LHC Status and Upgrade Challenges

Science.gov (United States)

Smith, Jeffrey

2009-11-01

The Large Hadron Collider has had a trying start-up and a challenging operational future lays ahead. Critical to the machine's performance is controlling a beam of particles whose stored energy is equivalent to 80 kg of TNT. Unavoidable beam losses result in energy deposition throughout the machine and without adequate protection this power would result in quenching of the superconducting magnets. A brief overview of the machine layout and principles of operation will be reviewed including a summary of the September 2008 accident. The current status of the LHC, startup schedule and upgrade options to achieve the target luminosity will be presented.

Smart grid demonstrators and experiments in France: Economic assessments of smart grids. Challenges, methods, progress status and demonstrators; Contribution of 'smart grid' demonstrators to electricity transport and market architectures; Challenges and contributions of smart grid demonstrators to the distribution network. Focus on the integration of decentralised production; Challenges and contributions of smart grid demonstrators to the evolution of providing-related professions and to consumption practices

International Nuclear Information System (INIS)

Sudret, Thierry; Belhomme, Regine; Nekrassov, Andrei; Chartres, Sophie; Chiappini, Florent; Drouineau, Mathilde; Hadjsaid, Nouredine; Leonard, Cedric; Bena, Michel; Buhagiar, Thierry; Lemaitre, Christian; Janssen, Tanguy; Guedou, Benjamin; Viana, Maria Sebastian; Malarange, Gilles; Hadjsaid, Nouredine; Petit, Marc; Lehec, Guillaume; Jahn, Rafael; Gehain, Etienne

2015-01-01

This publication proposes a set of four articles which give an overview of challenges and contributions of smart grid demonstrators for the French electricity system according to different perspectives and different stakeholders. These articles present the first lessons learned from these demonstrators in terms of technical and technological innovations, of business and regulation models, and of customer behaviour and acceptance. More precisely, the authors discuss economic assessments of smart grids with an overview of challenges, methods, progress status and existing smart grid programs in the World, comment the importance of the introduction of intelligence at hardware, software and market level, highlight the challenges and contributions of smart grids for the integration of decentralised production, and discuss how smart grid demonstrators impact providing-related professions and customer consumption practices

Progress, status, and plans for the HRIBF project

International Nuclear Information System (INIS)

Auble, R.L.; Alton, G.D.; Bailey, J.D.

1995-01-01

Over the last three years, the Holifield accelerator system has been reconfigured into a first-generation radioactive ion beam facility, the HRIBF, a national user facility for RIB research. The construction and reconfiguration have been completed and the equipment commissioning and beam development phases have started. The progress to date, the present status, and future plans will be given. The special problems connected with the production and acceleration of RIBs will be discussed

Candidiasis: a fungal infection--current challenges and progress in prevention and treatment.

Science.gov (United States)

Hani, Umme; Shivakumar, Hosakote G; Vaghela, Rudra; Osmani, Riyaz Ali M; Shrivastava, Atul

2015-01-01

Despite therapeutic advances candidiasis remains a common fungal infection most frequently caused by C. albicans and may occur as vulvovaginal candidiasis or thrush, a mucocutaneous candidiasis. Candidiasis frequently occurs in newborns, in immune-deficient people like AIDS patients, and in people being treated with broad spectrum antibiotics. It is mainly due to C. albicans while other species such as C. tropicalis, C. glabrata, C. parapsilosis and C. krusei are increasingly isolated. OTC antifungal dosage forms such as creams and gels can be used for effective treatment of local candidiasis. Whereas, for preventing spread of the disease to deeper vital organs, candidiasis antifungal chemotherapy is preferred. Use of probiotics and development of novel vaccines is an advanced approach for the prevention of candidiasis. Present review summarizes the diagnosis, current status and challenges in the treatment and prevention of candidiasis with prime focus on host defense against candidiasis, advancements in diagnosis, probiotics role and recent progress in the development of vaccines against candidiasis.

Measles and rubella elimination in the WHO Region for Europe: progress and challenges.

Science.gov (United States)

O'Connor, P; Jankovic, D; Muscat, M; Ben-Mamou, M; Reef, S; Papania, M; Singh, S; Kaloumenos, T; Butler, R; Datta, S

2017-08-01

Globally measles remains one of the leading causes of death among young children even though a safe and cost-effective vaccine is available. The World Health Organization (WHO) European Region has seen a decline in measles and rubella cases in recent years. The recent outbreaks have primarily affected adolescents and young adults with no vaccination or an incomplete vaccination history. Eliminating measles and rubella is one of the top immunization priorities of the European Region as outlined in the European Vaccine Action Plan 2015-2020. Following the 2010 decision by the Member States in the Region to initiate the process of verifying elimination, the European Regional Verification Commission for Measles and Rubella Elimination (RVC) was established in 2011. The RVC meets every year to evaluate the status of measles and rubella elimination in the Region based on documentation submitted by each country's National Verification Committees. The verification process was however modified in late 2014 to assess the elimination status at the individual country level instead of at regional level. The WHO European Region has made substantial progress towards measles and rubella elimination over the past 5 years. The RVC's conclusion in 2016 that 70% and 66% of the 53 Member States in the Region had interrupted the endemic transmission of measles and rubella, respectively, by 2015 is a testament to this progress. Nevertheless, where measles and rubella remain endemic, challenges in vaccination service delivery and disease surveillance will need to be addressed through focused technical assistance from WHO and development partners. Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Progress and challenges in implementing the women, peace and ...

African Journals Online (AJOL)

This article provides an initial overview of the African Union's progress and challenges in implementing the Women, Peace and Security (WPS) agenda in its peace and security architecture. It reviews implementation in relation to representation, programming and in peacekeeping. The article contends that the WPS agenda ...

Therapeutic strategies to fight HIV-1 latency: progress and challenges

CSIR Research Space (South Africa)

Manoto, Sello L

2017-10-01

Full Text Available —1112, 2017 Therapeutic strategies to fight HIV-1 latency: progress and challenges Sello Lebohang Manoto, Lebogang Thobakgale, Rudzani Malabi, Charles Maphanga, Saturnin Ombinda-Lemboumba, Patience Mthunzi-Kufa Abstract: The life...

Androgen receptor status is highly conserved during tumor progression of breast cancer.

Science.gov (United States)

Grogg, André; Trippel, Mafalda; Pfaltz, Katrin; Lädrach, Claudia; Droeser, Raoul A; Cihoric, Nikola; Salhia, Bodour; Zweifel, Martin; Tapia, Coya

2015-11-09

With the advent of new and more efficient anti-androgen drugs targeting androgen receptor (AR) in breast cancer (BC) is becoming an increasingly important area of investigation. This would potentially be most useful in triple negative BC (TNBC), where better therapies are still needed. The assessment of AR status is generally performed on the primary tumor even if the tumor has already metastasized. Very little is known regarding discrepancies of AR status during tumor progression. To determine the prevalence of AR positivity, with emphasis on TNBCs, and to investigate AR status during tumor progression, we evaluated a large series of primary BCs and matching metastases and recurrences. AR status was performed on 356 primary BCs, 135 matching metastases, and 12 recurrences using a next-generation Tissue Microarray (ngTMA). A commercially available AR antibody was used to determine AR-status by immunohistochemistry. AR positivity was defined as any nuclear staining in tumor cells ≥1 %. AR expression was correlated with pathological tumor features of the primary tumor. Additionally, the concordance rate of AR expression between the different tumor sites was determined. AR status was positive in: 87 % (307/353) of primary tumors, 86.1 % (105/122) of metastases, and in 66.7 % (8/12) of recurrences. TNBC tested positive in 11.4 %, (4/35) of BCs. A discrepant result was seen in 4.3 % (5/117) of primary BC and matching lymph node (LN) metastases. Three AR negative primary BCs were positive in the matching LN metastasis, representing 17.6 % of all negative BCs with lymph node metastases (3/17). Two AR positive primary BCs were negative in the matching LN metastasis, representing 2.0 % of all AR positive BCs with LN metastases (2/100). No discrepancies were seen between primary BC and distant metastases or recurrence (n = 17). Most primary (87 %) and metastasized (86.1 %) BCs are AR positive including a significant fraction of TNBCs (11.4 %). Further, AR status is

Androgen receptor status is highly conserved during tumor progression of breast cancer

International Nuclear Information System (INIS)

Grogg, André; Trippel, Mafalda; Pfaltz, Katrin; Lädrach, Claudia; Droeser, Raoul A.; Cihoric, Nikola; Salhia, Bodour; Zweifel, Martin; Tapia, Coya

2015-01-01

With the advent of new and more efficient anti-androgen drugs targeting androgen receptor (AR) in breast cancer (BC) is becoming an increasingly important area of investigation. This would potentially be most useful in triple negative BC (TNBC), where better therapies are still needed. The assessment of AR status is generally performed on the primary tumor even if the tumor has already metastasized. Very little is known regarding discrepancies of AR status during tumor progression. To determine the prevalence of AR positivity, with emphasis on TNBCs, and to investigate AR status during tumor progression, we evaluated a large series of primary BCs and matching metastases and recurrences. AR status was performed on 356 primary BCs, 135 matching metastases, and 12 recurrences using a next-generation Tissue Microarray (ngTMA). A commercially available AR antibody was used to determine AR-status by immunohistochemistry. AR positivity was defined as any nuclear staining in tumor cells ≥1 %. AR expression was correlated with pathological tumor features of the primary tumor. Additionally, the concordance rate of AR expression between the different tumor sites was determined. AR status was positive in: 87 % (307/353) of primary tumors, 86.1 % (105/122) of metastases, and in 66.7 % (8/12) of recurrences. TNBC tested positive in 11.4 %, (4/35) of BCs. A discrepant result was seen in 4.3 % (5/117) of primary BC and matching lymph node (LN) metastases. Three AR negative primary BCs were positive in the matching LN metastasis, representing 17.6 % of all negative BCs with lymph node metastases (3/17). Two AR positive primary BCs were negative in the matching LN metastasis, representing 2.0 % of all AR positive BCs with LN metastases (2/100). No discrepancies were seen between primary BC and distant metastases or recurrence (n = 17). Most primary (87 %) and metastasized (86.1 %) BCs are AR positive including a significant fraction of TNBCs (11.4 %). Further, AR status is highly

Progress and challenges of carbon nanotube membrane in water treatment

KAUST Repository

Lee, Jieun; Jeong, Sanghyun; Liu, Zongwen

2016-01-01

review of the progress of CNT membranes addressing the current epidemic—whether (i) the CNT membranes could tackle current challenges in the pressure- or thermally driven membrane processes and (ii) CNT hybrid nanocomposite as a new generation

Progress and Challenges in Implementing the Women, Peace and ...

African Journals Online (AJOL)

This article provides an initial overview of the African Union's progress and challenges ... peace initiatives to protect women and girls from gender-based violence. (GBV); to ... bilateral aid on gender equality to fragile states has quadrupled (UN. Women ..... (support of school supplies for ten children borne as a result of rape.

Implementing Environmental Management Accounting: Status and Challenges

DEFF Research Database (Denmark)

Cost Accounting - and its Interaction with Eco-Efficiency Performance Measurement and Indicators; Stefan Schaltegger and Marcus Wagner. 4. Environmental Accounting Dimensions: Pros and Cons of Trajectory Convergence and Increased Efficiency; Pontus Cerin and Staffan Laestadius. 5. Process and Content......Table of contents Preface. 1. Environmental Management Accounting: Innovation or Managerial Fad?; Pall Rikhardsson, Martin Bennett, Jan Jaap Bouma and Stefan Schaltegger. Section 1 Progress. 2. Challenges for Environmental Management Accounting; Roger L. Burritt 3. Current Trends in Environmental......: Visualizing the Policy Challenges of Environmental Management Accounting; Dick Osborn. Section 2 Exploring EMA implementation issues. 6. Environmental Performance and the Quality of Corporate Environmental Reports: The Role of Environmental Management Accounting; Marcus Wagner. 7. Environmental Risk...

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration.

Science.gov (United States)

Amanullah, Ayeman; Upadhyay, Arun; Joshi, Vibhuti; Mishra, Ribhav; Jana, Nihar Ranjan; Mishra, Amit

2017-12-01

Proteins are ordered useful cellular entities, required for normal health and organism's survival. The proteome is the absolute set of cellular expressed proteins, which regulates a wide range of physiological functions linked with all domains of life. In aging cells or under unfavorable cellular conditions, misfolding of proteins generates common pathological events linked with neurodegenerative diseases and aging. Current advances of proteome studies systematically generates some progress in our knowledge that how misfolding of proteins or their accumulation can contribute to the impairment or depletion of proteome functions. Still, the underlying causes of this unrecoverable loss are not clear that how such unsolved transitions give rise to multifactorial challengeable degenerative pathological conditions in neurodegeneration. In this review, we specifically focus and systematically summarize various molecular mechanisms of proteostasis maintenance, as well as discuss progressing neurobiological strategies, promising natural and pharmacological candidates, which can be useful to counteract the problem of proteopathies. Our article emphasizes an urgent need that now it is important for us to recognize the fundamentals of proteostasis to design a new molecular framework and fruitful strategies to uncover how the proteome defects are associated with aging and neurodegenerative diseases. A enhance understanding of progress link with proteome and neurobiological challenges may provide new basic concepts in the near future, based on pharmacological agents, linked with impaired proteostasis and neurodegenerative diseases. Copyright © 2017 Elsevier Ltd. All rights reserved.

Mental Status as a Predictor of Daily Function in Progressive Dementia.

Science.gov (United States)

Reed, Bruce R.; And Others

1989-01-01

Compared Mini Mental Status Exam (MMSE) scores and activities of daily living (ADL) scores from 59 patients with progressive dementias. MMSE scores explained approximately one-third of variance in both instrumental and physical ADLs. Findings suggest that cognitive losses and functional impairments are 2 distinct aspects of dementia severity which…

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1993-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

Energy Technology Data Exchange (ETDEWEB)

Till, C.E.; Chang, Y.I.

1993-03-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions.

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

Energy Technology Data Exchange (ETDEWEB)

Till, C.E.; Chang, Y.I.

1993-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions.

HTGR accident initiation and progression analysis status report. Volume VIII. Responses to comments on AIPA status report

Energy Technology Data Exchange (ETDEWEB)

Raabe, P.H.

1977-01-01

The first seven volumes of the report series provide formal documentation of the status of the ERDA-sponsored Accident Initiation and Progression Analysis (AIPA) study as of the end of FY75. That portion of the report was given broad distribution to government agencies, industrial organizations, and academic institutions. Comments on the Status Report have been actively solicited from these and other organizations. The volume presented (the eighth in the AIPA Status Report) documents all of the formal written comments that have been received as of September 30, 1976, together with the responses to those comments. The comments as presented are direct quotations from the manuscripts as submitted by the reviewers; none have been paraphrased. The comments are presented in the same order as submitted by the reviewers and are generally addressed individually.

HTGR accident initiation and progression analysis status report. Volume VIII. Responses to comments on AIPA status report

International Nuclear Information System (INIS)

Raabe, P.H.

1977-01-01

The first seven volumes of the report series provide formal documentation of the status of the ERDA-sponsored Accident Initiation and Progression Analysis (AIPA) study as of the end of FY75. That portion of the report was given broad distribution to government agencies, industrial organizations, and academic institutions. Comments on the Status Report have been actively solicited from these and other organizations. The volume presented (the eighth in the AIPA Status Report) documents all of the formal written comments that have been received as of September 30, 1976, together with the responses to those comments. The comments as presented are direct quotations from the manuscripts as submitted by the reviewers; none have been paraphrased. The comments are presented in the same order as submitted by the reviewers and are generally addressed individually

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1991-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. 10 refs

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

Energy Technology Data Exchange (ETDEWEB)

Till, C.E.; Chang, Y.I.

1991-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. 10 refs.

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1991-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. (author)

Overcoming Challenges to Childhood Immunizations Status.

Science.gov (United States)

Sabnis, Svapna S; Conway, James H

2015-10-01

Vaccines are one of the greatest public health achievements, preventing both mortality and morbidity. However, overall immunization rates are still below the 90% target for Healthy People 2020. There remain significant disparities in immunization rates between children of different racial/ethnic groups, as well as among economically disadvantaged populations. There are systemic issues and challenges in providing access to immunization opportunities. In addition, vaccine hesitancy contributes to underimmunization. Multiple strategies are needed to improve immunization rates, including improving access to vaccines and minimizing financial barriers to families. Vaccine status should be assessed and vaccines given at all possible opportunities. Copyright © 2015 Elsevier Inc. All rights reserved.

Nucleosynthesis in the early Galaxy: Progress and challenges.

Science.gov (United States)

Montes, Fernando

2015-10-01

Chemical imprints left by the first stars in the oldest stars of the Milky Way gives clues of the stellar nucleosynthesis responsible for the creation of elements heavier than iron. Recent progress in astronomical observations and in the modeling of the chemical evolution of the Galaxy have shown that multiple nucleosynthesis processes may operate at those early times. In this talk I will review some of that evidence along with the important role that nuclear reactions play in those processes. I will focus in progress in our understanding of the rapid neutron capture process (r-process) and in new results on nucleosynthesis in core-collapse supernovae and neutrino-driven winds that produce elements up to silver. I will show some examples of recent nuclear physics measurements addressing the need for better nuclear data and give an outlook of the remaining challenges and future plans to continue those measurements.

Achieving efficient RNAi therapy: progress and challenges

Directory of Open Access Journals (Sweden)

Kun Gao

2013-07-01

Full Text Available RNA interference (RNAi has been harnessed to produce a new class of drugs for treatment of various diseases. This review summarizes the most important parameters that govern the silencing efficiency and duration of the RNAi effect such as small interfering RNA (siRNA stability and modification, the type of delivery system and particle sizing methods. It also discusses the predominant barriers for siRNA delivery, such as off-target effects and introduces internalization, endosomal escape and mathematical modeling in RNAi therapy and combinatorial RNAi. At present, effective delivery of RNAi therapeutics in vivo remains a challenge although significant progress has been made in this field.

Hepatitis B Virus Infection in Tanzania: Current Status and Challenges

OpenAIRE

Kilonzo, Semvua B.; Gunda, Daniel W.; Mpondo, Bonaventura C. T.; Bakshi, Fatma A.; Jaka, Hyasinta

2018-01-01

Hepatitis B is one of the most common infectious diseases in the world with high prevalence in most of sub-Saharan Africa countries. The complexity in its diagnosis and treatment poses a significant management challenge in the resource-limited settings including Tanzania, where most of the tests and drugs are either unavailable or unaffordable. This mini review aims at demonstrating the current status of the disease in the country and discussing the concomitant challenges in diagnosis, treatm...

User Interfaces for Patient-Centered Communication of Health Status and Care Progress

Science.gov (United States)

Wilcox-Patterson, Lauren

2013-01-01

The recent trend toward patients participating in their own healthcare has opened up numerous opportunities for computing research. This dissertation focuses on how technology can foster this participation, through user interfaces to effectively communicate personal health status and care progress to hospital patients. I first characterize the…

Hepatitis B Virus Infection in Tanzania: Current Status and Challenges

Science.gov (United States)

Bakshi, Fatma A.; Jaka, Hyasinta

2018-01-01

Hepatitis B is one of the most common infectious diseases in the world with high prevalence in most of sub-Saharan Africa countries. The complexity in its diagnosis and treatment poses a significant management challenge in the resource-limited settings including Tanzania, where most of the tests and drugs are either unavailable or unaffordable. This mini review aims at demonstrating the current status of the disease in the country and discussing the concomitant challenges in diagnosis, treatment, and prevention. PMID:29666656

Hepatitis B Virus Infection in Tanzania: Current Status and Challenges

Directory of Open Access Journals (Sweden)

Semvua B. Kilonzo

2018-01-01

Full Text Available Hepatitis B is one of the most common infectious diseases in the world with high prevalence in most of sub-Saharan Africa countries. The complexity in its diagnosis and treatment poses a significant management challenge in the resource-limited settings including Tanzania, where most of the tests and drugs are either unavailable or unaffordable. This mini review aims at demonstrating the current status of the disease in the country and discussing the concomitant challenges in diagnosis, treatment, and prevention.

Integration of renewables. Status and challenges in China

Energy Technology Data Exchange (ETDEWEB)

Cheung, Kat

2011-08-12

This Working Paper gives an overview of the status and challenges of integrating an increasing share of variable renewables in China, with a focus on areas of generation, power transmission, demand-side management and policy. Some of these areas are intertwined with the nature and design of China's electricity power market and pricing mechanism, which have an impact on the effectiveness of the country's targets to accommodate larger shares of renewables.

Peptide Vaccine: Progress and Challenges

Directory of Open Access Journals (Sweden)

Weidang Li

2014-07-01

Full Text Available Conventional vaccine strategies have been highly efficacious for several decades in reducing mortality and morbidity due to infectious diseases. The bane of conventional vaccines, such as those that include whole organisms or large proteins, appear to be the inclusion of unnecessary antigenic load that, not only contributes little to the protective immune response, but complicates the situation by inducing allergenic and/or reactogenic responses. Peptide vaccines are an attractive alternative strategy that relies on usage of short peptide fragments to engineer the induction of highly targeted immune responses, consequently avoiding allergenic and/or reactogenic sequences. Conversely, peptide vaccines used in isolation are often weakly immunogenic and require particulate carriers for delivery and adjuvanting. In this article, we discuss the specific advantages and considerations in targeted induction of immune responses by peptide vaccines and progresses in the development of such vaccines against various diseases. Additionally, we also discuss the development of particulate carrier strategies and the inherent challenges with regard to safety when combining such technologies with peptide vaccines.

Cloud service performance evaluation: status, challenges, and opportunities – a survey from the system modeling perspective

Directory of Open Access Journals (Sweden)

Qiang Duan

2017-05-01

Full Text Available With rapid advancement of Cloud computing and networking technologies, a wide spectrum of Cloud services have been developed by various providers and utilized by numerous organizations as indispensable ingredients of their information systems. Cloud service performance has a significant impact on performance of the future information infrastructure. Thorough evaluation on Cloud service performance is crucial and beneficial to both service providers and consumers; thus forming an active research area. Some key technologies for Cloud computing, such as virtualization and the Service-Oriented Architecture (SOA, bring in special challenges to service performance evaluation. A tremendous amount of effort has been put by the research community to address these challenges and exciting progress has been made. Among the work on Cloud performance analysis, evaluation approaches developed with a system modeling perspective play an important role. However, related works have been reported in different sections of the literature; thus lacking a big picture that shows the latest status of this area. The objectives of this article is to present a survey that reflects the state of the art of Cloud service performance evaluation from the system modeling perspective. This articles also examines open issues and challenges to the surveyed evaluation approaches and identifies possible opportunities for future research in this important field.

ATLAS construction status

International Nuclear Information System (INIS)

Jenni, P.

2006-01-01

The ATLAS detector is being constructed at the LHC, in view of a data-taking startup in 2007. This report concentrates on the progress and the technical challenges of the detector construction, and summarizes the status of the work as of August 2004. The project is on track to allow the highly motivated ATLAS Collaboration to enter into a new exploratory domain of high-energy physics in 2007. (author)

The Abbott Districts in 2005-06: Progress and Challenges, Spring 2006

Science.gov (United States)

Hirsch, Lesley

2006-01-01

New Jersey's urban--or "Abbott"--schools have improved at the preschool and elementary school level, but lag when it comes to middle and high school performance. These are the key findings of an Abbott Indicators Project report entitled, "The Abbott Districts in 2005-06: Progress and Challenges." The report was prepared by…

Impedimetric biosensors for medical applications current progress and challenges

CERN Document Server

Rushworth, Jo V; Goode, Jack A; Pike, Douglas J; Ahmed, Asif; Millner, Paul

2014-01-01

In this monograph, the authors discuss the current progress in the medical application of impedimetric biosensors, along with the key challenges in the field. First, a general overview of biosensor development, structure and function is presented, followed by a detailed discussion of impedimetric biosensors and the principles of electrochemical impedance spectroscopy. Next, the current state-of-the art in terms of the science and technology underpinning impedance-based biosensors is reviewed in detail. The layer-by-layer construction of impedimetric sensors is described, including the design of electrodes, their nano-modification, transducer surface functionalization and the attachment of different bioreceptors. The current challenges of translating lab-based biosensor platforms into commercially-available devices that function with real patient samples at the POC are presented; this includes a consideration of systems integration, microfluidics and biosensor regeneration. The final section of this monograph ...

Emerging nanomedicine applications and manufacturing: progress and challenges.

Science.gov (United States)

Sartain, Felicity; Greco, Francesca; Hill, Kathryn; Rannard, Steve; Owen, Andrew

2016-03-01

APS 6th International PharmSci Conference 2015 7-9 September 2015 East Midlands Conference Centre, University of Nottingham, Nottingham, UK As part of the 6th APS International PharmSci Conference, a nanomedicine session was organised to address challenges and share experiences in this field. Topics ranged from the reporting on latest results and advances in the development of targeted therapeutics to the needs that the community faces in how to progress these exciting proof of concept results into products. Here we provide an overview of the discussion and highlight some of the initiatives that have recently been established to support the translation of nanomedicines into the clinic.

Human-Robot Interaction: Status and Challenges.

Science.gov (United States)

Sheridan, Thomas B

2016-06-01

The current status of human-robot interaction (HRI) is reviewed, and key current research challenges for the human factors community are described. Robots have evolved from continuous human-controlled master-slave servomechanisms for handling nuclear waste to a broad range of robots incorporating artificial intelligence for many applications and under human supervisory control. This mini-review describes HRI developments in four application areas and what are the challenges for human factors research. In addition to a plethora of research papers, evidence of success is manifest in live demonstrations of robot capability under various forms of human control. HRI is a rapidly evolving field. Specialized robots under human teleoperation have proven successful in hazardous environments and medical application, as have specialized telerobots under human supervisory control for space and repetitive industrial tasks. Research in areas of self-driving cars, intimate collaboration with humans in manipulation tasks, human control of humanoid robots for hazardous environments, and social interaction with robots is at initial stages. The efficacy of humanoid general-purpose robots has yet to be proven. HRI is now applied in almost all robot tasks, including manufacturing, space, aviation, undersea, surgery, rehabilitation, agriculture, education, package fetch and delivery, policing, and military operations. © 2016, Human Factors and Ergonomics Society.

Status of the RERTR program: overview, progress and plans

International Nuclear Information System (INIS)

Travelli, A.

1985-01-01

The status of the US Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a summary of the accomplishments which the RERTR Program had achieved by the end of 1984 with its many international partners, emphasis is placed on the progress achieved during 1985 and on current plans and schedules. A new miniplate series, concentrating on U 3 Si 2 -Al and U 3 Si-Al fuels, was fabricated and is well into irradiation. The whole-core ORR demonstration is scheduled to begin in November 1985, with U 3 Si 2 -Al fuel at 4.8 g U/cm 3 . Altogether, 921 full-size test and prototype elements have been ordered for fabrication with reduced enrichment and the new technologies. Qualification of U 3 Si-Al fuel with approx.7 g U/cm 3 is still projected for 1989. This progress could not have been achieved without the close international cooperation which has existed since the beginning, and whose continuation and intensification will be essential to the achievement of the long-term RERTR goals

Laser ignited engines: progress, challenges and prospects.

Science.gov (United States)

Dearden, Geoff; Shenton, Tom

2013-11-04

Laser ignition (LI) has been shown to offer many potential benefits compared to spark ignition (SI) for improving the performance of internal combustion (IC) engines. This paper outlines progress made in recent research on laser ignited IC engines, discusses the potential advantages and control opportunities and considers the challenges faced and prospects for its future implementation. An experimental research effort has been underway at the University of Liverpool (UoL) to extend the stratified speed/load operating region of the gasoline direct injection (GDI) engine through LI research, for which an overview of some of the approaches, testing and results to date are presented. These indicate how LI can be used to improve control of the engine for: leaner operation, reductions in emissions, lower idle speed and improved combustion stability.

U.S. Department of Energy Workplace Charging Challenge - Progress Update 2016: A New Sustainable Commute

Energy Technology Data Exchange (ETDEWEB)

2017-01-01

In June 2016, the Workplace Charging Challenge distributed its third annual survey to 295 partners with the goal of tracking partners' progress and identifying trends in workplace charging. This document summarizes findings from the survey and highlights accomplishments of the EV Everywhere Workplace Charging Challenge.

Protein Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma: Progress and Challenges.

Science.gov (United States)

Root, Alex; Allen, Peter; Tempst, Paul; Yu, Kenneth

2018-03-07

Approximately 75% of patients with pancreatic ductal adenocarcinoma are diagnosed with advanced cancer, which cannot be safely resected. The most commonly used biomarker CA19-9 has inadequate sensitivity and specificity for early detection, which we define as Stage I/II cancers. Therefore, progress in next-generation biomarkers is greatly needed. Recent reports have validated a number of biomarkers, including combination assays of proteins and DNA mutations; however, the history of translating promising biomarkers to clinical utility suggests that several major hurdles require careful consideration by the medical community. The first set of challenges involves nominating and verifying biomarkers. Candidate biomarkers need to discriminate disease from benign controls with high sensitivity and specificity for an intended use, which we describe as a two-tiered strategy of identifying and screening high-risk patients. Community-wide efforts to share samples, data, and analysis methods have been beneficial and progress meeting this challenge has been achieved. The second set of challenges is assay optimization and validating biomarkers. After initial candidate validation, assays need to be refined into accurate, cost-effective, highly reproducible, and multiplexed targeted panels and then validated in large cohorts. To move the most promising candidates forward, ideally, biomarker panels, head-to-head comparisons, meta-analysis, and assessment in independent data sets might mitigate risk of failure. Much more investment is needed to overcome these challenges. The third challenge is achieving clinical translation. To moonshot an early detection test to the clinic requires a large clinical trial and organizational, regulatory, and entrepreneurial know-how. Additional factors, such as imaging technologies, will likely need to improve concomitant with molecular biomarker development. The magnitude of the clinical translational challenge is uncertain, but interdisciplinary

Protein Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma: Progress and Challenges

Directory of Open Access Journals (Sweden)

Alex Root

2018-03-01

Full Text Available Approximately 75% of patients with pancreatic ductal adenocarcinoma are diagnosed with advanced cancer, which cannot be safely resected. The most commonly used biomarker CA19-9 has inadequate sensitivity and specificity for early detection, which we define as Stage I/II cancers. Therefore, progress in next-generation biomarkers is greatly needed. Recent reports have validated a number of biomarkers, including combination assays of proteins and DNA mutations; however, the history of translating promising biomarkers to clinical utility suggests that several major hurdles require careful consideration by the medical community. The first set of challenges involves nominating and verifying biomarkers. Candidate biomarkers need to discriminate disease from benign controls with high sensitivity and specificity for an intended use, which we describe as a two-tiered strategy of identifying and screening high-risk patients. Community-wide efforts to share samples, data, and analysis methods have been beneficial and progress meeting this challenge has been achieved. The second set of challenges is assay optimization and validating biomarkers. After initial candidate validation, assays need to be refined into accurate, cost-effective, highly reproducible, and multiplexed targeted panels and then validated in large cohorts. To move the most promising candidates forward, ideally, biomarker panels, head-to-head comparisons, meta-analysis, and assessment in independent data sets might mitigate risk of failure. Much more investment is needed to overcome these challenges. The third challenge is achieving clinical translation. To moonshot an early detection test to the clinic requires a large clinical trial and organizational, regulatory, and entrepreneurial know-how. Additional factors, such as imaging technologies, will likely need to improve concomitant with molecular biomarker development. The magnitude of the clinical translational challenge is uncertain, but

Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges.

Science.gov (United States)

Pfeiffer, Christine M; Looker, Anne C

2017-12-01

Biochemical assessment of iron status relies on serum-based indicators, such as serum ferritin (SF), transferrin saturation, and soluble transferrin receptor (sTfR), as well as erythrocyte protoporphyrin. These indicators present challenges for clinical practice and national nutrition surveys, and often iron status interpretation is based on the combination of several indicators. The diagnosis of iron deficiency (ID) through SF concentration, the most commonly used indicator, is complicated by concomitant inflammation. sTfR concentration is an indicator of functional ID that is not an acute-phase reactant, but challenges in its interpretation arise because of the lack of assay standardization, common reference ranges, and common cutoffs. It is unclear which indicators are best suited to assess excess iron status. The value of hepcidin, non-transferrin-bound iron, and reticulocyte indexes is being explored in research settings. Serum-based indicators are generally measured on fully automated clinical analyzers available in most hospitals. Although international reference materials have been available for years, the standardization of immunoassays is complicated by the heterogeneity of antibodies used and the absence of physicochemical reference methods to establish "true" concentrations. From 1988 to 2006, the assessment of iron status in NHANES was based on the multi-indicator ferritin model. However, the model did not indicate the severity of ID and produced categorical estimates. More recently, iron status assessment in NHANES has used the total body iron stores (TBI) model, in which the log ratio of sTfR to SF is assessed. Together, sTfR and SF concentrations cover the full range of iron status. The TBI model better predicts the absence of bone marrow iron than SF concentration alone, and TBI can be analyzed as a continuous variable. Additional consideration of methodologies, interpretation of indicators, and analytic standardization is important for further

Health impact assessment in China: Emergence, progress and challenges

Energy Technology Data Exchange (ETDEWEB)

Huang Zheng, E-mail: huangzhg@mails.tjmu.edu.cn

2012-01-15

The values, concepts and approaches of health impact assessment (HIA) were outlined in the Gothenburg consensus paper and some industrialized countries have implemented HIA for many years. HIA has played an important role in environmental protection in China, however, the emergence, progress and challenges of HIA in China have not been well described. In this paper, the evolution of HIA in China was analyzed and the challenges of HIA were presented based on the author's experiences. HIA contributed to decision-making for large capital construction projects, such as the Three Gorges Dam project, in its emergence stage. Increasing attention has been given to HIA in recent years due to supportive policies underpinning development of the draft HIA guidelines in 2008. However enormous challenges lie ahead in ensuring the institutionalization of HIA into project, program and policy decision-making process due to limited scope, immature tools and insufficient professionals in HIA practice. HIA should broaden its horizons by encompassing physical, chemical, biological and socio-economic aspects and constant attempts should be made to integrate HIA into the decision-making process, not only for projects and programs but also for policies as well.

Status of Progress Made Toward Preliminary Design Concepts for the Inventory in Select Media for DOE-Managed HLW/SNF

Energy Technology Data Exchange (ETDEWEB)

Matteo, Edward N. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hardin, Ernest L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hadgu, Teklu [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Park, Heeho Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rigali, Mark J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jove-Colon, Carlos F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-09-30

As the title suggests, this report provides a summary of the status and progress for the Preliminary Design Concepts Work Package. Described herein are design concepts and thermal analysis for crystalline and salt host media. The report concludes that thermal management of defense waste, including the relatively small subset of high thermal output waste packages, is readily achievable. Another important conclusion pertains to engineering feasibility, and design concepts presented herein are based upon established and existing elements and/or designs. The multipack configuration options for the crystalline host media pose the greatest engineering challenges, as these designs involve large, heavy waste packages that pose specific challenges with respect to handling and emplacement. Defense-related Spent Nuclear Fuel (DSNF) presents issues for post-closure criticality control, and a key recommendation made herein relates to the need for special packaging design that includes neutron-absorbing material for the DSNF. Lastly, this report finds that the preliminary design options discussed are tenable for operational and post-closure safety, owing to the fact that these concepts have been derived from other published and well-studied repository designs.

Silicon spintronics: Progress and challenges

Energy Technology Data Exchange (ETDEWEB)

Sverdlov, Viktor; Selberherr, Siegfried, E-mail: Selberherr@TUWien.ac.at

2015-07-14

Electron spin attracts much attention as an alternative to the electron charge degree of freedom for low-power reprogrammable logic and non-volatile memory applications. Silicon appears to be the perfect material for spin-driven applications. Recent progress and challenges regarding spin-based devices are reviewed. An order of magnitude enhancement of the electron spin lifetime in silicon thin films by shear strain is predicted and its impact on spin transport in SpinFETs is discussed. A relatively weak coupling between spin and effective electric field in silicon allows magnetoresistance modulation at room temperature, however, for long channel lengths. Due to tunneling magnetoresistance and spin transfer torque effects, a much stronger coupling between the spin (magnetization) orientation and charge current is achieved in magnetic tunnel junctions. Magnetic random access memory (MRAM) built on magnetic tunnel junctions is CMOS compatible and possesses all properties needed for future universal memory. Designs of spin-based non-volatile MRAM cells are presented. By means of micromagnetic simulations it is demonstrated that a substantial reduction of the switching time can be achieved. Finally, it is shown that any two arbitrary memory cells from an MRAM array can be used to perform a logic operation. Thus, an intrinsic non-volatile logic-in-memory architecture can be realized.

Silicon spintronics: Progress and challenges

International Nuclear Information System (INIS)

Sverdlov, Viktor; Selberherr, Siegfried

2015-01-01

Electron spin attracts much attention as an alternative to the electron charge degree of freedom for low-power reprogrammable logic and non-volatile memory applications. Silicon appears to be the perfect material for spin-driven applications. Recent progress and challenges regarding spin-based devices are reviewed. An order of magnitude enhancement of the electron spin lifetime in silicon thin films by shear strain is predicted and its impact on spin transport in SpinFETs is discussed. A relatively weak coupling between spin and effective electric field in silicon allows magnetoresistance modulation at room temperature, however, for long channel lengths. Due to tunneling magnetoresistance and spin transfer torque effects, a much stronger coupling between the spin (magnetization) orientation and charge current is achieved in magnetic tunnel junctions. Magnetic random access memory (MRAM) built on magnetic tunnel junctions is CMOS compatible and possesses all properties needed for future universal memory. Designs of spin-based non-volatile MRAM cells are presented. By means of micromagnetic simulations it is demonstrated that a substantial reduction of the switching time can be achieved. Finally, it is shown that any two arbitrary memory cells from an MRAM array can be used to perform a logic operation. Thus, an intrinsic non-volatile logic-in-memory architecture can be realized

Smart garments in chronic disease management: progress and challenges

Science.gov (United States)

Khosla, Ajit

2012-10-01

This paper presents the progress made developments in the area of Smart Garments for chronic disease management over last 10 years. A large number of health monitoring smart garments and wearable sensors have been manufactured to monitor patient's physiological parameters such as electrocardiogram, blood pressure, body temperature, heart rate, oxygen saturation, while patient is not in hospital. In last few years with the advancement in smartphones and cloud computing it is now possible to send the measure physiological data to any desired location. However there are many challenges in the development of smart garment systems. The two major challenges are development of new lightweight power sources and there is a need for global standardization and a road map for development of smart garments. In this paper we will discuss current state-of-theart smart garments and wearable sensor systems. Also discussed will be the new emerging trends in smart garment research and development.

QCD and strongly coupled gauge theories: challenges and perspectives

NARCIS (Netherlands)

Brambilla, N.; Eidelman, S.; Foka, P.; Gardner, S.; Kronfeld, A. S.; Alford, M. G.; Alkofer, R.; Butenschoen, M.; Cohen, T. D.; Erdmenger, J.; Fabbietti, L.; Faber, M.; Goity, J. L.; Ketzer, B.; Lin, H. W.; Llanes-Estrada, F. J.; Meyer, H.; Pakhlov, P.; Pallante, E.; Polikarpov, M. I.; Sazdjian, H.; Schmitt, A.; Snow, W. M.; Vairo, A.; Vogt, R.; Vuorinen, A.; Wittig, H.; Arnold, P.; Christakoglou, P.; Nezza, P. Di; Fodor, Z.; Tormo, X. Garcia i; Höllwieser, R.; Kalwait, A.; Keane, D.; Kiritsis, E.; Mischke, A.; Mizuk, R.; Odyniec, G.; Papadodimas, K.; Pich, A.; Pittau, R.; Qiu, Jian-Wei; Ricciardi, G.; Salgado, C. A.; Schwenzer, K.; Stefanis, N. G.; Hippel, G. M. von; Zakharov, V. I .

2014-01-01

We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly-coupled, complex

Status and challenges for radioactive waste management

International Nuclear Information System (INIS)

Riotte, H.

2011-01-01

In its 2008 Nuclear Energy Outlook the NEA reviewed the status of radioactive waste management world-wide and noted that the technology for disposal of short-lived low- and intermediate-level radioactive waste is well developed. The review concluded that all OECD countries with major nuclear programmes either operate corresponding waste disposal facilities or are in an advanced stage of developing them. By contrast, the developmental progress of HLW/SNF management programmes varies widely between countries; not to mention that there is currently no repository operating that could take spent nuclear fuel or high-level waste from reprocessing. In its collective opinion 'Moving forward with geological disposal' the NEA noted that deep underground disposal in geological formations is seen worldwide as the only sustainable endpoint for the management of these types of waste, as it affords unparalleled protection without reliance on active safety monitoring and controls. While waste management programmes in some countries are well matured and countries like Finland, France and Sweden aim to operate geologic repositories in the next decade, others need to develop their national strategies, plans and corresponding actions for managing radioactive waste further. Periodically reviewed national waste management plans, as legally required for EU member countries by a recent Directive, can provide a co-operation framework for all national institutional players and a means to measure progress. In implementing sustainable solutions for the long-term management of HLW/SNF, specific challenges lay in establishing an efficient policy and regulatory framework that (a) defines a desired level of safety over the various time scales to be considered and (b) allows for sustainable decision making procedures by involving public and stakeholder in a flexible, step-wise implementation process. Technical confidence in the safety of a repository needs to be demonstrated in a modern

Rethinking the relationship between socioeconomic status and health: Challenging how socioeconomic status is currently used in health inequality research.

Science.gov (United States)

Gagné, Thierry; Ghenadenik, Adrian E

2018-02-01

The Scandinavian Journal of Public Health recently reiterated the importance of addressing social justice and health inequalities in its new editorial policy announcement. One of the related challenges highlighted in that issue was the limited use of sociological theories able to inform the complexity linking the resources and mechanisms captured by the concept of socioeconomic status. This debate article argues that part of the problem lies in the often unchallenged reliance on a generic conceptualization and operationalization of socioeconomic status. These practices hinder researchers' capacity to examine in finer detail how resources and circumstances promote the unequal distribution of health through distinct yet intertwined pathways. As a potential way forward, this commentary explores how research practices can be challenged through concrete publication policies and guidelines. To this end, we propose a set of recommendations as a tool to strengthen the study of socioeconomic status and, ultimately, the quality of health inequality research. Authors, reviewers, and editors can become champions of change toward the implementation of sociological theory by holding higher standards regarding the conceptualization, operationalization, analysis, and interpretation of results in health inequality research.

The U.S. RERTR program status and progress

International Nuclear Information System (INIS)

Travelli, A.

1998-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program since its inception in 1978 is described. A brief summary of the results which the RERTR Program had achieved by the end of 1996 in collaboration with its many international partners is followed by a detailed review of the major events, findings, and activities of 1997. Significant progress has been made during the past year. In the area of U.S. acceptance of spent fuel from foreign research reactors, several shipments have taken place and additional are being planned. Intense fuel development activities are in progress, including procurement of equipment, screening of candidate materials, and production of microplates. Irradiation of the first series of microplates began in August 1997 in the Advanced Test Reactor, in Idaho. Progress has been made in the Russian RERTR program, which aims to develop and demonstrate within five years the technical means needed to convert Russian-supplied research reactors to LEU fuels. The study of an alternative LEU core for the FRM-II design has been extended to address, with favorable results, controversial performance issues which were raised at last year's meeting. Progress was also made on several aspects of producing molybdenum-99 from fission targets utilizing LEU instead of HEU. Various types of targets and processes are being pursued, with FDA approval of an LEU process projected to occur within two years. The feasibility of LEU Fuel conversion for three important DOE research reactors (BMRR, HFBR, and HFIR) has been evaluated by the RERTR program. In spite of the many momentous events which have occurred during the intervening years, and the excellent progress achieved, the most important challenges that the RERTR program faces today are not very different in type from those that were faced during the first RERTR meeting. Now, as then, the most important task is to develop new LEU fuels satisfying requirements which cannot be satisfied by any

The U.S. RERTR Program. Status and progress

International Nuclear Information System (INIS)

Travelli, A.

1997-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program since its inception in 1978 is described. A brief summary of the results which the RERTR Program had achieved by the end of 1996 in collaboration with its many international partners is followed by a detailed review of the major events, findings, and activities of 1997. Significant progress has been made during the past year. In the area of U.S. acceptance of spent fuel from foreign research reactors, several shipments have taken place and additional are being planned. Intense fuel development activities are in progress, including procurement of equipment, screening of candidate materials, and production of microplates. Irradiation of the first series of microplates began in August 1997 in the Advanced Test Reactor, in Idaho. Progress has been made in the Russian RERTR program, which aims to develop and demonstrate within five years the technical means needed to convert Russian-supplied research reactors to LEU fuels. The study of an alternative LEU core for the FRM-II design has been extended to address, with favorable results, controversial performance issues which were raised at last year's meeting. Progress was also made on several aspects of producing molybdenum-99 from fission targets utilizing LEU instead of HEU. Various types of targets and processes are being pursued, with FDA approval of an LEU process projected to occur within two years. The feasibility of LEU fuel conversion for three important DOE research reactors (BMRR, HFBR, and HFIR) has been evaluated by the RERTR program. In spite of the many momentous events which have occurred during the intervening years, and the excellent progress achieved, the most important challenges that the RERTR program faces today are not very different in type from those that were faced during the first RERTR meeting. Now, as then, the most important task is to develop new LEU fuels satisfying requirements which cannot be satisfied by any

CLARIN-DK – status and challenges

DEFF Research Database (Denmark)

Offersgaard, Lene; Jongejan, Bart; Hansen, Dorte Haltrup

2013-01-01

, multimodal resources and tools, and involving users is a core issue. Users involved in a preparatory project gave input that led to the current user interface of the resource repository website, clarin.dk. Clarin.dk is now in the transition phase from a repository to a research infrastructure, where...... researchers and students can be supported in their research, education and studies. Clarin.dk works with a Service-Oriented Architecture (SOA), uses eSciDoc and Fedora Commons, and is primarily based on open source solutions. A key issue in CLARIN-DK is using standards such as TEIP5, IMDI, OLAC, and CMDI......The initiative CLARIN-DK (starting as a Danish preparatory DK-CLARIN project) is a part of the Danish research infrastructure initiative, DIGHUMLAB. In this paper the aims, status, and the current challenges for CLARIN-DK are presented. CLARIN-DK focuses on written and spoken language resources...

Russian section of GGOS: Network status and progress

Directory of Open Access Journals (Sweden)

A. Ipatov

2017-03-01

Full Text Available Establishment of the Russian section in the framework of Global Geodetic Observing System (GGOS is under progress. New components of “Quasar” network observatories, which are included into GGOS global network as core stations, are presented. Recent developments include: two new generation radio telescopes with 13 m antennas at Badary and Zelenchukskaya observatories, water vapor radiometers installed at all observatories and software correlator at the Institute of Applied Astronomy. New and potential developments within other networks belonging to different agencies are also considered in the context of widening of Russian section activity in GGOS project. The paper gives a short overview of status, new components and plans, concerning 5 sub-networks of Federal Agency of Scientific Organizations, Roskosmos, Rosstandard, and Rosreestr. Short overview of the plans on creating Data and Analysis Distributed Center is also given.

76 FR 4342 - Adequacy Status of the Houston-Galveston-Brazoria, Texas Reasonable Further Progress and...

Science.gov (United States)

2011-01-25

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9256-8] Adequacy Status of the Houston-Galveston-Brazoria... vehicle emissions budgets (MVEBs) in the Houston-Galveston-Brazoria, Texas (HGB) Reasonable Further... Progress (RFP) SIP and an Attainment Demonstration SIP for the Houston- Galveston-Brazoria (HGB) ozone...

Nuclear Data Covariances in the Indian Context – Progress, Challenges, Excitement and Perspectives

International Nuclear Information System (INIS)

Ganesan, S.

2015-01-01

We present a brief overview of progress, challenges, excitement and perspectives in developing nuclear data covariances in the Indian context in relation to target accuracies and sensitivity studies that are of great importance to Bhabha's 3-stage nuclear programme for energy and non-energy applications

Progress and challenges associated with halal authentication of consumer packaged goods.

Science.gov (United States)

Premanandh, Jagadeesan; Bin Salem, Samara

2017-11-01

Abusive business practices are increasingly evident in consumer packaged goods. Although consumers have the right to protect themselves against such practices, rapid urbanization and industrialization result in greater distances between producers and consumers, raising serious concerns on the supply chain. The operational complexities surrounding halal authentication pose serious challenges on the integrity of consumer packaged goods. This article attempts to address the progress and challenges associated with halal authentication. Advancement and concerns on the application of new, rapid analytical methods for halal authentication are discussed. The significance of zero tolerance policy in consumer packaged foods and its impact on analytical testing are presented. The role of halal assurance systems and their challenges are also considered. In conclusion, consensus on the establishment of one standard approach coupled with a sound traceability system and constant monitoring would certainly improve and ensure halalness of consumer packaged goods. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Status and challenges of residential and industrial non-intrusive load monitoring

DEFF Research Database (Denmark)

Adabi, Ali; Mantey, Patrick; Holmegaard, Emil

2015-01-01

in recent years due to improvement in algorithms and methodologies. Currently, the important challenges facing residential NILM are inaccessibility of electricity meter high sampling data, and lack of reliable high resolution datasets. For industrial NILM the identification is more challenging due......Non-Intrusive Load Monitoring (NILM) is the process of identification of loads from an aggregate power interface using disaggregation algorithms. This paper identifies the current status, methodologies and challenges of NILM in residential and industrial settings. NILM has advanced substantially...... to increased number of loads and the variability of equipment type, temporal patterns and industrial secrecy. From our examination of data and its use in NILM, we observe that the number of devices that can be recognized and the training period required to achiever recognition is not only a function...

The status of the RERTR Program: Overview, progress and plans

International Nuclear Information System (INIS)

Travelli, A.

1985-01-01

The status of the U.S. Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a summary of the accomplishments which the RERTR Program had achieved by the end of 1984 with its many international partners, emphasis is placed on the progress achieved during 1985 and on current plans and schedules. A new miniplate series, concentrating on U 3 Si 2 -AI and U 3 Si-AI fuels, was fabricated and is well into irradiation. The whole-core ORR demonstration is scheduled to begin in November 1985, with U 3 Si 2 -AI fuel at 4.8 g U/cm 3 . Altogether, 921 full-size test and prototype elements have been ordered for fabrication with reduced enrichment and the new technologies. Qualification of U 3 Si-AI fuel with ∼7 g U/cm 3 is still projected for 1989. This progress could not have been achieved without the close international cooperation which has existed since the beginning, and whose continuation and intensification will be essential to the achievement of the long-term RERTR goals. (author)

The FCC-ee study: Progress and challenges

CERN Document Server

Koratzinos, Michael; Bogomyagkov, Anton; Boscolo, Manuela; Cook, Charlie; Doblhammer, Andreas; Härer, Bastian; Tomás, Rogelio; Levichev, Evgeny; Medina Medrano, Luis; Shatilov, Dmitry; Wienands, Ulrich; Zimmermann, Frank

The FCC (Future Circular Collider) study represents a vision for the next large project in high energy physics, comprising an 80-100 km tunnel that can house a future 100 TeV hadron collider. The study also includes a high luminosity e+e- collider operating in the centre-of-mass energy range of 90-350 GeV as a possible intermediate step, the FCC-ee. The FCC-ee aims at definitive electro-weak precision measurements of the Z, W, H and top particles, and search for rare phenomena. Although FCC-ee is based on known technology, the goal performance in luminosity and energy calibration make it quite challenging. During 2014 the study went through an exploration phase. The study has now entered its second year and the aim is to produce a conceptual design report during the next three to four years. We here report on progress since the last IPAC conference.

Advanced teaching labs in physics - celebrating progress; challenges ahead

Science.gov (United States)

Peterson, Richard

A few examples of optical physics experiments may help us first reflect on significant progress on how advanced lab initiatives may now be more effectively developed, discussed, and disseminated - as opposed to only 10 or 15 years back. Many cooperative developments of the last decade are having profound impacts on advanced lab workers and students. Central to these changes are the programs of the Advanced Laboratory Physics Association (ALPhA) (Immersions, BFY conferences), AAPT (advlab-l server, ComPADRE, apparatus competitions, summer workshops/sessions), APS (Reichert Award, FEd activities and sessions), and the Jonathan F. Reichert Foundation (ALPhA support and institution matched equipment grants for Immersion participants). Broad NSF support has helped undergird several of these initiatives. Two of the most significant challenges before this new advanced lab community are (a) to somehow enhance funding opportunities for teaching equipment and apparatus in an era of minimal NSF equipment support, and (b) to help develop a more complementary relationship between research-based advanced lab pedagogies and the development of fresh physics experiments that help enable the mentoring and experimental challenge of our students.

78 FR 46947 - Adequacy Status of the Houston-Galveston-Brazoria, Texas Reasonable Further Progress and...

Science.gov (United States)

2013-08-02

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9841-2] Adequacy Status of the Houston-Galveston-Brazoria... has found that the motor vehicle emissions budgets (MVEBs) in the Houston-Galveston-Brazoria, Texas... 2: Table 1-- Houston-Galveston-Brazoria 1997 8-Hour Ozone Reasonable Further Progress NOX and VOC...

Fuel Cell Buses in U.S. Transit Fleets: Current Status 2011

Science.gov (United States)

2011-11-11

his report is the fifth in a series of annual status reports that summarize the progress resulting from fuel cell transit bus demonstrations in the United States and provide a discussion of the achievements and challenges of fuel cell propulsion in t...

Current status, future opportunities, and remaining challenges in landscape genetics [Chapter 14

Science.gov (United States)

Niko Balkenhol; Samuel A. Cushman; Lisette P. Waits; Andrew Storfer

2016-01-01

Landscape genetics has advanced the field of evolutionary ecology by providing a direct focus on relationships between landscape patterns and population processes, such as gene flow, selection, and genetic drift. This chapter discusses the current and emerging challenges and opportunities, which focus and facilitate future progress in the field. It presents ten...

Status and Recent Progress in Photovoltaic Manufacturing in the USA

Energy Technology Data Exchange (ETDEWEB)

Witt, C.E.

2001-01-12

This paper describes the present status of photovoltaic technology and recent manufacturing progress obtained through the US Department of Energy's Photovoltaic Manufacturing Technology Project (PVMaT). Although barriers to the widespread use of photovoltaics--a clean and renewable energy--continue to exist, many of these barriers are cost-related and can be addressed through further research on existing approaches. Important areas for development are new materials, improved manufacturing processes, more efficient conversion of sunlight to electricity, and ensured long-term reliability. Improvements in these areas can be expected to lead to lowering of system costs and, ultimately, of energy cost. Specific improvements in manufacturing processes by individual PVMaT participants are described.

Facility status and progress of the INEL's WERF MLLW and LLW incinerator

International Nuclear Information System (INIS)

Conley, D.; Corrigan, S.

1996-01-01

The Idaho National Engineering Laboratory's (INEL) Waste Experimental Reduction Facility (WERF) incinerator began processing beta/gamma- emitting low-level waste (LLW) in September 1984. A Resource Conservation and Recovery Act (RCRA) trial burn for the WERF incinerator was conducted in 1986, and in 1989 WERF began processing (hazardous and low-level radioactive) waste known as mixed low-level waste (MLLW). On February 14, 1991 WERF operations were suspended to improve operating procedures and configuration management. On July 12, 1995, WERF initiated incineration of LLW; and on September 20, 1995 WERF resumed its primary mission of incinerating MLLW. MLLW incineration is proceeding under RCRA interim status. State of Idaho issuance of the Part B permit is one of the State's highest permitting priorities. The State of Idaho's Division of Environmental Quality is reviewing the permit application along with a revised trial burn plan that was also submitted with the application. The trial burn has been proposed to be performed in 1996 to demonstrate compliance with the current incinerator guidance. This paper describes the experiences and problems associated with WERF's operations, incineration of MLLW, and the RCRA Part B Permit Application. Some of the challenges that have been overcome include waste characterization, waste repackaging, repackaged waste storage, and implementation of RCRA interim status requirements. A number of challenges remain. They include revision of the RCRA Part B Permit Application and the Trial Burn Plan in response to comments from the state permit application reviewers as well as facility and equipment upgrades required to meet RCRA Permitted Status

Accident tolerant fuel cladding development: Promise, status, and challenges

Science.gov (United States)

Terrani, Kurt A.

2018-04-01

The motivation for transitioning away from zirconium-based fuel cladding in light water reactors to significantly more oxidation-resistant materials, thereby enhancing safety margins during severe accidents, is laid out. A review of the development status for three accident tolerant fuel cladding technologies, namely coated zirconium-based cladding, ferritic alumina-forming alloy cladding, and silicon carbide fiber-reinforced silicon carbide matrix composite cladding, is offered. Technical challenges and data gaps for each of these cladding technologies are highlighted. Full development towards commercial deployment of these technologies is identified as a high priority for the nuclear industry.

Challenges with Final Status Surveys at a Large Decommissioning Site - 13417

International Nuclear Information System (INIS)

Downey, Heath; Collopy, Peter; Shephard, Eugene; Walter, Nelson; Conant, John

2013-01-01

As part of decommissioning a former nuclear fuel manufacturing site, one of the crucial final steps is to conduct Final Status Surveys (FSS) in order to demonstrate compliance with the release criteria. At this decommissioning site, the area for FSS was about 100 hectares (248 acres) and included varying terrain, wooded areas, ponds, excavations, buildings and a brook. The challenges in performing the FSS included determining location, identifying FSS units, logging gamma walkover survey data, determining sample locations, managing water in excavations, and diverting water in the brook. The approaches taken to overcome these challenges will be presented in the paper. The paper will present and discuss lessons learned that will aid others in the FSS process. (authors)

Gaucher disease: Progress and ongoing challenges.

Science.gov (United States)

Mistry, Pramod K; Lopez, Grisel; Schiffmann, Raphael; Barton, Norman W; Weinreb, Neal J; Sidransky, Ellen

Over the past decades, tremendous progress has been made in the field of Gaucher disease, the inherited deficiency of the lysosomal enzyme glucocerebrosidase. Many of the colossal achievements took place during the course of the sixty-year tenure of Dr. Roscoe Brady at the National Institutes of Health. These include the recognition of the enzymatic defect involved, the isolation and characterization of the protein, the localization and characterization of the gene and its nearby pseudogene, as well as the identification of the first mutant alleles in patients. The first treatment for Gaucher disease, enzyme replacement therapy, was conceived of, developed and tested at the Clinical Center of the National Institutes of Health. Advances including recombinant production of the enzyme, the development of mouse models, pioneering gene therapy experiments, high throughput screens of small molecules and the generation of induced pluripotent stem cell models have all helped to catapult research in Gaucher disease into the twenty-first century. The appreciation that mutations in the glucocerebrosidase gene are an important risk factor for parkinsonism further expands the impact of this work. However, major challenges still remain, some of which are described here, that will provide opportunities, excitement and discovery for the next generations of Gaucher investigators. Published by Elsevier Inc.

