WorldWideScience

Sample records for stage gaging system

  1. Versatile radiation gaging system

    International Nuclear Information System (INIS)

    Long, P.J.

    1978-01-01

    The attributes of computerized versatile radiation gaging systems are described. The gages are used to measure plating thicknesses and material characteristics that can be determined from radiation attenuation and/or x-ray fluorescence measurements

  2. Heat-Flux Gage thermophosphor system

    Energy Technology Data Exchange (ETDEWEB)

    Tobin, K.W.

    1991-08-01

    This document describes the installation, hardware requirements, and application of the Heat-Flux Gage (Version 1.0) software package developed by the Oak Ridge National Laboratory, Applied Technology Division. The developed software is a single component of a thermographic phosphor-based temperature and heat-flux measurement system. The heat-flux transducer was developed by EG G Energy Measurements Systems and consists of a 1- by 1-in. polymethylpentene sheet coated on the front and back with a repeating thermographic phosphor pattern. The phosphor chosen for this application is gadolinium oxysulphide doped with terbium. This compound has a sensitive temperature response from 10 to 65.6{degree}C (50--150{degree}F) for the 415- and 490-nm spectral emission lines. 3 refs., 17 figs.

  3. Low Cost Stream Gaging through Analysis of Stage Height Using Digital Photography

    Science.gov (United States)

    Mui, C. K.; Royem, A. A.; Walter, M. T.

    2010-12-01

    Through the middle of the twentieth century, the US was relatively rich in active streamflow gages. Over the past four decades, the number of gages has decreased by approximately 10% (approx. 20 gages a year) and it is likely this trend will continue for the foreseeable future. Not only are streaflow data valuable for water resources planning and management, but they are invaluable for assessing how land use and climate changes are impacting the environment. Affordable, easy-to-use systems need to be developed to enable a wider community to establish and maintain streamflow observation sites. Currently USGS-like gauges cost 30,000 to 50,000 to build and $6,000/year to maintain. We are developing a system that uses digital images in conjunction with MATLAB for image post processing that has the potential to both accurately and cost effectively monitor stream gauge. We explored several different staff gauge designs in conjunction with associated image processing code. The most robust design so far consists of a brightly colored metal staff gauge and and code that allows a point-and-click method for training the image processing code to correctly identify the staff. We ultimately envision a system in which users can upload their images via the Internet and post-processing is done on a remote server, which also collates data and metadata for open-access downloading.

  4. Stress-Gage System for the Megabar (100 GPa) Range

    Science.gov (United States)

    1976-06-01

    interface, using available Hugoniot data. With one exception, a fused silica gage package, Vistal (a fully dense Al203 ceramic) was used as the gage...package material in the calibration experiments. Z Although no Hugoniot measurements have been reported for Vistal , per so, one may note that Ifugoniot...Hiugoniot adequately represents the Vistal Hugoniot. The base-plate materials used were OFHC copper and 2024 T-6 .alminm, chosen because their

  5. 49 CFR 213.110 - Gage restraint measurement systems.

    Science.gov (United States)

    2010-10-01

    ...). c=Coefficient of friction between rail/tie which is assigned a nominal value of (0.4). V=Actual... test will not be considered valid until contact with these components is restored under static loading... wheelset. (4) Load severity means the amount of lateral load applied to the fastener system after friction...

  6. Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma.

    Science.gov (United States)

    Gjerstorff, Morten F; Pøhl, Mette; Olsen, Karen E; Ditzel, Henrik J

    2013-10-08

    The unique expression pattern and immunogenic properties of cancer/testis antigens make them ideal targets for immunotherapy of cancer. The MAGE-A3 cancer/testis antigen is frequently expressed in non-small cell lung cancer (NSCLC) and vaccination with MAGE-A3 in patients with MAGE-A3-positive NSCLC has shown promising results. However, little is known about the expression of other cancer/testis antigens in NSCLC. In the present study the expression of cancer/testis antigens GAGE, NY-ESO-1 and SP17 was investigated in patients with completely resected, early stage, primary NSCLC. Tumor biopsies from normal lung tissue and from a large cohort (n = 169) of NSCLC patients were examined for GAGE, NY-ESO-1 and SP17 protein expression by immunohistochemical analysis. The expression of these antigens was further matched to clinical and pathological features using univariate cox regression analysis. GAGE and NY-ESO-1 cancer/testis antigens were not expressed in normal lung tissue, while SP17 was expressed in ciliated lung epithelia. The frequency of GAGE, NY-ESO-1 and SP17 expression in NSCLC tumors were 26.0% (44/169), 11.8% (20/169) and 4.7% (8/169), respectively, and 33.1% (56/169) of the tumors expressed at least one of these antigens. In general, the expression of GAGE, NY-ESO-1 and SP17 was not significantly associated with a specific histotype (adenocarcinoma vs. squamous cell carcinoma), but high-level GAGE expression (>50%) was more frequent in squamous cell carcinoma (p = 0.02). Furthermore, the frequency of GAGE expression was demonstrated to be significantly higher in stage II-IIIa than stage I NSCLC (17.0% vs. 35.8%; p = 0.02). Analysis of the relation between tumor expression of GAGE and NY-ESO-1 and survival endpoints revealed no significant associations. Our study demonstrates that GAGE, NY-ESO-1 and SP17 cancer/testis antigens are candidate targets for immunotherapy of NSCLC and further suggest that multi-antigen vaccines may be beneficial.

  7. Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma

    DEFF Research Database (Denmark)

    Gjerstorff, Morten F; Pøhl, Mette; Olsen, Karen E

    2013-01-01

    NSCLC has shown promising results. However, little is known about the expression of other cancer/testis antigens in NSCLC. In the present study the expression of cancer/testis antigens GAGE, NY-ESO-1 and SP17 was investigated in patients with completely resected, early stage, primary NSCLC....

  8. Strain-gage signal-conditioning system for use in the LCP

    International Nuclear Information System (INIS)

    Ellis, J.F.; Walstrom, P.L.

    1979-01-01

    A strain-gage signal-conditioning system, providing wide-band noise rejection and isolation from high voltages that occur during emergency coil discharges, has been developed and tested. The multichannel system combines double-shielded transformers, neutralizing networks, and bandpass filters (with commercial 3-kHz carrier amplifier modules to isolate the strain gages to 5000 V) eliminate thermoelectric effects, and provide a signal bandwidth of 200 Hz. Common-mode interference occurs primarily as a result of beat-note effects between the carrier and the superimposed noise at frequencies near the odd harmonics of the carrier. The common-mode rejection of the test circuit was measured to be 120 dB for noise at 2750 and 3250 Hz, 135 dB at 3 kHz, and 135 dB and better at the odd harmonics of 9 kHz and above. The system has been successfully used in strain measurements on the toroidal field coils of the ISX-B tokamak and will be used in the Large Coil Test Facility to monitor strains in the energized coil conductors

  9. Creep testing of foil-gage metals at elevated temperature using an automated data acquisition system

    Science.gov (United States)

    Blackburn, L. B.

    1983-01-01

    A method is being developed to obtain creep data on foil gage metals at elevated temperatures using an automated data acquisition system in conjunction with a mechanically counter balanced extensometer. The automated system components include the Hewlett-Packard (HP) 9845A desktop computer, the HP 3455A digital voltmeter and the HP 3495A scanner. Software for test monitoring and data collection was developed; data manipulation, including curve plotting was done with a HP regression analysis software package. Initial creep tests were conducted on .003 in. thick foil specimens of Ti-6A1-4V at temperatures of 800 F and 1000 F and at stress levels of 25 ksi and 45 ksi. For comparison, duplicate tests were run on .049 in. thick specimens sheet of the same alloy. During testing, the furnace and specimen temperature, bridge voltage, strain and load output were automatically monitored and recorded at predetermined intervals. Using the HP regression analysis program, recorded strain output was plotted as a function of time. These resultant creep curves indicate that, under similar conditions of temperature and stress, foil gage specimens exhibit a higher creep rate than sheet specimens.

  10. Streamflow Gaging Stations

    Data.gov (United States)

    Department of Homeland Security — This map layer shows selected streamflow gaging stations of the United States, Puerto Rico, and the U.S. Virgin Islands, in 2013. Gaging stations, or gages, measure...

  11. Error Analysis of the Shuttle Orbital Maneuvering System P-V-T Propellant Gaging Module. Mission Planning, Mission Analysis and Software Formulation

    Science.gov (United States)

    Duhon, D. D.

    1975-01-01

    An investigation of the shuttle orbital maneuvering system (OMS) pressure-volume-temperature (P-V-T) propellant gaging module has revealed that the gaging errors due to the combined effects of random instrumentation measurement errors, propellant loading uncertainties, and simplifying assumptions in the software are non-linear over the range of the usable propellant quantity gage (0-100%), with the largest error being at the zero point. When the OMS propellant tanks in the orbiter vehicle pods are filled to contain 100% of the maximum usable propellant, the gaging error at the zero point was determined to be 9.5% for the fuel and 9.5% for the oxidizer. When the OMS propellant tanks initially contain 50% of the maximum usable propellant, the largest gaging error is still 9.5% for the fuel and 9.5% for the oxidizer.

  12. Commonality Study of the Pressure-Volume-Temperature Based Propellant Gaging Software Modules for the Auxiliary Power Unit, Reaction Control System, and Orbital Maneuvering System

    Science.gov (United States)

    Duhon, D. D.

    1975-01-01

    Computer storage requirements can be reduced if areas of commonality exist in two or more programs placed in the same computer and identical code can be used by more than one program. The pressure-volume-temperature (P-V-T) relationship for the propellant tank pressurant agent is utilized as the basis for either a primary of a backup propellant gaging program for the auxiliary power unit (APU), the reaction control system (RCS), and the orbital maneuvering system (OMS). These three propellant gaging programs were investigated. It was revealed that a very limited degree of software commonality exits among them. An examination of this common software indicated that only the computation of the helium compressibility factor in an external function subprogram accessible to both the RCS and OMS propellant gaging programs appears to offer a savings in computer storage requirements.

  13. Assessment of current high-temperature strain gages

    International Nuclear Information System (INIS)

    Smith, J.E.

    1979-12-01

    Long-term stability tests for systematic drift and strain sensitivity (gage factor) were conducted on two types of capacitive strain gages - the Boeing differential-capacitance gage and the CERL-Planer variable gap capacitive strain transducer - and on the Ailtech SG-425 resistance gage. Results for tests of durations up to 12,000 hr are presented and compared with similar tests reported by others. The stability and repeatability of the capacitive systems were verified. In addition, two short-term investigations were made on Ailtech weldable-resistance gages to address areas of uncertainty related to special applications. Data from these tests are also presented and interpreted. Advantages and limitations of the various systems are identified, and conclusions and recommendations are presented. Descriptions of the gage systems and problems encountered in the use of capacitive gages are given in appendices

  14. Metadata management staging system

    Energy Technology Data Exchange (ETDEWEB)

    2013-08-01

    Django application providing a user-interface for building a file and metadata management system. An evolution of our Node.js and CouchDb metadata management system. This one focuses on server functionality and uses a well-documented, rational and REST-ful API for data access.

  15. Staged membrane oxidation reactor system

    Science.gov (United States)

    Repasky, John Michael; Carolan, Michael Francis; Stein, VanEric Edward; Chen, Christopher Ming-Poh

    2012-09-11

    Ion transport membrane oxidation system comprising (a) two or more membrane oxidation stages, each stage comprising a reactant zone, an oxidant zone, one or more ion transport membranes separating the reactant zone from the oxidant zone, a reactant gas inlet region, a reactant gas outlet region, an oxidant gas inlet region, and an oxidant gas outlet region; (b) an interstage reactant gas flow path disposed between each pair of membrane oxidation stages and adapted to place the reactant gas outlet region of a first stage of the pair in flow communication with the reactant gas inlet region of a second stage of the pair; and (c) one or more reactant interstage feed gas lines, each line being in flow communication with any interstage reactant gas flow path or with the reactant zone of any membrane oxidation stage receiving interstage reactant gas.

  16. New constraints on slip rates and locking depths of the San Andreas Fault System from Sentinel-1A InSAR and GAGE GPS observations

    Science.gov (United States)

    Ward, L. A.; Smith-Konter, B. R.; Higa, J. T.; Xu, X.; Tong, X.; Sandwell, D. T.

    2017-12-01

    After over a decade of operation, the EarthScope (GAGE) Facility has now accumulated a wealth of GPS and InSAR data, that when successfully integrated, make it possible to image the entire San Andreas Fault System (SAFS) with unprecedented spatial coverage and resolution. Resulting surface velocity and deformation time series products provide critical boundary conditions needed for improving our understanding of how faults are loaded across a broad range of temporal and spatial scales. Moreover, our understanding of how earthquake cycle deformation is influenced by fault zone strength and crust/mantle rheology is still developing. To further study these processes, we construct a new 4D earthquake cycle model of the SAFS representing the time-dependent 3D velocity field associated with interseismic strain accumulation, co-seismic slip, and postseismic viscoelastic relaxation. This high-resolution California statewide model, spanning the Cerro Prieto fault to the south to the Maacama fault to the north, is constructed on a 500 m spaced grid and comprises variable slip and locking depths along 42 major fault segments. Secular deep slip is prescribed from the base of the locked zone to the base of the elastic plate while episodic shallow slip is prescribed from the historical earthquake record and geologic recurrence intervals. Locking depths and slip rates for all 42 fault segments are constrained by the newest GAGE Facility geodetic observations; 3169 horizontal GPS velocity measurements, combined with over 53,000 line-of-sight (LOS) InSAR velocity observations from Sentinel-1A, are used in a weighted least-squares inversion. To assess slip rate and locking depth sensitivity of a heterogeneous rheology model, we also implement variations in crustal rigidity throughout the plate boundary, assuming a coarse representation of shear modulus variability ranging from 20-40 GPa throughout the (low rigidity) Salton Trough and Basin and Range and the (high rigidity) Central

  17. Operation of staged membrane oxidation reactor systems

    Science.gov (United States)

    Repasky, John Michael

    2012-10-16

    A method of operating a multi-stage ion transport membrane oxidation system. The method comprises providing a multi-stage ion transport membrane oxidation system with at least a first membrane oxidation stage and a second membrane oxidation stage, operating the ion transport membrane oxidation system at operating conditions including a characteristic temperature of the first membrane oxidation stage and a characteristic temperature of the second membrane oxidation stage; and controlling the production capacity and/or the product quality by changing the characteristic temperature of the first membrane oxidation stage and/or changing the characteristic temperature of the second membrane oxidation stage.

  18. GAGES-II: Geospatial Attributes of Gages for Evaluating Streamflow

    Science.gov (United States)

    Falcone, James A.

    2011-01-01

    This dataset, termed "GAGES II", an acronym for Geospatial Attributes of Gages for Evaluating Streamflow, version II, provides geospatial data and classifications for 9,322 stream gages maintained by the U.S. Geological Survey (USGS). It is an update to the original GAGES, which was published as a Data Paper on the journal Ecology's website (Falcone and others, 2010b) in 2010. The GAGES II dataset consists of gages which have had either 20+ complete years (not necessarily continuous) of discharge record since 1950, or are currently active, as of water year 2009, and whose watersheds lie within the United States, including Alaska, Hawaii, and Puerto Rico. Reference gages were identified based on indicators that they were the least-disturbed watersheds within the framework of broad regions, based on 12 major ecoregions across the United States. Of the 9,322 total sites, 2,057 are classified as reference, and 7,265 as non-reference. Of the 2,057 reference sites, 1,633 have (through 2009) 20+ years of record since 1950. Some sites have very long flow records: a number of gages have been in continuous service since 1900 (at least), and have 110 years of complete record (1900-2009) to date. The geospatial data include several hundred watershed characteristics compiled from national data sources, including environmental features (e.g. climate – including historical precipitation, geology, soils, topography) and anthropogenic influences (e.g. land use, road density, presence of dams, canals, or power plants). The dataset also includes comments from local USGS Water Science Centers, based on Annual Data Reports, pertinent to hydrologic modifications and influences. The data posted also include watershed boundaries in GIS format. This overall dataset is different in nature to the USGS Hydro-Climatic Data Network (HCDN; Slack and Landwehr 1992), whose data evaluation ended with water year 1988. The HCDN identifies stream gages which at some point in their history had

  19. Ball mounting fixture for a roundness gage

    Science.gov (United States)

    Gauler, A.L.; Pasieka, D.F.

    1983-11-15

    A ball mounting fixture for a roundness gage is disclosed. The fixture includes a pair of chuck assemblies oriented substantially transversely with respect to one another and mounted on a common base. Each chuck assembly preferably includes a rotary stage and a wobble plate affixed thereto. A ball chuck affixed to each wobble plate is operable to selectively support a ball to be measured for roundness, with the wobble plate permitting the ball chuck to be tilted to center the ball on the axis of rotation of the rotary stage. In a preferred embodiment, each chuck assembly includes a vacuum chuck operable to selectively support the ball to be measured for roundness. The mounting fixture enables a series of roundness measurements to be taken with a conventional rotating gagehead roundness instrument, which measurements can be utilized to determine the sphericity of the ball. 6 figs.

  20. Control of stage by stage changing linear dynamic systems

    Directory of Open Access Journals (Sweden)

    Barseghyan V.R.

    2012-01-01

    Full Text Available In this paper, the control problems of linear dynamic systems stage by stage changing and the optimal control with the criteria of quality set for the whole range of time intervals are considered. The necessary and sufficient conditions of total controllability are also stated. The constructive solving method of a control problem is offered, as well as the definitions of conditions for the existence of programmed control and motions. The explicit form of control action for a control problem is constructed. The method for solving optimal control problem is offered, and the solution of optimal control of a specific target is brought.

  1. Comparison of new AJCC staging system with old AJCC staging system in nasopharyngeal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Se Mie; Wu, Hong Gyun; Park, Charn II [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    2000-12-01

    This study was designed to examine the reliability of the new version of the AJCC staging system (1997) of nasopharyngeal carcinoma in comparison with the AJCC staging system of 1992. Between 1983 and 1996, 185 patients with histologically proven nasopharyngeal carcinoma were treated with radiation therapy at the Department of Therapeutic Radiology Seoul National University Hospital. For these patients, AJCC staging system of 1992 was compared with the 1997 version, by reviewing hospital records, computed tomography (CT) and/or magnetic resonance imaging (MRI). 5-year overall survival rates according to the 1992 and 1997 AJCC staging systems were 100%, and 100% at stage I; 100%, and 68.8% at stage ll;61.4%, and 63.8% at stage III; 61.1%, and 63.2% at stage IV. 5-year overall survival rates of each classification showed significant differences between stages (p=0.0049 for the old version, p=0.01 for the new), but no significant difference was found between the staging systems except at stage II. The new AJCC staging system allows staging as reliably as the 1992 version, but the adequacy of the newly modified staging classification should be confirmed by further clinical examination.

  2. Apparatus for storage, retrieval and deployment of drag gages used in fuel assembly inspection

    International Nuclear Information System (INIS)

    Bova, I.N.; Kalkbrenner, R.W.; Leumann, H.E.

    1987-01-01

    In a fuel assembly guide thimble inspecting system having drag gages being insertable within guide thimbles of a fuel assembly, a drag gage handling apparatus is described comprising: (a) storing means for holding the drag gages in a series of storage positions being angularly displaced from one another about a common axis; (b) means for moving the drag gages from the respective storage positions about an endless path to dispose a selected one of the gages at a retrieval-and-return station; (c) loading means operable for respectively gripping and releasing the selected one drag gage at the retrieval-and-return station; (d) transporting means movable between a work station and a storage station; (e) hoisting means supporting the loading means and being supported by the transporting means, the hoisting means being operable for respectively raising and lowering the loading means and the selected one drag gage therewith away from and toward the retrieval-and-return station when the transporting means is at the storage station and operable for respectively raising and lowering the loading means and the selected one drag gage away from and toward the fuel assembly guide thimbles when the transporting means is at the work station; (f) safety means releasably mounted to the loading means for restraining the loading means in gripping relation with the selected one drag gage; and (g) means located adjacent to the retrieval-and-return station for releasing the safety means from restraining the loading means in gripping relation with the selected one drag gage only when the loading means and selected one drag gage are disposed at the retrieval-and-return station

  3. Gage for measuring coastal erosion and sedimentation

    Science.gov (United States)

    Carpini, T. D.; Moughon, W. C.

    1970-01-01

    Underwater sand height gage, which measures heights up to 12 inches, is comprised of two standard flush-diaphragm pressure transducers. Gage is very sensitive to buried water heights and is useful as a research tool in study of wet earth and landslide phenomena.

  4. Properties of strain gages at cryogenic temperature

    International Nuclear Information System (INIS)

    Shibata, Nobuo; Fujiyoshi, Toshimitsu.

    1978-01-01

    At the time of developing superconduction generators, the stress measurement for rotor parts is required to grasp the safety and performance of the rotor at cryogenic temperature, which is cooled with liquid helium. In case of carrying out the stress measurement with strain gages, the problems are as follows. The strain gages and lead wires are exposed to cryogenic temperature from 4 to 10 K and strong magnetic field of about 3T, and subjected to high centrifugal acceleration of about 500G. In order to establish the techniques of the stress measurement under such conditions, the adhesives and damp-proof coatings for strain gages and strain gages themselves in Japan and foreign countries were examined on the properties at cryogenic temperature. As for the properties of strain gages, mainly the apparent strain owing to temperature change was investigated, and the change of the gage factors was studies only at liquid nitrogen temperature. The stress measurement with strain gages at low temperature had been studied in detail down to liquid nitrogen temperature concerning LNG tanks. The experimental apparatus, the samples, the testing methods and the test results of cooling tests on adhesives and damp-proof coatings, and the temperature characteristics of strain gages are reported. The usable adhesives and coatings were found, and correction by accurate temperature measurement is required for apparent strain. (Kako, I.)

  5. Non-metallic gage for gap

    International Nuclear Information System (INIS)

    Hiroki, Hideo.

    1996-01-01

    The present invention concerns a non-metallic gage for detecting a gap which can not be seen from the out side such as a gap between a water pipe and fuel rods without damaging an objective material as to whether the gap is formed within a standard value or not. The gage is made of a synthetic resin, for example, polyacetal having such a hardness as not damaging the objective material and endurable to repeating flexure upon use. The gage comprises a short gage portion having a predetermined standard thickness and an flexible extended connection portion reduced in the thickness. Provision of the extended connection portion enables wide range flexure thereof such as ±60deg relative to insertion direction during insertion operation upon testing to solve a drawback in the prior art such as worry of breakage of the gage, thereby enabling to conduct inspection rapidly at high reliability. (N.H.)

  6. Space Launch System Upper Stage Technology Assessment

    Science.gov (United States)

    Holladay, Jon; Hampton, Bryan; Monk, Timothy

    2014-01-01

    The Space Launch System (SLS) is envisioned as a heavy-lift vehicle that will provide the foundation for future beyond low-Earth orbit (LEO) exploration missions. Previous studies have been performed to determine the optimal configuration for the SLS and the applicability of commercial off-the-shelf in-space stages for Earth departure. Currently NASA is analyzing the concept of a Dual Use Upper Stage (DUUS) that will provide LEO insertion and Earth departure burns. This paper will explore candidate in-space stages based on the DUUS design for a wide range of beyond LEO missions. Mission payloads will range from small robotic systems up to human systems with deep space habitats and landers. Mission destinations will include cislunar space, Mars, Jupiter, and Saturn. Given these wide-ranging mission objectives, a vehicle-sizing tool has been developed to determine the size of an Earth departure stage based on the mission objectives. The tool calculates masses for all the major subsystems of the vehicle including propellant loads, avionics, power, engines, main propulsion system components, tanks, pressurization system and gases, primary structural elements, and secondary structural elements. The tool uses an iterative sizing algorithm to determine the resulting mass of the stage. Any input into one of the subsystem sizing routines or the mission parameters can be treated as a parametric sweep or as a distribution for use in Monte Carlo analysis. Taking these factors together allows for multi-variable, coupled analysis runs. To increase confidence in the tool, the results have been verified against two point-of-departure designs of the DUUS. The tool has also been verified against Apollo moon mission elements and other manned space systems. This paper will focus on trading key propulsion technologies including chemical, Nuclear Thermal Propulsion (NTP), and Solar Electric Propulsion (SEP). All of the key performance inputs and relationships will be presented and

  7. Discharge measurements at gaging stations

    Science.gov (United States)

    Turnipseed, D. Phil; Sauer, Vernon B.

    2010-01-01

    The techniques and standards for making discharge measurements at streamflow gaging stations are described in this publication. The vertical axis rotating-element current meter, principally the Price current meter, has been traditionally used for most measurements of discharge; however, advancements in acoustic technology have led to important developments in the use of acoustic Doppler current profilers, acoustic Doppler velocimeters, and other emerging technologies for the measurement of discharge. These new instruments, based on acoustic Doppler theory, have the advantage of no moving parts, and in the case of the acoustic Doppler current profiler, quickly and easily provide three-dimensional stream-velocity profile data through much of the vertical water column. For much of the discussion of acoustic Doppler current profiler moving-boat methodology, the reader is referred to U.S. Geological Survey Techniques and Methods 3-A22 (Mueller and Wagner, 2009). Personal digital assistants (PDAs), electronic field notebooks, and other personal computers provide fast and efficient data-collection methods that are more error-free than traditional hand methods. The use of portable weirs and flumes, floats, volumetric tanks, indirect methods, and tracers in measuring discharge are briefly described.

  8. Fibre-Optic Semiconductor Temperature Gage

    Science.gov (United States)

    Sharma, M.

    1982-01-01

    "Safe" temperature gage for explosive liquids is based on optical transmission. Semiconductor crystal inserted between input and output optical fibers is temperature-sensing element in a new approach to measuring temperature of cryogens. Since no electrical components are immersed in liquid, new sensor minimizes danger of electrically ignited explosions in hazardous cryogens such as oxygen and hydrogen. Gage also useful for handling noncryogenic liquids in aircraft, automobiles, boats and water tanks.

  9. A simplified staging system based on the radiological findings in different stages of ochronotic spondyloarthropathy

    International Nuclear Information System (INIS)

    Jebaraj, Isaac; Chacko, Binita Riya; Chiramel, George Koshy; Matthai, Thomas; Parameswaran, Apurve

    2013-01-01

    This study describes a group of 26 patients with ochronotic spondyloarthropathy who were on regular treatment and follow-up at a tertiary level hospital and proposes a simplified staging system for ochronotic spondyloarthropathy based on radiographic findings seen in the thoracolumbar spine. This proposed classification makes it easy to identify the stage of the disease and start the appropriate management at an early stage. Four progressive stages are described: an inflammatory stage (stage 1), the stage of early discal calcification (stage 2), the stage of fibrous ankylosis (stage 3), and the stage of bony ankylosis (stage 4). To our knowledge, this is the largest reported series of radiological description of spinal ochronosis, and emphasizes the contribution of the spine radiograph in the diagnosis and staging of the disease

  10. High-Temperature Extensometry and PdCr Temperature-Compensated Wire Resistance Strain Gages Compared

    Science.gov (United States)

    1997-01-01

    A detailed experimental evaluation is underway at the NASA Lewis Research Center to compare and contrast the performance of the PdCr/Pt dual-element temperature-compensated wire resistance strain gage with that of conventional high-temperature extensometry. The advanced PdCr gage, developed by researchers at Lewis, exhibits desirable properties and a relatively small and repeatable apparent strain to 800 C. This gage represents a significant advance in technology because existing commercial resistance strain gages are not reliable for quasi-static strain measurements above approx. 400 C. Various thermal and mechanical loading spectra are being applied by a high-temperature thermomechanical uniaxial testing system to evaluate the two strain-measurement systems. This is being done not only to compare and contrast the two strain sensors, but also to investigate the applicability of the PdCr strain gage to the coupon-level specimen testing environment typically employed when the high-temperature mechanical behavior of structural materials is characterized. Strain measurement capabilities to 800 C are being investigated with a nickel-base superalloy, Inconel 100 (IN 100), substrate material and application to TMC's is being examined with the model system, SCS-6/Ti-15-3. Furthermore, two gage application techniques are being investigated in the comparison study: namely, flame-sprayed and spot welding. The apparent strain responses of both the weldable and flame-sprayed PdCr wire strain gages were found to be cyclically repeatable on both IN 100 and SCS-6/Ti-15-3 [0]_8. In general, each gage exhibited some uniqueness with respect to apparent strain behavior. Gages mounted on the IN 100 specimens tended to show a repeatable apparent strain within the first few cycles, because the thermal response of IN 100 was stable. This was not the case, however, for the TMC specimens, which typically required several thermal cycles to stabilize the thermal strain response. Thus

  11. A siphon gage for monitoring surface-water levels

    Science.gov (United States)

    McCobb, T.D.; LeBlanc, D.R.; Socolow, R.S.

    1999-01-01

    A device that uses a siphon tube to establish a hydraulic connection between the bottom of an onshore standpipe and a point at the bottom of a water body was designed and tested for monitoring surface-water levels. Water is added to the standpipe to a level sufficient to drive a complete slug of water through the siphoning tube and to flush all air out of the system. The water levels in the standpipe and the water body equilibrate and provide a measurable static water surface in the standpipe. The siphon gage was designed to allow quick and accurate year-round measurements with minimal maintenance. Currently available devices for monitoring surface-water levels commonly involve time-consuming and costly installation and surveying, and the movement of reference points and the presence of ice cover in cold regions cause discontinuity and inaccuracy in the data collected. Installation and field testing of a siphon gage using 0.75-in-diameter polyethylene tubing at Ashumet Pond in Falmouth, Massachusetts, demonstrated that the siphon gage can provide long-term data with a field effort and accuracy equivalent to measurement of ground-water levels at an observation well.A device that uses a siphon tube to establish a hydraulic connection between the bottom of an onshore standpipe and a point at the bottom of a water body was designed and tested for monitoring surface-water levels. Water is added to the standpipe to a level sufficient to drive a complete slug of water through the siphoning tube and to flush all air out of the system. The water levels in the standpipe and the water body equilibrate and provide a measurable static water surface in the standpipe. The siphon gage was designed to allow quick and accurate year-round measurements with minimal maintenance. Currently available devices for monitoring surface-water levels commonly involve time-consuming and costly installation and surveying, and the movement of reference points and the presence of ice cover in cold

  12. Technology and staging effects on two-stage-to-orbit systems

    Science.gov (United States)

    Wilhite, Alan W.

    1991-01-01

    Horizontal takeoff and landing two-stage systems with an airbreathing first stage and rocket second stage are evaluated for staging Mach numbers that range from 5 to 14. All systems are evaluated with advanced technologies being developed in the NASP Program and sized to the same mission requirements. With these advanced technologies, the two-stage systems are heavier than the single stage. The weights of the two-stage systems are closely related to staging. Using a rocket on the first stage to accelerate from the turboramjet limit of Mach 6 to Mach 10 signiificantly decreases dry weight as compared to the Mach 6-staged system. The optimum dry weight staging Mach number for the scramjet two-stage system is Mach 12. At a 40 percent weight growth (current technology level), the scramjet two-stage systems are half the weight and less sensitive to weight changes than the single stage, but still require substantial technology development in the areas of inlets, nozzles, ramjet propulsion, active cooling, and high-temperature structures.

  13. Stages in the energetics of baroclinic systems

    Science.gov (United States)

    Orlanski, Isidoro; Sheldon, John P.

    1995-10-01

    The results from several idealized and case studies are drawn together to form a comprehensive picture of "downstream baroclinic evolution" using local energetics. This new viewpoint offers a complementary alternative to the more conventional descriptions of cyclone development. These additional insights are made possible largely because the local energetics approach permits one to define an energy flux vector which accurately describes the direction of energy dispersion and quantifies the role of neighboring systems in local development. In this view, the development of a system's energetics is divided into three stages. In Stage 1, a pre-existing disturbance well upstream of an incipient trough loses energy via ageostrophic geopotential fluxes directed downstream through the intervening ridge, generating a new energy center there. In Stage 2, this new energy center grows vigorously, at first due to the convergence of these fluxes, and later by baroclinic conversion as well. As the center matures, it begins to export energy via geopotential fluxes to the eastern side of the trough, initiating yet another energy center. In Stage 3, this new energy center continues to grow while that on the western side of the trough decays due to a dwinding supply of energy via fluxes from the older upstream system and also as a consequence of its own export of energy downstream. As the eastern energy center matures, it exports energy further downstream, and the sequence begins anew. The USA "Blizzard of'93" is used as a new case study to test the limits to which this conceptual sequence might apply, as well as to augment the current limited set of case studies. It is shown that, despite the extraordinary magnitude of the event, the evolution of the trough associated with the Blizzard fits the conceptual picture of downstream baroclinic evolution quite well, with geopotential fluxes playing a critical rôle in three respects. First, fluxes from an old, decaying system in the

  14. MAGE, BAGE and GAGE gene expression in human rhabdomyosarcomas.

    Science.gov (United States)

    Dalerba, P; Frascella, E; Macino, B; Mandruzzato, S; Zambon, A; Rosolen, A; Carli, M; Ninfo, V; Zanovello, P

    2001-07-01

    MAGE, BAGE and GAGE genes encode tumor-associated antigens that are presented by HLA class I molecules and recognized by CD8(+) cytolytic T lymphocytes. These antigens are currently regarded as promising targets for active, specific tumor immunotherapy because MAGE, BAGE and GAGE genes are expressed in many human cancers of different histotype and are silent in normal tissues, with the exception of spermatogonia and placental cells. MAGE, BAGE and GAGE gene expression has been extensively studied in different tumors of adults but is largely unknown in many forms of pediatric solid cancer. Using RT-PCR, we analyzed MAGE-1, MAGE-2, MAGE-3, MAGE-4, MAGE-6, BAGE, GAGE-1,-2 or -8 and GAGE-3,-4,-5,-6 or -7b gene expression in 31 samples of pediatric rhabdomyosarcoma, the most frequent form of malignant soft tissue tumor in children. MAGE genes were expressed in a substantial proportion of patients (MAGE-1, 38%; MAGE-2, 51%; MAGE-3, 35%; MAGE-4, 22%; MAGE-6, 35%), while expression of BAGE (6%); GAGE-1, GAGE-2 and GAGE-8 (9%); and GAGE-3, GAGE-4, GAGE-5, GAGE-6 and GAGE-7B (16%) was less frequent. Overall, 58% of tumors expressed at least 1 gene, and 35% expressed 3 or more genes simultaneously. Our data suggest that a subset of rhabdomyosarcoma patients could be eligible for active, specific immunotherapy directed against MAGE, BAGE and GAGE antigens. Copyright 2001 Wiley-Liss, Inc.

  15. Levels at Streamflow Gaging Stations--A CD-ROM Based Training Class

    Science.gov (United States)

    Nolan, K. Michael; Jacobson, Nathan; Erickson, Robert; Landon, Stanley

    2003-01-01

    Streamgages record the elevation of the water surface above some reference surface, or datum. This datum is assumed to remain unchanged throughout the life of the gage. However, the elevation of gages and their supporting structures often change over time as a result of earthmovement, floods, ice, and debris. The surveying practice of leveling is used to establish datum for new gage structures and to check for vertical movement of those structures over time. Vertical changes in gage structures can affect stage-discharge relations and, thus, could result in incorrect discharge determinations. Datum checks are used to correct stage-discharge relations and allow the USGS to document gage datum throughout the life of a gage. This training presentation describes methods currently used by the U.S. Geological Survey to run levels at gaging stations. The presentation is narrated, but you control the pace of the presentation. If the computer you are using can view 'MPEG' videos you will be able to take advantage of videos found within the presentation. A test, found at the end of the presentation, can be taken to assess how well you understood the training material. The class is registered as class SW1307 with the National Training Center of the U.S. Geologcial Survey. The presentation was developed using Macromedia Director 8.5(1) and is contained in the file 'WRI-4002.exe', which should auto-launch after the CD-ROM is inserted in the PC. The program only runs on a windows-based personal computer (PC). A sound card and speakers are necessary to take advantage of the narration that accompanies the presentation. Text of narrations is provided, if you are unable to listen to the narrations. Instructions for installing and running the presentation are included in the file ' Intro.html'. The file 'Intro.html' is on the CD-ROM containing the presentation and is available from the presentation's help menu.

  16. "Fuel Gage" for Electric Vehicles

    Science.gov (United States)

    Rowlette, J. J.

    1984-01-01

    Gas-emmission and time-integrated-current measurements indicate battery charge state. Tests indicate possibility of monitoring state of charge of lead/acid batteries at any stage in charging cycle by measuring charging current and either gas evolution or electrode potential. Data then processed by microcomputer. Uses include cell voltage, cell pressure, cell temperature and rate of gas recombination on catalyst.

  17. MAGE-A1, GAGE and NY-ESO-1 cancer/testis antigen expression during human gonadal development

    DEFF Research Database (Denmark)

    Gjerstorff, Morten F; Kock, Kirsten; Nielsen, Ole

    2007-01-01

    BACKGROUND: Cancer/testis antigens (CTAs) are expressed in several cancers and during normal adult male germ cell differentiation. Little is known about their role in fetal development of human germ cells. METHODS: We examined expression of the CTAs MAGE-A1, GAGE and NY-ESO-1 in fetal gonads...... with highly proliferating germ cells, whereas GAGE proteins have a more general function in germ cells unrelated to any specific developmental stage. The recognition of differential cellular expression of GAGE, MAGE-A1, NY-ESO-1 and OCT4 may help define biologically distinct germ cell subpopulations....... cells and the staining intensity of all three CTAs peaked during the second trimester and gradually decreased towards birth in both male and female germ cells. In oocytes, MAGE-A1 expression terminated around birth, whereas NY-ESO-1 expression persisted through the neonatal stage and GAGE expression...

  18. Multi-stage fuel cell system method and apparatus

    Science.gov (United States)

    George, Thomas J.; Smith, William C.

    2000-01-01

    A high efficiency, multi-stage fuel cell system method and apparatus is provided. The fuel cell system is comprised of multiple fuel cell stages, whereby the temperatures of the fuel and oxidant gas streams and the percentage of fuel consumed in each stage are controlled to optimize fuel cell system efficiency. The stages are connected in a serial, flow-through arrangement such that the oxidant gas and fuel gas flowing through an upstream stage is conducted directly into the next adjacent downstream stage. The fuel cell stages are further arranged such that unspent fuel and oxidant laden gases too hot to continue within an upstream stage because of material constraints are conducted into a subsequent downstream stage which comprises a similar cell configuration, however, which is constructed from materials having a higher heat tolerance and designed to meet higher thermal demands. In addition, fuel is underutilized in each stage, resulting in a higher overall fuel cell system efficiency.

  19. 46 CFR 197.458 - Gages and timekeeping devices.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Gages and timekeeping devices. 197.458 Section 197.458 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE OCCUPATIONAL SAFETY AND HEALTH... § 197.458 Gages and timekeeping devices. The diving supervisor shall insure that— (a) Each depth gage...

  20. Development of Wireless Dimming Control System for LED Stage Light

    OpenAIRE

    Wang Hui Qin; Bai Shi Lei

    2016-01-01

    Compared with the existing wire dimming system of LED stage light which uses the heavy light operating console to adjust the brightness of stage light, a portable wireless dimming control system for LED stage lighting is proposed, fabricated and tested in this paper. The scheme with the core of ATmega16L microcontroller is composed of wireless transmission and reception units, constant current driving circuit of LED, and the control circuit between this two modules. Through the system present...

  1. Elevated-Temperature Tensile-Testing of Foil-Gage Metals

    Science.gov (United States)

    Blackburn, L. B.; Ellingsworth, J. R.

    1986-01-01

    Automated system for measuring strain in metal foils at temperatures above 500 degrees F (260 degrees C) uses mechanical extensometer and displacement transducer. System includes counterbalance feature, which eliminates weight contribution of extensometer and reduces grip pressure required for attachment to specimen. Counterbalancing feature overcomes two major difficulties in using extensometers with foil-gage specimens: (1) Weight of extensometer and transducer represents significant fraction of total load applied to specimen and may actually damage it; and (2) grip pressure required for attachment of extensometer to specimens may induce bending stresses in foil-gage materials.

  2. [Helicobacter pylori gastritis: assessment of OLGA and OLGIM staging systems].

    Science.gov (United States)

    Ben Slama, Sana; Ben Ghachem, Dorra; Dhaoui, Amen; Jomni, Mohamed Taieb; Dougui, Mohamed Hédi; Bellil, Khadija

    2016-01-01

    Helicobacter pylori (H pylori) gastritis presents a risk of cancer related to atrophy and intestinal metaplasia. Two recent classifications OLGA (Operative Link on Gastritis Assessment) and OLGIM (Operative Link on Gastritic Intestinal Metaplasia assessment) have been proposed to identify high-risk forms (stages III and IV). The aim of this study is to evaluate the OLGA and OLGIM staging systems in H pylori gastritis. A descriptive study of 100 cases of chronic H pylori gastritis was performed. The revaluation of Sydney System parameters of atrophy and intestinal metaplasia, of gastric antrum and corpus, allowed identifying respectively the stages of OLGA and OLGIM systems. The progressive risk of our H pylori gastritis was 6% according to OLGA staging and 7% according to OLGIM staging. Significant correlation was revealed between age and OLGA staging. High-risk gastritis according to OLGIM staging was significantly associated with moderate to severe atrophy. High-risk forms according to OLGA staging were associated in 80% of the cases to intestinal metaplasia. OLGA and OLGIM systems showed a highly significant positive correlation between them with a mismatch at 5% for H pylori gastritis. The OLGA and OLGIM staging systems in addition to Sydney System, allow selection of high risk forms of chronic gastritis requiring accurate observation.

  3. 46 CFR 197.318 - Gages and timekeeping devices.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Gages and timekeeping devices. 197.318 Section 197.318 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE OCCUPATIONAL SAFETY AND HEALTH STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.318 Gages and timekeeping devices...

  4. Neutron moisture gaging of agricultural soil

    International Nuclear Information System (INIS)

    Pospisil, S.; Janout, Z.; Kovacik, M.

    1987-01-01

    The design is described of a neutron moisture gage which consists of a measuring probe, neutron detector, small electronic recording device and a 241 Am-Be radionuclide source. The neutron detector consists of a surface barrier semiconductor silicon detector and a conversion layer of lithium fluoride. The detection of triton which is the reaction product of lithium with neutrons by the silicon detector is manifested as a voltage pulse. The detector has low sensitivity for fast neutrons and for gamma radiation and is suitable for determining moisture values in large volume samples. Verification and calibration measurements were carried out of chernozem, brown soil and podzolic soils in four series. The results are tabulated. Errors of measurement range between 0.8 to 1.0%. The precision of measurement could be improved by the calibration of the device for any type of soil. (E.S.). 4 tabs., 6 refs., 5 figs

  5. Design, analysis, and initial testing of a fiber-optic shear gage for three-dimensional, high-temperature flows

    Science.gov (United States)

    Orr, Matthew W.

    This investigation concerns the design, analysis, and initial testing of a new, two-component wall shear gage for 3D, high-temperature flows. This gage is a direct-measuring, non-nulling design with a round head surrounded by a small gap. Two flexure wheels are used to allow small motions of the floating head. Fiber-optic displacement sensors measure how far the polished faces of counterweights on the wheels move in relation to a fixed housing as the primary measurement system. No viscous damping was required. The gage has both fiber-optic instrumentation and strain gages mounted on the flexures for validation of the newer fiber optics. The sensor is constructed of Haynes RTM 230RTM, a high-temperature nickel alloy. The gage housing is made of 316 stainless steel. All components of the gage in pure fiber-optic form can survive to a temperature of 1073 K. The bonding methods of the backup strain gages limit their maximum temperature to 473 K. The dynamic range of the gage is from 0--500 Pa (0--10g) and higher shears can be measured by changing the floating head size. Extensive use of finite element modeling was critical to the design and analysis of the gage. Static structural, modal, and thermal analyses were performed on the flexures using the ANSYS finite element package. Static finite element analysis predicted the response of the flexures to a given load, and static calibrations using a direct force method confirmed these results. Finite element modal analysis results were within 16.4% for the first mode and within 30% for the second mode when compared with the experimentally determined modes. Vibration characteristics of the gage were determined from experimental free vibration data after the gage was subjected to an impulse. Uncertainties in the finished geometry make this level of error acceptable. A transient thermal analysis examined the effects of a very high heat flux on the exposed head of the gage. The 100,000 W/m2 heat flux used in this analysis is

  6. Design and Development of the MSL Descent Stage Propulsion System

    Science.gov (United States)

    Weiss, Jeffrey M.; Guernsey, Carl S.

    2013-01-01

    On August 5, 2012, The Mars Science Laboratory mission successfully landed the largest interplanetary rover ever built, Curiosity, on the surface of Mars. The Entry, Descent, and Landing (EDL) phase of this mission was by far the most complex landing ever attempted on a planetary body. The Descent Stage Propulsion System played an integral and critical role during Curiosity's EDL. The Descent Stage Propulsion System was a one of a kind hydrazine propulsion system designed specifically for the EDL phase of the MSL mission. It was designed, built, and tested at the Jet Propulsion Laboratory (JPL). The purpose of this paper is to present an overview of the design and development of the MSL Descent Stage Propulsion System. Driving requirements, system design, component selection, operational sequence of the system at Mars, new developments, and key challenges will be discussed.

  7. A proposed staging system and stage-specific interventions for familial adenomatous polyposis

    DEFF Research Database (Denmark)

    Lynch, Patrick M; Morris, Jeffrey S; Wen, Sijin

    2016-01-01

    BACKGROUND: It is not possible to accurately count adenomas in many patients with familial adenomatous polyposis (FAP). Nevertheless, polyp counts are critical in evaluating each patient's response to interventions. However, the U.S. Food and Drug Administration no longer recognizes the decrease...... classification scheme for lower GI tract polyposis. METHODS: Twenty-four colonoscopy or sigmoidoscopy videos were reviewed by 26 clinicians familiar with diagnosis and treatment of FAP. The reviewers independently assigned a stage to a case using the proposed system and chose a stage-specific intervention...... in the review of individual cases of polyposis. Therefore, reliable and clinically relevant means for measuring trial outcomes can be developed. Outlier cases showing wide scatter in stage assignment call for individualized attention and may be inappropriate for enrollment in clinical trials for this reason....

  8. Thermal expansion measurement of turbine and main steam piping by using strain gages in power plants

    International Nuclear Information System (INIS)

    Na, Sang Soo; Chung, Jae Won; Bong, Suk Kun; Jun, Dong Ki; Kim, Yun Suk

    2000-01-01

    One of the domestic co-generation plants have undergone excessive vibration problems of turbine attributed to external force for years. The root cause of turbine vibration may be shaft alignment problem which sometimes is changed by thermal expansion and external force, even if turbine technicians perfectly performed it. To evaluate the alignment condition from plant start-up to full load, a strain measurement of turbine and main steam piping subjected to thermal loading is monitored by using strain gages. The strain gages are bonded on both bearing housing adjusting bolts and pipe stoppers which installed in the x-direction of left-side main steam piping near the turbine inlet in order to monitor closely the effect of turbine under thermal deformation of turbine casing and main steam piping during plant full load. Also in situ load of constant support hangers in main steam piping system is measured by strain gages and its results are used to rebalance the hanger rod load. Consequently, the experimental stress analysis by using strain gages turns out to be very useful tool to diagnose the trouble and failures of not only to stationary components but to rotating machinery in power plants

  9. Disease severity staging system for idiopathic pulmonary fibrosis in Japan.

    Science.gov (United States)

    Kondoh, Yasuhiro; Taniguchi, Hiroyuki; Kataoka, Kensuke; Furukawa, Taiki; Ando, Masahiko; Murotani, Kenta; Mishima, Michiaki; Inoue, Yoshikazu; Ogura, Takashi; Bando, Masashi; Hagiwara, Koichi; Suda, Takafumi; Chiba, Hirofumi; Takahashi, Hiroki; Sugiyama, Yukihiko; Homma, Sakae

    2017-11-01

    In Japan, the classification of disease severity of idiopathic pulmonary fibrosis (IPF) (J-system) has been used in making decisions on medical care subsidies. The present J-system consists of arterial partial pressure of oxygen (PaO 2 ) and exercise desaturation in stages of I-IV. It provides a good prognostic classification in stages III and IV, but not in stages I and II. Therefore, we propose a revised system to improve discriminative ability in stages I and II. We compared the revised J-system with the present J-system using Cox proportional hazards model to predict mortality rate. We also evaluated the recently proposed GAP (Gender, Age and Physiology) system in comparison to both J-systems. Two-hundred and fifteen IPF patients were studied retrospectively. A univariate model showed that the present and revised J-systems and a modified GAP system were all significant prognostic factors. The C-statistic for discriminating prognosis was higher in the revised J-system than the modified GAP system and the present J-system (0.677, 0.652 and 0.659, respectively). The C-statistics of these models produced from the 10 000 bootstrap samples were similar to those of the original models, suggesting good internal validation (0.665 (95% CI: 0.621-0.705), 0.645 (0.600-0.686) and 0.659 (0.616-0.700), respectively). Multivariate analysis revealed that the revised J-system (P = 0.0038) and the modified GAP system (P = 0.0029) were independent prognostic factors. The revised J-system can provide a better mortality prediction than the present one. Both the revised J-system and the modified GAP system are independent and valuable tools for prognostication and clinical management for IPF. © 2017 Asian Pacific Society of Respirology.

  10. Parachute systems for the atmospheric reentry of launcher upper stages

    Directory of Open Access Journals (Sweden)

    Bogdan DOBRESCU

    2017-03-01

    Full Text Available Parachute systems can be used to control the reentry trajectory of launcher upper stages, in order to lower the risks to the population or facilitate the retrieval of the stage. Several types of parachutes deployed at subsonic, supersonic and hypersonic speeds are analyzed, modeled as single and multistage systems. The performance of deceleration parachutes depends on their drag area and deployment conditions, while gliding parachutes are configured to achieve stable flight with a high glide ratio. Gliding parachutes can be autonomously guided to a low risk landing area. Sizing the canopy is shown to be an effective method to reduce parachute sensitivity to wind. The reentry trajectory of a launcher upper stage is simulated for each parachute system configuration and the results are compared to the nominal reentry case.

  11. Suitability of Strain Gage Sensors for Integration into Smart Sport Equipment: A Golf Club Example.

    Science.gov (United States)

    Umek, Anton; Zhang, Yuan; Tomažič, Sašo; Kos, Anton

    2017-04-21

    Wearable devices and smart sport equipment are being increasingly used in amateur and professional sports. Smart sport equipment employs various sensors for detecting its state and actions. The correct choice of the most appropriate sensor(s) is of paramount importance for efficient and successful operation of sport equipment. When integrated into the sport equipment, ideal sensors are unobstructive, and do not change the functionality of the equipment. The article focuses on experiments for identification and selection of sensors that are suitable for the integration into a golf club with the final goal of their use in real time biofeedback applications. We tested two orthogonally affixed strain gage (SG) sensors, a 3-axis accelerometer, and a 3-axis gyroscope. The strain gage sensors are calibrated and validated in the laboratory environment by a highly accurate Qualisys Track Manager (QTM) optical tracking system. Field test results show that different types of golf swing and improper movement in early phases of golf swing can be detected with strain gage sensors attached to the shaft of the golf club. Thus they are suitable for biofeedback applications to help golfers to learn repetitive golf swings. It is suggested that the use of strain gage sensors can improve the golf swing technical error detection accuracy and that strain gage sensors alone are enough for basic golf swing analysis. Our final goal is to be able to acquire and analyze as many parameters of a smart golf club in real time during the entire duration of the swing. This would give us the ability to design mobile and cloud biofeedback applications with terminal or concurrent feedback that will enable us to speed-up motor skill learning in golf.

  12. F-4 Service Life Tracking Program (Crack Growth Gages)

    Science.gov (United States)

    1979-12-01

    Analysis and Test Results for Gage Calibration Tests - BL 100 Spectrum -Test 2 83 0.415 C .. .. ... Gage 38I , -T-f Z 0235 ...... y C: 0 2..6810121 0.407V...Limit Sess Figue 91. reicted arnd easu rFawk Seha o Gaealdaio Sp.ecimens 0.87 Figure~ 90.iSresanest orcinFco sd o nlsso onrFa Hl PrdceaFa hp Couterrn

  13. Central nervous system relapse of treated stage IV neuroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Palasis, S.; Egelhoff, J.C.; Koch, B.L.; Ball, W.S. Jr. [Department of Radiology, Children`s Hospital Medical Center, Cincinnati, OH (United States); Morris, J.D. [Department of Pediatrics, Children`s Hospital Medical Center, Cincinnati, OH (United States)

    1998-12-01

    Neuroblastoma is the most common extracranial solid tumor in pediatrics. The long-term survival of patients with advanced-stage neurobastoma has remarkably improved secondary to aggressive treatment protocols including autologous bone marrow transplant (BMT). As a result, a different natural history of this disease is being reported with unusual, late manifestations. The central nervous system (CNS), once a rare site of disease, is being involved with increasing frequency. Appropriate neuroimaging in these patients is important. Two cases of patients with treated stage IV neuroblastoma who developed isolated CNS metastases are presented. The proposed pathogenesis and neuroradiologic manifestations of this complication are reviewed. (orig.) With 2 figs., 23 refs.

  14. Multi stage unreliable retrial Queueing system with Bernoulli vacation

    Science.gov (United States)

    Radha, J.; Indhira, K.; Chandrasekaran, V. M.

    2017-11-01

    In this work we considered the Bernoulli vacation in group arrival retrial queues with unreliable server. Here, a server providing service in k stages. Any arriving group of units finds the server free, one from the group entering the first stage of service and the rest are joining into the orbit. After completion of the i th, (i=1,2,…k) stage of service, the customer may go to (i+1)th stage with probability θi , or leave the system with probability qi = 1 – θi , (i = 1,2,…k – 1) and qi = 1, (i = k). The server may enjoy vacation (orbit is empty or not) with probability v after finishing the service or continuing the service with probability 1-v. After finishing the vacation, the server search for the customer in the orbit with probability θ or remains idle for new arrival with probability 1-θ. We analyzed the system using the method of supplementary variable.

  15. An overview of the use of capacitive strain gages in the United States

    International Nuclear Information System (INIS)

    Roland, D.M.

    1978-01-01

    The intention of this paper is to present an overview of the development and a review of selected applications of the capacitive strain-gage in the United-Staates from 1973 to present. The paper includes a brief history and description of the system currently in use on laboratory tests such as shear lag testing done at Boeing, thermal ratchetting done at Oak Ridge National Laboratories, and field tests done on a catalysator cracker and an operating power plant. (orig.) [de

  16. Comparison of Heat Flux Gages for High Enthalpy Flows - NASA Ames and IRS

    Science.gov (United States)

    Loehle, Stefan; Nawaz, Anuscheh; Herdrich, Georg; Fasoulas, Stefanos; Martinez, Edward; Raiche, George

    2016-01-01

    This article is a companion to a paper on heat flux measurements as initiated under a Space Act Agreement in 2011. The current focus of this collaboration between the Institute of Space Systems (IRS) of the University of Stuttgart and NASA Ames Research Center is the comparison and refinement of diagnostic measurements. A first experimental campaign to test different heat flux gages in the NASA Interaction Heating Facility (IHF) and the Plasmawindkanaele (PWK) at IRS was established. This paper focuses on the results of the measurements conducted at IRS. The tested gages included a at face and hemispherical probe head, a 4" hemispherical slug calorimeter, a null-point calorimeter from Ames and a null-point calorimeter developed for this purpose at IRS. The Ames null-point calorimeter was unfortunately defective upon arrival. The measured heat fluxes agree fairly well with each other. The reason for discrepancies can be attributed to signal-to-noise levels and the probe geometry.

  17. A Thermoelectric Generation System and Its Power Electronics Stage

    Science.gov (United States)

    Gao, Junling; Sun, Kai; Ni, Longxian; Chen, Min; Kang, Zhengdong; Zhang, Li; Xing, Yan; Zhang, Jianzhong

    2012-06-01

    The electricity produced by a thermoelectric generator (TEG) must satisfy the requirements of specific loads given the signal level, stability, and power performance. In the design of such systems, one major challenge involves the interactions between the thermoelectric power source and the power stage and signal-conditioning circuits of the load, including DC-DC conversion, the maximum power point tracking (MPPT) controller, and other power management controllers. In this paper, a survey of existing power electronics designs for TEG systems is presented first. Second, a flat, wall-like TEG system consisting of 32 modules is experimentally optimized, and the improved power parameters are tested. Power-conditioning circuitry based on an interleaved boost DC-DC converter is then developed for the TEG system in terms of the tested power specification. The power electronics design features a combined control scheme with an MPPT and a constant output voltage as well as the low-voltage and high-current output characteristics of the TEG system. The experimental results of the TEG system with the power electronics stage and with purely resistive loads are compared. The comparisons verify the feasibility and effectiveness of the proposed design. Finally, the thermal-electric coupling effects caused by current-related heat source terms, such as the Peltier effect etc., are reported and discussed, and the potential influence on the power electronics design due to such coupling is analyzed.

  18. Multimodal Therapy for Stage III Retinoblastoma (International Retinoblastoma Staging System): A Prospective Comparative Study.

    Science.gov (United States)

    Chawla, Bhavna; Hasan, Fahmi; Seth, Rachna; Pathy, Sushmita; Pattebahadur, Rajesh; Sharma, Sanjay; Upadhyaya, Ashish; Azad, Rajvardhan

    2016-09-01

    To compare the efficacy of 2 chemotherapeutic drug combinations as part of multimodal therapy for orbital retinoblastoma. Prospective, comparative, study. Patients with stage III retinoblastoma (International Retinoblastoma Staging System). Demographic and clinical features were recorded at presentation. Treatment consisted of a multimodal protocol with neoadjuvant chemotherapy, enucleation, orbital external-beam radiotherapy, and adjuvant chemotherapy. For chemotherapy, patients were randomized into 2 groups: group A patients were treated with vincristine, etoposide, and carboplatin (VEC) and group B patients were treated with carboplatin and etoposide, alternating with cyclophosphamide, idarubicin, and vincristine. Treatment outcomes and adverse effects were recorded. Efficacy parameters were compared between the groups. Survival probability, cause of death, and chemotherapy-related toxicity. A total of 54 children were recruited (27 in each group). The mean ± SD follow-up was 21.3±11.34 months. The overall Kaplan-Meier survival probability was 80% (95% confidence interval [CI], 0.67-0.89) and 42% (95% CI, 0.24-0.59) at 1 year and 4 years, respectively. There were 9 deaths in group A and 15 deaths in group B. The Kaplan-Meier survival probability at 1 year was similar between the groups: 81% (95% CI, 0.60-0.91) and 79% (95% CI, 0.58-0.9) for groups A and B, respectively. At 4 years, the survival probability for group A was higher (63% [95% CI, 0.41-0.79] vs. 25% [95% CI, 0.08-0.46] for groups A and B, respectively), with a strong trend of better survival in group A over time (P = 0.05). The major cause of death was central nervous system relapse (8 patients in group A and 7 patients in group B). Two patients in group B died of sepsis after febrile neutropenia. Grade 3 and grade 4 hematologic toxicities were more common in group B, with a significant difference in grade 4 neutropenia (P = 0.002). This study compared the outcomes of VEC chemotherapy with a 5

  19. Changes of endocrine and ultrasound markers as ovarian aging in modifying the Stages of Reproductive Aging Workshop (STRAW) staging system with subclassification of mid reproductive age stage.

    Science.gov (United States)

    Ding, Ting; Luo, Aiyue; Jiang, Jingjing; Du, Xiaofang; Yang, Shuhong; Lai, Zhiwen; Shen, Wei; Lu, Yunping; Ma, Ding; Wang, Shixuan

    2013-01-01

    To demonstrate the changes of ovarian aging markers across the Stages of Reproductive Aging Workshop (STRAW) stages and modify it with subclassification of mid reproductive age stage (MR). Healthy females were classified according to the STRAW system. Serum basal FSH, LH, E2, and anti-Müllerian hormone (AMH) were detected, FSH/LH ratio calculated, and antral follicle counts (AFCs) determined in follicular phase. Progression through the whole STRAW stages under MR stage subdivided is associated with elevations in FSH, LH, FSH/LH ratio and decreases in E2, AMH and AFCs (p age in MR stage. 0.982 ng/ml AMH and 3 antral follicles (low level of MR 25-30 years) were set as cutoffs to distinguish MR stage into early mid reproductive age (EMR) and late mid reproductive age (LMR) stages. The women in EMR stage compared with LMR could retrieve more oocytes in IVF treatment (p stage, demonstrating disparate reproductive aging period with reduced ovarian reserve in young age across the STRAW stages.

  20. Streamflow gaging in a remote area using cellular telephone telemetry

    International Nuclear Information System (INIS)

    Wheelock, D.C.; Hurless, R.C.

    1991-01-01

    In this paper a case study is presented describing the utilization of cellular phone technology in a remote sensing situation. Because expected annual energy estimates are vital in planning small hydroelectric projects, it is important that the flow data from river gaging stations provide reliable information to the engineer. When the project is situated in a remote area where gaging stations are unavailable. such as on an island or in emerging nations, the design engineer may need to provide the flow data himself. The problem of transmitting the flow data from a remote mountain stream away from any roads and telephone lines, to the office for computer analysis was solved by using an innovative method utilizing cellular telephones to access raw data from solar powered data loggers and pressure transducer gaging instruments

  1. Standard guide for installing bonded resistance strain gages

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    1993-01-01

    1.1 This guide provides guidelines for installing bonded resistance strain gages. It is not intended to be used for bulk or diffused semiconductor gages. This document pertains only to adhesively bonded strain gages. 1.2 The values stated in inch-pound units are to be regarded as standard. The values given in parentheses are mathematical conversions to SI units that are provided for information only and are not considered standard. 1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

  2. Method and system for dual resolution translation stage

    Science.gov (United States)

    Halpin, John Michael

    2014-04-22

    A dual resolution translation stage includes a stage assembly operable to receive an optical element and a low resolution adjustment device mechanically coupled to the stage assembly. The dual resolution stage also includes an adjustable pivot block mechanically coupled to the stage assembly. The adjustable pivot block includes a pivot shaft. The dual resolution stage further includes a lever arm mechanically coupled to the adjustable pivot block. The lever arm is operable to pivot about the pivot shaft. The dual resolution stage additionally includes a high resolution adjustment device mechanically coupled to the lever arm and the stage assembly.

  3. Development of RLV-TD Stage Separation System

    Science.gov (United States)

    Mohan, Ganesh; Rao, Y. Naga Sreenivasa; Prakash, P.; Subramanian, U. A.; Purushothaman, P.; Premdas, M.; Abraham, Baby; Kishorenath, V.; Jayachandran, T.

    2017-12-01

    Hyper Sonic Experiment (HEX-01), with main focus on the aero thermodynamic characterization and end to end autonomous mission management, is the first in a series of demonstrators planned by ISRO for the development of a Reusable Launch Vehicle (RLV). This paper gives the evolution of the split collet based separation system used in the separation of the spent booster stage from the RLV-Technology Demonstrator Vehicle (TDV). The separation mechanism is very compact, yet has a very high load bearing capacity. The design details and the challenges faced during flight qualification of the system are discussed in this paper. There are a lot of promising areas where this system can be used.

  4. Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carcinoma.

    Science.gov (United States)

    Kobayashi, Y; Higashi, T; Nouso, K; Nakatsukasa, H; Ishizaki, M; Kaneyoshi, T; Toshikuni, N; Kariyama, K; Nakayama, E; Tsuji, T

    2000-04-01

    The MAGE, GAGE and BAGE genes encode tumor antigens recognized by autologous cytotoxic T lymphocytes. The aim of this study was to evaluate the possibility of using these genes as molecular markers and as the targets of specific immunotherapy for human hepatocellular carcinoma (HCC). The expressions of MAGE-1, MAGE-3, GAGE1-6, GAGE1-2 and BAGE mRNA in 33 surgically resected HCC samples and 26 of their corresponding non-cancerous samples (11 liver cirrhosis and 15 chronic hepatitis) were studied by a reverse-transcription polymerase chain reaction, and were compared with clinicopathological parameters. The expression of MAGE-1 was also examined in 16 biopsied HCC samples. MAGE-1, MAGE-3, GAGE1-6, GAGE1-2 and BAGE mRNA were expressed in 67%, 39%, 36%, 30%, and 21% of the HCC, respectively. At least one transcript was detected in 88% of the HCC, while no expression was observed in the non-cancerous livers. There was no significant correlation between the expression of any of the tumor antigens examined and the differentiation stage or size of the HCC. Especially, MAGE-1 was highly expressed in small HCC with a diameter of less than 2 cm and in well-differentiated HCC (81% and 70%, respectively), and was also expressed even in alpha-fetoprotein-negative and PIVKA-II-negative HCC (58% and 76%, respectively). The MAGE-1 expression was detected in 69% of biopsied HCC samples and the expression was high in both small and well-differentiated HCC. These tumor-specific antigens can be useful as molecular markers and as the possible target molecules for the specific immunotherapy of human HCC.

  5. MAGE, BAGE, and GAGE gene expression in patients with esophageal squamous cell carcinoma and adenocarcinoma of the gastric cardia.

    Science.gov (United States)

    Zambon, A; Mandruzzato, S; Parenti, A; Macino, B; Dalerba, P; Ruol, A; Merigliano, S; Zaninotto, G; Zanovello, P

    2001-05-15

    The MAGE, BAGE, and GAGE gene families code for distinct, tumor specific antigens that are recognized by cytotoxic T lymphocytes in the context of HLA molecules. The purpose of this study was to analyze MAGE, BAGE, and GAGE gene expression in the two major histologic types of esophageal carcinoma, squamous carcinoma (ESCc) and adenocarcinoma (CAc), and to correlate their expression patterns with the principal prognostic parameters and long term survival. Gene expression was analyzed in surgical samples from 24 patients with ESCc and 24 patients with CAc by reverse transcriptase-polymerase chain reaction amplification (RT-PCR). None of the patients had received preoperative chemotherapy or radiotherapy, and all were followed until death or for a minimum of 4 years. Sixteen ESCc samples (67%) and 9 CAc samples (37.5%) expressed at least one of the genes under study. The expression of each MAGE gene in the two histologic types was not significantly different, with the exception of MAGE-4, which was expressed more in ESCc samples than in CAc samples. BAGE and GAGE expression was rather low and, in every case, was associated with the expression of at least one MAGE gene. In the group as a whole, and in both ESCc and CAc subgroups, no significant correlation emerged between the expression of any gene and prognostic parameters, such as pathologic tumor, lymph node, or disease stage. Nevertheless, BAGE or GAGE expression was related significantly to a poor prognosis, whereas the expression of MAGE genes (in the absence of BAGE and GAGE expression) was related significantly to a good prognosis. Copyright 2001 American Cancer Society.

  6. Evaluation of the stage IB designation of the American Joint Committee on Cancer staging system in breast cancer.

    Science.gov (United States)

    Mittendorf, Elizabeth A; Ballman, Karla V; McCall, Linda M; Yi, Min; Sahin, Aysegul A; Bedrosian, Isabelle; Hansen, Nora; Gabram, Sheryl; Hurd, Thelma; Giuliano, Armando E; Hunt, Kelly K

    2015-04-01

    The seventh edition of the American Joint Committee on Cancer (AJCC) staging system for breast cancer differentiates patients with T1 tumors and lymph node micrometastases (stage IB) from patients with T1 tumors and negative nodes (stage IA). This study was undertaken to determine the utility of the stage IB designation. The following two cohorts of patients with breast cancer were identified: 3,474 patients treated at The University of Texas MD Anderson Cancer Center from 1993 to 2007 and 4,590 patients from the American College of Surgeons Oncology Group (ACOSOG) Z0010 trial. Clinicopathologic and outcomes data were recorded, and disease was staged according to the seventh edition AJCC staging system. Recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) were determined using the Kaplan-Meier method and compared using the log-rank test. Median follow-up times were 6.1 years and 9.0 years for the MD Anderson Cancer Center and ACOSOG cohorts, respectively. In both cohorts, there were no significant differences between patients with stage IA and stage IB disease in 5- or 10-year RFS, DSS, or OS. Estrogen receptor (ER) status and grade significantly stratified patients with stage I disease with respect to RFS, DSS, and OS. Among patients with T1 breast cancer, individuals with micrometastases and those with negative nodes have similar survival outcomes. ER status and grade are better discriminants of survival than the presence of small-volume nodal metastases. In preparing the next edition of the AJCC staging system, consideration should be given to eliminating the stage IB designation and incorporating biologic factors. © 2014 by American Society of Clinical Oncology.

  7. Testing for moisture content in foods by neutron gaging

    International Nuclear Information System (INIS)

    Helf, S.

