsion provokes a positive normal stress. As shown recently, this anomalous behavior in fibrin gels depends on the open, porous network structure of biopolymer gels, which facilitates interstitial fluid flow during shear and can be described by a phenomenological two-fluid model with viscous coupling between network and solvent. Here we extend this model and develop a microscopic model for the individual diagonal components of the stress tensor that determine the axial response of semiflexible polymer hydrogels. This microscopic model predicts that the magnitude of these stress components depends inversely on the characteristic strain for the onset of nonlinear shear stress, which we confirm experimentally by shear rheometry on fibrin gels. Moreover, our model predicts a transient behavior of the normal stress, which is in excellent agreement with the full time-dependent normal stress we measure.

Chronic stress impacts the cardiovascular system: animal models and clinical outcomes.

Science.gov (United States)

Golbidi, Saeid; Frisbee, Jefferson C; Laher, Ismail

2015-06-15

Psychological stresses are associated with cardiovascular diseases to the extent that cardiovascular diseases are among the most important group of psychosomatic diseases. The longstanding association between stress and cardiovascular disease exists despite a large ambiguity about the underlying mechanisms. An array of possibilities have been proposed including overactivity of the autonomic nervous system and humoral changes, which then converge on endothelial dysfunction that initiates unwanted cardiovascular consequences. We review some of the features of the two most important stress-activated systems, i.e., the humoral and nervous systems, and focus on alterations in endothelial function that could ensue as a result of these changes. Cardiac and hematologic consequences of stress are also addressed briefly. It is likely that activation of the inflammatory cascade in association with oxidative imbalance represents key pathophysiological components of stress-induced cardiovascular changes. We also review some of the commonly used animal models of stress and discuss the cardiovascular outcomes reported in these models of stress. The unique ability of animals for adaptation under stressful conditions lessens the extrapolation of laboratory findings to conditions of human stress. An animal model of unpredictable chronic stress, which applies various stress modules in a random fashion, might be a useful solution to this predicament. The use of stress markers as indicators of stress intensity is also discussed in various models of animal stress and in clinical studies. Copyright © 2015 the American Physiological Society.

A consilience model to describe N2O production during biological N removal

DEFF Research Database (Denmark)

Domingo Felez, Carlos; Smets, Barth F.

2016-01-01

Nitrous oxide (N2O), a potent greenhouse gas, is produced during biological nitrogen conversion in wastewater treatment operations. Complex mechanisms underlie N2O production by autotrophic and heterotrophic organisms, which continue to be unravelled. Mathematical models that describe nitric oxide...... (NO) and N2O dynamics have been proposed. Here, a first comprehensive model that considers all relevant NO and N2O production and consumption mechanisms is proposed. The model describes autotrophic NO production by ammonia oxidizing bacteria associated with ammonia oxidation and with nitrite reduction......, followed by NO reduction to N2O. It also considers NO and N2O as intermediates in heterotrophic denitrification in a 4-step model. Three biological NO and N2O production pathways are accounted for, improving the capabilities of existing models while not increasing their complexity. Abiotic contributions...

Do maize models capture the impacts of heat and drought stresses on yield? Using algorithm ensembles to identify successful approaches.

Science.gov (United States)

Jin, Zhenong; Zhuang, Qianlai; Tan, Zeli; Dukes, Jeffrey S; Zheng, Bangyou; Melillo, Jerry M

2016-09-01

Stresses from heat and drought are expected to increasingly suppress crop yields, but the degree to which current models can represent these effects is uncertain. Here we evaluate the algorithms that determine impacts of heat and drought stress on maize in 16 major maize models by incorporating these algorithms into a standard model, the Agricultural Production Systems sIMulator (APSIM), and running an ensemble of simulations. Although both daily mean temperature and daylight temperature are common choice of forcing heat stress algorithms, current parameterizations in most models favor the use of daylight temperature even though the algorithm was designed for daily mean temperature. Different drought algorithms (i.e., a function of soil water content, of soil water supply to demand ratio, and of actual to potential transpiration ratio) simulated considerably different patterns of water shortage over the growing season, but nonetheless predicted similar decreases in annual yield. Using the selected combination of algorithms, our simulations show that maize yield reduction was more sensitive to drought stress than to heat stress for the US Midwest since the 1980s, and this pattern will continue under future scenarios; the influence of excessive heat will become increasingly prominent by the late 21st century. Our review of algorithms in 16 crop models suggests that the impacts of heat and drought stress on plant yield can be best described by crop models that: (i) incorporate event-based descriptions of heat and drought stress, (ii) consider the effects of nighttime warming, and (iii) coordinate the interactions among multiple stresses. Our study identifies the proficiency with which different model formulations capture the impacts of heat and drought stress on maize biomass and yield production. The framework presented here can be applied to other modeled processes and used to improve yield predictions of other crops with a wide variety of crop models. © 2016 John

The γ-ε martensitic transformation: a model for stress induced variant and its interaction with grain boundary

International Nuclear Information System (INIS)

Guenin, G.

1995-01-01

The γ (f.c.c.) to ε (h.c.p.) martensitic transformation occurs through the Shockley a/6 left angle 211 right angle faulting every second {111} plane of the f.c.c. structure. A stress induced thin single variant corresponds to a single a/6 left angle 211 right angle faulting vector and leads to a large homogeneous shear (0.35) in amplitude. The tip of such a plate is composed of a set of identical Shockley partial dislocations with large mutual interactions. This work is a presentation of a model which describes the martensite morphology of stress induced ε martensite in shape memory Fe-Mn-Si based alloys. The model includes the formation mechanism of the plate (Seeger's like) and its growth inside a limited grain. The mutual interaction of Shockley dislocations and their interaction with the grain boundary is semi quantitatively described; it leads to a lenticular shape of ε martensite thin plates. The model is able to explain the behaviour of this kind of alloys concerning the superelastic effect and the shape memory. (orig.)

Can the "standard" unitarized Regge models describe the TOTEM data?

CERN Document Server

Alkin, A; Martynov, E

2013-01-01

The standard Regge poles are considered as inputs for two unitarization methods: eikonal and U-matrix. It is shown that only models with three input pomerons and two input odderons can describe the high energy data on $pp$ and $\\bar pp$ elastic scattering including the new data from Tevatron and LHC. However, it seems that the both considered models require a further modification (e.g. nonlinear reggeon trajectories and/or nonexponential vertex functions) for a more satisfactory description of the data at 19.0 GeV$\\leq \\sqrt{s}\\leq$ 7 TeV and 0.01 $\\leq |t|\\leq $14.2 GeV$^{2}$.

A statistical model describing combined irreversible electroporation and electroporation-induced blood-brain barrier disruption.

Science.gov (United States)

Sharabi, Shirley; Kos, Bor; Last, David; Guez, David; Daniels, Dianne; Harnof, Sagi; Mardor, Yael; Miklavcic, Damijan

2016-03-01

Electroporation-based therapies such as electrochemotherapy (ECT) and irreversible electroporation (IRE) are emerging as promising tools for treatment of tumors. When applied to the brain, electroporation can also induce transient blood-brain-barrier (BBB) disruption in volumes extending beyond IRE, thus enabling efficient drug penetration. The main objective of this study was to develop a statistical model predicting cell death and BBB disruption induced by electroporation. This model can be used for individual treatment planning. Cell death and BBB disruption models were developed based on the Peleg-Fermi model in combination with numerical models of the electric field. The model calculates the electric field thresholds for cell kill and BBB disruption and describes the dependence on the number of treatment pulses. The model was validated using in vivo experimental data consisting of rats brains MRIs post electroporation treatments. Linear regression analysis confirmed that the model described the IRE and BBB disruption volumes as a function of treatment pulses number (r(2) = 0.79; p disruption, the ratio increased with the number of pulses. BBB disruption radii were on average 67% ± 11% larger than IRE volumes. The statistical model can be used to describe the dependence of treatment-effects on the number of pulses independent of the experimental setup.

Numerical modeling of injection, stress and permeability enhancement during shear stimulation at the Desert Peak Enhanced Geothermal System

Science.gov (United States)

Dempsey, David; Kelkar, Sharad; Davatzes, Nick; Hickman, Stephen H.; Moos, Daniel

2015-01-01

Creation of an Enhanced Geothermal System relies on stimulation of fracture permeability through self-propping shear failure that creates a complex fracture network with high surface area for efficient heat transfer. In 2010, shear stimulation was carried out in well 27-15 at Desert Peak geothermal field, Nevada, by injecting cold water at pressure less than the minimum principal stress. An order-of-magnitude improvement in well injectivity was recorded. Here, we describe a numerical model that accounts for injection-induced stress changes and permeability enhancement during this stimulation. In a two-part study, we use the coupled thermo-hydrological-mechanical simulator FEHM to: (i) construct a wellbore model for non-steady bottom-hole temperature and pressure conditions during the injection, and (ii) apply these pressures and temperatures as a source term in a numerical model of the stimulation. In this model, a Mohr-Coulomb failure criterion and empirical fracture permeability is developed to describe permeability evolution of the fractured rock. The numerical model is calibrated using laboratory measurements of material properties on representative core samples and wellhead records of injection pressure and mass flow during the shear stimulation. The model captures both the absence of stimulation at low wellhead pressure (WHP ≤1.7 and ≤2.4 MPa) as well as the timing and magnitude of injectivity rise at medium WHP (3.1 MPa). Results indicate that thermoelastic effects near the wellbore and the associated non-local stresses further from the well combine to propagate a failure front away from the injection well. Elevated WHP promotes failure, increases the injection rate, and cools the wellbore; however, as the overpressure drops off with distance, thermal and non-local stresses play an ongoing role in promoting shear failure at increasing distance from the well.

A relation to describe rate-dependent material failure.

Science.gov (United States)

Voight, B

1989-01-13

The simple relation OmegaOmega-alpha = 0, where Omega is a measurable quantity such as strain and A and alpha are empirical constants, describes the behavior of materials in terminal stages of failure under conditions of approximately constant stress and temperature. Applicable to metals and alloys, ice, concrete, polymers, rock, and soil, the relation may be extended to conditions of variable and multiaxial stress and may be used to predict time to failure.

A structural model of the dimensions of teacher stress.

Science.gov (United States)

Boyle, G J; Borg, M G; Falzon, J M; Baglioni, A J

1995-03-01

A comprehensive survey of teacher stress, job satisfaction and career commitment among 710 full-time primary school teachers was undertaken by Borg, Riding & Falzon (1991) in the Mediterranean islands of Malta and Gozo. A principal components analysis of a 20-item sources of teacher stress inventory had suggested four distinct dimensions which were labelled: Pupil Misbehaviour, Time/Resource Difficulties, Professional Recognition Needs, and Poor Relationships, respectively. To check on the validity of the Borg et al. factor solution, the group of 710 teachers was randomly split into two separate samples. Exploratory factor analysis was carried out on the data from Sample 1 (N = 335), while Sample 2 (N = 375) provided the cross-validational data for a LISREL confirmatory factor analysis. Results supported the proposed dimensionality of the sources of teacher stress (measurement model), along with evidence of an additional teacher stress factor (Workload). Consequently, structural modelling of the 'causal relationships' between the various latent variables and self-reported stress was undertaken on the combined samples (N = 710). Although both non-recursive and recursive models incorporating Poor Colleague Relations as a mediating variable were tested for their goodness-of-fit, a simple regression model provided the most parsimonious fit to the empirical data, wherein Workload and Student Misbehaviour accounted for most of the variance in predicting teaching stress.

Stress and Sleep Reactivity: A Prospective Investigation of the Stress-Diathesis Model of Insomnia

Science.gov (United States)

Drake, Christopher L.; Pillai, Vivek; Roth, Thomas

2014-01-01

Study Objectives: To prospectively assess sleep reactivity as a diathesis of insomnia, and to delineate the interaction between this diathesis and naturalistic stress in the development of insomnia among normal sleepers. Design: Longitudinal. Setting: Community-based. Participants: 2,316 adults from the Evolution of Pathways to Insomnia Cohort (EPIC) with no history of insomnia or depression (46.8 ± 13.2 y; 60% female). Interventions: None. Measurements and Results: Participants reported the number of stressful events they encountered at baseline (Time 1), as well as the level of cognitive intrusion they experienced in response to each stressor. Stressful events (OR = 1.13; P insomnia one year hence (Time 2). Intrusion mediated the effects of stressful events on risk for insomnia (P insomnia (OR = 1.78; P insomnia as a function of intrusion was significantly higher in individuals with high sleep reactivity. Trait sleep reactivity also constituted a significant risk for depression (OR = 1.67; P Insomnia at Time 2 significantly mediated this effect (P insomnia, and that it triggers insomnia by exacerbating the effects of stress-induced intrusion. Sleep reactivity is also a precipitant of depression, as mediated by insomnia. These findings support the stress-diathesis model of insomnia, while highlighting sleep reactivity as an important diathesis. Citation: Drake CL, Pillai V, Roth T. Stress and sleep reactivity: a prospective investigation of the stress-diathesis model of insomnia. SLEEP 2014;37(8):1295-1304. PMID:25083009

Coupling biochemistry and mechanics in cell adhesion: a model for inhomogeneous stress fiber contraction

International Nuclear Information System (INIS)

Besser, Achim; Schwarz, Ulrich S

2007-01-01

Biochemistry and mechanics are closely coupled in cell adhesion. At sites of cell-matrix adhesion, mechanical force triggers signaling through the Rho-pathway, which leads to structural reinforcement and increased contractility in the actin cytoskeleton. The resulting force acts back to the sites of adhesion, resulting in a positive feedback loop for mature adhesion. Here, we model this biochemical-mechanical feedback loop for the special case when the actin cytoskeleton is organized in stress fibers, which are contractile bundles of actin filaments. Activation of myosin II molecular motors through the Rho-pathway is described by a system of reaction-diffusion equations, which are coupled into a viscoelastic model for a contractile actin bundle. We find strong spatial gradients in the activation of contractility and in the corresponding deformation pattern of the stress fiber, in good agreement with experimental findings

An analytical mechanical model to describe the response of NiTi rotary endodontic files in a curved root canal.

Science.gov (United States)

Leroy, Agnès Marie Françoise; Bahia, Maria Guiomar de Azevedo; Ehrlacher, Alain; Buono, Vicente Tadeu Lopes

2012-08-01

To build a mathematical model describing the mechanical behavior of NiTi rotary files while they are rotating in a root canal. The file was seen as a beam undergoing large transformations. The instrument was assumed to be rotating steadily in the root canal, and the geometry of the canal was considered as a known parameter of the problem. The formulae of large transformations mechanics then allowed the calculation of the Green-Lagrange strain field in the file. The non-linear mechanical behavior of NiTi was modeled as a continuous piecewise linear function, assuming that the material did not reach plastic deformation. Criteria locating the changes of behavior of NiTi were established and the tension field in the file, and the external efforts applied on it were calculated. The unknown variable of torsion was deduced from the equilibrium equation system using a Coulomb contact law which solved the problem on a cycle of rotation. In order to verify that the model described well reality, three-point bending experiments were managed on superelastic NiTi wires, whose results were compared to the theoretical ones. It appeared that the model gave a good mentoring of the empirical results in the range of bending angles that interested us. Knowing the geometry of the root canal, one is now able to write the equations of the strain and stress fields in the endodontic instrument, and to quantify the impact of each macroscopic parameter of the problem on its response. This should be useful to predict failure of the files under rotating bending fatigue, and to optimize the geometry of the files. Copyright © 2012 Elsevier B.V. All rights reserved.

Vicarious social defeat stress: Bridging the gap between physical and emotional stress.

Science.gov (United States)

Sial, Omar K; Warren, Brandon L; Alcantara, Lyonna F; Parise, Eric M; Bolaños-Guzmán, Carlos A

2016-01-30

Animal models capable of differentiating the neurobiological intricacies between physical and emotional stress are scarce. Current models rely primarily on physical stressors (e.g., chronic unpredictable or mild stress, social defeat, learned helplessness), and neglect the impact of psychological stress alone. This is surprising given extensive evidence that a traumatic event needs not be directly experienced to produce enduring perturbations on an individual's health and psychological well-being. Post-traumatic stress disorder (PTSD), a highly debilitating neuropsychiatric disorder characterized by intense fear of trauma-related stimuli, often occurs in individuals that have only witnessed a traumatic event. By modifying the chronic social defeat stress (CSDS) paradigm to include a witness component (witnessing the social defeat of another mouse), we demonstrate a novel behavioral paradigm capable of inducing a robust behavioral syndrome reminiscent of PTSD in emotionally stressed adult mice. We describe the vicarious social defeat stress (VSDS) model that is capable of inducing a host of behavioral deficits that include social avoidance and other depressive- and anxiety-like phenotypes in adult male mice. VSDS exposure induces weight loss and spike in serum corticosterone (CORT) levels. A month after stress, these mice retain the social avoidant phenotype and have an increased CORT response when exposed to subsequent stress. The VSDS is a novel paradigm capable of inducing emotional stress by isolating physical stress/confrontation in mice. The VSDS model can be used to study the short- and long-term neurobiological consequences of exposure to emotional stress in mice. Copyright © 2015 Elsevier B.V. All rights reserved.

Modeling of stresses at grain boundaries with respect to occurrence of stress corrosion cracking

Energy Technology Data Exchange (ETDEWEB)

Kozaczek, K.J. [Oak Ridge National Lab., TN (United States); Sinharoy, A.; Ruud, C.O. [Pennsylvania State Univ., University Park, PA (United States); McIlree, A.R. [Electric Power Research Institute, Palo Alto, CA (United States)

1995-12-31

The distributions of elastic stresses/strains in the grain boundary regions were studied by the analytical and the finite element models. The grain boundaries represent the sites where stress concentration occurs as a result of discontinuity of elastic properties across the grain boundary and the presence of second phase particles elastically different from the surrounding matrix grains. A quantitative analysis of those stresses for steels and nickel based alloys showed that the stress concentrations in the grain boundary regions are high enough to cause a local microplastic deformation even when the material is in the macroscopic elastic regime. The stress redistribution as a result of such a plastic deformation was discussed.

Teacher stress and health; examination of a model.

Science.gov (United States)

DeFrank, R S; Stroup, C A

1989-01-01

Stress in teaching derives from a variety of sources, and evidence exists linking such stress to physical and mental health concerns. Detailed examination of the linkages among personal factors, job stress, job satisfaction and symptomatology have not been done in this occupation, however, and the present study examines a model interrelating these variables. A survey of 245 predominantly female elementary school teachers in southeast Texas suggested that demographic factors and teaching background do not influence stress, satisfaction or health concerns. However, while job stress was the strongest predictor of job satisfaction, this stress had no direct relationship with health problems, an unexpected finding. Write-in responses by teachers indicated additional sources of stress, many of which were environmental or policy-based in nature. The implications of these findings for future research and stress management interventions for teachers are discussed.

Integrity: A semi-mechanistic model for stress corrosion cracking of fuel

Energy Technology Data Exchange (ETDEWEB)

Tayal, M; Hallgrimson, K; Macquarrie, J; Alavi, P [Atomic Energy of Canada Ltd., Mississauga, ON (Canada); Sato, S; Kinoshita, Y; Nishimura, T [Electric Power Development Co. Ltd., Tokyo (Japan)

1997-08-01

In this paper we describe the features, validation, and illustrative applications of a semi-mechanistic model, INTEGRITY, which calculates the probability of fuel defects due to stress corrosion cracking. The model expresses the defect probability in terms of fundamental parameters such as local stresses, local strains, and fission product concentration. The assessments of defect probability continue to reflect the influence of conventional parameters like ramped power, power-ramp, burnup and Canlub coating. In addition, the INTEGRITY model provides a mechanism to account for the impacts of additional factors involving detailed fuel design and reactor operation. Some examples of the latter include pellet density, pellet shape and size, sheath diameter and thickness, pellet/sheath clearance, coolant temperature and pressure, etc. The model has been fitted to a database of 554 power-ramp irradiations of CANDU fuel with and without Canlub. For this database the INTEGRITY model calculates 75 defects vs 75 actual defects. Similarly good agreements were noted in the different sub-groups of the data involving non-Canlub, thin-Canlub, and thick-Canlub fuel. Moreover, the shapes and the locations of the defect thresholds were consistent with all the above defects as well as with additional 14 ripple defects that were not in the above database. Two illustrative examples demonstrate how the defect thresholds are influenced by changes in the internal design of the fuel element and by extended burnup. (author). 19 refs, 7 figs.

Integrity: A semi-mechanistic model for stress corrosion cracking of fuel

International Nuclear Information System (INIS)

Tayal, M.; Hallgrimson, K.; Macquarrie, J.; Alavi, P.; Sato, S.; Kinoshita, Y.; Nishimura, T.

1997-01-01

In this paper we describe the features, validation, and illustrative applications of a semi-mechanistic model, INTEGRITY, which calculates the probability of fuel defects due to stress corrosion cracking. The model expresses the defect probability in terms of fundamental parameters such as local stresses, local strains, and fission product concentration. The assessments of defect probability continue to reflect the influence of conventional parameters like ramped power, power-ramp, burnup and Canlub coating. In addition, the INTEGRITY model provides a mechanism to account for the impacts of additional factors involving detailed fuel design and reactor operation. Some examples of the latter include pellet density, pellet shape and size, sheath diameter and thickness, pellet/sheath clearance, coolant temperature and pressure, etc. The model has been fitted to a database of 554 power-ramp irradiations of CANDU fuel with and without Canlub. For this database the INTEGRITY model calculates 75 defects vs 75 actual defects. Similarly good agreements were noted in the different sub-groups of the data involving non-Canlub, thin-Canlub, and thick-Canlub fuel. Moreover, the shapes and the locations of the defect thresholds were consistent with all the above defects as well as with additional 14 ripple defects that were not in the above database. Two illustrative examples demonstrate how the defect thresholds are influenced by changes in the internal design of the fuel element and by extended burnup. (author). 19 refs, 7 figs

A numerical study of internal brick stresses in AGR moderator bricks

Energy Technology Data Exchange (ETDEWEB)

McNally, K., E-mail: kevin.mcnally@hsl.gsi.gov.uk [Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire SK17 9JN (United Kingdom); Fahad, M. [NGRG, School of MACE, University of Manchester, Manchester M13 9PL (United Kingdom); Tan, E.; Warren, N. [Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire SK17 9JN (United Kingdom); Hall, G.N.; Marsden, B.J. [NGRG, School of MACE, University of Manchester, Manchester M13 9PL (United Kingdom)

2016-12-01

Highlights: • A methodology for studying the uncertainty in internal brick stresses was developed. • A computationally efficient methodology based upon a surrogate model was utilised. • Uncertainty in material relationships, particularly those related to secondary creep was the dominant source of uncertainty. - Abstract: Physically-based models are often used to model changes in geometry and the associated stress fields of graphite moderator bricks within an advanced gas-cooled reactor (AGR). These models require inputs that describe the loading conditions, and coded relationships describing the behaviour of material properties. Material relationships are primarily based upon data obtained from inspection campaigns at operating reactors. However, the data from trepanning campaigns do not provide information on some of the key relationships and parameters that affect the internal stresses generated within the moderator bricks. In this work we explore how uncertain material property relationships affect the internal brick stresses in early- and late-life. We describe two computer experiments designed to study early- and late-life brick stresses and report the results from global sensitivity analysis of the models. The work makes use of an emulator, a surrogate for the FE model, in order to make the sensitivity analyses computationally feasible.

A numerical study of internal brick stresses in AGR moderator bricks

International Nuclear Information System (INIS)

McNally, K.; Fahad, M.; Tan, E.; Warren, N.; Hall, G.N.; Marsden, B.J.

2016-01-01

Highlights: • A methodology for studying the uncertainty in internal brick stresses was developed. • A computationally efficient methodology based upon a surrogate model was utilised. • Uncertainty in material relationships, particularly those related to secondary creep was the dominant source of uncertainty. - Abstract: Physically-based models are often used to model changes in geometry and the associated stress fields of graphite moderator bricks within an advanced gas-cooled reactor (AGR). These models require inputs that describe the loading conditions, and coded relationships describing the behaviour of material properties. Material relationships are primarily based upon data obtained from inspection campaigns at operating reactors. However, the data from trepanning campaigns do not provide information on some of the key relationships and parameters that affect the internal stresses generated within the moderator bricks. In this work we explore how uncertain material property relationships affect the internal brick stresses in early- and late-life. We describe two computer experiments designed to study early- and late-life brick stresses and report the results from global sensitivity analysis of the models. The work makes use of an emulator, a surrogate for the FE model, in order to make the sensitivity analyses computationally feasible.

Modelling of the Residual Stress State in a new Type of Residual Stress Specimen

DEFF Research Database (Denmark)

Jakobsen, Johnny; Andreasen, Jens Henrik

2014-01-01

forms the experimental case which is analysed. A FE model of the specimen is used for analysing the curing history and the residual stress build up. The model is validated against experimental strain data which are recorded by a Fibre Brag Grating sensor and good agreement has been achieved.......The paper presents a study on a new type residual stress specimen which is proposed as a simple way to conduct experimental validation for model predictions. A specimen comprising of a steel plate with circular hole embedded into a stack of CSM glass fibre and further infused with an epoxy resin...

Modeling of plates with multiple anisotropic layers and residual stress

DEFF Research Database (Denmark)

Engholm, Mathias; Pedersen, Thomas; Thomsen, Erik Vilain

2016-01-01

Usually the analytical approach for modeling of plates uses the single layer plate equation to obtain the deflection and does not take anisotropy and residual stress into account. Based on the stress–strain relation of each layer and balancing stress resultants and bending moments, a general...... multilayered anisotropic plate equation is developed for plates with an arbitrary number of layers. The exact deflection profile is calculated for a circular clamped plate of anisotropic materials with residual bi-axial stress.From the deflection shape the critical stress for buckling is calculated......, and an excellent agreement between the two models is seen with a relative difference of less than 2% for all calculations. The model was also used to extract the cell capacitance, the parasitic capacitance and the residual stress of a pressure sensor composed of a multilayered plate of silicon and silicon oxide...

Posttraumatic stress symptoms and the diathesis-stress model of chronic pain and disability in patients undergoing major surgery.

Science.gov (United States)

Martin, Andrea L; Halket, Eileen; Asmundson, Gordon J G; Flora, David B; Katz, Joel

2010-01-01

To (1) use structural equation modeling (SEM) to examine relationships proposed in Turk's diathesis-stress model of chronic pain and disability as well as (2) investigate what role, if any, posttraumatic stress symptoms (PTSS) play in predicting pain disability, relative to some of the other factors in the model. The study sample consisted of 208 patients scheduled for general surgery, 21 to 60 years of age (mean age=47.18 y, SD=9.72 y), who reported experiencing persistent pain for an average of 5.56 years (SD=7.90 y). At their preadmission hospital visit, patients completed the Anxiety Sensitivity Index, Pain Catastrophizing Scale, Pain Anxiety Symptoms Scale-20, Pain Disability Index, posttraumatic stress disorder Checklist, and rated the average intensity of their pain (0 to 10 numeric rating scale). SEM was used to test a model of chronic pain disability and to explore potential relationships between PTSS and factors in the diathesis-stress model. SEM results provided support for a model in which anxiety sensitivity predicted fear of pain and catastrophizing, fear of pain predicted escape/avoidance, and escape/avoidance predicted pain disability. Results also provided support for a feedback loop between disability and fear of pain. SEM analyses provided preliminary support for the inclusion of PTSS in the diathesis-stress model, with PTSS accounting for a significant proportion of the variance in pain disability. Results provide empirical support for aspects of Turk's diathesis-stress model in a sample of patients with persistent pain. Findings also offer preliminary support for the role of PTSS in fear-avoidance models of chronic pain.

Initiation model for intergranular stress corrosion cracking in BWR pipes

International Nuclear Information System (INIS)

Hishida, Mamoru; Kawakubo, Takashi; Nakagawa, Yuji; Arii, Mitsuru.

1981-01-01

Discussions were made on the keys of intergranular stress corrosion cracking of austenitic stainless steel in high-temperature water in laboratories and stress corrosion cracking incidents in operating plants. Based on these discussions, a model was set up of intergranular stress corrosion cracking initiation in BWR pipes. Regarding the model, it was presumed that the intergranular stress corrosion cracking initiates during start up periods whenever heat-affected zones in welded pipes are highly sensitized and suffer dynamic strain in transient water containing dissolved oxygen. A series of BWR start up simulation tests were made by using a flowing autoclave system with slow strain rate test equipment. Validity of the model was confirmed through the test results. (author)

Modeling of grain boundary stresses in Alloy 600

Energy Technology Data Exchange (ETDEWEB)

Kozaczek, K.J. [Oak Ridge National Lab., TN (United States); Sinharoy, A.; Ruud, C.O. [Pennsylvania State Univ., University Park, PA (United States); Mcllree, A.R. [Electric Power Research Inst., Palo Alto, CA (United States)

1995-04-01

Corrosive environments combined with high stress levels and susceptible microstructures can cause intergranular stress corrosion cracking (IGSCC) of Alloy 600 components on both primary and secondary sides of pressurized water reactors. One factor affecting the IGSCC is intergranular carbide precipitation controlled by heat treatment of Alloy 600. This study is concerned with analysis of elastic stress fields in vicinity of M{sub 7}C{sub 3} and M{sub 23}C{sub 6} carbides precipitated in the matrix and at a grain boundary triple point. The local stress concentration which can lead to IGSCC initiation was studied using a two-dimensional finite element model. The intergranular precipitates are more effective stress raisers than the intragranular precipitates. The combination of the elastic property mismatch and the precipitate shape can result in a local stress field substantially different than the macroscopic stress. The maximum local stresses in the vicinity of the intergranular precipitate were almost twice as high as the applied stress.