PIP-II Injector Test: Challenges and Status

Energy Technology Data Exchange (ETDEWEB)

Derwent, P. F. [Fermilab; Carneiro, J. P. [Fermilab; Edelen, J. [Fermilab; Lebedev, V. [Fermilab; Prost, L. [Fermilab; Saini, A. [Fermilab; Shemyakin, A. [Fermilab; Steimel, J. [Fermilab

2016-10-04

The Proton Improvement Plan II (PIP-II) at Fermilab is a program of upgrades to the injection complex. At its core is the design and construction of a CW-compatible, pulsed H- superconducting RF linac. To validate the concept of the front-end of such machine, a test accelerator known as PIP-II Injector Test is under construction. It includes a 10mA DC, 30 keV H- ion source, a 2 m-long Low Energy Beam Transport (LEBT), a 2.1 MeV CW RFQ, followed by a Medium Energy Beam Transport (MEBT) that feeds the first of 2 cryomodules increasing the beam energy to about 25 MeV, and a High Energy Beam Transport section (HEBT) that takes the beam to a dump. The ion source, LEBT, RFQ, and initial version of the MEBT have been built, installed, and commissioned. This report presents the overall status of the Injector Test warm front end, including results of the beam commissioning through the installed components, and progress with SRF cryomodules and other systems.

Progress and Challenges in Assessing NOAA Data Management

Science.gov (United States)

de la Beaujardiere, J.

2016-12-01

The US National Oceanic and Atmospheric Administration (NOAA) produces large volumes of environmental data from a great variety of observing systems including satellites, radars, aircraft, ships, buoys, and other platforms. These data are irreplaceable assets that must be properly managed to ensure they are discoverable, accessible, usable, and preserved. A policy framework has been established which informs data producers of their responsibilities and which supports White House-level mandates such as the Executive Order on Open Data and the OSTP Memorandum on Increasing Access to the Results of Federally Funded Scientific Research. However, assessing the current state and progress toward completion for the many NOAA datasets is a challenge. This presentation will discuss work toward establishing assessment methodologies and dashboard-style displays. Ideally, metrics would be gathered though software and be automatically updated whenever an individual improvement was made. In practice, however, some level of manual information collection is required. Differing approaches to dataset granularity in different branches of NOAA yield additional complexity.

Conference Scene: From innovative polymers to advanced nanomedicine: Key challenges, recent progress and future perspectives

NARCIS (Netherlands)

Feijen, Jan; Hennink, W.E.; Zhong, Zhiyuan

2013-01-01

Recent developments in polymer-based controlled delivery systems have made a significant clinical impact. The second Symposium on Innovative Polymers for Controlled Delivery (SIPCD) was held in Suzhou, China to address the key challenges and provide up-to-date progress and future perspectives in the

Tissue Engineering of Blood Vessels: Functional Requirements, Progress, and Future Challenges.

Science.gov (United States)

Kumar, Vivek A; Brewster, Luke P; Caves, Jeffrey M; Chaikof, Elliot L

2011-09-01

Vascular disease results in the decreased utility and decreased availability of autologus vascular tissue for small diameter (requires combined approaches from biomaterials science, cell biology, and translational medicine to develop feasible solutions with the requisite mechanical support, a non-fouling surface for blood flow, and tissue regeneration. Over the past two decades interest in blood vessel tissue engineering has soared on a global scale, resulting in the first clinical implants of multiple technologies, steady progress with several other systems, and critical lessons-learned. This review will highlight the current inadequacies of autologus and synthetic grafts, the engineering requirements for implantation of tissue-engineered grafts, and the current status of tissue-engineered blood vessel research.

PROGRESS & CHALLENGES IN CLEANUP OF HANFORDS TANK WASTES

Energy Technology Data Exchange (ETDEWEB)

HEWITT, W.M.; SCHEPENS, R.

2006-01-23

The River Protection Project (RPP), which is managed by the Department of Energy (DOE) Office of River Protection (ORP), is highly complex from technical, regulatory, legal, political, and logistical perspectives and is the largest ongoing environmental cleanup project in the world. Over the past three years, ORP has made significant advances in its planning and execution of the cleanup of the Hartford tank wastes. The 149 single-shell tanks (SSTs), 28 double-shell tanks (DSTs), and 60 miscellaneous underground storage tanks (MUSTs) at Hanford contain approximately 200,000 m{sup 3} (53 million gallons) of mixed radioactive wastes, some of which dates back to the first days of the Manhattan Project. The plan for treating and disposing of the waste stored in large underground tanks is to: (1) retrieve the waste, (2) treat the waste to separate it into high-level (sludge) and low-activity (supernatant) fractions, (3) remove key radionuclides (e.g., Cs-137, Sr-90, actinides) from the low-activity fraction to the maximum extent technically and economically practical, (4) immobilize both the high-level and low-activity waste fractions by vitrification, (5) interim store the high-level waste fraction for ultimate disposal off-site at the federal HLW repository, (6) dispose the low-activity fraction on-site in the Integrated Disposal Facility (IDF), and (7) close the waste management areas consisting of tanks, ancillary equipment, soils, and facilities. Design and construction of the Waste Treatment and Immobilization Plant (WTP), the cornerstone of the RPP, has progressed substantially despite challenges arising from new seismic information for the WTP site. We have looked closely at the waste and aligned our treatment and disposal approaches with the waste characteristics. For example, approximately 11,000 m{sup 3} (2-3 million gallons) of metal sludges in twenty tanks were not created during spent nuclear fuel reprocessing and have low fission product concentrations. We

Controlling the HIV/AIDS epidemic: current status and global challenges

Directory of Open Access Journals (Sweden)

Thorsten eDemberg

2012-08-01

Full Text Available This review provides an overview of the current status of the global HIV pandemic and strategies to bring it under control. It updates numerous preventive approaches including behavioral interventions, male circumcision, pre- and post-exposure prophylaxis, vaccines, and microbicides. The manuscript summarizes current anti-retroviral treatment options, their impact in the western world, and difficulties faced by emerging and resource-limited nations in providing and maintaining appropriate treatment regimens. Current clinical and pre-clinical approaches towards a cure for HIV are described, including new drug compounds that target viral reservoirs and gene therapy approaches aimed at altering susceptibility to HIV infection. Recent progress in vaccine development is summarized, including novel approaches and new discoveries.

Status and progress of the RERTR program in the year 2004

International Nuclear Information System (INIS)

Travelli, A.

2005-01-01

The overall status of the RERTR program at the time of the last RERTR meeting is reviewed and the progress achieved since that meeting is described. In the fuel area, unexpected failures of LEU U-Mo dispersion plates and tubes under irradiation testing have prompted a revision of the plans to qualify these fuels. While potential solutions to the difficulties with U-Mo dispersion fuels are being explored in collaboration with our international partners, greater emphasis has been placed on accelerating development of monolithic LEU U-Mo fuel. The feasibility of converting several Russian-designed research reactors to LEU fuels has been addressed, and progress has been made in the development of LEU based 99 Mo production processes. The Russian RERTR program has made significant advances. A very important event of 2004 was the US DOE establishment of the Global Threat Reduction Initiative (GTRI). This new program accelerates and combines under the same US DOE management several programs, including RERTR, which aim to secure, remove, or dispose of, nuclear and other radioactive materials throughout the world that are vulnerable to theft by terrorists. (author)

Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities

Directory of Open Access Journals (Sweden)

Duy T. Dao

2017-10-01

Full Text Available Micronutrients refer to a group of organic vitamins and inorganic trace elements that serve many functions in metabolism. Assessment of micronutrient status in critically ill children is challenging due to many complicating factors, such as evolving metabolic demands, immature organ function, and varying methods of feeding that affect nutritional dietary intake. Determination of micronutrient status, especially in children, usually relies on a combination of biomarkers, with only a few having been established as a gold standard. Almost all micronutrients display a decrease in their serum levels in critically ill children, resulting in an increased risk of deficiency in this setting. While vitamin D deficiency is a well-known phenomenon in critical illness and can predict a higher need for intensive care, serum concentrations of many trace elements such as iron, zinc, and selenium decrease as a result of tissue redistribution in response to systemic inflammation. Despite a decrease in their levels, supplementation of micronutrients during times of severe illness has not demonstrated clear benefits in either survival advantage or reduction of adverse outcomes. For many micronutrients, the lack of large and randomized studies remains a major hindrance to critically evaluating their status and clinical significance.

E-Learning in Supplemental Educational Systems in Taiwan: Present Status and Future Challenges

Science.gov (United States)

Zhang, Ke; Hung, Jui-Long

2009-01-01

As Taiwan's full-scale e-learning initiatives moved to the seventh year in 2009, the current status and challenges of e-learning development there are yet to be fully understood. Further extending Zhang and Hung's (2006) investigation on e-learning in all universities and colleges in Taiwan, this study investigated the after-school programs (ASPs)…

Health Journalism: Health Reporting Status and Challenges.

Science.gov (United States)

Keshvari, Mahrokh; Yamani, Niko; Adibi, Peyman; Shahnazi, Hossein

2018-01-01

Media play crucial role in disseminating health information. Due to the importance of accurate health news reports, and the national need to professionalism in health journalism, this study aimed to investigate the characteristics of health journalists, and health reporting status and the challenges involved. Using consensus sampling, this descriptive cross-sectional study was conducted on all health news reporters in Isfahan (34 journalists) in 2015-2016. Data collection was done via a researcher-made questionnaire. Content validity of the questionnaire was determined by qualitative method and based on the opinions of six experts. The test-retest reliability coefficient was 98.0. Data analysis was done by Statistical Package for the Social Sciences, version 16 and descriptive statistics and content analysis were used for analyzing the responses to two open questions. Among 34 journalists, 56% were women and 44% men; the majority of journalists (65%) had no specialized training on health reporting, 35% of journalists were not able to understand the health issues, and the knowledge of medical terminology in 59% of them was moderate to low. The most important required skill for reporters was the ability to interpret medical research reports (88%), 97% were eager to participate in specialized health education. Our study showed that health journalists lacked knowledge and specialized training for dissemination of health news. This has brought about serious challenges. Thus, development and implementation of training courses in close collaboration with educational department of the Ministry of Health and news programs professionals at Islamic Republic of Iran Broadcasting is highly recommended.

Psychotherapy for Borderline Personality Disorder: Progress and Remaining Challenges.

Science.gov (United States)

Links, Paul S; Shah, Ravi; Eynan, Rahel

2017-03-01

The main purpose of this review was to critically evaluate the literature on psychotherapies for borderline personality disorder (BPD) published over the past 5 years to identify the progress with remaining challenges and to determine priority areas for future research. A systematic review of the literature over the last 5 years was undertaken. The review yielded 184 relevant abstracts, and after applying inclusion criteria, 16 articles were fully reviewed based on the articles' implications for future research and/or clinical practice. Our review indicated that patients with various severities benefited from psychotherapy; more intensive therapies were not significantly superior to less intensive therapies; enhancing emotion regulation processes and fostering more coherent self-identity were important mechanisms of change; therapies had been extended to patients with BPD and posttraumatic stress disorder; and more research was needed to be directed at functional outcomes.

Gradient models in molecular biophysics: progress, challenges, opportunities

Science.gov (United States)

Bardhan, Jaydeep P.

2013-12-01

In the interest of developing a bridge between researchers modeling materials and those modeling biological molecules, we survey recent progress in developing nonlocal-dielectric continuum models for studying the behavior of proteins and nucleic acids. As in other areas of science, continuum models are essential tools when atomistic simulations (e.g., molecular dynamics) are too expensive. Because biological molecules are essentially all nanoscale systems, the standard continuum model, involving local dielectric response, has basically always been dubious at best. The advanced continuum theories discussed here aim to remedy these shortcomings by adding nonlocal dielectric response. We begin by describing the central role of electrostatic interactions in biology at the molecular scale, and motivate the development of computationally tractable continuum models using applications in science and engineering. For context, we highlight some of the most important challenges that remain, and survey the diverse theoretical formalisms for their treatment, highlighting the rigorous statistical mechanics that support the use and improvement of continuum models. We then address the development and implementation of nonlocal dielectric models, an approach pioneered by Dogonadze, Kornyshev, and their collaborators almost 40 years ago. The simplest of these models is just a scalar form of gradient elasticity, and here we use ideas from gradient-based modeling to extend the electrostatic model to include additional length scales. The review concludes with a discussion of open questions for model development, highlighting the many opportunities for the materials community to leverage its physical, mathematical, and computational expertise to help solve one of the most challenging questions in molecular biology and biophysics.

Technical progress faced with the challenges of the energy sector in the future

International Nuclear Information System (INIS)

Maillard, D.

1999-01-01

The colloquium organised by the Association of Energy Economists dealing with the theme 'Technical progress faced with the challenges of the energy sector in the future' takes place against a backdrop of ever-increasing initiatives in this field, for example at the World Energy Council or the International Energy Agency Faith in technical progress is widespread but should be supported by studies without any preconceived ideas. Research and development efforts must be fully supported, and in a climate of opening markets and liberalization the public authorities have a major role to pay. Historically, the markets have always been able to meet new needs thanks to technology, but the ambitious targets that the international community has set itself regarding the emission of greenhouse gases imply technical improvements and major investments. (authors)

Progress and challenges of carbon nanotube membrane in water treatment

KAUST Repository

Lee, Jieun

2016-05-25

The potential of the carbon nanotube (CNT) membrane has been highly strengthened in water treatment during the last decade. According to works published up to now, the unique and excellent characteristics of CNT outperformed conventional polymer membranes. Such achievements of CNT membranes are greatly dependent on their fabrication methods. Further, the intrinsic properties of CNT could be a critical factor of applicability to membrane processes. This article provides an explicit and systematic review of the progress of CNT membranes addressing the current epidemic—whether (i) the CNT membranes could tackle current challenges in the pressure- or thermally driven membrane processes and (ii) CNT hybrid nanocomposite as a new generation of materials could complement current CNT-enhanced membrane. © 2016 Taylor & Francis Group, LLC.

Gradient Models in Molecular Biophysics: Progress, Challenges, Opportunities.

Science.gov (United States)

Bardhan, Jaydeep P

2013-12-01

In the interest of developing a bridge between researchers modeling materials and those modeling biological molecules, we survey recent progress in developing nonlocal-dielectric continuum models for studying the behavior of proteins and nucleic acids. As in other areas of science, continuum models are essential tools when atomistic simulations (e.g. molecular dynamics) are too expensive. Because biological molecules are essentially all nanoscale systems, the standard continuum model, involving local dielectric response, has basically always been dubious at best. The advanced continuum theories discussed here aim to remedy these shortcomings by adding features such as nonlocal dielectric response, and nonlinearities resulting from dielectric saturation. We begin by describing the central role of electrostatic interactions in biology at the molecular scale, and motivate the development of computationally tractable continuum models using applications in science and engineering. For context, we highlight some of the most important challenges that remain and survey the diverse theoretical formalisms for their treatment, highlighting the rigorous statistical mechanics that support the use and improvement of continuum models. We then address the development and implementation of nonlocal dielectric models, an approach pioneered by Dogonadze, Kornyshev, and their collaborators almost forty years ago. The simplest of these models is just a scalar form of gradient elasticity, and here we use ideas from gradient-based modeling to extend the electrostatic model to include additional length scales. The paper concludes with a discussion of open questions for model development, highlighting the many opportunities for the materials community to leverage its physical, mathematical, and computational expertise to help solve one of the most challenging questions in molecular biology and biophysics.

Gradient Models in Molecular Biophysics: Progress, Challenges, Opportunities

Science.gov (United States)

Bardhan, Jaydeep P.

2014-01-01

In the interest of developing a bridge between researchers modeling materials and those modeling biological molecules, we survey recent progress in developing nonlocal-dielectric continuum models for studying the behavior of proteins and nucleic acids. As in other areas of science, continuum models are essential tools when atomistic simulations (e.g. molecular dynamics) are too expensive. Because biological molecules are essentially all nanoscale systems, the standard continuum model, involving local dielectric response, has basically always been dubious at best. The advanced continuum theories discussed here aim to remedy these shortcomings by adding features such as nonlocal dielectric response, and nonlinearities resulting from dielectric saturation. We begin by describing the central role of electrostatic interactions in biology at the molecular scale, and motivate the development of computationally tractable continuum models using applications in science and engineering. For context, we highlight some of the most important challenges that remain and survey the diverse theoretical formalisms for their treatment, highlighting the rigorous statistical mechanics that support the use and improvement of continuum models. We then address the development and implementation of nonlocal dielectric models, an approach pioneered by Dogonadze, Kornyshev, and their collaborators almost forty years ago. The simplest of these models is just a scalar form of gradient elasticity, and here we use ideas from gradient-based modeling to extend the electrostatic model to include additional length scales. The paper concludes with a discussion of open questions for model development, highlighting the many opportunities for the materials community to leverage its physical, mathematical, and computational expertise to help solve one of the most challenging questions in molecular biology and biophysics. PMID:25505358

Competency-based education in anesthesiology: history and challenges.

Science.gov (United States)

Ebert, Thomas J; Fox, Chris A

2014-01-01

The Accreditation Council for Graduate Medical Education is transitioning to a competency-based system with milestones to measure progress and define success of residents. The confines of the time-based residency will be relaxed. Curriculum must be redesigned and assessments will need to be precise and in-depth. Core anesthesiology faculty will be identified and will be the "trained observers" of the residents' progress. There will be logistic challenges requiring creative management by program directors. There may be residents who achieve "expert" status earlier than the required 36 months of clinical anesthesia education, whereas others may struggle to achieve acceptable status and will require additional education time. Faculty must accept both extremes without judgment. Innovative new educational opportunities will need to be created for fast learners. Finally, it will be important that residents embrace this change. This will require programs to clearly define the specific aims and measurement endpoints for advancement and success.

Improving the Status of Women in the Third World: A Challenge to Adult Educators.

Science.gov (United States)

Clark, Elmer J.

Adult educators face a challenge if they are to aid in the improvement of the status of women in the Third World. Women in developing countries, especially those in rural and poverty areas, are often restricted to second class educational and work opportunities. Adult educators could contribute to the reduction of such discrimination in the…

Good, now keep going: challenging the status quo in STEM pipeline and access programs

Science.gov (United States)

Wiseman, Dawn; Herrmann, Randy

2018-03-01

This contribution engages in conversation with McMahon, Griese, and Kenyon (this issue) to consider how the SURE program they describe represents a pragmatic approach to addressing the issue of underrepresentation of Indigenous people in STEM post-secondary programs. We explore how such programs are generally positioned and how they might be positioned differently to challenge the status quo within Western post-secondary institutions. The challenge arises from moving beyond the immediate pragmatics of addressing an identifiable issue framed as a problem to considering how post-secondary institutions and people developing access recruitment programs might begin unlearning colonialism.

The Office of Site Closure: Progress in the Face of Challenges

International Nuclear Information System (INIS)

Fiore, J. J.; Murphie, W. E.; Meador, S. W.

2002-01-01

The Office of Site Closure (OSC) was formed in November 1999 when the Department of Energy's (DOE's) Office of Environmental Management (EM) reorganized to focus specifically on site cleanup and closure. OSC's objective is to achieve safe and cost-effective cleanups and closures that are protective of our workers, the public, and the environment, now and in the future. Since its inception, OSC has focused on implementing a culture of safe closure, with emphasis in three primary areas: complete our responsibility for the Closure Sites Rocky Flats, Mound, Fernald, Ashtabula, and Weldon Spring; complete our responsibility for cleanup at sites where the DOE mission has been completed (examples include Battelle King Avenue and Battelle West Jefferson in Columbus, and General Atomics) or where other Departmental organizations have an ongoing mission (examples include the Brookhaven, Livermore, or Los Alamos National Laboratories, and the Nevada Test Site); and create a framework a nd develop specific business closure tools that will help sites close, such as guidance for and decisions on post-contract benefit liabilities, records retention, and Federal employee incentives for site closure. This paper discusses OSC's 2001 progress in achieving site cleanups, moving towards site closure, and developing specific business closure tools to support site closure. It describes the tools used to achieve progress towards cleanup and closure, such as the application of new technologies, changes in contracting approaches, and the development of agreements between sites and with host states. The paper also identifies upcoming challenges and explores options for how Headquarters and the sites can work together to address these challenges. Finally, it articulates OSC's new focus on oversight of Field Offices to ensure they have the systems in place to oversee contractor activities resulting in site cleanups and closures

The Glen Canyon Dam adaptive management program: progress and immediate challenges

Science.gov (United States)

Hamill, John F.; Melis, Theodore S.; Boon, Philip J.; Raven, Paul J.

2012-01-01

Adaptive management emerged as an important resource management strategy for major river systems in the United States (US) in the early 1990s. The Glen Canyon Dam Adaptive Management Program (‘the Program’) was formally established in 1997 to fulfill a statutory requirement in the 1992 Grand Canyon Protection Act (GCPA). The GCPA aimed to improve natural resource conditions in the Colorado River corridor in the Glen Canyon National Recreation Area and Grand Canyon National Park, Arizona that were affected by the Glen Canyon dam. The Program achieves this by using science and a variety of stakeholder perspectives to inform decisions about dam operations. Since the Program started the ecosystem is now much better understood and several biological and physical improvements have been achieved. These improvements include: (i) an estimated 50% increase in the adult population of endangered humpback chub (Gila cypha) between 2001 and 2008, following previous decline; (ii) a 90% decrease in non-native rainbow trout (Oncorhynchus mykiss), which are known to compete with and prey on native fish, as a result of removal experiments; and (iii) the widespread reappearance of sandbars in response to an experimental high-flow release of dam water in March 2008.Although substantial progress has been made, the Program faces several immediate challenges. These include: (i) defining specific, measurable objectives and desired future conditions for important natural, cultural and recreational attributes to inform science and management decisions; (ii) implementing structural and operational changes to improve collaboration among stakeholders; (iii) establishing a long-term experimental programme and management plan; and (iv) securing long-term funding for monitoring programmes to assess ecosystem and other responses to management actions. Addressing these challenges and building on recent progress will require strong and consistent leadership from the US Department of the Interior

Progress and challenges to the global waste management system.

Science.gov (United States)

Singh, Jagdeep; Laurenti, Rafael; Sinha, Rajib; Frostell, Björn

2014-09-01

Rapid economic growth, urbanization and increasing population have caused (materially intensive) resource consumption to increase, and consequently the release of large amounts of waste to the environment. From a global perspective, current waste and resource management lacks a holistic approach covering the whole chain of product design, raw material extraction, production, consumption, recycling and waste management. In this article, progress and different sustainability challenges facing the global waste management system are presented and discussed. The study leads to the conclusion that the current, rather isolated efforts, in different systems for waste management, waste reduction and resource management are indeed not sufficient in a long term sustainability perspective. In the future, to manage resources and wastes sustainably, waste management requires a more systems-oriented approach that addresses the root causes for the problems. A specific issue to address is the development of improved feedback information (statistics) on how waste generation is linked to consumption. © The Author(s) 2014.

Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems

Directory of Open Access Journals (Sweden)

Feng Jiang

2015-10-01

Full Text Available Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX, are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

PROGRESS and CHALLENGES IN CLEANUP OF HANFORDS TANK WASTES

International Nuclear Information System (INIS)

HEWITT, W.M.; SCHEPENS, R.

2006-01-01

The River Protection Project (RPP), which is managed by the Department of Energy (DOE) Office of River Protection (ORP), is highly complex from technical, regulatory, legal, political, and logistical perspectives and is the largest ongoing environmental cleanup project in the world. Over the past three years, ORP has made significant advances in its planning and execution of the cleanup of the Hartford tank wastes. The 149 single-shell tanks (SSTs), 28 double-shell tanks (DSTs), and 60 miscellaneous underground storage tanks (MUSTs) at Hanford contain approximately 200,000 m 3 (53 million gallons) of mixed radioactive wastes, some of which dates back to the first days of the Manhattan Project. The plan for treating and disposing of the waste stored in large underground tanks is to: (1) retrieve the waste, (2) treat the waste to separate it into high-level (sludge) and low-activity (supernatant) fractions, (3) remove key radionuclides (e.g., Cs-137, Sr-90, actinides) from the low-activity fraction to the maximum extent technically and economically practical, (4) immobilize both the high-level and low-activity waste fractions by vitrification, (5) interim store the high-level waste fraction for ultimate disposal off-site at the federal HLW repository, (6) dispose the low-activity fraction on-site in the Integrated Disposal Facility (IDF), and (7) close the waste management areas consisting of tanks, ancillary equipment, soils, and facilities. Design and construction of the Waste Treatment and Immobilization Plant (WTP), the cornerstone of the RPP, has progressed substantially despite challenges arising from new seismic information for the WTP site. We have looked closely at the waste and aligned our treatment and disposal approaches with the waste characteristics. For example, approximately 11,000 m 3 (2-3 million gallons) of metal sludges in twenty tanks were not created during spent nuclear fuel reprocessing and have low fission product concentrations. We plan to

"Are You an African?" The Politics of Self-Construction in Status-Based Social Movements.

Science.gov (United States)

McCorkel, Jill; Rodriquez, Jason

2009-05-01

Current debates over identity politics hinge on the question of whether status-based social movements encourage parochialism and self-interest or create possibilities for mutual recognition across lines of difference. Our article explores this question through comparative, ethnographic study of two racially progressive social movements, "pro-black" abolitionism and "conscious" hip hop. We argue that status-based social movements not only enable collective identity, but also the personal identities or selves of their participants. Beliefs about the self create openings and obstacles to mutual recognition and progressive social action. Our analysis centers on the challenges that an influx of progressive, anti-racist whites posed to each movement. We examine first how each movement configured movement participation and racial identity and then how whites crafted strategic narratives of the self to account for their participation in a status-based movement they were not directly implicated in. We conclude with an analysis of the implications of these narratives for a critical politics of recognition. Keywords: identity politics, social movements, race, self, hip hop.

IAEA Mission Sees Significant Progress in Georgia’s Regulatory Framework, Challenges Ahead

International Nuclear Information System (INIS)

2018-01-01

An International Atomic Energy Agency (IAEA) team of experts said Georgia has made significant progress in strengthening its regulatory framework for nuclear and radiation safety. The team also pointed to challenges ahead as Georgia seeks to achieve further progress. The Integrated Regulatory Review Service (IRRS) team concluded a 10-day mission on 28 February to assess the regulatory safety framework in Georgia. The mission was conducted at the request of the Government and hosted by the Agency of Nuclear and Radiation Safety (ANRS), which is responsible for regulatory oversight in the country. IRRS missions are designed to strengthen the effectiveness of the national safety regulatory infrastructure, while recognizing the responsibility of each State to ensure nuclear and radiation safety. Georgia uses radioactive sources in medicine and industry and operates radioactive waste management facilities. It has decommissioned its only research reactor and has no nuclear power plants. In recent years, the Government and ANRS, with assistance from the IAEA, introduced new safety regulations and increased the number of regulatory inspections.

Progress in Application of the Neurosciences to an Understanding of Human Learning: The Challenge of Finding a Middle-Ground Neuroeducational Theory

Science.gov (United States)

Anderson, O. Roger

2014-01-01

Modern neuroscientific research has substantially enhanced our understanding of the human brain. However, many challenges remain in developing a strong, brain-based theory of human learning, especially in complex environments such as educational settings. Some of the current issues and challenges in our progress toward developing comprehensive…

Challenges to code status discussions for pediatric patients.

Directory of Open Access Journals (Sweden)

Katherine E Kruse

Full Text Available In the context of serious or life-limiting illness, pediatric patients and their families are faced with difficult decisions surrounding appropriate resuscitation efforts in the event of a cardiopulmonary arrest. Code status orders are one way to inform end-of-life medical decision making. The objectives of this study are to evaluate the extent to which pediatric providers have knowledge of code status options and explore the association of provider role with (1 knowledge of code status options, (2 perception of timing of code status discussions, (3 perception of family receptivity to code status discussions, and (4 comfort carrying out code status discussions.Nurses, trainees (residents and fellows, and attending physicians from pediatric units where code status discussions typically occur completed a short survey questionnaire regarding their knowledge of code status options and perceptions surrounding code status discussions.Single center, quaternary care children's hospital.203 nurses, 31 trainees, and 29 attending physicians in 4 high-acuity pediatric units responded to the survey (N = 263, 90% response rate. Based on an objective knowledge measure, providers demonstrate poor understanding of available code status options, with only 22% of providers able to enumerate more than two of four available code status options. In contrast, provider groups self-report high levels of familiarity with available code status options, with attending physicians reporting significantly higher levels than nurses and trainees (p = 0.0125. Nurses and attending physicians show significantly different perception of code status discussion timing, with majority of nurses (63.4% perceiving discussions as occurring "too late" or "much too late" and majority of attending physicians (55.6% perceiving the timing as "about right" (p<0.0001. Attending physicians report significantly higher comfort having code status discussions with families than do nurses or trainees

The progress and challenges of implementation of the Framework Convention on Tobacco Control (WHO FCTC) in Kyrgyz Republic

OpenAIRE

Chinara Bekbasarova

2018-01-01

Background and challenges to implementation The Kyrgyz Republic is Party of the WHO FCTC since August 23, 2006. This abstract analyzes progress and challenges during 10 years of implementation of WHO´s FCTC Intervention or response National Tobacco Control (TC) Law was adopted on August 21, 2006, entered into force on December 19, 2006 and was amended and supplemented during 10 years 2 times. TC measures were included, as one of main priorities, in the National Program on Heal...

Microbial production of nattokinase: current progress, challenge and prospect.

Science.gov (United States)

Cai, Dongbo; Zhu, Chengjun; Chen, Shouwen

2017-05-01

Nattokinase (EC 3.4.21.62) is a profibrinolytic serine protease with a potent fibrin-degrading activity, and it has been produced by many host strains. Compared to other fibrinolytic enzymes (urokinase, t-PA and streprokinase), nattokinase shows the advantages of having no side effects, low cost and long life-time, and it has the potential to be used as a drug for treating cardiovascular disease and served as a functional food additive. In this review, we focused on screening of producing strains, genetic engineering, fermentation process optimization for microbial nattokinase production, and the extraction and purification of nattokinase were also discussed in this particular chapter. The selection of optimal nattokinase producing strain was the crucial starting element for improvement of nattokinase production. Genetic engineering, protein engineering, fermentation optimization and process control have been proved to be the effective strategies for enhancement of nattokinase production. Also, extraction and purification of nattokinase are critical for the quality evaluation of nattokinase. Finally, the prospect of microbial nattokinase production was also discussed regarding the recent progress, challenge, and trends in this field.

Programmatic challenges in obtaining and confirming the pneumococcal vaccination status of cochlear implant recipients.

Science.gov (United States)

Carpenter, Ryan M; Limb, Charles J; Francis, Howard W; Gottschalk, Barbara; Niparko, John K

2010-10-01

Bacterial meningitis represents a substantial concern for individuals with cochlear implants (CIs). Chart review and direct patient and family correspondence to ascertain vaccination status. Information dissemination via brochure and electronic media, ongoing reminders of the importance of vaccination when confirmation of vaccination was not received. Marked improvement in vaccination rates ranging from 49% to 99% across different patient populations. Importantly, many patients received their vaccinations only after follow-up reminders. Ensuring optimal vaccination of all CI recipients against high-risk pathogens is a significantly challenging task. Maximizing vaccination rates in CI users will require an ongoing, active effort of information dissemination, documentation of compliance, and well-designed behavioral systems to streamline the pragmatic challenges in vaccination delivery.

“Are You an African?” The Politics of Self-Construction in Status-Based Social Movements

Science.gov (United States)

McCorkel, Jill; Rodriquez, Jason

2011-01-01

Current debates over identity politics hinge on the question of whether status-based social movements encourage parochialism and self-interest or create possibilities for mutual recognition across lines of difference. Our article explores this question through comparative, ethnographic study of two racially progressive social movements, “pro-black” abolitionism and “conscious” hip hop. We argue that status-based social movements not only enable collective identity, but also the personal identities or selves of their participants. Beliefs about the self create openings and obstacles to mutual recognition and progressive social action. Our analysis centers on the challenges that an influx of progressive, anti-racist whites posed to each movement. We examine first how each movement configured movement participation and racial identity and then how whites crafted strategic narratives of the self to account for their participation in a status-based movement they were not directly implicated in. We conclude with an analysis of the implications of these narratives for a critical politics of recognition. Keywords: identity politics, social movements, race, self, hip hop. PMID:21731113

Challenges and status of ITER conductor production

International Nuclear Information System (INIS)

Devred, A; Backbier, I; Bessette, D; Bevillard, G; Gardner, M; Jong, C; Lillaz, F; Mitchell, N; Romano, G; Vostner, A

2014-01-01

Taking the relay of the large Hadron collider (LHC) at CERN, ITER has become the largest project in applied superconductivity. In addition to its technical complexity, ITER is also a management challenge as it relies on an unprecedented collaboration of seven partners, representing more than half of the world population, who provide 90% of the components as in-kind contributions. The ITER magnet system is one of the most sophisticated superconducting magnet systems ever designed, with an enormous stored energy of 51 GJ. It involves six of the ITER partners. The coils are wound from cable-in-conduit conductors (CICCs) made up of superconducting and copper strands assembled into a multistage cable, inserted into a conduit of butt-welded austenitic steel tubes. The conductors for the toroidal field (TF) and central solenoid (CS) coils require about 600 t of Nb 3 Sn strands while the poloidal field (PF) and correction coil (CC) and busbar conductors need around 275 t of Nb–Ti strands. The required amount of Nb 3 Sn strands far exceeds pre-existing industrial capacity and has called for a significant worldwide production scale up. The TF conductors are the first ITER components to be mass produced and are more than 50% complete. During its life time, the CS coil will have to sustain several tens of thousands of electromagnetic (EM) cycles to high current and field conditions, way beyond anything a large Nb 3 Sn coil has ever experienced. Following a comprehensive R and D program, a technical solution has been found for the CS conductor, which ensures stable performance versus EM and thermal cycling. Productions of PF, CC and busbar conductors are also underway. After an introduction to the ITER project and magnet system, we describe the ITER conductor procurements and the quality assurance/quality control programs that have been implemented to ensure production uniformity across numerous suppliers. Then, we provide examples of technical challenges that have been

Challenges and status of ITER conductor production

Science.gov (United States)

Devred, A.; Backbier, I.; Bessette, D.; Bevillard, G.; Gardner, M.; Jong, C.; Lillaz, F.; Mitchell, N.; Romano, G.; Vostner, A.

2014-04-01

Taking the relay of the large Hadron collider (LHC) at CERN, ITER has become the largest project in applied superconductivity. In addition to its technical complexity, ITER is also a management challenge as it relies on an unprecedented collaboration of seven partners, representing more than half of the world population, who provide 90% of the components as in-kind contributions. The ITER magnet system is one of the most sophisticated superconducting magnet systems ever designed, with an enormous stored energy of 51 GJ. It involves six of the ITER partners. The coils are wound from cable-in-conduit conductors (CICCs) made up of superconducting and copper strands assembled into a multistage cable, inserted into a conduit of butt-welded austenitic steel tubes. The conductors for the toroidal field (TF) and central solenoid (CS) coils require about 600 t of Nb3Sn strands while the poloidal field (PF) and correction coil (CC) and busbar conductors need around 275 t of Nb-Ti strands. The required amount of Nb3Sn strands far exceeds pre-existing industrial capacity and has called for a significant worldwide production scale up. The TF conductors are the first ITER components to be mass produced and are more than 50% complete. During its life time, the CS coil will have to sustain several tens of thousands of electromagnetic (EM) cycles to high current and field conditions, way beyond anything a large Nb3Sn coil has ever experienced. Following a comprehensive R&D program, a technical solution has been found for the CS conductor, which ensures stable performance versus EM and thermal cycling. Productions of PF, CC and busbar conductors are also underway. After an introduction to the ITER project and magnet system, we describe the ITER conductor procurements and the quality assurance/quality control programs that have been implemented to ensure production uniformity across numerous suppliers. Then, we provide examples of technical challenges that have been encountered and

Recent progress and modern challenges in applied mathematics, modeling and computational science

CERN Document Server

Makarov, Roman; Belair, Jacques

2017-01-01

This volume is an excellent resource for professionals in various areas of applications of mathematics, modeling, and computational science. It focuses on recent progress and modern challenges in these areas. The volume provides a balance between fundamental theoretical and applied developments, emphasizing the interdisciplinary nature of modern trends and detailing state-of-the-art achievements in Applied Mathematics, Modeling, and Computational Science.  The chapters have been authored by international experts in their respective fields, making this book ideal for researchers in academia, practitioners, and graduate students. It can also serve as a reference in the diverse selected areas of applied mathematics, modelling, and computational sciences, and is ideal for interdisciplinary collaborations.

Military Readiness: Progress and Challenges in Implementing the Navy’s Optimized Fleet Response Plan

Science.gov (United States)

2016-05-02

command and control under the OFRP contributes to wide swings in port workload , which in turn can have a negative effect on the private - sector industrial...for 53 percent of all private - sector aircraft carrier maintenance contracts and 70 percent of cruiser and destroyer contracts from fiscal years...their impact on the Navy; (2) the Navy’s goals and progress in implementing the OFRP; and (3) challenges faced by public and private shipyards

Effects of Tributyrin on Intestinal Energy Status, Antioxidative Capacity and Immune Response to Lipopolysaccharide Challenge in Broilers

Directory of Open Access Journals (Sweden)

Jiaolong Li

2015-12-01

Full Text Available This study was carried out to investigate the effects of tributyrin (TB on the growth performance, pro-inflammatory cytokines, intestinal morphology, energy status, disaccharidase activity, and antioxidative capacity of broilers challenged with lipopolysaccharide (LPS. A total of 160 one-day-old Cobb broilers were allocated to 1 of 4 treatments, with 4 replicated pens per treatment and 10 birds per pen. The experiment consisted of a 2×2 factorial arrangements of treatments with TB supplementation (0 or 500 mg/kg and LPS challenge (0 or 500 μg/kg body weight [BW]. On days 22, 24, and 26 of the trial, broilers received an intraperitoneal administration of 500 μg/kg BW LPS or saline. Dietary TB showed no effect on growth performance. However, LPS challenge decreased the average daily gain of broilers from day 22 to day 26 of the trial. Dietary TB supplementation inhibited the increase of interleukin-1β (in the jejunum and ileum, interleukin-6 (in the duodenum and jejunum, and prostaglandin E2 (in the duodenum of LPS-challenged broilers. Similar inhibitory effects of TB in the activities of total nitric oxide synthase (in the ileum and inducible nitric oxide synthase (in the jejunum were also observed in birds challenged with LPS. Additionally, TB supplementation mitigated the decrease of ileal adenosine triphosphate, adenosine diphosphate and total adenine nucleotide and the reduction of jejunal catalase activity induced by LPS. Taken together, these results suggest that the TB supplementation was able to reduce the release of pro-inflammatory cytokines and improve the energy status and anti-oxidative capacity in the small intestine of LPS-challenged broilers.

Impacts of Mothers’ Occupation Status and Parenting Styles on Levels of Self-Control, Addiction to Computer Games, and Educational Progress of Adolescents

OpenAIRE

Abedini, Yasamin; Zamani, Bibi Eshrat; Kheradmand, Ali; Rajabizadeh, Ghodratollah

2012-01-01

Background Addiction to computer (video) games in adolescents and its relationship with educational progress has recently attracted the attention of rearing and education experts as well as organizations and institutes involved in physical and mental health. The current research attempted to propose a structural model of the relationships between parenting styles, mothers’ occupation status, and addiction to computer games, self-control, and educational progress of secondary school students. ...

Progress and challenges in the prevention and control of nonalcoholic fatty liver disease.

Science.gov (United States)

Cai, Jingjing; Zhang, Xiao-Jing; Li, Hongliang

2018-05-30

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide. Individuals with NAFLD have a high frequency of developing progressive liver disease and metabolism-related comorbidities, which result from of a lack of awareness and poor surveillance of the disease and a paucity of approved and effective therapies. Managing the complications of NAFLD has already begun to place a tremendous burden on health-care systems. Although efforts to identify effective therapies are underway, the lack of validated preclinical NAFLD models that represent the biology and outcomes of human disease remains a major barrier. This review summarizes the characteristics and prevalence of the disease and the status of our understanding of its mechanisms and potential therapeutic targets. © 2018 Wiley Periodicals, Inc.

Transformation of the education of health professionals in China: progress and challenges.

Science.gov (United States)

Hou, Jianlin; Michaud, Catherine; Li, Zhihui; Dong, Zhe; Sun, Baozhi; Zhang, Junhua; Cao, Depin; Wan, Xuehong; Zeng, Cheng; Wei, Bo; Tao, Lijian; Li, Xiaosong; Wang, Weimin; Lu, Yingqing; Xia, Xiulong; Guo, Guifang; Zhang, Zhiyong; Cao, Yunfei; Guan, Yuanzhi; Meng, Qingyue; Wang, Qing; Zhao, Yuhong; Liu, Huaping; Lin, Huiqing; Ke, Yang; Chen, Lincoln

2014-08-30

In this Review we examine the progress and challenges of China's ambitious 1998 reform of the world's largest health professional educational system. The reforms merged training institutions into universities and greatly expanded enrolment of health professionals. Positive achievements include an increase in the number of graduates to address human resources shortages, acceleration of production of diploma nurses to correct skill-mix imbalance, and priority for general practitioner training, especially of rural primary care workers. These developments have been accompanied by concerns: rapid expansion of the number of students without commensurate faculty strengthening, worries about dilution effect on quality, outdated curricular content, and ethical professionalism challenged by narrow technical training and growing admissions of students who did not express medicine as their first career choice. In this Review we underscore the importance of rebalance of the roles of health sciences institutions and government in educational policies and implementation. The imperative for reform is shown by a looming crisis of violence against health workers hypothesised as a result of many factors including deficient educational preparation and harmful profit-driven clinical practices. Copyright © 2014 Elsevier Ltd. All rights reserved.

Shark recreational fisheries: Status, challenges, and research needs.

Science.gov (United States)

Gallagher, Austin J; Hammerschlag, Neil; Danylchuk, Andy J; Cooke, Steven J

2017-05-01

For centuries, the primary manner in which humans have interacted with sharks has been fishing. A combination of their slow-growing nature and high use-values have resulted in population declines for many species around the world, and to date the vast majority of fisheries-related work on sharks has focused on the commercial sector. Shark recreational fishing remains an overlooked area of research despite the fact that these practices are popular globally and could present challenges to their populations. Here we provide a topical overview of shark recreational fisheries, highlighting their history and current status. While recreational fishing can provide conservation benefits under certain circumstances, we focus our discourse on the relatively understudied, potentially detrimental impacts these activities may have on shark physiology, behavior, and fitness. We took this angle given the realized but potentially underestimated significance of recreational fishing for shark conservation management plans and stock assessments, in hopes of creating a dialogue around sustainability. We also present a series of broad and focused research questions and underpin areas of future research need to assist with the development of this emergent area of research.

ITER and the fusion reactor: status and challenge to technology

International Nuclear Information System (INIS)

Lackner, K.

2001-01-01

Fusion has a high potential, but requires an integrated physics and technology effort without precedence in non-military R and D, the basic physics feasibility demonstration will be concluded with ITER, although R and D for efficiency improvement will continue. The essential technological issues remaining at the start of ITER operation concern materials questions: first wall components and radiation tolerant (low activation materials). This paper comprised just the copy of the slides presentation with the following subjects: magnetic confinement fusion, the Tokamak, progress in Tokamak performance, ITER: its geneology, physics basis-critical issues, cutaway of ITER-FEAT, R and D - divertor cassette (L-5), differences power plant-ITER, challenges for ITER and fusion plants, main technological problems (plasma facing materials), structural and functional materials for fusion power plants, ferritic steels, EUROFER development, improvements beyond ferritic steels, costing among others. (nevyjel)

Neonatal tetanus elimination in Pakistan: progress and challenges.

Science.gov (United States)

Lambo, Jonathan A; Nagulesapillai, Tharsiya

2012-12-01

Pakistan is one of the 34 countries that have not achieved the neonatal tetanus (NT) global elimination target set by the World Health Organization (WHO). NT, caused by Clostridium tetani, is a highly fatal infection of the neonatal period. It is one of the most underreported diseases and remains a major but preventable cause of neonatal and infant mortality in many developing countries. In 1989, the World Health Assembly called for the elimination of NT by 1995, and since then considerable progress has been made using the following strategies: clean delivery practices, routine tetanus toxoid (TT) immunization of pregnant women, and immunization of all women of childbearing age with three doses of TT vaccine in high-risk areas during supplementary immunization campaigns. This review presents the activities, progress, and challenges in achieving NT elimination in Pakistan. A review of the literature found TT vaccination coverage in Pakistan ranged from 60% to 74% over the last decade. Low vaccination coverage, the main driver for NT in Pakistan, is due to many factors, including demand failure for TT vaccine resulting from inadequate knowledge of TT vaccine among reproductive age females and inadequate information about the benefits of TT provided by health care workers and the media. Other factors linked to low vaccination coverage include residing in rural areas, lack of formal education, poor knowledge about place and time to get vaccinated, and lack of awareness about the importance of vaccination. A disparity exists in TT vaccination coverage and antenatal care between urban and rural areas due to access and utilization of health care services. NT reporting is incomplete, as cases from the private sector and rural areas are underreported. To successfully eliminate NT, women of reproductive age must be made aware of the benefits of TT vaccine, not only to themselves, but also to their families. Effective communication strategies for TT vaccine delivery and

Progress and challenges in utilization of palm oil biomass as fuel for decentralized electricity generation

Energy Technology Data Exchange (ETDEWEB)

Bazmi, Aqeel Ahmed [Process Systems Engineering Centre (PROSPECT), Department of Chemical Engineering, Faculty of Chemical and Natural Resources Engineering, University Technology Malaysia, Skudai 81310, Johor Bahru, JB (Malaysia); Biomass Conversion Research Center (BCRC), Department of Chemical Engineering, COMSATS Institute of Information Technology, Lahore (Pakistan); Zahedi, Gholamreza; Hashim, Haslenda [Process Systems Engineering Centre (PROSPECT), Department of Chemical Engineering, Faculty of Chemical and Natural Resources Engineering, University Technology Malaysia, Skudai 81310, Johor Bahru, JB (Malaysia)

2011-01-15

It has been broadly accepted worldwide that global warming, indeed, is the greatest threat of the time to the environment. Renewable energy (RE) is expected as a perfect solution to reduce global warming and to endorse sustainable development. Progressive release of greenhouse gases (GHG) from increasing energy-intensive industries has eventually caused human civilization to suffer. Realizing the exigency of reducing emissions and simultaneously catering to needs of industries, researchers foresee the RE as the perfect entrant to overcome these challenges. RE provides an effective option for the provision of energy services from the technical point of view while biomass, a major source of energy in the world until before industrialization when fossil fuels become dominant, appears an important renewable source of energy and researches have proven from time to time its viability for large-scale production. Being a widely spread source, biomass offers the execution of decentralized electricity generation gaining importance in liberalized electricity markets. The decentralized power is characterized by generation of electricity nearer to the demand centers, meeting the local energy needs. Researchers envisaged an increasing decentralization of power supply, expected to make a particular contribution to climate protection. This article investigates the progress and challenges for decentralized electricity generation by palm oil biomass according to the overall concept of sustainable development. (author)

Progress and challenges in utilization of palm oil biomass as fuel for decentralized electricity generation

International Nuclear Information System (INIS)

Bazmi, Aqeel Ahmed; Zahedi, Gholamreza; Hashim, Haslenda

2011-01-01

It has been broadly accepted worldwide that global warming, indeed, is the greatest threat of the time to the environment. Renewable energy (RE) is expected as a perfect solution to reduce global warming and to endorse sustainable development. Progressive release of greenhouse gases (GHG) from increasing energy-intensive industries has eventually caused human civilization to suffer. Realizing the exigency of reducing emissions and simultaneously catering to needs of industries, researchers foresee the RE as the perfect entrant to overcome these challenges. RE provides an effective option for the provision of energy services from the technical point of view while biomass, a major source of energy in the world until before industrialization when fossil fuels become dominant, appears an important renewable source of energy and researches have proven from time to time its viability for large-scale production. Being a widely spread source, biomass offers the execution of decentralized electricity generation gaining importance in liberalized electricity markets. The decentralized power is characterized by generation of electricity nearer to the demand centers, meeting the local energy needs. Researchers envisaged an increasing decentralization of power supply, expected to make a particular contribution to climate protection. This article investigates the progress and challenges for decentralized electricity generation by palm oil biomass according to the overall concept of sustainable development. (author)

COMPARISON OF EFFECTIVENESS OF A PROGRESSIVE MOBILIZATION AND MOZART MUSIC THERAPY ON NON-INVASIVE HEMODYNAMIC STATUS CHANGES IN PATIENTS WITH HEAD INJURY IN THE INTENSIVE CARE UNIT

Directory of Open Access Journals (Sweden)

Novi Indriani

2018-05-01

Full Text Available Background: The instability of hemodynamic status in patients with head injury with decreased consciousness has an effect on the increase of intracranial pressure. The recovery of hemodynamic status can be done through nursing intervention either by providing a sensory stimulus (music therapy or motor stimulus (progressive mobilization. Objective: To compare the effectiveness of progressive mobilization of level I with Mozart's music therapy on non-invasive hemodynamic status changes in patients with head injury with decreased awareness. Methods: This was a quasy-experimental study with pretest-posttest design. There were 34 samples selected using consecutive sampling, which 17 samples assigned in a group of progressive mobilization and group of music therapy. Paired t-test and Wilcoxon test were used for paired group, and Independent t-test and Mann-Whitney test for unpaired group. Results: Progressive mobilization of level I had significant effect on changes in systolic blood pressure (p = 0.0001, diastolic blood pressure (p = 0.002 and MAP (p = 0.019, and no significant effect on heart rate (p = 0.155, respiration (p = 0.895 and oxygen saturation (p = 0.248. Mozart's music therapy had a significant effect on changes in systolic blood pressure (p = 0.0001, diastolic blood pressure (p = 0.0001, respiration (p= 0.032 and oxygen saturation (p = 0.008, but no effect on MAP (p = 0.561. There was a significant difference between the two interventions in the systolic blood pressure and heart rate variables (p 0.05. Conclusion: The Mozart's music therapy is more effective on non-invasive hemodynamic status changes in patients with head injury with decreased consciousness compared with progressive mobilization of level I.

ILRS: Current Status and Future Challenges

Science.gov (United States)

Pearlman, M. R.; Bianco, G.; Merkowitz, S.; Noll, C. E.; Pavlis, E. C.; Shargorodsky, V.; Zhongping, Z.

2016-12-01

The International Laser Ranging Service (ILRS) is expanding its ground tracking capability with new stations and upgrades to current stations. Our Russian colleagues have installed new stations in Brasilia and South Africa, and have several other sites in process or in planning. The NASA Space Geodesy Program is preparing equipment for U.S. sites (McDonald and Haleakala) and with the Norwegian National Mapping Agency in Ny Ålesund; further deployments are planned. Upgrades continue at sites in China, and new sites are underway or planned in Europe and India. Stations are moving to higher repetition rates and more efficient detection to enhance satellite interleaving capability; some stations have already implemented automated processes that could lead to around-the-clock operation to increase temporal coverage and to make more efficient use of personnel. The ILRS roster of supported satellites continues to grow with the addition of the LARES satellite to augment tracking for the improvement of the ITRF. New GNSS constellations and geosynchronous satellites now bring the total roster to over 80 satellites - so much so, that new tracking strategies and time and location multiplexing are under consideration. There continues to be strong interest in Lunar Ranging. New applications of one-way and two-way laser ranging include ps-accurate time transfer, laser transponders for interplanetary ranging, and tracking of space debris. New laser ranging data products are being developed, including satellite orbit products, satellite orientation, gravity field products, and products to characterize the quality of data and station performance. This talk will give a brief summary of recent progress, current challenges and a view of the path ahead.

Bicarbonate therapy for prevention of chronic kidney disease progression.

Science.gov (United States)

Łoniewski, Igor; Wesson, Donald E

2014-03-01

Kidney injury in chronic kidney disease (CKD) is likely multifactorial, but recent data support that a component is mediated by mechanisms used by the kidney to increase acidification in response to an acid challenge to systemic acid-base status. If so, systemic alkalization might attenuate this acid-induced component of kidney injury. An acid challenge to systemic acid-base status increases nephron acidification through increased production of endothelin, aldosterone, and angiotensin II, each of which can contribute to kidney inflammation and fibrosis that characterizes CKD. Systemic alkalization that ameliorates an acid challenge might attenuate the contributions of angiotensin II, endothelin, and aldosterone to kidney injury. Some small clinical studies support the efficacy of alkalization in attenuating kidney injury and slowing glomerular filtration rate decline in CKD. This review focuses on the potential that orally administered NaHCO₃ prevents CKD progression and additionally addresses its mechanism of action, side effects, possible complications, dosage, interaction, galenic form description, and contraindications. Current National Kidney Foundation guidelines recommend oral alkali, including NaHCO₃(-), in CKD patients with serum HCO₃(-) <22 mmol/l. Although oral alkali can be provided by other medications and by base-inducing dietary constituents, oral NaHCO₃ will be the focus of this review because of its relative safety and apparent efficacy, and its comparatively low cost.

Challenges of maintaining polio-free status of the European Region.

Science.gov (United States)

Khetsuriani, Nino; Pfeifer, Dina; Deshevoi, Sergei; Gavrilin, Eugene; Shefer, Abigail; Butler, Robb; Jankovic, Dragan; Spataru, Roman; Emiroglu, Nedret; Martin, Rebecca

2014-11-01

The European region, certified as polio free in 2002, had recent wild poliovirus (WPV) introductions, resulting in a major outbreak in Central Asian countries and Russia in 2010 and in current widespread WPV type 1 circulation in Israel, which endangered the polio-free status of the region. We assessed the data on the major determinants of poliovirus transmission risk (population immunity, surveillance, and outbreak preparedness) and reviewed current threats and measures implemented in response to recent WPV introductions. Despite high regional vaccination coverage and functioning surveillance, several countries in the region are at high or intermediate risk of poliovirus transmission. Coverage remains suboptimal in some countries, subnational geographic areas, and population groups, and surveillance (acute flaccid paralysis, enterovirus, and environmental) needs further strengthening. Supplementary immunization activities, which were instrumental in the rapid interruption of WPV1 circulation in 2010, should be implemented in high-risk countries to close population immunity gaps. National polio outbreak preparedness plans need strengthening. Immunization efforts to interrupt WPV transmission in Israel should continue. The European region has successfully maintained its polio-free status since 2002, but numerous challenges remain. Staying polio free will require continued coordinated efforts, political commitment and financial support from all countries. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Building a Grad Nation: Progress and Challenge in Ending the High School Dropout Epidemic. Annual Update, 2010-2011

Science.gov (United States)

Balfanz, Robert; Bridgeland, John M.; Fox, Joanna Hornig; Moore, Laura A.

2011-01-01

America continues to make progress in meeting its high school dropout challenge. Leaders in education, government, nonprofits and business have awakened to the individual, social and economic costs of the dropout crisis and are working together to solve it. This year, all states, districts, and schools are required by law to calculate high school…

Front-end electronics and trigger systems-Status and challenges

International Nuclear Information System (INIS)

Spieler, Helmuth

2007-01-01

The past quarter century has brought about a revolution in front-end electronics for large-scale detector systems. Custom integrated circuits specifically tailored to the requirements of large detector systems have provided unprecedented performance and enabled systems that once were deemed impossible. The evolution of integrated circuit readouts in strip detectors is summarized, the present status described, and challenges posed by the sLHC and ILC are discussed. Performance requirements increase, but key considerations remain as in the past: power dissipation, material, and services. Smaller CMOS feature sizes will not reduce the power required for the desired noise levels, but will improve digital power efficiency. Significant improvements appear to be practical in more efficient power distribution. Enhanced digital electronics have provided powerful trigger processors that greatly improve the trigger efficiency. In data readout systems, they also improve data throughput, while reducing power requirements. Concurrently with new developments in high energy physics, detector systems for cosmology and astrophysics have made great strides. As an example, a large-scale readout for superconducting bolometer arrays is described

Front-end electronics and trigger systems - status and challenges

International Nuclear Information System (INIS)

Spieler, Helmuth G; Spieler, Helmuth G

2007-01-01

The past quarter century has brought about a revolution in front-end electronics for large-scale detector systems. Custom integrated circuits specifically tailored to the requirements of large detector systems have provided unprecedented performance and enabled systems that once were deemed impossible. The evolution of integrated circuit readouts in strip detectors is summarized, the present status described, and challenges posed by the sLHC and ILC are discussed. Performance requirements increase, but key considerations remain as in the past: power dissipation, material, and services. Smaller CMOS feature sizes will not provide the required electronic noise at lower power, but will improve digital power efficiency. Significant improvements appear to be practical in more efficient power distribution. Enhanced digital electronics have provided powerful trigger processors that greatly improve the trigger efficiency. In data readout systems they also improve data throughput, while reducing power requirements. Concurrently with new developments in high energy physics, detector systems for cosmology and astrophysics have made great strides. As an example, a large-scale readout for superconducting bolometer arrays is described

Tunnel Junction with Perpendicular Magnetic Anisotropy: Status and Challenges

Directory of Open Access Journals (Sweden)

Mengxing Wang

2015-08-01

Full Text Available Magnetic tunnel junction (MTJ, which arises from emerging spintronics, has the potential to become the basic component of novel memory, logic circuits, and other applications. Particularly since the first demonstration of current induced magnetization switching in MTJ, spin transfer torque magnetic random access memory (STT-MRAM has sparked a huge interest thanks to its non-volatility, fast access speed, and infinite endurance. However, along with the advanced nodes scaling, MTJ with in-plane magnetic anisotropy suffers from modest thermal stability, high power consumption, and manufactural challenges. To address these concerns, focus of research has converted to the preferable perpendicular magnetic anisotropy (PMA based MTJ, whereas a number of conditions still have to be met before its practical application. This paper overviews the principles of PMA and STT, where relevant issues are preliminarily discussed. Centering on the interfacial PMA in CoFeB/MgO system, we present the fundamentals and latest progress in the engineering, material, and structural points of view. The last part illustrates potential investigations and applications with regard to MTJ with interfacial PMA.