    1976-01-01

    Neutron gaging was applied to the testing for moisture content in bulk powdered foods and in canned Army field rations. The technique is based on the moderation or thermalization of fast neutrons by hydrogenous matter and the measurement of thermal neutron intensity as a function of moisture content. A small californium-252 capsule, of approximate output 10 7 neutrons per second, was used as the source of fast neutrons. It is concluded that a fast neutron moderation technique is feasible for the nondestructive measurement or control of moisture or both in near-dry bulk powdered foods. Samples must be measured under identical geometric conditions, that is, uniform bulk density and volume using a standard metal container or cell. For canned or otherwise prepacked rations, measurement of moisture is interfered with by variations in fill weight among cans or packages of the same product. A gamma-ray attenuation gaging method proved to be of insufficient sensitivity to correct for fill weight variation and was further complicated by nonuniformity in can wall dimensions. Neutron gaging, however, appears to be quite useful for monitoring a standard packaged item for fill weight since the neutron signal is virtually unaffected by variations in container dimensions. The radiation dose imparted to a sample or package of food subjected to such a test is judged to pose no threat to humans from subsequent consumption of the food. An estimate is given for the cost range of a commercial neutron gage and of encapsulated radioisotopic neutron sources

  8. Space Launch System, Core Stage, Structural Test Design and Implementation

    Science.gov (United States)

    Shaughnessy, Ray

    2017-01-01

    As part of the National Aeronautics and Space Administration's (NASA) Space Launch System (SLS) Program, engineers at NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama are working to design, develop and implement the SLS Core Stage structural testing. The SLS will have the capability to return humans to the Moon and beyond and its first launch is scheduled for December of 2017. The SLS Core Stage consist of five major elements; Forward Skirt, Liquid Oxygen (LOX) tank, Intertank (IT), Liquid Hydrogen (LH2) tank and the Engine Section (ES). Structural Test Articles (STA) for each of these elements are being designed and produced by Boeing at Michoud Assembly Facility located in New Orleans, La. The structural test for the Core Stage STAs (LH2, LOX, IT and ES) are to be conducted by the MSFC Test Laboratory. Additionally, the MSFC Test Laboratory manages the Structural Test Equipment (STE) design and development to support the STAs. It was decided early (April 2012) in the project life that the LH2 and LOX tank STAs would require new test stands and the Engine Section and Intertank would be tested in existing facilities. This decision impacted schedules immediately because the new facilities would require Construction of Facilities (C of F) funds that require congressional approval and long lead times. The Engine Section and Intertank structural test are to be conducted in existing facilities which will limit lead times required to support the first launch of SLS. With a SLS launch date of December, 2017 Boeing had a need date for testing to be complete by September of 2017 to support flight certification requirements. The test facilities were required to be ready by October of 2016 to support test article delivery. The race was on to get the stands ready before Test Article delivery and meet the test complete date of September 2017. This paper documents the past and current design and development phases and the supporting processes, tools, and

  9. Oceanographic data collected from Hammond Tide Gage by Center for Coastal Margin Observation and Prediction (CMOP) and assembled by Northwest Association of Networked Ocean Observation Systems (NANOOS) in the Columbia River Estuary and North East Pacific Ocean from 2005-06-24 to 2013-02-08 (NCEI Accession 0162194)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0162194 contains navigational and physical data collected at Hammond Tide Gage, a fixed station in the Columbia River estuary - Washington/Oregon....

  10. Assessment of the prognostic value of the 8th AJCC staging system for patients with clinically staged prostate cancer; A time to sub-classify stage IV?

    Directory of Open Access Journals (Sweden)

    Omar Abdel-Rahman

    Full Text Available The American Joint Committee on Cancer (AJCC staging system (8th edition for prostate cancer has been published. The current study seeks to validate the prognostic performance of the changes in the new system among clinically staged prostate cancer patients registered within the surveillance, epidemiology and end results (SEER database.SEER database (2004-2014 has been accessed through SEER*Stat program and AJCC 7th and 8th edition stages were calculated utilizing T, N and M stages as well as baseline prostatic specific antigen (PSA and grade group. Cancer-specific and overall survival analyses according to 6th, 7th and 8th editions were conducted through Kaplan-Meier analysis. Moreover, multivariate analysis was conducted through a Cox proportional hazard model.A total of 110499 patients with prostate cancer were identified in the period from 2004-2014.For cancer- specific survival according to 8th AJCC, all pair wise P values for comparison were significant (<0.01 except for stage IIA vs. IIB; while for overall survival according to 8th AJCC, all pair wise P values for comparison were significant (<0.02 except for stage IIIA vs. IIIB. Results of c-index assessment for cancer-specific survival for the three AJCC editions were as follows: c-index for AJCC 6th edition was 0.816; c-index for AJCC 7th edition was 0.897; c-index for AJCC 8th edition was 0.907. For stage IVB prostate cancer (i.e.M1 disease, further sub-staging was proposed according to M1 sub-stage (i.e. M1a, M1b and M1c. Pair wise comparison between these proposed sub-stages was conducted for both cancer-specific and overall survival. For both cancer-specific and overall survival, all pair wise P values for comparisons were <0.0001.Compared to older staging systems (6th and 7th, the 8th system is more discriminatory. Further sub-classification of stage IV disease is suggested.

  11. How does magnetic resonance imaging influence staging according to AJCC staging system for nasopharyngeal carcinoma compared with computed tomography?

    Science.gov (United States)

    Liao, Xin-Biao; Mao, Yan-Ping; Liu, Li-Zhi; Tang, Ling-Long; Sun, Ying; Wang, Yan; Lin, Ai-Hua; Cui, Chun-Yan; Li, Li; Ma, Jun

    2008-12-01

    To analyze the degree and pattern of influence of magnetic resonance imaging (MRI) on staging according to the 6th edition of the American Joint Committee on Cancer staging system compared with computed tomography (CT). The MRI and CT scans and medical records of 420 consecutive patients with newly diagnosed nasopharyngeal carcinoma (NPC) were analyzed retrospectively. The tumors of all patients were staged according to the 6th edition of the American Joint Committee on Cancer staging system. A significant difference (p <0.05) was found between CT and MRI in demonstrating involvement in the oropharynx (CT, 25.0% vs. MRI, 14.5%), prevertebral muscle (CT, 18.4% vs. MRI, 36.0%), parapharyngeal space (CT, 82.6% vs. MRI, 68.8%), skull base (CT, 31.0% vs. MRI, 52.6%), sphenoid sinus (CT, 13.6% vs. MRI, 16.7%), ethmoid sinus (CT, 7.1% vs. MRI, 3.3%), intracranial area (CT, 4.8% vs. MRI, 16.0%), and retropharyngeal lymph nodes (CT, 52.1% vs. MRI, 69.0%). The incidence of cervical lymph node metastasis and lymph node metastasis at each level was similar according to CT and MRI. MRI resulted in changes in 49.8% of T stage cases, 10.7% of N stage cases, and 38.6% of clinical stage cases. MRI demonstrated early primary tumor involvement more precisely and deep primary tumor infiltration more easily. The use of MRI caused dramatic changes in the results of the T stage and clinical staging and should be preferred to CT in staging NPC. Patients would benefit from changes in treatment strategies resulting from the use of MRI.

  12. Proposal for a new staging system for osteoradionecrosis of the mandible

    NARCIS (Netherlands)

    Karagozoglu, K.H.; Dekker, H.; Rietveld, D.H.F.; de Bree, R.; Schulten, E.A.J.M.; Kantola, S.; Forouzanfar, T.; van der Waal, I.

    2014-01-01

    The presented staging system seems well reproducible, facilitating the comparison of study groups dealing with the various issues of osteoradionecrosis of the mandible. It is yet to be evaluated whether the presently proposed staging system is useful for management purposes.

  13. Alternatives generation and analysis for phase I intermediate waste feed staging system design requirements

    Energy Technology Data Exchange (ETDEWEB)

    Britton, M.D.

    1996-10-02

    This document provides; a decision analysis summary; problem statement; constraints, requirements, and assumptions; decision criteria; intermediate waste feed staging system options and alternatives generation and screening; intermediate waste feed staging system design concepts; intermediate waste feed staging system alternative evaluation and analysis; and open issues and actions.

  14. Certain peculiarities in metrological provision of radioisotope thickness gages with microprocessors

    International Nuclear Information System (INIS)

    Sobolevskij, A.E.; Tesnavs, Eh.R.

    1985-01-01

    Possibility for radioisotope thickness gage self-testing by means of microprocessors is considered. Microprocessors are to function as follows: to indicate time period, being equal to intertesting interval; to bring out a thickness gage to testing conditions, when the intertesting period lapsing; the provide control of automatic devices, implementing a test; to carry out experimental data processing for estimation of thickness gage parameters; to compare parameter estimates with standards; to solve the problem of thickness gage serviceability; to bring out or blokade the thickness gage measuring conditions; to type data on testing results and the test sertificate

  15. Skin-friction measurements with hot-wire gages

    Science.gov (United States)

    Houdeville, R.; Juillen, J. C.; Cousteix, J.

    1983-11-01

    The development of two hot-wire gauges for implantation in wind-tunnel models and their application to the measurement of skin-friction phenomena are reported. The measurement principle is explained; the design and calibration of a single-wire gage containing a thermocouple for temperature determination (Cousteix and Juillen, 1982-1983) are summarized; and sample results for 2D and 3D flows with positive pressure gradients are shown. An advanced design employing a thin hot film deposited on an 80-micron-diameter quartz fiber extending into a 1-mm-sq 0.8-mm-deep cavity is characterized and demonstrated on a pulsed flow on a flat plate, Tollmien-Schlichting waves, and a turbulent boundary layer. Two cold-wire temperature sensors are added to this gage to permit detection of the skin of the skin friction in the separated flow over a cylinder.

  16. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines

    International Nuclear Information System (INIS)

    Zhang, Shiqian; Zhou, Xiaoliang; Yu, Hao; Yu, Yunhai

    2010-01-01

    To observe mRNA expression of tumor-specific antigen MAGE, BAGE and GAGE in epithelial ovarian cancer tissues and cell lines, to explore the relationship between gene expression and diagnosis, treatment and prognosis of ovarian cancer, and to evaluate the feasibility of their gene products as markers, and an immunotherapy target for ovarian cancer. mRNA expression of MAGE-1, MAGE-3, GAGE-1/2 and BAGE were determined by reverse transcription polymerase chain reaction (RT-PCR) in 14 cases of normal ovarian tissue, 20 cases of ovarian benign tumor specimens, 41 cases of ovarian cancer specimens, and ovarian cancer cell lines SKOV3, A2780, and COC1. MAGE, GAGE and BAGE genes were not expressed in normal ovarian tissue. In benign tumors, only the MAGE gene was expressed; the expression rate of this gene in benign tumors was 15% (3/20). In ovarian cancer tissues, MAGE-1 and MAGE-3 was highly expressed, with expression rates of 53.7% (22/41) and 36.6% (15/41), while GAGE-1/2 and BAGE had relatively low expression, with rates of 26.8% (11/41) and 14.6% (6/41). In metastatic lesions of ovarian cancer, only MAGE-1 and BAGE were expressed, with expression rates of 28.6% (2/7) and 14.3% (1/7). The positive expression rates of MAGE-1 and MAGE-3 in serous cystadenocarcinoma were significantly higher than that in other types of ovarian cancer (P < 0.05). Gene expression rate was not correlated with menopause or lymph node metastasis. Positive expression of MAGE-1 and MAGE-3 was positively correlated with tumor differentiation and the clinical stage of the ovarian cancer. In addition, the positive expression rate of BAGE was significantly higher in ovarian cancer patients with ascites (P < 0.05). The mRNA expression profiles of MAGE, GAGE and BAGE in ovarian carcinoma cell lines SKOV3, A2780 and COC1 varied, but there was at least one gene expressed in each cell line. Tumor-specific antigen MAGE, BAGE and GAGE may play a role in the occurrence and development of ovarian cancer

  17. Standard Practice for Ionization Gage Application to Space Simulators

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    1970-01-01

    1.1 This practice provides application criteria, definitions, and supplemental information to assist the user in obtaining meaningful vacuum ionization gage measurements below 10−1 N/m2 (10−3 torr) in space-simulation facilities. Since a variety of influences can alter observed vacuum measurements, means of identifying and assessing potential problem areas receive considerable attention. This practice must be considered informational, for it is impossible to specify a means of applying the vacuum-measuring equipment to guarantee accuracy of the observed vacuum measurement. Therefore, the user's judgment is essential so that if a problem area is identified, suitable steps can be taken to either minimize the effect, correct the observed readings as appropriate, or note the possible error in the observation. 1.2 While much of the discussion is concerned with the application of hot-cathode ionization gages, no exclusion is made of cold-cathode designs. Since a great deal more experience with hot-cathode gage...

  18. Combined fuel and air staged power generation system

    Science.gov (United States)

    Rabovitser, Iosif K; Pratapas, John M; Boulanov, Dmitri

    2014-05-27

    A method and apparatus for generation of electric power employing fuel and air staging in which a first stage gas turbine and a second stage partial oxidation gas turbine power operated in parallel. A first portion of fuel and oxidant are provided to the first stage gas turbine which generates a first portion of electric power and a hot oxidant. A second portion of fuel and oxidant are provided to the second stage partial oxidation gas turbine which generates a second portion of electric power and a hot syngas. The hot oxidant and the hot syngas are provided to a bottoming cycle employing a fuel-fired boiler by which a third portion of electric power is generated.

  19. METAHEURISTICS FOR OPTIMIZING SAFETY STOCK IN MULTI STAGE INVENTORY SYSTEM

    Directory of Open Access Journals (Sweden)

    Gordan Badurina

    2013-02-01

    Full Text Available Managing the right level of inventory is critical in order to achieve the targeted level of customer service, but it also carries significant cost in supply chain. In majority of cases companies define safety stock on the most downstream level, i.e. the finished product level, using different analytical methods. Safety stock on upstream level, however, usually covers only those problems which companies face on that particular level (uncertainty of delivery, issues in production, etc.. This paper looks into optimizing safety stock in a pharmaceutical supply considering the three stages inventory system. The problem is defined as a single criterion mixed integer programming problem. The objective is to minimize the inventory cost while the service level is predetermined. In order to coordinate inventories at all echelons, the variable representing the so-called service time is introduced. Because of the problem dimensions, metaheuristics based on genetic algorithm and simulated annealing are constructed and compared, using real data from a Croatian pharmaceutical company. The computational results are presented evidencing improvements in minimizing inventory costs.

  20. 75 FR 12674 - Amendment of Jet Routes and VOR Federal Airways in the Vicinity of Gage, OK

    Science.gov (United States)

    2010-03-17

    ... Airways in the Vicinity of Gage, OK AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule... (VOR) Federal Airways in the vicinity of Gage, OK. The FAA is taking this action because the Gage VHF... Airways V-12, V-17, V-190, V-280, V-390, V-402, and V- 507 in the vicinity of Gage, OK. Currently, these...

  1. Experimental investigation of two-stage thermoelectric generator system integrated with phase change materials

    DEFF Research Database (Denmark)

    Ahmadi Atouei, Saeed; Ranjbar, Ali Akbar; Rezaniakolaei, Alireza

    2017-01-01

    experimentally. In the first stage, a TEG module installed between a phase change material (PCM) heat sink, as cooling system, and an electrical heater, as the heat source. Because of the inherent characteristics of PCMs to save the thermal energy as latent heat, the PCM heat sink is used as the heat source...... of the second stage TEGs. In the second stage, five smaller TEG modules are installed around the PCM with individual heat sinks for cooling with natural convection. In order to have a comparison between a common TEG system and the proposed two-stage TEG system, a one-stage thermoelectric generator with forced...

  2. Ten years of real-time streamflow gaging of turkey creek - where we have been and where we are going

    Science.gov (United States)

    Paul Conrads; Devendra Amatya

    2016-01-01

    The Turkey Creek watershed is a third-order coastal plain stream system draining an area of approximately 5,240 hectares of the Francis Marion National Forest and located about 37 miles northwest of Charleston near Huger, South Carolina. The U.S. Department of Agriculture (USDA) Forest Service maintained a streamflow gaging station on Turkey Creek from 1964 to 1981....

  3. High homogeneity of MAGE, BAGE, GAGE, tyrosinase and Melan-A/MART-1 gene expression in clusters of multiple simultaneous metastases of human melanoma: implications for protocol design of therapeutic antigen-specific vaccination strategies.

    Science.gov (United States)

    Dalerba, P; Ricci, A; Russo, V; Rigatti, D; Nicotra, M R; Mottolese, M; Bordignon, C; Natali, P G; Traversari, C

    1998-07-17

    Human melanoma cells express several antigens which are recognized by autologous and specific CTL clones in association with HLA-class-I molecules. Many of these antigens represent suitable targets for tumor immunotherapy, since their expression in human melanoma cells is common and highly specific. In order to achieve real clinical success with therapeutic vaccination strategies, one important requirement is the expression of the target antigen by all the tumor lesions of a patient. We have studied this issue by assessing, through an RT-PCR approach, the expression of MAGE-1, MAGE-2, MAGE-3, BAGE, GAGE-1/2, Tyrosinase and Melan-A/MART-1 genes in 17 clusters of simultaneous in-transit or regional lymph-node metastases collected from 15 stage-III and 1 stage-IV (AJCC/UICC pTNM system) melanoma patients. In 14 out of 17 clusters of simultaneous metastatic lesions (82%), the homogeneity in the pattern of gene expression within the cluster was complete. Heterogeneity within the same cluster was observed in only 3 out of 17 clusters (18%) and represented only minor features. Our data reveal that, in AJCC-stage-III melanoma patients, different but simultaneous metastatic lesions express the same pattern of antigen-coding genes. These observations have 2 main clinical implications: (i) the antigenic characterization of one single and easily accessible lesion allows identification of optimal targets for an active antigen-specific immunotherapy treatment; (ii) almost all the metastatic lesions are expected to be hit by the immune response eventually induced against the tumor antigen. Moreover, these data suggest that active specific immunotherapy directed against MAGE-1, MAGE-3, BAGE, GAGE-1/2, Melan-A/MART-1 and Tyrosinase antigens could be exploited as an adjuvant treatment to surgery in high-risk AJCC-stage-III-melanoma patients.

  4. Near Net Manufacturing Using Thin Gage Friction Stir Welding

    Science.gov (United States)

    Takeshita, Jennifer; Potter, David; Holquin, Michael

    2006-01-01

    Friction Stir Welding (FSW) and near net spin forming of FSW aluminumn blanks were investigated for large-scale pressure vessel applications. With a specific focus on very thin gage 2xxx and 7xxx aluminum alloys, the program concentrated on the following: the criteria used for material selection, a potential manufacturing flow, and the effectiveness and associated risks of near net spin forming. Discussion will include the mechanical properties of the friction stir welds and the parent material from before and after the spin forming process. This effort was performed under a NASA Space Exploration initiative focused on increasing the affordability, reliability and performance of pressure vessels larger than 10 ft. diameter.

  5. Inclusion Effects on Stress Gage Measurements in Rock and Soil.

    Science.gov (United States)

    1984-05-01

    showed that the line (gage) should not be bonded to the madium. A finite element analysis was made of a typical flatpack stress gagse embedded in grout...density for the foil versus time. As shown, a net expansion of about 71 is obtained, which for our plane symmetry implies the same increase in area. A...expands to a volume of v1 - 0.0332 3 before it starts to move the piston. The expansion comprises the orifice volume (4 inches in diameter, 6 inches

  6. [Expression of MAGE, GAGE, and BAGE genes in human hepatocellular carcinoma].

    Science.gov (United States)

    Shao, Jun-bin; Chen, Zhi

    2003-03-01

    To observe the expression of MAGE, GAGE and BAGE genes in human hepatocellular carcinoma (HCC) cell lines. The expression levels of MAGE-1, MAGE-3, GAGE1-8, GAGE1-2 and BAGE mRNAs in HCC cell lines SMMC-7721, QQY-7701, BEL-7402 were studied by reverse transcription polymerase chain reaction and were compared with those in biopsied liver tissues. MAGE-1 and BAGE mRNAs were expressed in SMMC-7721 cells. MAGE-3 and BAGE mRNAs were expressed in QQY-7701 cells. MAGE-1 and GAGE1-2 mRNAs were expressed in BEL-7402 cells. None of these genes was expressed in biopsied liver tissues. MAGE-1, MAGE-3, GAGE1-8, GAGE1-2 and BAGE are expressed in hepatocellular carcinoma cell lines. These tumor-specific antigens can be used as molecular markers for early diagnosis and possible targets for immunotherapy of human HCC.

  7. A two-stage decentralised system combining high rate activated ...

    African Journals Online (AJOL)

    Total ammonium nitrogen (TAN) and total phosphates (TP) were largely retained in the effluent with average removal percentages of 19.5 and 27.5%, respectively, encouraging reuse for plant growth. Key words: A-stage, sustainable wastewater treatment, resource recovery, developing countries, water reuse, nutrient ...

  8. Field manual for the collection of Navajo Nation streamflow-gage data

    Science.gov (United States)

    Hart, Robert J.; Fisk, Gregory G.

    2014-01-01

    The Field Manual for the Collection of Navajo Nation Streamflow-Gage Data (Navajo Field Manual) is based on established (standard) U.S. Geological Survey streamflow-gaging methods and provides guidelines specifically designed for the Navajo Department of Water Resources personnel who establish and maintain streamflow gages. The Navajo Field Manual addresses field visits, including essential field equipment and the selection of and routine visits to streamflow-gaging stations, examines surveying methods for determining peak flows (indirect measurements), discusses safety considerations, and defines basic terms.

  9. mRNA detection of tumor-rejection genes BAGE, GAGE, and MAGE in peritoneal fluid from patients with ovarian carcinoma as a potential diagnostic tool.

    Science.gov (United States)

    Hofmann, Manfred; Ruschenburg, Ilka

    2002-06-25

    It has been found that the members of the BAGE, MAGE, and GAGE gene families are expressed almost exclusively in neoplastic tissues. Normal tissues, except testis and placenta, are negative. Therefore, the expression of these genes may serve as a useful diagnostic marker in detecting malignant disease. The involvement of the serous cavities by malignant neoplasms has important therapeutic and prognostic implications. Accordingly, the diagnosis of peritoneal spread of ovarian carcinoma plays an important role for both initial and second-look staging procedures. In some patients, however, a definite diagnosis cannot be established by morphologic or immunocytologic examination alone. Detection of tumor specific gene expression may be a sensitive additional tool in these settings. The authors studied the gene expression observed in 44 ascites specimens. Gene expression was evaluated by reverse transcription-polymerase chain reaction analysis and sequencing. Of 44 ascites specimens, the expression of BAGE, MAGE-1, MAGE-3, and GAGE-1/2 was recognized in 17 specimens (63%), 2 specimens (7%), 8 specimens (30%), and 8 specimens (30%) with histologically proven ovarian carcinoma, respectively. Expression of the MAGE and GAGE genes was not observed in patients with nonneoplastic disease, whereas BAGE expression was seen in one patient with cirrhosis. These findings show that testing for BAGE, GAGE-1/2, MAGE-1, and MAGE-3 transcriptional activity in ascites specimens results in high sensitivity in diagnosing malignant ascites. Copyright 2002 American Cancer Society.

  10. A preliminary biomechanical assessment of a polymer composite hip implant using an infrared thermography technique validated by strain gage measurements.

    Science.gov (United States)

    Bougherara, Habiba; Rahim, Ehsan; Shah, Suraj; Dubov, Anton; Schemitsch, Emil H; Zdero, Rad

    2011-07-01

    With the resurgence of composite materials in orthopaedic applications, a rigorous assessment of stress is needed to predict any failure of bone-implant systems. For current biomechanics research, strain gage measurements are employed to experimentally validate finite element models, which then characterize stress in the bone and implant. Our preliminary study experimentally validates a relatively new nondestructive testing technique for orthopaedic implants. Lock-in infrared (IR) thermography validated with strain gage measurements was used to investigate the stress and strain patterns in a novel composite hip implant made of carbon fiber reinforced polyamide 12 (CF/PA12). The hip implant was instrumented with strain gages and mechanically tested using average axial cyclic forces of 840 N, 1500 N, and 2100 N with the implant at an adduction angle of 15 deg to simulate the single-legged stance phase of walking gait. Three-dimensional surface stress maps were also obtained using an IR thermography camera. Results showed almost perfect agreement of IR thermography versus strain gage data with a Pearson correlation of R(2) = 0.96 and a slope = 1.01 for the line of best fit. IR thermography detected hip implant peak stresses on the inferior-medial side just distal to the neck region of 31.14 MPa (at 840 N), 72.16 MPa (at 1500 N), and 119.86 MPa (at 2100 N). There was strong correlation between IR thermography-measured stresses and force application level at key locations on the implant along the medial (R(2) = 0.99) and lateral (R(2) = 0.83 to 0.99) surface, as well as at the peak stress point (R(2) = 0.81 to 0.97). This is the first study to experimentally validate and demonstrate the use of lock-in IR thermography to obtain three-dimensional stress fields of an orthopaedic device manufactured from a composite material.

  11. Detection and Use of Load and Gage Output Repeats of Wind Tunnel Strain-Gage Balance Data

    Science.gov (United States)

    Ulbrich, N.

    2017-01-01

    Criteria are discussed that may be used for the detection of load and gage output repeats of wind tunnel strain-gage balance data. First, empirical thresholds are introduced that help determine if the loads or electrical outputs of a pair of balance calibration or check load data points match. A threshold of 0.01 percent of the load capacity is suggested for the identification of matching loads. Similarly, a threshold of 0.1 microV/V is recommended for the identification of matching electrical outputs. Two examples for the use of load and output repeats are discussed to illustrate benefits of the implementation of a repeat point detection algorithm in a balance data analysis software package. The first example uses the suggested load threshold to identify repeat data points that may be used to compute pure errors of the balance loads. This type of analysis may reveal hidden data quality issues that could potentially be avoided by making calibration process improvements. The second example uses the electrical output threshold for the identification of balance fouling. Data from the calibration of a six-component force balance is used to illustrate the calculation of the pure error of the balance loads.

  12. Validation of the Mayo Clinic Staging System in Determining Prognoses of Patients With Perihilar Cholangiocarcinoma

    NARCIS (Netherlands)

    Coelen, Robert J. S.; Gaspersz, Marcia P.; Labeur, Tim A.; van Vugt, Jeroen L. A.; van Dieren, Susan; Willemssen, François E. J. A.; Nio, Chung Y.; Ijzermans, Jan N. M.; Klümpen, Heinz-Josef; Groot Koerkamp, Bas; van Gulik, Thomas M.

    2017-01-01

    BACKGROUND & AIMS: Most systems for staging perihilar cholangiocarcinoma (PHC) have been developed for the minority of patients with resectable disease. The recently developed Mayo Clinic system for staging PHC requires only clinical and radiologic variables, but has not yet been validated. We

  13. The New Changes In The 7th Ajcc/Uicc Staging System Of Gastric Carcinomas

    Directory of Open Access Journals (Sweden)

    Hălmaciu Ioana

    2013-06-01

    Full Text Available Objective: The aim of this study was to analyze in parallel the 6th and the newest 7th AJJCC/UICC (American Joint Committee on Cancer/ International Union Against Cancer staging system in order to highlight changes brought by the new staging system.

  14. Influence of dispatching rules on average production lead time for multi-stage production systems.

    Science.gov (United States)

    Hübl, Alexander; Jodlbauer, Herbert; Altendorfer, Klaus

    2013-08-01

    In this paper the influence of different dispatching rules on the average production lead time is investigated. Two theorems based on covariance between processing time and production lead time are formulated and proved theoretically. Theorem 1 links the average production lead time to the "processing time weighted production lead time" for the multi-stage production systems analytically. The influence of different dispatching rules on average lead time, which is well known from simulation and empirical studies, can be proved theoretically in Theorem 2 for a single stage production system. A simulation study is conducted to gain more insight into the influence of dispatching rules on average production lead time in a multi-stage production system. We find that the "processing time weighted average production lead time" for a multi-stage production system is not invariant of the applied dispatching rule and can be used as a dispatching rule independent indicator for single-stage production systems.

  15. Controller strategy for a 6 DOF piezoelectric translation stage

    Energy Technology Data Exchange (ETDEWEB)

    Buice, E S; Yang, H; Smith, S T; Hocken, R J; Trumper, D L; Otten, D; Seugling, R M

    2006-03-22

    A controller for the third generation, 6 degree-of-freedom (DOF) piezoelectric translation stage shown in Figure 1 is presented. This was tested by monitoring all six coordinate motions using an orthogonal array of six, high-resolution capacitance gages. The full 6 DOF matrix transformations and controller block diagrams for this system have been measured and the system operated under closed loop control. Results of early experiments to determine the 21 open loop response functions as well as preliminary results showing the closed loop response for the 3 linear translations are presented in this abstract. The ultimate goal of this project is to incorporate this 6 DOF stage within a long range X-Y scanning system for nanometer pick-and-place capability over an area of 50 x 50 mm. The control strategy and early results from this system will be presented.

  16. 49 CFR 213.143 - Frog guard rails and guard faces; gage.

    Science.gov (United States)

    2010-10-01

    ... corresponding location of the tread portion of the track structure. ER22JN98.006 ER22JN98.007 ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.143 Frog guard rails... prescribed in the following table— Class of track Guard check gageThe distance between the gage line of a...

  17. Industrial nuclear gages in permanent installations; Industrielle kontrollkilder i faste installasjoner

    Energy Technology Data Exchange (ETDEWEB)

    Finne, I.E.

    1996-11-01

    The leaflet represents provisions concerning import, sales, installation and use of industrial nuclear gages in permanent installations, together with technical requirements to the radiation source and the source housing. The regulations are directed towards owners and users of nuclear gages, as well as companies working with import, sale, installations and maintenance.

  18. Nickel--chromium strain gages for cryogenic stress analysis of superconducting structures in high magnetic fields

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    Magnetoresistance measurements of strain gages were made. The magnitude and variation of the magnetoresistance of a large number of strain gages were measured for the following conditions: (1) dc magnetic fields up to 12 T, (2) three orthogonal field directions, (3) increasing and decreasing fields, (4) a wide range of strain levels, and (5) liquid helium temperature

  19. Incorporating Tumor Characteristics to the American Joint Committee on Cancer Breast Cancer Staging System.

    Science.gov (United States)

    Chavez-MacGregor, Mariana; Mittendorf, Elizabeth A; Clarke, Christina A; Lichtensztajn, Daphne Y; Hunt, Kelly K; Giordano, Sharon H

    2017-11-01

    The American Joint Committee on Cancer (AJCC) breast cancer staging system provides important prognostic information. The recently published eighth edition incorporates biological markers and recommends the use of a complex "prognostic stage." In this study, we assessed the relationship between stage, breast cancer subtype, grade, and outcome in a large population-based cohort and evaluated a risk score system incorporating tumor characteristic to the AJCC anatomic staging system. Patients diagnosed with primary breast cancer stage I-IV between 2005-2008 were identified in the California Cancer Registry. For patients with stage I-III disease, pathologic stage was recorded. For patients with stage IV disease, clinical stage was utilized. Five-year breast cancer specific survival (BCSS) and overall survival (OS) rates were determined for each potential tumor size-node involvement-metastases (TNM) combination according to breast cancer subtype. A risk score point-based system using grade, estrogen receptor, and human epidermal growth factor receptor 2 (HER2) status was designed to complement the anatomic AJCC staging system. Survival probabilities between groups were compared using log-rank test. Cox proportional hazards models were used. Among 43,938 patients, we observed differences in 5-year BCSS and OS for each TNM combination according to breast cancer subtype. The most favorable outcomes were seen for hormone receptor-positive tumors followed closely by HER2-positive tumors, with the worst outcomes observed for triple negative breast cancer. Our risk score system separated patients into four risk groups within each stage category (all p  system incorporates biological factors into the AJCC anatomic staging system, providing accurate prognostic information. This study demonstrates that stage, but also breast cancer subtype and grade, define prognosis in a large population of breast cancer patients. It shows that a point-based risk score system that incorporates

  20. Two-stage model of development of heterogeneous uranium-lead systems in zircon

    International Nuclear Information System (INIS)

    Mel'nikov, N.N.; Zevchenkov, O.A.

    1985-01-01

    Behaviour of isotope systems of multiphase zircons at their two-stage distortion is considered. The results of calculations testify to the fact that linear correlations on the diagram with concordance can be explained including two-stage discovery of U-Pb systems of cogenetic zircons if zircon is considered physically heterogeneous and losing in its different part different ratios of accumulated radiogenic lead. ''Metamorphism ages'' obtained by these two-stage opening zircons are intermediate, and they not have geochronological significance while ''crystallization ages'' remain rather close to real ones. Two-stage opening zircons in some cases can be diagnosed by discordance of their crystal component

  1. Influence of capacity- and time-constrained intermediate storage in two-stage food production systems

    DEFF Research Database (Denmark)

    Akkerman, Renzo; van Donk, Dirk Pieter; Gaalman, Gerard

    2007-01-01

    In food processing, two-stage production systems with a batch processor in the first stage and packaging lines in the second stage are common and mostly separated by capacity- and time-constrained intermediate storage. This combination of constraints is common in practice, but the literature hardly...... of systems like this. Contrary to the common sense in operations management, the LPT rule is able to maximize the total production volume per day. Furthermore, we show that adding one tank has considerable effects. Finally, we conclude that the optimal setup frequency for batches in the first stage...

  2. Geoscience Workforce Development at UNAVCO: Leveraging the NSF GAGE Facility

    Science.gov (United States)

    Morris, A. R.; Charlevoix, D. J.; Miller, M.

    2013-12-01

    Global economic development demands that the United States remain competitive in the STEM fields, and developing a forward-looking and well-trained geoscience workforce is imperative. According to the Bureau of Labor Statistics, the geosciences will experience a growth of 19% by 2016. Fifty percent of the current geoscience workforce is within 10-15 years of retirement, and as a result, the U.S. is facing a gap between the supply of prepared geoscientists and the demand for well-trained labor. Barring aggressive intervention, the imbalance in the geoscience workforce will continue to grow, leaving the increased demand unmet. UNAVCO, Inc. is well situated to prepare undergraduate students for placement in geoscience technical positions and advanced graduate study. UNAVCO is a university-governed consortium facilitating research and education in the geosciences and in addition UNAVCO manages the NSF Geodesy Advancing Geosciences and EarthScope (GAGE) facility. The GAGE facility supports many facets of geoscience research including instrumentation and infrastructure, data analysis, cyberinfrastructure, and broader impacts. UNAVCO supports the Research Experiences in the Solid Earth Sciences for Students (RESESS), an NSF-funded multiyear geoscience research internship, community support, and professional development program. The primary goal of the RESESS program is to increase the number of historically underrepresented students entering graduate school in the geosciences. RESESS has met with high success in the first 9 years of the program, as more than 75% of RESESS alumni are currently in Master's and PhD programs across the U.S. Building upon the successes of RESESS, UNAVCO is launching a comprehensive workforce development program that will network underrepresented groups in the geosciences to research and opportunities throughout the geosciences. This presentation will focus on the successes of the RESESS program and plans to expand on this success with broader

  3. Using recommender systems to support idea generation stage | El ...

    African Journals Online (AJOL)

    The current paper presents a new use of recommendation systems in the first key activity of the Front End of innovation, and which can assist organizations to improve their ways of generating new ideas. Actually in this paper, we investigate the particular use of recommender systems in the idea generation context to ...

  4. Nickel--chromium strain gages for cryogenic stress analysis of superconducting structures in high magnetic fields

    International Nuclear Information System (INIS)

    Freynik, H.S. Jr.; Roach, D.R.; Deis, D.W.; Hirzel, D.G.

    1977-01-01

    Evaluation and calibration measurements were performed on commercial nickel-chromium metal-foil strain gages in a high-magnetic-field (12 T), liquid-helium (4.2 K) environment. The purpose was to fully characterize strain gages for use at cryogenic temperatures in high magnetic fields. In this study, the magnetoresistance of a number of strain gages was measured in three orthogonal directions at mechanical strain levels to 8900 μm/m. As a result, a unique calibration curve was defined for magnetoresistance strain errors that is independent of strain level and field direction to 12 T at 4.2 K. A current strain-gage application is the measurement of superconductor mechanical properties. These gages will soon be used in the stress analysis of superconducting fusion magnets during cooldown from ambient temperatures and during operation at 4.2 K with magnetic fields to 12 T

  5. Strain measurement technique for elevated temperature tensile and creep testing of foil-gage metals

    Science.gov (United States)

    Blackburn, L. B.

    1988-01-01

    This paper describes a strain measurement technique suitable for elevated-temperature tensile and creep testing of foil-gage metals, using a modified commonly available mechanical extensometer in conjunction with a displacement transducer. The extensometer was modified by attaching to it a counterbalance (to reduce the effect of the extensometer weight on the total maximum test load) and by incorporating a conical tip/flat-edge design (to minimize induced stresses in the specimen resulting from extensometer attachment). Creep tests were performed on 0.102-mm-thick specimens of Ti-6Al-4V at temperatures of 427 and 538 C, at nominal applied stresses of 310.3 and 172.4 MPa, respectively. Examination of the resulting creep curves suggested that the strain measurement system provided actual creep strain values with good accuracy.

  6. The nonlinear stage of gravitational instability in flat gaseous systems

    Energy Technology Data Exchange (ETDEWEB)

    Polyachenko, V.L.; Churilov, S.M.; Shukhman, I.G.

    1980-05-01

    The evolution of finite-amplitude waves in a flat, gaseous, gravitating system is considered. Constraints are placed on the physical state of the gas such that density perturbations can undergo strong growth.

  7. The experimental study of a two-stage photovoltaic thermal system based on solar trough concentration

    International Nuclear Information System (INIS)

    Tan, Lijun; Ji, Xu; Li, Ming; Leng, Congbin; Luo, Xi; Li, Haili

    2014-01-01

    Highlights: • A two-stage photovoltaic thermal system based on solar trough concentration. • Maximum cell efficiency of 5.21% with the mirror opening width of 57 cm. • With single cycle, maximum temperatures rise in the heating stage is 12.06 °C. • With 30 min multiple cycles, working medium temperature 62.8 °C, increased 28.7 °C. - Abstract: A two-stage photovoltaic thermal system based on solar trough concentration is proposed, in which the metal cavity heating stage is added on the basis of the PV/T stage, and thermal energy with higher temperature is output while electric energy is output. With the 1.8 m 2 mirror PV/T system, the characteristic parameters of the space solar cell under non-concentrating solar radiation and concentrating solar radiation are respectively tested experimentally, and the solar cell output characteristics at different opening widths of concentrating mirror of the PV/T stage under condensation are also tested experimentally. When the mirror opening width was 57 cm, the solar cell efficiency reached maximum value of 5.21%. The experimental platform of the two-stage photovoltaic thermal system was established, with a 1.8 m 2 mirror PV/T stage and a 15 m 2 mirror heating stage, or a 1.8 m 2 mirror PV/T stage and a 30 m 2 mirror heating stage. The results showed that with single cycle, the long metal cavity heating stage would bring lower thermal efficiency, but temperature rise of the working medium is higher, up to 12.06 °C with only single cycle. With 30 min closed multiple cycles, the temperature of the working medium in the water tank was 62.8 °C, with an increase of 28.7 °C, and thermal energy with higher temperature could be output

  8. Challenges at different stages of an iris based biometric system

    Directory of Open Access Journals (Sweden)

    Sunil Kumar Singla

    2012-04-01

    Full Text Available Iris recognition has been used for authentication for the past few years and is capable of positive/negative authenticationof an individual without any physical contact or intervention. This technique is being used mainly because of its uniqueness,stability, and reliability but still many challenges are being faced an the iris based recognition system. This paperpresents the difficulties faced in different modules, like the sensor module, preprocessing module, feature extraction module,and matching module of an iris biometric system.

  9. Multi-stage catalyst systems and uses thereof

    Science.gov (United States)

    Ozkan, Umit S [Worthington, OH; Holmgreen, Erik M [Columbus, OH; Yung, Matthew M [Columbus, OH

    2009-02-10

    Catalyst systems and methods provide benefits in reducing the content of nitrogen oxides in a gaseous stream containing nitric oxide (NO), hydrocarbons, carbon monoxide (CO), and oxygen (O.sub.2). The catalyst system comprises an oxidation catalyst comprising a first metal supported on a first inorganic oxide for catalyzing the oxidation of NO to nitrogen dioxide (NO.sub.2), and a reduction catalyst comprising a second metal supported on a second inorganic oxide for catalyzing the reduction of NO.sub.2 to nitrogen (N.sub.2).

  10. Control Issues in Single-Stage Photovoltaic Systems

    DEFF Research Database (Denmark)

    A. Mastromauro, Rosa; Liserre, Marco; Dell’Aquila, Antonio

    2012-01-01

    Photovoltaic Systems (PVS) can be easily integrated in residential buildings hence they will be the main responsible of making low-voltage grid power flow bidirectional. Control issues on both the PV side and on the grid side have received much attention from manufacturers, competing for efficiency...

  11. Advances in high rate anaerobic treatment: staging of reactor systems.

    NARCIS (Netherlands)

    Lier, van J.B.; Zee, van der F.P.; Tan, N.C.G.; Rebac, S.; Kleerebezem, R.

    2001-01-01

    Anaerobic wastewater treatment (AnWT) is considered as the most cost-effective solution for organically polluted industrial waste streams. Particularly the development of high-rate systems, in which hydraulic retention times are uncoupled from solids retention times, has led to a world-wide

  12. Comparison between established and the Worldwide Esophageal Cancer Collaboration staging systems.

    Science.gov (United States)

    Gaur, Puja; Hofstetter, Wayne L; Bekele, B Nebiyou; Correa, Arlene M; Mehran, Reza J; Rice, David C; Roth, Jack A; Vaporciyan, Ara A; Rice, Thomas W; Swisher, Stephen G

    2010-06-01

    Controversy exists regarding the optimal staging system for patients with gastroesophageal junction adenocarcinoma (GEJA). The Worldwide Esophageal Cancer Collaboration (WECC) has organized a multi-institutional database from which a novel esophageal staging system has been organized. We used a single institution experience to validate the hypothesis that the WECC system more accurately predicts survival in GEJA patients than both the American Joint Commission on Cancer 6th edition esophageal and gastric systems. We reviewed 449 GEJA patients (Siewert I-III) treated with neoadjuvant therapy followed by surgery or surgery-alone between 1990 and 2007. A blinded statistician performed a head-to-head comparison regarding the ability of each staging system to predict survival. A subgroup analysis of patients who underwent surgery only (n = 176) was also performed. All three systems predicted survival of patients with GEJA. However, a Bayesian variable selection model found that the WECC system was better than both American Joint Commission on Cancer esophageal and gastric systems (probability 0.99 and 0.98, respectively). Subset analysis suggested that the WECC staging was also optimum for predicting survival in surgery-alone patients. While the esophageal staging system is better at predicting survival than the gastric staging system, the WECC system may be the most favorable single-system predictor of survival for patients with resected GEJA. As suggested by the WECC system, incorporating the number of positive lymph nodes within the staging system may present an advantage in predicting survival. 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  13. Fuel system for diesel engine with multi-stage heated

    Science.gov (United States)

    Ryzhov, Yu N.; Kuznetsov, Yu A.; Kolomeichenko, A. V.; Kuznetsov, I. S.; Solovyev, R. Yu; Sharifullin, S. N.

    2017-09-01

    The article describes a fuel system of a diesel engine with a construction tractor multistage heating, allowing the use of pure rapeseed oil as a diesel engine fuel. The paper identified the kinematic viscosity depending on the temperature and composition of the mixed fuel, supplemented by the existing recommendations on the use of mixed fuels based on vegetable oils and developed the device allowing use as fuel for diesel engines of biofuels based on vegetable oils.

  14. [Application of the 2007 lung cancer staging system by International Association for the Study of Lung Cancer].

    Science.gov (United States)

    Wang, Jia; Wu, Nan; Zheng, Qing-feng; Feng, Yuan; Yan, Shi; Yang, Yue

    2009-08-18

    To compare the prognoses of non-small cell lung cancer patients based respectively on the 6th-Edition Staging System for NSCLC (the 6th-Edition Staging System) and the new staging system by the International Association for the Study of Lung Cancer (IASLC) (new staging system). Data were collected from 136 operated NSCLC patients from Sep. 2003 through Oct. 2007. Those data were staged based respectively on the 6th-Edition Staging System and the new staging system. The 2-year no-recurrence survival rate was calculated, and life span was analyzed using the Kaplan-Meier method of SPSS 13.0 software. (1) In this series, using the 6th-Edition Staging System, there were 56, 23, 53 and 4 patients in stage I, stage II, stage III and stage IV respectively; using the new staging system, there were 50, 31, 54 and 1 patients in stage I, stage II, stage III and stage IV respectively. There were 6 patients in stage I according to the 6th-Edition Staging System who had become 6 patients in stage II according to the new staging system, 1 patient in stage II 1 in stage III, 3 patients in stage III 3 in stage II, 1 patient in stage III 1 in stage IV, and 4 patients in stage IV 4 in stage III. (2) According to the 6th-Edition Staging System, the 2-year no-recurrence survival rates for Ia, Ib, IIa, IIb,IIIa, IIIb and IV were 95.0%, 83.3%, 100.0%, 63.6%, 52.1%, 80.0% and 50.0% respectively, and according to the new staging system, the 2-year cumulative survival rates for I a, Ib, IIa, IIb, IIIa, IIIb and IV were 95.5%, 89.3%, 68.4%, 63.6%, 52.8%, 50.0% and 0.0% respectively. After Chi square analysis, there was no distinguished difference between the 2 staging systems for the 2-year cumulative survival rate. (3) According to the 6th-Edition Staging System, the difference between the no-recurrence rate of stage I and stage II was not statistically significant (P = 0.232), and the difference between the no-recurrence rates of stage II and III was statistically significant(P = 0

  15. Attainability and minimum energy of multiple-stage cascade membrane Systems

    KAUST Repository

    Alshehri, Ali

    2015-08-12

    Process design and simulation of multi-stage membrane systems have been widely studied in many gas separation systems. However, general guidelines have not been developed yet for the attainability and the minimum energy consumption of a multi-stage membrane system. Such information is important for conceptual process design and thus it is the topic of this work. Using a well-mixed membrane model, it was determined that the attainability curve of multi-stage systems is defined by the pressure ratio and membrane selectivity. Using the constant recycle ratio scheme, the recycle ratio can shift the attainability behavior between single-stage and multi-stage membrane systems. When the recycle ratio is zero, all of the multi-stage membrane processes will decay to a single-stage membrane process. When the recycle ratio approaches infinity, the required selectivity and pressure ratio reach their absolute minimum values, which have a simple relationship with that of a single-stage membrane process, as follows: View the MathML sourceSn=S1, View the MathML sourceγn=γ1, where n is the number of stages. The minimum energy consumption of a multi-stage membrane process is primarily determined by the membrane selectivity and recycle ratio. A low recycle ratio can significantly reduce the required membrane selectivity without substantial energy penalty. The energy envelope curve can provide a guideline from an energy perspective to determine the minimum required membrane selectivity in membrane process designs to compete with conventional separation processes, such as distillation.

  16. Dynamic modeling and simulation of a two-stage series-parallel vibration isolation system

    Directory of Open Access Journals (Sweden)

    Rong Guo

    2016-07-01

    Full Text Available A two-stage series-parallel vibration isolation system is already widely used in various industrial fields. However, when the researchers analyze the vibration characteristics of a mechanical system, the system is usually regarded as a single-stage one composed of two substructures. The dynamic modeling of a two-stage series-parallel vibration isolation system using frequency response function–based substructuring method has not been studied. Therefore, this article presents the source-path-receiver model and the substructure property identification model of such a system. These two models make up the transfer path model of the system. And the model is programmed by MATLAB. To verify the proposed transfer path model, a finite element model simulating a vehicle system, which is a typical two-stage series-parallel vibration isolation system, is developed. The substructure frequency response functions and system level frequency response functions can be obtained by MSC Patran/Nastran and LMS Virtual.lab based on the finite element model. Next, the system level frequency response functions are substituted into the transfer path model to predict the substructural frequency response functions and the system response of the coupled structure can then be further calculated. By comparing the predicted results and exact value, the model proves to be correct. Finally, the random noise is introduced into several relevant system level frequency response functions for error sensitivity analysis. The system level frequency response functions that are most sensitive to the random error are found. Since a two-stage series-parallel system has not been well studied, the proposed transfer path model improves the dynamic theory of the multi-stage vibration isolation system. Moreover, the validation process of the model here actually provides an example for acoustic and vibration transfer path analysis based on the proposed model. And it is worth noting that the

  17. Creation of an Upper Stage Trajectory Capability Boundary to Enable Booster System Trade Space Exploration

    Science.gov (United States)

    Walsh, Ptrick; Coulon, Adam; Edwards, Stephen; Mavris, Dimitri N.

    2012-01-01

    The problem of trajectory optimization is important in all space missions. The solution of this problem enables one to specify the optimum thrust steering program which should be followed to achieve a specified mission objective, simultaneously satisfying the constraints.1 It is well known that whether or not the ascent trajectory is optimal can have a significant impact on propellant usage for a given payload, or on payload weight for the same gross vehicle weight.2 Consequently, ascent guidance commands are usually optimized in some fashion. Multi-stage vehicles add complexity to this analysis process as changes in vehicle properties in one stage propagate to the other stages through gear ratios and changes in the optimal trajectory. These effects can cause an increase in analysis time as more variables are added and convergence of the optimizer to system closure requires more analysis iterations. In this paper, an approach to simplifying this multi-stage problem through the creation of an upper stage capability boundary is presented. This work was completed as part of a larger study focused on trade space exploration for the advanced booster system that will eventually form a part of NASA s new Space Launch System.3 The approach developed leverages Design of Experiments and Surrogate Modeling4 techniques to create a predictive model of the SLS upper stage performance. The design of the SLS core stages is considered fixed for the purposes of this study, which results in trajectory parameters such as staging conditions being the only variables relevant to the upper stage. Through the creation of a surrogate model, which takes staging conditions as inputs and predicts the payload mass delivered by the SLS upper stage to a reference orbit as the response, it is possible to identify a "surface" of staging conditions which all satisfy the SLS requirement of placing 130 metric tons into low-Earth orbit (LEO).3 This identified surface represents the 130 metric ton

  18. Single-Stage, Gelled Hydrazine System for Mars Ascent Vehicle Propulsion, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Microcosm, Inc. in cooperation with Aerojet Rocketdyne is presenting an innovative approach to the Mars Ascent Vehicle (MAV). The single-stage monopropellant system...

  19. Replacement of chromates in paints and corrosion protection systems [Stage 2

    Science.gov (United States)

    2004-05-01

    This technical report presents the second stage results of a multi-year project to develop chromate-free paints and corrosion protection systems. Chromate-containing coatings and paints are very effective in providing corrosion resistance and are wid...

  20. Replacement of chromates in paints and corrosion protection systems [Stage 1

    Science.gov (United States)

    2004-05-01

    This technical report presents the first stage results of a multi-year project to develop chromate-free paints and corrosion protection systems. Chromate coatings and chromate-containing paints are very effective in providing corrosion resistance and...

  1. [Comparison of differentiated thyroid carcinoma staging systems in a Spanish population].

    Science.gov (United States)

    Andía Melero, Víctor Manuel; Martín de Santa-Olalla Llanes, María; Sambo Salas, Marcel; Percovich Hualpa, Juan Carlos; Motilla de la Cámara, Marta; Collado Yurrita, Luis

    2015-04-01

    Differentiated thyroid carcinoma staging is increasingly important due to the current trends to a less intensive therapy in low-risk patients. The TNM system is most widely used, but other systems based on follow-up of several patient cohorts have been developed. When these systems have been applied to other populations, results have been discordant. Our study evaluates the suitability of several differentiated thyroid carcinoma staging systems in a Spanish population. 729 patients with differentiated thyroid carcinoma and staging data available were enrolled. Mean follow-up time was 10.8 years. The TNM, EORTC, AMES, Clinical class, MACIS, Ohio, NTCTCS, and Spanish systems were applied to all histological types. The Kaplan-Meier survival curves for each system were analyzed, and compared using the proportion of explained variation (PEV). The demographic and clinical characteristics of our population were similar to those of other Spanish and international cohorts reported. The best systems were NTCTCS, with 74.7% PEV, and TNM (68.3%), followed by the Ohio, MACIS, EORTC, and AMES systems with minimal differences between them, while the least adequate were the Spanish (55.2%) and Clinical class (47.1%) systems. The NTCTCS staging system was found to be better than TNM in our population but, because of its simplicity and greater dissemination, the TNM appears to be recommended for staging of patients with differentiated thyroid carcinoma. Copyright © 2014 SEEN. Published by Elsevier España, S.L.U. All rights reserved.

  2. Reassessing the NTCTCS Staging Systems for Differentiated Thyroid Cancer, Including Age at Diagnosis

    Science.gov (United States)

    McLeod, Donald S.A.; Jonklaas, Jacqueline; Brierley, James D.; Ain, Kenneth B.; Cooper, David S.; Fein, Henry G.; Haugen, Bryan R.; Ladenson, Paul W.; Magner, James; Ross, Douglas S.; Skarulis, Monica C.; Steward, David L.; Xing, Mingzhao; Litofsky, Danielle R.; Maxon, Harry R.

    2015-01-01

    Background: Thyroid cancer is unique for having age as a staging variable. Recently, the commonly used age cut-point of 45 years has been questioned. Objective: This study assessed alternate staging systems on the outcome of overall survival, and compared these with current National Thyroid Cancer Treatment Cooperative Study (NTCTCS) staging systems for papillary and follicular thyroid cancer. Methods: A total of 4721 patients with differentiated thyroid cancer were assessed. Five potential alternate staging systems were generated at age cut-points in five-year increments from 35 to 70 years, and tested for model discrimination (Harrell's C-statistic) and calibration (R2). The best five models for papillary and follicular cancer were further tested with bootstrap resampling and significance testing for discrimination. Results: The best five alternate papillary cancer systems had age cut-points of 45–50 years, with the highest scoring model using 50 years. No significant difference in C-statistic was found between the best alternate and current NTCTCS systems (p = 0.200). The best five alternate follicular cancer systems had age cut-points of 50–55 years, with the highest scoring model using 50 years. All five best alternate staging systems performed better compared with the current system (p = 0.003–0.035). There was no significant difference in discrimination between the best alternate system (cut-point age 50 years) and the best system of cut-point age 45 years (p = 0.197). Conclusions: No alternate papillary cancer systems assessed were significantly better than the current system. New alternate staging systems for follicular cancer appear to be better than the current NTCTCS system, although they require external validation. PMID:26203804

  3. A new system for assessment of growth using mandibular canine calcification stages and its correlation with modified MP3 stages

    Directory of Open Access Journals (Sweden)

    Gautham Hegde

    2014-01-01

    Full Text Available Objective: Orthodontic diagnosis and treatment planning for growing children must involve growth prediction, especially in the treatment of skeletal problems. Studies have shown that a strong association exists between skeletal maturity and dental calcification stages. The present study was therefore taken up to provide a simple and practical method for assessing skeletal maturity using a dental periapical film and standard dental X-ray machine, to compare the developmental stages of the mandibular canine with that of developmental stages of modified MP3 and to find out if any correlation exists, to determine if the developmental stages of the mandibular canine alone can be used as a reliable indicator for assessment of skeletal maturity. Materials and Methods: A total of 160 periapical radiographs, of the mandibular right canine and the MP3 region was taken and assessed according to the Dermirjian′s stages of dental calcification and the modified MP3 stages. Results and Discussion: The correlation coefficient between MP3 stages and developmental stages of mandibular canine was found to be significant in both male and female groups. When the canine calcification stages were compared with the MP3 stages it was found that with the exception of the D stage of canine calcification the remaining stages showed a very high correlation with the modified MP3 stages. Conclusion: The correlation between the mandibular canine calcification stages, and the MP3 stages was found to be significant. The canine calcification could be used as a sole indicator for assessment of skeletal maturity.

  4. A study of the effect of apparent strain on thermal stress measurement for two types of elevated temperature strain gages

    Science.gov (United States)

    Jenkins, J. M.

    1983-01-01

    A weldable type strain gage was used to measure low level thermal stress in an elevated temperature environment. Foil strain gages used in a comparative manner reveal that the apparent strain of weldable strain gages is not sufficiently known to acquire accurate low level thermal stress data. Apparent strain data acquired from coupon tests reveals a large scatter in apparent strain characteristics among the weldable strain gages. It is concluded that apparent strain data for individual weldable strain gages must be required prior to installation if valid thermal stress data is to be obtained through the temperature range of room temperature to 755 K (900 F).

  5. The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system.

    Science.gov (United States)

    Jurberg, Arnon D; Gonçalves, Tiana; Costa, Tatiane A; de Mattos, Ana Carolina A; Pascarelli, Bernardo M; de Manso, Pedro Paulo A; Ribeiro-Alves, Marcelo; Pelajo-Machado, Marcelo; Peralta, José M; Coelho, Paulo Marcos Z; Lenzi, Henrique L

    2009-05-01

    Schistosomiasis is a water-borne parasitic illness caused by neoophoran trematodes of the genus Schistosoma. Using classical histological techniques and whole-mount preparations, the present work describes the embryonic development of Schistosoma mansoni eggs in the murine host and compares it with eggs maintained under in vitro conditions. Two pre-embryonic stages occur inside the female worm: the prezygotic stage is characterized by the release of mature oocytes from the female ovary until its fertilization. The zygotic stage encompasses the migration of the zygote through the ootype, where the eggshell is formed, to the uterus. Fully formed eggs are laid still undeveloped, without having suffered any cleavage. In the outside environment, eight embryonic stages can be defined: stage 1 refers to early cleavages and the beginning of yolk fusion. Stage 2 represents late cleavage, with the formation of a stereoblastula and the onset of outer envelope differentiation. Stage 3 is defined by the elongation of the embryonic primordium and the onset of inner envelope formation. At stage 4, the first organ primordia arise. During stages 5 to 7, tissue and organ differentiation occurs (neural mass, epidermis, terebratorium, musculature, and miracidial glands). Stage 7 is characterized by the nuclear condensation of neurons of the central neural mass. Stage 8 refers to the fully formed larva, presenting muscular contraction, cilia, and flame-cell beating. This staging system was compared to a previous classification and could underlie further studies on egg histoproteomics (morphological localizome). The differentiation of embryonic structures and their probable roles in granulomatogenesis are discussed herein.

  6. Combustion of coked sand in a two-stage fluidized bed system

    Energy Technology Data Exchange (ETDEWEB)

    Coronella, C.J.; Seader, J.D. (University of Utah, Salt Lake City, UT (USA). Dept. of Chemical Engineering)

    1992-02-01

    An advanced multiple-stage fluidized bed reactor system has been devised for the energy-efficient extraction and conversion, from tar sand, of bitumen into synthetic crude oil. The reactor consists of four fluidized beds arranged as stages in series with respect to flow of sand. In the first stage, tar sands are heated, causing the bitumen to pyrolyse into coke, which is deposited on the sand, and gas, which is mostly condensed into oil. The coke is partially combusted with air or enriched oxygen in the second stage, which is thermally coupled to the first stage by multiple vertical heat pipes. Combustion is completed adiabatically in the third stage and heat recovery from the sand is carried out in the fourth stage. By conducting the coke combustion in two stages in this manner, the overall reactor residence time to produce clean sand is greatly reduced from that for a single combustion stage. Laboratory experimental studies have confirmed the ability to operate and control the two thermally coupled stages. The two-phase bubbling bed model of Grace, amended to account for bubble growth in the axial direction, has been adopted to model the mass transfer and fluid mechanics of the fluidized beds. The model for the first and second combustion stages is complete. Predictions for exit reactor conditions at various operating conditions are in reasonable agreement with experimental observations. The operating parameters have been found to exert a much greater influence on the predictions of the model than do the values of the physical parameters, indicating a desirable degree of reactor stability. Extension of the model to the pyrolysis and heat recovery stages will permit the optimization of the reactor configuration and operating conditions. 26 refs., 6 figs.

  7. A two-stage stochastic programming approach for operating multi-energy systems

    DEFF Research Database (Denmark)

    Zeng, Qing; Fang, Jiakun; Chen, Zhe

    2017-01-01

    This paper provides a two-stage stochastic programming approach for joint operating multi-energy systems under uncertainty. Simulation is carried out in a test system to demonstrate the feasibility and efficiency of the proposed approach. The test energy system includes a gas subsystem with a gas...

  8. Measurement of large ground motions with the ASM gage

    International Nuclear Information System (INIS)

    Wright, B.L.; Alrick, K.R.; Fritz, J.N.

    1994-01-01

    Conversion of the energy from undergound explosions to distant seismic signals involves hydrodynamic flows sampling a wide range of pressures. For lower pressures a larger portion of the initial wave motion must be measured to obtain definitive results. The intermediate pressure range, where the initial wave is strong enough to destroy most instrumentation but does not contain definitive information in its initial amplitude, presents special difficulties. We present design considerations for an experiment implementing the ASM gage principle (induction of eddy currents in a moving conducting plate) that can sample wave motion for many milliseconds. In essence we hang a large metal plate (large in area) on a wall and watch the free-surface release. This is not an in-itu measurement of the wave profile because the incoming wave is modififed by the release propagating backward from the wall. However, this a relatively clean modification of the incoming wave and is a situation commonly handled in many shock-wave experiments. copyright American Institute of Physics

  9. [Retrospective analysis of 47 cases with hilar cholangiocarcinoma using T-staging system].

    Science.gov (United States)

    Peng, Cheng-hong; Zhao, Zhi-ming; Peng, Shu-you; Liu, Ying-bin; Wu, Yü-lian; Fang, He-qing; Jiang, Xian-chuan

    2005-01-01

    To evaluate the clinical value of T-staging system for hilar cholangiocarcinoma which was adopted in memorial Sloan-Kettering cancer center of New York. The image data of these 47 patients were analyzed retrospectively from December 1997 to December 2002 whose data were according with our demand, and they were staged into three-stage according to the criteria of the T-staging system. The difference of respectability, ratio of tumor-free resection margin and actuarial survival rate were analyzed for different T-staging. And the coincident ratio of three different kinds of imaging methods was also analyzed. Twenty patients had T(1) tumors, twenty three had T(2) tumors and four had T(3) tumors. The resectability of the three stage was 60%, 39% and 0% respectively, and the difference was significant (P = 0.013). The likelihood of achieving tumor-free margin decreased progressively with increasing T stage (P = 0.018). The cumulative 1-year survival rates of T(1), T(2) and T(3) patients were 60%, 39% and 0% respectively, and the cumulative 3-year survival rate was 35%, 9% and 0% respectively, the survival of different stage patients differed markedly (P = 0.0103). The coincident ratio of combined using MRCP and color Doppler-ultrasonography was higher than that of combined using MRCP and B-ultrasonography or combined using CT/SCT and color Doppler-ultrasonography (P = 0.007). The T-staging system has a better value for preoperative assessment, and can be used to judge resectability and survival of hilar cholangiocarcinoma. It will be helpful to use MRCP and color Doppler-Ultrasonography combined to verdict the coverage of the tumor and the T-staging preoperatively.

  10. GAGE cancer-germline antigens bind DNA and are recruited to the nuclear envelope by Germ cell-less

    DEFF Research Database (Denmark)

    Gjerstorff, Morten; Rösner, Heike; Pedersen, Christina Bøg

    GAGE genes encode a highly similar, primate-specific protein family with unique primary structure and undefined roles in germ cells, various fetal cells and cancer cells. We report that GAGE proteins are intrinsically disordered proteins that provide novel interfaces between chromatin and the nuc......GAGE genes encode a highly similar, primate-specific protein family with unique primary structure and undefined roles in germ cells, various fetal cells and cancer cells. We report that GAGE proteins are intrinsically disordered proteins that provide novel interfaces between chromatin...... and the nuclear envelope. Structural analysis by NMR and CD spectroscopy showed GAGE proteins lack distinct secondary or tertiary structure and are therefore intrinsically disordered. In normal cells and cancer cells GAGE proteins localize predominantly in the nucleus; we found GAGE proteins formed stable...... complexes with dsDNA at sub-physiological concentrations. GAGE12I bound several different dsDNA fragments, suggesting sequence-independent binding. GAGE1, GAGE2B and GAGE12I associated directly or indirectly with Germ cell-less (GCL), which directly binds LEM-domain proteins (LAP2β, emerin, MAN1...

  11. A Three-Stage Optimal Approach for Power System Economic Dispatch Considering Microgrids

    Directory of Open Access Journals (Sweden)

    Wei-Tzer Huang

    2016-11-01

    Full Text Available The inclusion of microgrids (MGs in power systems, especially distribution-substation-level MGs, significantly affects power systems because of the large volumes of import and export power flows. Consequently, power dispatch has become complicated, and finding an optimal solution is difficult. In this study, a three-stage optimal power dispatch model is proposed to solve such dispatch problems. In the proposed model, the entire power system is divided into two parts, namely, the main power grid and MGs. The optimal power dispatch problem is resolved on the basis of multi-area concepts. In stage I, the main power system economic dispatch (ED problem is solved by sensitive factors. In stage II, the optimal power dispatches of the local MGs are addressed via an improved direct search method. In stage III, the incremental linear models for the entire power system can be established on the basis of the solutions of the previous two stages and can be subjected to linear programming to determine the optimal reschedules from the original dispatch solutions. The proposed method is coded using Matlab and tested by utilizing an IEEE 14-bus test system to verify its feasibility and accuracy. Results demonstrated that the proposed approach can be used for the ED of power systems with MGs as virtual power plants.

  12. Solar Multi-stage Refrigeration Systems on the Basis of Absorber with the Internal Evaporative Cooling

    Directory of Open Access Journals (Sweden)

    Doroshenko A.V.

    2015-08-01

    Full Text Available In the article, the developed schematics are presented for the alternative refrigeration systems and air-conditioning systems, based on the use of absorbing cycle and solar energy for the regeneration of absorbent solution. Multi-stage principle of construction of drying and cool contours of solar systems is used with growth of concentration of absorbent on the stages of cooler. An absorber with internal evaporative cooling, allowing to remove the separate evaporated cooler, usually included after the absorber of the proper stage, is developed. Heat-mass-transfer apparatus of film-type, entering in the complement of drying and cool contours compatible and executed on the basis of multichannel compositions from polymeric materials. The preliminary comparative analysis of possibilities of the solar refrigeration systems and air-conditioning systems is executed.

  13. United States Geological Survey discharge data from five example gages on intermittent streams

    Data.gov (United States)

    U.S. Environmental Protection Agency — The data are mean daily discharge data at United States Geological Survey gages. Once column provides the date (mm/dd/yyyy) and the other column provides the mean...

  14. An introduction to NH-A neutron earth base moisture gage

    International Nuclear Information System (INIS)

    Zhu Huaian; Jiang Yulan; Yin Xilin; Yu Peiying; Luo Pinjie

    1988-01-01

    NH-A neutron earth base moisture gage is an accurate instrument which can measure earth moisture rapidly and non-destructively and display moisture results immediately. The deviation is estimated at ±0.012g/cm

  15. Portable neutron moisture gage for the moisture determination of structure parts

    International Nuclear Information System (INIS)

    Harnisch, M.

    1985-01-01

    For determining the moisture of structure parts during building or before repairing a portable neutron moisture gage consisting of a neutron probe and pulse analyzer has been developed. The measuring process, calibration, and prerequisites of application are briefly discussed

  16. A Lymph Node Staging System for Gastric Cancer: A Hybrid Type Based on Topographic and Numeric Systems.

    Directory of Open Access Journals (Sweden)

    Yoon Young Choi

    Full Text Available Although changing a lymph node staging system from an anatomically based system to a numerically based system in gastric cancer offers better prognostic performance, several problems can arise: it does not offer information on the anatomical extent of disease and cannot represent the extent of lymph node dissection. The purpose of this study was to discover an alternative lymph node staging system for gastric cancer. Data from 6025 patients who underwent gastrectomy for primary gastric cancer between January 2000 and December 2010 were reviewed. The lymph node groups were reclassified into lesser-curvature, greater-curvature, and extra-perigastric groups. Presence of any metastatic lymph node in one group was considered positive. Lymph node groups were further stratified into four (new N0-new N3 according to the number of positive lymph node groups. Survival outcomes with this new N staging were compared with those of the current TNM system. For validation, two centers in Japan (large center, n = 3443; medium center, n = 560 were invited. Even among the same pN stages, the more advanced new N stage showed worse prognosis, indicating that the anatomical extent of metastatic lymph nodes is important. The prognostic performance of the new staging system was as good as that of the current TNM system for overall advanced gastric cancer as well as lymph node-positive gastric cancer (Harrell C-index was 0.799, 0.726, and 0.703 in current TNM and 0.799, 0.727, and 0.703 in new TNM stage. Validation sets supported these outcomes. The new N staging system demonstrated prognostic performance equal to that of the current TNM system and could thus be used as an alternative.

  17. Evaluation of the World Health Organization staging system for HIV infection and disease in Ethiopia: association between clinical stages and laboratory markers

    NARCIS (Netherlands)

    Kassa, E.; Rinke de Wit, T. F.; Hailu, E.; Girma, M.; Messele, T.; Mariam, H. G.; Yohannes, S.; Jurriaans, S.; Yeneneh, H.; Coutinho, R. A.; Fontanet, A. L.