Modeling of CMUTs with Multiple Anisotropic Layers and Residual Stress

DEFF Research Database (Denmark)

Engholm, Mathias; Thomsen, Erik Vilain

2014-01-01

Usually the analytical approach for modeling CMUTs uses the single layer plate equation to obtain the deflection and does not take anisotropy and residual stress into account. A highly accurate model is developed for analytical characterization of CMUTs taking an arbitrary number of layers...... and residual stress into account. Based on the stress-strain relation of each layer and balancing stress resultants and bending moments, a general multilayered anisotropic plate equation is developed for plates with an arbitrary number of layers. The exact deflection profile is calculated for a circular...... clamped plate of anisotropic materials with residual bi-axial stress. From the deflection shape the critical stress for buckling is calculated and by using the Rayleigh-Ritz method the natural frequency is estimated....

Micromechanical modelling of the cyclic stress-strain behaviour of nickel polycrystals

International Nuclear Information System (INIS)

Steckmeyer, A.; Sauzay, M.; Weidner, A.; Hieckmann, E.

2012-01-01

A crystalline elasto-plasticity model is proposed to describe the cyclic behaviour of face-centred cubic crystals. It is based on many experimental observations correlating the observed dislocation structures with the orientations of corresponding crystals. The model distinguishes between two families of crystals. The first family gathers crystals for which the tension-compression loading axis is located in the centre of the standard stereo-graphic triangle. These crystals, in which bundle and/or slip band dislocation structures are usually observed, are subjected to single slip deformation. The second family gathers crystals in which labyrinths or wall dislocation structures develop. These crystals are subjected to multiple slip deformation. Crystalline plasticity parameters are adjusted using only the single crystal cyclic stress strain curves measured for one orientation of each of the two families. The relevance of the model is evaluated through finite elements calculations of the uniaxial cyclic deformation of texture-free nickel polycrystals at room temperature. The macroscopic predictions are in reasonable agreement with experimental data concerning both the cyclic stress-strain curve and the hysteresis loops provided either large grain sizes or intermediate to high plastic strains are considered. By construction, the modelling is unable to predict grain size effect observed at low plastic strain. The distributions of the mean grain plastic strains become narrower as the macroscopic plastic strain amplitude increases, which appears consistent with the large scattering in high-cycle fatigue lifetimes usually observed. On the contrary, the distributions of mean grain axial stresses get broader, in agreement with neutron and X-ray diffraction measurement values published in the literature. The influence of the material parameters is then discussed. Finally, the cumulative probability curves of the number of cycles to fatigue microcrack nucleation are deduced

Antiferromagnetic character of workplace stress

Science.gov (United States)

Watanabe, Jun-Ichiro; Akitomi, Tomoaki; Ara, Koji; Yano, Kazuo

2011-07-01

We study the nature of workplace stress from the aspect of human-human interactions. We investigated the distribution of Center for Epidemiological Studies Depression Scale scores, a measure of the degree of stress, in workplaces. We found that the degree of stress people experience when around other highly stressed people tends to be low, and vice versa. A simulation based on a model describing microlevel human-human interaction reproduced this observed phenomena and revealed that the energy state of a face-to-face communication network correlates with workplace stress macroscopically.

Ghrelin mediates stress-induced food-reward behavior in mice.

Science.gov (United States)

Chuang, Jen-Chieh; Perello, Mario; Sakata, Ichiro; Osborne-Lawrence, Sherri; Savitt, Joseph M; Lutter, Michael; Zigman, Jeffrey M

2011-07-01

The popular media and personal anecdotes are rich with examples of stress-induced eating of calorically dense "comfort foods." Such behavioral reactions likely contribute to the increased prevalence of obesity in humans experiencing chronic stress or atypical depression. However, the molecular substrates and neurocircuits controlling the complex behaviors responsible for stress-based eating remain mostly unknown, and few animal models have been described for probing the mechanisms orchestrating this response. Here, we describe a system in which food-reward behavior, assessed using a conditioned place preference (CPP) task, is monitored in mice after exposure to chronic social defeat stress (CSDS), a model of prolonged psychosocial stress, featuring aspects of major depression and posttraumatic stress disorder. Under this regime, CSDS increased both CPP for and intake of high-fat diet, and stress-induced food-reward behavior was dependent on signaling by the peptide hormone ghrelin. Also, signaling specifically in catecholaminergic neurons mediated not only ghrelin's orexigenic, antidepressant-like, and food-reward behavioral effects, but also was sufficient to mediate stress-induced food-reward behavior. Thus, this mouse model has allowed us to ascribe a role for ghrelin-engaged catecholaminergic neurons in stress-induced eating.

Stress potentiates decision biases: A stress induced deliberation-to-intuition (SIDI model

Directory of Open Access Journals (Sweden)

Rongjun Yu

2016-06-01

Full Text Available Humans often make decisions in stressful situations, for example when the stakes are high and the potential consequences severe, or when the clock is ticking and the task demand is overwhelming. In response, a whole train of biological responses to stress has evolved to allow organisms to make a fight-or-flight response. When under stress, fast and effortless heuristics may dominate over slow and demanding deliberation in making decisions under uncertainty. Here, I review evidence from behavioral studies and neuroimaging research on decision making under stress and propose that stress elicits a switch from an analytic reasoning system to intuitive processes, and predict that this switch is associated with diminished activity in the prefrontal executive control regions and exaggerated activity in subcortical reactive emotion brain areas. Previous studies have shown that when stressed, individuals tend to make more habitual responses than goal-directed choices, be less likely to adjust their initial judgment, and rely more on gut feelings in social situations. It is possible that stress influences the arbitration between the emotion responses in subcortical regions and deliberative processes in the prefrontal cortex, so that final decisions are based on unexamined innate responses. Future research may further test this ‘stress induced deliberation-to-intuition’ (SIDI model and examine its underlying neural mechanisms.

An analytical mechanical model to describe the response of NiTi rotary endodontic files in a curved root canal

Energy Technology Data Exchange (ETDEWEB)

Leroy, Agnes Marie Francoise [Department of Metallurgical and Materials Engineering, School of Engineering, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil); Department of Mechanical and Materials Engineering, Ecole des Ponts Paristech (ENPC), Champs-sur-Marne (France); Bahia, Maria Guiomar de Azevedo [Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil); Ehrlacher, Alain [Department of Mechanical and Materials Engineering, Ecole des Ponts Paristech (ENPC), Champs-sur-Marne (France); Buono, Vicente Tadeu Lopes, E-mail: vbuono@demet.ufmg.br [Department of Metallurgical and Materials Engineering, School of Engineering, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil)

2012-08-01

Aim: To build a mathematical model describing the mechanical behavior of NiTi rotary files while they are rotating in a root canal. Methodology: The file was seen as a beam undergoing large transformations. The instrument was assumed to be rotating steadily in the root canal, and the geometry of the canal was considered as a known parameter of the problem. The formulae of large transformations mechanics then allowed the calculation of the Green-Lagrange strain field in the file. The non-linear mechanical behavior of NiTi was modeled as a continuous piecewise linear function, assuming that the material did not reach plastic deformation. Criteria locating the changes of behavior of NiTi were established and the tension field in the file, and the external efforts applied on it were calculated. The unknown variable of torsion was deduced from the equilibrium equation system using a Coulomb contact law which solved the problem on a cycle of rotation. Results: In order to verify that the model described well reality, three-point bending experiments were managed on superelastic NiTi wires, whose results were compared to the theoretical ones. It appeared that the model gave a good mentoring of the empirical results in the range of bending angles that interested us. Conclusions: Knowing the geometry of the root canal, one is now able to write the equations of the strain and stress fields in the endodontic instrument, and to quantify the impact of each macroscopic parameter of the problem on its response. This should be useful to predict failure of the files under rotating bending fatigue, and to optimize the geometry of the files. - Highlights: Black-Right-Pointing-Pointer A mechanical model of the behavior of a NiTi endodontic instrument was developed. Black-Right-Pointing-Pointer The model was validated with results of three-point bending tests on NiTi wires. Black-Right-Pointing-Pointer The model is appropriate for the optimization of instruments' geometry.

An analytical mechanical model to describe the response of NiTi rotary endodontic files in a curved root canal

International Nuclear Information System (INIS)

Leroy, Agnès Marie Françoise; Bahia, Maria Guiomar de Azevedo; Ehrlacher, Alain; Buono, Vicente Tadeu Lopes

2012-01-01

Aim: To build a mathematical model describing the mechanical behavior of NiTi rotary files while they are rotating in a root canal. Methodology: The file was seen as a beam undergoing large transformations. The instrument was assumed to be rotating steadily in the root canal, and the geometry of the canal was considered as a known parameter of the problem. The formulae of large transformations mechanics then allowed the calculation of the Green–Lagrange strain field in the file. The non-linear mechanical behavior of NiTi was modeled as a continuous piecewise linear function, assuming that the material did not reach plastic deformation. Criteria locating the changes of behavior of NiTi were established and the tension field in the file, and the external efforts applied on it were calculated. The unknown variable of torsion was deduced from the equilibrium equation system using a Coulomb contact law which solved the problem on a cycle of rotation. Results: In order to verify that the model described well reality, three-point bending experiments were managed on superelastic NiTi wires, whose results were compared to the theoretical ones. It appeared that the model gave a good mentoring of the empirical results in the range of bending angles that interested us. Conclusions: Knowing the geometry of the root canal, one is now able to write the equations of the strain and stress fields in the endodontic instrument, and to quantify the impact of each macroscopic parameter of the problem on its response. This should be useful to predict failure of the files under rotating bending fatigue, and to optimize the geometry of the files. - Highlights: ► A mechanical model of the behavior of a NiTi endodontic instrument was developed. ► The model was validated with results of three-point bending tests on NiTi wires. ► The model is appropriate for the optimization of instruments' geometry.

A discrete stress-strength interference model based on universal generating function

International Nuclear Information System (INIS)

An Zongwen; Huang Hongzhong; Liu Yu

2008-01-01

Continuous stress-strength interference (SSI) model regards stress and strength as continuous random variables with known probability density function. This, to some extent, results in a limitation of its application. In this paper, stress and strength are treated as discrete random variables, and a discrete SSI model is presented by using the universal generating function (UGF) method. Finally, case studies demonstrate the validity of the discrete model in a variety of circumstances, in which stress and strength can be represented by continuous random variables, discrete random variables, or two groups of experimental data

Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging?

Science.gov (United States)

Ghatreh-Samani, Mahdi; Esmaeili, Nafiseh; Soleimani, Masoud; Asadi-Samani, Majid; Ghatreh-Samani, Keihan; Shirzad, Hedayatolah

2016-01-01

Iron overload in β-thalassemia major occurs mainly due to blood transfusion, an essential treatment for β-thalassemia major patients, which results in oxidative stress. It has been thought that oxidative stress causes elevation of immune system senescent cells. Under this condition, cells normally enhance in aging, which is referred to as premature immunosenescence. Because there is no animal model for immunosenescence, most knowledge on the immunosenescence pattern is based on induction of immunosenescence. In this review, we describe iron overload and oxidative stress in β-thalassemia major patients and how they make these patients a suitable human model for immunosenescence. We also consider oxidative stress in some kinds of chronic virus infections, which induce changes in the immune system similar to β-thalassemia major. In conclusion, a therapeutic approach used to improve the immune system in such chronic virus diseases, may change the immunosenescence state and make life conditions better for β-thalassemia major patients.

Application of a Full Reynolds Stress Model to High Lift Flows

Science.gov (United States)

Lee-Rausch, E. M.; Rumsey, C. L.; Eisfeld, B.

2016-01-01

A recently developed second-moment Reynolds stress model was applied to two challenging high-lift flows: (1) transonic flow over the ONERA M6 wing, and (2) subsonic flow over the DLR-F11 wing-body configuration from the second AIAA High Lift Prediction Workshop. In this study, the Reynolds stress model results were contrasted with those obtained from one- and two{equation turbulence models, and were found to be competitive in terms of the prediction of shock location and separation. For an ONERA M6 case, results from multiple codes, grids, and models were compared, with the Reynolds stress model tending to yield a slightly smaller shock-induced separation bubble near the wing tip than the simpler models, but all models were fairly close to the limited experimental surface pressure data. For a series of high-lift DLR{F11 cases, the range of results was more limited, but there was indication that the Reynolds stress model yielded less-separated results than the one-equation model near maximum lift. These less-separated results were similar to results from the one-equation model with a quadratic constitutive relation. Additional computations need to be performed before a more definitive assessment of the Reynolds stress model can be made.

Modelling effects of tyre inflation pressure on the stress distribution near the soil-tyre interface

DEFF Research Database (Denmark)

Schjønning, Per; Lamandé, Mathieu; Tøgersen, Frede A

2008-01-01

stress in the contact area for two radial-ply agricultural trailer tyres (650/65R30.5 and 800/50R34) loaded with 60 kN. The study took place on a sandy soil at a water content slightly less than field capacity. We tested the effect of three different inflation pressures (50, 100 and 240 k......Pa) in a randomised block design with three replicates. The vertical stress was measured with load cells located in 0.1 m soil depth. The vertical stress data were used also for identifying the soil area in contact with the tyre, i.e. the tyre footprint. A model (named FRIDA) is proposed that describes the tyre...... footprint by a super ellipse and the stress distribution by a combined exponential (perpendicular to the driving direction) and power-law (along the driving direction) function. The contact area doubled when the inflation pressure was reduced from 240 to 50 kPa. For both tyres, the measured peak stress...

An extended car-following model to describe connected traffic dynamics under cyberattacks

Science.gov (United States)

Wang, Pengcheng; Yu, Guizhen; Wu, Xinkai; Qin, Hongmao; Wang, Yunpeng

2018-04-01

In this paper, the impacts of the potential cyberattacks on vehicles are modeled through an extended car-following model. To better understand the mechanism of traffic disturbance under cyberattacks, the linear and nonlinear stability analysis are conducted respectively. Particularly, linear stability analysis is performed to obtain different neutral stability conditions with various parameters; and nonlinear stability analysis is carried out by using reductive perturbation method to derive the soliton solution of the modified Korteweg de Vries equation (mKdV) near the critical point, which is used to draw coexisting stability lines. Furthermore, by applying linear and nonlinear stability analysis, traffic flow state can be divided into three states, i.e., stable, metastable and unstable states which are useful to describe shockwave dynamics and driving behaviors under cyberattacks. The theoretical results show that the proposed car-following model is capable of successfully describing the car-following behavior of connected vehicles with cyberattacks. Finally, numerical simulation using real values has confirmed the validity of theoretical analysis. The results further demonstrate our model can be used to help avoid collisions and relieve traffic congestion with cybersecurity threats.

Caenorhabditis elegans: A Useful Model for Studying Metabolic Disorders in Which Oxidative Stress Is a Contributing Factor

Directory of Open Access Journals (Sweden)

Elizabeth Moreno-Arriola

2014-01-01

Full Text Available Caenorhabditis elegans is a powerful model organism that is invaluable for experimental research because it can be used to recapitulate most human diseases at either the metabolic or genomic level in vivo. This organism contains many key components related to metabolic and oxidative stress networks that could conceivably allow us to increase and integrate information to understand the causes and mechanisms of complex diseases. Oxidative stress is an etiological factor that influences numerous human diseases, including diabetes. C. elegans displays remarkably similar molecular bases and cellular pathways to those of mammals. Defects in the insulin/insulin-like growth factor-1 signaling pathway or increased ROS levels induce the conserved phase II detoxification response via the SKN-1 pathway to fight against oxidative stress. However, it is noteworthy that, aside from the detrimental effects of ROS, they have been proposed as second messengers that trigger the mitohormetic response to attenuate the adverse effects of oxidative stress. Herein, we briefly describe the importance of C. elegans as an experimental model system for studying metabolic disorders related to oxidative stress and the molecular mechanisms that underlie their pathophysiology.

Mathematical model of polyethylene pipe bending stress state

Science.gov (United States)

Serebrennikov, Anatoly; Serebrennikov, Daniil

2018-03-01

Introduction of new machines and new technologies of polyethylene pipeline installation is usually based on the polyethylene pipe flexibility. It is necessary that existing bending stresses do not lead to an irreversible polyethylene pipe deformation and to violation of its strength characteristics. Derivation of the mathematical model which allows calculating analytically the bending stress level of polyethylene pipes with consideration of nonlinear characteristics is presented below. All analytical calculations made with the mathematical model are experimentally proved and confirmed.

Modeling the flow in a 90 deg. rectangular duct using one Reynolds-stress and two eddy-viscosity models

International Nuclear Information System (INIS)

Yakinthos, K.; Vlahostergios, Z.; Goulas, A.

2008-01-01

A new effort to model the flow in a 90 deg. rectangular duct by adopting three low-Reynolds-number turbulence models, two eddy-viscosity models (a linear and a non-linear) and a Reynolds-stress model, is presented. The complex flow development is a challenge for the application of turbulence models in order to assess their capability to capture the secondary flow and the developing vortices due to curvature and strong pressure gradient effects. The numerical results show that both the non-linear eddy-viscosity and the Reynolds-stress models can provide good results, especially for the velocity distributions. The superiority of the Reynolds-stress model is shown primarily in the Reynolds-stress distributions, which have the best quality among the predictions from the other models. On the other hand, the main advantage of the non-linear model is its simplicity and the smaller needed CPU cost, compared to the Reynolds-stress model. Additionally, in some stations of the flow development, the non-linear model provides good velocity distributions. The linear model gives lower quality predictions for the Reynolds-stress distributions, although it is capable in providing quite satisfactory results for the velocity distributions

An accelerated life test model for harmonic drives under a segmental stress history and its parameter optimization

Directory of Open Access Journals (Sweden)

Zhang Chao

2015-12-01

Full Text Available Harmonic drives have various distinctive advantages and are widely used in space drive mechanisms. Accelerated life test (ALT is commonly conducted to shorten test time and reduce associated costs. An appropriate ALT model is needed to predict the lifetime of harmonic drives with ALT data. However, harmonic drives which are used in space usually work under a segmental stress history, and traditional ALT models can hardly be used in this situation. This paper proposes a dedicated ALT model for harmonic drives applied in space systems. A comprehensive ALT model is established and genetic algorithm (GA is adopted to obtain optimal parameters in the model using the Manson fatigue damage rule to describe the fatigue failure process and a cumulative damage method to calculate and accumulate the damage caused by each segment in the stress history. An ALT of harmonic drives was carried out and experimental results show that this model is acceptable and effective.

A kinematic hardening constitutive model for the uniaxial cyclic stress-strain response of magnesium sheet alloys at room temperature

Science.gov (United States)

He, Zhitao; Chen, Wufan; Wang, Fenghua; Feng, Miaolin

2017-11-01

A kinematic hardening constitutive model is presented, in which a modified form of von Mises yield function is adopted, and the initial asymmetric tension and compression yield stresses of magnesium (Mg) alloys at room temperature (RT) are considered. The hardening behavior was classified into slip, twinning, and untwinning deformation modes, and these were described by two forms of back stress to capture the mechanical response of Mg sheet alloys under cyclic loading tests at RT. Experimental values were obtained for AZ31B-O and AZ31B sheet alloys under both tension-compression-tension (T-C-T) and compression-tension (C-T) loadings to calibrate the parameters of back stresses in the proposed model. The predicted parameters of back stresses in the twinning and untwinning modes were expressed as a cubic polynomial. The predicted curves based on these parameters showed good agreement with the tests.

Modeling and Measurement of Stress and Strain Evolution in Cu Interconnects

International Nuclear Information System (INIS)

Besser, Paul R.; Zhai, Charlie Jun

2004-01-01

The damascene fabrication method and the introduction of low-K dielectrics present a host of reliability challenges to Cu interconnects and fundamentally change the mechanical stress state of Cu lines used as interconnects for integrated circuits. In order to capture the effect of individual process steps on the stress evolution in the BEoL (Back End of Line), a process-oriented finite element modeling (FEM) approach was developed. In this model, the complete stress history at any step of BEoL can be simulated as a dual damascene Cu structure is fabricated. The model was calibrated with both wafer-curvature blanket film measurements and X-Ray diffraction (XRD) measurement of metal line stress. The Cu line stress evolution was simulated during the process of multi-step processing for dual damascene Cu/TEOS and Cu/low-k structures. The in-plane stress of Cu lines is nearly independent of subsequent processes, while the out-of-plane stress increases considerably with the subsequent process steps. The modeling results will be compared with recent XRD measurements and extended generically to illustrate the relative influence of the dielectric (ILD) modulus (E) and coefficient of thermal expansion (CTE) on strain/stress in the Cu lines. It will be shown that the stress magnitude and state (hydrostatic, deviatoric) depend on ILD properties. The stress along the line length (longitudinal) is substrate-dominated, while the transverse and normal stresses vary with both CTE and modulus of the dielectric. The hydrostatic stress is primarily determined by ILD modulus and is nearly independent of the ILD CTE, while the Von Mises stress depends on both CTE and E of the ILD. The stress of the Cu line tends to be more deviatoric with spin-on low K ILDs, and more hydrostatic with oxide encapsulation

A Reynolds stress model for near-wall turbulence

Science.gov (United States)

Durbin, P. A.

1993-01-01

The paper formulates a tensorially consistent near-wall second-order closure model. Redistributive terms in the Reynolds stress equations are modeled by an elliptic relaxation equation in order to represent strongly nonhomogeneous effects produced by the presence of walls; this replaces the quasi-homogeneous algebraic models that are usually employed, and avoids the need for ad hoc damping functions. The model is solved for channel flow and boundary layers with zero and adverse pressure gradients. Good predictions of Reynolds stress components, mean flow, skin friction, and displacement thickness are obtained in various comparisons to experimental and direct numerical simulation data. The model is also applied to a boundary layer flowing along a wall with a 90-deg, constant-radius, convex bend.

Using multiple biomarkers and determinants to obtain a better measurement of oxidative stress: a latent variable structural equation model approach.

Science.gov (United States)

Eldridge, Ronald C; Flanders, W Dana; Bostick, Roberd M; Fedirko, Veronika; Gross, Myron; Thyagarajan, Bharat; Goodman, Michael

2017-09-01

Since oxidative stress involves a variety of cellular changes, no single biomarker can serve as a complete measure of this complex biological process. The analytic technique of structural equation modeling (SEM) provides a possible solution to this problem by modelling a latent (unobserved) variable constructed from the covariance of multiple biomarkers. Using three pooled datasets, we modelled a latent oxidative stress variable from five biomarkers related to oxidative stress: F 2 -isoprostanes (FIP), fluorescent oxidation products, mitochondrial DNA copy number, γ-tocopherol (Gtoc) and C-reactive protein (CRP, an inflammation marker closely linked to oxidative stress). We validated the latent variable by assessing its relation to pro- and anti-oxidant exposures. FIP, Gtoc and CRP characterized the latent oxidative stress variable. Obesity, smoking, aspirin use and β-carotene were statistically significantly associated with oxidative stress in the theorized directions; the same exposures were weakly and inconsistently associated with the individual biomarkers. Our results suggest that using SEM with latent variables decreases the biomarker-specific variability, and may produce a better measure of oxidative stress than do single variables. This methodology can be applied to similar areas of research in which a single biomarker is not sufficient to fully describe a complex biological phenomenon.

The calm mouse: an animal model of stress reduction.

Science.gov (United States)

Gurfein, Blake T; Stamm, Andrew W; Bacchetti, Peter; Dallman, Mary F; Nadkarni, Nachiket A; Milush, Jeffrey M; Touma, Chadi; Palme, Rupert; Di Borgo, Charles Pozzo; Fromentin, Gilles; Lown-Hecht, Rachel; Konsman, Jan Pieter; Acree, Michael; Premenko-Lanier, Mary; Darcel, Nicolas; Hecht, Frederick M; Nixon, Douglas F

2012-05-09

Chronic stress is associated with negative health outcomes and is linked with neuroendocrine changes, deleterious effects on innate and adaptive immunity, and central nervous system neuropathology. Although stress management is commonly advocated clinically, there is insufficient mechanistic understanding of how decreasing stress affects disease pathogenesis. Therefore, we have developed a "calm mouse model" with caging enhancements designed to reduce murine stress. Male BALB/c mice were divided into four groups: control (Cntl), standard caging; calm (Calm), large caging to reduce animal density, a cardboard nest box for shelter, paper nesting material to promote innate nesting behavior, and a polycarbonate tube to mimic tunneling; control exercise (Cntl Ex), standard caging with a running wheel, known to reduce stress; and calm exercise (Calm Ex), calm caging with a running wheel. Calm, Cntl Ex and Calm Ex animals exhibited significantly less corticosterone production than Cntl animals. We also observed changes in spleen mass, and in vitro splenocyte studies demonstrated that Calm Ex animals had innate and adaptive immune responses that were more sensitive to acute handling stress than those in Cntl. Calm animals gained greater body mass than Cntl, although they had similar food intake, and we also observed changes in body composition, using magnetic resonance imaging. Together, our results suggest that the Calm mouse model represents a promising approach to studying the biological effects of stress reduction in the context of health and in conjunction with existing disease models.

Approaches to modeling the development of physiological stress responsivity.

Science.gov (United States)

Hinnant, J Benjamin; Philbrook, Lauren E; Erath, Stephen A; El-Sheikh, Mona

2018-05-01

Influential biopsychosocial theories have proposed that some developmental periods in the lifespan are potential pivot points or opportunities for recalibration of stress response systems. To date, however, there have been few longitudinal studies of physiological stress responsivity and no studies comparing change in physiological stress responsivity across developmental periods. Our goals were to (a) address conceptual and methodological issues in studying the development of physiological stress responsivity within and between individuals, and (b) provide an exemplar for evaluating development of responsivity to stress in the parasympathetic nervous system, comparing respiratory sinus arrhythmia (RSA) responsivity from middle to late childhood with middle to late adolescence. We propose the use of latent growth modeling of stress responsivity that includes time-varying covariates to account for conceptual and methodological issues in the measurement of physiological stress responsivity. Such models allow researchers to address key aspects of developmental sensitivity including within-individual variability, mean level change over time, and between-individual variability over time. In an empirical example, we found significant between-individual variability over time in RSA responsivity to stress during middle to late childhood but not during middle to late adolescence, suggesting that childhood may be a period of greater developmental sensitivity at the between-individual level. © 2017 Society for Psychophysiological Research.

The organization of irrational beliefs in posttraumatic stress symptomology: testing the predictions of REBT theory using structural equation modelling.

Science.gov (United States)

Hyland, Philip; Shevlin, Mark; Adamson, Gary; Boduszek, Daniel

2014-01-01

This study directly tests a central prediction of rational emotive behaviour therapy (REBT) that has received little empirical attention regarding the core and intermediate beliefs in the development of posttraumatic stress symptoms. A theoretically consistent REBT model of posttraumatic stress disorder (PTSD) was examined using structural equation modelling techniques among a sample of 313 trauma-exposed military and law enforcement personnel. The REBT model of PTSD provided a good fit of the data, χ(2) = 599.173, df = 356, p depreciation beliefs. Results were consistent with the predictions of REBT theory and provides strong empirical support that the cognitive variables described by REBT theory are critical cognitive constructs in the prediction of PTSD symptomology. © 2013 Wiley Periodicals, Inc.

Using the MWC model to describe heterotropic interactions in hemoglobin

Science.gov (United States)

Rapp, Olga

2017-01-01

Hemoglobin is a classical model allosteric protein. Research on hemoglobin parallels the development of key cooperativity and allostery concepts, such as the ‘all-or-none’ Hill formalism, the stepwise Adair binding formulation and the concerted Monod-Wymann-Changuex (MWC) allosteric model. While it is clear that the MWC model adequately describes the cooperative binding of oxygen to hemoglobin, rationalizing the effects of H+, CO2 or organophosphate ligands on hemoglobin-oxygen saturation using the same model remains controversial. According to the MWC model, allosteric ligands exert their effect on protein function by modulating the quaternary conformational transition of the protein. However, data fitting analysis of hemoglobin oxygen saturation curves in the presence or absence of inhibitory ligands persistently revealed effects on both relative oxygen affinity (c) and conformational changes (L), elementary MWC parameters. The recent realization that data fitting analysis using the traditional MWC model equation may not provide reliable estimates for L and c thus calls for a re-examination of previous data using alternative fitting strategies. In the current manuscript, we present two simple strategies for obtaining reliable estimates for MWC mechanistic parameters of hemoglobin steady-state saturation curves in cases of both evolutionary and physiological variations. Our results suggest that the simple MWC model provides a reasonable description that can also account for heterotropic interactions in hemoglobin. The results, moreover, offer a general roadmap for successful data fitting analysis using the MWC model. PMID:28793329

Double porosity model to describe both permeability change and dissolution processes

International Nuclear Information System (INIS)

Niibori, Yuichi; Usui, Hideo; Chida, Taiji

2015-01-01

Cement is a practical material for constructing the geological disposal system of radioactive wastes. The dynamic behavior of both permeability change and dissolution process caused by a high pH groundwater was explained using a double porosity model assuming that each packed particle consists of the sphere-shaped aggregation of smaller particles. This model assumes two kinds of porosities between the particle clusters and between the particles, where the former porosity change mainly controls the permeability change of the bed, and the latter porosity change controls the diffusion of OH"- ions inducing the dissolution of silica. The fundamental equations consist of a diffusion equation of spherical coordinates of OH"- ions including the first-order reaction term and some equations describing the size changes of both the particles and the particle clusters with time. The change of over-all permeability of the packed bed is evaluated by Kozeny-Carman equation and the calculated radii of particle clusters. The calculated result well describes the experimental result of both permeability change and dissolution processes. (author)

Focal adhesions, stress fibers and mechanical tension

Energy Technology Data Exchange (ETDEWEB)

Burridge, Keith, E-mail: Keith_Burridge@med.unc.edu [Department of Cell Biology and Physiology, and Lineberger Comprehensive Cancer Center, 12-016 Lineberger, CB#7295, University of North Carolina, Chapel Hill, NC (United States); Guilluy, Christophe, E-mail: christophe.guilluy@univ-nantes.fr [Inserm UMR-S1087, CNRS UMR-C6291, L' institut du Thorax, and Université de Nantes, Nantes (France)

2016-04-10

Stress fibers and focal adhesions are complex protein arrays that produce, transmit and sense mechanical tension. Evidence accumulated over many years led to the conclusion that mechanical tension generated within stress fibers contributes to the assembly of both stress fibers themselves and their associated focal adhesions. However, several lines of evidence have recently been presented against this model. Here we discuss the evidence for and against the role of mechanical tension in driving the assembly of these structures. We also consider how their assembly is influenced by the rigidity of the substratum to which cells are adhering. Finally, we discuss the recently identified connections between stress fibers and the nucleus, and the roles that these may play, both in cell migration and regulating nuclear function. - Highlights: • The different types of stress fiber and focal adhesion are described. • We discuss the controversy about tension and assembly of these structures. • We describe the different models used to investigate assembly of these structures. • The influence of substratum rigidity is discussed. • Stress fiber connections to the nucleus are reviewed.