Delaware: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Oklahoma: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Arkansas: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Mississippi: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Texas: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Georgia: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Maryland: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Louisiana: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Tennessee: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Kentucky: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

Orion Absolute Navigation System Progress and Challenge

Science.gov (United States)

Holt, Greg N.; D'Souza, Christopher

2012-01-01

The absolute navigation design of NASA's Orion vehicle is described. It has undergone several iterations and modifications since its inception, and continues as a work-in-progress. This paper seeks to benchmark the current state of the design and some of the rationale and analysis behind it. There are specific challenges to address when preparing a timely and effective design for the Exploration Flight Test (EFT-1), while still looking ahead and providing software extensibility for future exploration missions. The primary onboard measurements in a Near-Earth or Mid-Earth environment consist of GPS pseudo-range and delta-range, but for future explorations missions the use of star-tracker and optical navigation sources need to be considered. Discussions are presented for state size and composition, processing techniques, and consider states. A presentation is given for the processing technique using the computationally stable and robust UDU formulation with an Agee-Turner Rank-One update. This allows for computational savings when dealing with many parameters which are modeled as slowly varying Gauss-Markov processes. Preliminary analysis shows up to a 50% reduction in computation versus a more traditional formulation. Several state elements are discussed and evaluated, including position, velocity, attitude, clock bias/drift, and GPS measurement biases in addition to bias, scale factor, misalignment, and non-orthogonalities of the accelerometers and gyroscopes. Another consideration is the initialization of the EKF in various scenarios. Scenarios such as single-event upset, ground command, and cold start are discussed as are strategies for whole and partial state updates as well as covariance considerations. Strategies are given for dealing with latent measurements and high-rate propagation using multi-rate architecture. The details of the rate groups and the data ow between the elements is discussed and evaluated.

Impacts of mothers' occupation status and parenting styles on levels of self-control, addiction to computer games, and educational progress of adolescents.

Science.gov (United States)

Abedini, Yasamin; Zamani, Bibi Eshrat; Kheradmand, Ali; Rajabizadeh, Ghodratollah

2012-01-01

Addiction to computer (video) games in adolescents and its relationship with educational progress has recently attracted the attention of rearing and education experts as well as organizations and institutes involved in physical and mental health. The current research attempted to propose a structural model of the relationships between parenting styles, mothers' occupation status, and addiction to computer games, self-control, and educational progress of secondary school students. Using multistage cluster random sampling, 500 female and male secondary school students in Kerman (Iran) were selected and studied. The research tools included self-control, parenting styles, and addiction to computer games questionnaires and a self-made questionnaire containing demographic details. The data was analyzed using exploratory factor analysis, Cronbach's alpha coefficient and route analysis (in LISREL). We found self-control to have a linking role in the relationship between four parenting styles and educational progress. Mothers' occupation status was directly and significantly correlated with addiction to computer games. Although four parenting styles directly and significantly affected addiction to computer games, the findings did not support the linking role of addiction to computer games in the relationship between four parenting styles and educational progress. In agreement with previous studies, the current research reflected the impact of four parenting styles on self-control, addiction to computer games, and educational progress of students. Among the parenting styles, authoritative style can affect the severity of addiction to computer games through self-control development. It can thus indirectly influence the educational progress of students. Parents are recommended to use authoritative parenting style to help both self-management and psychological health of their children. The employed mothers are also recommended to have more supervision and control on the degree

Impacts of Mothers’ Occupation Status and Parenting Styles on Levels of Self-Control, Addiction to Computer Games, and Educational Progress of Adolescents

Science.gov (United States)

Abedini, Yasamin; Zamani, Bibi Eshrat; Kheradmand, Ali; Rajabizadeh, Ghodratollah

2012-01-01

Background Addiction to computer (video) games in adolescents and its relationship with educational progress has recently attracted the attention of rearing and education experts as well as organizations and institutes involved in physical and mental health. The current research attempted to propose a structural model of the relationships between parenting styles, mothers’ occupation status, and addiction to computer games, self-control, and educational progress of secondary school students. Methods Using multistage cluster random sampling, 500 female and male secondary school students in Kerman (Iran) were selected and studied. The research tools included self-control, parenting styles, and addiction to computer games questionnaires and a self-made questionnaire containing demographic details. The data was analyzed using exploratory factor analysis, Cronbach’s alpha coefficient and route analysis (in LISREL). Findings We found self-control to have a linking role in the relationship between four parenting styles and educational progress. Mothers’ occupation status was directly and significantly correlated with addiction to computer games. Although four parenting styles directly and significantly affected addiction to computer games, the findings did not support the linking role of addiction to computer games in the relationship between four parenting styles and educational progress. Conclusion In agreement with previous studies, the current research reflected the impact of four parenting styles on self-control, addiction to computer games, and educational progress of students. Among the parenting styles, authoritative style can affect the severity of addiction to computer games through self-control development. It can thus indirectly influence the educational progress of students. Parents are recommended to use authoritative parenting style to help both self-management and psychological health of their children. The employed mothers are also recommended to

Progress Toward Polio Eradication — Somalia, 1998–2013

Science.gov (United States)

Mbaeyi, Chukwuma; Kamadjeu, Raoul; Mahamud, Abdirahman; Webeck, Jenna; Ehrhardt, Derek; Mulugeta, Abraham

2015-01-01

Since the 1988 resolution of the World Health Assembly to eradicate polio, significant progress has been made toward achieving this goal, with the result that only Afghanistan, Nigeria, and Pakistan have never successfully interrupted endemic transmission of wild poliovirus. However, one of the greatest challenges of the Global Polio Eradication Initiative has been that of maintaining the polio-free status of countries in unstable regions with weak healthcare infrastructure, a challenge exemplified by Somalia, a country in the Horn of Africa region. Somalia interrupted indigenous transmission of wild poliovirus in 2002, four years after establishing its national polio eradication programme. But political instability and protracted armed conflict, with significant disruption of the healthcare system, left the country vulnerable to two subsequent imported outbreaks of wild poliovirus. The first occurred during 2005–2007, resulting in over 200 cases of paralytic polio, while the second importation in 2013 is currently ongoing. Despite immense challenges, the country has a sensitive surveillance system that has facilitated prompt detection of outbreaks, but its weak routine immunization system means that supplementary immunization activities constitute the primary strategy for reaching children with polio vaccines. Conducting vaccination campaigns in a setting of conflict has been at times hazardous but the country’s polio programme has demonstrated resilience in overcoming many obstacles to ensure that children receive life-saving polio vaccines. Regaining and maintaining Somalia’s polio-free status will, however, depend on finding innovative and lasting solutions to the challenge of administering vaccines in a setting of ongoing conflict and instability. PMID:25316833

The status of Thailand Y2K Progress

International Nuclear Information System (INIS)

Srisanan, V.; Junlanan, M.; Malaivongs, K.

1999-01-01

This report divided into two parts deals with the general status of Y2K issues in Thailand and its effects in nuclear safeguards and physical protection and control of nuclear materials. It includes a description of safeguards in Thailand, Y2K action plan, contingency (emergency) plan, Thailand Y2K status report and the Thailand answer sheet about safeguards Y2K problem

Alabama: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP, high school graduation rates, and access…

Virginia: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP, high school graduation rates, and access…

Florida: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP, high school graduation rates, and access…

Challenges and Recent Progress in the Development of a Closed-loop Artificial Pancreas.

Science.gov (United States)

Bequette, B Wayne

2012-12-01

Pursuit of a closed-loop artificial pancreas that automatically controls the blood glucose of individuals with type 1 diabetes has intensified during the past six years. Here we discuss the recent progress and challenges in the major steps towards a closed-loop system. Continuous insulin infusion pumps have been widely available for over two decades, but "smart pump" technology has made the devices easier to use and more powerful. Continuous glucose monitoring (CGM) technology has improved and the devices are more widely available. A number of approaches are currently under study for fully closed-loop systems; most manipulate only insulin, while others manipulate insulin and glucagon. Algorithms include on-off (for prevention of overnight hypoglycemia), proportional-integral-derivative (PID), model predictive control (MPC) and fuzzy logic based learning control. Meals cause a major "disturbance" to blood glucose, and we discuss techniques that our group has developed to predict when a meal is likely to be consumed and its effect. We further examine both physiology and device-related challenges, including insulin infusion set failure and sensor signal attenuation. Finally, we discuss the next steps required to make a closed-loop artificial pancreas a commercial reality.

Challenges in the evaluation of urinary iodine status in pregnancy

DEFF Research Database (Denmark)

Andersen, Stine Linding; Sørensen, Louise Kolding; Motavaf, Anne Krejbjerg

2014-01-01

Objectives: Median urinary iodine concentration (UIC) is the recommended method to evaluate iodine status in pregnancy, but several factors may challenge the interpretation of the results. We evaluated UIC in pregnant women according to (1) sampling in the hospital versus at home, (2) time...... of the most recent iodine supplement intake prior to sampling, and (3) members of their household. Study Design: Danish crosssectional study in the year 2012. Pregnant women (n = 158), their male partners (n = 157) and children (n = 51) provided a questionnaire with detailed information on iodine supplement.......042), but not estimated 24-hour urinary iodine excretion (p = 0.79), were higher when sampling was at home. Median UIC was dependent on the time of the most recent iodine supplement intake prior to sampling [same day (n = 79): 150 μg/l (95% CI 131-181 μg/l), the day before (n = 51): 105 μg/l (78-131 μg/l), several days...

Progress and challenges in the development and qualification of multi-level multi-physics coupled methodologies for reactor analysis

International Nuclear Information System (INIS)

Ivanov, K.; Avramova, M.

2007-01-01

Current trends in nuclear power generation and regulation as well as the design of next generation reactor concepts along with the continuing computer technology progress stimulate the development, qualification and application of multi-physics multi-scale coupled code systems. The efforts have been focused on extending the analysis capabilities by coupling models, which simulate different phenomena or system components, as well as on refining the scale and level of detail of the coupling. This paper reviews the progress made in this area and outlines the remaining challenges. The discussion is illustrated with examples based on neutronics/thermohydraulics coupling in the reactor core modeling. In both fields recent advances and developments are towards more physics-based high-fidelity simulations, which require implementation of improved and flexible coupling methodologies. First, the progresses in coupling of different physics codes along with the advances in multi-level techniques for coupled code simulations are discussed. Second, the issues related to the consistent qualification of coupled multi-physics and multi-scale code systems for design and safety evaluation are presented. The increased importance of uncertainty and sensitivity analysis are discussed along with approaches to propagate the uncertainty quantification between the codes. The incoming OECD LWR Uncertainty Analysis in Modeling (UAM) benchmark is the first international activity to address this issue and it is described in the paper. Finally, the remaining challenges with multi-physics coupling are outlined. (authors)

Progress and challenges in the development and qualification of multi-level multi-physics coupled methodologies for reactor analysis

Energy Technology Data Exchange (ETDEWEB)

Ivanov, K.; Avramova, M. [Pennsylvania State Univ., University Park, PA (United States)

2007-07-01

Current trends in nuclear power generation and regulation as well as the design of next generation reactor concepts along with the continuing computer technology progress stimulate the development, qualification and application of multi-physics multi-scale coupled code systems. The efforts have been focused on extending the analysis capabilities by coupling models, which simulate different phenomena or system components, as well as on refining the scale and level of detail of the coupling. This paper reviews the progress made in this area and outlines the remaining challenges. The discussion is illustrated with examples based on neutronics/thermohydraulics coupling in the reactor core modeling. In both fields recent advances and developments are towards more physics-based high-fidelity simulations, which require implementation of improved and flexible coupling methodologies. First, the progresses in coupling of different physics codes along with the advances in multi-level techniques for coupled code simulations are discussed. Second, the issues related to the consistent qualification of coupled multi-physics and multi-scale code systems for design and safety evaluation are presented. The increased importance of uncertainty and sensitivity analysis are discussed along with approaches to propagate the uncertainty quantification between the codes. The incoming OECD LWR Uncertainty Analysis in Modeling (UAM) benchmark is the first international activity to address this issue and it is described in the paper. Finally, the remaining challenges with multi-physics coupling are outlined. (authors)

Ensuring good nutritional status in patients with Parkinson's disease: challenges and solutions

Directory of Open Access Journals (Sweden)

Baroni L

2014-12-01

Full Text Available Luciana Baroni,1 Cristina Zuliani2 1Primary Care Unit, Northern District, Azienda ULSS 9 Treviso, Italy; 2Department of Neurology, General Hospital, Mirano, Venice, Italy Abstract: Nutrition is becoming an important tool in the management of the main chronic diseases, including Parkinson's disease (PD. Nutritional status has been shown to deteriorate with the progression of PD, due to motor and nonmotor complications. Dietary protein can reduce the effectiveness of levodopa treatment in PD patients, since the large neutral amino acids and levodopa share the same saturated carrier system, while fiber can improve the drug bioavailability. Moreover, nutrition seems to be directly involved in PD risk: high dietary intakes of animal fat, iron, mercury, and dairy, as well as western dietary patterns can increase it, while intake of some antioxidant compounds and plant-based dietary patterns can be protective. The means of ensuring good nutritional status in PD range from providing adequate energy and nutrients for the body, to considering in a broader perspective, the management of motor and nonmotor symptoms and chronic levodopa treatment complications, as well as pursuing potential neuroprotection. This review summarizes the most relevant results in the literature, and discusses the contribution of diet in the management of PD. Keywords: levodopa, Mediterranean diet, plant-based diet, protein-redistribution diet, vegetarian diet

Progress toward polio eradication--Somalia, 1998-2013.

Science.gov (United States)

Mbaeyi, Chukwuma; Kamadjeu, Raoul; Mahamud, Abdirahman; Webeck, Jenna; Ehrhardt, Derek; Mulugeta, Abraham

2014-11-01

Since the 1988 resolution of the World Health Assembly to eradicate polio, significant progress has been made toward achieving this goal, with the result that only Afghanistan, Nigeria, and Pakistan have never successfully interrupted endemic transmission of wild poliovirus. However, one of the greatest challenges of the Global Polio Eradication Initiative has been that of maintaining the polio-free status of countries in unstable regions with weak healthcare infrastructure, a challenge exemplified by Somalia, a country in the Horn of Africa region. Somalia interrupted indigenous transmission of wild poliovirus in 2002, 4 years after the country established its national polio eradication program. But political instability and protracted armed conflict, with significant disruption of the healthcare system, have left Somalia vulnerable to 2 imported outbreaks of wild poliovirus. The first occurred during 2005-2007, resulting in >200 cases of paralytic polio, whereas the second, which began in 2013, is currently ongoing. Despite immense challenges, the country has a sensitive surveillance system that has facilitated prompt detection of outbreaks, but its weak routine immunization system means that supplementary immunization activities constitute the primary strategy for reaching children with polio vaccines. Conducting vaccination campaigns in a setting of conflict has been at times hazardous, but the country's polio program has demonstrated resilience in overcoming many obstacles to ensure that children receive lifesaving polio vaccines. Regaining and maintaining Somalia's polio-free status will depend on finding innovative and lasting solutions to the challenge of administering vaccines in a setting of ongoing conflict and instability. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

QUALITY ASSURANCE IN SECONDARY EDUCATION PROGRAME OF BANGLADESH OPEN UNIVERSITY: Present Status and Challenges

Directory of Open Access Journals (Sweden)

Zobaida AKHTER

2008-04-01

Full Text Available In the present day in national and international perspectives, quality is the top of most agendas. Quality of education has significant impact and invaluable contribution to the area of development. Recently, the SSC & HSC program of BOU have earned recognition of equivalency with the formal education sector, which has naturally raised the question of quality assurance of these programs By applying the quantitative method, the study has assessed the present status of the quality of SSC & HSC program of BOU and also put some recommendations to meet the challenges for further development.

Progress and challenges of engineering a biophysical CO2-concentrating mechanism into higher plants.

Science.gov (United States)

Rae, Benjamin D; Long, Benedict M; Förster, Britta; Nguyen, Nghiem D; Velanis, Christos N; Atkinson, Nicky; Hee, Wei Yih; Mukherjee, Bratati; Price, G Dean; McCormick, Alistair J

2017-06-01

Growth and productivity in important crop plants is limited by the inefficiencies of the C3 photosynthetic pathway. Introducing CO2-concentrating mechanisms (CCMs) into C3 plants could overcome these limitations and lead to increased yields. Many unicellular microautotrophs, such as cyanobacteria and green algae, possess highly efficient biophysical CCMs that increase CO2 concentrations around the primary carboxylase enzyme, Rubisco, to enhance CO2 assimilation rates. Algal and cyanobacterial CCMs utilize distinct molecular components, but share several functional commonalities. Here we outline the recent progress and current challenges of engineering biophysical CCMs into C3 plants. We review the predicted requirements for a functional biophysical CCM based on current knowledge of cyanobacterial and algal CCMs, the molecular engineering tools and research pipelines required to translate our theoretical knowledge into practice, and the current challenges to achieving these goals. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Progress and status of the integral fast reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1993-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. The Integral Fast Reactor (IFR) fuel cycle, is based on the use of a metallic fuel alloy (U-Pu-Zr) that permits use of an innovative method for processing of spent fuel. This method, a combination of pyrometallurgical and electrochemical processes, has been termed pyroprocessing. It offers the advantages of a simple, compact processing system and limited volumes of stabilized high-level wastes. This translates to an economically viable system that is likely to receive favorable public response, particularly when combined with the other attributes of the Integral Fast Reactor. Substantial progress has been made in the development of the IFR pyroprocessing method. A comprehensive demonstration of the process will soon begin at the Argonne National Laboratory Idaho site, using spent fuel from the EBR-II reactor. An important advantage of the IFR is its ability to recycle fuel in the process of power generation, extending fuel resources by a considerable amount and assuring the continued viability of nuclear power stations by reducing dependence on external fuel supplies. Pyroprocessing is the means whereby the recycle process is accomplished. It can also be applied to the recovery of fuel constituents from spent fuel generated in the process of operation of conventional light water reactor power plants, offering the means to recover the valuable fuel resources remaining in that material

Nanoparticle-Based Drug Delivery for Therapy of Lung Cancer: Progress and Challenges

Directory of Open Access Journals (Sweden)

Anish Babu

2013-01-01

Full Text Available The last decade has witnessed enormous advances in the development and application of nanotechnology in cancer detection, diagnosis, and therapy culminating in the development of the nascent field of “cancer nanomedicine.” A nanoparticle as per the National Institutes of Health (NIH guidelines is any material that is used in the formulation of a drug resulting in a final product smaller than 1 micron in size. Nanoparticle-based therapeutic systems have gained immense popularity due to their ability to overcome biological barriers, effectively deliver hydrophobic therapies, and preferentially target disease sites. Currently, many formulations of nanocarriers are utilized including lipid-based, polymeric and branched polymeric, metal-based, magnetic, and mesoporous silica. Innovative strategies have been employed to exploit the multicomponent, three-dimensional constructs imparting multifunctional capabilities. Engineering such designs allows simultaneous drug delivery of chemotherapeutics and anticancer gene therapies to site-specific targets. In lung cancer, nanoparticle-based therapeutics is paving the way in the diagnosis, imaging, screening, and treatment of primary and metastatic tumors. However, translating such advances from the bench to the bedside has been severely hampered by challenges encountered in the areas of pharmacology, toxicology, immunology, large-scale manufacturing, and regulatory issues. This review summarizes current progress and challenges in nanoparticle-based drug delivery systems, citing recent examples targeted at lung cancer treatment.

Progression of vestibular schawnnoma after GammaKnife radiosurgery: A challenge for microsurgical resection.

Science.gov (United States)

Aboukaïs, Rabih; Bonne, Nicolas-Xavier; Touzet, Gustavo; Vincent, Christophe; Reyns, Nicolas; Lejeune, Jean-Paul

2018-05-01

We aimed to evaluate the outcome of patients who underwent salvage microsurgery for vestibular schwannoma (VS) that failed primary Gammaknife radiosurgery (GKS). Among the 1098 patients who received GKS for the treatment of VS in our center between January 2004 and December 2012, the follow-up was organized in our institution for 290 patients who lived in our recruitment area. Tumor progression was noted in 23 patients. A salvage microsurgical resection was performed in 11 patients, who were included in our study. Grading of facial function was done according to the House & Brackman scale. The mean age at diagnosis was 50.2 years (19-68 years) and the mean follow-up was 9.4 years (4-13 years). The mean dose was 11.8 Gy (11-12 Gy) and the mean volume was 922 mm3 (208-2500 mm3). The mean period between GKS and diagnosis of tumor progression was 32 months (18-72 months). Concerning salvage microsurgery, complete resection was obtained in 8 patients. Small residual tumor on the facial nerve was deliberately left in 3 patients and no tumor progression was noted with a mean follow-up of 26 months. At last follow-up, facial nerve function was grade 1 in 4 patients, grade 2 in 3 patients, grade 3 in 1 patient and grade 4 in 3 patients. Salvage surgery of recurrent vestibular schwannoma after failed initial GKS remains a good treatment. However, facial nerve preservation is more challenging in this case and small tumor remnant could be sometimes deliberately left. Copyright © 2018 Elsevier B.V. All rights reserved.

Water quality status and trends in the United States

Science.gov (United States)

Larsen, Matthew C.; Hamilton, Pixie A.; Werkheiser, William H.; Ahuja, Satinder

2013-01-01

Information about water quality is vital to ensure long-term availability and sustainability of water that is safe for drinking and recreation and suitable for industry, irrigation, fish, and wildlife. Protecting and enhancing water quality is a national priority, requiring information on water-quality status and trends, progress toward clean water standards, continuing problems, and emerging challenges. In this brief review, we discuss U.S. Geological Survey assessments of nutrient pollution, pesticides, mixtures of organic wastewater compounds (known as emerging contaminants), sediment-bound contaminants (like lead and DDT), and mercury, among other contaminants. Additionally, aspects of land use and current and emerging challenges associated with climate change are presented. Climate change must be considered, as water managers continue their efforts to maintain sufficient water of good quality for humans and for the ecosystem.

North Carolina: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

West Virginia: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

South Carolina: Taking Stock and Pushing Forward. 2014 State Progress Report on the Challenge to Lead 2020, Goals for Education

Science.gov (United States)

Southern Regional Education Board (SREB), 2014

2014-01-01

"Taking Stock and Pushing Forward" (2014) reports states' progress toward the Challenge to Lead 2020 Goals for Education. State-specific documents report on student achievement as well as essential state policies to improve it. Among the many metrics: how states are improving achievement on NAEP [National Assessment of Educational…

HbA1C variability and the risk of renal status progression in Diabetes Mellitus: a meta-analysis.

Directory of Open Access Journals (Sweden)

Dongsheng Cheng

Full Text Available To explore the association between glycated hemoglobin (A1C variability and renal disease progression in patients with diabetes mellitus.A comprehensive search was performed using the PubMed and Embase databases (up to April 26, 2014. The hazard ratio (HR was pooled per unit increase in the standard deviation of A1C (A1C-SD to evaluate the dose-response relationship between A1C-SD and the risk of nephropathy.Eight studies with a total of 17,758 subjects provided the HR for A1C-SD and were included in the final meta-analysis. The pooled HR results demonstrated that A1C-SD was significantly associated with the progression of renal status (HR for both T1DM and T2DM 1.43, 95% confidence interval [CI] 1.24-1.64; HR for T1DM 1.70, 95%CI 1.41-2.05; HR for T2DM 1.20, 95%CI 1.12-1.28. A1C-SD was significantly correlated with new-onset microalbuminuria (HR for T1DM 1.63, 95%CI 1.28-2.07; HR for T2DM 1.23, 95%CI 1.08-1.39. These outcomes were also supported in subgroup analyses. Furthermore, sensitivity analyses demonstrated that the results were robust.A1C variability is independently associated with the development of microalbuminuria and the progression of renal status in both type 1 and 2 diabetes patients. A standard method for measuring A1C variability is essential for further and deeper analyses. In addition, future studies should assess the effect of reducing A1C variability on nephropathy complication.

Label-free SERS in biological and biomedical applications: Recent progress, current challenges and opportunities

Science.gov (United States)

Zheng, Xiao-Shan; Jahn, Izabella Jolan; Weber, Karina; Cialla-May, Dana; Popp, Jürgen

2018-05-01

To achieve an insightful look within biomolecular processes on the cellular level, the development of diseases as well as the reliable detection of metabolites and pathogens, a modern analytical tool is needed that is highly sensitive, molecular-specific and exhibits fast detection. Surface-enhanced Raman spectroscopy (SERS) is known to meet these requirements and, within this review article, the recent progress of label-free SERS in biological and biomedical applications is summarized and discussed. This includes the detection of biomolecules such as metabolites, nucleic acids and proteins. Further, the characterization and identification of microorganisms has been achieved by label-free SERS-based approaches. Eukaryotic cells can be characterized by SERS in order to gain information about the outer cell wall or to detect intracellular molecules and metabolites. The potential of SERS for medically relevant detection schemes is emphasized by the label-free detection of tissue, the investigation of body fluids as well as applications for therapeutic and illicit drug monitoring. The review article is concluded with an evaluation of the recent progress and current challenges in order to highlight the direction of label-free SERS in the future.

Interdependence of plant water status with photosynthetic performance and root defense responses in Vigna radiata (L.) Wilczek under progressive drought stress and recovery.

Science.gov (United States)

Sengupta, Debashree; Guha, Anirban; Reddy, Attipalli Ramachandra

2013-10-05

The present study investigates the interdependence of plant water status with foliar and root responses in Vigna radiata L.Wilczek under progressive drought. Vegetatively-mature V. radiata plants were subjected to water withdrawal for 3 and 6days (D3 and D6, respectively) and then re-watered subsequently for 6days (6R) for stress-recovery. Changes in plant water status were expressed in terms of leaf and root moisture contents (LMC and RMC, respectively) and leaf relative water content (LRWC). Progressive drought caused apparent decrease in LRWC, LMC and RMC depicting significant level of dehydration of leaf and root tissues. Stomatal limitation alone could not account for the observed decrease in net CO2 assimilation rates (Pn) due to comparatively less decrease in sub-stomatal CO2 (Ci) concentrations with respect to other gas exchange parameters indicating possible involvement of non-stomatal limitations. Analysis of polyphasic chl a fluorescence kinetics during progressive drought showed decreased energy connectivity among PSII units as defined by a positive L-band with highest amplitude during D6. Efficiency of electron flux from OEC towards PSII acceptor side was not significantly affected during drought conditions as evidenced by the absence of a positive K-band. Increasing root-level water-limitation enforced a gradual oxidative stress through H2O2 accumulation and membrane lipid peroxidation in V. radiata roots exhibiting drastic enhancement of proline content and a significant but gradual increase in ascorbic acid content as well as guaiacol peroxidase activity under progressive drought. Expression analysis of Δ(1) pyrroline-5-carboxylate synthetase (P5CS) through real time PCR and enzyme activity studies showed a strong positive correlation between VrP5CS gene expression, enzyme activity and proline accumulation in the roots of V. radiata under progressive drought and recovery. Drought-induced changes in root moisture content (RMC) showed positive linear

Orion Absolute Navigation System Progress and Challenges

Science.gov (United States)

Holt, Greg N.; D'Souza, Christopher

2011-01-01

The Orion spacecraft is being designed as NASA's next-generation exploration vehicle for crewed missions beyond Low-Earth Orbit. The navigation system for the Orion spacecraft is being designed in a Multi-Organizational Design Environment (MODE) team including contractor and NASA personnel. The system uses an Extended Kalman Filter to process measurements and determine the state. The design of the navigation system has undergone several iterations and modifications since its inception, and continues as a work-in-progress. This paper seeks to benchmark the current state of the design and some of the rationale and analysis behind it. There are specific challenges to address when preparing a timely and effective design for the Exploration Flight Test (EFT-1), while still looking ahead and providing software extensibility for future exploration missions. The primary measurements in a Near-Earth or Mid-Earth environment consist of GPS pseudorange and deltarange, but for future explorations missions the use of star-tracker and optical navigation sources need to be considered. Discussions are presented for state size and composition, processing techniques, and consider states. A presentation is given for the processing technique using the computationally stable and robust UDU formulation with an Agee-Turner Rank-One update. This allows for computational savings when dealing with many parameters which are modeled as slowly varying Gauss-Markov processes. Preliminary analysis shows up to a 50% reduction in computation versus a more traditional formulation. Several state elements are discussed and evaluated, including position, velocity, attitude, clock bias/drift, and GPS measurement biases in addition to bias, scale factor, misalignment, and non-orthogonalities of the accelerometers and gyroscopes. Another consideration is the initialization of the EKF in various scenarios. Scenarios such as single-event upset, ground command, pad alignment, cold start are discussed as are

The uranium industry in the former eastern block countries-present status and new challenges associated with remediation work

International Nuclear Information System (INIS)

Vels, B.Dr.; Ruhrmann, G.Dr.

1994-01-01

The main uranium producing countries and the individual production centres are briefly described, including their production status. In particular, an analysis of their present situation is given. The challenge of required remediation work lies in the successful handling of the complex transformation from the old to the new socio-economic environment within a tight financial framework

CANDU Safety R&D Status, Challenges, and Prospects in Canada

Directory of Open Access Journals (Sweden)

W. Shen

2015-01-01

Full Text Available In Canada, safe operation of CANDU (CANada Deuterium Uranium; it is a registered trademark of Atomic Energy of Canada Limited reactors is supported by a full-scope program of nuclear safety research and development (R&D in key technical areas. Key nuclear R&D programs, facilities, and expertise are maintained in order to address the unique features of the CANDU as well as generic technology areas common to CANDU and LWR (light water reactor. This paper presents an overview of the CANDU safety R&D which includes background, drivers, current status, challenges, and future directions. This overview of the Canadian nuclear safety R&D programs includes those currently conducted by the COG (CANDU Owners Group, AECL (Atomic Energy of Canada Limited, Candu Energy Inc., and the CNSC (Canadian Nuclear Safety Commission and by universities via UNENE (University Network of Excellence in Nuclear Engineering sponsorship. In particular, the nuclear safety R&D program related to the emerging CANDU ageing issues is discussed. The paper concludes by identifying directions for the future nuclear safety R&D.

Real-Time Monitoring of Critical Care Analytes in the Bloodstream with Chemical Sensors: Progress and Challenges.

Science.gov (United States)

Frost, Megan C; Meyerhoff, Mark E

2015-01-01

We review approaches and challenges in developing chemical sensor-based methods to accurately and continuously monitor levels of key analytes in blood related directly to the status of critically ill hospitalized patients. Electrochemical and optical sensor-based technologies have been pursued to measure important critical care species in blood [i.e., oxygen, carbon dioxide, pH, electrolytes (K(+), Na(+), Cl(-), etc.), glucose, and lactate] in real-time or near real-time. The two main configurations examined to date for achieving this goal have been intravascular catheter sensors and patient attached ex vivo sensors with intermittent blood sampling via an attached indwelling catheter. We discuss the status of these configurations and the main issues affecting the accuracy of the measurements, including cell adhesion and thrombus formation on the surface of the sensors, sensor drift, sensor selectivity, etc. Recent approaches to mitigate these nagging performance issues that have prevented these technologies from clinical use are also discussed.

Focal status epilepticus and progressive dyskinesia: A novel phenotype for glycine receptor antibody-mediated neurological disease in children.

Science.gov (United States)

Chan, D W S; Thomas, T; Lim, M; Ling, S; Woodhall, M; Vincent, A

2017-03-01

Antibody-associated disorders of the central nervous system are increasingly recognised in adults and children. Some are known to be paraneoplastic, whereas in others an infective trigger is postulated. They include disorders associated with antibodies to N-methyl-d-aspartate receptor (NMDAR), voltage-gated potassium channel-complexes (VGKC-complex), GABA B receptor or glycine receptor (GlyR). With antibodies to NMDAR or VGKC-complexes, distinct clinical patterns are well characterised, but as more antibodies are discovered, the spectra of associated disorders are evolving. GlyR antibodies have been detected in patients with progressive encephalopathy with rigidity and myoclonus (PERM), or stiff man syndrome, both rare but disabling conditions. We report a case of a young child with focal seizures and progressive dyskinesia in whom GlyR antibodies were detected. Anticonvulsants and immunotherapy were effective in treating both the seizures and movement disorder with good neurological outcome and with a decline in the patient's serum GlyR-Ab titres. Glycine receptor antibodies are associated with focal status epilepticus and seizures, encephalopathy and progressive dyskinesia and should be evaluated in autoimmune encephalitis. Copyright © 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Health care in China: improvement, challenges, and reform.

Science.gov (United States)

Wang, Chen; Rao, Keqin; Wu, Sinan; Liu, Qian

2013-02-01

Over the past 2 decades, significant progress has been made in improving the health-care system and people's health conditions in China. Following rapid economic growth and social development, China's health-care system is facing new challenges, such as increased health-care demands and expenditure, inefficient use of health-care resources, unsatisfying implementation of disease management guidelines, and inadequate health-care insurance. Facing these challenges, the Chinese government carried out a national health-care reform in 2009. A series of policies were developed and implemented to improve the health-care insurance system, the medical care system, the public health service system, the pharmaceutical supply system, and the health-care institution management system in China. Although these measures have shown promising results, further efforts are needed to achieve the ultimate goal of providing affordable and high-quality care for both urban and rural residents in China. This article not only covers the improvement, challenges, and reform of health care in general in China, but also highlights the status of respiratory medicine-related issues.

Acute Pancreatitis—Progress and Challenges

Science.gov (United States)

Afghani, Elham; Pandol, Stephen J.; Shimosegawa, Tooru; Sutton, Robert; Wu, Bechien U.; Vege, Santhi Swaroop; Gorelick, Fred; Hirota, Morihisa; Windsor, John; Lo, Simon K.; Freeman, Martin L.; Lerch, Markus M.; Tsuji, Yoshihisa; Melmed, Gil Y.; Wassef, Wahid; Mayerle, Julia

2016-01-01

An international symposium entitled “Acute pancreatitis: progress and challenges” was held on November 5, 2014 at the Hapuna Beach Hotel, Big Island, Hawaii, as part of the 45th Anniversary Meeting of the American Pancreatic Association and the Japanese Pancreas Society. The course was organized and directed by Drs. Stephen Pandol, Tooru Shimosegawa, Robert Sutton, Bechien Wu, and Santhi Swaroop Vege. The symposium objectives were to: (1) highlight current issues in management of acute pancreatitis, (2) discuss promising treatments, (3) consider development of quality indicators and improved measures of disease activity, and (4) present a framework for international collaboration for development of new therapies. This article represents a compilation and adaptation of brief summaries prepared by speakers at the symposium with the purpose of broadly disseminating information and initiatives. PMID:26465949

Recent progress and new challenges in isospin physics with heavy-ion reactions

Energy Technology Data Exchange (ETDEWEB)

Li Baoan [Department of Physics, Texas A and M University-Commerce, Commerce, TX 75429-3011 (United States)], E-mail: Bao-An_Li@Tamu-Commerce.edu; Chen Liewen [Institute of Theoretical Physics, Shanghai Jiao Tong University, Shanghai 200240 (China)], E-mail: Lwchen@Sjtu.edu.cn; Ko, Che Ming [Cyclotron Institute and Physics Department, Texas A and M University, College Station, TX 77843-3366 (United States)], E-mail: Ko@Comp.tamu.edu

2008-08-15

The ultimate goal of studying isospin physics via heavy-ion reactions with neutron-rich, stable and/or radioactive nuclei is to explore the isospin dependence of in-medium nuclear effective interactions and the equation of state of neutron-rich nuclear matter, particularly the isospin-dependent term in the equation of state, i.e., the density dependence of the symmetry energy. Because of its great importance for understanding many phenomena in both nuclear physics and astrophysics, the study of the density dependence of the nuclear symmetry energy has been the main focus of the intermediate-energy heavy-ion physics community during the last decade, and significant progress has been achieved both experimentally and theoretically. In particular, a number of phenomena or observables have been identified as sensitive probes to the density dependence of nuclear symmetry energy. Experimental studies have confirmed some of these interesting isospin-dependent effects and allowed us to constrain relatively stringently the symmetry energy at sub-saturation densities. The impact of this constrained density dependence of the symmetry energy on the properties of neutron stars have also been studied, and they were found to be very useful for the astrophysical community. With new opportunities provided by the various radioactive beam facilities being constructed around the world, the study of isospin physics is expected to remain one of the forefront research areas in nuclear physics. In this report, we review the major progress achieved during the last decade in isospin physics with heavy ion reactions and discuss future challenges to the most important issues in this field.

Geothermal progress monitor report No. 6

Energy Technology Data Exchange (ETDEWEB)

1982-06-01

Geothermal Progress Monitor Report No. 6 presents a state-by-state summary of the status of geothermal leasing, exploration, and development in major physiographic regions where geothermal resource potential has been identified. Recent state-specific activities are reported at the end of each state status report, while recent activities of a more general nature are summarized briefly in Part II of the report. A list of recent publications of potential interest to the geothermal community and a directory of contributors to the geothermal progress monitoring system are also included.

Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech.

Science.gov (United States)

Whitwell, Jennifer L; Weigand, Stephen D; Duffy, Joseph R; Strand, Edythe A; Machulda, Mary M; Senjem, Matthew L; Gunter, Jeffrey L; Lowe, Val J; Jack, Clifford R; Josephs, Keith A

2016-01-01

Beta-amyloid (Aβ) deposition can be observed in primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS). While it is typically associated with logopenic PPA, there are exceptions that make predicting Aβ status challenging based on clinical diagnosis alone. We aimed to determine whether MRI regional volumes or clinical data could help predict Aβ deposition. One hundred and thirty-nine PPA (n = 97; 15 agrammatic, 53 logopenic, 13 semantic and 16 unclassified) and PAOS (n = 42) subjects were prospectively recruited into a cross-sectional study and underwent speech/language assessments, 3.0 T MRI and C11-Pittsburgh Compound B PET. The presence of Aβ was determined using a 1.5 SUVR cut-point. Atlas-based parcellation was used to calculate gray matter volumes of 42 regions-of-interest across the brain. Penalized binary logistic regression was utilized to determine what combination of MRI regions, and what combination of speech and language tests, best predicts Aβ (+) status. The optimal MRI model and optimal clinical model both performed comparably in their ability to accurately classify subjects according to Aβ status. MRI accurately classified 81% of subjects using 14 regions. Small left superior temporal and inferior parietal volumes and large left Broca's area volumes were particularly predictive of Aβ (+) status. Clinical scores accurately classified 83% of subjects using 12 tests. Phonological errors and repetition deficits, and absence of agrammatism and motor speech deficits were particularly predictive of Aβ (+) status. In comparison, clinical diagnosis was able to accurately classify 89% of subjects. However, the MRI model performed well in predicting Aβ deposition in unclassified PPA. Clinical diagnosis provides optimum prediction of Aβ status at the group level, although regional MRI measurements and speech and language testing also performed well and could have advantages in predicting Aβ status in unclassified PPA subjects.

Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech

Directory of Open Access Journals (Sweden)

Jennifer L. Whitwell

2016-01-01

Full Text Available Beta-amyloid (Aβ deposition can be observed in primary progressive aphasia (PPA and progressive apraxia of speech (PAOS. While it is typically associated with logopenic PPA, there are exceptions that make predicting Aβ status challenging based on clinical diagnosis alone. We aimed to determine whether MRI regional volumes or clinical data could help predict Aβ deposition. One hundred and thirty-nine PPA (n = 97; 15 agrammatic, 53 logopenic, 13 semantic and 16 unclassified and PAOS (n = 42 subjects were prospectively recruited into a cross-sectional study and underwent speech/language assessments, 3.0 T MRI and C11-Pittsburgh Compound B PET. The presence of Aβ was determined using a 1.5 SUVR cut-point. Atlas-based parcellation was used to calculate gray matter volumes of 42 regions-of-interest across the brain. Penalized binary logistic regression was utilized to determine what combination of MRI regions, and what combination of speech and language tests, best predicts Aβ (+ status. The optimal MRI model and optimal clinical model both performed comparably in their ability to accurately classify subjects according to Aβ status. MRI accurately classified 81% of subjects using 14 regions. Small left superior temporal and inferior parietal volumes and large left Broca's area volumes were particularly predictive of Aβ (+ status. Clinical scores accurately classified 83% of subjects using 12 tests. Phonological errors and repetition deficits, and absence of agrammatism and motor speech deficits were particularly predictive of Aβ (+ status. In comparison, clinical diagnosis was able to accurately classify 89% of subjects. However, the MRI model performed well in predicting Aβ deposition in unclassified PPA. Clinical diagnosis provides optimum prediction of Aβ status at the group level, although regional MRI measurements and speech and language testing also performed well and could have advantages in predicting Aβ status in unclassified

Status and issues of the European contribution to ITER

International Nuclear Information System (INIS)

Bindslev, H.

2015-01-01

Highlights: • We describe the technical status of F4E's contributions to the ITER International Fusion Energy Project. • The foundations of the ITER Tokamak Complex have been completed. • We describe the production of the Toroidal Field coils and the achieved accuracy. • The first stage of ITER's pre-qualification programme for the ITER first wall panels was completed. • Technical developments for several other ITER components are described. - Abstract: Fusion for Energy (F4E), on behalf of Europe, is responsible for the procurement of most of the high-technology items for the ITER device. This paper provides an overview of the technical status of Europe's contributions to ITER and the related challenges. In particular, we report on progress in the construction of the buildings at the Cadarache site, the fabrication of the superconducting magnets and the vacuum vessel and the testing and qualification of the in-vessel components (first wall and divertor). The status of the design and development of the additional heating systems and the test blanket modules will also be described.

Progress towards a global nuclear liability regime

International Nuclear Information System (INIS)

2014-01-01

During its April 2014 meeting, the Steering Committee for Nuclear Energy held a policy debate on 'Progress towards a Global Nuclear Liability Regime'. The Steering Committee heard presentations from several experts on nuclear liability issues. To prepare the delegates to the Steering Committee for the policy debate, the NEA Secretariat prepared a background note on the status of the nuclear liability regimes, as well as on current issues and challenges in implementing the regimes. This article is based on the background note and is intended to provide basic information on the relevant international conventions and an overview of recent developments to enhance the understanding of the legal framework in which policy-makers and practitioners are engaging to respond to the call for broader adherence to the international liability instruments. (authors)

Fuel Cell Buses in U.S. Transit Fleets: Current Status 2010

Energy Technology Data Exchange (ETDEWEB)

Eudy, L.; Chandler, K.; Gigakis, C.

2010-11-01

This status report, fourth in a series of annual status reports from the U.S. Department of Energy's National Renewable Energy Laboratory, summarizes progress and accomplishments from demonstrations of fuel cell transit buses in the United States. This year's assessment report provides the results from the fifth year of operation of five Van Hool, ISE, and UTC Power fuel cell buses operating at AC Transit, SunLine, and CTTRANSIT. The achievements and challenges of this bus design, implementation, and operating are presented, with a focus on the next steps for implementing larger numbers and new and different designs of fuel cell buses. The major positive result from nearly five years of operation is the dramatic increase in reliability experienced for the fuel cell power system.

Status and progress of the RERTR Program

International Nuclear Information System (INIS)

Travelli, A.

1996-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. The major events, findings, and activities of 1996 are reviewed after a brief summary of the results which the RERTR Program had achieved by the end of 1995 in collaboration with its many international partners

Status and progress of the RERTR Program

International Nuclear Information System (INIS)

Travelli, A.

1993-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. The major events, findings, and activities of 1993 are reviewed after a brief summary of the results which the RERTR Program had achieved by the end of 1992 in collaboration with its many international partners

Neutrino experiments: Status, recent progress, and prospects

International Nuclear Information System (INIS)

Brice, S

2008-01-01

Neutrino physics has seen an explosion of activity and new results in the last decade. In this report the current state of the field is summarized, with a particular focus on progress in the last two years. Prospects for the near term (roughly 5 years) are also described

Use of the Progressive Aphasia Severity Scale (PASS) in monitoring speech and language status in PPA

Science.gov (United States)

Sapolsky, Daisy; Domoto-Reilly, Kimiko; Dickerson, Bradford C.

2014-01-01

Background Primary progressive aphasia (PPA) is a devastating neurodegenerative syndrome involving the gradual development of aphasia, slowly impairing the patient’s ability to communicate. Pharmaceutical treatments do not currently exist and intervention often focuses on speech-language behavioral therapies, although further investigation is warranted to determine how best to harness functional benefits. Efforts to develop pharmaceutical and behavioral treatments have been hindered by a lack of standardized methods to monitor disease progression and treatment efficacy. Aims Here we describe our current approach to monitoring progression of PPA, including the development and applications of a novel clinical instrument for this purpose, the Progressive Aphasia Severity Scale (PASS). We also outline some of the issues related to initial evaluation and longitudinal monitoring of PPA. Methods & Procedures In our clinical and research practice we perform initial and follow-up assessments of PPA patients using a multi-faceted approach. In addition to standardized assessment measures, we use the PASS to rate presence and severity of symptoms across distinct domains of speech, language, and functional and pragmatic aspects of communication. Ratings are made using the clinician’s best judgment, integrating information from patient test performance in the office as well as a companion’s description of routine daily functioning. Outcomes & Results Monitoring symptom characteristics and severity with the PASS can assist in developing behavioral therapies, planning treatment goals, and counseling patients and families on clinical status and prognosis. The PASS also has potential to advance the implementation of PPA clinical trials. Conclusions PPA patients display heterogeneous language profiles that change over time given the progressive nature of the disease. The monitoring of symptom progression is therefore crucial to ensure that proposed treatments are appropriate at

Assessment of iron status in settings of inflammation: challenges and potential approaches.

Science.gov (United States)

Suchdev, Parminder S; Williams, Anne M; Mei, Zuguo; Flores-Ayala, Rafael; Pasricha, Sant-Rayn; Rogers, Lisa M; Namaste, Sorrel Ml

2017-12-01

The determination of iron status is challenging when concomitant infection and inflammation are present because of confounding effects of the acute-phase response on the interpretation of most iron indicators. This review summarizes the effects of inflammation on indicators of iron status and assesses the impact of a regression analysis to adjust for inflammation on estimates of iron deficiency (ID) in low- and high-infection-burden settings. We overviewed cross-sectional data from 16 surveys for preschool children (PSC) ( n = 29,765) and from 10 surveys for nonpregnant women of reproductive age (WRA) ( n = 25,731) from the Biomarkers Reflecting the Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Effects of C-reactive protein (CRP) and α1-acid glycoprotein (AGP) concentrations on estimates of ID according to serum ferritin (SF) (used generically to include plasma ferritin), soluble transferrin receptor (sTfR), and total body iron (TBI) were summarized in relation to infection burden (in the United States compared with other countries) and population group (PSC compared with WRA). Effects of the concentrations of CRP and AGP on SF, sTfR, and TBI were generally linear, especially in PSC. Overall, regression correction changed the estimated prevalence of ID in PSC by a median of +25 percentage points (pps) when SF concentrations were used, by -15 pps when sTfR concentrations were used, and by +14 pps when TBI was used; the estimated prevalence of ID in WRA changed by a median of +8 pps when SF concentrations were used, by -10 pps when sTfR concentrations were used, and by +3 pps when TBI was used. In the United States, inflammation correction was done only for CRP concentrations because AGP concentrations were not measured; regression correction for CRP concentrations increased the estimated prevalence of ID when SF concentrations were used by 3 pps in PSC and by 7 pps in WRA. The correction of iron-status indicators for inflammation with the

[Current Status and Challenges of CAR-T Immunotherapy in Hematologic Malignancies -Review].

Science.gov (United States)

Cheng, Xin; Wang, Ya-Jie; Feng, Shuai; Wu, Ya-Yun; Yang, Tong-Hua; Lai, Xun

2018-04-01

The chimeric antigen receptor (CAR) T cell therapy has gradually became a new trend in the treatment of refractory and relapsed hematologic malignancies by developing for 30 years. With the exciting development of genetic engineering, CAR-T technology has subjected to 4 generations of innovation. Structure of CAR-T started from a single signal molecule to 2 or more than 2 co-stimulatory molecules, and then coding the CAR gene or promoter. CAR-T can specifically recognize tumor antigens, and does not be restricted by major histocompatibility complex (MHC), thus making a breakthrough in clinical treatment. In this review, the history, structure and mechanism of action of CAR-T, as well as the current status and challenges of CAR-T immunotherapy in acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia and multiple myeloma are summarized.

Corpus callosum atrophy as a marker of clinically meaningful cognitive decline in secondary progressive multiple sclerosis. Impact on employment status.

Science.gov (United States)

Papathanasiou, Athanasios; Messinis, Lambros; Zampakis, Petros; Papathanasopoulos, Panagiotis

2017-09-01

Cognitive impairment in Multiple Sclerosis (MS) is more frequent and pronounced in secondary progressive MS (SPMS). Cognitive decline is an important predictor of employment status in patients with MS. Magnetic Resonance Imaging (MRI) markers have been used to associate tissue damage with cognitive dysfunction. The aim of the study was to designate the MRI marker that predicts cognitive decline in SPMS and explore its effect on employment status. 30 SPMS patients and 30 healthy participants underwent neuropsychological assessment using the Trail Making Test (TMT) parts A and B, semantic and phonological verbal fluency task and a computerized cognitive screening battery (Central Nervous System Vital Signs). Employment status was obtained as a quality of life measure. Brain MRI was performed in all participants. We measured total lesion volume, third ventricle width, thalamic and corpus callosum atrophy. The frequency of cognitive decline for our SPMS patients was 80%. SPMS patients differed significantly from controls in all neuropsychological measures. Corpus callosum area was correlated with cognitive flexibility, processing speed, composite memory, executive functions, psychomotor speed, reaction time and phonological verbal fluency task. Processing speed and composite memory were the most sensitive markers for predicting employment status. Corpus callosum area was the most sensitive MRI marker for memory and processing speed. Corpus callosum atrophy predicts a clinically meaningful cognitive decline, affecting employment status in our SPMS patients. Copyright © 2017 Elsevier Ltd. All rights reserved.

22 CFR 9.8 - Classification challenges.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Classification challenges. 9.8 Section 9.8 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.8 Classification... classification status is improper are expected and encouraged to challenge the classification status of the...

The Glass Ceiling: Progress and Persistent Challenges

Science.gov (United States)

McLlwain, Wendy M.

2012-01-01

It has been written that since 2001, there has not been any significant progress and the glass ceiling is still intact. Women are still underrepresented in top positions (Anonymous, 2004). If this is true, the glass ceiling presents a major barrier between women and their desire to advance into executive or senior management positions. In addition…

Tobacco Control Policies in Vietnam: Review on MPOWER Implementation Progress and Challenges.

Science.gov (United States)

Minh, Hoang Van; Ngan, Tran Thu; Mai, Vu Quynh; My, Nguyen Thi Tuyet; Chung, Le Hong; Kien, Vu Duy; Anh, Tran Tuan; Ngoc, Nguyen Bao; Giap, Vu Van; Cuong, Nguyen Manh; Manh, Pham Duc; Giang, Kim Bao

2016-01-01

In Vietnam, the WHO Framework Convention on Tobacco Control (WHO FCTC) took effect in March 2005 while MPOWER has been implemented since 2008. This paper describes the progress and challenges of implementation of the MPOWER package in Vietnam. We can report that, in term of monitoring, Vietnam is very active in the Global Tobacco Surveillance System, completing two rounds of the Global Adult Tobacco Survey (GATS) and three rounds of the Global Youth Tobacco Survey (GYTS). To protect people from tobacco smoke, Vietnam has issued and enforced a law requiring comprehensive smoking bans at workplaces and public places since 2013. Tobacco advertising and promotion are also prohibited with the exception of points of sale displays of tobacco products. Violations come in the form of promotion girls, corporate social responsibility activities from tobacco manufacturers and packages displayed by retail vendors. Vietnam is one of the 77 countries that require pictorial health warnings to be printed on cigarette packages to warn about the danger of tobacco and the warnings have been implemented effectively. Cigarette tax is 70% of factory price which is equal to less than 45% of retail price and much lower than the recommendation of WHO. However, Vietnam is one of the very few countries that require manufacturers and importers to make "compulsory contributions" at 1-2% of the factory price of cigarettes sold in Vietnam for the establishment of a Tobacco Control Fund (TCF). The TCF is being operated well. In 2015, 67 units of 63 provinces/cities, 22 ministries and political-social organizations and 6 hospitals received funding from TCF to implement a wide range of tobacco control activities. Cessation services have been starting with a a toll-free quit-line but need to be further strengthened. In conclusion, Vietnam has constantly put efforts into the tobacco control field with high commitment from the government, scientists and activists. Though several remarkable achievements

SuperB Progress Report: Detector

Energy Technology Data Exchange (ETDEWEB)

Grauges, E.; /Barcelona U., ECM; Donvito, G.; Spinoso, V.; /INFN, Bari /Bari U.; Manghisoni, M.; Re, V.; Traversi, G.; /INFN, Pavia /Bergamo U., Ingengneria Dept.; Eigen, G.; Fehlker, D.; Helleve, L.; /Bergen U.; Carbone, A.; Di Sipio, R.; Gabrielli, A.; Galli, D.; Giorgi, F.; Marconi, U.; Perazzini, S.; Sbarra, C.; Vagnoni, V.; Valentinetti, S.; Villa, M.; Zoccoli, A.; /INFN, Bologna /Bologna U. /Caltech /Carleton U. /Cincinnati U. /INFN, CNAF /INFN, Ferrara /Ferrara U. /UC, Irvine /Taras Shevchenko U. /Orsay, LAL /LBL, Berkeley /UC, Berkeley /Frascati /INFN, Legnaro /Orsay, IPN /Maryland U. /McGill U. /INFN, Milan /Milan U. /INFN, Naples /Naples U. /Novosibirsk, IYF /INFN, Padua /Padua U. /INFN, Pavia /Pavia U. /INFN, Perugia /Perugia U. /INFN, Perugia /Caltech /INFN, Pisa /Pisa U. /Pisa, Scuola Normale Superiore /PNL, Richland /Queen Mary, U. of London /Rutherford /INFN, Rome /Rome U. /INFN, Rome2 /Rome U.,Tor Vergata /INFN, Rome3 /Rome III U. /SLAC /Tel Aviv U. /INFN, Turin /Turin U. /INFN, Padua /Trento U. /INFN, Trieste /Trieste U. /TRIUMF /British Columbia U. /Montreal U. /Victoria U.

2012-02-14

This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

SuperB Progress Report: Detector

International Nuclear Information System (INIS)

Grauges, E.; Donvito, G.; Spinoso, V.; Manghisoni, M.; Re, V.; Traversi, G.; Eigen, G.; Fehlker, D.; Helleve, L.; Cheng, C.; Chivukula, A.; Doll, D.; Echenard, B.; Hitlin, D.; Ongmongkolkul, P.; Porter, F.; Rakitin, A.; Thomas, M.; Zhu, R.; Tatishvili, G.; Andreassen, R.; Fabby, C.; Meadows, B.; Simpson, A.; Sokoloff, M.; Tomko, K.; Fella, A.; Andreotti, M.; Baldini, W.; Calabrese, R.; Carassiti, V.; Cibinetto, G.; Cotta Ramusino, A.; Gianoli, A.; Luppi, E.; Munerato, M.; Santoro, V.; Tomassetti, L.; Stoker, D.; Bezshyyko, O.; Dolinska, G.; Arnaud, N.; Beigbeder, C.; Bogard, F.; Breton, D.; Burmistrov, L.; Charlet, D.; Maalmi, J.; Perez Perez, L.; Puill, V.; Stocchi, A.; Tocut, V.; Wallon, S.; Wormser, G.; Brown, D.

2012-01-01

This report describes the present status of the detector design for SuperB. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

SuperB Progress Reports Accelerator

CERN Document Server

Biagini, Maria Enrica; Boscolo, M; Buonomo, B; Demma, T; Drago, A; Esposito, M; Guiducci, S; Mazzitelli, G; Pellegrino, L; Preger, M A; Raimondi, P; Ricci, R; Rotundo, U; Sanelli, C; Serio, M; Stella, A; Tomassini, S; Zobov, M; Bertsche, K; Brachman, A; Cai, Y; Chao, A; Chesnut, R; Donald, M.H; Field, C; Fisher, A; Kharakh, D; Krasnykh, A; Moffeit, K; Nosochkov, Y; Pivi, M; Seeman, J; Sullivan, M.K; Weathersby, S; Weidemann, A; Weisend, J; Wienands, U; Wittmer, W; Woods, M; Yocky, G; Bogomiagkov, A; Koop, I; Levichev, E; Nikitin, S; Okunev, I; Piminov, P; Sinyatkin, S; Shatilov, D; Vobly, P; Bosi, F; Liuzzo, S; Paoloni, E; Bonis, J; Chehab, R; Le Meur, G; Lepercq, P; Letellier-Cohen, F; Mercier, B; Poirier, F; Prevost, C; Rimbault, C; Touze, F; Variola, A; Bolzon, B; Brunetti, L; Jeremie, A; Baylac, M; Bourrion, O; De Conto, J M; Gomez, Y; Meot, F; Monseu, N; Tourres, D; Vescovi, C; Chanci, A; Napoly, O; Barber, D P; Bettoni, S; Quatraro, D

2010-01-01

This report details the present status of the Accelerator design for the SuperB Project. It is one of four separate progress reports that, taken collectively, describe progress made on the SuperB Project since the publication of the SuperB Conceptual Design Report in 2007 and the Proceedings of SuperB Workshop VI in Valencia in 2008.

Model Agreements for the granting of Associate Member Status Implementation arrangements concerning eligibility for personnel appointments and industrial participation for Associate Member States Progress report by the Management

CERN Document Server

2011-01-01

Model Agreements for the granting of Associate Member Status Implementation arrangements concerning eligibility for personnel appointments and industrial participation for Associate Member States Progress report by the Management

Fuel Cell Buses in U.S. Transit Fleets: Current Status 2015

Energy Technology Data Exchange (ETDEWEB)

Eudy, Leslie [National Renewable Energy Lab. (NREL), Golden, CO (United States); Post, Matthew [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gikakis, Christina [Federal Transit Administration, Washington, DC (United States)

2015-12-11

This report, published annually, summarizes the progress of fuel cell electric bus (FCEB) development in the United States and discusses the achievements and challenges of introducing fuel cell propulsion in transit. Various stakeholders, including FCEB developers, transit agencies, and system integrators, have expressed the value of this annual status report, which provides a summary of results from evaluations performed by the National Renewable Energy Laboratory. The annual status report tracks the progress of the FCEB industry toward meeting technical targets, documents the lessons learned, and discusses the path forward for commercial viability of fuel cell technology for transit buses. The 2015 summary results primarily focus on the most recent year for each demonstration, from August 2014 through July 2015. The results for these buses account for more than 1,045,000 miles traveled and 83,000 hours of fuel cell power system operation. The primary results presented in the report are from two demonstrations of fuel-cell-dominant bus designs: the Zero Emission Bay Area Demonstration Group led by Alameda-Contra Costa Transit District (AC Transit) in California and the American Fuel Cell Bus Project at SunLine Transit Agency in California.

