WorldWideScience

Sample records for stabilization technology combinations

  1. Effects of different combinations of nanocrystallization technologies on avanafil nanoparticles: in vitro, in vivo and stability evaluation.

    Science.gov (United States)

    Soliman, Kareem AbuBakr; Ibrahim, Howida Kamal; Ghorab, Mahmoud Mohammed

    2017-01-30

    The study investigated the effects of different combined top-down and bottom-up nanocrystallization technologies on particle size and solid state of avanafil nanoparticles. Combined antisolvent precipitation-ultrasonication (sonoprecipitation) technique was adopted to prepare 18 formulas according to 3 2 .2 1 factorial design using 3 stabilizers; Tween 80, polyvinyl alcohol (PVA) and Pluronic F68 at different concentrations with different cryoprotectants. Particle size analysis of the lyophilized formulas showed that Tween 80 was an effective nanoparticles stabilizer in contrast to Pluronic F68 and PVA which failed to prevent nanoparticles flocculation when they were used at high concentration. The combined effects of nanonization and amorphism contributed to the improvement in solubility. Further processing of the sonoprecipitated formulas by high pressure homogenization (HPH) (modified NANOEDGE™ technology) resulted in further size reduction of PVA-stabilized particles, while it stimulated flocculation of Tween-stabilized nanoparticles. Nevertheless, all of the homogenized formulas partially retrieved their crystallinity which reduced their solubility. Non-homogenized formula 2E composed of 1:2 (avanafil: Tween) with glucose as cryoprotectant, exhibited 13.68- and 2.59-fold improvement in solubility and in vitro dissolution, respectively. This formula had oral bioavailability of 137.02% relative to Spedra ® tablets and it maintained its nanosize, amorphism and dissolution behavior over 6 months of storage under stress conditions. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. IMPROVED ROOF STABILIZATION TECHNOLOGIES

    International Nuclear Information System (INIS)

    Ebadian, M.A.

    1999-01-01

    Many U.S. Department of Energy (DOE) remediation sites have performed roof repair and roof replacement to stabilize facilities prior to performing deactivation and decommissioning (D and D) activities. This project will review the decision criteria used by these DOE sites, along with the type of repair system used for each different roof type. Based on this information, along with that compiled from roofing experts, a decision-making tool will be generated to aid in selecting the proper roof repair systems. Where appropriate, innovative technologies will be reviewed and applied to the decision-making tool to determine their applicability. Based on the results, applied research and development will be conducted to develop a method to repair these existing roofing systems, while providing protection for the D and D worker in a cost-efficient manner

  3. IMPROVED ROOF STABILIZATION TECHNOLOGIES

    Energy Technology Data Exchange (ETDEWEB)

    M.A. Ebadian, Ph.D.

    1999-01-01

    Many U.S. Department of Energy (DOE) remediation sites have performed roof repair and roof replacement to stabilize facilities prior to performing deactivation and decommissioning (D&D) activities. This project will review the decision criteria used by these DOE sites, along with the type of repair system used for each different roof type. Based on this information, along with that compiled from roofing experts, a decision-making tool will be generated to aid in selecting the proper roof repair systems. Where appropriate, innovative technologies will be reviewed and applied to the decision-making tool to determine their applicability. Based on the results, applied research and development will be conducted to develop a method to repair these existing roofing systems, while providing protection for the D and D worker in a cost-efficient manner.

  4. Improved roof stabilization technologies

    International Nuclear Information System (INIS)

    Ebadian, M.A.

    1998-01-01

    Decontamination and decommissioning (D and D) activities require that personnel have access to all areas of structures, some of which are more than 40 years old. In many cases, these structures have remained in a standby condition for up to 10 years; few preventative maintenance activities have been performed on them because of lack of funding or a defined future plan of action. This situation has led to deteriorated building conditions, resulting in potential personnel safety hazards. In addition, leaky roofs allow water to enter the buildings, which can cause the spread of contamination and increase building deterioration, worsening the already unsafe working conditions. To ensure worker safety and facilitate building dismantlement, the assessment of roof stabilization techniques applicable to US Department of Energy (DOE) structures has become an important issue. During Fiscal year 1997 (FY97), a comprehensive reliability-based model for the structural stabilization analysis of roof system in complex structures was developed. The model consists of three major components: a material testing method, a deterministic structural computer model, and a reliability-based optimization, and probabilistic analyses of roof structures can be implemented. Given site-specific needs, this model recommends the most appropriate roof stabilization system. This model will give not only an accurate evaluation of the existing roof system in complex structures, but it will also be a reliable method to aid the decision-making process. This final report includes in its appendix a Users' Manual for the Program of Deterministic and Reliability Analysis of Roof Structures

  5. Soil treatment technologies combined

    International Nuclear Information System (INIS)

    Davis, K.J.; Russell, D.J.

    1993-01-01

    The Superfund Amendments and Reauthorization Act (SARA) presents a legislative mandate to select effective and long-term remediation options. SARA has spurred the development of innovative technologies and other remedial alternatives that can be applied to the diverse contaminated media at hazardous waste sites. Even though many treatment technologies have been investigated for use at hazardous waste sites, only a few have been used successfully. Soil vapor extraction and soil composting have achieved cleanup goals at sites with soils contaminated with solvents, aromatic hydrocarbons and petroleum derivatives. With the increased use of innovative on-site technologies, the integration of multiple technologies to remediate sites with complex contaminants becomes a viable and cost-effective remedial alternative. Soil vapor extraction and composting have been applied successfully as individual technologies at hazardous waste sites. An integration of these two technologies also has been used to remediate a complex contaminated site

  6. Combining people, processes, and technology.

    Science.gov (United States)

    Fishman, Julia

    2017-06-01

    Julia Fishman, managing director and vice-President, Clinical Strategy, at TeleTracking Technologies, discusses the in-use benefits of patient, staff, and asset tracking and flow technologies, arguing that their effective deployment across an NHS under considerable pressure on many fronts can free up more time to care, bring considerable cost and wider efficiencies, and help to address the perennial issue of 'bed blocking'.

  7. Landfill stabilization focus area: Technology summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    Landfills within the DOE Complex as of 1990 are estimated to contain 3 million cubic meters of buried waste. The DOE facilities where the waste is predominantly located are at Hanford, the Savannah River Site (SRS), the Idaho National Engineering Laboratory (INEL), the Los Alamos National Laboratory (LANL), the Oak Ridge Reservation (ORR), the Nevada Test Site (NTS), and the Rocky Flats Plant (RFP). Landfills include buried waste, whether on pads or in trenches, sumps, ponds, pits, cribs, heaps and piles, auger holes, caissons, and sanitary landfills. Approximately half of all DOE buried waste was disposed of before 1970. Disposal regulations at that time permitted the commingling of various types of waste (i.e., transuranic, low-level radioactive, hazardous). As a result, much of the buried waste throughout the DOE Complex is presently believed to be contaminated with both hazardous and radioactive materials. DOE buried waste typically includes transuranic-contaminated radioactive waste (TRU), low-level radioactive waste (LLW), hazardous waste per 40 CFR 26 1, greater-than-class-C waste per CFR 61 55 (GTCC), mixed TRU waste, and mixed LLW. The mission of the Landfill Stabilization Focus Area is to develop, demonstrate, and deliver safer,more cost-effective and efficient technologies which satisfy DOE site needs for the remediation and management of landfills. The LSFA is structured into five technology areas to meet the landfill remediation and management needs across the DOE complex. These technology areas are: assessment, retrieval, treatment, containment, and stabilization. Technical tasks in each of these areas are reviewed.

  8. Landfill stabilization focus area: Technology summary

    International Nuclear Information System (INIS)

    1995-06-01

    Landfills within the DOE Complex as of 1990 are estimated to contain 3 million cubic meters of buried waste. The DOE facilities where the waste is predominantly located are at Hanford, the Savannah River Site (SRS), the Idaho National Engineering Laboratory (INEL), the Los Alamos National Laboratory (LANL), the Oak Ridge Reservation (ORR), the Nevada Test Site (NTS), and the Rocky Flats Plant (RFP). Landfills include buried waste, whether on pads or in trenches, sumps, ponds, pits, cribs, heaps and piles, auger holes, caissons, and sanitary landfills. Approximately half of all DOE buried waste was disposed of before 1970. Disposal regulations at that time permitted the commingling of various types of waste (i.e., transuranic, low-level radioactive, hazardous). As a result, much of the buried waste throughout the DOE Complex is presently believed to be contaminated with both hazardous and radioactive materials. DOE buried waste typically includes transuranic-contaminated radioactive waste (TRU), low-level radioactive waste (LLW), hazardous waste per 40 CFR 26 1, greater-than-class-C waste per CFR 61 55 (GTCC), mixed TRU waste, and mixed LLW. The mission of the Landfill Stabilization Focus Area is to develop, demonstrate, and deliver safer,more cost-effective and efficient technologies which satisfy DOE site needs for the remediation and management of landfills. The LSFA is structured into five technology areas to meet the landfill remediation and management needs across the DOE complex. These technology areas are: assessment, retrieval, treatment, containment, and stabilization. Technical tasks in each of these areas are reviewed

  9. Ultimate Opening Combined with Area Stability Applied to Urban Scenes

    OpenAIRE

    Marcotegui , Beatriz; Serna , Andrés; Hernández , Jorge

    2017-01-01

    International audience; This paper explores the use of ultimate opening in urban analysis context. It demonstrates the efficiency of this approach for street level elevation images, derived from 3D point clouds acquired by terrestrial mobile mapping systems. An area-stability term is introduced in the residual definition, reducing the over-segmentation of the vegetation while preserving small significant regions. We compare two possible combinations of the Ultimate Opening and the Area Stabil...

  10. Combining nonthermal technologies to control foodborne microorganisms.

    Science.gov (United States)

    Ross, Alexander I V; Griffiths, Mansel W; Mittal, Gauri S; Deeth, Hilton C

    2003-12-31

    Novel nonthermal processes, such as high hydrostatic pressure (HHP), pulsed electric fields (PEFs), ionizing radiation and ultrasonication, are able to inactivate microorganisms at ambient or sublethal temperatures. Many of these processes require very high treatment intensities, however, to achieve adequate microbial destruction in low-acid foods. Combining nonthermal processes with conventional preservation methods enhances their antimicrobial effect so that lower process intensities can be used. Combining two or more nonthermal processes can also enhance microbial inactivation and allow the use of lower individual treatment intensities. For conventional preservation treatments, optimal microbial control is achieved through the hurdle concept, with synergistic effects resulting from different components of the microbial cell being targeted simultaneously. The mechanisms of inactivation by nonthermal processes are still unclear; thus, the bases of synergistic combinations remain speculative. This paper reviews literature on the antimicrobial efficiencies of nonthermal processes combined with conventional and novel nonthermal technologies. Where possible, the proposed mechanisms of synergy is mentioned.

  11. SILICATE TECHNOLOGY CORPORATION'S SOLIDIFICATION/ STABILIZATION TECHNOLOGY FOR ORGANIC AND INORGANIC CONTAMINANTS IN SOILS - APPLICATIONS ANALYSIS REPORT

    Science.gov (United States)

    This Applications Analysis Report evaluates the solidification/stabilization treatment process of Silicate Technology Corporation (STC) for the on-site treatment of hazardous waste. The STC immobilization technology utilizes a proprietary product (FMS Silicate) to chemically stab...

  12. Containment and stabilization technologies for mixed hazardous and radioactive wastes

    International Nuclear Information System (INIS)

    Buelt, J.L.