Electromagnetic modeling of stress corrosion cracks in Inconel welds

International Nuclear Information System (INIS)

Huang, Haoyu; Miya, Kenzo; Yusa, Noritaka; Hashizume, Hidetoshi; Sera, Takehiko; Hirano, Shinro

2011-01-01

This study evaluates suitable numerical modeling of stress corrosion cracks appearing in Inconel welds from the viewpoint of electromagnetic nondestructive evaluations. The stress corrosion cracks analyzed in this study are five artificial ones introduced into welded flat plate, and three natural ones found in a pressurized nuclear power plant. Numerical simulations model a crack as a planar region having a uniform conductivity inside and a constant width, and evaluate the width and conductivity that reproduce the maximum eddy current signals obtained by experiments. The results obtained validate the existence of the minimum value of the equivalent resistance, which is defined by the width divided by conductivity. In contrast, the values of the width and conductivity themselves vary across a wide range. The results also lead to a discussion about (1) the effect of probe utilized on the numerical model, (2) the difference between artificial and natural stress corrosion cracks, and (3) the difference between stress corrosion cracks in base metals and those in Inconel welds in their models. Electromagnetic characteristics of four different Inconel weld alloys are additionally evaluated using a resistance tester and a vibrating sample magnetometer to support the validity of the numerical modeling and the generality of results obtained. (author)

A STRUCTURAL MODEL DESCRIBE CHINESE TRADESMEN ATTITUDES TOWARDS GREEK STUDENTS CONSUMPTION BEHAVIOR

Directory of Open Access Journals (Sweden)

Sofia D. ANASTASIADOU

2012-12-01

Full Text Available This study tests evaluates 43 Chinese tradesmen opinios describe the main factors that influnce Greek consumers’ behavior. A structural model was constructed to represent the relationship between consumer components. The model was tested for its Convergent and Discriminant Validity. Moreover it was tested for its reliability and construct reliability. The findings from this study may be used by Chinese tradesmen to develop their marketing campains and customers.

Local yield stress statistics in model amorphous solids

Science.gov (United States)

Barbot, Armand; Lerbinger, Matthias; Hernandez-Garcia, Anier; García-García, Reinaldo; Falk, Michael L.; Vandembroucq, Damien; Patinet, Sylvain

2018-03-01

We develop and extend a method presented by Patinet, Vandembroucq, and Falk [Phys. Rev. Lett. 117, 045501 (2016), 10.1103/PhysRevLett.117.045501] to compute the local yield stresses at the atomic scale in model two-dimensional Lennard-Jones glasses produced via differing quench protocols. This technique allows us to sample the plastic rearrangements in a nonperturbative manner for different loading directions on a well-controlled length scale. Plastic activity upon shearing correlates strongly with the locations of low yield stresses in the quenched states. This correlation is higher in more structurally relaxed systems. The distribution of local yield stresses is also shown to strongly depend on the quench protocol: the more relaxed the glass, the higher the local plastic thresholds. Analysis of the magnitude of local plastic relaxations reveals that stress drops follow exponential distributions, justifying the hypothesis of an average characteristic amplitude often conjectured in mesoscopic or continuum models. The amplitude of the local plastic rearrangements increases on average with the yield stress, regardless of the system preparation. The local yield stress varies with the shear orientation tested and strongly correlates with the plastic rearrangement locations when the system is sheared correspondingly. It is thus argued that plastic rearrangements are the consequence of shear transformation zones encoded in the glass structure that possess weak slip planes along different orientations. Finally, we justify the length scale employed in this work and extract the yield threshold statistics as a function of the size of the probing zones. This method makes it possible to derive physically grounded models of plasticity for amorphous materials by directly revealing the relevant details of the shear transformation zones that mediate this process.

Effects of induced stress on seismic forward modelling and inversion

Science.gov (United States)

Tromp, Jeroen; Trampert, Jeannot

2018-05-01

We demonstrate how effects of induced stress may be incorporated in seismic modelling and inversion. Our approach is motivated by the accommodation of pre-stress in global seismology. Induced stress modifies both the equation of motion and the constitutive relationship. The theory predicts that induced pressure linearly affects the unstressed isotropic moduli with a slope determined by their adiabatic pressure derivatives. The induced deviatoric stress produces anisotropic compressional and shear wave speeds; the latter result in shear wave splitting. For forward modelling purposes, we determine the weak form of the equation of motion under induced stress. In the context of the inverse problem, we determine induced stress sensitivity kernels, which may be used for adjoint tomography. The theory is illustrated by considering 2-D propagation of SH waves and related Fréchet derivatives based on a spectral-element method.

Materials model for describing the austenite-martensite phase transformation considering transformation-induced plasticity; Ein Materialmodell zur Beschreibung der Austenit-Martensit Phasentransformation unter Beruecksichtigung der transformationsinduzierten Plastizitaet

Energy Technology Data Exchange (ETDEWEB)

Oberste-Brandenburg, C.

1999-06-01

In this thesis, a model to describe the austenite martensite transformation was developed. The transformation induced plasticity (TRIP) was taken into consideration. The model can be used to design complex structures. A local examination of the energy and entropy balance at the phase boundary serves as the starting point for the identification of the thermodynamical driving force and the thermodynamic flow. For both, a tensorial description is necessary for a general nonhydrostatically stressed solid. In the second part, a material law for the description of TRIP-Steels was developed based on the values derived in the first part. The different mechanical behavior of the phases, especially the differing yield stresses, was taken into account. The model developed was implemented into the finite element program MARC. Simulations of the material and the structural behavior were performed. The experimentally observed strong dependence of the transformation kinetics on the yield stress of the austenite and the dependence of the orientation of the martensite inclusion on the stress state could be verified. (orig.) [German] Im Rahmen dieser Arbeit wurde ein Materialmodell zur Beschreibung der Austenit-Martensit Phasenumwandlung unter Beruecksichtigung der transformationsinduzierten Plastizitaet (TRIP) entwickelt. Das Modell ist zur Berechnung ausgedehnter Strukturen einsetzbar. Eine lokale Betrachtung der Energie- und Entropiebilanz an der Phasengrenze bildet den Ausgangspunkt zur Identifikation der thermodynamischen Kraft und des thermodynamischen Flusses bei Beschreibung der Transformationskinetik. Fuer beide Groessen muss fuer den allgemein nichthydrostatischen Spannungszustand eine tensorielle Beschreibung verwendet werden. Im zweiten Teil der Arbeit bilden diese Groessen die Basis zur Entwicklung eines Stoffgesetzes zur Beschreibung des TRIP-Phaenomens. Es wird das unterschiedliche mechanische Verhalten der Phasen, insbesondere die stark unterschiedlichen

Numerical model describing the heat transfer between combustion products and ventilation-system duct walls

International Nuclear Information System (INIS)

Bolstad, J.W.; Foster, R.D.; Gregory, W.S.

1983-01-01

A package of physical models simulating the heat transfer processes occurring between combustion gases and ducts in ventilation systems is described. The purpose of the numerical model is to predict how the combustion gas in a system heats up or cools down as it flows through the ducts in a ventilation system under fire conditions. The model treats a duct with (forced convection) combustion gases flowing on the inside and stagnant ambient air on the outside. The model is composed of five submodels of heat transfer processes along with a numerical solution procedure to evaluate them. Each of these quantities is evaluated independently using standard correlations based on experimental data. The details of the physical assumptions, simplifications, and ranges of applicability of the correlations are described. A typical application of this model to a full-scale fire test is discussed, and model predictions are compared with selected experimental data

Micromagnetic modeling of the effects of stress on magnetic properties

International Nuclear Information System (INIS)

Zhu, B.; Lo, C. C. H.; Lee, S. J.; Jiles, D. C.

2001-01-01

A micromagnetic model has been developed for investigating the effect of stress on the magnetic properties of thin films. This effect has been implemented by including the magnetoelastic energy term into the Landau - Lifshitz - Gilbert equation. Magnetization curves of a nickel film were calculated under both tensile and compressive stresses of various magnitudes applied along the field direction. The modeling results show that coercivity increased with increasing compressive stress while remanence decreased with increasing tensile stress. The results are in agreement with the experimental data in the literature and can be interpreted in terms of the effects of the applied stress on the irreversible rotation of magnetic moments during magnetization reversal under an applied field. [copyright] 2001 American Institute of Physics

Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model

Energy Technology Data Exchange (ETDEWEB)

Chang, Yoke-Chen; Wang, James D. [Rutgers University, Pharmacology and Toxicology, 170 Frelinghuysen Rd, Piscataway, NJ 08854 (United States); Svoboda, Kathy K. [Texas A and M University, Baylor College of Dentistry, Center for Craniofacial Research 3302 Gaston Ave, Dallas, Texas 75246 (United States); Casillas, Robert P. [MRIGlobal, 425 Volker Boulevard, Kansas City, MO 64110 (United States); Laskin, Jeffrey D. [UMDNJ-Robert Wood Johnson Medical School, Environmental and Occupational Medicine, 170 Frelinghuysen Rd, Piscataway, NJ 08854 (United States); Gordon, Marion K. [Rutgers University, Pharmacology and Toxicology, 170 Frelinghuysen Rd, Piscataway, NJ 08854 (United States); Gerecke, Donald R., E-mail: gerecke@eohsi.rutgers.edu [Rutgers University, Pharmacology and Toxicology, 170 Frelinghuysen Rd, Piscataway, NJ 08854 (United States)

2013-04-15

The endoplasmic reticulum (ER) stress response is a cell survival pathway upregulated when cells are under severe stress. Severely damaged mouse ear skin exposed to the vesicant, sulfur mustard (bis-2-chloroethyl sulfide, SM), resulted in increased expression of ER chaperone proteins that accompany misfolded and incorrectly made proteins targeted for degradation. Time course studies with SM using the mouse ear vesicant model (MEVM) showed progressive histopathologic changes including edema, separation of the epidermis from the dermis, persistent inflammation, upregulation of laminin γ2 (one of the chains of laminin-332, a heterotrimeric skin glycoprotein required for wound repair), and delayed wound healing from 24 h to 168 h post exposure. This was associated with time related increased expression of the cell survival ER stress marker, GRP78/BiP, and the ER stress apoptosis marker, GADD153/CHOP, suggesting simultaneous activation of both cell survival and non-mitochondrial apoptosis pathways. Dual immunofluorescence labeling of a keratinocyte migration promoting protein, laminin γ2 and GRP78/BIP, showed colocalization of the two molecules 72 h post exposure indicating that the laminin γ2 was misfolded after SM exposure and trapped within the ER. Taken together, these data show that ER stress is induced in mouse skin within 24 h of vesicant exposure in a defensive response to promote cell survival; however, it appears that this response is rapidly overwhelmed by the apoptotic pathway as a consequence of severe SM-induced injury. - Highlights: ► We demonstrated ER stress response in the mouse ear vesicant model. ► We described the asymmetrical nature of wound repair in the MEVM. ► We identified the distribution of various ER stress markers in the MEVM.

The Role of Difficulty in Identifying and Describing Feelings in Non-Suicidal Self-Injury Behavior (NSSI): Associations With Perceived Attachment Quality, Stressful Life Events, and Suicidal Ideation.

Science.gov (United States)

Cerutti, Rita; Zuffianò, Antonio; Spensieri, Valentina

2018-01-01

Objective: Core alexithymic features, such as the difficulty in identifying and describing feelings, are associated with poor attachment styles and emotional trauma, which influence the capacity to regulate affect. Additionally, emotional regulation has been found to be the most commonly identified function associated with non-suicidal self-injury behavior (NSSI) in adolescents as they attempt to modulate strong emotions. However, few studies have examined the link between difficulty in identifying and describing feelings (core components of alexithymia), NSSI behaviors, quality of attachment, life stressors and suicidal ideation in healthy early adolescents. Consequently, this study aims to investigate these constructs and the relationship among them in a large non-clinical sample of adolescents. Methods: Seven hundred and nine middle school students (50.4% males), aged 10-15 years ( M = 12.6; SD = 1.06) were involved in this study. In order to investigate the variables considered in the study, the following measures were administered: the Deliberate Self-Harm Inventory exploring non-suicidal self-injurious behaviors; the Alexithymia Questionnaire for Children examining difficulty in identifying and describing feelings; the Inventory of Parent and Peer Attachment assessing the quality of parental and peer attachment; the Life Stressor Checklist-Revised outlining stressful/traumatic events and the Children's Depression Inventory evaluating suicidal ideation. Results: We found significantly positive relationships among difficulty in identifying and describing feelings, NSSI behaviors, stressful events, and suicidal ideation. Data indicated a significant negative association of difficulty in identifying and describing feelings with quality of attachment to parents and peers. Further findings highlighted that difficulty in identifying and describing feelings significantly mediated the effect of quality of attachment (parent and peer) on NSSI and suicidal ideation

A theoretical model to describe progressions and regressions for exercise rehabilitation.

Science.gov (United States)

Blanchard, Sam; Glasgow, Phil

2014-08-01

This article aims to describe a new theoretical model to simplify and aid visualisation of the clinical reasoning process involved in progressing a single exercise. Exercise prescription is a core skill for physiotherapists but is an area that is lacking in theoretical models to assist clinicians when designing exercise programs to aid rehabilitation from injury. Historical models of periodization and motor learning theories lack any visual aids to assist clinicians. The concept of the proposed model is that new stimuli can be added or exchanged with other stimuli, either intrinsic or extrinsic to the participant, in order to gradually progress an exercise whilst remaining safe and effective. The proposed model maintains the core skills of physiotherapists by assisting clinical reasoning skills, exercise prescription and goal setting. It is not limited to any one pathology or rehabilitation setting and can adapted by any level of skilled clinician. Copyright © 2014 Elsevier Ltd. All rights reserved.

Revised Reynolds Stress and Triple Product Models

Science.gov (United States)

Olsen, Michael E.; Lillard, Randolph P.

2017-01-01

Revised versions of Lag methodology Reynolds-stress and triple product models are applied to accepted test cases to assess the improvement, or lack thereof, in the prediction capability of the models. The Bachalo-Johnson bump flow is shown as an example for this abstract submission.

INCAS: an analytical model to describe displacement cascades

Energy Technology Data Exchange (ETDEWEB)

Jumel, Stephanie E-mail: stephanie.jumel@edf.fr; Claude Van-Duysen, Jean E-mail: jean-claude.van-duysen@edf.fr

2004-07-01

REVE (REactor for Virtual Experiments) is an international project aimed at developing tools to simulate neutron irradiation effects in Light Water Reactor materials (Fe, Ni or Zr-based alloys). One of the important steps of the project is to characterise the displacement cascades induced by neutrons. Accordingly, the Department of Material Studies of Electricite de France developed an analytical model based on the binary collision approximation. This model, called INCAS (INtegration of CAScades), was devised to be applied on pure elements; however, it can also be used on diluted alloys (reactor pressure vessel steels, etc.) or alloys composed of atoms with close atomic numbers (stainless steels, etc.). INCAS describes displacement cascades by taking into account the nuclear collisions and electronic interactions undergone by the moving atoms. In particular, it enables to determine the mean number of sub-cascades induced by a PKA (depending on its energy) as well as the mean energy dissipated in each of them. The experimental validation of INCAS requires a large effort and could not be carried out in the framework of the study. However, it was verified that INCAS results are in conformity with those obtained from other approaches. As a first application, INCAS was applied to determine the sub-cascade spectrum induced in iron by the neutron spectrum corresponding to the central channel of the High Flux Irradiation Reactor of Oak Ridge National Laboratory.

INCAS: an analytical model to describe displacement cascades

Science.gov (United States)

Jumel, Stéphanie; Claude Van-Duysen, Jean

2004-07-01

REVE (REactor for Virtual Experiments) is an international project aimed at developing tools to simulate neutron irradiation effects in Light Water Reactor materials (Fe, Ni or Zr-based alloys). One of the important steps of the project is to characterise the displacement cascades induced by neutrons. Accordingly, the Department of Material Studies of Electricité de France developed an analytical model based on the binary collision approximation. This model, called INCAS (INtegration of CAScades), was devised to be applied on pure elements; however, it can also be used on diluted alloys (reactor pressure vessel steels, etc.) or alloys composed of atoms with close atomic numbers (stainless steels, etc.). INCAS describes displacement cascades by taking into account the nuclear collisions and electronic interactions undergone by the moving atoms. In particular, it enables to determine the mean number of sub-cascades induced by a PKA (depending on its energy) as well as the mean energy dissipated in each of them. The experimental validation of INCAS requires a large effort and could not be carried out in the framework of the study. However, it was verified that INCAS results are in conformity with those obtained from other approaches. As a first application, INCAS was applied to determine the sub-cascade spectrum induced in iron by the neutron spectrum corresponding to the central channel of the High Flux Irradiation Reactor of Oak Ridge National Laboratory.

INCAS: an analytical model to describe displacement cascades

International Nuclear Information System (INIS)

Jumel, Stephanie; Claude Van-Duysen, Jean

2004-01-01

REVE (REactor for Virtual Experiments) is an international project aimed at developing tools to simulate neutron irradiation effects in Light Water Reactor materials (Fe, Ni or Zr-based alloys). One of the important steps of the project is to characterise the displacement cascades induced by neutrons. Accordingly, the Department of Material Studies of Electricite de France developed an analytical model based on the binary collision approximation. This model, called INCAS (INtegration of CAScades), was devised to be applied on pure elements; however, it can also be used on diluted alloys (reactor pressure vessel steels, etc.) or alloys composed of atoms with close atomic numbers (stainless steels, etc.). INCAS describes displacement cascades by taking into account the nuclear collisions and electronic interactions undergone by the moving atoms. In particular, it enables to determine the mean number of sub-cascades induced by a PKA (depending on its energy) as well as the mean energy dissipated in each of them. The experimental validation of INCAS requires a large effort and could not be carried out in the framework of the study. However, it was verified that INCAS results are in conformity with those obtained from other approaches. As a first application, INCAS was applied to determine the sub-cascade spectrum induced in iron by the neutron spectrum corresponding to the central channel of the High Flux Irradiation Reactor of Oak Ridge National Laboratory

New Model to describe the interaction of slow neutrons with solid deuterium

International Nuclear Information System (INIS)

Granada, J.R

2009-01-01

A new scattering kernel to describe the interaction of slow neutrons with solid Deuterium was developed. The main characteristics of that system are contained in the formalism, including the lattice s density of states, the Young-Koppel quantum treatment of the rotations, and the internal molecular vibrations. The elastic processes involving coherent and incoherent contributions are fully described, as well as the spin-correlation effects. The results from the new model are compared with the best available experimental data, showing very good agreement. [es

Analytical model and application of stress distribution on mining coal floor

Institute of Scientific and Technical Information of China (English)

ZHU Shu-yun; JIAN Zhen-quan; HOU Hong-liang; XIAO Wei-guo; YAO Pu

2008-01-01

Given the analysis of underground pressure, a stress calculation model of coal floor stress has been established based on a theory of elasticity. The model presents the law of stress distribution on the relatively fixed position of the mining coal floor: the extent of stress variation in a fixed floor position decreases gradually along with depth, the decreasing rate of the vertical stress is clearly larger than that of the horizontal stress at a specific depth. The direction of the maximum principal stress changes gradually from a vertical direction to a horizontal direction with the advance of the working face. The deformation and permeability of the rock mass of the coal floor are obtained by contrasting the difference of the principal stress established from theoretical calculations with curves of stress-strain and permeability-strain from tests, which is an important mechanical basis for preventing water inrush from confined aquifers.

Stress transfer modeling in CNT reinforced composites using continuum mechanics

International Nuclear Information System (INIS)

Chaboki Khiabani, A.; Sadrnejad, S. A.; Yahyaeii, M.

2008-01-01

Because of the substantial difference in stiffness between matrix and nano tube in CNT composite, the stress transfer between them controls their mechanical properties. This paper investigates the said issue, analytically and numerically, in axial load using representative volume element. The analytical model was established based on the modified Cox's shear lag model with the use of some simplified assumptions. Some, in the developed shear lag model, the CNT assumes hollow fiber. Solving the governing differential equation. led the high shear stress, in interface especially in the CNT cap. In addition, some finite element models were performed with different aspect ratios and the shear stress pattern especially in interface was calculated numerically. Despite some simplified assumptions that were performed with these two models such as elastic behavior and full connectivity, and the comparison of their results with other numerical models show adequate agreement

A nonlinear beam model to describe the postbuckling of wide neo-Hookean beams

Science.gov (United States)

Lubbers, Luuk A.; van Hecke, Martin; Coulais, Corentin

2017-09-01

Wide beams can exhibit subcritical buckling, i.e. the slope of the force-displacement curve can become negative in the postbuckling regime. In this paper, we capture this intriguing behaviour by constructing a 1D nonlinear beam model, where the central ingredient is the nonlinearity in the stress-strain relation of the beams constitutive material. First, we present experimental and numerical evidence of a transition to subcritical buckling for wide neo-Hookean hyperelastic beams, when their width-to-length ratio exceeds a critical value of 12%. Second, we construct an effective 1D energy density by combining the Mindlin-Reissner kinematics with a nonlinearity in the stress-strain relation. Finally, we establish and solve the governing beam equations to analytically determine the slope of the force-displacement curve in the postbuckling regime. We find, without any adjustable parameters, excellent agreement between the 1D theory, experiments and simulations. Our work extends the understanding of the postbuckling of structures made of wide elastic beams and opens up avenues for the reverse-engineering of instabilities in soft and metamaterials.

Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia

Directory of Open Access Journals (Sweden)

Patricia P. Jumbo-Lucioni

2013-01-01

Classic galactosemia is a genetic disorder that results from profound loss of galactose-1P-uridylyltransferase (GALT. Affected infants experience a rapid escalation of potentially lethal acute symptoms following exposure to milk. Dietary restriction of galactose prevents or resolves the acute sequelae; however, many patients experience profound long-term complications. Despite decades of research, the mechanisms that underlie pathophysiology in classic galactosemia remain unclear. Recently, we developed a Drosophila melanogaster model of classic galactosemia and demonstrated that, like patients, GALT-null Drosophila succumb in development if exposed to galactose but live if maintained on a galactose-restricted diet. Prior models of experimental galactosemia have implicated a possible association between galactose exposure and oxidative stress. Here we describe application of our fly genetic model of galactosemia to the question of whether oxidative stress contributes to the acute galactose sensitivity of GALT-null animals. Our first approach tested the impact of pro- and antioxidant food supplements on the survival of GALT-null and control larvae. We observed a clear pattern: the oxidants paraquat and DMSO each had a negative impact on the survival of mutant but not control animals exposed to galactose, and the antioxidants vitamin C and α-mangostin each had the opposite effect. Biochemical markers also confirmed that galactose and paraquat synergistically increased oxidative stress on all cohorts tested but, interestingly, the mutant animals showed a decreased response relative to controls. Finally, we tested the expression levels of two transcripts responsive to oxidative stress, GSTD6 and GSTE7, in mutant and control larvae exposed to galactose and found that both genes were induced, one by more than 40-fold. Combined, these results implicate oxidative stress and response as contributing factors in the acute galactose sensitivity of GALT-null Drosophila and, by

Thyro-stress.

Science.gov (United States)

Kalra, Sanjay; Verma, Komal; Balhara, Yatan Pal Singh

2017-01-01

Our understanding of the biopsychosocial model of health, and its influence on chronic endocrine conditions, has improved over the past few decades. We can distinguish, for example, between diabetes distress and major depressive disorders in diabetes. Similar to diabetes distress, we suggest the existence of "thyrostress" in chronic thyroid disorders. Thyro-stress is defined as an emotional state, characterized by extreme apprehension, discomfort or dejection, caused by the challenges and demand of living with thyroid disorders such as hypothyroidism. This communication describes the etiology, clinical features, differential diagnosis, and management of thyro-stress.

Welding stresses

International Nuclear Information System (INIS)

Poirier, J.; Barbe, B.; Jolly, N.

1976-01-01

The aim is to show how internal stresses are generated and to fix the orders of magnitude. A realistic case, the vertical welding of thick plates free to move one against the other, is described and the deformations and stresses are analyzed. The mathematical model UEDA, which accounts for the elastic modulus, the yield strength and the expansion coefficient of the metal with temperature, is presented. The hypotheses and results given apply only to the instantaneous welding of a welded plate and to a plate welded by a moving electrode [fr

Modelling of stress corrosion cracking in zirconium alloys

International Nuclear Information System (INIS)

Fandeur, O.; Rouillon, L.; Pilvin, P.; Jacques, P.; Rebeyrolle, V.

2001-01-01

During normal and incidental operating conditions, PWR power plants must comply with the first safety requirement, which is to ensure that the cladding wall is sound. Indeed some severe power transients potentially induce Stress Corrosion Cracking (SCC) of the zirconium alloy clad, due to strong Pellet Cladding Interaction (PCI). Since, at present, the prevention of this risk has some consequences on the French reactors manoeuvrability, a better understanding and forecast of the clad damage related to SCC/PCI is needed. With this aim, power ramp tests are performed in experimental reactors to assess the fuel rod behaviour and evaluate PCI failure risks. To study in detail SCC mechanisms, additional laboratory experiments are carried out on non-irradiated and irradiated cladding tubes. Numerical simulations of these tests have been developed aiming, on the one hand, to evaluate mechanical state variables and, on the other hand, to study consistent mechanical parameters for describing stress corrosion clad failure. The main result of this simulation is the determination of the validity ranges of the stress intensity factor, which is frequently used to model SCC. This parameter appears to be valid only at the onset of crack growth, when crack length remains short. In addition, the role of plastic strain rate and plastic strain as controlling parameters of the SCC process has been analysed in detail using the above mechanical description of the crack tip mechanical fields. Finally, the numerical determination of the first-order parameter(s) in the crack propagation rate law is completed by the development of laboratory tests focused on these parameters. These tests aim to support experimentally the results of the FE simulation. (author)

Using concept maps to describe undergraduate students’ mental model in microbiology course

Science.gov (United States)

Hamdiyati, Y.; Sudargo, F.; Redjeki, S.; Fitriani, A.

2018-05-01

The purpose of this research was to describe students’ mental model in a mental model based-microbiology course using concept map as assessment tool. Respondents were 5th semester of undergraduate students of Biology Education of Universitas Pendidikan Indonesia. The mental modelling instrument used was concept maps. Data were taken on Bacteria sub subject. A concept map rubric was subsequently developed with a maximum score of 4. Quantitative data was converted into a qualitative one to determine mental model level, namely: emergent = score 1, transitional = score 2, close to extended = score 3, and extended = score 4. The results showed that mental model level on bacteria sub subject before the implementation of mental model based-microbiology course was at the transitional level. After implementation of mental model based-microbiology course, mental model was at transitional level, close to extended, and extended. This indicated an increase in the level of students’ mental model after the implementation of mental model based-microbiology course using concept map as assessment tool.

Structural Models Describing Placebo Treatment Effects in Schizophrenia and Other Neuropsychiatric Disorders

NARCIS (Netherlands)

Reddy, Venkatesh Pilla; Kozielska, Magdalena; Johnson, Martin; Vermeulen, An; de Greef, Rik; Liu, Jing; Groothuis, Geny M. M.; Danhof, Meindert; Proost, Johannes H.

2011-01-01

Large variation in placebo response within and among clinical trials can substantially affect conclusions about the efficacy of new medications in psychiatry. Developing a robust placebo model to describe the placebo response is important to facilitate quantification of drug effects, and eventually

Using the reactive scope model to understand why stress physiology predicts survival during starvation in Galápagos marine iguanas.

Science.gov (United States)

Romero, L Michael

2012-05-01

Even though the term "stress" is widely used, a precise definition is notoriously difficult. Notwithstanding this difficulty, stress continues to be an important concept in biology because it attempts to describe how animals cope with environmental change under emergency conditions. Without a precise definition, however, it becomes nearly impossible to make testable a priori predictions about how physiological and hormonal systems will respond to emergency conditions and what the ultimate impact on the animal will be. The reactive scope model is a recent attempt to formulate testable predictions. This model provides a physiological basis to explain why corticosterone negative feedback, but not baseline corticosterone concentrations, corticosterone responses to acute stress, or the interrenal capacity to secrete corticosterone, is correlated with survival during famine conditions in Galápagos marine iguanas. Reactive scope thus provides a foundation for interpreting and predicting physiological stress responses. Copyright © 2011 Elsevier Inc. All rights reserved.