Phytoextraction of Cd-Contaminated Soils: Current Status and Future Challenges.

Science.gov (United States)

Li, Jin-Tian; Baker, Alan J M; Ye, Zhi-Hong; Wang, Hong-Bin; Shu, Wen-Sheng

2012-10-01

Cadmium (Cd) is one of the most toxic and widely distributed pollutants in the environment. Cadmium contamination of soils has posed a serious threat to safe food production in many parts of the world. The authors present a comprehensive review of present status of phytoextraction technology for cleaning up Cd-contaminated soils, based primarily on the data resulting from both laboratory and field-scale studies that have been conducted to assess or improve the Cd phytoextraction potential of various plant species in the past decade. The encouraging results of field-scale studies have provided a fundamental basis to usher phytoextraction technology into practical use to remediate slightly to moderately Cd-contaminated soils in Europe and Asia, although this technology is not yet ready for widespread application. Chelators and microorganisms tested so far seem not to contribute to the applicability of Cd phytoextraction. The major challenges for the large-scale application of Cd phytoextraction are (a) how to further improve the efficiency of Cd phytoextraction, (b) how to cut the overall costs of Cd phytoextraction, and (c) how to get greater stakeholders' acceptance of Cd phytoextraction as a reliable option.

Opportunities and Challenges in Deep Mining: A Brief Review

Directory of Open Access Journals (Sweden)

Pathegama G. Ranjith

2017-08-01

Full Text Available Mineral consumption is increasing rapidly as more consumers enter the market for minerals and as the global standard of living increases. As a result, underground mining continues to progress to deeper levels in order to tackle the mineral supply crisis in the 21st century. However, deep mining occurs in a very technical and challenging environment, in which significant innovative solutions and best practice are required and additional safety standards must be implemented in order to overcome the challenges and reap huge economic gains. These challenges include the catastrophic events that are often met in deep mining engineering: rockbursts, gas outbursts, high in situ and redistributed stresses, large deformation, squeezing and creeping rocks, and high temperature. This review paper presents the current global status of deep mining and highlights some of the newest technological achievements and opportunities associated with rock mechanics and geotechnical engineering in deep mining. Of the various technical achievements, unmanned working-faces and unmanned mines based on fully automated mining and mineral extraction processes have become important fields in the 21st century.

Progress and controversies in developing cancer vaccines

Directory of Open Access Journals (Sweden)

Speiser Daniel E

2005-04-01

Full Text Available Abstract Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2 and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, and there has been substantial progress in identifying shared antigens recognized by T cells, in developing vaccine approaches that induce antigen-specific T cell responses in cancer patients, and in developing new technology for monitoring immune responses in various human tissue compartments. Dramatic clinical regressions of human solid tumors have occurred with some cancer vaccines, but the rate of those responses remains low. This article is part of a 2-part point:counterpoint series on peptide vaccines and adoptive therapy approaches for cancer. The current status of cancer vaccination, and associated challenges, are discussed. Emphasis is placed on the need to increase our knowledge of cancer immunobiology, as well as to improve monitoring of cellular immune function after vaccination. Progress in both areas will facilitate development of effective cancer vaccines, as well as of adoptive therapy. Effective cancer vaccines promise to be useful for treatment and prevention of cancer at low cost and with low morbidity.

Progress and challenges in cleaning up Hanford

Energy Technology Data Exchange (ETDEWEB)

Wagoner, J.D. [Dept. of Energy, Richland, WA (United States)

1997-08-01

This paper presents captioned viewgraphs which briefly summarize cleanup efforts at the Hanford Site. Underground waste tank and spent nuclear fuel issues are described. Progress is reported for the Plutonium Finishing Plant, PUREX plant, B-Plant/Waste Encapsulation Storage Facility, and Fast Flux Test Facility. A very brief overview of costs and number of sites remediated and/or decommissioned is given.

Detection and quantification of proteins and cells by use of elemental mass spectrometry: progress and challenges.

Science.gov (United States)

Yan, Xiaowen; Yang, Limin; Wang, Qiuquan

2013-07-01

Much progress has been made in identification of the proteins in proteomes, and quantification of these proteins has attracted much interest. In addition to popular tandem mass spectrometric methods based on soft ionization, inductively coupled plasma mass spectrometry (ICPMS), a typical example of mass spectrometry based on hard ionization, usually used for analysis of elements, has unique advantages in absolute quantification of proteins by determination of an element with a definite stoichiometry in a protein or attached to the protein. In this Trends article, we briefly describe state-of-the-art ICPMS-based methods for quantification of proteins, emphasizing protein-labeling and element-tagging strategies developed on the basis of chemically selective reactions and/or biospecific interactions. Recent progress from protein to cell quantification by use of ICPMS is also discussed, and the possibilities and challenges of ICPMS-based protein quantification for universal, selective, or targeted quantification of proteins and cells in a biological sample are also discussed critically. We believe ICPMS-based protein quantification will become ever more important in targeted quantitative proteomics and bioanalysis in the near future.

Nuclear challenges and progress in designing stellarator fusion power plants

International Nuclear Information System (INIS)

El-Guebaly, L.A.; Wilson, P.; Henderson, D.; Sawan, M.; Sviatoslavsky, G.; Tautges, T.; Slaybaugh, R.; Kiedrowski, B.; Ibrahim, A.

2008-01-01

Over the past 5-6 decades, stellarator power plants have been studied in the US, Europe, and Japan as an alternate to the mainline magnetic fusion tokamaks, offering steady-state operation and eliminating the risk of plasma disruptions. The earlier 1980s studies suggested large-scale stellarator power plants with an average major radius exceeding 20 m. The most recent development of the compact stellarator concept delivered ARIES-CS - a compact stellarator with 7.75 m average major radius, approaching that of tokamaks. For stellarators, the most important engineering parameter that determines the machine size and cost is the minimum distance between the plasma boundary and mid-coil. Accommodating the breeding blanket and necessary shield within this distance to protect the ARIES-CS superconducting magnet represents a challenging task. Selecting the ARIES-CS nuclear and engineering parameters to produce an economic optimum, modeling the complex geometry for 3D nuclear analysis to confirm the key parameters, and minimizing the radwaste stream received considerable attention during the design process. These engineering design elements combined with advanced physics helped enable the compact stellarator to be a viable concept. This paper provides a brief historical overview of the progress in designing stellarator power plants and a perspective on the successful integration of the nuclear activity into the final ARIES-CS configuration

700 C power plant technology. Status and challenge

Energy Technology Data Exchange (ETDEWEB)

Tschaffon, Helmut [E.ON Energie AG, Muenchen (Germany)

2010-07-01

Coal will remain an indispensable major source of energy for power generation in the world in the coming decades, because there are resources for hundreds of years. Coal fired power plants can be operated very flexible which gets increasing importance due to the stochastic input from regenerative energies like wind and solar energy. Sustainable technologies for cool-fired power plants have to be developed to optimise environmental protection and to save valuable resources and reduce CO{sub 2}-emissions. Future coal fired steam power plants aim an elevated steam temperature of about 700 C to reach a net efficiency of about 50%. This paper will give an overview over the status of the development of the 700 C technology and will highlight the challenges to be overcome before their commercial use. The European way to a 700 C Power plant started with the project AD700 in the year 1998. In this project the basic design of a 400 MW demo plant was done and some material tests and component qualifications for nickel-based alloys and new austenitic steels were started and terminated. AD700 delivered the basis of the design of the Component Test Facility COMTES700 (RFCS funded project with European manufacturers and utilities). COMTES 700 was operated between 2005 and 2009. It was integrated into the E.ON power plant Scholven in Germany to test mainly nickel based materials and power plant components. In the project NRWPP700 (2006-2010, funded by NRW and financed by European utilities) the detail design of the steam generator, piping system and turbine of a 500 MW power plant was done. In 7 material projects the qualification of components and materials was supported. At the same time of lot of national and international R and D projects (e.g. MARCKO and COORETEC) were performed. Due to the high amount of these projects they cannot be mentioned here in a detailed way. In 2007 the E.ON project 50plus was started. The aim was to plan and build a 700 C demo plant in

Status and progress of the RERTR program

International Nuclear Information System (INIS)

Travelli, A.

1996-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. The major events, findings, and activities of 1996 are reviewed after a brief summary of the results which the RERTR Program had achieved by the end of 1995 in collaboration with its many international partners. Significant progress has been made during the past year in each of the three areas that the delegates to last year's RERTR meeting chose to address, in their letter to President Clinton, as requiring special attention. (1) In the area of U.S. acceptance of spent fuel from foreign research reactors, a second shipment of 99 urgent-relief spent fuel elements was completed. The Final Environmental Impact Statement was published in February 1996, and the Record of Decision was published in May 1996. The first shipments under the Record of Decision, containing 280 spent fuel elements, were received at the Savannah River Site in September 1996. (2) In the area of advanced fuel development, adequate funding and guidance were received by the RERTR program in March 1996. Fuel development activities are now in progress, including procurement of equipment, screening of candidate materials, and preparations for the production of a first series of microplates. The first irradiations are planned to begin in the Advanced Test Reactor. in Idaho, during April 1997. (3) In the area of conversion of DOE research reactors, the RERTR program has been tasked by the Department of Energy to assess the feasibility of converting to LEU fuel each of the DOE research reactors which currently use HEU fuel. A preliminary assessment will be presented at this meeting. Significant progress has been made by the Russian RERTR program, which aims to develop and demonstrate within the next five years the technical means needed to convert Russian-supplied research reactors to LEU fuels. The study of an alternative LEU core for the FRM-II design has been extended to address, with excellent results

Nondiabetic Glucometabolic Status and Progression of Aortic Stiffness

DEFF Research Database (Denmark)

McEniery, Carmel M; Wilkinson, Ian B; Johansen, Nanna B

2017-01-01

-up. At baseline, cfPWV was associated with fasting and 2-h postload glucose, HbA1c, and HOMA-insulin resistance (HOMA-IR). HbA1c and HOMA-IR were associated with progression of cfPWV after adjusting for physiological confounders and cardiovascular risk factors. A 1 SD higher HbA1c and HOMA-IR were associated...... with greater increases in cfPWV (0.11 m/s per 5 years [95% CI 0.04, 0.18], P = 0.003 and 0.09 m/s per 5 years [0.01, 0.17], P = 0.03, respectively). Additional adjustment for BMI weakened the association with HOMA-IR but not with HbA1c. CONCLUSIONS HbA1c is independently associated with accelerated progression...

Host transcriptional responses following ex vivo re-challenge with Mycobacterium tuberculosis vary with disease status.

Directory of Open Access Journals (Sweden)

Elaine A Yu

Full Text Available The identification of immune correlates that are predictive of disease outcome for tuberculosis remains an ongoing challenge. To address this issue, we evaluated gene expression profiles from peripheral blood mononuclear cells following ex vivo challenge with Mycobacterium tuberculosis, among participants with active TB disease (ATBD, n = 10, latent TB infection (LTBI, n = 10, and previous active TB disease (after successful treatment; PTBD, n = 10, relative to controls (n = 10. Differential gene expression profiles were assessed by suppression-subtractive hybridization, dot blot, real-time polymerase chain reaction, and the comparative cycle threshold methods. Comparing ATBD to control samples, greater fold-increases of gene expression were observed for a number of chemotactic factors (CXCL1, CXCL3, IL8, MCP1, MIP1α. ATBD was also associated with higher IL1B gene expression, relative to controls. Among LTBI samples, gene expression of several chemotactic factors (CXCL2, CXCL3, IL8 was similarly elevated, compared to individuals with PTBD. Our results demonstrated that samples from participants with ATBD and LTBI have distinct gene expression profiles in response to ex vivo M. tuberculosis infection. These findings indicate the value in further characterizing the peripheral responses to M. tuberculosis challenge as a route to defining immune correlates of disease status or outcome.

Host transcriptional responses following ex vivo re-challenge with Mycobacterium tuberculosis vary with disease status.

Science.gov (United States)

Yu, Elaine A; John, Serene H; Tablante, Elizabeth C; King, Christine A; Kenneth, John; Russell, David G; Mehta, Saurabh

2017-01-01

The identification of immune correlates that are predictive of disease outcome for tuberculosis remains an ongoing challenge. To address this issue, we evaluated gene expression profiles from peripheral blood mononuclear cells following ex vivo challenge with Mycobacterium tuberculosis, among participants with active TB disease (ATBD, n = 10), latent TB infection (LTBI, n = 10), and previous active TB disease (after successful treatment; PTBD, n = 10), relative to controls (n = 10). Differential gene expression profiles were assessed by suppression-subtractive hybridization, dot blot, real-time polymerase chain reaction, and the comparative cycle threshold methods. Comparing ATBD to control samples, greater fold-increases of gene expression were observed for a number of chemotactic factors (CXCL1, CXCL3, IL8, MCP1, MIP1α). ATBD was also associated with higher IL1B gene expression, relative to controls. Among LTBI samples, gene expression of several chemotactic factors (CXCL2, CXCL3, IL8) was similarly elevated, compared to individuals with PTBD. Our results demonstrated that samples from participants with ATBD and LTBI have distinct gene expression profiles in response to ex vivo M. tuberculosis infection. These findings indicate the value in further characterizing the peripheral responses to M. tuberculosis challenge as a route to defining immune correlates of disease status or outcome.

The RERTR program status and progress

International Nuclear Information System (INIS)

Travelli, A.

2004-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. The major events, findings, and activities of 1995 are reviewed after a brief summary of the results which the RERTR Program had achieved by the end of 994 in collaboration with its many international partners. The revelation that Iraq was on the verge of developing a nuclear weapon at the time of the Gulf War, and that it was planning to do so by extracting HEU from the fuel of its research reactors, has given new impetus and urgency to the RERTR commitment of eliminating HEU use in research and test reactors worldwide. The Draft Environmental Impact Statement on the DOE policy for managing spent nuclear fuels from foreign research reactors was published on schedule. A Record of Decision is due in December 1995. After much legal debate, a first shipment of 153 urgent-relief elements took place, and another 151 elements became eligible for shipment. Development of advanced LEU research reactor fuels is scheduled to begin in October 1995, after DOE funding is received. Funding for equipment needed to begin this activity was provided by the US Department of State, and procurement of the equipment is in progress. The Russian RERTR program, which aims to develop and demonstrate within the next five years the technical means needed to convert Russian-supplied research reactors to LEU fuels, is now in operation. A Statement of Intent was signed by high US and Chinese officials, endorsing cooperative activities between the RERTR program and Chinese laboratories involved in similar activities. Joint studies of LEU technical feasibility were completed for the SAFARI-1 reactor in South Africa and for the ANS reactor in the US. The ANS project was later canceled for budgetary and nonproliferation reasons. A new study has been initiated for the FRM-II reactor in Germany. Significant progress was made on several aspects of producing 99 Mo from fission targets utilizing LEU instead of

Progress and challenges of the ITER TBM Program from the IO perspective

Energy Technology Data Exchange (ETDEWEB)

Giancarli, L.M., E-mail: luciano.giancarli@iter.org [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance (France); Barabash, V.; Campbell, D.J.; Chiocchio, S.; Cordier, J.-J.; Dammann, A.; Dell’Orco, G.; Elbez-Uzan, J.; Fourneron, J.M.; Friconneau, J.P. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance (France); Gasparotto, M. [Max-Planck-Institut für Plasmaphysik, Wendelsteinstraße 1, 17491 Greifswald (Germany); Iseli, M.; Jung, C.-Y.; Kim, B.-Y.; Lazarov, D.; Levesy, B.; Loughlin, M.; Merola, M. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance (France); Nevière, J.-C. [Comex-Nucleaire, 13115 Saint Paul Lez Durance (France); Pascal, R. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance (France); and others

2016-11-01

The paper describes the organization of the Test Blanket Module (TBM) program, its overall objective and schedule and the status of the technical activities within the ITER Organization-Central Team (IO-CT). The latter include the design integration of the Test Blanket Systems (TBSs) into the nuclear buildings, ensuring all interfaces with other ITER systems, the design of the common TBS components such as the TBM Frames, the Dummy TBMs, and the TBS maintenance tools and equipment in the TBM Port Cell as well as in the Hot Cell building, the design of the TBS connection pipes and the definition of the required maintenance operations and associated R&D. The paper also discusses the major challenges that the TBM Program will be facing in ITER such as the potential impact of the TBMs ferritic/martensitic structures on plasma operations, the approaches to tritium and contamination confinement, the required mitigation and recovery actions in case of accidents, and the assessment of the reliability aspects that could have an impact on ITER availability.

Progress and challenges of the ITER TBM Program from the IO perspective

International Nuclear Information System (INIS)

Giancarli, L.M.; Barabash, V.; Campbell, D.J.; Chiocchio, S.; Cordier, J.-J.; Dammann, A.; Dell’Orco, G.; Elbez-Uzan, J.; Fourneron, J.M.; Friconneau, J.P.; Gasparotto, M.; Iseli, M.; Jung, C.-Y.; Kim, B.-Y.; Lazarov, D.; Levesy, B.; Loughlin, M.; Merola, M.; Nevière, J.-C.; Pascal, R.

2016-01-01

The paper describes the organization of the Test Blanket Module (TBM) program, its overall objective and schedule and the status of the technical activities within the ITER Organization-Central Team (IO-CT). The latter include the design integration of the Test Blanket Systems (TBSs) into the nuclear buildings, ensuring all interfaces with other ITER systems, the design of the common TBS components such as the TBM Frames, the Dummy TBMs, and the TBS maintenance tools and equipment in the TBM Port Cell as well as in the Hot Cell building, the design of the TBS connection pipes and the definition of the required maintenance operations and associated R&D. The paper also discusses the major challenges that the TBM Program will be facing in ITER such as the potential impact of the TBMs ferritic/martensitic structures on plasma operations, the approaches to tritium and contamination confinement, the required mitigation and recovery actions in case of accidents, and the assessment of the reliability aspects that could have an impact on ITER availability.

Fuel Cell Buses in U.S. Transit Fleets: Current Status 2011

Energy Technology Data Exchange (ETDEWEB)

Eudy, L.; Chandler, K.; Gikakis, C.

2011-11-01

This status report, fifth in a series of annual status reports from the U.S. Department of Energy's National Renewable Energy Laboratory (NREL), discusses the achievements and challenges of fuel cell propulsion for transit and summarizes the introduction of fuel cell transit buses in the United States. Progress this year includes an increase in the number of fuel cell electric buses (FCEBs), from 15 to 25, operating at eight transit agencies, as well as increased diversity of the fuel cell design options for transit buses. The report also provides an analysis of the combined results from fuel cell transit bus demonstrations evaluated by NREL with a focus on the most recent data through July 2011 including fuel cell power system reliability and durability; fuel economy; roadcall; and hydrogen fueling results. These evaluations cover 22 of the 25 FCEBs currently operating.

Advanced materials for sodium-beta alumina batteries: Status, challenges and perspectives

Science.gov (United States)

Lu, Xiaochuan; Xia, Guanguang; Lemmon, John P.; Yang, Zhenguo

The increasing penetration of renewable energy and the trend toward clean, efficient transportation have spurred growing interests in sodium-beta alumina batteries that store electrical energy via sodium ion transport across a β″-Al 2O 3 solid electrolyte at elevated temperatures (typically 300-350 °C). Currently, the negative electrode or anode is metallic sodium in molten state during battery operation; the positive electrode or cathode can be molten sulfur (Na-S battery) or solid transition metal halides plus a liquid phase secondary electrolyte (e.g., ZEBRA battery). Since the groundbreaking works in the sodium-beta alumina batteries a few decades ago, encouraging progress has been achieved in improving battery performance, along with cost reduction. However, there remain issues that hinder broad applications and market penetration of the technologies. To better the Na-beta alumina technologies require further advancement in materials along with component and system design and engineering. This paper offers a comprehensive review on materials of electrodes and electrolytes for the Na-beta alumina batteries and discusses the challenges ahead for further technology improvement.

Advanced materials for sodium-beta alumina batteries: Status, challenges and perspectives

International Nuclear Information System (INIS)

Lu, Xiaochuan; Xia, Guanguang; Lemmon, John P.; Yang, Zhenguo

2010-01-01

The increasing penetration of renewable energy and the trend toward clean, efficient transportation have spurred growing interests in sodium-beta alumina batteries that store electrical energy via sodium ion transport across a β''-Al 2 O 3 solid electrolyte at elevated temperatures (typically 300-350 C). Currently, the negative electrode or anode is metallic sodium in molten state during battery operation; the positive electrode or cathode can be molten sulfur (Na-S battery) or solid transition metal halides plus a liquid phase secondary electrolyte (e.g., ZEBRA battery). Since the groundbreaking works in the sodium-beta alumina batteries a few decades ago, encouraging progress has been achieved in improving battery performance, along with cost reduction. However, there remain issues that hinder broad applications and market penetration of the technologies. To better the Na-beta alumina technologies require further advancement in materials along with component and system design and engineering. This paper offers a comprehensive review on materials of electrodes and electrolytes for the Na-beta alumina batteries and discusses the challenges ahead for further technology improvement. (author)

Quantifying progress toward a conservation assessment for all plants.

Science.gov (United States)

Bachman, Steven P; Nic Lughadha, Eimear M; Rivers, Malin C

2018-06-01

The Global Strategy for Plant Conservation (GSPC) set an ambitious target to achieve a conservation assessment for all known plant species by 2020. We consolidated digitally available plant conservation assessments and reconciled their scientific names and assessment status to predefined standards to provide a quantitative measure of progress toward this target. The 241,919 plant conservation assessments generated represent 111,824 accepted land plant species (vascular plants and bryophytes, not algae). At least 73,081 and up to 90,321 species have been assessed at the global scale, representing 21-26% of known plant species. Of these plant species, at least 27,148 and up to 32,542 are threatened. Eighty plant families, including some of the largest, such as Asteraceae, Orchidaceae, and Rubiaceae, are underassessed and should be the focus of assessment effort if the GSPC target is to be met by 2020. Our data set is accessible online (ThreatSearch) and is a baseline that can be used to directly support other GSPC targets and plant conservation action. Although around one-quarter of a million plant assessments have been compiled, the majority of plants are still unassessed. The challenge now is to build on this progress and redouble efforts to document conservation status of unassessed plants to better inform conservation decisions and conserve the most threatened species. © 2017 The Authors. Conservation Biology published by Wiley Periodicals, Inc. on behalf of Society for Conservation Biology.

Media Challenging Status Quo

DEFF Research Database (Denmark)

Sandvik, Kjetil

and Libya creating headlines like “the Facebook revolution”. On the other hand, several scholars argue that it is naive to believe that social media in themselves create change: they may at the best facilitate already existing social and political movements (Downing 2008, Christakis & Fowler 2010...... and communication research is currently engaging in a longer and deeper process of examining and assessing the cultural consequences of networked communication. One present challenge is to understand digital media and networked communication at the intersection of established and countercultural, utopian......Digital media and especially so-called ‘social media’ have on the one hand been ascribed the power to change societies and empower democratic movements following the thoughts of e.g. Rheingold (2004), recently fueled by the democratic uprising in Arabic countries such as Egypt, Tunisia, Iran...

Factors of progress in reading literacy test

Directory of Open Access Journals (Sweden)

Jovanović Vitomir

2011-01-01

Full Text Available The main goal of this study was to identify the factors which are most associated with the progress in reading literacy assessed in the PISA survey. In the preliminary sample, students from ten schools (N=235 were retested two years after the 2009 PISA original study. There were measured intrinsic and extrinsic motivation, school self-efficacy, epistemological beliefs, metacognitive strategies, socio-economic status, enjoyment and preference for reading and motivation and self-regulation. The examined factors explain 27% of the variance in reading literacy progress. Factors that contribute most to this progress are school self-efficacy, proper use of metacognitive strategies and low extrinsic motivation. Socio-economic status explained a negligible amount of variance, while some effect of type of school on progress in reading literacy (η2=7% was observed. Achievement in reading literacy is correlated with school marks. Students who attend secondary schools are more likely to make progress in reading literacy than those who attend vocational schools. An attempt was made to formulate the implications for education policy based on this research.

Attitudes towards digital gap among university students, and its relationship with educational progress and socioeconomic status

Directory of Open Access Journals (Sweden)

Z Derikvandi

2017-03-01

Full Text Available Introduction: Digital gap may exist in national scale, among organizations and other groups of society, since it is an indicative of inequality in information technology ground and communication. This study aims to investigate the attitude towards digital gap among students, and its relationship with educational progress and socio-economic  status (SES of university students at Alborz University of Medical Sciences. Methods: This was a cross sectional analytic study. students were randomly selected according to multistage cluster method. The tools for collecting data were Davis (1989 questionnaire on attitude towards internet, and  a researcher made questionnaire. The formal validity of the questionnaires is confirmed by a panel of experts, Cronbach's alpha's coefficient was also calculated. Pearson coefficient were calculated andindependent T- test was used for analyzing the data. Result: The analysis of data indicates that there is a meaningful relationship between the attitude towards digital gap and educational progress, and also SES of the students. Furthermore, there was adifferences between the attitudes of males (48.7 and felames (46.5 toward digital gap (p=0.01. Conclusion:There is an attitude towards digital gap in university students. Interventions are needed to close the digital gaps in studnets.

Status inequalities, perceived discrimination, and eudaimonic well-being: do the challenges of minority life hone purpose and growth?

Science.gov (United States)

Ryff, Carol D; Keyes, Corey L; Hughes, Diane L

2003-09-01

Considerable prior research has investigated links between racial/ethnic status and diverse aspects of mental functioning (e.g. psychological disorders, quality of life, self-esteem), but little work has probed the connections between minority status and eudaimonic well-being. Derived from existential and humanistic perspectives, eudaimonia describes engagement in life challenges and is operationalized with assessments of purpose in life, personal growth, autonomy, environmental mastery, self-acceptance, and positive relations with others. Using Midlife in the United States (MIDUS), a national survey of Americans aged 25-74, plus city-specific samples of African Americans in New York City and Mexican Americans in Chicago, minority status was found to be a positive predictor of eudaimonic well-being, underscoring themes of psychological strength in the face of race-related adversity. Perceived discrimination was found to be a negative predictor of eudaimonic well-being, although such effects were gender-specific: it was women, both majority and minority, with high levels of discrimination in their daily lives whose sense of growth, mastery, autonomy, and self-acceptance was compromised.

QCD and strongly coupled gauge theories: challenges and perspectives

CERN Document Server

Brambilla, N.; Foka, P.; Gardner, S.; Kronfeld, A.S.; Alford, M.G.; Alkofer, R.; Butenschoen, M.; Cohen, T.D.; Erdmenger, J.; Fabbietti, L.; Faber, M.; Goity, J.L.; Ketzer, B.; Lin, H.W.; Llanes-Estrada, F.J.; Meyer, H.B.; Pakhlov, P.; Pallante, E.; Polikarpov, M.I.; Sazdjian, H.; Schmitt, A.; Snow, W.M.; Vairo, A.; Vogt, R.; Vuorinen, A.; Wittig, H.; Arnold, P.; Christakoglou, P.; Di Nezza, P.; Fodor, Z.; Garcia i Tormo, X.; Hollwieser, R.; Janik, M.A.; Kalweit, A.; Keane, D.; Kiritsis, E.; Mischke, A.; Mizuk, R.; Odyniec, G.; Papadodimas, K.; Pich, A.; Pittau, R.; Qiu, J.W.; Ricciardi, G.; Salgado, C.A.; Schwenzer, K.; Stefanis, N.G.; von Hippel, G.M.; Zakharov, V.I.

2014-10-21

We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly-coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.

Radiogenomics - current status, challenges and future directions

DEFF Research Database (Denmark)

Andreassen, Christian Nicolaj; Schack, Line Meinertz Hybel; Laursen, Louise Vagner

2016-01-01

years, substantial progress has been achieved in this field. Several compelling associations for SNPs have been demonstrated in large candidate gene studies as well as genome wide association studies. These findings shed new light on radiobiology and expand our understanding of the processes that lead...

Preimplantation genetic diagnosis and screening: Current status and future challenges

Directory of Open Access Journals (Sweden)

Hsin-Fu Chen

2018-02-01

Full Text Available Preimplantation genetic diagnosis (PGD is a clinically feasible technology to prevent the transmission of monogenic inherited disorders in families afflicted the diseases to the future offsprings. The major technical hurdle is it does not have a general formula for all mutations, thus different gene locus needs individualized, customized design to make the diagnosis accurate enough to be applied on PGD, in which the quantity of DNA is scarce, whereas timely result is sometimes requested if fresh embryo transfer is desired. On the other hand, preimplantation genetic screening (PGS screens embryo with aneuploidy and was also known as PGD-A (A denotes aneuploidy in order to enhance the implantation rates as well as livebirth rates. In contrasts to PGD, PGS is still under ferocious debate, especially recent reports found that euploid babies were born after transferring the aneuploid embryos diagnosed by PGS back to the womb and only very few randomized trials of PGS are available in the literature. We have been doing PGD and/or PGS for more than 10 years as one of the core PGD/PGS laboratories in Taiwan. Here we provide a concise review of PGD/PGS regarding its current status, both domestically and globally, as well as its future challenges.

So Young and Already Victims of Stereotype Threat: Socio-Economic Status and Performance of 6 to 9 Years Old Children on Raven's Progressive Matrices

Science.gov (United States)

Desert, Michel; Preaux, Marie; Jund, Robin

2009-01-01

The aim of this study was to verify whether children from low socio-economic status (SES) are victims of stereotype threat. Children in first grade (6 to 7 years old) and third grade (8 to 9 years old) performed Raven's progressive matrices, an intellectual ability test commonly used by psychologists. The test was presented either with the…

The status of safety of radiation sources and security of radioactive materials in Ethiopia

International Nuclear Information System (INIS)

Gebeyehu Wolde, G.

2001-01-01

Since 1993, the National Radiation Protection Authority (NRPA) has been empowered by the 'Radiation Protection Proclamation no. 79/1993' to authorize and inspect regulated activities, issue guidelines and standards and enforce the legislation and regulations. The report describes the status of the safety of radiation sources and the security of radioactive materials in Ethiopia and the progress made towards building a sound and effective national regulatory infrastructure. Also, the report highlights the challenges and difficulties encountered and concludes by indicating the way forward towards the strategic goals. (author)

Science Education Reform in Qatar: Progress and Challenges

Science.gov (United States)

Said, Ziad

2016-01-01

Science education reform in Qatar has had limited success. In the Trends in International Mathematics and Science Study (TIMMS), Qatari 4th and 8th grade students have shown progress in science achievement, but they remain significantly below the international average. Also, in the Program for International Student Assessment (PISA), Qatari…

Safety risk management of underground engineering in China: Progress, challenges and strategies

Directory of Open Access Journals (Sweden)

Qihu Qian

2016-08-01

Full Text Available Underground construction in China is featured by large scale, high speed, long construction period, complex operation and frustrating situations regarding project safety. Various accidents have been reported from time to time, resulting in serious social impact and huge economic loss. This paper presents the main progress in the safety risk management of underground engineering in China over the last decade, i.e. (1 establishment of laws and regulations for safety risk management of underground engineering, (2 implementation of the safety risk management plan, (3 establishment of decision support system for risk management and early-warning based on information technology, and (4 strengthening the study on safety risk management, prediction and prevention. Based on the analysis of the typical accidents in China in the last decade, the new challenges in the safety risk management for underground engineering are identified as follows: (1 control of unsafe human behaviors; (2 technological innovation in safety risk management; and (3 design of safety risk management regulations. Finally, the strategies for safety risk management of underground engineering in China are proposed in six aspects, i.e. the safety risk management system and policy, law, administration, economy, education and technology.

Renewable Energy Progress Reports. Data for 2009-2010

Energy Technology Data Exchange (ETDEWEB)

Beurskens, L.W.M. [ECN Policy Studies, Petten (Netherlands)

2013-12-15

This report compiles and presents all data that were published by 27 European Member States to comply with Article 22 from the Renewable Energy Directive (2009/28/EC). These reports were due by December 2011 and present the status of renewable energy for the statistical years 2009 and 2010. The original Progress Reports are available publicly, but grabbing the data from the predefined tables is a challenge. In this report and the underlying database (both available at www.ecn.nl/nreap) all data are presented in an accessible manner. In the first part of the report the data have been grouped per country, in the second part per technology. Where possible EU-27 totals have been calculated in this second part. The report features an extensive index in order to increase its value as a reference book.

Global Status of Nuclear Power: Prospects and Challenges

International Nuclear Information System (INIS)

Tayobeka, B. M.

2010-01-01

Global energy requirements and the share of electricity in total energy consumption are increasing rapidly, and the contribution of nuclear power is projected to increase significantly. Out of the 29 countries currently using nuclear power for electricity generation, 22 intend to allow new plants to be built, and, of those, the majority are actively supporting the increased use of nuclear power, some by providing incentives. Most of these countries are expected to build reactors with a generating capacity of over 1000 MW(e). Only three countries continue to have a policy to phase out the use of nuclear energy in the future by not replacing existing operating nuclear power plants and with no consideration of the option of new nuclear plants.In addition, a growing number of countries are expressing interest in introducing nuclear power. Of the more than 60 countries that have expressed such an interest in recent years, over 20 are actively considering nuclear power programmes to meet their energy needs and the others have expressed interest in understanding the issues associated with the introduction of nuclear power.The drivers for rising expectations for nuclear power include: growing energy demand, concern over national energy supply security, the increasingly volatile price of fossil fuels and global environmental concerns. The drivers appear to be the same for countries expanding existing nuclear programmes and those seeking to introduce programmes. The projections made by different international organizations indicate a significant growth in the use of nuclear power. The IAEA projections indicate a world total for nuclear electrical generating capacity of between 445 and 543 GW(e) by 2020 and between 511 and 807 GW(e) by 2030. This paper takes a detailed look into the global status of nuclear power, highlighting challenges and prospects of the technology going into the next century.(author).

Dengue vaccines: Challenges, development, current status and prospects

Directory of Open Access Journals (Sweden)

A Ghosh

2015-01-01

Full Text Available Infection with dengue virus (DENV is the most rapidly spreading mosquito-borne viral disease in the world. The clinical spectrum of dengue, caused by any of the four serotypes of DENV, ranges from mild self-limiting dengue fever to severe dengue, in the form dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. Increased rates of hospitalization due to severe dengue, during outbreaks, result in massive economic losses and strained health services. In the absence of specific antiviral therapy, control of transmission of DENV by vector management is the sole method available for decreasing dengue-associated morbidity. Since vector control strategies alone have not been able to satisfactorily achieve reduction in viral transmission, the implementation of a safe, efficacious and cost-effective dengue vaccine as a supplementary measure is a high public health priority. However, the unique and complex immunopathology of dengue has complicated vaccine development. Dengue vaccines have also been challenged by critical issues like lack of animal models for the disease and absence of suitable markers of protective immunity. Although no licensed dengue vaccine is yet available, several vaccine candidates are under phases of development, including live attenuated virus vaccines, live chimeric virus vaccines, inactivated virus vaccines, subunit vaccines, DNA vaccines and viral-vectored vaccines. Although some vaccine candidates have progressed from animal trials to phase II and III in humans, a number of issues regarding implementation of dengue vaccine in countries like India still need to be addressed. Despite the current limitations, collaborative effects of regulatory bodies like World Health Organization with vaccine manufacturers and policy makers, to facilitate vaccine development and standardize field trials can make a safe and efficacious dengue vaccine a reality in near future.

The “New Doctorate” in Austria: Progress toward a Professional Model or Status Quo?

Directory of Open Access Journals (Sweden)

Hans Pechar

2012-01-01

Full Text Available Until recently, both policy direction and public awareness of the Bologna Process has been focused almost unilaterally on the introduction of the Bachelor’s degree to European universities. This is understandable, as for most European countries, the Bachelor is a new academic degree. However, commencing with the Berlin Ministerial Conference (Realising the European Higher Education Area, 2003, reform of doctoral studies has been highlighted as a second equal pillar in the Bologna reform process. In this paper, we begin by providing an overview of the general policy background and the rationales that underlie the attempts to restructure doctoral studies in Europe. Next, we focus on the specific situation in Austria, where peculiarities of the status quo collide with uniquely Austrian approaches to reforming doctoral education. Finally, through two case studies, we examine initial attempts – and related challenges – to implement the “New Doctorate” in Austria.

Assessment Tools as Drivers for SPI: Short-term Benefits and Long-term Challenges

DEFF Research Database (Denmark)

Mûller, Sune Dueholm; Nørbjerg, Jacob; Cho, Hiu Ngan

2007-01-01

Full scale software process maturity assessments are costly, can have large organizational impact, and are carried out at long (12-24 months) intervals. Consequently, there is a need for techniques and tools to monitor and help manage an SPI project through inexpensive, ongoing progress assessments....... In this paper we present findings from two cases of using such a tool. We have found that the tool does provide useful snapshots of the status of SPI projects, but that long-term use of the tool introduces costs and challenges related to modifying and tailoring the tool to both the organizational context...

Storming the Citadel: The Fundamental Revolution Against Progressive Education.

Science.gov (United States)

Vetterli, Richard

The first four chapters ("Progressive Education,""The Impact of Progressive Education,""The Remedies: Focusing on the Wrong Problems," and "Progressive Education Challenged") examine the deleterious effect that progressive education has had on student achievement and on society as a whole. The last five…

Egyptian women in physics: Progress and challenges

Science.gov (United States)

Mohsen, M.; Hosni, Hala; Mohamed, Hadeer; Gadalla, Afaf; Kahil, Heba; Hashem, Hassan

2015-12-01

The present study shows a progressive increase in the number of female physicists as undergraduates and postgraduates in several governmental universities. For instance, in Ain Shams University, the percentage of women who selected physics as a major course of study increased from 7.2% in 2012 to 10.8% in 2013 and 15.7% in 2014. The study also provides the current gender distribution in the various positions among the teaching staff in seven governmental universities. The data supports the fact that female teaching assistants are increasing in these universities.

Looking from Within: Prospects and Challenges for Progressive Education in Indonesia

Science.gov (United States)

Zulfikar, Teuku

2013-01-01

Many Indonesian scholars (Azra, 2002; Darmaningtyas, 2004; Yunus, 2004), have attempted to bring progressive education to their country. They believe that progressive practices such as critical thinking, critical dialogue and child-centered instruction will help students learn better. However, this implementation is resisted because of cultural…

Progress and Challenge of Artificial Intelligence

Institute of Scientific and Technical Information of China (English)

Zhong-Zhi Shi; Nan-Ning Zheng

2006-01-01

Artificial Intelligence (AI) is generally considered to be a subfield of computer science, that is concerned to attempt simulation, extension and expansion of human intelligence. Artificial intelligence has enjoyed tremendous success over the last fifty years. In this paper we only focus on visual perception, granular computing, agent computing, semantic grid. Human-level intelligence is the long-term goal of artificial intelligence. We should do joint research on basic theory and technology of intelligence by brain science, cognitive science, artificial intelligence and others. A new cross discipline intelligence science is undergoing a rapid development. Future challenges are given in final section.

Constructed Wetlands for Treatment of Combined Sewer Overflow in the US: A Review of Design Challenges and Application Status

Directory of Open Access Journals (Sweden)

Wendong Tao

2014-11-01

Full Text Available As combined sewer systems and centralized wastewater treatment facilities age, many communities in the world are challenged by management of combined sewer overflow (CSO. Constructed wetlands are considered to be one of the green infrastructure solutions to CSOs in the US. Despite the wide application of constructed wetlands to different types of wastewaters, the stochastic and intermittent nature of CSO presents challenges for design and performance assessment of constructed wetlands. This paper reviews the application status of CSO constructed wetlands in the US, assesses the benefits of CSO constructed wetlands, identifies challenges to designing CSO constructed wetlands, and proposes design considerations. This review finds that constructed wetlands are effective in CSO treatment and relatively less expensive to build than comparable grey infrastructure. Constructed wetlands not only remove pollutants, but also mitigate the event-associated flow regime. The design challenges include incorporating considerations of green infrastructure into permit requirements, determining design capacity for highly variable flows, requiring pretreatment, and needing adaptive design and intensive monitoring. Simultaneous monitoring of flow rate and water quality at both the inflow and outflow of CSO constructed wetlands is required for performance assessment and needed to support design, but is rarely available.

Present status and future challenges of nuclear forensics technology developments in JAEA

International Nuclear Information System (INIS)

Kimura, Yoshiki; Shinohara, Nobuo; Okubo, Ayako; Toda, Nobufumi; Funatake, Yoshio; Kataoka, Osamu; Matsumoto, Tetsuya; Watahiki, Masaru; Kuno, Yusuke

2014-01-01

Japan Atomic Energy Agency (JAEA) has started a nuclear forensics (NF) technology development project from JFY 2011, according to the National Statement of Japan in Nuclear Security Summit 2010. This paper will present the progress and future prospects of the development project during JFY 2011 to 2013. The project on NF technology in JAEA includes the development of analytical technologies such as isotope and impurity measurements, morphology analysis, age determination technique, and the prototype of nuclear forensics library (NFL) for future national NFL. Some analytical devices were installed for the analytical technology developments, and various uranium materials produced in JAEA facilities at Ningyo-toge have been measured to verify the analytical technologies. A nuclear material database of the prototype NFL was also developed with brief tools of multivariate analysis and image analysis. The implementation of the analytical technologies, the development of advanced analytical technologies and the system improvements of the prototype NFL will be continued from JFY 2014 in JAEA. The national regime and national response plan are remained as a big challenge to establish the national NF capabilities in Japan. (author)

Development status of nuclear power in China and fundamental research progress on PWR primary water chemistry in China

International Nuclear Information System (INIS)

Wu, Xinqiang; Liu, Xiahe; Han, En-Hou; Ke, Wei; Xu, Yuming

2015-01-01

China's non-fossil fuels are expected to reach 20% in primary energy ratio by 2030. It is urgent for China to speed up the development of nuclear power to increase energy supply, reduce gas emissions and optimize resource allocation. Chinese government slowed down the approval of new nuclear power plant (NPP) projects after Fukushima accident in 2011. At the end of 2012, the State Council approved the nuclear safety program and adjusted long-term nuclear power development plan (2011-2020), the new NPP's projects have been restarted. In June 2015, there are 23 operating units in mainland in China with total installed capacity of about 21.386 GWe; another 26 units are under construction with total installed capacity of 28.5 GWe. The main type of reactors in operation and under construction in China is pressurized water reactor (PWR), including the first AP1000 NPPs in the world (units 1 in Sanmen) and China self-developed Hualong one NPPs (units 5 and 6 in Fuqing). Currently, China's nuclear power development is facing historic opportunities and also a series of challenges. One of the most important is the safety and economy of nuclear power. The optimization of primary water chemistry is one of the most effective ways to minimize radiation field, mitigate material degradation and maintain fuel performance in PWR NPPs, which is also a preferred path to achieve both safety and economy for operating NPPs. In recent years, an increased attention has been paid to fundamental research and engineering application of PWR primary water chemistry in China. The present talk mainly consists of four parts: (1) development status of China's nuclear power industry; (2) safety of nuclear power and operating water chemistry; (3) fundamental research progress on Zn-injected water chemistry in China; (4) summary and future. (author)

Nuclear challenges and progress in designing stellarator power plants

International Nuclear Information System (INIS)

El-Guebaly, L.

2007-01-01

As an alternate to the mainline magnetic fusion tokamaks, the stellarator concept offers a steady state operation without external driven current, eliminating the risk of plasma irruptions. Over the past 2-3 decades, stellarator power plants have been studied in the U.S., Japan, and Europe to enhance the physics and engineering aspects and optimize the design parameters that are subject to numerous constraints. The earlier 1980's studies delivered large stellarators with an average major radius exceeding 20 m. The most recent development of the compact stellarator concept has led to the construction of the National Compact Stellarator Experiment (NCSX) in the U.S. and the 3 years power plant study of ARIES-CS, a compact stellarator with 7.75 m average major radius, approaching that of tokamaks. The ARIES-CS first wall configuration deviates from the standard practice of uniform toroidal shape in order to achieve compactness. Modeling such a complex geometry for 3-D nuclear analysis was a challenging engineering task. A novel approach based on coupling the CAD model with the MCNP Monte Carlo code was developed to model, for the first time ever, the complex stellarator geometry for nuclear assessments. The most important parameter that determines the stellarator size and cost is the minimum distance between the plasma boundary and mid-coil. Accommodating the breeding blanket and necessary shield to protect the superconducting magnet represented another challenging task. An innovative approach utilizing a non-uniform blanket combined with a highly efficient WC shield for this highly constrained area reduced the radial standoff (and machine size and cost) by 25- 30%, which is significant. As stellarators generate more radwaste than tokamaks, managing ARIES-CS active materials during operation and after plant decommissioning was essential for the environmental attractiveness of the machine. The geological disposal option could be replaced with more attractive scenarios

Fifth annual progress report for Canada's climate change voluntary challenge and registry program

International Nuclear Information System (INIS)

1999-10-01

Suncor Energy is a growing Canada-based integrated energy company comprising a corporate group and four operating businesses including: Oil Sands with a mine and upgrading facility at Fort McMurray, AB, Exploration and Production with conventional and heavy oil business in Western Canada, a Sunoco refining and marketing operation, and the Stuart Oil Shale Development Project in Queensland, Australia. While the emphasis is laid on technical and economic advances made by the company, the environmental tradeoffs, namely, greater greenhouse gas emissions and the need to reduce them, are noted. The most important positive item in the report is the incredible transformation occurring in Suncor's business operations. The company has begun a $2 billion expansion in its Oil Sands business that will more than double production of crude oil and fuel products by 2002. The expansion initiative provides a wonderful opportunity to demonstrate the huge leaps in performance that can be implemented at the time of capital stock turnover. The new expansion facilities are designed to be twice as energy efficient as the existing plant. Equally dramatic and hard won, are the multitude of incremental improvements achieved in existing facilities. Through energy management systems and operating practices and procedures, exploration and production is reversing the trend of rising greenhouse gas (GHG) emission intensity associated with mature conventional reservoirs, and Suncoco achieved its best ever operating performance in 1998. However, the volume of Suncor greenhouse gas emissions remains on an upward trend, which is a challenge for the future. As part of its mission to become a sustainable energy company, Suncor will continue to attempt to limit its net volume contribution of GHGs to the atmosphere to 1990 levels by pursuing domestic and international offsets and the development of alternative and renewable sources of energy. Progress towards sustainability for both Suncor and Canada

Public Service Motivation Research : Achievements, Challenges, and Future Directions

NARCIS (Netherlands)

Perry, James L.; Vandenabeele, Wouter

2015-01-01

This article takes stock of public service motivation research to identify achievements, challenges, and an agenda for research to build on progress made since 1990. After enumerating achievements and challenges, the authors take stock of progress on extant proposals to strengthen research. In

Progress and challenges in improving the nutritional quality of rice (Oryza sativa L.).

Science.gov (United States)

Birla, Deep Shikha; Malik, Kapil; Sainger, Manish; Chaudhary, Darshna; Jaiwal, Ranjana; Jaiwal, Pawan K

2017-07-24

Rice is a staple food for more than 3 billion people in more than 100 countries of the world but ironically it is deficient in many bioavailable vitamins, minerals, essential amino- and fatty-acids and phytochemicals that prevent chronic diseases like type 2 diabetes, heart disease, cancers, and obesity. To enhance the nutritional and other quality aspects of rice, a better understanding of the regulation of the processes involved in the synthesis, uptake, transport, and metabolism of macro-(starch, seed storage protein and lipid) and micronutrients (vitamins, minerals and phytochemicals) is required. With the publication of high quality genomic sequence of rice, significant progress has been made in identification, isolation, and characterization of novel genes and their regulation for the nutritional and quality enhancement of rice. During the last decade, numerous efforts have been made to refine the nutritional and other quality traits either by using the traditional breeding with high through put technologies such as marker assisted selection and breeding, or by adopting the transgenic approach. A significant improvement in vitamins (A, folate, and E), mineral (iron), essential amino acid (lysine), and flavonoids levels has been achieved in the edible part of rice, i.e., endosperm (biofortification) to meet the daily dietary allowance. However, studies on bioavailability and allergenicity on biofortified rice are still required. Despite the numerous efforts, the commercialization of biofortified rice has not yet been achieved. The present review summarizes the progress and challenges of genetic engineering and/or metabolic engineering technologies to improve rice grain quality, and presents the future prospects in developing nutrient dense rice to save the everincreasing population, that depends solely on rice as the staple food, from widespread nutritional deficiencies.

The ketogenic diet as broad-spectrum treatment for super-refractory pediatric status epilepticus: challenges in implementation in the pediatric and neonatal intensive care units.

Science.gov (United States)

Cobo, Nicole H; Sankar, Raman; Murata, Kristina K; Sewak, Sarika L; Kezele, Michele A; Matsumoto, Joyce H

2015-02-01

Refractory status epilepticus carries significant morbidity and mortality. Recent reports have promoted the use of the ketogenic diet as an effective treatment for refractory status epilepticus. We describe our recent experience with instituting the ketogenic diet for 4 critically ill children in refractory status epilepticus, ranging in age from 9 weeks to 13.5 years after failure of traditional treatment. The ketogenic diet allowed these patients to be weaned off continuous infusions of anesthetics without recurrence of status epilepticus, though delayed ketosis and persistently elevated glucose measurements posed special challenges to effective initiation, and none experienced complete seizure cessation. The ease of sustaining myocardial function with fatty acid energy substrates compares favorably over the myocardial toxicity posed by anesthetic doses of barbiturates and contributes to the safety profile of the ketogenic diet. The ketogenic diet can be implemented successfully and safely for the treatment of refractory status epilepticus in pediatric patients. © The Author(s) 2014.

Challenges and progress in turbomachinery design systems

International Nuclear Information System (INIS)

Van den Braembussche, R A

2013-01-01

This paper first describes the requirements that a modern design system should meet, followed by a comparison between design systems based on inverse design or optimization techniques. The second part of the paper presents the way these challenges are realized in an optimization method combining an Evolutionary theory and a Metamodel. Extensions to multi-disciplinary, multi-point and multi-objective optimization are illustrated by examples

Methodological challenges in assessing the environmental status of a marine ecosystem: case study of the Baltic Sea.

Directory of Open Access Journals (Sweden)

Henn Ojaveer

Full Text Available Assessments of the environmental status of marine ecosystems are increasingly needed to inform management decisions and regulate human pressures to meet the objectives of environmental policies. This paper addresses some generic methodological challenges and related uncertainties involved in marine ecosystem assessment, using the central Baltic Sea as a case study. The objectives of good environmental status of the Baltic Sea are largely focusing on biodiversity, eutrophication and hazardous substances. In this paper, we conduct comparative evaluations of the status of these three segments, by applying different methodological approaches. Our analyses indicate that the assessment results are sensitive to a selection of indicators for ecological quality objectives that are affected by a broad spectrum of human activities and natural processes (biodiversity, less so for objectives that are influenced by a relatively narrow array of drivers (eutrophications, hazardous substances. The choice of indicator aggregation rule appeared to be of essential importance for assessment results for all three segments, whereas the hierarchical structure of indicators had only a minor influence. Trend-based assessment was shown to be a useful supplement to reference-based evaluation, being independent of the problems related to defining reference values and indicator aggregation methodologies. Results of this study will help in setting priorities for future efforts to improve environmental assessments in the Baltic Sea and elsewhere, and to ensure the transparency of the assessment procedure.

6 CFR 7.30 - Classification challenges.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Classification challenges. 7.30 Section 7.30... INFORMATION Classified Information § 7.30 Classification challenges. (a) Authorized holders of information... classified are encouraged and expected to challenge the classification status of that information pursuant to...

Engineering of obligate intracellular bacteria: progress, challenges and paradigms

Science.gov (United States)

Over twenty years have passed since the first report of genetic manipulation of an obligate intracellular bacterium. Through progress interspersed by bouts of stagnation, microbiologists and geneticists have developed approaches to genetically manipulate obligates. A brief overview of the current ge...

Recruiting older patients with peripheral arterial disease: evaluating challenges and strategies.

Science.gov (United States)

Brostow, Diana P; Hirsch, Alan T; Kurzer, Mindy S

2015-01-01

Peripheral arterial disease (PAD) is a group of syndromes characterized by chronic and progressive atherosclerosis with a high burden of physical disability and cardiovascular morbidity and mortality. Recruiting patients for clinical research is therefore challenging. In this article, we describe and evaluate our methods for recruiting participants for a cross-sectional feasibility study of PAD, nutritional status, and body composition. We used convenience and purposive sampling approaches to identify potential participants. Between May 2012 and April 2013, 1,446 patients were identified, and 165 patients (11.4%) responded to recruitment requests. The final enrollment was 64 participants (64/1,446; 4.4%), and four subjects (6.3%) subsequently withdrew from the study. Recruiting PAD patients presents a variety of challenges, due largely to the burdens of living with coexistent illnesses, and patients' reluctance or inability to travel for research. In this article, we delineate suggestions for improving the efficacy of recruitment methods in future PAD studies.

Real-time fMRI neurofeedback: Progress and challenges

Science.gov (United States)

Sulzer, J.; Haller, S.; Scharnowski, F.; Weiskopf, N.; Birbaumer, N.; Blefari, M.L.; Bruehl, A.B.; Cohen, L.G.; deCharms, R.C.; Gassert, R.; Goebel, R.; Herwig, U.; LaConte, S.; Linden, D.; Luft, A.; Seifritz, E.; Sitaram, R.

2016-01-01

In February of 2012, the first international conference on real time functional magnetic resonance imaging (rtfMRI) neurofeedback was held at the Swiss Federal Institute of Technology Zurich (ETHZ), Switzerland. This review summarizes progress in the field, introduces current debates, elucidates open questions, and offers viewpoints derived from the conference. The review offers perspectives on study design, scientific and clinical applications, rtfMRI learning mechanisms and future outlook. PMID:23541800

Coupled Atmosphere-Wave-Ocean Modeling of Tropical Cyclones: Progress, Challenges, and Ways Forward

Science.gov (United States)

Chen, Shuyi

2015-04-01

/s. It is found that the air-sea fluxes are quite asymmetric around a storm with complex features representing various air-sea interaction processes in TCs. A unique observation in Typhoon Fanapi is the development of a stable boundary layer in the near-storm cold wake region, which has a direct impact on TC inner core structure and intensity. Despite of the progress, challenges remain. Air-sea momentum exchange in wind speed greater than 30-40 m/s is largely unresolved. Directional wind-wave stress and wave-current stress are difficult to determine from observations. Effects of sea spray on the air-sea fluxes are still not well understood. This talk will provide an overview on progress made in recent years, challenges we are facing, and ways forward. An integrated coupled observational and atmosphere-wave-ocean modeling system is urgently needed, in which coupled model development and targeted observations from field campaign and lab measurements together form the core of the research and prediction system. Another important aspect is that fully coupled models provide explicit, integrated impact forecasts of wind, rain, waves, ocean currents and surges in TCs and winter storms, which are missing in most current NWP models. It requires a new strategy for model development, evaluation, and verification. Ensemble forecasts using high-resolution coupled atmosphere-wave-ocean models can provide probabilistic forecasts and quantitative uncertainty estimates, which also allow us to explore new methodologies to verify probabilistic impact forecasts and evaluate model physics using a stochastic approach. Examples of such approach in TCs including Superstorm Sandy will be presented.

13 CFR 127.601 - May a protest challenging the size and status of a concern as an EDWOSB or WOSB be filed together?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false May a protest challenging the size and status of a concern as an EDWOSB or WOSB be filed together? 127.601 Section 127.601 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION WOMEN-OWNED SMALL BUSINESS FEDERAL CONTRACT...

Progressive Encephalomyelitis with Rigidity and Myoclonus in an Intellectually Disabled Patient Mimicking Neuroleptic Malignant Syndrome

Directory of Open Access Journals (Sweden)

Zheyu Xu

2017-05-01

Full Text Available We present a case of 32-year-old male with profound mental retardation and autism spectrum disorder who had presented with seizures, rigidity and elevated creatine kinase and was initially diagnosed as neuroleptic malignant syndrome (NMS. The patient subsequently had a complicated clinical course, developing refractory status epilepticus, which lead to the eventual diagnosis of progressive encephalomyelitis with rigidity and myoclonus (PERM. We discuss the clinical similarities and differences between NMS and PERM, and highlight the need to consider alternative diagnoses when the clinical picture of NMS is atypical, particularly in this patient group where the history and clinical examination may be challenging.

Status of Early-Career Academic Cardiology: A Global Perspective.

Science.gov (United States)

Tong, Carl W; Madhur, Meena S; Rzeszut, Anne K; Abdalla, Marwah; Abudayyeh, Islam; Alexanderson, Erick; Buber, Jonathan; Feldman, Dmitriy N; Gopinathannair, Rakesh; Hira, Ravi S; Kates, Andrew M; Kessler, Thorsten; Leung, Steve; Raj, Satish R; Spatz, Erica S; Turner, Melanie B; Valente, Anne Marie; West, Kristin; Sivaram, Chittur A; Hill, Joseph A; Mann, Douglas L; Freeman, Andrew M

2017-10-31

Early-career academic cardiologists, who many believe are an important component of the future of cardiovascular care, face myriad challenges. The Early Career Section Academic Working Group of the American College of Cardiology, with senior leadership support, assessed the progress of this cohort from 2013 to 2016 with a global perspective. Data consisted of accessing National Heart, Lung, and Blood Institute public information, data from the American Heart Association and international organizations, and a membership-wide survey. Although the National Heart, Lung, and Blood Institute increased funding of career development grants, only a small number of early-career American College of Cardiology members have benefited as funding of the entire cohort has decreased. Personal motivation, institutional support, and collaborators continued to be positive influential factors. Surprisingly, mentoring ceased to correlate positively with obtaining external grants. The totality of findings suggests that the status of early-career academic cardiologists remains challenging; therefore, the authors recommend a set of attainable solutions. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Poverty Reduction and Shared Prosperity in Moldova : Progress and Prospects

OpenAIRE

World Bank Group

2016-01-01

Moldova has experienced rapid economic growth in the past decade, which has been accompanied by reductions in poverty and good performance in shared prosperity. Nonetheless, Moldova remains one of the poorest countries in Europe and faces challenges in sustaining the progress. The challenges for progress include spatial and cross-group inequalities, particularly because of unequal access t...

Present status and expected progress in radiation processing dosimetry

DEFF Research Database (Denmark)

Kovács, A.; Miller, A.