    1993-05-01

    A prevalent approach to the cleanup of waste sites contaminated with hazardous chemicals and radionuclides is to contain and/or stabilize wastes within the site. Stabilization involves treating the wastes in some fashion, either in situ or above ground after retrieval, to reduce the leachability and release rate of waste constituents to the environment. This approach is generally reserved for radionuclide contaminants, inorganic hazardous contaminants such as heavy metals, and nonvolatile organic contaminants. This paper describes the recent developments in the technical options available for containing and stabilizing wastes. A brief description of each technology is given along with a discussion of the most recent developments and examples of useful applications

  13. Reactor surface contamination stabilization. Innovative technology summary report

    International Nuclear Information System (INIS)

    1998-11-01

    Contaminated surfaces, such as the face of a nuclear reactor, need to be stabilized (fixed) to avoid airborne contamination during decontamination and decommissioning activities, and to prepare for interim safe storage. The traditional (baseline) method of fixing the contamination has been to spray a coating on the surfaces, but ensuring complete coverage over complex shapes, such as nozzles and hoses, is difficult. The Hanford Site C Reactor Technology Demonstration Group demonstrated innovative technologies to assess stabilization properties of various coatings and to achieve complete coverage of complex surfaces on the reactor face. This demonstration was conducted in two phases: the first phase consisted of a series of laboratory assessments of various stabilization coatings on metal coupons. For the second phase, coatings that passed the laboratory tests were applied to the front face of the C Reactor and evaluated. The baseline coating (Rust-Oleum No. 769) and one of the innovative technologies did not completely cover nozzle assemblies on the reactor face, the most critical of the second-phase evaluation criteria. However, one of the innovative coating systems, consisting of a base layer of foam covered by an outer layer of a polymeric film, was successful. The baseline technology would cost approximately 33% as much as the innovative technology cost of $64,000 to stabilize an entire reactor face (196 m 2 or 2116 ft 2 ) with 2,004 nozzle assemblies, but the baseline system failed to provide complete surface coverage

  14. Insulin delivery systems combined with microneedle technology.

    Science.gov (United States)

    Jin, Xuan; Zhu, Dan Dan; Chen, Bo Zhi; Ashfaq, Mohammad; Guo, Xin Dong

    2018-03-29

    Diabetes, a metabolic disorder of glucose, is a serious chronic disease and an important public health problem. Insulin is one of the hormones for modulating blood glucose level and the products of which is indispensable for most diabetes patients. Introducing microneedles (MNs) to insulin delivery is promising to pave the way for modulating glucose level noninvasively of diabetes patients, as which born to be painless, easy to handle and no need of any power supply. In this work, we review the process of insulin delivery systems (IDSs) based on MN technology in terms of two categories: drug free MNs and drug loaded MNs. Drug free MNs include solid MNs ("poke and patch"), hollow MNs ("poke and flow") and reservoir-based swelling MNs ("poke and swell R-type"), and drug loaded MNs include coated MNs ("coat and poke"), dissolving MNs ("poke and release") and insulin incorporated swelling MNs ("poke and swell I-type"). Majority researches of MN-based IDSs have been conducted by using hollow MNs or dissolving MNs, and almost all clinical trials for MN-based IDSs have employed hollow MNs. "Poke and patch" approach dramatically increase skin permeability compared to traditional transdermal patch, but MNs fabricated from silicon or metal may leave sharp waste in the skin and cause a safety issue. "Poke and flow" approach, similar to transitional subcutaneous (SC) injection, is capable of producing faster insulin absorption and action than SC injection but may associate with blockage, leakage and low flow rate. Coated MNs are able of retaining the activity of drug, which loaded in a solid phase, for a long time, however have been relatively less studied for insulin application as the low drug dosing. "Poke and release" approach leaves no biohazardous sharp medical waste and is capable of rapid drug release. "Poke and swell R-type" can be seen as a combination of "poke and flow" and "poke and patch" approach, while "poke and swell I-type" is an approach between "coat and

  15. INERTIAL TECHNOLOGIES IN SYSTEMS FOR STABILIZATION OF GROUND VEHICLES EQUIPMENT

    Directory of Open Access Journals (Sweden)

    Olha Sushchenko

    2016-12-01

    Full Text Available Purpose: The vibratory inertial technology is a recent modern inertial technology. It represents the most perspective approach to design of inertial sensors, which can be used in stabilization and tracking systems operated on vehicles of the wide class. The purpose of the research is to consider advantages of this technology in comparison with laser and fiber-optic ones. Operation of the inertial sensors on the ground vehicles requires some improvement of the Coriolis vibratory gyroscope with the goal to simplify information processing, increase reliability, and compensate bias. Methods: Improvement of the Coriolis vibratory gyroscope includes introducing of the phase detector and additional excitation unit. The possibility to use the improved Coriolis vibratory gyroscope in the stabilization systems operated on the ground vehicles is shown by means of analysis of gyroscope output signal. To prove efficiency of the Coriolis vibratory gyroscope in stabilization system the simulation technique is used. Results: The scheme of the improved Coriolis vibratory gyroscope including the phase detector and additional excitation unit is developed and analyzed. The way to compensate bias is determined. Simulation of the stabilization system with the improved Coriolis vibratory gyroscope is carried out. Expressions for the output signals of the improved Coriolis vibratory gyroscope are derived. The error of the output signal is estimated and the possibility to use the modified Coriolis vibratory gyroscope in stabilization systems is proved. The results of stabilization system simulation are given. Their analysis is carried out. Conclusions: The represented results prove efficiency of the proposed technical decisions. They can be useful for design of stabilization platform with instrumental equipment operated on moving vehicles of the wide class.

  16. Effects of antioxidant combinations on shelf stability of irradiated chicken sausage during storage

    International Nuclear Information System (INIS)

    Hwang, Ko-Eun; Kim, Hyun-Wook; Song, Dong-Heon; Kim, Yong-Jae; Ham, Yun-Kyung; Lee, Ju-Woon; Choi, Yun-Sang; Kim, Cheon-Jei

    2015-01-01

    This study was conducted in order to investigate the combined effects of gamma irradiation (0, 2.5, and 5 kGy) and antioxidant combination, mugwort extract (ME) and ascorbic acid (Aa), on the pH, total color difference (ΔE), hue angle (H°), 2-thiobarbituricacid-reactive substances (TBARS) values, residual nitrite contents, and sensory evaluation in chicken sausage during storage. The pH values and sensory properties, except for color, of chicken sausage were not significantly affected by adding ME or treating irradiation during storage. However, ΔE, and H° values of samples containing ME (either alone or with Aa) were higher than that of control, whereas irradiation had no significant effect during storage. A combination of ME+Aa (0.2% ME+0.05% Aa) was effective at delaying lipid oxidation in irradiated chicken sausage. In addition, nitrite contents were reduced by gamma ray as a dose dependent manner and, particularly in ME+Aa was most effective in decreasing the residual nitrite. Our results suggested that gamma irradiation combined with an antioxidant mixture is a useful technology for reducing the residual nitrite and retarding the lipid oxidation in chicken sausage. - Highlights: • We evaluate the combined effects of gamma irradiation and antioxidant combination. • Gamma irradiation is effective in reducing the nitrite levels. • Combination of antioxidants might be helpful in enhancing the oxidative stability

  17. Scientific applications of frequency-stabilized laser technology in space

    Science.gov (United States)

    Schumaker, Bonny L.

    1990-01-01

    A synoptic investigation of the uses of frequency-stabilized lasers for scientific applications in space is presented. It begins by summarizing properties of lasers, characterizing their frequency stability, and describing limitations and techniques to achieve certain levels of frequency stability. Limits to precision set by laser frequency stability for various kinds of measurements are investigated and compared with other sources of error. These other sources include photon-counting statistics, scattered laser light, fluctuations in laser power, and intensity distribution across the beam, propagation effects, mechanical and thermal noise, and radiation pressure. Methods are explored to improve the sensitivity of laser-based interferometric and range-rate measurements. Several specific types of science experiments that rely on highly precise measurements made with lasers are analyzed, and anticipated errors and overall performance are discussed. Qualitative descriptions are given of a number of other possible science applications involving frequency-stabilized lasers and related laser technology in space. These applications will warrant more careful analysis as technology develops.

  18. Combining expedited cleanup with innovative technology demonstrations

    International Nuclear Information System (INIS)

    Hagood, M.C.; Rohay, V.J.; Valcich, P.J.; Brouns, T.M.; Cameron, R.J.

    1993-04-01

    A Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) expedited response action (ERA) has been initiated at the Hanford Site, Washington, for the removal of carbon tetrachloride from contaminated soils to mitigate further contamination of the groundwater. Soil vapor extraction with aboveground collection and treatment was chosen as the preferred remedial technology for the first phase of the ERA. At the same time, innovative technology demonstrations are being conducted in coordination with the ERA to determine the viability of emerging technologies that can be used to characterize, remediate, and monitor carbon tetrachloride and cocontaminants. The overall goal is to improve the performance and decrease the costs of carbon tetrachloride remediation while maintaining a safe working environment

  19. TECHNOLOGY EVALUATION REPORT: SILICATE TECHNOLOGY CORPORATION - SOLIDIFICATION/STABILIZATION OF PCP AND INORGANIC CONTAMINANTS IN SOILS - SELMA, CA

    Science.gov (United States)

    This Technolgy Evaluation Report evaluates the solidification/stabilization process of Silicate Technology Corporation (STC) for the on-site treatment of contaminated soil The STC immobilization technology uses a proprietary product (FMS Silicate) to chemically stabilize and ...

  20. Combining solid biomass combustion and stirling technology

    Energy Technology Data Exchange (ETDEWEB)

    Siemers, W.; Senkel, N. [CUTEC-Institut GmbH, Clausthal-Zellerfeld (Germany)], e-mail: werner.siemers@cutec.de

    2012-11-01

    Decentralised electricity production in combination with and based on biomass still finds some difficulties in real applications. One concept favoured in a recent project is the connection of a wood chip furmace with a Stirling engine. Because the direct exposure of the Stirling head causes numerous problems, the solution is sought in designing an indirect heat transfer system. The main challenge is the temperature level, which should be reached for high electrical efficiencies. Temperatures above 1000 deg C at the biomass combustion side are needed for an efficient heat transfer at some 850 deg C at the Stirling engine in theory. Measurements on both installations have been conducted and analyzed. After this, the design phase is started. However, no final choice on the design has been taken.

  1. Technology for computer-stabilized peak of NaI(Tl) gamma spectrum

    International Nuclear Information System (INIS)

    Chen Jianzhen; Guo Lanying; Ling Qiu; Qu Guopu; Zhao Lihong; Hu Chuangye

    2005-01-01

    An improved technology for spectrum stabilization of NaI(Tl) gamma spectrum was introduced. This technology is based on the system using a reference peak, which is equivalent gamma peak of 241 Am source. The computer seeks peak's position deviation and computes adjust value of programmable amplifier and controls programmable amplifier to stabilize spectrum by digital PID. This is a technology of spectrum stabilizing with 'hardware + reference-peak + software' and has high stability and fast speed of spectrum stabilizing. (author)

  2. The market outlook for integrated gasification combined cycle technology

    International Nuclear Information System (INIS)

    MacGregor, P.R.; Maslak, C.E.; Stoll, H.G.

    1991-01-01

    Integrated gasification combined cycle (IGCC) technology was developed in the 1970s and is now competitive with other coal fired technologies. Because it is a new technology, IGCC technology developments are continuing at a rapid pace and the trend in decreasing capital costs is similar to the same trend seen during the early decades of simple cycle gas turbines. Consequently, IGCC technology is expected to be even more economical during the mid and late 1990s than it is today. The objective of this paper is to provide an examination of the basic economic principles of IGCC technology and to illustrate the extent to which this technology is a viable least-cost generation addition technology. Moreover, key reliability and emissions issues are addressed in relation to the technology alternatives. This paper is organized to first review the IGCC technology and to contrast its reliability, emission, performance and cost data with the three key commercially proven technologies: simple cycle combustion turbines, combined cycle plants, and coal-fired steam plants. Economic screening curves are used to illustrate the need for a balanced generation expansion mix of technologies. The regional market opportunity for coal fueled technology orders in the US from 1992 through 2005 is presented

  3. Research Technology (ASTP) Rocket Based Combined Cycle (RBCC) Engine

    Science.gov (United States)

    2004-01-01

    Pictured is an artist's concept of the Rocket Based Combined Cycle (RBCC) launch. The RBCC's overall objective is to provide a technology test bed to investigate critical technologies associated with opperational usage of these engines. The program will focus on near term technologies that can be leveraged to ultimately serve as the near term basis for Two Stage to Orbit (TSTO) air breathing propulsions systems and ultimately a Single Stage To Orbit (SSTO) air breathing propulsion system.