    1999-01-01

    OBJECTIVE: To study the association between the clinical axis of the World Health Organization (WHO) staging system of HIV infection and disease and laboratory markers in HIV-infected Ethiopians. DESIGN: Cross-sectional study. METHODS: Clinical manifestations and stage of HIV-positive individuals

  18. Development of Displacement Gages Exposed to Solid Rocket Motor Internal Environments

    Science.gov (United States)

    Bolton, D. E.; Cook, D. J.

    2003-01-01

    The Space Shuttle Reusable Solid Rocket Motor (RSRM) has three non-vented segment-to-segment case field joints. These joints use an interference fit J-joint that is bonded at assembly with a Pressure Sensitive Adhesive (PSA) inboard of redundant O-ring seals. Full-scale motor and sub-scale test article experience has shown that the ability to preclude gas leakage past the J-joint is a function of PSA type, joint moisture from pre-assembly humidity exposure, and the magnitude of joint displacement during motor operation. To more accurately determine the axial displacements at the J-joints, two thermally durable displacement gages (one mechanical and one electrical) were designed and developed. The mechanical displacement gage concept was generated first as a non-electrical, self-contained gage to capture the maximum magnitude of the J-joint motion. When it became feasible, the electrical displacement gage concept was generated second as a real-time linear displacement gage. Both of these gages were refined in development testing that included hot internal solid rocket motor environments and simulated vibration environments. As a result of this gage development effort, joint motions have been measured in static fired RSRM J-joints where intentional venting was produced (Flight Support Motor #8, FSM-8) and nominal non-vented behavior occurred (FSM-9 and FSM-10). This data gives new insight into the nominal characteristics of the three case J-joint positions (forward, center and aft) and characteristics of some case J-joints that became vented during motor operation. The data supports previous structural model predictions. These gages will also be useful in evaluating J-joint motion differences in a five-segment Space Shuttle solid rocket motor.

  19. Structural integration of separation and reaction systems: I. Integration of stage-wise processes

    Directory of Open Access Journals (Sweden)

    Mitrović Milan

    2002-01-01

    Full Text Available The structural integration of separation processes, using multifunctional equipment, has been studied on four stage-wise liquid-liquid separations extraction, absorption, distillation, adsorption and on some combinations of these processes. It was shown for stage - wise processes that the ultimate aim of equipment integration is 3-way integration (by components by steps and by stages and that membrane multiphase contactors present concerning the equipment optimal solutions in many cases. First, by using partially integrated equipment and, later by developing fully integrated systems it was experimentally confirmed that structural 3-way integration produces much higher degrees of component separations and component enrichments in compact and safe equipment.

  20. Decomposed versus integrated control of a one-stage production system

    NARCIS (Netherlands)

    Sierksma, G.; Wijngaard, J.

    1999-01-01

    This paper considers the case of a one-stage production system with several products and operating under tight production capacity constraints. The production schedule is cyclical, and there are long and sequence dependent setup times. The production system is regarded to consist of two components,

  1. Proposal for a new staging system for osteoradionecrosis of the mandible

    NARCIS (Netherlands)

    Karagozoglu, K.H.; Dekker, H.A.; Rietveld, D.; de Bree, R.; Schulten, E.A.J.M.; Kantola, S.; Forouzanfar, T.; van der Waal, I.

    2014-01-01

    A new staging system for osteoradionecrosis of the mandible has been retrospectively applied to a group of 31 patients. In this system clinicoradiographic signs and symptoms are incorporated in a simplified manner. For imaging purposes the use of plain radiographs such as periapical films and

  2. A two-stage stochastic programming model for the optimal design of distributed energy systems

    International Nuclear Information System (INIS)

    Zhou, Zhe; Zhang, Jianyun; Liu, Pei; Li, Zheng; Georgiadis, Michael C.; Pistikopoulos, Efstratios N.

    2013-01-01

    Highlights: ► The optimal design of distributed energy systems under uncertainty is studied. ► A stochastic model is developed using genetic algorithm and Monte Carlo method. ► The proposed system possesses inherent robustness under uncertainty. ► The inherent robustness is due to energy storage facilities and grid connection. -- Abstract: A distributed energy system is a multi-input and multi-output energy system with substantial energy, economic and environmental benefits. The optimal design of such a complex system under energy demand and supply uncertainty poses significant challenges in terms of both modelling and corresponding solution strategies. This paper proposes a two-stage stochastic programming model for the optimal design of distributed energy systems. A two-stage decomposition based solution strategy is used to solve the optimization problem with genetic algorithm performing the search on the first stage variables and a Monte Carlo method dealing with uncertainty in the second stage. The model is applied to the planning of a distributed energy system in a hotel. Detailed computational results are presented and compared with those generated by a deterministic model. The impacts of demand and supply uncertainty on the optimal design of distributed energy systems are systematically investigated using proposed modelling framework and solution approach.

  3. A clinical staging system and treatment guidelines for maxillary osteoradionecrosis in irradiated nasopharyngeal carcinoma patients

    International Nuclear Information System (INIS)

    Cheng, S.-J.; Lee, J.-J.; Ting, L.-L.; Tseng, I.-Y.; Chang, H.-H.; Chen, H.-M.; Kuo, Y.-S.; Hahn, L.-J.; Kok, S.-H.

    2006-01-01

    Purpose: To develop a clinical staging system for maxillary osteoradionecrosis (ORN) in irradiated nasopharyngeal carcinoma (NPC) patients. Methods and Materials: The data of maxillary ORN cases among 1,758 irradiated NPC patients were analyzed. A staging system based on the degrees of bone exposure (E), infection (I), and bleeding (B) was developed. Correlations between various clinical parameters and stages of maxillary ORN and relationships between treatment modalities and outcomes at each stage were evaluated. Cumulative success of treatment and risk factors that affect treatment outcomes were analyzed. Results: The incidence of maxillary ORN was 2.7% (48/1,758). TNM stage of NPC (p < 0.001), radiation dose (p = 0.029), and tooth extraction (p < 0.001) appeared to have significant influences on disease severity. Success rates between conservative therapy and surgical treatment were not significantly different for Stage I ORN but differed significantly for Stage II (p = 0.013) and Stage III (p = 0.008) lesions. Grade 3 infection and bleeding significantly jeopardized treatment success (p = 0.043 and 0.015, respectively). The risk ratios of treatment failure for Grade 3 infection and bleeding were 2.523 (p = 0.034) and 3.141 (p = 0.027), respectively. Conclusions: More serious maxillary ORN tended to occur in cases with more advanced NPC, higher radiation dose, and history of tooth extraction. Surgical treatment was usually required in Stage II and III ORN. The grades of infection and bleeding are important factors in guidance of treatment and prediction of outcomes

  4. A theoretical analysis of price elasticity of energy demand in multi-stage energy conversion systems

    International Nuclear Information System (INIS)

    Lowe, Robert

    2003-01-01

    The objective of this paper is an analytical exploration of the problem of price elasticity of energy demand in multi-stage energy conversion systems. The paper describes in some detail an analytical model of energy demand in such systems. Under a clearly stated set of assumptions, the model makes it possible to explore both the impacts of the number of sub-systems, and of varying sub-system elasticities on overall system elasticity. The analysis suggests that overall price elasticity of energy demand for such systems will tend asymptotically to unity as the number of sub-systems increases

  5. Production system and harvesting stage influence on nitrate content and quality of butterhead lettuce

    Directory of Open Access Journals (Sweden)

    Siti Fairuz Yosoff

    2015-01-01

    Full Text Available Leafy vegetables such as lettuce grown under different production systems may accumulate different concentrations of nitrate which may reach to the levels potentially toxic to humans. Moreover, nitrate accumulation varies in various plant parts and physiological age of the plant. Therefore, to determine the effect of production system and harvesting stage on nitrate accumulation and quality of butterhead lettuce, a study was conducted considering two lettuce production systems namely hydroponic and organic, and four different harvesting stages such as 35, 38, 41 and 44 days after transplanting (DAT. The experimental design was complete randomized design (CRD with four replications. Hydroponic and organic systems performed similar in terms of yield, quality and nitrate content of butterhead lettuce. Delaying harvesting can not only increase yield but also can minimize nitrate accumulation and health hazard risk as well. Delay in harvesting stage may result in quality deterioration of lettuce and increased production cost. Thus, a compromise is necessary to consider 41 DAT as the optimum stage to harvest butterhead lettuce with significantly higher reduction of nitrate content in both outer adult leaf blades and young leaves of hydroponic lettuce. Fresh weight, firmness and color of butterhead lettuce at this stage were still acceptable.

  6. A Two-stage DC-DC Converter for the Fuel Cell-Supercapacitor Hybrid System

    DEFF Research Database (Denmark)

    Zhang, Zhe; Thomsen, Ole Cornelius; Andersen, Michael A. E.

    2009-01-01

    A wide input range multi-stage converter is proposed with the fuel cells and supercapacitors as a hybrid system. The front-end two-phase boost converter is used to optimize the output power and to reduce the current ripple of fuel cells. The supercapacitor power module is connected by push......-pull-forward half bridge (PPFHB) converter with coupled inductors in the second stage to handle the slow transient response of the fuel cells and realize the bidirectional power flow control. Moreover, this cascaded structure simplifies the power management. The control strategy for the whole system is analyzed...... and designed. A 1kW prototype controlled by TMS320F2808 DSP is built in the lab. Simulation and experimental results confirm the feasibility of the proposed two stage dc-dc converter system....

  7. An intracooling system for a novel two-stage sliding-vane air compressor

    Science.gov (United States)

    Murgia, Stefano; Valenti, Gianluca; Costanzo, Ida; Colletta, Daniele; Contaldi, Giulio

    2017-08-01

    Lube-oil injection is used in positive-displacement compressors and, among them, in sliding-vane machines to guarantee the correct lubrication of the moving parts and as sealing to prevent air leakage. Furthermore, lube-oil injection allows to exploit lubricant also as thermal ballast with a great thermal capacity to minimize the temperature increase during the compression. This study presents the design of a two-stage sliding-vane rotary compressor in which the air cooling is operated by high-pressure cold oil injection into a connection duct between the two stages. The heat exchange between the atomized oil jet and the air results in a decrease of the air temperature before the second stage, improving the overall system efficiency. This cooling system is named here intracooling, as opposed to intercooling. The oil injection is realized via pressure-swirl nozzles, both within the compressors and inside the intracooling duct. The design of the two-stage sliding-vane compressor is accomplished by way of a lumped parameter model. The model predicts an input power reduction as large as 10% for intercooled and intracooled two-stage compressors, the latter being slightly better, with respect to a conventional single-stage compressor for compressed air applications. An experimental campaign is conducted on a first prototype that comprises the low-pressure compressor and the intracooling duct, indicating that a significant temperature reduction is achieved in the duct.

  8. Understanding cancer staging

    Science.gov (United States)

    ... detailed information about the cancer stage. TNM Staging System The most common system for staging cancer in the form of solid tumor is the TNM system. Most providers and cancer centers use it to stage ...

  9. Validation of a new prognostic staging system for hepatocellular carcinoma: a comparison of the biomarker-combined Japan Integrated Staging Score, the conventional Japan Integrated Staging Score and the BALAD Score.

    Science.gov (United States)

    Kitai, Satoshi; Kudo, Masatoshi; Minami, Yasunori; Haji, Seiji; Osaki, Yukio; Oka, Hiroko; Seki, Toshihito; Kasugai, Hiroshi; Sasaki, Yo; Matsunaga, Takashi

    2008-01-01

    The conventional Japan Integrated Staging (c-JIS) score has been reported to effectively stratify patients with hepatocellular carcinoma (HCC). Recently, two new staging systems, the biomarker-combined JIS (bm-JIS) score and the BALAD score, have been proposed. Both staging systems include three tumor markers: alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive AFP and des-gamma-carboxy prothrombin specific for HCC. The aim of this study is to evaluate the performance of these three staging systems. A total of 1,173 HCC patients were included in this study. The stratification ability and prognostic predictive power were compared between these three staging systems. These three staging systems effectively predicted the patient survival. When accounting for the best prognostic subgroup of each staging systems (i.e. score of 0), there were significant differences between the bm-JIS score and the BALAD score and, likewise, between the c-JIS score and the BALAD score. The likelihood ratio chi(2) test showed the highest value and the Akaike information criterion value was lowest in the bm-JIS score. The bm-JIS score showed good stratification ability and was thus demonstrated to be a better predictor of the prognosis than the c-JIS score and the BALAD score, especially for the patients with a good prognosis. Copyright 2008 S. Karger AG, Basel.

  10. SLS Block 1-B and Exploration Upper Stage Navigation System Design

    Science.gov (United States)

    Oliver, T. Emerson; Park, Thomas B.; Smith, Austin; Anzalone, Evan; Bernard, Bill; Strickland, Dennis; Geohagan, Kevin; Green, Melissa; Leggett, Jarred

    2018-01-01

    The SLS Block 1B vehicle is planned to extend NASA's heavy lift capability beyond the initial SLS Block 1 vehicle. The most noticeable change for this vehicle from SLS Block 1 is the swapping of the upper stage from the Interim Cryogenic Propulsion stage (ICPS), a modified Delta IV upper stage, to the more capable Exploration Upper Stage (EUS). As the vehicle evolves to provide greater lift capability and execute more demanding missions so must the SLS Integrated Navigation System to support those missions. The SLS Block 1 vehicle carries two independent navigation systems. The responsibility of the two systems is delineated between ascent and upper stage flight. The Block 1 navigation system is responsible for the phase of flight between the launch pad and insertion into Low-Earth Orbit (LEO). The upper stage system assumes the mission from LEO to payload separation. For the Block 1B vehicle, the two functions are combined into a single system intended to navigate from ground to payload insertion. Both are responsible for self-disposal once payload delivery is achieved. The evolution of the navigation hardware and algorithms from an inertial-only navigation system for Block 1 ascent flight to a tightly coupled GPS-aided inertial navigation system for Block 1-B is described. The Block 1 GN&C system has been designed to meet a LEO insertion target with a specified accuracy. The Block 1-B vehicle navigation system is designed to support the Block 1 LEO target accuracy as well as trans-lunar or trans-planetary injection accuracy. This is measured in terms of payload impact and stage disposal requirements. Additionally, the Block 1-B vehicle is designed to support human exploration and thus is designed to minimize the probability of Loss of Crew (LOC) through high-quality inertial instruments and Fault Detection, Isolation, and Recovery (FDIR) logic. The preliminary Block 1B integrated navigation system design is presented along with the challenges associated with

  11. Reliability in the Power System Modeled in a Multi- Stage Stochastic Mixed Integer Programming Model

    DEFF Research Database (Denmark)

    Simonsen Nielsen, Michael Pascal

    Contributions from this article are that it takes the characteristics of the power system into account at different stages, which gives a more realistic presentation of the welfare aspects to be gained by an optimal operation/ dispatch of the power system. This article is utilizing a Multi......-Stage Stochastic Mixed Integer Programming Model that handles uncertainty in a flexible and practical way. The method applied relies on state-of-the-art modeling within this field, but the method applied in this article is extended by using decomposition....

  12. Droop Control with Improved Disturbance Adaption for PV System with Two Power Conversion Stages

    DEFF Research Database (Denmark)

    Liu, Hongpeng; Loh, Poh Chiang; Wang, Xiongfei

    2016-01-01

    issues, an improved droop scheme for a two-stage PV system has been developed in the paper. The developed scheme uses the same control structure in both grid-connected and islanded modes, which together with properly tuned synchronizers, allows mode transfer to be seamlessly triggered. Moreover...... with no or insufficient storage for cushioning climatic changes. In addition, most droop-controlled literatures have assumed a single dc-ac inverter with its input dc source fixed. Front-end dc-dc converter added to a two-stage photovoltaic (PV) system has therefore usually been ignored. To address these unresolved...

  13. The Effect of Effluent Recirculation in a Semi-Continuous Two-Stage Anaerobic Digestion System

    OpenAIRE

    Solmaz Aslanzadeh; Karthik Rajendran; Azam Jeihanipour; Mohammad J. Taherzadeh

    2013-01-01

    The effect of recirculation in increasing organic loading rate (OLR) and decreasing hydraulic retention time (HRT) in a semi-continuous two-stage anaerobic digestion system using stirred tank reactor (CSTR) and an upflow anaerobic sludge bed (UASB) was evaluated. Two-parallel processes were in operation for 100 days, one with recirculation (closed system) and the other without recirculation (open system). For this purpose, two structurally different carbohydrate-based substrates were used; st...

  14. Edmonton obesity staging system among pediatric patients: a validation and obesogenic risk factor analysis.

    Science.gov (United States)

    Grammatikopoulou, M G; Chourdakis, M; Gkiouras, K; Roumeli, P; Poulimeneas, D; Apostolidou, E; Chountalas, I; Tirodimos, I; Filippou, O; Papadakou-Lagogianni, S; Dardavessis, T

    2018-01-08

    The Edmonton Obesity Staging System for Pediatrics (EOSS-P) is a useful tool, delineating different obesity severity tiers associated with distinct treatment barriers. The aim of the study was to apply the EOSS-P on a Greek pediatric cohort and assess risk factors associated with each stage, compared to normal weight controls. A total of 361 children (2-14 years old), outpatients of an Athenian hospital, participated in this case-control study by forming two groups: the obese (n = 203) and the normoweight controls (n = 158). Anthropometry, blood pressure, blood and biochemical markers, comorbidities and obesogenic lifestyle parameters were recorded and the EOSS-P was applied. Validation of EOSS-P stages was conducted by juxtaposing them with IOTF-defined weight status. Obesogenic risk factors' analysis was conducted by constructing gender-and-age-adjusted (GA) and multivariate logistic models. The majority of obese children were stratified at stage 1 (46.0%), 17.0% were on stage 0, and 37.0% on stage 2. The validation analysis revealed that EOSS-P stages greater than 0 were associated with diastolic blood pressure and levels of glucose, cholesterol, LDL and ALT. Reduced obesity odds were observed among children playing outdoors and increased odds for every screen time hour, both in the GA and in the multivariate analyses (all P  2 times/week was associated with reduced obesity odds in the GA analysis (OR = 0.57, 95% CI = 0.33-0.98, P linear = 0.047), it lost its significance in the multivariate analysis (P linear = 0.145). Analogous results were recorded in the analyses of the abovementioned physical activity risk factors for the EOSS-P stages. Linear relationships were observed for fast-food consumption and IOTF-defined obesity and higher than 0 EOSS-P stages. Parental obesity status was associated with all EOSS-P stages and IOTF-defined obesity status. Few outpatients were healthy obese (stage 0), while the majority exhibited several comorbidities

  15. Continuous removal of endocrine disruptors by versatile peroxidase using a two-stage system.

    Science.gov (United States)

    Taboada-Puig, Roberto; Lu-Chau, Thelmo A; Eibes, Gemma; Feijoo, Gumersindo; Moreira, Maria T; Lema, Juan M

    2015-01-01

    The oxidant Mn(3+) -malonate, generated by the ligninolytic enzyme versatile peroxidase in a two-stage system, was used for the continuous removal of endocrine disrupting compounds (EDCs) from synthetic and real wastewaters. One plasticizer (bisphenol-A), one bactericide (triclosan) and three estrogenic compounds (estrone, 17β-estradiol, and 17α-ethinylestradiol) were removed from wastewater at degradation rates in the range of 28-58 µg/L·min, with low enzyme inactivation. First, the optimization of three main parameters affecting the generation of Mn(3+) -malonate (hydraulic retention time as well as Na-malonate and H2 O2 feeding rates) was conducted following a response surface methodology (RSM). Under optimal conditions, the degradation of the EDCs was proven at high (1.3-8.8 mg/L) and environmental (1.2-6.1 µg/L) concentrations. Finally, when the two-stage system was compared with a conventional enzymatic membrane reactor (EMR) using the same enzyme, a 14-fold increase of the removal efficiency was observed. At the same time, operational problems found during EDCs removal in the EMR system (e.g., clogging of the membrane and enzyme inactivation) were avoided by physically separating the stages of complex formation and pollutant oxidation, allowing the system to be operated for a longer period (∼8 h). This study demonstrates the feasibility of the two-stage enzymatic system for removing EDCs both at high and environmental concentrations. © 2015 American Institute of Chemical Engineers.

  16. Liver-inherent immune system: its role in blood-stage malaria.

    Science.gov (United States)

    Wunderlich, Frank; Al-Quraishy, Saleh; Dkhil, Mohamed A

    2014-01-01

    The liver is well known as that organ which is obligately required for the intrahepatocyte development of the pre-erythrocytic stages of the malaria-causative agent Plasmodium. However, largely neglected is the fact that the liver is also a central player of the host defense against the morbidity- and mortality-causing blood stages of the malaria parasites. Indeed, the liver is equipped with a unique immune system that acts locally, however, with systemic impact. Its main "antipodal" functions are to recognize and to generate effective immunoreactivity against pathogens on the one hand, and to generate tolerance to avoid immunoreactivity with "self" and harmless substances as dietary compounds on the other hand. This review provides an introductory survey of the liver-inherent immune system: its pathogen recognition receptors including Toll-like receptors (TLRs) and its major cell constituents with their different facilities to fight and eliminate pathogens. Then, evidence is presented that the liver is also an essential organ to overcome blood-stage malaria. Finally, we discuss effector responses of the liver-inherent immune system directed against blood-stage malaria: activation of TLRs, acute phase response, phagocytic activity, cytokine-mediated pro- and anti-inflammatory responses, generation of "protective" autoimmunity by extrathymic T cells and B-1 cells, and T cell-mediated repair of liver injuries mainly produced by malaria-induced overreactions of the liver-inherent immune system.

  17. Target tracking system based on preliminary and precise two-stage compound cameras

    Science.gov (United States)

    Shen, Yiyan; Hu, Ruolan; She, Jun; Luo, Yiming; Zhou, Jie

    2018-02-01

    Early detection of goals and high-precision of target tracking is two important performance indicators which need to be balanced in actual target search tracking system. This paper proposed a target tracking system with preliminary and precise two - stage compound. This system using a large field of view to achieve the target search. After the target was searched and confirmed, switch into a small field of view for two field of view target tracking. In this system, an appropriate filed switching strategy is the key to achieve tracking. At the same time, two groups PID parameters are add into the system to reduce tracking error. This combination way with preliminary and precise two-stage compound can extend the scope of the target and improve the target tracking accuracy and this method has practical value.

  18. Expression, purification and characterization of the cancer-germline antigen GAGE12I: a candidate for cancer immunotherapy

    DEFF Research Database (Denmark)

    Gjerstorff, Morten F; Besir, Hüseyin; Larsen, Martin R

    2010-01-01

    for immunotherapy and candidates for cancer vaccines. Recombinant proteins may be superior to peptides as immunogens, since they have the potential to prime both CD4(+) and CD8(+) T cells and are not dependent on patient HLA-type. We have developed a method for production of highly pure recombinant GAGE12I......GAGE cancer-germline antigens are frequently expressed in a broad range of different cancers, while their expression in normal tissues is limited to the germ cells of the immune privileged organs, testis and ovary. GAGE proteins are immunogenic in humans, which make them promising targets...... filtration and formaldehyde cross-linking indicated that GAGE12I forms tetramers. The purified recombinant GAGE12I represents a candidate molecule for vaccination of cancer patients and will form the basis for further structural analysis of GAGE proteins....

  19. Maglev six degree-of-freedom fine position stage control system

    Energy Technology Data Exchange (ETDEWEB)

    Wronosky, J.B.; Smith, T.G.; Darnold, J.R.; Jordan, J.D.

    1995-12-31

    A wafer positioning system was recently developed by Sandia National Laboratories for an Extreme Ultraviolet Lithography (EUVL). The system, which utilizes a magnetically levitated fine stage to provide ultra-precise positioning in all six degrees of freedom, incorporates technological improvements resulting from four years of prototype development experience. System enhancements, implemented on a second generation design for a National Center for Advanced Information Component Manufacturing (NCAICM) Structural Control Testbed, define the present level of research. This paper describes the design, implementation, and functional capability of the systems. Specifics regarding control system electronics, including software and control algorithm structure, as well as performance design goals and test results are presented.

  20. An Investigation On The Blasting Strain Fields Between The Adjacent Bopeholes With Dynamic Moire-Photoelasticity And Strain Gages

    Science.gov (United States)

    Zhenhai, Zhu; Yanjun, Sun

    1987-01-01

    The blasting strain fields between the adjacent boreholes initiated simultaneously were investigated with the dynamic moire-photoelasticity and the strain gages. A multiple spark dynamic photoelastic apparatus (Mode WZDD-1) and the super-dynamic. measuring system were utilized in the dynamic recording. According to the dynamic moire-photoelastic fringe patterns, the superposition of blasting stress waves was analysed, and the distribution of az(in the direction of the line linking two adjacent borehole centers, which is simply called linking-center line in the following) and ar (in the direction which is normal to the linking-center line) in the linking-center line and ea. in the line which is vertical to the linking-center line through the middel point of the linking-center line were calculated quantitatively. The oscillations of strain vs. time in the linking-center line due to the superposition of blasting stress waves were recorded with the foil strain gages. The laws of superposition and attenuation of stress waves between boreholes derived from the measured and calculated results are in agreement with the results from the theoretical analyses.

  1. ABC transporters and xenobiotic defense systems in early life stages of rainbow trout (Oncorhynchus mykiss).

    Science.gov (United States)

    Kropf, Christian; Segner, Helmut; Fent, Karl

    2016-01-01

    Embryos of oviparous fish, in contrast to (ovo) viviparous species, develop in the aquatic environment, and therefore need solute transport systems at their body surfaces for maintaining internal homeostasis and defending against potentially harmful substances. We hypothesized that solute transporters undergo changes in tissue distribution from the embryo to the larval stage. We therefore studied the mRNA profiles of eight ABC transporters (abcb1a, abcb1b, abcc1, abcc2, abcc3, abcc4, abcc5, abcg2) and three solute carriers (oatp1d, putative oatp2 putative, mate1) in different body regions (head, yolk sac epithelium, abdominal viscera, skin/muscles) of developing rainbow trout. Additionally, we investigated mRNA levels of phase I (cyp1a, cyp3a) and phase II (gstp, putative ugt1, putative ugt2) biotransformation enzymes. The study covered the developmental period from the eleuthero-embryo stage to the first-feeding larval stage (1-20days post-hatch, dph). At 1dph, transcripts of abcc2, abcc4, abcg2, cyp3a, gstp, putative mate1, and putative oatp2 occurred primarily in the yolk sac epithelium, whereas at later stages expression of these genes was predominantly observed in the abdominal viscera. The functional activity of ABC transporters in fish early life stages was assessed by rhodamine B accumulation assays. Finally, we investigated the potential impact of xenobiotics (clotrimazole, clofibric acid) on the ABC and biotransformation systems of trout early life stages. While clofibric acid had no effect, clotrimazole lead to an increased rhodamine B accumulation. The results provide evidence that the transition from the eleuthero-embryo to the larval stage is accompanied by a major alteration in tissue expression of ABC transporters. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. New J-STAGE system accelerates digitization and distribution of academic journals from Japan

    Science.gov (United States)

    Sato, Ryuichi; Kubota, Soichi; Aoyama, Kota; Tsuchiya, Eri; Miyagawa, Yoshiyuki

    13 years have passed since J-STAGE was launched. At present no one could deny that its user interface and functions were already out of date comparing to foreign established e-journals. So JST has developed a new system called “J-STAGE3” in order to offer better usability and give powerful dissemination of academic papers from Japan. As the result of it, they will be able to enjoy the following things: 1) integration of two databases, Journal@rchive and J-STAGE, 2) new design/interface, 3) introduction of international standard XML format, 4) advanced subscription management, 5) saving cost of publishers, and 6) improving J-STAGE online submission and review system. At the end of March 2011, we conducted a market research on current status of digitization on Japanese society journals. The report told us that digitization ratio of those was 62% in total but it was 34% in humanities/social sciences. Or it was 92% in English journals and 55% in Japanese ones. It means that we need further promotion of digitization. In this paper, we discuss functions and direction of J-STAGE3 as well as our role in promotion of digitization of Japanese society journals.

  3. Anaerobic sewage treatment in a one-stage UASB reactor and a combined UASB Digester system

    NARCIS (Netherlands)

    Mahmoud, N.A.; Zeeman, G.; Gijzen, H.J.; Lettinga, G.

    2004-01-01

    The treatment of sewage at 15°C was investigated in a one-stage upflow anaerobic sludge blanket (UASB) reactor and a UASB-Digester system. The latter consists of a UASB reactor complemented with a digester for mutual sewage treatment and sludge stabilisation. The UASB reactor was operated at a

  4. Three-stage enzymatic digestive system for a gut-on-a-chip

    NARCIS (Netherlands)

    de Haan, Pim; Ianovska, Margaryta A.; Mathwig, Klaus; Bouwmeester, Hans; Verpoorte, Elisabeth

    2017-01-01

    In this work, we present the development of a three-stage microfluidic system as a cell-free model for digestion in the human gastrointestinal (GI) tract. Larger-scale digestion models are currently being used for pharmacological, toxicological and nutritional studies to determine the possible

  5. Multi-stage fuzzy PID power system automatic generation controller in deregulated environments

    International Nuclear Information System (INIS)

    Shayeghi, H.; Shayanfar, H.A.; Jalili, A.

    2006-01-01

    In this paper, a multi-stage fuzzy proportional integral derivative (PID) type controller is proposed to solve the automatic generation control (AGC) problem in a deregulated power system that operates under deregulation based on the bilateral policy scheme. In each control area, the effects of the possible contracts are treated as a set of new input signals in a modified traditional dynamical model. The multi-stage controller uses the fuzzy switch to blend a proportional derivative (PD) fuzzy logic controller with an integral fuzzy logic input. The proposed controller operates on fuzzy values passing the consequence of a prior stage on to the next stage as fact. The salient advantage of this strategy is its high insensitivity to large load changes and disturbances in the presence of plant parameter variations and system nonlinearities. This newly developed strategy leads to a flexible controller with simple structure that is easy to implement, and therefore, it can be useful for the real world power systems. The proposed method is tested on a three area power system with different contracted scenarios under various operating conditions. The results of the proposed controller are compared with those of the classical fuzzy PID type controller and classical PID controller through some performance indices to illustrate its robust performance

  6. Evaluating Managerial Styles for System Development Life Cycle Stages to Ensure Software Project Success

    Science.gov (United States)

    Kocherla, Showry

    2012-01-01

    Information technology (IT) projects are considered successful if they are completed on time, within budget, and within scope. Even though, the required tools and methodologies are in place, IT projects continue to fail at a higher rate. Current literature lacks explanation for success within the stages of system development life-cycle (SDLC) such…

  7. Vibration isolation and dual-stage actuation pointing system for space precision payloads

    Science.gov (United States)

    Kong, Yongfang; Huang, Hai

    2018-02-01

    Pointing and stability requirements for future space missions are becoming more and more stringent. This work follows the pointing control method which consists of a traditional spacecraft attitude control system and a payload active pointing loop, further proposing a vibration isolation and dual-stage actuation pointing system for space precision payloads based on a soft Stewart platform. Central to the concept is using the dual-stage actuator instead of the traditional voice coil motor single-stage actuator to improve the payload active pointing capability. Based on a specified payload, the corresponding platform was designed to be installed between the spacecraft bus and the payload. The performance of the proposed system is demonstrated by preliminary closed-loop control investigations in simulations. With the ordinary spacecraft bus, the line-of-sight pointing accuracy can be controlled to below a few milliarcseconds in tip and tilt. Meanwhile, utilizing the voice coil motor with the softening spring in parallel, which is a portion of the dual-stage actuator, the system effectively achieves low-frequency motion transmission and high-frequency vibration isolation along the other four degree-of-freedom directions.

  8. DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection.

    Science.gov (United States)

    Gorna, Alina E; Bowater, Richard P; Dziadek, Jaroslaw

    2010-05-25

    Mycobacteria, including most of all MTB (Mycobacterium tuberculosis), cause pathogenic infections in humans and, during the infectious process, are exposed to a range of environmental insults, including the host's immune response. From the moment MTB is exhaled by infected individuals, through an active and latent phase in the body of the new host, until the time they reach the reactivation stage, MTB is exposed to many types of DNA-damaging agents. Like all cellular organisms, MTB has efficient DNA repair systems, and these are believed to play essential roles in mycobacterial pathogenesis. As different stages of infection have great variation in the conditions in which mycobacteria reside, it is possible that different repair systems are essential for progression to specific phases of infection. MTB possesses homologues of DNA repair systems that are found widely in other species of bacteria, such as nucleotide excision repair, base excision repair and repair by homologous recombination. MTB also possesses a system for non-homologous end-joining of DNA breaks, which appears to be widespread in prokaryotes, although its presence is sporadic within different species within a genus. However, MTB does not possess homologues of the typical mismatch repair system that is found in most bacteria. Recent studies have demonstrated that DNA repair genes are expressed differentially at each stage of infection. In the present review, we focus on different DNA repair systems from mycobacteria and identify questions that remain in our understanding of how these systems have an impact upon the infection processes of these important pathogens.

  9. New current control based MPPT technique for single stage grid connected PV systems

    International Nuclear Information System (INIS)

    Jain, Sachin; Agarwal, Vivek

    2007-01-01

    This paper presents a new maximum power point tracking algorithm based on current control for a single stage grid connected photovoltaic system. The main advantage of this algorithm comes from its ability to predict the approximate amplitude of the reference current waveform or power that can be derived from the PV array with the help of an intermediate variable β. A variable step size for the change in reference amplitude during initial tracking helps in fast tracking. It is observed that if the reference current amplitude is greater than the array capacity, the system gets unstable (i.e. moves into the positive slope region of the p-v characteristics of the array). The proposed algorithm prevents the PV system from entering the positive slope region of the p-v characteristics. It is also capable of restoring stability if the system goes unstable due to a sudden environmental change. The proposed algorithm has been tested on a new single stage grid connected PV configuration recently developed by the authors to feed sinusoidal current into the grid. The system is operated in a continuous conduction mode to realize advantages such as low device current stress, high efficiency and low EMI. A fast MPPT tracker with single stage inverter topology operating in CCM makes the overall system highly efficient. Specific cases of the system, operating in just discontinuous current mode and discontinuous current mode and their relative merits and demerits are also discussed

  10. System and method for single-phase, single-stage grid-interactive inverter

    Science.gov (United States)

    Liu, Liming; Li, Hui

    2015-09-01

    The present invention provides for the integration of distributed renewable energy sources/storages utilizing a cascaded DC-AC inverter, thereby eliminating the need for a DC-DC converter. The ability to segment the energy sources and energy storages improves the maintenance capability and system reliability of the distributed generation system, as well as achieve wide range reactive power compensation. In the absence of a DC-DC converter, single stage energy conversion can be achieved to enhance energy conversion efficiency.

  11. Adaptive kanban control mechanism for a single-stage hybrid system

    Science.gov (United States)

    Korugan, Aybek; Gupta, Surendra M.

    2002-02-01

    In this paper, we consider a hybrid manufacturing system with two discrete production lines. Here the output of either production line can satisfy the demand for the same type of product without any penalties. The interarrival times for demand occurrences and service completions are exponentially distributed i.i.d. variables. In order to control this type of manufacturing system we suggest a single stage pull type control mechanism with adaptive kanbans and state independent routing of the production information.

  12. Multi-stage Fuzzy Power System Stabilizer Based on Modified Shuffled Frog Leaping Algorithm

    OpenAIRE

    Yousefi, Nasser

    2015-01-01

    This paper presents a new strategy based on Multi-stage Fuzzy (MSF) PID controller for damping Power System Stabilizer (PSS) in multi-machine environment using Modified Shuffled Frog Leaping (MSFL) algorithm. The proposed technique is a new meta-heuristic algorithm which is inspired by mating procedure of the honey bee. Actually, the mentioned algorithm is used recently in power systems which demonstrate the good reflex of this algorithm. Also, finding the parameters of PID controller in powe...

  13. Evaluating the Various Cropping Systems on Cd Concentrations of Different Growth Stages of Wheat

    Directory of Open Access Journals (Sweden)

    Khoshnaz Payandeh

    2017-12-01

    Full Text Available Soil contamination with heavy metals would accumulate these elements in plant tissues and decrease qualitaty and quantity of agricultural producs and thus endanger human and animal healths. Previous crop residues and rates of fertilizers applications (especially phosphorus fertilizer are the most important effective factors on accumulation of cadmium in crop tissues. Another influential factor affecting soil shrinkage is crop rotation which induces the solubility of cadmium. This research was aimed to assess the effects of conventional cropping system on cadmium concentrations in wheat at its different growth stages by using a split plot in time experiment based on completely randomized block design with three replications in the 2014-2015 growing season in Shavoor Agricultural Research Station (Khuzestan province. Main plot consisted of cropping system (rice-wheat, fallow-wheat and sub plot of growth stages at three levels (tillering, flowering and ripening. Different wheat seed cadmium concentrations due to two cropping systems were different significantly at 1% probability level. Cadmium concentration in the seeds at rice-wheat cropping system (0.31 mg.kg-1 was higher than fallow-wheat system (0.27 mg.kg-1 which is higher than World Health Organization standards. Result of analysis of variance showed that the effect of cropping systems and different growth stages of wheat on root and stem cadmium concentrations were significant at 1% probability level. Rice-wheat cropping system resulted in higher cadmium concentration in root (1.09 mg.kg-1 and stem (0.73 mg.kg-1 compared to that of the fallow-wheat cropping system. Accumulation of cadmium in stem or root at different growth stages of wheat were not significant but it was totally additive, because range of variation of cadmium concentration from planting to harvest was low.

  14. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members

    DEFF Research Database (Denmark)

    Gjerstorff, M F; Ditzel, H J

    2008-01-01

    GAGE cancer/testis antigens are frequently expressed in many different types of cancer, whereas their expression in normal tissues is limited to the germ cells of the immune-privileged organs, testis and ovary. Thus, GAGE proteins may be attractive candidates for immunotherapy of cancer. This rev......GAGE cancer/testis antigens are frequently expressed in many different types of cancer, whereas their expression in normal tissues is limited to the germ cells of the immune-privileged organs, testis and ovary. Thus, GAGE proteins may be attractive candidates for immunotherapy of cancer...

  15. Simulink Model of the Ares I Upper Stage Main Propulsion System

    Science.gov (United States)

    Burchett, Bradley T.

    2008-01-01

    A numerical model of the Ares I upper stage main propulsion system is formulated based on first principles. Equation's are written as non-linear ordinary differential equations. The GASP fortran code is used to compute thermophysical properties of the working fluids. Complicated algebraic constraints are numerically solved. The model is implemented in Simulink and provides a rudimentary simulation of the time history of important pressures and temperatures during re-pressurization, boost and upper stage firing. The model is validated against an existing reliable code, and typical results are shown.

  16. Waterhammer Modeling for the Ares I Upper Stage Reaction Control System Cold Flow Development Test Article

    Science.gov (United States)

    Williams, Jonathan H.

    2010-01-01

    The Upper Stage Reaction Control System provides three-axis attitude control for the Ares I launch vehicle during active Upper Stage flight. The system design must accommodate rapid thruster firing to maintain the proper launch trajectory and thus allow for the possibility to pulse multiple thrusters simultaneously. Rapid thruster valve closure creates an increase in static pressure, known as waterhammer, which propagates throughout the propellant system at pressures exceeding nominal design values. A series of development tests conducted in the fall of 2009 at Marshall Space Flight Center were performed using a water-flow test article to better understand fluid performance characteristics of the Upper Stage Reaction Control System. A subset of the tests examined waterhammer along with the subsequent pressure and frequency response in the flight-representative system and provided data to anchor numerical models. This thesis presents a comparison of waterhammer test results with numerical model and analytical results. An overview of the flight system, test article, modeling and analysis are also provided.

  17. Scout fourth stage attitude and velocity control (AVC) system feasibility study

    Science.gov (United States)

    Byars, L. B.

    1975-01-01

    The feasibility of incorporating a guidance system in the Scout fourth stage to achieve a significant improvement in expected payload delivery accuracy is studied. The technical investigations included the determination of the AVC equipment performance requirements, establishment of qualification and acceptance test levels, generation of layouts illustrating design approaches for the upper D and payload transition sections to incorporate the hardware, and the preparation of a vendor bid package. Correction concepts, utilizing inertial velocity and attitude, were identified and evaluated. Fourth stage attitude adjustments as determined from inertial velocity variation through the first three stages and a final velocity correction based upon the measured in-plane component errors at injection were employed. Results show radical reductions in apogee-perigee deviations.

  18. Design of an Image-Servo Mask Alignment System Using Dual CCDs with an XXY Stage

    Directory of Open Access Journals (Sweden)

    Chih-Jer Lin

    2016-02-01

    Full Text Available Mask alignment of photolithography technology is used in many applications, such as micro electro mechanical systems’ semiconductor process, printed circuits board, and flat panel display. As the dimensions of the product are getting smaller and smaller, the automatic mask alignment of photolithography is becoming more and more important. The traditional stacked XY-Θz stage is heavy and it has cumulative flatness errors due to its stacked assembly mechanism. The XXY stage has smaller cumulative error due to its coplanar design and it can move faster than the traditional XY-Θz stage. However, the relationship between the XXY stage’s movement and the commands of the three motors is difficult to compute, because the movements of the three motors on the same plane are coupling. Therefore, an artificial neural network is studied to establish a nonlinear mapping from the desired position and orientation of the stage to three motors’ commands. Further, this paper proposes an image-servo automatic mask alignment system, which consists of a coplanar XXY stage, dual GIGA-E CCDs with lens and a programmable automatic controller (PAC. Before preforming the compensation, a self-developed visual-servo provides the positioning information which is obtained from the image processing and pattern recognition according to the specified fiducial marks. To obtain better precision, two methods including the center of gravity method and the generalize Hough Transformation are studied to correct the shift positioning error.

  19. Grid Integration of Single Stage Solar PV System using Three-level Voltage Source Converter

    Science.gov (United States)

    Hussain, Ikhlaq; Kandpal, Maulik; Singh, Bhim

    2016-08-01

    This paper presents a single stage solar PV (photovoltaic) grid integrated power generating system using a three level voltage source converter (VSC) operating at low switching frequency of 900 Hz with robust synchronizing phase locked loop (RS-PLL) based control algorithm. To track the maximum power from solar PV array, an incremental conductance algorithm is used and this maximum power is fed to the grid via three-level VSC. The use of single stage system with three level VSC offers the advantage of low switching losses and the operation at high voltages and high power which results in enhancement of power quality in the proposed system. Simulated results validate the design and control algorithm under steady state and dynamic conditions.

  20. Method for simulating predictive control of building systems operation in the early stages of building design

    DEFF Research Database (Denmark)

    Petersen, Steffen; Svendsen, Svend

    2011-01-01

    A method for simulating predictive control of building systems operation in the early stages of building design is presented. The method uses building simulation based on weather forecasts to predict whether there is a future heating or cooling requirement. This information enables the thermal...... control systems of the building to respond proactively to keep the operational temperature within the thermal comfort range with the minimum use of energy. The method is implemented in an existing building simulation tool designed to inform decisions in the early stages of building design through...... parametric analysis. This enables building designers to predict the performance of the method and include it as a part of the solution space. The method furthermore facilitates the task of configuring appropriate building systems control schemes in the tool, and it eliminates time consuming manual...

  1. Two-stage commercial evaluation of engineering systems production projects for high-rise buildings

    Science.gov (United States)

    Bril, Aleksander; Kalinina, Olga; Levina, Anastasia

    2018-03-01

    The paper is devoted to the current and debatable problem of methodology of choosing the effective innovative enterprises for venture financing. A two-stage system of commercial innovation evaluation based on the UNIDO methodology is proposed. Engineering systems account for 25 to 40% of the cost of high-rise residential buildings. This proportion increases with the use of new construction technologies. Analysis of the construction market in Russia showed that the production of internal engineering systems elements based on innovative technologies has a growth trend. The production of simple elements is organized in small enterprises on the basis of new technologies. The most attractive for development is the use of venture financing of small innovative business. To improve the efficiency of these operations, the paper proposes a methodology for a two-stage evaluation of small business development projects. A two-stage system of commercial evaluation of innovative projects allows creating an information base for informed and coordinated decision-making on venture financing of enterprises that produce engineering systems elements for the construction business.

  2. Characteristics of multi-stage AGMD-DCMD cascade system for oxygen isotope production

    International Nuclear Information System (INIS)

    Kim, Jae Woo; Choi, Hwa Rim; Chang, Dae Sik; Kim, Taek Soo; Lim, Gwon; Jeong, Do Young

    2005-01-01

    Membrane distillation (MD) appears to be useful for the separation of the light isotopes such as oxygen and hydrogen isotopes contained in water, because membrane permeation units are compact and simple, and more importantly its energy consumption is low compared to conventional water fractional distillation.1-4 Permeation fluxes and the degree of oxygen isotope separation of AGMD (Air Gap Membrane Distillation) and VEMD (Vacuum Enhanced Membrane Distillation) processes were measured by using the hot water feed. Even though VEMD shows slightly higher isotopic separation degree with higher permeation flux, it is very difficult to apply VEMD to multi-stage cascade system. Since local oxygen isotope separation coefficient for a single membrane unit is low, multi-stage membrane cascade system is required to increase isotopic concentration further in product. Although AGMD is suitable for constructing the membrane cascading system, permeation flux for AGMD is still too low to apply to the isotope production system. In this investigation, we increased permeation flux of AGMD using AGMD-DCMD (Direct Contact Membrane Distillation) combined process. Permeation flux and degree of isotope separation of AGMD-DCMD combined process were measured by using 10 stages cascade system

  3. Two-stage commercial evaluation of engineering systems production projects for high-rise buildings

    Directory of Open Access Journals (Sweden)

    Bril Aleksander

    2018-01-01

    Full Text Available The paper is devoted to the current and debatable problem of methodology of choosing the effective innovative enterprises for venture financing. A two-stage system of commercial innovation evaluation based on the UNIDO methodology is proposed. Engineering systems account for 25 to 40% of the cost of high-rise residential buildings. This proportion increases with the use of new construction technologies. Analysis of the construction market in Russia showed that the production of internal engineering systems elements based on innovative technologies has a growth trend. The production of simple elements is organized in small enterprises on the basis of new technologies. The most attractive for development is the use of venture financing of small innovative business. To improve the efficiency of these operations, the paper proposes a methodology for a two-stage evaluation of small business development projects. A two-stage system of commercial evaluation of innovative projects allows creating an information base for informed and coordinated decision-making on venture financing of enterprises that produce engineering systems elements for the construction business.

  4. Performance assessment and transient optimization of multi-stage solid desiccant air conditioning systems with building PV/T integration

    Science.gov (United States)

    Gadalla, Mohamed; Saghafifar, Mohammad

    2016-09-01

    One of the popular solar air conditioning technologies is desiccant air conditioning. Nonetheless, single stage desiccant air conditioning systems' coefficient of performance (COP) are relatively low. Therefore, multi-stage solid desiccant air conditioning systems are recommended. In this paper, an integrated double-stage desiccant air conditioning systems and PV/T collector is suggested for hot and humid climates such as the UAE. The results for the PV/T implementation in the double-stage desiccant cooling system are assessed against the PV/T results for a single-stage desiccant air conditioning system. In order to provide a valid comparative evaluation between the single and double stage desiccant air conditioning systems, an identical PV/T module, in terms of dimensions, is incorporated into these systems. The overall required auxiliary air heating is abated by 46.0% from 386.8 MWh to 209.0 MWh by replacing the single stage desiccant air conditioning system with the proposed double stage configuration during June to October. Moreover, the overall averaged solar share during the investigated months for the single and double stage systems are 36.5% and 43.3%.

  5. A Conversion of Wheatstone Bridge to Current-Loop Signal Conditioning for Strain Gages

    Science.gov (United States)

    Anderson, Karl F.

    1995-01-01

    Current loop circuitry replaced Wheatstone bridge circuitry to signal-condition strain gage transducers in more than 350 data channels for two different test programs at NASA Dryden Flight Research Center. The uncorrected test data from current loop circuitry had a lower noise level than data from comparable Wheatstone bridge circuitry, were linear with respect to gage-resistance change, and were uninfluenced by varying lead-wire resistance. The current loop channels were easier for the technicians to set up, verify, and operate than equivalent Wheatstone bridge channels. Design choices and circuit details are presented in this paper in addition to operational experience.

  6. Materials, Processes and Manufacturing in Ares 1 Upper Stage: Integration with Systems Design and Development

    Science.gov (United States)

    Bhat, Biliyar N.

    2008-01-01

    Ares I Crew Launch Vehicle Upper Stage is designed and developed based on sound systems engineering principles. Systems Engineering starts with Concept of Operations and Mission requirements, which in turn determine the launch system architecture and its performance requirements. The Ares I-Upper Stage is designed and developed to meet these requirements. Designers depend on the support from materials, processes and manufacturing during the design, development and verification of subsystems and components. The requirements relative to reliability, safety, operability and availability are also dependent on materials availability, characterization, process maturation and vendor support. This paper discusses the roles and responsibilities of materials and manufacturing engineering during the various phases of Ares IUS development, including design and analysis, hardware development, test and verification. Emphasis is placed how materials, processes and manufacturing support is integrated over the Upper Stage Project, both horizontally and vertically. In addition, the paper describes the approach used to ensure compliance with materials, processes, and manufacturing requirements during the project cycle, with focus on hardware systems design and development.

  7. Evolution of International Space Station GN&C System Across ISS Assembly Stages

    Science.gov (United States)

    Lee, Roscoe; Frank, K. D. (Technical Monitor)

    1999-01-01

    The Guidance Navigation and Control (GN&C) system for the International Space Station is initially implemented by the Functional Cargo Block (FGB) which was built by the Khrunichev Space Center under direct contract to Boeing. This element (Stage 1A/R) was launched on 20 November 1998 and is currently operating on-orbit. The components and capabilities of the FGB Motion Control System (MCS) are described. The next ISS element, which has GN&C functionality will be the Service Module (SM) built by Rocket Space Corporation-Energia. This module is scheduled for launch (Stage 1R) in early 2000. Following activation of the SM GN&C system, the FGB MCS is deactivated and no longer used. The components and capabilities of the SM GN&C system are described. When a Progress vehicle is attached to the ISS it can be used for reboost operations, based on commands provided by the Mission Control Center-Moscow. When a data connection is implemented between the SM and the Progress, the SM can command the Progress thrusters for attitude control and reboosts. On Stage 5A, the U.S. GN&C system will become activated when the U.S. Laboratory is de loyed and installed (launch schedule is currently TBD). The U.S. GN&C system provides non-propulsive control capabilities to support micro-gravity operations and minimize the use of propellant for attitude control, and an independent capability for determining the ISS state vector, attitude, attitude rate. and time.. The components and capabilities of the U.S. GN&C system are described and the interactions between the U.S. and Russian Segment GN&C systems are also described.

  8. Performance evaluation of a piezoactuator-based single-stage valve system subjected to high temperature

    International Nuclear Information System (INIS)

    Jeon, Juncheol; Han, Chulhee; Ung Chung, Jye; Choi, Seung-Bok

    2015-01-01

    In this paper, a novel single-stage valve system activated by a piezostack actuator is proposed and experimentally evaluated at both room temperature (20 °C) and high temperature (100 °C) conditions. A hinge-lever displacement amplifier is adopted in the valve system to magnify the displacement generated from the piezostack actuator. After explaining the operating principle of the proposed piezostack-driven single-stage valve system, the geometric dimensions and mechanical properties of the valve components are discussed in details. An experimental apparatus is then manufactured to evaluate the performances of the valve system such as flow rate. The experimental apparatus consists of a heat chamber, which can regulate the temperature of the valve system and oil, pneumatic-hydraulic cylinders, a hydraulic circuit, a pneumatic circuit, electronic devices, an interface card, and a high voltage amplifier. The pneumatic-hydraulic cylinder transforms the pneumatic pressure into hydraulic pressure. The performances of the valve system regarding spool response, pressure drop, and flow rate are evaluated and presented. In addition, the performance of the valve system under high temperature condition is compared with that under room temperature condition. The experimental results are plotted in both frequency and time domains. (paper)

  9. Advanced optical design and control of multi-colored SSL system for stage lighting application

    DEFF Research Database (Denmark)

    Chakrabarti, Maumita

    mixing system and provides a solution which is capable of replacing both the Fresnel lens spotlight Halogen lamp (2kW) and the commercially available LED luminaire (~160W), which have applications in stage lighting, theater lighting, TV studio lighting, etc. Since the optical design comprises LEDs...... homogeneity, which overcomes the expensive and tedious manual polishing or direct diamond turning. The tool fabrication provides an easy and inexpensive mold and hence a cost effective injection molding replication process....

  10. Two-stage SQUID system and transducers development for MiniGrail

    NARCIS (Netherlands)

    Gottardi, L.; Podt, M.; Flokstra, Jakob; Bassan, M.; Karbalai-Sadegh, A.; Minenkov, Y.; Reinke, W.; Shumack, A.; Srinivas, S.; de Waard, A.; de Waard, A.; Frossati, G.

    2004-01-01

    We present measurements on a two-stage SQUID system based on a dc-SQUID as a sensor and a DROS as an amplifier. We measured the intrinsic noise of the dc-SQUID at 4.2 K. A new dc-SQUID has been fabricated. It was specially designed to be used with MiniGRAIL transducers. Cooling fins have been added

  11. Improved Duct Systems Task Report with StageGate 2 Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Moyer, Neil [Florida Solar Energy Center, Cocoa, FL (United States); Stroer, Dennis [Calcs-Plus, Venice, FL (United States)

    2007-12-31

    This report is about Building America Industrialized Housing Partnership's work with two industry partners, Davalier Homes and Southern Energy Homes, in constructing and evaluating prototype interior duct systems. Issues of energy performance, comfort, DAPIA approval, manufacturability and cost is addressed. A stage gate 2 analysis addresses the current status of project showing that there are still refinements needed to the process of incorporating all of the ducts within the air and thermal boundaries of the envelope.

  12. A predator-prey system with stage-structure for predator and nonlocal delay

    DEFF Research Database (Denmark)

    Lin, Z.G.; Pedersen, Michael; Zhang, Lai

    2010-01-01

    This paper deals with the behavior of solutions to the reaction-diffusion system under homogeneous Neumann boundary condition, which describes a prey-predator model with nonlocal delay. Sufficient conditions for the global stability of each equilibrium are derived by the Lyapunov functional...... and the results show that the introduction of stage-structure into predator positively affects the coexistence of prey and predator. Numerical simulations are performed to illustrate the results....

  13. A technique of building a value function at the stage of conceptual design of microprocessor systems

    Directory of Open Access Journals (Sweden)

    B. N. Chugaev

    2017-01-01

    Full Text Available The aim of this study is to formalize the selection of optimal technical solutions early in the design of microprocessor-based systems, which allows developers to analyze the recommended solutions, and has, in comparison with the traditional «intuitive» approach, at least two undeniable merits. First, the accepted assumptions and limitations are clearly formed. Secondly, it is defined precisely, in what sense the decision is optimal. When designing microprocessor systems (systems hereafter, several characteristics have to be taken into account at the same time. In general, when n properties are taken into account for each of the compared systems, then the solution of the task of choosing “the best” system depends on choosing a function-criterion. Such function is called a value function in the article. A simple quadratic function is suggested as the value function, it can be interpreted as the distance in Euclidean space of systems technical data. The system, which corresponds to the point nearest to the point characterizing the master system with “limiting” characteristics, is considered the best one. This function approximates the designer’s system of preferences signifi cantly better than a “classical” linear value function. In conclusion, note that the developed recommendations allow the designer of complex technical systems to analyze the proposed solutions in the early stages of design and, in case of disagreement with them, to indicate the reasons why he considers them inadequate. The designed machine optimization of technical solutions in conjunction with the traditional engineering approach should allow more reasonable choosing the structure of systems at the stage of systems conceptual design.

  14. Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation

    DEFF Research Database (Denmark)

    Gjerstorff, Morten; Harkness, Linda; Kassem, Moustapha

    2008-01-01

    of the ectodermal ring and apical epidermal ridge. Neuroectodermal cells in the floor plate and adjacent processes and endfeet of radial glial cells also expressed GAGE. In addition, GAGE family members were expressed in the peripheral adrenal cortex of 6-9-week-old embryos and fetuses, which specifically...

  15. Evaluation of Revised International Staging System (R-ISS) for transplant-eligible multiple myeloma patients.

    Science.gov (United States)

    González-Calle, Verónica; Slack, Abigail; Keane, Niamh; Luft, Susan; Pearce, Kathryn E; Ketterling, Rhett P; Jain, Tania; Chirackal, Sintosebastian; Reeder, Craig; Mikhael, Joseph; Noel, Pierre; Mayo, Angela; Adams, Roberta H; Ahmann, Gregory; Braggio, Esteban; Stewart, A Keith; Bergsagel, P Leif; Van Wier, Scott A; Fonseca, Rafael

    2018-04-06

    The International Myeloma Working Group has proposed the Revised International Staging System (R-ISS) for risk stratification of multiple myeloma (MM) patients. There are a limited number of studies that have validated this risk model in the autologous stem cell transplant (ASCT) setting. In this retrospective study, we evaluated the applicability and value for predicting survival of the R-ISS model in 134 MM patients treated with new agents and ASCT at the Mayo Clinic in Arizona and the University Hospital of Salamanca in Spain. The patients were reclassified at diagnosis according to the R-ISS: 44 patients (33%) had stage I, 75 (56%) had stage II, and 15 (11%) had stage III. After a median follow-up of 60 months, R-ISS assessed at diagnosis was an independent predictor for overall survival (OS) after ASCT, with median OS not reached, 111 and 37 months for R-ISS I, II and III, respectively (P R-ISS II and having high-risk chromosomal abnormalities (CA) had a significant shorter median OS than those with R-ISS II without CA: 70 vs. 111 months, respectively. Therefore, this study lends further support for the R-ISS as a reliable prognostic tool for estimating survival in transplant myeloma patients and suggests the importance of high-risk CA in the R-ISS II group.

  16. Realization of single-phase single-stage grid-connected PV system

    Directory of Open Access Journals (Sweden)

    Osama M. Arafa

    2017-05-01

    Full Text Available This paper presents a single phase single stage grid-tied PV system. Grid angle detection is introduced to allow operation at any arbitrary power factor but unity power factor is chosen to utilize the full inverter capacity. The system ensures MPPT using the incremental conductance method and it can track the changes in insolation level without oscillations. A PI voltage controller and a dead-beat current controller are used to ensure high quality injected current to the grid. The paper investigates the system structure and performance through numerical simulation using Matlab/Simulink. An experimental setup controlled by the MicrolabBox DSP prototyping platform is utilized to realize the system and study its performance. The precautions for smooth and safe system operation including the startup sequence are fully considered in the implementation.

  17. Low cost optical tweezers systems using double coil driving stepping motor to controlling sample stage

    Science.gov (United States)

    Laowattanatham, N.; Cheamanunkul, N.; Plaipichit, S.; Buranasiri, P.; Nuansri, R.

    2013-06-01

    In this research, the low cost optical tweezers systems using X-Y stage has been developed by using 5-phase stepping motor. By using sequential double coil driving, we can obtain the driving torque larger than using the single coil driving. The moving scale is fine resolution at 0.2 micrometer. The overall systems based on microcontroller PIC18F458 and joystick controller with LabView® graphical user interface (GUI). The mechanical damping has been included in the system for decreasing the vibrational noise. By using this method, our optical tweezers system is cheaper than the other commercial system that has been used the piezoelectric driving, and still has the same efficiency.

  18. Plasma gasification of refuse derived fuel in a single-stage system using different gasifying agents.

    Science.gov (United States)

    Agon, N; Hrabovský, M; Chumak, O; Hlína, M; Kopecký, V; Masláni, A; Bosmans, A; Helsen, L; Skoblja, S; Van Oost, G; Vierendeels, J

    2016-01-01

    The renewable evolution in the energy industry and the depletion of natural resources are putting pressure on the waste industry to shift towards flexible treatment technologies with efficient materials and/or energy recovery. In this context, a thermochemical conversion method of recent interest is plasma gasification, which is capable of producing syngas from a wide variety of waste streams. The produced syngas can be valorized for both energetic (heat and/or electricity) and chemical (ammonia, hydrogen or liquid hydrocarbons) end-purposes. This paper evaluates the performance of experiments on a single-stage plasma gasification system for the treatment of refuse-derived fuel (RDF) from excavated waste. A comparative analysis of the syngas characteristics and process yields was done for seven cases with different types of gasifying agents (CO2+O2, H2O, CO2+H2O and O2+H2O). The syngas compositions were compared to the thermodynamic equilibrium compositions and the performance of the single-stage plasma gasification of RDF was compared to that of similar experiments with biomass and to the performance of a two-stage plasma gasification process with RDF. The temperature range of the experiment was from 1400 to 1600 K and for all cases, a medium calorific value syngas was produced with lower heating values up to 10.9 MJ/Nm(3), low levels of tar, high levels of CO and H2 and which composition was in good agreement to the equilibrium composition. The carbon conversion efficiency ranged from 80% to 100% and maximum cold gas efficiency and mechanical gasification efficiency of respectively 56% and 95%, were registered. Overall, the treatment of RDF proved to be less performant than that of biomass in the same system. Compared to a two-stage plasma gasification system, the produced syngas from the single-stage reactor showed more favourable characteristics, while the recovery of the solid residue as a vitrified slag is an advantage of the two-stage set-up. Copyright

  19. Space Transportation System Cargo projects: inertial stage/spacecraft integration plan. Volume 1: Management plan

    Science.gov (United States)

    1981-01-01

    The Kennedy Space Center (KSC) Management System for the Inertial Upper Stage (IUS) - spacecraft processing from KSC arrival through launch is described. The roles and responsibilities of the agencies and test team organizations involved in IUS-S/C processing at KSC for non-Department of Defense missions are described. Working relationships are defined with respect to documentation preparation, coordination and approval, schedule development and maintenance, test conduct and control, configuration management, quality control and safety. The policy regarding the use of spacecraft contractor test procedures, IUS contractor detailed operating procedures and KSC operations and maintenance instructions is defined. Review and approval requirements for each documentation system are described.

  20. Nuclear Technology. Course 27: Metrology. Module 27-2, Fixed Gages, Dividers, Calipers, and Micrometers.

    Science.gov (United States)

    Selleck, Ben; Espy, John

    This second in a series of eight modules for a course titled Metrology dscribes fixed gages, dividers, calipers, vernier and dial calipers, and micrometers. The module follows a typical format that includes the following sections: (l) introduction, (2) module prerequisites, (3) objectives, (4) notes to instructor/student, (5) subject matter, (6)…

  1. Iterative Strain-Gage Balance Calibration Data Analysis for Extended Independent Variable Sets

    Science.gov (United States)

    Ulbrich, Norbert Manfred

    2011-01-01

    A new method was developed that makes it possible to use an extended set of independent calibration variables for an iterative analysis of wind tunnel strain gage balance calibration data. The new method permits the application of the iterative analysis method whenever the total number of balance loads and other independent calibration variables is greater than the total number of measured strain gage outputs. Iteration equations used by the iterative analysis method have the limitation that the number of independent and dependent variables must match. The new method circumvents this limitation. It simply adds a missing dependent variable to the original data set by using an additional independent variable also as an additional dependent variable. Then, the desired solution of the regression analysis problem can be obtained that fits each gage output as a function of both the original and additional independent calibration variables. The final regression coefficients can be converted to data reduction matrix coefficients because the missing dependent variables were added to the data set without changing the regression analysis result for each gage output. Therefore, the new method still supports the application of the two load iteration equation choices that the iterative method traditionally uses for the prediction of balance loads during a wind tunnel test. An example is discussed in the paper that illustrates the application of the new method to a realistic simulation of temperature dependent calibration data set of a six component balance.

  2. Study on the behavior of resistance strain gages in nuclear radiation environments

    International Nuclear Information System (INIS)

    Kumagai, Katsuaki; Yokoo, Hiroshi; Kitahara, Tanemichi; Kaieda, Keisuke

    1975-08-01

    A series of irradiation experiments were carried out on the behavior of resistance strain gages in nuclear radiation environments. The gages made of bakelite base and advance (nickel-copper alloy) wire were bonded to stainless-steel or aluminium-alloy plates. They were inserted into an in-pile helium loop TLG-1 installed in the JRR-2 reactor, and irradiated at 80 0 C for nearly 300 hours, during which the apparent strain and the leakage current through the base material between the resistance wire and the plate were measured. The results are summarized in the following: (1) The sensitivity change and the insulation-resistance deterioration of the gage are hardly observed. (2) The apparent strain observed can be divided into two components; one dependent on the radiation intensity and the other on the radiation fluence. Both of them indicate the decrease of the gage resistance. (3) The former apparent strain is possibly due to the leakage current through the base material induced by gamma-rays. The latter may be ascribed to the decrease of the wire resistance caused by the radiation damage. (4) Either the half-bridge or full-bridge method makes it possible to compensate the apparent strain and to measure static strain for a few days satisfactorily as well as dynamic strain. (auth.)

  3. Staged cost optimization of urban storm drainage systems based on hydraulic performance in a changing environment

    Directory of Open Access Journals (Sweden)

    M. Maharjan

    2009-04-01

    Full Text Available Urban flooding causes large economic losses, property damage and loss of lives. The impact of environmental changes, mainly urbanization and climatic change, leads to increased runoff and peak flows which the drainage system must be able to cope with to reduce potential damage and inconvenience. Allowing for detention storage to compliment the conveyance capacity of the drainage system network is one of the approaches to reduce urban floods. Contemporary practice is to design systems against stationary environmental forcings – including design rainfall, landuse, etc. Due to the rapid change in the climate- and the urban environment, this approach is no longer appropriate, and explicit consideration of gradual changes during the life-time of the drainage system is warranted. In this paper, a staged cost optimization tool based on the hydraulic performance of the drainage system is presented. A one dimensional hydraulic model is used for hydraulic evaluation of the network together with a genetic algorithm based optimization tool to determine optimal intervention timings and responses over the analysis period. The model was applied in a case study area in the city of Porto Alegre, Brazil. It was concluded that considerable financial savings and/or additional level of flood-safety can be achieved by approaching the design problem as a staged plan rather than one-off scheme.

  4. Detection of Integrase Gene in E. coli Isolated from Pigs at Different Stages of Production System

    Directory of Open Access Journals (Sweden)

    Eulalia de la Torre

    2014-01-01

    Full Text Available Integrons are one of the genetic elements involved in the acquisition of antibiotic resistance. The aim of the present research is to investigate the presence of integrons in commensal Escherichia coli (E. coli strains, isolated from pigs at different stages of production system and from the environment in an Argentinian farm. Five sows postpartum and five randomly chosen piglets from each litter were sampled by rectal swabs. They were sampled again at day 21 and at day 70. Environmental samples from the farm were also obtained. E. coli containing any integron class or combination of both integrons was detected by polymerase chain reaction in 100% of sows and in piglets at different stages of production: farrowing pen stage 68.1%;, weaning 60%, and growing/finishing 85.8%, showing an increase along the production system. From environmental samples 78.4% of E. coli containing any integron class was detected. We conclude that animals and farm environment can act as reservoirs for potential spread of resistant bacteria by means of mobile genetic elements as integrons, which has a major impact on production of food animals and that can reach man through the food chain, constituting a problem for public health.

  5. Two-stage energy storage equalization system for lithium-ion battery pack

    Science.gov (United States)

    Chen, W.; Yang, Z. X.; Dong, G. Q.; Li, Y. B.; He, Q. Y.

    2017-11-01

    How to raise the efficiency of energy storage and maximize storage capacity is a core problem in current energy storage management. For that, two-stage energy storage equalization system which contains two-stage equalization topology and control strategy based on a symmetric multi-winding transformer and DC-DC (direct current-direct current) converter is proposed with bidirectional active equalization theory, in order to realize the objectives of consistent lithium-ion battery packs voltages and cells voltages inside packs by using a method of the Range. Modeling analysis demonstrates that the voltage dispersion of lithium-ion battery packs and cells inside packs can be kept within 2 percent during charging and discharging. Equalization time was 0.5 ms, which shortened equalization time of 33.3 percent compared with DC-DC converter. Therefore, the proposed two-stage lithium-ion battery equalization system can achieve maximum storage capacity between lithium-ion battery packs and cells inside packs, meanwhile efficiency of energy storage is significantly improved.

  6. Analyzing Effect of System Inertia on Grid Frequency Forecasting Usnig Two Stage Neuro-Fuzzy System

    Science.gov (United States)

    Chourey, Divyansh R.; Gupta, Himanshu; Kumar, Amit; Kumar, Jitesh; Kumar, Anand; Mishra, Anup

    2018-04-01

    Frequency forecasting is an important aspect of power system operation. The system frequency varies with load-generation imbalance. Frequency variation depends upon various parameters including system inertia. System inertia determines the rate of fall of frequency after the disturbance in the grid. Though, inertia of the system is not considered while forecasting the frequency of power system during planning and operation. This leads to significant errors in forecasting. In this paper, the effect of inertia on frequency forecasting is analysed for a particular grid system. In this paper, a parameter equivalent to system inertia is introduced. This parameter is used to forecast the frequency of a typical power grid for any instant of time. The system gives appreciable result with reduced error.