2004-01-01

The paper describes the present status of radiation processing dosimetry including the methods used most widely in gamma- and electron processing as well as the new methods under development or introduction. The recent trends with respect to calibrationof routine dosimetry systems as well...

Computational pan-genomics: status, promises and challenges

NARCIS (Netherlands)

The Computational Pan-Genomics Consortium; T. Marschall (Tobias); M. Marz (Manja); T. Abeel (Thomas); L.J. Dijkstra (Louis); B.E. Dutilh (Bas); A. Ghaffaari (Ali); P. Kersey (Paul); W.P. Kloosterman (Wigard); V. Mäkinen (Veli); A.M. Novak (Adam); B. Paten (Benedict); D. Porubsky (David); E. Rivals (Eric); C. Alkan (Can); J.A. Baaijens (Jasmijn); P.I.W. de Bakker (Paul); V. Boeva (Valentina); R.J.P. Bonnal (Raoul); F. Chiaromonte (Francesca); R. Chikhi (Rayan); F.D. Ciccarelli (Francesca); C.P. Cijvat (Robin); E. Datema (Erwin); C.M. van Duijn (Cornelia); E.E. Eichler (Evan); C. Ernst (Corinna); E. Eskin (Eleazar); E. Garrison (Erik); M. El-Kebir (Mohammed); G.W. Klau (Gunnar); J.O. Korbel (Jan); E.-W. Lameijer (Eric-Wubbo); B. Langmead (Benjamin); M. Martin; P. Medvedev (Paul); J.C. Mu (John); P.B.T. Neerincx (Pieter); K. Ouwens (Klaasjan); P. Peterlongo (Pierre); N. Pisanti (Nadia); S. Rahmann (Sven); B.J. Raphael (Benjamin); K. Reinert (Knut); D. de Ridder (Dick); J. de Ridder (Jeroen); M. Schlesner (Matthias); O. Schulz-Trieglaff (Ole); A.D. Sanders (Ashley); S. Sheikhizadeh (Siavash); C. Shneider (Carl); S. Smit (Sandra); D. Valenzuela (Daniel); J. Wang (Jiayin); L.F.A. Wessels (Lodewyk); Y. Zhang (Ying); V. Guryev (Victor); F. Vandin (Fabio); K. Ye (Kai); A. Schönhuth (Alexander)

2018-01-01

textabstractMany disciplines, from human genetics and oncology to plant breeding, microbiology and virology, commonly face the challenge of analyzing rapidly increasing numbers of genomes. In case of Homo sapiens, the number of sequenced genomes will approach hundreds of thousands in the next few

Recent progress and future challenges in algal biofuel production [version 1; referees: 4 approved

Directory of Open Access Journals (Sweden)

Jonathan B. Shurin

2016-10-01

Full Text Available Modern society is fueled by fossil energy produced millions of years ago by photosynthetic organisms. Cultivating contemporary photosynthetic producers to generate energy and capture carbon from the atmosphere is one potential approach to sustaining society without disrupting the climate. Algae, photosynthetic aquatic microorganisms, are the fastest growing primary producers in the world and can therefore produce more energy with less land, water, and nutrients than terrestrial plant crops. We review recent progress and challenges in developing bioenergy technology based on algae. A variety of high-value products in addition to biofuels can be harvested from algal biomass, and these may be key to developing algal biotechnology and realizing the commercial potential of these organisms. Aspects of algal biology that differentiate them from plants demand an integrative approach based on genetics, cell biology, ecology, and evolution. We call for a systems approach to research on algal biotechnology rooted in understanding their biology, from the level of genes to ecosystems, and integrating perspectives from physical, chemical, and social sciences to solve one of the most critical outstanding technological problems.

The LHC Project Status and Prospects

CERN Document Server

Faugeras, Paul E

2001-01-01

The Large Hadron Collider (LHC), CERN's future major facility for high-energy physics, has entered into the construction and preparation for installation phases. After recalling briefly the main machine design choices and challenges, one will review the progress of civil works for the machine and experimental areas and the status of the main LHC components, which are presently series-built and for some of them procured in kind through world-wide collaborations. Report will also be given on the full-scale prototype of an elementary LHC lattice cell, called String 2, which is being commissioned and used for optimising the installation and testing procedures of the LHC. The size and duration of the LHC Project, its intrinsic complexity and the large number of world-wide collaborations involved require rather elaborate project management tools, which will be shortly described. Finally, following the extended running of the LEP and the delay for emptying of the machine tunnel, a new planning for project completion...

Sustainable Tourism: Progress Challenges and Opportunities

DEFF Research Database (Denmark)

Budeanu, Adriana; Miller, Graham; Moscardo, Gianna

2016-01-01

The term sustainable tourism emerged in the late 1980s and has become firmly established in both tourism policies and strategies and tourism research (Hall, 2011). After more than 25 years of attention it is timely to consider the state of research and practice in sustainable tourism. This special...... volume was established with exactly that goal in mind and this introduction seeks to set the context for this critical examination and reflection on sustainable tourism. Another objective of this introduction was to briefly describe the range of contributions selected for this SV. The articles...... are organised into four thematic areas of research: community stakeholders' perspectives and business approaches to sustainability in tourism, cultural responses, and methodological challenges related to sustainability. The articles shine a light on issues of importance within sustainable tourism, and in so...

Language development: Progress and challenges in a multilingual ...

African Journals Online (AJOL)

Some such challenges discussed include issues like language selection for development, absence of clear language policy and the important issue of attitudes of respective language communities towards language research programmes. The article also looks at how the project and the institute have managed to make ...

Status and future prospects of SRF gun developments

International Nuclear Information System (INIS)

Teichert, Jochen

2006-01-01

While the concepts of DC and normal-conducting photo-injectors are well proofed, the SRF gun development still possesses a high risk. Challenges are the thermal and contaminant isolation needed between the cathode and superconducting cavity, the choice of the right photocathode and its life time, the difficulty of coupling high-average power into the gun, and beam excitation of higher order cavity modes. But in combination with SRF linacs, the SRF guns are the best solution for high current and CW operation. Thus, several R and D projects of SRF gun have been launched. The talk will give an overview of the history and progress of the SRF gun development. In more detail the technical concept, performance, and status of the Rossendorf superconducting RF gun project, a collaboration of BESSY, DESY, MBI and FZR, will be presented. (author)

Status and neutron scattering experiments at KENS

International Nuclear Information System (INIS)

Watanabe, N.; Sasaki, H.; Ishikawa, Y.; Endoh, Y.; Inoue, K.

1983-01-01

This paper reports present status of the KENS facility, progress in neutron scattering experiments and instrumental developments, and status of the KENS-I' program. A design study of a high intensity rapid-cycle 800 MeV proton synchrotron for proposed new pulsed neutron (KENS-II) and meson source is also descirbed

Review article: Hydrological modeling in glacierized catchments of central Asia - status and challenges

Science.gov (United States)

Chen, Yaning; Li, Weihong; Fang, Gonghuan; Li, Zhi

2017-02-01

Meltwater from glacierized catchments is one of the most important water supplies in central Asia. Therefore, the effects of climate change on glaciers and snow cover will have increasingly significant consequences for runoff. Hydrological modeling has become an indispensable research approach to water resources management in large glacierized river basins, but there is a lack of focus in the modeling of glacial discharge. This paper reviews the status of hydrological modeling in glacierized catchments of central Asia, discussing the limitations of the available models and extrapolating these to future challenges and directions. After reviewing recent efforts, we conclude that the main sources of uncertainty in assessing the regional hydrological impacts of climate change are the unreliable and incomplete data sets and the lack of understanding of the hydrological regimes of glacierized catchments of central Asia. Runoff trends indicate a complex response to changes in climate. For future variation of water resources, it is essential to quantify the responses of hydrologic processes to both climate change and shrinking glaciers in glacierized catchments, and scientific focus should be on reducing uncertainties linked to these processes.

Standardized Treatment of Neonatal Status Epilepticus Improves Outcome.

Science.gov (United States)

Harris, Mandy L; Malloy, Katherine M; Lawson, Sheena N; Rose, Rebecca S; Buss, William F; Mietzsch, Ulrike

2016-12-01

We aimed to decrease practice variation in treatment of neonatal status epilepticus by implementing a standardized protocol. Our primary goal was to achieve 80% adherence to the algorithm within 12 months. Secondary outcome measures included serum phenobarbital concentrations, number of patients progressing from seizures to status epilepticus, and length of hospital stay. Data collection occurred for 6 months prior and 12 months following protocol implementation. Adherence of 80% within 12 months was partially achieved in patients diagnosed in our hospital; in pretreated patients, adherence was not achieved. Maximum phenobarbital concentrations were decreased (56.8 vs 41.0 µg/mL), fewer patients progressed from seizures to status epilepticus (46% vs 36%), and hospital length of stay decreased by 9.7 days in survivors. In conclusion, standardized, protocol-driven treatment of neonatal status epilepticus improves consistency and short-term outcome. © The Author(s) 2016.

The challenge of merging : Merger patterns, premerger status, and merger support

NARCIS (Netherlands)

Giessner, [No Value; Täuber, Susanne; Viki, GT; Otten, S; Terry, DJ; Giessner, S.R

Employees of merging organizations often show resistance to the merger. The employees' support depends on the companies' premerger status and on the merger pattern. Based on an inter-group perspective, three studies were conducted to investigate the influence of premerger status (high, low) and

Stable isotope views on ecosystem function: challenging or challenged?

Science.gov (United States)

Resco, Víctor; Querejeta, José I; Ogle, Kiona; Voltas, Jordi; Sebastià, Maria-Teresa; Serrano-Ortiz, Penélope; Linares, Juan C; Moreno-Gutiérrez, Cristina; Herrero, Asier; Carreira, José A; Torres-Cañabate, Patricia; Valladares, Fernando

2010-06-23

Stable isotopes and their potential for detecting various and complex ecosystem processes are attracting an increasing number of scientists. Progress is challenging, particularly under global change scenarios, but some established views have been challenged. The IX meeting of the Spanish Association of Terrestrial Ecology (AAET, Ubeda, 18-22 October 2009) hosted a symposium on the ecology of stable isotopes where the linear mixing model approach of partitioning sinks and sources of carbon and water fluxes within an ecosystem was challenged, and new applications of stable isotopes for the study of plant interactions were evaluated. Discussion was also centred on the need for networks that monitor ecological processes using stable isotopes and key ideas for fostering future research with isotopes.

Status of the HIRFL–CSR complex

International Nuclear Information System (INIS)

Yuan, Y.J.; Yang, J.C.; Xia, J.W.; Yuan, P.; Qiao, W.M.; Gao, D.Q.; Xiao, G.Q.; Zhao, H.W.; Xu, H.S.; Song, M.T.; Yang, X.D.; Cai, X.H.; Ma, L.Z.; Yang, X.T.; Man, K.T.; He, Y.; Zhou, Z.Z.; Zhang, J.H.; Xu, Z.; Liu, Y.

2013-01-01

Highlights: • HIRFL is in a very positive state and can provide all ion species with maximum energy to 1 GeV/u (A/q = 2). • Present status of HIRFL complex is given as well as the new progress on operation and improvement. • With emphasize on HIRFL–CSR project, main features realized during the commissioning and operation are described in detail. • The progress on physics experiments and hadron cancer therapy are also presented. -- Abstract: The HIRFL–CSR, as an upgrade of the HIRFL, has been put into operation since 2008. Together with a series of improvements of injector cyclotrons, the HIRFL is in a very good state and can provide all ion species from proton to uranium with energy variable from ion source energy to 1 GeV/u (A/q = 2). Present status of the HIRFL–CSR complex is given. Main features realized during the commissioning and operation are described in detail. The progress on physics experiments and cancer therapy are also presented

Gatlinburg conference: barometer of progress in analytical chemistry

International Nuclear Information System (INIS)

Shults, W.D.

1981-01-01

Much progress has been made in the field of analytical chemistry over the past twenty-five years. The AEC-ERDA-DOE family of laboratories contributed greatly to this progress. It is not surprising then to find a close correlation between program content of past Gatlinburg conferences and developments in analytical methodology. These conferences have proved to be a barometer of technical status

Progress in Harmonizing Tiered HIV Laboratory Systems: Challenges and Opportunities in 8 African Countries.

Science.gov (United States)

Williams, Jason; Umaru, Farouk; Edgil, Dianna; Kuritsky, Joel

2016-09-28

In 2014, the Joint United Nations Programme on HIV/AIDS released its 90-90-90 targets, which make laboratory diagnostics a cornerstone for measuring efforts toward the epidemic control of HIV. A data-driven laboratory harmonization and standardization approach is one way to create efficiencies and ensure optimal laboratory procurements. Following the 2008 "Maputo Declaration on Strengthening of Laboratory Systems"-a call for government leadership in harmonizing tiered laboratory networks and standardizing testing services-several national ministries of health requested that the United States Government and in-country partners help implement the recommendations by facilitating laboratory harmonization and standardization workshops, with a primary focus on improving HIV laboratory service delivery. Between 2007 and 2015, harmonization and standardization workshops were held in 8 African countries. This article reviews progress in the harmonization of laboratory systems in these 8 countries. We examined agreed-upon instrument lists established at the workshops and compared them against instrument data from laboratory quantification exercises over time. We used this measure as an indicator of adherence to national procurement policies. We found high levels of diversity across laboratories' diagnostic instruments, equipment, and services. This diversity contributes to different levels of compliance with expected service delivery standards. We believe the following challenges to be the most important to address: (1) lack of adherence to procurement policies, (2) absence or limited influence of a coordinating body to fully implement harmonization proposals, and (3) misalignment of laboratory policies with minimum packages of care and with national HIV care and treatment guidelines. Overall, the effort to implement the recommendations from the Maputo Declaration has had mixed success and is a work in progress. Program managers should continue efforts to advance the

Progress in Harmonizing Tiered HIV Laboratory Systems: Challenges and Opportunities in 8 African Countries

Science.gov (United States)

Williams, Jason; Umaru, Farouk; Edgil, Dianna; Kuritsky, Joel

2016-01-01

ABSTRACT In 2014, the Joint United Nations Programme on HIV/AIDS released its 90-90-90 targets, which make laboratory diagnostics a cornerstone for measuring efforts toward the epidemic control of HIV. A data-driven laboratory harmonization and standardization approach is one way to create efficiencies and ensure optimal laboratory procurements. Following the 2008 “Maputo Declaration on Strengthening of Laboratory Systems”—a call for government leadership in harmonizing tiered laboratory networks and standardizing testing services—several national ministries of health requested that the United States Government and in-country partners help implement the recommendations by facilitating laboratory harmonization and standardization workshops, with a primary focus on improving HIV laboratory service delivery. Between 2007 and 2015, harmonization and standardization workshops were held in 8 African countries. This article reviews progress in the harmonization of laboratory systems in these 8 countries. We examined agreed-upon instrument lists established at the workshops and compared them against instrument data from laboratory quantification exercises over time. We used this measure as an indicator of adherence to national procurement policies. We found high levels of diversity across laboratories’ diagnostic instruments, equipment, and services. This diversity contributes to different levels of compliance with expected service delivery standards. We believe the following challenges to be the most important to address: (1) lack of adherence to procurement policies, (2) absence or limited influence of a coordinating body to fully implement harmonization proposals, and (3) misalignment of laboratory policies with minimum packages of care and with national HIV care and treatment guidelines. Overall, the effort to implement the recommendations from the Maputo Declaration has had mixed success and is a work in progress. Program managers should continue efforts to

Experimental status of quantum electrodynamics

International Nuclear Information System (INIS)

Drell, S.D.

1978-10-01

This review of the experimental status of quantum electrodynamics covers the fine structure constant, the muon g-2 value, the Lamb shift in hydrogen, the finite proton radius, progress in muonium, and positronium. 37 references

Interdisciplinary and physics challenges of network theory

Science.gov (United States)

Bianconi, Ginestra

2015-09-01

Network theory has unveiled the underlying structure of complex systems such as the Internet or the biological networks in the cell. It has identified universal properties of complex networks, and the interplay between their structure and dynamics. After almost twenty years of the field, new challenges lie ahead. These challenges concern the multilayer structure of most of the networks, the formulation of a network geometry and topology, and the development of a quantum theory of networks. Making progress on these aspects of network theory can open new venues to address interdisciplinary and physics challenges including progress on brain dynamics, new insights into quantum technologies, and quantum gravity.

Radioactive waste management in Canada: progress and challenges 15 years after the policy framework

International Nuclear Information System (INIS)

McCauley, D.

2011-01-01

from that development - the establishment of the Nuclear Waste Management Organization, the study of options for the long-term management of nuclear fuel waste, the Government's decision on the options, the agreement on a funding formula for nuclear fuel waste management, and the launch of the NWMO's siting process. In this same period, we also have witnessed progress on a long-term waste management facility for low and intermediate-level radioactive waste in Ontario - including an agreement with the hosting community. In addition, there has been further advancement in the management of uranium tailing, notably the launch of cleanup efforts at the Gunnar mine in northern Saskatchewan. Finally, the federal government has established robust programs for the management of historic and legacy wastes across the country. In terms of historic wastes, the Port Hope Area Initiative has advanced to the point where critical decisions will be made in 2011 on the launch of the implementation phase of that Project and the Low-Level Radioactive Waste Management Office continues to manage historic wastes at other sites across the country. As for legacy wastes, decisions are expected prior to the end of 2010 on the continuation of the Nuclear Legacy Liabilities Program which addresses decommissioning and radioactive waste liabilities at AECL sites in Manitoba, Ontario, Quebec, and Nova Scotia. The coming years will see the further advancement of these initiatives, all which will face their own challenges. Nevertheless, there is generally a defined strategy or path and the appropriate elements are in place to achieve success. Despite these initiatives, there remain gaps in Canada's approach to radioactive waste management. In particular, while there has been progress on the management of low and intermediate-level radioactive waste in Ontario to address wastes from Ontario Power Generation's facilities, there is, as yet, no long-term management approach defined for

The natural history of primary progressive multiple sclerosis

NARCIS (Netherlands)

Koch, Marcus; Kingwell, Elaine; Rieckmann, Peter; Tremlett, Helen

2009-01-01

Background: Primary progressive multiple sclerosis (PPMS) carries the worst prognosis of the multiple sclerosis (MS) subtypes and is currently untreatable. A previous analysis of the British Columbia MS database challenged the view that disability progression is rapid in PPMS, but identified few

Current status of gene therapy for breast cancer: progress and challenges

Directory of Open Access Journals (Sweden)

McCrudden CM

2014-11-01

Full Text Available Cian M McCrudden, Helen O McCarthySchool of Pharmacy, Queen’s University Belfast, Belfast, UKAbstract: Breast cancer is characterized by a series of genetic mutations and is therefore ideally placed for gene therapy intervention. The aim of gene therapy is to deliver a nucleic acid-based drug to either correct or destroy the cells harboring the genetic aberration. More recently, cancer gene therapy has evolved to also encompass delivery of RNA interference technologies, as well as cancer DNA vaccines. However, the bottleneck in creating such nucleic acid pharmaceuticals lies in the delivery. Deliverability of DNA is limited as it is prone to circulating nucleases; therefore, numerous strategies have been employed to aid with biological transport. This review will discuss some of the viral and nonviral approaches to breast cancer gene therapy, and present the findings of clinical trials of these therapies in breast cancer patients. Also detailed are some of the most recent developments in nonviral approaches to targeting in breast cancer gene therapy, including transcriptional control, and the development of recombinant, multifunctional bio-inspired systems. Lastly, DNA vaccines for breast cancer are documented, with comment on requirements for successful pharmaceutical product development.Keywords: breast cancer, gene therapy, nonviral, clinical trial

The Ignition Physics Campaign on NIF: Status and Progress

International Nuclear Information System (INIS)

Edwards, M. J.

2016-01-01

We have made significant progress in ICF implosion performance on NIF since the 2011 IFSA. Employing a 3-shock, high adiabat CH (“High-Foot”) design, total neutron yields have increased 10-fold to 6.3 x10 15 (a yield of ∼ 17 kJ, which is greater than the energy invested in the DT fuel ∼ 12kJ). At that level, the yield from alpha self-heating is essentially equivalent to the compression yield, indicating that we are close to the alpha self-heating regime. Low adiabat, 4-shock High Density Carbon (HDC) capsules have been imploded in conventional gas-filled hohlraums, and employing a 6 ns, 2-shock pulse, HDC capsules were imploded in near-vacuum hohlraums with overall coupling ∼ 98%. Both the 4- and 2-shock HDC capsules had very low mix and high yield over simulated performance. Rugby holraums have demonstrated uniform x-ray drive with minimal Cross Beam Energy Transfer (CBET), and we have made good progress in measuring and modelling growth of ablation front hydro instabilities. (paper)

RETRIEVING SUSPECT TRANSURANIC WASTE FROM THE HANFORD BURIAL GROUNDS PROGRESS PLANS AND CHALLENGES

International Nuclear Information System (INIS)

FRENCH, M.S.

2006-01-01

This paper describes the scope and status of the program for retrieval of suspect transuranic (TRU) waste stored in the Hanford Site low-level burial grounds. Beginning in 1970 and continuing until the late 1980's, waste suspected of containing significant quantities of transuranic isotopes was placed in ''retrievable'' storage in designated modules in the Hanford burial grounds, with the intent that the waste would be retrieved when a national repository for disposal of such waste became operational. Approximately 15,000 cubic meters of waste, suspected of being TRU, was placed in storage modules in four burial grounds. With the availability of the national repository (the Waste Isolation Pilot Plant), retrieval of the suspect TRU waste is now underway. Retrieval efforts, to date, have been conducted in storage modules that contain waste, which is in general, contact-handled, relatively new (1980's and later), is stacked in neat, engineered configurations, and has a relatively good record of waste characteristics. Even with these optimum conditions, retrieval personnel have had to deal with a large number of structurally degraded containers, radioactive contamination issues, and industrial hazards (including organic vapors). Future retrieval efforts in older, less engineered modules are expected to present additional hazards and difficult challenges

Status Problem and Expectations of Competence: A Challenging Path for Teachers

Science.gov (United States)

Pescarmona, Isabella

2015-01-01

Complex Instruction (CI) is a cooperative learning approach, which aims at improving the equal status interaction among students working in groups who may be at different academic and social levels. Based on an ethnographic research, the article examines how a group of Italian primary school teachers understand the status problem and how the…

Tunneling progress on the Yucca Mountain Project

International Nuclear Information System (INIS)

Hansmire, W.H.; Munzer, R.J.

1996-01-01

The current status of tunneling progress on the Yucca Mountain Project (YMP) is presented in this paper. The Exploratory Studies Facility (ESF), a key part of the YMP, has been long in development and construction is ongoing. This is a progress report on the tunneling aspects of the ESF as of January 1, 1996. For purposes of discussion in this summary, the tunneling has progressed in four general phases. The paper describes: tunneling in jointed rock under low stress; tunneling through the Bow Ridge Fault and soft rock; tunneling through the Imbricate Fault Zone; and Tunneling into the candidate repository formation

Emergency Surgery for Refractory Status Epilepticus.

Science.gov (United States)

Botre, Abhijeet; Udani, Vrajesh; Desai, Neelu; Jagadish, Spoorthy; Sankhe, Milind

2017-08-15

Management of refractory status epilepticus in children is extremely challenging. Two children with medically refractory status epilepticus, both of whom had lesional pathology on MRI and concordant data on EEG and PET scan. Emergency hemispherotomy performed in both patients. A complete, sustained seizure freedom obtained postoperatively. Emergency surgery is a treatment option in selected cases of drug refractory status epilepticus with lesional pathology and concordant data.

Solar lease grant program. Technical progress report

Energy Technology Data Exchange (ETDEWEB)

1981-04-01

Progress on a lease program for the installation of a solar water heater with no installation charge is reported. Information on the announcement of the program, the selection of participants, the contractural agreement, progress on installation of equipment, monitoring, and evaluation is summarized. The status of the budget concerned with the program is announced. Forms used for applications for the program and an announcement from Resource Alternatives for Cilco customers are presented.

Self-reported levels of education and disability progression in multiple sclerosis

NARCIS (Netherlands)

D'hooghe, M. B.; Haentjens, P.; Van Remoortel, A.; De Keyser, J.; Nagels, G.

2016-01-01

ObjectivesThe purpose of our study is to investigate whether socioeconomic indicators such as education, financial concerns, employment, and living status are associated with disease progression in relapsing-onset and progressive-onset Multiple Sclerosis (MS). Materials and methodsWe performed a

Creutzfeldt-Jakob Disease Presenting as Expressive Aphasia and Nonconvulsive Status Epilepticus

Directory of Open Access Journals (Sweden)

Hafiz B. Mahboob

2018-01-01

Full Text Available Creutzfeldt-Jakob disease (CJD, the most common form of human prion diseases, is a fatal condition with a mortality rate reaching 85% within one year of clinical presentation. CJD is characterized by rapidly progressive neurological deterioration in combination with typical electroencephalography (EEG and magnetic resonance imaging (MRI findings and positive cerebrospinal spinal fluid (CSF analysis for 14-3-3 proteins. Unfortunately, CJD can have atypical clinical and radiological presentation in approximately 10% of cases, thus making the diagnosis often challenging. We report a rare clinical presentation of sporadic CJD (sCJD with combination of both expressive aphasia and nonconvulsive status epilepticus. This patient presented with slurred speech, confusion, myoclonus, headaches, and vertigo and succumbed to his disease within ten weeks of initial onset of his symptoms. He had a normal initial diagnostic workup, but subsequent workup initiated due to persistent clinical deterioration revealed CJD with typical MRI, EEG, and CSF findings. Other causes of rapidly progressive dementia and encephalopathy were ruled out. Though a rare condition, we recommend consideration of CJD on patients with expressive aphasia, progressive unexplained neurocognitive decline, and refractory epileptiform activity seen on EEG. Frequent reimaging (MRI, video EEGs and CSF examination might help diagnose this fatal condition earlier.

Recent progress in sodium technology

Energy Technology Data Exchange (ETDEWEB)

Hallett, W. J.

1963-10-15

Progress over the past year in U. S. laboratories studying some of the materials and engineering problems that must be resolved in bringing the technology of sodium to an economically and technically attractive point is reviewed. The status of sodium cooled power reactors in the U. S. is described. (P.C.H.)

Human rights in Japan: progress and challenges

Directory of Open Access Journals (Sweden)

Yolanda Muñoz González

2007-11-01

Full Text Available The aim of this paper is to present an overview of the improvements and challenges that Japan has been facing between 1983 and 2007. The paper explores the interaction among the different stakeholders –i.e. the Japanese Government, international organizations and civil society- to advance full access to citizenship regarding gender equality, the elimination of social and physical barriers for the inclusion of people with disabilities and elderly persons; ethnic minorities –specifically the situation of the Ainu people and the Buraku community – and the persons considered as “foreigners” living in Japan.

The BGO collaboration progress report 1990

International Nuclear Information System (INIS)

Anon.

1990-01-01

A large solid angle BGO calorimeter is under contruction for photo-nuclear experiments at intermediate energy facilities. In this note the status progress of the project, the technical steps undertaken in the construction of the apparatus and the goals of this initiative are reviewed

Topical report review status

International Nuclear Information System (INIS)

1982-08-01

A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

Topical report review status

International Nuclear Information System (INIS)

1983-01-01

A Topical Report Review Status is scheduled to be published semi-annually. The primary purpose of this document is to provide periodic progress reports of on-going topical report reviews, to identify those topical reports for which the Nuclear Regulatory Commission (NRC) staff review has been completed and, to the extent practicable, to provide NRC management with sufficient information regarding the conduct of the topical report program to permit taking whatever actions deemed necessary or appropriate. This document is also intended to be a source of information to NRC Licensing Project Managers and other NRC personnel regarding the status of topical reports which may be referenced in applications for which they have responsibility. This status report is published primarily for internal NRC use in managing the topical report program, but is also used by NRC to advise the industry of report review status

Mountains and energy transition. Status of use of renewable energies and challenges for their development in mountain areas - Renewable energies Volume 1

International Nuclear Information System (INIS)

Peguin, Marion; Moncorps, Sebastien; Fourcade, Michel; Denis, Helene

2013-10-01

After an overview of challenges related to the development of renewable energies in mountain areas (conservation of biodiversity and landscapes, main legal measures regarding biodiversity and landscapes), this report proposes an overview of the status and potentials of the different renewable energies (solar, wind, hydroelectricity, bio-energies, geothermal) in mountain areas. It proposes an assessment (strengths and weaknesses) and recommendations for solar, wind, hydroelectricity and bio energies in mountain areas

Stable isotope views on ecosystem function: challenging or challenged?

Science.gov (United States)

Resco, Víctor; Querejeta, José I.; Ogle, Kiona; Voltas, Jordi; Sebastià, Maria-Teresa; Serrano-Ortiz, Penélope; Linares, Juan C.; Moreno-Gutiérrez, Cristina; Herrero, Asier; Carreira, José A.; Torres-Cañabate, Patricia; Valladares, Fernando

2010-01-01

Stable isotopes and their potential for detecting various and complex ecosystem processes are attracting an increasing number of scientists. Progress is challenging, particularly under global change scenarios, but some established views have been challenged. The IX meeting of the Spanish Association of Terrestrial Ecology (AAET, Úbeda, 18–22 October 2009) hosted a symposium on the ecology of stable isotopes where the linear mixing model approach of partitioning sinks and sources of carbon and water fluxes within an ecosystem was challenged, and new applications of stable isotopes for the study of plant interactions were evaluated. Discussion was also centred on the need for networks that monitor ecological processes using stable isotopes and key ideas for fostering future research with isotopes. PMID:20015858

Hazardous and toxic waste management in Botswana: practices and challenges.

Science.gov (United States)

Mmereki, Daniel; Li, Baizhan; Meng, Liu

2014-12-01

Hazardous and toxic waste is a complex waste category because of its inherent chemical and physical characteristics. It demands for environmentally sound technologies and know-how as well as clean technologies that simultaneously manage and dispose it in an environmentally friendly way. Nevertheless, Botswana lacks a system covering all the critical steps from importation to final disposal or processing of hazardous and toxic waste owing to limited follow-up of the sources and types of hazardous and toxic waste, lack of modern and specialised treatment/disposal facilities, technical know-how, technically skilled manpower, funds and capabilities of local institutions to take lead in waste management. Therefore, because of a lack of an integrated system, there are challenges such as lack of cooperation among all the stakeholders about the safe management of hazardous and toxic waste. Furthermore, Botswana does not have a systematic regulatory framework regarding monitoring and hazardous and toxic waste management. In addition to the absence of a systematic regulatory framework, inadequate public awareness and dissemination of information about hazardous and toxic waste management, slower progress to phase-out persistent and bio-accumulative waste, and lack of reliable and accurate information on hazardous and toxic waste generation, sources and composition have caused critical challenges to effective hazardous and toxic waste management. It is, therefore, important to examine the status of hazardous and toxic waste as a waste stream in Botswana. By default; this mini-review article presents an overview of the current status of hazardous and toxic waste management and introduces the main challenges in hazardous and toxic waste management. Moreover, the article proposes the best applicable strategies to achieve effective hazardous and toxic waste management in the future. © The Author(s) 2014.

Status Epilepticus and Beyond: A Clinical Review of Status Epilepticus and an Update on Current Management Strategies in Super-refractory Status Epilepticus

Directory of Open Access Journals (Sweden)

Roy Poblete

2017-05-01

Full Text Available Status epilepticus and refractory status epilepticus represent some of the most complex conditions encountered in the neurological intensive care unit. Challenges in management are common as treatment options become limited and prolonged hospital courses are accompanied by complications and worsening patient outcomes. Antiepileptic drug treatments have become increasingly complex. Rational polytherapy should consider the pharmacodynamics and kinetics of medications. When seizures cannot be controlled with medical therapy, alternative treatments, including early surgical evaluation can be considered; however, evidence is limited. This review provides a brief overview of status epilepticus, and a recent update on the management of refractory status epilepticus based on evidence from the literature, evidence-based guidelines, and experiences at our institution.

Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS.

Science.gov (United States)

Fox, Robert J; Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

2012-11-01

Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS.

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

Science.gov (United States)

Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

2012-01-01

Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS. PMID:22917690

Accreditation status of hospital pharmacies and their challenges of medication management: A case of south Iranian largest university.

Science.gov (United States)

Barati, Omid; Dorosti, Hesam; Talebzadeh, Alireza; Bastani, Peivand

2016-01-01

Considering the importance of accreditation for hospital pharmacies, this study was to determine the challenges of medication management in hospital pharmacies affiliated with Shiraz University of Medical Sciences, Iran. The study was a mix-method research conducted in two qualitative and quantitative phases during the years 2014-2015 in Shiraz, Iran. National Accreditation Standard checklist for hospitals was used for data collection in the first phase, and Delphi method was applied in three rounds to achieve the most challenges of medication management and the related solutions. Results indicated a medium status of accreditation for all three dimensions in the above hospital pharmacies (3.53, 42.15 and 7, respectively). Lack of clinical pharmacists, nonparticipation of the pharmacy director in annual budgeting, lack of access to patient information, discontinuity of pharmaceutical care for patients discharged, defects in pharmacy staff training, lack of legislation in support of pharmacists and lack of adequate access to physicians' prescriptions, shortages in reporting medication errors, and lack of evidence related to microbial contamination are the most challenges extracted from the second phase. It seems that the studied hospital pharmacies encounter numerous problems regarding accreditation, pharmaceutical care as well as appropriate medication management and supply chain. Attempts to solve these problems can play an important role in improving the efficiency and effectiveness of pharmacies in Iran.

Accreditation status of hospital pharmacies and their challenges of medication management: A case of south Iranian largest university

Directory of Open Access Journals (Sweden)

Omid Barati

2016-01-01

Full Text Available Considering the importance of accreditation for hospital pharmacies, this study was to determine the challenges of medication management in hospital pharmacies affiliated with Shiraz University of Medical Sciences, Iran. The study was a mix-method research conducted in two qualitative and quantitative phases during the years 2014–2015 in Shiraz, Iran. National Accreditation Standard checklist for hospitals was used for data collection in the first phase, and Delphi method was applied in three rounds to achieve the most challenges of medication management and the related solutions. Results indicated a medium status of accreditation for all three dimensions in the above hospital pharmacies (3.53, 42.15 and 7, respectively. Lack of clinical pharmacists, nonparticipation of the pharmacy director in annual budgeting, lack of access to patient information, discontinuity of pharmaceutical care for patients discharged, defects in pharmacy staff training, lack of legislation in support of pharmacists and lack of adequate access to physicians' prescriptions, shortages in reporting medication errors, and lack of evidence related to microbial contamination are the most challenges extracted from the second phase. It seems that the studied hospital pharmacies encounter numerous problems regarding accreditation, pharmaceutical care as well as appropriate medication management and supply chain. Attempts to solve these problems can play an important role in improving the efficiency and effectiveness of pharmacies in Iran.

Tracking progress towards equitable child survival in a Nicaraguan community: neonatal mortality challenges to meet the MDG 4

Directory of Open Access Journals (Sweden)

Persson Lars-Åke

2011-06-01

Full Text Available Abstract Background Nicaragua has made progress in the reduction of the under-five mortality since 1980s. Data for the national trends indicate that this poor Central American country is on track to reach the Millennium Development Goal-4 by 2015. Despite this progress, neonatal mortality has not showed same progress. The aim of this study is to analyse trends and social differentials in neonatal and under-five mortality in a Nicaraguan community from 1970 to 2005. Methods Two linked community-based reproductive surveys in 1993 and 2002 followed by a health and demographic surveillance system providing information on all births and child deaths in urban and rural areas of León municipality, Nicaragua. A total of 49 972 live births were registered. Results A rapid reduction in under-five mortality was observed during the late 1970s (from 103 deaths/1000 live births and the 1980s, followed by a gradual decline to the level of 23 deaths/1000 live births in 2005. This community is on track for the Millennium Development Goal 4 for improved child survival. However, neonatal mortality increased lately in spite of a good coverage of skilled assistance at delivery. After some years in the 1990s with a very small gap in neonatal survival between children of mothers of different educational levels this divide is increasing. Conclusions After the reduction of high under-five mortality that coincided with improved equity in survival in this Nicaraguan community, the current challenge is the neonatal mortality where questions of an equitable perinatal care of good quality must be addressed.

Workplace Charging Challenge Mid-Program Review: Employees Plug In

Energy Technology Data Exchange (ETDEWEB)

None, None

2015-12-31

The EV Everywhere Workplace Charging Challenge aims to have 500 U.S. employers offering workplace charging by 2018. These reports describe the progress made in the Challenge. In 2015, the Workplace Charging Challenge celebrated a major milestone – it reached the halfway point to its goal of 500 Challenge partners committed to installing workplace charging by 2018. More than 250 employers have joined as Challenge partners and the installation of workplace charging as a sustainable business practice is growing across the country. Their efforts have resulted in more than 600 workplaces with over 5,500 charging stations accessible to nearly one million employees. In 2015, more than 9,000 PEV-driving employees charged at these worksites on a regular basis. Our Workplace Charging Challenge Mid-Program Review reports this progress and other statistics related to workplace charging, including employee satisfaction and charger usage.

Clinical decision making in seizures and status epilepticus.

Science.gov (United States)

Teran, Felipe; Harper-Kirksey, Katrina; Jagoda, Andy

2015-01-01

Seizures and status epilepticus are frequent neurologic emergencies in the emergency department, accounting for 1% of all emergency department visits. The management of this time-sensitive and potentially life-threatening condition is challenging for both prehospital providers and emergency clinicians. The approach to seizing patients begins with differentiating seizure activity from mimics and follows with identifying potential secondary etiologies, such as alcohol-related seizures. The approach to the patient in status epilepticus and the patient with nonconvulsive status epilepticus constitutes a special clinical challenge. This review summarizes the best available evidence and recommendations regarding diagnosis and resuscitation of the seizing patient in the emergency setting.

Material challenges for solar cells in the twenty-first century: directions in emerging technologies.

Science.gov (United States)

Almosni, Samy; Delamarre, Amaury; Jehl, Zacharie; Suchet, Daniel; Cojocaru, Ludmila; Giteau, Maxime; Behaghel, Benoit; Julian, Anatole; Ibrahim, Camille; Tatry, Léa; Wang, Haibin; Kubo, Takaya; Uchida, Satoshi; Segawa, Hiroshi; Miyashita, Naoya; Tamaki, Ryo; Shoji, Yasushi; Yoshida, Katsuhisa; Ahsan, Nazmul; Watanabe, Kentaro; Inoue, Tomoyuki; Sugiyama, Masakazu; Nakano, Yoshiaki; Hamamura, Tomofumi; Toupance, Thierry; Olivier, Céline; Chambon, Sylvain; Vignau, Laurence; Geffroy, Camille; Cloutet, Eric; Hadziioannou, Georges; Cavassilas, Nicolas; Rale, Pierre; Cattoni, Andrea; Collin, Stéphane; Gibelli, François; Paire, Myriam; Lombez, Laurent; Aureau, Damien; Bouttemy, Muriel; Etcheberry, Arnaud; Okada, Yoshitaka; Guillemoles, Jean-François

2018-01-01

Photovoltaic generation has stepped up within the last decade from outsider status to one of the important contributors of the ongoing energy transition, with about 1.7% of world electricity provided by solar cells. Progress in materials and production processes has played an important part in this development. Yet, there are many challenges before photovoltaics could provide clean, abundant, and cheap energy. Here, we review this research direction, with a focus on the results obtained within a Japan-French cooperation program, NextPV, working on promising solar cell technologies. The cooperation was focused on efficient photovoltaic devices, such as multijunction, ultrathin, intermediate band, and hot-carrier solar cells, and on printable solar cell materials such as colloidal quantum dots.

Enamel Regeneration - Current Progress and Challenges

Science.gov (United States)

Baswaraj; H.K, Navin; K.B, Prasanna

2014-01-01

Dental Enamel is the outermost covering of teeth. It is hardest mineralized tissue present in the human body. Enamel faces the challenge of maintaining its integrity in a constant demineralization and remineralization within the oral environment and it is vulnerable to wear, damage, and decay. It cannot regenerate itself, because it is formed by a layer of cells that are lost after the tooth eruption. Conventional treatment relies on synthetic materials to restore lost enamel that cannot mimic natural enamel. With advances in material science and understanding of basic principles of organic matrix mediated mineralization paves a way for formation of synthetic enamel. The knowledge of enamel formation and understanding of protein interactions and their gene products function along with the isolation of postnatal stem cells from various sources in the oral cavity, and the development of smart materials for cell and growth factor delivery, makes possibility for biological based enamel regeneration. This article will review the recent endeavor on biomimetic synthesis and cell based strategies for enamel regeneration. PMID:25386548

Buff book 1: status summary report, water reactor safety research

International Nuclear Information System (INIS)

1980-01-01

This Management Report, to provide information for monitoring and controlling the progress of LWR Safety Research Projects Associated with the Office of Nuclear Regulatory Research and other agencies and organizations engaged in nuclear safety research. It utilizes data pertaining to project schedules, cost, and status which have been integrated into a network-based management information system, The purpose of this publication is to provide a vehicle for review of the current status and overall progress of the safety Research Program from a managerial point of view

Biogas Opportunities Roadmap Progress Report

Energy Technology Data Exchange (ETDEWEB)

None, None

2015-12-01

In support of the Obama Administration's Climate Action Plan, the U.S. Department of Energy, the U.S. Environmental Protection Agency, and U.S. Department of Agriculture jointly released the Biogas Opportunities Roadmap Progress Report, updating the federal government's progress to reduce methane emissions through biogas systems since the Biogas Opportunities Roadmap was completed by the three agencies in July 2014. The report highlights actions taken, outlines challenges and opportunities, and identifies next steps to the growth of a robust biogas industry.

Interactions between biomass-burning aerosols and clouds over Southeast Asia: current status, challenges, and perspectives.

Science.gov (United States)

Lin, Neng-Huei; Sayer, Andrew M; Wang, Sheng-Hsiang; Loftus, Adrian M; Hsiao, Ta-Chih; Sheu, Guey-Rong; Hsu, N Christina; Tsay, Si-Chee; Chantara, Somporn

2014-12-01

The interactions between aerosols, clouds, and precipitation remain among the largest sources of uncertainty in the Earth's energy budget. Biomass-burning aerosols are a key feature of the global aerosol system, with significant annually-repeating fires in several parts of the world, including Southeast Asia (SEA). SEA in particular provides a "natural laboratory" for these studies, as smoke travels from source regions downwind in which it is coupled to persistent stratocumulus decks. However, SEA has been under-exploited for these studies. This review summarizes previous related field campaigns in SEA, with a focus on the ongoing Seven South East Asian Studies (7-SEAS) and results from the most recent BASELInE deployment. Progress from remote sensing and modeling studies, along with the challenges faced for these studies, are also discussed. We suggest that improvements to our knowledge of these aerosol/cloud effects require the synergistic use of field measurements with remote sensing and modeling tools. Copyright © 2014 Elsevier Ltd. All rights reserved.

Using Cogenerative Dialogs to Improve Science Teaching and Learning: Challenges and Solutions in High School Students' Internships

Science.gov (United States)

Hsu, Pei-Ling

2018-05-01

Internships in science research settings have received increasing attention as a means of helping students construct appropriate understandings, practices, tools, and language in scientific activities. To advance student-scientist partnerships beyond the status quo, the study aimed to investigate how cogenerative dialogs (cogens) may help high school students and scientists identify and address challenges collectively. The analysis identified nine major challenges discussed during cogens: (1) the quality and progress of scientific practice in laboratories, (2) the quality of scientists'/assistants' instructions in classrooms, (3) the quality of student participation in classrooms and homework, (4) students' absences, including arriving late or leaving early, (5) the quality of administrative support, (6) preparation for scientific presentations, (7) the process of deciding project topics, (8) students' peer interactions and communication, and (9) students' physiological needs. The three most salient challenges were "the quality and progress of scientific practice in laboratories" (39%), "the quality of scientists'/assistants' instructions in classrooms" (20%), and "the quality of student participation in classrooms and homework" (17%). The study shows that cogens allowed students and scientists to agree on teaching modifications that positively influenced teaching and learning processes during the internship, such that issues were reduced from the beginning to the closing stages. Importantly, the challenges and solutions identified by students and scientists in this study provide accounts of first-hand experience as well as insights to aid program directors or coordinators in designing a learning environment that can foster effective practice for internships by avoiding the issues identified in the study.

Progress of the HTR-10 project

International Nuclear Information System (INIS)

Zhong, D.; Xu, Y.

1996-01-01

This paper briefly introduces the main technical features and the design specifications of the HTR-10. Present status and main progress of the license applications, the design and manufacture of the main components and the engineering experiments as well as the construction of the HTR-10 are summarized. (author). 3 tabs

Prevalence of Sarcopenia and Its Association with Socioeconomic Status among the Elderly in Tehran.

Science.gov (United States)

Dorosty, Ahmadreza; Arero, Godana; Chamar, Maryam; Tavakoli, Sogand

2016-07-01

Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. It imposes significant costs on health care systems. Socioeconomic status is also the root cause of healthy challenges among the elderly. Therefore, investigating the association between sarcopenia and socioeconomic status is very important to improve healthy ageing of the elderly. The aim of this study was to investigate the prevalence of sarcopenia and its association with socioeconomic status among the elderly in Tehran. Cross-sectional and case-control studies were conducted from August 2014-July 2015 among 310 men and 334 women elderly (60 and over years old) in Tehran health centers. Randomization, restriction and matching were setting during study design to minimize selection bias. Then study participants were recruited via phone call. Participants' phone numbers were already recorded in a telephone book electronically. When there were two elderly people in the same house, only one person was invited randomly. Association between sarcopenia and socio-economic status was analyzed by SPSS version 22. The overall prevalence of sarcopenia in the elderly was 16.5%. Prevalenceamong the low-income elderly was relatively higher than (20.5%) that among those with middle income status (18.2%) while in the higher income, the proportion of sarcopenia was very low (12.8%). The findings indicated that 339(52.6%) were in low-income status, 304(47.1%) were in middle-income status and 1(.2%) in high-income class. There was a significant association between socioeconomic status and sarcopenia (P-value sarcopenia was 0.97 times more likely higher in low socioeconomic class than those who were in middle and high income classes.

Monte Carlos of the new generation: status and progress

International Nuclear Information System (INIS)

Frixione, Stefano

2005-01-01

Standard parton shower monte carlos are designed to give reliable descriptions of low-pT physics. In the very high-energy regime of modern colliders, this is may lead to largely incorrect predictions of the basic reaction processes. This motivated the recent theoretical efforts aimed at improving monte carlos through the inclusion of matrix elements computed beyond the leading order in QCD. I briefly review the progress made, and discuss bottom production at the Tevatron

Philanthropy and disparities: progress, challenges, and unfinished business.

Science.gov (United States)

Mitchell, Faith; Sessions, Kathryn

2011-10-01

Philanthropy has invested millions of dollars to reduce disparities in health care and improve minority health. Grants to strengthen providers' cultural competence, diversify health professions, and collect data have improved understanding of and spurred action on disparities. The persistence of disparities in spite of these advances has shifted philanthropic attention toward strategies to change social, economic, and environmental conditions. We argue that these evolving perspectives, along with earlier groundwork, present new opportunities for funders, especially in combination with progress toward universal health coverage. This article looks at how philanthropy has addressed health disparities over the past decade, with a focus on accomplishments, the work remaining to be done, and how funders can help advance the disparities agenda.

Maternal and child health in Brazil: progress and challenges.

Science.gov (United States)

Victora, Cesar G; Aquino, Estela M L; do Carmo Leal, Maria; Monteiro, Carlos Augusto; Barros, Fernando C; Szwarcwald, Celia L

2011-05-28

In the past three decades, Brazil has undergone rapid changes in major social determinants of health and in the organisation of health services. In this report, we examine how these changes have affected indicators of maternal health, child health, and child nutrition. We use data from vital statistics, population censuses, demographic and health surveys, and published reports. In the past three decades, infant mortality rates have reduced substantially, decreasing by 5·5% a year in the 1980s and 1990s, and by 4·4% a year since 2000 to reach 20 deaths per 1000 livebirths in 2008. Neonatal deaths account for 68% of infant deaths. Stunting prevalence among children younger than 5 years decreased from 37% in 1974-75 to 7% in 2006-07. Regional differences in stunting and child mortality also decreased. Access to most maternal-health and child-health interventions increased sharply to almost universal coverage, and regional and socioeconomic inequalities in access to such interventions were notably reduced. The median duration of breastfeeding increased from 2·5 months in the 1970s to 14 months by 2006-07. Official statistics show stable maternal mortality ratios during the past 10 years, but modelled data indicate a yearly decrease of 4%, a trend which might not have been noticeable in official reports because of improvements in death registration and the increased number of investigations into deaths of women of reproductive age. The reasons behind Brazil's progress include: socioeconomic and demographic changes (economic growth, reduction in income disparities between the poorest and wealthiest populations, urbanisation, improved education of women, and decreased fertility rates), interventions outside the health sector (a conditional cash transfer programme and improvements in water and sanitation), vertical health programmes in the 1980s (promotion of breastfeeding, oral rehydration, and immunisations), creation of a tax-funded national health service in 1988

Current situation and challenge of registry in China.

Science.gov (United States)

Zhang, Yang; Feng, Yuji; Qu, Zhi; Qi, Yali; Zhan, Siyan

2014-09-01

Increasing emphasis has been placed on registries for an organized system used in developing clinical research to improve health care. China has sufficient data that can be applied broadly, but the heterogeneity and irregularity of registries limit their applicability. This article aims to describe the status of registries in China and the related challenges. Patient registries for observational studies were retrieved from the International Clinical Trials Registry to quantitatively evaluate the number of comparatively high-quality registries in China. A literature search was also performed to provide support and updates. A total of 64 patient registries were retrieved from ClinicalTrials.gov using disease, product, and health service as criteria. The sample sizes ranged from 15 to 30,400, with only 12 registries marked as completed. This article describes and compares the detailed information in many aspects. The efficient use of registries has already made considerable progress in China; however, registries still require standardization, high-quality transition, and coordinated development.

Chondrichthyan Diversity, Conservation Status, and Management Challenges in Costa Rica

Directory of Open Access Journals (Sweden)

Mario Espinoza

2018-03-01

Full Text Available Understanding key aspects of the biology and ecology of chondrichthyan fishes (sharks, rays, and chimeras, as well as the range of threats affecting their populations is crucial given the rapid rate at which some species are declining. In the Eastern Tropical Pacific (ETP, the lack of knowledge, unreliable (or non-existent landing statistics, and limited enforcement of existing fisheries regulations has hindered management and conservation efforts for chondrichthyan species. This review evaluated our current understanding of Costa Rican chondrichthyans and their conservation status. Specifically, we (1 provide an updated checklist on the species richness, habitat use, and distribution patterns, (2 summarize the most relevant chondrichthyan studies (scientific publications, theses, and official technical reports, (3 identify knowledge gaps, (4 discuss fisheries-related threats, and (5 highlight the management challenges and research needs to effectively protect their populations. A total of 99 chondrichthyan species are formally recorded in Costa Rican waters, from which 15% are threatened with extinction and 41% are “Data Deficient” based on the IUCN (International Union for Conservation of Nature Red List. A total of 121 studies were published between 1891 and 2017; 82% in the Pacific (24% from Isla del Coco and only 18% from the Caribbean Sea. These results highlight the need to redirect research efforts on specific taxonomic groups and geographic regions (i.e., Caribbean. Based on our review, improving the quality and quantity of fisheries landing statistics, as well as determining the degree of overlap between chondrichthyans and Costa Rican fisheries remains a priority. We proposed an adaptive management framework for chondrichthyan fisheries in data-poor countries where management goals/targets are clearly defined. This framework could strengthen the conservation of chondrichthyan populations in Costa Rica and the region.

Refractory status epilepticus

Directory of Open Access Journals (Sweden)

Sanjay P Singh

2014-01-01

Full Text Available Refractory status epilepticus is a potentially life-threatening medical emergency. It requires early diagnosis and treatment. There is a lack of consensus upon its semantic definition of whether it is status epilepticus that continues despite treatment with benzodiazepine and one antiepileptic medication (AED, i.e., Lorazepam + phenytoin. Others regard refractory status epilepticus as failure of benzodiazepine and 2 antiepileptic medications, i.e., Lorazepam + phenytoin + phenobarb. Up to 30% patients in SE fail to respond to two antiepileptic drugs (AEDs and 15% continue to have seizure activity despite use of three drugs. Mechanisms that have made the treatment even more challenging are GABA-R that is internalized during status epilepticus and upregulation of multidrug transporter proteins. All patients of refractory status epilepticus require continuous EEG monitoring. There are three main agents used in the treatment of RSE. These include pentobarbital or thiopental, midazolam and propofol. RSE was shown to result in mortality in 35% cases, 39.13% of patients were left with severe neurological deficits, while another 13% had mild neurological deficits.

Refractory status epilepticus

Science.gov (United States)

Singh, Sanjay P; Agarwal, Shubhi; Faulkner, M

2014-01-01

Refractory status epilepticus is a potentially life-threatening medical emergency. It requires early diagnosis and treatment. There is a lack of consensus upon its semantic definition of whether it is status epilepticus that continues despite treatment with benzodiazepine and one antiepileptic medication (AED), i.e., Lorazepam + phenytoin. Others regard refractory status epilepticus as failure of benzodiazepine and 2 antiepileptic medications, i.e., Lorazepam + phenytoin + phenobarb. Up to 30% patients in SE fail to respond to two antiepileptic drugs (AEDs) and 15% continue to have seizure activity despite use of three drugs. Mechanisms that have made the treatment even more challenging are GABA-R that is internalized during status epilepticus and upregulation of multidrug transporter proteins. All patients of refractory status epilepticus require continuous EEG monitoring. There are three main agents used in the treatment of RSE. These include pentobarbital or thiopental, midazolam and propofol. RSE was shown to result in mortality in 35% cases, 39.13% of patients were left with severe neurological deficits, while another 13% had mild neurological deficits. PMID:24791086

Wearable sensors: modalities, challenges, and prospects.

Science.gov (United States)

Heikenfeld, J; Jajack, A; Rogers, J; Gutruf, P; Tian, L; Pan, T; Li, R; Khine, M; Kim, J; Wang, J; Kim, J

2018-01-16

Wearable sensors have recently seen a large increase in both research and commercialization. However, success in wearable sensors has been a mix of both progress and setbacks. Most of commercial progress has been in smart adaptation of existing mechanical, electrical and optical methods of measuring the body. This adaptation has involved innovations in how to miniaturize sensing technologies, how to make them conformal and flexible, and in the development of companion software that increases the value of the measured data. However, chemical sensing modalities have experienced greater challenges in commercial adoption, especially for non-invasive chemical sensors. There have also been significant challenges in making significant fundamental improvements to existing mechanical, electrical, and optical sensing modalities, especially in improving their specificity of detection. Many of these challenges can be understood by appreciating the body's surface (skin) as more of an information barrier than as an information source. With a deeper understanding of the fundamental challenges faced for wearable sensors and of the state-of-the-art for wearable sensor technology, the roadmap becomes clearer for creating the next generation of innovations and breakthroughs.

ISABELLE: a progress report

Energy Technology Data Exchange (ETDEWEB)

Hahn, H

1980-01-01

This paper discusses the ISABELLE project, which has the objective of constructing a high-energy proton colliding beam facility at Brookhaven National Laboratory. The major technical features of the intersecting storage accelerators with their projected performance are described. Application of over 1000 superconducting magnets in the two rings represents the salient characteristic of the machine. The status of the entire project, the technical progress made so far, and difficulties encountered are reviewed.

Clean Energy Progress Report

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

For the past several years, the IEA and others have been calling for a clean energy revolution to achieve global energy security, economic growth and climate change goals. This report analyses for the first time progress in global clean energy technology deployment against the pathways that are needed to achieve these goals. It provides an overview of technology deployment status, key policy developments and public spending on RDD&D of clean energy technologies.

ISABELLE: a progress report

International Nuclear Information System (INIS)

Hahn, H.

1980-01-01

This paper discusses the ISABELLE project, which has the objective of constructing a high-energy proton colliding beam facility at Brookhaven National Laboratory. The major technical features of the intersecting storage accelerators with their projected performance are described. Application of over 1000 superconducting magnets in the two rings represents the salient characteristic of the machine. The status of the entire project, the technical progress made so far, and difficulties encountered are reviewed

The Artificial Leaf: Recent Progress and Remaining Challenges

Directory of Open Access Journals (Sweden)

Mark D Symes

2016-12-01

Full Text Available The prospect of a device that uses solar energy to split water into H2 and O2 is highly attractive in terms of producing hydrogen as a carbon-neutral fuel. In this mini review, key research milestones that have been reached in this field over the last two decades will be discussed, with special focus on devices that use earth-abundant materials. Finally, the remaining challenges in the development of such “artificial leaves” will be highlighted.

Challenges experienced by South Africa in attaining Millennium Development Goals 4, 5 and 6

Directory of Open Access Journals (Sweden)

Fhumulani M. Mulaudzi

2016-05-01

Full Text Available Background: Despite progress made by other countries worldwide in achieving Millennium Development Goals (MDGs 4, 5 and 6, South Africa is experiencing a challenge in attaining positive outcomes for these goals. Objective and setting: To describe the challenges experienced by South Africa regarding the successful implementation of MDGs 4, 5 and 6. Methods: An integrative literature review was used to identify and synthesise various streams of literature on the challenges experienced by South Africa in attaining MDGs 4, 5 and 6. Results: The integrative review revealed the following themes: (1 interventions related to child mortality reduction, (2 implementation of maternal mortality reduction strategies, and (3 identified barriers to zero HIV and TB infections and management. Conclusion: It is recommended that poverty relief mechanisms be intensified to improve the socio-economic status of women. There is a need for sectoral planning towards maternal health, and training of healthcare workers should emphasise the reduction of maternal deaths. Programmes addressing the reduction of maternal and child mortality rates, HIV, STIs and TB need to be put in place. Keywords: Millennium Development Goals; maternal and child morbidity and mortality; HIV and AIDS; STI and TB

Safety analysis - current and future regulatory challenges

Energy Technology Data Exchange (ETDEWEB)

Jamieson, T., E-mail: Terry.Jamieson@cnsc-ccsn.gc.ca [Canadian Nuclear Safety Commission, Ottawa, ON (Canada)

2015-07-01

'Full text:' The current and future regulatory challenges associated with deterministic safety analysis are reviewed, including: 1. The CNSC's and safety control areas. 2. Traditional safety analysis approach. 3. Experience gained and impact. 4. Current analysis and regulatory approaches. 5. Current status. 6. Complexity and challenges In particular, the technical, regulatory and strategic aspects of these challenges are discussed. (author)

Safety analysis - current and future regulatory challenges

International Nuclear Information System (INIS)

Jamieson, T.