  4. Application of a combined superconducting fault current limiter and STATCOM to enhancement of power system transient stability

    Energy Technology Data Exchange (ETDEWEB)

    Mahdad, Belkacem, E-mail: bemahdad@mselab.org; Srairi, K.

    2013-12-15

    Highlights: •A simple interactive model SFCL–STATCOM Controller is proposed to enhance the transient stability. •The STATCOM controller is integrated in coordination with the SFCL to support the excessive reactive power during fault. •Voltage stability index based continuation power flow is used to locate the STATCOM and the SFCL. •The clearing time improved compared to other cases (with only SFCL, with only STATCOM). •The choice of the STATCOM parameters is very important to exploit efficiently the integration of STATCOM Controller. -- Abstract: Stable and reliable operation of the power system network is dependent on the dynamic equilibrium between energy production and power demand under large disturbance such as short circuit or important line tripping. This paper investigates the use of combined model based superconducting fault current limiter (SFCL) and shunt FACTS Controller (STATCOM) for assessing the transient stability of a power system considering the automatic voltage regulator. The combined model located at a specified branch based on voltage stability index using continuation power flow. The main role of the proposed combined model is to achieve simultaneously a flexible control of reactive power using STATCOM Controller and to reduce fault current using superconducting technology based SFCL. The proposed combined model has been successfully adapted within the transient stability program and applied to enhance the transient power system stability of the WSCC9-Bus system. Critical clearing time (CCT) has been used as an index to evaluate and validate the contribution of the proposed coordinated Controller. Simulation results confirm the effectiveness and perspective of this combined Controller to enhance the dynamic power system performances.

  5. Laser frequency stabilization by combining modulation transfer and frequency modulation spectroscopy.

    Science.gov (United States)

    Zi, Fei; Wu, Xuejian; Zhong, Weicheng; Parker, Richard H; Yu, Chenghui; Budker, Simon; Lu, Xuanhui; Müller, Holger

    2017-04-01

    We present a hybrid laser frequency stabilization method combining modulation transfer spectroscopy (MTS) and frequency modulation spectroscopy (FMS) for the cesium D2 transition. In a typical pump-probe setup, the error signal is a combination of the DC-coupled MTS error signal and the AC-coupled FMS error signal. This combines the long-term stability of the former with the high signal-to-noise ratio of the latter. In addition, we enhance the long-term frequency stability with laser intensity stabilization. By measuring the frequency difference between two independent hybrid spectroscopies, we investigate the short-and long-term stability. We find a long-term stability of 7.8 kHz characterized by a standard deviation of the beating frequency drift over the course of 10 h and a short-term stability of 1.9 kHz characterized by an Allan deviation of that at 2 s of integration time.

  6. Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Bauer, Michael; Nolen, Willem A.

    2018-01-01

    Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination. Methods: As part of the International Society for Bipolar Disorders (ISBD) Task...... Force on Lithium Treatment, we undertook a systematic literature search of non-randomized controlled observational studies on (i) lithium monotherapy vs treatment with another maintenance mood stabilizer in monotherapy and (ii) lithium in combination with other mood stabilizers vs monotherapy. Results......: In eight out of nine identified studies including a total of lithium monotherapy was associated with improved outcome compared with another mood stabilizer in monotherapy, including valproate, lamotrigine, olanzapine, quetiapine, unspecified anticonvulsants, carbamazepine...

  7. Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of aspirin tablets

    Directory of Open Access Journals (Sweden)

    Xiuzhi Wang

    2017-05-01

    Full Text Available Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub- and outercoating combined with enteric aqueous coating. The main aim was to investigate the influence of these factors on the stability of ASA and understand how they work. Satisfactory storage stability were obtained when the aspirin tablet core coated with Eudragit L30D55 film was combined with glycerin monostearate (GMS as an outercoat. Hygroscopicity testing indicated that the moisture penetrating into the tablet may result in a significant change in the physical properties of the coating film observed by scanning electron microscopy. Investigation of the compatibility between the drug and film excipients shows that the talc and methacrylic acid had a significant catalytic effect on ASA. A hypothesis was proposed that the hydrolysis of ASA enteric coated tablets (ASA-ECT was mostly concentrated in the internal film and the interfaces between the film and tablet core. In conclusion, hot-melt coating technology is an alternative to subcoating or outercoating. Also, GMS sub-coating was a better choice for forming a stable barrier between the tablet core and the polymer coating layer, and increases the structure and chemical stability.

  8. Analysis on complex structure stability under different bar angle with BIM technology

    Directory of Open Access Journals (Sweden)

    Wang Xiongjue

    2016-03-01

    Full Text Available Sun Valley, the landmark building of World Expo in Shanghai, which has free surface with single-layer reticulated shell structure, is a typical complex structure. CAD/CAM integrated information system to design is used for the complex structure; however, it is a very rigorous process to be used widely. The relevant technology of the Sun Valley is not open to the public at present, so we try to use BIM technology to model the Sun Valley, including architecture modelling and structure analysis. By analysis of the Sun Valley structure using this method, it is proved that the problems in modelling may be solved by writing some script codes in Rhino software and the stability of the model can also be analyzed. The new approach is viable and effective in combination with different softwares such as Rhino, Revit, and Midas in solution of the complex shaped surfaces’ structure for modelling and calculation.

  9. The importance of tracer technology in combined borehole investigations

    International Nuclear Information System (INIS)

    Zojer, H.

    1998-01-01

    In an experimental field for a waste disposal site, investigations have been carried out applying methods from geology, hydrology hydrogeology, hydrochemistry, environmental isotope hydrology and tracer technology. All data obtained result to a dynamic drainage model of groundwater. The combined interpretation of borehole data guarantees a high-grade knowledge of groundwater exfiltrating to the surface drainage, which enables proper control measures of the disposal site and an effective groundwater protection. (author)

  10. Global Practical Stabilization and Tracking for an Underactuated Ship - A Combined Averaging and Backstepping Approach

    Directory of Open Access Journals (Sweden)

    Kristin Y. Pettersen

    1999-10-01

    Full Text Available We solve both the global practical stabilization and tracking problem for an underactuated ship, using a combined integrator backstepping and averaging approach. Exponential convergence to an arbitrarily small neighbourhood of the origin and of the reference trajectory, respectively, is proved. Simulation results are included.

  11. The estimation of tax-benefit automatic stabilizers in Serbia: A combined micro-macro approach

    Directory of Open Access Journals (Sweden)

    Ranđelović Saša

    2013-01-01

    Full Text Available The large volatility of GDP due to the economic crisis, particularly in transition economies, has brought the issue of automatic stabilizers back into the focus of economic policy. The vast majority of empirical literature in this field relates to the estimation of the size of automatic stabilizers in developed countries, usually based on macroeconomic data. On the other hand empirical literature on this topic based on micro data, particularly for transition economies, is limited. This paper provides an evaluation of the size of automatic stabilizers in one transition economy (Serbia, by combining tax-benefit simulation modelling based on micro data and econometric methods based on macroeconomic data. The results show that, in the case of shock, around 17% of fall in market income would be absorbed by automatic stabilizers. Although the stabilizing effects of the tax-benefit system in Serbia are lower than in other European countries, the total size of automatic stabilizers is close to the average value in these countries, due to the higher elasticity of demand to income. The results also show that progressivity-enhancing income tax reform would only slightly increase automatic stabilizers, due to the large informal economy and the large share of agriculture in total households’ income.

  12. Technology of combined chemical-mechanical fabrication of durable coatings

    Science.gov (United States)

    Smolentsev, V. P.; Ivanov, V. V.; Portnykh, A. I.

    2018-03-01

    The article presents the scientific fundamentals of methodology for calculating the modes and structuring the technological processes of combined chemical-mechanical fabrication of durable coatings. It is shown that they are based on classical patterns, describing the processes of simultaneous chemical and mechanical impact. The paper demonstrates the possibility of structuring a technological process, taking into account the systematic approach to impact management and strengthening the reciprocal positive influence of each impact upon the combined process. The combined processes have been planned for fabricating the model types of chemical-mechanical coatings of durable products in machine construction. The planning methodology is underpinned by a scientific hypothesis of a single source of impact management through energy potential of process components themselves, or by means of external energy supply through mechanical impact. The control of it is fairly thoroughly studied in the case of pulsed external strikes of hard pellets, similar to processes of vibroimpact hardening, thoroughly studied and mastered in many scientific schools of Russia.

  13. Combining overt and covert anti-counterfeiting technologies for securities

    Science.gov (United States)

    Uematsu, Tsuyoshi

    2006-02-01

    The National Printing Bureau of Japan has been developing new anti-counterfeiting technologies as a banknote printer. Some of our technologies have already been effectively introduced into Japan's new banknote series. Anti-counterfeiting technologies can be applied not only to banknotes but also to other security documents depending on desired features. In this presentation, I will introduce three of our newly developed overt and covert security techniques, which are intended for document security and brand protection, as well as banknotes. "Metallic View" is mainly for offset printing. "Copy Check" (micro-structural lines involving luminescence) is for plate making technology. "ImageSwitch" is for a new security solution which has unlimited printing applications. All three techniques create "latent images" (some of which may be better known as "carrier screen images") that are useful in preventing counterfeiting. While each of the techniques is effective by itself, all are more effective when applied together. Combining these techniques could make all security documents harder to copy using IT scanners, and provide cost-effective anti-counterfeiting solutions for all security users.

  14. Advantages of combining an EBIS with the PIGMI technology

    International Nuclear Information System (INIS)

    Hamm, R.W.

    1980-01-01

    The Electron Beam Ion Source (EBIS) produces highly charged heavy ions by electron impact ionization of ions electrostatically trapped within a dense energetic electron beam. Because of its pulsed operation and the highly charged ions produced, the EBIS is ideally suited as an injector for a high-gradient, low duty-cycle linac such as that being developed at the Los Alamos Scientific Laboratory (LASL) in the program to design a Pion Generator for Medical Irradiation (PIGMI). This combination of new technologies would produce an efficient, small heavy ion linac useful in a variety of research and practical applications

  15. Technological feasibility studies on combination treatments for subtropical fruits

    International Nuclear Information System (INIS)

    Brodrick, H.T.; Linde, H.J. van der

    1981-01-01

    Research with subtropical fruits such as papayas and mangoes had advanced beyond the experimental stage in South Africa. This may be attributed to the potential economic benefits likely to be obtained from the combination of heat and irradiation treatments. The outcome of recent marketing trials, however, revealed several problem areas which need further investigation. Some of these problems were studied in greater detail and are reported in this presentation. The effect of time delays between hot-water and irradiation treatments on the efficacy in disease control in the fruit, has received particular attention in the investigations. Efforts have also been made to correlate these results with those obtained in fungal studies in the laboratory. These and other factors relating to the technological feasibility in the use of combined treatments for the preservation of mangoes and papayas are discussed and recommendations or guidelines for future studies are given in this paper. (author)

  16. Technology of Rock Destruction by Combined Explosion-Mechanical Load

    Directory of Open Access Journals (Sweden)

    Oleg M. Terentiev

    2017-10-01

    Full Text Available Background. Rock drilling is characterized by an energy capacity of more than 120 kWh/m3. This is due to the fact that about 90 % of the energy is expended on the “preparation” of rocks for destruction. This study proposes to combine explosive and mechanical loads to reduce specific energy consumption of rock destruction. Objective. The aim of the paper is energy effective technology development for rock destruction by combined explosive-mechanical loads. Methods. Analytical studies; regression analysis; math modeling; experimental research; technical and economic analysis. Results. Specific energy decreasing for explosive-mechanical rock drilling by 4–16 % was experimentally proved. Conclusions. As a result of the implementation of explosive-mechanical rock drilling on the created full-sized experimental device, the efficiency coefficient increased from 77 to 80 %.