  7. Analyzing Effect of System Inertia on Grid Frequency Forecasting Usnig Two Stage Neuro-Fuzzy System

    Science.gov (United States)

    Chourey, Divyansh R.; Gupta, Himanshu; Kumar, Amit; Kumar, Jitesh; Kumar, Anand; Mishra, Anup

    2017-12-01

    Frequency forecasting is an important aspect of power system operation. The system frequency varies with load-generation imbalance. Frequency variation depends upon various parameters including system inertia. System inertia determines the rate of fall of frequency after the disturbance in the grid. Though, inertia of the system is not considered while forecasting the frequency of power system during planning and operation. This leads to significant errors in forecasting. In this paper, the effect of inertia on frequency forecasting is analysed for a particular grid system. In this paper, a parameter equivalent to system inertia is introduced. This parameter is used to forecast the frequency of a typical power grid for any instant of time. The system gives appreciable result with reduced error.

  8. A Two Stage Solution Procedure for Production Planning System with Advance Demand Information

    Science.gov (United States)

    Ueno, Nobuyuki; Kadomoto, Kiyotaka; Hasuike, Takashi; Okuhara, Koji

    We model for ‘Naiji System’ which is a unique corporation technique between a manufacturer and suppliers in Japan. We propose a two stage solution procedure for a production planning problem with advance demand information, which is called ‘Naiji’. Under demand uncertainty, this model is formulated as a nonlinear stochastic programming problem which minimizes the sum of production cost and inventory holding cost subject to a probabilistic constraint and some linear production constraints. By the convexity and the special structure of correlation matrix in the problem where inventory for different periods is not independent, we propose a solution procedure with two stages which are named Mass Customization Production Planning & Management System (MCPS) and Variable Mesh Neighborhood Search (VMNS) based on meta-heuristics. It is shown that the proposed solution procedure is available to get a near optimal solution efficiently and practical for making a good master production schedule in the suppliers.

  9. Alternatives generation and analysis for the Phase I intermediate waste feed staging system design requirements

    Energy Technology Data Exchange (ETDEWEB)

    Claghorn, R.D., Fluor Daniel Hanford

    1997-02-06

    This alternatives generation and analysis (AGA) addresses the question: What is the design basis for the facilities required to stage low-level waste (LLW) feed to the Phase I private contractors? Alternative designs for the intermediate waste feed staging system were developed, analyzed, and compared. Based on these analyses, this document recommends installing mixer pumps in the central pump pit of double-shell tanks 241-AP-102 and 241-AP-104. Also recommended is installing decant/transfer pumps at these tanks. These recommendations have clear advantages in that they provide a low shedule impact/risk and the highest operability of all the alternatives investigated. This revision incorporates comments from the decision board.

  10. A modified TNM staging system for non-metastatic colorectal cancer based on nomogram analysis of SEER database.

    Science.gov (United States)

    Kong, Xiangxing; Li, Jun; Cai, Yibo; Tian, Yu; Chi, Shengqiang; Tong, Danyang; Hu, Yeting; Yang, Qi; Li, Jingsong; Poston, Graeme; Yuan, Ying; Ding, Kefeng

    2018-01-08

    To revise the American Joint Committee on Cancer TNM staging system for colorectal cancer (CRC) based on a nomogram analysis of Surveillance, Epidemiology, and End Results (SEER) database, and to prove the rationality of enhancing T stage's weighting in our previously proposed T-plus staging system. Total 115,377 non-metastatic CRC patients from SEER were randomly grouped as training and testing set by ratio 1:1. The Nomo-staging system was established via three nomograms based on 1-year, 2-year and 3-year disease specific survival (DSS) Logistic regression analysis of the training set. The predictive value of Nomo-staging system for the testing set was evaluated by concordance index (c-index), likelihood ratio (L.R.) and Akaike information criteria (AIC) for 1-year, 2-year, 3-year overall survival (OS) and DSS. Kaplan-Meier survival curve was used to valuate discrimination and gradient monotonicity. And an external validation was performed on database from the Second Affiliated Hospital of Zhejiang University (SAHZU). Patients with T1-2 N1 and T1N2a were classified into stage II while T4 N0 patients were classified into stage III in Nomo-staging system. Kaplan-Meier survival curves of OS and DSS in testing set showed Nomo-staging system performed better in discrimination and gradient monotonicity, and the external validation in SAHZU database also showed distinctly better discrimination. The Nomo-staging system showed higher value in L.R. and c-index, and lower value in AIC when predicting OS and DSS in testing set. The Nomo-staging system showed better performance in prognosis prediction and the weight of lymph nodes status in prognosis prediction should be cautiously reconsidered.

  11. Expression of BAGE, GAGE, and MAGE genes in human gastric carcinoma.

    Science.gov (United States)

    Li, J; Yang, Y; Fujie, T; Baba, K; Ueo, H; Mori, M; Akiyoshi, T

    1996-09-01

    The MAGE, BAGE, and GAGE genes code for distinct antigens that are recognized by autologous cytolytic T lymphocytes. We investigated the expression of these genes in both cell lines and surgical samples of gastric carcinoma, using reverse transcription-PCR. Furthermore, the induction of these genes by 5-aza-2'-deoxycytidine (DAC), a demethylating agent, was also examined in several cell lines. Of 11 cell lines, BAGE, GAGE1-6, GAGE1-2, MAGE-1, and MAGE-3 were detected in 7 (64%), 4 (36%), 3 (27%), 8 (73%), and 8 (73%) cell lines, respectively. After the in vitro treatment of the negative cell lines with DAC, the expression of these genes became positive in 46 to 91% of these cell lines. No expression of these genes was seen in any of the 57 samples of normal gastric tissue. In contrast, the tumor tissue samples expressed BAGE, GAGE1-6, GAGE1-2, MAGE-1, and MAGE-3 in 13 (23%), 9 (16%), 6 (11%), 25 (44%), and 23 (40%) tissue samples, respectively. Thus, at least one of these genes was expressed in 35 (61%) of 57 carcinomas. An analysis of the relationship between clinicopathological factors and the expression of these genes revealed that either BAGE or one of these genes was more frequently expressed in histologically intestinal-type than in diffuse-type carcinomas. Our results suggest that, because of the higher expression of these genes and the possible induction of these genes by DAC, patients with gastric carcinoma may, therefore, be potential candidates for tumor-specific immunotherapy directed against these antigens.

  12. Novel design and sensitivity analysis of displacement measurement system utilizing knife edge diffraction for nanopositioning stages.

    Science.gov (United States)

    Lee, ChaBum; Lee, Sun-Kyu; Tarbutton, Joshua A

    2014-09-01

    This paper presents a novel design and sensitivity analysis of a knife edge-based optical displacement sensor that can be embedded with nanopositioning stages. The measurement system consists of a laser, two knife edge locations, two photodetectors, and axillary optics components in a simple configuration. The knife edge is installed on the stage parallel to its moving direction and two separated laser beams are incident on knife edges. While the stage is in motion, the direct transverse and diffracted light at each knife edge is superposed producing interference at the detector. The interference is measured with two photodetectors in a differential amplification configuration. The performance of the proposed sensor was mathematically modeled, and the effect of the optical and mechanical parameters, wavelength, beam diameter, distances from laser to knife edge to photodetector, and knife edge topography, on sensor outputs was investigated to obtain a novel analytical method to predict linearity and sensitivity. From the model, all parameters except for the beam diameter have a significant influence on measurement range and sensitivity of the proposed sensing system. To validate the model, two types of knife edges with different edge topography were used for the experiment. By utilizing a shorter wavelength, smaller sensor distance and higher edge quality increased measurement sensitivity can be obtained. The model was experimentally validated and the results showed a good agreement with the theoretically estimated results. This sensor is expected to be easily implemented into nanopositioning stage applications at a low cost and mathematical model introduced here can be used for design and performance estimation of the knife edge-based sensor as a tool.

  13. Implementation of Exhaust Gas Recirculation for Double Stage Waste Heat Recovery System on Large Container Vessel

    DEFF Research Database (Denmark)

    Andreasen, Morten; Marissal, Matthieu; Sørensen, Kim

    2014-01-01

    to reach the highest possible combination of pressure and temperature, and adapted to Tier III by introducing two alternative superheaters. The system design is optimized and found capable of producing from 400 to 1900 kW, with a weighted average power of 958 kW. The consumption profile is found...... of recovering some of the waste heat from the exhaust gas. This heat is converted into electrical energy used on-board instead of using auxiliary engines. Exhaust Gas Recirculation (EGR) systems, are recirculating a part of the exhaust gas through the engine combustion chamber to reduce emissions. WHRS combined...... with EGR is a potential way to improve system efficiency while reducing emissions. This paper investigates the feasibility of combining the two systems. EGR dilutes the fuel, lowering the combustion temperature and thereby the formation of NOx, to reach Tier III limitation. A double stage WHRS is set up...

  14. Predictive properties of different multidimensional staging systems in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Oga T

    2011-10-01

    Full Text Available Toru Oga1, Mitsuhiro Tsukino2, Takashi Hajiro3, Akihiko Ikeda4, Koichi Nishimura5 1Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 2Department of Respiratory Medicine, Hikone Municipal Hospital, Hikone, Japan; 3Department of Respiratory Medicine, Tenri Hospital, Tenri, Japan; 4Department of Respiratory Medicine, Nishi-Kobe Medical Center, Kobe, Japan; 5Department of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan Background: Chronic obstructive pulmonary disease (COPD is considered to be a respiratory disease with systemic manifestations. Some multidimensional staging systems, not based solely on the level of airflow limitation, have been developed; however, these systems have rarely been compared. Methods: We previously recruited 150 male outpatients with COPD for an analysis of factors related to mortality. For this report, we examined the discriminative and prognostic predictive properties of three COPD multidimensional measurements. These indices were the modified BODE (mBODE, which includes body mass index, airflow obstruction, dyspnea, and exercise capacity; the ADO, composed of age, dyspnea, and airflow obstruction; and the modified DOSE (mDOSE, comprising dyspnea, airflow obstruction, smoking status, and exacerbation frequency. Results: Among these indices, the frequency distribution of the mBODE index was the most widely and normally distributed. Univariate Cox proportional hazards analyses revealed that the scores on three indices were significantly predictive of 5-year mortality of COPD (P < 0.001. The scores on the mBODE and ADO indices were more significantly predictive of mortality than forced expiratory volume in 1 second, the Medical Research Council dyspnea score, and the St. George's Respiratory Questionnaire total score. However, peak oxygen uptake on progressive cycle ergometry was more significantly related to mortality than the scores on

  15. TNM staging system may be superior to Lugano and Ann Arbor systems in predicting the overall survival of patients with primary gastrointestinal lymphoma.

    Science.gov (United States)

    Chang, Shujian; Shi, Xin; Xu, Zhenyu; Liu, Quan

    2015-01-01

    To assess the survival predicting value of TNM, Lugano, and Ann Arbor staging systems in patients with primary gastrointestinal lymphoma (PGL). 101 patients with PGL were reviewed. All of them were staged according to TNM, Lugano, or Ann Arbor staging system. Five-year survival overall survival/OS rate was used as major clinical outcome. The prognostic value of different variables like depth of tumor infiltration (T), lymph node status (N), metastasis (M), sex, age, LDH, ECOG performance status (PS), subtypes, and tumor sites were assessed in relation to clinical outcome. The median follow-up time was 46.6 months (range 1.3-158.6). The estimated 5-year OS rate was 74.22%. In gastric lymphoma ,the 5-year OS rate was well correlated with stage in the TNM system (stage I 100.00%, stage II 87.18%, stage III 75.17%, and stage IV 16.67%. pAnn Arbor systems (69.47% in stage IIE, 66.67% in stage IIIE). In aggressive lymphomas, the 5-year OS of TNM stage I, stage II, stage III , and stage IV was 100.00%, 81.34%, 63.52%, and 16.00%, respectively (p=0.0002), but there were overlapped survival curves in Lugano and Ann Arbor systems. The 5-year OS of patients with T1 or T2 was significantly superior compared to patients with T3 or T4 (96.15 vs 67.92%, p=0.0087), and multivariate Cox analysis showed that T (p=0.0181) and M (p=0.0031) were the covariates prognostically significant for OS. TNM staging system may be superior to Lugano and Ann Arbor system in predicting OS of patients with PGL.

  16. America's Next Great Ship: Space Launch System Core Stage Transitioning from Design to Manufacturing

    Science.gov (United States)

    Birkenstock, Benjamin; Kauer, Roy

    2014-01-01

    The Space Launch System (SLS) Program is essential to achieving the Nation's and NASA's goal of human exploration and scientific investigation of the solar system. As a multi-element program with emphasis on safety, affordability, and sustainability, SLS is becoming America's next great ship of exploration. The SLS Core Stage includes avionics, main propulsion system, pressure vessels, thrust vector control, and structures. Boeing manufactures and assembles the SLS core stage at the Michoud Assembly Facility (MAF) in New Orleans, LA, a historical production center for Saturn V and Space Shuttle programs. As the transition from design to manufacturing progresses, the importance of a well-executed manufacturing, assembly, and operation (MA&O) plan is crucial to meeting performance objectives. Boeing employs classic techniques such as critical path analysis and facility requirements definition as well as innovative approaches such as Constraint Based Scheduling (CBS) and Cirtical Chain Project Management (CCPM) theory to provide a comprehensive suite of project management tools to manage the health of the baseline plan on both a macro (overall project) and micro level (factory areas). These tools coordinate data from multiple business systems and provide a robust network to support Material & Capacity Requirements Planning (MRP/CRP) and priorities. Coupled with these tools and a highly skilled workforce, Boeing is orchestrating the parallel buildup of five major sub assemblies throughout the factory. Boeing and NASA are transforming MAF to host state of the art processes, equipment and tooling, the most prominent of which is the Vertical Assembly Center (VAC), the largest weld tool in the world. In concert, a global supply chain is delivering a range of structural elements and component parts necessary to enable an on-time delivery of the integrated Core Stage. SLS is on plan to launch humanity into the next phase of space exploration.

  17. Application of a combined three-stage system for reclamation of tunnel construction wastewater.

    Science.gov (United States)

    Kim, Jong-Oh; Cho, Kyung Hwa; Park, Tae-Won; Lim, Seong-Rin; Kang, Seokkoo; Kim, Young Mo

    2015-01-01

    A combined three-stage system, (1) coagulation (2) zeocarbon filtration and (3) membrane filtration, a combination of microfiltration (MF) and reverse osmosis (RO), was investigated for reclamation of tunnel construction wastewater having a salinity of 10.8-12.9‰ and a concentration of suspended solids (SS) in the range of 264-1084 mg/L. The initial stages - coagulation, zeocarbon filtration and MF - served as a precursor to RO membrane filtration to successfully reduce water contaminants to less than 0.2 nephelometric turbidity units (NTU) of turbidity, thereby minimizing the potential for fouling. The RO system subsequently removed over 99% of remaining pollutants including ionic substances, resulting in less than 0.02 NTU turbidity, less than 0.04 mg/L total nitrogen (TN) and less than 0.01 mg/L total phosphorus (TP). Also, addition of an RO system markedly reduced high salt concentrations (high chloride (Cl(-)) concentrations) in the wastewater, exceeding 99% salt elimination. Thus, reclaimed water from our combined system met and exceeded currently regulatory quality standards for wastewater reuse (turbidity ≤ 2.0 NTU; TN ≤ 10 mg/L; TP ≤ 0.5 mg/L; Cl(-) ≤ 250 mg/L).

  18. Study on Wireless Network Communication in Stage Hydraulic Monitoring System Based on Internet of Things

    Directory of Open Access Journals (Sweden)

    Yue Dong

    2015-01-01

    Full Text Available A novel stage hydraulic monitoring system based on Internet of Things (IoT is proposed in this paper. Compared with the traditional wired system, the proposed system is a flexible working method and can save the cost. Furthermore, it has the low power consumption, high safety, and large scale network. The real-time pressure and flow data can be collected by using the nodes in ZigBee network. The fault detection and diagnosis process was used in this study, which was facilitated by measuring pressure of flow. When the monitored data exceeds the normal range, some failure may occur in the stage hydraulic system. If any failure occurs in the circuit, the maintainers can be informed immediately, which can greatly improve maintenance efficiency, ensuring the failure to be eliminated in time. Meanwhile, we can take advantage of wireless sensor network (WSN to connect the multiple loops and then monitor the loops by using ZigBee technology, which greatly improves the efficiency of monitoring.

  19. Comparative study between two different staging systems (AJCC TNM VS BALLANTYNE’S) for mucosal melanomas of the Head & Neck

    Science.gov (United States)

    Aguilar-Romero, Madeleine; Villavicencio-Valencia, Verónica; Zepeda-Castilla, Ernesto; Vidrio-Morgado, Horacio; Peteuil, Nathalie; Mosqueda-Taylor, Adalberto

    2016-01-01

    Background Mucosal melanoma (MM) of head and neck (H &N) is a rare entity with a quite poor prognosis. Ballantyne’s staging system has been commonly used since 1970. In the 7th edition of the AJCC Staging Manual a new chapter for the staging of TNM Classification system for mucosal melanoma (MM) of the head and neck (H &N) has been introduced to reflect the particularly aggressive biological behavior of this neoplasm. The aim of this study was to analyze and compare among Ballantyne’s staging system vs TNM H &N in terms of overall survival (OS) and disease-free survival (DFS) in a consecutive population of patients with MM in a cancer centre. Material and Methods Descriptive analysis of demographic, clinical and pathological variables of MM of the Head & Neck were performed. We compared the survival curves for both systems according to the Kaplan-Meier method using the Log-rank test. Results An up-staging migration effect from Ballantyne’s localized disease to moderately and very advanced disease according to AJCC staging system. The 5-year DFS and OS for Ballantyne’s Localized Disease and AJCC Stage III were 31% and 36% vs. 47% and 50%, respectively. For locoregional disease the 5-year DFS / OS were 5% / 10% for Bal-lantyne’s system vs. 13.8% / 17.8% and 0 / 0% for AJCC Stages IVA and IVB, respectively. Conclusions In this series, the TNM staging system for MM of the H &N predicted better the prognosis of the disease when comparing with Ballantyne’s system. Key words:Head and neck, mucosal melanoma, AJCC TNM, Ballantynes´s staging system. PMID:27031071

  20. Analysis of stage and clinical/prognostic factors for colon and rectal cancer from SEER registries: AJCC and collaborative stage data collection system.

    Science.gov (United States)

    Chen, Vivien W; Hsieh, Mei-Chin; Charlton, Mary E; Ruiz, Bernardo A; Karlitz, Jordan; Altekruse, Sean F; Ries, Lynn A G; Jessup, J Milburn

    2014-12-01

    The Collaborative Stage (CS) Data Collection System enables multiple cancer registration programs to document anatomic and molecular pathology features that contribute to the Tumor (T), Node (N), Metastasis (M) - TNM - system of the American Joint Committee on Cancer (AJCC). This article highlights changes in CS for colon and rectal carcinomas as TNM moved from the AJCC 6th to the 7th editions. Data from 18 Surveillance, Epidemiology, and End Results (SEER) population-based registries were analyzed for the years 2004-2010, which included 191,361colon and 73,341 rectal carcinomas. Overall, the incidence of colon and rectal cancers declined, with the greatest decrease in stage 0. The AJCC's 7th edition introduction of changes in the subcategorization of T4, N1, and N2 caused shifting within stage groups in 25,577 colon and 10,150 rectal cancers diagnosed in 2010. Several site-specific factors (SSFs) introduced in the 7th edition had interesting findings: 1) approximately 10% of colon and rectal cancers had tumor deposits - about 30%-40% occurred without lymph node metastases, which resulted in 2.5% of colon and 3.3% of rectal cases becoming N1c (stage III A/B) in the AJCC 7th edition; 2) 10% of colon and 12% of rectal cases had circumferential radial margins Cancer Society.

  1. Cortical adaptation staging system: a new and simple staging for result evaluation of functioning free-muscle transplantation for facial reanimation.

    Science.gov (United States)

    Tzou, Chieh-Han John; Chuang, David Chwei-Chin; Chen, Hsin-Yu Sirena

    2014-07-01

    Movement-associated cortical reorganization occurs in patients after functioning free-muscle transplantation (FFMT), which is reinnervated by different neurotizers. Aiming to evaluate the process of recovery of the reinnervated muscle, we defined the cortical reorganization into 5 stages. This staging system has been applied during the past 25 years at our center with great convenience and accessibility. A standardized evaluation method for assessing the recovery after FFMT to reanimate the paralyzed face with at least a 1-year follow-up was applied. The evaluation included the following 5 stages: no movement, dependent movement, independent movement, and spontaneous movement with and without involuntary movement. Reliability of this technique was assessed by 3 examiners, who each evaluated the smiles of 30 unilateral facial paralysis patients 4 times, creating 360 sets of measurements. The intraclass correlation coefficients for interrater and intrarater reliability exceeded 0.929, which is considered excellent and reliable. Chuang's Cortical Adaptation Staging System is simple, quick,and accurate in evaluating patients after FFMT reanimation of the paralyzed face with no additional tools.

  2. Evaluation of Eight Different Clinical Staging Systems Associated with Overall Survival of Chinese Patients with Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Jian-Jun Zhao

    2015-01-01

    Full Text Available Background: Hepatocellular carcinoma (HCC is a common cancer in China, an area of high hepatitis B virus (HBV infection. Although several staging systems are available, there is no consensus on the best classification to use because multiple factors, such as etiology, clinical treatment and populations could affect the survival of HCC patients. Methods: This study analyzed 743 HBV-related Chinese HCC patients who received surgery first and evaluated the predictive values of eight different commonly used staging systems in the clinic. Results: The overall 1-, 3-, 5-year survival rates and a median survival were 91.5%, 70.3%, 55.3% and 72 months respectively. Barcelona Clinic Liver Cancer (BCLC staging systems had the best stratification ability and showed the lowest Akaike information criterion (AIC values (2896.577, followed by tumor-node-metastasis 7 th (TNM 7 th (AIC = 2899.980, TNM 6 th (AIC = 2902.17, Japan integrated staging score (AIC = 2918.085, Tokyo (AIC = 2938.822, Cancer of the Liver Italian Program score (AIC = 2941.950, Chinese University Prognostic Index grade (AIC = 2962.027, and Okuda (AIC = 2979.389. Conclusions: BCLC staging system is a better staging model for HBV infection patients with HCC in Chinese population among the eight currently used staging systems. These identifications afford a large group of Chinese HCC patients with HBV infection and could be helpful to design a new staging system for a certain population.

  3. Analysis of effects of a new environmental pollutant, bisphenol A, on antioxidant systems in soybean roots at different growth stages

    Science.gov (United States)

    Zhang, Jiazhi; Li, Xingyi; Zhou, Li; Wang, Lihong; Zhou, Qing; Huang, Xiaohua

    2016-03-01

    Bisphenol A (BPA) is an important industrial raw material. Because of its widespread use and increasing release into environment, BPA has become a new environmental pollutant. Previous studies about BPA’s effects in plants focus on a certain growth stage. However, the plant’s response to pollutants varies at different growth stages. Therefore, in this work, BPA’s effects in soybean roots at different growth stages were investigated by determining the reactive oxygen species levels, membrane lipid fatty acid composition, membrane lipid peroxidation, and antioxidant systems. The results showed that low-dose BPA exposure slightly caused membrane lipid peroxidation but didn’t activate antioxidant systems at the seedling stage, and this exposure did not affect above process at other growth stages; high-dose BPA increased reactive oxygen species levels and then caused membrane lipid peroxidation at all growth stages although it activated antioxidant systems, and these effects were weaker with prolonging the growth stages. The recovery degree after withdrawal of BPA exposure was negatively related to BPA dose, but was positively related to growth stage. Taken together, the effects of BPA on antioxidant systems in soybean roots were associated with BPA exposure dose and soybean growth stage.

  4. Construction of a 300-keV compact ion microbeam system with a three-stage acceleration lens

    Energy Technology Data Exchange (ETDEWEB)

    Ishii, Yasuyuki, E-mail: ishii.yasuyuki@jaea.go.jp; Ohkubo, Takeru; Kojima, Takuji; Kamiya, Tomihiro

    2014-08-01

    Hydrogen ion microbeams were experimentally formed at beam energies below 150 keV using a 300-keV compact microbeam system that was constructed at the Japan Atomic Energy Agency. This paper is a preliminary report on the performance of the three-stage acceleration lens used in the compact microbeam system. This system consists of a three-stage acceleration lens and a plasma-type ion source. Since the three-stage acceleration lens was designed to simultaneously accelerate and focus the ion beam, the compact microbeam system is only about 1-m high and can be placed in a small experimental room. To evaluate the effectiveness of the three-stage acceleration lens, experimentally measured beam sizes are compared with theoretically calculated ones. The calculated and measured beam sizes were consistent within 10%. This shows that the three-stage acceleration lens is effective as a focusing lens for forming microbeams.

  5. Staged Optimization Design for Updating Urban Drainage Systems in a City of China

    Directory of Open Access Journals (Sweden)

    Kui Xu

    2018-01-01

    Full Text Available Flooding has been reported more often than in the past in most cities of China in recent years. In response, China’s State Council has urged the 36 largest cities to update the preparedness to handle the 50-year rainfall, which would be a massive project with large investments. We propose a staged optimization design for updating urban drainage that is not only a flexible option against environmental changes, but also an effective way to reduce the cost of the project. The staged cost optimization model involving the hydraulic model was developed in Fuzhou City, China. This model was established to minimize the total present costs, including intervention costs and flooding costs, with full consideration of the constraints of specific local conditions. The results show that considerable financial savings could be achieved by a staged design rather than the implement-once scheme. The model’s sensitivities to four data parameters were analyzed, including rainfall increase rate, flood unit cost, storage unit cost, and discount rate. The results confirm the applicability and robustness of the model for updating drainage systems to meet the requirements. The findings of this study may have important implications on urban flood management in the cities of developing countries with limited construction investments.

  6. Evaluation of high step-up power electronics stages in thermoelectric generator systems

    DEFF Research Database (Denmark)

    Sun, Kai; Ni, Longxian; Chen, Min

    2013-01-01

    To develop practical thermoelectric generator (TEG) systems, especially radioisotope thermoelectric power supplies for deep-space exploration, a power conditioning stage with high step-up gain is indispensable. This stage is used to step up the low output voltage of thermoelectric generators to t...... efficiency and input current ripples. The interleaved boost converter with an auxiliary transformer is found to be the most suitable topology for TEG applications, which is verified by experiments....... to the required high level. Furthermore, maximum power point tracking control for TEG modules needs to be implemented into the power electronics stages. In this paper, the temperature-dependent electrical characteristics of a thermoelectric generator are analyzed in depth. Three typical high step-up power...... converters suitable for TEG applications are discussed: an interleaved boost converter, a boost converter with a coupled inductor and an interleaved boost converter with an auxiliary transformer. A general comparison of the three high step-up converters is conducted to study the step-up gain, conversion...

  7. Aluminum 2195 T8 Gore Development for Space Launch System Core and Upper Stage

    Science.gov (United States)

    Volz, Martin

    2015-01-01

    Gores are pie-shaped panels that are welded together to form the dome ends of rocket fuel tanks as shown in figure 1. Replacing aluminum alloy 2219 with aluminum (Al)-lithium (Li) alloy 2195 as the Space Launch System (SLS) cryogenic tank material would save enormous amounts of weight. In fact, it has been calculated that simply replacing Al 2219 gores with Al 2195 gores on the SLS core stage domes could save approximately 3,800 pound-mass. This is because the Al-Li 2195 alloy exhibits both higher mechanical properties and lower density than the SLS baseline Al 2219 alloy. Indeed, the known advantages of Al 2195 led to its use as a replacement for Al 2219 in the shuttle external tank program. The required thicknesses of Al 2195 gores for either SLS core stage tanks or upper stage tanks will depend on the specific design configurations. The required thicknesses or widths may exceed the current experience base in the manufacture of such gores by the stretch-forming process. Accordingly, the primary objective of this project was to enhance the formability of Al 2195 by optimizing the heat treatment and stretch-forming process for gore thicknesses up to 0.75 inches, which envelop the maximum expected gore thicknesses for SLS tank configurations.

  8. Multifunctional Solar Systems Based On Two-Stage Regeneration Absorbent Solution

    Directory of Open Access Journals (Sweden)

    Doroshenko A.V.

    2015-04-01

    Full Text Available The concepts of multifunctional dehumidification solar systems, heat supply, cooling, and air conditioning based on the open absorption cycle with direct absorbent regeneration developed. The solar systems based on preliminary drainage of current of air and subsequent evaporated cooling. The solar system using evaporative coolers both types (direct and indirect. The principle of two-stage regeneration of absorbent used in the solar systems, it used as the basis of liquid and gas-liquid solar collectors. The main principle solutions are designed for the new generation of gas-liquid solar collectors. Analysis of the heat losses in the gas-liquid solar collectors, due to the mechanism of convection and radiation is made. Optimal cost of gas and liquid, as well as the basic dimensions and configuration of the working channel of the solar collector identified. Heat and mass transfer devices, belonging to the evaporative cooling system based on the interaction between the film and the gas stream and the liquid therein. Multichannel structure of the polymeric materials used to create the tip. Evaporative coolers of water and air both types (direct and indirect are used in the cooling of the solar systems. Preliminary analysis of the possibilities of multifunctional solar absorption systems made reference to problems of cooling media and air conditioning on the basis of experimental data the authors. Designed solar systems feature low power consumption and environmental friendliness.

  9. Proteomics-based systems biology modeling of bovine germinal vesicle stage oocyte and cumulus cell interaction.

    Directory of Open Access Journals (Sweden)

    Divyaswetha Peddinti

    Full Text Available BACKGROUND: Oocytes are the female gametes which establish the program of life after fertilization. Interactions between oocyte and the surrounding cumulus cells at germinal vesicle (GV stage are considered essential for proper maturation or 'programming' of oocytes, which is crucial for normal fertilization and embryonic development. However, despite its importance, little is known about the molecular events and pathways involved in this bidirectional communication. METHODOLOGY/PRINCIPAL FINDINGS: We used differential detergent fractionation multidimensional protein identification technology (DDF-Mud PIT on bovine GV oocyte and cumulus cells and identified 811 and 1247 proteins in GV oocyte and cumulus cells, respectively; 371 proteins were significantly differentially expressed between each cell type. Systems biology modeling, which included Gene Ontology (GO and canonical genetic pathway analysis, showed that cumulus cells have higher expression of proteins involved in cell communication, generation of precursor metabolites and energy, as well as transport than GV oocytes. Our data also suggests a hypothesis that oocytes may depend on the presence of cumulus cells to generate specific cellular signals to coordinate their growth and maturation. CONCLUSIONS/SIGNIFICANCE: Systems biology modeling of bovine oocytes and cumulus cells in the context of GO and protein interaction networks identified the signaling pathways associated with the proteins involved in cell-to-cell signaling biological process that may have implications in oocyte competence and maturation. This first comprehensive systems biology modeling of bovine oocytes and cumulus cell proteomes not only provides a foundation for signaling and cell physiology at the GV stage of oocyte development, but are also valuable for comparative studies of other stages of oocyte development at the molecular level.

  10. Water erosion and soil water infiltration in different stages of corn development and tillage systems

    Directory of Open Access Journals (Sweden)

    Daniel F. de Carvalho

    2015-11-01

    Full Text Available ABSTRACTThis study evaluated soil and water losses, soil water infiltration and infiltration rate models in soil tillage systems and corn (Zea mays, L. development stages under simulated rainfall. The treatments were: cultivation along contour lines, cultivation down the slope and exposed soil. Soil losses and infiltration in each treatment were quantified for rains applied using a portable simulator, at 0, 30, 60 and 75 days after planting. Infiltration rates were estimated using the models of Kostiakov-Lewis, Horton and Philip. Based on the obtained results, the combination of effects between soil tillage system and corn development stages reduces soil and water losses. The contour tillage system promoted improvements in soil physical properties, favoring the reduction of erosion in 59.7% (water loss and 86.6% (soil loss at 75 days after planting, and the increase in the stable infiltration rate in 223.3%, compared with the exposed soil. Associated to soil cover, contour cultivation reduces soil and water losses, and the former is more influenced by management. Horton model is the most adequate to represent soil water infiltration rate under the evaluated conditions.

  11. Dialysis for end stage renal disease financed through the Brazilian National Health System, 2000 to 2012

    Science.gov (United States)

    2014-01-01

    Background Chronic kidney disease has become a public health problem worldwide. Its terminal stage requires renal replacement therapy – dialysis or transplantation – for the maintenance of life, resulting in high economic and social costs. Though the number of patients with end-stage renal disease treated by dialysis in Brazil is among the highest in the world, current estimates of incidence and prevalence are imprecise. Our aim is to describe incidence and prevalence trends and the epidemiologic profile of end-stage renal disease patients receiving publically-financed dialysis in Brazil between 2000 and 2012. Methods We internally linked records of the High Complexity Procedure Authorization/Renal Replacement Therapy (APAC/TRS) system so as to permit analyses of incidence and prevalence of dialysis over the period 2000-2012. We characterized temporal variations in the incidence and prevalence using Joinpoint regression. Results Over the period, 280,667 patients received publically-financed dialysis, 57.2% of these being male. The underlying disease causes listed were hypertension (20.8%), diabetes (12.0%) and glomerulonephritis (7.7%); for 42.3%, no specific cause was recorded. Hemodialysis was the therapeutic modality in 90.1%. Over this period, prevalence increased 47%, rising 3.6% (95% CI 3.2% - 4.0%)/year. Incidence increased 20%, or 1.8% (1.1% – 2.5%)/year. Incidence increased in both sexes, in all regions of the country and particularly in older age groups. Conclusions Incidence and prevalence of end-stage renal disease receiving publically-financed dialysis treatment has increased notably. The linkage approach developed will permit continuous future monitoring of these indicators. PMID:25008169

  12. Markers, Cofactors and Staging Systems in the Study of HIV Disease Progression: A Review

    Directory of Open Access Journals (Sweden)

    MC Portela

    1997-07-01

    Full Text Available This paper is aimed at providing a comprehensive review of markers, cofactors and staging systems used for HIV disease, focusing on some aspects that nowadays could even be considered historical, and advancing in current issues such as the prognostic value of viral load measurements, viral genotypic and phenotypic characterization, and new HIV disease treatment protocols. CD4+ cell values, combined with the new viral markers mentioned are promising as a parsimonious predictor set for defining both severity and progression. An adequate predictor of patient resource use for planning purposes still needs to be defined

  13. Thermal Efficiency of Cogeneration Units with Multi-Stage Reheating for Russian Municipal Heating Systems

    Directory of Open Access Journals (Sweden)

    Evgeny Lisin

    2016-04-01

    Full Text Available This paper explores the layout of an optimum process for supplying heat to Russian municipal heating systems operating in a market environment. We analyze and compare the standard cogeneration unit design with two-stage reheating of service water coming from controlled extraction locations and layouts that employ three in-line reheaters with heat the supply controlled by a rotary diaphragm and qualitative/quantitative methods (so-called “uncontrolled extraction”. Cogeneration unit designs are benchmarked in terms of their thermal efficiency expressed as a fuel consumption rate. The specific fuel consumption rate on electricity production is viewed as a key parameter of thermal efficiency.

  14. Grating exchange system of independent mirror supported by floating rotary stage

    Science.gov (United States)

    Zhang, Jianhuan; Tao, Jin; Liu, Yan; Nan, Yan

    2015-10-01

    The performance of The Grating Exchange System can satisfy the Thirty Meter Telescope - TMT for astronomical observation WFOS index requirements and satisfy the requirement of accuracy in the grating exchange. It is used to install in the MOBIE and a key device of MOBIE. The Wide Field Optical Spectrograph (WFOS) is one of the three first-light observing capabilities selected by the TMT Science Advisory Committee. The Multi-Object Broadband Imaging Echellette (MOBIE) instrument design concept has been developed to address the WFOS requirements as described in the TMT Science-Based Requirements Document (SRD). The Grating Exchange System uses a new type of separate movement way of three grating devices and a mirror device. Three grating devices with a mirror are able to achieve independence movement. This kind of grating exchange system can effectively solve the problem that the volume of the grating change system is too large and that the installed space of MOBIE instruments is too limit. This system adopts the good stability, high precision of rotary stage - a kind of using air bearing (Air bearing is famous for its ultra-high precision, and can meet the optical accuracy requirement) and rotation positioning feedback gauge turntable to support grating device. And with a kind of device which can carry greater weight bracket fixed on the MOBIE instrument, with two sets of servo motor control rotary stage and the mirror device respectively. And we use the control program to realize the need of exercising of the grating device and the mirror device. Using the stress strain analysis software--SolidWorks for stress and strain analysis of this structure. And then checking the structure of the rationality and feasibility. And prove that this system can realize the positioning precision under different working conditions can meet the requirements of imaging optical grating diffraction efficiency and error by the calculation and optical performance analysis.

  15. Development of the excretory system in a polyplacophoran mollusc: stages in metanephridial system development.

    Science.gov (United States)

    Baeumler, Natalie; Haszprunar, Gerhard; Ruthensteiner, Bernhard

    2012-09-14

    Two types of excretory systems, protonephridia and metanephridial systems are common among bilaterians. The homology of protonephridia of lophotrochozoan taxa has been widely accepted. In contrast, the homology of metanephridial systems - including coelomic cavities as functional units - among taxa as well as the homology between the two excretory systems is a matter of ongoing discussion. This particularly concerns the molluscan kidneys, which are mostly regarded as being derived convergently to the metanephridia of e.g. annelids because of different ontogenetic origin. A reinvestigation of nephrogenesis in polyplacophorans, which carry many primitive traits within molluscs, could shed light on these questions. The metanephridial system of Lepidochitona corrugata develops rapidly in the early juvenile phase. It is formed from a coelomic anlage that soon achieves endothelial organization. The pericardium and heart are formed from the central portion of the anlage. The nephridial components are formed by outgrowth from lateral differentiations of the anlage. Simultaneously with formation of the heart, podocytes appear in the atrial wall of the pericardium. In addition, renopericardial ducts, kidneys and efferent nephroducts, all showing downstream ciliation towards the internal lumen, become differentiated (specimen length: 0.62 mm). Further development consists of elongation of the kidney and reinforcement of filtration and reabsorptive structures. During development and in fully formed condition the metanephridial system of Lepidochitona corrugata shares many detailed traits (cellular and overall organization) with the protonephridia of the same species. Accordingly, we suggest a serial homology of various cell types and between the two excretory systems and the organs as a whole. The formation of the metanephridial system varies significantly within Mollusca, thus the mode of formation cannot be used as a homology criterion. Because of similarities in overall

  16. Proposed Staging System for Patients With HPV-Related Oropharyngeal Cancer Based on Nasopharyngeal Cancer N Categories.

    Science.gov (United States)

    Dahlstrom, Kristina R; Garden, Adam S; William, William N; Lim, Ming Yann; Sturgis, Erich M

    2016-06-01

    Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) generally present with more advanced disease but have better survival than patients with HPV-unrelated OPC. The current American Joint Commission on Cancer (AJCC)/Union for International Cancer Control (UICC) TNM staging system for OPC was developed for HPV-unrelated OPC. A new staging system is needed to adequately predict outcomes of patients with HPV-related OPC. Patients with newly diagnosed HPV-positive OPC (by p16 immunohistochemistry or in situ hybridization) treated at our institution from January 2003 through December 2012 were included. By using recursive partitioning analysis (RPA), we developed new stage groupings with both traditional OPC regional lymph node (N) categories and nasopharyngeal carcinoma (NPC) N categories. Survival was estimated by the Kaplan-Meier method, and the relationship between stage and survival was examined by using Cox proportional hazards regression analysis. A total of 661 patients with HPV-positive OPC met the inclusion criteria. With the traditional TNM staging system, there was no difference in survival between stages (P = .141). RPA with NPC N categories resulted in more balanced stage groups and better separation between groups for 5-year survival than RPA with traditional OPC N categories. With the stage groupings that were based in part on NPC N categories, the risk of death increased with increasing stage (P for trend HPV-positive OPC with respect to survival than does the current AJCC/UICC TNM staging system. Although confirmation of our findings in other patient populations is needed, we propose consideration of NPC N categories as an alternative to the traditional OPC N categories in the new AJCC/UICC TNM staging system that is currently being developed. © 2016 by American Society of Clinical Oncology.

  17. Nervous system development in lecithotrophic larval and juvenile stages of the annelid Capitella teleta.

    Science.gov (United States)

    Meyer, Néva P; Carrillo-Baltodano, Allan; Moore, Richard E; Seaver, Elaine C

    2015-01-01

    larvogenesis in C. teleta persists into the juvenile stage. The first neurons differentiate in the brain, which contrasts with the early formation of peripheral, larval-specific neurons found in some spiralian taxa with planktotrophic larvae. Our study provides a clear indication that certain shared features among annelids - e.g., five connectives in the ventral nerve cord - are only visible during larval stages in particular species, emphasizing the need to include developmental data in ancestral character state reconstructions. The data provided in this paper will serve as an important comparative reference for understanding evolution of nervous systems, and as a framework for future molecular studies of development.

  18. Evaluation of Pachymetric Measurements with Scheimpflug Photography-Based System and Optical Coherence Tomography Pachymetry at Different Stages of Keratoconus

    Directory of Open Access Journals (Sweden)

    Betül İlkay Sezgin Akçay

    2014-01-01

    Full Text Available The aim of this study was to compare the central and peripheral pachymetric measurements determined with Sirius system and Visante OCT and evaluate the agreement between them at different stages of keratoconus. Measurements were not significantly different in all patients and subgroups and showed high correlation for the corneal thicknesses of the entire cornea in different stages of keratoconus.

  19. The Effect of Effluent Recirculation in a Semi-Continuous Two-Stage Anaerobic Digestion System

    Directory of Open Access Journals (Sweden)

    Karthik Rajendran

    2013-06-01

    Full Text Available The effect of recirculation in increasing organic loading rate (OLR and decreasing hydraulic retention time (HRT in a semi-continuous two-stage anaerobic digestion system using stirred tank reactor (CSTR and an upflow anaerobic sludge bed (UASB was evaluated. Two-parallel processes were in operation for 100 days, one with recirculation (closed system and the other without recirculation (open system. For this purpose, two structurally different carbohydrate-based substrates were used; starch and cotton. The digestion of starch and cotton in the closed system resulted in production of 91% and 80% of the theoretical methane yield during the first 60 days. In contrast, in the open system the methane yield was decreased to 82% and 56% of the theoretical value, for starch and cotton, respectively. The OLR could successfully be increased to 4 gVS/L/day for cotton and 10 gVS/L/day for starch. It is concluded that the recirculation supports the microorganisms for effective hydrolysis of polyhydrocarbons in CSTR and to preserve the nutrients in the system at higher OLRs, thereby improving the overall performance and stability of the process.

  20. Computerized breast cancer analysis system using three stage semi-supervised learning method.

    Science.gov (United States)

    Sun, Wenqing; Tseng, Tzu-Liang Bill; Zhang, Jianying; Qian, Wei

    2016-10-01

    A large number of labeled medical image data is usually a requirement to train a well-performed computer-aided detection (CAD) system. But the process of data labeling is time consuming, and potential ethical and logistical problems may also present complications. As a result, incorporating unlabeled data into CAD system can be a feasible way to combat these obstacles. In this study we developed a three stage semi-supervised learning (SSL) scheme that combines a small amount of labeled data and larger amount of unlabeled data. The scheme was modified on our existing CAD system using the following three stages: data weighing, feature selection, and newly proposed dividing co-training data labeling algorithm. Global density asymmetry features were incorporated to the feature pool to reduce the false positive rate. Area under the curve (AUC) and accuracy were computed using 10 fold cross validation method to evaluate the performance of our CAD system. The image dataset includes mammograms from 400 women who underwent routine screening examinations, and each pair contains either two cranio-caudal (CC) or two mediolateral-oblique (MLO) view mammograms from the right and the left breasts. From these mammograms 512 regions were extracted and used in this study, and among them 90 regions were treated as labeled while the rest were treated as unlabeled. Using our proposed scheme, the highest AUC observed in our research was 0.841, which included the 90 labeled data and all the unlabeled data. It was 7.4% higher than using labeled data only. With the increasing amount of labeled data, AUC difference between using mixed data and using labeled data only reached its peak when the amount of labeled data was around 60. This study demonstrated that our proposed three stage semi-supervised learning can improve the CAD performance by incorporating unlabeled data. Using unlabeled data is promising in computerized cancer research and may have a significant impact for future CAD system

  1. A two-stage preventive maintenance policy for a multi-state deterioration system

    International Nuclear Information System (INIS)

    Huang, C.-C.; Yuan, John

    2010-01-01

    This paper is to propose a two-stage preventive maintenance (PM) policy for the multi-state deterioration system under periodic inspection and with multiple candidate actions for PM. Such policy is mainly to schedule PM optimally and also on how to choose the action optimally for each PM. The scheduling includes two tasks: to determine after completing each PM when to make the decision and then at it to schedule the next PM optimally. We assume that: (1) such actions except replacement are imperfect, (2) the inspection and action times can be ignored, (3) the system can be modeled by a multi-state discrete time Markov chain whose transition probabilities will change and be updated only at the instant after completing each PM, and (4) the risks of such imperfect actions will be updated only at the instant after completing each PM. Finally, an example through simulation is presented to illustrate how such policy can be carried out.

  2. Systems and methods for cylindrical hall thrusters with independently controllable ionization and acceleration stages

    Science.gov (United States)

    Diamant, Kevin David; Raitses, Yevgeny; Fisch, Nathaniel Joseph

    2014-05-13

    Systems and methods may be provided for cylindrical Hall thrusters with independently controllable ionization and acceleration stages. The systems and methods may include a cylindrical channel having a center axial direction, a gas inlet for directing ionizable gas to an ionization section of the cylindrical channel, an ionization device that ionizes at least a portion of the ionizable gas within the ionization section to generate ionized gas, and an acceleration device distinct from the ionization device. The acceleration device may provide an axial electric field for an acceleration section of the cylindrical channel to accelerate the ionized gas through the acceleration section, where the axial electric field has an axial direction in relation to the center axial direction. The ionization section and the acceleration section of the cylindrical channel may be substantially non-overlapping.

  3. Optimization of Adaboost Algorithm for Sonar Target Detection in a Multi-Stage ATR System

    Science.gov (United States)

    Lin, Tsung Han (Hank)

    2011-01-01

    JPL has developed a multi-stage Automated Target Recognition (ATR) system to locate objects in images. First, input images are preprocessed and sent to a Grayscale Optical Correlator (GOC) filter to identify possible regions-of-interest (ROIs). Second, feature extraction operations are performed using Texton filters and Principal Component Analysis (PCA). Finally, the features are fed to a classifier, to identify ROIs that contain the targets. Previous work used the Feed-forward Back-propagation Neural Network for classification. In this project we investigate a version of Adaboost as a classifier for comparison. The version we used is known as GentleBoost. We used the boosted decision tree as the weak classifier. We have tested our ATR system against real-world sonar images using the Adaboost approach. Results indicate an improvement in performance over a single Neural Network design.

  4. Dual-stage periodic event-triggered output-feedback control for linear systems.

    Science.gov (United States)

    Ruan, Zhen; Chen, Wu-Hua; Lu, Xiaomei

    2018-03-22

    This paper proposes an event-triggered control framework, called dual-stage periodic event-triggered control (DSPETC), which unifies periodic event-triggered control (PETC) and switching event-triggered control (SETC). Specifically, two period parameters h 1 and h 2 are introduced to characterize the new event-triggering rule, where h 1 denotes the sampling period, while h 2 denotes the monitoring period. By choosing some specified values of h 2 , the proposed control scheme can reduce to PETC or SETC scheme. In the DSPETC framework, the controlled system is represented as a switched system model and its stability is analyzed via a switching-time-dependent Lyapunov functional. Both the cases with/without network-induced delays are investigated. Simulation and experimental results show that the DSPETC scheme is superior to the PETC scheme and the SETC scheme. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

  5. Utilizing Photogrammetry and Strain Gage Measurement to Characterize Pressurization of Inflatable Modules

    Science.gov (United States)

    Mohammed, Anil

    2011-01-01

    This paper focuses on integrating a large hatch penetration into inflatable modules of various constructions. This paper also compares load predictions with test measurements. The strain was measured by utilizing photogrammetric methods and strain gages mounted to select clevises that interface with the structural webbings. Bench testing showed good correlation between strain data collected from an extensometer and photogrammetric measurements, even when the material transitioned from the low load to high load strain region of the curve. The full-scale torus design module showed mixed results as well in the lower load and high strain regions. After thorough analysis of photogrammetric measurements, strain gage measurements, and predicted load, the photogrammetric measurements seem to be off by a factor of two.

  6. Utilizing Photogrammetry and Strain Gage Measurement to Characterize Pressurization of an Inflatable Module

    Science.gov (United States)

    Valle, Gerard D.; Selig, Molly; Litteken, Doug; Oliveras, Ovidio

    2012-01-01

    This paper documents the integration of a large hatch penetration into an inflatable module. This paper also documents the comparison of analytical load predictions with measured results utilizing strain measurement. Strain was measured by utilizing photogrammetric measurement and through measurement obtained from strain gages mounted to selected clevises that interface with the structural webbings. Bench testing showed good correlation between strain measurement obtained from an extensometer and photogrammetric measurement especially after the fabric has transitioned through the low load/high strain region of the curve. Test results for the full-scale torus showed mixed results in the lower load and thus lower strain regions. Overall strain, and thus load, measured by strain gages and photogrammetry tracked fairly well with analytical predictions. Methods and areas of improvements are discussed.

  7. Combined Load Diagram for a Wind Tunnel Strain-Gage Balance

    Science.gov (United States)

    Ulbrich, N.

    2010-01-01

    Combined Load Diagrams for Direct-Read, Force, and Moment Balances are discussed in great detail in the paper. The diagrams, if compared with a corresponding combined load plot of a balance calibration data set, may be used to visualize and interpret basic relationships between the applied balance calibration loads and the load components at the forward and aft gage of a strain-age balance. Lines of constant total force and moment are identified in the diagrams. In addition, the lines of pure force and pure moment are highlighted. Finally, lines of constant moment arm are depicted. It is also demonstrated that each quadrant of a Combined Load Diagram has specific regions where the applied total calibration force is at, between, or outside of the balance gage locations. Data from the manual calibration of a Force Balance is used to illustrate the application of a Combined Load Diagram to a realistic data set.

  8. The Effect of Modeling Qualities, Tones and Gages in Ceramic Supply Chains' Master Planning

    Directory of Open Access Journals (Sweden)

    Isabel MUNDI

    2012-01-01

    Full Text Available Ceramic production processes are characterized by providing quantities of the same finished goods that differ in qualities, tones and gages. This aspect becomes a problem for ceramic supply chains (SCs that should promise and serve customer orders with homogeneous quantities of the same finished good. In this paper a mathematical programming model for the cen-tralized master planning of ceramic SC is proposed. Inputs to the master plan include demand forecasts in terms of customer order classes based on their order size and splitting percentages of a lot into homogeneous sub-lots. Then, the master plan defines the size and loading of lots to production lines and their distribution with the aim of maximizing the number of customer orders fulfilled with homogeneous quantities in the most efficient manner for the SC. Finally, the effect of modeling qualities, tones and gages in master planning is assessed.

  9. Application of the nuclear gages in dynamic sedimentology for the solid transport study

    International Nuclear Information System (INIS)

    Lamdasni, Y.

    1994-02-01

    The problems caused by the solid particle transport in rivers, dams, harbors, estuaries and in navigation channels have considerable economical consequences. The technical difficulties met when trying to limit or manage these problems are very important because of lack of knowledge. The nuclear gages and the radioactive tracers can be the measurement and monitoring means which, associated to the conventional techniques, permit to develop strongly the knowledge in the solid transport field. This report gives the modes of solid transport and the problems caused by these transports and exposes the physical properties of the fine sediments and their behavior under the hydrodynamic effects. In the same way, it deals with the theory of the nuclear gages, often applied in dynamic sedimentology and gives some examples of their applications. 29 refs., 35 figs., 5 tabs. (F.M.)

  10. A Two-Stage Queue Model to Optimize Layout of Urban Drainage System considering Extreme Rainstorms

    Directory of Open Access Journals (Sweden)

    Xinhua He

    2017-01-01

    Full Text Available Extreme rainstorm is a main factor to cause urban floods when urban drainage system cannot discharge stormwater successfully. This paper investigates distribution feature of rainstorms and draining process of urban drainage systems and uses a two-stage single-counter queue method M/M/1→M/D/1 to model urban drainage system. The model emphasizes randomness of extreme rainstorms, fuzziness of draining process, and construction and operation cost of drainage system. Its two objectives are total cost of construction and operation and overall sojourn time of stormwater. An improved genetic algorithm is redesigned to solve this complex nondeterministic problem, which incorporates with stochastic and fuzzy characteristics in whole drainage process. A numerical example in Shanghai illustrates how to implement the model, and comparisons with alternative algorithms show its performance in computational flexibility and efficiency. Discussions on sensitivity of four main parameters, that is, quantity of pump stations, drainage pipe diameter, rainstorm precipitation intensity, and confidence levels, are also presented to provide guidance for designing urban drainage system.

  11. Single-stage Kanban system with deterioration failures and condition-based preventive maintenance

    International Nuclear Information System (INIS)

    Xanthopoulos, A.S.; Koulouriotis, D.E.; Botsaris, P.N.

    2015-01-01

    Despite the fact that the fields of pull type production control policies and condition-based preventive maintenance have much in common contextually, they have evolved independently up to now. In this investigation, an attempt is made to bridge the gap between these two branches of knowledge by introducing the single-stage Kanban system with deterioration failures and condition-based preventive maintenance. The formalism of continuous time Markov chains is used to model the system and expressions for eight performance metrics are derived. Two important, from a managerial perspective, constrained optimization problems for the proposed model are defined where the objective is the simultaneous optimization of the Kanban policy, the preventive maintenance policy and the inspection schedule under conflicting performance criteria. Multiple instances of each optimization problem are solved by means of the augmented Lagrangian genetic algorithm. The results from the optimization trials coupled by the results from extensive numerical examples facilitate the thorough investigation of the system’s behaviour. - Highlights: • Kanban system with deterioration failures and preventive maintenance is introduced. • The system is modeled as a continuous time Markov chain. • Expressions for eight performance metrics are derived. • The behavior of the system is studied through numerical examples. • Optimization results for selected performance metrics are presented

  12. The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis

    NARCIS (Netherlands)

    Capelle, Lisette G.; de Vries, Annemarie C.; Haringsma, Jelle; Ter Borg, Frank; de Vries, Richard A.; Bruno, Marco J.; van Dekken, Herman; Meijer, Jos; van Grieken, Nicole C. T.; Kuipers, Ernst J.

    Background: The OLGA (operative link on gastritis assessment) staging system is based on severity of atrophic gastritis (AG). AG remains a difficult histopathologic diagnosis with low interobserver agreement, whereas intestinal metaplasia (IM) is associated with high interobserver agreement.

  13. The development of an expert system for finding fragility curves of building structural systems in the preliminary design stage

    International Nuclear Information System (INIS)

    Yee, L.Y.; Okrent, D.

    1987-01-01

    This research is a starting point for the development of an expert system for determining seismic fragility curves of structural systems in a nuclear power plant or conventional building at the preliminary design stage. The resulting system assists an engineer with moderate engineering background and limited reliability knowledge to analyze the failure functions of building structures. It simulates the performance of an expert in identifying the potential failure modes and their variabilities for a structure of interest. On reviewing the methodology of seismic fragility evaluation for existing building structures in the nuclear power plant industry, one finds that the investigation process starts with the identification of critical components or substructures, whose failures result in the functional failure of safety related equipment or the failure of structural integrity itself, and follows with complicated numerical analyses to estimate the capacity functions associated with the limit states of these components or substructures

  14. Thermal Design and Analysis of a Multi-Stage 30K Radiative Cooling System for EPIC

    Science.gov (United States)

    Chui, Talso; Bock, Jamie; Holmes, Warren; Raab, Jeff

    2009-01-01

    The Experimental Probe of Inflationary Cosmology (EPIC) is an implementation of the NASA Einstein Inflation Probe mission, to answer questions about the physics of Inflation in the early Universe by measuring the polarization of the Cosmic Microwave Background (CMB). The mission relies on a passive cooling system to cool the enclosure of a telescope to 30 K; a cryocooler then cools this enclosure to 18 K and the telescope to 4 K. Subsequently, an adiabatic demagnetization refrigerator further cools a large focal plane to approx.100 mK. For this mission, the telescope has an aperture of 1.4 m, and the spacecraft's symmetry axis is oriented approx. 45 degrees relative to the direction of the sun. The spacecraft will be spun at approx. 0.5 rpm around this axis, which then precesses on the sky at 1 rph. The passive system must both supply the necessary cooling power for the cryocooler and meet demanding temperature stability requirements. We describe the thermal design of a passive cooling system consisting of four V-groove radiators for shielding of solar radiation and cooling the telescope to 30 K. The design realizes loads of 20 and 68 mW at the 4 K and 18 K stages on the cooler, respectively. A lower cost option for reaching 40 K with three V-groove radiators is also described. The analysis includes radiation coupling between stages of the radiators and sunshields, and parasitic conduction in the bipod support, harnesses, and ADR leads. Dynamic effects are also estimated, including the very small variations in temperature due to the scan motion of the spacecraft.

  15. Two-Stage orders sequencing system for mixed-model assembly

    Science.gov (United States)

    Zemczak, M.; Skolud, B.; Krenczyk, D.

    2015-11-01

    In the paper, the authors focus on the NP-hard problem of orders sequencing, formulated similarly to Car Sequencing Problem (CSP). The object of the research is the assembly line in an automotive industry company, on which few different models of products, each in a certain number of versions, are assembled on the shared resources, set in a line. Such production type is usually determined as a mixed-model production, and arose from the necessity of manufacturing customized products on the basis of very specific orders from single clients. The producers are nowadays obliged to provide each client the possibility to determine a huge amount of the features of the product they are willing to buy, as the competition in the automotive market is large. Due to the previously mentioned nature of the problem (NP-hard), in the given time period only satisfactory solutions are sought, as the optimal solution method has not yet been found. Most of the researchers that implemented inaccurate methods (e.g. evolutionary algorithms) to solving sequencing problems dropped the research after testing phase, as they were not able to obtain reproducible results, and met problems while determining the quality of the received solutions. Therefore a new approach to solving the problem, presented in this paper as a sequencing system is being developed. The sequencing system consists of a set of determined rules, implemented into computer environment. The system itself works in two stages. First of them is connected with the determination of a place in the storage buffer to which certain production orders should be sent. In the second stage of functioning, precise sets of sequences are determined and evaluated for certain parts of the storage buffer under certain criteria.

  16. Methodology to measure strains at high temperatures using electrical strain gages with free filaments

    International Nuclear Information System (INIS)

    Atanazio Filho, Nelson N.; Gomes, Paulo T. Vida; Scaldaferri, Denis H.B.; Silva, Luiz L. da; Rabello, Emerson G.; Mansur, Tanius R.

    2013-01-01

    An experimental methodology used for strains measuring at high temperatures is show in this work. In order to do the measurements, it was used electric strain gages with loose filaments attached to a stainless steel 304 beam with specific cements. The beam has triangular shape and a constant thickness, so the strain is the same along its length. Unless the beam surface be carefully prepared, the strain gage attachment is not efficient. The showed results are for temperatures ranging from 20 deg C to 300 deg C, but the experimental methodology could be used to measure strains at a temperature up to 900 deg C. Analytical calculations based on solid mechanics were used to verify the strain gage electrical installation and the measured strains. At a first moment, beam deformations as a temperature function were plotted. After that, beam deformations with different weighs were plotted as a temperature function. The results shown allowed concluding that the experimental methodology is trustable to measure strains at temperatures up to 300 deg C. (author)

  17. Standard Test Method for Measuring Heat Flux Using Surface-Mounted One-Dimensional Flat Gages

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2009-01-01

    1.1 This test method describes the measurement of the net heat flux normal to a surface using flat gages mounted onto the surface. Conduction heat flux is not the focus of this standard. Conduction applications related to insulation materials are covered by Test Method C 518 and Practices C 1041 and C 1046. The sensors covered by this test method all use a measurement of the temperature difference between two parallel planes normal to the surface to determine the heat that is exchanged to or from the surface in keeping with Fourier’s Law. The gages operate by the same principles for heat transfer in either direction. 1.2 This test method is quite broad in its field of application, size and construction. Different sensor types are described in detail in later sections as examples of the general method for measuring heat flux from the temperature gradient normal to a surface (1). Applications include both radiation and convection heat transfer. The gages have broad application from aerospace to biomedical en...

  18. The Hampton-Gledhill 2-stage pressure risk-assessment system.

    Science.gov (United States)

    Gledhill, Lee; Hampton, Sylvie

    Pressure ulcers are largely preventable and, therefore, patients dying of large, necrotic pressure damage is an unacceptable situation. Lee Gledhill is both a nurse and a barrister and has been involved in many cases involving nurses facing court proceedings when their patients' primary cause of death is pressure ulcers. Sylvie Hampton, has acted as expert witness in some of these cases. It became obvious to the two authors that had healthcare assistants (HCAs) been more aware of how pressure damage could be detected and then prevented, some of the supervising nurses would not have been facing legal charges. The authors decided to produce a simple method of assessing first-stage skin changes for HCAs to not only recognize these changes, but also to have a framework in place describing the actions they need to take. This framework was produced as a card (the Hampton-Gledhill 2-stage pressure risk-assessment system). The card is being validated in many nursing homes and hospitals around the UK and in Jersey.

  19. Rangelands Vegetation under Different Management Systems and Growth Stages in North Darfur State, Sudan (Range Attributes

    Directory of Open Access Journals (Sweden)

    Mohamed AAMA Mohamed

    2014-09-01

    Full Text Available This study was conducted at Um Kaddada, North Darfur State, Sudan, at two sites (closed and open for two consecutive seasons 2008 and 2009 during flowering and seed setting stages to evaluate range attributes at the locality. A split plot design was used to study vegetation attributes. Factors studied were management systems (closed and open and growth stages (flowering and seed setting. Vegetation cover, plant density, carrying capacity, and biomass production were assessed. Chemical analyses were done for selected plants to determine their nutritive values. The results showed high significant differences in vegetation attributes (density, cover and biomass production between closed and open areas. Closed areas had higher carrying capacity compared to open rangelands. Crude protein (CP and ash contents of range vegetation were found to decrease while Crude fiber (CF and Dry matter yield (DM had increased with growth. The study concluded that closed rangelands are better than open rangelands because it fenced and protected. Erosion index and vegetation degradation rate were very high. Future research work is needed to assess rangelands characteristics and habitat condition across different ecological zones in North Darfur State, Sudan.DOI: http://dx.doi.org/10.3126/ije.v3i3.11093 International Journal of Environment Vol.3(3 2014: 332-343

  20. Hypo Activity of Cholinergic System in Patients with Early Stage of Alzheimer's Disease

    International Nuclear Information System (INIS)

    Davidescu, L.; Codorean, I.; Matei, C.; Barret, O.; Mazere, J.; Guyot, M.; Rimbu, A.; Allard, M.

    2006-01-01

    Full text: Objective A cholinergic dysfunction was documented in advanced stages of Alzheimer's disease. In order to specify the cholinergic involvement in early stages, we performed a presynaptic imaging study of the cholinergic system using a vesicular Acetylcholine transporter ligand labelled with iodine 123 ( 123 I-IBVM - Iodobenzovesamicol) Materials And Methods Eight patients (5 women and 3 men, 74-89 years, MMS>23) and 8 controls (6 women and 2 men, 72-80 years, MMS>30) have been evaluated using the neuropsychological tests; cerebral SPECT was performed 6 hours after intravenous injection of 218±19 MBq of 123 I - IBVM (30 min, 3 volume, 128x128) and the 3D MRI (T1 weighted images). Acquisition data were processed by filtered retroprojection (Butterworth 5.35) and analysed with SPM software. Each examination was co-registered with the MRI of the patient, normalised in the MNI template and smoothed (10mm). Results The analyse of the group (two sample T-test, p 123 I-IBVM has been detected in the patients group, compared to the control. Conclusions Our results indicate that cholinergic dysfunctions appear very early in the development of Alzheimer's disease and affect the cortical structures involved in the attention process. Some studies are in progress to analyze imaging data with cognitive impairments of each patient. (author)

  1. Inspection logistics planning for multi-stage production systems with applications to semiconductor fabrication lines

    Science.gov (United States)

    Chen, Kyle Dakai

    Since the market for semiconductor products has become more lucrative and competitive, research into improving yields for semiconductor fabrication lines has lately received a tremendous amount of attention. One of the most critical tasks in achieving such yield improvements is to plan the in-line inspection sampling efficiently so that any potential yield problems can be detected early and eliminated quickly. We formulate a multi-stage inspection planning model based on configurations in actual semiconductor fabrication lines, specifically taking into account both the capacity constraint and the congestion effects at the inspection station. We propose a new mixed First-Come-First-Serve (FCFS) and Last-Come-First-Serve (LCFS) discipline for serving the inspection samples to expedite the detection of potential yield problems. Employing this mixed FCFS and LCFS discipline, we derive approximate expressions for the queueing delays in yield problem detection time and develop near-optimal algorithms to obtain the inspection logistics planning policies. We also investigate the queueing performance with this mixed type of service discipline under different assumptions and configurations. In addition, we conduct numerical tests and generate managerial insights based on input data from actual semiconductor fabrication lines. To the best of our knowledge, this research is novel in developing, for the first time in the literature, near-optimal results for inspection logistics planning in multi-stage production systems with congestion effects explicitly considered.

  2. Lower-energy neutron sources for increasing the sensitivity of nuclear gages for measuring the water content of bulk materials

    International Nuclear Information System (INIS)

    Bailey, S.M.

    1977-01-01

    The sensitivity of a gage using a nuclear source for measuring the water content of bulk materials, such as plastic concrete, is increased by use of a lithium or fluorine neutron nuclear source. 3 figures

  3. Comparison of microalgae cultivation in photobioreactor, open raceway pond, and a two-stage hybrid system

    Directory of Open Access Journals (Sweden)

    Rakesh R Narala

    2016-08-01

    Full Text Available In the wake of intensive fossil fuel usage and CO2 accumulation in the environment, research is targeted towards sustainable alternate bioenergy that can suffice the growing need for fuel and also that leaves a minimal carbon footprint. Oil production from microalgae can potentially be carried out more efficiently, leaving a smaller footprint and without competing for arable land or biodiverse landscapes. However, current algae cultivation systems and lipid induction processes must be significantly improved and are threatened by contamination with other algae or algal grazers. To address this issue, we have developed an efficient two-stage cultivation system using the marine microalga Tetraselmis sp. M8. This hybrid system combines exponential biomass production in positive pressure air lift-driven bioreactors with a separate synchronized high-lipid induction phase in nutrient deplete open raceway ponds. A comparison to either bioreactor or open raceway pond cultivation system suggests that this process potentially leads to significantly higher productivity of algal lipids. Nutrients are only added to the closed bioreactors while open raceway ponds have turnovers of only a few days, thus reducing the issue of microalgal grazers.

  4. Comparison of Microalgae Cultivation in Photobioreactor, Open Raceway Pond, and a Two-Stage Hybrid System

    International Nuclear Information System (INIS)

    Narala, Rakesh R.; Garg, Sourabh; Sharma, Kalpesh K.; Thomas-Hall, Skye R.; Deme, Miklos; Li, Yan; Schenk, Peer M.

    2016-01-01

    In the wake of intensive fossil fuel usage and CO 2 accumulation in the environment, research is targeted toward sustainable alternate bioenergy that can suffice the growing need for fuel and also that leaves a minimal carbon footprint. Oil production from microalgae can potentially be carried out more efficiently, leaving a smaller footprint and without competing for arable land or biodiverse landscapes. However, current algae cultivation systems and lipid induction processes must be significantly improved and are threatened by contamination with other algae or algal grazers. To address this issue, we have developed an efficient two-stage cultivation system using the marine microalga Tetraselmis sp. M8. This hybrid system combines exponential biomass production in positive pressure air lift-driven bioreactors with a separate synchronized high-lipid induction phase in nutrient deplete open raceway ponds. A comparison to either bioreactor or open raceway pond cultivation system suggests that this process potentially leads to significantly higher productivity of algal lipids. Nutrients are only added to the closed bioreactors, while open raceway ponds have turnovers of only a few days, thus reducing the issue of microalgal grazers.