Image decomposition as a tool for validating stress analysis models

Directory of Open Access Journals (Sweden)

Mottershead J.

2010-06-01

Full Text Available It is good practice to validate analytical and numerical models used in stress analysis for engineering design by comparison with measurements obtained from real components either in-service or in the laboratory. In reality, this critical step is often neglected or reduced to placing a single strain gage at the predicted hot-spot of stress. Modern techniques of optical analysis allow full-field maps of displacement, strain and, or stress to be obtained from real components with relative ease and at modest cost. However, validations continued to be performed only at predicted and, or observed hot-spots and most of the wealth of data is ignored. It is proposed that image decomposition methods, commonly employed in techniques such as fingerprinting and iris recognition, can be employed to validate stress analysis models by comparing all of the key features in the data from the experiment and the model. Image decomposition techniques such as Zernike moments and Fourier transforms have been used to decompose full-field distributions for strain generated from optical techniques such as digital image correlation and thermoelastic stress analysis as well as from analytical and numerical models by treating the strain distributions as images. The result of the decomposition is 101 to 102 image descriptors instead of the 105 or 106 pixels in the original data. As a consequence, it is relatively easy to make a statistical comparison of the image descriptors from the experiment and from the analytical/numerical model and to provide a quantitative assessment of the stress analysis.

Ordinal regression models to describe tourist satisfaction with Sintra's world heritage

Science.gov (United States)

Mouriño, Helena

2013-10-01

In Tourism Research, ordinal regression models are becoming a very powerful tool in modelling the relationship between an ordinal response variable and a set of explanatory variables. In August and September 2010, we conducted a pioneering Tourist Survey in Sintra, Portugal. The data were obtained by face-to-face interviews at the entrances of the Palaces and Parks of Sintra. The work developed in this paper focus on two main points: tourists' perception of the entrance fees; overall level of satisfaction with this heritage site. For attaining these goals, ordinal regression models were developed. We concluded that tourist's nationality was the only significant variable to describe the perception of the admission fees. Also, Sintra's image among tourists depends not only on their nationality, but also on previous knowledge about Sintra's World Heritage status.

Gender Differences in Animal Models of Posttraumatic Stress Disorder

Directory of Open Access Journals (Sweden)

Hagit Cohen

2011-01-01

Full Text Available Epidemiological studies report higher prevalence rates of stress-related disorders such as acute stress disorder and post-traumatic stress disorder (PTSD in women than in men following exposure to trauma. It is still not clear whether this greater prevalence in woman reflects a greater vulnerability to stress-related psychopathology. A number of individual and trauma-related characteristics have been hypothesized to contribute to these gender differences in physiological and psychological responses to trauma, differences in appraisal, interpretation or experience of threat, coping style or social support. In this context, the use of an animal model for PTSD to analyze some of these gender-related differences may be of particular utility. Animal models of PTSD offer the opportunity to distinguish between biological and socio-cultural factors, which so often enter the discussion about gender differences in PTSD prevalence.

Methods and Models of Market Risk Stress-Testing of the Portfolio of Financial Instruments

Directory of Open Access Journals (Sweden)

Alexander M. Karminsky

2015-01-01

Full Text Available Amid instability of financial markets and macroeconomic situation the necessity of improving bank risk-management instrument arises. New economic reality defines the need for searching for more advanced approaches of estimating banks vulnerability to exceptional, but plausible events. Stress-testing belongs to such instruments. The paper reviews and compares the models of market risk stress-testing of the portfolio of different financial instruments. These days the topic of the paper is highly acute due to the fact that now stress-testing is becoming an integral part of anticrisis risk-management amid macroeconomic instability and appearance of new risks together with close interest to the problem of risk-aggregation. The paper outlines the notion of stress-testing and gives coverage of goals, functions of stress-tests and main criteria for market risk stress-testing classification. The paper also stresses special aspects of scenario analysis. Novelty of the research is explained by elaborating the programme of aggregated complex multifactor stress-testing of the portfolio risk based on scenario analysis. The paper highlights modern Russian and foreign models of stress-testing both on solo-basis and complex. The paper lays emphasis on the results of stress-testing and revaluations of positions for all three complex models: methodology of the Central Bank of stress-testing portfolio risk, model relying on correlations analysis and copula model. The models of stress-testing on solo-basis are different for each financial instrument. Parametric StressVaR model is applicable to shares and options stress-testing;model based on "Grek" indicators is used for options; for euroobligation regional factor model is used. Finally some theoretical recommendations about managing market risk of the portfolio are given.

Modelling of the Global Geopotential Energy & Stress Field

DEFF Research Database (Denmark)

Schiffer, Christian; Nielsen, S.B.

Lateral density and topography variations yield in and important contribution to the lithospheric stress field. The leading quantity is the Geopotential Energy, the integrated lithostatic pressure in a rock column. The horizontal gradient of this quantity is related to horizontal stresses through...... the Equations of equilibrium of stresses. The Geopotential Energy furthermore can be linearly related to the Geoid under assumption of local isostasy. Satellite Geoid measurements contain, however, also non-isostatic deeper mantle responses of long wavelength. Unfortunately, high-pass filtering of the Geoid...... flow in the presence of local isostasy and a steady state geotherm. Subsequently we use a FEM code to solve the Equations of equilibrium of stresses for a three dimensional elastic shell. The modelled results are shown and compared with the global stress field and other publications....

Validation of Weld Residual Stress Modeling in the NRC International Round Robin Study

International Nuclear Information System (INIS)

Mullins, Jonathan; Gunnars, Jens

2013-01-01

Weld residual stresses (WRS) have a large influence on the behavior of cracks growing under normal operation loads and on the leakage flow from a through-wall crack. Accurate prediction on weld residual stresses is important to make proper decisions when cracks in weld joints are detected. During the latest years, there has been a strong development in both analytical procedures to numerically determine WRS and experimental measurements of WRS. The USNRC (United States Nuclear Regulatory Commission) has formed a program for validation of WRS predictions through comparison of numerically calculated residual stress fields in dissimilar welds measured by different methods. The present report describes the results of the project with special focus on the contribution from Inspecta Technology. Objectives: The principal objective of the project is to compare different WRS predictions for a dissimilar pipe weld with careful measurements on a mock-up weld. The results of the project will make it possible to make recommendations on computational procedures for WRS in dissimilar metal welds. Results: It is concluded that numerical analysis of weld residual stresses using the finite element method is very useful for the estimation of weld residual stresses in complex geometries and dissimilar metal welds. The validation study increases the understanding of uncertainties associated with different modeling approaches and helps to identify the most sensitive parameters

Stress and Fatigue Life Modeling of Cannon Breech Closures Including Effects of Material Strength and Residual Stress

National Research Council Canada - National Science Library

Underwood, John

2000-01-01

...; overload residual stress. Modeling of applied and residual stresses at the location of the fatigue failure site is performed by elastic-plastic finite element analysis using ABAQUS and by solid...

Stress relaxation analysis of single chondrocytes using porohyperelastic model based on AFM experiments

Directory of Open Access Journals (Sweden)

Trung Dung Nguyen

2014-01-01

Full Text Available Based on atomic force microscopytechnique, we found that the chondrocytes exhibits stress relaxation behavior. We explored the mechanism of this stress relaxation behavior and concluded that the intracellular fluid exuding out from the cells during deformation plays the most important role in the stress relaxation. We applied the inverse finite element analysis technique to determine necessary material parameters for porohyperelastic (PHE model to simulate stress relaxation behavior as this model is proven capable of capturing the non-linear behavior and the fluid-solid interaction during the stress relaxation of the single chondrocytes. It is observed that PHE model can precisely capture the stress relaxation behavior of single chondrocytes and would be a suitable model for cell biomechanics.

N-acetyl-L-cysteine prevents stress-induced desmin aggregation in cellular models of desminopathy.

Directory of Open Access Journals (Sweden)

Bertrand-David Segard

Full Text Available Mutations within the human desmin gene are responsible for a subcategory of myofibrillar myopathies called desminopathies. However, a single inherited mutation can produce different phenotypes within a family, suggesting that environmental factors influence disease states. Although several mouse models have been used to investigate organ-specific desminopathies, a more general mechanistic perspective is required to advance our knowledge toward patient treatment. To improve our understanding of disease pathology, we have developed cellular models to observe desmin behaviour in early stages of disease pathology, e.g., upon formation of cytoplasmic desmin aggregates, within an isogenic background. We cloned the wildtype and three mutant desmin cDNAs using a Tet-On Advanced® expression system in C2C12 cells. Mutations were selected based on positioning within desmin and capacity to form aggregates in transient experiments, as follows: DesS46Y (head domain; low aggregation, DesD399Y (central rod domain; high aggregation, and DesS460I (tail domain; moderate aggregation. Introduction of these proteins into a C2C12 background permitted us to compare between desmin variants as well as to determine the role of external stress on aggregation. Three different types of stress, likely encountered during muscle activity, were introduced to the cell models-thermal (heat shock, redox-associated (H2O2 and cadmium chloride, and mechanical (stretching stresses-after which aggregation was measured. Cells containing variant DesD399Y were more sensitive to stress, leading to marked cytoplasmic perinuclear aggregations. We then evaluated the capacity of biochemical compounds to prevent this aggregation, applying dexamethasone (an inducer of heat shock proteins, fisetin or N-acetyl-L-cysteine (antioxidants before stress induction. Interestingly, N-acetyl-L-cysteine pre-treatment prevented DesD399Y aggregation during most stress. N-acetyl-L-cysteine has recently been

Communication skills training: describing a new conceptual model.

Science.gov (United States)

Brown, Richard F; Bylund, Carma L

2008-01-01

Current research in communication in physician-patient consultations is multidisciplinary and multimethodological. As this research has progressed, a considerable body of evidence on the best practices in physician-patient communication has been amassed. This evidence provides a foundation for communication skills training (CST) at all levels of medical education. Although the CST literature has demonstrated that communication skills can be taught, one critique of this literature is that it is not always clear which skills are being taught and whether those skills are matched with those being assessed. The Memorial Sloan-Kettering Cancer Center Comskil Model for CST seeks to answer those critiques by explicitly defining the important components of a consultation, based on Goals, Plans, and Actions theories and sociolinguistic theory. Sequenced guidelines as a mechanism for teaching about particular communication challenges are adapted from these other methods. The authors propose that consultation communication can be guided by an overarching goal, which is achieved through the use of a set of predetermined strategies. Strategies are common in CST; however, strategies often contain embedded communication skills. These skills can exist across strategies, and the Comskil Model seeks to make them explicit in these contexts. Separate from the skills are process tasks and cognitive appraisals that need to be addressed in teaching. The authors also describe how assessment practices foster concordance between skills taught and those assessed through careful coding of trainees' communication encounters and direct feedback.

Anisotropic generalization of well-known solutions describing relativistic self-gravitating fluid systems. An algorithm

Energy Technology Data Exchange (ETDEWEB)

Thirukkanesh, S. [Eastern University, Department of Mathematics, Chenkalady (Sri Lanka); Ragel, F.C. [Eastern University, Department of Physics, Chenkalady (Sri Lanka); Sharma, Ranjan; Das, Shyam [P.D. Women' s College, Department of Physics, Jalpaiguri (India)

2018-01-15

We present an algorithm to generalize a plethora of well-known solutions to Einstein field equations describing spherically symmetric relativistic fluid spheres by relaxing the pressure isotropy condition on the system. By suitably fixing the model parameters in our formulation, we generate closed-form solutions which may be treated as an anisotropic generalization of a large class of solutions describing isotropic fluid spheres. From the resultant solutions, a particular solution is taken up to show its physical acceptability. Making use of the current estimate of mass and radius of a known pulsar, the effects of anisotropic stress on the gross physical behaviour of a relativistic compact star is also highlighted. (orig.)

Constitutive Modeling of the Flow Stress of GCr15 Continuous Casting Bloom in the Heavy Reduction Process

Science.gov (United States)

Ji, Cheng; Wang, Zilin; Wu, Chenhui; Zhu, Miaoyong

2018-04-01

According to the calculation results of a 3D thermomechanical-coupled finite-element (FE) model of GCr15 bearing steel bloom during a heavy reduction (HR) process, the variation ranges in the strain rate and strain under HR were described. In addition, the hot deformation behavior of the GCr15 bearing steel was studied over the temperature range from 1023 K to 1573 K (750 °C to 1300 °C) with strain rates of 0.001, 0.01, and 0.1 s-1 in single-pass thermosimulation compression experiments. To ensure the accuracy of the constitutive model, the temperature range was divided into two temperature intervals according to the fully austenitic temperature of GCr15 steel [1173 K (900 °C)]. Two sets of material parameters for the constitutive model were derived based on the true stress-strain curves of the two temperature intervals. A flow stress constitutive model was established using a revised Arrhenius-type constitutive equation, which considers the relationships among the material parameters and true strain. This equation describes dynamic softening during hot compression processes. Considering the effect of glide and climb on the deformation mechanism, the Arrhenius-type constitutive equation was modified by a physically based approach. This model is the most accurate over the temperatures ranging from 1173 K to 1573 K (900 °C to 1300 °C) under HR deformation conditions (ignoring the range from 1273 K to 1573 K (1000 °C to 1300 °C) with a strain rate of 0.1 s-1). To ensure the convergence of the FE calculation, an approximated method was used to estimate the flow stress at temperatures greater than 1573 K (1300 °C).

Soil Compressibility Models for a Wide Stress Range

KAUST Repository

Chong, Song-Hun; Santamarina, Carlos

2016-01-01

Soil compressibility models with physically correct asymptotic void ratios are required to analyze situations that involve a wide stress range. Previously suggested models and other functions are adapted to satisfy asymptotic void ratios at low

Cytokine production as a putative biological mechanism underlying stress sensitization in high combat exposed soldiers

NARCIS (Netherlands)

Smid, Geert E.; van Zuiden, Mirjam; Geuze, Elbert; Kavelaars, Annemieke; Heijnen, Cobi J.; Vermetten, Eric

2015-01-01

Objective: Combat stress exposed soldiers may respond to post-deployment stressful life events (SLE) with increases in symptoms of posttraumatic stress disorder (PTSD), consistent with a model of stress sensitization. Several lines of research point to sensitization as a model to describe the

Transient Heating and Thermomechanical Stress Modeling of Ceramic HEPA Filters

Energy Technology Data Exchange (ETDEWEB)

Bogle, Brandon [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kelly, James [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Haslam, Jeffrey [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-09-29

The purpose of this report is to showcase an initial finite-element analysis model of a ceramic High-Efficiency Particulate (HEPA) Air filter design. Next generation HEPA filter assemblies are being developed at LLNL to withstand high-temperature fire scenarios by use of ceramics and advanced materials. The filters are meant for use in radiological and nuclear facilities, and are required to survive 500°C fires over an hour duration. During such conditions, however, collecting data under varying parameters can be challenging; therefore, a Finite Element Analysis model of the filter was conducted using COMSOL ® Multiphysics to analyze the effects of fire. Finite Element Analysis (FEA) modelling offers several opportunities: researchers can quickly and easily consider impacts of potential design changes, material selection, and flow characterization on filter performance. Specifically, this model provides stress references for the sealant at high temperatures. Modeling of full filter assemblies was deemed inefficient given the computational requirements, so a section of three tubes from the assembly was modeled. The model looked at the transient heating and thermomechanical stress development during a 500°C air flow at 6 CFM. Significant stresses were found at the ceramic-metal interfaces of the filter, and conservative temperature profiles at locations of interest were plotted. The model can be used for the development of sealants that minimize stresses at the ceramic-metal interface. Further work on the model would include the full filter assembly and consider heat losses to make more accurate predictions.

An algorithm to detect and communicate the differences in computational models describing biological systems.

Science.gov (United States)

Scharm, Martin; Wolkenhauer, Olaf; Waltemath, Dagmar

2016-02-15

Repositories support the reuse of models and ensure transparency about results in publications linked to those models. With thousands of models available in repositories, such as the BioModels database or the Physiome Model Repository, a framework to track the differences between models and their versions is essential to compare and combine models. Difference detection not only allows users to study the history of models but also helps in the detection of errors and inconsistencies. Existing repositories lack algorithms to track a model's development over time. Focusing on SBML and CellML, we present an algorithm to accurately detect and describe differences between coexisting versions of a model with respect to (i) the models' encoding, (ii) the structure of biological networks and (iii) mathematical expressions. This algorithm is implemented in a comprehensive and open source library called BiVeS. BiVeS helps to identify and characterize changes in computational models and thereby contributes to the documentation of a model's history. Our work facilitates the reuse and extension of existing models and supports collaborative modelling. Finally, it contributes to better reproducibility of modelling results and to the challenge of model provenance. The workflow described in this article is implemented in BiVeS. BiVeS is freely available as source code and binary from sems.uni-rostock.de. The web interface BudHat demonstrates the capabilities of BiVeS at budhat.sems.uni-rostock.de. © The Author 2015. Published by Oxford University Press.

On the modelling of semi-insulating GaAs including surface tension and bulk stresses

Energy Technology Data Exchange (ETDEWEB)

Dreyer, W.; Duderstadt, F.

2004-07-01

Necessary heat treatment of single crystal semi-insulating Gallium Arsenide (GaAs), which is deployed in micro- and opto- electronic devices, generate undesirable liquid precipitates in the solid phase. The appearance of precipitates is influenced by surface tension at the liquid/solid interface and deviatoric stresses in the solid. The central quantity for the description of the various aspects of phase transitions is the chemical potential, which can be additively decomposed into a chemical and a mechanical part. In particular the calculation of the mechanical part of the chemical potential is of crucial importance. We determine the chemical potential in the framework of the St. Venant-Kirchhoff law which gives an appropriate stress/strain relation for many solids in the small strain regime. We establish criteria, which allow the correct replacement of the St. Venant-Kirchhoff law by the simpler Hooke law. The main objectives of this study are: (i) We develop a thermo-mechanical model that describes diffusion and interface motion, which both are strongly influenced by surface tension effects and deviatoric stresses. (ii) We give an overview and outlook on problems that can be posed and solved within the framework of the model. (iii) We calculate non-standard phase diagrams, i.e. those that take into account surface tension and non-deviatoric stresses, for GaAs above 786 C, and we compare the results with classical phase diagrams without these phenomena. (orig.)

Investigation of an alternative generic model for predicting pharmacokinetic changes during physiological stress.

Science.gov (United States)

Peng, Henry T; Edginton, Andrea N; Cheung, Bob

2013-10-01

Physiologically based pharmacokinetic models were developed using MATLAB Simulink® and PK-Sim®. We compared the capability and usefulness of these two models by simulating pharmacokinetic changes of midazolam under exercise and heat stress to verify the usefulness of MATLAB Simulink® as a generic PBPK modeling software. Although both models show good agreement with experimental data obtained under resting condition, their predictions of pharmacokinetics changes are less accurate in the stressful conditions. However, MATLAB Simulink® may be more flexible to include physiologically based processes such as oral absorption and simulate various stress parameters such as stress intensity, duration and timing of drug administration to improve model performance. Further work will be conducted to modify algorithms in our generic model developed using MATLAB Simulink® and to investigate pharmacokinetics under other physiological stress such as trauma. © The Author(s) 2013.

Cytokine production as a putative biological mechanism underlying stress sensitization in high combat exposed soldiers

NARCIS (Netherlands)

Smid, Geert E.; van Zuiden, Mirjam; Geuze, Elbert; Kavelaars, Annemieke; Heijnen, Cobi J.; Vermetten, Eric

2015-01-01

Combat stress exposed soldiers may respond to post-deployment stressful life events (SLE) with increases in symptoms of posttraumatic stress disorder (PTSD), consistent with a model of stress sensitization. Several lines of research point to sensitization as a model to describe the relations between

Two-stage unified stretched-exponential model for time-dependence of threshold voltage shift under positive-bias-stresses in amorphous indium-gallium-zinc oxide thin-film transistors

Science.gov (United States)

Jeong, Chan-Yong; Kim, Hee-Joong; Hong, Sae-Young; Song, Sang-Hun; Kwon, Hyuck-In

2017-08-01

In this study, we show that the two-stage unified stretched-exponential model can more exactly describe the time-dependence of threshold voltage shift (ΔV TH) under long-term positive-bias-stresses compared to the traditional stretched-exponential model in amorphous indium-gallium-zinc oxide (a-IGZO) thin-film transistors (TFTs). ΔV TH is mainly dominated by electron trapping at short stress times, and the contribution of trap state generation becomes significant with an increase in the stress time. The two-stage unified stretched-exponential model can provide useful information not only for evaluating the long-term electrical stability and lifetime of the a-IGZO TFT but also for understanding the stress-induced degradation mechanism in a-IGZO TFTs.

Stress-based animal models of depression: Do we actually know what we are doing?

Science.gov (United States)

Yin, Xin; Guven, Nuri; Dietis, Nikolas

2016-12-01

Depression is one of the leading causes of disability and a significant health-concern worldwide. Much of our current understanding on the pathogenesis of depression and the pharmacology of antidepressant drugs is based on pre-clinical models. Three of the most popular stress-based rodent models are the forced swimming test, the chronic mild stress paradigm and the learned helplessness model. Despite their recognizable advantages and limitations, they are associated with an immense variability due to the high number of design parameters that define them. Only few studies have reported how minor modifications of these parameters affect the model phenotype. Thus, the existing variability in how these models are used has been a strong barrier for drug development as well as benchmark and evaluation of these pre-clinical models of depression. It also has been the source of confusing variability in the experimental outcomes between research groups using the same models. In this review, we summarize the known variability in the experimental protocols, identify the main and relevant parameters for each model and describe the variable values using characteristic examples. Our view of depression and our efforts to discover novel and effective antidepressants is largely based on our detailed knowledge of these testing paradigms, and requires a sound understanding around the importance of individual parameters to optimize and improve these pre-clinical models. Copyright © 2016 Elsevier B.V. All rights reserved.

Animal models of social stress: the dark side of social interactions.

Science.gov (United States)

Masis-Calvo, Marianela; Schmidtner, Anna K; de Moura Oliveira, Vinícius E; Grossmann, Cindy P; de Jong, Trynke R; Neumann, Inga D

2018-05-10

Social stress occurs in all social species, including humans, and shape both mental health and future interactions with conspecifics. Animal models of social stress are used to unravel the precise role of the main stress system - the HPA axis - on the one hand, and the social behavior network on the other, as these are intricately interwoven. The present review aims to summarize the insights gained from three highly useful and clinically relevant animal models of psychosocial stress: the resident-intruder (RI) test, the chronic subordinate colony housing (CSC), and the social fear conditioning (SFC). Each model brings its own focus: the role of the HPA axis in shaping acute social confrontations (RI test), the physiological and behavioral impairments resulting from chronic exposure to negative social experiences (CSC), and the neurobiology underlying social fear and its effects on future social interactions (SFC). Moreover, these models are discussed with special attention to the HPA axis and the neuropeptides vasopressin and oxytocin, which are important messengers in the stress system, in emotion regulation, as well as in the social behavior network. It appears that both nonapeptides balance the relative strength of the stress response, and simultaneously predispose the animal to positive or negative social interactions.

Experimental investigation of stresses and deformations of the model of a pod-boiler-prestressed concrete pressure vessel. Pt. 1

International Nuclear Information System (INIS)

Stoever, R.

1973-01-01

Investigations of elastic models are suitable to obtain independent values for stress states and deformations of thickwalled pressure vessels to check computer programs for three-dimensional elastic calculations. An elastic model of epoxy resin was constructed with the geometry of the pod boiler pressure vessel of the Hartlepool nuclear power station. With this model strains and deformations were measured for internal pressure. The stress states in the neighbourhood of the large vertical openings for the boiler pods and the horizontal gas ducts and at the junction of cylinder and plates were of special interest. Therefore most of the gauges were concentrated in these regions. A considerable number of strain gauges were embedded in the wall. The construction of the model is described in part one and results of the measurements are presented and discussed in part two of this report. (orig.) [de

Vision-based stress estimation model for steel frame structures with rigid links

Science.gov (United States)

Park, Hyo Seon; Park, Jun Su; Oh, Byung Kwan

2017-07-01

This paper presents a stress estimation model for the safety evaluation of steel frame structures with rigid links using a vision-based monitoring system. In this model, the deformed shape of a structure under external loads is estimated via displacements measured by a motion capture system (MCS), which is a non-contact displacement measurement device. During the estimation of the deformed shape, the effective lengths of the rigid link ranges in the frame structure are identified. The radius of the curvature of the structural member to be monitored is calculated using the estimated deformed shape and is employed to estimate stress. Using MCS in the presented model, the safety of a structure can be assessed gauge-freely. In addition, because the stress is directly extracted from the radius of the curvature obtained from the measured deformed shape, information on the loadings and boundary conditions of the structure are not required. Furthermore, the model, which includes the identification of the effective lengths of the rigid links, can consider the influences of the stiffness of the connection and support on the deformation in the stress estimation. To verify the applicability of the presented model, static loading tests for a steel frame specimen were conducted. By comparing the stress estimated by the model with the measured stress, the validity of the model was confirmed.

Modelling of the in situ stress state at Olkiluoto Site, Western Finland

International Nuclear Information System (INIS)

Valli, J.; Kuula, H.; Hakala, M.

2011-06-01

In order to determine the interaction of in situ stress and geological features at Olkiluoto with the ONKALO area under more specific focus, stress modelling work was launched in 2009. This entailed updating a previously used model geometry to suit current needs whilst also updating interpreted brittle deformation zones according to the data provided by Posiva in the beginning of 2010. The previous model geometry was originally used for seismic and glacial load simulations. Brittle deformation zones were updated in the model according to a new selection criterion which added a number of brittle deformation zones. Changes in the geometry of certain brittle deformation zones were also necessary to better fit the early 2010 interpretations from Posiva. Modelling goals were to clarify the effect of joint parameters on stress magnitude and orientation and which of the major brittle deformation zones detected in the ONKALO region could have potential effects on local in situ stress states. Additional goals included modelling the effect of several optional thrust boundary conditions and an ice-age. Compression from the northwest-southeast was used as the default approach whilst north-south, east-west and northeast-southwest were optional conditions. A simplified glaciation cycle was also simulated. Results were clear in demonstrating the critical effect of joint cohesion and joint friction angle, i.e. shear strength, on stress-geology interaction, essentially in this order of importance. The case that utilised both drillhole core-logging and ONKALO tunnel mapping results did not exhibit much if any stress-geology interactions as BFZ strength parameters were too high in order to allow any interactions to occur. The geometry and orientation of brittle deformation zones was found to be of significant importance; deformation zones with a shallow dip roughly in the direction of applied compression were optimal for causing stress rotations and the increase of stress magnitude

Thyro-stress

Directory of Open Access Journals (Sweden)

Sanjay Kalra

2017-01-01

Full Text Available Our understanding of the biopsychosocial model of health, and its influence on chronic endocrine conditions, has improved over the past few decades. We can distinguish, for example, between diabetes distress and major depressive disorders in diabetes. Similar to diabetes distress, we suggest the existence of “thyrostress” in chronic thyroid disorders. Thyro-stress is defined as an emotional state, characterized by extreme apprehension, discomfort or dejection, caused by the challenges and demand of living with thyroid disorders such as hypothyroidism. This communication describes the etiology, clinical features, differential diagnosis, and management of thyro-stress.

The role of sexual self-schema in a diathesis-stress model of sexual dysfunction.

Science.gov (United States)

Cyranowski, Jill M; Aarestad, Susan L; Andersen, Barbara L

1999-01-01

Sexual self-schemas are cognitive generalizations regarding sexual aspects of the self that represent a core component of one's sexuality. We contend that individual differences in the sexual self-view represent an important cognitive diathesis for predicting sexual difficulty or dysfunction. We illustrate the role of sexual self-schemas on sexual behavior and responsiveness in healthy female and male samples. Next, we describe how diathesis-stress models of psychopathology have been applied to the sexual arena, and discuss the critical features of clinically useful diathesis variables. Drawing from these criteria, we examine the diathetic properties of sexual self-schemas. Finally, we discuss an empirical test of the proposed diathesis-stress interaction, reviewing the role of women's sexual self-views on sexual morbidity following diagnosis and treatment for gynecologic cancer.

The role of sexual self-schema in a diathesis–stress model of sexual dysfunction

Science.gov (United States)

CYRANOWSKI, JILL M.; AARESTAD, SUSAN L.; ANDERSEN, BARBARA L.

2009-01-01

Sexual self-schemas are cognitive generalizations regarding sexual aspects of the self that represent a core component of one’s sexuality. We contend that individual differences in the sexual self-view represent an important cognitive diathesis for predicting sexual difficulty or dysfunction. We illustrate the role of sexual self-schemas on sexual behavior and responsiveness in healthy female and male samples. Next, we describe how diathesis–stress models of psychopathology have been applied to the sexual arena, and discuss the critical features of clinically useful diathesis variables. Drawing from these criteria, we examine the diathetic properties of sexual self-schemas. Finally, we discuss an empirical test of the proposed diathesis–stress interaction, reviewing the role of women’s sexual self-views on sexual morbidity following diagnosis and treatment for gynecologic cancer. PMID:19587834

Experimental determination of the stress/strain situation in a sheared tunnel model with canister

International Nuclear Information System (INIS)

Pusch, R.