  17. Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations

    Directory of Open Access Journals (Sweden)

    Patrícia Maria Berardo Gonçalves Maia Campos

    2012-02-01

    Full Text Available Chemically stable ester derivatives of vitamins A, C and E have become a focus of interest for their role in the satisfactory results in skin aging treatments. Accordingly, the aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing 1% retinyl palmitate, ascorbyl tetraisopalmitate and tocopheryl acetate, alone or in combination. In the studies of physical stability, a Brookfield rheometer was used to determine rheological behavior of formulations containing the vitamins. Chemical stability was determined by HPLC on a Shimadzu system with UV detection. Results showed that formulations had pseudoplastic behavior and that vitamins did not alter their apparent viscosity and thixotropy. In the chemical stability studies, first-order reaction equations were used for determinations of the shelf-life of vitamins derivatives considering a remaining concentration of 85%. Combined vitamins in a single formulation had a slightly lower degradation rate as compared to different preparations containing only one of the vitamins. Considering that many cosmetic formulations contain vitamin combinations it is suggested that the present study may contribute to the development of more stable formulations containing liposoluble vitamins.

  18. Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations.

    Science.gov (United States)

    Gianeti, Mirela Donato; Gaspar, Lorena Rigo; Camargo, Flávio Bueno de; Campos, Patrícia Maria Berardo Gonçalves Maia

    2012-02-22

    Chemically stable ester derivatives of vitamins A, C and E have become a focus of interest for their role in the satisfactory results in skin aging treatments. Accordingly, the aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing 1% retinyl palmitate, ascorbyl tetraisopalmitate and tocopheryl acetate, alone or in combination. In the studies of physical stability, a Brookfield rheometer was used to determine rheological behavior of formulations containing the vitamins. Chemical stability was determined by HPLC on a Shimadzu system with UV detection. Results showed that formulations had pseudoplastic behavior and that vitamins did not alter their apparent viscosity and thixotropy. In the chemical stability studies, first-order reaction equations were used for determinations of the shelf-life of vitamins derivatives considering a remaining concentration of 85%. Combined vitamins in a single formulation had a slightly lower degradation rate as compared to different preparations containing only one of the vitamins. Considering that many cosmetic formulations contain vitamin combinations it is suggested that the present study may contribute to the development of more stable formulations containing liposoluble vitamins.

  19. Justification of working out of combine harvesters technological certificate

    Directory of Open Access Journals (Sweden)

    G. E. Chepurin

    2016-01-01

    Full Text Available Dynamics of grain crops productivity in the main grain growing regions of Siberian Federal District is presented. Major factors shoud be considered at justification of a class of combine harvesters for their effective operation in various climatic and working conditions. loading efficiency of a combine thresher depends on productivity and operating width of windrowers or headers at straight-cutting and windrowing. A tailings maintenance in the threshed grain heap influences on the harvester capacity. Certificate capacity of combines of a class of 5-12 kg/s at the 1.5 percent admissible level of losses behind a combine thresher is depending on the tailings maintenance in the threshed grain heap. In accordance to analysis the capacity of combines of any class of the classical design increases by 1.45 times at reduction of a straw content from 1.5 to 0.7 relative to standard indicators, and decreases by 1.16 times at increase of this parameter to 2.3. The combine of a class of 7 kg/s is completely loaded when pickup threshing by harvesters with a operating width of 20; 16 and 12 m at a speed of movement 7.2; 9.0 and 12.0 km/h respectively. The combine of a class of 10 kg/s at crop productivity of 1.8 t/ha will be completely loaded when pickup threshing if the operating width is 20 m and the speed equals 12 km/h, and at the width of 16 m speed has to make 13 km/h. The content of the technological certificate by the example of use of combines of a class of 7 kg/s (GS-07 and 10 kg/s (GS-10 is proved. The algorithm of determination of the movement speed is presented. Its use provides certificate loading of a thresher when threshing of grain crops with different productivity at straight-cutting and windrowing.

  20. Combining technologies - radiography and neutron based - for cargo security applications

    International Nuclear Information System (INIS)

    Gozani, T.; Liu, F.; Sivakumar, M.; Brown, D.

    2004-01-01

    Inspection of air and sea cargo has traditionally been done by X-ray systems of various energies relying on operators to analyze images looking for anomalies in the image of cargo that may signify a threat. This has shown only limited success in detecting explosives and other threats, which do not have any distinctive shapes. OSI Systems, through its subsidiaries Rapiscan and Ancore, has combined high-energy x-ray radiography with thermal neutron analysis (TNA) to create the combined system-''TNX''. The system provides automatic material specific detection of bulk threat items, like explosives, while furnishing the operator with a high-resolution image for weapons detection and also to identify anomalies for the TNA to inspect. Similarly the Pulsed Fast Neutron Analysis (PFNA) can be combined with high-energy x-ray to create a ''FNX'' system for both air and sea cargo applications. This enables the operator obtain a three dimensional image of the material composition of the cargo under inspection and remove the clutter from the image leaving only the potentially hazardous material(s) automatically while viewing a high resolution image for manifest verification and weapons. The current status of the technology will be discussed and data be presented

  1. A Combination of PD Controller and PIAFC for Stabilization of “x” Configuration Quadcopter

    Directory of Open Access Journals (Sweden)

    Ni’am Tamami

    2014-06-01

    Full Text Available This paper presents a stabilization control method for “x” configuration quadcopter. The control method used the combination of PD (Proportional Derivative controller and PIAFC (Proportional Integral Active Force Control. PD is used to stabilize quadcopter, and PIAFC is used to reject uncertainty disturbance (e.g. wind by estimating disturbance torque value of quadcopter. The PD with PIAFC provided better result where PIAFC could minimize uncertain disturbance effect. The simulation has successfully give comparation about controller performance (PD, PD-AFC, PD-PIAFC by calculate RMS (Root Mean Square value. PD with AFC gives better result than PD. AFC optimization using PI (PD-PIAFC give best result if compared with PD or PD-AFC. PD-PIAFC has lowest RMS value of result control signal, 0.0389 for constant disturbance and 0.1008 for fluctuated disturbance. Keywords:“x” configuration quadcopter, stability, PD, PIAFC.

  2. Identification of drug combinations administered by continuous subcutaneous infusion that require analysis for compatibility and stability.

    Science.gov (United States)

    Dickman, Andrew; Bickerstaff, Matthew; Jackson, Richard; Schneider, Jennifer; Mason, Stephen; Ellershaw, John

    2017-03-23

    A continuous subcutaneous infusion (CSCI) delivered via syringe pump is a method of drug administration used to maintain symptom control when a patient is no longer able to tolerate oral medication. Several classes of drugs, such as opioids, antiemetics, anticholinergics, antipsychotics and benzodiazepines are routinely administered by CSCI alone or in combinations. Previous studies attempting to identify the most-common CSCI combinations are now several years old and no longer reflect current clinical practice. The aim of this work was to review current clinical practice and identify CSCI drug combinations requiring analysis for chemical compatibility and stability. UK pharmacy professionals involved in the delivery of care to palliative patients in hospitals and hospices were invited to enter CSCI combinations comprised of two or more drugs onto an electronic database over a 12-month period. In addition, a separate Delphi study with a panel of 15 expert healthcare professionals was completed to identify a maximum of five combinations of drugs used to treat more complex, but less commonly encountered symptoms unlikely to be identified by the national survey. A total of 57 individuals representing 33 separate palliative care services entered 1,945 drug combinations suitable for analysis, with 278 discrete combinations identified. The top 40 drug combinations represented nearly two-thirds of combinations recorded. A total of 23 different drugs were administered in combination and the median number of drugs in a combination was three. The Delphi study identified five combinations for the relief of complex or refractory symptoms. This study represents the first step towards developing authoritative national guidance on the administration of drugs by CSCI. Further work will ensure healthcare practitioners have the knowledge and confidence that a prescribed combination will be both safe and efficacious.

  3. Application of simplex-centroid mixture design to optimize stabilizer combinations for ice cream manufacture.

    Science.gov (United States)

    BahramParvar, Maryam; Tehrani, Mostafa Mazaheri; Razavi, Seyed M A; Koocheki, Arash

    2015-03-01

    This study aimed to obtain the optimum formulation for stabilizers in ice cream that could contest with blends presented nowadays. Thus, different mixtures of three stabilizers, i.e. basil seed gum, carboxymethyl cellulose, and guar gum, at two concentrations (0.15 % & 0.35 %) were studied using mixture design methodology. The influence of these mixtures on some properties of ice cream and the regression models for them were also determined. Generally, high ratios of basil seed gum in mixture developed the apparent viscosity of ice cream mixes and decreased the melting rate. Increasing proportion of this stabilizer as well as guar gum in the mixtures at concentration of 0.15 % enhanced the overrun of samples. Based on the optimization criteria, the most excellent combination was 84.43 % basil seed gum and 15.57 % guar gum at concentration of 0.15 %. This research proved the capability of basil seed gum as a novel stabilizer in ice cream stabilization.

  4. Effects of combinative surface modification on the stability and conductivity of the copper particles

    International Nuclear Information System (INIS)

    Zeng, Yike; Li, Tongtong; Fu, Ming; Jiang, Shenglin; Zhang, Guangzu

    2014-01-01

    Highlights: • A combinative method is used to improve the performance of the copper powder. • The method integrates passivation, silver-coating, and coupling agent treatment. • The stability of the copper powder has been improved after the modification. • The sheet resistance of the conductive film is reduced to 15 mΩ. -- Abstract: The specific goal of the present study is to evaluate the surface performance of the copper particles and get excellent copper powder by surface modification. This paper proposes a combinative modification method integrating passivation, silver-coated, and coupling agent. As a result, after 600 h at room temperature the copper powder has the stabilization improved and is well combined with organic matters, and the sheet resistance of the film fabricated by the copper conductive filler is reduced to 15 mΩ. The performance of the copper powder has been greatly enhanced by the combinative modification, and the cost of the copper conductive filler is decreased significantly by this method. The results indicate that the combinative surface modification method can be used for practical electronic application

  5. EVALUATION OF SOLIDIFICATION/STABILIZATION AS A BEST DEMONSTRATED AVAILABLE TECHNOLOGY FOR CONTAMINATED SOILS

    Science.gov (United States)

    This project involved the evaluation of solidification/stabilization technology as a BDAT for contaminated soil. Three binding agents were used on four different synthetically contaminated soils. Performance evaluation data included unconfined compressive strength (UCS) and the T...

  6. Deacidification of Soybean Oil Combining Solvent Extraction and Membrane Technology

    Directory of Open Access Journals (Sweden)

    M. L. Fornasero

    2013-01-01

    Full Text Available The aim of this work was to study the removal of free fatty acids (FFAs from soybean oil, combining solvent extraction (liquid-liquid for the separation of FFAs from the oil and membrane technology to recover the solvent through nanofiltration (NF. Degummed soybean oil containing 1.05 ± 0.10% w/w FFAs was deacidified by extraction with ethanol. Results obtained in the experiences of FFAs extraction from oil show that the optimal operating conditions are the following: 1.8 : 1 w : w ethanol/oil ratio, 30 minutes extraction time and high speed of agitation and 30 minutes repose time after extraction at ambient temperature. As a result of these operations two phases are obtained: deacidified oil phase and ethanol phase (containing the FFAs. The oil from the first extraction is subjected to a second extraction under the same conditions, reducing the FFA concentration in oil to 0.09%. Solvent recovery from the ethanol phase is performed using nanofiltration technology with a commercially available polymeric NF membrane (NF-99-HF, Alfa Laval. From the analysis of the results we can conclude that the optimal operating conditions are pressure of 20 bar and temperature of 35°C, allowing better separation performance: permeate flux of 28.3 L/m2·h and FFA retention of 70%.