  5. A Risk-Based Interval Two-Stage Programming Model for Agricultural System Management under Uncertainty

    Directory of Open Access Journals (Sweden)

    Ye Xu

    2016-01-01

    Full Text Available Nonpoint source (NPS pollution caused by agricultural activities is main reason that water quality in watershed becomes worse, even leading to deterioration. Moreover, pollution control is accompanied with revenue’s fall for agricultural system. How to design and generate a cost-effective and environmentally friendly agricultural production pattern is a critical issue for local managers. In this study, a risk-based interval two-stage programming model (RBITSP was developed. Compared to general ITSP model, significant contribution made by RBITSP model was that it emphasized importance of financial risk under various probabilistic levels, rather than only being concentrated on expected economic benefit, where risk is expressed as the probability of not meeting target profit under each individual scenario realization. This way effectively avoided solutions’ inaccuracy caused by traditional expected objective function and generated a variety of solutions through adjusting weight coefficients, which reflected trade-off between system economy and reliability. A case study of agricultural production management with the Tai Lake watershed was used to demonstrate superiority of proposed model. Obtained results could be a base for designing land-structure adjustment patterns and farmland retirement schemes and realizing balance of system benefit, system-failure risk, and water-body protection.

  6. Comparison of Microalgae Cultivation in Photobioreactor, Open Raceway Pond, and a Two-Stage Hybrid System

    Energy Technology Data Exchange (ETDEWEB)

    Narala, Rakesh R.; Garg, Sourabh; Sharma, Kalpesh K.; Thomas-Hall, Skye R.; Deme, Miklos; Li, Yan; Schenk, Peer M., E-mail: p.schenk@uq.edu.au [Algae Biotechnology Laboratory, School of Agriculture and Food Sciences, The University of Queensland, Brisbane, QLD (Australia)

    2016-08-02

    In the wake of intensive fossil fuel usage and CO{sub 2} accumulation in the environment, research is targeted toward sustainable alternate bioenergy that can suffice the growing need for fuel and also that leaves a minimal carbon footprint. Oil production from microalgae can potentially be carried out more efficiently, leaving a smaller footprint and without competing for arable land or biodiverse landscapes. However, current algae cultivation systems and lipid induction processes must be significantly improved and are threatened by contamination with other algae or algal grazers. To address this issue, we have developed an efficient two-stage cultivation system using the marine microalga Tetraselmis sp. M8. This hybrid system combines exponential biomass production in positive pressure air lift-driven bioreactors with a separate synchronized high-lipid induction phase in nutrient deplete open raceway ponds. A comparison to either bioreactor or open raceway pond cultivation system suggests that this process potentially leads to significantly higher productivity of algal lipids. Nutrients are only added to the closed bioreactors, while open raceway ponds have turnovers of only a few days, thus reducing the issue of microalgal grazers.

  7. Russian and Brazil media systems at the modern stage of mass communication

    Directory of Open Access Journals (Sweden)

    Filippova Viktoria Alexandrovna

    2015-03-01

    Full Text Available The article describes the main characteristics of modern mass communication and media systems in Russia and Brazil. The so-called first-level media - are of elite character, aimed at the ruling classes. They are strengthening their position in the global space and almost are blurring geographical and cultural boundaries. Media audience of the second level is national, they usually focus on the middle and lower segment of the audience, if to divide it by income, education and culture. Informatization and digitalization of media lead to the formation of hybrid media systems, where there is a growing role of new media, in particular, social networks and Twitter. It is important to emphasize that the nature of the social, spiritual and cultural changes caused by informatization, depends not only on information technology, but also on the social conditions of the socioeconomic system where the implemented processes of mass communication are realized. The paper discusses the factors that determine the possibility of functioning of media systems at the present stage: the willingness of the reader to consume information and pay for it by the example of Russia and Brazil, describes the processes of globalization, information technology and digitalization of society and the media. It is presented media preferences and trust in the media in Russia and Brazil in the XXI century, as well as the main indicators of the advertising market in these countries.

  8. Technical and scale efficiency of cassava production system in Delta State, Nigeria: an application of Two-Stage DEA approach

    Directory of Open Access Journals (Sweden)

    Sanzidur Rahman

    2015-05-01

    Full Text Available The present study examines the level of pure technical and scale efficiencies of cassava production system including its sub-processes (that is production and processing stages of 278 cassava farmers/processors from three regions of Delta State, Nigeria by applying Two-Stage Data Envelopment Analysis (DEA approach. Results reveal that pure technical efficiency (PTE is significantly lower at the production stage 0.41 vs 0.55 for the processing stage, but scale efficiency (SE is high at both stages (0.84 and 0.87, implying that productivity can be improved substantially by reallocation of resources and adjusting operation size. The socio-economic determinants exert differential impacts on PTE and SE at each stage. Overall, education, experience and main occupation as farmer significantly improve SE while subsistence pressure reduces it. Extension contact significantly improves SE at the processing stage but reduces PTE and SE overall. Inverse size-PTE and size-SE relationships exist in cassava production system. In other words, large/medium farms are technically and scale inefficient. Gender gap exists in performance. Male farmers are technically efficient at processing stage but scale inefficient overall. Farmers in northern region are technically efficient. Investments in education, extension services and infrastructure are suggested as policy options to improve the cassava sector in Nigeria.

  9. Development of a hybrid safety system: Actuation of the secondary automatic depressurization system at an early stage

    International Nuclear Information System (INIS)

    Nishimoto, Masae; Umezawa, Shigemitsu; Okabe, Kazuharu; Matsuoka, Tsuyoshi

    1996-01-01

    A Hybrid Safety System, which is an optimum combination of active and passive safety systems, has been developed in order to improve the safety, reliability and economic features of the next generation of PWRs. The passive safety systems include Automatic primary Depressurization System (ADS), Secondary Automatic Depressurization System (SADS), advanced accumulators, gravity injection system and so on. In this study the authors have improved the actuation logic of the passive safety systems. The original logic in the previous study actuates ADS at an early stage of an event such as a Loss-of-Coolant Accident (LOCA), and this is followed by the actuation of SADS. In this study they divide SADS into two systems. The first, small SADS, uses small valves corresponding to the relief valves of the conventional PWR plants. The second, large SADS, corresponds to the original SADS using multiple valves of large capacity. With the new logic, the passive systems are actuated during a typical small LOCA. Small LOCA analyses using several break areas were performed for a 1,400 MWe PWR plant with a Hybrid Safety System. The results predict that core uncovery does not occur in the case of a relatively small break area and that core heat removal during a small LOCA is improved in comparison with the analyses for conventional PWR plants, where the secondary pressure remains higher during the event. The results also predict that this new logic make it possible to reduce the ADS valve size and the actuation pressure setpoint of the passive safety systems

  10. Multi-Stage Admission Control for Load Balancing in Next Generation Systems

    DEFF Research Database (Denmark)

    Mihovska, Albena D.; Anggorojati, Bayu; Luo, Jijun

    2008-01-01

    This paper describes a load-dependent multi-stage admission control suitable for next generation systems. The concept uses decision polling in entities located at different levels of the architecture hierarchy and based on the load to activate a sequence of actions related to the admission...... of a user to the network, i.e., the ranking of the intermediate decisions is dynamic. The decision is controlled by passing a token between the base station (BS) and the gateway (GW), thereby considering the load status of the BS and the backhaul network. A token is assigned to the entity with the highest...... load. Each admission request will issue a flag whose colour will reflect the load level in this entity and will determine the correct sequence of the required admission control actions....

  11. Product prioritization in a two-stage food production system with intermediate storage

    DEFF Research Database (Denmark)

    Akkerman, Renzo; van Donk, Dirk Pieter

    2007-01-01

    In the food-processing industry, usually a limited number of storage tanks for intermediate storage is available, which are used for different products. The market sometimes requires extremely short lead times for some products, leading to prioritization of these products, partly through...... the dedication of a storage tank. This type of situation has hardly been investigated, although planners struggle with it in practice. This paper aims at investigating the fundamental effect of prioritization and dedicated storage in a two-stage production system, for various product mixes. We show...... the performance improvements for the prioritized product, as well as the negative effects for the other products. We also show how the effect decreases with more storage tanks, and increases with more products....

  12. Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum.

    Science.gov (United States)

    Chen, Yun; Li, Qian; Wu, Qingsheng

    2014-01-01

    cis-Diamminediiodoplatinum (cis-DIDP) is a cisplatin-like anticancer drug with higher anticancer activity, but lower stability and price than cisplatin. In this study, a cis-DIDP carrier system based on micro-sized stearic acid was prepared by an emulsion solvent evaporation method. The maximum drug loading capacity of cis-DIDP-loaded solid lipid nanoparticles was 22.03%, and their encapsulation efficiency was 97.24%. In vitro drug release in phosphate-buffered saline (pH =7.4) at 37.5°C exhibited a unique two-stage process, which could prove beneficial for patients with tumors and malignancies. MTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay results showed that cis-DIDP released from cis-DIDP-loaded solid lipid nanoparticles had better inhibition activity than cis-DIDP that had not been loaded.

  13. A two-stage optimal planning and design method for combined cooling, heat and power microgrid system

    International Nuclear Information System (INIS)

    Guo, Li; Liu, Wenjian; Cai, Jiejin; Hong, Bowen; Wang, Chengshan

    2013-01-01

    Highlights: • A two-stage optimal method is presented for CCHP microgrid system. • Economic and environmental performance are considered as assessment indicators. • Application case demonstrates its good economic and environmental performance. - Abstract: In this paper, a two-stage optimal planning and design method for combined cooling, heat and power (CCHP) microgrid system was presented. The optimal objective was to simultaneously minimize the total net present cost and carbon dioxide emission in life circle. On the first stage, multi-objective genetic algorithm based on non-dominated sorting genetic algorithm-II (NSGA-II) was applied to solve the optimal design problem including the optimization of equipment type and capacity. On the second stage, mixed-integer linear programming (MILP) algorithm was used to solve the optimal dispatch problem. The approach was applied to a typical CCHP microgrid system in a hospital as a case study, and the effectiveness of the proposed method was verified

  14. {sup 18}F-FDG-PET/CT for systemic staging of newly diagnosed triple-negative breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ulaner, Gary A.; Castillo, Raychel; Riedl, Christopher C.; Jochelson, Maxine S. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Weill Cornell Medical College, Department of Radiology, New York, NY (United States); Goldman, Debra A.; Goenen, Mithat [Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY (United States); Wills, Jonathan [Memorial Sloan Kettering Cancer Center, Department of Information Systems, New York, NY (United States); Pinker-Domenig, Katja [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States)

    2016-10-15

    National Comprehensive Cancer Network guidelines recommend {sup 18}F-FDG-PET/CT, in addition to standard staging procedures, for systemic staging of newly diagnosed stage III breast cancer patients. However, factors in addition to stage may influence PET/CT utility. As breast cancers that are negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor (triple-negative breast cancer, or TNBC) are more aggressive and metastasize earlier than other breast cancers, we hypothesized that receptor expression may be one such factor. This study assesses {sup 18}F-FDG-PET/CT for systemic staging of newly diagnosed TNBC. In this Institutional Review Board-approved retrospective study, our Healthcare Information System was screened for patients with TNBC who underwent {sup 18}F-FDG-PET/CT in 2007-2013 prior to systemic or radiation therapy. Initial stage was determined from mammography, ultrasound, magnetic resonance imaging, and/or surgery, if performed prior to {sup 18}F-FDG-PET/CT. {sup 18}F-FDG-PET/CT was evaluated to identify unsuspected extra-axillary regional nodal and distant metastases, as well as unsuspected synchronous malignancies. Kaplan Meier survival estimates were calculated for initial stage IIB patients stratified by whether or not stage 4 disease was detected by {sup 18}F-FDG-PET/CT. A total of 232 patients with TNBC met inclusion criteria. {sup 18}F-FDG-PET/CT revealed unsuspected distant metastases in 30 (13 %): 0/23 initial stage I, 4/82 (5 %) stage IIA, 13/87 (15 %) stage IIB, 4/23 (17 %) stage IIIA, 8/14 (57 %) stage IIIB, and 1/3 (33 %) stage IIIC. Twenty-six of 30 patients upstaged to IV by {sup 18}F-FDG-PET/CT were confirmed by pathology, with the remaining four patients confirmed by follow-up imaging. In addition, seven unsuspected synchronous malignancies were identified in six patients. Initial stage 2B patients who were upstaged to 4 by {sup 18}F-FDG-PET/CT had significantly shorter survival compared to

  15. METHODOLOGY AND RESULTS OF MOBILE OBJECT PURSUIT PROBLEM SOLUTION WITH TWO-STAGE DYNAMIC SYSTEM

    Directory of Open Access Journals (Sweden)

    A. Kiselev Mikhail

    2017-01-01

    Full Text Available The experience of developing unmanned fighting vehicles indicates that the main challenge in this field reduces itself to creating the systems which can replace the pilot both as a sensor and as the operator of the flight. This problem can be partial- ly solved by introducing remote control, but there are certain flight segments where it can only be executed under fully inde- pendent control and data support due to various reasons, such as tight time, short duration, lack of robust communication, etc. Such stages also include close-range air combat maneuvering (CRACM - a key flight segment as far as the fighter's purpose is concerned, which also places the highest demands on the fighter's design. Until recently the creation of an unmanned fighter airplane has been a fundamentally impossible task due to the absence of sensors able to provide the necessary data support to control the fighter during CRACM. However, the development prospects of aircraft hardware (passive type flush antennae, op- tico-locating panoramic view stations are indicative of producing possible solutions to this problem in the nearest future. There- fore, presently the only fundamental impediment on the way to developing an unmanned fighting aircraft is the problem of cre- ating algorithms for automatic trajectory control during CRACM. This paper presents the strategy of automatic trajectory con- trol synthesis by a two-stage dynamic system aiming to reach the conditions specified with respect to an object in pursuit. It contains certain results of control algorithm parameters impact assessment in regards to the pursuit mission effectiveness. Based on the obtained results a deduction is drawn pertaining to the efficiency of the offered method and its possible utilization in au- tomated control of an unmanned fighting aerial vehicle as well as organizing group interaction during CRACM.

  16. A New Load Residual Threshold Definition for the Evaluation of Wind Tunnel Strain-Gage Balance Data

    Science.gov (United States)

    Ulbrich, N.; Volden, T.

    2016-01-01

    A new definition of a threshold for the detection of load residual outliers of wind tunnel strain-gage balance data was developed. The new threshold is defined as the product between the inverse of the absolute value of the primary gage sensitivity and an empirical limit of the electrical outputs of a strain{gage. The empirical limit of the outputs is either 2.5 microV/V for balance calibration or check load residuals. A reduced limit of 0.5 microV/V is recommended for the evaluation of differences between repeat load points because, by design, the calculation of these differences removes errors in the residuals that are associated with the regression analysis of the data itself. The definition of the new threshold and different methods for the determination of the primary gage sensitivity are discussed. In addition, calibration data of a six-component force balance and a five-component semi-span balance are used to illustrate the application of the proposed new threshold definition to different types of strain{gage balances. During the discussion of the force balance example it is also explained how the estimated maximum expected output of a balance gage can be used to better understand results of the application of the new threshold definition.

  17. An Enhanced Droop Control Scheme for Resilient Active Power Sharing in Paralleled Two-Stage PV Inverter Systems

    DEFF Research Database (Denmark)

    Liu, Hongpeng; Yang, Yongheng; Wang, Xiongfei

    2016-01-01

    generation) due to the intermittency. In that case, unbalance in active power generation may occur among the paralleled systems. Additionally, most droop-controlled systems have been assumed to be a single dc-ac inverter with a fixed dc input source. The dc-dc converter as the front-end of a two......-stage photovoltaic (PV) system has not been considered. In this paper, an enhanced droop scheme is thus proposed to address those issues, and the proposed scheme can enable resilient active power sharing in parallel two-stage PV inverter systems. Furthermore, a small-signal analysis for the proposed droop control...

  18. NASAwide electronic publishing system: Prototype STI electronic document distribution, stage-4 evaluation report

    Science.gov (United States)

    Tuey, Richard C.; Collins, Mary; Caswell, Pamela; Haynes, Bob; Nelson, Michael L.; Holm, Jeanne; Buquo, Lynn; Tingle, Annette; Cooper, Bill; Stiltner, Roy

    1996-01-01

    This evaluation report contains an introduction, seven chapters, and five appendices. The Introduction describes the purpose, conceptual frame work, functional description, and technical report server of the STI Electronic Document Distribution (EDD) project. Chapter 1 documents the results of the prototype STI EDD in actual operation. Chapter 2 documents each NASA center's post processing publication processes. Chapter 3 documents each center's STI software, hardware, and communications configurations. Chapter 7 documents STI EDD policy, practices, and procedures. The appendices, which arc contained in Part 2 of this document, consist of (1) STI EDD Project Plan, (2) Team members, (3) Phasing Schedules, (4) Accessing On-line Reports, and (5) Creating an HTML File and Setting Up an xTRS. In summary, Stage 4 of the NASAwide Electronic Publishing System is the final phase of its implementation through the prototyping and gradual integration of each NASA center's electronic printing systems, desktop publishing systems, and technical report servers to be able to provide to NASA's engineers, researchers, scientists, and external users the widest practicable and appropriate dissemination of information concerning its activities and the result thereof to their work stations.

  19. Flight results of attitude matching between Space Shuttle and Inertial Upper Stage (IUS) navigation systems

    Science.gov (United States)

    Treder, Alfred J.; Meldahl, Keith L.

    The recorded histories of Shuttle/Orbiter attitude and Inertial Upper Stage (IUS) attitude have been analyzed for all joint flights of the IUS in the Orbiter. This database was studied to determine the behavior of relative alignment between the IUS and Shuttle navigation systems. It is found that the overall accuracy of physical alignment has a Shuttle Orbiter bias component less than 5 arcmin/axis and a short-term stability upper bound of 0.5 arcmin/axis, both at 1 sigma. Summaries of the experienced physical and inertial alginment offsets are shown in this paper, together with alignment variation data, illustrated with some flight histories. Also included is a table of candidate values for some error source groups in an Orbiter/IUS attitude errror model. Experience indicates that the Shuttle is much more accurate and stable as an orbiting launch platform than has so far been advertised. This information will be valuable for future Shuttle payloads, especially those (such as the Aeroassisted Flight Experiment) which carry their own inertial navigation systems, and which could update or initialize their attitude determination systems using the Shuttle as the reference.

  20. Value of five-stage prognostic system in predicting short-term outcome of patients with liver cirrhosis

    Directory of Open Access Journals (Sweden)

    TIAN Yan

    2015-03-01

    Full Text Available ObjectiveTo evaluate the clinical value of five-stage prognostic system in predicting the short-term outcome of patients with liver cirrhosis, and to compare it with the Child-Turcotte-Pugh (CTP and Model of End-Stage Liver Disease (MELD scores. MethodsTwo hundred and one hospitalized patients with liver cirrhosis in the Department of Gastroenterology in the First Affiliated Hospital of Anhui Medical University from January 2011 to January 2014 were enrolled in the study and followed up for at least six months. Patients were classified accorded to the five-stage prognostic system, and the mortality rate in each stage was measured. The receiver operating characteristic (ROC curve and the area under the ROC curve (AUC were used to assess the accuracy of the five-stage prognostic system in predicting the short-term death risk of cirrhotic patients, which was then compared with the CTP and MELD scores. Categorical data were analyzed by chi-square test. Comparison of AUC was made by normal distribution Z test. Spearman′s correlation analysis was used to investigate the correlation of the five-stage prognostic system with the CTP and MELD scores. ResultsThe study used the admission time as the starting point and the death of patients or study termination time as the endpoint. Among the 201 patients, 50 (24.9% died within six months. Based on the five-stage prognostic system, the mortality rates for stages 1 to 5 were 0(0/11, 0(0/18, 4.2%(2/48, 16.3% (7/43, and 50.6%(41/81, respectively. In patients with decompensated cirrhosis (stages 3, 4, and 5, the mortality increased with stage, and the differences in mortality between patients in stages 3 and 4, 3 and 5, and 4 and 5 were all significant (χ2=3.89, 35.33, and 13.96, respectively; P=0.049, 0.000, and 0.049, respectively. The AUC for the five-stage prognostic system, five-stage prognostic system combined with CTP and MELD score, and CTP score were 0820, 0.915, 0.888, and 0

  1. OCT Glaucoma Staging System: a new method for retinal nerve fiber layer damage classification using spectral-domain OCT.

    Science.gov (United States)

    Brusini, P

    2018-01-01

    PurposeTo describe a new method, the Optical Coherence Tomography (OCT) Glaucoma Staging System, for classifying retinal nerve fiber layer (RNFL) damage assessed with OCT.Patients and methodsThe OCT Glaucoma Staging System was created based on data obtained from Nidek RS 3000 spectral-domain (sd)-OCT. This system uses the superior and inferior quadrant RNFL thickness values, plotted on an x-y diagram for staging structural damage severity in glaucoma. A non-linear equation and two regression lines describe the boundary lines which separate the different sectors of the diagram. These mathematical formulas have been used to create a software, which provides a quick classification of the RNFL damage. Sensitivity and specificity of the system were assessed in a different cohort including 64 patients with early OAG, and 62 normal subjects.ResultsThree hundred and two OCT tests from 98 healthy controls and 284 patients affected by either ocular hypertension or chronic open-angle glaucoma were considered in order to design the new classification system. The OCT Glaucoma Staging System classifies RNFL defects into 6 stages of increasing severity ranging from borderline to stage 5, and 3 groups according to defect localization (superior, inferior, or diffuse). Sensitivity and specificity in discriminating between healthy and glaucomatous eyes were 95.2 and 91.9%, respectively, considering borderline results as abnormal.ConclusionsThe OCT Glaucoma Staging System appears to provide a standardized and objective classification of glaucomatous RNFL damage. It can be used in day-to-day clinical practice for an easy and fast interpretation of RNFL measurements obtained with OCT.

  2. Different physiological stages and breeding systems related to the variability of meat quality of indigenous Pantaneiro sheep.

    Science.gov (United States)

    Monteschio, Jéssica de Oliveira; Burin, Poliana Campos; Leonardo, Ariadne Patricia; Fausto, Daiane Aparecido; da Silva, Adrielly Lais Alves; Ricardo, Hélio de Almeida; Corrêa da Silva, Marcelo; de Souza, Márcio Rodrigues; de Vargas Junior, Fernando Miranda

    2018-01-01

    This study configures a first report regarding the variability of meat quality of locally adapted Pantaneiro sheep depending on different physiological stages and breeding systems. Pantaneiro sheep are raised in Brazil under a tropical wetland ecosystem denominated Pantanal. Twenty-nine Pantaneiro sheep from different sex and physiological stages were sorted into three groups, simulating three of the most representative ovine meat products commercialized by South American industries: a) non castrated male lambs (n = 11); b) wethers (n = 9); c) cull ewes (n = 9). Animals from each physiological stage were submitted to different breeding systems, resembling farming strategies adopted in several developing countries of South America. The effect of physiological stages on the quality of meat was accessed using 16 variables measured in the longissimus thoracis et lumborum (LM) and the semimembranosus (SM) muscles. The variables were related to brightness, color, physical aspects, soluble and total collagen as well as chemical traits. The physiological stage was defined as a classification variable in order to proceed ANOVA tests and comparison of means (Pmeat quality varies according to different physiological stages, especially between lambs (a) and cull ewes (c). As a consequence, the physiological stage at slaughter should be taken into consideration to cote the quality of meat from indigenous sheep raised in tropical regions. The results contribute towards sensorial evaluation and the characterization of potential food products derived from indigenous sheep bred under tropical climate in developing countries.

  3. Comprehensive study of the intestinal stage of listeriosis in a rat ligated ileal loop system.

    Science.gov (United States)

    Pron, B; Boumaila, C; Jaubert, F; Sarnacki, S; Monnet, J P; Berche, P; Gaillard, J L

    1998-02-01

    The intestinal stage of listeriosis was studied in a rat ligated ileal loop system. Listeria monocytogenes translocated to deep organs with similar efficiencies after inoculation of loops with or without Peyer's patches. Bacterial seeding of deep organs was demonstrated as early as 15 min after inoculation. It was dose dependent and nonspecific, as the delta inlAB, the delta hly, and the delta actA L. monocytogenes mutants and the nonpathogenic species, Listeria innocua, translocated similarly to wild-type L. monocytogenes strains. The levels of uptake of listeriae by Peyer's patches and villous intestine were similar and low, 50 to 250 CFU per cm2 of tissue. No listeria cells crossing the epithelial sheet of Peyer's patches and villous intestine were observed by transmission electron microscopy. The lack of significant interaction of listeriae and the follicle-associated epithelium of Peyer's patches was confirmed by scanning electron microscopy. The follicular tissue of Peyer's patches was a preferential site of Listeria replication. With all doses tested, the rate of bacterial growth was 10 to 20 times higher in Peyer's patches than in villous intestine. At early stages of Peyer's patch infection, listeriae were observed inside mononuclear cells of the dome area. Listeriae then disseminated throughout the follicular tissue except for the germinal center. The virulence determinants hly and, to a lesser extent, actA, but not inlAB, were required for the completion of this process. This study suggests that Peyer's patches are preferential sites for replication rather than for entry of L. monocytogenes, due to the presence of highly permissive mononuclear cells whose nature remains to be defined.

  4. Two-Stage n-PSK Partitioning Carrier Phase Recovery Scheme for Circular mQAM Coherent Optical Systems

    DEFF Research Database (Denmark)

    Rodrigo Navarro, Jaime; Kakkar, Aditya; Pang, Xiaodan

    2016-01-01

    A novel two-stage n-PSK partitioning carrier phase recovery (CPR) scheme for circular multilevel quadrature amplitude modulation (C-mQAM) constellations is presented. The first stage of the algorithm provides an initial rough estimation of the received constellation, which is utilized in the second......-16QAM back-to-back transmission system. The computational complexity of the proposed CPR scheme is studied, and reduction factors of 24.5 | 30.1 and 59.1 | 63.3 are achieved for C-16QAM and C-64QAM, respectively, compared to single-stage BPS in the form of multipliers | adders....

  5. Impact of the End Stage Renal Disease Prospective Payment System on the Use of Peritoneal Dialysis.

    Science.gov (United States)

    Zhang, Qian; Thamer, Mae; Kshirsagar, Onkar; Zhang, Yi

    2017-05-01

    The End Stage Renal Disease (ESRD) Prospective Payment System (PPS), implemented by the Centers for Medicare and Medicaid Services in January 2011, encouraged use of peritoneal dialysis (PD) through various financial incentives. Our goal was to determine whether PPS effectively increased PD use in incident dialysis patients. Our study used the United States Renal Data System (USRDS) to identify 430,927 adult patients who initiated dialysis between 2009 and 2012. The interrupted time series method was used to evaluate the association Centers for Medicare and Medicaid Services of PPS with PD use at dialysis initiation. We further stratified by patient demographics, predialysis care, and facility chain and profit status. Interrupted time series analysis indicated PPS was associated with increased PD use in the 2-year period after PPS (change in slope = 0.04, P  PPS ( P  = 0.512). Stratified analyses indicated PPS led to increased PD use across all age, race, and sex groups ( P  PPS. Our findings highlight the role of financial incentives in changing practice patterns to increase use of a dialysis modality considered to be both more cost-effective and empowering to ESRD patients. However, even after PPS, rates of PD use remain low among the dialysis population in the USA.

  6. Reward, motivation, and emotion systems associated with early-stage intense romantic love.

    Science.gov (United States)

    Aron, Arthur; Fisher, Helen; Mashek, Debra J; Strong, Greg; Li, Haifang; Brown, Lucy L

    2005-07-01

    Early-stage romantic love can induce euphoria, is a cross-cultural phenomenon, and is possibly a developed form of a mammalian drive to pursue preferred mates. It has an important influence on social behaviors that have reproductive and genetic consequences. To determine which reward and motivation systems may be involved, we used functional magnetic resonance imaging and studied 10 women and 7 men who were intensely "in love" from 1 to 17 mo. Participants alternately viewed a photograph of their beloved and a photograph of a familiar individual, interspersed with a distraction-attention task. Group activation specific to the beloved under the two control conditions occurred in dopamine-rich areas associated with mammalian reward and motivation, namely the right ventral tegmental area and the right postero-dorsal body and medial caudate nucleus. Activation in the left ventral tegmental area was correlated with facial attractiveness scores. Activation in the right anteromedial caudate was correlated with questionnaire scores that quantified intensity of romantic passion. In the left insula-putamen-globus pallidus, activation correlated with trait affect intensity. The results suggest that romantic love uses subcortical reward and motivation systems to focus on a specific individual, that limbic cortical regions process individual emotion factors, and that there is localization heterogeneity for reward functions in the human brain.

  7. Computer-Assisted Decision Support System in Pulmonary Cancer detection and stage classification on CT images.

    Science.gov (United States)

    Masood, Anum; Sheng, Bin; Li, Ping; Hou, Xuhong; Wei, Xiaoer; Qin, Jing; Feng, Dagan

    2018-03-01

    Pulmonary cancer is considered as one of the major causes of death worldwide. For the detection of lung cancer, computer-assisted diagnosis (CADx) systems have been designed. Internet-of-Things (IoT) has enabled ubiquitous internet access to biomedical datasets and techniques; in result, the progress in CADx is significant. Unlike the conventional CADx, deep learning techniques have the basic advantage of an automatic exploitation feature as they have the ability to learn mid and high level image representations. We proposed a Computer-Assisted Decision Support System in Pulmonary Cancer by using the novel deep learning based model and metastasis information obtained from MBAN (Medical Body Area Network). The proposed model, DFCNet, is based on the deep fully convolutional neural network (FCNN) which is used for classification of each detected pulmonary nodule into four lung cancer stages. The performance of proposed work is evaluated on different datasets with varying scan conditions. Comparison of proposed classifier is done with the existing CNN techniques. Overall accuracy of CNN and DFCNet was 77.6% and 84.58%, respectively. Experimental results illustrate the effectiveness of proposed method for the detection and classification of lung cancer nodules. These results demonstrate the potential for the proposed technique in helping the radiologists in improving nodule detection accuracy with efficiency. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. Diagnostic value of computed tomography in the colon cancer; In terms of the staging system

    International Nuclear Information System (INIS)

    Lee, Joo Mi; Moon, Jang Ho; Lee, Dong Joong; Choi, Chul Soon; Kang, Ik Won; Chung, Soo Young; Bae, Sang Hoon; Yoon, Jong Sub

    1989-01-01

    The CT findings of thirty-three patients with proven colon cancer were analysed. The results were as follows; 1. The accuracy for detecting pericolic fat invasion on CT was 81%. 2. The accuracy for detecting lymph node involvement on CT was 67%. 3. The overall accuracy for staging of colon cancer on CT was 64%(67% for stage A, 30% for stage B, 60% for stage C, 100% for stage D). 4. The overall detection rate of mass on CT was 80%(89% for rectum, 100% for rectosigmoid colon and sigmoid colon, 30% for ascending and transverse colon). 5. The CT is useful, noninvasive technique for assessing extension and staging of colon cancer

  9. Performance analysis of a single stage four bed metal hydride cooling system, part A: Influence of mass recovery

    Energy Technology Data Exchange (ETDEWEB)

    Abraham, Kevin; Prakash Maiya, M.; Srinivasa Murthy, S. [Refrigeration and Air-conditioning Laboratory, Department of Mechanical Engineering, Indian Institute of Technology Madras, 600036, Chennai (India)

    2003-01-01

    The concept of mass recovery in metal hydride systems is studied with a single stage multi-bed cooling system as example. Mass recovery results in variation of bed temperatures due to removal or addition of heat of desorption or absorption respectively. Coefficient of performance and cold output increase while required heat input decreases for the mass recovery cycle. Thus mass recovery between hydride reactors is found to improve system performance compared to that of a basic system. (authors)

  10. UVC-induced lysis and detritus production of Oscillatoria limnetica in a two-stage continuous-flow system

    NARCIS (Netherlands)

    Van Hannen, E.J.; Gons, H.J.

    1997-01-01

    In order to study in model systems the role of heterotrophic micro-organisms in the aquatic microbial food web, a natural food source consisting of senescent primary producer cells is indispensable. A two-stage continuous-flow system with the ability to produce detritus continuously is presented. In

  11. NSVS 7051868: A system in a key evolutionary stage. First multi-color photometric study

    Science.gov (United States)

    Barani, C.; Martignoni, M.; Acerbi, F.

    2017-01-01

    The first CCD photometric complete light curves of the eclipsing binary NSVS 7051868 were obtained during six nights in January 2016 in the B, V and Ic bands using the 0.25 m telescope of the Stazione Astronomica Betelgeuse in Magnago, Italy. These observations confirm the short period (P = 0.517 days) variation found by Shaw and collaborators in their online list (http://www.physast.uga.edu/ jss/nsvs/) of periodic variable stars found in the Northern Sky Variability Survey. The light curves were modelled using the Wilson-Devinney code and the elements obtained from this analysis are used to compute the physical parameters of the system in order to study its evolutionary status. A grid of solutions for several fixed values of mass ratio was calculated. A reasonable fit of the synthetic light curves of the data indicate that NSVS 7051868 is an A-subtype W Ursae Majoris contact binary system, with a low mass ratio of q = 0.22, a degree of contact factor f = 35.5% and inclination i = 85°. Our light curves shows a time of constant light in the secondary eclipse of approximately 0.1 in phase. The light curve solution reveals a component temperature difference of about 700 K. Both the value of the fill-out factor and the temperature difference suggests that NSVS 7051868 is a system in a key evolutionary stage of the Thermal Relaxation Oscillation theory. The distance to NSVS 7051868 was calculated as 180 pc from this analysis, taking into account interstellar extinction.

  12. State Space System Identification of 3-Degree-of-Freedom (DOF Piezo-Actuator-Driven Stages with Unknown Configuration

    Directory of Open Access Journals (Sweden)

    Yu Cao

    2013-03-01

    Full Text Available Due to their fast response, high accuracy and non-friction force, piezo-actuators have been widely employed in multiple degree-of-freedom (DOF stages for various nano-positioning applications. The use of flexible hinges in these piezo-actuator-driven stages allows the elimination of the influence of friction and backlash clearance, as observed in other configurations; meanwhile it also causes more complicated stage performance in terms of dynamics and the cross-coupling effect between different axes. Based on the system identification technique, this paper presents the development of a model for the 3-DOF piezo-actuator-driven stages with unknown configuration, with its parameters estimated from the Hankel matrix by means of the maximum a posteriori (MAP online estimation. Experiments were carried out on a commercially-available piezo-actuator-driven stage to verify the effectiveness of the developed model, as compared to other methods. The results show that the developed model is able to predict the stage performance with improved accuracy, while the model parameters can be well updated online by using the MAP estimation. These capabilities allow investigation of the complicated stage performance and also provide a starting point from which the mode-based control scheme can be established for improved performance.

  13. A two-phase inspection model for a single component system with three-stage degradation

    International Nuclear Information System (INIS)

    Wang, Huiying; Wang, Wenbin; Peng, Rui

    2017-01-01

    This paper presents a two-phase inspection schedule and an age-based replacement policy for a single plant item contingent on a three-stage degradation process. The two phase inspection schedule can be observed in practice. The three stages are defined as the normal working stage, low-grade defective stage and critical defective stage. When an inspection detects that an item is in the low-grade defective stage, we may delay the preventive replacement action if the time to the age-based replacement is less than or equal to a threshold level. However, if it is above this threshold level, the item will be replaced immediately. If the item is found in the critical defective stage, it is replaced immediately. A hybrid bee colony algorithm is developed to find the optimal solution for the proposed model which has multiple decision variables. A numerical example is conducted to show the efficiency of this algorithm, and simulations are conducted to verify the correctness of the model. - Highlights: • A two-phase inspection model is studied. • The failure process has three stages. • The delayed replacement is considered.

  14. Embryonic staging system for the Black Mastiff Bat, Molossus rufus (Molossidae), correlated with structure-function relationships in the adult.

    Science.gov (United States)

    Nolte, Mark J; Hockman, Dorit; Cretekos, Chris J; Behringer, Richard R; Rasweiler, John J

    2009-02-01

    An embryonic staging system for Molossus rufus (also widely known as Molossus ater) was devised using 17 reference specimens obtained during the postimplantation period of pregnancy from wild-caught, captive-bred females. This was done in part by comparing the embryos to a developmental staging system that had been created for another, relatively unrelated bat, Carollia perspicillata (family Phyllostomidae). Particular attention was paid to the development of species-specific features, such as wing and ear morphology, and these are discussed in light of the adaptive significance of these structures in the adult. M. rufus can be maintained and bred in captivity and is relatively abundant in the wild. This embryonic staging system will facilitate further developmental studies of M. rufus, a model species for one of the largest and most successful chiropteran families, the Molossidae. (c) 2008 Wiley-Liss, Inc.

  15. Respiratory behavior of turning stage mature tomato (Solanum lycopersicum L. under closed system at different temperature

    Directory of Open Access Journals (Sweden)

    Ranjeet Singh

    2013-01-01

    Full Text Available The respiration rate and respiratory quotient of mature tomato (Solanum lycopersicum L. cv. ‘Himsona’ fruits harvested at the turning stage were determined under closed system at 5, 10, 15, 20, 25 and 35 °C (ambient temperatures. The rate of respiration was higher at the start of the experiment and gradually declined as the storage period prolonged, before becoming almost constant. The steady-state respiration rate for CO2 evolution were observed to be 14.35, 15.04,19.95, 21.7 and 20.3 ml/kg-h at 10 °C, 15 °C, 20 °C, 25 °C and 35 °C, respectively. The RQ values for tomato varied from 0.55 to 1.10 with time under the experimental conditions. The respiration rate at steady state based on carbon dioxide evolution and oxygen consumption in closed condition decreased by about 46 % and 73 %, respectively relative to initial respiration rate values at normal air atmosphere. The results suggest that the respiration rate of tomato increased with temperature and decrease with storage time.

  16. Vacuumed gap membrane distillation (vagmed) module, multi-stage vagmed systems, and vagmed processes

    KAUST Repository

    Ghaffour, Noreddine

    2016-06-30

    Vacuumed gap membrane distillation (VAGMED) modules, and multi-stage VAGMED systems and processes using the modules are provided. In an embodiment, the membrane distillation modules (10) can comprise: a) a condenser (12) including a condensation surface (15); b) a first passageway (13) having an inlet for receiving a first feed stream (14) and an outlet through which the first stream can pass out of the first passageway, the first passageway configured to bring the first feed stream into thermal communication with the condensation surface; c) an evaporator (17) including a permeable evaporation surface allowing condensable gas to pass there through; d) a second passageway (18) having an inlet for receiving a second feed stream (19) and an outlet through which the second feed stream can pass out of the second passageway, the second passageway configured to bring the second feed stream into communication with the permeable evaporation surface; and e) an enclosure (24) providing a vacuum compartment within which the condenser, the evaporator and the first and second passageways of the module are contained.

  17. Extinction and permanence in delayed stage-structure predator-prey system with impulsive effects

    International Nuclear Information System (INIS)

    Pang Guoping; Wang Fengyan; Chen Lansun

    2009-01-01

    Based on the classical stage-structured model and Lotka-Volterra predator-prey model, an impulsive delayed differential equation to model the process of periodically releasing natural enemies at fixed times for pest control is proposed and investigated. We show that the conditions for global attractivity of the 'pest-extinction' ('prey-eradication') periodic solution and permanence of the population of the model depend on time delay. We also show that constant maturation time delay and impulsive releasing for the predator can bring great effects on the dynamics of system by numerical analysis. As a result, the pest maturation time delay is considered to establish a procedure to maintain the pests at an acceptably low level in the long term. In this paper, the main feature is that we introduce time delay and pulse into the predator-prey (natural enemy-pest) model with age structure, exhibit a new modelling method which is applied to investigate impulsive delay differential equations, and give some reasonable suggestions for pest management.

  18. Mathematical modelling of the maternal cardiovascular system in the three stages of pregnancy.

    Science.gov (United States)

    Corsini, Chiara; Cervi, Elena; Migliavacca, Francesco; Schievano, Silvia; Hsia, Tain-Yen; Pennati, Giancarlo

    2017-09-01

    In this study, a mathematical model of the female circulation during pregnancy is presented in order to investigate the hemodynamic response to the cardiovascular changes associated with each trimester of pregnancy. First, a preliminary lumped parameter model of the circulation of a non-pregnant female was developed, including the heart, the systemic circulation with a specific block for the uterine district and the pulmonary circulation. The model was first tested at rest; then heart rate and vascular resistances were individually varied to verify the correct response to parameter alterations characterising pregnancy. In order to simulate hemodynamics during pregnancy at each trimester, the main changes applied to the model consisted in reducing vascular resistances, and simultaneously increasing heart rate and ventricular wall volumes. Overall, reasonable agreement was found between model outputs and in vivo data, with the trends of the cardiac hemodynamic quantities suggesting correct response of the heart model throughout pregnancy. Results were reported for uterine hemodynamics, with flow tracings resembling typical Doppler velocity waveforms at each stage, including pulsatility indexes. Such a model may be used to explore the changes that happen during pregnancy in female with cardiovascular diseases. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  19. Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum

    Directory of Open Access Journals (Sweden)

    Chen Y

    2014-06-01

    Full Text Available Yun Chen,1,* Qian Li,1,2,* Qingsheng Wu1 1Department of Chemistry, Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai; 2Shanghai Institute of Quality Inspection and Technical Research, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: cis-Diamminediiodoplatinum (cis-DIDP is a cisplatin-like anticancer drug with higher anticancer activity, but lower stability and price than cisplatin. In this study, a cis-DIDP carrier system based on micro-sized stearic acid was prepared by an emulsion solvent evaporation method. The maximum drug loading capacity of cis-DIDP-loaded solid lipid nanoparticles was 22.03%, and their encapsulation efficiency was 97.24%. In vitro drug release in phosphate-buffered saline (pH =7.4 at 37.5°C exhibited a unique two-stage process, which could prove beneficial for patients with tumors and malignancies. MTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide assay results showed that cis-DIDP released from cis-DIDP-loaded solid lipid nanoparticles had better inhibition activity than cis-DIDP that had not been loaded. Keywords: stearic acid, emulsion solvent evaporation method, drug delivery, cis-DIDP, in vitro

  20. Optimization of the method of stages through genetic algorithms for unavailable protection systems analysis considering aging effects

    International Nuclear Information System (INIS)

    Nunes, Marcos Eduardo Costa

    2001-03-01

    When a safety system is under aging the failure times follow non-exponential distributions, and its interstate transition rates become time-dependent. It follows, therefore, that the stochastic process employed in the modeling becomes Nonmarkovian. In this thesis, this analysis is developed using an alternative method, called the device of stages which allows the transformation of Nonmarkovian models into equivalent Markovian ones. That transformation consists in reshaping the state transition diagram with time-dependent transition rates into a new one where fictitious states (called stages) are added and whose transition rates are constant. The number of added stages and their connections are identification parameters of the device of stages used for the equivalent Markovian model and requires a robust and efficient optimization tool. In order to perform a global search in such a topologically complex space, a genetic algorithm has been developed to automatically determine the stages combination and set of parameters which better represent the analyzed distribution. The developed genetic algorithm has demonstrated a good ability for optimizing the method of stages. Results concerning the application to a nuclear reactor protection system are shown and commented, in which the Weibull distribution is employed for modelling failure times. (author)

  1. An adaptive three-stage extended Kalman filter for nonlinear discrete-time system in presence of unknown inputs.

    Science.gov (United States)

    Xiao, Mengli; Zhang, Yongbo; Wang, Zhihua; Fu, Huimin

    2018-04-01

    Considering the performances of conventional Kalman filter may seriously degrade when it suffers stochastic faults and unknown input, which is very common in engineering problems, a new type of adaptive three-stage extended Kalman filter (AThSEKF) is proposed to solve state and fault estimation in nonlinear discrete-time system under these conditions. The three-stage UV transformation and adaptive forgetting factor are introduced for derivation, and by comparing with the adaptive augmented state extended Kalman filter, it is proven to be uniformly asymptotically stable. Furthermore, the adaptive three-stage extended Kalman filter is applied to a two-dimensional radar tracking scenario to illustrate the effect, and the performance is compared with that of conventional three stage extended Kalman filter (ThSEKF) and the adaptive two-stage extended Kalman filter (ATEKF). The results show that the adaptive three-stage extended Kalman filter is more effective than these two filters when facing the nonlinear discrete-time systems with information of unknown inputs not perfectly known. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

  2. Illumination uniformity issue explored via two-stage solar concentrator system based on Fresnel lens and compound flat concentrator

    International Nuclear Information System (INIS)

    Yeh, Naichia

    2016-01-01

    This paper illustrates details about the solar radiation distribution on the target of a two-stage solar concentrator that combines the Fresnel lens (FL) and the compound flat concentrator (CFC). The paper starts with a review of some FL development milestones such as the two-stage systems and the comparisons of flat vs. curved lenses in addition to the most noteworthy FL-based solar energy application, concentration photovoltaic (CPV). Through the review of the FL based CPV and two-stage concentrators, this study leads to the development of an algorithm to explore the spectrum distribution insight on the receiver of a two-stage (FL plus CFC) solar concentration system. It established the potential for using a correctly positioned 2nd stage reflector of right dimension to selectively redirect the desired spectrum on the target area so as to enhance the concentration flux intensity and uniformity at the same time. The study also helped to chart out the approximate locations of certain spectrum segments on the FL's target area, which is useful for exploring the spectrum control mechanism via the Fresnel lenses. - Highlights: • Map out the approximate locations of spectrum segments on FL's focal area. • Use the 2nd stage reflector to selectively reflect the desired spectrum on target. • Explore the spectrum distribution insight on FL solar concentrators' target area.

  3. Experimental study of a staged combustion system for stationary gas turbine applications

    Science.gov (United States)

    Lamont, Warren G.

    Two optically accessible experimental test rigs were designed and constructed to investigate a staged or distributed combustion system for stationary gas turbine applications. The test rigs were fuelled with natural gas and featured two combustion zones: the main combustion zone (MCZ) and the secondary combustion zone (SCZ). The MCZ is a swirl stabilized dump combustor and the SCZ, which is axially downstream from the MCZ, is formed by a transverse jet injecting a premixed fuel/air mixture into the vitiated stream. After installing and commissioning the test rig, an emission survey was conducted to investigate the SCZ conditions, equivalence ratio and momentum ratio, that produce low NOx emissions and give a higher temperature rise before a simulated high pressure turbine than firing only the MCZ. The emission survey found several operating conditions that show the benefit of combustion staging. These beneficial conditions had an SCZ equivalence ratio between 0.41 and 1.12. The data from the emission survey was then used to create an artificial neural network (ANN). The ANN used a multi-layer feed-forward network architecture and was trained with experimental data using the backpropagation training algorithm. The ANN was then used to create performance maps and optimum operational regions were sought. Lastly, optical diagnostics were used to obtain information on the nature of the SCZ reactive jet. The diagnostics included high speed CH* chemiluminescence, OH planar laser induced fluorescence (PLIF) and dual-pump coherent anti-Stokes Raman scattering (CARS). The chemiluminescence and PLIF were used to qualitatively determine the size and shape of the transverse jet reaction zone. Dual-pump CARS was used to quantitatively determine the temperature and H2/N2 concentration ratio profile at the mid-plane of the transverse jet. Dual-pump CARS data was collected for four operating conditions but only one is presented in this dissertation. For the condition presented, the

  4. Characteristics and survival of patients with end stage renal disease and spina bifida in the United States renal data system.

    Science.gov (United States)

    Ouyang, Lijing; Bolen, Julie; Valdez, Rodolfo; Joseph, David; Baum, Michelle A; Thibadeau, Judy

    2015-02-01

    We describe the characteristics, treatments and survival of patients with spina bifida in whom end stage renal disease developed from 2004 through 2008 in the United States Renal Data System. We used ICD-9-CM code 741.* to identify individuals with spina bifida using hospital inpatient data from 1977 to 2010, and physician and facility claims from 2004 to 2008. We constructed a 5:1 comparison group of patients with end stage renal disease without spina bifida matched by age at first end stage renal disease service, gender and race/ethnicity. We assessed the risk of mortality and of renal transplantation while on dialysis using multivariate cause specific proportional hazards survival analysis. We also compared survival after the first renal transplant from the first end stage renal disease service to August 2011. We identified 439 patients with end stage renal disease and spina bifida in whom end stage renal disease developed at an average younger age than in patients without spina bifida (41 vs 62 years, p spina bifida those who had spina bifida showed a similar mortality hazard on dialysis and after transplantation. However, patients with end stage renal disease without spina bifida were more likely to undergo renal transplantation than patients with spina bifida (HR 1.51, 95% CI 1.13-2.03). Hospitalizations related to urinary tract infections were positively associated with the risk of death on dialysis in patients with end stage renal disease and spina bifida (HR 1.42, 95% CI 1.33-1.53). Spina bifida was not associated with increased mortality in patients with end stage renal disease on dialysis or after renal transplantation. Proper urological and bladder management is imperative in patients with spina bifida, particularly in adults. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  5. Different physiological stages and breeding systems related to the variability of meat quality of indigenous Pantaneiro sheep.

    Directory of Open Access Journals (Sweden)

    Jéssica de Oliveira Monteschio

    Full Text Available This study configures a first report regarding the variability of meat quality of locally adapted Pantaneiro sheep depending on different physiological stages and breeding systems. Pantaneiro sheep are raised in Brazil under a tropical wetland ecosystem denominated Pantanal. Twenty-nine Pantaneiro sheep from different sex and physiological stages were sorted into three groups, simulating three of the most representative ovine meat products commercialized by South American industries: a non castrated male lambs (n = 11; b wethers (n = 9; c cull ewes (n = 9. Animals from each physiological stage were submitted to different breeding systems, resembling farming strategies adopted in several developing countries of South America. The effect of physiological stages on the quality of meat was accessed using 16 variables measured in the longissimus thoracis et lumborum (LM and the semimembranosus (SM muscles. The variables were related to brightness, color, physical aspects, soluble and total collagen as well as chemical traits. The physiological stage was defined as a classification variable in order to proceed ANOVA tests and comparison of means (P<0.05. Multivariate analysis was used to identify patterns of similarity and differentiation between samples of different physiological stages (a, b, c. The results revealed that meat quality varies according to different physiological stages, especially between lambs (a and cull ewes (c. As a consequence, the physiological stage at slaughter should be taken into consideration to cote the quality of meat from indigenous sheep raised in tropical regions. The results contribute towards sensorial evaluation and the characterization of potential food products derived from indigenous sheep bred under tropical climate in developing countries.

  6. A translating stage system for µ-PIV measurements surrounding the tip of a migrating semi-infinite bubble.

    Science.gov (United States)

    Smith, B J; Yamaguchi, E; Gaver, D P

    2010-01-01

    We have designed, fabricated and evaluated a novel translating stage system (TSS) that augments a conventional micro particle image velocimetry (µ-PIV) system. The TSS has been used to enhance the ability to measure flow fields surrounding the tip of a migrating semi-infinite bubble in a glass capillary tube under both steady and pulsatile reopening conditions. With conventional µ-PIV systems, observations near the bubble tip are challenging because the forward progress of the bubble rapidly sweeps the air-liquid interface across the microscopic field of view. The translating stage mechanically cancels the mean bubble tip velocity, keeping the interface within the microscope field of view and providing a tenfold increase in data collection efficiency compared to fixed-stage techniques. This dramatic improvement allows nearly continuous observation of the flow field over long propagation distances. A large (136-frame) ensemble-averaged velocity field recorded with the TSS near the tip of a steadily migrating bubble is shown to compare well with fixed-stage results under identical flow conditions. Use of the TSS allows the ensemble-averaged measurement of pulsatile bubble propagation flow fields, which would be practically impossible using conventional fixed-stage techniques. We demonstrate our ability to analyze these time-dependent two-phase flows using the ensemble-averaged flow field at four points in the oscillatory cycle.

  7. Performance evaluation of a once-through multi-stage flash distillation system: Impact of brine heater fouling

    International Nuclear Information System (INIS)

    Baig, Hasan; Antar, Mohamed A.; Zubair, Syed M.

    2011-01-01

    Multi-stage flash distillation (MSF) system modeling involves a number of process variables. An estimation of all these process variables requires both analytical solutions and experimental/field analysis. However, the accurate estimate of variables related to the brine heater operation in a MSF system is very important for a reliable operation of the system. For example, steam operating conditions as well as the brine properties including fouling of the brine heater tubes have a significant effect on the heat transfer characteristics of the brine heater, which in turn influence the distillate output from the system. In this study, the effect of various design as well as operating conditions on the performance ratio (PR), brine temperature and salinity as it leaves the last flash stage are investigated in a once-through system. Increasing the number of stages from 24 to 32 has a significant effect on the PR, it ranges between 79% (for ΔT = 1.5) and 327% (for ΔT = 2.3) for a top-brine temperature of 106 o C. This value increase as the top-brine temperature increases. Increasing the stage-to-stage temperature difference increases the water salinity as it leaves the final stage and reduces its temperature that would imply better energy utilization within the plant. Results show that brine side heat exchanger fouling has a significant effect in decreasing the overall heat transfer coefficient, which reduces the production rate as the fouling increases with time. A sensitivity analysis to identify the key parameters, which can have a significant influence on the desalination plant performance, is carried out in an attempt to contribute a better understanding and operation of MSF desalination processes.

  8. Using a Two-Stage System Evaluation Approach to Explore the New Adoption of an Information System in the Mobile Era

    Science.gov (United States)

    Chen, Ruey-Shin; Liu, I-Fan

    2017-01-01

    Currently, e-learning systems are being widely used in all stages of education. However, it is difficult for school administrators to accurately assess the actual usage performance of a new system, especially when an organization wishes to update the system for users from different backgrounds using new devices such as smartphones. To allow school…

  9. Assessment of capabilities in persons with advanced stage of dementia: Validation of The Montessori Assessment System (MAS).

    Science.gov (United States)

    Erkes, Jérôme; Camp, Cameron J; Raffard, Stéphane; Gély-Nargeot And, Marie-Christine; Bayard, Sophie

    2017-01-01

    This study evaluated the validity and reliability of the Montessori Assessment System. The Montessori Assessment System assesses preserved abilities in persons with moderate to severe dementia. In this respect, this instrument provides crucial information for the development of effective person-centered care plans. A total of 196 persons with a diagnosis of dementia in the moderate to severe stages of dementia were recruited in 10 long-term care facilities in France. All participants completed the Montessori Assessment System, the Clinical Dementia Rating Scale and/or the Mini Mental State Examination and the Severe Impairment Battery-short form. The internal consistency and temporal stability of the Montessori Assessment System were high. Additionally, good construct and divergent validity were demonstrated. Factor analysis showed a one-factor structure. The Montessori Assessment System demonstrated satisfactory psychometric properties while being a useful instrument to assess capabilities in persons with advanced stages of dementia and hence to develop person-centered plans of care.

  10. MAGE, BAGE and GAGE: tumour antigen expression in benign and malignant ovarian tissue.

    Science.gov (United States)

    Gillespie, A M; Rodgers, S; Wilson, A P; Tidy, J; Rees, R C; Coleman, R E; Murray, A K

    1998-09-01

    To determine if ovarian cancer patients would be suitable for MAGE-peptide vaccine-based immunotherapy, the frequency of expression of the MAGE-1-4 genes in ovarian tumours was assessed using reverse transcription polymerase chain reaction (RT-PCR) and product verification with digoxigenin-labelled oligonucleotide probes specific for each MAGE gene. In addition, the frequency of expression of more recently discovered tumour antigens (BAGE, GAGE -1, -2 and GAGE -3, -6) was established using RT-PCR and ethidium bromide staining. In this study 1/16 normal ovarian tissue specimens and 11/25 benign lesions expressed MAGE-1. In non-malignant tissue there was preferential expression of MAGE-1 in premenopausal women. A total of 15/27 malignant specimens expressed MAGE-1, including 10/14 serous cystadenocarcinomas. Expression of other tumour antigens was infrequent. The finding of MAGE-1 expression in both benign and malignant tissue questions previous assumptions regarding the role of MAGE genes in carcinogenesis. In addition, preferential MAGE-1 gene expression in non-malignant premenopausal tissue suggests that the MAGE genes may be involved in cellular proliferation as opposed to carcinogenesis or possibly that MAGE gene expression is under cyclical hormonal control. Finally, this study indicates that serous cystadenocarcinomas may be suitable tumours for MAGE-1 peptide immunotherapy.

  11. Optimization of protection and calibration of the moisture-density gages troxler

    International Nuclear Information System (INIS)

    RAKOTONDRAVANONA, J.E.

    2011-01-01

    The purpose of this work is the implementation of the principle of optimization of the protection and calibration of moisture-density gages TROXLER. The main objectives are the application of radiation protection and the feasibility of a calibration laboratory design. The calibration of density and moisture may confirm the calibration of moisture-density gages TROXLER. The calibration of density consists of the assembly of measurements on three calibration blocks (magnesium, aluminium and magnesium/aluminium) built in the TRACKER. The value of density uncertainty is ±32 Kg.m -3 . The calibration of moisture is carried out on two calibration blocks (magnesium and magnesium/polyethylene)The value of moisture uncertainty is ±16 Kg.m -3 . The design of the laboratory returns to the dose limitation. The laboratory is designed mainly wall out of ordinary concrete, a good attenuator of the gamma radiations and neutron. For the design, the value of term source gamma is 25.77±0.20μSv.h -1 and the value of term source neutron is 7.88±0.35μSv.h -1 are used for the thickness of the walls. The importance of the design makes it possible to attenuate to the maximum doses and rates dose until the total absorption of the radiations. [fr

  12. Comparison of different lymph node staging systems in prognosis of gastric cancer: a bi-institutional study from Hungary.

    Science.gov (United States)

    Tóth, Dezső; Bíró, Adrienn; Varga, Zsolt; Török, Miklós; Árkosy, Péter

    2017-08-01

    The Union for International Cancer Control (UICC) Node (N) classification is the most common used staging method for the prognosis of gastric cancer. It demands adequate, at least 16 lymph nodes (LNs) to be dissected; therefore different staging systems were invented. Between March 2005 and March 2010, 164 patients were evaluated at the Department of General Surgery in the Kenézy Gyula Hospital and at the Department of General, Thoracic and Vascular Surgery in the Kaposi Mór Hospital. The 6th, 7th and 8th UICC N-staging systems, the number of examined LNs, the number of harvested negative LNs, the metastatic lymph node ratio (MLR) and the log odds of positive LNs (LODDS) were determined to measure their 5-year survival rates and to compare them to each other. The overall 5-year survival rate for all patients was 55.5% with a median overall survival time of 102 months. The tumor stage, gender, UICC N-stages, MLR and the LODDS were significant prognostic factors for the 5-year survival with univariate analysis. The 6th UICC N-stage did not follow the adequate risk in comparing N2 vs . N0 and N3 vs . N0 with multivariate investigation. Comparison of performances of the residual N classifications proved that the LODDS system was first in the prediction of prognosis during the evaluation of all patients and in cases with less than 16 harvested LNs. The MLR gave the best prognostic prediction when adequate (more than or equal to 16) lymphadenectomy was performed. We suggest the application of LODDS system routinely in western patients and the usage of MLR classification in cases with extended lymphadenectomy.

  13. Evaluation of the WHO 2010 grading and AJCC/UICC staging systems in prognostic behavior of intestinal neuroendocrine tumors.

    Directory of Open Access Journals (Sweden)

    Paula B Araujo

    Full Text Available BACKGROUND: The increasing incidence and heterogeneous behavior of intestinal neuroendocrine tumors (iNETs pose a clinicopathological challenge. Our goal was to decribe the prognostic value of the new WHO 2010 grading and the AJCC/UICC TNM staging systems for iNETs. Moreover, outcomes of patients treated with somatostatin analogs were assessed. METHODS: We collected epidemiological and clinicopathological data from 93 patients with histologically proven iNETs including progression and survival outcomes. The WHO 2010 grading and the AJCC/UICC TNM staging systems were applied for all cases. RECIST criteria were used to define progression. Kaplan-Meier analyses for progression free survival (PFS and overall survival (OS were performed. RESULTS: Mean follow-up was 58.6 months (4-213 months. WHO 2010 grading yielded PFS and disease-specific OS of 125.0 and 165.8 months for grade 1 (G1, 100.0 and 144.2 months for G2 and 15.0 and 15.8 months for G3 tumors (p = 0.004 and p = 0.001. Using AJCC staging, patients with stage I and II tumors had no progression and no deaths. Stage III and IV patients demonstrated PFS of 138.4 and 84.7 months (p = 0.003 and disease-specific OS of 210.0 and 112.8 months (p = 0.017. AJCC staging also provided informative PFS (91.2 vs. 50.0 months, p = 0.004 and OS (112.3 vs. 80.0 months, p = 0.005 measures with somatostatin analog use in stage IV patients. CONCLUSION: Our findings underscore the complementarity of WHO 2010 and AJCC classifications in providing better estimates of iNETS disease outcomes and extend the evidence for somatostatin analog benefit in patients with metastatic disease.

  14. Problems in use and security of measurement of high temperature strain gages at various temperature limits up to 10000C

    International Nuclear Information System (INIS)

    Ziegler, K.

    1982-01-01

    The examples given show the quality and use of manufacturers' data for a series of behaviour criteria for strain gages in the high temperature region. These results should not only be regarded critically. The manufacturer must appreciate that the very costly programme of investigations on the users' side represents a product development for large parts for the manufacturer of the strain gauges. It would therefore be desirable if these considerations were to initiate investigations on the manufacturer's part, in order to clear up the problematic are of the use of strain gages in the high temperature field, in order to provide the customer with more reliable and better strain gage characteristics for very expensive high temperature strain measurements. (orig.) [de

  15. Excitatory and inhibitory synaptic mechanisms at the first stage of integration in the electroreception system of the shark

    DEFF Research Database (Denmark)

    Rotem, Naama; Sestieri, Emanuel; Hounsgaard, Jørn Dybkjær

    2014-01-01

    , the afferent nerve originating from the ampullae of Lorenzini targets specific neurons located at the Dorsal Octavolateral Nucleus (DON), the first stage of integration in the electroreception system. Using intracellular recordings in an isolated brainstem preparation from the shark we analyze the properties...

  16. Alterations in CD200-CD200R1 System during EAE Already Manifest at Presymptomatic Stages

    Directory of Open Access Journals (Sweden)

    Tony Valente

    2017-05-01

    Full Text Available In the brain of patients with multiple sclerosis, activated microglia/macrophages appear in active lesions and in normal appearing white matter. However, whether they play a beneficial or a detrimental role in the development of the pathology remains a controversial issue. The production of pro-inflammatory molecules by chronically activated microglial cells is suggested to contribute to the progression of neurodegenerative processes in neurological disease. In the healthy brain, neurons control glial activation through several inhibitory mechanisms, such as the CD200-CD200R1 interaction. Therefore, we studied whether alterations in the CD200-CD200R1 system might underlie the neuroinflammation in an experimental autoimmune encephalomyelitis (EAE model of multiple sclerosis. We determined the time course of CD200 and CD200R1 expression in the brain and spinal cord of an EAE mouse model from presymptomatic to late symptomatic stages. We also assessed the correlation with associated glial activation, inflammatory response and EAE severity. Alterations in CD200 and CD200R1 expression were mainly observed in spinal cord regions in the EAE model, mostly a decrease in CD200 and an increase in CD200R1 expression. A decrease in the expression of the mRNA encoding a full CD200 protein was detected before the onset of clinical signs, and remained thereafter. A decrease in CD200 protein expression was observed from the onset of clinical signs. By contrast, CD200R1 expression increased at EAE onset, when a glial reaction associated with the production of pro- and anti-inflammatory markers occurred, and continued to be elevated during the pathology. Moreover, the magnitude of the alterations correlated with severity of the EAE mainly in spinal cord. These results suggest that neuronal-microglial communication through CD200-CD200R1 interaction is compromised in EAE. The early decreases in CD200 expression in EAE suggest that this downregulation might also

  17. Two-stage approach for risk estimation of fetal trisomy 21 and other aneuploidies using computational intelligence systems.

    Science.gov (United States)

    Neocleous, A C; Syngelaki, A; Nicolaides, K H; Schizas, C N

    2017-06-22

    To estimate the risk of fetal trisomy 21 (T21) and other chromosomal abnormalities (OCA) at 11-13 weeks' gestation using computational intelligence classification methods. As a first step, a training dataset consisting of 72 054 euploid pregnancies, 295 cases of T21 and 305 cases of OCA was used to train an artificial neural network. Then, a two-stage approach was used for stratification of risk and diagnosis of cases of aneuploidy in the blind set. In Stage 1, using four markers, pregnancies in the blind set were classified into no risk and risk. No-risk pregnancies were not examined further, whereas the risk pregnancies were forwarded to Stage 2 for further examination. In Stage 2, using seven markers, pregnancies were classified into three types of risk, namely no risk, moderate risk and high risk. Of 36 328 unknown to the system pregnancies (blind set), 17 512 euploid, two T21 and 18 OCA were classified as no risk in Stage 1. The remaining 18 796 cases were forwarded to Stage 2, of which 7895 euploid, two T21 and two OCA cases were classified as no risk, 10 464 euploid, 83 T21 and 61 OCA as moderate risk and 187 euploid, 50 T21 and 52 OCA as high risk. The sensitivity and the specificity for T21 in Stage 2 were 97.1% and 99.5%, respectively, and the false-positive rate from Stage 1 to Stage 2 was reduced from 51.4% to ∼1%, assuming that the cell-free DNA test could identify all euploid and aneuploid cases. We propose a method for early diagnosis of chromosomal abnormalities that ensures that most T21 cases are classified as high risk at any stage. At the same time, the number of euploid cases subjected to invasive or cell-free DNA examinations was minimized through a routine procedure offered in two stages. Our method is minimally invasive and of relatively low cost, highly effective at T21 identification and it performs better than do other existing statistical methods. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd. Copyright

  18. Comorbidity, age, race and stage at diagnosis in colorectal cancer: a retrospective, parallel analysis of two health systems

    Directory of Open Access Journals (Sweden)

    Rowe Krista L

    2008-11-01

    earlier stage of CRC diagnosis. Multiple factors, perhaps including increased interactions with the healthcare system due to comorbidity, might contribute to this finding. Such increased interactions are seen among patients within a healthcare system like the VA system in the US versus sporadic interactions which may be seen with FFS healthcare.

  19. Optimization of atrazine and imidacloprid removal from water using biochars: Designing single or multi-staged batch adsorption systems.

    Science.gov (United States)

    Mandal, Abhishek; Singh, Neera

    2017-05-01

    Contamination of surface and ground water by pesticides from agricultural runoff and industrial discharge is one of the main causes of aqueous contaminations world over. Biochar, agricultural waste derived highly aromatic substance produced after pyrolysis and carbonification of biomass have exhibited good adsorption capacity for pesticides and can be used to develop on-site bio-purification systems for organic contaminant removal from polluted waters. However, high amounts of adsorbent required in single stage-batch sorption plant increases the cost of water treatment; therefore, multistage plant systems were investigated. Normal (RSBC) and phosphoric acid treated (T-RSBC) rice straw biochars were evaluated for atrazine and imidacloprid sorption and data fitted to the Freundlich isotherm. The adsorption data was modelled to develop single or multi-staged adsorber plants for pesticide removal from water. Both biochars showed significantly high adsorption capacity for imidacloprid and atrazine. Modelling studies using the Freundlich adsorption parameters suggested that the amounts (kg/1000L) of RSBC and T-RSBC for 95% of atrazine removal (10mg/L) in single-, two- and three-staged adsorber plant models were 8.84, 2.44, 1.61kg and 4.47, 1.42, 0.98kg, respectively. Corresponding amounts for 95% imidacloprid removal (10mg/L) were 3.97, 1.22, 0.84kg and 3.98, 1.38, 0.96kg, respectively. Thus, the two-staged model suggested 65-72% reduction in amount of adsorbent required over the single stage model, while the three-staged model suggested 30-34% adsorbent saving over the two-staged plant model. Single and two-staged adsorber plant model findings were validated for atrazine removal using T-RSBC. Results suggested that amounts calculated using modelling studies were fairly accurate. Biochars, as low cost adsorbents for atrazine and imidacloprid removal from contaminated water, can be used to develop low cost adsorber plants based on multiple batch sorption systems for the

  20. Mission roles for the Solar Electric Propulsion Stage (SEPS) with the space transportation system. Volume 1: Executive summary

    Science.gov (United States)

    Hammock, D. M.

    1975-01-01

    A study was conducted to determine the characteristics of solar electric propulsion stage (SEPS) for the space transportation system. Emphasis is placed on the rationale leading to the concepts for the development and operations program which enhances the cost effectiveness of the SEPS operating with the space transportation system. The approach in describing design concepts and configurations is concerned with the decision controlling factors and selection criteria. The mission roles for the SEPS in accomplishing proposed space activities are defined.

  1. Biogas upgrading by injection of hydrogen in a two-stage Continuous Stirred-Tank Reactor system

    DEFF Research Database (Denmark)

    Bassani, Ilaria; Kougias, Panagiotis; Treu, Laura

    methanogens. In this study, a novel serial biogas reactor system is presented, in which the produced biogas from the first stage reactor was introduced in the second stage, where also H2 was injected. The effects of the H2 addition on the process performance and on the microbial community were investigated....... The profiles of the microbial communities prior and after the H2 addition showed distinct differences. Changes in the archaeal community and more specifically increase in the relative abundance of Methanobrevibacter sp. and Methanoculleus sp. indicated that the methanogenic pathway was clearly shifted from...