1978-03-01

A previous report concerned a technical matter which could be of great importance as regards the mechanical strength of canisters embedded in a bentonite/quartz buffer mass, i.e. the effect of a differential movement triggered by a critical deviatoric stress condition. Even if this is extremely unlikeley to occur it was considered to be of importance to verify the theoretical expressions for the maximum bending moment and maximum shear force. A special reason was to test the hypothesis that the contact pressure would soon reach a high value and then stay fairly constant when the displacement increased. The theoretical approach requires that the stress/strain properties of the fill are thoroghly investigated and described in therms of a mathematical model. Experience shows that this may be a tedions and difficult task. (L.E.)

Tocopherol And Tocotrienol: Therapeutic Potential In Animal Models of Stress.

Science.gov (United States)

Azlina, Mohd Fahami Nur; Kamisah, Yusof; Qodriyah, Mohd Saad

2017-11-22

Scientific reports had shown that stress is related to numerous pathological changes in the body. These pathological changes can bring about numerous diseases and can significantly cause negative effects in an individual. These include gastric ulcer, liver pathology and neurobehavioral changes. A common pathogenesis in many diseases related to stress involves oxidative damage. Therefore, the administration of antioxidants such as vitamin E is a reasonable therapeutic approach. However, there is conflicting evidence about antioxidant supplementation. The aim of this work was to summarize documented reports on the effects of tocopherol and tocotrienol on various pathological changes induced by stress. This review will reveal the scientific evidence of enteral supplementation of vitamin E in the forms of tocotrienol and tocopherol in animal models of stress. These models mimic the stress endured by critically ill patients in a clinical setting and psychological stress in individuals. Positive outcomes from enteral feeding of vitamin E in reducing the occurrence of stress-induced pathological changes are discussed in this review. These positive findings include their ability to reduced stress-induced gastric ulcers, elevated liver enzymes and improved locomotors activity. Evidences showing tocotrienol and tocopherol effects are not just related to its ability to reduce oxidative stress but also acting on other mechanism are discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

A bottom-up model to describe consumers’ preferences towards late season peaches

Energy Technology Data Exchange (ETDEWEB)

Groot, E.; Albisu, L.M.

2015-07-01

Peaches are consumed in Mediterranean countries since ancient times. Nowadays there are few areas in Europe that produce peaches with Protected Designation of Origin (PDO), and the Calanda area is one of them. The aim of this work is to describe consumers’ preferences towards late season PDO Calanda peaches in the city of Zaragoza, Spain, by a bottom-up model. The bottom-up model proves greater amount of information than top-down models. In this approach it is estimated one utility function per consumer. Thus, it is not necessary to make assumptions about preference distributions and correlations across respondents. It was observed that preference distributions were neither normal nor independently distributed. If those preferences were estimated by top-down models, conclusions would be biased. This paper also explores a new way to describe preferences through individual utility functions. Results show that the largest behavioural group gathered origin sensitive consumers. Their utility increased if the peaches were produced in the Calanda area and, especially, when peaches had the PDO Calanda brand. In sequence, the second most valuable attribute for consumers was the price. Peach size and packaging were not so important on purchase choice decision. Nevertheless, it is advisable to avoid trading smallest size peaches (weighting around 160 g/fruit). Traders also have to be careful by using active packaging. It was found that a group of consumers disliked this kind of product, probably, because they perceived it as less natural. (Author)

finite element model for predicting residual stresses in shielded

African Journals Online (AJOL)

eobe

This paper investigates the prediction of residual stresses developed ... steel plates through Finite Element Model simulation and experiments. ... The experimental values as measured by the X-Ray diffractometer were of ... Based on this, it can be concluded that Finite Element .... Comparison of Residual Stresses from X.

A nonlinear magnetoelectric model for magnetoelectric layered composite with coupling stress

International Nuclear Information System (INIS)

Shi, Yang; Gao, Yuanwen

2014-01-01

Based on a linear piezoelectric relation and a nonlinear magnetostrictive constitutive relation, A nonlinear magnetoelectric (ME) effect model for flexural layered ME composites is established in in-plane magnetic field. In the proposed model, the true coupling stress and the equivalent piezomagnetic coefficient are taken into account and obtained through an iterative approach. Some calculations on nonlinear ME coefficient are conducted and discussed. Our results show that for both the flexural bilayer and trilayer composites, the true coupling stress in the composites first increase and then approach to a constant value with the increase of applied magnetic fields, affecting the nonlinear ME effect significantly. With consideration of the true coupling stress, the ME effect is smaller than that without consideration of the true coupling stress. Moreover, the proposed theoretical model predicts that the ME coefficient of the trilayer composite (does not generate the bending deflection) is much larger than that of bilayer composite (generates the bending deflection), which is in well agreement with the previous works. The influences of the applied magnetic field on the true coupling stress and fraction ratio corresponding to the extreme ME coefficients of layered structures are also investigated. - Highlights: • This paper develops a nonlinear model for layered ME composite. • The true coupling stress is obtained through an iterative approach. • The influences of coupling stress and flexural deformation are discussed. • The dependence of ME coefficient on magnetic field is studied

Comparison of six different models describing survival of mammalian cells after irradiation

International Nuclear Information System (INIS)

Sontag, W.

1990-01-01

Six different cell-survival models have been compared. All models are based on the similar assumption that irradiated cells are able to exist in one of three states. S A is the state of a totally repaired cell, in state S C the cell contains lethal lesions and in state S b the cell contains potentially lethal lesions i.e. those which either can be repaired or converted into lethal lesions. The differences between the six models lie in the different mathematical relationships between the three states. To test the six models, six different sets of experimental data were used which describe cell survival at different repair times after irradiation with sparsely ionizing irradiation. In order to compare the models, a goodness-of-fit function was used. The differences between the six models were tested by use of the nonparametric Mann-Whitney two sample test. Based on the 95% confidence limit, this required separation into three groups. (orig.)

Stress and adaptation : Toward ecologically relevant animal models

NARCIS (Netherlands)

Koolhaas, Jaap M.; Boer, Sietse F. de; Buwalda, Bauke

Animal models have contributed considerably to the current understanding of mechanisms underlying the role of stress in health and disease. Despite the progress made already, much more can be made by more carefully exploiting animals' and humans' shared biology, using ecologically relevant models.

A revised multi-Fickian moisture transport model to describe non-Fickian effects in wood

DEFF Research Database (Denmark)

Frandsen, Henrik Lund; Damkilde, Lars; Svensson, Staffan

2007-01-01

This paper presents a study and a refinement of the sorption rate model in a so-called multi-Fickian or multi-phase model. This type of model describes the complex moisture transport system in wood, which consists of separate water vapor and bound-water diffusion interacting through sorption...... sorption allow a simplification of the system to be modeled by a single Fickian diffusion equation. To determine the response of the system, the sorption rate model is essential. Here the function modeling the moisture-dependent adsorption rate is investigated based on existing experiments on thin wood...

Stress categorization in nozzle to pressure vessel connections finite elements models

International Nuclear Information System (INIS)

Albuquerque, Levi Barcelos de

1999-01-01

The ASME Boiler and Pressure Vessel Code, Section III , is the most important code for nuclear pressure vessels design. Its design criteria were developed to preclude the various pressure vessel failure modes throughout the so-called 'Design by Analysis', some of them by imposing stress limits. Thus, failure modes such as plastic collapse, excessive plastic deformation and incremental plastic deformation under cyclic loading (ratchetting) may be avoided by limiting the so-called primary and secondary stresses. At the time 'Design by Analysis' was developed (early 60's) the main tool for pressure vessel design was the shell discontinuity analysis, in which the results were given in membrane and bending stress distributions along shell sections. From that time, the Finite Element Method (FEM) has had a growing use in pressure vessels design. In this case, the stress results are neither normally separated in membrane and bending stress nor classified in primary and secondary stresses. This process of stress separation and classification in Finite Element (FE) results is what is called stress categorization. In order to perform the stress categorization to check results from FE models against the ASME Code stress limits, mainly from 3D solid FE models, several research works have been conducted. This work is included in this effort. First, a description of the ASME Code design criteria is presented. After that, a brief description of how the FEM can be used in pressure vessel design is showed. Several studies found in the literature on stress categorization for pressure vessel FE models are reviewed and commented. Then, the analyses done in this work are presented in which some typical nozzle to pressure vessel connections subjected to internal pressure and concentrated loads were modeled with solid finite elements. The results from linear elastic and limit load analyses are compared to each other and also with the results obtained by formulae for simple shell

A relativistic gauge model describing N particles bound by harmonic forces

International Nuclear Information System (INIS)

Filippov, A.T.

1987-01-01

Application of the principle of gauging to linear canonical symmetries of simplest/rudimentary/bilinear lagrangians is shown to produce a relativistic version of the Lagrangian describing N particles bound by harmonic forces. For pairwise coupled identical particles the gauge group is T 1 xU 1 , xSU N-1 . A model for the relativistic discrete string (a chain of N particles) is also discussed. All these gauge theoried of particles can be quantized by standard methods

Computational Psychometrics for Modeling System Dynamics during Stressful Disasters

Directory of Open Access Journals (Sweden)

Pietro Cipresso

2017-08-01

Full Text Available Disasters can be very stressful events. However, computational models of stress require data that might be very difficult to collect during disasters. Moreover, personal experiences are not repeatable, so it is not possible to collect bottom-up information when building a coherent model. To overcome these problems, we propose the use of computational models and virtual reality integration to recreate disaster situations, while examining possible dynamics in order to understand human behavior and relative consequences. By providing realistic parameters associated with disaster situations, computational scientists can work more closely with emergency responders to improve the quality of interventions in the future.

Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment

Science.gov (United States)

Bourke, Chase H.; Capello, Catherine F.; Rogers, Swati M.; Yu, Megan L.; Boss-Williams, Katherine A.; Weiss, Jay M.; Stowe, Zachary N.; Owens, Michael J.

2014-01-01

Rationale A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother. Objective The objective of this study was to develop a model of clinically relevant prenatal exposure to an antidepressant and stress during pregnancy to evaluate the effects on maternal care behavior. Results Female rats implanted with 28 day osmotic minipumps delivering the SSRI escitalopram throughout pregnancy had serum escitalopram concentrations in a clinically observed range (17-65 ng/mL). A separate cohort of pregnant females exposed to a chronic unpredictable mild stress paradigm on gestational days 10-20 showed elevated baseline (305 ng/mL), and acute stress-induced (463 ng/mL), plasma corticosterone concentrations compared to unstressed controls (109 ng/mL). A final cohort of pregnant dams were exposed to saline (control), escitalopram, stress, or stress and escitalopram to determine the effects on maternal care. Maternal behavior was continuously monitored over the first 10 days post parturition. A reduction of 35% in maternal contact and 11% in nursing behavior was observed due to stress during the light cycle. Licking and grooming behavior was unaffected by stress or drug exposure in either the light or dark cycle. Conclusions These data indicate that: 1) clinically relevant antidepressant treatment during human pregnancy can be modeled in rats using escitalopram; 2) chronic mild stress can be delivered in a manner that does not compromise fetal viability; and 3) neither of these prenatal treatments substantially altered maternal care post parturition. PMID:23436130

Gravity-driven groundwater flow and slope failure potential: 1. Elastic effective-stress model

Science.gov (United States)

Iverson, Richard M.; Reid, Mark E.

1992-01-01

Hilly or mountainous topography influences gravity-driven groundwater flow and the consequent distribution of effective stress in shallow subsurface environments. Effective stress, in turn, influences the potential for slope failure. To evaluate these influences, we formulate a two-dimensional, steady state, poroelastic model. The governing equations incorporate groundwater effects as body forces, and they demonstrate that spatially uniform pore pressure changes do not influence effective stresses. We implement the model using two finite element codes. As an illustrative case, we calculate the groundwater flow field, total body force field, and effective stress field in a straight, homogeneous hillslope. The total body force and effective stress fields show that groundwater flow can influence shear stresses as well as effective normal stresses. In most parts of the hillslope, groundwater flow significantly increases the Coulomb failure potential Φ, which we define as the ratio of maximum shear stress to mean effective normal stress. Groundwater flow also shifts the locus of greatest failure potential toward the slope toe. However, the effects of groundwater flow on failure potential are less pronounced than might be anticipated on the basis of a simpler, one-dimensional, limit equilibrium analysis. This is a consequence of continuity, compatibility, and boundary constraints on the two-dimensional flow and stress fields, and it points to important differences between our elastic continuum model and limit equilibrium models commonly used to assess slope stability.

Fundamental approaches to predicting stress corrosion: 'Quantitative micro-nano' (QMN) approach to predicting stress corrosion cracking in water cooled nuclear plants

International Nuclear Information System (INIS)

Staehle, R.W.

2010-01-01

This paper describes the modeling and experimental studies of stress corrosion cracking with full disciplinary set at the atomic level. Its objective is to develop an intellectual structure for quantitative prediction of stress corrosion cracking in water cooled reactors.

New model for surface fracture induced by dynamical stress

OpenAIRE

Andersen, J. V.; Lewis, L. J.

1997-01-01

We introduce a model where an isotropic, dynamically-imposed stress induces fracture in a thin film. Using molecular dynamics simulations, we study how the integrated fragment distribution function depends on the rate of change and magnitude of the imposed stress, as well as on temperature. A mean-field argument shows that the system becomes unstable for a critical value of the stress. We find a striking invariance of the distribution of fragments for fixed ratio of temperature and rate of ch...

Magneto-dependent stress relaxation of magnetorheological gels

KAUST Repository

Xu, Yangguang; Liu, Taixiang; Liao, G J; Lubineau, Gilles

2017-01-01

The stress relaxation behaviors of magnetorheological (MR) gels under stepwise shear loading are systematically investigated. The particle-enhanced effect, the magneto-induced effect, and the temperature-enhanced effect on the stress relaxation of MR gels are discussed. For further analysis of the magneto-induced stress relaxation mechanism in MR gels, a phenomenological model is established to describe the stress relaxation behavior of the matrix and the magnetic particle chains. All characteristic parameters introduced in the model, i.e. relaxation time, instantaneous modulus, and stable modulus, have well-defined physical meanings and are fitted based on the experimental results. The influence of each parameter on the macroscopic response is discussed and it is found that the relaxation stress induced by the magneto-mechanical coupling effect plays an important role in the stress relaxation process of MR gels.

Magneto-dependent stress relaxation of magnetorheological gels

KAUST Repository

Xu, Yangguang

2017-09-01

The stress relaxation behaviors of magnetorheological (MR) gels under stepwise shear loading are systematically investigated. The particle-enhanced effect, the magneto-induced effect, and the temperature-enhanced effect on the stress relaxation of MR gels are discussed. For further analysis of the magneto-induced stress relaxation mechanism in MR gels, a phenomenological model is established to describe the stress relaxation behavior of the matrix and the magnetic particle chains. All characteristic parameters introduced in the model, i.e. relaxation time, instantaneous modulus, and stable modulus, have well-defined physical meanings and are fitted based on the experimental results. The influence of each parameter on the macroscopic response is discussed and it is found that the relaxation stress induced by the magneto-mechanical coupling effect plays an important role in the stress relaxation process of MR gels.

Finite element modelling for fatigue stress analysis of large suspension bridges

Science.gov (United States)

Chan, Tommy H. T.; Guo, L.; Li, Z. X.

2003-03-01

Fatigue is an important failure mode for large suspension bridges under traffic loadings. However, large suspension bridges have so many attributes that it is difficult to analyze their fatigue damage using experimental measurement methods. Numerical simulation is a feasible method of studying such fatigue damage. In British standards, the finite element method is recommended as a rigorous method for steel bridge fatigue analysis. This paper aims at developing a finite element (FE) model of a large suspension steel bridge for fatigue stress analysis. As a case study, a FE model of the Tsing Ma Bridge is presented. The verification of the model is carried out with the help of the measured bridge modal characteristics and the online data measured by the structural health monitoring system installed on the bridge. The results show that the constructed FE model is efficient for bridge dynamic analysis. Global structural analyses using the developed FE model are presented to determine the components of the nominal stress generated by railway loadings and some typical highway loadings. The critical locations in the bridge main span are also identified with the numerical results of the global FE stress analysis. Local stress analysis of a typical weld connection is carried out to obtain the hot-spot stresses in the region. These results provide a basis for evaluating fatigue damage and predicting the remaining life of the bridge.

A Numerical Model for Prediction of Residual Stress Using Rayleigh Waves

International Nuclear Information System (INIS)

Yuan, Mao Dan; Kang, To; Kim, Hak Joon; Song, Sung Jin

2011-01-01

In this work, a numerical model is proposed for the relation between the magnitudes and the depth residual stress with the velocity of Rayleigh wave. Three cases, stress-free, uniform stress and layered stress, are investigated for the change tendency of the Rayleigh wave speed. Using the simulated signal with variation of residual stress magnitude and depth, investigation of the parameters for fitting residual stress and velocity change are performed. The speed change of Rayleigh wave shows a linear relation with the magnitude and an exponential relation with the depth of residual stress. The combination of these two effects could be used for the depth profile evaluation of the residual stress

Groundwater development stress: Global-scale indices compared to regional modeling

Science.gov (United States)

Alley, William; Clark, Brian R.; Ely, Matt; Faunt, Claudia

2018-01-01

The increased availability of global datasets and technologies such as global hydrologic models and the Gravity Recovery and Climate Experiment (GRACE) satellites have resulted in a growing number of global-scale assessments of water availability using simple indices of water stress. Developed initially for surface water, such indices are increasingly used to evaluate global groundwater resources. We compare indices of groundwater development stress for three major agricultural areas of the United States to information available from regional water budgets developed from detailed groundwater modeling. These comparisons illustrate the potential value of regional-scale analyses to supplement global hydrological models and GRACE analyses of groundwater depletion. Regional-scale analyses allow assessments of water stress that better account for scale effects, the dynamics of groundwater flow systems, the complexities of irrigated agricultural systems, and the laws, regulations, engineering, and socioeconomic factors that govern groundwater use. Strategic use of regional-scale models with global-scale analyses would greatly enhance knowledge of the global groundwater depletion problem.

Galacto-oligosaccharides exert a protective effect against heat stress in a Caco-2 cell model

NARCIS (Netherlands)

Varasteh, Soheil; Braber, Saskia; Garssen, Johan; Fink-Gremmels, Johanna

Thermal stress can evoke a stress response and enhance the synthesis of heat shock proteins, while gut barrier dysfunction is considered as an important adverse effect of thermal stress. Considering the previously described effects of galacto-oligosaccharides, nowadays mainly used in infant

Stress, overeating, and obesity: Insights from human studies and preclinical models.

Science.gov (United States)

Razzoli, Maria; Pearson, Carolyn; Crow, Scott; Bartolomucci, Alessandro

2017-05-01

Eating disorders and obesity have become predominant in human society. Their association to modern lifestyle, encompassing calorie-rich diets, psychological stress, and comorbidity with major diseases are well documented. Unfortunately the biological basis remains elusive and the pharmacological treatment inadequate, in part due to the limited availability of valid animal models. Human research on binge eating disorder (BED) proves a strong link between stress exposure and bingeing: state-levels of stress and negative affect are linked to binge eating in individuals with BED both in laboratory settings and the natural environment. Similarly, classical animal models of BED reveal an association between acute exposure to stressors and binging but they are often associated with unchanged or decreased body weight, thus reflecting a negative energy balance, which is uncommon in humans where most commonly BED is associated with excessive or unstable body weight gain. Recent mouse models of subordination stress induce spontaneous binging and hyperphagia, altogether more closely mimicking the behavioral and metabolic features of human BED. Therefore the translational relevance of subordination stress models could facilitate the identification of the neurobiological basis of BED and obesity-associated disease and inform on the development of innovative therapies. Copyright © 2017 Elsevier Ltd. All rights reserved.

Ecophysiological modeling of grapevine water stress in Burgundy terroirs by a machine-learning approach

Directory of Open Access Journals (Sweden)

Luca eBrillante

2016-06-01

Full Text Available In a climate change scenario, successful modeling of the relationships between plant-soil-meteorology is crucial for a sustainable agricultural production, especially for perennial crops. Grapevines (Vitis vinifera L. cv Chardonnay located in eight experimental plots (Burgundy, France along a hillslope were monitored weekly for three years for leaf water potentials, both at predawn (Ψpd and at midday (Ψstem. The water stress experienced by grapevine was modeled as a function of meteorological data (minimum and maximum temperature, rainfall and soil characteristics (soil texture, gravel content, slope by a gradient boosting machine. Model performance was assessed by comparison with carbon isotope discrimination (δ13C of grape sugars at harvest and by the use of a test-set. The developed models reached outstanding prediction performance (RMSE < 0.08 MPa for Ψstem and < 0.06 MPa for Ψpd, comparable to measurement accuracy. Model predictions at a daily time step improved correlation with δ13C data, respect to the observed trend at a weekly time scale. The role of each predictor in these models was described in order to understand how temperature, rainfall, soil texture, gravel content and slope affect the grapevine water status in the studied context. This work proposes a straight-forward strategy to simulate plant water stress in field condition, at a local scale; to investigate ecological relationships in the vineyard and adapt cultural practices to future conditions.

Ecophysiological Modeling of Grapevine Water Stress in Burgundy Terroirs by a Machine-Learning Approach.

Science.gov (United States)

Brillante, Luca; Mathieu, Olivier; Lévêque, Jean; Bois, Benjamin

2016-01-01

In a climate change scenario, successful modeling of the relationships between plant-soil-meteorology is crucial for a sustainable agricultural production, especially for perennial crops. Grapevines (Vitis vinifera L. cv Chardonnay) located in eight experimental plots (Burgundy, France) along a hillslope were monitored weekly for 3 years for leaf water potentials, both at predawn (Ψpd) and at midday (Ψstem). The water stress experienced by grapevine was modeled as a function of meteorological data (minimum and maximum temperature, rainfall) and soil characteristics (soil texture, gravel content, slope) by a gradient boosting machine. Model performance was assessed by comparison with carbon isotope discrimination (δ(13)C) of grape sugars at harvest and by the use of a test-set. The developed models reached outstanding prediction performance (RMSE < 0.08 MPa for Ψstem and < 0.06 MPa for Ψpd), comparable to measurement accuracy. Model predictions at a daily time step improved correlation with δ(13)C data, respect to the observed trend at a weekly time scale. The role of each predictor in these models was described in order to understand how temperature, rainfall, soil texture, gravel content and slope affect the grapevine water status in the studied context. This work proposes a straight-forward strategy to simulate plant water stress in field condition, at a local scale; to investigate ecological relationships in the vineyard and adapt cultural practices to future conditions.

Modelling of composition and stress profiles in low temperature surface engineered stainless steel

DEFF Research Database (Denmark)

Jespersen, Freja Nygaard; Hattel, Jesper Henri; Somers, Marcel A. J.

2015-01-01

temperature, time and gas composition is a prerequisite for targeted process optimization. A realistic model to simulate the developing case has to take the following influences on composition and stress into account: - a concentration dependent diffusion coefficient - trapping of nitrogen by chromium atoms...... stresses are introduced in the developing case, arising from the volume expansion that accompanies the dissolution of high interstitial contents in expanded austenite. Modelling of the composition and stress profiles developing during low temperature surface engineering from the processing parameters...... - the effect of residual stress on diffusive flux - the effect of residual stress on solubility of interstitials - plastic accommodation of residual stress. The effect of all these contributions on composition and stress profiles will be addressed....

Extension of the M-D model for treating stress drops in salt

International Nuclear Information System (INIS)

Munson, D.E.; DeVries, K.L.; Fossum, A.F.; Callahan, G.D.

1993-01-01

Development of the multimechanism deformation (M-D) constitutive model for steady state creep, which incorporates irreversible workhardening and recovery transient strains, was motivated by the need to predict very long term closures in underground rooms for radioactive waste repositories in salt. The multimechanism deformation model for the creep deformation of salt is extended to treat the response of salt to imposed stress drops. Stress drop tests produce a very distinctive behavior where both reversible elastic strain and reversible time dependent strain occur. These transient strains are negative compared to the positive transient strains produced by the normal creep workhardening and recovery processes. A simple micromechanical evolutionary process is defined to account for the accumulation of these reversible strains, and their subsequent release with decreases in stress. A number of experimental stress drop tests for various stress drop magnitudes and temperatures are adequately simulated with the model

Mapping residual stress by ultrasonic tomography

International Nuclear Information System (INIS)

Hildebrand, B.P.; Harrington, T.P.

1979-01-01

It is known that internal stress concentrations can give rise to microcracks which then grow when the structure is subjected to external forces. It has also been found that the velocity of sound is altered as it propagates through a region of stress. In this paper a technique called Computer-Assisted Tomography (CAT) is discussed and an application that provides pictures of stress fields is described. The results of both simulated and experimental models used to evaluate the technique are reported. It is concluded that the CAT approach has great potential for locating and mapping residual stress in metals. (author)

Stress associated with caregiving: an examination of the stress process model among Kenyan Luo elders.

Science.gov (United States)

Ice, Gillian H; Sadruddin, Aalyia F A; Vagedes, Amy; Yogo, Jaja; Juma, Elizabeth

2012-06-01

Globally, a growing number of grandparents are caring for their grandchildren. The impact and burden associated with increases in custodial grandparenting, however, may differ by culture. In the United States, the caregiving role has been shown to be a significant source of stress for older adults. In cultures in which grandparents are more commonly involved in the care of young children, however, increasing caregiving roles may not be viewed as stressful. This study examines the impact of caregiving on perceived and physiological measures of stress among 640 Luo elders (60+) in western Kenya, where high HIV prevalence among younger-to-middle aged adults has led to a heavy burden of orphan care. Perceived stress levels were measured using the Luo Perceived Stress Scale (LPSS). Salivary cortisol and casual blood pressure were used as biomarkers of stress. Results were analyzed using random mixed effects models. Overall this study showed that caregivers have higher levels of perceived stress than non-caregivers. For women, household composition, including the number of orphans and adults in the homestead impacted perceived stress. Among men, those who perceived caregiving as burdensome had higher perceived stress. Despite the association between caregiving and perceived stress, there was a minimal relationship between caregiving and the two biomarkers of stress. This may be because caregiving is superimposed onto other stressors and therefore has a minimal physiological impact. These results highlight the importance of local context in determining the impact of the caregiving role on older adult well-being. Copyright © 2012 Elsevier Ltd. All rights reserved.

Residual stresses in high temperature corrosion of pure zirconium using elasto-viscoplastic model: Application to the deflection test in monofacial oxidation

Science.gov (United States)

Fettré, D.; Bouvier, S.; Favergeon, J.; Kurpaska, L.

2015-12-01

The paper is devoted to modeling residual stresses and strains in an oxide film formed during high temperature oxidation. It describes the deflection test in isothermal high-temperature monofacial oxidation (DTMO) of pure zirconium. The model incorporates kinetics and mechanism of oxidation and takes into account elastic, viscoplastic, growth and chemical strains. Different growth strains models are considered, namely, isotropic growth strains given by Pilling-Bedworth ratio, anisotropic growth strains defined by Parise and co-authors and physically based model for growth strain proposed by Clarke. Creep mechanisms based on dislocation slip and core diffusion, are used. A mechanism responsible for through thickness normal stress gradient in the oxide film is proposed. The material parameters are identified using deflection tests under 400 °C, 500 °C and 600 °C. The effect of temperature on creep and stress relaxation is analyzed. Numerical sensitivity study of the DTMO experiment is proposed in order to investigate the effects of the initial foil thickness and platinum coating on the deflection curves.

Quantitative stress measurement of elastic deformation using mechanoluminescent sensor: An intensity ratio model

Science.gov (United States)

Cai, Tao; Guo, Songtao; Li, Yongzeng; Peng, Di; Zhao, Xiaofeng; Liu, Yingzheng

2018-04-01

The mechanoluminescent (ML) sensor is a newly developed non-invasive technique for stress/strain measurement. However, its application has been mostly restricted to qualitative measurement due to the lack of a well-defined relationship between ML intensity and stress. To achieve accurate stress measurement, an intensity ratio model was proposed in this study to establish a quantitative relationship between the stress condition and its ML intensity in elastic deformation. To verify the proposed model, experiments were carried out on a ML measurement system using resin samples mixed with the sensor material SrAl2O4:Eu2+, Dy3+. The ML intensity ratio was found to be dependent on the applied stress and strain rate, and the relationship acquired from the experimental results agreed well with the proposed model. The current study provided a physical explanation for the relationship between ML intensity and its stress condition. The proposed model was applicable in various SrAl2O4:Eu2+, Dy3+-based ML measurement in elastic deformation, and could provide a useful reference for quantitative stress measurement using the ML sensor in general.

Color Shift Modeling of Light-Emitting Diode Lamps in Step-Loaded Stress Testing

OpenAIRE

Cai, Miao; Yang, Daoguo; Huang, J.; Zhang, Maofen; Chen, Xianping; Liang, Caihang; Koh, S.W.; Zhang, G.Q.

2017-01-01

The color coordinate shift of light-emitting diode (LED) lamps is investigated by running three stress-loaded testing methods, namely step-up stress accelerated degradation testing, step-down stress accelerated degradation testing, and constant stress accelerated degradation testing. A power model is proposed as the statistical model of the color shift (CS) process of LED products. Consequently, a CS mechanism constant is obtained for detecting the consistency of CS mechanisms among various s...

Model for Stress-induced Protein Degradation in Lemna minor1

Science.gov (United States)

Cooke, Robert J.; Roberts, Keith; Davies, David D.