  7. Use of solidification/stabilization treatment technology for environmental remediation in the United States and Canada

    International Nuclear Information System (INIS)

    Wilk, C.M.

    2002-01-01

    In the United States (U.S.) Solidification/Stabilization (S/S) treatment is used to treat hazardous wastes for disposal, and in the remediation/site restoration of contaminated land. S/S is also an increasingly popular technology for Brownfields (industrial property) redevelopment since treated wastes can often be left on-site and to actually improve the site's soil for subsequent construction. The U.S. Environmental Protection Agency (EPA) considers S/S to be an established treatment technology. EPA has identified S/S treatment as Best Demonstrated Available Treatment Technology (BDAT) for at least 57 commonly produced industrial wastes (Resource Conservation and Recovery Act (RCRA)-listed hazardous wastes) and has selected S/S treatment for 25% of its Superfund (abandoned or uncontrolled) site remediation projects. S/S treatment involves mixing a binding reagent into the contaminated media or waste. Successful treatment is accomplished through physical changes to the waste form, and often, chemical changes to the hazardous constituents themselves. Commonly used S/S binding reagents in include portland cement, cement kiln dust, lime, lime kiln dust and fly ash. These materials are used alone or in combination. Proprietary reagents are also beginning to be marketed and used in the U.S. and Canada. This paper will discuss: (a) applicability of the technology to various wastes, (b) basic cement chemistry relating to S/S, (c) tests used to design treatability studies and to verify treatment, (d) basics on implementation of the technology in the field, and (e) examples of actual projects. (author)

  8. Combining in situ chemical oxidation, stabilization, and anaerobic bioremediation in a single application to reduce contaminant mass and leachability in soil.

    Science.gov (United States)

    Cassidy, Daniel P; Srivastava, Vipul J; Dombrowski, Frank J; Lingle, James W

    2015-10-30

    Laboratory batch reactors were maintained for 32 weeks to test the potential for an in situ remedy that combines chemical oxidation, stabilization, and anaerobic bioremediation in a single application to treat soil from a manufactured gas plant, contaminated with polycyclic aromatic hydrocarbons (PAH) and benzene, toluene, ethylbenzene, and xylenes (BTEX). Portland cement and slaked lime were used to activate the persulfate and to stabilize/encapsulate the contaminants that were not chemically oxidized. Native sulfate-reducing bacteria degraded residual contaminants using the sulfate left after persulfate activation. The ability of the combined remedy to reduce contaminant mass and leachability was compared with NaOH-activated persulfate, stabilization, and sulfate-reducing bioremediation as stand-alone technologies. The stabilization amendments increased pH and temperature sufficiently to activate the persulfate within 1 week. Activation with both stabilization amendments and NaOH removed between 55% and 70% of PAH and BTEX. However, combined persulfate and stabilization significantly reduced the leachability of residual BTEX and PAH compared with NaOH activation. Sulfide, 2-naphthoic acid, and the abundance of subunit A of the dissimilatory sulfite reductase gene (dsrA) were used to monitor native sulfate-reducing bacteria, which were negatively impacted by activated persulfate, but recovered completely within weeks. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Uncertain R and D, backstop technology and GHGs stabilization

    International Nuclear Information System (INIS)

    Bosetti, Valentina; Tavoni, Massimo

    2009-01-01

    This paper analyses optimal investments in innovation when dealing with a stringent climate target and with the uncertain effectiveness of R and D. The innovation needed to achieve the deep cut in emissions is modeled by a backstop carbon-free technology whose cost depends on R and D investments. To better represent the process of technological progress, we assume that R and D effectiveness is uncertain. By means of a simple analytical model, we show how accounting for the uncertainty that characterizes technological advancement yields higher investments in innovation and lower policy costs. We then confirm the results via a numerical analysis performed with a stochastic version of WITCH, an energy-economy-climate model. The results stress the importance of a correct specification of the technological change process in economy-climate models. (author)

  10. Technologies for Hemostasis and Stabilization of the Acute Traumatic Wound

    Science.gov (United States)

    2014-10-01

    Thomas D. Morris Institute TEG thromboelastography UMM University of Maryland Medical Center UNL University of Nebraska—Lincoln UNMC University of...two subjects, and see what happens. VII. PLAN On the next three consecutive Tuesdays (Mar 25, Apr 1, Apr 8), we will be...Stabilization of the Acute Traumatic Wound" Jessica, Drs. Velander, Larsen, and I have decided to cancel our subcontract with the Thomas D. Morris Institute

  11. Transient Stability Improvement for Combined Heat and Power System Using Load Shedding

    Directory of Open Access Journals (Sweden)

    Hung-Cheng Chen

    2014-01-01

    Full Text Available The purpose of the paper is to analyze and improve the transient stability of an industrial combined heat and power (CHP system in a high-tech science park in Taiwan. The CHP system installed two 161 kV/161 kV high-impendence transformers to connect with Taipower System (TPS for both decreasing the short-circuit fault current and increasing the fault critical clearing time. The transient stabilities of three types of operation modes in CHP units, 3G1S, 2G1S, and 1G1S, are analyzed. Under the 3G1S operation mode, the system frequency is immediately restored to 60 Hz after tie line tripping with the TPS. Under the 1G1S and 2G1S operation modes, the system frequencies will continuously decrease and eventually become unstable. A novel transient stability improvement approach using load shedding technique based on the change in frequency is proposed to improve the transient stability.

  12. Thermogravimetric studies of the thermo-oxidative stability of irradiated and unirradiated polyethylene. 2. Combined antioxidants

    Energy Technology Data Exchange (ETDEWEB)

    Novakovic, L; Gal, O; Markovic, V; Stannett, V T

    1985-01-01

    In part one of this series the effects of a phenolic, an amine and a thioester antioxidant on the thermo-oxidative stability of irradiated and unirradiated low-density polyethylene was reported. In this paper the effects of combined phenolic and thioester stabilizers are described. Isothermal thermogravimetric analysis was used to study the systems. Pronounced synergism was observed with the induction periods, the time when the initial weight loss begins and the 5% weight loss. At about 50% of each stabilizer increases greater than twofold were observed both with the unirradiated and irradiated polymers. The rate constants for oxygen uptake were decreased. However, the rates of degradation at 5% weight loss fell between the values of the two pure stabilizers with no pronounced synergism in either case. In the absence of oxygen little effect of either antioxidant or their mixtures was observed. The corresponding activation energies were somewhat higher, however, with the irradiated samples containing antioxidants. Dynamic thermogravimetry was used for this study. A kinetic analysis indicated that there were somewhat different modes of degradation at lower- and higher-temperature ranges. (author).

  13. Combined Neutron Center for European Research and Technology

    International Nuclear Information System (INIS)

    Lagniel, Jean-Michel

    2002-01-01

    High-power proton linacs are needed as driver for several applications, namely transmutation of nuclear waste using Accelerator Driven Systems (ADS), spallation neutron sources (ESS in Europe) and other fields of basic and applied research (next generation of radioactive ion beam facilities, neutrino factories, muon colliders, irradiation facilities for material testing...). The possible synergies among these projects will be pointed out and the feasibility study of high-power proton linac used as driver of a multi-user facility (CONCERT) will be presented. There was excellent scientific, technical and economic reasons to study a Combined Neutron Center for European Research and Technology (CONCERT) based on a high-power proton accelerator. Such an installation would serve condensed matter studies by spallation neutron scattering, a technological irradiation tool and R and D facility for an hybrid reactor demonstrator, a radioactive ion beam facility for nuclear physics, R and D developments for a muon/neutrino facility. The installation could therefore constitute a European center of excellence in the field of neutronics where a large number of scientific and technical executives could be trained. The CONCERT Project Team has performed the feasibility study of such a multi-user facility with: - a review of the beam needs for the different applications, - an analyze of their compatibility, - the definition of the scope of a site-independent project, - a selection of the most appropriate options regarding scientific, technical, financial, organizational and administrative aspects, - an estimation of the costs for construction, operation and the needs in manpower. The conceptual design report [17] is sufficiently detailed to minimize contingencies on those parts of the project having a large potential impact in terms of performances, costs or delays. (author)

  14. Superfund Innovative Technology Evaluation - Demonstration Bulletin: In-Situ Soil Stabilization

    Science.gov (United States)

    In-situ stabilization technology immobilizes organics and inorganic compounds in wet or dry soils by using reagents (additives) to polymerize with the soils and sludges producing a cement-like mass. Two basic components of this technology are the Geo-Con/DSM Deep Soil Mixing Sy...

  15. Cleaner Technologies and the Stability of International Environmental Agreements

    NARCIS (Netherlands)

    Benchekroun, H.; Ray Chaudhuri, A.

    2012-01-01

    Abstract: This paper shows that, if countries are farsighted when deciding whether to defect from a coalition, then the implementation of cleaner technologies may jeopardize the chances of reaching an international environmental agreement. The grand coalition may be destabilized by the

  16. Maize forage aptitude: Combining ability of inbred lines and stability of hybrids

    Directory of Open Access Journals (Sweden)

    Luis Máximo Bertoia

    2014-12-01

    Full Text Available Breeding of forage maize should combine improvement achieved for grain with the specific needs of forage hybrids. Production stability is important when maize is used for silage if the planting area is not in the ideal agronomic environment. The objectives of the present research were: (i to quantify environmental and genetic and their interaction effects on maize silage traits; (ii to identify possible heterotic groups for forage aptitude and suggest the formation of potential heterotic patterns, and (iii to identify suitable inbred line combinations for producing hybrids with forage aptitude. Forty-five hybrids derived from diallelic crosses (without reciprocals among ten inbred lines of maize were evaluated in this study. Combined ANOVA over environments showed differences between genotypes (G, environments (E, and their interactions (GEI. Heritability (H2, and genotypic and phenotypic correlations were estimated to evaluate the variation in and relationships between forage traits. Postdictive and predictive AMMI models were fitted to determine the importance of each source of variation, G, E, and GEI, and to select genotypes simultaneously on yield, quality and stability. A predominance of additive effects was found in the evaluated traits. The heterotic pattern Reid-BSSS × Argentine flint was confirmed for ear yield (EY and harvest index (HI. High and broad genetic variation was found for stover and whole plant traits. Some inbred lines had genes with differential breeding aptitude for ear and stover. Stover and ear yield should be the main breeding objectives in maize forage breeding.

  17. Comparison of Different Technologies for Integrated Solar Combined Cycles: Analysis of Concentrating Technology and Solar Integration

    Directory of Open Access Journals (Sweden)

    Antonio Rovira

    2018-04-01

    Full Text Available This paper compares the annual performance of Integrated Solar Combined Cycles (ISCCs using different solar concentration technologies: parabolic trough collectors (PTC, linear Fresnel reflectors (LFR and central tower receiver (CT. Each solar technology (i.e. PTC, LFR and CT is proposed to integrate solar energy into the combined cycle in two different ways. The first one is based on the use of solar energy to evaporate water of the steam cycle by means of direct steam generation (DSG, increasing the steam production of the high pressure level of the steam generator. The other one is based on the use of solar energy to preheat the pressurized air at the exit of the gas turbine compressor before it is introduced in the combustion chamber, reducing the fuel consumption. Results show that ISCC with DSG increases the yearly production while solar air heating reduces it due to the incremental pressure drop. However, air heating allows significantly higher solar-to-electricity efficiencies and lower heat rates. Regarding the solar technologies, PTC provides the best thermal results.

  18. [Recent advance in solidification/stabilization technology for the remediation of heavy metals-contaminated soil].