  2. A reliability model of the Angra 1 power system by the device of stages optimized by genetic algorithms

    International Nuclear Information System (INIS)

    Crossetti, Patricia Guimaraes

    2006-01-01

    This thesis proposes a probabilistic model to perform the reliability analysis of nuclear power plant systems under aging. This work analyses the Angra 1 power system. Systems subject to aging consist of components whose failure rates are not all constant, thus generating Non-Markovian models. Genetic algorithms were used for optimizing the application of the device of stages. Two approaches were used in the optimization, MCEF and MCEV. The results obtained for the Angra 1 power system show that the probability of a station blackout is negligible. (author)

  3. Dynamite warehouse safety management system for the second stage project of Ling'ao nuclear power plant

    International Nuclear Information System (INIS)

    Tong Jiansheng

    2007-01-01

    A large amount of dynamite is stored for the second stage project of Ling'ao Nuclear Power Plant, which is applied to negative digging and provides broken stones by blasting in the project construction. The monitoring system is improved to obtain a higher safety level of the dynamite warehouse. The improved system is a combination of computer net, advanced communication, and modern control techniques, with electronic detection, current software, image processing and video display. The system integrates information, communication, control and command, with information and resources shared, therefore, unified command and dispatch can be carried out. Practice shows that the system is high-effective, intelligent, and multi-dimensional. (author)

  4. Calibration of the Hall Measurement System for a 6-DOF Precision Stage Using Self-Adaptive Hybrid TLBO.

    Science.gov (United States)

    Chen, Zhenyu; Liu, Yang; Fu, Zhenxian; Song, Shenmin; Tan, Jiubin

    2016-06-14

    To determine the planar motion of a 6-DOF precision stage, a measurement system based on three Hall sensors is adopted to obtain the X, Y, Rz motions of the stage. The machining and assembly errors in the actual mechanical system, which are difficult to measure directly, cause the parameters in the model of the Hall measurement system to deviate from their designed values. Additionally, the vertical movement of the stage will render the measurement model nonlinear. To guarantee the accuracy of the measurement, the parameters in the measurement model should be estimated and the nonlinearity compensated. In this paper, a novel approach based on self-adaptive hybrid TLBO (teaching-learning-based-optimization) is proposed to estimate the parameters in the Hall measurement model. The influences of zero deviations and vertical movements on the measurement accuracy are analyzed and compensated. The effectiveness of the proposed method is validated by experimental results obtained on a 6-DOF precision stage. Thanks to parameter estimation and calibration, the measurement error of the Hall sensor array is reduced to 6 micrometers.

  5. Diversity of imaging and pathological features at different stages of primary central nervous system lymphoma

    Directory of Open Access Journals (Sweden)

    Jing LIU

    2018-01-01

    Full Text Available Objective The clinical, imaging and pathological manifestations of one patient at different stages of primary central nervous system lymphoma (PCNSL have been analyzed to disclose its pathogenesis. Methods and Results A 29-year-old female patient showed recurrent onsets. On the first onset, the main clinical manifestation was blurred vision and visual field defect. Cranial MRI showed a patchy lesion in the right parietal and occipital lobes without obvious occupying sign. T1WI showed slight low-intensity sign, T2WI and FLAIR showed high-intensity signs. Enhanced scanning showed heterogeneous punctate enhancement. The lesion disappeared gradually after glucocorticoid impact therapy. Headache, vomiting and left limb paralysis were the main clinical manifestations on the second onset, and MRI showed a lesion in the right frontal and parietal lobes with obvious occupying sign and solid enhancement, low-intensity on T1WI, high-intensity on T2WI and FLAIR. The tumor was totally removed under microscope. Histological findings showed large tumor cells, rich cytoplasm, nuclei with various sizes and shapes, conspicuous mitosis, patchy necrosis, and interstitial small vessel hyperplasia. Immunohistochemical staining showed that membrane of tumor cells was positive for CD20, and nuclei were positive for paired box gene 5 (PAX5 and multiple myeloma oncogene 1 (MUM1. In a few tumor cells, membrane was positive for CD10 and CD30, and nuclei were positive for cyclin D1. Besides, tumor cells were negative for CD3, anaplastic lymphoma kinase (ALK and glial fibrillary acidic protein (GFAP. Ki?67 labeling index was about 80%. EBER in situ hybridization (ISH assay showed that mRNA coded by Epstein?Barr (EB virus was negative. The tumor showed angiotropic characteristics, and the walls of involved blood vessels were wrapped and destructed. The final diagnosis was confirmed as diffuse large B cell lymphoma. Conclusions PCNSL has various imaging features, revealing as

  6. GPS data analysis and results from the Geodesy Advancing Geosciences and EarthScope (GAGE) project

    Science.gov (United States)

    Herring, T.; Floyd, M.; King, R. W.; Melbourne, T. I.; Szeliga, W. M.; Murray, M. H.; Phillips, D. A.; Puskas, C. M.; Boler, F. M.; Meertens, C. M.; Mattioli, G. S.

    2014-12-01

    We report on the methods and results from the GPS data analysis part of the NSF Geodesy Advancing Geosciences and EarthScope (GAGE) project operated by UNAVCO. Current analyses include GPS data from the 1100 Plate Boundary Observatory (PBO) sites and approximately 700 other sites used to densify the network in some locations and to provide spatial extent on the North America and Pacific plates. Analyses from 1996 to present collectively include approximately 2050 unique sites over the 18-year period. The results from these analyses are updated daily for rapid solutions (~1 day latency) and weekly for initial analyses using IGS final orbits (2-3 week latency). Analyses are also run with 12- and 26-week latencies to add sites that were not available (either telemetry failures or manual download sites) during the initial analyses. Raw data are processed using two different GPS analysis programs: GAMIT at New Mexico Tech and GIPSY at Central Washington University. Combined results are then produced with GLOBK at MIT. All results are available through the UNAVCO web site in the form of time series and velocity fields in the NAM08 (Altamimi et al.'s, 2012, ITRF2008 North America Euler pole) and IGS08 frames. Daily SINEX files are provided in fiducial free and NAM08 frames. Event files are generated within a few days of earthquakes in the GAGE analysis region that generate co-seismic displacements greater than 1 mm. The median weighted root-mean-square (WRMS) scatters of combined position time series are less than 1 mm in north and east (NE) and 4 mm for vertical (U) over monthly durations. For all results processed thus far (~18 years of data for the longest running sites), WRMS scatters of the position residuals about linear trends, with offsets for earthquakes and antenna changes removed, are ~1.5 mm NE and 4.5 mm U. The top 10% of sites have short period scatters (month duration) of 0.5 mm NE and 1.9 mm U, while the long-term scatters increase to 0.8 mm NE and 3.3 mm

  7. Two-Stage n-PSK Partitioning Carrier Phase Recovery Scheme for Circular mQAM Coherent Optical Systems

    Directory of Open Access Journals (Sweden)

    Jaime Rodrigo Navarro

    2016-06-01

    Full Text Available A novel two-stage n-PSK partitioning carrier phase recovery (CPR scheme for circular multilevel quadrature amplitude modulation (C-mQAM constellations is presented. The first stage of the algorithm provides an initial rough estimation of the received constellation, which is utilized in the second stage for CPR. The performance of the proposed algorithm is studied through extensive simulations at the forward error correction bit error rate targets of 3.8 × 10−3 and 1 × 10−2 and is compared with different CPR algorithms. A significant improvement in the combined linewidth symbol duration product (ΔνTs tolerance is achieved compared to the single-stage n-PSK partitioning scheme. Superior performance in the ΔνTs tolerance compared to the blind phase search algorithm is also reported. The relative improvements with respect to other CPR schemes are also validated experimentally for a 28-Gbaud C-16QAM back-to-back transmission system. The computational complexity of the proposed CPR scheme is studied, and reduction factors of 24.5 | 30.1 and 59.1 | 63.3 are achieved for C-16QAM and C-64QAM, respectively, compared to single-stage BPS in the form of multipliers | adders.

  8. ∑∆ Modulator System-Level Considerations for Hearing-Aid Audio Class-D Output Stage Application

    DEFF Research Database (Denmark)

    Pracný, Peter; Bruun, Erik

    2012-01-01

    This paper deals with a system-level design of a digital sigma-delta (∑∆) modulator for hearing-aid audio Class D output stage application. The aim of this paper is to provide a thorough discussion on various possibilities and tradeoffs of ∑∆ modulator system-level design parameter combinations...... - order, oversampling ratio (OSR) and number of bits in the quantizer - including their impact on interpolation filter design as well. The system is kept in digital domain up to the input of the Class D power stage including the digital pulse width modulation (DPWM) block. Notes on the impact of the DPWM...... block on the modulated spectrum are provided....

  9. Modular Adaptive System Based on a Multi-Stage Neural Structure for Recognition of 2D Objects of Discontinuous Production

    Directory of Open Access Journals (Sweden)

    I. Topalova

    2005-03-01

    Full Text Available This is a presentation of a new system for invariant recognition of 2D objects with overlapping classes, that can not be effectively recognized with the traditional methods. The translation, scale and partial rotation invariant contour object description is transformed in a DCT spectrum space. The obtained frequency spectrums are decomposed into frequency bands in order to feed different BPG neural nets (NNs. The NNs are structured in three stages - filtering and full rotation invariance; partial recognition; general classification. The designed multi-stage BPG Neural Structure shows very good accuracy and flexibility when tested with 2D objects used in the discontinuous production. The reached speed and the opportunuty for an easy restructuring and reprogramming of the system makes it suitable for application in different applied systems for real time work.

  10. Mission roles for the solar electric propulsion stage with the space transportation system

    Science.gov (United States)

    1974-01-01

    A briefing outline is presented of the mission roles for the solar electric propulsion stage (SEPS). Topics outlined include operational considerations and mission characteristics, trade studies and technology assessments influencing SEPS configuration definition, program support requirements, and development and operations cost estimates.

  11. Multi-Stage Optimization-Based Automatic Voltage Control Systems Considering Wind Power Forecasting Errors

    DEFF Research Database (Denmark)

    Qin, Nan; Bak, Claus Leth; Abildgaard, Hans

    2017-01-01

    cost and the generator reactive power output cost. The problem is formulated in a multi-stage optimal reactive power flow (MORPF) framework, solved by the nonlinear programming techniques via a rolling process. The voltage uncertainty caused by wind power forecasting errors is considered in the optimal...

  12. Advanced Development Program for a 625 lbf thrust engine for Ares First Stage Roll Control System

    Science.gov (United States)

    Dawson, Matt; Chenevert, Blake; Brewster, Gerry; Frei, Tom; Bullard, Brad; Fuller, Ray

    2009-01-01

    NASA's new Ares Launch Vehicle will require twelve thrusters to provide roll control of the vehicle during the first stage firing. All twelve roll control thrusters will be located at the inter-stage segment that separates the solid rocket booster first stage from the second stage. NASA selected a mono propellant hydrazine solution and as a result awarded Aerojet-General a contract in 2007 for an advanced development program for an MR-80- series 625 Ibf vacuum thrust monopropellant hydrazine thruster. This thruster has heritage dating back to the 1976 Viking Landers and most recently for the 2011 Mars Science Laboratory. Prior to the Ares application, the MR-80-series thrusters had been equipped with throttle valves and not typically operated in pulse mode. The primary objective of the advanced development program was to increase the technology readiness level and retire major technical risks for the future flight qualification test program. Aerojet built on their heritage MR-80 rocket engine designs to achieve the design and performance requirements. Significant improvements to cost and lead-time were achieved by applying Design for Manufacturing and Assembly (DFMA) principles. AerojetGeneral has completed Preliminary and Critical Design Reviews, followed by two successful rocket engine development test programs. The test programs included qualification random vibration and firing lite that significantly exceed the flight qualification requirements. This paper discusses the advanced development program and the demonstrated capability of the MR-80C engine. Y;

  13. Exergy and energy analysis of three stage auto refrigerating cascade system using Zeotropic mixture for sustainable development

    International Nuclear Information System (INIS)

    Sivakumar, M.; Somasundaram, P.

    2014-01-01

    Highlights: • Zeotropic mixture of R290/R23/R14 works with 22.6% increased exergic efficiency. • Zeotropic mixture of mass fraction 0.218:0.346:0.436 offers COP of 0.253. • Since emphasis on COP, evaporating temperature 0.253 COP became the only alternate. • This is the only alternate refrigerant mixture for three stage ARC system at −97 °C. - Abstract: The Zeotropic mixture of environment friendly refrigerants (HC’s and HFC’s) being the only alternatives for working fluid in low temperature refrigeration system and hence three stage auto refrigerating cascade (ARC) system was studied for the existence using two combinations of (R290/R23/R14, R1270/R170/R14) three component Zeotropic mixture of five different refrigerants. The exergy analysis confirmed the existence of three stage ARC system. The performances of the system like Coefficient of Performance (COP), exergy lost, exergic efficiency, efficiency defect and the evaporating temperature achieved were investigated for different mass fractions in order to verify the effect of mass fraction on them. In accordance with the environmental issues and the process of sustainable development, the three component Zeotropic mixture of R290/R23/R14 with the mass fraction of 0.218:0.346:0.436 was performing better and hence can be suggested as an alternative refrigerant for three stage ARC system operating at very low evaporating temperature in the range of 176 K (−97 °C) at COP of 0.253 with 58.5% exergic efficiency (comparatively 22.6% increased value)

  14. Anaerobic wastewater treatment of concentrated sewage using a two-stage upflow anaerobic sludge blanket- anaerobic filter system.

    Science.gov (United States)

    Halalsheh, Maha M; Abu Rumman, Zainab M; Field, Jim A

    2010-01-01

    A two-stage pilot-scale upflow anaerobic sludge blanket - anaerobic filter (UASB-AF) reactors system treating concentrated domestic sewage was operated at 23 degrees C and at hydraulic retention times (HRT) of 15 and 4 h, respectively. Excess sludge from the downstream AF stage was returned to the upstream UASB reactor. The aim was to obtain higher sludge retention time (SRT) in the UASB reactor for better methanization of suspended COD. The UASB-AF system removed 55% and 65% of the total COD (COD(tot)) and suspended COD (COD(ss)), respectively. The calculated SRT in the UASB reactor ranged from 20-35 days. The AF reactor removed the washed out sludge from the first stage reactor with average COD(ss) removal efficiency of 55%. The volatile fatty acids concentration in the effluent of the AF was 39 mg COD/L compared with 78 mg COD/L measured for the influent. The slightly higher COD(tot) removal efficiency obtained in this study compared with a single stage UASB reactor was achieved at 17% reduction in the total volume.

  15. Complementary system for monitoring and control of neutron flux during a fuel outage and during reactor start up stage

    International Nuclear Information System (INIS)

    Lichkov, R.

    2000-01-01

    The present work is an example for that, how with modern technical instruments is possible to compensate disadvantage and to increase technical resources of the old systems, without a change of given system totally with new one. The system detail design and implementation was possible mostly, due to the international conferences and courses organised by IAEA and technical information provided by the agency. The designed system plays a role of complementary system to the in-situ operational systems for monitoring and control of the reactor core neutron flux, allowing its measurement and control during a fuel outage and during reactor start up stage. Additionally, the system recalculates the reactivity in beta units and according to its value the reactor criticality fixed up reactivity is defined. (author)

  16. Review of Trackside Monitoring Solutions: From Strain Gages to Optical Fibre Sensors

    Directory of Open Access Journals (Sweden)

    Georges Kouroussis

    2015-08-01

    Full Text Available A review of recent research on structural monitoring in railway industry is proposed in this paper, with a special focus on stress-based solutions. After a brief analysis of the mechanical behaviour of ballasted railway tracks, an overview of the most common monitoring techniques is presented. A special attention is paid on strain gages and accelerometers for which the accurate mounting position on the track is requisite. These types of solution are then compared to another modern approach based on the use of optical fibres. Besides, an in-depth discussion is made on the evolution of numerical models that investigate the interaction between railway vehicles and tracks. These models are used to validate experimental devices and to predict the best location(s of the sensors. It is hoped that this review article will stimulate further research activities in this continuously expanding field.

  17. Review of Trackside Monitoring Solutions: From Strain Gages to Optical Fibre Sensors.

    Science.gov (United States)

    Kouroussis, Georges; Caucheteur, Christophe; Kinet, Damien; Alexandrou, Georgios; Verlinden, Olivier; Moeyaert, Véronique

    2015-08-14

    A review of recent research on structural monitoring in railway industry is proposed in this paper, with a special focus on stress-based solutions. After a brief analysis of the mechanical behaviour of ballasted railway tracks, an overview of the most common monitoring techniques is presented. A special attention is paid on strain gages and accelerometers for which the accurate mounting position on the track is requisite. These types of solution are then compared to another modern approach based on the use of optical fibres. Besides, an in-depth discussion is made on the evolution of numerical models that investigate the interaction between railway vehicles and tracks. These models are used to validate experimental devices and to predict the best location(s) of the sensors. It is hoped that this review article will stimulate further research activities in this continuously expanding field.

  18. Force instrumentation for cryogenic wind tunnels using one-piece strain-gage balances

    Science.gov (United States)

    Ferris, A. T.; Moore, T. C.

    1981-01-01

    Materials and techniques for a transducer capable of obtaining accurate force measurements at cryogenic temperatures (down to 77 K) and high pressures (up to 9 atm) have been determined. Areas of high stress concentration are minimized by balance design, and model and sting attachment methods able to withstand cryogenic temperatures are used. Maraging 200 is the material used for the balances, due to its high impact strength and simple heat treatment procedure. Test results verify that the balances produce reliable, repeatable, and predictable data from 300 K to 110 K under steady state conditions. Techniques have been developed to reduce the temperature-induced bridge output, such as the use of bridges with two gages mounted transverse to the principal stress direction. Under these conditions, the results given by the balances should be equally good during transient temperatures on five of the six components. The work will be used at the National Transonic Facility (NTF) at NASA Langley.

  19. Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma

    International Nuclear Information System (INIS)

    Kim, Yun-Sook; Hwan Do, Jin; Bae, Sumi; Bae, Dong-Han; Shick Ahn, Woong

    2010-01-01

    Most patients with ovarian cancer are diagnosed with advanced stage disease (i.e., stage III-IV), which is associated with a poor prognosis. Differentially expressed genes (DEGs) in stage III serous ovarian carcinoma compared to normal tissue were screened by a new differential display method, the annealing control primer (ACP) system. The potential targets for markers that could be used for diagnosis and prognosis, for stage III serous ovarian cancer, were found by cluster and survival analysis. The ACP-based reverse transcriptase polymerase chain reaction (RT PCR) technique was used to identify DEGs in patients with stage III serous ovarian carcinoma. The DEGs identified by the ACP system were confirmed by quantitative real-time PCR. Cluster analysis was performed on the basis of the expression profile produced by quantitative real-time PCR and survival analysis was carried out by the Kaplan-Meier method and Cox proportional hazards multivariate model; the results of gene expression were compared between chemo-resistant and chemo-sensitive groups. A total of 114 DEGs were identified by the ACP-based RT PCR technique among patients with stage III serous ovarian carcinoma. The DEGs associated with an apoptosis inhibitory process tended to be up-regulated clones while the DEGs associated with immune response tended to be down-regulated clones. Cluster analysis of the gene expression profile obtained by quantitative real-time PCR revealed two contrasting groups of DEGs. That is, a group of genes including: SSBP1, IFI6 DDT, IFI27, C11orf92, NFKBIA, TNXB, NEAT1 and TFG were up-regulated while another group of genes consisting of: LAMB2, XRCC6, MEF2C, RBM5, FOXP1, NUDCP2, LGALS3, TMEM185A, and C1S were down-regulated in most patients. Survival analysis revealed that the up-regulated genes such as DDAH2, RNase K and TCEAL2 might be associated with a poor prognosis. Furthermore, the prognosis of patients with chemo-resistance was predicted to be very poor when genes such

  20. Two-stage open-loop velocity compensating method applied to multi-mass elastic transmission system

    Directory of Open Access Journals (Sweden)

    Zhang Deli

    2014-02-01

    Full Text Available In this paper, a novel vibration-suppression open-loop control method for multi-mass system is proposed, which uses two-stage velocity compensating algorithm and fuzzy I + P controller. This compensating method is based on model-based control theory in order to provide a damping effect on the system mechanical part. The mathematical model of multi-mass system is built and reduced to estimate the velocities of masses. The velocity difference between adjacent masses is calculated dynamically. A 3-mass system is regarded as the composition of two 2-mass systems in order to realize the two-stage compensating algorithm. Instead of using a typical PI controller in the velocity compensating loop, a fuzzy I + P controller is designed and its input variables are decided according to their impact on the system, which is different from the conventional fuzzy PID controller designing rules. Simulations and experimental results show that the proposed velocity compensating method is effective in suppressing vibration on a 3-mass system and it has a better performance when the designed fuzzy I + P controller is utilized in the control system.

  1. Assessment of the Uniqueness of Wind Tunnel Strain-Gage Balance Load Predictions

    Science.gov (United States)

    Ulbrich, N.

    2016-01-01

    A new test was developed to assess the uniqueness of wind tunnel strain-gage balance load predictions that are obtained from regression models of calibration data. The test helps balance users to gain confidence in load predictions of non-traditional balance designs. It also makes it possible to better evaluate load predictions of traditional balances that are not used as originally intended. The test works for both the Iterative and Non-Iterative Methods that are used in the aerospace testing community for the prediction of balance loads. It is based on the hypothesis that the total number of independently applied balance load components must always match the total number of independently measured bridge outputs or bridge output combinations. This hypothesis is supported by a control volume analysis of the inputs and outputs of a strain-gage balance. It is concluded from the control volume analysis that the loads and bridge outputs of a balance calibration data set must separately be tested for linear independence because it cannot always be guaranteed that a linearly independent load component set will result in linearly independent bridge output measurements. Simple linear math models for the loads and bridge outputs in combination with the variance inflation factor are used to test for linear independence. A highly unique and reversible mapping between the applied load component set and the measured bridge output set is guaranteed to exist if the maximum variance inflation factor of both sets is less than the literature recommended threshold of five. Data from the calibration of a six{component force balance is used to illustrate the application of the new test to real-world data.

  2. Combined intra-arterial infusion and systemic chemoradiotherapy for stage IV squamous cell carcinoma of the mandibular gingiva

    International Nuclear Information System (INIS)

    Nakasato, Tatsuhiko; Akahane, Akio; Kikuchi, Koyo; Ehara, Shigeru; Izumisawa, Mitsuru; Shoji, Satoru; Kogi, Shintaro; Mizuki, Harumi; Sugiyama, Yoshiki

    2012-01-01

    The purpose of this study was to show the effectiveness of combining intra-arterial infusion and systemic chemotherapy with concurrent radiotherapy for treatment of stage IV mandibular gingival cancer. A total of 23 patients with mandibular gingival cancer were treated with either docetaxel by intra-arterial infusion followed by systemic chemoradiotherapy with cisplatinum and 5-fluorouracil as a monthly regimen, or with docetaxel and cisplatinum by intra-arterial infusion followed by systemic chemoradiotherapy with 5-fluorouracil as a weekly or biweekly regimen. Tumor responses, locoregional control, overall survival, disease-specific survival, and adverse events were evaluated. Of the 23 patients enrolled in the study, 22 completed the treatment. With regard to clinical stages, 82% were diagnosed as IVA and 18% IVB. Complete and partial response was observed in 82 and 18%, respectively. Five-year overall survival, disease-specific survival, and locoregional control were 51, 70, and 72%, respectively. No statistically significant difference was seen between the monthly regimen and the weekly plus biweekly regimen, although the latter resulted in longer survival and 88% control. Combined intra-arterial infusion and systemic chemoradiotherapy may be an effective treatment for patients with stage IV mandibular gingival cancer. (author)

  3. Staged fuel and air injection in combustion systems of gas turbines

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, Michael John; Berry, Jonathan Dwight

    2018-04-10

    A gas turbine including a working fluid flowpath extending aftward from a forward injector in a combustor. The combustor may include an inner radial wall, an outer radial wall, and, therebetween, a flow annulus, and a third radial wall formed about the outer radial wall that forms an outer flow annulus. A staged injector may intersect the flow annulus so to attain an injection point within the working fluid flowpath by which aftward and forward annulus sections are defined. Air directing structure may include an aftward intake section corresponding to the aftward annulus section and a forward intake section corresponding to the forward annulus section. The air directing structure may include a switchback coolant flowpath to direct air from the compressor discharge cavity to the staged injector. The switchback coolant flowpath may include an upstream section through the flow annulus, and a downstream section through the outer flow annulus.

  4. THE EVALUATION SYSTEM OF DESIGN SOLUTIONS FOR RESIDENTIAL PROPERTY ON THE PRE-INVESTMENT STAGE THROUGH NEURAL NETWORK TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    G. D. Kostsikava

    2016-01-01

    Full Text Available Ever since the Soviet Union design solutions were evaluated according to different criteria and indicators. At the present stage of evaluation systems of design solutions stands systemengineering doctrine is allocated. It is complemented by the theory of efficiency and financial sustainability investment project in view of the general market concept. Also great attention is paid to the virtual object modeling. It is urgent to include the behavior prediction of an investment construction project model at each stage of its life cycle. The high cost of all phases of this life cycle makes it necessary to calculate the feasibility of the investment. Very urgent to do it as accurately as possible and before we start of design works on the stage of the investment plan evaluation. Belarus has legislated pre-investment stage of construction project development. To evaluate the design solution at this stage is necessary to develop an investment justification, a project management plan and a business plan. They will evaluate and will compare several options for future objects by the complex. This requires not only time, but considerable financial costs. In order to optimize the process to develop an evaluation system design solutions based on existing projects. It allows the customer (investor choose design solutions to build the object without developing of pre-design documentations for several options. This system it is advisable to try out the example of apartment house building with the assistance of the national fund of project documentation and objects-analogues data bank. The developed evaluation system of design solutions for residential real estate objects in the pre-investment stage is supposed to use the theory of neural networks and neyroprogramming. This system bases on the input parameters projects. The hidden layer neurons are trained to choose suitable projects of apartment houses with their classification. The projects will be classified

  5. The effect of machining the gage section on Biaxial Tension/Shear plasticity experiments of DP780 sheet steel

    NARCIS (Netherlands)

    Walters, C.L.

    2013-01-01

    An experimental approach for determining the effect of machining the gage section of specimens for quasi-static, biaxial tension/shear testing of sheet steels is described. This method is demonstrated by comparing the results found by an existing testing method with a reduced thickness (Mohr and

  6. Nuclear Technology. Course 27: Metrology. Module 27-4, Angle Measurement Instruments, Optical Projections and Surface Texture Gages.

    Science.gov (United States)

    Selleck, Ben; Espy, John

    This fourth in a series of eight modules for a course titled Metrology describes the universal bevel protractor and the sine bar, the engineering microscope and optical projector, and several types of surface texture gages. The module follows a typical format that includes the following sections: (1) introduction, (2) module prerequisites, (3)…

  7. DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection

    OpenAIRE

    Gorna, AE; Bowater, RP; Dziadek, J

    2010-01-01

    Mycobacteria, including most of all MTB (Mycobacterium tuberculosis), cause pathogenic infections in humans and, during the infectious process, are exposed to a range of environmental insults, including the host's immune response. From the moment MTB is exhaled by infected individuals, through an active and latent phase in the body of the new host, until the time they reach the reactivation stage, MTB is exposed to many types of DNA-damaging agents. Like all cellular organisms, MTB has effici...

  8. Waste-gasification efficiency of a two-stage fluidized-bed gasification system.

    Science.gov (United States)

    Liu, Zhen-Shu; Lin, Chiou-Liang; Chang, Tsung-Jen; Weng, Wang-Chang

    2016-02-01

    This study employed a two-stage fluidized-bed gasifier as a gasification reactor and two additives (CaO and activated carbon) as the Stage-II bed material to investigate the effects of the operating temperature (700°C, 800°C, and 900°C) on the syngas composition, total gas yield, and gas-heating value during simulated waste gasification. The results showed that when the operating temperature increased from 700 to 900°C, the molar percentage of H2 in the syngas produced by the two-stage gasification process increased from 19.4 to 29.7mol% and that the total gas yield and gas-heating value also increased. When CaO was used as the additive, the molar percentage of CO2 in the syngas decreased, and the molar percentage of H2 increased. When activated carbon was used, the molar percentage of CH4 in the syngas increased, and the total gas yield and gas-heating value increased. Overall, CaO had better effects on the production of H2, whereas activated carbon clearly enhanced the total gas yield and gas-heating value. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  9. Multi-stage diffused bubble aeration system for the removal of volatile organics and radon--A case history

    International Nuclear Information System (INIS)

    Marino, A.D.; Lowry, J.

    1992-01-01

    Community acceptance of a water treatment plant project in the 1990's is just as important as the technical performance of the equipment. The low profile of the multi-stage diffused bubble aeration system, as well as the technical performance of this equipment, provides the perfect solution for water treatment facilities that are constructed in residential areas. This case history involves the installation of a multi-stage diffused bubble system in a residential neighborhood in New Jersey without compromising any of the aesthetic qualities. As a result of a routine monitoring program, low levels of trichloroethylene were detected in the outcrop area. At the same time, routine analysis for radon in the source of supplies indicated that the wells located in the outcrop area showed levels of radon between 800 and 1,150 picoCuries per liter

  10. Multi-stage crypto ransomware attacks: A new emerging cyber threat to critical infrastructure and industrial control systems

    Directory of Open Access Journals (Sweden)

    Aaron Zimba

    2018-03-01

    Full Text Available The inevitable integration of critical infrastructure to public networks has exposed the underlying industrial control systems to various attack vectors. In this paper, we model multi-stage crypto ransomware attacks, which are today an emerging cyber threat to critical infrastructure. We evaluate our modeling approach using multi-stage attacks by the infamous WannaCry ransomware. The static malware analysis results uncover the techniques employed by the ransomware to discover vulnerable nodes in different SCADA and production subnets, and for the subsequent network propagation. Based on the uncovered artifacts, we recommend a cascaded network segmentation approach, which prioritizes the security of production network devices. Keywords: Critical infrastructure, Cyber-attack, Industrial control system, Crypto ransomware, Vulnerability

  11. An inexact two-stage stochastic energy systems planning model for managing greenhouse gas emission at a municipal level

    International Nuclear Information System (INIS)

    Energy management systems are highly complicated with greenhouse-gas emission reduction issues and a variety of social, economic, political, environmental and technical factors. To address such complexities, municipal energy systems planning models are desired as they can take account of these factors and their interactions within municipal energy management systems. This research is to develop an interval-parameter two-stage stochastic municipal energy systems planning model (ITS-MEM) for supporting decisions of energy systems planning and GHG (greenhouse gases) emission management at a municipal level. ITS-MEM is then applied to a case study. The results indicated that the developed model was capable of supporting municipal energy systems planning and environmental management under uncertainty. Solutions of ITS-MEM would provide an effective linkage between the pre-regulated environmental policies (GHG-emission reduction targets) and the associated economic implications (GHG-emission credit trading).

  12. Two-stage absorber systems - Economically viable combined heat and cold generation; Wirtschaftlicher Kraft-Waerme-Kaelte-Verbund

    Energy Technology Data Exchange (ETDEWEB)

    Biniossek, H. [Giesecke und Devrient, Muenchen (Germany); Schmid, W. [Technische Gebaeudeausruestung, Muenchen (Germany)

    2008-07-01

    This article takes a look at how the possibilities of optimising power, heat and cold generation for the German Giesecke and Devrient company were examined and implemented. The company, which produces banknotes and chip-cards, chose the combination of a Combined Heat and Power (CHP) Unit and a two-stage absorber refrigeration system. The company's old system is briefly described and the reasons for replacing it are discussed. The careful dimensioning of the new system and the search for appropriate equipment are described. Intelligent power flows and a cooling system with two different temperature levels are described. Costs saved and emergency power generation are also looked at, as are the complex demands placed on the control of the system. The system's functioning is briefly described.

  13. Cervical vertebral maturation: An objective and transparent code staging system applied to a 6-year longitudinal investigation.

    Science.gov (United States)

    Perinetti, Giuseppe; Bianchet, Alberto; Franchi, Lorenzo; Contardo, Luca

    2017-05-01

    To date, little information is available regarding individual cervical vertebral maturation (CVM) morphologic changes. Moreover, contrasting results regarding the repeatability of the CVM method call for the use of objective and transparent reporting procedures. In this study, we used a rigorous morphometric objective CVM code staging system, called the "CVM code" that was applied to a 6-year longitudinal circumpubertal analysis of individual CVM morphologic changes to find cases outside the reported norms and analyze individual maturation processes. From the files of the Oregon Growth Study, 32 subjects (17 boys, 15 girls) with 6 annual lateral cephalograms taken from 10 to 16 years of age were included, for a total of 221 recordings. A customized cephalometric analysis was used, and each recording was converted into a CVM code according to the concavities of cervical vertebrae (C) C2 through C4 and the shapes of C3 and C4. The retrieved CVM codes, either falling within the reported norms (regular cases) or not (exception cases), were also converted into the CVM stages. Overall, 31 exception cases (14%) were seen. with most of them accounting for pubertal CVM stage 4. The overall durations of the CVM stages 2 to 4 were about 1 year, even though only 4 subjects had regular annual durations of CVM stages 2 to 5. Whereas the overall CVM changes are consistent with previous reports, intersubject variability must be considered when dealing with individual treatment timing. Future research on CVM may take advantage of the CVM code system. Copyright © 2017 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  14. High performance work systems and employee well-being: a two stage study of a rural Australian hospital.

    Science.gov (United States)

    Young, Suzanne; Bartram, Timothy; Stanton, Pauline; Leggat, Sandra G

    2010-01-01

    This paper aims to explore the attitudes of managers and employees to high performance work practices (HPWS) in a medium sized rural Australian hospital. The study consists of two stages. Stage one involved a qualitative investigation consisting of interviews and focus group sessions with senior, middle and line management at the hospital. Bowen and Ostroffs framework was used to examine how strategic HRM was understood, interpreted and operationalised across the management hierarchy. Stage one investigates the views of managers concerning the implementation of strategic HRM/HPWS. Stage two consisted of a questionnaire administered to all hospital employees. The mediation effects of social identification on the relationship between high performance work systems and affective commitment and job satisfaction are examined. The purpose of stage two was to investigate the views and effects of SHRM/HPWS on employees. It should be noted that HPWS and strategic HRM are used inter-changeably in this paper. At the management level the importance of distinctiveness, consistency and consensus in the interpretation of strategic HRM/HPWS practices across the organization was discovered. Findings indicate that social identification mediates the relationship between HPWS and affective commitment and also mediates the relationship between HPWS and job satisfaction. High performance work systems may play a crucial role facilitating social identification at the unit level. Such practices and management support is likely to provide benefits in terms of high performing committed employees. The paper argues that team leaders and managers play a key role in building social identification within the team and that organizations need to understand this role and provide recognition, reward, education and support to their middle and lower managers.

  15. The Dynamics of an Impulsive Predator-Prey System with Stage Structure and Holling Type III Functional Response

    Directory of Open Access Journals (Sweden)

    Zhixiang Ju

    2015-01-01

    Full Text Available Based on the biological resource management of natural resources, a stage-structured predator-prey model with Holling type III functional response, birth pulse, and impulsive harvesting at different moments is proposed in this paper. By applying comparison theorem and some analysis techniques, the global attractivity of predator-extinction periodic solution and the permanence of this system are studied. At last, examples and numerical simulations are given to verify the validity of the main results.

  16. Experimental study on two-stage compression refrigeration/heat pump system with dual-cylinder rolling piston compressor

    International Nuclear Information System (INIS)

    Shuxue, Xu; Guoyuan, Ma

    2014-01-01

    A thermodynamically analytical model on the two-stage compression refrigeration/heat pump system with vapor injection was derived. The optimal volume ratio of the high-pressure cylinder to the low-pressure one has been discussed under both cooling and heating conditions. Based on the above research, the prototype was developed and its experimental setup established. A comprehensive experiments for the prototype have been conducted, and the results show that, compared with the single-stage compression heat pump system, the cooling capacity and cooling COP can increase 5%–15% and 10–12%, respectively. Also, the heating capacity with the evaporating temperature ranging from 0.3 to 3 °C is 92–95% of that under the rate condition with the evaporating temperature of 7 °C, and 58% when the evaporation temperature is between −28 °C and −24 °C. -- Highlights: • The volume ratio of the compressor is between 0.65 and 0.78 and the relative vapor injection mass ranges from 15% to 20%. • The cooling capacity and COP of the two-stage compression system can improve 5%–15% and 10%–12%. • The heating capacity can also be improved under low temperature condition

  17. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines

    Directory of Open Access Journals (Sweden)

    Yu Hao

    2010-04-01

    Full Text Available Abstract Background To observe mRNA expression of tumor-specific antigen MAGE, BAGE and GAGE in epithelial ovarian cancer tissues and cell lines, to explore the relationship between gene expression and diagnosis, treatment and prognosis of ovarian cancer, and to evaluate the feasibility of their gene products as markers, and an immunotherapy target for ovarian cancer. Methods mRNA expression of MAGE-1, MAGE-3, GAGE-1/2 and BAGE were determined by reverse transcription polymerase chain reaction (RT-PCR in 14 cases of normal ovarian tissue, 20 cases of ovarian benign tumor specimens, 41 cases of ovarian cancer specimens, and ovarian cancer cell lines SKOV3, A2780, and COC1. Results MAGE, GAGE and BAGE genes were not expressed in normal ovarian tissue. In benign tumors, only the MAGE gene was expressed; the expression rate of this gene in benign tumors was 15% (3/20. In ovarian cancer tissues, MAGE-1 and MAGE-3 was highly expressed, with expression rates of 53.7% (22/41 and 36.6% (15/41, while GAGE-1/2 and BAGE had relatively low expression, with rates of 26.8% (11/41 and 14.6% (6/41. In metastatic lesions of ovarian cancer, only MAGE-1 and BAGE were expressed, with expression rates of 28.6% (2/7 and 14.3% (1/7. The positive expression rates of MAGE-1 and MAGE-3 in serous cystadenocarcinoma were significantly higher than that in other types of ovarian cancer (P P Conclusion Tumor-specific antigen MAGE, BAGE and GAGE may play a role in the occurrence and development of ovarian cancer. These genes can be used as one of the important indicators for early diagnosis, efficacy evaluation and prognostic determination of ovarian cancer.

  18. Research on Operation Strategy for Bundled Wind-thermal Generation Power Systems Based on Two-Stage Optimization Model

    Science.gov (United States)

    Sun, Congcong; Wang, Zhijie; Liu, Sanming; Jiang, Xiuchen; Sheng, Gehao; Liu, Tianyu

    2017-05-01

    Wind power has the advantages of being clean and non-polluting and the development of bundled wind-thermal generation power systems (BWTGSs) is one of the important means to improve wind power accommodation rate and implement “clean alternative” on generation side. A two-stage optimization strategy for BWTGSs considering wind speed forecasting results and load characteristics is proposed. By taking short-term wind speed forecasting results of generation side and load characteristics of demand side into account, a two-stage optimization model for BWTGSs is formulated. By using the environmental benefit index of BWTGSs as the objective function, supply-demand balance and generator operation as the constraints, the first-stage optimization model is developed with the chance-constrained programming theory. By using the operation cost for BWTGSs as the objective function, the second-stage optimization model is developed with the greedy algorithm. The improved PSO algorithm is employed to solve the model and numerical test verifies the effectiveness of the proposed strategy.

  19. Detection of the airway obstruction stage in asthma using impulse oscillometry system.

    Science.gov (United States)

    Qi, Guang-Sheng; Zhou, Zhi-Cai; Gu, Wen-Chao; Xi, Feng; Wu, Hao; Yang, Wen-Lan; Liu, Jin-Ming

    2013-02-01

    Although spirometry is the most common method for evaluating the airway obstruction stage in asthma patients, it is difficult to perform in some patients. The aim of this study was to evaluate whether impulse oscillometry, an easy-to-perform technique, can detect asthmatic airway obstruction stage. A total of 80 subjects, including healthy volunteers and patients with asthma, were enrolled in this study. The asthma patients were classified into three groups according to American Thoracic Society (ATS)/European Respiratory Society (ERS)-2005: the mild group (forced expiratory volume in 1 second (FEV(1)) ≥ 70% predicted (Pred), n = 20), the moderate group (50% Pred ≤ FEV(1) IOS) parameters were obtained from every subject. Correlation analysis was used to compare spirometry measurements and IOS parameters. One-way analysis of variance (ANOVA) was performed to compare IOS parameters among different groups. The potential of using all individual IOS parameters to detect the different stages of asthmatic airway obstruction was evaluated by the receiver operating characteristic (ROC) curve analysis. The correlation analysis showed that IOS parameters, such as respiratory resistance at 5 Hz (R(5)), respiratory resistance at 10 Hz (R(10)), respiratory resistance at 20 Hz (R(20)), difference in resistance between 5 Hz and 20 Hz (R(5-20)), impedance at 5 Hz (Z(5)), resonant frequency (Fres), and area of reactance (AX) were negatively correlated with FEV(1) and peak expiratory flow (PEF), while reactance at 5 Hz (X(5)) was positively correlated with FEV(1) and PEF. The increase in R(5), R(10), R(20), Z(5), R(5-20), Fres, (-X(5)), and AX parameters corresponded significantly with an increase in the airway obstruction stage, as determined by one-way ANOVA . ROC curve analysis revealed that all the IOS parameters studied, except for Fres, were capable of classifying asthmatic airway obstruction. R(5), R(5-20), and Z(5) were the most accurate parameters. IOS provides an

  20. Single-stage MPPT control realization for Aalborg inverter in photovoltaic system

    DEFF Research Database (Denmark)

    Zhang, Shuai; Wu, Weimin; Wang, Houqing

    2017-01-01

    In this paper, the single-stage Maximum Power Point Tracking (MPPT) control strategy for the Aalborg photovoltaic inverter is presented. Aalborg inverter has many advantages, such as high efficiency, wide range of input voltage, minimum voltage drop of the filtering inductors, etc. Nevertheless......, it is essentially a “half-bridge” inverter with two input sources, where one source works in MPPT mode, the other is out of control. If without the reasonable parameter design and the proper control, the bus-voltage of this inverter may change greatly, resulting in the serious power oscillation around maximum power...... that the proposed control strategy has good steady-state and dynamic performances....

  1. GRID-CONNECTECD DOUBLE-STAGE AC-AC POWER CONVERTER FOR CSP RENEWABLE ENERGY SYSTEMS

    OpenAIRE

    Sorrentino, Vincenzo

    2015-01-01

    In the last years the renewable energy sources have known a state of their advanced diffusion considering their advantages compared to the traditional energy sources like fossil fuels. For this reason the combined heat and power (CHP) plant fueled by renewable sources are widely used. The purpose of this Ph.D. thesis is the design of a new Grid-connected Double-Stage AC-DC/DC-AC Power Converter (DSACPC) for a Concentrating Solar plant for Combined generation of Heat and Power (CS-CHP), th...

  2. A rapid method for optimization of the rocket propulsion system for single-stage-to-orbit vehicles

    Science.gov (United States)

    Eldred, C. H.; Gordon, S. V.

    1976-01-01

    A rapid analytical method for the optimization of rocket propulsion systems is presented for a vertical take-off, horizontal landing, single-stage-to-orbit launch vehicle. This method utilizes trade-offs between propulsion characteristics affecting flight performance and engine system mass. The performance results from a point-mass trajectory optimization program are combined with a linearized sizing program to establish vehicle sizing trends caused by propulsion system variations. The linearized sizing technique was developed for the class of vehicle systems studied herein. The specific examples treated are the optimization of nozzle expansion ratio and lift-off thrust-to-weight ratio to achieve either minimum gross mass or minimum dry mass. Assumed propulsion system characteristics are high chamber pressure, liquid oxygen and liquid hydrogen propellants, conventional bell nozzles, and the same fixed nozzle expansion ratio for all engines on a vehicle.

  3. Numerical analysis of flow interaction of turbine system in two-stage turbocharger of internal combustion engine

    Science.gov (United States)

    Liu, Y. B.; Zhuge, W. L.; Zhang, Y. J.; Zhang, S. Y.

    2016-05-01

    To reach the goal of energy conservation and emission reduction, high intake pressure is needed to meet the demand of high power density and high EGR rate for internal combustion engine. Present power density of diesel engine has reached 90KW/L and intake pressure ratio needed is over 5. Two-stage turbocharging system is an effective way to realize high compression ratio. Because turbocharging system compression work derives from exhaust gas energy. Efficiency of exhaust gas energy influenced by design and matching of turbine system is important to performance of high supercharging engine. Conventional turbine system is assembled by single-stage turbocharger turbines and turbine matching is based on turbine MAP measured on test rig. Flow between turbine system is assumed uniform and value of outlet physical quantities of turbine are regarded as the same as ambient value. However, there are three-dimension flow field distortion and outlet physical quantities value change which will influence performance of turbine system as were demonstrated by some studies. For engine equipped with two-stage turbocharging system, optimization of turbine system design will increase efficiency of exhaust gas energy and thereby increase engine power density. However flow interaction of turbine system will change flow in turbine and influence turbine performance. To recognize the interaction characteristics between high pressure turbine and low pressure turbine, flow in turbine system is modeled and simulated numerically. The calculation results suggested that static pressure field at inlet to low pressure turbine increases back pressure of high pressure turbine, however efficiency of high pressure turbine changes little; distorted velocity field at outlet to high pressure turbine results in swirl at inlet to low pressure turbine. Clockwise swirl results in large negative angle of attack at inlet to rotor which causes flow loss in turbine impeller passages and decreases turbine

  4. The Prognostic Value of the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging System in HER2-Enriched Subtype Breast Cancer, a Retrospective Analysis.

    Science.gov (United States)

    Zhou, Bin; Xu, Ling; Ye, Jingming; Xin, Ling; Duan, Xuening; Liu, Yinhua

    2017-08-01

    The American Joint Committee on Cancer (AJCC) released its 8th edition of tumor staging which is to be implemented in early 2018. The present study aimed to analyze the prognostic value of AJCC 8th edition Cancer Staging System in HER2-enriched breast cancer, on a retrospective cohort. This study was a retrospective single-center study of HER2-enriched breast cancer cases diagnosed from January 2008 to December 2014. Clinicopathological features and follow up data including disease-free survival (DFS) and overall survival (OS) were analyzed to explore prognostic factors for disease outcome. We restaged patients based on the 8th edition of the AJCC cancer staging system and analyzed prognostic value of the Anatomic Stage Group and the Prognostic Stage Group. The study enrolled 170 HER2-enriched subtype breast cancer patients with 5-year disease free survival (DFS) of 85.1% and 5-year overall survival (OS) of 86.8%. Prognostic stages of 117 cases (68.8%) changed compared with anatomic stages, with 116 upstaged cases and 1 downstaged case. The Anatomic Stage Groups had a significant prognostic impact on DFS (χ 2 =16.752, panalysis, both stage groups were independent predictors of OS. Both Anatomic and Prognostic Stage Groups in the 8th edition of the AJCC breast cancer staging system had prognostic value in HER2-enriched subtype breast cancer. The Prognostic Stage system was a breakthrough on the basis of anatomic staging system. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  5. A two-stage approach for multi-objective decision making with applications to system reliability optimization

    International Nuclear Information System (INIS)

    Li Zhaojun; Liao Haitao; Coit, David W.

    2009-01-01

    This paper proposes a two-stage approach for solving multi-objective system reliability optimization problems. In this approach, a Pareto optimal solution set is initially identified at the first stage by applying a multiple objective evolutionary algorithm (MOEA). Quite often there are a large number of Pareto optimal solutions, and it is difficult, if not impossible, to effectively choose the representative solutions for the overall problem. To overcome this challenge, an integrated multiple objective selection optimization (MOSO) method is utilized at the second stage. Specifically, a self-organizing map (SOM), with the capability of preserving the topology of the data, is applied first to classify those Pareto optimal solutions into several clusters with similar properties. Then, within each cluster, the data envelopment analysis (DEA) is performed, by comparing the relative efficiency of those solutions, to determine the final representative solutions for the overall problem. Through this sequential solution identification and pruning process, the final recommended solutions to the multi-objective system reliability optimization problem can be easily determined in a more systematic and meaningful way.

  6. Dynamic analysis of the CRBRP clean-up system (three stage aqueous scrubber)

    International Nuclear Information System (INIS)

    Kyi, R.; Bijlani, C.; Fazekas, P.; Dajani, A.

    1981-01-01

    The CRBRP containment clean-up system design required the determination of the thermal-hydraulic performance of the system during its projected operating cycle. The reduced scale component tests at HEDL provided valuable information about the generic performance of the components; however, due to the limitations of the test facility the exact simulation of the actual CRBRP conditions was not feasible. A computer program was developed to permit dynamic system analysis of the full size air cleaning system. The dynamic system analysis considered the mass and energy balances across each component. In addition to the major filtration system components, the system modeling included the supporting fluid system components such as pumps, tanks and heat exchangers. Variable gas flow, temperature, chemical concentrations, and other system parameters were also modeled. Fission product heat, chemical reaction heat and heat of solution were considered. The analysis results provided sodium hydroxide solution concentrations and temperatures, gas temperatures and other variables at the various components within the air cleaning system for each calculated time interval. The accuracy of the computer modeling was verified by comparing the calculated results with HEDL test data. The comparison indicated a better than +-10% agreement with the test data. The analysis results provided the basis for the selection of the system components

  7. Sleep-stage scoring in mice: The influence of data pre-processing on a system's performance.

    Science.gov (United States)

    Katsageorgiou, Vasiliki-Maria; Lassi, Glenda; Tucci, Valter; Murino, Vittorio; Sona, Diego

    2015-08-01

    Sleep-stage analysis in mice and rats has received growing attention in recent years, due to the fact that mice display electrical activity during sleep which has underlying similarities with that of human sleep. Both conventional manual and automatic sleep-wakefulness scoring are rule based tasks which use brain waves measured by Electroencephalogram (EEG) and activity detected by Electromyography (EMG) of skeletal muscles. Several works have been conducted trying to provide an automatic sleep-scoring system on the basis of machine learning methods. In this study we try to understand the reasons behind the complexity of this problem and we emphasize the importance of normalization procedure that leads to a better stage discrimination comparing different classification methods.

  8. Post-treatment of secondary wastewater treatment plant effluent using a two-stage fluidized bed bioreactor system.

    Science.gov (United States)

    Safari, Golam Hossein; Yetilmezsoy, Kaan; Mahvi, Amir Hossein; Zarrabi, Mansur

    2013-06-17

    The aim of this study was to investigate the performance of a two-stage fluidized bed reactor (FBR) system for the post-treatment of secondary wastewater treatment plant effluents (Shahrak Gharb, Tehran, Iran). The proposed treatment scheme was evaluated using pilot-scale reactors (106-L of capacity) filled with PVC as the fluidized bed (first stage) and gravel for the filtration purpose (second stage). Aluminum sulfate (30 mg/L) and chlorine (1 mg/L) were used for the coagulation and disinfection of the effluent, respectively. To monitor the performance of the FBR system, variation of several parameters (biochemical oxygen demand (BOD5), chemical oxygen demand (COD), turbidity, total phosphorous, total coliform and fecal coliform) were monitored in the effluent wastewater samples. The results showed that the proposed system could effectively reduce BOD5 and COD below 1.95 and 4.06 mg/L, respectively. Turbidity of the effluent could be achieved below 0.75 NTU, which was lower than those reported for the disinfection purpose. The total phosphorus was reduced to 0.52 mg/L, which was near the present phosphorous standard for the prevention of eutrophication process. Depending on both microorganism concentration and applied surface loading rates (5-10 m/h), about 35 to 75% and 67 to 97% of coliform were removed without and with the chlorine addition, respectively. Findings of this study clearly confirmed the efficiency of the FBR system for the post-treatment of the secondary wastewater treatment plant effluents without any solid problem during the chlorination.

  9. Post-Treatment of Secondary Wastewater Treatment Plant Effluent Using A Two-Stage Fluidized Bed Bioreactor System

    Directory of Open Access Journals (Sweden)

    Golam Hossein Safari

    2013-06-01

    Full Text Available The aim of this study was to investigate the performance of a two-stage fluidized bed reactor (FBR system for the post-treatment of secondary wastewater treatment plant effluents (Shahrak Gharb, Tehran, Iran. The proposed treatment scheme was evaluated using pilot-scale reactors (106-L of capacity filled with PVC as the fluidized bed (first stage and gravel for the filtration purpose (second stage. Aluminum sulfate (30 mg/L and chlorine (1 mg/L were used for the coagulation and disinfection of the effluent, respectively. To monitor the performance of the FBR system, variation of several parameters (biochemical oxygen demand (BOD5, chemical oxygen demand (COD, turbidity, total phosphorous, total coliform and fecal coliform were monitored in the effluent wastewater samples. The results showed that the proposed system could effectively reduce BOD5 and COD below 1.95 and 4.06 mg/L, respectively. Turbidity of the effluent could be achieved below 0.75 NTU, which was lower than those reported for the disinfection purpose. The total phosphorus was reduced to 0.52 mg/L, which was near the present phosphorous standard for the prevention of eutrophication process. Depending on both microorganism concentration and applied surface loading rates (5–10 m/h, about 35 to 75% and 67 to 97% of coliform were removed without and with the chlorine addition, respectively. Findings of this study clearly confirmed the efficiency of the FBR system for the post-treatment of the secondary wastewater treatment plant effluents without any solid problem during the chlorination.

  10. Reward and motivation systems: a brain mapping study of early-stage intense romantic love in Chinese participants.

    Science.gov (United States)

    Xu, Xiaomeng; Aron, Arthur; Brown, Lucy; Cao, Guikang; Feng, Tingyong; Weng, Xuchu

    2011-02-01

    Early-stage romantic love has been studied previously in the United States and United Kingdom (Aron et al. [2005]: J Neurophysiol 94:327–337; Bartels and Zeki [2000]: Neuroreport 11:3829–3834; Ortigue et al. [2007]: J Cogn Neurosci 19:1218–1230), revealing activation in the reward and motivation systems of the brain. In this study, we asked what systems are activated for early-stage romantic love in Easterners, specifically Chinese participants? Are these activations affected by individual differences within a cultural context of Traditionality and Modernity? Also, are these brain activations correlated with later satisfaction in the relationship? In Beijing, we used the same procedure used by Aron et al. (Aron et al. [2005]: J Neurophysiol 94:327–337). The stimuli for 18 Chinese participants were a picture of the face of their beloved, the face of a familiar acquaintance, and a countback task. We found significant activations specific to the beloved in the reward and motivation systems, particularly, the ventral tegmental area and the caudate. The mid-orbitofrontal cortex and cerebellum were also activated, whereas amygdala, medial orbitofrontal, and medial accumbens activity were decreased relative to the familiar acquaintance. Self-reported Traditionality and Modernity scores were each positively correlated with activity in the nucleus accumbens, although in different regions and sides of the brain. Activity in the subgenual area and the superior frontal gyrus was associated with higher relationship happiness at 18-month follow-up. Our results show that midbrain dopamine-rich reward/motivation systems were activated by early-stage romantic love in Chinese participants, as found by other studies. Neural activity was associated with Traditionality and Modernity attitudes as well as with later relationship happiness for Chinese participants.

  11. Dynamic solar-powered multi-stage direct contact membrane distillation system: Concept design, modeling and simulation

    KAUST Repository

    Lee, Jung Gil

    2017-04-26

    This paper presents a theoretical analysis of the monthly average daily and hourly performances of a solar-powered multi-stage direct contact membrane distillation (SMDCMD) system with an energy recovery scheme and dynamic operating system. Mid-latitude meteorological data from Busan, Korea is employed, featuring large climate variation over the course of one year. The number of module stages used by the dynamic operating scheme changes dynamically based on the inlet feed temperature of the successive modules, which results in an improvement of the water production and thermal efficiency. The simulations of the SMDCMD system are carried out to investigate the spatial and temporal variations in the feed and permeate temperatures and permeate flux. The monthly average daily water production increases from 0.37m3/day to 0.4m3/day and thermal efficiency increases from 31% to 45% when comparing systems both without and with dynamic operation in December. The water production with respect to collector area ranged from 350m2 to 550m2 and the seawater storage tank volume ranged from 16m3 to 28.8m3, and the solar fraction at various desired feed temperatures from 50°C to 80°C have been investigated in October and December.

  12. Prognostic Impact of the 6th and 7th American Joint Committee on Cancer TNM Staging Systems on Esophageal Cancer Patients Treated With Chemoradiotherapy

    International Nuclear Information System (INIS)

    Nomura, Motoo; Shitara, Kohei; Kodaira, Takeshi; Hatooka, Shunzo; Mizota, Ayako; Kondoh, Chihiro; Yokota, Tomoya; Takahari, Daisuke; Ura, Takashi; Muro, Kei

    2012-01-01

    Purpose: The new 7th edition of the American Joint Committee on Cancer TNM staging system is based on pathologic data from esophageal cancers treated by surgery alone. There is no information available on evaluation of the new staging system with regard to prognosis of patients treated with chemoradiotherapy (CRT). The objective of this study was to evaluate the prognostic impact of the new staging system on esophageal cancer patients treated with CRT. Methods and Materials: A retrospective review was performed on 301 consecutive esophageal squamous cell carcinoma patients treated with CRT. Comparisons were made of the prognostic impacts of the 6th and 7th staging systems and the prognostic impacts of stage and prognostic groups, which were newly defined in the 7th edition. Results: There were significant differences between Stages I and III (p < 0.01) according to both editions. However, the 7th edition poorly distinguishes the prognoses of Stages III and IV (p = 0.36 by multivariate analysis) in comparison to the 6th edition (p = 0.08 by multivariate analysis), although these differences were not significant. For all patients, T, M, and gender were independent prognostic factors by multivariate analysis (p < 0.05). For the Stage I and II prognostic groups, survival curves showed a stepwise decrease with increase in stage, except for Stage IIA. However, there were no significant differences seen between each prognostic stage. Conclusions: Our study indicates there are several problems with the 7th TNM staging system regarding prognostic factors in patients undergoing CRT.

  13. 77 FR 67449 - Medicare Program; End-Stage Renal Disease Prospective Payment System, Quality Incentive Program...

    Science.gov (United States)

    2012-11-09

    ... (ESRD) prospective payment system (PPS) for calendar year (CY) 2013. This rule also sets forth... Disease (ESRD) Prospective Payment System (PPS) 2. ESRD QIP 3. Reductions to Bad Debt Payments for All... Major Provisions 1. ESRD PPS 2. ESRD QIP 3. Reductions to Bad Debt Payments for All Medicare Providers...

  14. Dynamic multi-stage dispatch of isolated wind–diesel power systems

    DEFF Research Database (Denmark)

    Hu, Yu; Morales González, Juan Miguel; Pineda, Salvador

    2015-01-01

    An optimal dispatch strategy is crucial for an isolated wind–diesel power system to save diesel fuel and maintain the system stability. The uncertainty associated with the stochastic character of the wind is, though, a challenging problem for this optimization. In this paper, a dynamic multi-stag...

  15. Single-stage quintuplet for upgrading triplet based lens system: Simulation for Atomki microprobe

    Science.gov (United States)

    Ponomarov, Artem; Rajta, Istvan; Nagy, Gyula; Romanenko, Oleksandr V.

    2017-08-01

    Among different configurations of lens systems for nuclear microprobes, the most common one is a triplet of magnetic quadrupole lenses. Nowadays, microanalysis and material modification will undoubtedly benefit from an improvement in spatial resolution. This work presents the results of simulations for improvement of the Oxford Triplet lens system at the Atomki microprobe with consideration of its system parameters and measured beam brightness distribution. For this purpose, an additional single-unit doublet of lenses with two power supplies was introduced. Using earlier developed methods, such a quintuplet system was optimized in order to determine the parameters which provided the highest resolution for different current operational modes with the same microprobe geometry. The tolerances for lens positioning accuracy were also calculated. The obtained quintuplet parameters indicate a resolution improvement for the Atomki microprobe compared to the Oxford Triplet system and these results validate further experimental testing of the proposed quintuplet.

  16. Multiple risk expert systems interventions: impact of simultaneous stage-matched expert system interventions for smoking, high-fat diet, and sun exposure in a population of parents.

    Science.gov (United States)

    Prochaska, James O; Velicer, Wayne F; Rossi, Joseph S; Redding, Colleen A; Greene, Geoffrey W; Rossi, Susan R; Sun, Xiaowu; Fava, Joseph L; Laforge, Robert; Plummer, Brett A

    2004-09-01

    Three stage-based expert system interventions for smoking, high-fat diet, and unsafe sun exposure were evaluated in a sample of 2,460 parents of teenagers. Eighty-four percent of the eligible parents were enrolled in a 2-arm randomized control trial, with the treatment group receiving individualized feedback reports for each of their relevant behaviors at 0, 6, and 12 months as well as a multiple behavior manual. At 24 months, the expert system outperformed the comparison condition across all 3 risk behaviors, resulting in 22% of the participants in action or maintenance for smoking (vs. 16% for the comparison condition), 34% for diet (vs. 26%), and 30% for sun exposure (vs. 22%). Proactive, home-based, and stage-matched expert systems can produce significant multiple behavior changes in at-risk populations where the majority of participants are not prepared to change. ((c) 2004 APA, all rights reserved)

  17. Judicial Reform of the 1864 as a Stage of Russian Judicial System Democratic Development

    Directory of Open Access Journals (Sweden)

    Lyubov F. Miloserdova

    2014-03-01

    Full Text Available In the present article, author considers the place of judicial reform of 1864 in the public and social reforms of Alexander II. This paper attempts to show the place of justice in the legal system of Russian Empire in the post-reform period. Author emphasizes democratic and progressive nature of judicial reform of 1864, noting lack of preconditions for the formation of democratic judicial system under the autocracy. Author analyzes relationship and development of the judicial system and the dynamics of social relations. Author also revealed the way of judicial system in the formation of civil society prerequisites. This paper attempts to show and prove that judicial reform is actually a first step towards the formation of the Russian system of powers separation. Author concludes that undertaken by the Government of Russian Empire in the mid-nineteenth century attempt of the Russian Empire judicial system democratization had neither political nor social assumptions. In conclusion, author concludes that in the present conditions of judicial system democratization in modern Russian Federation a number of principles and institutions of judicial reform of 1864 was applied.

  18. Comparative overview of primary sedimentation-based mechanical stage in some Romanian wastewater treatment systems

    Science.gov (United States)

    Zaharia, C.

    2017-08-01

    Nowadays, wastewater (WW) treatment facilities are considered significant exposure pathways for solid particles, and also significant concerns of any quality conscious manufacturer. Most solid particles have some forms of organic coating either used as active material or to suspend and/or stabilize different present solid materials, having increase in toxicity that must be reduced, or sometimes even totally eliminated, especially if effluent is either discharged directly to surface water, or distributed through industrial water supplies. Representatives providing innovative technologies, comprehensive supports and expertise in wastewater and sludge treatment field are known, each one using modern treatment technology and facilities. Mechanical treatment is indispensable in primary treatment steps of both municipal and industrial WW applications, its main goal being separation of floating, settling and suspended materials (especially into a primary sedimentation-based treatment step). The aim of this work is to present comparatively the performance in solids removal of conventional mechanical WW treatment stages, especially those based on primary sedimentation, or sedimentation-like operations applied for Romanian urban WW treatment plants (serving two towns with ca 18,000 inhabitants), industrial WW treatment plants (deserving industries of vegetal food processing and organic chemicals’ manufacturing) and additional information on valorisation of separated solid material and improvement possibilities.

  19. Clinical significance of a proposed lymphoscintigrpahic functional grade system in patients with extremity lymphedema of stage i

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Joan Young; Hwang, Ji Hye; Kim, Dong Ik; Cho, Young Seok; Lee, Su Jin; Choi, Yong; Choe, Yeam Seong; Lee, Kyung Han; Kim, Byung Tae [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2005-07-01

    We proposed a new lymphoscintigrpahic functional grade (LGr) system in extremity lymphedema, and investigated the association between the LGr and a long-term response to physical therapy in patients with extremity lymphedema of stage I. The subjects were 20 patients with unilateral extremity lymphedema of stage I, who underwent pre-treatment extremity lymphoscintigraphy using Tc-99m antimony sulfur colloid, and were treated by complex decongestive physical therapy (CDPT). A proposed lymphoscintigrpahic functional grade system consisted of LGr 0 to LGr 4 according to the ilioinguinal nodal uptake, amount of dermal backflow, and uptake pattern of main and collateral lymphatics : LGr 0 = normal, LGr 1 = decreased lymphatic function without dermal backflow, LGr 2 = decreased lymphatic function with dermal backflow, LGr 3 = non - visualization of main lymphatics with dermal backflow, and LGr 4 = no significant lymphatic transport from injection site. LGr 2 was divided into 2A and 2B based on the amount of dermal backflow. A physician who is a lymphedema specialist determined the long-term outcome to CDPT with normalized response (NR), good response (GR) and poor response (PR) based on the change of edema volume reduction, skin status and occurrence of dermatolymphangioadenitis after the clinical follow-up for more than 1 year. Therapeutic responses were NR in 2 patients. GR in 9 patients and PR in 9 patients. Baseline LGrs were 1 in 7 patients, 2A in 4 patients, 2B in 5 patients, 3 in 2 patients, and 4 in 2 patients. There was a significant relationship between therapeutic response and LGr (p=0.003). In other words, 10 of 11 patients (91%) with LGr 1 or 2A showed NR. or GR. On the contrary, 8 of 9 patients (89%) with LGr 2B, 3 or 4 showed PR. Patients with unilateral extremity lymphedema of stage I had different lymphoscintigrpahic functional grades. This grade system may be useful to predict the response to physical therapy in such patients.

  20. New York State energy-analytic information system: first-stage implementation

    Energy Technology Data Exchange (ETDEWEB)

    Allentuck, J.; Carroll, O.; Fiore, L.

    1979-09-01

    So that energy policy by state government may be formulated within the constraints imposed by policy determined at the national level - yet reflect the diverse interests of its citizens - large quantities of data and sophisticated analytic capabilities are required. This report presents the design of an energy-information/analytic system for New York State, the data for a base year, 1976, and projections of these data. At the county level, 1976 energy-supply demand data and electric generating plant data are provided as well. Data-base management is based on System 2000. Three computerized models provide the system's basic analytic capacity. The Brookhaven Energy System Network Simulator provides an integrating framework while a price-response model and a weather sensitive energy demand model furnished a short-term energy response estimation capability. The operation of these computerized models is described. 62 references, 25 figures, 39 tables.

  1. FNL Scientists Introduce Concept That Could Help the Immune System Respond to Vaccines | FNLCR Staging

    Science.gov (United States)

    Scientists have discovered an efficient and straightforward model to manipulate RNA nanoparticles, a new concept that could help trigger desirable activation of the immune system with vaccines and therapies. A multi-institutional team of researchers

  2. Palm oil mill effluent treatment using a two-stage microbial fuel cells system integrated with immobilized biological aerated filters.

    Science.gov (United States)

    Cheng, Jia; Zhu, Xiuping; Ni, Jinren; Borthwick, Alistair

    2010-04-01

    An integrated system of two-stage microbial fuel cells (MFCs) and immobilized biological aerated filters (I-BAFs) was used to treat palm oil mill effluent (POME) at laboratory scale. By replacing the conventional two-stage up-flow anaerobic sludge blanket (UASB) with a newly proposed upflow membrane-less microbial fuel cell (UML-MFC) in the integrated system, significant improvements on NH(3)-N removal were observed and direct electricity generation implemented in both MFC1 and MFC2. Moreover, the coupled iron-carbon micro-electrolysis in the cathode of MFC2 further enhanced treatment efficiency of organic compounds. The I-BAFs played a major role in further removal of NH(3)-N and COD. For influent COD and NH(3)-N of 10,000 and 125 mg/L, respectively, the final effluents COD and NH(3)-N were below 350 and 8 mg/L, with removal rates higher than 96.5% and 93.6%. The GC-MS analysis indicated that most of the contaminants were satisfactorily biodegraded by the integrated system. Copyright 2009 Elsevier Ltd. All rights reserved.

  3. A Study of a Two Stage Maximum Power Point Tracking Control of a Photovoltaic System under Partially Shaded Insolation Conditions

    Science.gov (United States)

    Kobayashi, Kenji; Takano, Ichiro; Sawada, Yoshio

    A photovoltaic array shows relatively low output power density, and has a greatly drooping Current-Voltage (I-V) characteristic. Therefore, Maximum Power Point Tracking (MPPT) control is used to maximize the output power of the array. Many papers have been reported in relation to MPPT. However, the Current-Power (I-P) curve sometimes shows multi-local maximum points mode under non-uniform insolation conditions. The operating point of the PV system tends to converge to a local maximum output point which is not the real maximal output point on the I-P curve. Some papers have been also reported, trying to avoid this difficulty. However most of those control systems become rather complicated. Then, the two stage MPPT control method is proposed in this paper to realize a relatively simple control system which can track the real maximum power point even under non-uniform insolation conditions. The feasibility of this control concept is confirmed for steady insolation as well as for rapidly changing insolation by simulation study using software PSIM and LabVIEW. In addition, simulated experiment confirms fundament al operation of the two stage MPPT control.