1980-01-01

Transfer of Lemna minor fronds to adverse or stress conditions produces a large increase in the rate of protein degradation. Cycloheximide partially inhibits stress-induced protein degradation and also partially inhibits the protein degradation which occurs in the absence of stress. The increased protein degradation does not appear to be due to an increase in activity of soluble proteolytic enzymes. Biochemical evidence indicates that stress, perhaps acting via hormones, affects the permeability of certain membranes, particularly the tonoplast. A general model for stress-induced protein degradation is presented in which changes in membrane properties allow vacuolar proteolytic enzymes increased access to cytoplasmic proteins. PMID:16661588

Mathematical Modeling in Systems for Operational Evaluation of the Stress-Strain State of the Arch-Gravity Dam at the Sayano-Shushenskaya Hydroelectric Power Plant

Energy Technology Data Exchange (ETDEWEB)

Bellendir, E. N.; Gordon, L. A., E-mail: lev-gordon@mail.ru; Khrapkov, A. A.; Skvortsova, A. E., E-mail: SkvortsovaAE@vniig.ru [B. E. Vedeneev All-Russia Research Institute of Hydraulic Engineering (VNIIG) (Russian Federation)

2017-01-15

Current studies of the stress-strain state of the dam at the Sayano-Shushenskaya Hydroelectric Power Plant at VNIIG based on mathematical modeling including full scale and experimental data are described. Applications and programs intended for automatic operational evaluation of the stress-strain state of the dam for optimizing control of the upper race level in the course of the annual filling-drawdown cycle and during seismic events are examined. Improvements in systems for monitoring the stress-strain state of concrete dams are proposed.

Review of reactive kinetic models describing reductive dechlorination of chlorinated ethenes in soil and groundwater

DEFF Research Database (Denmark)

Chambon, Julie Claire Claudia; Bjerg, Poul Løgstrup; Scheutz, Charlotte

2013-01-01

Reductive dechlorination is a major degradation pathway of chlorinated ethenes in anaerobic subsurface environments, and reactive kinetic models describing the degradation process are needed in fate and transport models of these contaminants. However, reductive dechlorination is a complex biologi...

Development of Novel Models for Describing Multiple Toxicity Effects

Science.gov (United States)

1994-10-12

Cimetidine and Thiopropazate Hydrochloride in the Prevention of Stress Ulcer Formation in Rats The Journal of Pharmacology and Experimental Therapeutics , 210...Synergism and Antagonism of GA and Growth Inhibitors on Growth and Sex Expression in Cucumber Journal of the American Society of Horticultural Science...for Synergism and Antagonism The Journal of Pharmacology and Experimental Therapeutics , 259, 1 286-294 (1991). compounds studied: APEC, CHA, NECA

New moment magnitude scale, evidence of stress drop magnitude scaling and stochastic ground motion model for the French West Indies

Science.gov (United States)

Drouet, Stéphane; Bouin, Marie-Paule; Cotton, Fabrice

2011-12-01

In this study we analyse records from the 'Les Saintes' seismic sequence following the Mw= 6.3 earthquake of 2004 November 11, which occurred close to Guadeloupe (French West Indies). 485 earthquakes with magnitudes from 2 to 6, recorded at distances between 5 and 150 km are used. S-waves Fourier spectra are analysed to simultaneously determine source, path and site terms. The results show that the duration magnitude routinely estimated for the events that occurred in the region underestimate moment magnitude by 0.5 magnitude units over the whole magnitude range. From the inverted seismic moments and corner frequencies, we compute Brune's stress drops. We show that stress drops increase with increasing magnitude. The same pattern is observed on apparent stresses (i.e. the seismic energy-to-moment ratio). However, the rate of increase diminishes at high magnitudes, which is consistent with a constant stress drop model for large events. Using the results of the inversions, we perform ground motion simulations for the entire data set using the SMSIM stochastic simulation tool. The results show that a good fit (σ= 0.25) with observed data is achieved when the source is properly described by its moment magnitude and stress drop, and when site effects are taken into account. Although the magnitude-dependent stress drop model is giving better results than the constant stress drop model, the interevent variability remains high, which could suggest that stress drop depends on other parameters such as the depth of the hypocentre. In any case, the overall variability is of the same order of magnitude as usually observed in empirical ground motion prediction equations.

Stress Erythropoiesis Model Systems.

Science.gov (United States)

Bennett, Laura F; Liao, Chang; Paulson, Robert F

2018-01-01

Bone marrow steady-state erythropoiesis maintains erythroid homeostasis throughout life. This process constantly generates new erythrocytes to replace the senescent erythrocytes that are removed by macrophages in the spleen. In contrast, anemic or hypoxic stress induces a physiological response designed to increase oxygen delivery to the tissues. Stress erythropoiesis is a key component of this response. It is best understood in mice where it is extramedullary occurring in the adult spleen and liver and in the fetal liver during development. Stress erythropoiesis utilizes progenitor cells and signals that are distinct from bone marrow steady-state erythropoiesis. Because of that observation many genes may play a role in stress erythropoiesis despite having no effect on steady-state erythropoiesis. In this chapter, we will discuss in vivo and in vitro techniques to study stress erythropoiesis in mice and how the in vitro culture system can be extended to study human stress erythropoiesis.

Animal models for posttraumatic stress disorder: An overview of what is used in research.

Science.gov (United States)

Borghans, Bart; Homberg, Judith R

2015-12-22

Posttraumatic stress disorder (PTSD) is a common anxiety disorder characterised by its persistence of symptoms after a traumatic experience. Although some patients can be cured, many do not benefit enough from the psychological therapies or medication strategies used. Many researchers use animal models to learn more about the disorder and several models are available. The most-used physical stressor models are single-prolonged stress, restraint stress, foot shock, stress-enhanced fear learning, and underwater trauma. Common social stressors are housing instability, social instability, early-life stress, and social defeat. Psychological models are not as diverse and rely on controlled exposure to the test animal's natural predator. While validation of these models has been resolved with replicated symptoms using analogous stressors, translating new findings to human patients remains essential for their impact on the field. Choosing a model to experiment with can be challenging; this overview of what is possible with individual models may aid in making a decision.

Stressful life transitions and wellbeing: A comparison of the stress buffering hypothesis and the social identity model of identity change.

Science.gov (United States)

Praharso, Nurul F; Tear, Morgan J; Cruwys, Tegan

2017-01-01

The relationship between stressful life transitions and wellbeing is well established, however, the protective role of social connectedness has received mixed support. We test two theoretical models, the Stress Buffering Hypothesis and the Social Identity Model of Identity Change, to determine which best explains the relationship between social connectedness, stress, and wellbeing. Study 1 (N=165) was an experiment in which participants considered the impact of moving cities versus receiving a serious health diagnosis. Study 2 (N=79) was a longitudinal study that examined the adjustment of international students to university over the course of their first semester. Both studies found limited evidence for the buffering role of social support as predicted by the Stress Buffering Hypothesis; instead people who experienced a loss of social identities as a result of a stressor had a subsequent decline in wellbeing, consistent with the Social Identity Model of Identity Change. We conclude that stressful life events are best conceptualised as identity transitions. Such events are more likely to be perceived as stressful and compromise wellbeing when they entail identity loss. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

A Discrete Fracture Network Model with Stress-Driven Nucleation and Growth

Science.gov (United States)

Lavoine, E.; Darcel, C.; Munier, R.; Davy, P.

2017-12-01

The realism of Discrete Fracture Network (DFN) models, beyond the bulk statistical properties, relies on the spatial organization of fractures, which is not issued by purely stochastic DFN models. The realism can be improved by injecting prior information in DFN from a better knowledge of the geological fracturing processes. We first develop a model using simple kinematic rules for mimicking the growth of fractures from nucleation to arrest, in order to evaluate the consequences of the DFN structure on the network connectivity and flow properties. The model generates fracture networks with power-law scaling distributions and a percentage of T-intersections that are consistent with field observations. Nevertheless, a larger complexity relying on the spatial variability of natural fractures positions cannot be explained by the random nucleation process. We propose to introduce a stress-driven nucleation in the timewise process of this kinematic model to study the correlations between nucleation, growth and existing fracture patterns. The method uses the stress field generated by existing fractures and remote stress as an input for a Monte-Carlo sampling of nuclei centers at each time step. Networks so generated are found to have correlations over a large range of scales, with a correlation dimension that varies with time and with the function that relates the nucleation probability to stress. A sensibility analysis of input parameters has been performed in 3D to quantify the influence of fractures and remote stress field orientations.

Strategy for a Rock Mechanics Site Descriptive Model. Development and testing of an approach to modelling the state of stress

Energy Technology Data Exchange (ETDEWEB)

Hakami, Eva; Hakami, Hossein [Itasca Geomekanik AB, Solna (Sweden); Cosgrove, John [Imperial College of Science and Technology, London (United Kingdom)

2002-05-01

The overall objective of this project has been to develop, test and establish a method for creating a Rock Mechanics Site Descriptive Model for a site considered in the site investigation programme. The work was divided into three parts, the empirical and theoretical 'property models' and the 'stress model'. The work on the stress model is presented in this report. The work consisted of i) a literature review about geological factors controlling in situ stress and a review about the use of numerical models for this subject, ii) the development of recommendations on the methodology to be applied during a site investigation and iii) the Test Case exercise, where the suggested methods were tested. The main mechanism controlling the in situ stress magnitudes in Sweden is plate tectonics causing the stress field to show similarities in most parts of north-western Europe, having a NW-SE trend of the maximum principal stress. The orientation of the stress field is largely determined by the relative movements by the plates. However, the stress orientation may also be influenced by the presence of large regional weak zones, such as the Tornquist deformation zone that lies between Sweden and Denmark. The strike of the Tornquist deformation zone is parallel to the maximum principal stress as observed in central and southern Sweden. The magnitude of the stress is more difficult to estimate, but the general pattern is an increase in magnitude with depth, at least for the upper kilometres. To determine the stress magnitude at a certain site and depth, with reasonable certainty, stress measurement should be used. A methodology for building a stress model has been proposed. It involves different steps starting with a preliminary stress estimation, followed by steps for interpreting site-specific information. If the stress pattern and structural geology of the site are complex, including major fracture zones intersecting the area, numerical analyses of the

Strategy for a Rock Mechanics Site Descriptive Model. Development and testing of an approach to modelling the state of stress

International Nuclear Information System (INIS)

Hakami, Eva; Hakami, Hossein; Cosgrove, John

2002-05-01

The overall objective of this project has been to develop, test and establish a method for creating a Rock Mechanics Site Descriptive Model for a site considered in the site investigation programme. The work was divided into three parts, the empirical and theoretical 'property models' and the 'stress model'. The work on the stress model is presented in this report. The work consisted of i) a literature review about geological factors controlling in situ stress and a review about the use of numerical models for this subject, ii) the development of recommendations on the methodology to be applied during a site investigation and iii) the Test Case exercise, where the suggested methods were tested. The main mechanism controlling the in situ stress magnitudes in Sweden is plate tectonics causing the stress field to show similarities in most parts of north-western Europe, having a NW-SE trend of the maximum principal stress. The orientation of the stress field is largely determined by the relative movements by the plates. However, the stress orientation may also be influenced by the presence of large regional weak zones, such as the Tornquist deformation zone that lies between Sweden and Denmark. The strike of the Tornquist deformation zone is parallel to the maximum principal stress as observed in central and southern Sweden. The magnitude of the stress is more difficult to estimate, but the general pattern is an increase in magnitude with depth, at least for the upper kilometres. To determine the stress magnitude at a certain site and depth, with reasonable certainty, stress measurement should be used. A methodology for building a stress model has been proposed. It involves different steps starting with a preliminary stress estimation, followed by steps for interpreting site-specific information. If the stress pattern and structural geology of the site are complex, including major fracture zones intersecting the area, numerical analyses of the stress field is

Describing Earth system simulations with the Metafor CIM

Directory of Open Access Journals (Sweden)

B. N. Lawrence

2012-11-01

Full Text Available The Metafor project has developed a common information model (CIM using the ISO19100 series formalism to describe numerical experiments carried out by the Earth system modelling community, the models they use, and the simulations that result. Here we describe the mechanism by which the CIM was developed, and its key properties. We introduce the conceptual and application versions and the controlled vocabularies developed in the context of supporting the fifth Coupled Model Intercomparison Project (CMIP5. We describe how the CIM has been used in experiments to describe model coupling properties and describe the near term expected evolution of the CIM.

Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications

Science.gov (United States)

Pohl, Calvin S.; Medland, Julia E.

2015-01-01

Early-life stress and adversity are major risk factors in the onset and severity of gastrointestinal (GI) disease in humans later in life. The mechanisms by which early-life stress leads to increased GI disease susceptibility in adult life remain poorly understood. Animal models of early-life stress have provided a foundation from which to gain a more fundamental understanding of this important GI disease paradigm. This review focuses on animal models of early-life stress-induced GI disease, with a specific emphasis on translational aspects of each model to specific human GI disease states. Early postnatal development of major GI systems and the consequences of stress on their development are discussed in detail. Relevant translational differences between species and models are highlighted. PMID:26451004

The Structural Model of Spirituality and Psychological Well-Being for Pregnancy-Specific Stress.

Science.gov (United States)

Dolatian, Mahrokh; Mahmoodi, Zohreh; Dilgony, Taibeh; Shams, Jamal; Zaeri, Farid

2017-12-01

Women experience different types of stress in their lifetime. The present study was conducted to examine the structural model of spirituality and psychological well-being for pregnancy-specific stress. The present descriptive correlational study was conducted on 450 pregnant Iranian women (150 women from each trimester) in Dehdasht city in 2015. Data were collected using the personal-social questionnaire, the pregnancy-specific stress questionnaire, the spirituality questionnaire and the psychological well-being questionnaire and were then analyzed in SPSS-16 and Lisrel-8.8 for carrying out a path analysis. The fit indices of the model indicate the good fit and high compatibility of the model and rational relationships between the variables (GFI = 0.94, NFI = 0.85, CFI = 0.94 and RMSEA = 0.048). Of the variables that affected pregnancy-specific stress through both paths, spirituality had a positive effect (B = 0.11) and the personal-social variable a negative effect (B = -0.37). Psychological well-being affected pregnancy-specific stress negatively and directly and through one path only (B = -0.59). The results obtained through the model confirm the effect of spirituality and psychological well-being in reducing pregnancy-specific stress. Given that handling stress has a major role in the quality of daily life in pregnant women, stress management skills are recommended to be promoted among pregnant women so as to mitigate stress and its negative consequences.

Stress and resilience in functional somatic syndromes--a structural equation modeling approach.

Directory of Open Access Journals (Sweden)

Susanne Fischer

Full Text Available BACKGROUND: Stress has been suggested to play a role in the development and perpetuation of functional somatic syndromes. The mechanisms of how this might occur are not clear. PURPOSE: We propose a multi-dimensional stress model which posits that childhood trauma increases adult stress reactivity (i.e., an individual's tendency to respond strongly to stressors and reduces resilience (e.g., the belief in one's competence. This in turn facilitates the manifestation of functional somatic syndromes via chronic stress. We tested this model cross-sectionally and prospectively. METHODS: Young adults participated in a web survey at two time points. Structural equation modeling was used to test our model. The final sample consisted of 3'054 participants, and 429 of these participated in the follow-up survey. RESULTS: Our proposed model fit the data in the cross-sectional (χ2(21  = 48.808, p<.001, CFI  = .995, TLI  = .992, RMSEA  = .021, 90% CI [.013.029] and prospective analyses (χ2(21  =  32.675, p<.05, CFI  = .982, TLI  = .969, RMSEA  = .036, 90% CI [.001.059]. DISCUSSION: Our findings have several clinical implications, suggesting a role for stress management training in the prevention and treatment of functional somatic syndromes.

Extending the bounds of ‘steady’ RANS closures: Toward an instability-sensitive Reynolds stress model

International Nuclear Information System (INIS)

Jakirlić, S.; Maduta, R.

2015-01-01

Highlights: • A grid-spacing free, instability-sensitive Reynolds stress model is formulated. • The model is capable of capturing turbulence fluctuations. • Substantial improvement concerning proper turbulence activity enhancement is achieved. • The model is intensively validated in a series of 2D and 3D separating flows. • The model feasibility is also checked in some attached flows. - Abstract: The incapability of the conventional Unsteady RANS (Reynolds–Averaged Navier Stokes) models to adequately capture turbulence unsteadiness presents the prime motivation of the present work, which focuses on formulating an instability-sensitive, eddy-resolving turbulence model on the Second-Moment Closure level. The model scheme adopted, functioning as a ‘sub-scale’ model in the Unsteady RANS framework, represents a differential near-wall Reynolds stress model formulated in conjunction with the scale-supplying equation governing the homogeneous part of the inverse turbulent time scale ω h (ω h = ε h /k). The latter equation was straightforwardly obtained from the model equation describing the dynamics of the homogeneous part of the total viscous dissipation rate ε, defined as ε h = ε − 0.5ν∂ 2 k/(∂x j ∂x j ) (Jakirlic and Hanjalic, 2002), by applying the derivation rules to the expression for ω h . The model capability to account for vortex length and time scales variability was enabled through an additional term in the corresponding length-scale determining equation, providing a selective enhancement of its production, pertinent particularly to the highly unsteady separated shear layer region, modeled in terms of the von Karman length scale (comprising the second derivative of the velocity field) in line with the SAS (Scale-Adaptive Simulation) proposal (Menter and Egorov, 2010). The present model formulation, termed as SRANS model (Sensitized RANS), does not comprise any parameter depending explicitly on grid spacing. The predictive

Modeling of stress-strain diagram on the basis of magnetic measurements

International Nuclear Information System (INIS)

Gorkunov, Eh.S.; Fedotov, V.P.; Bukhvalov, A.B.; Veselov, I.N.

1997-01-01

The model of a stress-strain diagram with taking into account the strain hardening and the growth of metal damageing is proposed. The model is applied to calculate a stress-strain curve for continuous cast 45 steel using the results of magnetic properties measuring. The latter permits predicting the durability of construction elements with the use of nondestructive magnetic testing

PWSCC Growth Assessment Model Considering Stress Triaxiality Factor for Primary Alloy 600 Components

Directory of Open Access Journals (Sweden)

Jong-Sung Kim

2016-08-01

Full Text Available We propose a primary water stress corrosion cracking (PWSCC initiation model of Alloy 600 that considers the stress triaxiality factor to apply to finite element analysis. We investigated the correlation between stress triaxiality effects and PWSCC growth behavior in cold-worked Alloy 600 stream generator tubes, and identified an additional stress triaxiality factor that can be added to Garud's PWSCC initiation model. By applying the proposed PWSCC initiation model considering the stress triaxiality factor, PWSCC growth simulations based on the macroscopic phenomenological damage mechanics approach were carried out on the PWSCC growth tests of various cold-worked Alloy 600 steam generator tubes and compact tension specimens. As a result, PWSCC growth behavior results from the finite element prediction are in good agreement with the experimental results.

Field measurements, simulation modeling and development of analysis for moisture stressed corn and soybeans, 1982 studies

Science.gov (United States)

Blad, B. L.; Norman, J. M.; Gardner, B. R.

1983-01-01

The experimental design, data acquisition and analysis procedures for agronomic and reflectance data acquired over corn and soybeans at the Sandhills Agricultural Laboratory of the University of Nebraska are described. The following conclusions were reached: (1) predictive leaf area estimation models can be defined which appear valid over a wide range of soils; (2) relative grain yield estimates over moisture stressed corn were improved by combining reflectance and thermal data; (3) corn phenology estimates using the model of Badhwar and Henderson (1981) exhibited systematic bias but were reasonably accurate; (4) canopy reflectance can be modelled to within approximately 10% of measured values; and (5) soybean pubescence significantly affects canopy reflectance, energy balance and water use relationships.

REGULAR AND SPECIFIC FEATURES OF STRESSED AND DEFORMED STATE OF COMPOSITE MATERIAL WITH PIERCED OPENING

Directory of Open Access Journals (Sweden)

Yu. V. Vasilevich

2007-01-01

Full Text Available Mathematical model describing a dependence between deformations and stresses in the zone of prepreg piercing zone is given in the paper. Boundary conditions in the piercing zone in number of four functional dependences for prepregs can express either the given stresses or displacements, or describe boundary form, or express relations between stresses and displacements etc.

Stress modeling of microdiaphragm pressure sensors

Science.gov (United States)

Tack, P. C.; Busta, H. H.

1986-01-01

A finite element program analysis was used to model the stress distribution of two monocrystalline silicon diaphragm pressure sensors. One configuration consists of an anisotropically backside etched diaphragm into a 250 micron thick, (100) oriented, silicon wafer. The diaphragm and total chip dimensions are given. The device is rigidly clamped on the back to a support substrate. Another configuration consists of a monocrystalline, (100), microdiaphragm which is formed on top of the wafer and whose area is reduced by a factor of 25 over the first configuration. The diaphragm is rigidly clamped to the silicon wafer. The stresses were calculated at a gauge pressure of 300 mm Hg and used to estimate the piezoresistive responses of resistor elements which were placed parallel and perpendicular near the diaphragm edges.

A fractional model with parallel fractional Maxwell elements for amorphous thermoplastics

Science.gov (United States)

Lei, Dong; Liang, Yingjie; Xiao, Rui

2018-01-01

We develop a fractional model to describe the thermomechanical behavior of amorphous thermoplastics. The fractional model is composed of two parallel fractional Maxwell elements. The first fractional Maxwell model is used to describe the glass transition, while the second component is aimed at describing the viscous flow. We further derive the analytical solutions for the stress relaxation modulus and complex modulus through Laplace transform. We then demonstrate the model is able to describe the master curves of the stress relaxation modulus, storage modulus and loss modulus, which all show two distinct transition regions. The obtained parameters show that the modulus of the two fractional Maxwell elements differs in 2-3 orders of magnitude, while the relaxation time differs in 7-9 orders of magnitude. Finally, we apply the model to describe the stress response of constant strain rate tests. The model, together with the parameters obtained from fitting the master curve of stress relaxation modulus, can accurately predict the temperature and strain rate dependent stress response.

A thermodynamical model for stress-fiber organization in contractile cells.

Science.gov (United States)

Foucard, Louis; Vernerey, Franck J

2012-01-02

Cell mechanical adaptivity to external stimuli is vital to many of its biological functions. A critical question is therefore to understand the formation and organization of the stress fibers from which emerge the cell's mechanical properties. By accounting for the mechanical aspects and the viscoelastic behavior of stress fibers, we here propose a thermodynamic model to predict the formation and orientation of stress fibers in contractile cells subjected to constant or cyclic stretch and different substrate stiffness. Our results demonstrate that the stress fibers viscoelastic behavior plays a crucial role in their formation and organization and shows good consistency with various experiments.

THE TECTONICS STRESS AND STRAIN FIELD MODELING ADJUSTED FOR EVOLUTION OF GEOLOGICAL STRUCTURES (SAILAG INTRUSION, EASTERN SAYAN

Directory of Open Access Journals (Sweden)

V. N. Voytenko

2013-01-01

Full Text Available The article describes a tectonophysical model showing evolution of structures in the Sailag granodiorite massif in relation to its gold-bearing capacity. The model takes into account the load patterns according to geological data, accumulated deformation, and gravity stresses. This model provides for updating the structural-geological model showing development of the intrusion body and the ore field. Forecasted are destruction patterns in the apical and above-dome parts of the massif  in the intrusion and contraction phase, formation of the long-term shear zone at the steeply dipping slope of the intrusion body, and subvertical fractures associated with the long-term shear zone and vertical mechanical ‘layering’ of the intrusive body.  

Modeling Phytoremediation of Cadmium Contaminated Soil with Sunflower (Helianthus annus) Under Salinity Stress

International Nuclear Information System (INIS)

Motesharezadeh, B.; Navabzadeh, M.; Liyaghat, A. M.

2016-01-01

This study was carried out as a factorial experiment with 5 levels of cadmium (Cd) (o, 25, 50, 75, and 100 mg/kg), 5 levels of salinity (Control, 4, 5, 6, and 7 dS/m), and two soil textures (sandy loam and clay loam). The results showed that the amount of Cd in root and shoot of sunflower increased as soil salinity and Cd concentration increased. The best concentrations for Cd phytoremediation were 75 mg/kg in sandy loam and 100 mg/kg in clay loam. Mass-Hoffman model in simulating transpiration Cd stress as well as Homaee model in simulating salt stress indicated the best results in light soils. By multiplying the salinity stress model by Cd stress model, the simultaneous model for each soil was calculated. These models in light soil (r2=0.68) and heavy soil (r2=0.81) were compatible with measured values. In the heavy soil, absorbed Cd by plant along with increased salinity reflected low changes, but changes in Cd absorbed by plants in the heavy soil were more uniform than in the light soil. In conclusion, for estimating the Cd uptake, the model had a better performance in the heavy soil (under salt stress).

The potential of epigenetics in stress-enhanced fear learning models of PTSD.

Science.gov (United States)

Blouin, Ashley M; Sillivan, Stephanie E; Joseph, Nadine F; Miller, Courtney A

2016-10-01

Prolonged distress and dysregulated memory processes are the core features of post-traumatic stress disorder (PTSD) and represent the debilitating, persistent nature of the illness. However, the neurobiological mechanisms underlying the expression of these symptoms are challenging to study in human patients. Stress-enhanced fear learning (SEFL) paradigms, which encompass both stress and memory components in rodents, are emerging as valuable preclinical models of PTSD. Rodent models designed to study the long-term mechanisms of either stress or fear memory alone have identified a critical role for numerous epigenetic modifications to DNA and histone proteins. However, the epigenetic modifications underlying SEFL remain largely unknown. This review will provide a brief overview of the epigenetic modifications implicated in stress and fear memory independently, followed by a description of existing SEFL models and the few epigenetic mechanisms found to date to underlie SEFL. The results of the animal studies discussed here highlight neuroepigenetics as an essential area for future research in the context of PTSD through SEFL studies, because of its potential to identify novel candidates for neurotherapeutics targeting stress-induced pathogenic memories. © 2016 Blouin et al.; Published by Cold Spring Harbor Laboratory Press.

Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications.

Science.gov (United States)

Pohl, Calvin S; Medland, Julia E; Moeser, Adam J

2015-12-15

Early-life stress and adversity are major risk factors in the onset and severity of gastrointestinal (GI) disease in humans later in life. The mechanisms by which early-life stress leads to increased GI disease susceptibility in adult life remain poorly understood. Animal models of early-life stress have provided a foundation from which to gain a more fundamental understanding of this important GI disease paradigm. This review focuses on animal models of early-life stress-induced GI disease, with a specific emphasis on translational aspects of each model to specific human GI disease states. Early postnatal development of major GI systems and the consequences of stress on their development are discussed in detail. Relevant translational differences between species and models are highlighted. Copyright © 2015 the American Physiological Society.

Inhomogeneous Markov Models for Describing Driving Patterns

DEFF Research Database (Denmark)

Iversen, Emil Banning; Møller, Jan K.; Morales, Juan Miguel

2017-01-01

. Specifically, an inhomogeneous Markov model that captures the diurnal variation in the use of a vehicle is presented. The model is defined by the time-varying probabilities of starting and ending a trip, and is justified due to the uncertainty associated with the use of the vehicle. The model is fitted to data...... collected from the actual utilization of a vehicle. Inhomogeneous Markov models imply a large number of parameters. The number of parameters in the proposed model is reduced using B-splines....

Inhomogeneous Markov Models for Describing Driving Patterns

DEFF Research Database (Denmark)

Iversen, Jan Emil Banning; Møller, Jan Kloppenborg; Morales González, Juan Miguel

. Specically, an inhomogeneous Markov model that captures the diurnal variation in the use of a vehicle is presented. The model is dened by the time-varying probabilities of starting and ending a trip and is justied due to the uncertainty associated with the use of the vehicle. The model is tted to data...... collected from the actual utilization of a vehicle. Inhomogeneous Markov models imply a large number of parameters. The number of parameters in the proposed model is reduced using B-splines....

Computational stress and damage modelling for rolling contact fatigue

DEFF Research Database (Denmark)

Cerullo, Michele

Rolling contact fatigue in radial roller bearings is studied by means of a 2D plane strain nite element program. The Dang Van multiaxial fatigue criterion is firstly used, in a macroscopic study modeling the bearing raceway, to investigate the region where fatigue cracks are more likely to nucleate...... and of compressive residual stresses are also analyzed. The stress history of a material point at the depth where the maximum Dang Van damage factor is reached is then recorded and used in a subsequent micro-mechanical analysis. The stress history is applied as periodic boundary conditions in a representative volume...

Testing a cognitive model to predict posttraumatic stress disorder following childbirth.

Science.gov (United States)

King, Lydia; McKenzie-McHarg, Kirstie; Horsch, Antje

2017-01-14

One third of women describes their childbirth as traumatic and between 0.8 and 6.9% goes on to develop posttraumatic stress disorder (PTSD). The cognitive model of PTSD has been shown to be applicable to a range of trauma samples. However, childbirth is qualitatively different to other trauma types and special consideration needs to be taken when applying it to this population. Previous studies have investigated some cognitive variables in isolation but no study has so far looked at all the key processes described in the cognitive model. This study therefore aimed to investigate whether theoretically-derived variables of the cognitive model explain unique variance in postnatal PTSD symptoms when key demographic, obstetric and clinical risk factors are controlled for. One-hundred and fifty-seven women who were between 1 and 12 months post-partum (M = 6.5 months) completed validated questionnaires assessing PTSD and depressive symptoms, childbirth experience, postnatal social support, trauma memory, peritraumatic processing, negative appraisals, dysfunctional cognitive and behavioural strategies and obstetric as well as demographic risk factors in an online survey. A PTSD screening questionnaire suggested that 5.7% of the sample might fulfil diagnostic criteria for PTSD. Overall, risk factors alone predicted 43% of variance in PTSD symptoms and cognitive behavioural factors alone predicted 72.7%. A final model including both risk factors and cognitive behavioural factors explained 73.7% of the variance in PTSD symptoms, 37.1% of which was unique variance predicted by cognitive factors. All variables derived from Ehlers and Clark's cognitive model significantly explained variance in PTSD symptoms following childbirth, even when clinical, demographic and obstetric were controlled for. Our findings suggest that the CBT model is applicable and useful as a way of understanding and informing the treatment of PTSD following childbirth.