    Science.gov (United States)

    Hao, Han-zhou; Chen, Tong-bin; Jin, Meng-gui; Lei, Mei; Liu, Cheng-wu; Zu, Wen-pu; Huang, Li-mi

    2011-03-01

    Remediation of heavy metals-contaminated soil is still a difficulty and a hotspot of international research projects. At present, the technologies commonly adopted for the remediation of contaminated sites mainly include excavation, solidification/stabilization (S/S), soil washing, soil vapor extraction (SVE), thermal treatment, and bioremediation. Based on the S/S technical guidelines of Unite State Environmental Protection Agency (EPA) and United Kingdom Environment Agency (EA) and the domestic and foreign patents, this paper introduced the concepts of S/S and its development status at home and abroad, and discussed its future development directions. Solidification refers to a process that binds contaminated media with a reagent, changing the media's physical properties via increasing its compressive strength, decreasing its permeability, and encapsulating the contaminants to form a solid material. Stabilization refers to the process that involves a chemical reaction which reduces the leachability of a waste, chemically immobilizes the waste and reduces its solubility, making the waste become less harmful or less mobile. S/S technology includes cement solidification, lime pozzolanic solidification, plastic materials stabilization, vitrification, and regent-based stabilization. Stabilization (or immobilization) treatment processes convert contaminants to less mobile forms through chemical or thermal interactions. In stabilization technology, the aim of adding agents is to change the soil physical and chemical properties through pH control technology, redox potential technology, precipitation techniques, adsorption technology, and ion-exchange technology that change the existing forms of heavy metals in soil, and thus, reduce the heavy metals bioavailability and mobility. This review also discussed the S/S evaluation methods, highlighted the need to enhance S/S technology in the molecular bonding, soil polymers, and formulation of China's S/S technical guidelines.

  19. Stabilization of car-caravan combination using independent steer and drive/or brake forces distribution

    Directory of Open Access Journals (Sweden)

    Ossama Mokhiamar

    2015-09-01

    Full Text Available Once a combined vehicle becomes unstable, it is very difficult for a driver to stabilize it especially under severe driving conditions, such as turning with braking. This is mainly due to the effect of the towed vehicle on the towing vehicle through the hitch jackknifing. This effect makes the handling characteristics of a car-caravan combination different from those of a single vehicle. Therefore, this paper proposes a control design concept for an optimum distribution of longitudinal and lateral forces of the four tires of a towing vehicle. The mean objectives of the control system were to stabilize the motion of an articulated vehicle utilizing the tires entire ability in both longitudinal and lateral directions as well as to make the handling characteristics of an articulated vehicle similar to those of a single one. The sliding control law based on vehicle planar equations of motion is used to derive the control laws. The proposed control system is evaluated under severe driving conditions and compared with the results of integrated control systems. The robustness of the articulated vehicle motion with the proposed control against the coefficient of friction variation is discussed.

  20. mHealth Application Areas and Technology Combinations.

    Science.gov (United States)

    Abaza, Haitham; Marschollek, Michael

    2017-01-01

    With the continuous and enormous spread of mobile technologies, mHealth has evolved as a new subfield of eHealth. While eHealth is broadly focused on information and communication technologies, mHealth seeks to explore more into mobile devices and wireless communication. Since mobile phone penetration has exceeded other infrastructure in low and middle-income countries (LMICs), mHealth is seen as a promising component to provide pervasive and patient-centered care. The aim of our research work for this paper is to examine the mHealth literature to identify application areas, target diseases, and mHealth service and technology types that are most appropriate for LMICs. Based on the 2011 WHO mHealth report, a combination of search terms, all including the word "mHealth", was identified. A literature review was conducted by searching the PubMed and IEEE Xplore databases. Articles were included if they were published in English, covered an mHealth solution/intervention, involved the use of a mobile communication device, and included a pilot evaluation study. Articles were excluded if they did not provide sufficient detail on the solution covered or did not focus on clinical efficacy/effectiveness. Cross-referencing was also performed on included articles. 842 articles were retrieved and analyzed, 255 of which met the inclusion criteria. North America had the highest number of applications (n=74) followed by Europe (n=50), Asia (n=44), Africa (n=25), and Australia (n=9). The Middle East (n=5) and South America (n=3) had the least number of studies. The majority of solutions addressed diabetes (n=51), obesity (n=25), CVDs (n=24), HIV (n=18), mental health (n=16), health behaviors (n=16), and maternal and child's health (MCH) (n=11). Fewer solutions addressed asthma (n=7), cancer (n=5), family health planning (n=5), TB (n=3), malaria (n=2), chronic obtrusive pulmonary disease (COPD) (n=2), vision care (n=2), and dermatology (n=2). Other solutions targeted stroke, dental

  1. Combining in situ chemical oxidation, stabilization, and anaerobic bioremediation in a single application to reduce contaminant mass and leachability in soil

    Energy Technology Data Exchange (ETDEWEB)

    Cassidy, Daniel P., E-mail: daniel.cassidy@wmich.edu [Department of Geosciences, Western Michigan University, Kalamazoo, MI 49008 (United States); Srivastava, Vipul J., E-mail: vipul.srivastava@ch2m.com [CH2M HILL, 125S Wacker, Ste 3000, Chicago, IL 60606 (United States); Dombrowski, Frank J., E-mail: frank.dombrowski@we-energies.com [We Energies, 333W Everett St., A231, Milwaukee, WI 53203 (United States); Lingle, James W., E-mail: jlingle@epri.com [Electric Power Research Institute (EPRI), 4927W Willow Road, Brown Deer, WI 53223 (United States)

    2015-10-30

    Highlights: • Portland cement and lime activated persulfate by increasing pH and temperature. • Chemical oxidation achieved BTEX and PAH removal ranging from 55% to 75%. • Activating persulfate with ISS amendments reduced leachability more than NaOH. • Native sulfate-reducing bacteria degraded PAHs within weeks after ISCO finished. • ISCO, ISS, and anaerobic bioremediation were combined in a single application. - Abstract: Laboratory batch reactors were maintained for 32 weeks to test the potential for an in situ remedy that combines chemical oxidation, stabilization, and anaerobic bioremediation in a single application to treat soil from a manufactured gas plant, contaminated with polycyclic aromatic hydrocarbons (PAH) and benzene, toluene, ethylbenzene, and xylenes (BTEX). Portland cement and slaked lime were used to activate the persulfate and to stabilize/encapsulate the contaminants that were not chemically oxidized. Native sulfate-reducing bacteria degraded residual contaminants using the sulfate left after persulfate activation. The ability of the combined remedy to reduce contaminant mass and leachability was compared with NaOH-activated persulfate, stabilization, and sulfate-reducing bioremediation as stand-alone technologies. The stabilization amendments increased pH and temperature sufficiently to activate the persulfate within 1 week. Activation with both stabilization amendments and NaOH removed between 55% and 70% of PAH and BTEX. However, combined persulfate and stabilization significantly reduced the leachability of residual BTEX and PAH compared with NaOH activation. Sulfide, 2-naphthoic acid, and the abundance of subunit A of the dissimilatory sulfite reductase gene (dsrA) were used to monitor native sulfate-reducing bacteria, which were negatively impacted by activated persulfate, but recovered completely within weeks.

  2. Combining in situ chemical oxidation, stabilization, and anaerobic bioremediation in a single application to reduce contaminant mass and leachability in soil

    International Nuclear Information System (INIS)

    Cassidy, Daniel P.; Srivastava, Vipul J.; Dombrowski, Frank J.; Lingle, James W.

    2015-01-01

    Highlights: • Portland cement and lime activated persulfate by increasing pH and temperature. • Chemical oxidation achieved BTEX and PAH removal ranging from 55% to 75%. • Activating persulfate with ISS amendments reduced leachability more than NaOH. • Native sulfate-reducing bacteria degraded PAHs within weeks after ISCO finished. • ISCO, ISS, and anaerobic bioremediation were combined in a single application. - Abstract: Laboratory batch reactors were maintained for 32 weeks to test the potential for an in situ remedy that combines chemical oxidation, stabilization, and anaerobic bioremediation in a single application to treat soil from a manufactured gas plant, contaminated with polycyclic aromatic hydrocarbons (PAH) and benzene, toluene, ethylbenzene, and xylenes (BTEX). Portland cement and slaked lime were used to activate the persulfate and to stabilize/encapsulate the contaminants that were not chemically oxidized. Native sulfate-reducing bacteria degraded residual contaminants using the sulfate left after persulfate activation. The ability of the combined remedy to reduce contaminant mass and leachability was compared with NaOH-activated persulfate, stabilization, and sulfate-reducing bioremediation as stand-alone technologies. The stabilization amendments increased pH and temperature sufficiently to activate the persulfate within 1 week. Activation with both stabilization amendments and NaOH removed between 55% and 70% of PAH and BTEX. However, combined persulfate and stabilization significantly reduced the leachability of residual BTEX and PAH compared with NaOH activation. Sulfide, 2-naphthoic acid, and the abundance of subunit A of the dissimilatory sulfite reductase gene (dsrA) were used to monitor native sulfate-reducing bacteria, which were negatively impacted by activated persulfate, but recovered completely within weeks

  3. Electrochemical behavior and stability of a commercial activated carbon in various organic electrolyte combinations containing Li-salts

    International Nuclear Information System (INIS)

    Zhang, Tong; Fuchs, Bettina; Secchiaroli, Marco; Wohlfahrt-Mehrens, Margret; Dsoke, Sonia

    2016-01-01

    Highlights: • 1 M LiPF 6 in PC displays the widest electrochemical stability window among others couples electrolyte/activated carbon. • Electrolytes based on EC-DMC show lower impedance than electrolytes containing PC. • 1 M LiPF 6 in PC has the highest cycling stability with 75% of capacitance retention after 20 000 cycles. - Abstract: The fast development of Li-ion capacitor (LIC) technologies requires the use of low resistance and stable electrolytes. An electrolyte for a LIC not only has to provide Li for the intercalation/deintercalation of the battery-type materials, but it also needs to be compatible with the supercapacitor material. Before designing a hybrid Li-ion capacitor device containing Li-insertion and double layer-type materials, it is necessary to understand and separate the contribution of each electrode material to the resistance, capacity and stability in the chosen electrolyte. Due to the intensive research on Li-ion batteries, the interactions of Li-salt containing electrolytes combined with Li insertion materials have been extensively investigated, and a lot of literature is available on this field. In contrast, there is only little knowledge about the exclusive interaction and compatibility of Li containing electrolytes with supercapacitor-type electrode materials (in absence of battery materials). With this purpose, this paper explores the electrochemical performance of electrodes based on commercial activated carbon (AC) in various lithium salt-containing electrolytes. A standard electrolyte for Li-ion batteries (1 M LiPF 6 in EC:DMC, 1:1) is evaluated and compared with an electrolyte prepared with the same salt dissolved in propylene carbonate (1 M LiPF 6 in PC) which is a solvent typically used in commercial supercapacitors. Furthermore, two new electrolyte solutions are proposed, based on a blend of salts 0.8 M LiPF 6 + 0.2 M NEt 4 BF 4 in EC:DMC (1:1) as well as in pure PC. The effect of the electrolyte composition is evaluated

  4. Study on commercial FBR concepts by combining innovative technologies

    International Nuclear Information System (INIS)

    Miura, M.; Inagaki, T.; Kuroha, M.; Hida, T.

    1992-01-01

    A study was conducted on future prospects of FBR commercialization. Targets of further improving safety and economy were set to make commercial power plants that would be superior to future LWRs. Promising innovative technologies studied domestically and overseas were extracted by evaluating prospects for commercialization, effect, and plant applicability. Several commercial plants were conceptualized by introducing such technology to large-scale and oxide-fuel reactors. Estimates of construction cost, etc., proved that the targets could be achieved. A concept of long-term technological development was synthesized. (author)

  5. Stability-indicating liquid Chromatographic assaymethod for Opthalmic solutions containing combination of Dexamethasone and Chloramphenicol

    International Nuclear Information System (INIS)

    Rao, R.M.; Al-Ashban, R.M.; Shah, A.H.