  4. Research on the Power Recovery of Diesel Engines with Regulated Two-Stage Turbocharging System at Different Altitudes

    Directory of Open Access Journals (Sweden)

    Hualei Li

    2014-01-01

    Full Text Available Recovering the boost pressure is very important in improving the dynamic performance of diesel engines at high altitudes. A regulated two-stage turbocharging system is an adequate solution for power recovery of diesel engines. In the present study, the change of boost pressure and engine power at different altitudes was investigated, and a regulated two-stage turbocharging system was constructed with an original turbocharger and a matched low pressure turbocharger. The valve control strategies for boost pressure recovery, which formed the basis of the power recovery method, are presented here. The simulation results showed that this system was effective in recovering the boost pressure at different speeds and various altitudes. The turbine bypass valve and compressor bypass valve had different modes to adapt to changes in operating conditions. The boost pressure recovery could not ensure power recovery over the entire operating range of the diesel engine, because of variation in overall turbocharger efficiency. The fuel-injection compensation method along with the valve control strategies for boost pressure recovery was able to reach the power recovery target.

  5. The second stage of long-term training in team games: experimental assessment of traditional training system

    Directory of Open Access Journals (Sweden)

    Maksimenko I.G

    2010-03-01

    Full Text Available The features of construction of the traditional system of preparation of young sportsmen are certain on the stage of the preliminary base training. In researches 200 players took part in age 12-15 years. The indexes of frequency of cardiac rhythm, expenses of energy, competition activity of young sportsmen are presented. Indexes are fixed during implementation of the different typical trainings programs, participating in bilateral and official games. The typical rations of feed are analysed. The results of deep medical inspection are rotined.

  6. Tubular gage for a liquid-metal-cooled fast breeder reactor

    International Nuclear Information System (INIS)

    Hutter, E.; Tuma, L.A.

    1977-01-01

    Spring-loaded plungers are arranged about a housing for insertion into a polygonal tube, one plunger for each side of the tube. Each plunger has a locking cam and sliding wedge mechanism which can overcome the spring force associated with the plunger and lock it in any position. The wedges are operated by a rod movable axially in the housing. Several housings with their associated plungers can be stacked. The stack is lowered into the polygonal tube with all of the plungers locked in a fully inward position. When the stack is in the tube, each wedge is moved to release its locking cam, allowing each of the plungers to spring outward against an inner side of the tube. Each housing will thus gage the internal dimensions of the tube at its elevation. The plungers are locked in position, the entire stack is rotated to bring the plungers into the corners described by the intersections of the flat sides, and the stack is removed from the tube whereupon the dimensions across opposite locked plungers may be read by a micrometer

  7. Flight Test Results from the Rake Airflow Gage Experiment on the F-15B Airplane

    Science.gov (United States)

    Frederick, Michael A.; Ratnayake, Nalin A.

    2011-01-01

    The Rake Airflow Gage Experiment involves a flow-field survey rake that was flown on the Propulsion Flight Test Fixture at the NASA Dryden Flight Research Center using the Dryden F-15B research test bed airplane. The objective of this flight test was to ascertain the flow-field angularity, local Mach number profile, total pressure distortion, and dynamic pressure at the aerodynamic interface plane of the Channeled Centerbody Inlet Experiment. This new mixed-compression, supersonic inlet is planned for flight test in the near term. Knowledge of the flow-field characteristics at this location underneath the airplane is essential to flight test planning and computational modeling of the new inlet, anairplane, flying at a free-stream Mach number of 1.65 and a pressure altitude of 40,000 ft, would achieve the desired local Mach number for the future inlet flight test. Interface plane distortion levels of 2 percent and a local angle of attack of -2 deg were observed at this condition. Alternative flight conditions for future testing and an exploration of certain anomalous data also are provided.

  8. Mehanical Properties of Electron Beam Welded Joints in Thick Gage CA6NM Stainless Steel

    Science.gov (United States)

    Sarafan, Sheida; Wanjara, Priti; Gholipour, Javad; Champliaud, Henri; Mathieu, Louis

    2017-10-01

    Design of hydroelectric turbine components requires high integrity welds (without detectable volumetric defects) in heavy gage sections of stainless steel materials, such as ASTM A743 grade CA6NM—a low carbon 13% Cr-4% Ni martensitic stainless steel that is manufactured in cast form. In this work, 90-mm-thick plates of CA6NM were joined using a single-pass autogenous electron beam (EB) welding process and the mechanical properties were evaluated in the as-welded condition to characterize the performance of the joints. The static tensile properties that were evaluated in two directions—transverse and longitudinal to the EB weld seam—demonstrated conformance of the joints with the requirements of the ASME Section IX standard. The Charpy impact energies of the EB welds—measured at -18 °C on samples with V-notch roots located in the fusion and heat-affected zones—met the minimum requirements of 27 J specified in ASME Section VIII standard. In addition, bend tests that were conducted on the entire weld cross section displayed no discontinuities on the tension side of the bent joints. Hence, the developed EB welding process was demonstrated to render high-performance joints and promises key advantages for industrialization, such as cost savings through reductions in consumable material, production time and labor intensity.

  9. Flexible Riser Monitoring Using Hybrid Magnetic/Optical Strain Gage Techniques through RLS Adaptive Filtering

    Science.gov (United States)

    Pipa, Daniel; Morikawa, Sérgio; Pires, Gustavo; Camerini, Claudio; Santos, JoãoMárcio

    2010-12-01

    Flexible riser is a class of flexible pipes which is used to connect subsea pipelines to floating offshore installations, such as FPSOs (floating production/storage/off-loading unit) and SS (semisubmersible) platforms, in oil and gas production. Flexible risers are multilayered pipes typically comprising an inner flexible metal carcass surrounded by polymer layers and spiral wound steel ligaments, also referred to as armor wires. Since these armor wires are made of steel, their magnetic properties are sensitive to the stress they are subjected to. By measuring their magnetic properties in a nonintrusive manner, it is possible to compare the stress in the armor wires, thus allowing the identification of damaged ones. However, one encounters several sources of noise when measuring electromagnetic properties contactlessly, such as movement between specimen and probe, and magnetic noise. This paper describes the development of a new technique for automatic monitoring of armor layers of flexible risers. The proposed approach aims to minimize these current uncertainties by combining electromagnetic measurements with optical strain gage data through a recursive least squares (RLSs) adaptive filter.

  10. Flexible Riser Monitoring Using Hybrid Magnetic/Optical Strain Gage Techniques through RLS Adaptive Filtering

    Directory of Open Access Journals (Sweden)

    Pipa Daniel

    2010-01-01

    Full Text Available Flexible riser is a class of flexible pipes which is used to connect subsea pipelines to floating offshore installations, such as FPSOs (floating production/storage/off-loading unit and SS (semisubmersible platforms, in oil and gas production. Flexible risers are multilayered pipes typically comprising an inner flexible metal carcass surrounded by polymer layers and spiral wound steel ligaments, also referred to as armor wires. Since these armor wires are made of steel, their magnetic properties are sensitive to the stress they are subjected to. By measuring their magnetic properties in a nonintrusive manner, it is possible to compare the stress in the armor wires, thus allowing the identification of damaged ones. However, one encounters several sources of noise when measuring electromagnetic properties contactlessly, such as movement between specimen and probe, and magnetic noise. This paper describes the development of a new technique for automatic monitoring of armor layers of flexible risers. The proposed approach aims to minimize these current uncertainties by combining electromagnetic measurements with optical strain gage data through a recursive least squares (RLSs adaptive filter.

  11. A Multi-Gage Calibration Approach for Modeling a Semiarid Santa Cruz watershed in Arizona-Mexico Border

    Science.gov (United States)

    Niraula, R.; Meixner, T.; Norman, L. M.

    2011-12-01

    Flow at the outlet does not sufficiently represent underlying processes for an entire watershed in semiarid climates, where the flow from much of the catchment may not reach the outlet most of the time. For modeling these watersheds, calibration to discharge is required not only at the watershed outlet but also in various locations within the watershed to best capture real watershed conditions. The objective of this study is to develop a reliable model for the Santa Cruz watershed to analyze the impact of land use and climate change on hydrology and water quality in this semiarid basin. The semiarid Santa Cruz watershed (Lat:34oN and Long:-111oW) is 9,000 km2 and located in southern Arizona, United States (85%) and northern Sonora, Mexico (15%). In this study, the Soil and Water Assessment Tool (SWAT) was used to calibrate the flow at seven monitoring stations to increase the reliability of flow and therefore water quality predictions for the entire basin. The model performance was evaluated based on observed hydrograph, Mass balance error (MBE) coefficient of determination (R2) and Nash-Sutcliffe efficiency (NSE). We began the calibration by identifying the most sensitive parameters using the Latin hypercube global sensitivity approach, identifying that the baseflow recession coefficient, the effective hydraulic conductivity in main channel (transmission loss), the curve number and the soil evaporation compensation factor as the most sensitive parameters. Next, we manually calibrated the model at the USGS gage near the outlet by modifying these parameters. Although the model was validated well at the outlet, the model was not able to validate the flow at other USGS gages inside the watershed. Thus we calibrated the model in sequential order from upstream to downstream gages by further adjusting these parameters. A significant amount of water is lost through transmission loss in our modeling of the Santa Cruz. In SWAT, by default the loss from the streambed is set

  12. Wind power integration studies using a multi-stage stochastic electricity system model

    DEFF Research Database (Denmark)

    Meibom, Peter; Barth, R.; Brand, H.

    2007-01-01

    A large share of integrated wind power causes technical and financial impacts on the operation of the existing electricity system due to the fluctuating behaviour and unpredictability of wind power. The presented stochastic electricity market model optimises the unit commitment considering four...... kinds of electricity markets (e.g. a spot and balancing market) and taking into account the stochastic behaviour of the wind power generation and of the prediction error. It can be used for the evaluation of varying electricity prices and system costs due to wind power integration...

  13. Biomechanical stress maps of an artificial femur obtained using a new infrared thermography technique validated by strain gages.

    Science.gov (United States)

    Shah, Suraj; Bougherara, Habiba; Schemitsch, Emil H; Zdero, Rad

    2012-12-01

    Femurs are the heaviest, longest, and strongest long bones in the human body and are routinely subjected to cyclic forces. Strain gages are commonly employed to experimentally validate finite element models of the femur in order to generate 3D stresses, yet there is little information on a relatively new infrared (IR) thermography technique now available for biomechanics applications. In this study, IR thermography validated with strain gages was used to measure the principal stresses in the artificial femur model from Sawbones (Vashon, WA, USA) increasingly being used for biomechanical research. The femur was instrumented with rosette strain gages and mechanically tested using average axial cyclic forces of 1500 N, 1800 N, and 2100 N, representing 3 times body weight for a 50 kg, 60 kg, and 70 kg person. The femur was oriented at 7° of adduction to simulate the single-legged stance phase of walking. Stress maps were also obtained using an IR thermography camera. Results showed good agreement of IR thermography vs. strain gage data with a correlation of R(2)=0.99 and a slope=1.08 for the straight line of best fit. IR thermography detected the highest principal stresses on the superior-posterior side of the neck, which yielded compressive values of -91.2 MPa (at 1500 N), -96.0 MPa (at 1800 N), and -103.5 MPa (at 2100 N). There was excellent correlation between IR thermography principal stress vs. axial cyclic force at 6 locations on the femur on the lateral (R(2)=0.89-0.99), anterior (R(2)=0.87-0.99), and posterior (R(2)=0.81-0.99) sides. This study shows IR thermography's potential for future biomechanical applications. Copyright © 2012 IPEM. Published by Elsevier Ltd. All rights reserved.

  14. System implementation: managing project and post project stage - case study in an Indonesian company

    NARCIS (Netherlands)

    Govindaraju, Rajesri; de Bruijn, E.J.; Fisscher, O.A.M.; Laptaned, U

    2007-01-01

    The research reported in this paper aims to get a better understanding of how the implementation process of enterprise systems (ES) can be managed, by studying the process from an organisational perspective. A review of the literature on previous research in ES implementation has been carried out

  15. Structuring the analysis of human concerns at an early stage of system development

    NARCIS (Netherlands)

    Belyavin, A.J.; Tyler, S.; Lotens, W.A.

    2011-01-01

    This paper describes the development of a new approach to risk analysis applied to the investigation of how inserting new technologies in systems may induce positive and negative human impacts. The current approach employed by the UK Ministry of Defence, and embodied in the Early Human Factors

  16. Sensorless Reserved Power Control Strategy for Two-Stage Grid-Connected Photovoltaic Systems

    DEFF Research Database (Denmark)

    Sangwongwanich, Ariya; Yang, Yongheng; Blaabjerg, Frede

    2016-01-01

    Due to still increasing penetration level of grid-connected Photovoltaic (PV) systems, advanced active power control functionalities have been introduced in grid regulations. A reserved power control, where the active power from the PV panels is reserved during operation, is required for grid...

  17. Three-stage enzymatic digestive system for a gut-on-a-chip

    NARCIS (Netherlands)

    de Haan, Pim; Ianovska, Margaryta A.; Bouwmeester, Hans; Verpoorte, Elisabeth

    2017-01-01

    Several different devices to model the human gastrointestinal (GI) tract have been developed, which may find applications as pharmacological or toxicological model systems.1 To create a fully functional gut-on-a-chip, it is essential to incorporate the digestive functions of the GI tract into such a

  18. Artificial immune system and sheep flock algorithms for two-stage fixed-charge transportation problem

    DEFF Research Database (Denmark)

    Kannan, Devika; Govindan, Kannan; Soleimani, Hamed

    2014-01-01

    approaches are unable to solve real-world instances of such NP-hard problems in a reasonable time. These approaches involve cumbersome computational steps in real-size cases. In order to solve the mixed integer linear programming model, we develop an artificial immune system and a sheep flock algorithm...

  19. Two-Stage Battery Energy Storage System (BESS in AC Microgrids with Balanced State-of-Charge and Guaranteed Small-Signal Stability

    Directory of Open Access Journals (Sweden)

    Bing Xie

    2018-02-01

    Full Text Available In this paper, a two-stage battery energy storage system (BESS is implemented to enhance the operation condition of conventional battery storage systems in a microgrid. Particularly, the designed BESS is composed of two stages, i.e., Stage I: integration of dispersed energy storage units (ESUs using parallel DC/DC converters, and Stage II: aggregated ESUs in grid-connected operation. Different from a conventional BESS consisting of a battery management system (BMS and power conditioning system (PCS, the developed two-stage architecture enables additional operation and control flexibility in balancing the state-of-charge (SoC of each ESU and ensures the guaranteed small-signal stability, especially in extremely weak grid conditions. The above benefits are achieved by separating the control functions between the two stages. In Stage I, a localized power sharing scheme based on the SoC of each particular ESU is developed to manage the SoC and avoid over-charge or over-discharge issues; on the other hand, in Stage II, an additional virtual impedance loop is implemented in the grid-interactive DC/AC inverters to enhance the stability margin with multiple parallel-connected inverters integrating at the point of common coupling (PCC simultaneously. A simulation model based on MATLAB/Simulink is established, and simulation results verify the effectiveness of the proposed BESS architecture and the corresponding control diagram.

  20. Pipelining Computational Stages of the Tomographic Reconstructor for Multi-Object Adaptive Optics on a Multi-GPU System

    KAUST Repository

    Charara, Ali

    2014-11-01

    The European Extremely Large Telescope project (E-ELT) is one of Europe\\'s highest priorities in ground-based astronomy. ELTs are built on top of a variety of highly sensitive and critical astronomical instruments. In particular, a new instrument called MOSAIC has been proposed to perform multi-object spectroscopy using the Multi-Object Adaptive Optics (MOAO) technique. The core implementation of the simulation lies in the intensive computation of a tomographic reconstruct or (TR), which is used to drive the deformable mirror in real time from the measurements. A new numerical algorithm is proposed (1) to capture the actual experimental noise and (2) to substantially speed up previous implementations by exposing more concurrency, while reducing the number of floating-point operations. Based on the Matrices Over Runtime System at Exascale numerical library (MORSE), a dynamic scheduler drives all computational stages of the tomographic reconstruct or simulation and allows to pipeline and to run tasks out-of order across different stages on heterogeneous systems, while ensuring data coherency and dependencies. The proposed TR simulation outperforms asymptotically previous state-of-the-art implementations up to 13-fold speedup. At more than 50000 unknowns, this appears to be the largest-scale AO problem submitted to computation, to date, and opens new research directions for extreme scale AO simulations. © 2014 IEEE.

  1. Older Adults' Perceptions of and Preferences for a Fall Risk Assessment System: Exploring Stages of Acceptance Model.

    Science.gov (United States)

    Galambos, Colleen; Rantz, Marilyn; Back, Jessie; Jun, Jung Sim; Skubic, Marjorie; Miller, Steven J

    2017-07-01

    Aging in place is a preferred and cost-effective living option for older adults. Research indicates that technology can assist with this goal. Information on consumer preferences will help in technology development to assist older adults to age in place. The study aim was to explore the perceptions and preferences of older adults and their family members about a fall risk assessment system. Using a qualitative approach, this study examined the perceptions, attitudes, and preferences of 13 older adults and five family members about their experience living with the fall risk assessment system during five points in time. Themes emerged in relation to preferences and expectations about the technology and how it fits into daily routines. We were able to capture changes that occurred over time for older adult participants. Results indicated that there was acceptance of the technology as participants adapted to it. Two themes were present across the five points in time-safety and usefulness. Five stages of acceptance emerged from the data from preinstallation to 2 years postinstallation. Identified themes, stages of acceptance, and design and development considerations are discussed.

  2. NASA wide electronic publishing system: Electronic printing and duplicating. Stage 3 evaluation report

    Science.gov (United States)

    Tuey, Richard C.; Moore, Fred W.; Ryan, Christine A.

    1995-01-01

    The report is presented in four sections: The Introduction describes the duplicating configuration under evaluation and the Background contains a chronological description of the evaluation segmented by phases 1 and 2. This section includes the evaluation schedule, printing and duplicating requirements, storage and communication requirements, electronic publishing system configuration, existing processes and proposed processes, billing rates, costs and productivity analysis, and the return on investment based upon the data gathered to date. The third section contains the phase 1 comparative cost and productivity analysis. This analysis demonstrated that LaRC should proceed with a 90-day evaluation of the DocuTech and follow with a phase 2 cycle to actually demonstrate that the proposed system would meet the needs of LaRC's printing and duplicating requirements, benchmark results, cost comparisons, benchmark observations, and recommendations. These are documented after the recommendations.

  3. Towards the Development of an M-Learning System: A New Stage to Enhance Higher Education

    Directory of Open Access Journals (Sweden)

    Samir Abou El-Seoud

    2009-07-01

    Full Text Available With the availability of high bandwidth wireless channels such as 3G-telecommunication infrastructure and wireless LAN, mobile learning (M-learning is becoming more feasible now. M-learning can be considered as an intersection of online learning and mobile computing. Through wireless devices (such as mobile telephones, Personal Digital Assistants - PDAs, tablet PC, and laptops and wireless applications, M-learning supports an integrated access to Web content and services in education anytime and anywhere. This paper describes the analysis, design, architecture, and experimental development of "Wireless Course Management System (WCMS", that provides a wireless access to course information content. The system allows the use of the wireless Web as a medium to administer, and deliver course content, to support wireless course management, tests and student wireless communications.

  4. A Clinical Evaluation of Three Force Delivery Systems in Stage II of the Begg Technique

    OpenAIRE

    Vincy Antony Margaret; Prathapan Parayaruthottam; K Jyothindra Kumar

    2013-01-01

    Introduction: Orthodontic treatment is presently dominated by two techniques, the Begg light wire differential force technique and the preadjusted edgewise technique. Orthodontic appliances at present commonly utilize sliding mechanics for extraction space closure with different types of force delivery systems. Materials and methods: The present study was designed to compare the rates of retraction and anchorage loss between elastics, elastomeric chains and nickel-titanium (NiTi) closed co...

  5. The role of renin angiotensin system intervention in stage B heart failure.

    LENUS (Irish Health Repository)

    Collier, Patrick

    2012-04-01

    This article outlines the link between the renin angiotensin aldosterone system (RAAS) and various forms of cardiomyopathy, and also reviews the understanding of the effectiveness of RAAS intervention in this phase of ventricular dysfunction. The authors focus their discussion predominantly on patients who have had previous myocardial infarction or those who have left ventricular hypertrophy and also briefly discuss the role of RAAS activation and intervention in patients with alcoholic cardiomyopathy.

  6. Vitamin effects on the immune system: vitamins A and D take centre stage

    OpenAIRE

    Mora, J. Rodrigo; Iwata, Makoto; von Andrian, Ulrich H.

    2008-01-01

    Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-spec...

  7. Functional Differentiation and Sustainability: A New Stage of Development in the Chinese Container Port System

    Directory of Open Access Journals (Sweden)

    Liehui Wang

    2017-02-01

    Full Text Available Adjacent ports played a significant role in the evolution of the port system. In our study, we selected five pairs (i.e., Dalian–Yingkou, Qingdao–Yantai, Shanghai–Ningbo, Xiamen–Quanzhou, and Shenzhen–Guangzhou of the most important adjacent ports in China to reveal the recent trend of China unique port system development; how and why will port system development be de-concentrated; and integrate the conceptual modal into in-depth analysis. The major findings are as follows: (1 There is functional differentiation in adjacent ports. To some big ports’ sustainability, they focus on foreign trade while other small ports, in order to achieve sustainable development, they focus on domestic trade; (2 First-mover advantage and dislocation competition is a mechanism of China ports functional differentiation; (3 Shanghai and Ningbo are unique in that both ports are similarly focused on foreign trade because they both have deep-water harbors, excellent geographical location, export-oriented hinterland economy, and close foreign investment relationships.

  8. The control system of the ecological hybrid two stages refrigerating cycle

    Directory of Open Access Journals (Sweden)

    Cyklis Piotr

    2016-01-01

    Full Text Available The compression anticlockwise cycle is mostly used for refrigeration. However due to the environmental regulations, the use of classic refrigerants: F-gases is limited by international agreements. Therefore the combined compression-adsorption hybrid cycle with natural liquids: water/carbon dioxide working as the energy carriers is a promising solution. This allows to utilize the solar or waste energy for the refrigeration purpose. In this paper application of the solar collectors as the energy source for the adsorption cycle, coupled with the low temperature (LT refrigerating carbon dioxide compression cycle is shown. The control of the system is an essential issue to reduce the electric power consumption. The control of the solar heat supply and water sprayed cooling tower, for the adsorption cycle re-cooling, is presented in this paper. The designed control system and algorithm is related to the LT compression cycle, which operates according to the need of cold for the refrigeration chamber. The results of the laboratory investigations of the full system, showing the reduction of the energy consumption and maximum utilization of the solar heat for different control methods are presented.

  9. Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

    Science.gov (United States)

    Lannes, Nils; Eppler, Elisabeth; Etemad, Samar; Yotovski, Peter; Filgueira, Luis

    2017-01-01

    Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the pathogenesis of neurodegenerative diseases and contribute to aging. They play an important role in sustaining and breaking the blood-brain barrier. As innate immune cells, they contribute substantially to the immune response against infectious agents affecting the CNS. They play also a major role in the growth of tumours of the CNS. Microglia are consequently the key cell population linking the nervous and the immune system. This review covers all different aspects of microglia biology and pathology in a comprehensive way. PMID:29371994

  10. Caries status in young Colombian children expressed by the ICCMS™ visual/radiographic combined caries staging system

    DEFF Research Database (Denmark)

    Cortes, Andrea; Ekstrand, Kim Rud; Gamboa, Luis Fernando

    2017-01-01

    OBJECTIVE: To report (1) the caries experience prevalence and mean, and the caries severity and distribution patterns, expressed clinically and combined with radiographs with the conventional and ICCMS™ systems in young children from Bogotá, Colombia; (2) the contribution of including radiographs...... to the clinical caries scoring and (3) in which surfaces the radiograph adds to the clinical caries registration. MATERIAL AND METHODS: Six hundred children from kindergartens/schools were enrolled: Cohort A: 2-year (n = 200), Cohort B: 4-year (n = 200) and Cohort C: 6-year (n = 200) olds. Radiographs were taken...... of the 4- and 6- year olds. Children were examined clinically using the Clinical (C) and Radiographic (R) ICCMS™-epi Caries Scoring Systems, staging caries lesions (d) as: Initial (Cepi/RA), Moderate (CM/RB) or Extensive (CE/RC). Caries experience including missing (m) and filled (f) surfaces was expressed...

  11. The tumor-stromal ratio as a strong prognosticator for advanced gastric cancer patients: proposal of a new TSNM staging system.

    Science.gov (United States)

    Peng, Chunwei; Liu, Jiuyang; Yang, Guifang; Li, Yan

    2017-08-16

    Insufficient attention is paid to the underlying tumor microenvironment (TME) evolution, that resulting in tumor heterogeneity and driving differences in cancer aggressiveness and treatment outcomes. The morphological evaluation of the proportion of the stroma at the most invasive part of primary tumor (tumor-stromal ratio, TSR) in cancer is gaining momentum as evidence strengthens for the clinical relevance. Tissue samples from the most invasive part of the primary gastric cancer (GC) of 494 patients were analyzed for their TSR, and a new TSNM (tumor-stromal node metastasis) staging system based on patho-biological behaviors was established and assessed. TSR is a new and strong independent prognostic factor for GC patients. The likelihood of tumor invasion is increased significantly for patients in the stromal-high subgroup compared to those in the stromal-low subgroup (P = 0.011). The discrimination ability of TSR was not less than the TNM staging system and was better in patients with stages I and II GC. We integrated the TSR parameter into the TNM staging system and proposed a new TSNM staging system creatively. There were three new subgroups (IC, IIC, IIID). There were four major groups and 10 subgroups in the TSNM system. The difference in overall survival (OS) was statistically significant among all TSNM system (P system has been established to optimize risk stratification for GC. The value of the TSNM staging system should be validated in further prospective study.

  12. Stage design

    International Nuclear Information System (INIS)

    Shacter, J.

    1975-01-01

    A method is described of cycling gases through a plurality of diffusion stages comprising the steps of admitting the diffused gases from a first diffusion stage into an axial compressor, simultaneously admitting the undiffused gases from a second diffusion stage into an intermediate pressure zone of said compressor corresponding in pressure to the pressure of said undiffused gases, and then admitting the resulting compressed mixture of diffused and undiffused gases into a third diffusion stage

  13. A Clinical Evaluation of Three Force Delivery Systems in Stage II of the Begg Technique

    Directory of Open Access Journals (Sweden)

    Vincy Antony Margaret

    2013-01-01

    Materials and methods: The present study was designed to compare the rates of retraction and anchorage loss between elastics, elastomeric chains and nickel-titanium (NiTi closed coil springs, using a continuous archwire system with the Begg light wire differential force technique. Results: The rate of canine retraction was faster by 0.6 mm per month with the NiTi closed coil spring compared to elastics and elastomeric chains. The NiTi closed coil springs produced more rapid rate of canine retraction but they also produced the greatest amount of anchorage loss.

  14. A Sensorless Power Reserve Control Strategy for Two-Stage Grid-Connected PV Systems

    DEFF Research Database (Denmark)

    Sangwongwanich, Ariya; Yang, Yongheng; Blaabjerg, Frede

    2017-01-01

    Due to the still increasing penetration of grid-connected Photovoltaic (PV) systems, advanced active power control functionalities have been introduced in grid regulations. A power reserve control, where namely the active power from the PV panels is reserved during operation, is required for grid...... to achieve the power reserve. In this method, the solar irradiance and temperature measurements that have been used in conventional power reserve control schemes to estimate the available PV power are not required, and thereby being a sensorless approach with reduced cost. Experimental tests have been...

  15. A Palaeoproterozoic multi-stage hydrothermal alteration system at Nalunaq gold deposit, South Greenland

    DEFF Research Database (Denmark)

    Bell, Robin-Marie; Kolb, Jochen; Waight, Tod Earle

    2017-01-01

    Nalunaq is an orogenic, high gold grade deposit situated on the Nanortalik Peninsula, South Greenland. Mineralisation is hosted in shear zone-controlled quartz veins, located in fine- and medium-grained amphibolite. The deposit was the site of Greenland’s only operating metalliferous mine until its...... closure in 2014, having produced 10.67 t of gold. This study uses a combination of field investigation, petrography and U/Pb zircon and titanite geochronology to define a multistage hydrothermal alteration system at Nalunaq. A clinopyroxene-plagioclase-garnet(-sulphide) alteration zone (CPGZ) developed...

  16. On the Performance of One Stage Massive Random Access Protocols in 5G Systems

    DEFF Research Database (Denmark)

    Mahmood, Nurul Huda; Pratas, Nuno; Jacobsen, Thomas

    2016-01-01

    The next generation of cellular system is expected to experience a proliferation in the number of emerging use cases alongside supporting high speed mobile broadband services. Massive Machine Type Communication (mMTC) catering to a large number of low-data rate, low-cost devices is such an emerging...... use case. Smart utility meters, automated sensors in farms, and vehicle tracking nodes for logistics monitoring are all examples of emerging mMTC devices. Ensuring efficient mechanisms to access the wireless channel for such a massive number of densely deployed devices is a key challenge posed by m...

  17. Potential risk factors in systemic hypoplasia and dental caries at odontogenesis stage

    Directory of Open Access Journals (Sweden)

    Kovach I.V.

    2013-03-01

    Full Text Available Lesion of hard dental tissue with caries process and lesions not connected with caries present overwhelming majority of dental diseases. Causes leading to damage of enamel integrity and dentin with progressing demineralization are known; they allow to choose justified method of primary prophylaxis. Along with it, etiology and pathogenesis of enamel lesions with demineralization signs remains unexplored. Epidemiologic study of prevalence, incidence and severity of lesion of hard dental tissues in 330 pupils, who constantly live on endemic iodine-defficient territory, of three zones – mountain zone, foothill and valley. For comparison, schoolchildren migrated to this territory 2-3 years after birth, and children – residents of favorable as for iodine level in drinking water were examined, 30 children in each group. It was established, that overwhelming number of schoolchildren of endemic zone suffer from endemic goiter of various severity, which sufficiently impacts on protein-mineral ratio of the organism, bone skeleton and teeth including. It was also established, that residents of three various levels of iodine consumption are prone to development of multiple dental caries and systemic enamel hypoplasia. Children, residents of mountain zone suffer the most, with simultaneous lesion of thyroid gland. The role of endemic goiter in systemic dental enamel hypoplasia and multiple caries, which changes protein matrix, negatively impacts on odontogenesis and mineralization degree is underlined.

  18. Influence of Electric, Magnetic, and Electromagnetic Fields on the Circadian System: Current Stage of Knowledge

    Science.gov (United States)

    Żak, Arkadiusz

    2014-01-01

    One of the side effects of each electrical device work is the electromagnetic field generated near its workplace. All organisms, including humans, are exposed daily to the influence of different types of this field, characterized by various physical parameters. Therefore, it is important to accurately determine the effects of an electromagnetic field on the physiological and pathological processes occurring in cells, tissues, and organs. Numerous epidemiological and experimental data suggest that the extremely low frequency magnetic field generated by electrical transmission lines and electrically powered devices and the high frequencies electromagnetic radiation emitted by electronic devices have a potentially negative impact on the circadian system. On the other hand, several studies have found no influence of these fields on chronobiological parameters. According to the current state of knowledge, some previously proposed hypotheses, including one concerning the key role of melatonin secretion disruption in pathogenesis of electromagnetic field induced diseases, need to be revised. This paper reviews the data on the effect of electric, magnetic, and electromagnetic fields on melatonin and cortisol rhythms—two major markers of the circadian system as well as on sleep. It also provides the basic information about the nature, classification, parameters, and sources of these fields. PMID:25136557

  19. Influence of electric, magnetic, and electromagnetic fields on the circadian system: current stage of knowledge.

    Science.gov (United States)

    Lewczuk, Bogdan; Redlarski, Grzegorz; Zak, Arkadiusz; Ziółkowska, Natalia; Przybylska-Gornowicz, Barbara; Krawczuk, Marek

    2014-01-01

    One of the side effects of each electrical device work is the electromagnetic field generated near its workplace. All organisms, including humans, are exposed daily to the influence of different types of this field, characterized by various physical parameters. Therefore, it is important to accurately determine the effects of an electromagnetic field on the physiological and pathological processes occurring in cells, tissues, and organs. Numerous epidemiological and experimental data suggest that the extremely low frequency magnetic field generated by electrical transmission lines and electrically powered devices and the high frequencies electromagnetic radiation emitted by electronic devices have a potentially negative impact on the circadian system. On the other hand, several studies have found no influence of these fields on chronobiological parameters. According to the current state of knowledge, some previously proposed hypotheses, including one concerning the key role of melatonin secretion disruption in pathogenesis of electromagnetic field induced diseases, need to be revised. This paper reviews the data on the effect of electric, magnetic, and electromagnetic fields on melatonin and cortisol rhythms-two major markers of the circadian system as well as on sleep. It also provides the basic information about the nature, classification, parameters, and sources of these fields.

  20. Influence of Electric, Magnetic, and Electromagnetic Fields on the Circadian System: Current Stage of Knowledge

    Directory of Open Access Journals (Sweden)

    Bogdan Lewczuk

    2014-01-01

    Full Text Available One of the side effects of each electrical device work is the electromagnetic field generated near its workplace. All organisms, including humans, are exposed daily to the influence of different types of this field, characterized by various physical parameters. Therefore, it is important to accurately determine the effects of an electromagnetic field on the physiological and pathological processes occurring in cells, tissues, and organs. Numerous epidemiological and experimental data suggest that the extremely low frequency magnetic field generated by electrical transmission lines and electrically powered devices and the high frequencies electromagnetic radiation emitted by electronic devices have a potentially negative impact on the circadian system. On the other hand, several studies have found no influence of these fields on chronobiological parameters. According to the current state of knowledge, some previously proposed hypotheses, including one concerning the key role of melatonin secretion disruption in pathogenesis of electromagnetic field induced diseases, need to be revised. This paper reviews the data on the effect of electric, magnetic, and electromagnetic fields on melatonin and cortisol rhythms—two major markers of the circadian system as well as on sleep. It also provides the basic information about the nature, classification, parameters, and sources of these fields.

  1. Mixture design approach for early stage formulation development of a transdermal delivery system.

    Science.gov (United States)

    Michaelis, M; Leopold, C S

    2015-01-01

    Transdermal delivery systems (TDS) consisting of mixtures of adhesives also named multiple polymer adhesive systems are rarely found in the market and research has only been performed on a few of them. Following the principles of ICH Q8, a Design of Experiments (DOE) approach was selected for the formulation development. For evaluation of the statistical method of "mixture design", blends of silicon adhesive, acrylic adhesive, oleyl alcohol as a surfactant and ibuprofen as a model drug were considered to be combined at different concentrations. A randomized design of 16 runs with five replicates and five runs to estimate the lack of fit (LOF) was generated. Samples were tested for adhesion properties, stability of the wet mixes, solubility of the API in the matrix and appearance of the matrix. After performing an ANOVA with the results, response surfaces of tack, shear adhesion, extent of creaming, crystallization behavior, droplet size and droplet size range were derived as contour plots. It could be shown that crystal growth of ibuprofen correlates well with droplet size and droplet size range, where lowest values for crystallization were found with mixtures containing small droplets. However, it was observed that oleyl alcohol showed no positive effect on the miscibility of the polymers and no improvement of the solubility of ibuprofen in the mixtures. With a reasonable number of experiments, the development of a design space for a TDS via mixture design gave valuable information on the product as well as on the interactions of the components.

  2. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines.

    Science.gov (United States)

    Zhang, Shiqian; Zhou, Xiaoliang; Yu, Hao; Yu, Yunhai

    2010-04-27

    To observe mRNA expression of tumor-specific antigen MAGE, BAGE and GAGE in epithelial ovarian cancer tissues and cell lines, to explore the relationship between gene expression and diagnosis, treatment and prognosis of ovarian cancer, and to evaluate the feasibility of their gene products as markers, and an immunotherapy target for ovarian cancer. mRNA expression of MAGE-1, MAGE-3, GAGE-1/2 and BAGE were determined by reverse transcription polymerase chain reaction (RT-PCR) in 14 cases of normal ovarian tissue, 20 cases of ovarian benign tumor specimens, 41 cases of ovarian cancer specimens, and ovarian cancer cell lines SKOV3, A2780, and COC1. MAGE, GAGE and BAGE genes were not expressed in normal ovarian tissue. In benign tumors, only the MAGE gene was expressed; the expression rate of this gene in benign tumors was 15% (3/20). In ovarian cancer tissues, MAGE-1 and MAGE-3 was highly expressed, with expression rates of 53.7% (22/41) and 36.6% (15/41), while GAGE-1/2 and BAGE had relatively low expression, with rates of 26.8% (11/41) and 14.6% (6/41). In metastatic lesions of ovarian cancer, only MAGE-1 and BAGE were expressed, with expression rates of 28.6% (2/7) and 14.3% (1/7). The positive expression rates of MAGE-1 and MAGE-3 in serous cystadenocarcinoma were significantly higher than that in other types of ovarian cancer (P BAGE was significantly higher in ovarian cancer patients with ascites (P BAGE in ovarian carcinoma cell lines SKOV3, A2780 and COC1 varied, but there was at least one gene expressed in each cell line. Tumor-specific antigen MAGE, BAGE and GAGE may play a role in the occurrence and development of ovarian cancer. These genes can be used as one of the important indicators for early diagnosis, efficacy evaluation and prognostic determination of ovarian cancer.

  3. Grid-connected integrated community energy system. Phase II, Stage 1, final report. Conceptual design: pyrolysis and waste management systems

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-08

    The University of Minnesota is studying and planning a grid-connected integrated community energy system to include disposal of wastes from health centers and utilizing the heat generated. Following initial definition of the 7-county metropolitan region for which the solid waste management system is to be planned, information is then necessary about the nature of the waste generated within this region. Estimates of the quantities generated, generation rates, and properties of the waste to be collected and disposed of are required in order to determine the appropriate size and capacity of the system. These estimates are designated and subsequently referred to as ''system input''. Institutional information is also necessary in designing the planned system, to be compatible with existing institutional operations and procedures, or to offer a minimum amount of problems to the participating institution in the region. Initial considerations of health care institutions generating solid waste within the defined region are made on a comprehensive basis without any attempt to select out or include feasible candidate institutions, or institutional categories. As the study progresses, various criteria are used in selecting potential candidate institutional categories and institutions within the 7-county region as offering the most feasible solid waste system input to be successfully developed into a centralized program; however, it is hoped that such a system if developed could be maintained for the entire 7-county region, and remain comprehensive to the entire health care industry. (MCW)

  4. Comparison of prognostic prediction between nomogram based on lymph node ratio and AJCC 8th staging system for patients with resected pancreatic head carcinoma: a SEER analysis

    Directory of Open Access Journals (Sweden)

    Pu N

    2018-02-01

    Full Text Available Ning Pu,1,2 Jianang Li,1,2 Yaolin Xu,1,2 Wanling Lee,1,2 Yuan Fang,1,2 Xu Han,1,2 Guochao Zhao,1,2 Lei Zhang,1,2 Abulimiti Nuerxiati,1,2 Hanlin Yin,1,2 Wenchuan Wu,1,2 Wenhui Lou1,2 1Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of Clinical Medicine, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Background: The prognosis of pancreatic carcinoma (PC remains poor and the American Joint Committee on Cancer (AJCC 8th staging system for survival prediction in PC patients after curative resection is still limited. Thus, the aim of this study is to refine a valuable prognostic model and novel staging system for PC with curative resection.Methods: The data of 3,458 patients used in this study were retrieved from the Surveillance, Epidemiology, and End Results database registry of National Cancer Institute. The prognostic value of lymph node ratio (LNR was analyzed in the primary cohort and prognostic nomogram based on the LNR was established to create a novel staging system. Then, analyses were conducted to evaluate the application of the formulated nomogram staging system and the AJCC 8th staging system. The predictive performance of model was further validated in the internal validation cohort.Results: Significant positive correlations were found between LNR and all factors except for surgical procedures. The results of univariate and multivariate analyses showed that LNR was identified as an independent prognostic indicator for overall survival (OS in both primary and validation cohorts (all P < 0.001. A prognostic nomogram based on the LNR was formulated to obtain superior discriminatory abilities. Compared with the AJCC 8th staging system, the formulated nomogram staging system showed higher hazard ratios of stage II, III, and IV disease (reference to stage I disease that were 1.637, 2.300, and 3.521, respectively, by univariate analyses

  5. The cross talk between microbiota and the immune system: metabolites take center stage.

    Science.gov (United States)

    Shapiro, Hagit; Thaiss, Christoph A; Levy, Maayan; Elinav, Eran

    2014-10-01

    The human meta-organism consists of more than 90% of microbial cells. The gastrointestinal tract harbors trillions of commensal microorganisms that influence the development and homeostasis of the host. Alterations in composition and function of the microbiota, termed dysbiosis, have been implicated in a multitude of metabolic and inflammatory diseases in humans. Thus, understanding the molecular underpinnings the cross talk between commensal bacteria and their host during homeostasis and dysbiosis may hold the key to understanding many idiopathic diseases. While most attention has focused on the innate recognition of immune-stimulatory bacterial molecules, such as cell wall components and nucleic acids, we emphasize here the impact of diet-dependent microbial metabolites on the development and function of the immune system. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Vitamin effects on the immune system: vitamins A and D take centre stage.

    Science.gov (United States)

    Mora, J Rodrigo; Iwata, Makoto; von Andrian, Ulrich H

    2008-09-01

    Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity.

  7. Grid-connected integrated community energy system. Phase II, Stage 2, final report. Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-22

    The University of Minnesota Grid-ICES was divided into four identifiable programs in order to study the feasibility of each of the parts of the ICES independently. The total program involves cogeneration, fuel conversion, fuel substitution, and energy conservation by system change. This Phase II report substantiates the theory that the Basic Grid ICES is not only energy-effective, but it will become cost effective as unit operating costs adjust to supply and demand in the 1980's. The Basic Program involves the cogeneration of steam and electricity. The University of Minnesota has been following an orderly process of converting its Central Heating Plant from gas-oil to 100% coal since 1973. The first step in the transition is complete. The University is presently 100% on coal, and will begin the second step, the test burning of low Btu Western coal during the spring, summer, and fall, and high Btu Eastern coal during the high thermal winter period. The final step to 100% Western coal is planned to be completed by 1980. In conjunction with the final step a retired Northern States Power generating plant has been purchased and is in the process of being retrofitted for topping the existing plant steam output during the winter months. The Basic Plan of ICES involves the add-on work and expense of installing additional boiler capacity at Southeast Steam and non-condensing electric generating capability. This will permit the simultaneous generation of electricity and heat dependent upon the thermal requirements of the heating and cooling system in University buildings. This volume presents an overview of the Community and the ICES. (MCW)

  8. The Future of the Plate Boundary Observatory in the GAGE Facility and beyond 2018

    Science.gov (United States)

    Mattioli, G. S.; Bendick, R. O.; Foster, J. H.; Freymueller, J. T.; La Femina, P. C.; Miller, M. M.; Rowan, L.

    2014-12-01

    The Geodesy Advancing Geosciences and Earthscope (GAGE) Facility, which operates the Plate Boundary Observatory (PBO), builds on UNAVCO's strong record of facilitating research and education in the geosciences and geodesy-related engineering fields. Precise positions and velocities for the PBO's ~1100 continuous GPS stations and other PBO data products are used to address a wide range of scientific and technical issues across North America. A large US and international community of scientists, surveyors, and civil engineers access PBO data streams, software, and other on-line resources daily. In a global society that is increasingly technology-dependent, consistently risk-averse, and often natural resource-limited, communities require geodetic research, education, and infrastructure to make informed decisions about living on a dynamic planet. The western U.S. and Alaska, where over 95% of the PBO sensor assets are located, have recorded significant geophysical events like earthquakes, volcanic eruptions, and tsunami. UNAVCO community science provides first-order constraints on geophysical processes to support hazards mapping and zoning, and form the basis for earthquake and tsunami early warning applications currently under development. The future of PBO was discussed at a NSF-sponsored three-day workshop held in September 2014 in Breckenridge, CO. Over 40 invited participants and community members, including representatives from interested stakeholder groups, UNAVCO staff, and members of the PBO Working Group and Geodetic Infrastructure Advisory Committee participated in workshop, which included retrospective and prospective plenary presentations and breakout sessions focusing on specific scientific themes. We will present some of the findings of that workshop in order to continue a dialogue about policies and resources for long-term earth observing networks. How PBO fits into the recently released U.S. National Plan for Civil Earth Observations will also be

  9. Internships and UNAVCO: Training the Future Geoscience Workforce Through the NSF GAGE Facility

    Science.gov (United States)

    Morris, A. R.; MacPherson-Krutsky, C. C.; Charlevoix, D. J.; Bartel, B. A.

    2015-12-01

    Facilities are uniquely positioned to both serve a broad, national audience and provide unique workforce experience to students and recent graduates. Intentional efforts dedicated to broadening participation in the future geoscience workforce at the NSF GAGE (Geodesy Advancing Geosciences and EarthScope) Facility operated by UNAVCO, are designed to meet the needs of the next generation of students and professionals. As a university-governed consortium facilitating research and education in the geosciences, UNAVCO is well-situated to both prepare students for geoscience technical careers and advanced research positions. Since 1998, UNAVCO has offered over 165 student assistant or intern positions including engineering, data services, education and outreach, and business support. UNAVCO offers three formal programs: the UNAVCO Student Internship Program (USIP), Research Experiences in Solid Earth Science for Students (RESESS), and the Geo-Launchpad (GLP) internship program. Interns range from community college students up through graduate students and recent Masters graduates. USIP interns gain real-world work experience in a professional setting, collaborate with teams toward a common mission, and contribute their knowledge, skills, and abilities to the UNAVCO community. RESESS interns conduct authentic research with a scientist in the Front Range area as well as participate in a structured professional development series. GLP students are in their first 2 years of higher education and work alongside UNAVCO technical staff gaining valuable work experience and insight into the logistics of supporting scientific research. UNAVCO's efforts in preparing the next generation of scientists largely focuses on increasing diversity in the geosciences, whether continuing academic studies or moving into the workforce. To date, well over half of our interns and student assistants come from backgrounds historically underrepresented in the geosciences. Over 80% of former interns

  10. Staging of cutaneous melanoma

    NARCIS (Netherlands)

    P. Mohr (P.); A.M.M. Eggermont (Alexander); A. Hauschild (Axel); A. Buzaid (A.)

    2009-01-01

    textabstractThe American Joint Committee on Cancer (AJCC) staging of cutaneous melanoma is a continuously evolving system. The identification of increasingly more accurate prognostic factors has led to major changes in melanoma staging over the years, and the current system described in this review

  11. The Second Stage Development of the Californium -252 SEU Testing System

    Science.gov (United States)

    Chen, Runhong

    This research has made improvements and added features to the Cf-252 single event upset (SEU) testing system. With the improved system, data acquisition speed has increased from 0.1 Hz to 10 Hz. High quality thin film scintillators and attenuators have been produced. The scintillators have efficiency for fission fragment detection about 95-98% and thickness from 1.5 to 2 mu m. Software for data acquisition, analysis and processing has been developed. All programs run under Microsoft Windows environment. Two types of SEU tests for a 2k times 8 SRAM (static random access memory) have been conducted. The first type of tests is with 12 attenuator at 0 angle. The SEU cross section curves for two-group divisions of fission fragments confirms the results obtained with accelerator. The second type is conducted at a series of DUT (device under test) angle from 0^ circ to 70^circ with six attenuator. Test results show the curves of SEU cross section versus angle generally have small rising as angle increases, and at higher angle the curves fall rapidly. A technique for dividing the Cf-252 energy spectrum into six groups has been developed for further studying the relations between SEU and fission fragment species. Compared with the two-group results, the results of the six-group divisions show more details of the device's SEU characteristics. A three-layer 1-D model is proposed to explain the pattern observed in the tests with different DUT angles. In this model, the memory device is considered as consisting of a SiO_2 passive layer on the device surface, an SEU sensitive region and the substrate made of Si. The passive layer and the substrate are not SEU sensitive. The validity of the concept of effective linear energy transfer is examined in detail. The energy deposited in the sensitive region is proposed as another SEU parameter. It can explain the observed pattern satisfactorily. Assuming SEU is proportional to the deposited energy, the thickness of the two layers can be

  12. Intraoperative localization of colorectal tumors in the early stages using a marking clip detector system.

    Science.gov (United States)

    Ohdaira, T; Konishi, F; Nagai, H; Kashiwagi, H; Shito, K; Togashi, K; Kanazawa, K

    1999-10-01

    In laparoscopic colectomy the identification of the site of a tumor is often difficult. The topical injection of india ink or blue dye by preoperative colonoscopy is the most prevalent method to mark the tumor site; however, such a procedure also includes the intrinsic danger of possibly injecting dye into the peritoneal cavity. In addition, the injected marker may also spread so widely that the intended site may become obscure. A marking clip detector system was used to detect metallic marking clips in the luminal side that had been applied to the mucosa adjacent to the lesion during the course of preoperative colonoscopy. This method was able to identify the marked site in 40 percent of cases in which only one clip was applied to the mucosa. However, when the lesion sites were marked with two or three clips, then the detection rate increased to 100 percent. Based on our findings, this procedure was found to be a safe and reliable method for identifying lesions during laparoscopic-assisted colectomy.

  13. Neck keloids: evaluation of risk factors and recommendation for keloid staging system [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Michael H. Tirgan

    2016-08-01

    Full Text Available Importance: Health care providers have long struggled with recurrent and hard to treat keloids. Advancing our understanding of natural history and risk factors for development of large, very large and massive neck keloids can lead to improved treatment outcomes. Clinical staging system for the categorization of keloid lesions, as well as grouping of keloid patients according to the extent of skin involvement is both fundamental for design and delivery of proper plan of care and an absolute necessity for methodical trial design and interpretation of the results thereof. Objective: To review clinical presentation and natural history of neck keloids; to explore risk factors for development of large, very large and massive neck keloids; and to propose a clinical staging system that allows for categorization of keloid lesions by their size and grouping of keloid patients by the extent of their skin involvement.  Setting: This is a retrospective analysis of 82 consecutive patients with neck keloids who were seen by the author in his keloid specialty medical practice.    Intervention: Non-surgical treatment was offered to all patients.  Results: Neck-area keloids were found to have several unique characteristics. All 65 African Americans in this study had keloidal lesions elsewhere on their skin. Very large and massive neck keloids appear to be race-specific and almost exclusively seen among African Americans. Submandibular and submental skin was the most commonly involved area of the neck. Keloid removal surgery was found to be the main risk factor for development of very large and massive neck keloids.  Conclusions and relevance: Surgical removal of neck keloids results in wounding of the skin and triggering a pathological wound-healing response that often leads to formation of a much larger keloid.  Given the potential for greater harm from surgery, the author proposes non-surgical approach for treatment of all primary neck keloids. Author

  14. Cluster emission at pre-equilibrium stage in Heavy Nuclear Reactions. A Model considering the Thermodynamics of Small Systems

    International Nuclear Information System (INIS)

    Bermudez Martinez, A.; Damiani, D.; Guzman Martinez, F.; Rodriguez Hoyos, O.; Rodriguez Manso, A.

    2015-01-01

    Cluster emission at pre-equilibrium stage, in heavy ion fusion reactions of 12 C and 16 O nuclei with 116 Sn, 208 Pb, 238 U are studied. the energy of the projectile nuclei was chosen at 0.25GeV, 0.5GeV and 1GeV. A cluster formation model is developed in order to calculate the cluster size. Thermodynamics of small systems was used in order to examine the cluster behavior inside the nuclear media. This model is based on considering two phases inside the compound nucleus, on one hand the nuclear media phase, and on the other hand the cluster itself. The cluster acts like an instability inside the compound nucleus, provoking an exchange of nucleons with the nuclear media through its surface. The processes were simulated using Monte Carlo methods. We obtained that the cluster emission probability shows great dependence on the cluster size. This project is aimed to implement cluster emission processes, during the pre-equilibrium stage, in the frame of CRISP code (Collaboration Rio-Sao Paulo). (Author)

  15. Relations between the stimulation of mixed lymphocyte populations and the staging system according Rai in patients with chronic lymphatic leukemia

    International Nuclear Information System (INIS)

    Heilmann, E.; Venne, U.

    1979-01-01

    By means of the incorporation rate of 3 H thymidine into the lymphocytes of patients with chronic lymphatic leukemia the possibility of stimulating them by using different mitogens was checked and compared with normal persons. The examination covered 11 patients treated with extracorporeal irradiation of the blood (ECIB), 5 patients treated with a chlorambucil therapy, and 10 untreated patients who where classified according to the staging system proposed by Rai. The lymphocytes of the peripheral blood were stimulated as mixed and isolated T and B-lymphocytes in the microculture by using the mitogens PHA, PWM, ConA, and LPS. In all CLL patients there was a diminished stimulation rate of a mixed lymphocyte population. A relation existed between the seriousness of the stage and the deminution of the incorporation rate of 3 H thymidine. A corresponding correlation could not be identified in untreated CLL patients. Isolated T-lymphocytes revealed better results of stimulation than the total population. As to their function B-lymphocytes showed a dependence on the kind of therapy. In the mixed lymphocyte culture of normal persons the best findings could be observed after stimulation with PHA, that is also valid for CLL patients. PHA, PWA, ConA, and LPS were suitable as substances stimulating B-lymphocytes with different efficacy in normal persons and CLL patients. Both collectives showed the best results in the T-lymphocyte culture after stimulation with LPS. (author)

  16. Design and analysis of a 3-DOF planar micromanipulation stage with large rotational displacement for micromanipulation system

    Directory of Open Access Journals (Sweden)

    B. Ding

    2017-05-01

    Full Text Available Flexure-based mechanisms have been widely used for scanning tunneling microscopy, nanoimprint lithography, fast servo tool system and micro/nano manipulation. In this paper, a novel planar micromanipulation stage with large rotational displacement is proposed. The designed monolithic manipulator has three degrees of freedom (DOF, i.e. two translations along the X and Y axes and one rotation around Z axis. In order to get a large workspace, the lever mechanism is adopted to magnify the stroke of the piezoelectric actuators and also the leaf beam flexure is utilized due to its large rotational scope. Different from conventional pre-tightening mechanism, a modified pre-tightening mechanism, which is less harmful to the stacked actuators, is proposed in this paper. Taking the circular flexure hinges and leaf beam flexures hinges as revolute joints, the forward kinematics and inverse kinematics models of this stage are derived. The workspace of the micromanipulator is finally obtained, which is based on the derived kinematic models.

  17. Development of a compact, fiber-coupled, six degree-of-freedom measurement system for precision linear stage metrology

    International Nuclear Information System (INIS)

    Yu, Xiangzhi; Gillmer, Steven R.; Woody, Shane C.; Ellis, Jonathan D.

    2016-01-01

    A compact, fiber-coupled, six degree-of-freedom measurement system which enables fast, accurate calibration, and error mapping of precision linear stages is presented. The novel design has the advantages of simplicity, compactness, and relatively low cost. This proposed sensor can simultaneously measure displacement, two straightness errors, and changes in pitch, yaw, and roll using a single optical beam traveling between the measurement system and a small target. The optical configuration of the system and the working principle for all degrees-of-freedom are presented along with the influence and compensation of crosstalk motions in roll and straightness measurements. Several comparison experiments are conducted to investigate the feasibility and performance of the proposed system in each degree-of-freedom independently. Comparison experiments to a commercial interferometer demonstrate error standard deviations of 0.33 μm in straightness, 0.14 μrad in pitch, 0.44 μradin yaw, and 45.8 μrad in roll.

  18. Simulation and parameter analysis of a two-stage desiccant cooing/heating system driven by solar air collectors

    International Nuclear Information System (INIS)

    Li, H.; Dai, Y.J.; Köhler, M.; Wang, R.Z.

    2013-01-01

    Highlights: ► A solar desiccant cooling/heating system is simulation studied. ► The mean deviation is about 10.5% for temperature and 9.6% for humidity ratio. ► The 51.7% of humidity load and 76% of the total cooling can be handled. ► About 49.0% of heating load can be handled by solar energy. ► An optimization of solar air collector has been investigated. - Abstract: To increase the fraction of solar energy might be used in supplying energy for the operation of a building, a solar desiccant cooling and heating system was modeled in Simulink. First, base case performance models were programmed according to the configuration of the installed solar desiccant system and verified by the experimental data. Then, the year-round performance about the system was simulated. Last, design parameters of solar air collectors were optimized that include collector area, air leakage and thermal insulation. Comparison between numerical and experimental results shows good agreement. During the simulation, the humidity load for 63 days (51.7%) can be totally handled by the two-stage desiccant cooling unit. For seasonal total heating load, about 49.0% can be handled by solar energy. Based on optimized results, the thermal energy subsystem functioned to its expected performance in solar energy collection and thermal storage

  19. Common user considerations (CUC) by developing countries for future nuclear energy systems: Report of stage 1

    International Nuclear Information System (INIS)

    2009-01-01

    This publication collects and summarizes the opinions of experts from developing countries that are considering the deployment of nuclear power plants in the near term, or are making projections for the deployment of nuclear power plants in the next 40 years (up to 2050). It is intended to establish an early dialogue between these countries (called technology users or user countries here) and the countries that already possess nuclear technology capabilities (called technology holders here). It can also be used in conjunction with other IAEA publications to address institutional and infrastructure needs, to foster the development of additional nuclear energy systems, or as the basis for discussion or domestic planning of the step by step process for the deployment of a new nuclear power plant that in some cases may be the first. The publication also provides substantial background information collected by the IAEA regarding additional characteristics and expectations of these countries. The countries addressed in this publication were selected using the World Bank's definition of developing economies. The countries included have also given an indication of interest in developing or deploying new nuclear power plants. Countries that already have a significant ongoing nuclear programme (e.g. China and India) were excluded. This publication was prepared by the IAEA with inputs from about two hundred experts from the countries that participated in this activity. The process used to develop the publication involved multiple meetings between the IAEA and experts from 35 countries. Additional input from experts from some of the countries defined as the technology holders was also included at different steps of the process. The process was intended to develop a consensus and this publication represents an agreement among the experts from the many different countries and organizations represented at the different steps. The publication incorporated lessons learned from user

  20. Two-stage actuation system using DC motors and piezoelectric actuators for controllable industrial and automotive brakes and clutches

    Science.gov (United States)

    Neelakantan, Vijay A.; Washington, Gregory N.; Bucknor, Norman K.

    2005-05-01

    High bandwidth actuation systems that are capable of simultaneously producing relatively large forces and displacements are required for use in automobiles and other industrial applications. Conventional hydraulic actuation mechanisms used in automotive brakes and clutches are complex, inefficient and have poor control robustness. These lead to reduced fuel economy, controllability issues and other disadvantages. This paper involves the design, development, testing and control of a two-stage hybrid actuation mechanism by combining classical actuators like DC motors and advanced smart material actuators like piezoelectric actuators. The paper also discusses the development of a robust control methodology using the Internal Model Control (IMC) principle and emphasizes the robustness property of this control methodology by comparing and studying simulation and experimental results.

  1. MANTLE-CRUST INTERACTION AT THE LATE STAGE OF EVOLUTION OF HERCYNIAN ALTAI COLLISION SYSTEM, WESTERN PART OF CAOB

    Directory of Open Access Journals (Sweden)

    S. V. Khromykh

    2017-01-01

    Full Text Available Altai collision system of Hercynides was formed in Late Paleozoic as a result of oblique collision of Siberian continent and Kazakhstan composed terrane [Vladimirov et al., 2003; 2008; Xiao et al., 2010]. At the late stages of its evolution (time interval from 310–300 to 280–270 Ma the huge different mafic and felsic magmatism occurred at the territory (Fig. 1 [Vladimirov et al., 2008; Khromykh et al., 2011, 2013, 2014, 2016; Kotler et al., 2015; Sokolova et al., 2016]. It is evident about increased thermal gradient in lithosphere and about significant role of mantle and active manifestation of mantle-crust interactions. Some magmatic complexes may be considered as indicators of mantle-crust interaction processes.

  2. Commercial multicopter unmanned aircraft system as a tool for early stage forest survey after wind damage

    Science.gov (United States)

    Mokros, Martin; Vybostok, Jozef; Merganic, Jan; Tomastik, Julian; Cernava, Juraj

    2017-04-01

    In recent years unmanned aircraft systems (UAS) are objects of research in many areas. This trend can be seen also in forest research where researchers are focusing on height, diameter and tree crown measurements, monitoring of forest fire, forest gaps and health condition. Our research is focusing on the use of UAS for detecting areas disturbed by wind and deriving the volume of fallen trees for management purposes. This information is crucial after the wind damage happened. We used DJI Phantom 2 Vision+ and acquired the imagery of one forest stand (5.7 ha). The UAS is a quadcopter "all in one" solution. It has a built-in camera with gimbal and a remote controller. The camera is controlled through the application (android/ios). The built-in camera has an image resolution of 4384×3288 (14 megapixels). We have placed five crosses within the plot to be able to georeference the point cloud from UAS. Their positions were measured by Topcon Hiper GGD survey-grade GNSS receiver. We measured the border of damaged area by four different GNSS devices - GeoExplorer 6000, Trimble Nomad, Garmin GPSMAP 60 CSx and by smartphone Sony Xperia X. To process images from UAS we used Agisoft Photoscan Professional, while ArcGIS 10.2 was used to calculate and compare the areas . From the UAS point cloud we calculated DTM and DSM and deducted them. The areas where the difference was close to zero (-0.2 to 0.2) were signed as potentially wind damage areas. Then we filtered the areas that were not signed correctly (for example routes). The calculated area from UAS was 2.66 ha, GeoExplorer 6000 was 2.20 ha, Nomad was 2.06 ha, Garmin was 2.21 ha and from Xperia was the area 2.24 ha. The differences between UAS and GPS devices vary from 0.42 ha to 0.6 ha. The differences were mostly caused by inability to detect small spots of fallen trees on UAS data. These small spots are difficult to measure by GPS devices because the signal is very poor under tree crowns and also it is difficult to find

  3. Trading stages

    DEFF Research Database (Denmark)

    Steiner, Uli; Tuljapurkar, Shripad; Coulson, Tim

    2012-01-01

    because they are hard to use and interpret, and tools for age and stage structured populations are missing. We present easily interpretable expressions for the sensitivities and elasticities of life expectancy to vital rates in age-stage models, and illustrate their application with two biological......Interest in stage-and age structured models has recently increased because they can describe quantitative traits such as size that are left out of age-only demography. Available methods for the analysis of effects of vital rates on lifespan in stage-structured models have not been widely applied...... examples. Much of our approach relies on trading of time and mortality risk in one stage for time and risk in others. Our approach contributes to the new framework of the study of age- and stage-structured biodemography....

  4. NASAwide electronic publishing system-prototype STI electronic document distribution: Stage-4 evaluation report. Part 2; Appendices

    Science.gov (United States)

    Tuey, Richard C.; Collins, Mary; Caswell, Pamela; Haynes, Bob; Nelson, Michael L.; Holm, Jeanne; Buquo, Lynn; Tingle, Annette; Cooper, Bill; Stiltner, Roy

    1996-01-01

    This evaluation report contains an introduction, seven chapters, and five appendices. The Introduction describes the purpose, conceptual framework, functional description, and technical report server of the Scientific and Technical Information (STI) Electronic Document Distribution (EDD) project. Chapter 1 documents the results of the prototype STI EDD in actual operation. Chapter 2 documents each NASA center's post processing publication processes. Chapter 3 documents each center's STI software, hardware. and communications configurations. Chapter 7 documents STI EDD policy, practices, and procedures. The appendices consist of (A) the STI EDD Project Plan, (B) Team members, (C) Phasing Schedules, (D) Accessing On-line Reports, and (E) Creating an HTML File and Setting Up an xTRS. In summary, Stage 4 of the NASAwide Electronic Publishing System is the final phase of its implementation through the prototyping and gradual integration of each NASA center's electronic printing systems, desk top publishing systems, and technical report servers, to be able to provide to NASA's engineers, researchers, scientists, and external users, the widest practicable and appropriate dissemination of information concerning its activities and the result thereof to their work stations.

  5. Prognosis of patients with hepatocellular carcinoma. Validation and ranking of established staging-systems in a large western HCC-cohort.

    Directory of Open Access Journals (Sweden)

    Mark op den Winkel

    Full Text Available BACKGROUND: HCC is diagnosed in approximately half a million people per year, worldwide. Staging is a more complex issue than in most other cancer entities and, mainly due to unique geographic characteristics of the disease, no universally accepted staging system exists to date. Focusing on survival rates we analyzed demographic, etiological, clinical, laboratory and tumor characteristics of HCC-patients in our institution and applied the common staging systems. Furthermore we aimed at identifying the most suitable of the current staging systems for predicting survival. METHODOLOGY/PRINCIPAL FINDINGS: Overall, 405 patients with HCC were identified from an electronic medical record database. The following seven staging systems were applied and ranked according to their ability to predict survival by using the Akaike information criterion (AIC and the concordance-index (c-index: BCLC, CLIP, GETCH, JIS, Okuda, TNM and Child-Pugh. Separately, every single variable of each staging system was tested for prognostic meaning in uni- and multivariate analysis. Alcoholic cirrhosis (44.4% was the leading etiological factor followed by viral hepatitis C (18.8%. Median survival was 18.1 months (95%-CI: 15.2-22.2. Ascites, bilirubin, alkaline phosphatase, AFP, number of tumor nodes and the BCLC tumor extension remained independent prognostic factors in multivariate analysis. Overall, all of the tested staging systems showed a reasonable discriminatory ability. CLIP (closely followed by JIS was the top-ranked score in terms of prognostic capability with the best values of the AIC and c-index (AIC 2286, c-index 0.71, surpassing other established staging systems like BCLC (AIC 2343, c-index 0.66. The unidimensional scores TNM (AIC 2342, c-index 0.64 and Child-Pugh (AIC 2369, c-index 0.63 performed in an inferior fashion. CONCLUSIONS/SIGNIFICANCE: Compared with six other staging systems, the CLIP-score was identified as the most suitable staging system for

  6. The validation of a three-stage screening methodology for detecting active convulsive epilepsy in population-based studies in health and demographic surveillance systems

    Directory of Open Access Journals (Sweden)

    Ngugi Anthony K

    2012-11-01

    Full Text Available Abstract Background There are few studies on the epidemiology of epilepsy in large populations in Low and Middle Income Countries (LMIC. Most studies in these regions use two-stage population-based screening surveys, which are time-consuming and costly to implement in large populations required to generate accurate estimates. We examined the sensitivity and specificity of a three-stage cross-sectional screening methodology in detecting active convulsive epilepsy (ACE, which can be embedded within on-going census of demographic surveillance systems. We validated a three-stage cross-sectional screening methodology on a randomly selected sample of participants of a three-stage prevalence survey of epilepsy. Diagnosis of ACE by an experienced clinician was used as ‘gold standard’. We further compared the expenditure of this method with the standard two-stage methodology. Results We screened 4442 subjects in the validation and identified 35 cases of ACE. Of these, 18 were identified as false negatives, most of whom (15/18 were missed in the first stage and a few (3/18 in the second stage of the three-stage screening. Overall, this methodology had a sensitivity of 48.6% and a specificity of 100%. It was 37% cheaper than a two-stage survey. Conclusion This was the first study to evaluate the performance of a multi-stage screening methodology used to detect epilepsy in demographic surveillance sites. This method had poor sensitivity attributed mainly to stigma-related non-response in the first stage. This method needs to take into consideration the poor sensitivity and the savings in expenditure and time as well as validation in target populations. Our findings suggest the need for continued efforts to develop and improve case-ascertainment methods in population-based epidemiological studies of epilepsy in LMIC.

  7. The validation of a three-stage screening methodology for detecting active convulsive epilepsy in population-based studies in health and demographic surveillance systems.

    Science.gov (United States)

    Ngugi, Anthony K; Bottomley, Christian; Chengo, Eddie; Kombe, Martha Z; Kazungu, Michael; Bauni, Evasius; Mbuba, Caroline K; Kleinschmidt, Immo; Newton, Charles R

    2012-11-21

    There are few studies on the epidemiology of epilepsy in large populations in Low and Middle Income Countries (LMIC). Most studies in these regions use two-stage population-based screening surveys, which are time-consuming and costly to implement in large populations required to generate accurate estimates. We examined the sensitivity and specificity of a three-stage cross-sectional screening methodology in detecting active convulsive epilepsy (ACE), which can be embedded within on-going census of demographic surveillance systems.We validated a three-stage cross-sectional screening methodology on a randomly selected sample of participants of a three-stage prevalence survey of epilepsy. Diagnosis of ACE by an experienced clinician was used as 'gold standard'. We further compared the expenditure of this method with the standard two-stage methodology. We screened 4442 subjects in the validation and identified 35 cases of ACE. Of these, 18 were identified as false negatives, most of whom (15/18) were missed in the first stage and a few (3/18) in the second stage of the three-stage screening. Overall, this methodology had a sensitivity of 48.6% and a specificity of 100%. It was 37% cheaper than a two-stage survey. This was the first study to evaluate the performance of a multi-stage screening methodology used to detect epilepsy in demographic surveillance sites. This method had poor sensitivity attributed mainly to stigma-related non-response in the first stage. This method needs to take into consideration the poor sensitivity and the savings in expenditure and time as well as validation in target populations. Our findings suggest the need for continued efforts to develop and improve case-ascertainment methods in population-based epidemiological studies of epilepsy in LMIC.