2015-01-01

'Full text:' The current and future regulatory challenges associated with deterministic safety analysis are reviewed, including: 1. The CNSC's and safety control areas. 2. Traditional safety analysis approach. 3. Experience gained and impact. 4. Current analysis and regulatory approaches. 5. Current status. 6. Complexity and challenges In particular, the technical, regulatory and strategic aspects of these challenges are discussed. (author)

Fuel Cell Buses in U.S. Transit Fleets: Current Status 2017

Energy Technology Data Exchange (ETDEWEB)

Eudy, Leslie [National Renewable Energy Lab. (NREL), Golden, CO (United States); Post, Matthew B [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2017-11-21

This report, published annually, summarizes the progress of fuel cell electric bus (FCEB) development in the United States and discusses the achievements and challenges of introducing fuel cell propulsion in transit. The report provides a summary of results from evaluations performed by the National Renewable Energy Laboratory. This annual status report combines results from all FCEB demonstrations, tracks the progress of the FCEB industry toward meeting technical targets, documents the lessons learned, and discusses the path forward for commercial viability of fuel cell technology for transit buses. These data and analyses help provide needed information to guide future early-stage research and development. The 2017 summary results primarily focus on the most recent year for each demonstration, from August 2016 through July 2017. The primary results presented in the report are from five demonstrations of two different fuel-cell-dominant bus designs: Zero Emission Bay Area Demonstration Group led by Alameda-Contra Costa Transit District (AC Transit) in California; American Fuel Cell Bus (AFCB) Project at SunLine Transit Agency in California; AFCB Project at the University of California at Irvine; AFCB Project at Orange County Transportation Authority; and AFCB Project at Massachusetts Bay Transportation Authority.

Orbital Cellulitis: Clinical Course and Management Challenges. The ...

African Journals Online (AJOL)

Orbital Cellulitis: Clinical Course and Management Challenges. The Lagos State University Teaching Hospital Experience. ... The major management challenges were poor financial status of patients precluding necessary diagnostic laboratory and imaging studies. Early recognition, diagnosis and treatment are crucial to ...

Infectious pleural effusion status and treatment progress

Science.gov (United States)

Yang, Wei; Zhang, Ze-Ming

2017-01-01

Pleural cavity infection continuously seriously threatens human health with continuous medical progress. From the perspective of pathophysiology, it can be divided into three stages: exudative stage, fibrin exudation and pus formation stage, and organization stage. Due to the pathogenic bacteria difference of pleural cavity infection and pulmonary infection, it is very important for disease treatment to analyze the bacteria and biochemical characteristics of the infectious pleural effusion. Most prognoses of patients have been relatively good, while for some patients, the complicated parapneumonic effusion or empyema could be evolved. Antibiotic treatment and sufficient drainage are the foundation for this treatment. No evidence can support the routine use of a fibrin agent. However, it has been reported that the plasminogen activator and deoxyribonuclease can be recommended to be applied in the pleural cavity. In case of failure on conservative medical treatment, operative treatment can be applied such as thoracoscopy and pleural decortication. According to the clinical characteristics of these patients, it is a key to research prognosis, as well as early evaluation and stratification, in the future. PMID:29268539

Progress and challenges in the computational prediction of gene function using networks [v1; ref status: indexed, http://f1000r.es/SqmJUM

Directory of Open Access Journals (Sweden)

Paul Pavlidis

2012-09-01

Full Text Available In this opinion piece, we attempt to unify recent arguments we have made that serious confounds affect the use of network data to predict and characterize gene function. The development of computational approaches to determine gene function is a major strand of computational genomics research. However, progress beyond using BLAST to transfer annotations has been surprisingly slow. We have previously argued that a large part of the reported success in using "guilt by association" in network data is due to the tendency of methods to simply assign new functions to already well-annotated genes. While such predictions will tend to be correct, they are generic; it is true, but not very helpful, that a gene with many functions is more likely to have any function. We have also presented evidence that much of the remaining performance in cross-validation cannot be usefully generalized to new predictions, making progressive improvement in analysis difficult to engineer. Here we summarize our findings about how these problems will affect network analysis, discuss some ongoing responses within the field to these issues, and consolidate some recommendations and speculation, which we hope will modestly increase the reliability and specificity of gene function prediction.

Hypothermia for Neuroprotection in Convulsive Status Epilepticus.

Science.gov (United States)

Legriel, Stephane; Lemiale, Virginie; Schenck, Maleka; Chelly, Jonathan; Laurent, Virginie; Daviaud, Fabrice; Srairi, Mohamed; Hamdi, Aicha; Geri, Guillaume; Rossignol, Thomas; Hilly-Ginoux, Julia; Boisramé-Helms, Julie; Louart, Benjamin; Malissin, Isabelle; Mongardon, Nicolas; Planquette, Benjamin; Thirion, Marina; Merceron, Sybille; Canet, Emmanuel; Pico, Fernando; Tran-Dinh, Yves-Roger; Bedos, Jean-Pierre; Azoulay, Elie; Resche-Rigon, Matthieu; Cariou, Alain

2016-12-22

Convulsive status epilepticus often results in permanent neurologic impairment. We evaluated the effect of induced hypothermia on neurologic outcomes in patients with convulsive status epilepticus. In a multicenter trial, we randomly assigned 270 critically ill patients with convulsive status epilepticus who were receiving mechanical ventilation to hypothermia (32 to 34°C for 24 hours) in addition to standard care or to standard care alone; 268 patients were included in the analysis. The primary outcome was a good functional outcome at 90 days, defined as a Glasgow Outcome Scale (GOS) score of 5 (range, 1 to 5, with 1 representing death and 5 representing no or minimal neurologic deficit). The main secondary outcomes were mortality at 90 days, progression to electroencephalographically (EEG) confirmed status epilepticus, refractory status epilepticus on day 1, "super-refractory" status epilepticus (resistant to general anesthesia), and functional sequelae on day 90. A GOS score of 5 occurred in 67 of 138 patients (49%) in the hypothermia group and in 56 of 130 (43%) in the control group (adjusted common odds ratio, 1.22; 95% confidence interval [CI], 0.75 to 1.99; P=0.43). The rate of progression to EEG-confirmed status epilepticus on the first day was lower in the hypothermia group than in the control group (11% vs. 22%; odds ratio, 0.40; 95% CI, 0.20 to 0.79; P=0.009), but there were no significant differences between groups in the other secondary outcomes. Adverse events were more frequent in the hypothermia group than in the control group. In this trial, induced hypothermia added to standard care was not associated with significantly better 90-day outcomes than standard care alone in patients with convulsive status epilepticus. (Funded by the French Ministry of Health; HYBERNATUS ClinicalTrials.gov number, NCT01359332 .).

Women in Arab countries: challenging the patriarchal system?

Science.gov (United States)

Fargues, Philippe

2005-05-01

Progress in the empowerment of Arab women was found to be low in a 2002 report. Yet Arab women's status is not reflected in continuing high fertility, which in 2000 had dropped sharply in one generation to 3.4. This paper discusses why fertility decline could nevertheless have taken place in the Arab countries. Islam has not stood in the way of fertility decline, as Iran and Algeria show. From the mid- 1970s to 1980s, subsidised consumption through oil wealth redistribution reduced the cost of children, and social conservatism kept married women out of the labour force, both of which promoted higher fertility. The early stages of fertility decline were mainly due to longer length of education of girls, rising female age at first marriage, e.g. 28 in urban Morocco and 29 in Libya, and entry into the labour force of young, single women. There is also a growing population sub-group of never-married young women. Collapsing oil prices and structural adjustment reduced household resources and became an effective fertility regulation factor. Girls born since the 1950s have not only been educated longer than their mothers, but also their fathers, which increases their authority. These factors, and women's activism and civil and political lobbying for the reform of personal status now underway in a number of Arab countries, could all challenge the patriarchal system.

Influence of combined therapy with prospidin and methotrexate on radiological progression, functional status and quality of life in pts with rheumatoid arthritis

Directory of Open Access Journals (Sweden)

O. V. Simonova

2004-01-01

Full Text Available Objective. To evaluate influence of combination therapy with prospidin (P and methotrexate (MTX on X-ray progression, functional status (FS and quality of life (QL in patients with rheumatoid arthritis (RA in comparison with MTX monotherapy. Material and methods. 143 RA pts (129 female and 14 male were studied. Of them, there were. Mean age was 45.5±5.l years. Average duration of the disease was 4.5 years. 20 pts had II and 123 - 111 degree of RA activity. The second X-ray stage according to Steinbroker dominated. 72 pts of group I received P+MTX combination therapy. The therapy included intravenous drip-feed of P 200-300 mg per week in 200ml of 5% glucose and MTX 10 mg per week 1M. The maintaining therapy included P 100-200 mg per week IM and MTX 10 mg per week. 71 patients of group II received MTX monotherapy 10 mg per week. X-ray progression assessment was performed according to Sharp method. FS was evaluated with the HAQ questionnaire, Lee test. QL was evaluated with SF-36 scale. Pts were examined before and after I, 2, 3, 6 and 12 months of treatment. Results. There was no increase of X-ray progression of the disease in case of P+MTX therapy as compared with MTX monotherapy. Both methods resulted in improvement of FS parameters and physical health. Combination therapy significantly improved psychological health as well.

Status and challenges for conservation of small mammal assemblages in South America.

Science.gov (United States)

Kelt, Douglas A; Meserve, Peter L

2014-08-01

South America spans about 44° latitude, covers almost 18 million km(2) , and is second only to Africa in continental mammal species richness. In spite of this richness, research on the status of this fauna and on the nature and magnitude of contemporary threats remains limited. Distilling threats to this diverse fauna at a continental scale is challenging, in part because of the limited availability of rigorous studies. Recognizing this constraint, we summarize key threats to small mammals in South America, emphasizing the roles of habitat loss and degradation, direct persecution, and the increasing threat of climate change. We focus on three regional 'case studies': the tropical Andes, Amazonia and adjacent lowland regions, and the southern temperate region. We close with a brief summary of recent findings at our long-term research site in north-central Chile as they pertain to projected threats to this fauna. Habitat alteration is a pervasive threat that has been magnified by market forces and globalization (e.g. extensive agricultural development in Amazonia), and threatens increasing numbers of populations and species. Climate change poses even greater threats, from changes in rainfall and runoff regimes and resulting changes in vegetative structure and composition to secondary influences on fire dynamics. It is likely that many changes have yet to be recognized, but existing threats suggest that the future may bring dramatic changes in the distribution of many mammal taxa, although it is not clear if key habitat elements (vegetation) will respond as rapidly as climatic factors, leading to substantial uncertainty. Climate change is likely to result in 'winners' and 'losers' but available information precludes detailed assessment of which species are likely to fall into which category. In the absence of long-term monitoring and applied research to characterize these threats more accurately, and to develop strategies to reduce their impacts, managers already are

Research Progress on Measurement Methods and Influence Factors of Thin-film Stress

Directory of Open Access Journals (Sweden)

MA Yibo

2018-02-01

Full Text Available With the size of thin-film electronic devices decreasing, the film stress became an important reason for the failure of thin film devices. Film stress not only affected the membrane structure, but also associated with film optics, electricity, mechanics and other properties, therefore film stress turned into one hot spot in the research field of thin-film materials. This paper reviewed the latest research progress of film stress, substrate curvature method, X-ray diffraction technique and Raman spectroscopy, several frequently used stress measuring techniques were compared and analyzed, and composition ratios of thin film, substrate types, magnetron sputtering process parameters (sputtering power, work pressure, substrate temperature and annealing etc. factors influencing thin film stress were summarized. It was found that substrate curvature method was suitable for measuring almost all kinds of thin film materials. X-ray diffraction and Raman spectroscopy were just fit for measuring materials with characteristic peaks. Nanoindentation method required extra stress-free samples as comparison experiments. During film fabrication and annealing process, film stress usually transited from compressive to tensile status, and several factors combined together could affect stress, so film stress could be reached the minimum value or even stress-free status through setting appropriate parameters. Finally, combined with film stress research status, accurate stress measurement methods for different materials as a thin-film stress research direction were introduced, and challenges in thin film detection range were pointed out.

Role of decommissioning plan and its progress for the PUSPATI TRIGA Reactor

International Nuclear Information System (INIS)

Zakaria, Norasalwa; Mustafa, Muhammad Khairul Ariff; Anuar, Abul Adli; Idris, Hairul Nizam; Ba'an, Rohyiza

2014-01-01

Malaysian nuclear research reactor, the PUSPATI TRIGA Reactor, reached its first criticality in 1982, and since then, it has been serving for more than 30 years for training, radioisotope production and research purposes. Realizing the age and the need for its decommissioning sometime in the future, a ground basis of assessment and an elaborative project management need to be established, covering the entire process from termination of reactor operation to the establishment of final status, documented as the Decommissioning Plan. At international level, IAEA recognizes the absence of Decommissioning Plan as one of the factors hampering progress in decommissioning of nuclear facilities in the world. Throughout the years, IAEA has taken initiatives and drawn out projects in promoting progress in decommissioning programmes, like CIDER, DACCORD and R2D2P, for which Malaysia is participating in these projects. This paper highlights the concept of Decommissioning plan and its significances to the Agency. It will also address the progress, way forward and challenges faced in developing the Decommissioning Plan for the PUSPATI TRIGA Reactor. The efforts in the establishment of this plan helps to provide continual national contribution at the international level, as well as meeting the regulatory requirement, if need be. The existing license for the operation of PUSPATI TRIGA Reactor does not impose a requirement for a decommissioning plan; however, the renewal of license may call for a decommissioning plan to be submitted for approval in future

Role of decommissioning plan and its progress for the PUSPATI TRIGA Reactor

International Nuclear Information System (INIS)

Norasalwa Zakaria; Muhammad Khairul Ariff Mustafa; Abul Adli Anuar; Hairul Nizam Idris; Rohyiza Baan

2013-01-01

Full-text: Malaysian nuclear research reactor, the PUSPATI TRIGA Reactor, reached its first criticality in 1982, and since then, it has been serving for more than 30 years for training, radioisotope production and research purposes. Realizing the age and the need for its decommissioning sometime in the future, a ground basis of assessment and an elaborative project management need to be established, covering the entire process from termination of reactor operation to the establishment of final status, documented as the Decommissioning Plan. At international level, IAEA recognizes the absence of Decommissioning Plan as one of the factors hampering progress in decommissioning of nuclear facilities in the world. Throughout the years, IAEA has taken initiatives and drawn out projects in promoting progress in decommissioning programmes, like CIDER, DACCORD and R2D2P, for which Malaysia is participating in these projects. This paper highlights the concept of Decommissioning plan and its significances to the Agency. It will also address the progress, way forward and challenges faced in developing the Decommissioning Plan for the PUSPATI TRIGA Reactor. The efforts in the establishment of this plan helps to provide continual national contribution at the international level, as well as meeting the regulatory requirement, if need be. The existing license for the operation of PUSPATI TRIGA Reactor does not impose a requirement for a decommissioning plan; however, the renewal of license may call for a decommissioning plan to be submitted for approval in future. (author)

Role of decommissioning plan and its progress for the PUSPATI TRIGA Reactor

Energy Technology Data Exchange (ETDEWEB)

Zakaria, Norasalwa, E-mail: norasalwa@nuclearmalaysia.gov.my; Mustafa, Muhammad Khairul Ariff, E-mail: norasalwa@nuclearmalaysia.gov.my; Anuar, Abul Adli, E-mail: norasalwa@nuclearmalaysia.gov.my; Idris, Hairul Nizam, E-mail: norasalwa@nuclearmalaysia.gov.my; Ba' an, Rohyiza, E-mail: norasalwa@nuclearmalaysia.gov.my [Malaysian Nuclear Agency, 43000 Kajang, Selangor (Malaysia)

2014-02-12

Malaysian nuclear research reactor, the PUSPATI TRIGA Reactor, reached its first criticality in 1982, and since then, it has been serving for more than 30 years for training, radioisotope production and research purposes. Realizing the age and the need for its decommissioning sometime in the future, a ground basis of assessment and an elaborative project management need to be established, covering the entire process from termination of reactor operation to the establishment of final status, documented as the Decommissioning Plan. At international level, IAEA recognizes the absence of Decommissioning Plan as one of the factors hampering progress in decommissioning of nuclear facilities in the world. Throughout the years, IAEA has taken initiatives and drawn out projects in promoting progress in decommissioning programmes, like CIDER, DACCORD and R2D2P, for which Malaysia is participating in these projects. This paper highlights the concept of Decommissioning plan and its significances to the Agency. It will also address the progress, way forward and challenges faced in developing the Decommissioning Plan for the PUSPATI TRIGA Reactor. The efforts in the establishment of this plan helps to provide continual national contribution at the international level, as well as meeting the regulatory requirement, if need be. The existing license for the operation of PUSPATI TRIGA Reactor does not impose a requirement for a decommissioning plan; however, the renewal of license may call for a decommissioning plan to be submitted for approval in future.

Galeras: Progress and challenges of disaster

International Nuclear Information System (INIS)

Dorado G, Lina Marlene

2008-01-01

The Galeras Volcano is presently being considered the most active in Colombia. For the last 17 years of constant vigilance, the occurrence of eruptions by Galeras Volcano has been mostly classified as small ones. In the high hazard zone, live 7935 persons who have to be evacuated every time level II to volcanic activity is reached (probable eruption in the course of days or weeks). For the first time in Colombian history, a disaster situation has been declared before its happening. On November 15th, 2005, the National Government, on the basis of the Decreto 4106, declared the existence of an disaster situation within the counties of Pasto, Narino and La Florida, all making part of the Narino Department. This declaration was made considering the serious alteration of the daily life style, to which the population was exposed due to a probable volcanic eruption, is out to come. The present work is an analysis of the emergency procedures which have been carried out with help of the PAR (pressure and release) methodology. This analysis contains some reflexions on how difficulties were solved, and on positive aspects, challenges and advances for a better long term management of evacuations, like those carried out in the high hazard zones of Galeras volcano

ISIS status report

International Nuclear Information System (INIS)

Finney, J.L.; Gray, D.A.

1989-01-01

The authors review the progress on ISIS, the pulsed neutron source at the Rutherford-Appleton Laboratory, since the last ICANS meeting. The machine is now running regularly at 100 μA at 750 MeV, and delivering neutrons for an increasing UK and international neutron scattering program. The current status of the operating and development instruments is summarized, and some examples given of recent science. 3 refs., 11 figs., 3 tabs

Clay-Inspired MXene-Based Electrochemical Devices and Photo-Electrocatalyst: State-of-the-Art Progresses and Challenges.

Science.gov (United States)

Wang, Hou; Wu, Yan; Yuan, Xingzhong; Zeng, Guangming; Zhou, Jin; Wang, Xin; Chew, Jia Wei

2018-03-01

MXene, an important and increasingly popular category of postgraphene 2D nanomaterials, has been rigorously investigated since early 2011 because of advantages including flexible tunability in element composition, hydrophobicity, metallic nature, unique in-plane anisotropic structure, high charge-carrier mobility, tunable band gap, and favorable optical and mechanical properties. To fully exploit these potentials and further expand beyond the existing boundaries, novel functional nanostructures spanning monolayer, multilayer, nanoparticles, and composites have been developed by means of intercalation, delamination, functionalization, hybridization, among others. Undeniably, the cutting-edge developments and applications of clay-inspired 2D MXene platform as electrochemical electrode or photo-electrocatalyst have conferred superior performance and have made significant impact in the field of energy and advanced catalysis. This review provides an overview of the fundamental properties and synthesis routes of pure MXene, functionalized MXene and their hybrids, highlights the state-of-the-art progresses of MXene-based applications with respect to supercapacitors, batteries, electrocatalysis and photocatalysis, and presents the challenges and prospects in the burgeoning field. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

[The status of the medical profession: reinforced or challenged by the new public management?

Science.gov (United States)

Cascón-Pereira, Rosalía; Kirkpatrick, Ian; Exworthy, Mark

This article aims to assess if the status of the medical profession has been reinforced or weakened with the new public management. With this purpose, it collects the opinion of two international experts regarding situation in the United Kingdom, in order to apply some lessons to the Spanish case. Both agree that, far from losing status and power with the healthcare reform, the medical profession has protected its status and autonomy against other social agents such as managers, politicians and patients. However, the maintenance of the status quo has been at the expense of an intra-professional stratification that has caused status inequalities linked to social class within the medical profession. Copyright © 2016 SESPAS. All rights reserved.

High-dose erythropoietin in patients with progressive multiple sclerosis

DEFF Research Database (Denmark)

Schreiber, Karen; Magyari, Melinda; Sellebjerg, Finn

2017-01-01

BACKGROUND: Erythropoietin (EPO) is a part of an endogenous neuroprotective system in the brain and may address pathophysiological mechanisms in progressive multiple sclerosis (MS). OBJECTIVE: To evaluate a treatment effect of EPO on progressive MS. METHODS: This was a single-center, randomized......, double-blind, placebo-controlled phase 2 trial, in which 52 patients with secondary or primary progressive MS were allocated to treatment with recombinant EPO (48,000 IU) or placebo, administered intravenously 17 times during 24 weeks. Patients had an Expanded Disability Status Score (EDSS) from 4 to 6......: This study provides class II evidence that treatment with high-dose EPO is not an effective treatment in patients with moderately advanced progressive MS....

Material challenges for solar cells in the twenty-first century: directions in emerging technologies

Science.gov (United States)

Delamarre, Amaury; Jehl, Zacharie; Suchet, Daniel; Cojocaru, Ludmila; Giteau, Maxime; Behaghel, Benoit; Julian, Anatole; Ibrahim, Camille; Tatry, Léa; Wang, Haibin; Kubo, Takaya; Uchida, Satoshi; Segawa, Hiroshi; Miyashita, Naoya; Tamaki, Ryo; Shoji, Yasushi; Yoshida, Katsuhisa; Ahsan, Nazmul; Watanabe, Kentaro; Inoue, Tomoyuki; Sugiyama, Masakazu; Nakano, Yoshiaki; Hamamura, Tomofumi; Toupance, Thierry; Olivier, Céline; Chambon, Sylvain; Vignau, Laurence; Geffroy, Camille; Cloutet, Eric; Hadziioannou, Georges; Cavassilas, Nicolas; Rale, Pierre; Cattoni, Andrea; Collin, Stéphane; Gibelli, François; Paire, Myriam; Lombez, Laurent; Aureau, Damien; Bouttemy, Muriel; Etcheberry, Arnaud; Okada, Yoshitaka

2018-01-01

Abstract Photovoltaic generation has stepped up within the last decade from outsider status to one of the important contributors of the ongoing energy transition, with about 1.7% of world electricity provided by solar cells. Progress in materials and production processes has played an important part in this development. Yet, there are many challenges before photovoltaics could provide clean, abundant, and cheap energy. Here, we review this research direction, with a focus on the results obtained within a Japan–French cooperation program, NextPV, working on promising solar cell technologies. The cooperation was focused on efficient photovoltaic devices, such as multijunction, ultrathin, intermediate band, and hot-carrier solar cells, and on printable solar cell materials such as colloidal quantum dots. PMID:29707072

The geothermal partnership: Industry, utilities, and government meeting the challenges of the 90's

Energy Technology Data Exchange (ETDEWEB)

1991-01-01

Each year the Geothermal Division of the US Department of Energy conducts an in-depth review of its entire geothermal R D program. The conference serves several purposes: a status report on current R D activities, an assessment of progress and problems, a review of management issues, and a technology transfer opportunity between DOE and the US geothermal community. This year's conference, Program Review IX, was held in San Francisco on March 19--21, 1991. The theme of this review was The Geothermal Partnership -- Industry, Utilities, and Government Meeting the Challenges of the 90's.'' The importance of this partnership has increased markedly as demands for improved technology must be balanced with available research resources. By working cooperatively, the geothermal community, including industry, utilities, DOE, and other state and federal agencies, can more effectively address common research needs. The challenge currently facing the geothermal partnership is to strengthen the bonds that ultimately will enhance opportunities for future development of geothermal resources. Program Review IX consisted of eight sessions including an opening session. The seven technical sessions included presentations by the relevant field researchers covering DOE-sponsored R D in hydrothermal, hot dry rock, and geopressured energy and the progress associated with the Long Valley Exploratory Well. Individual papers have been cataloged separately.

Measuring and reporting on decommissioning progress

International Nuclear Information System (INIS)

Lange, B.A.

2006-01-01

One of the challenges facing AECL, as well as other organizations charged with the responsibility of decommissioning nuclear facilities, is the means by which to measure and report on decommissioning progress to various audiences which, in some cases, may only have a peripheral knowledge or understanding of the complexities associated with the decommissioning process. The reporting and measurement of decommissioning progress is important for a number of reasons, i.e., It provides a vehicle by which to effectively communicate the nature of the decommissioning process; It ensures that stakeholders and shareholders are provided with a transparent and understandable means for assessing value for money; It provides a means by which to integrate the planning, measurement, and operational aspects of decommissioning One underlying reason behind the challenge of reporting decommissioning progress lies in the fact that decommissioning programs are generally executed over periods of time that far exceed those generally associated with typical design and build projects. For example, a decommissioning program could take decades to complete in which case progress on the order of a few percent in any one year might be typical. However, such progress may appear low compared to that seen with more typical projects that can be completed in a matter of years. As a consequence, AECL undertook to develop a system by which to measure decommissioning progress in a straightforward, meaningful, and understandable fashion. The system is not rigorously objective, and there are subjective aspects that are necessitated by the need to keep the system readily understandable. It is also important to note that while the system is simple in concept, there is, nonetheless, significant effort involved in generating and updating the parameters used as input, and in the actual calculations. (author)

Technological progress and challenges towards cGMP manufacturing of human pluripotent stem cells based therapeutic products for allogeneic and autologous cell therapies.

Science.gov (United States)

Abbasalizadeh, Saeed; Baharvand, Hossein

2013-12-01

Recent technological advances in the generation, characterization, and bioprocessing of human pluripotent stem cells (hPSCs) have created new hope for their use as a source for production of cell-based therapeutic products. To date, a few clinical trials that have used therapeutic cells derived from hESCs have been approved by the Food and Drug Administration (FDA), but numerous new hPSC-based cell therapy products are under various stages of development in cell therapy-specialized companies and their future market is estimated to be very promising. However, the multitude of critical challenges regarding different aspects of hPSC-based therapeutic product manufacturing and their therapies have made progress for the introduction of new products and clinical applications very slow. These challenges include scientific, technological, clinical, policy, and financial aspects. The technological aspects of manufacturing hPSC-based therapeutic products for allogeneic and autologous cell therapies according to good manufacturing practice (cGMP) quality requirements is one of the most important challenging and emerging topics in the development of new hPSCs for clinical use. In this review, we describe main critical challenges and highlight a series of technological advances in all aspects of hPSC-based therapeutic product manufacturing including clinical grade cell line development, large-scale banking, upstream processing, downstream processing, and quality assessment of final cell therapeutic products that have brought hPSCs closer to clinical application and commercial cGMP manufacturing. © 2013.

Treatment progress of diabetic macular edema

Directory of Open Access Journals (Sweden)

Dou Kou

2016-05-01

Full Text Available Diabetic retinopathy(DR,which can cause blindness, is a serious eye diseases. Diabetic macular edema(DME, often causes irreversible vision loss, can occur in any period of DR. The treatment of DME, including laser photocoagulation, anti-inflammatory therapy, anti-VEGF therapy and surgical treatment have made great progress in recent years as the researches on the pathogenesis deepening. The innovation of minimally invasive technique also proved the surgical treatment more convenience. The joint application of a variety of treatments, also become the main trend of treatment. A review of the present status and progress of the treatment was made in this paper.

Nutritional status in patients with hepatitis C

International Nuclear Information System (INIS)

Ismail, F.W.; Khan, R.A.; Kamani, L.; Shah, H.A.; Jafri, W.

2012-01-01

To assess the nutritional status via the SGA (subjective global assessment) screening tool of patients at all stages of hepatitis C virus (HCV) liver disease. Study Design: Descriptive study. Place and Duration of Study: Out-patient Clinics of the Aga Khan University Hospital, Karachi, conducted from October 2009 to January 2011. Methodology: Patients with hepatitis C virus infection and their HCV-negative attendants were enrolled from the outpatient clinics, and categorized into 4 groups of 100 patients each: healthy controls (HC), those with chronic hepatitis C infection (CHC), compensated cirrhotics (CC) and decompensated cirrhotics (DC). The validated subjective global assessment (SGA) tool was used to assess nutritional status. Results: A total of 400 patients were enrolled. Most of the patients in the HC group were class 'A' (best nutritional status). In contrast, the majority (64%) in the DC group were in the class 'C' (worst status). The compensated cirrhosis (CC) group showed that 90% of patients were malnourished, while 98% of all patients were malnourished in the DC group, predominantly class 'C'. Most importantly, 14% of patients with chronic hepatitis C (CHC) also scored a 'B' on the SGA; which when compared to HC was statistically significant (p=0.005). As the groups progressed in their disease from CHC to DC, the transition in nutritional status from 'A' to 'C' between groups was statistically significant. Conclusion: Malnutrition occurs early in the course of HCV, and progresses relentlessly throughout the spectrum of HCV disease. (author)

Ovarian cancer immunotherapy: opportunities, progresses and challenges

Directory of Open Access Journals (Sweden)

Stevens Richard

2010-02-01

Full Text Available Abstract Due to the low survival rates from invasive ovarian cancer, new effective treatment modalities are urgently needed. Compelling evidence indicates that the immune response against ovarian cancer may play an important role in controlling this disease. We herein summarize multiple immune-based strategies that have been proposed and tested for potential therapeutic benefit against advanced stage ovarian cancer. We will examine the evidence for the premise that an effective therapeutic vaccine against ovarian cancer is useful not only for inducing remission of the disease but also for preventing disease relapse. We will also highlight the questions and challenges in the development of ovarian cancer vaccines, and critically discuss the limitations of some of the existing immunotherapeutic strategies. Finally, we will summarize our own experience on the use of patient-specific tumor-derived heat shock protein-peptide complex for the treatment of advanced ovarian cancer.

Radiomic analysis in prediction of Human Papilloma Virus status.

Science.gov (United States)

Yu, Kaixian; Zhang, Youyi; Yu, Yang; Huang, Chao; Liu, Rongjie; Li, Tengfei; Yang, Liuqing; Morris, Jeffrey S; Baladandayuthapani, Veerabhadran; Zhu, Hongtu

2017-12-01

Human Papilloma Virus (HPV) has been associated with oropharyngeal cancer prognosis. Traditionally the HPV status is tested through invasive lab test. Recently, the rapid development of statistical image analysis techniques has enabled precise quantitative analysis of medical images. The quantitative analysis of Computed Tomography (CT) provides a non-invasive way to assess HPV status for oropharynx cancer patients. We designed a statistical radiomics approach analyzing CT images to predict HPV status. Various radiomics features were extracted from CT scans, and analyzed using statistical feature selection and prediction methods. Our approach ranked the highest in the 2016 Medical Image Computing and Computer Assisted Intervention (MICCAI) grand challenge: Oropharynx Cancer (OPC) Radiomics Challenge, Human Papilloma Virus (HPV) Status Prediction. Further analysis on the most relevant radiomic features distinguishing HPV positive and negative subjects suggested that HPV positive patients usually have smaller and simpler tumors.

Progress Toward Containment of Poliovirus Type 2 - Worldwide, 2017.

Science.gov (United States)

Previsani, Nicoletta; Singh, Harpal; St Pierre, Jeanette; Boualam, Liliane; Fournier-Caruana, Jacqueline; Sutter, Roland W; Zaffran, Michel

2017-06-23

The Global Polio Eradication Initiative (GPEI) continues to make progress toward the eradication target. Only one of the three serotypes, wild poliovirus (WPV) type 1 (WPV1), is still circulating, and the numbers of cases and countries with endemic transmission are at record lows. With the certification of wild poliovirus type 2 (WPV2) eradication in 2015 and the global replacement of trivalent oral poliovirus vaccine (tOPV) containing Sabin poliovirus types 1, 2, and 3 with bivalent OPV containing only Sabin poliovirus types 1 and 3 during April-May 2016, poliovirus type 2 (PV2) is now an eradicated pathogen. However, in eight countries (Cameroon, Chad, Democratic Republic of Congo, Mozambique, Niger, Nigeria, Pakistan, and Syria), monovalent type 2 OPV (mOPV2) was authorized for large-scale outbreak control after tOPV withdrawal (1). Poliovirus containment, an evolving area of work that affects every country, aims to ensure that all PV2 specimens are safely contained to minimize the risk for reintroducing the virus into communities. This report summarizes the current status of poliovirus containment and progress since the last report (2), and outlines remaining challenges. Within 30 countries, 86 facilities have been designated by the relevant national authorities (usually the Ministry of Health) to become poliovirus-essential facilities for the continued storage or handling of PV2 materials; each country is responsible for ensuring that these facilities meet all biorisk management requirements.

An exploratory study on the building information modeling adoption in United Arab Emirates municipal projects- current status and challenges

Directory of Open Access Journals (Sweden)

Venkatachalam Senthilkumar

2017-01-01

Full Text Available Many modern complex building projects in the public and private sectors are characterized by its poor information management which is manifested by time and cost overruns around the world. Building Information Modelling (BIM is currently being adopted around the world with various countries mandated its implementation. In specific, the implementation of BIM is rapidly growing in developed countries such as USA, UK, Singapore and Australia, with government mandate through devising strategies and initiatives to increase the adoption. The implementation of BIM in United Arab Emirates (UAE and other developing countries lags behind due to the existence of numerous implementation barriers. This study explores the current status of BIM implementation in the UAE municipalities, further explores the people, process and technology readiness towards BIM adoption in the UAE building projects. Further the study also explores the current challenges against the BIM adoption. The study adopts a positivists approach by collecting data through questionnaires, a sample of sixty participants across the UAE municipalities from different states were selected randomly to acquire the data. The collected data is statistically analyzed to obtain the findings. The analysis results showed that there are inadequate people and process related readiness towards BIM adoption whereas the technology readiness does exist. The same also was reflected in further analysis on BIM adoption barriers as the challenges. Further the paper also discusses the possible strategies adopted around the world through literature to address the explored challenges in the study

CERN concludes year of strong progress towards the LHC

CERN Multimedia

2006-01-01

Speaking at the 135th session of the CERN Council, the Director General, Robert Aymar, hailed a year of impressive progress towards the LHC project. 'In one year, we have made great progress,' he said. 'The challenge is not over, of course, but we have great confidence of maintaining the schedule for start-up in 2007.'

Challenges facing production grids

Energy Technology Data Exchange (ETDEWEB)

Pordes, Ruth; /Fermilab

2007-06-01

Today's global communities of users expect quality of service from distributed Grid systems equivalent to that their local data centers. This must be coupled to ubiquitous access to the ensemble of processing and storage resources across multiple Grid infrastructures. We are still facing significant challenges in meeting these expectations, especially in the underlying security, a sustainable and successful economic model, and smoothing the boundaries between administrative and technical domains. Using the Open Science Grid as an example, I examine the status and challenges of Grids operating in production today.

Childhood Obesity – 2010: Progress and Challenges

Science.gov (United States)

Han, Joan C.; Lawlor, Debbie A.; Kimm, Sue Y.S.

2010-01-01

Summary The worldwide prevalence of childhood obesity has increased greatly over the past 3 decades. The increasing occurrence in children of disorders, such as type 2 diabetes, is believed to be a consequence of this obesity epidemic. Much progress has been made in understanding the genetics and physiology of appetite control and from this, the elucidation of the causes of some rare obesity syndromes. However, these rare disorders have so far taught us only limited lessons on how to prevent or reverse obesity in most children. Calorie intake and activity recommendations need to be re-assessed and better quantified, on a population level, given the more sedentary life of children today. For individual treatment, the currently recommended calorie prescriptions may be too conservative given the evolving insight on the “energy gap.” Whilst quality of research in both prevention and treatment has improved, there is still a need for high-quality multi-centre trials with long-term follow-up. Meanwhile, prevention and treatment approaches that aim to increase energy expenditure and decrease intake need to continue. Most recently, the spiralling increase in obesity prevalence may be abating for children. Thus, even greater efforts need to be made on all fronts to continue this potentially exciting trend. PMID:20451244

Moving from the HIV Organ Policy Equity Act to HIV Organ Policy Equity in action: changing practice and challenging stigma.

Science.gov (United States)

Doby, Brianna L; Tobian, Aaron A R; Segev, Dorry L; Durand, Christine M

2018-04-01

The HIV Organ Policy Equity (HOPE) Act, signed in 2013, reversed the federal ban on HIV-to-HIV transplantation. In this review, we examine the progress in HOPE implementation, the current status of HIV-to-HIV transplantation, and remaining challenges. Pursuant to the HOPE Act, the Department of Health and Human Services revised federal regulations to allow HIV-to-HIV transplants under research protocols adherent to criteria published by the National Institutes of Health. The first HIV-to-HIV kidney and liver transplants were performed at Johns Hopkins in March of 2016. Legal and practical challenges remain. Further efforts are needed to educate potential HIV+ donors and to support Organ Procurement Organizations. As of November 2017, there are 22 transplant centers approved to perform HIV-to-HIV transplants in 10 United Network for Organ Sharing regions. To date, 16 Organ Procurement Organizations in 22 states have evaluated HIV+ donors. The National Institutes of Health-funded HOPE in Action: A Multicenter Clinical Trial of HIV-to-HIV Deceased Donor (HIVDD) Kidney Transplantation Kidney Trial will launch at 19 transplant centers in December of 2017. A HOPE in Action Multicenter HIVDD Liver Trial is in development. Significant progress toward full HOPE implementation has been made though barriers remain. Some challenges are unique to HIV-HIV transplantation, whereas others are amplifications of issues across the current transplant system. In addition to a public health benefit for all transplant candidates in the United States, partnership on the HOPE Act has the potential to address systemic challenges to national donation and transplantation.

A biodiversity indicators dashboard: addressing challenges to monitoring progress towards the Aichi biodiversity targets using disaggregated global data.

Science.gov (United States)

Han, Xuemei; Smyth, Regan L; Young, Bruce E; Brooks, Thomas M; Sánchez de Lozada, Alexandra; Bubb, Philip; Butchart, Stuart H M; Larsen, Frank W; Hamilton, Healy; Hansen, Matthew C; Turner, Will R

2014-01-01

Recognizing the imperiled status of biodiversity and its benefit to human well-being, the world's governments committed in 2010 to take effective and urgent action to halt biodiversity loss through the Convention on Biological Diversity's "Aichi Targets". These targets, and many conservation programs, require monitoring to assess progress toward specific goals. However, comprehensive and easily understood information on biodiversity trends at appropriate spatial scales is often not available to the policy makers, managers, and scientists who require it. We surveyed conservation stakeholders in three geographically diverse regions of critical biodiversity concern (the Tropical Andes, the African Great Lakes, and the Greater Mekong) and found high demand for biodiversity indicator information but uneven availability. To begin to address this need, we present a biodiversity "dashboard"--a visualization of biodiversity indicators designed to enable tracking of biodiversity and conservation performance data in a clear, user-friendly format. This builds on previous, more conceptual, indicator work to create an operationalized online interface communicating multiple indicators at multiple spatial scales. We structured this dashboard around the Pressure-State-Response-Benefit framework, selecting four indicators to measure pressure on biodiversity (deforestation rate), state of species (Red List Index), conservation response (protection of key biodiversity areas), and benefits to human populations (freshwater provision). Disaggregating global data, we present dashboard maps and graphics for the three regions surveyed and their component countries. These visualizations provide charts showing regional and national trends and lay the foundation for a web-enabled, interactive biodiversity indicators dashboard. This new tool can help track progress toward the Aichi Targets, support national monitoring and reporting, and inform outcome-based policy-making for the protection of

A biodiversity indicators dashboard: addressing challenges to monitoring progress towards the Aichi biodiversity targets using disaggregated global data.

Directory of Open Access Journals (Sweden)

Xuemei Han

Full Text Available Recognizing the imperiled status of biodiversity and its benefit to human well-being, the world's governments committed in 2010 to take effective and urgent action to halt biodiversity loss through the Convention on Biological Diversity's "Aichi Targets". These targets, and many conservation programs, require monitoring to assess progress toward specific goals. However, comprehensive and easily understood information on biodiversity trends at appropriate spatial scales is often not available to the policy makers, managers, and scientists who require it. We surveyed conservation stakeholders in three geographically diverse regions of critical biodiversity concern (the Tropical Andes, the African Great Lakes, and the Greater Mekong and found high demand for biodiversity indicator information but uneven availability. To begin to address this need, we present a biodiversity "dashboard"--a visualization of biodiversity indicators designed to enable tracking of biodiversity and conservation performance data in a clear, user-friendly format. This builds on previous, more conceptual, indicator work to create an operationalized online interface communicating multiple indicators at multiple spatial scales. We structured this dashboard around the Pressure-State-Response-Benefit framework, selecting four indicators to measure pressure on biodiversity (deforestation rate, state of species (Red List Index, conservation response (protection of key biodiversity areas, and benefits to human populations (freshwater provision. Disaggregating global data, we present dashboard maps and graphics for the three regions surveyed and their component countries. These visualizations provide charts showing regional and national trends and lay the foundation for a web-enabled, interactive biodiversity indicators dashboard. This new tool can help track progress toward the Aichi Targets, support national monitoring and reporting, and inform outcome-based policy-making for the

A Biodiversity Indicators Dashboard: Addressing Challenges to Monitoring Progress towards the Aichi Biodiversity Targets Using Disaggregated Global Data

Science.gov (United States)

Han, Xuemei; Smyth, Regan L.; Young, Bruce E.; Brooks, Thomas M.; Sánchez de Lozada, Alexandra; Bubb, Philip; Butchart, Stuart H. M.; Larsen, Frank W.; Hamilton, Healy; Hansen, Matthew C.; Turner, Will R.

2014-01-01

Recognizing the imperiled status of biodiversity and its benefit to human well-being, the world's governments committed in 2010 to take effective and urgent action to halt biodiversity loss through the Convention on Biological Diversity's “Aichi Targets”. These targets, and many conservation programs, require monitoring to assess progress toward specific goals. However, comprehensive and easily understood information on biodiversity trends at appropriate spatial scales is often not available to the policy makers, managers, and scientists who require it. We surveyed conservation stakeholders in three geographically diverse regions of critical biodiversity concern (the Tropical Andes, the African Great Lakes, and the Greater Mekong) and found high demand for biodiversity indicator information but uneven availability. To begin to address this need, we present a biodiversity “dashboard” – a visualization of biodiversity indicators designed to enable tracking of biodiversity and conservation performance data in a clear, user-friendly format. This builds on previous, more conceptual, indicator work to create an operationalized online interface communicating multiple indicators at multiple spatial scales. We structured this dashboard around the Pressure-State-Response-Benefit framework, selecting four indicators to measure pressure on biodiversity (deforestation rate), state of species (Red List Index), conservation response (protection of key biodiversity areas), and benefits to human populations (freshwater provision). Disaggregating global data, we present dashboard maps and graphics for the three regions surveyed and their component countries. These visualizations provide charts showing regional and national trends and lay the foundation for a web-enabled, interactive biodiversity indicators dashboard. This new tool can help track progress toward the Aichi Targets, support national monitoring and reporting, and inform outcome-based policy-making for the

Composting of food wastes: Status and challenges.

Science.gov (United States)

Cerda, Alejandra; Artola, Adriana; Font, Xavier; Barrena, Raquel; Gea, Teresa; Sánchez, Antoni

2018-01-01

This review analyses the main challenges of the process of food waste composting and examines the crucial aspects related to the quality of the produced compost. Although recent advances have been made in crucial aspects of the process, such composting microbiology, improvements are needed in process monitoring. Therefore, specific problems related to food waste composting, such as the presence of impurities, are thoroughly analysed in this study. In addition, environmental impacts related to food waste composting, such as emissions of greenhouse gases and odours, are discussed. Finally, the use of food waste compost in soil bioremediation is discussed in detail. Copyright © 2017 Elsevier Ltd. All rights reserved.

Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children

Directory of Open Access Journals (Sweden)

Camila Pugliese

2014-09-01

Conclusion: HIV-infected children have an inadequate selenium and copper nutritional status, which could influence the progression to AIDS. An adequate micronutrient status could improve the clinical conditions in these patients and minimize free radical production and cellular oxidative stress.

Schedule and status of irradiation experiments

International Nuclear Information System (INIS)

Rowcliffe, A.F.; Grossbeck, M.L.; Robertson, J.P.

1998-01-01

The current status of reactor irradiation experiments is presented in tables summarizing the experimental objectives, conditions, and schedule. Currently, the program has four irradiation experiments in reactor, and five experiments in the design or construction stages. Postirradiation examination and testing is in progress on ten experiments

UNECE renewable energy status report 2015

International Nuclear Information System (INIS)

Uherova Hasbani, Katarina; Burlui, Ludmila; Hullin, Martin; Akande, Dennis; Koshy, Shweta; Sambucini, Gianluca; Townsend, David; Dobrotkova, Zuzana; Repikova, Martina; Mitsay, Andriy

2015-01-01

The United Nations Economic Commission for Europe (UNECE) covers a large and diverse region comprising 56 member states. These countries have different energy situations and vary in their potential for and progress in renewable energy and energy efficiency. The present report covers 17 UNECE countries, with the aim of establishing a data baseline and providing a general overview of their renewable energy situations. Over the past decade, the national governments of the selected countries have been working actively to leverage this renewable energy potential. Energy security and access to reliable, affordable, sustainable and modern energy are the key concerns driving renewable energy deployment. These countries require more substantial investment to fully realise its renewable potential and to bring innovative solutions to tackle their energy challenges, such as heating in urban and rural areas. A reliable data baseline is a pre-requisite and an enabler for more investment activity. The UNECE has contributed actively to fulfilling the 17 countries' aspirations in renewable energy by providing them with a platform for collaboration among UNECE member states. In 2014, a UNECE Group of Experts on Renewable Energy was established to step up these efforts. Its mandate is to carry out action-oriented, practical activities to significantly increase the uptake of renewable energy, in line with the United Nations Secretary-General's Sustainable Energy for All (SE4All) initiative. This UNECE Renewable Energy Status Report strives to present analysis of up-to-date data and information on the status of renewable energy and energy efficiency in the selected countries of the UNECE region

Nationwide Natural Resource Inventory of the Philippines Using Lidar: Strategies, Progress, and Challenges

Science.gov (United States)

Blanco, A. C.; Tamondong, A.; Perez, A. M.; Ang, M. R. C.; Paringit, E.; Alberto, R.; Alibuyog, N.; Aquino, D.; Ballado, A.; Garcia, P.; Japitana, M.; Ignacio, M. T.; Macandog, D.; Novero, A.; Otadoy, R. E.; Regis, E.; Rodriguez, M.; Silapan, J.; Villar, R.

2016-06-01

The Philippines has embarked on a detailed nationwide natural resource inventory using LiDAR through the Phil-LiDAR 2 Program. This 3-year program has developed and has been implementing mapping methodologies and protocols to produce high-resolution maps of agricultural, forest, coastal marine, hydrological features, and renewable energy resources. The Program has adopted strategies on system and process development, capacity building and enhancement, and expanding the network of collaborations. These strategies include training programs (on point cloud and image processing, GIS, and field surveys), workshops, forums, and colloquiums (program-wide, cluster-based, and project-based), and collaboration with partner national government agencies and other organizations. In place is a cycle of training, implementation, and feedback in order to continually improve the system and processes. To date, the Program has achieved progress in the development of workflows and in rolling out products such as resource maps and GIS data layers, which are indispensable in planning and decision-making. Challenges remains in speeding up output production (including quality checks) and in ensuring sustainability considering the short duration of the program. Enhancements in the workflows and protocols have been incorporated to address data quality and data availability issues. More trainings have been conducted for project staff hired to address human resource gaps. Collaborative arrangements with more partners are being established. To attain sustainability, the Program is developing and instituting a system of training, data updating and sharing, information utilization, and feedback. This requires collaboration and cooperation of the government agencies, LGUs, universities, other organizations, and the communities.

Cloud ice: A climate model challenge with signs and expectations of progress

Science.gov (United States)

Waliser, Duane E.; Li, Jui-Lin F.; Woods, Christopher P.; Austin, Richard T.; Bacmeister, Julio; Chern, Jiundar; Del Genio, Anthony; Jiang, Jonathan H.; Kuang, Zhiming; Meng, Huan; Minnis, Patrick; Platnick, Steve; Rossow, William B.; Stephens, Graeme L.; Sun-Mack, Szedung; Tao, Wei-Kuo; Tompkins, Adrian M.; Vane, Deborah G.; Walker, Christopher; Wu, Dong

2009-04-01

Present-day shortcomings in the representation of upper tropospheric ice clouds in general circulation models (GCMs) lead to errors in weather and climate forecasts as well as account for a source of uncertainty in climate change projections. An ongoing challenge in rectifying these shortcomings has been the availability of adequate, high-quality, global observations targeting ice clouds and related precipitating hydrometeors. In addition, the inadequacy of the modeled physics and the often disjointed nature between model representation and the characteristics of the retrieved/observed values have hampered GCM development and validation efforts from making effective use of the measurements that have been available. Thus, even though parameterizations in GCMs accounting for cloud ice processes have, in some cases, become more sophisticated in recent years, this development has largely occurred independently of the global-scale measurements. With the relatively recent addition of satellite-derived products from Aura/Microwave Limb Sounder (MLS) and CloudSat, there are now considerably more resources with new and unique capabilities to evaluate GCMs. In this article, we illustrate the shortcomings evident in model representations of cloud ice through a comparison of the simulations assessed in the Intergovernmental Panel on Climate Change Fourth Assessment Report, briefly discuss the range of global observational resources that are available, and describe the essential components of the model parameterizations that characterize their "cloud" ice and related fields. Using this information as background, we (1) discuss some of the main considerations and cautions that must be taken into account in making model-data comparisons related to cloud ice, (2) illustrate present progress and uncertainties in applying satellite cloud ice (namely from MLS and CloudSat) to model diagnosis, (3) show some indications of model improvements, and finally (4) discuss a number of

Canada's climate change voluntary challenge and registry program : 6. annual progress report

International Nuclear Information System (INIS)

2000-10-01

A Canadian integrated energy company, Suncor Energy Inc. comprises a corporate group, three operating business units, and two emerging businesses. This annual Progress Report for Canada's Climate Change Voluntary Challenge and Registry (VCR) Program represents the sixth for this company. Suncor is committed to sustainable development. Some initiatives undertaken in 1999 by Suncor included: Oil Sands Project Millennium, which will more than double the actual production of crude oil and fuel products by 2002. Suncor is divesting of conventional oil properties in order to concentrate on exploration and production of natural gas. Alternative and renewable energy will see an investment of 100 million over the next five years. The money will be allocated to research and development, the production of fuels from biomass, and conversion of municipal solid waste to energy through the recovery of methane from landfills. Since 1990, the emissions of carbon dioxide have been reduced to 14 per cent below 1990 levels, and reductions of 622, 000 tonnes of greenhouse gases. A comprehensive tracking, reporting, and management system for greenhouse gases was implemented. Ongoing improvements in quality and comprehensiveness have validated the methodology used to monitor emissions inventories and sources. Initiatives in internal and external awareness of greenhouse gases education were implemented, such as speaking engagements at climate change activities, the retrofit of schools with advanced energy-efficient technology, education programs, employee suggestion programs, etc. Collaboration with external partners on research and development projects represents a major building block in this approach. Some of the research and development projects involve the development of advanced carbon dioxide capture and geologic sequestration technologies, work on the production of alternative and renewable energy from Canadian municipal landfills, and the study of a new process to extract heavy

Southeastern Community College Annual Progress Report, December 1995.

Science.gov (United States)

Gardner, R. Gene

Presenting information on the status of Southeastern Community College (SCC), in Iowa, this annual progress report highlights basic institutional data, financial information, and improvements and planned changes of the college as of 1995. Part 1 presents basic data on SCC, including facility locations, assessed property valuation, district…

Preclinical magnetic resonance imaging and systems biology in cancer research: current applications and challenges.

Science.gov (United States)

Albanese, Chris; Rodriguez, Olga C; VanMeter, John; Fricke, Stanley T; Rood, Brian R; Lee, YiChien; Wang, Sean S; Madhavan, Subha; Gusev, Yuriy; Petricoin, Emanuel F; Wang, Yue

2013-02-01

Biologically accurate mouse models of human cancer have become important tools for the study of human disease. The anatomical location of various target organs, such as brain, pancreas, and prostate, makes determination of disease status difficult. Imaging modalities, such as magnetic resonance imaging, can greatly enhance diagnosis, and longitudinal imaging of tumor progression is an important source of experimental data. Even in models where the tumors arise in areas that permit visual determination of tumorigenesis, longitudinal anatomical and functional imaging can enhance the scope of studies by facilitating the assessment of biological alterations, (such as changes in angiogenesis, metabolism, cellular invasion) as well as tissue perfusion and diffusion. One of the challenges in preclinical imaging is the development of infrastructural platforms required for integrating in vivo imaging and therapeutic response data with ex vivo pathological and molecular data using a more systems-based multiscale modeling approach. Further challenges exist in integrating these data for computational modeling to better understand the pathobiology of cancer and to better affect its cure. We review the current applications of preclinical imaging and discuss the implications of applying functional imaging to visualize cancer progression and treatment. Finally, we provide new data from an ongoing preclinical drug study demonstrating how multiscale modeling can lead to a more comprehensive understanding of cancer biology and therapy. Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Yucca Mountain Project technical status report (TSR), October 1989--March 1990

International Nuclear Information System (INIS)

1990-01-01

This Yucca Mountain Project Technical Status Report (TSR) on site characterization is the second in a series of reports that will be issued at approximately six-month intervals during site characterization. In addition, progress made toward the initiation and conduct of new site characterization activities is included. For this report, information on the technical progress made by Yucca Mountain Project participating organizations has been compiled covering the period from October 1989, through March 31, 1990. The status report consists of three sections: an introductory section; a section on the status of site characterization, which includes preparatory activities, sites programs, repository design, seals system design, waste package design, and performance assessment; and a reference section, which provides a complete listing of all published documents cited in the text. 59 refs

Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress.

Science.gov (United States)

Zhang, Xiao-Liang; Pang, Wei; Hu, Xin-Tian; Li, Jia-Li; Yao, Yong-Gang; Zheng, Yong-Tang

2014-11-18

Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China's growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China's life sciences and pharmaceutical industry, and enhance China's position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective countermeasures to better utilize NHP resources and further foster NHP research in China.

Geothermal Progress Monitor, report No. 13

Energy Technology Data Exchange (ETDEWEB)

1992-02-01

Geothermal Progress Monitor (GPM) Issue No. 13 documents that most related factors favor the growth and geographic expansion of the US geothermal industry and that the industry is being technologically prepared to meet those challenges into the next century. It is the function of GPM to identify trends in the use of this resource and to provide a historical record of its development pathway. The information assembled for this issue of GPM indicates that trends in the use of geothermal energy in this country and abroad continue to be very positive. Favorable sentiments as well as pertinent actions on the part of both government and industry are documented in almost every section. The FEDERAL BEAT points up that the National Energy Strategy (NES) developed at the highest levels of the US government recognizes the environmental and energy security advantages of renewable energy, including geothermal, and makes a commitment to substantial diversification'' of US sources of energy. With the announcement of the construction of several new plants and plant expansions, the INDUSTRY SCENE illustrates industry's continued expectation tha the use of geothermal energy will prove profitable to investors. In DEVELOPMENT STATUS, spokesmen for both an investor-owned utility and a major geothermal developer express strong support for geothermal power, particularly emphasizing its environmental advantages. DEVELOPMENT STATUS also reports that early successes have been achieved by joint DOE/industry R D at The Geysers which will have important impacts on the future management of this mature field. Also there is increasing interest in hot dry rock. Analyses conducted in support of the NES indicate that if all the postulated technology developments occur in this field, the price of energy derived from hot dry rock in the US could drop.

Case management considerations of progressive dementia in a home setting.

Science.gov (United States)

Pierce, Mary Ellen

2010-01-01

Nursing theory, research, and best practice guidelines contribute substantially to the field of dementia care. Interventional plans are challenged most by those dementias considered progressive and deteriorative in nature, requiring ongoing reassessment and modification of care practices as the clinical course changes. The purpose of this article is to provide guidelines for case managers in the development of effective, individualized care plans for clients with progressive dementia residing in a home setting. The application of these guidelines is illustrated through the presentation of an actual case. The practice setting is a private home in the Pacific Northwest. Geriatric case management is provided by an RN case manager. Progressive dementia presents challenges to home care. Professional case management using comprehensive, holistic assessment, collaborative approaches, and best practice fundamentals serve to create an effective, individualized plan of care. The increasing geriatric population presents great opportunities for case managers in strategic management for creating successful home care models in clients with progressive dementia. Use of nursing diagnoses, dementia research, and collaborative approaches with families and other medical providers creates a viable alternative for clients with progressive dementia.

[Research progress on fascioliasis].

Science.gov (United States)

Liu, Qian; Cheng, Na; Zhou, Yan; Xu, Xue-Nian

2013-06-01

Fascioliasis is an important zoonosis caused by Fasciola spp. It can cause pathological damages to human liver and gallbladder, as well as economic loss in animal husbandry. Fascioliasis can be easily misdiagnosed with other hepatobiliary diseases. The appearance of resistance to triclabendazole is an issue problem for fascioliasis control. Therefore, research for better diagnostic methods, effective drugs and vaccines become to the focus of fascioliasis control. This article summarizes the progress on epidemiological status, diagnostic method, therapy, drug resistance, vaccine and omics of fascioliasis.

Challenges and status of multi-unit PSA development in Canada

International Nuclear Information System (INIS)

Yalaoui, Smain

2015-01-01

Firstly, this paper discusses the issues and challenges related to the development of a Multi-Unit PSA (MU-PSA) and the general recommendations and conclusions from the MU-PSA Workshop organized by the CNSC in Ottawa, November 2014. This includes a discussion regarding the issue related to the methodological challenges in performing MU-PSA, the site-based risk metrics to be adopted, and the issue of risk aggregation across all hazards and all units. The paper also addresses the challenges for establishing site-based safety goals as the current safety goals were established on a per-unit basis. CNSC Staff efforts, both at the national and international level, on developing whole-site safety goals and guidance on MU-PSA and risk aggregation methodologies will also be discussed. Finally, the paper will provide a summary of the industry effort and road map for completing the pilot Whole-site PSA project for the Pickering Nuclear Generating Station, as requested by the Commission following to the public hearing for licence renewal in February 20 and May 29-31, 2013. (author)

Challenges: a state and compact perspective

International Nuclear Information System (INIS)

Brown, H.