    2004-01-01

    A selective high-performance chromatographic procedure for the stability monitoring of ophthalmic solutions containing a combination of dexamethasone and chloramphenicolis demonstrated. The separation of the active components and the degradation product of chloramphenicol (1-amino-1-(4-nitrophenyl)-propane-1, 3diol) was achieved on a u-Bondapack C-18 column ( 5 um, 300 mm x 3.9 mm) maintained at ambient temperature (15-20C) by utilizing a mobile phase consisting acidified water (5% actified water with glacial acetic acid ) : acetonitrile : triethyl amine 700 : 300 : 2and pH was adjusted to 5.0 by using 10 M Na OH. The flow rate was 1.5 ml min-1; and elutes were followed with UV-detection at 254 nm. Complete resolution of dexamethasone, chloramphenicol and its hydrolytic product could be attained. The sensitivity, accuracy and specificity were tested. The method was successfully applied in post-marketing stability of the commercial batches of ophthalmic solutions. (author)

  6. Surface properties and color stability of an acrylic resin combined with an antimicrobial polymer

    Directory of Open Access Journals (Sweden)

    Ana Carolina Pero

    Full Text Available INTRODUCTION: The occurrence of stomatitis is common since the surface characteristics of the dentures may act as reservoirs for microorganisms and have the potential to support biofilm formation. PURPOSE: To assess the surface properties (wettability/roughness and color stability of an acrylic resin combined with the antimicrobial polymer poly (2-tert-butylaminoethyl methacrylate (PTBAEMA. MATERIAL AND METHOD: Thirty disc-shaped specimens of an acrylic resin (Lucitone 550 were divided into three groups: 0% (control; 5% and 10% PTBAEMA. Surface roughness values (Ra were measured using a profilometer and wettability was determined through contact angle measurements using a goniometer and deionized water as a test liquid. Color data were measured with a spectrophotometer. Kruskal-Wallis and Dunn's test were used to compare roughness values. Wettability data were analyzed using ANOVA and Tukey's test. Color data were compared using the Student's t-test and ∆E values were classified according to the National Bureau of Standards (NBS. All statistical analyses were performed considering α=.05. RESULT: Significant differences (p<.05 were detected among the groups for roughness, wettability and color stability. According to the NBS, the color changes obtained in the 5% and 10% PTBAEMA groups were "appreciable" and "much appreciable", respectively. CONCLUSION: It could be concluded that PTBAEMA incorporation in an acrylic resin increased the roughness and wettability of surfaces and produced color changes with clinical relevance.

  7. Testing Single and Combinations of Amendments for Stabilization of Metals in Contrasting Extremely Contaminated Soils

    Directory of Open Access Journals (Sweden)

    Siebielec G.

    2013-04-01

    Full Text Available Metals can be stabilized by soil amendments that increase metals adsorption or alter their chemical forms. Such treatments may limit the risk related to the contamination through reduction of metal transfer to the food chain (reduction of metal uptake by plants and its availability to soil organisms and metals migration within the environment. There is a need for experiments comparing various soil amendments available at reasonable amounts under similar environmental conditions. The other question is whether all components of soil environment or soil functions are similarly protected after remediation treatment. We conducted a series of pot studies to test some traditional and novel amendments and their combinations. The treatments were tested for several highly Zn/Cd/Pb contaminated soils. Among traditional amendments composts were the most effective – they ensured plant growth, increased soil microbial activity, reduced Cd in earthworms, reduced Pb bioaccessibility and increased share of unavailable forms of Cd and Pb.

  8. Effects of antioxidant combinations on shelf stability of irradiated chicken sausage during storage

    Science.gov (United States)

    Hwang, Ko-Eun; Kim, Hyun-Wook; Song, Dong-Heon; Kim, Yong-Jae; Ham, Yun-Kyung; Lee, Ju-Woon; Choi, Yun-Sang; Kim, Cheon-Jei

    2015-01-01

    This study was conducted in order to investigate the combined effects of gamma irradiation (0, 2.5, and 5 kGy) and antioxidant combination, mugwort extract (ME) and ascorbic acid (Aa), on the pH, total color difference (ΔE), hue angle (H°), 2-thiobarbituricacid-reactive substances (TBARS) values, residual nitrite contents, and sensory evaluation in chicken sausage during storage. The pH values and sensory properties, except for color, of chicken sausage were not significantly affected by adding ME or treating irradiation during storage. However, ΔE, and H° values of samples containing ME (either alone or with Aa) were higher than that of control, whereas irradiation had no significant effect during storage. A combination of ME+Aa (0.2% ME+0.05% Aa) was effective at delaying lipid oxidation in irradiated chicken sausage. In addition, nitrite contents were reduced by gamma ray as a dose dependent manner and, particularly in ME+Aa was most effective in decreasing the residual nitrite. Our results suggested that gamma irradiation combined with an antioxidant mixture is a useful technology for reducing the residual nitrite and retarding the lipid oxidation in chicken sausage.

  9. Protein thermal stability enhancement by designing salt bridges: a combined computational and experimental study.

    Directory of Open Access Journals (Sweden)

    Chi-Wen Lee

    Full Text Available Protein thermal stability is an important factor considered in medical and industrial applications. Many structural characteristics related to protein thermal stability have been elucidated, and increasing salt bridges is considered as one of the most efficient strategies to increase protein thermal stability. However, the accurate simulation of salt bridges remains difficult. In this study, a novel method for salt-bridge design was proposed based on the statistical analysis of 10,556 surface salt bridges on 6,493 X-ray protein structures. These salt bridges were first categorized based on pairing residues, secondary structure locations, and Cα-Cα distances. Pairing preferences generalized from statistical analysis were used to construct a salt-bridge pair index and utilized in a weighted electrostatic attraction model to find the effective pairings for designing salt bridges. The model was also coupled with B-factor, weighted contact number, relative solvent accessibility, and conservation prescreening to determine the residues appropriate for the thermal adaptive design of salt bridges. According to our method, eight putative salt-bridges were designed on a mesophilic β-glucosidase and 24 variants were constructed to verify the predictions. Six putative salt-bridges leaded to the increase of the enzyme thermal stability. A significant increase in melting temperature of 8.8, 4.8, 3.7, 1.3, 1.2, and 0.7°C of the putative salt-bridges N437K-D49, E96R-D28, E96K-D28, S440K-E70, T231K-D388, and Q277E-D282 was detected, respectively. Reversing the polarity of T231K-D388 to T231D-D388K resulted in a further increase in melting temperatures by 3.6°C, which may be caused by the transformation of an intra-subunit electrostatic interaction into an inter-subunit one depending on the local environment. The combination of the thermostable variants (N437K, E96R, T231D and D388K generated a melting temperature increase of 15.7°C. Thus, this study

  10. Wastewater stabilization ponds - an appropriate technology for sewage treatment and refuse

    International Nuclear Information System (INIS)

    Aziz, J.A.

    1999-01-01

    Treatment of wastewater is imperative to protect human health and environmental quality. To this effect, the chosen technology should be cost effective, simple and easy to operate and maintain. Wastewater stabilization ponds offer one such technology and their use should be promoted in countries with scarcity of water so as to reuse the treated effluents in irrigation. Long term, pilot scale investigations on the performance of wastewater stabilization ponds have been undertaken at the Institute of Environmental Engineering and Research, Lahore to develop design criteria for their local use. This paper discuss the types and operation of waste stabilization ponds and the extent of their application in Pakistan. The need for users' education for effective operation of this simple facility is also emphasized. (author)

  11. Legality, separation of powers, stability of electoral law: The impact of new voting technologies

    OpenAIRE

    Driza Maurer, Ardita

    2016-01-01

    Legality, separation of powers and stability of electoral law are some of the principles of the European constitutional heritage. They should be respected and implemented throughout the electoral process, including when new voting technologies are used. This paper discusses e-voting specific implementations of the principles or challenges to it. Ongoing and proposed improvements in legislation or practice are pinpointed.

  12. Enhancing Economic Stability Utilizing the High Technologies in Community Colleges: A Case Study.

    Science.gov (United States)

    Mehnert, Barbara H.; Kurki, Allan W.

    Strategies to enhance the economic stability of community colleges through high technology approaches are discussed in this paper. First, general economic problems facing higher education are identified, and the ways in which they influence community colleges are described. Next, 10 strategies to aid in the economic recovery of community colleges…

  13. Development of sterilized porridge for patients by combined treatment of food technology with radiation technology

    International Nuclear Information System (INIS)

    Kim, Jaehun; Choi, Jongil; Song, Beomseok

    2010-09-01

    This research was conducted to develop patient foods of high quality using a radiation fusion technology with food processing. Radiation technique to increase calorie of porridge was established, and it was investigated that radiation effects on functional materials, which can could be added to increase functionality of patient foods. Moreover, sterilized semi-fluid meal (milk porridge) for patients with higher calorie was developed by a sterilization process by gamma irradiation, combined treatments to improve the sensory qualities, and fortification with various nutrients. Also, sensory survey on irradiated commercial patient foods was performed to find the problems and improvement points of the developed products. Optimal packaging material was selected by evaluation of effect of irradiation in packaging materials and a convenient package for consuming by patients was decided. Safety of the irradiated milk porridge was confirmed by in-vivo genotoxicological test, and its nutritional composition for patients was evaluated by nutritional analysis. Finally, the milk porridge was developed as liquid, dried, powdered, and pellet type products. This research may contribute to improve life quality of patients by supplement of various foods with high quality to immuno-compromised patients. Furthermore, economic profits and technological advances are expected by commercialization of the patient foods

  14. Development of sterilized porridge for patients by combined treatment of food technology with radiation technology

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jaehun; Choi, Jongil; Song, Beomseok; and others

    2010-09-15

    This research was conducted to develop patient foods of high quality using a radiation fusion technology with food processing. Radiation technique to increase calorie of porridge was established, and it was investigated that radiation effects on functional materials, which can could be added to increase functionality of patient foods. Moreover, sterilized semi-fluid meal (milk porridge) for patients with higher calorie was developed by a sterilization process by gamma irradiation, combined treatments to improve the sensory qualities, and fortification with various nutrients. Also, sensory survey on irradiated commercial patient foods was performed to find the problems and improvement points of the developed products. Optimal packaging material was selected by evaluation of effect of irradiation in packaging materials and a convenient package for consuming by patients was decided. Safety of the irradiated milk porridge was confirmed by in-vivo genotoxicological test, and its nutritional composition for patients was evaluated by nutritional analysis. Finally, the milk porridge was developed as liquid, dried, powdered, and pellet type products. This research may contribute to improve life quality of patients by supplement of various foods with high quality to immuno-compromised patients. Furthermore, economic profits and technological advances are expected by commercialization of the patient foods.

  15. Combined cycle power plants: technological prospects for improving the efficiency

    International Nuclear Information System (INIS)

    Lauri, R.

    2009-01-01

    The combined cycle power plants characteristics are better than one course open to a closed loop presenting an electrical efficiency close to 60% do not reach for gas turbine engines for power plants and conventional steam engines. [it

  16. Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions

    Directory of Open Access Journals (Sweden)

    Yusuf Mohammed

    2011-12-01

    Full Text Available Abstract Background Physical mapping of transgenic insertions by Fluorescence in situ Hybridization (FISH is a reliable and cost-effective technique. Chromosomal assignment is commonly achieved either by concurrent G-banding or by a multi-color FISH approach consisting of iteratively co-hybridizing the transgenic sequence of interest with one or more chromosome-specific probes at a time, until the location of the transgenic insertion is identified. Results Here we report a technical development for fast chromosomal assignment of transgenic insertions at the single cell level in mouse and rat models. This comprises a simplified 'single denaturation mixed hybridization' procedure that combines multi-color karyotyping by Multiplex FISH (M-FISH, for simultaneous and unambiguous identification of all chromosomes at once, and the use of a Quantum Dot (QD conjugate for the transgene detection. Conclusions Although the exploitation of the unique optical properties of QD nanocrystals, such as photo-stability and brightness, to improve FISH performance generally has been previously investigated, to our knowledge this is the first report of a purpose-designed molecular cytogenetic protocol in which the combined use of QDs and standard organic fluorophores is specifically tailored to assist gene transfer technology.