  8. Usefulness of a disease severity staging classification system for IPF in Japan: 20 years of experience from empirical evidence to randomized control trial enrollment.

    Science.gov (United States)

    Homma, Sakae; Sugino, Keishi; Sakamoto, Susumu

    2015-01-01

    Since 1991, the severity of idiopathic pulmonary fibrosis (IPF) has been classified into 4 stages-stage I (characterized by a resting PaO2 ≥ 80 Torr), stage II (70-79 Torr), stage III (60-69 Torr), or stage IV (<60 Torr)-to aid decisions on medical care subsidization in Japan. Among patients with stage II/III IPF, the severity should be increased by one stage if the lowest oxygen saturation on pulse oximetry (SpO2) is <90% during a 6-min walk test. Patients with stage III/IV IPF receive Japanese government subsidies for incurable diseases. This classification system highly correlates with serial changes in the percentage of vital capacity (%VC), the diffusing capacity for carbon monoxide, the incidence of acute exacerbation, and survival. A phase III trial of pirfenidone showed that IPF patients with an SpO2 on exertion of <90% and either a %VC ≥ 70% or a PaO2 ≥ 70 Torr (which includes most patients with stage III disease) at baseline would benefit from pirfenidone treatment. Recent post-marketing surveillance of 1370 patients--67.3% of whom had stage III/IV IPF--showed that pirfenidone was well-tolerated among those treated for longer than 6 months (63% of patients). A Japanese randomized controlled trial (RCT) demonstrated that inhaled N-acetylcysteine monotherapy benefitted patients with early IPF (stage I/II, with no desaturation on exertion). Thus, N-acetylcysteine monotherapy is suitable for early IPF, and pirfenidone is indicated for advanced disease. The classification of IPF severity is important in identifying clinically responsive patients and those suitable for RCT enrollment. Copyright © 2014 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.

  9. A web-based Tamsui River flood early-warning system with correction of real-time water stage using monitoring data

    Science.gov (United States)

    Liao, H. Y.; Lin, Y. J.; Chang, H. K.; Shang, R. K.; Kuo, H. C.; Lai, J. S.; Tan, Y. C.

    2017-12-01

    Taiwan encounters heavy rainfalls frequently. There are three to four typhoons striking Taiwan every year. To provide lead time for reducing flood damage, this study attempt to build a flood early-warning system (FEWS) in Tanshui River using time series correction techniques. The predicted rainfall is used as the input for the rainfall-runoff model. Then, the discharges calculated by the rainfall-runoff model is converted to the 1-D river routing model. The 1-D river routing model will output the simulating water stages in 487 cross sections for the future 48-hr. The downstream water stage at the estuary in 1-D river routing model is provided by storm surge simulation. Next, the water stages of 487 cross sections are corrected by time series model such as autoregressive (AR) model using real-time water stage measurements to improve the predicted accuracy. The results of simulated water stages are displayed on a web-based platform. In addition, the models can be performed remotely by any users with web browsers through a user interface. The on-line video surveillance images, real-time monitoring water stages, and rainfalls can also be shown on this platform. If the simulated water stage exceeds the embankments of Tanshui River, the alerting lights of FEWS will be flashing on the screen. This platform runs periodically and automatically to generate the simulation graphic data of flood water stages for flood disaster prevention and decision making.

  10. Simplified HCC-ART score for highly sensitive detection of small-sized and early-stage hepatocellular carcinoma in the widely used Okuda, CLIP, and BCLC staging systems.

    Science.gov (United States)

    Attallah, Abdelfattah M; Omran, Mohamed M; Attallah, Ahmed A; Abdelrazek, Mohamed A; Farid, Khaled; El-Dosoky, Ibrahim

    2017-04-01

    Small-sized HCC can be effectively cured by surgery with good clinical outcomes. A highly sensitive HCC α-fetoprotein routine test (HCC-ART) for HCC diagnosis as well as a simplied form of the HCC-ART were reported in the British Journal of Cancer. Here, we verified and studied the applicability of the HCC-ART to the detection of early-stage HCC. 341 cirrhotic patients and 318 HCC patients were included in this study. For each, the HCC-ART score was calculated, and then the sensitivity, specificity, and results of an ROC curve analysis were compared between the HCC-ART and AFP when these biomarkers were used to detect small-sized HCC. Different HCC-ART cutoffs were set for the detection of different tumor sizes. The HCC-ART (AUC = 0.871, 70% sensitivity, 97% specificity) and the simplified HCC-ART (AUC = 0.934, 82% sensitivity, 100% specificity) were found to have high predictive power when attempting to separate cirrhotic patients from those with small-sized HCC. The simplified HCC-ART score was superior to AFP for determining stages according to the early Okuda (0.950 AUC, 84% sensitivity, 99% specificity), CLIP (0.945 AUC, 84% sensitivity, 99% specificity), and BCLC (1.000 AUC, 100% sensitivity, 99% specificity) staging systems. The simplified HCC-ART score was more strongly correlated than AFP and other staging systems with HCC tumor size (P HCC-ART is superior to AFP for diagnosing early-stage HCC. Due to its advantages of minimal variability and a wide continuous scale for assessing HCC severity, the simplified HCC-ART has the potential to be more widely used than the original HCC-ART.

  11. Enhancing the Predicting Accuracy of the Water Stage Using a Physical-Based Model and an Artificial Neural Network-Genetic Algorithm in a River System

    Directory of Open Access Journals (Sweden)

    Wen-Cheng Liu

    2014-06-01

    Full Text Available Accurate simulations of river stages during typhoon events are critically important for flood control and are necessary for disaster prevention and water resources management in Taiwan. This study applies two artificial neural network (ANN models, including the back propagation neural network (BPNN and genetic algorithm neural network (GANN techniques, to improve predictions from a one-dimensional flood routing hydrodynamic model regarding the water stages during typhoon events in the Danshuei River system in northern Taiwan. The hydrodynamic model is driven by freshwater discharges at the upstream boundary conditions and by the water levels at the downstream boundary condition. The model provides a sound physical basis for simulating water stages along the river. The simulated results of the hydrodynamic model show that the model cannot reproduce the water stages at different stations during typhoon events for the model calibration and verification phases. The BPNN and GANN models can improve the simulated water stages compared with the performance of the hydrodynamic model. The GANN model satisfactorily predicts water stages during the training and verification phases and exhibits the lowest values of mean absolute error, root-mean-square error and peak error compared with the simulated results at different stations using the hydrodynamic model and the BPNN model. Comparison of the simulated results shows that the GANN model can be successfully applied to predict the water stages of the Danshuei River system during typhoon events.

  12. The Applicability of the International Staging System in Chinese Patients with Multiple Myeloma Receiving Bortezomib or Thalidomide-Based Regimens as Induction Therapy: A Multicenter Analysis

    Directory of Open Access Journals (Sweden)

    Jing Lu

    2015-01-01

    Full Text Available The International Staging System (ISS is the most important prognostic system for multiple myeloma (MM. It was identified in the era of conventional agents. The outcome of MM has significantly changed by novel agents. Thus the applicability of ISS system in the era of novel agents in Chinese patients needs to be demonstrated. We retrospectively analyzed the clinical outcomes and prognostic significance of ISS system in 1016 patients with newly diagnosed multiple myeloma in Chinese patients between 2008 and 2012, who received bortezomib- or thalidomide-based regimens as first-line therapy. The median overall survival (OS of patients for ISS stages I/II/III was not reached/55.4 months/41.7 months (p<0.001, and the median progression-free survival (PFS was 30/29.5/25 months (p=0.072, respectively. Statistically significant difference in survival was confirmed among three ISS stages in thalidomide-based group, but not between ISS stages I and II in bortezomib-based group. These findings suggest that ISS system can predict the survival in the era of novel agents in Chinese MM patients, and bortezomib may have the potential to partially overcome adverse effect of risk factors on survival, especially in higher stage of ISS system.

  13. A two-stage predictive model to simultaneous control of trihalomethanes in water treatment plants and distribution systems: adaptability to treatment processes.

    Science.gov (United States)

    Domínguez-Tello, Antonio; Arias-Borrego, Ana; García-Barrera, Tamara; Gómez-Ariza, José Luis

    2017-10-01

    The trihalomethanes (TTHMs) and others disinfection by-products (DBPs) are formed in drinking water by the reaction of chlorine with organic precursors contained in the source water, in two consecutive and linked stages, that starts at the treatment plant and continues in second stage along the distribution system (DS) by reaction of residual chlorine with organic precursors not removed. Following this approach, this study aimed at developing a two-stage empirical model for predicting the formation of TTHMs in the water treatment plant and subsequently their evolution along the water distribution system (WDS). The aim of the two-stage model was to improve the predictive capability for a wide range of scenarios of water treatments and distribution systems. The two-stage model was developed using multiple regression analysis from a database (January 2007 to July 2012) using three different treatment processes (conventional and advanced) in the water supply system of Aljaraque area (southwest of Spain). Then, the new model was validated using a recent database from the same water supply system (January 2011 to May 2015). The validation results indicated no significant difference in the predictive and observed values of TTHM (R 2 0.874, analytical variance distribution systems studied, proving the adaptability of the new model to the boundary conditions. Finally the predictive capability of the new model was compared with 17 other models selected from the literature, showing satisfactory results prediction and excellent adaptability to treatment processes.

  14. Staging for vulvar cancer.

    Science.gov (United States)

    Hacker, Neville F; Barlow, Ellen L

    2015-08-01

    Vulvar cancer has been staged by the International Federation of Gynaecology and Obstetrics (FIGO) since 1969, and the original staging system was based on clinical findings only. This system provided a very good spread of prognostic groupings. Because vulvar cancer is virtually always treated surgically, the status of the lymph nodes is the most important prognostic factor and this can only be determined with certainty by histological examination of resected lymph nodes, FIGO introduced a surgical staging system in 1988. This was modified in 1994 to include a category of microinvasive vulvar cancer (stage IA), because such patients have virtually no risk of lymph node metastases. This system did not give a reasonably even spread of prognostic groupings. In addition, patients with stage III disease were shown to be a heterogeneous group prognostically, and the number of positive nodes and the morphology of those nodes were not taken into account. A new surgical staging system for vulvar cancer was introduced by FIGO in 2009. Initial retrospective analyses have suggested that this new staging system has overcome the major deficiencies in the 1994 system. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  15. Instrumentation, methods of flood-data collection and transmission, and evaluation of streamflow-gaging network in Indiana

    Science.gov (United States)

    Glatfelter, D.R.; Butch, G.K.

    1994-01-01

    Floods are the number one natural disaster in the Nation, based on loss of life and property. In Indiana, several major floods have occurred during this century. Flooding can occur at any time in any geographic area in Indiana. The degree of flooding can vary from a minor inconvenience to major flooding that results in loss of life and extensive damage. In this study, the existing streamflow-gaging networks in Indiana are evaluated on the basis of meeting flood-data needs of various governmental agencies.

  16. Improving snow water equivalent simulations in an alpine basin using blended gage precipitation and snow pillow measurements

    Science.gov (United States)

    Sohrabi, M.; Safeeq, M.; Conklin, M. H.

    2017-12-01

    Snowpack is a critical freshwater reservoir that sustains ecosystem, natural habitat, hydropower, agriculture, and urban water supply in many areas around the world. Accurate estimation of basin scale snow water equivalent (SWE), through both measurement and modeling, has been significantly recognized to improve regional water resource management. Recent advances in remote data acquisition techniques have improved snow measurements but our ability to model snowpack evolution is largely hampered by poor knowledge of inherently variable high-elevation precipitation patterns. For a variety of reasons, majority of the precipitation gages are located in low and mid-elevation range and function as drivers for basin scale hydrologic modeling. Here, we blend observed gage precipitation from low and mid-elevation with point observations of SWE from high-elevation snow pillow into a physically based snow evolution model (SnowModel) to better represent the basin-scale precipitation field and improve snow simulations. To do this, we constructed two scenarios that differed in only precipitation. In WTH scenario, we forced the SnowModel using spatially distributed gage precipitation data. In WTH+SP scenario, the model was forced with spatially distributed precipitation data derived from gage precipitation along with observed precipitation from snow pillows. Since snow pillows do not directly measure precipitation, we uses positive change in SWE as a proxy for precipitation. The SnowModel was implemented at daily time step and 100 m resolution for the Kings River Basin, USA over 2000-2014. Our results show an improvement in snow simulation under WTH+SP as compared to WTH scenario, which can be attributed to better representation in high-elevation precipitation patterns under WTH+SP. The average Nash Sutcliffe efficiency over all snow pillow and course sites was substantially higher for WTH+SP (0.77) than for WTH scenario (0.47). The maximum difference in observed and simulated

  17. Force Reconstruction from Ejection Tests of Stores from Aircraft Used for Model Predictions and Missing/Bad Gages

    Energy Technology Data Exchange (ETDEWEB)

    Ross, Michael; Cap, Jerome S.; Starr, Michael J.; Urbina, Angel; Brink, Adam Ray

    2015-12-01

    One of the more severe environments for a store on an aircraft is during the ejection of the store. During this environment it is not possible to instrument all component responses, and it is also likely that some instruments may fail during the environment testing. This work provides a method for developing these responses from failed gages and uninstrumented locations. First, the forces observed by the store during the environment are reconstructed. A simple sampling method is used to reconstruct these forces given various parameters. Then, these forces are applied to a model to generate the component responses. Validation is performed on this methodology.

  18. The leptin system and its expression at different nutritional and pregnant stages in lined seahorse (Hippocampus erectus

    Directory of Open Access Journals (Sweden)

    Huixian Zhang

    2016-10-01

    Full Text Available Leptin is an essential hormone for the regulation of energy metabolism and food intake in vertebrate animals. To better understand the physiological roles of leptin in nutrient regulation in paternal ovoviviparous fish (family Syngnathidae, the present study cloned the full-length of leptin-a and leptin receptor (lepr genes in lined seahorse (Hippocampus erectus. Results showed that there was a 576-bp intron between two exons in leptin-a gene but no leptin-b gene in seahorse. Although the primary amino acid sequence conservation of seahorse leptin-a was very low, the 3-D structure modeling of seahorse leptin-a revealed strong conservation of tertiary structure with other vertebrates. Seahorse leptin-a mRNA was highly expressed in brain, whereas lepr mRNA was mainly expressed in ovary and gill. Interestingly, both leptin-a and lepr mRNA were expressed in the brood pouch of male seahorse, suggesting the leptin system plays a role during the male pregnancy. Physiological experiments showed that the expression of hepatic leptin-a and lepr mRNA in unfed seahorses was significantly higher than that in those fed 100%, as well as 60%, of their food during the fasting stage, showing that seahorse might initiate the leptin system to regulate its energy metabolism while starving. Moreover, the expression of leptin-a in the brood pouch of pregnant seahorse was significantly upregulated compared with non-pregnant seahorse, whereas the expression of lepr was downregulated, suggesting that the leptin system might be involved in the male pregnancy. In conclusion, the leptin system plays a role in the energy metabolism and food intake, and might provide new insights into molecular regulation of male pregnancy in seahorse.

  19. Preoperative indication for systemic therapy extended to patients with early-stage breast cancer using multiparametric 7-tesla breast MRI.

    Directory of Open Access Journals (Sweden)

    A M T Schmitz

    Full Text Available To establish a preoperative decision model for accurate indication of systemic therapy in early-stage breast cancer using multiparametric MRI at 7-tesla field strength.Patients eligible for breast-conserving therapy were consecutively included. Patients underwent conventional diagnostic workup and one preoperative multiparametric 7-tesla breast MRI. The postoperative (gold standard indication for systemic therapy was established from resected tumor and lymph-node tissue, based on 10-year risk-estimates of breast cancer mortality and relapse using Adjuvant! Online. Preoperative indication was estimated using similar guidelines, but from conventional diagnostic workup. Agreement was established between preoperative and postoperative indication, and MRI-characteristics used to improve agreement. MRI-characteristics included phospomonoester/phosphodiester (PME/PDE ratio on 31-phosphorus spectroscopy (31P-MRS, apparent diffusion coefficients on diffusion-weighted imaging, and tumor size on dynamic contrast-enhanced (DCE-MRI. A decision model was built to estimate the postoperative indication from preoperatively available data.We included 46 women (age: 43-74yrs with 48 invasive carcinomas. Postoperatively, 20 patients (43% had positive, and 26 patients (57% negative indication for systemic therapy. Using conventional workup, positive preoperative indication agreed excellently with positive postoperative indication (N = 8/8; 100%. Negative preoperative indication was correct in only 26/38 (68% patients. However, 31P-MRS score (p = 0.030 and tumor size (p = 0.002 were associated with the postoperative indication. The decision model shows that negative indication is correct in 21/22 (96% patients when exempting tumors larger than 2.0cm on DCE-MRI or with PME>PDE ratios at 31P-MRS.Preoperatively, positive indication for systemic therapy is highly accurate. Negative indication is highly accurate (96% for tumors sized ≤2,0cm on DCE-MRI and with PME

  20. Continuous power generation and microbial community structure of the anode biofilms in a three-stage microbial fuel cell system

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Kyungmi; Okabe, Satoshi [Hokkaido Univ., Sapporo (Japan). Dept. of Urban and Environmental Engineering

    2009-07-15

    A mediator-less three-stage two-chamber microbial fuel cell (MFC) system was developed and operated continuously for more than 1.5 years to evaluate continuous power generation while treating artificial wastewater containing glucose (10 mM) concurrently. A stable power density of 28 W/m3 was attained with an anode hydraulic retention time of 4.5 h and phosphate buffer as the cathode electrolyte. An overall dissolved organic carbon removal ratio was about 85%, and coulombic efficiency was about 46% in this MFC system. We also analyzed the microbial community structure of anode biofilms in each MFC. Since the environment in each MFC was different due to passing on the products to the next MFC in series, the microbial community structure was different accordingly. The anode biofilm in the first MFC consisted mainly of bacteria belonging to the Gammaproteobacteria, identified as Aeromonas sp., while the Firmicutes dominated the anode biofilms in the second and third MFCs that were mainly fed with acetate. Cyclic voltammetric results supported the presence of a redox compound(s) associated with the anode biofilm matrix, rather than mobile (dissolved) forms, which could be responsible for the electron transfer to the anode. Scanning electron microscopy revealed that the anode biofilms were comprised of morphologically different cells that were firmly attached on the anode surface and interconnected each other with anchor-like filamentous appendages, which might support the results of cyclic voltammetry. (orig.)

  1. Two-stage gene regulation of the superoxide stress response soxRS system in Escherichia coli.

    Science.gov (United States)

    Nunoshiba, T

    1996-01-01

    All organisms have adapted to environmental changes by acquiring various functions controlled by gene regulation. In bacteria, a number of specific responses have been found to confer cell survival in various nutrient-limited conditions, and under physiological stresses such as high or low temperature, extreme pH, radiation, and oxidation (for review, see Neidhardt et al., 1987). In this article, I introduce an Escherichia coli (E. coli) global response induced by superoxide stress, the soxRS regulon. The functions controlled by this system consist of a wide variety of enzymes such as manganese-containing SOD (Mn-SOD); glucose 6-phosphate dehydrogenase (G6PD), the DNA repair enzyme endonuclease IV, fumarase C, NADPH:ferredoxin oxidoreductase, and aconitase. This response is positively regulated by a two-stage control system in which SoxR iron-sulfur protein senses exposure to superoxide and nitric oxide, and then activates transcription of the soxS gene, whose product stimulates the expression of the regulon genes. Our recent finding indicates that soxS transcription is initiated in a manner dependent on the rpoS gene encoding RNA polymerase sigma factor, theta s, in response to entering the stationary phase of growth. With this information, mechanisms for prokaryotic coordinating gene expression in response to superoxide stress and in stationary phase are discussed.

  2. High Precision Motion Control System for the Two-Stage Light Gas Gun at the Dynamic Compression Sector

    Science.gov (United States)

    Zdanowicz, E.; Guarino, V.; Konrad, C.; Williams, B.; Capatina, D.; D'Amico, K.; Arganbright, N.; Zimmerman, K.; Turneaure, S.; Gupta, Y. M.

    2017-06-01

    The Dynamic Compression Sector (DCS) at the Advanced Photon Source (APS), located at Argonne National Laboratory (ANL), has a diverse set of dynamic compression drivers to obtain time resolved x-ray data in single event, dynamic compression experiments. Because the APS x-ray beam direction is fixed, each driver at DCS must have the capability to move through a large range of linear and angular motions with high precision to accommodate a wide variety of scientific needs. Particularly challenging was the design and implementation of the motion control system for the two-stage light gas gun, which rests on a 26' long structure and weighs over 2 tons. The target must be precisely positioned in the x-ray beam while remaining perpendicular to the gun barrel axis to ensure one-dimensional loading of samples. To accommodate these requirements, the entire structure can pivot through 60° of angular motion and move 10's of inches along four independent linear directions with 0.01° and 10 μm resolution, respectively. This presentation will provide details of how this system was constructed, how it is controlled, and provide examples of the wide range of x-ray/sample geometries that can be accommodated. Work supported by DOE/NNSA.

  3. Development of a system based in a digital signal processor (DSP) for a simulator of power regulation in a reactor: first stage

    International Nuclear Information System (INIS)

    Benitez R, J.S.; Perez C, B.

    2002-01-01

    The first stage of the development of a digital system based on a DSP is presented which forms part of an hybrid simulator for the power regulation in am model of the punctual kinetics of a TRIGA reactor type. The DSP performs the regulation, using a Mandami type algorithm of diffuse control. In the algorithm, the universe of the output variable is discretized for performing in an unique stage the aggregation functions and dis-diffusization. (Author)

  4. Determining the stages of tillering stage, initiation of primordia, flowering and maturity in the rice plant, with the system S, V and R correlated with the thermal sum at the time

    Directory of Open Access Journals (Sweden)

    Jennifer Velázquez

    2015-11-01

    Full Text Available Temperature is one of the major climatic factors that affect growth, development and yield of the rice crop, and also can reduce the time of change of phenological stages. The beginning stages of tillering, initiation of primordia, flowering and harvest maturity were determined with the S, V and R system recently proposed by Counce et ál. (2000; it consists on counting the number of fully developed leaves; in addition, a correlation was made with accumulated degree days that the plant had at that time, in order to estimate with how many degree days the plant began a phenological stage; this parameter is related to the average daily temperature and a base temperature of 10ºC. For the start of tillering the plant needed 140.9 degree days; for primordium start, 1268.9; for bloom 1746; and completed its cycle with a total of 2333.2 degree days. This allows to conclude that, for a variety of long cycle (130-135 days, when the accumulation of degree days is equal or similar to the previous data, the plant initiates one of the above-mentioned phenological stages; however, each one of the varieties in use by farmers must be calibrated, because there are differences in crop cycle length among them.

  5. Unraveling the different toxic effect of flufenoxuron on the thyroid endocrine system of the Mongolia racerunner (Eremias Argus) at different stages.

    Science.gov (United States)

    Chang, Jing; Li, Wei; Guo, Baoyuan; Xu, Peng; Wang, Yinghuan; Li, Jianzhong; Wang, Huili

    2017-04-01

    Flufenoxuron is a widely used pesticide to inhibit the synthesis of chitin during insect development and its effect on the growth of lizards has been little addressed. The hypothalamus-pituitary-thyroid (HPT) axis plays an important role on the development of lizards. In this study, the lizards at different development stages (proliferation and resting stages) were exposed to flufenoxuron for 21 days. The plasma thyroid hormone levels, thyroid gland histopathology and expression profiles of thyroid hormone receptors (trα, trβ), deiodinases (dio1, dio2), and transthyretin (ttr) genes were measured to evaluated the toxic effect of flufenoxuron on the HPT axis at different stages. The flufenoxuron exposure showed more seriously effect on the triiodothyronine (T3) level at resting phase than that at proliferation stage. The follicle epithelium cell height in the thyroid was only significantly increased when the exposed male lizards were at proliferation stage. The alteration of HPT axis-related genes expression was gender and tissue dependent after flufenoxuron treatment. The lizards exposed to flufenoxuron showed that the trα, trβ, dio1, dio2, and ttr genes in the female liver were more sensitive at the proliferation stage than that at the resting stage. In the male brain, the expressions of trα, trβ, dio1, and dio2 gene were significant decreased at proliferation stage while significant increased at resting stage after flufenoxuron exposure. Therefore, the thyroid endocrine system of lizards could be affected by the flufenoxuron exposure and the different development stage should also be considered when study the toxic effect of contaminants on the lizards. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. {sup 18}F-FDG-PET/CT for systemic staging of patients with newly diagnosed ER-positive and HER2-positive breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ulaner, Gary A.; Castillo, Raychel [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Weill Cornell Medical College, Department of Radiology, New York, NY (United States); Wills, Jonathan [Memorial Sloan Kettering Cancer Center, Department of Information Systems, New York, NY (United States); Goenen, Mithat; Goldman, Debra A. [Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY (United States)

    2017-08-15

    This study assesses {sup 18}F-FDG-PET/CT for patients with newly diagnosed estrogen receptor-positive/human epidermal growth factor receptor-negative (ER+/HER2-) and human epidermal growth factor receptor-positive (HER2+) breast cancer. In this Institutional Review Board-approved retrospective study, our Healthcare Information System was screened for patients with ER+/HER2- and HER2+ breast cancer who underwent {sup 18}F-FDG-PET/CT prior to systemic or radiation therapy. The initial stage was determined from mammography, ultrasound, magnetic resonance imaging, and/or surgery.{sup 18}F-FDG-PET/CT was evaluated to identify unsuspected extra-axillary regional nodal and distant metastases. The proportion of patients upstaged overall and stratified by stage and receptor phenotypes was calculated along with confidence intervals (CI). A total of 238 patients with ER+/HER2- and 245 patients with HER2+ who met inclusion criteria were evaluated. For patients with ER+/HER2-breast cancer, {sup 18}F-FDG-PET/CT revealed unsuspected distant metastases in 3/71 (4%) initial stage IIA, 13/95 (14%) stage IIB, and 15/57 (26%) stage III. For patients with HER2+ breast cancer, {sup 18}F-FDG-PET/CT revealed unsuspected distant metastases in 3/72 (4%) initial stage IIA, 13/93 (14%) stage IIB, and 13/59 (22%) stage III. The overall upstaging rate for IIB was 14% (95% confidence interval (CI): 9-20%). {sup 18}F-FDG-PET/CT revealed distant metastases in 14% (95% CI: 9-20%) of patients with stage IIB ER+/HER2- and HER2+ breast cancer, which is similar to upstaging rates previously seen in patients with stage IIB triple-negative breast cancer (15%, 95% CI: 9-24%). The detection of unsuspected distant metastases in these patients alters treatment and prognosis. NCCN guidelines should consider adding patients with stage IIB breast cancer for consideration of systemic staging with {sup 18}F-FDG-PET/CT at the time of initial diagnosis. (orig.)

  7. Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update

    Science.gov (United States)

    Masters, Gregory A.; Temin, Sarah; Azzoli, Christopher G.; Giaccone, Giuseppe; Baker, Sherman; Brahmer, Julie R.; Ellis, Peter M.; Gajra, Ajeet; Rackear, Nancy; Schiller, Joan H.; Smith, Thomas J.; Strawn, John R.; Trent, David; Johnson, David H.

    2015-01-01

    Purpose To provide evidence-based recommendations to update the American Society of Clinical Oncology guideline on systemic therapy for stage IV non–small-cell lung cancer (NSCLC). Methods An Update Committee of the American Society of Clinical Oncology NSCLC Expert Panel based recommendations on a systematic review of randomized controlled trials from January 2007 to February 2014. Results This guideline update reflects changes in evidence since the previous guideline. Recommendations There is no cure for patients with stage IV NSCLC. For patients with performance status (PS) 0 to 1 (and appropriate patient cases with PS 2) and without an EGFR-sensitizing mutation or ALK gene rearrangement, combination cytotoxic chemotherapy is recommended, guided by histology, with early concurrent palliative care. Recommendations for patients in the first-line setting include platinum-doublet therapy for those with PS 0 to 1 (bevacizumab may be added to carboplatin plus paclitaxel if no contraindications); combination or single-agent chemotherapy or palliative care alone for those with PS 2; afatinib, erlotinib, or gefitinib for those with sensitizing EGFR mutations; crizotinib for those with ALK or ROS1 gene rearrangement; and following first-line recommendations or using platinum plus etoposide for those with large-cell neuroendocrine carcinoma. Maintenance therapy includes pemetrexed continuation for patients with stable disease or response to first-line pemetrexed-containing regimens, alternative chemotherapy, or a chemotherapy break. In the second-line setting, recommendations include docetaxel, erlotinib, gefitinib, or pemetrexed for patients with nonsquamous cell carcinoma; docetaxel, erlotinib, or gefitinib for those with squamous cell carcinoma; and chemotherapy or ceritinib for those with ALK rearrangement who experience progression after crizotinib. In the third-line setting, for patients who have not received erlotinib or gefitinib, treatment with erlotinib is

  8. International prognostic index (IPI)--a critical comparison with five multiple myeloma staging systems in the group of 270 patients treated by conventional chemotherapy.

    Science.gov (United States)

    Scudla, V; Zemanova, M; Minarik, J; Bacovsky, J; Ordeltova, M; Indrak, K; Budikova, M; Dusek, L; Farbiakova, V

    2006-01-01

    In the group of 270 patients with multiple myeloma (MM) treated during 1991-2004 by conventional chemotherapy, the prognostic value and practical utility of IPI (International Prognostic Index) was assessed and compared with five other actual staging systems. Prognostic significance was assessed using the curves of overall survival (OS) according to Kaplan-Meier and log rank test (pIPI (pIPI (median OS 77, 76 and 77 months). To select a cohort of "high risk" patients, i.e. stage 3, with very unfavourable disease prognosis, the most advantageous was the system OSS and San Miguel (median OS was 5 and 6 months) and/or SWOG system selecting patients of stage 4, i.e. "worst prognosis", with median OS 8 months. It was found that IPI did not meet expectations for effective identification of "high risk" patients (median OS of stage 3 was 20 months) nor for the distinction of different prognosis of patients during initial 25 months of MM course at stage 2 vs. 3. The study indicates that under conditions of common clinical practice and conventional chemotherapy, the staging system according to D-S is still useful, while practical application of SWOG and IPI as simpler alternative to the assessment of clinical stage should be verified by further comparative studies. In harmony with the progress in cytogenetics and molecular biology as well as a prospective requirement of individual target therapy, a future suitable stratification system should be based on parameters of internal biological properties of myeloma tissue and microenvironment of bone marrow, allowing in addition a continuous evaluation of the disease course and the effect of therapy.

  9. Staging atmospheres

    DEFF Research Database (Denmark)

    Bille, Mikkel; Bjerregaard, Peter; Sørensen, Tim Flohr

    2015-01-01

    The article introduces the special issue on staging atmospheres by surveying the philosophical, political and anthropological literature on atmosphere, and explores the relationship between atmosphere, material culture, subjectivity and affect. Atmosphere seems to occupy one of the classic...

  10. Prognostic value of the serum free light chain ratio in newly diagnosed myeloma: proposed incorporation into the international staging system.

    Science.gov (United States)

    Snozek, C L H; Katzmann, J A; Kyle, R A; Dispenzieri, A; Larson, D R; Therneau, T M; Melton, L J; Kumar, S; Greipp, P R; Clark, R J; Rajkumar, S V

    2008-10-01

    To determine if the serum free light chain (FLC) ratio has prognostic value in patients with symptomatic multiple myeloma (MM), baseline serum samples from a well-characterized cohort of 790 newly diagnosed MM patients were tested with the FLC assay. FLC ratio was calculated as kappa/lambda (reference range 0.26-1.65). On the basis of the distribution of values, a cutpoint kappa/lambda FLC ratio of 32 was chosen for further analysis. Overall survival was significantly inferior in patients with an abnormal FLC ratio of 32 (n=479) compared with those with an FLC ratio between 0.03 and 32 (n=311), with median survival of 30 versus 39 months, respectively. We incorporated abnormal FLC ratio with the International Staging System (ISS) risk factors (that is, albumin or=3.5 g/l), to create a risk stratification model with improved prognostic capabilities. Patients with 0, 1, 2 or 3 adverse risk factors had significantly different overall survival, with median survival times of 51, 39, 30 and 22 months, respectively (P<0.001). These findings suggest that the serum FLC ratio at initial diagnosis is an important predictor of prognosis in myeloma, and can be incorporated into the ISS for improved risk stratification.

  11. Optimal design of the first stage of the plate-fin heat exchanger for the EAST cryogenic system

    Science.gov (United States)

    Qingfeng, JIANG; Zhigang, ZHU; Qiyong, ZHANG; Ming, ZHUANG; Xiaofei, LU

    2018-03-01

    The size of the heat exchanger is an important factor determining the dimensions of the cold box in helium cryogenic systems. In this paper, a counter-flow multi-stream plate-fin heat exchanger is optimized by means of a spatial interpolation method coupled with a hybrid genetic algorithm. Compared with empirical correlations, this spatial interpolation algorithm based on a kriging model can be adopted to more precisely predict the Colburn heat transfer factors and Fanning friction factors of offset-strip fins. Moreover, strict computational fluid dynamics simulations can be carried out to predict the heat transfer and friction performance in the absence of reliable experimental data. Within the constraints of heat exchange requirements, maximum allowable pressure drop, existing manufacturing techniques and structural strength, a mathematical model of an optimized design with discrete and continuous variables based on a hybrid genetic algorithm is established in order to minimize the volume. The results show that for the first-stage heat exchanger in the EAST refrigerator, the structural size could be decreased from the original 2.200 × 0.600 × 0.627 (m3) to the optimized 1.854 × 0.420 × 0.340 (m3), with a large reduction in volume. The current work demonstrates that the proposed method could be a useful tool to achieve optimization in an actual engineering project during the practical design process.

  12. A Power Conditioning Stage Based on Analog-Circuit MPPT Control and a Superbuck Converter for Thermoelectric Generators in Spacecraft Power Systems

    Science.gov (United States)

    Sun, Kai; Wu, Hongfei; Cai, Yan; Xing, Yan

    2014-06-01

    A thermoelectric generator (TEG) is a very important kind of power supply for spacecraft, especially for deep-space missions, due to its long lifetime and high reliability. To develop a practical TEG power supply for spacecraft, a power conditioning stage is indispensable, being employed to convert the varying output voltage of the TEG modules to a definite voltage for feeding batteries or loads. To enhance the system reliability, a power conditioning stage based on analog-circuit maximum-power-point tracking (MPPT) control and a superbuck converter is proposed in this paper. The input of this power conditioning stage is connected to the output of the TEG modules, and the output of this stage is connected to the battery and loads. The superbuck converter is employed as the main circuit, featuring low input current ripples and high conversion efficiency. Since for spacecraft power systems reliable operation is the key target for control circuits, a reset-set flip-flop-based analog circuit is used as the basic control circuit to implement MPPT, being much simpler than digital control circuits and offering higher reliability. Experiments have verified the feasibility and effectiveness of the proposed power conditioning stage. The results show the advantages of the proposed stage, such as maximum utilization of TEG power, small input ripples, and good stability.

  13. Integrating end-user feedback in the concept stage of development of a novel sensor access system for environmental control.

    Science.gov (United States)

    Fager, Susan Koch; Sorenson, Tabatha; Butte, Susanne; Nelson, Alexander; Banerjee, Nilanjan; Robucci, Ryan

    2018-05-01

    This article illustrates user-centred design of a novel sensor access system for environmental control in the concept stage of development. Focus groups of individuals with disabilities and rehabilitation healthcare professionals were provided with video illustration of the technology and asked to provide quantitative and qualitative feedback through a semistructured interview process. Qualitative methods were employed to analyse transcribed comments to develop themes supporting ongoing development of the technology. Both end-user streams rated the original design features of the sensor access system (alternative interface to assistive technologies, having wireless capabilities and not requiring batteries) as having high potential value. Both groups identified a need for the future design of the sensor technology to be able to capture minimal/reduced movements for those with severe physical impairments. Themes included (1) the sensor technology could be individualized/customized to accommodate the user, (2) minimal positioning and set-up requirement and (3) technology that alleviated problems encountered with touch-based solutions. Inclusion of end-user feedback provided the research team with valuable information that supported the initial conceptualization of the design features of the technology and provided valuable data to support development of a new prototype that can capture more reduced/minimal movements. Implication for Rehabilitation User-centered design of assistive technology is essential to the development of technology that can meet the unique needs of those with the most severe physical impairments. New sensor technology may alleviate some of the access challenges faced by individuals with severe physical impairments. Collaboration between all key stakeholders (individuals with disabilities, rehabilitation professionals, researchers, and developers) is an essential component in the iterative assistive technology design process.

  14. Dynamic modelling of a one-stage spur gear system and vibration-based tooth crack detection analysis

    Science.gov (United States)

    Mohammed, Omar D.; Rantatalo, Matti; Aidanpää, Jan-Olov

    2015-03-01

    For the purpose of simulation and vibration-based condition monitoring of a geared system, it is important to model the system with an appropriate number of degrees of freedom (DOF). In earlier papers several models were suggested and it is therefore of interest to evaluate their limitations. In the present study a 12 DOF gear dynamic model including a gyroscopic effect was developed and the equations of motions were derived. A one-stage reduction gear was modelled using three different dynamic models (with 6, 8 and 8 reduced to 6 DOF), as well as the developed model (with 12 DOF), which is referred as the fourth model in this paper. The time-varying mesh stiffness was calculated, and dynamic simulation was then performed for different crack sizes. Time domain scalar indicators (the RMS, kurtosis and the crest factor) were applied for fault detection analysis. The results of the first model show a clearly visible difference from those of the other studied models, which were made more realistic by including two more DOF to describe the motor and load. Both the symmetric and the asymmetric disc cases were studied using the fourth model. In the case of disc symmetry, the results of the obtained response are close to those obtained from both the second and third models. Furthermore, the second model showed a slight influence from inter-tooth friction, and therefore the third model is adequate for simulating the pinion's y-displacement in the case of the symmetric disc. In the case of the asymmetric disc, the results deviate from those obtained in the symmetric case. Therefore, for simulating the pinion's y-displacement, the fourth model can be considered for more accurate modelling in the case of the asymmetric disc.

  15. [Application of minimally invasive, decompression bone graft implantation combined with metal trabecular bone reconstruction system for early stage osteonecrosis of femoral head].

    Science.gov (United States)

    Chen, Xian-tao; Tan, Xu-yi; Liu, You-wen; Zhang, Xiao-dong; Liu, Li-yun; Jia, Yu-dong

    2015-05-01

    To observe the application effect of minimally invasive decompression, bone graft implantation and metal trabecular bone reconstruction system for early stage osteonecrosis of femoral head and discuss the treatment of hip-salvage operation in early stage osteonecrosis of femoral head; From January 2010 to June 2011, 50 patients (62 hips) Which were osteonecrosis of femoral head of early stake,were treated with minimally invasive decompression, bone graft implantation and metal trabecular bone reconstruction system, including 31 males (40 hips), 19 females (22 hip) with an average age of 36.2 years old ranging from 22 to 54 years old. The course of disease was from 6 to 15 months (averaged 10.5 months). Among them, 19 cases (23 hips) were steroid-induced, 25 cases (33 hips) were alcohol-induced, 6 cases (6 hips) were idiopathic; According to ARCO stage, 28 hips were at stage I, 34 hips were at stage II. All of them were diagnosed as femoral head necrosis by imaging examination before operation. Then each patient was followed to assess by Harris hip score, curative effect, and conduct the femoral head survival analysis during the postoperation. All patients had finished operation, the operation time was between 30 and 85 min, intraoperative blood loss was 50 to 220 ml, and 47 cases (58 hips) were follow-up from 24 to 46 months with an average of 34.05 months. As compared with preoperative, the Harris hip score at the last follow-up was improved, the difference was statistically significant (Pfemoral head in ARCO stage I was superior to these in ARCO Stage II, the difference was statistically significant (Posteonecrosis of femoral head was good,it could significantly improve the Harris hip score, increase the femoral head survival time, delay the hip replacement, and performance better in ARCO stage I.

  16. The 'GO' system--a novel method of microculture for in vitro development of mouse zygotes to the blastocyst stage.

    Science.gov (United States)

    Thouas, G A; Jones, G M; Trounson, A O

    2003-08-01

    A novel system of in vitro culture termed the 'glass oviduct' or 'GO' culture system is described. Mouse zygotes were cultured in pairs to the blastocyst stage in open-ended 1 microl glass capillaries. 'GO' culture supported the development of significantly more hatching or hatched blastocysts than did a standard microdroplet (10 zygotes per 20 microl) control culture (48.3 versus 3.3%, respectively). 'GO' bslastocysts contained significantly larger populations of cells (92+/-3 versus 75+/-3), and inner cell mass (25+/-1 versus 21+/-1) and trophectoderm (68+/-2 versus 53+/-3) subpopulations, compared with microdroplet-derived blastocysts. Before blastulation, 'GO'-derived morulae were found to contain significantly more cells than microdroplet-derived morulae (27+/-0.7 versus 14+/-0.5). After implantation, 'GO' blastocysts formed fetuses at a similar rate to microdroplet-derived blastocysts (55 versus 62%), but at a lower rate than blastocysts derived in vivo (80%). 'GO'- and microdroplet-derived fetuses were similar in wet weight to each other (0.412 and 0.415 g, respectively) but were heavier than fetuses derived from flushed blastocysts (0.390 g). An additional experiment investigated whether the beneficial effect of 'GO' culture was due to the significantly increased embryo density. Proportions of hatching or hatched blastocysts after 'GO' culture (50%) were higher than after standard microdroplet culture (7.6%), but were not different from culture in high embryo density microdroplets (20 zygotes per 10 microl; 42%). 'GO' blastocysts contained more cells (79.6+/-2.1) than did standard microdroplet-derived blastocysts (68.7+/-2.0), but were similar to high density microdroplet-derived blastocysts (85.8+/-2.7). Similarly, 'GO' blastocysts contained more trophectoderm cells (62.2+/-2.0) than did standard microdroplet-derived blastocysts (52.7+/-1.7), but were similar to the high density microdroplet blastocysts (68.8+/-2.5). Numbers of inner cell mass cells ('GO

  17. Development and testing of a three-stage double tandem accelerator-decelerator system for low energy, highly stripped ions. Progress report, March 1, 1978--February 28, 1979

    International Nuclear Information System (INIS)

    Bayfield, J.E.

    1978-11-01

    Three-stage operation of the University of Pittsburgh accel-decel double tandem source of highly stripped ion beams is described. The system has produced O 5+ , O 6+ , O 7+ , and O 8+ ions at specific energies as low as 15 keV per AMU. The design of the new decelerator tubes is discussed. The present performance and limitations of the overall system are outlined. Some new charge exchange cross sections have been measured, for combined higher ion charge states and lower ion energies than heretofore was possible. Future four-stage operation with very heavy ions is considered

  18. Development and testing of a three-stage double tandem accelerator-decelerator system for low energy, highly stripped ions. Progress report, March 1, 1978--February 28, 1979

    International Nuclear Information System (INIS)

    Bayfield, J.E.

    1978-11-01

    Three-stage operation of the University of Pittsburgh accel-decel double tandem source of highly stripped ion beams is described. The system has produced 0 5+ , 0 6+ , 0 7+ , and 0 8+ ions at specific energies as low as 15 keV per AMU. The design of the new decelerator tubes is discussed. The present performance and limitations of the overall system are outlined. Some new charge exchange cross sections have been measured, for combined higher ion charge states and lower ion energies than heretofore was possible. Future four-stage operation with very heavy ions is considered

  19. The impact of posttraumatic stress disorder versus resilience on nocturnal autonomic nervous system activity as functions of sleep stage and time of sleep

    OpenAIRE

    Kobayashi, Ihori; Lavela, Joseph; Bell, Kimberly; Mellman, Thomas A.

    2016-01-01

    Posttraumatic stress disorder (PTSD) has been associated with sleep disturbances including alterations in sleep stages and recently, elevated nocturnal autonomic nervous system (ANS) arousal (i.e., dominance of the sympathetic nervous system over the parasympathetic nervous system). Data suggest that sleep contributes to the regulation of ANS activity. In our previous ambulatory heart rate variability (HRV) monitoring study, strong relationships between sleep and nocturnal ANS activity in res...

  20. SMOKING’S ROLE IN THE PATHOGENESIS OF BRONCHIAL AND SYSTEMIC INFLAMMATION AT THE INITIAL STAGE COPD

    Directory of Open Access Journals (Sweden)

    A. E. Shuganov

    2017-01-01

    Full Text Available COPD is characterized by a pathological inflammatory response in the lungs. Inflammation is qualitatively and quantitatively different from that  of smokers and persons without nicotine addiction. There is evidence for the presence of systemic inflammation in COPD, which probably originates in the lungs. Immune system was investigated on the basis of blood cytotoxic lymphocytes such as cytotoxic T — lymphocytes and NK — cells in patients with COPD 2 tbsp. The study included 42 patients with COPD severity according to 2 g (22 GOLD 2014 criteria. 22 patients with COPD 2 tbsp had smoking index of at least 20 pack \\ years and 20 patients who had never smoked. In all patients, there were no data on atopy and asthma history. All surveyed patients received inhaled M-holinolitik — tiotropium bromide monohydrate 18 micrograms, and on-demand short-acting bronchodilators for 2 breaths. Age of patients was 1 group (smokers from 50 to 62 years (mean age 54,1±1,3 years .2 The second group — 58-75 years (58,21±0,7 years. By indirect immunofluorescence  were determined  relative and absolute  content  in peripheral blood lymphocytes, ekspresiruyuschie antigens CD3, CD4, CD16, CD20, CD23, CD25, CD54, CD71, CD72, HLA-DR, CD95, membrane  immunoglobulin mIgM and mIgG. As a result of the study it was found that  patients  in the early stages of COPD 2 tbsp. there was a significant change in blood levels of cytotoxic lymphocytes,  regardless of the addiction to smoking. But when smoking signs “oxidative stress” are more pronounced,  resulting in a more rapid and possibly further more severe course of the disease. Thus, COPD is characterized by the development  of systemic inflammation, however, the underlying mechanisms, as well as the desirability and feasibility of the suppression of inflammatory processes require further study.

  1. First-line systemic treatment of advanced stage non-small-cell lung cancer in Asia: consensus statement from the Asian Oncology Summit 2009.

    Science.gov (United States)

    Soo, Ross A; Anderson, Benjamin O; Cho, Byoung Chul; Yang, Chih-Hsin; Liao, Meilin; Lim, Wan-Teck; Goldstraw, Peter; Mok, Tony S

    2009-11-01

    Non-small-cell lung cancer (NSCLC) is an increasing global challenge, especially in low-income countries. Most guidelines for the management of advanced-stage NSCLC have limited effect in countries with resource constraints. Following a systematic literature search, we present an overview of the management of advanced-stage NSCLC in the first-line setting, discuss resources required for systemic therapy, and provide treatment recommendations stratified to four resources levels. Treatment guidelines appropriate for different resource levels offer a realistic approach to management of advanced-stage NSCLC, by recognising the limitations of a particular health-care system. Although there are many barriers to cancer control in low-resource countries, these can be overcome by using measures that are culturally appropriate, economically feasible, and evidence-based. Initiatives include strategic planning, tobacco control, training of health-care workers, access to therapeutic agents, acquisition of information, public education, and alliances with established institutions and international organisations.

  2. Technical procedures for water resources, Deaf Smith County site, Texas: Volume 1: Environmental Field Program: Final draft

    International Nuclear Information System (INIS)

    1987-08-01

    This volume contains Technical Procedures pursuant to the Water Resources Site Study Plan including, determination of basin topographic characteristics, determination of channel and playa lake characteristics, operation of a stream gaging station, operation of a playa lake stage gaging system, and processing of data from a playa lake stage gaging system

  3. The international staging system improves the IPI risk stratification in patients with diffuse large B-cell lymphoma treated with R-CHOP.

    Science.gov (United States)

    Wei, Xiaolei; Hao, Xiaoxiao; Zhou, Lizhi; Wei, Qi; Zhang, Yuankun; Huang, Weimin; Song, Jialin; Feng, Ru; Wei, Yongqiang

    2017-10-19

    The international staging system (ISS), based on serum beta-2 microglobulin and albumin, is used to predict survival in multiple myeloma, but its prognostic significance in diffuse large B-cell lymphoma (DLBCL) remains unknown. Herein, we retrospectively analyzed 215 de novo DLBCL patients. According to ISS, there were 90 of 215 (41.9%) patients in stage I, 98 of 215 (45.6%) in stage II and 27 of 215 (12.6%) in stage III group. Patients with ISS stage II/III showed shorter overall survival (OS) and event free survival (EFS) than those with stage I treated with R-CHOP (p = 0.012 and p = 0.043, respectively), but not those treated with CHOP regimen (p > 0.05). Multivariable analysis revealed that ISS, independent of IPI, indicated different survival in both OS (HR, 5.690; 95% CI, 1.270-25.495, p = 0.023) and EFS (HR, 2.116; 95% CI, 1.005-4.455, p = 0.049) in DLBCL patients treated with R-CHOP. ISS could identify patients with better outcome in intermediate-high/high IPI risk patients (p IPI risk patients, which may help to avoid intensive therapy.

  4. Renal transplantation in systemic lupus erythematosus: Comparison of graft survival with other causes of end-stage renal disease.

    Science.gov (United States)

    Horta-Baas, Gabriel; Camargo-Coronel, Adolfo; Miranda-Hernández, Dafhne Guadalupe; Gónzalez-Parra, Leslie Gabriela; Romero-Figueroa, María Del Socorro; Pérez-Cristóbal, Mario

    2017-08-14

    End-stage renal disease (ESRD) due to lupus nephritis (LN) occurs in 10%-30% of patients. Initially systemic lupus erythematosus (SLE) was a contraindication for kidney transplantation (KT). Today, long-term graft survival remains controversial. Our objective was to compare the survival after KT in patients with SLE or other causes of ESRD. All SLE patients who had undergone KT in a retrospective cohort were included. Renal graft survival was compared with that of 50 controls, matched for age, sex, and year of transplantation. Survival was evaluated by the Kaplan-Meier test and the Cox proportional hazards model. Twenty-five subjects with SLE were included. The estimated 1-year, 2- and 5-year survival rates for patients with SLE were 92%, 66% and 66%. Renal graft survival did not differ between patients with SLE and other causes of ESRD (P=.39). The multivariate analysis showed no significant difference in graft survival between the two groups (hazard ratio, HR=1.95, 95% confidence interval [CI] 0.57-6.61, P=.28). The recurrence rate of LN was 8% and was not associated with graft loss. Acute rejection was the only variable associated with graft loss in patients with SLE (HR=16.5, 95% CI 1.94-140.1, P=.01). Renal graft survival in SLE patients did not differ from that reported for other causes of ESRD. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

  5. Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle.

    Science.gov (United States)

    Nishitsuji, Hironori; Yamamoto, Hiromi; Shiina, Ritsuko; Harada, Keisuke; Ujino, Saneyuki; Shimotohno, Kunitada

    2017-02-01

    Currently, it is possible to construct recombinant forms of various viruses, such as human immunodeficiency virus 1 (HIV-1) and hepatitis C virus (HCV), that carry foreign genes such as a reporter or marker protein in their genomes. These recombinant viruses usually faithfully mimic the life cycle of the original virus in infected cells and exhibit the same host range dependence. The development of a recombinant virus enables the efficient screening of inhibitors and the identification of specific host factors. However, to date the construction of recombinant hepatitis B virus (HBV) has been difficult because of various experimental limitations. The main limitation is the compact genome size of HBV, and a fairly strict genome size that does not exceed 1.3 genome sizes, that must be packaged into virions. Thus, the size of a foreign gene to be inserted should be smaller than 0.4 kb if no deletion of the genome DNA is to be performed. Therefore, to overcome this size limitation, the deletion of some HBV DNA is required. Here, we report the construction of recombinant HBV encoding a reporter gene to monitor the early stage of the HBV replication cycle by replacing part of the HBV core-coding region with the reporter gene by deleting part of the HBV pol coding region. Detection of recombinant HBV infection, monitored by the reporter activity, was highly sensitive and less expensive than detection using the currently available conventional methods to evaluate HBV infection. This system will be useful for a number of applications including high-throughput screening for the identification of anti-HBV inhibitors, host factors and virus-susceptible cells.

  6. Risk of end-stage renal disease in systemic lupus erythematosus patients: a nationwide population-based study.

    Science.gov (United States)

    Yu, Kuang-Hui; Kuo, Chang-Fu; Chou, I-Jun; Chiou, Meng-Jiun; See, Lai-Chu

    2016-11-01

    The aim of this study was to estimate the risk of end-stage renal disease (ESRD) in systemic lupus erythematosus (SLE) patients. A cohort with SLE and non-SLE groups from Taiwan's longitudinal Health Insurance Database year 2000 (LHID2000) was developed. The SLE group was made up of those who were newly diagnosed with SLE in 2000. The non-SLE group with other medical illnesses was made up of those who did not have SLE from 1996 until 2008 and that were also matched 1 : 1 with the SLE group by sex, age and initial diagnosis date (index date); 1196 (1058 women and 138 men) individuals in the SLE group were included in this study. Between 2000 and 2008, 61 (2.55%) individuals (SLE, n = 58 [4.85%]; non-SLE, n = 3 [0.25%]) had incident ESRD requiring renal replacement therapy. The incidence rates of ESRD were 612.8 and 29.3 cases per 100 000 patient-years in the SLE and non-SLE groups, respectively. The incidence of ESRD requiring renal replacement therapy occurred more frequently in male SLE (1157.0; 95% CI 502.4-1811.6) than female SLE cases (545.8; 95% CI 388.1-703.5) per 100 000 person-years (P risk of ESRD in SLE patients compared to the general population, but only to those with non-SLE chronic illnesses. © 2016 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.

  7. Fate of pathogen indicators in a domestic blend of food waste and wastewater through a two-stage anaerobic digestion system.

    Science.gov (United States)

    Rounsefell, B D; O'Sullivan, C A; Chinivasagam, N; Batstone, D; Clarke, W P

    2013-01-01

    Anaerobic digestion is a viable on-site treatment technology for rich organic waste streams such as food waste and blackwater. In contrast to large-scale municipal wastewater treatment plants which are typically located away from the community, the effluent from any type of on-site system is a potential pathogenic hazard because of the intimacy of the system to the community. The native concentrations of the pathogen indicators Escherichia coli, Clostridium perfringens and somatic coliphage were tracked for 30 days under stable operation (organic loading rate (OLR) = 1.8 kgCOD m(-3) day(-1), methane yield = 52% on a chemical oxygen demand (COD) basis) of a two-stage laboratory-scale digester treating a mixture of food waste and blackwater. E. coli numbers were reduced by a factor of 10(6.4) in the thermophilic stage, from 10(7.5±0.3) to 10(1.1±0.1) cfu 100 mL(-1), but regenerated by a factor of 10(4) in the mesophilic stage. Neither the thermophilic nor mesophilic stages had any significant impact on C. perfringens concentrations. Coliphage concentrations were reduced by a factor of 10(1.4) across the two stages. The study shows that anaerobic digestion only reduces pathogen counts marginally but that counts in effluent samples could be readily reduced to below detection limits by filtration through a 0.22 µm membrane, to investigate membrane filtration as a possible sanitation technique.

  8. The central nervous system of the fetus in pregnant women after organ-preserving treatment of precancer and early stages of cervical cancer

    International Nuclear Information System (INIS)

    Egorov, O.O.

    2015-01-01

    Magnetic resonance imaging is a promising method of research in tocology. The use of MRI for the first time with high precision anatomical interpretation to diagnose the state of the Central nervous system of the fetus in pregnant women after organ-preserving treatment of precancerous cervical disease and early stages of cervical cancer

  9. A 5-year prospective multicenter study on 1-stage smooth-surface Branemark System implants with early loading in edentulous mandibles

    NARCIS (Netherlands)

    Friberg, Bertil; Raghoebar, Gerry M.; Grunert, Ingrid; Hobkirk, John A.; Tepper, Gabor

    2008-01-01

    Purpose: The purpose of the current prospective multicenter Study was to evaluate the 5-year implant success and peri-implant conditions of smooth-surface Branemark System implants when using a novel technique including a 1-stage surgical procedure with early loading in edentulous mandibles.

  10. Low Voltage Ride-Through of Two-Stage Grid-Connected Photovoltaic Systems Through the Inherent Linear Power-Voltage Characteristic

    DEFF Research Database (Denmark)

    Yang, Yongheng; Sangwongwanich, Ariya; Liu, Hongpeng

    2017-01-01

    In this paper, a cost-effective control scheme for two-stage grid-connected PhotoVoltaic (PV) systems in Low Voltage Ride-Through (LVRT) operation is proposed. In the case of LVRT, the active power injection by PV panels should be limited to prevent from inverter over-current and also energy...

  11. The development of giftedness within the three-level system of music education in Poland and Serbia: Outcomes at different stages

    Directory of Open Access Journals (Sweden)

    Nogaj Anna Antonina

    2015-01-01

    Full Text Available The character of this article is theoretical and practice oriented, therefore offering educational implications for music educators and music psychologists. Its main objective is to give an overview of the most important musical and developmental changes of musically talented children and youth, at different stages of the three-level specialized music education. The theoretical background of the article refers to stage theories of development of gifted with the intention to point out correspondence between stages of development and the specificity of music education stages. Theoretical conceptions are used as a framework to synthesize and to interpret empirical data and practice-related professional experiences of psychologists in music schools in Poland and Serbia. Both countries, though culturally distinct in nature and in the character of traditional music, are characterized by a very similar system of specialized/professional music education. Further on, the article presents a review of the wide range of benefits/outcomes experienced by music school students, as a result of the highly simulative, systematic and supportive environment of music learning. The article begins with an introduction to the context of the specialized music education system in Poland and Serbia and then presents how a particular system of education for the gifted contributes to the development in the field of acquiring musical knowledge and skills, as well as to benefits/outcomes of the education system for the personal, social and professional development of the musically gifted, indicating a wide range of positive experiences.

  12. Thermal modelling of the multi-stage heating system with variable boundary conditions in the wafer based precision glass moulding process

    DEFF Research Database (Denmark)

    Sarhadi, Ali; Hattel, Jesper Henri; Hansen, Hans Nørgaard

    2012-01-01

    pressures. Finally, the three-dimensional modelling of the multi-stage heating system in the wafer based glass moulding process is simulated with the FEM software ABAQUS for a particular industrial application for mobile phone camera lenses to obtain the temperature distribution in the glass wafer...

  13. Laboratory evaluation of a two-stage treatment system for TCE cometabolism by a methane-oxidizing mixed culture.

    Science.gov (United States)

    Smith, L H; McCarty, P L

    1997-08-20

    The objective of this research was to evaluate several factors affecting the performance of a two-stage treatment system employing methane-oxidizing bacteria for trichloroethylene (TCE) biodegradation. The system consists of a completely mixed growth reactor and a plug-flow transformation reactor in which the TCE is cometabolized. Laboratory studies were conducted with continuous growth reactors and batch experiments simulating transformation reactor conditions. Performance was characterized in terms of TCE transformation capacity (T(C), g TCE/g cells), transformation yield (T(Y), g TCE/g CH(4)), and the rate coefficient ratio k(TCE)/K(S,TCE) (L/mg-d). The growth reactor variables studied were solids retention time (SRT) and nutrient nitrogen (N) concentration. Formate and methane were evaluated as potential transformation reactor amendments. Comparison of cultures from 2- and 8-day SRT (nitrogen-limited) growth reactors indicated that there was no significant effect of growth reactor SRT or nitrogen availability on T(C) or T(Y), but N-limited conditions yielded higher k(TCE)/K(S,TCE). The TCE cometabolic activity of the 8-day SRT, N-limited growth reactor culture varied significantly during a 7-year period of operation. The T(C) and T(Y) of the resting cells increased gradually to levels a factor of 2 higher than the initial values. The reasons for this increase are unknown. Formate addition to the transformation reactor gave higher T(C) and T(Y) for 2-day SRT growth reactor conditions and significantly lower T(C), T(Y), and k(TCE)/K(S,TCE) for 8-day SRT N-limited conditions. Methane addition to the transformation reactor inhibited TCE cometabolism at low TCE concentrations and enhanced TCE cometabolism at high TCE concentrations, indicating that the TCE cometabolism in the presence of methane does not follow simple competitive inhibition kinetics. (c) 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 55: 650-659, 1997.

  14. External validation of the endometriosis fertility index (EFI) staging system for predicting non-ART pregnancy after endometriosis surgery.

    Science.gov (United States)

    Tomassetti, C; Geysenbergh, B; Meuleman, C; Timmerman, D; Fieuws, S; D'Hooghe, T

    2013-05-01

    Can the ability of the endometriosis fertility index (EFI) to predict non-assisted reproductive technology (ART) pregnancy after endometriosis surgery be confirmed by an external validation study? The significant relationship between the EFI score and the time to non-ART pregnancy observed in our study represents an external validation of this scoring system. The EFI was previously developed and tested prospectively in a single center, but up to now no external validation has been published. Our data provide validation of the EFI in an external fertility unit on a robust scientific basis, to identify couples with a good prognosis for spontaneous conception who can therefore defer ART treatment, regardless of their revised American Fertility Society (rAFS) endometriosis staging. Retrospective cohort study where the EFI was calculated based on history and detailed surgical findings, and related to pregnancy outcome in 233 women attempting non-ART conception immediately after surgery; all data used for EFI calculation and analysis of reproductive outcome had been collected prospectively as part of another study. The EFI score was calculated (score 0-10) for 233 women with all rAFS endometriosis stages (minimal-mild, n = 75; moderate-severe, n = 158) after endometriosis surgery (1 September 2006-30 September 2010) in a university hospital-based reproductive medicine unit with combined expertise in reproductive surgery and medically assisted reproduction. All participants attempted non-ART conception immediately after surgery by natural intercourse, ovulation induction with timed intercourse or intrauterine insemination (with or without ovulation induction or controlled ovarian stimulation). All analyses were performed for three different definitions of pregnancy [overall (any HCG >25 IU/l), clinical and ongoing >20 weeks]. Six groups were distinguished (EFI scores 1-3, 4, 5, 6, 7+8, 9+10), and Kaplan-Meier (K-M) estimates for cumulative pregnancy rate were calculated

  15. Footprints of phineas gage: Historical beginnings on the origins of brain and behavior and the birth of cerebral localizationism

    Directory of Open Access Journals (Sweden)

    Bhaskara P Shelley

    2016-01-01

    Full Text Available The intellectual revolution led by ancient Greek philosophers and physicians witnessed the extraordinary evolution of the birth of neuroscience from speculations of cardiocentrism (Aristotelism and encephalocentrism (Galenism. Later further development of neurosciences was hallmarked by the development of anatomic theories of phrenology by the German physician Franz Joseph Gall in 1796. Although phrenology was a pseudoscience, it was Gall who laid the foundations for the subsequent biologically based doctrine of brain behavior localization. The amazing story of Phineas Gage is a classic case in the nineteenth-century neurosciences literature that played a pivotal role in the concept of cerebral localizationism, a theory that moved beyond phrenology. This iconic case marked the historical beginnings of brain origins of human behavior and elucidated a link between brain trauma, prefrontal brain damage and personality change.

  16. Influence of the Testing Gage Length on the Strength, Young's Modulus and Weibull Modulus of Carbon Fibres and Glass Fibres

    Directory of Open Access Journals (Sweden)

    Luiz Claudio Pardini

    2002-10-01

    Full Text Available Carbon fibres and glass fibres are reinforcements for advanced composites and the fiber strength is the most influential factor on the strength of the composites. They are essentially brittle and fail with very little reduction in cross section. Composites made with these fibres are characterized by a high strength/density ratio and their properties are intrisically related to their microstructure, i.e., amount and orientation of the fibres, surface treatment, among other factors. Processing parameters have an important role in the fibre mechanical behaviour (strength and modulus. Cracks, voids and impurities in the case of glass fibres and fibrillar misalignments in the case of carbon fibres are created during processing. Such inhomogeneities give rise to an appreciable scatter in properties. The most used statistical tool that deals with this characteristic variability in properties is the Weibull distribution. The present work investigates the influence of the testing gage length on the strength, Young's modulus and Weibull modulus of carbon fibres and glass fibres. The Young's modulus is calculated by two methods: (i ASTM D 3379M, and (ii interaction between testing equipment/specimen The first method resulted in a Young modulus of 183 GPa for carbon fibre, and 76 GPa for glass fibre. The second method gave a Young modulus of 250 GPa for carbon fibre and 50 GPa for glass fibre. These differences revelead differences on how the interaction specimen/testing machine can interfere in the Young modulus calculations. Weibull modulus can be a tool to evaluate the fibre's homogeneity in terms of properties and it is a good quality control parameter during processing. In the range of specimen gage length tested the Weibull modulus for carbon fibre is ~ 3.30 and for glass fibres is ~ 5.65, which indicates that for the batch of fibres tested, the glass fibre is more uniform in properties.

  17. Staging Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    In recent years, the social sciences have taken a “mobilities turn.” There has been a developing realisation that mobilities do not “just happen.” Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed and li......, the book asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities?...... that mobility is more than movement between point A and B. It explores how the movement of people, goods, information, and signs influences human understandings of self, other and the built environment. Moving towards a new understanding of the relationship between movement, interaction and environments...

  18. Evaluation of the TSI aerosol impactor 3306/3321 system using a redesigned impactor stage with solution and suspension metered-dose inhalers.

    Science.gov (United States)

    Harris, Julie A; Stein, Stephen W; Myrdal, Paul B

    2006-03-10

    The purpose of this research was to evaluate a redesigned impactor stage for the TSI Model 3306 Impactor Inlet with nozzles adjusted to obtain a target cut-point of 4.7 microm. It has been determined that the previous cut-point used in the Model 3306 was nominally closer to 4.14 microm, thus potentially impacting the characterization of aerosol mass. The reassessment of the Model 3306 was performed on 4 solution and 2 suspension metered-dose inhaler (MDI) formulations. The redesigned impactor stage resulted in a 5% to 6% increase in aerosol mass when compared with the previous impactor stage for the products Ventolin-HFA, Proventil-HFA, and 2 cyclosporin solution formulations with high ethanol concentrations (15% wt/wt). For the formulations with low ethanol concentrations (3% wt/wt), minimal differences were observed between the 2 cut-points. In addition, this study reevaluated the requirement of a vertical inlet extension length when using the TSI 3306/3321 system with the redesigned cut-point. It was shown that the use of a 20-cm extension provides mass and aerosol size distributions that are comparable to the Andersen 8-stage Cascade Impactor, for both solution and suspension MDIs. This work indicates that the TSI 3306/3321 system is suitable for preformulation studies of both suspension and solution MDI systems.

  19. Investigation on the removal of H2S from microwave pyrolysis of sewage sludge by an integrated two-stage system.

    Science.gov (United States)

    Zhang, Jun; Tian, Yu; Yin, Linlin; Zuo, Wei; Gong, Zhenlong; Zhang, Jie

    2017-08-01

    In this study, an integrated two-stage system, including the in-situ catalytic microwave pyrolysis (ICMP) and subsequent catalytic wet oxidation (CWO) processes, was proposed to remove H 2 S released from microwave-induced pyrolysis of sewage sludge. The emission profile and H 2 S removal from the pyrolysis of raw sewage sludge (SS) and sewage sludge spiked with conditioner CaO (SS-CaO) were investigated. The results showed that CaO played a positive role on sulfur fixation during the pyrolysis process. It was found that SS-CaO (10 wt.%) contributed to about 35% of H 2 S removal at the first stage (ICMP process). Additionally, the CWO process was demonstrated to have promising potential for posttreatment of remaining H 2 S gas. At the Fe 3+ concentration of 30 g/L, the maximum H 2 S removal efficiency of 94.8% was obtained for a single Fe 3+ /Cu 2+ solution. Finally, at the pyrolysis temperature of 800 °C, 99.7% of H 2 S was eliminated by the integrated two-stage system meeting the discharge standard of China. Therefore, the integrated two-stage system of ICMP + CWO may provide a promising strategy to remove H 2 S dramatically for the biomass pyrolysis industry.

  20. Guidelines for using sensitivity analysis and auto-calibration tools for multi-gage or multi-step calibration in SWAT

    Science.gov (United States)

    Autocalibration of a water quality model such as SWAT (Soil and Water Assessment Tool) can be a powerful, labor-saving tool. When multi-gage or multi-pollutant calibration is desired, autocalibration is essential because the time involved in manual calibration becomes prohibitive. The ArcSWAT Interf...