1987-01-01

The challenges facing states and compacts in their efforts to implement the Low-Level Waste Policy Amendments Act are described. Institutional challenges include: small-volume sites; compact maintenance; shifting agencies and changing personnel; and timing of progress. The technical challenge lies in the enormous number of plans, procedures, and regulations that have to be developed over the next four years. There are two main fiscal challenges: funding of day-to-day operations of compact commissions; and financing the siting and construction of new disposal sites. There are also two main regulatory challenges: host states must develop regulations for siting and selection of technology; and all states have to await federal regulations to be completed. The final challenge is political: whether a region can overcome public opposition and actually site a facility

Multiagent Work Practice Simulation: Progress and Challenges

Science.gov (United States)

Clancey, William J.; Sierhuis, Maarten

2002-01-01

Modeling and simulating complex human-system interactions requires going beyond formal procedures and information flows to analyze how people interact with each other. Such work practices include conversations, modes of communication, informal assistance, impromptu meetings, workarounds, and so on. To make these social processes visible, we have developed a multiagent simulation tool, called Brahms, for modeling the activities of people belonging to multiple groups, situated in a physical environment (geographic regions, buildings, transport vehicles, etc.) consisting of tools, documents, and computer systems. We are finding many useful applications of Brahms for system requirements analysis, instruction, implementing software agents, and as a workbench for relating cognitive and social theories of human behavior. Many challenges remain for representing work practices, including modeling: memory over multiple days, scheduled activities combining physical objects, groups, and locations on a timeline (such as a Space Shuttle mission), habitat vehicles with trajectories (such as the Shuttle), agent movement in 3d space (e.g., inside the International Space Station), agent posture and line of sight, coupled movements (such as carrying objects), and learning (mimicry, forming habits, detecting repetition, etc.).

Progress and challenges of the bioartificial pancreas

Science.gov (United States)

Hwang, Patrick T. J.; Shah, Dishant K.; Garcia, Jacob A.; Bae, Chae Yun; Lim, Dong-Jin; Huiszoon, Ryan C.; Alexander, Grant C.; Jun, Ho-Wook

2016-11-01

Pancreatic islet transplantation has been validated as a treatment for type 1 diabetes since it maintains consistent and sustained type 1 diabetes reversal. However, one of the major challenges in pancreatic islet transplantation is the body's natural immune response to the implanted islets. Immunosuppressive drug treatment is the most popular immunomodulatory approach for islet graft survival. However, administration of immunosuppressive drugs gives rise to negative side effects, and long-term effects are not clearly understood. A bioartificial pancreas is a therapeutic approach to enable pancreatic islet transplantation without or with minimal immune suppression. The bioartificial pancreas encapsulates the pancreatic islets in a semi-permeable environment which protects islets from the body's immune responses, while allowing the permeation of insulin, oxygen, nutrients, and waste. Many groups have developed various types of the bioartificial pancreas and tested their efficacy in animal models. However, the clinical application of the bioartificial pancreas still requires further investigation. In this review, we discuss several types of bioartificial pancreases and address their advantages and limitations. We also discuss recent advances in bioartificial pancreas applications with microfluidic or micropatterning technology.

Communication of nuclear data progress: No.15 (1996)

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-06-01

Communication of Nuclear Data Progress (CNDP) is set up by Chinese Nuclear DATA Center. This is the 15th issue. The nuclear data achievements and progress in China during the last year are presented. It mainly includes: the measurements of the energy spectrum and angular distributions of protons from stainless steel bombarded by 14.6 MeV neutrons, theoretical calculations of {sup 59}Co and {sup 90}Zr neutron reaction data, the method and program CABEI for adjusting consistency between natural and its isotope data, {sup 58,60,61,62,64,Nat}Ni(n, p), {sup 59}Co, {sup 90}Zr(n,x) and {sup 84}Rb decay data, the status of CENDL-2.1 and progress on Chinese Evaluated Nuclear Parameter Library.

The Waste Treatment Plant, a Work in Progress

International Nuclear Information System (INIS)

Hamel, W. F. Jr.; Duncan, G. M.

2006-01-01

There are many challenges in the design and construction of Department of Energy's (DOE) Waste Treatment and Immobilization Plant (WTP) at the Hanford site. The plant is being built to process some 55 million gallons of radioactive waste from 177 underground tanks. Engineering and construction are progressing on this largest project in the DOE complex. This paper describes some of WTP's principal recent challenges and opportunities and how they are being addressed to minimize impact on the project, enhance the capabilities of the facilities, and reduce risk. A significant new development in 2005 was the need to account for higher seismic accelerations than originally specified for the facility structures and equipment. Efforts have centered on continuing design and construction with minimal risk, while the final seismic design spectra was developed. Other challenges include development of an alternative cesium ion exchange resin to minimize the risk from reliance on a single product, implementing advanced analytical techniques to improve laboratory performance, adopting a thinner walled high level waste (HLW) canister to reduce waste volume and mission duration, and commissioning a comprehensive external flowsheet review of the design, along with its underpinning technologies, and projected plant operability. These challenges make it clear that WTP is a work in progress, but the challenges are being successfully resolved as the design and construction move on to completion. (authors)

A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations.

Science.gov (United States)

Kiddle, Steven J; Voyle, Nicola; Dobson, Richard J B

2018-03-29

Ever since the discovery of APOEɛ4 around 25 years ago, researchers have been excited about the potential of a blood test for Alzheimer's disease (AD). Since then researchers have looked for genetic, protein, metabolite, and/or gene expression markers of AD and related phenotypes. However, no blood test for AD is yet being used in the clinical setting. We first review the trends and challenges in AD blood biomarker research, before giving our personal recommendations to help researchers overcome these challenges. While some degree of consistency and replication has been seen across independent studies, several high-profile studies have seemingly failed to replicate. Partly due to academic incentives, there is a reluctance in the field to report predictive ability, to publish negative findings, and to independently replicate the work of others. If this can be addressed, then we will know sooner whether a blood test for AD or related phenotypes with clinical utility can be developed.

Current status and challenges for automotive battery production technologies

Science.gov (United States)

Kwade, Arno; Haselrieder, Wolfgang; Leithoff, Ruben; Modlinger, Armin; Dietrich, Franz; Droeder, Klaus

2018-04-01

Production technology for automotive lithium-ion battery (LIB) cells and packs has improved considerably in the past five years. However, the transfer of developments in materials, cell design and processes from lab scale to production scale remains a challenge due to the large number of consecutive process steps and the significant impact of material properties, electrode compositions and cell designs on processes. This requires an in-depth understanding of the individual production processes and their interactions, and pilot-scale investigations into process parameter selection and prototype cell production. Furthermore, emerging process concepts must be developed at lab and pilot scale that reduce production costs and improve cell performance. Here, we present an introductory summary of the state-of-the-art production technologies for automotive LIBs. We then discuss the key relationships between process, quality and performance, as well as explore the impact of materials and processes on scale and cost. Finally, future developments and innovations that aim to overcome the main challenges are presented.

Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals

DEFF Research Database (Denmark)

Nielsen, Søren Saxmose; Toft, Nils; Gardner, Ian Andrew

2011-01-01

Diagnostic test evaluations (DTEs) for chronic infections are challenging because a protracted incubation period has to be considered in the design of the DTE, and the adverse effects of infection may be widespread and progressive over an animal's entire life. Frequently, the specific purpose......) than originally intended. The objective of this paper is to outline a structured approach to the design and conduct of a DTE for diagnostic tests used for chronic infections in animals, and intended for different purposes. We describe the process from reflections about test purpose and the underlying...... of the test is not formally considered when a test is evaluated. Therefore, the result is often a DTE where test sensitivity and specificity estimates are biased, either because of problems with establishing the true infection status or because the test detects another aspect of the infection (and analyte...

Assessing the Global Development Agenda (Goal 1 in Uganda: The Progress Made and the Challenges that Persist

Directory of Open Access Journals (Sweden)

E. A. Ndaguba

2016-12-01

Full Text Available The international development agenda (2000-2015 that was hailed in Uganda was unsuccessful and powerless in elevating individuals and groups to a place of comfort through the achievement of the MDGs. Hence, according to a survey of the Directorate of Social Protection in 2012, 67% of citizens of Uganda are either highly vulnerable to remaining in poverty or being poor.  This study therefore assesses the gains of the global development agenda (2000 – 2015 in Uganda. The study relies heavily on review papers, secondary dataset and material, and quasi-quantitative method in analyzing the research aim. Results show that ambiguous and unrealistic targets of the MDGs did not take into cognizance the structures, institutions, and interaction of systems and governance issues in Uganda. Despite these, the gains were also shortchanged as a result of drought, flood, and high prices of commodities, due to low farm production in most (rural areas in Uganda. In addition to the drought and the negative effects of climate change, other challenges include deficient access to markets and market place, lack of motorized and non-motorized load-carrying wheel vehicles, lack of capacity and infrastructure, lack of mechanized farming implements, and the lack of access to credit reduced the potency of the achievement of most of its goals. However, significant strides were attempted and the country was able to achieve several targets, which are worth celebrating. The study contends that the realization of the SDGs will only be wishful thinking, if challenges of rural poverty, governance and institution are not put in check. Shared progress and prosperity as acclaimed by the World Bank will never be visible in Uganda.

Status and Future of Lunar Geoscience.

Science.gov (United States)

1986

A review of the status, progress, and future direction of lunar research is presented in this report from the lunar geoscience working group of the National Aeronautics and Space Administration. Information is synthesized and presented in four major sections. These include: (1) an introduction (stating the reasons for lunar study and identifying…

Evolution of Cerebral Atrophy in a Patient with Super Refractory Status Epilepticus Treated with Barbiturate Coma

Directory of Open Access Journals (Sweden)

Christopher R. Newey

2017-01-01

Full Text Available Introduction. Status epilepticus is associated with neuronal breakdown. Radiological sequelae of status epilepticus include diffusion weighted abnormalities and T2/FLAIR cortical hyperintensities corresponding to the epileptogenic cortex. However, progressive generalized cerebral atrophy from status epilepticus is underrecognized and may be related to neuronal death. We present here a case of diffuse cerebral atrophy that developed during the course of super refractory status epilepticus management despite prolonged barbiturate coma. Methods. Case report and review of the literature. Case. A 19-year-old male with a prior history of epilepsy presented with focal clonic seizures. His seizures were refractory to multiple anticonvulsants and eventually required pentobarbital coma for 62 days and midazolam coma for 33 days. Serial brain magnetic resonance imaging (MRI showed development of cerebral atrophy at 31 days after admission to our facility and progression of the atrophy at 136 days after admission. Conclusion. This case highlights the development and progression of generalized cerebral atrophy in super refractory status epilepticus. The cerebral atrophy was noticeable at 31 days after admission at our facility which emphasizes the urgency of definitive treatment in patients who present with super refractory status epilepticus. Further research into direct effects of therapeutic coma is warranted.

Fail or flourish? Cognitive appraisal moderates the effect of solo status on performance.

Science.gov (United States)

White, Judith B

2008-09-01

When everyone in a group shares a common social identity except one individual, the one who is different from the majority has solo status. Solo status increases one's visibility and performance pressure, which may result in stress. Stress has divergent effects on performance, and individuals' response to stressful situations is predicted by their cognitive appraisal (challenge or threat) of the situation. Two experiments test the hypothesis that cognitive appraisal moderates the effect of solo status on performance. Experiment 1 finds that at relatively high appraisal levels (resources exceed demands), solo status improves men's and women's performance; at relatively low appraisal levels, solo status hurts performance. Experiment 2 replicates this effect for solo status based on minimal group assignment. Results suggest that for individuals who feel challenged and not threatened by their work, it may help to be a solo.

Status report on controlled thermonuclear fusion

International Nuclear Information System (INIS)

1990-06-01

The International Fusion Research Council (IFRC), an advisory body to the International Atomic Energy Agency, reports on the current status of fusion; this report updates its 1978 status report. This report contains a General Overview and Executive Summary, and reports on all current approaches to fusion throughout the world; a series of technical reports is to be published elsewhere. This report is timely in that it not only shows progress which has occurred over the past, but interfaces with possible future devices, in particular the International Thermonuclear Experimental Reactor (ITER), whose conceptual design phase is nearing completion. 5 refs, 6 figs

Accomplishments and challenges of the severe accident research

International Nuclear Information System (INIS)

Sehgal, B.R.

2001-01-01

This paper briefly describes the progress of the severe accident research since 1980, in terms of the accomplishments made so far and the challenges that remain. Much has been accomplished: many important safety issues have been resolved and consensus is near on some others. However, some of the previously identified safety issues remain as challenges, while some new ones have arisen due to the shift in focus from containment to vessel integrity. New reactor designs have also created some new challenges. In general, the regulatory demands for new reactor designs are stricter, thereby requiring much greater attention to the safety issues concerned with the containment design of the new large reactors, and to the accident management procedures for mitigating the consequences of a severe accident. We apologize for not providing references to many fine investigations that contributed to the great progress made so far in the severe accident research

Uterine sarcomas-Recent progress and future challenges

International Nuclear Information System (INIS)

Seddon, Beatrice M.; Davda, Reena

2011-01-01

Uterine sarcomas are a group of rare tumours that provide considerable challenges in their treatment. Radiological diagnosis prior to hysterectomy is difficult, with the diagnosis frequently made post-operatively. Current staging systems have been unsatisfactory, although a new FIGO staging system specifically for uterine sarcomas has now been introduced, and may allow better grouping of patients according to expected prognosis. While the mainstay of treatment of early disease is a total abdominal hysterectomy, it is less clear whether routine oophorectomy or lymphadenectomy is necessary. Adjuvant pelvic radiotherapy may improve local tumour control in high risk patients, but is not associated with an overall survival benefit. Similarly there is no good evidence for the routine use of adjuvant chemotherapy. For advanced leiomyosarcoma, newer chemotherapy agents including gemcitabine and docetaxel, and trabectedin, offer some promise, while hormonal therapies appear to be more useful in endometrial stromal sarcoma. Novel targeted agents are now being introduced for sarcomas, and uterine sarcomas, and show some indications of activity. Non-pharmacological treatments, including surgical metastatectomy, radiofrequency ablation, and CyberKnife radiotherapy, are important additions to systemic therapy for advanced metastatic disease.

Beyond metric gravity: Progress on PS-200

International Nuclear Information System (INIS)

Goldman, T.; Brown, R.E.; Camp, J.B.; Darling, T.; Dyer, P.; Holzscheiter, M.H.; Hughes, R.J.; Jarmie, N.; King, N.S.P.; Lizon, D.C.; Nieto, M.M.; Schauer, M.M.M.; Schecker, J.A.; Cornford, S.; Hosea, K.; Kenefick, R.A.; Hoibraaten, S.; Midzor, M.M.; Parry, S.P.; Ristenen, R.A.; Witteborn, F.C.

1993-01-01

The reconciliation of quantum mechanics and gravity on varying distance scales requires changes to General Relativity that may be testable implications. We briefly review the status of tests with matter of the inverse square law and the principle of equivalence, then report on progress on the drift-tube measurement section of PS- 200, the experiment to measure the gravitational acceleration of antiprotons

Micro/Nanofibre Optical Sensors: Challenges and Prospects

Directory of Open Access Journals (Sweden)

Limin Tong

2018-03-01

Full Text Available Micro/nanofibres (MNFs are optical fibres with diameters close to or below the vacuum wavelength of visible or near-infrared light. Due to its wavelength- or sub-wavelength scale diameter and relatively large index contrast between the core and cladding, an MNF can offer engineerable waveguiding properties including optical confinement, fractional evanescent fields and surface intensity, which is very attractive to optical sensing on the micro and nanometer scale. In particular, the waveguided low-loss tightly confined large fractional evanescent fields, enabled by atomic level surface roughness and extraordinary geometric and material uniformity in a glass MNF, is one of its most prominent merits in realizing optical sensing with high sensitivity and great versatility. Meanwhile, the mesoporous matrix and small diameter of a polymer MNF, make it an excellent host fibre for functional materials for fast-response optical sensing. In this tutorial, we first introduce the basics of MNF optics and MNF optical sensors, and review the progress and current status of this field. Then, we discuss challenges and prospects of MNF sensors to some extent, with several clues for future studies. Finally, we conclude with a brief outlook for MNF optical sensors.

Progress in the Gondwanan Carboniferous–Permian palynology ...

Indian Academy of Sciences (India)

The first section describes challenges in the Carboniferous–Permian Gondwanan stratigraphic palynology, and progress in techniques such as presence of the 'rare-marine intervals', and 'radiometric dating' in some Gondwanan successions, e.g., South Africa, Australia and South America, as tools to confidently calibrate ...

Progress and status of neutron radiography and gauging in Europe

International Nuclear Information System (INIS)

Balasko, Marton

1996-01-01

European neutron radiography (NR) stations, applications and main trends of progress are surveyed. NR laboratories installed at research reactors operating in eight countries. DIANE transportable neutron source has been constructed within the framework of EURECA project. High resolution film techniques and video imaging are used in various applications. In several cases NR is combined with other non-destructive methods. The European Neutron Radiography Working Group organizes annual meetings and international projects (COST, INCO Copernicus) to promote personal contacts and scientific cooperation in this field. (author)

Audiovisual quality assessment in communications applications: Current status, trends and challenges

DEFF Research Database (Denmark)

Korhonen, Jari

2010-01-01

Audiovisual quality assessment is one of the major challenges in multimedia communications. Traditionally, algorithm-based (objective) assessment methods have focused primarily on the compression artifacts. However, compression is only one of the numerous factors influencing the perception...... addressed in practical quality metrics is the co-impact of audio and video qualities. This paper provides an overview of the current trends and challenges in objective audiovisual quality assessment, with emphasis on communication applications...

Envisioning future academic library services initiatives, ideas and challenges

CERN Document Server

McKnight, Sue

2010-01-01

There are huge challenges facing the library and information science profession. Librarians need to be 'blended professionals' who can take their professional skills and experience, and adapt them to different business models and strategic challenges. This work intends to stimulate strategic and innovative thinking and questions the status quo.

The Goddard Integral Field Spectrograph at Apache Point Observatory: Current Status and Progress Towards Photon Counting

Science.gov (United States)

McElwain, Michael W.; Grady, Carol A.; Bally, John; Brinkmann, Jonathan V.; Bubeck, James; Gong, Qian; Hilton, George M.; Ketzeback, William F.; Lindler, Don; Llop Sayson, Jorge; Malatesta, Michael A.; Norton, Timothy; Rauscher, Bernard J.; Rothe, Johannes; Straka, Lorrie; Wilkins, Ashlee N.; Wisniewski, John P.; Woodgate, Bruce E.; York, Donald G.

2015-01-01

We present the current status and progress towards photon counting with the Goddard Integral Field Spectrograph (GIFS), a new instrument at the Apache Point Observatory's ARC 3.5m telescope. GIFS is a visible light imager and integral field spectrograph operating from 400-1000 nm over a 2.8' x 2.8' and 14' x 14' field of view, respectively. As an IFS, GIFS obtains over 1000 spectra simultaneously and its data reduction pipeline reconstructs them into an image cube that has 32 x 32 spatial elements and more than 200 spectral channels. The IFS mode can be applied to a wide variety of science programs including exoplanet transit spectroscopy, protostellar jets, the galactic interstellar medium probed by background quasars, Lyman-alpha emission line objects, and spectral imaging of galactic winds. An electron-multiplying CCD (EMCCD) detector enables photon counting in the high spectral resolution mode to be demonstrated at the ARC 3.5m in early 2015. The EMCCD work builds upon successful operational and characterization tests that have been conducted in the IFS laboratory at NASA Goddard. GIFS sets out to demonstrate an IFS photon-counting capability on-sky in preparation for future exoplanet direct imaging missions such as the AFTA-Coronagraph, Exo-C, and ATLAST mission concepts. This work is supported by the NASA APRA program under RTOP 10-APRA10-0103.

The relative economic progress of male foreign workers in Kuwait.

Science.gov (United States)

Al-qudsi, S S; Shah, N M

1991-01-01

"A human capital framework is utilized to examine the economic progress of nine nationality groups of foreign workers [in Kuwait] using data from the 1983 national Labor Survey. The sources of earnings' variations of particular interest to us included different degrees of education and experience transferability, occupational affiliation and ethnic background. In general, the results derived from the analysis suggest that 1) foreign workers achieve a discernible economic progress as their residence lengthens; 2) the rate of economic progress varies depending on worker's education, home and Kuwait-specific experience, occupational status and ethnic background; and 3) about one third of the earnings inequality is due to unexplained factors including discrimination." excerpt

Feasibility of progressive sit-to-stand training among older hospitalized patients

DEFF Research Database (Denmark)

Pedersen, Mette Merete; Petersen, Janne; Bean, Jonathan F

2015-01-01

hospitalization and once following discharge in their own homes. A structured interview including assessment of possible modifiers (cognitive status by the Short Orientation Memory test and mobility by the De Morton Mobility Index) was administered both on admission to the hospital and in the home setting...... was independent of cognitive status. Conclusions. We found a simple progression model for loaded sit-to-stands (STAND) feasible in acutely admitted older medical patients (≥65 yrs), based on our pre-specified criteria for feasibility....... and dose for older patients. Therefore, our aim was to test the feasibility of a progression model for loaded sit-to-stand training among older hospitalized patients. Methods. This is a prospective cohort study conducted as a feasibility study prior to a full-scale trial. We included twenty-four older...

Infrastructures of progress and dispossession

DEFF Research Database (Denmark)

Andersen, Astrid Oberborbeck

2016-01-01

and organizational infrastructural arrangements, it is argued, can open up for understanding how local and beyond-local processes tangle in complex ways and are productive of new subjectivities; how relations are reconfi gured in neoliberal landscapes of progress and dispossession. Such an approach makes evident how...... to reposition small and medium-scale farmers as backward. Th is article analyzes how farmers struggle to fi nd their place within a neoliberal urban ecology where diff erent conceptions of what constitutes progress in contemporary Peru infl uence the landscape. Using an analytical lens that takes material...... and organizational infrastructures and practices into account, and situates these in specifi c historical processes, the article argues that farmers within the urban landscape of Arequipa struggle to reclaim land and water, and reassert a status that they experience to be losing. Such a historical focus on material...

The status of women in academic anesthesiology: a progress report.

Science.gov (United States)

Wong, Cynthia A; Stock, Marie Christine

2008-07-01

The number of women in medicine has increased steadily in the last half century. In this study, we reassessed the status of women in academic anesthesiology departments in the United States in 2006. Medical student, resident, and faculty rank gender data were obtained from the Association of American Medical Colleges. Data regarding the make-up and gender of anesthesia subspecialty society leadership, the editorial boards of Anesthesia & Analgesia and Anesthesiology, the awardees of anesthesia research grants, American Board of Anesthesiology examiners, and department chairs were obtained from websites, organization management personnel, and the Wood Library-Museum of Anesthesiology. Anesthesiology data were compared with composite data from medical school departments in other clinical specialties and to data from previous years, beginning in 1985. The percentage of medical school graduates, anesthesiology residents, and anesthesiology faculty members who are women has increased since 1985; however, the rate of increase in the percentage of women is significantly faster for medical school graduates compared with anesthesiology residents (P research grants awarded to women has not changed over several decades. The status of women in academic anesthesiology in the first decade of the millennium has, by some measures, advanced compared with 20 yr ago. However, by other measures, there has been no change. The task ahead is to identify factors that discourage qualified women medical students, residents, and junior faculty members from pursuing careers in academic anesthesiology and advancing in academic rank.

EXAMINING ADULT’S IDENTITY STATUSES: ADAPTIVE VS. MALADAPTIVE DIMENSION

Directory of Open Access Journals (Sweden)

Maia Mestvirishvili

2014-12-01

Full Text Available To achieve the status of ego identity remains the most important challenge for the adolescence period and consequently is a challenge for developmental psychologists too. The vast majority of studies focus on understanding the dynamics of ego identity development, however, factors that cause different path of development remained unclear. This study aims at tracking the paths, which differentiate ego statuses from finding psychosocial factors contributing to ego identity achievement. For this purpose the relationships between four identity statuses - achievement, exploration, moratorium and foreclosure and number of psychosocial variables such as attachment style, self-esteem and perfectionism have been examined. 386 school teenagers aged 14-17 (M = 15.48 filled a set of questionnaires comprised of four instruments: The Ego Identity Process Questionnaire (EIPQ, The Measure of Attachment Qualities (MAQ, The Perfectionism Inventory (PI and Adult Sources of Self-Esteem Inventory (ASSEI. Discriminant analysis revealed two basic dimensions (adaptive and maladaptive, which are capable to depict the difference between ego identity statuses. The first discriminant function of ego identity status is primarily defined by conscientious perfectionism and secured attachment; whereas, the second discriminant function consists of avoidance attachment, self-evaluative perfectionism and ambivalent attachment styles.

WBP/SIGAME the Brazilian BIG-GT demonstration project actual status and perspectives

International Nuclear Information System (INIS)

Carpentier, E.; Silva, A.

1998-01-01

Located in the tropics, with the sun shining all year round, and with its vast territory, Brazil may be regarded as having all the basic conditions to develop a modern Biomass for Electricity industry. Those characteristics together with: (a) the necessity of developing new energy resources for electricity production, in the northeast of the country; (b) the results of studies made by various entities, including CHESF; (c) the progress achieved by the BIG-GT technology; (d) the organisation of the Global Environment Facility (GEF); (e) and the support of the Brazilian government, through the Ministry of Science and Technology (MCT), provided the unique opportunity for the implementation of a commercial demonstration of that technology in Brazil. This paper describes the idea, scope, challenges, lessons, and actual status of development of the WBP/SIGAME project. It also highlights some institutional issues, budget figures, and energy prices. (author)

Progress and challenges associated with digitizing and serving up Hawaii's geothermal data

Science.gov (United States)

Thomas, D. M.; Lautze, N. C.; Abdullah, M.

2012-12-01

This presentation will report on the status of our effort to digitize and serve up Hawaii's geothermal information, an undertaking that commenced in 2011 and will continue through at least 2013. This work is part of national project that is funded by the Department of Energy and managed by the Arizona State Geology Survey (AZGS). The data submitted to AZGS is being entered into the National Geothermal Data System (see http://www.stategeothermaldata.org/overview). We are also planning to host the information locally. Main facets of this project are to: - digitize and generate metadata for non-published geothermal documents relevant to the State of Hawaii - digitize ~100 years of paper records relevant to well permitting and water resources development and serve up information on the ~4500 water wells in the state - digitize, organize, and serve up information on research and geothermal exploratory drilling conducted from the 1980s to the present. - work with AZGS and OneGeology to contribute a geologic map for Hawaii that integrates geologic and geothermal resource data. By December 2012, we anticipate that the majority of the digitization will be complete, the geologic map will be approved, and that over 1000 documents will be hosted online through the University of Hawaii's library system (in the "Geothermal Collection" within the "Scholar Space" repository, see http://scholarspace.manoa.hawaii.edu/handle/10125/21320). Developing a 'user-friendly' web interface for the water well and drilling data will be a main task in the coming year. Challenges we have faced and anticipate include: 1) ensuring that no personally identifiable information (e.g. SSN, private telephone numbers, bank or credit account) is contained in the geothermal documents and well files; 2) Homeland Security regulations regarding release of information on critical infrastructure related to municipal water supply systems; 3) maintenance of the well database as future well data are developed with

Dryland climate change: Recent progress and challenges

Science.gov (United States)

Huang, J.; Li, Y.; Fu, C.; Chen, F.; Fu, Q.; Dai, A.; Shinoda, M.; Ma, Z.; Guo, W.; Li, Z.; Zhang, L.; Liu, Y.; Yu, H.; He, Y.; Xie, Y.; Guan, X.; Ji, M.; Lin, L.; Wang, S.; Yan, H.; Wang, G.

2017-09-01

Drylands are home to more than 38% of the world's population and are one of the most sensitive areas to climate change and human activities. This review describes recent progress in dryland climate change research. Recent findings indicate that the long-term trend of the aridity index (AI) is mainly attributable to increased greenhouse gas emissions, while anthropogenic aerosols exert small effects but alter its attributions. Atmosphere-land interactions determine the intensity of regional response. The largest warming during the last 100 years was observed over drylands and accounted for more than half of the continental warming. The global pattern and interdecadal variability of aridity changes are modulated by oceanic oscillations. The different phases of those oceanic oscillations induce significant changes in land-sea and north-south thermal contrasts, which affect the intensity of the westerlies and planetary waves and the blocking frequency, thereby altering global changes in temperature and precipitation. During 1948-2008, the drylands in the Americas became wetter due to enhanced westerlies, whereas the drylands in the Eastern Hemisphere became drier because of the weakened East Asian summer monsoon. Drylands as defined by the AI have expanded over the last 60 years and are projected to expand in the 21st century. The largest expansion of drylands has occurred in semiarid regions since the early 1960s. Dryland expansion will lead to reduced carbon sequestration and enhanced regional warming. The increasing aridity, enhanced warming, and rapidly growing population will exacerbate the risk of land degradation and desertification in the near future in developing countries.

Combined high-field intraoperative magnetic resonance imaging and endoscopy increase extent of resection and progression-free survival for pituitary adenomas

Science.gov (United States)

Sylvester, Peter T.; Evans, John A.; Zipfel, Gregory J.; Chole, Richard A.; Uppaluri, Ravindra; Haughey, Bruce H.; Getz, Anne E.; Silverstein, Julie; Rich, Keith M.; Kim, Albert H.; Dacey, Ralph G.

2014-01-01

Purpose The clinical benefit of combined intraoperative magnetic resonance imaging (iMRI) and endoscopy for transsphenoidal pituitary adenoma resection has not been completely characterized. This study assessed the impact of microscopy, endoscopy, and/or iMRI on progression-free survival, extent of resection status (gross-, near-, and subtotal resection), and operative complications. Methods Retrospective analyses were performed on 446 transsphenoidal pituitary adenoma surgeries at a single institution between 1998 and 2012. Multivariate analyses were used to control for baseline characteristics, differences during extent of resection status, and progression-free survival analysis. Results Additional surgery was performed after iMRI in 56/156 cases (35.9 %), which led to increased extent of resection status in 15/156 cases (9.6 %). Multivariate ordinal logistic regression revealed no increase in extent of resection status following iMRI or endoscopy alone; however, combining these modalities increased extent of resection status (odds ratio 2.05, 95 % CI 1.21–3.46) compared to conventional transsphenoidal microsurgery. Multivariate Cox regression revealed that reduced extent of resection status shortened progression-free survival for near- versus gross-total resection [hazard ratio (HR) 2.87, 95 % CI 1.24–6.65] and sub- versus near-total resection (HR 2.10; 95 % CI 1.00–4.40). Complication comparisons between microscopy, endoscopy, and iMRI revealed increased perioperative deaths for endoscopy versus microscopy (4/209 and 0/237, respectively), but this difference was non-significant considering multiple post hoc comparisons (Fisher exact, p = 0.24). Conclusions Combined use of endoscopy and iMRI increased pituitary adenoma extent of resection status compared to conventional transsphenoidal microsurgery, and increased extent of resection status was associated with longer progression-free survival. Treatment modality combination did not significantly impact

Progress and challenges in the development of a cell-based therapy for hemophilia A.

Science.gov (United States)

Fomin, M E; Togarrati, P P; Muench, M O

2014-12-01

Hemophilia A results from an insufficiency of factor VIII (FVIII). Although replacement therapy with plasma-derived or recombinant FVIII is a life-saving therapy for hemophilia A patients, such therapy is a life-long treatment rather than a cure for the disease. In this review, we discuss the possibilities, progress, and challenges that remain in the development of a cell-based cure for hemophilia A. The success of cell therapy depends on the type and availability of donor cells, the age of the host and method of transplantation, and the levels of engraftment and production of FVIII by the graft. Early therapy, possibly even prenatal transplantation, may yield the highest levels of engraftment by avoiding immunological rejection of the graft. Potential cell sources of FVIII include a specialized subset of endothelial cells known as liver sinusoidal endothelial cells (LSECs) present in the adult and fetal liver, or patient-specific endothelial cells derived from induced pluripotent stem cells that have undergone gene editing to produce FVIII. Achieving sufficient engraftment of transplanted LSECs is one of the obstacles to successful cell therapy for hemophilia A. We discuss recent results from transplants performed in animals that show production of functional and clinically relevant levels of FVIII obtained from donor LSECs. Hence, the possibility of treating hemophilia A can be envisioned through persistent production of FVIII from transplanted donor cells derived from a number of potential cell sources or through creation of donor endothelial cells from patient-specific induced pluripotent stem cells. © 2014 International Society on Thrombosis and Haemostasis.

Progress and challenges in the development of a cell-based therapy for hemophilia A

Science.gov (United States)

Fomin, Marina E.; Togarrati, Padma Priya; Muench, Marcus O.

2015-01-01

Hemophilia A results from an insufficiency of factor VIII (FVIII). Although replacement therapy with plasma-derived or recombinant FVIII is a life-saving therapy for hemophilia A patients, such therapy is a life-long treatment rather than a cure for the disease. In this review we discuss the possibilities, progress and challenges that remain in the development of a cell-based cure for hemophilia A. The success of cell therapy depends on the type and availability of donor cells, the age of the host and method of transplantation, and the levels of engraftment and production of FVIII by the graft. Early therapy, possibly even prenatal transplantation, may yield the highest levels of engraftment by avoiding immunological rejection of the graft. Potential cell sources of FVIII include a specialized subset of endothelial cells known as liver sinusoidal endothelial cells (LSECs) present in the adult and fetal liver, or patient-specific endothelial cells derived from induced pluripotent stem cells (iPSCs) that have undergone gene editing to produce FVIII. Achieving sufficient engraftment of transplanted LSECs is one of the obstacles to successful cell therapy for hemophilia A. We discuss recent results from transplants performed in animals that show production of functional and clinically relevant levels of FVIII obtained from donor LSECs. Hence, the possibility of treating hemophilia A can be envisioned through persistent production of FVIII from transplanted donor cells derived from a number of potential cell sources or through creation of donor endothelial cells from patient-specific iPSCs. PMID:25297648

Technological challenges in thermal plasma production

International Nuclear Information System (INIS)

Ramakrishnan, S.

1995-01-01

Thermal plasmas, generated by electric arc discharges, are used in a variety of industrial applications. The electric arc is a constricted electrical discharge with a high temperature in the range 6000-25,000 K. These characteristics are useful in plasma cutting, spraying, welding and specific areas of material processing. The thermal plasma technology is an enabling process technology and its status in the market depends upon its advantages over competing technologies. A few technological challenges to enhance the status of plasma technology are to improve the utilisation of the unique characteristics of the electric arc and to provide enhanced control of the process. In particular, new solutions are required for increasing the plasma-material interaction, controlling the electrode roots and controlling the thermal power generated by the arcing process. In this paper, the advantages of plasma technology, its constraints and future challenges for technology developments are highlighted. 36 refs., 14 figs

Progress and status of the integral fast reactor (IFR) development program

International Nuclear Information System (INIS)

Chang, Y.I.

1992-01-01

This paper discusses the Integral Fast Reactor (IFR) development program, in which the entire reactor system - reactor, fuel cycle, and waste process is being developed and optimized at the same time as a single integral entity. Detailed discussions on the present status of the IFR technology development activities in the areas of fuels, pyroprocessing, safety, core design, and fuel cycle demonstration are also presented

Taking Action on Air Pollution Control in the Beijing-Tianjin-Hebei (BTH) Region: Progress, Challenges and Opportunities

Science.gov (United States)

Wang, Li; Zhang, Fengying; Pilot, Eva; Yu, Jie; Holdaway, Jennifer; Yang, Linsheng; Li, Yonghua; Wang, Wuyi; Vardoulakis, Sotiris; Krafft, Thomas

2018-01-01

Due to rapid urbanization, industrialization and motorization, a large number of Chinese cities are affected by heavy air pollution. In order to explore progress, remaining challenges, and sustainability of air pollution control in the Beijing-Tianjin-Hebei (BTH) region after 2013, a mixed method analysis was undertaken. The quantitative analysis comprised an overview of air quality management in the BTH region. Semi-structured expert interviews were conducted with 12 stakeholders from various levels of government and research institutions who played substantial roles either in decision-making or in research and advising on air pollution control in the BTH region. The results indicated that with the stringent air pollution control policies, the air quality in BTH meets the targets of the Air Pollution Prevention and Control Action Plan. However, improvements vary across the region and for different pollutants. Although implementation has been decisive and was at least in parts effectively enforced, significant challenges remained with regard to industrial and traffic emission control, and national air quality limits continued to be significantly exceeded and competing development interests remained mainly unsolved. There were also concerns about the sustainability of the current air pollution control measures especially for industries due to the top-down enforcement, and the associated large burden of social cost including unemployment and social inequity resulting industrial restructuring. Better mechanisms for ensuring cross-sectoral coordination and for improved central-local government communication were suggested. Further suggestions were provided to improve the conceptual design and effective implementation of respective air pollution control strategies in BTH. Our study highlights some of the major hurdles that need to be addressed to succeed with a comprehensive air pollution control management for the Chinese mega-urban agglomerations. PMID:29425189

Taking Action on Air Pollution Control in the Beijing-Tianjin-Hebei (BTH) Region: Progress, Challenges and Opportunities.

Science.gov (United States)

Wang, Li; Zhang, Fengying; Pilot, Eva; Yu, Jie; Nie, Chengjing; Holdaway, Jennifer; Yang, Linsheng; Li, Yonghua; Wang, Wuyi; Vardoulakis, Sotiris; Krafft, Thomas

2018-02-09

Due to rapid urbanization, industrialization and motorization, a large number of Chinese cities are affected by heavy air pollution. In order to explore progress, remaining challenges, and sustainability of air pollution control in the Beijing-Tianjin-Hebei (BTH) region after 2013, a mixed method analysis was undertaken. The quantitative analysis comprised an overview of air quality management in the BTH region. Semi-structured expert interviews were conducted with 12 stakeholders from various levels of government and research institutions who played substantial roles either in decision-making or in research and advising on air pollution control in the BTH region. The results indicated that with the stringent air pollution control policies, the air quality in BTH meets the targets of the Air Pollution Prevention and Control Action Plan. However, improvements vary across the region and for different pollutants. Although implementation has been decisive and was at least in parts effectively enforced, significant challenges remained with regard to industrial and traffic emission control, and national air quality limits continued to be significantly exceeded and competing development interests remained mainly unsolved. There were also concerns about the sustainability of the current air pollution control measures especially for industries due to the top-down enforcement, and the associated large burden of social cost including unemployment and social inequity resulting industrial restructuring. Better mechanisms for ensuring cross-sectoral coordination and for improved central-local government communication were suggested. Further suggestions were provided to improve the conceptual design and effective implementation of respective air pollution control strategies in BTH. Our study highlights some of the major hurdles that need to be addressed to succeed with a comprehensive air pollution control management for the Chinese mega-urban agglomerations.

Taking Action on Air Pollution Control in the Beijing-Tianjin-Hebei (BTH Region: Progress, Challenges and Opportunities

Directory of Open Access Journals (Sweden)

Li Wang

2018-02-01

Full Text Available Due to rapid urbanization, industrialization and motorization, a large number of Chinese cities are affected by heavy air pollution. In order to explore progress, remaining challenges, and sustainability of air pollution control in the Beijing-Tianjin-Hebei (BTH region after 2013, a mixed method analysis was undertaken. The quantitative analysis comprised an overview of air quality management in the BTH region. Semi-structured expert interviews were conducted with 12 stakeholders from various levels of government and research institutions who played substantial roles either in decision-making or in research and advising on air pollution control in the BTH region. The results indicated that with the stringent air pollution control policies, the air quality in BTH meets the targets of the Air Pollution Prevention and Control Action Plan. However, improvements vary across the region and for different pollutants. Although implementation has been decisive and was at least in parts effectively enforced, significant challenges remained with regard to industrial and traffic emission control, and national air quality limits continued to be significantly exceeded and competing development interests remained mainly unsolved. There were also concerns about the sustainability of the current air pollution control measures especially for industries due to the top-down enforcement, and the associated large burden of social cost including unemployment and social inequity resulting industrial restructuring. Better mechanisms for ensuring cross-sectoral coordination and for improved central-local government communication were suggested. Further suggestions were provided to improve the conceptual design and effective implementation of respective air pollution control strategies in BTH. Our study highlights some of the major hurdles that need to be addressed to succeed with a comprehensive air pollution control management for the Chinese mega-urban agglomerations.

Data Modeling Challenges of Advanced Interoperability.

Science.gov (United States)

Blobel, Bernd; Oemig, Frank; Ruotsalainen, Pekka

2018-01-01

Progressive health paradigms, involving many different disciplines and combining multiple policy domains, requires advanced interoperability solutions. This results in special challenges for modeling health systems. The paper discusses classification systems for data models and enterprise business architectures and compares them with the ISO Reference Architecture. On that basis, existing definitions, specifications and standards of data models for interoperability are evaluated and their limitations are discussed. Amendments to correctly use those models and to better meet the aforementioned challenges are offered.

Self-Efficacy, Achievement Motivation, and Academic Progress of Students with Learning Disabilities: A Comparison with Typical Students

Directory of Open Access Journals (Sweden)

Sepideh Seyed

2017-03-01

Full Text Available Introduction Many factors including self-efficacy and achievement motivation can affect children’s academic progress. Studies have shown that socioeconomic status can affect people’s life, education, and vocation. However, not many studies looked at the relations between the intrinsic factors and socioeconomic status, and between these 2 categories and students’ academic progress in children with learning disabilities. Thus, the present study aimed at examining self-efficacy, achievement motivation, and academic progress of students with learning disabilities compared with typical students and looking for any possible relation between these variables and socioeconomic status (parental education and occupation. Methods This was a cross sectional study, which included 34 students with learning disabilities and 32 typical students matched on age, gender, and school grade. The participants answered Sherer et al.’s self-efficacy scale (1982 and Herman’s achievement motivation questionnaire (2000. Students’ academic progress was evaluated based on the descriptive scores in the first semester. Findings Scores of children with learning disabilities in self-efficacy, achievement motivation, and academic progress were significantly lower than those of matched controls (P<0.0001. Results revealed moderate positive correlations between academic progress and different levels of self-efficacy (rs = 0.441, P<0.0001, N = 66; and between academic progress and achievement motivation (rs = 0.645, P<0.0001, N = 66. The results of the correlation analysis demonstrated weak to moderate positive correlations between academic progress and parental education (rs = 0.39, P = 0.001, academic progress and father’s occupation (rs = 0.323, P = 0.008, achievement motivation and parental education (rs = .34, p = 0.009, N = 66, and finally achievement motivation and father’s occupation (rs = 0.285, P = 0.02, N = 66. Conclusions Lower levels of self-efficacy and

Climate Reanalysis: Progress and Future Prospects

Science.gov (United States)

Gelaro, Ron

2018-01-01

Reanalysis is the process whereby an unchanging data assimilation system is used to provide a consistent reprocessing of observations, typically spanning an extended segment of the historical data record. The process relies on an underlying model to combine often-disparate observations in a physically consistent manner, enabling production of gridded data sets for a broad range of applications including the study of historical weather events, preparation of climatologies, business sector development and, more recently, climate monitoring. Over the last few decades, several generations of reanalyses of the global atmosphere have been produced by various operational and research centers, focusing more or less on the period of regular conventional and satellite observations beginning in the mid to late twentieth century. There have also been successful efforts to extend atmospheric reanalyses back to the late nineteenth and early twentieth centuries, using mostly surface observations. Much progress has resulted from (and contributed to) advancements in numerical weather prediction, especially improved models and data assimilation techniques, increased computing capacity, the availability of new observation types and efforts to recover and improve the quality of historical ones. The recent extension of forecast systems that allow integrated modeling of meteorological, oceanic, land surface, and chemical variables provide the basic elements for coupled data assimilation. This has opened the door to the development of a new generation of coupled reanalyses of the Earth system, or integrated Earth system analyses (IESA). Evidence so far suggests that this approach can improve the analysis of currently uncoupled components of the Earth system, especially at their interface, and lead to increased predictability. However, extensive analysis coupling as envisioned for IESA, while progressing, still presents significant challenges. These include model biases that can be

Role of p53 status in radiation sensitivity and cell cycle progression

International Nuclear Information System (INIS)

Zellars, Richard C.; Loney, Tania; Schott, Ann F.; Davis, Mary A.; Maybaum, Jonathan; Clarke, Michael F.; Lawrence, Theodore S.

1995-01-01

Purpose: Although p53 function plays a major role in G1 arrest after radiation, the influence of p53 status on progress through other phases of the cell cycle and on radiation sensitivity of human tumors is less clear. We investigated these issues using cells with a conditional expression system for wild type p53. Methods: A temperature sensitive murine wild type p53 plasmid was used (Ginsberg D, et al: Mol. Cell.Biol . 11:582, 1991). At the permissive temperature (32 deg. C), this plasmid produces a protein which assumes a conformation that exhibits wild type p53 function. However, when cells are cultured at 38 deg. C, this protein assumes an inactive conformation. HT29 human colon cancer cells (which are p53 mutant) were transduced with this plasmid (designated PEP A and PEP G cells) or a control vector (designated CCH1 cells) using electroporation and Geneticin selection. The presence of murine p53 transcript in the PEP cells was confirmed by Northern analysis. Results: Cells were cultured under 3 conditions: 1) 38 deg. C at all times; 2) 32 deg. C for 24 hours prior to irradiation and 3) 32 deg. C for 24 hours after irradiation. We found that culturing under permissive temperatures produced a small decrease in surviving fraction in the PEP clones (0.61 ± 0.10 and 0.64 ± 0.07, for PEP A and G, respectively) but not the CCH1 controls (1.14 ± 0.15). PEP cells tended to be more radiosensitive than CCH1 cells (even under non-permissive conditions) and demonstrated a trend towards increased radiosensitivity under both Conditions 2 and 3. In addition, flow cytometry revealed that a 24 hour exposure to permissive conditions increased the fraction of cells in G1 slightly and in G2/M substantially. S phase was almost absent. Conclusion: Restoration of p53 function in HT29 human colon cancer cells using this temperature sensitive system produced increased cytotoxicity and radiation sensitivity as well as cell cycle redistribution. It will be important to assess the

Model-based setup assistant for progressive tools

Science.gov (United States)

Springer, Robert; Gräler, Manuel; Homberg, Werner; Henke, Christian; Trächtler, Ansgar

2018-05-01

In the field of production systems, globalization and technological progress lead to increasing requirements regarding part quality, delivery time and costs. Hence, today's production is challenged much more than a few years ago: it has to be very flexible and produce economically small batch sizes to satisfy consumer's demands and avoid unnecessary stock. Furthermore, a trend towards increasing functional integration continues to lead to an ongoing miniaturization of sheet metal components. In the industry of electric connectivity for example, the miniaturized connectors are manufactured by progressive tools, which are usually used for very large batches. These tools are installed in mechanical presses and then set up by a technician, who has to manually adjust a wide range of punch-bending operations. Disturbances like material thickness, temperatures, lubrication or tool wear complicate the setup procedure. In prospect of the increasing demand of production flexibility, this time-consuming process has to be handled more and more often. In this paper, a new approach for a model-based setup assistant is proposed as a solution, which is exemplarily applied in combination with a progressive tool. First, progressive tools, more specifically, their setup process is described and based on that, the challenges are pointed out. As a result, a systematic process to set up the machines is introduced. Following, the process is investigated with an FE-Analysis regarding the effects of the disturbances. In the next step, design of experiments is used to systematically develop a regression model of the system's behaviour. This model is integrated within an optimization in order to calculate optimal machine parameters and the following necessary adjustment of the progressive tool due to the disturbances. Finally, the assistant is tested in a production environment and the results are discussed.

Behavioural sleep treatments and night time crying in infants: challenging the status quo.

Science.gov (United States)

Blunden, Sarah L; Thompson, Kirrilly R; Dawson, Drew

2011-10-01

In Australia, as in many Westernised industrialised nations, the majority of families encourage infants to sleep alone or 'solo' from an early age. Sleeping solo can increase night time crying, which in turn disrupts sleep for both parent and infant. Night time waking and crying are frequently culturally constructed as behavioural sleep 'problems'. The pursuit of solo sleeping is thus achieved through 'behavioural sleep treatments' that teach an infant to sleep alone. Some behavioural extinction treatments necessitate a parent leaving an infant to cry for extended periods unattended, a practice reportedly difficult for parents. Despite parent's anxieties, and the potential (though little studied) stress to the infant, the pursuit of those behavioural sleep treatments are advocated by many psychologists and clinicians as acceptable and necessary interventions. This paper questions this necessity and critically reviews and debates these methods from biological, anthropological and cultural perspectives. Specifically, it considers Foucaultian, Leidloffian, attachment and behavioural perspectives. The central debate in this paper is if and why an infant's nocturnal cries should be ignored. It challenges the aetiology and acceptance of the status quo in the hope of revisiting the underlying belief that these methods are necessary. In doing so, the paper theorises the ways in which current sleep training techniques do or do not satisfy the needs of infants and their parents and questions the extent to which they can be reconciled. The paper posits an agenda for further research in the area that may facilitate the reconciliation of the needs of parents and those of their infants. Copyright © 2010 Elsevier Ltd. All rights reserved.

The challenge of the future. Technical progress and ecological perspectives

International Nuclear Information System (INIS)

Jischa, M.F.

1993-01-01

The book introduces readers into the interrelated global problems population dynamics, energy supply, imminent climate catastrophe, environmetal pollution, finite resources and the conflict between the North and South. It encourages probing more deeply into the technical challenges of the future. The author demonstrates why economic and technical issues will soon be outstripped by questions of the environmental, human and social compatibility of new technologies. (orig./UA) [de

Occupational Exposure to HDI: Progress and Challenges in Biomarker Analysis

OpenAIRE

Flack, Sheila L.; Ball, Louise M.; Nylander-French, Leena A.

2010-01-01

1,6-hexamethylene diisocyanate (HDI) is extensively used in the automotive repair industry and is a commonly reported cause of occupational asthma in industrialized populations. However, the exact pathological mechanism remains uncertain. Characterization and quantification of biomarkers resulting from HDI exposure can fill important knowledge gaps between exposure, susceptibility, and the rise of immunological reactions and sensitization leading to asthma. Here, we discuss existing challenge...

Renewables 2013. Global Status Report

Energy Technology Data Exchange (ETDEWEB)

Sawin, J. L. [and others

2013-07-01

Renewable energy markets, industries, and policy frameworks have evolved rapidly in recent years. The Renewables Global Status Report provides a comprehensive and timely overview of renewable energy market, industry, investment, and policy developments worldwide. It relies on the most recent data available, provided by many contributors and researchers from around the world, all of which is brought together by a multi-disciplinary authoring team. The report covers recent developments, current status, and key trends; by design, it does not provide analysis or forecasts. This latest Renewables Global Status Report saw: a shift in investment patterns that led to a global decrease in clean energy investment; continuing growth in installed capacity due to significant technology cost reductions and increased investment in developing countries; renewables progressively supplementing established electricity systems, demonstrating that the implementation of suitable policies can enable the successful integration of higher shares of variable renewables; and the emergence of integrated policy approaches that link energy efficiency measures with the implementation of renewable energy technologies.

Nuclear safeguards research. Program status report. Progress report, September--December 1975

International Nuclear Information System (INIS)

1976-04-01

This report presents the status of the Nondestructive Assay R and D program of the LASL Nuclear Safeguards Research Group, R-1, covering the period September-December 1975. It covers: holdup measurements at the Kerr-McGee Pu facility at Crescent, Okla.; calculations for Random Driver; instrument development and measurement controls; ERDA nondestructive assay training program; and in-plant dynamic materials control (DYMAC) program. 22 figures, 5 tables

The Status of Women in Physics in the U.S.: Progress and New Actions

Science.gov (United States)

Xie, Aihua

2005-10-01

The 2005 Chair of the American Physical Society Committee on the Status of Women in Physics describes the committee's recent activities to recognize distinguished women physicists, improve the climate for women in physics, and provide leadership training for women in physics. The committee's response to the Harvard University president's suggestion of innate gender differences as regards women's representation in math and science is also discussed, as well as some encouraging developments in the status of women in physics in the U.S.

Current status of chirality in agrochemicals.

Science.gov (United States)

Jeschke, Peter

2018-04-27

The agrochemical industry is continuously searching for new pesticides to develop products with optimal efficacy, lower application rates in the field, increased selectivity, favorable toxicological and environmental safety, enhanced user friendliness and better economic viability. One strategy to achieve these ambitious goals makes use of the unique properties of molecules containing asymmetric centers. In the past, many natural products and their congeners have been a source of inspiration for designing new active ingredients, and the molecular structure of the resulting molecules have become increasingly complex. 30% contain fragments with asymmetric centers. However, despite the enormous progress that has been made in catalytic asymmetric processes over the last decade, only few agrochemicals are produced in enantiomerically pure or enriched form on an industrial scale. Since 2007, around 43% of the 44 launched products (insecticides, acaricides, fungicides, nematicides, and herbicides) contain one or more asymmetric centers in the molecule (≈ 47 %) and most of them were launched as racemic mixtures of enantiomers or diastereomers. This review gives an overview of the current status of chiral agrochemicals launched over the past 10 years and describes the inherently connected challenges of modern agricultural chemistry by managing important aspects resulting from stereochemistry of these innovative products. This article is protected by copyright. All rights reserved.

IVS: Current Status and Future Plans

Science.gov (United States)

Behrend, D.; Nothnagel, A.; Petrachenko, W. T.; Tuccari, G.

2016-12-01

The International VLBI Service for Geodesy and Astrometry (IVS) is a globally operating service that coordinates and performs Very Long Baseline Interferometry (VLBI) activities through its constituent components. The VLBI activities are associated with the creation, provision, dissemination, and archiving of relevant VLBI data and products. The products mostly pertain to the determination of the celestial and terrestrial reference frames, the Earth orientation parameters (EOP), atmospheric parameters as well as other ancillary parameters. The IVS observational network currently consists of about 40 radio telescopes worldwide. Subsets of these telescopes (8-12 stations) participate in 24-hour observing sessions that are run several times per week and in 1-hour intensive sessions for UT1 determination every day. The current VLBI network was developed mainly in the 1970s and 1980s. A number of factors, including aging infrastructure and demanding new scientific requirements, started to challenge its future sustainability and relevance. In response, the IVS and other groups developed and started implementing the next generation VLBI system, called VGOS (VLBI Global Observing System), at existing and new sites. The VGOS network is expected to reach maturity in the early 2020s. We describe the current status, progress, and anticipated prospects of geodetic/astrometric VLBI and the IVS.

Plutonium Reclamation Facility incident response project progress report

Energy Technology Data Exchange (ETDEWEB)

Austin, B.A.

1997-11-25

This report provides status of Hanford activities in response to process deficiencies highlighted during and in response to the May 14, 1997, explosion at the Plutonium Reclamation Facility. This report provides specific response to the August 4, 1997, memorandum from the Secretary which requested a progress report, in 120 days, on activities associated with reassessing the known and evaluating new vulnerabilities (chemical and radiological) at facilities that have been shut down, are in standby, are being deactivated or have otherwise changed their conventional mode of operation in the last several years. In addition, this report is intended to provide status on emergency response corrective activities as requested in the memorandum from the Secretary on August 28, 1997. Status is also included for actions requested in the second August 28, 1997, memorandum from the Secretary, regarding timely notification of emergencies.

Plutonium Reclamation Facility incident response project progress report

International Nuclear Information System (INIS)

Austin, B.A.

1997-01-01

This report provides status of Hanford activities in response to process deficiencies highlighted during and in response to the May 14, 1997, explosion at the Plutonium Reclamation Facility. This report provides specific response to the August 4, 1997, memorandum from the Secretary which requested a progress report, in 120 days, on activities associated with reassessing the known and evaluating new vulnerabilities (chemical and radiological) at facilities that have been shut down, are in standby, are being deactivated or have otherwise changed their conventional mode of operation in the last several years. In addition, this report is intended to provide status on emergency response corrective activities as requested in the memorandum from the Secretary on August 28, 1997. Status is also included for actions requested in the second August 28, 1997, memorandum from the Secretary, regarding timely notification of emergencies

The community's research and development programme on decommissioning of nuclear installations. Fourth annual progress report 1988

International Nuclear Information System (INIS)

Anon.

1989-01-01

This is the fourth annual progress report on the European Community's programme (1984-88) of research on the decommissioning of nuclear installations. It shows the status of the programme at 31 December 1988. The fourth progress report describes the objectives, scope and work programme of the 72 research contracts concluded, as well as the progress of work achieved and the results obtained in 1988

The Community's research and development programme on decommissioning of nuclear installations. Third annual progress report 1987

International Nuclear Information System (INIS)

1988-01-01

This is the third annual progress report of the European Community's programme (1984-88) of research on the decommissioning of nuclear installations. It shows the status of the programme on 31 December 1987. The third progress report describes the objectives, scope and work programme of the 69 research contracts concluded, as well as the progress of work achieved and the results obtained in 1987

Uranium Mill Tailings Remedial Action Program. Annual status report

International Nuclear Information System (INIS)

1982-12-01

Progress made during FY 1982, present status, and plans for FY 1983 are described for the following programs: radiological surveys and inclusion of vicinity properties; establishment of cooperative agreements; promulgation of standards for remedial action; acquisition of lands and materials; reprocessing of residual radioactive materials; National Environmental Policy Act (NEPA) documentation; program planning; technology development; remedial action; public participation; other federal agency activities; state and Indian tribe activities; and status of designated sites. Program funding is given

Current status, questions and challenges of transcatheter uterine artery embolization for the treatment of uterine fibroids

International Nuclear Information System (INIS)

Chen Xiaoming; Luo Pengfei

2006-01-01

Current status, questions and challenges of transcatheter uterine artery embolization (UAE) in the treatment of uterine fibroids were summarized and analysed. It has been proved that UAE presents a good effectiveness in controlling the symptoms and shrinkage of fibroid and uterine volumes during follow-up of 4 to 6.9 years domestically and abroad, but relapse of the fibroid may however occur in 2 years or longer after UAE. Generally speaking, UAE is safe in the treatment of uterine fibroids but has a possibility of serious complications. UAE has no damage on normal uterine tissues but may affect pregnancy and delivery of patients significantly later on the cause of hypoxia and inertia of uterus. UAE may cause amenorrhea in the minority of women with ovarian failure and endometrium atrophy. The current questions are how to improve long-term efficiency to reduce relapse of tumor and to insure the safety of UAE. It is our further task to exploit more new effective and safe embolic agents by using animal and clinical study on the basic knowledge of pathology, pharmacology, biochemistry, endocrinology and molecular biology. (authors)

Chronic cerebrospinal vascular insufficiency is not associated with HLA DRB1*1501 status in multiple sclerosis patients.