A thermodynamical model for stress-fiber organization in contractile cells

OpenAIRE

Foucard, Louis; Vernerey, Franck J.

2012-01-01

Cell mechanical adaptivity to external stimuli is vital to many of its biological functions. A critical question is therefore to understand the formation and organization of the stress fibers from which emerge the cell’s mechanical properties. By accounting for the mechanical aspects and the viscoelastic behavior of stress fibers, we here propose a thermodynamic model to predict the formation and orientation of stress fibers in contractile cells subjected to constant or cyclic stretch and dif...

ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta.

Directory of Open Access Journals (Sweden)

Thomas S Lisse

2008-02-01

Full Text Available Osteogenesis imperfecta is an inherited disorder characterized by increased bone fragility, fractures, and osteoporosis, and most cases are caused by mutations affecting the type I collagen genes. Here, we describe a new mouse model for Osteogenesis imperfecta termed Aga2 (abnormal gait 2 that was isolated from the Munich N-ethyl-N-nitrosourea mutagenesis program and exhibited phenotypic variability, including reduced bone mass, multiple fractures, and early lethality. The causal gene was mapped to Chromosome 11 by linkage analysis, and a C-terminal frameshift mutation was identified in the Col1a1 (procollagen type I, alpha 1 gene as the cause of the disorder. Aga2 heterozygous animals had markedly increased bone turnover and a disrupted native collagen network. Further studies showed that abnormal proalpha1(I chains accumulated intracellularly in Aga2/+ dermal fibroblasts and were poorly secreted extracellularly. This was associated with the induction of an endoplasmic reticulum stress-specific unfolded protein response involving upregulation of BiP, Hsp47, and Gadd153 with caspases-12 and -3 activation and apoptosis of osteoblasts both in vitro and in vivo. These studies resulted in the identification of a new model for Osteogenesis imperfecta, and identified a role for intracellular modulation of the endoplasmic reticulum stress-associated unfolded protein response machinery toward osteoblast apoptosis during the pathogenesis of disease.

A Test of the Family Stress Model on Toddler-Aged Children's Adjustment among Hurricane Katrina Impacted and Nonimpacted Low-Income Families

Science.gov (United States)

Scaramella, Laura V.; Sohr-Preston, Sara L.; Callahan, Kristin L.; Mirabile, Scott P.

2008-01-01

Hurricane Katrina dramatically altered the level of social and environmental stressors for the residents of the New Orleans area. The Family Stress Model describes a process whereby felt financial strain undermines parents' mental health, the quality of family relationships, and child adjustment. Our study considered the extent to which the Family…

Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model.

Science.gov (United States)

Kohda, K; Harada, K; Kato, K; Hoshino, A; Motohashi, J; Yamaji, T; Morinobu, S; Matsuoka, N; Kato, N

2007-08-10

Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience, and presents with characteristic symptoms, such as intrusive memories, a state of hyperarousal, and avoidance, that endure for years. Single-prolonged stress (SPS) is one of the animal models proposed for PTSD. Rats exposed to SPS showed enhanced inhibition of the hypothalamo-pituitary-adrenal (HPA) axis, which has been reliably reproduced in patients with PTSD, and increased expression of glucocorticoid receptor (GR) in the hippocampus. In this study, we characterized further neuroendocrinologic, behavioral and electrophysiological alterations in SPS rats. Plasma corticosterone recovered from an initial increase within a week, and gross histological changes and neuronal cell death were not observed in the hippocampus of the SPS rats. Behavioral analyses revealed that the SPS rats presented enhanced acoustic startle and impaired spatial memory that paralleled the deficits in hippocampal long-term potentiation (LTP) and depression. Contextual fear memory was enhanced in the rats 1 week after SPS exposure, whereas LTP in the amygdala was blunted. Interestingly, blockade of GR activation by administering 17-beta-hydroxy-11-beta-/4-/[methyl]-[1-methylethyl]aminophenyl/-17-alpha-[prop-1-ynyl]estra-4-9-diene-3-one (RU40555), a GR antagonist, prior to SPS exposure prevented potentiation of fear conditioning and impairment of LTP in the CA1 region. Altogether, SPS caused a number of behavioral changes similar to those described in PTSD, which marks SPS as a putative PTSD model. The preventive effects of a GR antagonist suggested that GR activation might play a critical role in producing the altered behavior and neuronal function of SPS rats.

Muscle activation described with a differential equation model for large ensembles of locally coupled molecular motors.

Science.gov (United States)

Walcott, Sam

2014-10-01

Molecular motors, by turning chemical energy into mechanical work, are responsible for active cellular processes. Often groups of these motors work together to perform their biological role. Motors in an ensemble are coupled and exhibit complex emergent behavior. Although large motor ensembles can be modeled with partial differential equations (PDEs) by assuming that molecules function independently of their neighbors, this assumption is violated when motors are coupled locally. It is therefore unclear how to describe the ensemble behavior of the locally coupled motors responsible for biological processes such as calcium-dependent skeletal muscle activation. Here we develop a theory to describe locally coupled motor ensembles and apply the theory to skeletal muscle activation. The central idea is that a muscle filament can be divided into two phases: an active and an inactive phase. Dynamic changes in the relative size of these phases are described by a set of linear ordinary differential equations (ODEs). As the dynamics of the active phase are described by PDEs, muscle activation is governed by a set of coupled ODEs and PDEs, building on previous PDE models. With comparison to Monte Carlo simulations, we demonstrate that the theory captures the behavior of locally coupled ensembles. The theory also plausibly describes and predicts muscle experiments from molecular to whole muscle scales, suggesting that a micro- to macroscale muscle model is within reach.

Application of magnetomechanical hysteresis modeling of magnetic techniques for monitoring neutron embrittlement and biaxial stress

International Nuclear Information System (INIS)

Sablik, M.J.; Kwun, H.; Burkhardt, G.L.

1993-01-01

Research was done on the biaxial stress problem accomplished in the first half of the second year. All of the work done was preparatory to magnetic measurements. Issues addressed were: construction of a model for extracting changes in the magnetic properties of a specimen from the readings of an indirect sensor; initial development of a model for how biaxial stress alters the intrinsic magnetic properties of thespecimen; use of finite element stress analysis modeling to determine a detailed shape for the cruciform biaxial stress specimen; and construction of the biaxial stress loading apparatus

Development of a model describing virus removal process in an activated sludge basin

Energy Technology Data Exchange (ETDEWEB)

Kim, T.; Shiragami, N. Unno, H. [Tokyo Institute of Technology, Tokyo (Japan)

1995-06-20

The virus removal process from the liquid phase in an activated sludge basin possibly consists of physicochemical processes, such as adsorption onto sludge flocs, biological processes such as microbial predating and inactivation by virucidal components excreted by microbes. To describe properly the virus behavior in an activated sludge basin, a simple model is proposed based on the experimental data obtained using a poliovirus type 1. A three-compartments model, which include the virus in the liquid phase and in the peripheral and inner regions of sludge flocs is employed. By using the model, the Virus removal process was successfully simulated to highlight the implication of its distribution in the activated sludge basin. 17 refs., 8 figs.

On the use of effective stress in three-dimensional hydro-mechanical coupled model

International Nuclear Information System (INIS)

Arairo, W.; Prunier, F.; Djeran-Maigre, I.; Millard, A.

2014-01-01

In the last decades, a number of hydro-mechanical elastoplastic constitutive models for unsaturated soils have been proposed. Those models couple the hydraulic and mechanical behaviour of unsaturated soils, and take into account the effects of the degree of saturation on the stress-strain behaviour and the effects of deformation on the soil-water characteristic response with a simple reversible part for the hysteresis. In addition, the influence of the suction on the stress-strain behaviour is considered. However, until now, few models predict the stress-strain and soil-water characteristic responses of unsaturated soils in a fully three-dimensional Finite Element code. This paper presents the predictions of an unsaturated soil model in a Three-dimensional Framework, and develops a study on the effect of partial saturation on the stability of shallow foundation resting on unsaturated silty soil. Qualitative predictions of the constitutive model show that incorporating a special formulation for the effective stress into an elastoplastic coupled hydro-mechanical model opens a full range of possibilities in modelling unsaturated soil behaviour. (authors)

Abnormal stress responsivity in a rodent developmental disruption model of schizophrenia.

Science.gov (United States)

Zimmerman, Eric C; Bellaire, Mark; Ewing, Samuel G; Grace, Anthony A

2013-10-01

Although numerous studies have implicated stress in the pathophysiology of schizophrenia, less is known about how the effects of stress interact with genetic, developmental, and/or environmental determinants to promote disease progression. In particular, it has been proposed that in humans, stress exposure in adolescence could combine with a predisposition towards increased stress sensitivity, leading to prodromal symptoms and eventually psychosis. However, the neurobiological substrates for this interaction are not fully characterized. Previous work in our lab has demonstrated that rats born to dams administered with the DNA-methylating agent methylazoxymethanol acetate (MAM) at gestational day 17 exhibit as adults behavioral and anatomical abnormalities consistent with those observed in patients with schizophrenia. Here, we examined behavioral and neuroendocrine responses to stress in the MAM model of schizophrenia. MAM-treated male rats were exposed to acute and repeated footshock stress at prepubertal, peripubteral, and adult ages. Ultrasonic vocalizations (USVs), freezing, and corticosterone responses were quantified. We found that juvenile MAM-treated rats emitted significantly more calls, spent more time vocalizing, emitted calls at a higher rate, and showed more freezing in response to acute footshock stress when compared with their saline (SAL) treated counterparts, and that this difference is not present in older animals. In addition, adolescent MAM-treated animals displayed a blunted HPA axis corticosterone response to acute footshock that did not adapt after 10 days of stress exposure. These data demonstrate abnormal stress responsivity in the MAM model of schizophrenia and suggest that these animals are more sensitive to the effects of stress in youth.

New plastic plane stress model for concrete

International Nuclear Information System (INIS)

Winnicki, A.; Cichon, Cz.

1993-01-01

In the paper a description of concrete behaviour in the plane stress case is given on the basis of the modified bounding surface plasticity theory. Three independent plastic mechanisms have been introduced describing axiatoric and deviatoric plastic strains and their coupling. All the new analytical formulae for material functions being in agreement with experiments and loading/unloading criteria have been proposed. In addition, for the proper description of concrete behaviour in tension a new, separate function of bounding surface shrinkage has been introduced. (author)

Creep modeling of textured zircaloy under biaxial stressing

International Nuclear Information System (INIS)

Adams, B.L.; Murty, K.L.

1984-01-01

Anisotropic biaxial creep behavior of textured Zircaloy tubing was modeled using a crystal-plastic uniform strain-rate upper-bound and a uniform stress lower-bound approach. Power-law steady-state creep is considered to occur on each crystallite glide system by fixing the slip rate to be proportional to the resolved shear stress raised to a power. Prismatic, basal, and pyramidal slip modes were considered. The crystallographic texture is characterized using the orientation distribution function determined from a set of three pole-figures. This method is contrasted with a Von-Mises-Hill phenomenological model in comparison with experimental data obtained at 673 deg K. The resulting creep-dissipative loci show the importance of the basal slip mode on creep in heavily cold-worked cladding, whereas prismatic slip is more important for the recrystallized materials. (author)

Behavioral profiling as a translational approach in an animal model of posttraumatic stress disorder.

Science.gov (United States)

Ardi, Ziv; Albrecht, Anne; Richter-Levin, Alon; Saha, Rinki; Richter-Levin, Gal

2016-04-01

Diagnosis of psychiatric disorders in humans is based on comparing individuals to the normal population. However, many animal models analyze averaged group effects, thus compromising their translational power. This discrepancy is particularly relevant in posttraumatic stress disorder (PTSD), where only a minority develop the disorder following a traumatic experience. In our PTSD rat model, we utilize a novel behavioral profiling approach that allows the classification of affected and unaffected individuals in a trauma-exposed population. Rats were exposed to underwater trauma (UWT) and four weeks later their individual performances in the open field and elevated plus maze were compared to those of the control group, allowing the identification of affected and resilient UWT-exposed rats. Behavioral profiling revealed that only a subset of the UWT-exposed rats developed long-lasting behavioral symptoms. The proportion of affected rats was further enhanced by pre-exposure to juvenile stress, a well-described risk factor of PTSD. For a biochemical proof of concept we analyzed the expression levels of the GABAA receptor subunits α1 and α2 in the ventral, dorsal hippocampus and basolateral amygdala. Increased expression, mainly of α1, was observed in ventral but not dorsal hippocampus of exposed animals, which would traditionally be interpreted as being associated with the exposure-resultant psychopathology. However, behavioral profiling revealed that this increased expression was confined to exposed-unaffected individuals, suggesting a resilience-associated expression regulation. The results provide evidence for the importance of employing behavioral profiling in animal models of PTSD, in order to better understand the neural basis of stress vulnerability and resilience. Copyright © 2016 Elsevier Inc. All rights reserved.

Log-layer mismatch and modeling of the fluctuating wall stress in wall-modeled large-eddy simulations

Science.gov (United States)

Yang, Xiang I. A.; Park, George Ilhwan; Moin, Parviz

2017-10-01

Log-layer mismatch refers to a chronic problem found in wall-modeled large-eddy simulation (WMLES) or detached-eddy simulation, where the modeled wall-shear stress deviates from the true one by approximately 15 % . Many efforts have been made to resolve this mismatch. The often-used fixes, which are generally ad hoc, include modifying subgrid-scale stress models, adding a stochastic forcing, and moving the LES-wall-model matching location away from the wall. An analysis motivated by the integral wall-model formalism suggests that log-layer mismatch is resolved by the built-in physics-based temporal filtering. In this work we investigate in detail the effects of local filtering on log-layer mismatch. We show that both local temporal filtering and local wall-parallel filtering resolve log-layer mismatch without moving the LES-wall-model matching location away from the wall. Additionally, we look into the momentum balance in the near-wall region to provide an alternative explanation of how LLM occurs, which does not necessarily rely on the numerical-error argument. While filtering resolves log-layer mismatch, the quality of the wall-shear stress fluctuations predicted by WMLES does not improve with our remedy. The wall-shear stress fluctuations are highly underpredicted due to the implied use of LES filtering. However, good agreement can be found when the WMLES data are compared to the direct numerical simulation data filtered at the corresponding WMLES resolutions.

Job design and job stress in office workers.

Science.gov (United States)

Carayon, P

1993-05-01

A model to look at various job components that affect individual well-being and health was developed drawing from the job design and job stress literature. Briefly stated, the model proposes job control to be a primary causal determinant of the stress outcomes. The effects of perceived demands, job content, and career/future concerns were hypothesized to influence the stress outcomes only to the extent of their influence on job control. This was tested in a population of government office employees in various clerical, professional, and managerial jobs all of which involve the use of computers. Results indicated that job control was not a crucial determinant of the stress outcomes, that job demands and career/future concerns were consistent determinants of the stress outcomes, and that job content, demands, and career/future concerns did not influence the stress outcomes through job control as described by the proposed model. The differentiation of job control levels to define specific relationships with stress outcomes and other job elements was shown to be useful because different levels of job control were associated with different stress outcomes and job elements.

Buoyancy limits on magnetic viscosity stress-law scalings in quasi stellar object accretion disk models

International Nuclear Information System (INIS)

Sakimoto, P.J.

1985-01-01

Quasi-Stellar Objects (QSOs) are apparently the excessively bright nuclei of distant galaxies. They are thought to be powered by accretion disks surrounding supermassive black holes: however, proof of this presumption is hampered by major uncertainties in the viscous stress necessary for accretion to occur. Models generally assume an and hoc stress law which scales the stress with the total pressure. Near the black hole, radiation pressure dominates gas pressure; scaling the stress with the radiation pressure results in disk models that are thermally unstable and optically thin. This dissertation shows that a radiation pressure scaling for the stress is not possible if the viscosity is due to turbulent magnetic Maxwell stresses. The argument is one of internal self-consistency. First, four model accretion disks that bound the reasonably expected ranges of viscous stress scalings and vertical structures are constructed. Magnetic flux tubes of various initial field strengths are then placed within these models, nd their buoyancy is modeled numerically. In disks using the radiation pressure stress law scaling, low opacities allow rapid heat flow into the flux tubes: the tubes are extremely buoyant, and magnetic fields strong enough to provide the required stress cannot be retained. If an alternative gas pressure scaling for the stress is assumed, then the disks are optically thick; flux tubes have corresponding lower buoyancy, and magnetic fields strong enough to provide the stress can be retained for dynamically significant time periods

Systemic oxidative stress markers in animal model for depression

DEFF Research Database (Denmark)

Bouzinova, Elena; Kravtsova, Violetta; Aalkjær, Christian

Involvement of oxidative stress (OxS) in development of major depressive disorder has recently become evident, though mechanisms behind this remain elusive. We analyzed therefore OxS pathways in rat Chronic Mild Stress (CMS) model of depression. Rats are exposed to chronic unpredictable mild...... mg/kg/day). Saline injections were done to control the vehicle effect. Escitalopram treated rats were sub-divided into 2 groups: responders and non-responders, according to their hedonic state and compared to non-stressed rats, treated with either saline or Escitalopram. Measurement of total...... glutathione and malondialdehyde (MDA) in lungs, heart, skeletal muscles, liver, saphenous, mesenteric, and tail arteries were used as estimates for OxS. In heart, glutathione was increased in CMS rats in comparison with non-stressed vehicle group. Accordingly, an estimate for free radical activity, MDA...

Reliability of Coulomb stress changes inferred from correlated uncertainties of finite-fault source models

KAUST Repository

Woessner, J.

2012-07-14

Static stress transfer is one physical mechanism to explain triggered seismicity. Coseismic stress-change calculations strongly depend on the parameterization of the causative finite-fault source model. These models are uncertain due to uncertainties in input data, model assumptions, and modeling procedures. However, fault model uncertainties have usually been ignored in stress-triggering studies and have not been propagated to assess the reliability of Coulomb failure stress change (ΔCFS) calculations. We show how these uncertainties can be used to provide confidence intervals for co-seismic ΔCFS-values. We demonstrate this for the MW = 5.9 June 2000 Kleifarvatn earthquake in southwest Iceland and systematically map these uncertainties. A set of 2500 candidate source models from the full posterior fault-parameter distribution was used to compute 2500 ΔCFS maps. We assess the reliability of the ΔCFS-values from the coefficient of variation (CV) and deem ΔCFS-values to be reliable where they are at least twice as large as the standard deviation (CV ≤ 0.5). Unreliable ΔCFS-values are found near the causative fault and between lobes of positive and negative stress change, where a small change in fault strike causes ΔCFS-values to change sign. The most reliable ΔCFS-values are found away from the source fault in the middle of positive and negative ΔCFS-lobes, a likely general pattern. Using the reliability criterion, our results support the static stress-triggering hypothesis. Nevertheless, our analysis also suggests that results from previous stress-triggering studies not considering source model uncertainties may have lead to a biased interpretation of the importance of static stress-triggering.

An analytical model of the mechanical properties of bulk coal under confined stress

Science.gov (United States)

Wang, G.X.; Wang, Z.T.; Rudolph, V.; Massarotto, P.; Finley, R.J.

2007-01-01

This paper presents the development of an analytical model which can be used to relate the structural parameters of coal to its mechanical properties such as elastic modulus and Poisson's ratio under a confined stress condition. This model is developed primarily to support process modeling of coalbed methane (CBM) or CO2-enhanced CBM (ECBM) recovery from coal seam. It applied an innovative approach by which stresses acting on and strains occurring in coal are successively combined in rectangular coordinates, leading to the aggregated mechanical constants. These mechanical properties represent important information for improving CBM/ECBM simulations and incorporating within these considerations of directional permeability. The model, consisting of constitutive equations which implement a mechanically consistent stress-strains correlation, can be used as a generalized tool to study the mechanical and fluid behaviors of coal composites. An example using the model to predict the stress-strain correlation of coal under triaxial confined stress by accounting for the elastic and brittle (non-elastic) deformations is discussed. The result shows a good agreement between the prediction and the experimental measurement. ?? 2007 Elsevier Ltd. All rights reserved.

THE BASIS OF MATHEMATICAL DESCRIPTION FOR WAVE MODEL OF STRESSES PROPAGATION IN RAILWAY TRACK

Directory of Open Access Journals (Sweden)

D. M. Kurhan

2016-10-01

Full Text Available Purpose. Modern scientific research has repeatedly cited practical examples of the dynamic effects of railway track operation that go beyond the static calculation schemes. For the track sections where the train speed is approaching to the velocity of wave propagation in the slab track layers such issues are of particular relevance. An adequate tool for the study of such issues can be the use of the wave theory of stress propagation. The purpose of the article is the creation of a mathematical description of the basic principles of the stress propagation wave model in the railway track, which can be used as a basis for the practical development of the relevant calculation system. Methodology. The model of stress-strain states of the railway track on the basis of the stress wave propagation theory is to bring together the equations of the geometry of the outline of the space systems that is involved in the interaction at a given time, and the dynamic equilibrium equations of deformation. The solution is based on the use of the laws of the theory of elasticity. The wave front is described by an ellipsoid equation. When determining the variation in time of the surface position of the ellipsoid a vector approach is used. Findings. The geometry equations of the wave motion determine the volumes of material layers of the slab track involved in the interaction at a given time. The dynamic equilibrium determination of the deformed condition of the space bounded by the wave front makes it possible to calculate both the stresses and strains, and their changes during the time of the load perception. Thus, mathematical descriptions of the processes that occur in the perception of the load by the elements of railway track at high speeds were obtained. Originality. The simulation tasks of the track and rolling stock interaction, in particular taking into account the dynamic deflection of slab track were further developed. For the first time the article

An Integrated Modelling and Toolpathing Approach for a Frameless Stressed Skin Structure, Fabricated Using Robotic Incremental Sheet Forming

DEFF Research Database (Denmark)

Nicholas, Paul; Stasiuk, David; Nørgaard, Esben Clausen

2016-01-01

with performance implications at material, element and structural scales. This paper briefly presents ISF as a method of fabrication, and introduces the context of structures where the skin plays an integral role. It describes the development of an integrated approach for the modelling and fabrication of Stressed...... Skins, an incrementally formed sheet metal structure. The paper then focus upon the use of prototypes and empirical testing as means to inform digital models about fabrication and material parameters including: material forming limits and thinning; the parameterisation of macro and meso simulations...

Mean field diffusion models for precipitation in crystalline GaAs including surface tension and bulk stresses

Energy Technology Data Exchange (ETDEWEB)

Dreyer, Wolfgang [Weierstrass-Institut fuer Angewandte Analysis und Stochastik (WIAS) im Forschungsverbund Berlin e.V. (Germany); Kimmerle, Sven-Joachim [Humboldt-Univ. Berlin (Germany). Dept. of Mathematics

2009-07-01

Based on a thermodynamically consistent model for precipitation in gallium arsenide crystals including surface tension and bulk stresses by Dreyer and Duderstadt, we propose different mathematical models to describe the size evolution of liquid droplets in a crystalline solid. The first class of models treats the diffusion-controlled regime of interface motion, while the second class is concerned with the interface-controlled regime of interface motion. Our models take care of conservation of mass and substance. We consider homogenised models, where different length scales of the experimental situation have been exploited in order to simplify the equations. These homogenised models generalise the well-known Lifshitz-Slyozov-Wagner model for Ostwald ripening. Mean field models capture the main properties of our system and are well adapted for numerics and further analysis. Numerical evidence suggests in which case which one of the two regimes might be appropriate to the experimental situation. (orig.)

Behavioral changes over time in post-traumatic stress disorder: Insights from a rat model of single prolonged stress.

Science.gov (United States)

Wu, Zhuoyun; Tian, Qing; Li, Feng; Gao, Junqiao; Liu, Yan; Mao, Meng; Liu, Jing; Wang, Shuyan; Li, Genmao; Ge, Dongyu; Mao, Yingqiu; Zhang, Wei; Liu, Zhaolan; Song, Yuehan

2016-03-01

Post-traumatic stress disorder (PTSD) is manifested as a persistent mental and emotional condition after potentially life-threatening events. Different animal models of PTSD have been developed for neuro-pathophysiology and pharmacological evaluations. A single prolonged stress (SPS) induced animal model has demonstrated to result in specific neuro-endocrinological dysregulation, and behavior abnormalities observed in PTSD. However, animal studies of PTSD have mostly been performed at one time point after SPS exposure. To better understand the development of PTSD-like behaviors in the SPS animal model, and to identify an optimal period of study, we examined depressive behavior, anxiety-like behavior, physical activity and body weight in SPS model rats for two weeks. Our results confirmed the SPS-induced PTSD-like behavior and physical activity observed in previous studies, and indicated that the most pronounced symptomatic behavior changes were observed on day 1 and 7 after SPS exposure, which may involve stress-induced acute hormone changes and unclear secondary neurobiological changes, respectively. These results provide a solid basis for further investigation into the neuro-pathophysiology of or neuropharmacology for PTSD using the SPS rat model. However, for chronic (pharmacological) studies longer than 7 days, a prolonged PTSD animal model should be developed, perhaps using enhanced stimulation. Copyright © 2016 Elsevier B.V. All rights reserved.

Microscopic creep models and the interpretation of stress-dip tests during creep

International Nuclear Information System (INIS)

Poirier, J.P.

1976-09-01

A critical analysis is made of the principal divergent view points concerning stress-dip tests. The raw data are examined and interpreted in the light of various creep models. The following problems are discussed: is the reverse strain anelastic or plastic; is the zero creep rate periodic due to recovery or is it spurious; can the existence or inexistence of an internal stress be deduced from stress-dip tests; can stress-dip tests allow to determine whether glide is jerky or viscous; can the internal stress be measured by stress-dip tests

A kinetic model for stress generation in thin films grown from energetic vapor fluxes

Energy Technology Data Exchange (ETDEWEB)

Chason, E.; Karlson, M. [School of Engineering, Brown University, Providence, Rhode Island 02912 (United States); Colin, J. J.; Abadias, G. [Institut P' , Département Physique et Mécanique des Matériaux, Université de Poitiers-CNRS-ENSMA, SP2MI, Téléport 2, Bd M. et P. Curie, F-86962 Chasseneuil-Futuroscope (France); Magnfält, D.; Sarakinos, K. [Nanoscale Engineering Division, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83 Linköping (Sweden)

2016-04-14

We have developed a kinetic model for residual stress generation in thin films grown from energetic vapor fluxes, encountered, e.g., during sputter deposition. The new analytical model considers sub-surface point defects created by atomic peening, along with processes treated in already existing stress models for non-energetic deposition, i.e., thermally activated diffusion processes at the surface and the grain boundary. According to the new model, ballistically induced sub-surface defects can get incorporated as excess atoms at the grain boundary, remain trapped in the bulk, or annihilate at the free surface, resulting in a complex dependence of the steady-state stress on the grain size, the growth rate, as well as the energetics of the incoming particle flux. We compare calculations from the model with in situ stress measurements performed on a series of Mo films sputter-deposited at different conditions and having different grain sizes. The model is able to reproduce the observed increase of compressive stress with increasing growth rate, behavior that is the opposite of what is typically seen under non-energetic growth conditions. On a grander scale, this study is a step towards obtaining a comprehensive understanding of stress generation and evolution in vapor deposited polycrystalline thin films.

Frequency and Wavevector Dependence of the Atomic Level Stress-Stress Correlation Function in a Model Supercooled Liquid

Science.gov (United States)

Levashov, Valentin A.; Morris, James R.; Egami, Takeshi

2012-02-01

Temporal and spatial correlations among the local atomic level shear stresses were studied for a model liquid iron by molecular dynamics simulation [PRL 106,115703]. Integration over time and space of the shear stress correlation function F(r,t) yields viscosity via Green-Kubo relation. The stress correlation function in time and space F(r,t) was Fourier transformed to study the dependence on frequency, E, and wave vector, Q. The results, F(Q,E), showed damped shear stress waves propagating in the liquid for small Q at high and low temperatures. We also observed additional diffuse feature that appears as temperature is reduced below crossover temperature of potential energy landscape at relatively low frequencies at small Q. We suggest that this additional feature might be related to dynamic heterogeneity and boson peaks. We also discuss a relation between the time-scale of the stress-stress correlation function and the alpha-relaxation time of the intermediate self-scattering function S(Q,E).

A new coal-permeability model: Internal swelling stress and fracture-matrix interaction

Energy Technology Data Exchange (ETDEWEB)

Liu, H.H.; Rutqvist, J.

2009-10-01

We have developed a new coal-permeability model for uniaxial strain and constant confining stress conditions. The model is unique in that it explicitly considers fracture-matrix interaction during coal deformation processes and is based on a newly proposed internal-swelling stress concept. This concept is used to account for the impact of matrix swelling (or shrinkage) on fracture-aperture changes resulting from partial separation of matrix blocks by fractures that do not completely cut through the whole matrix. The proposed permeability model is evaluated with data from three Valencia Canyon coalbed wells in the San Juan Basin, where increased permeability has been observed during CH{sub 4} gas production, as well as with published data from laboratory tests. Model results are generally in good agreement with observed permeability changes. The importance of fracture-matrix interaction in determining coal permeability, demonstrated in this work using relatively simple stress conditions, underscores the need for a dual-continuum (fracture and matrix) mechanical approach to rigorously capture coal-deformation processes under complex stress conditions, as well as the coupled flow and transport processes in coal seams.

GAD65 haplodeficiency conveys resilience in animal models of stress-induced psychopathology

Directory of Open Access Journals (Sweden)

Iris eMüller

2014-08-01

Full Text Available GABAergic mechanisms are critically involved in the control of fear and anxiety, but their role in the development of stress-induced psychopathologies, including post-traumatic stress disorder (PTSD and mood disorders is not sufficiently understood. We studied these functions in two established mouse models of risk factors for stress-induced psychopathologies employing variable juvenile stress and/or social isolation. A battery of emotional tests in adulthood revealed the induction of contextually generalized fear, anxiety, hyperarousal and depression-like symptoms in these paradigms. These reflect the multitude and complexity of stress effects in human PTSD patients. With factor analysis we were able to identify parameters that reflect these different behavioral domains in stressed animals and thus provide a basis for an integrated scoring of affectedness more closely resembling the clinical situation than isolated parameters. To test the applicability of these models to genetic approaches we further tested the role of GABA using heterozygous mice with targeted mutation of the GABA synthesizing enzyme GAD65 (GAD65+/- mice, which show a delayed postnatal increase in tissue GABA content in limbic and cortical brain areas. Unexpectedly, GAD65(+/- mice did not show changes in exploratory activity regardless of the stressor type and were after the variable juvenile stress procedure protected from the development of contextual generalization in an auditory fear conditioning experiment. Our data demonstrate the complex nature of behavioral alterations in rodent models of stress-related psychopathologies and suggest that GAD65 haplodeficiency, likely through its effect on the postnatal maturation of GABAergic transmission, conveys resilience to some of these stress-induced effects.

Residual stress behaviors induced by laser peening along the edge of curved models

International Nuclear Information System (INIS)

Im, Jong Bin; Grandhi, Ramana V.; Ro, Young Hee

2012-01-01

Laser peening (LP) induces high magnitude compressive residual stresses in a small region of a component. The compressive residual stresses cause plastic deformation that is resistant to fatigue fracture. Fatigue cracks are generally nucleated at critical areas, and LP is applied for those regions so as to delay the crack initiation. Many critical regions are located on the edge of the curved portion of structures because of stress concentration effects. Several investigations that are available for straight components may not give meaningful guidelines for peening curved components. Therefore, in this paper, we investigate residual stress behaviors induced by LP along the edge of curved models. Three curved models that have different curvatures are investigated for peening performance. Two types of peening configurations, which are simultaneous corner shot and sequential corner shots, are considered in order to obtain compressive residual stresses along an edge. LP simulations of multiple shots are performed to identify overlapping effects on the edge portion of a curved model. In addition, the uncertainty calculation of residual stress induced by LP considering laser pulse duration is performed

Modelling Of Residual Stresses Induced By High Speed Milling Process

International Nuclear Information System (INIS)

Desmaison, Olivier; Mocellin, Katia; Jardin, Nicolas

2011-01-01

Maintenance processes used in heavy industries often include high speed milling operations. The reliability of the post-process material state has to be studied. Numerical simulation appears to be a very interesting way to supply an efficient residual stresses (RS) distribution prediction.Because the adiabatic shear band and the serrated chip shaping are features of the austenitic stainless steel high speed machining, a 2D high speed orthogonal cutting model is briefly presented. This finite element model, developed on Forge registered software, is based on data taken from Outeiro and al.'s paper [1]. A new behaviour law fully coupling Johnson-Cook's constitutive law and Latham and Cockcroft's damage model is detailed in this paper. It ensures results that fit those found in literature.Then, the numerical tools used on the 2D model are integrated to a 3D high speed milling model. Residual stresses distribution is analysed, on the surface and into the depth of the material. Various revolutions and passes of the two teeth hemispheric mill on the workpiece are simulated. Thus the sensitivity of the residual stresses generation to the cutting conditions can be discussed. In order to validate the 3D model, a comparison of the cutting forces measured by EDF R and D to those given by numerical simulations is achieved.

Describing Soils: Calibration Tool for Teaching Soil Rupture Resistance

Science.gov (United States)

Seybold, C. A.; Harms, D. S.; Grossman, R. B.

2009-01-01

Rupture resistance is a measure of the strength of a soil to withstand an applied stress or resist deformation. In soil survey, during routine soil descriptions, rupture resistance is described for each horizon or layer in the soil profile. The lower portion of the rupture resistance classes are assigned based on rupture between thumb and…

Animal Models of Post-Traumatic Stress Disorder and Recent Neurobiological Insights

Science.gov (United States)

Whitaker, Annie M.; Gilpin, Nicholas W.; Edwards, Scott

2014-01-01

Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder characterized by the intrusive re-experiencing of past trauma, avoidant behavior, enhanced fear, and hyperarousal following a traumatic event in vulnerable populations. Preclinical animal models do not replicate the human condition in its entirety, but seek to mimic symptoms or endophenotypes associated with PTSD. Although many models of traumatic stress exist, few adequately capture the complex nature of the disorder and the observed individual variability in susceptibility of humans to develop PTSD. In addition, various types of stressors may produce different molecular neuroadaptations that likely contribute to the various behavioral disruptions produced by each model, although certain consistent neurobiological themes related to PTSD have emerged. For example, animal models report traumatic stress- and trauma reminder-induced alterations in neuronal activity in the amygdala and prefrontal cortex, in agreement with the human PTSD literature. Models have also provided a conceptual framework for the often observed combination of PTSD and co-morbid conditions such as alcohol use disorder (AUD). Future studies will continue to refine preclinical PTSD models in hopes of capitalizing on their potential to deliver new and more efficacious treatments for PTSD and associated psychiatric disorders. PMID:25083568

Modeling of the attenuation of stress waves in concrete based on the Rayleigh damping model using time-reversal and PZT transducers

Science.gov (United States)

Tian, Zhen; Huo, Linsheng; Gao, Weihang; Li, Hongnan; Song, Gangbing

2017-10-01

Wave-based concrete structural health monitoring has attracted much attention. A stress wave experiences significant attenuation in concrete, however there is a lack of a unified method for predicting the attenuation coefficient of the stress wave. In this paper, a simple and effective absorption attenuation model of stress waves in concrete is developed based on the Rayleigh damping model, which indicates that the absorption attenuation coefficient of stress waves in concrete is directly proportional to the square of the stress wave frequency when the damping ratio is small. In order to verify the theoretical model, related experiments were carried out. During the experiments, a concrete beam was designed in which the d33-model piezoelectric smart aggregates were embedded to detect the propagation of stress waves. It is difficult to distinguish direct stress waves due to the complex propagation paths and the reflection and scattering of stress waves in concrete. Hence, as another innovation of this paper, a new method for computing the absorption attenuation coefficient based on the time-reversal method is developed. Due to the self-adaptive focusing properties of the time-reversal method, the time-reversed stress wave focuses and generates a peak value. The time-reversal method eliminates the adverse effects of multipaths, reflection, and scattering. The absorption attenuation coefficient is computed by analyzing the peak value changes of the time-reversal focused signal. Finally, the experimental results are found to be in good agreement with the theoretical model.

A comparison of macroscopic models describing the collective response of sedimenting rod-like particles in shear flows

KAUST Repository

Helzel, Christiane; Tzavaras, Athanasios

2016-01-01

We consider a kinetic model, which describes the sedimentation of rod-like particles in dilute suspensions under the influence of gravity, presented in Helzel and Tzavaras (submitted for publication). Here we restrict our considerations to shear flow and consider a simplified situation, where the particle orientation is restricted to the plane spanned by the direction of shear and the direction of gravity. For this simplified kinetic model we carry out a linear stability analysis and we derive two different nonlinear macroscopic models which describe the formation of clusters of higher particle density. One of these macroscopic models is based on a diffusive scaling, the other one is based on a so-called quasi-dynamic approximation. Numerical computations, which compare the predictions of the macroscopic models with the kinetic model, complete our presentation.

A comparison of macroscopic models describing the collective response of sedimenting rod-like particles in shear flows

KAUST Repository

Helzel, Christiane

2016-07-22

We consider a kinetic model, which describes the sedimentation of rod-like particles in dilute suspensions under the influence of gravity, presented in Helzel and Tzavaras (submitted for publication). Here we restrict our considerations to shear flow and consider a simplified situation, where the particle orientation is restricted to the plane spanned by the direction of shear and the direction of gravity. For this simplified kinetic model we carry out a linear stability analysis and we derive two different nonlinear macroscopic models which describe the formation of clusters of higher particle density. One of these macroscopic models is based on a diffusive scaling, the other one is based on a so-called quasi-dynamic approximation. Numerical computations, which compare the predictions of the macroscopic models with the kinetic model, complete our presentation.

The interpretation of stress reductions in creep-fatigue cycles of 316 stainless steel

International Nuclear Information System (INIS)

Hales, R.

1986-11-01

A statistical analysis of stress-drop results obtained on a number of different casts of 316 stainless steel in the temperature range 550 0 C to 700 0 C is presented. In all cases the results were obtained from strain controlled fatigue tests. The equations used to describe stress relaxation here are derived from forward creep equations which describe the dependence of creep rate on time, stress and temperature. Although there is no clear correspondence between creep and stress relaxation, creep equations offer an attractive starting point. Not all the models considered exhibited the expected response to changes in temperature. A revised analysis was carried out on the assumption that stress relaxation is thermally activated according to the Arrhenius equation. Two models were found to fit the data equally well and it was not possible to choose which of these relationships is the more appropriate to describe stress relaxation of cyclically conditioned material. On the basis of the evidence both are acceptable and may be used to calculate the creep damage according to the various high temperature design codes. Whichever gives the more conservative assessment should be used until a more mechanistically based judgement can be reached. (author)

Predicting NonInertial Effects with Algebraic Stress Models which Account for Dissipation Rate Anisotropies

Science.gov (United States)

Jongen, T.; Machiels, L.; Gatski, T. B.

1997-01-01

Three types of turbulence models which account for rotational effects in noninertial frames of reference are evaluated for the case of incompressible, fully developed rotating turbulent channel flow. The different types of models are a Coriolis-modified eddy-viscosity model, a realizable algebraic stress model, and an algebraic stress model which accounts for dissipation rate anisotropies. A direct numerical simulation of a rotating channel flow is used for the turbulent model validation. This simulation differs from previous studies in that significantly higher rotation numbers are investigated. Flows at these higher rotation numbers are characterized by a relaminarization on the cyclonic or suction side of the channel, and a linear velocity profile on the anticyclonic or pressure side of the channel. The predictive performance of the three types of models are examined in detail, and formulation deficiencies are identified which cause poor predictive performance for some of the models. Criteria are identified which allow for accurate prediction of such flows by algebraic stress models and their corresponding Reynolds stress formulations.

The Inclusion of Arbitrary Load Histories in the Strength Decay Model for Stress Rupture

Science.gov (United States)

Reeder, James R.

2014-01-01

Stress rupture is a failure mechanism where failures can occur after a period of time, even though the material has seen no increase in load. Carbon/epoxy composite materials have demonstrated the stress rupture failure mechanism. In a previous work, a model was proposed for stress rupture of composite overwrap pressure vessels (COPVs) and similar composite structures based on strength degradation. However, the original model was limited to constant load periods (holds) at constant load. The model was expanded in this paper to address arbitrary loading histories and specifically the inclusions of ramp loadings up to holds and back down. The broadening of the model allows for failures on loading to be treated as any other failure that may occur during testing instead of having to be treated as a special case. The inclusion of ramps can also influence the length of the "safe period" following proof loading that was previously predicted by the model. No stress rupture failures are predicted in a safe period because time is required for strength to decay from above the proof level to the lower level of loading. Although the model can predict failures during the ramp periods, no closed-form solution for the failure times could be derived. Therefore, two suggested solution techniques were proposed. Finally, the model was used to design an experiment that could detect the difference between the strength decay model and a commonly used model for stress rupture. Although these types of models are necessary to help guide experiments for stress rupture, only experimental evidence will determine how well the model may predict actual material response. If the model can be shown to be accurate, current proof loading requirements may result in predicted safe periods as long as 10(13) years. COPVs design requirements for stress rupture may then be relaxed, allowing more efficient designs, while still maintaining an acceptable level of safety.

Development of the model describing highly excited states of odd deformed nuclei

International Nuclear Information System (INIS)

Malov, L.A.; Solov'ev, V.G.

1975-01-01

An approximate method is given for solving the system of equations obtained earlier for describing the structure of states with intermediate and high energies in the framework of the model taking into account the interaction of quasiparticles with phonons. The new method possesses a number of advantages over the approximate methods of solving the system of equations mentioned. The study is performed for the example of an odd deformed nucleus when several one-quasiparticle components are taken into account at the same time

Statistical model of stress corrosion cracking based on extended

Indian Academy of Sciences (India)

The mechanism of stress corrosion cracking (SCC) has been discussed for decades. Here I propose a model of SCC reflecting the feature of fracture in brittle manner based on the variational principle under approximately supposed thermal equilibrium. In that model the functionals are expressed with extended forms of ...

BILAM: a composite laminate failure-analysis code using bilinear stress-strain approximations

Energy Technology Data Exchange (ETDEWEB)

McLaughlin, P.V. Jr.; Dasgupta, A.; Chun, Y.W.

1980-10-01

The BILAM code which uses constant strain laminate analysis to generate in-plane load/deformation or stress/strain history of composite laminates to the point of laminate failure is described. The program uses bilinear stress-strain curves to model layer stress-strain behavior. Composite laminates are used for flywheels. The use of this computer code will help to develop data on the behavior of fiber composite materials which can be used by flywheel designers. In this program the stress-strain curves are modelled by assuming linear response in axial tension while using bilinear approximations (2 linear segments) for stress-strain response to axial compressive, transverse tensile, transverse compressive and axial shear loadings. It should be noted that the program attempts to empirically simulate the effects of the phenomena which cause nonlinear stress-strain behavior, instead of mathematically modelling the micromechanics involved. This code, therefore, performs a bilinear laminate analysis, and, in conjunction with several user-defined failure interaction criteria, is designed to provide sequential information on all layer failures up to and including the first fiber failure. The modus operandi is described. Code BILAM can be used to: predict the load-deformation/stress-strain behavior of a composite laminate subjected to a given combination of in-plane loads, and make analytical predictions of laminate strength.

Residual stress distribution analysis of heat treated APS TBC using image based modelling.

Science.gov (United States)

Li, Chun; Zhang, Xun; Chen, Ying; Carr, James; Jacques, Simon; Behnsen, Julia; di Michiel, Marco; Xiao, Ping; Cernik, Robert

2017-08-01

We carried out a residual stress distribution analysis in a APS TBC throughout the depth of the coatings. The samples were heat treated at 1150 °C for 190 h and the data analysis used image based modelling based on the real 3D images measured by Computed Tomography (CT). The stress distribution in several 2D slices from the 3D model is included in this paper as well as the stress distribution along several paths shown on the slices. Our analysis can explain the occurrence of the "jump" features near the interface between the top coat and the bond coat. These features in the residual stress distribution trend were measured (as a function of depth) by high-energy synchrotron XRD (as shown in our related research article entitled 'Understanding the Residual Stress Distribution through the Thickness of Atmosphere Plasma Sprayed (APS) Thermal Barrier Coatings (TBCs) by high energy Synchrotron XRD; Digital Image Correlation (DIC) and Image Based Modelling') (Li et al., 2017) [1].

Peer pressures: Social instability stress in adolescence and social deficits in adulthood in a rodent model

Directory of Open Access Journals (Sweden)

Cheryl M. McCormick

2015-02-01

Full Text Available Studies in animal models generate and test hypotheses regarding developmental stage-specific vulnerability that might inform research questions about human development. In both rats and humans, peer relationships are qualitatively different in adolescence than at other stages of development, and social experiences in adolescence are considered important determinants of adult social function. This review describes our adolescent rat social instability stress model and the long-lasting effects social instability has on social behaviour in adulthood as well as the possible neural underpinnings. Effects of other adolescent social stress experiences in rats on social behaviours in adulthood also are reviewed. We discuss the role of hypothalamic–pituitary–adrenal (HPA function and glucocorticoid release in conferring differential susceptibility to social experiences in adolescents compared to adults. We propose that although differential perception of social experiences rather than immature HPA function may underlie the heightened vulnerability of adolescents to social instability, the changes in the trajectory of brain development and resultant social deficits likely are mediated by the heightened glucocorticoid release in response to repeated social stressors in adolescence compared to in adulthood.

Reliability of Coulomb stress changes inferred from correlated uncertainties of finite-fault source models

KAUST Repository

Woessner, J.; Jonsson, Sigurjon; Sudhaus, H.; Baumann, C.

2012-01-01

Static stress transfer is one physical mechanism to explain triggered seismicity. Coseismic stress-change calculations strongly depend on the parameterization of the causative finite-fault source model. These models are uncertain due

Three-dimensional modelling of thermal stress in floating zone silicon crystal growth

Science.gov (United States)

Plate, Matiss; Krauze, Armands; Virbulis, Jānis

2018-05-01

During the growth of large diameter silicon single crystals with the industrial floating zone method, undesirable level of thermal stress in the crystal is easily reached due to the inhomogeneous expansion as the crystal cools down. Shapes of the phase boundaries, temperature field and elastic material properties determine the thermal stress distribution in the solid mono crystalline silicon during cylindrical growth. Excessive stress can lead to fracture, generation of dislocations and altered distribution of intrinsic point defects. Although appearance of ridges on the crystal surface is the decisive factor of a dislocation-free growth, the influence of these ridges on the stress field is not completely clear. Here we present the results of thermal stress analysis for 4” and 5” diameter crystals using a quasi-stationary three dimensional mathematical model including the material anisotropy and the presence of experimentally observed ridges which cannot be addressed with axis-symmetric models. The ridge has a local but relatively strong influence on thermal stress therefore its relation to the origin of fracture is hypothesized. In addition, thermal stresses at the crystal rim are found to increase for a particular position of the crystal radiation reflector.

Animal models of surgically manipulated flow velocities to study shear stress-induced atherosclerosis.

Science.gov (United States)

Winkel, Leah C; Hoogendoorn, Ayla; Xing, Ruoyu; Wentzel, Jolanda J; Van der Heiden, Kim

2015-07-01

Atherosclerosis is a chronic inflammatory disease of the arterial tree that develops at predisposed sites, coinciding with locations that are exposed to low or oscillating shear stress. Manipulating flow velocity, and concomitantly shear stress, has proven adequate to promote endothelial activation and subsequent plaque formation in animals. In this article, we will give an overview of the animal models that have been designed to study the causal relationship between shear stress and atherosclerosis by surgically manipulating blood flow velocity profiles. These surgically manipulated models include arteriovenous fistulas, vascular grafts, arterial ligation, and perivascular devices. We review these models of manipulated blood flow velocity from an engineering and biological perspective, focusing on the shear stress profiles they induce and the vascular pathology that is observed. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

A global model of stress in parents of individuals with autism spectrum disorders (ASD

Directory of Open Access Journals (Sweden)

Pilar Pozo

2014-01-01

Full Text Available This research sought to analyse stress among mothers and fathers of individuals with autism spectrum disorders (ASD to determine the relevant variables for its explanation and the possible gender differences. To examine parents' stress, we propose a multidimensional model based on the Double ABCX theoretical model. We argue that the result of stress depends on the following four interrelated factors: the characteristics of the individual with ASD (the severity of the disorder and behaviour problems, the social supports, the parents' perception of the situation (evaluated by sense of coherence and the coping strategies. Fiftynine sets of parents (59 mothers and 59 fathers of individuals diagnosed with ASD participated in the study. The data were analysed using a path analysis through the LISREL 8.80 program. We obtained two empirical models of stress: one model for mothers and one for fathers. In both models, the severity of the disorder and the behaviour problems had a direct and positive effect on stress. The sense of coherence (SOC and active avoidance coping strategies had a mediating role in models. Social support was relevant only for mothers. Finally, the results offer some guidelines for professionals working with families.

Alcohol, psychomotor-stimulants and behaviour: methodological considerations in preclinical models of early-life stress.

Science.gov (United States)

McDonnell-Dowling, Kate; Miczek, Klaus A

2018-04-01

In order to assess the risk associated with early-life stress, there has been an increase in the amount of preclinical studies investigating early-life stress. There are many challenges associated with investigating early-life stress in animal models and ensuring that such models are appropriate and clinically relevant. The purpose of this review is to highlight the methodological considerations in the design of preclinical studies investigating the effects of early-life stress on alcohol and psychomotor-stimulant intake and behaviour. The protocols employed for exploring early-life stress were investigated and summarised. Experimental variables include animals, stress models, and endpoints employed. The findings in this paper suggest that there is little consistency among these studies and so the interpretation of these results may not be as clinically relevant as previously thought. The standardisation of these simple stress procedures means that results will be more comparable between studies and that results generated will give us a more robust understanding of what can and may be happening in the human and veterinary clinic.

DECOVALEX I - Test Case 1: Coupled stress-flow model

International Nuclear Information System (INIS)

Rosengren, L.; Christianson, M.

1995-12-01

This report presents the results of the coupled stress-flow model, test case 1 of Decovalex. The model simulates the fourth loading cycle of a coupled stress-flow test and subsequent shearing up to and beyond peak shear resistance. The first loading sequence (A) consists of seven normal loading steps: 0, 5, 15, 25, 15, 5, 0 MPa. The second loading sequence (B) consists of the following eight steps: unstressed state, normal boundary loading of 25 MPa (no shearing), and then shearing of 0.5, 0.8, 2, 4, 2, 0 mm. Two different options regarding the rock joint behaviour were modeled in accordance with the problem definition. In option 1 a linear elastic joint model with Coulomb slip criterion was used. In option 2 a non-linear empirical (i.e. Barton-Bandis) joint model was used. The hydraulic condition during both load sequence A and B was a constant head of 5 m at the inlet point and 0 m at the outlet point. All model runs presented in this report were performed using the two-dimensional distinct element computer code UDEC, version 1.8. 30 refs, 36 figs

Numerical modeling of regional stress distributions for geothermal exploration

Science.gov (United States)

Guillon, Theophile; Peter-Borie, Mariane; Gentier, Sylvie; Blaisonneau, Arnold

2017-04-01

Any high-enthalpy unconventional geothermal projectcan be jeopardized by the uncertainty on the presence of the geothermal resource at depth. Indeed, for the majority of such projects the geothermal resource is deeply seated and, with the drilling costs increasing accordingly, must be located as precisely as possible to increase the chance of their economic viability. In order to reduce the "geological risk", i.e., the chance to poorly locate the geothermal resource, a maximum amount of information must be gathered prior to any drilling of exploration and/or operational well. Cross-interpretation from multiple disciplines (e.g., geophysics, hydrology, geomechanics …) should improve locating the geothermal resource and so the position of exploration wells ; this is the objective of the European project IMAGE (grant agreement No. 608553), under which the work presented here was carried out. As far as geomechanics is concerned, in situ stresses can have a great impact on the presence of a geothermal resource since they condition both the regime within the rock mass, and the state of the major fault zones (and hence, the possible flow paths). In this work, we propose a geomechanical model to assess the stress distribution at the regional scale (characteristic length of 100 kilometers). Since they have a substantial impact on the stress distributions and on the possible creation of regional flow paths, the major fault zones are explicitly taken into account. The Distinct Element Method is used, where the medium is modeled as fully deformable blocks representing the rock mass interacting through mechanically active joints depicting the fault zones. The first step of the study is to build the model geometry based on geological and geophysical evidences. Geophysical and structural geology results help positioning the major fault zones in the first place. Then, outcrop observations, structural models and site-specific geological knowledge give information on the fault

Yield stress of alumina-zirconia suspensions

International Nuclear Information System (INIS)

Ramakrishnan, V.; Pradip; Malghan, S.G.

1996-01-01

The yield stress of concentrated suspensions of alumina, zirconia, and mixed alumina-zirconia powders was measured by the vane technique as a function of solids loading, relative amounts of alumina and zirconia, and pH. At the isoelectric point (IEP), the yield stress varied as the fourth power of the solids loading. The relative ratio of alumina and zirconia particles was important in determining the yield stress of the suspension at the IEP. The yield stress of single and mixed suspensions showed a marked variation with pH. The maximum value occurred at or near the IEP of the suspension. The effect of electrical double-layer forces on the yield stress can be described on the basis of the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. A normalized yield stress--that is, the ratio of the yield stress at a given pH to the yield stress at the IEP predicted by this model--showed good correlation with experimental data

Robustness of a cross contamination model describing transfer of pathogens during grinding of meat

DEFF Research Database (Denmark)

Møller, Cleide Oliveira de Almeida; Sant’Ana, A. S.; Hansen, Solvej Katrine Holm

2016-01-01

This study aimed to evaluate a cross contamination model for its capability of describing transfer of Salmonella spp. and L. monocytogenes during grinding of varying sizes and numbers of pieces of meats in two grinder systems. Data from 19 trials were collected. Three evaluation approaches were...

Bridging scales of crustal stress patterns using the new World Stress Map

Science.gov (United States)

Heidbach, O.; Rajabi, M.; Cui, X.; Fuchs, K. W.; Mueller, B.; Reinecker, J.; Reiter, K.; Tingay, M. R. P.; Wenzel, F.; Xie, F.; Ziegler, M.; Zoback, M. D.; Zoback, M. L.

2017-12-01

geomechanical-numerical model workflow based on the WSM data to describe the in situ stress tensor. 3D Geomechanical-numerical modelling of the in situ stress state is essential to derive a continuous description of the stress tensor e.g. in order to estimate the distance to a critical stress state.

Viscoelastic stress modeling in cementitious materials using constant viscoelastic hydration modulus

NARCIS (Netherlands)

Hansen, W.; Liu, Z.; Koenders, E.A.B.

2014-01-01

Viscoelastic stress modeling in ageing cementitious materials is of major importance in high performance concrete of low water cement ratio (e.g. w/c ~0.35) where crack resistance due to deformation restraint needs to be determined. Total stress analysis is complicated by the occurrence of internal

The Effect of Occupational Stress on Health and Illness: A Model.

Science.gov (United States)

Taylor, William L.; Cangemi, Joseph P.

1988-01-01

Examines brief history of stress research and concludes that psychological factors can affect job satisfaction, work adjustment, work attitudes, and overall well-being in the work environment. Establishes relationship between mental and physiological functioning disturbances. Presents model relating effect of stress on health and illness. (Author)

The reservoir model: a differential equation model of psychological regulation.

Science.gov (United States)

Deboeck, Pascal R; Bergeman, C S

2013-06-01

Differential equation models can be used to describe the relationships between the current state of a system of constructs (e.g., stress) and how those constructs are changing (e.g., based on variable-like experiences). The following article describes a differential equation model based on the concept of a reservoir. With a physical reservoir, such as one for water, the level of the liquid in the reservoir at any time depends on the contributions to the reservoir (inputs) and the amount of liquid removed from the reservoir (outputs). This reservoir model might be useful for constructs such as stress, where events might "add up" over time (e.g., life stressors, inputs), but individuals simultaneously take action to "blow off steam" (e.g., engage coping resources, outputs). The reservoir model can provide descriptive statistics of the inputs that contribute to the "height" (level) of a construct and a parameter that describes a person's ability to dissipate the construct. After discussing the model, we describe a method of fitting the model as a structural equation model using latent differential equation modeling and latent distribution modeling. A simulation study is presented to examine recovery of the input distribution and output parameter. The model is then applied to the daily self-reports of negative affect and stress from a sample of older adults from the Notre Dame Longitudinal Study on Aging. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

Stress variations during a glacial cycle at 500 m depth in Forsmark and Oskarshamn: Earth model effects

Energy Technology Data Exchange (ETDEWEB)

Lund, Bjoern [Uppsala Univ. (Sweden). Dept. of Earth Sciences

2006-06-15

This study has considered the response to a glaciation of Earth models of increasingly complex structure in elastic parameters and viscosity. The models are one-dimensional in the sense that they vary only in the depth direction, i.e. there are only uniform, horizontal layers in the models. I find that as the complexity of the models increase, and the properties of the uppermost kilometer of the Earth become less affected by average properties from deeper down, the flexural stresses at 500 m depth decrease, as expected. A lower Young's modulus, lower compressibility and lower density in the uppermost layer all act to lower the stresses. However, the three properties act differently on the resulting response. Introducing layering in Young's modulus generally decreases the stresses all along a profile through the ice model. Going from incompressible to compressible models affect the stresses outside the ice edge significantly more than the stresses under the ice sheet. Introducing layering in density conversely affect the stresses under the ice sheet more than those outside the ice edge. The combined effects of the most complex models tested here show that the glacially induced horizontal stresses at 500 m depth decrease to levels very similar in magnitude to the loading stress. There are, however, temporal variations in these horizontal stresses that do not follow the loading stress and which induce tensional or compressional horizontal stresses that persist when no ice is present.As is well known, changes in viscosity structure has a very large effect on the Earth response. Viscosity affect both the magnitudes of the induced stresses and the temporal behavior of the stress evolution. This is confirmed in the current study.The glacially induced stresses for some of the models have been used in combination with the current background stress field at Forsmark and Oskarshamn, as estimated in SKB's site models, to evaluate fault stability throughout a

Stress variations during a glacial cycle at 500 m depth in Forsmark and Oskarshamn: Earth model effects