Directory of Open Access Journals (Sweden)

Bianca Weinstock-Guttman

Full Text Available BACKGROUND: Chronic cerebrospinal venous insufficiency (CCSVI was described as a vascular condition characterized by anomalies of veins outside the skull was reported to be associated with multiple sclerosis (MS. The objective was to assess the associations between HLA DRB1*1501 status and the occurrence of CCSVI in MS patients. METHODOLOGY/PRINCIPAL FINDINGS: This study included 423 of 499 subjects enrolled in the Combined Transcranial and Extracranial Venous Doppler Evaluation (CTEVD study. The HLA DRB1*1501 status was obtained in 268 MS patients and 155 controls by genotyping rs3135005, a SNP associated with DRB1*1501 status. All subjects underwent a clinical examination and Doppler scan of the head and neck. The frequency of CCSVI was higher (OR = 4.52, p<0.001 in the MS group 56.0% vs. 21.9% in the controls group and also higher in the progressive MS group 69.8% vs. 49.5% in the non-progressive MS group. The 51.9% frequency of HLA DRB1*1501 positivity (HLA(+ in MS was higher compared (OR = 2.33, p<0.001 to 31.6% to controls. The HLA(+ frequency in the non-progressive (51.6% and progressive MS groups (52.3% was similar. The frequency of HLA(+ CCSVI(+ was 40.7% in progressive MS, 27.5% in non-progressive MS and 8.4% in controls. The presence of CCSVI was independent of HLA DRB1*1501 status in MS patients. CONCLUSIONS/SIGNIFICANCE: The lack of strong associations of CCSVI with HLA DRB1*1501 suggests that the role of the underlying associations of CCSVI in MS should be interpreted with caution. Further longitudinal studies should determine whether interactions between these factors can contribute to disease progression in MS.

Progress of Nuclear Hydrogen Program in Korea

International Nuclear Information System (INIS)

Lee, Won Jae

2009-01-01

To cope with dwindling fossil fuels and climate change, it is clear that a clean alternative energy that can replace fossil fuels is required. Hydrogen is considered a promising future energy solution because it is clean, abundant and storable and has a high energy density. As other advanced countries, the Korean government had established a long-term vision for transition to the hydrogen economy in 2005. One of the major challenges in establishing a hydrogen economy is how to produce massive quantities of hydrogen in a clean, safe and economical way. Among various hydrogen production methods, the massive, safe and economic production of hydrogen by water splitting using a very high temperature gas-cooled reactor (VHTR) can provide a success path to the hydrogen economy. Particularly in Korea, where usable land is limited, the nuclear production of hydrogen is deemed a practical solution due to its high energy density. To meet the expected demand for hydrogen, the Korea Atomic Energy Institute (KAERI) launched a nuclear hydrogen program in 2004 together with Korea Institute of Energy Research (KIER) and Korea Institute of Science and Technology (KIST). Then, the nuclear hydrogen key technologies development program was launched in 2006, which aims at the development and validation of key and challenging technologies required for the realization of the nuclear hydrogen production demonstration system. In 2008, Korean Atomic Energy Commission officially approved a long-term development plan of the nuclear hydrogen system technologies as in the figure below and now the nuclear hydrogen program became the national agenda. This presentation introduces the current status of nuclear hydrogen projects in Korea and the progress of the nuclear hydrogen key technologies development. Perspectives of nuclear process heat applications are also addressed

Changes in Clinical and Microbiological Periodontal Profiles Relate to Progression of Carotid Intima‐Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study

Science.gov (United States)

Desvarieux, Moïse; Demmer, Ryan T.; Jacobs, David R.; Papapanou, Panos N.; Sacco, Ralph L.; Rundek, Tatjana

2013-01-01

Background No prospective studies exist on the relationship between change in periodontal clinical and microbiological status and progression of carotid atherosclerosis. Methods and Results The Oral Infections and Vascular Disease Epidemiology Study examined 420 participants at baseline (68±8 years old) and follow‐up. Over a 3‐year median follow‐up time, clinical probing depth (PD) measurements were made at 75 766 periodontal sites, and 5008 subgingival samples were collected from dentate participants (average of 7 samples/subject per visit over 2 visits) and quantitatively assessed for 11 known periodontal bacterial species by DNA‐DNA checkerboard hybridization. Common carotid artery intima‐medial thickness (CCA‐IMT) was measured using high‐resolution ultrasound. In 2 separate analyses, change in periodontal status (follow‐up to baseline), defined as (1) longitudinal change in the extent of sites with a ≥3‐mm probing depth (Δ%PD≥3) and (2) longitudinal change in the relative predominance of bacteria causative of periodontal disease over other bacteria in the subgingival plaque (Δetiologic dominance), was regressed on longitudinal CCA‐IMT progression adjusting for age, sex, race/ethnicity, diabetes, smoking status, education, body mass index, systolic blood pressure, and low‐density lipoprotein cholesterol and high‐density lipoprotein cholesterol. Mean (SE) CCA‐IMT increased during follow‐up by 0.139±0.008 mm. Longitudinal IMT progression attenuated with improvement in clinical or microbial periodontal status. Mean CCA‐IMT progression varied inversely across quartiles of longitudinal improvement in clinical periodontal status (Δ%PD≥3) by 0.18 (0.02), 0.16 (0.01), 0.14 (0.01), and 0.07 (0.01) mm (P for trendperiodontal microbial status (Δetiologic dominance). Conclusion Longitudinal improvement in clinical and microbial periodontal status is related to a decreased rate of carotid artery IMT progression at 3‐year average

Moral status, justice, and the common morality: challenges for the principlist account of moral change.

Science.gov (United States)

Hodges, Kevin E; Sulmasy, Daniel P

2013-09-01

The theory of principlism elaborated by Beauchamp and Childress in Principles of Biomedical Ethics has become extremely influential in bioethics. The theory employs the idea of the common morality as a foundation for the principles of autonomy, beneficence, nonmaleficence, and justice. According to this account, the content of the common morality is universal and constant, while variability in morals is due to the fact that the issue of who is included within the scope of moral status evolves over time. This suggests that issues of moral status are not part of the common morality at all, and this presents a conundrum: questions of moral status seem central to any substantive account of justice, and any conception of the common morality that excludes moral status therefore seems inadequate for supporting a robust principle of justice. We argue that proponents of common morality theory are left with four options: (1) making moral status a part of the objective common morality and ignoring evidence that views about moral status do seem to vary over time and place; (2) excluding justice from the substantive content of the common morality; (3) taking common morality to be an imperfect approximation of an independently justified and universal foundationalist ethic against which the common morality is judged; or (4) weakening claims about the universality of common morality, thereby allowing the common morality to support a variety of principles of justice applicable only within particular communities that have specified the scope of moral status. We suspect that proponents of common morality theory will not view any of these options favorably, which raises questions about the ultimate contribution of that account.

The Community's research and development programme on decommissioning of nuclear installations (1989-1993). Annual progress report 1991

International Nuclear Information System (INIS)

1992-01-01

This is the second annual progress report of the European Community's programme (1989-93) of research on decommissioning of nuclear installations. It shows the status of the programme on 31 December 1991. This second progress report summarizes the objectives, scope and work programme of the 76 research contracts concluded, as well as the progress of work achieved and the results obtained in 1991

Fluctuations in Blood Marginal Zone B-Cell Frequencies May Reflect Migratory Patterns Associated with HIV-1 Disease Progression Status.

Science.gov (United States)

Gauvin, Julie; Chagnon-Choquet, Josiane; Poudrier, Johanne; Roger, Michel

2016-01-01

We have previously shown that overexpression of BLyS/BAFF was associated with increased relative frequencies of innate "precursor" marginal zone (MZ)-like B-cells in the blood of HIV-1-infected rapid and classic progressors. However, along with relatively normal BLyS/BAFF expression levels, these cells remain unaltered in elite-controllers (EC), rather, percentages of more mature MZ-like B-cells are decreased in the blood of these individuals. Fluctuations in frequencies of blood MZ-like B-cell populations may reflect migratory patterns associated with disease progression status, suggesting an important role for these cells in HIV-1 pathogenesis. We have therefore longitudinally measured plasma levels of B-tropic chemokines by ELISA-based technology as well as their ligands by flow-cytometry on blood B-cell populations of HIV-1-infected individuals with different rates of disease progression and uninfected controls. Migration potential of B-cell populations from these individuals were determined by chemotaxis assays. We found important modulations of CXCL13-CXCR5, CXCL12-CXCR4/CXCR7, CCL20-CCR6 and CCL25-CCR9 chemokine-axes and increased cell migration patterns in HIV progressors. Interestingly, frequencies of CCR6 expressing cells were significantly elevated within the precursor MZ-like population, consistent with increased migration in response to CCL20. Although we found little modulation of chemokine-axes in EC, cell migration was greater than that observed for uninfected controls, especially for MZ-like B-cells. Overall the immune response against HIV-1 may involve recruitment of MZ-like B-cells to peripheral sites. Moreover, our findings suggest that "regulated" attraction of these cells in a preserved BLyS/BAFF non-inflammatory environment, such as encountered in EC could be beneficial to the battle and even control of HIV.

Status of ITER

International Nuclear Information System (INIS)

Aymar, R.

2002-01-01

At the end of engineering design activities (EDA) in July 2001, all the essential elements became available to make a decision on construction of ITER. A sufficiently detailed and integrated engineering design now exists for a generic site, has been assessed for feasibility, and costed, and essential physics and technology R and D has been carried out to underpin the design choices. Formal negotiations have now begun between the current participants--Canada, Euratom, Japan, and the Russian Federation--on a Joint Implementation Agreement for ITER which also establishes the legal entity to run ITER. These negotiations are supported on technical aspects by Coordinated Technical Activities (CTA), which maintain the integrity of the project, for the good of all participants, and concentrate on preparing for procurement by industry of the longest lead items, and for formal application for a construction license with the host country. This paper highlights the main features of the ITER design. With cryogenically-cooled magnets close to neutron-generating plasma, the design of shielding with adequate access via port plugs for auxiliaries such as heating and diagnostics, and of remote replacement and refurbishing systems for in-vessel components, are particularly interesting nuclear technology challenges. Making a safety case for ITER to satisfy potential regulators and to demonstrate, as far as possible at this stage, the environmental attractiveness of fusion as an energy source, is also important. The paper gives illustrative details on this work, and an update on the progress of technical preparations for construction, as well as the status of the above negotiations

Phytoextraction of Cd-Contaminated Soils: Current Status and Future Challenges

OpenAIRE

Li, Jin-Tian; Baker, Alan J. M.; Ye, Zhi-Hong; Wang, Hong-Bin; Shu, Wen-Sheng

2012-01-01

Cadmium (Cd) is one of the most toxic and widely distributed pollutants in the environment. Cadmium contamination of soils has posed a serious threat to safe food production in many parts of the world. The authors present a comprehensive review of present status of phytoextraction technology for cleaning up Cd-contaminated soils, based primarily on the data resulting from both laboratory and field-scale studies that have been conducted to assess or improve the Cd phytoextraction potential of ...

Worldwide status of HTR development

International Nuclear Information System (INIS)

1978-06-01

The International Atomic Energy Agency convened a technical committee meeting on high temperature reactors (HTRs) from 12-14 Dec. 1977 at Agency Headquarters to provide a forum for the exchange of information on the status of HTR development programmes and to receive advice on the Agency programme in this field. The continuing high level of international interest in HTRs was evidenced by the participation from 11 countries and 2 organizations: Austria, Belgium, France, Federal Republic of Germany, Japan, Netherlands, Poland, Switzerland, Union of Soviet Socialist Republics, United Kingdom of Great Britain, United States of America, Commission of the European Communities, and the OECD Nuclear Energy Agency. In order to promote the continuing exchange of technical information through the offices of the IAEA, a recommendation was made that the Agency establish a standing International Working Group on High Temperature Reactors (IWGHTR). This recommendation is being implemented in 1978. Considerable information on recent progress in HTR development was present at the technical committee meeting in technical reports and in progress reports on HTR development programmes. Since this material will not be published, this summary report on the worldwide status of HTR development at the beginning of 1978 has been prepared, based primarily on information presented at the December 1977 meeting

Present status of accelerator-based BNCT: Focus on developments in Argentina

International Nuclear Information System (INIS)

Cartelli, D.; Capoulat, M.E.; Bergueiro, J.; Gagetti, L.; Suárez Anzorena, M.; Grosso, M.F. del; Baldo, M.; Castell, W.; Padulo, J.; Suárez Sandín, J.C.; Igarzabal, M.; Erhardt, J.; Mercuri, D.

2015-01-01

In this work we provide some information on the present status of accelerator-based BNCT (AB-BNCT) worldwide and subsequently concentrate on the recent accelerator technology developments in Argentina. - Highlights: • The current status of projects and associated facilities for AB-BNCT worldwide is shown. • Only low (few MeV) energy accelerators are included. • The recent progress of the Argentine AB-BNCT program is described.

Research Progress on Fe-based Amorphous Coatings

Directory of Open Access Journals (Sweden)

LIANG Xiu-bing

2017-09-01

Full Text Available The latest research progresses on Fe-based amorphous coatings were reviewed. The typical alloy system and the classification of Fe-based amorphous coatings were clarified. The status, progress and development of the Fe-based amorphous coatings prepared by thermal spray processing and laser cladding process were discussed. The main mechanical properties and potential applications of the Fe-based amorphous coatings were also described. Furthermore, based on the main problems mentioned above, the future development of the Fe-based amorphous coatings was discussed, including the exploitation preparation technologies of high amorphous content of the Fe-based coatings, the development of the low cost and high performance Fe-based coating alloys system, the broadening application of Fe-based amorphous coatings, and so on.

Sustainable Development: The Challenge for Community Development.

Science.gov (United States)

Gamble, Dorothy N.; Weil, Marie O.

1997-01-01

Five areas of inquiry shape the sustainable development movement: environmental movement, women's movement, overpopulation concerns, critique of development models, and new indicators of social progress. Community development workers are challenged to prepare local development projects within a sustainable development framework. (SK)

Molluscs and echinoderms aquaculture: biological aspects, current status, technical progress and future perspectives for the most promising species in Italy

Directory of Open Access Journals (Sweden)

Antonio Pais

2012-10-01

Full Text Available Shellfish aquaculture is a widespread activity in the Italian peninsula. However, only two bivalve species are mainly cultured along the coastline of that country: the Mediterranean mussel Mytilus galloprovincialis and the Manila clam Venerupis philippinarum (Ruditapes philippinarum. By contrast, just a few other mollusc species of commercial interest are scarcely reared at a small-scale level. After analysing the current status of Italian shellfish production, this paper reports and discusses the potential for culturing several different invertebrate species [i.e., the European flat oyster Ostrea edulis, the grooved carpet shell Venerupis decussata (Ruditapes decussatus, the razor clams Ensis minor and Solen marginatus, the cephalopod Octopus vulgaris, and the purple sea urchin Paracentrotus lividus] in this country. In addition, a detailed overview of the progress made in aquacultural techniques for these species in the Mediterranean basin is presented, highlighting the most relevant bottlenecks and the way forward to shift from the experimental to the aquaculture phase. Finally, an outlook of the main economic and environmental benefits arising from these shellfish culture practices is also given.

A Portfolio Analysis Tool for Measuring NASAs Aeronautics Research Progress toward Planned Strategic Outcomes

Science.gov (United States)

Tahmasebi, Farhad; Pearce, Robert

2016-01-01

Description of a tool for portfolio analysis of NASA's Aeronautics research progress toward planned community strategic Outcomes is presented. The strategic planning process for determining the community Outcomes is also briefly described. Stakeholder buy-in, partnership performance, progress of supporting Technical Challenges, and enablement forecast are used as the criteria for evaluating progress toward Outcomes. A few illustrative examples are also presented.

Understanding the epoch of cosmic reionization challenges and progress

CERN Document Server

2016-01-01

The aim of this volume is to summarize the current status and future outlook of the reionization field on both the theoretical and observational fronts. It brings together leading experts in many sub-disciplines, highlighting the measurements that are likely to drive the growing understanding of reionization and the cosmic dawn, and lays out a roadmap to interpreting the wealth of upcoming observations. The birth of the first stars and galaxies, and their impact on the diffuse matter perme­ating the early Universe, is one of the final frontiers in cosmology. Recently, measure­ments of the fluctuations in the cosmic microwave background (CMB), sourced only a few hundred thousand years after the Big Bang, provided robust insight into the overall physical content of our Universe. On the other end of the timeline, groundbreaking telescopes provide us a picture of the complexities of the galaxy-rich universe in which we now live. However, we know almost nothing about the astrophysics of the first billion years. ...

Disability in progressive MS is associated with T2 lesion changes

DEFF Research Database (Denmark)

Ammitzbøll, Cecilie; Dyrby, Tim Bjørn; Lyksborg, Mark

2017-01-01

Background: Progressive multiple sclerosis (MS) is characterized by diffuse changes on brain magnetic resonance imaging (MRI), which complicates the use of MRI as a diagnostic and prognostic marker. The relationship between MRI measures (conventional and non-conventional) and clinical disability...... in progressive MS therefore warrants further investigation. Objective: To investigate the relationship between clinical disability and MRI measures in patients with progressive MS. Methods: Data from 93 primary and secondary progressive MS patients who had participated in 3 phase 2 clinical trials were included...... matter. Disability was assessed by the Expanded Disability Status Scale (EDSS) and the MS functional composite. Results: T2 lesion volume was associated with impairment by all clinical measures. MD and MTR in T2 lesions were significantly related to disability, and lower FA values correlated with worse...

The WIMP Paradigm: Current Status

International Nuclear Information System (INIS)

Feng, Jonathan

2011-01-01

The WIMP paradigm is the glue that joins together much of the high energy and cosmic frontiers. It postulates that most of the matter in the Universe is made of weakly-interacting massive particles, with implications for a broad range of experiments and observations. I will review the WIMP paradigm's underlying motivations, its current status in view of rapid experimental progress on several fronts, and recent theoretical variations on the WIMP paradigm theme.

Teaching Racism: Using Experiential Learning to Challenge the Status Quo

Science.gov (United States)

Loya, Melody Aye; Cuevas, Mo

2010-01-01

Teaching about racism creates challenging issues for educators and students alike. Using experiential learning and a public-access curriculum to teach about racism and social inequality, graduate and undergraduate students participated in this elective course. The hybrid "minimester" course focused on affective responses to classroom activities,…

The Community's research and development programme on decommissioning of nuclear installations. Second annual progress report (year 1986)

International Nuclear Information System (INIS)

1987-01-01

This is the second annual progress report of the European Community's programme (1984-88) of research on the decommissioning of nuclear installations. It shows the status of the programme on 31 December 1986. This second progress report describes the objectives, scope and work programme of the 58 research contracts concluded, as well as the progress of work achieved and the results obtained in 1986

Advances and Challenges in Convergent Communication Networks

DEFF Research Database (Denmark)

Toral-Cruz, Homero; Mihovska, Albena

2017-01-01

Welcome to this special issue of Wireless Personal Communications on Advances and Challenges in Convergent Communication Networks. The main purpose of this special issue is to present new progresses and challenges in convergent networks. Communication networks play an important role in our daily...... life because they allow communicating and sharing contents between heterogeneous nodes around the globe. The emergence of multiple network architectures and emerging technologies have resulted in new applications and services over a heterogeneous network. This heterogeneous network has undergone...... significant challenges in recent years, such as the evolution to a converged network with the capability to support multiple services, while maintaining a satisfactory level of QoE/QoS, security, efficiency and trust. The special issue on Advances and Challenges in Convergent Communication Networks...

Diffusion tensor MRI shows progressive changes in the hippocampus and dentate gyrus after status epilepticus in rat - histological validation with Fourier-based analysis.

Science.gov (United States)

Salo, Raimo A; Miettinen, Tuukka; Laitinen, Teemu; Gröhn, Olli; Sierra, Alejandra

2017-05-15

Imaging markers for monitoring disease progression, recovery, and treatment efficacy are a major unmet need for many neurological diseases, including epilepsy. Recent evidence suggests that diffusion tensor imaging (DTI) provides high microstructural contrast even outside major white matter tracts. We hypothesized that in vivo DTI could detect progressive microstructural changes in the dentate gyrus and the hippocampal CA3bc in the rat brain after status epilepticus (SE). To test this hypothesis, we induced SE with systemic kainic acid or pilocarpine in adult male Wistar rats and subsequently scanned them using in vivo DTI at five time-points: prior to SE, and 10, 20, 34, and 79 days post SE. In order to tie the DTI findings to changes in the tissue microstructure, myelin- and glial fibrillary acidic protein (GFAP)-stained sections from the same animals underwent Fourier analysis. We compared the Fourier analysis parameters, anisotropy index and angle of myelinated axons or astrocyte processes, to corresponding DTI parameters, fractional anisotropy (FA) and the orientation angle of the principal eigenvector. We found progressive detectable changes in DTI parameters in both the dentate gyrus (FA, axial diffusivity [D || ], linear anisotropy [CL] and spherical anisotropy [CS], pFourier analysis revealed that both myelinated axons and astrocyte processes played a role in the water diffusion anisotropy changes detected by DTI in individual portions of the dentate gyrus (suprapyramidal blade, mid-portion, and infrapyramidal blade). In the whole dentate gyrus, myelinated axons markedly contributed to the water diffusion changes. In CA3bc as well as in CA3b and CA3c, both myelinated axons and astrocyte processes contributed to water diffusion anisotropy and orientation. Our study revealed that DTI is a promising method for noninvasive detection of microstructural alterations in the hippocampus proper. These alterations may be potential imaging markers for epileptogenesis

Overview of the present status and challenges of neutrino oscillation physics

Energy Technology Data Exchange (ETDEWEB)

Mocioiu, Irina [Pennsylvania State University, 104 Davey Lab, University Park, PA 16802 (United States)

2012-11-20

This is an overview of the current status of neutrino oscillation physics, including atmospheric, solar, reactor and accelerator neutrino experiments. After summarizing our present understanding of all data, I discuss the open questions and how they might be addressed in the future. I also discuss how neutrinos can be used to learn about new physics and astrophysics.

Systematic evaluation program. Status summary report

International Nuclear Information System (INIS)

1982-01-01

Purpose of the SEP is to review the designs of ten older operating nuclear power plants to document their safety. The SEP topics, design basis event, and progress are discussed in the first section of this document. The topic numbers, reviewing branch, status, remarks, and dates are tabulated in the second section. In the third section, the topic number, title, SAR schedule, and SER schedule are tabulated

Smart Grid Status and Metrics Report

Energy Technology Data Exchange (ETDEWEB)

Balducci, Patrick J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Weimar, Mark R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kirkham, Harold [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2014-07-01

To convey progress made in achieving the vision of a smart grid, this report uses a set of six characteristics derived from the National Energy Technology Laboratory Modern Grid Strategy. It measures 21 metrics to provide insight into the grid’s capacity to embody these characteristics. This report looks across a spectrum of smart grid concerns to measure the status of smart grid deployment and impacts.

LSST telescope and site status

Science.gov (United States)

Gressler, William J.

2016-07-01

The Large Synoptic Survey Telescope (LSST) Project1 received its construction authorization from the National Science Foundation in August 2014. The Telescope and Site (T and S) group has made considerable progress towards completion in subsystems required to support the scope of the LSST science mission. The LSST goal is to conduct a wide, fast, deep survey via a 3-mirror wide field of view optical design, a 3.2-Gpixel camera, and an automated data processing system. The summit facility is currently under construction on Cerro Pachón in Chile, with major vendor subsystem deliveries and integration planned over the next several years. This paper summarizes the status of the activities of the T and S group, tasked with design, analysis, and construction of the summit and base facilities and infrastructure necessary to control the survey, capture the light, and calibrate the data. All major telescope work package procurements have been awarded to vendors and are in varying stages of design and fabrication maturity and completion. The unique M1M3 primary/tertiary mirror polishing effort is completed and the mirror now resides in storage waiting future testing. Significant progress has been achieved on all the major telescope subsystems including the summit facility, telescope mount assembly, dome, hexapod and rotator systems, coating plant, base facility, and the calibration telescope. In parallel, in-house efforts including the software needed to control the observatory such as the scheduler and the active optics control, have also seen substantial advancement. The progress and status of these subsystems and future LSST plans during this construction phase are presented.

Disclosure of HIV status between parents and children in Uganda in ...

African Journals Online (AJOL)

While disclosure of HIV sero-status is encouraged in the management of the HIV and AIDS epidemic, it remains a challenge, especially among family members. This article examines the moral dilemmas and pragmatic incentives surrounding disclosure of HIV status in contemporary Uganda. Our findings are based on 12 ...

Binary combination of epsilon-poly-L-lysine and isoeugenol affect progression of spoilage microbiota in fresh turkey meat, and delay onset of spoilage in Pseudomonas putida challenged meat.

Science.gov (United States)

Hyldgaard, Morten; Meyer, Rikke L; Peng, Min; Hibberd, Ashley A; Fischer, Jana; Sigmundsson, Arnar; Mygind, Tina

2015-12-23

Proliferation of microbial population on fresh poultry meat over time elicits spoilage when reaching unacceptable levels, during which process slime production, microorganism colony formation, negative organoleptic impact and meat structure change are observed. Spoilage organisms in raw meat, especially Gram-negative bacteria can be difficult to combat due to their cell wall composition. In this study, the natural antimicrobial agents ε-poly-L-lysine (ε-PL) and isoeugenol were tested individually and in combinations for their activities against a selection of Gram-negative strains in vitro. All combinations resulted in additive interactions between ε-PL and isoeugenol towards the bacteria tested. The killing efficiency of different ratios of the two antimicrobial agents was further evaluated in vitro against Pseudomonas putida. Subsequently, the most efficient ratio was applied to a raw turkey meat model system which was incubated for 96 h at spoilage temperature. Half of the samples were challenged with P. putida, and the bacterial load and microbial community composition was followed over time. CFU counts revealed that the antimicrobial blend was able to lower the amount of viable Pseudomonas spp. by one log compared to untreated samples of challenged turkey meat, while the single compounds had no effect on the population. However, the compounds had no effect on Pseudomonas spp. CFU in unchallenged meat. Next-generation sequencing offered culture-independent insight into population diversity and changes in microbial composition of the meat during spoilage and in response to antimicrobial treatment. Spoilage of unchallenged turkey meat resulted in decreasing species diversity over time, regardless of whether the samples received antimicrobial treatment. The microbiota composition of untreated unchallenged meat progressed from a Pseudomonas spp. to a Pseudomonas spp., Photobacterium spp., and Brochothrix thermosphacta dominated food matrix on the expense of low

Progressive multifocal leukoencephalopathy limited to the brain stem

Energy Technology Data Exchange (ETDEWEB)

Kastrup, O.; Maschke, M.; Diener, H.C. [Neurologische Universitaetsklinik, University of Essen (Germany); Wanke, I. [Department of Neuroradiology, University of Essen (Germany)

2002-03-01

Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating slow-virus encephalitis caused by the JC polyomavirus in 2-5% of patients with AIDS. MRI typically shows multiple lesions in the cerebral hemispheres. We present a rare case of rapidly evolving and lethal PML with a severe bulbar syndrome and spastic tetraparesis in a patient with AIDS. MRI showed high-signal lesions on T2-weighted images confined to the brain stem, extending from the medulla oblongata to the midbrain. JC virus polymerase chain reaction in cerebrospinal fluid was positive, and neuropathology showed the findings of PML. This case was also notable because of the rapid progression despite improved immune status with antiretroviral therapy. (orig.)

Progress and Challenges of Protecting North American Ash Trees from the Emerald Ash Borer Using Biological Control

Directory of Open Access Journals (Sweden)

Jian J. Duan

2018-03-01

Full Text Available After emerald ash borer (EAB, Agrilus planipennis Fairmaire, was discovered in the United States, a classical biological control program was initiated against this destructive pest of ash trees (Fraxinus spp.. This biocontrol program began in 2007 after federal regulatory agencies and the state of Michigan approved release of three EAB parasitoid species from China: Tetrastichus planipennisi Yang (Eulophidae, Spathius agrili Yang (Braconidae, and Oobius agrili Zhang and Huang (Encyrtidae. A fourth EAB parasitoid, Spathius galinae Belokobylskij (Braconidae from Russia, was approved for release in 2015. We review the rationale and ecological premises of the EAB biocontrol program, and then report on progress in North American ash recovery in southern Michigan, where the parasitoids were first released. We also identify challenges to conserving native Fraxinus using biocontrol in the aftermath of the EAB invasion, and provide suggestions for program improvements as EAB spreads throughout North America. We conclude that more work is needed to: (1 evaluate the establishment and impact of biocontrol agents in different climate zones; (2 determine the combined effect of EAB biocontrol and host plant resistance or tolerance on the regeneration of North American ash species; and (3 expand foreign exploration for EAB natural enemies throughout Asia.

CAR-T therapy for leukemia: progress and challenges.

Science.gov (United States)

Wang, Xin; Xiao, Qing; Wang, Zhe; Feng, Wen-Li

2017-04-01

Despite the rapid development of therapeutic strategies, leukemia remains a type of difficult-to-treat hematopoietic malignancy that necessitates introduction of more effective treatment options to improve life expectancy and quality of patients. Genetic engineering in adoptively transferred T cells to express antigen-specific chimeric antigen receptors (CARs) has proved highly powerful and efficacious in inducing sustained responses in patients with refractory malignancies, as exemplified by the success of CD19-targeting CAR-T treatment in patients with relapsed acute lymphoblastic leukemia. Recent strategies, including manipulating intracellular activating domains and transducing viral vectors, have resulted in better designed and optimized CAR-T cells. This is further facilitated by the rapid identification of an accumulating number of potential leukemic antigens that may serve as therapeutic targets for CAR-T cells. This review will provide a comprehensive background and scrutinize recent important breakthrough studies on anti-leukemia CAR-T cells, with focus on recently identified antigens for CAR-T therapy design and approaches to overcome critical challenges. Copyright © 2016 Elsevier Inc. All rights reserved.

A survey on the progress with implementation of the radiography profession's career progression framework in UK radiotherapy centres

International Nuclear Information System (INIS)

James, Sarah; Beardmore, Charlotte; Dumbleton, Claire

2012-01-01

Aim: The purpose of the survey was to benchmark the progress with implementing the radiography profession's career progression framework within radiotherapy centres across the United Kingdom (UK). Methods: A survey questionnaire was constructed using the Survey Monkey™ tool to assess implementation of the career progression framework of the Society and College of Radiographers. Once constructed, an on line link to the survey questionnaire was emailed to all radiotherapy centre managers in the UK (N = 67) who were invited to provide one response per centre. The survey comprised twenty nine questions which were grouped into nine sections. Key results: The workforce profile indicates that increases in assistant, advanced and consultant level practitioners are required to meet National Radiotherapy Advisory Group recommendations with only a small number of centres having fully implemented the career progression framework. The overall vacancy level across the therapeutic radiography workforce was 4.6% at the time of the survey. Conclusions: and Recommendations: The survey has highlighted some progress with implementation of the career progression framework across the UK since its launch in 2000. However the current level of implementation demonstrated is disappointing considering it is a key recommendation within the NRAG Report 2007 with respect to England. It is recommended that all centres undertake a multi-professional workforce review to embed the career progression framework within their service in order to meet the workforce challenge associated with the required anticipated large growth in radiotherapy capacity.

The OPTHER Project: Progress toward the THz Amplifier

DEFF Research Database (Denmark)

Paoloni, C; Brunetti, F; Di Carlo, A

2011-01-01

This paper describes the status of the OPTHER (OPtically driven TeraHertz AmplifiERs) project and progress toward the THz amplifier realization. This project represents a considerable advancement in the field of high frequency amplification. The design and realization of a THz amplifier within...... this project is a consolidation of efforts at the international level from the leading scientific and industrial European organizations working with vacuum electronics....

Overview of Botanical Status in EU, USA, and Thailand

Directory of Open Access Journals (Sweden)

Weena Jiratchariyakul

2013-01-01

Full Text Available The botanical status in EU, USA, and Thailand is different owing to the regulatory status, the progress of science, and the influence of culture and society. In the EU, botanicals are positioned as herbal medicinal products and food supplements, in the US they are regulated as dietary supplements but often used as traditional medicines, and in Thailand, they are regulated and used as traditional medicines. Information for some of the most popular botanicals from each country is included in this review.

2018 Status Report of NP04 (ProtoDUNE-SP)

CERN Document Server

Touramanis, C

2018-01-01

The NP04 Liquid Argon TPC has been constructed in the CERN Neutrino Facility and is in final preparation for taking beam data before the end of the current beam period at CERN. Progress in the last twelve months, current status, and plans are presented.

Urban growth and water access in sub-Saharan Africa: Progress, challenges, and emerging research directions.

Science.gov (United States)

Dos Santos, S; Adams, E A; Neville, G; Wada, Y; de Sherbinin, A; Mullin Bernhardt, E; Adamo, S B

2017-12-31

For the next decade, the global water crisis remains the risk of highest concern, and ranks ahead of climate change, extreme weather events, food crises and social instability. Across the globe, nearly one in ten people is without access to an improved drinking water source. Least Developed Countries (LDCs) especially in sub-Saharan Africa (SSA) are the most affected, having disproportionately more of the global population without access to clean water than other major regions. Population growth, changing lifestyles, increasing pollution and accelerating urbanization will continue to widen the gap between the demand for water and available supply especially in urban areas, and disproportionately affect informal settlements, where the majority of SSA's urban population resides. Distribution and allocation of water will be affected by climate-induced water stresses, poor institutions, ineffective governance, and weak political will to address scarcity and mediate uncertainties in future supply. While attempts have been made by many scientists to examine different dimensions of water scarcity and urban population dynamics, there are few comprehensive reviews, especially focused on the particular situation in Sub-Saharan Africa. This paper contributes to interdisciplinary understanding of urban water supply by distilling and integrating relevant empirical knowledge on urban dynamics and water issues in SSA, focusing on progress made and associated challenges. It then points out future research directions including the need to understand how alternatives to centralized water policies may help deliver sustainable water supply to cities and informal settlements in the region. Copyright © 2017 Elsevier B.V. All rights reserved.

Status of the intense pulsed neutron source

International Nuclear Information System (INIS)

Brown, B.S.; Carpenter, J.M.; Crawford, R.K.; Rauchas, A.V.; Schulke, A.W.; Worlton, T.G.

1988-01-01

IPNS is not unique in having concerns about the level of funding, and the future looks good despite these concerns. This report details the progress made at IPNS during the last two years. Other papers in these proceedings discuss in detail the status of the enriched uranium Booster target, the two instruments that are under construction, GLAD and POSY II, and a proposal for research on an Advanced Pulsed Neutron Source (ASPUN) that has been submitted to the Department of Energy (DOE). Further details on IPNS are available in the IPNS Progress Report 1987--1988, available by writing the IPNS Division Office. 9 refs., 3 tabs

Long-Term Results of Conformal Radiotherapy for Progressive Airway Amyloidosis

Energy Technology Data Exchange (ETDEWEB)

Truong, Minh Tam, E-mail: mitruong@bu.edu [Department of Radiation Oncology, Amyloid Treatment and Research Program, Boston University School of Medicine, Boston Medical Center, Boston, MA (United States); Kachnic, Lisa A. [Department of Radiation Oncology, Amyloid Treatment and Research Program, Boston University School of Medicine, Boston Medical Center, Boston, MA (United States); Grillone, Gregory A. [Department of Otolaryngology, Amyloid Treatment and Research Program, Boston University School of Medicine, Boston Medical Center, Boston, MA (United States); Bohrs, Harry K.; Lee, Richard [Department of Radiation Oncology, Amyloid Treatment and Research Program, Boston University School of Medicine, Boston Medical Center, Boston, MA (United States); Sakai, Osamu [Department of Radiology, Amyloid Treatment and Research Program, Boston University School of Medicine, Boston Medical Center, Boston, MA (United States); Berk, John L. [Department of Medicine, Amyloid Treatment and Research Program, Boston University School of Medicine, Boston Medical Center, Boston, MA (United States)

2012-06-01

Purpose: To evaluate the efficacy of conformal external beam radiotherapy (RT) for local control of progressive airway amyloidosis. Methods and Materials: We conducted a retrospective review of patients with biopsy-proven progressive airway amyloidosis treated with conformal RT between 2000 and 2006 at Boston Medical Center. The patients were evaluated for performance status and pulmonary function, with computed tomography and endoscopy after RT compared with the pretreatment studies. Local control was defined as the lack of progression of airway wall thickening on computed tomography imaging and stable endobronchial deposits by endoscopy. Results: A total of 10 symptomatic airway amyloidosis patients (3 laryngeal and 7 tracheobronchial) received RT to a median total dose of 20 Gy in 10 fractions within 2 weeks. At a median follow-up of 6.7 years (range, 1.5-10.3), 8 of the 10 patients had local control. The remaining 2 patients underwent repeat RT 6 and 8.4 months after initial RT, 1 for persistent bronchial obstruction and 1 for progression of subglottic amyloid disease with subsequent disease control. The Eastern Cooperative Oncology Group performance status improved at a median of 18 months after RT compared with the baseline values, from a median score of 2 to a median of 1 (p = .035). Airflow (forced expiratory volume in 1 second) measurements increased compared with the baseline values at each follow-up evaluation, reaching a 10.7% increase (p = .087) at the last testing (median duration, 64.8 months). Acute toxicity was limited to Grade 1-2 esophagitis, occurring in 40% of patients. No late toxicity was observed. Conclusions: RT prevented progressive amyloid deposition in 8 of 10 patients, resulting in a marginally increased forced expiratory volume in 1 second, and improved functional capacity, without late morbidity.

Adaptive changes in renal mitochondrial redox status in diabetic nephropathy

Energy Technology Data Exchange (ETDEWEB)

Putt, David A.; Zhong, Qing; Lash, Lawrence H., E-mail: l.h.lash@wayne.edu

2012-01-15

Nephropathy is a serious and common complication of diabetes. In the streptozotocin (STZ)-treated rat model of diabetes, nephropathy does not typically develop until 30 to 45 days post-injection, although hyperglycemia occurs within 24 h. We tested the hypothesis that chronic hyperglycemia results in a modest degree of oxidative stress that is accompanied by compensatory changes in certain antioxidants and mitochondrial redox status. We propose that as kidneys progress to a state of diabetic nephropathy, further adaptations occur in mitochondrial redox status. Basic parameters of renal function in vivo and several parameters of mitochondrial function and glutathione (GSH) and redox status in isolated renal cortical mitochondria from STZ-treated and age-matched control rats were examined at 30 days and 90 days post-injection. While there was no effect of diabetes on blood urea nitrogen, measurement of other, more sensitive parameters, such as urinary albumin and protein, and histopathology showed significant and progressive worsening in diabetic rats. Thus, renal function is compromised even prior to the onset of frank nephropathy. Changes in mitochondrial respiration and enzyme activities indicated existence of a hypermetabolic state. Higher mitochondrial GSH content and rates of GSH transport into mitochondria in kidneys from diabetic rats were only partially due to changes in expression of mitochondrial GSH carriers and were mostly due to higher substrate supply. Although there are few clear indicators of oxidative stress, there are several redox changes that occur early and change further as nephropathy progresses, highlighting the complexity of the disease. Highlights: ►Adaptive changes in renal mitochondrial and redox status in diabetic rats. ►Modest renal dysfunction even prior to onset of nephropathy. ►Elevated concentrations of mitochondrial GSH in diabetic kidneys. ►Change in GSH due partly to increased protein expression of transporter. �

Adaptive changes in renal mitochondrial redox status in diabetic nephropathy

International Nuclear Information System (INIS)

Putt, David A.; Zhong, Qing; Lash, Lawrence H.

2012-01-01

Nephropathy is a serious and common complication of diabetes. In the streptozotocin (STZ)-treated rat model of diabetes, nephropathy does not typically develop until 30 to 45 days post-injection, although hyperglycemia occurs within 24 h. We tested the hypothesis that chronic hyperglycemia results in a modest degree of oxidative stress that is accompanied by compensatory changes in certain antioxidants and mitochondrial redox status. We propose that as kidneys progress to a state of diabetic nephropathy, further adaptations occur in mitochondrial redox status. Basic parameters of renal function in vivo and several parameters of mitochondrial function and glutathione (GSH) and redox status in isolated renal cortical mitochondria from STZ-treated and age-matched control rats were examined at 30 days and 90 days post-injection. While there was no effect of diabetes on blood urea nitrogen, measurement of other, more sensitive parameters, such as urinary albumin and protein, and histopathology showed significant and progressive worsening in diabetic rats. Thus, renal function is compromised even prior to the onset of frank nephropathy. Changes in mitochondrial respiration and enzyme activities indicated existence of a hypermetabolic state. Higher mitochondrial GSH content and rates of GSH transport into mitochondria in kidneys from diabetic rats were only partially due to changes in expression of mitochondrial GSH carriers and were mostly due to higher substrate supply. Although there are few clear indicators of oxidative stress, there are several redox changes that occur early and change further as nephropathy progresses, highlighting the complexity of the disease. Highlights: ►Adaptive changes in renal mitochondrial and redox status in diabetic rats. ►Modest renal dysfunction even prior to onset of nephropathy. ►Elevated concentrations of mitochondrial GSH in diabetic kidneys. ►Change in GSH due partly to increased protein expression of transporter. �

TRAGEDI CHALLENGER (TINJAUAN ETIKA KANTIAN DAN ETIKA UTILITARIAN)

OpenAIRE

Sudaryanto, Sudaryanto

2016-01-01

A lot of scientific experiments motivated by utilitarian attitudes. Experiments are expected to give satisfactory results or benefits. If an experiment has been carried out with the correct procedure, then the failure of an experiment is morally acceptable, because the nature of the experiments it is always a risk. The launch of the Challenger can be incorporated into the experimental category. Through the review process, engineering procedures and the launch of Challenger's failure status ca...

Tragedi Challenger (Tinjauan Etika Kantian Dan Etika Utilitarian)

OpenAIRE

Sudaryanto, Sudaryanto

2015-01-01

A lot of scientific experiments motivated by utilitarian attitudes. Experiments are expected to give satisfactory results or benefits. If an experiment has been carried out with the correct procedure, then the failure of an experiment is morally acceptable, because the nature of the experiments it is always a risk. The launch of the Challenger can be incorporated into the experimental category. Through the review process, engineering procedures and the launch of Challenger's failure status ca...

Progression og underviserkompetencer

Directory of Open Access Journals (Sweden)

Lene Tortzen Bager

2014-03-01

entrepreneurship. The study uses categories such as didactics, working processes in academic courses or courses at university as key themes. Participating teachers’ descriptions of their concepts of entrepreneurship in their teaching practices are used to chart their progress. This material provides an insight into the teachers’ reflections on their development processes, challenges and different modes of teacher authority related to entrepreneurship teaching in universities. Together, the gathered data contribute to discussions on student teacher development by identifying the importance of the teachers’ motivation as a precondition for professional and educational development.

Atezolizumab in platinum-treated locally advanced or metastatic urothelial carcinoma: post-progression outcomes from the phase II IMvigor210 study.

Science.gov (United States)

Necchi, A; Joseph, R W; Loriot, Y; Hoffman-Censits, J; Perez-Gracia, J L; Petrylak, D P; Derleth, C L; Tayama, D; Zhu, Q; Ding, B; Kaiser, C; Rosenberg, J E

2017-12-01

Conventional criteria for tumor progression may not fully reflect the clinical benefit of immunotherapy or appropriately guide treatment decisions. The phase II IMvigor210 study demonstrated the efficacy and safety of atezolizumab, a programmed death-ligand 1-directed antibody, in patients with platinum-treated locally advanced or metastatic urothelial carcinoma. Patients could continue atezolizumab beyond Response Evaluation Criteria In Solid Tumors (RECIST) v1.1 progression at the investigator's discretion: this analysis assessed post-progression outcomes in these patients. Patients were treated with atezolizumab 1200 mg i.v. every 3 weeks until loss of clinical benefit. Efficacy and safety outcomes in patients who experienced RECIST v1.1 progression and did, or did not, continue atezolizumab were analyzed descriptively. In total, 220 patients who experienced progression from the overall cohort (n = 310) were analyzed: 137 continued atezolizumab for ≥ 1 dose after progression, 19 received other systemic therapy, and 64 received no further systemic therapy. Compared with those who discontinued, patients continuing atezolizumab beyond progression were more likely to have had a baseline Eastern Cooperative Oncology Group performance status of 0 (43.1% versus 31.3%), less likely to have had baseline liver metastases (27.0% versus 41.0%), and more likely to have had an initial response to atezolizumab (responses in 11.7% versus 1.2%). Five patients (3.6%) continuing atezolizumab after progression had subsequent responses compared with baseline measurements. Median post-progression overall survival was 8.6 months in patients continuing atezolizumab, 6.8 months in those receiving another treatment, and 1.2 months in those receiving no further treatment. Atezolizumab exposure-adjusted adverse event frequencies were generally similar before and following progression. In this single-arm study, patients who continued atezolizumab beyond RECIST v1

Status of the ITER construction preparation

International Nuclear Information System (INIS)

Holtkamp, N.; Janeschitz, G.

2007-01-01

ITER as an organization has been established officially on Nov 21st 2006. Together with the creation of this international body the participating countries and the ITER International Organization have committed to a construction schedule of about 10 years under a fixed budget. ITER for the first time should bring together reactor-grade plasma and current technology, in an attempt to see how a viable energy source can be built. Apart from the scientific challenge, ITER will be the first mega-science project that is to be build under an ''in-kind'' arrangement in which contributions from the collaborating countries are given in terms of ready-to-install subsystems for the facility and only to a small extent in cash. The main engineering challenge is to turn the existing designs into procurement packages that can be executed within the countries on time, while ensuring an integrated design. In addition maintaining some flexibility in the layout to respond to changes in understanding as the device operates is key to every scientific endeavour. The current ITER design was completed in 2001, and a number of changes have been proposed since then. A design review process is underway to address outstanding design issues, to identify any new ones, to integrate solutions, and to ensure that the schedule and objectives can be met. This involves the expertise of the ITER Project Team, along with experts from the participating countries, and will focus initially on long lead items and related basic systems to provide a framework for later procurements. In addition to the above, the paper will address the status of the adaptation to the Cadarache site near Aix-en-Provence, the licensing process of the nuclear facility within France, and will show the construction progress. (orig.)

Progress and status of the Integral Fast Reactor (IFR) development program

International Nuclear Information System (INIS)

Chang, Yoon I.

1992-01-01

In the Integral Fast Reactor (IFR) development program, the entire reactor system -- reactor, fuel cycle, and waste process is being developed and optimized at the same time as a single integral entity. The ALMR reactor plant design is being developed by an industrial team headed by General Electric and is presented in a companion paper. Detailed discussions on the present status of the IFR technology development activities in the areas of fuels, pyroprocessing, safety, core design, and fuel cycle demonstration are presented in the other two companion papers that follows this

Progress and status of the Integral Fast Reactor (IFR) development program

Energy Technology Data Exchange (ETDEWEB)

Chang, Yoon I.

1992-04-01

In the Integral Fast Reactor (IFR) development program, the entire reactor system -- reactor, fuel cycle, and waste process is being developed and optimized at the same time as a single integral entity. The ALMR reactor plant design is being developed by an industrial team headed by General Electric and is presented in a companion paper. Detailed discussions on the present status of the IFR technology development activities in the areas of fuels, pyroprocessing, safety, core design, and fuel cycle demonstration are presented in the other two companion papers that follows this.

Progress and status of the Integral Fast Reactor (IFR) development program

Energy Technology Data Exchange (ETDEWEB)

Chang, Yoon I.

1992-01-01

In the Integral Fast Reactor (IFR) development program, the entire reactor system -- reactor, fuel cycle, and waste process is being developed and optimized at the same time as a single integral entity. The ALMR reactor plant design is being developed by an industrial team headed by General Electric and is presented in a companion paper. Detailed discussions on the present status of the IFR technology development activities in the areas of fuels, pyroprocessing, safety, core design, and fuel cycle demonstration are presented in the other two companion papers that follows this.

The current status of utilization of research reactors in China

International Nuclear Information System (INIS)

Luzheng, Yuan

2004-01-01

Seminars on utilization of research reactors were held to enhance experience exchanging among institutes and universities in China. The status of CARR (China Advanced Research Reactor) project is briefly described. The progress in BNCT program in China is introduced. (author)

Status and future plan of nuclear data activities in China

Energy Technology Data Exchange (ETDEWEB)

Zhuang Youxiang; Tang Hongqing [Academia Sinica, Beijing, BJ (China). Inst. of Atomic Energy

1997-03-01

The present status and future plan of nuclear data measurement and evaluation in China are presented, including the supplement, improvement on CENDL-2.1 and benchmark test of CENDL-2.1, the progress on nuclear data measurement and CENDL-3. (author)

Not-for-profit hospitals fight tax-exempt challenges.

Science.gov (United States)

Hudson, T

1990-10-20

The message being sent by local tax boards, state agencies, and the Internal Revenue Service is clear: Not-for-profit hospitals will have to justify their tax-exempt status. But complying with this demand can be a costly administrative burden. Just ask the executives who have been through the experience. CEO Richard Anderson, of St. Luke's Hospital, Bethlehem, PA, is luckier than some executives who have faced tax-exempt challenges. He won his hospital's case. But he still faces a yearly battle: The hospital must prove its compliance annually to the county board of assessors. Other executives report similar experiences. Our cover story takes an in-depth look at how administrators faced challenges to their hospital's tax status and what they learned about their relationship with their communities, as well as a complete state and federal legislative outlook for future developments.

Status of the Medaustron Ion Beam Therapy centre

CERN Document Server

Dorda, U; Osmic, F; Benedikt, M

2012-01-01

MedAustron is a synchrotron based light-ion beam therapy centre for cancer treatment as well as for clinical and non-clinical research currently in its construction phase. The accelerator design is based on the CERN-PIMMS study and its technical implementation by CNAO. This paper presents a status overview over the whole project detailing the achieved progress of the building construction & technical infrastructure installation in Wiener Neustadt, Austria, as well as of the accelerator development, performed at CERN and partially at PSI. The design and procurement status and future planning of the various accelerator components is elaborated.

Status and prospects from the LHC

International Nuclear Information System (INIS)

Hawkings, Richard

2010-01-01

This article reviews the status of the CERN Large Hadron Collider and associated experiments as of July 2010. After a brief discussion of the progress in accelerator and experiment commissioning, the LHC physics landscape is presented, together with a selection of the experimental results achieved so far. Finally the prospects for the 2010-11 LHC physics run are reviewed, with an emphasis on possible discoveries in the Higgs and supersymmetry sectors.

Status of photovoltaic industry in China

International Nuclear Information System (INIS)

Hong Yang; He Wang; Guangde Chen; Huacong Yu; Jianping Xi; Rongqiang Cui

2003-01-01

In recent years, photovoltaic industry has achieved some remarkable development in China, This paper presents a summary and review of the present status of terrestrial photovoltaic industry, and tries to look at possible future scenarios in China, the recent progress with laboratory cells is also discussed. Topics covered include the production equipment, fabrication technology of cells and modules, storage battery, solar charge controller, DC/AC inverter, market and national policy. (Author)

Soil fertility status and challenges in Burundi: an overview

Science.gov (United States)

Kaboneka, Salvator

2015-04-01

Landlocked and thousands miles away from international sea ports, Burundi is one of the poorest country in the world. 58% of the population suffers chronic malnutrition, 67% live in absolute poverty (MDG report 2012). 90% of the estimated 10 million people depends on subsistence agriculture, on about 3 million ha of cultivable land. The average size of a family farm is less than 0.5 ha which has to support a family of typically 7 people . As a consequence, fallow practices are no longer possible and continuous land cultivation leads to enormous soil losses by erosion. As much as 100-200 metric tons per hectare of soil losses have been reported on the hill sides of the Mumirwa region, whose landscape is currently so degraded that the local community now say that "stones grow" in the zone. In medium to high altitude areas, about 1 million of ha are acidic (pH poverty of the population is such that access to fertilizers and adoption of sustainable practices is very weak. We believe that the main challenge to soil productivity in Burundi is more socio-economic than technical, and farmers should be helped with simple tools that should be linked to their indigenous knowledge about soil fertility. Sustainable management of soil fertility is the key challenge for farmers to optimize a sustainable yield. Key words: micro nutrient, soil fertility, nutrient depletion, soil acidity.

Nuclear Explosion Monitoring Advances and Challenges

Science.gov (United States)

Baker, G. E.

2015-12-01

We address the state-of-the-art in areas important to monitoring, current challenges, specific efforts that illustrate approaches addressing shortcomings in capabilities, and additional approaches that might be helpful. The exponential increase in the number of events that must be screened as magnitude thresholds decrease presents one of the greatest challenges. Ongoing efforts to exploit repeat seismic events using waveform correlation, subspace methods, and empirical matched field processing holds as much "game-changing" promise as anything being done, and further efforts to develop and apply such methods efficiently are critical. Greater accuracy of travel time, signal loss, and full waveform predictions are still needed to better locate and discriminate seismic events. Important developments include methods to model velocities using multiple types of data; to model attenuation with better separation of source, path, and site effects; and to model focusing and defocusing of surface waves. Current efforts to model higher frequency full waveforms are likely to improve source characterization while more effective estimation of attenuation from ambient noise holds promise for filling in gaps. Censoring in attenuation modeling is a critical problem to address. Quantifying uncertainty of discriminants is key to their operational use. Efforts to do so for moment tensor (MT) inversion are particularly important, and fundamental progress on the statistics of MT distributions is the most important advance needed in the near term in this area. Source physics is seeing great progress through theoretical, experimental, and simulation studies. The biggest need is to accurately predict the effects of source conditions on seismic generation. Uniqueness is the challenge here. Progress will depend on studies that probe what distinguishes mechanisms, rather than whether one of many possible mechanisms is consistent with some set of observations.

AECL's progress in developing the DUPIC fuel fabrication process

International Nuclear Information System (INIS)

Sullivan, J.D.; Cox, D.S.

1995-01-01

Spent Pressurized Water Reactor (PWR) fuel can be used directly in CANDU reactors without the need for wet chemical reprocessing or reenrichment. Considerable experimental progress has been made in verifying the practicality of this fuel cycle, including hot-cell experiments using spent PWR fuels and out-cell trials using surrogate fuels. This paper describes the current status of these experiments. (author)

Seismic damage estimation for buried pipelines - challenges after three decades of progress

Energy Technology Data Exchange (ETDEWEB)

Pineda-porras, Omar Andrey [Los Alamos National Laboratory; Najafi, Mohammand [U. OF TEXAS

2009-01-01

This paper analyzes the evolution over the past three decades of seismic damage estimation for buried pipelines and identifies some challenges for future research studies on the subject. The first section of this paper presents a chronological description of the evolution since the mid-1970s of pipeline fragility relations - the most common tool for pipeline damage estimation - and follows with a careful analysis of the use of several ground motion parameters as pipeline damage indicators. In the second section of the paper, four gaps on the subject are identified and proposed as challenges for future research studies. The main conclusion of this work is that enhanced fragility relations must be developed for improving pipeline damage estimation, which must consider relevant parameters that could influence the seismic response of pipelines.

Challenges for extension service to render efficient post-transformer ...

African Journals Online (AJOL)

Ben Stevens

series of ten country papers that sought to assess and benchmark common challenges linked ... Province of South Africa (gender, marital status, educational qualifications .... Standard of extension in South Africa (Norms and Standards, 2005).

Elimination of Guinea Worm Disease in Ethiopia; Current Status of the Disease's, Eradication Strategies and Challenges to the End Game.

Science.gov (United States)

Beyene, Habtamu Bedimo; Bekele, Abyot; Shifara, Amanu; Ebstie, Yehenew A; Desalegn, Zelalem; Kebede, Zeyede; Mulugeta, Abate; Deribe, Kebede; Tadesse, Zerihun; Abebe, Tamrat; Kebede, Biruck; Abrha, Getaneh; Jima, Daddi

2017-01-01

Dracunculiasis, also named Guinea Worm Disease (GWD), is one of the Neglected Tropical Diseases (NTDs) caused by a parasitic nematode known as Dracunculus medinensis and has been known since antiquity as 'fiery serpent' from Israelites. It is transmitted to humans via drinking contaminated water containing infective copepods. Given, its feasibility for eradication, the Guinea Worm Eradication Program (GWEP) was launched in 1980 with the aim of eradicating the disease. Since its inception, GWEP has made an extraordinary progress in interrupting transmission. Globally, the number of reported cases reduced from 3.5 million in 20 countries in 1986 to only 22 cases in 2015 from only four countries namely South Sudan, Mali, Chad and Ethiopia. Since Mali has interrupted transmission of GWD in 2016, currently, the disease remains endemic in only three sub-Saharan African countries namely, South Sudan, Chad and Ethiopia. Each endemic country has its own national Guinea Worm Eradication Program. In Ethiopia, the Ethiopian Dracunculiasis Eradication Program (EDEP) which was established in 1993 has made remarkable move towards interruption of disease transmission and now the endgame is fast approaching. The EDEP with support mainly from The Carter Center, WHO, and UNICEF has reduced GWD by more than 99% from 1994 to 2015. In 2015, only 3 indigenous cases in humans and 14 in animals (13 in dogs and 1 in baboon) were reported. In 2016, 3 human cases, 14 dogs and 2 baboon infections were reported.. Refugee influx from the Republic of South Sudan (RSS), increased animal infections with unknown role in transmission of Dracunculiasis, the presence of hard to reach communities and lack of safe water sources in remote non-village areas remain among important challenges at this final stage of GWD eradication in Ethiopia. This paper reviews progress made towards Guinea Worm Eradication with a focus on the experience of the Ethiopian Dracunculiasis Eradication Program (EDEP), and

Experimental nuclear physics at Vanderbilt University. Progress report, August, 1983-August, 1984

International Nuclear Information System (INIS)

Hamilton, J.H.

1984-01-01

Progress summaries are given in the fields of in-beam gamma ray spectroscopy, nuclei far from stability, nuclear reaction mechanism studies, delta-electron spectroscopy, theoretical studies, and other research and activities. Status of the Joint Institute for Heavy Ion Research is reviewed

Status of the breeder fuel cycle in the United States

International Nuclear Information System (INIS)

Burch, W.D.

1985-01-01

This paper reviews the status and plans for the fast reactor fuel cycle in the United States. The United States is undertaking a complete reexamination of its entire breeder program strategy, and the direction of the new program is not yet clear. Studies in progress to examine the associated fuel cycle strategies as they relate to the overall emerging breeder strategy are described. The present status of and recent developments in the fuel cycle R and D programs are summarized