  17. The Stability of New Single-Layer Combined Lattice Shell Based on Aluminum Alloy Honeycomb Panels

    Directory of Open Access Journals (Sweden)

    Caiqi Zhao

    2017-11-01

    Full Text Available This article proposes a new type of single-layer combined lattice shell (NSCLS; which is based on aluminum alloy honeycomb panels. Six models with initial geometric defect were designed and precision made using numerical control equipment. The stability of these models was tested. The results showed that the stable bearing capacity of NSCLS was approximately 16% higher than that of a lattice shell with the same span without a reinforcing plate. At the same time; the properties of the NSCLS were sensitive to defects. When defects were present; its stable bearing capacity was decreased by 12.3% when compared with the defect-free model. The model with random defects following a truncated Gaussian distribution could be used to simulate the distribution of defects in the NSCLS. The average difference between the results of the nonlinear analysis and the experimental results was 5.7%. By calculating and analyzing nearly 20,000 NSCLS; the suggested values of initial geometric defect were presented. The results of this paper could provide a theoretical basis for making and revising the design codes for this new combined lattice shell structure.

  18. Combined heterogeneous Electro-Fenton and biological process for the treatment of stabilized landfill leachate.

    Science.gov (United States)

    Baiju, Archa; Gandhimathi, R; Ramesh, S T; Nidheesh, P V

    2018-03-15

    Treatment of stabilized landfill leachate is a great challenge due to its poor biodegradability. Present study made an attempt to treat this wastewater by combining electro-Fenton (E-Fenton) and biological process. E-Fenton treatment was applied prior to biological process to enhance the biodegradability of leachate, which will be beneficial for the subsequent biological process. This study also investigates the efficiency of iron molybdophosphate (FeMoPO) nanoparticles as a heterogeneous catalyst in E-Fenton process. The effects of initial pH, catalyst dosage, applied voltage and electrode spacing on Chemical Oxygen Demand (COD) removal efficiency were analyzed to determine the optimum conditions. Heterogeneous E-Fenton process gave 82% COD removal at pH 2, catalyst dosage of 50 mg/L, voltage 5 V, electrode spacing 3 cm and electrode area 25 cm 2 . Combined E-Fenton and biological treatment resulted an overall COD removal of 97%, bringing down the final COD to 192 mg/L. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Attempts to increase storage stability of strawberry yoghurt by combination treatments

    International Nuclear Information System (INIS)

    Kiss, I.

    1975-01-01

    The aim of the experiments was to establish whether the microbiological stability of strawberry yoghurt might be improved by decreasing the microbial load of the fruit. The effect of heat treatment, freezing, irradiation and various combinations of these treatments upon cell count and sensory quality was investigated. It was established that none of the individual treatments was entirely satisfactory. Surfacial heat treatment at 55 0 C, freezing and irradiation with 0.4-0.6 Mrad substantially increased the storage life of strawberries or that of the yoghurt prepared with this fruit; when compared to yoghurt made with frozen strawberries by the dairy factory, the increase was 2.5 fold at 15 0 C and 3.5 fold at 2 0 C. The relative increase of storage life was lower at lower yeast-cell counts. The strawberries irradiated with doses above 0.2 Mrad showed aroma and flavour changes immediately upon treatment. This effect, however, was eliminated after some days. The yoghurt made with strawberries given a radiation treatment of 0.57 Mrad did not differ organoleptically from the yoghurt made with untreated strawberries. In the knowledge of the survival rate of yeasts after irradiation the D 10 values were established. These were found in the dose range between 0.043 and 0.087 Mrad. It was established that the applied heat treatment, freezing and irradiation at these dose levels and at 10 3 -10 4 cells per gram were not sufficient from the point of view of microbiological stability. (F.J.)

  20. The research of a gyro-stabilized platform and POS application technology in airborne remote sensing

    Science.gov (United States)

    Xu, Jiang; Du, Qi

    2009-07-01

    The distortion of the collected images usually takes place since the attitude changes along with the flying aerocraft on airborne remote sensing. In order to get original images without distortion, it is necessary to use professional gyro-stabilized platform. In addition to this, another solution of correcting the original image distortion is to utilize later geometric rectification using position & orientation system ( POS ) data. The third way is to utilize medium-accuracy stabilized platform to control the distortion at a tolerant range, and then make use of the data obtained by high-solution posture measure system to correct the low-quality remote sensing images. The third way which takes advantage of both techniques is better than using only one of the two other ways. This paper introduces several kinds of structural forms of gyro-stabilized platforms, and POS acquiring instruments respectively. Then, the essay will make some analysis of their advantages and disadvantages, key technologies and the application experiment of the third method. After the analysis, the thesis discusses the design of the gyro-stabilized platform. The thesis provides crucial information not only for the application technology of gyro-stabilized platform and POS but also for future development.

  1. Seamless Guidance System Combining GPS, BLE Beacon, and NFC Technologies

    Directory of Open Access Journals (Sweden)

    Rung-Shiang Cheng

    2016-01-01

    Full Text Available Users rely increasingly on Location-Based Services (LBS and automated navigation/guidance systems nowadays. However, while such services are easily implemented in outdoor environments using Global Positioning System (GPS technology, a requirement still exists for accurate localization and guidance schemes in indoor settings. Accordingly, the present study proposes a system based on GPS, Bluetooth Low Energy (BLE beacons, and Near Field Communication (NFC technology. Through establishing graphic information and the design of algorithm, this study develops a guidance system for indoors and outdoors on smart phones, wishing to give user perfect smart life through this system. The proposed system is implemented on a smart phone and evaluated on a student campus environment. The experimental results confirm the ability of the proposed app to switch automatically from an outdoor mode to an indoor mode and to guide the user to requested target destination via the shortest possible route.

  2. Combination of sodium caseinate and succinylated alginate improved stability of high fat fish oil-in-water emulsions.

    Science.gov (United States)

    Yesiltas, Betül; Sørensen, Ann-Dorit Moltke; García-Moreno, Pedro J; Anankanbil, Sampson; Guo, Zheng; Jacobsen, Charlotte

    2018-07-30

    Sodium caseinate (CAS) and commercial sodium alginate (CA), long chain modified alginate (LCMA) or short chain modified alginate (SCMA) were used in combination for emulsifying and stabilizing high fat (50-70%) fish oil-in-water emulsions. Physical (creaming, droplet size, viscosity and protein determination) and oxidative (primary and secondary oxidation products) stabilities of the emulsions were studied during 12 days of storage. Creaming stability was higher for emulsions produced with alginates and CAS compared to emulsions prepared with only CAS. Combined use of CAS + LCMA performed better in terms of physical stability compared to emulsions produced with only CAS. However, the oxidative stability of this emulsion was inferior probably due to the presence of an unsaturated carbon chain in LCMA structure. CAS + SCMA emulsions not only showed better physical stability such as smaller droplet size, lower creaming and higher viscosity, but also had an improved oxidative stability than emulsions produced with only CAS. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. Stability of a sweet product of tamarillo (Cyphomandra betacea preserved by combined methods

    Directory of Open Access Journals (Sweden)

    Villegas-Ruíz Xadeni

    2013-06-01

    Full Text Available The aim of this study was the use of the hurdle technology for preparing a sweet product (SPT of tamarillo (Cyphomandra betacea and assess its storage stability. SPT was prepared at the fruit natural pH (3.72, lowering the water activity (aw (0.901 by adding sucrose and sodium benzoate (0.1% as antimicrobial. SPT was stored under refrigeration (4 °C conditions protected from light and it was analyzed every third day for 60 days. Physicochemical (color, aw, pH, and titratable acidity as citric acid, antioxidant (antioxidant capacity, total phenolics, and anthocyanins, and microbiological (aerobic mesophilic bacteria, molds, and yeasts, were determined. SPT was mixed with plain yogurt to evaluate the overall sensory acceptance during storage. The evaluation took place every seventh day during 49 days. The storage time had no effect neither on aw, pH or acidity of the SPT. It was observed an increase in the net change of color (0 to 4.9 and a decrease in total phenolic compounds (1.213-0.816 mg gallic acid/g SPT, total monomeric anthocyanins (0.910-0.611 mg cyanidin-3-glucoside/g SPT g, and antioxidant capacity (5.816-3.576 µmole Trolox/g SPT. The aerobic mesophilic bacteria ( 0.05 during storage.

  4. Combining internet technology and mobile phones for emergency response management

    International Nuclear Information System (INIS)

    Palsson, S.E.

    2002-12-01

    The report is intended for persons involved in radiological emergency response management. An introduction is given to the technical basis of the mobile Internet and ongoing development summarised. Examples are given describing how mobile Internet technology has been used to improve monitoring media coverage of incidents and events, and a test is described where web based information was selectively processed and made available to WAP enabled mobile phones. The report concludes with recommendations stressing the need for following mobile Internet developments and taking them into account when designing web applications for radiological response management. Doing so can make web based material accessible to mobile devices at minimal additional cost. (au)

  5. Technological innovation and valorisation of traditional food: a sustainable combination?

    Directory of Open Access Journals (Sweden)

    Marco Dalla Rosa

    2009-10-01

    Full Text Available Valorization of traditional foods is nowadays a key element for market developments where national industries are strongly involved in saving product peculiarity against imitative food coming from foreign countries or even different continents. Other than the lack in well defined and garanteed sensorial quality, the production conditions, the quality of raw material and the different cultural background lead to produce foods that, despite to the name indicating some italian origin or recallin in some ways Italy and italian food and traditions, are only imitation without safety and quality proper of the original traditional food. Thus it is necessary to individuate appropriated technologies and strategies to increase le level of garantee offered to the consumer in order to promote the consumption of traditional foods with the promised quality and safety. In this paper the role that the modern food technology and the food science can assume to improve the processing conditions and yields, introducing some innovations into the old processes will be pointed out. Furthermore, the characterization of the complexity of the chemical, chemico-physical and rheological properties that influence the whole sensorial aspect of traditional foods, both from animal and vegetal (and fruit origin, is a growing challenge of the food science since the new analytical methodologies now available. In the paper some example of objective characterization and introduction of innovation steps are reported as well as genuinity marker individuation in order to give sustainability to the production of traditional foods in particular in SME.

  6. Dynamics of fault slip near the stability transition combining laboratory and numerical experiments

    Science.gov (United States)

    Mele Veedu, D.; Giorgetti, C.; Scuderi, M. M.; Barbot, S.; Marone, C.; Collettini, C.

    2017-12-01

    Frictional stability controls the seismogenic potential of faults. Laboratory (1) and theoretical (2) studies document and predict the conditions under which fault slip is seismic or aseismic. However, the full gamut of fault slip behavior near the stable/unstable boundary is still poorly known. Here, we combine insight from laboratory and numerical experiments to identify the wide spectrum of frictional instabilities around that transition, including slow-slip events, period-multiplying events, and chaos. We present a synoptic picture of the dynamics of fault slip in a bifurcation diagram obtained from a series of laboratory and numerical experiments. We compare the laboratory observations with spring-slider and finite-fault numerical models. In the laboratory, we vary the stiffness of the system by modulating the stress field around the experimental fault. In the numerical experiments, we vary the characteristic weakening distance to explore a range of critical nucleation sizes. Contrarily to previously found (3), complex fault dynamics can be obtained with a rate-and-state constitutive law with a single state variable. While the dynamics of fault slip is complicated on large faults by the presence of morphological and rheological heterogeneities, the range of instabilities identified in the laboratory is reminiscent of the variety of slow and fast earthquakes found along subduction zones (4). The accord between laboratory data and theoretical models affords more realistic predictions of fault behavior at slow slip speeds. (1) Scuderi et al., (2016), (2) Ruina (1983), (3) Gu & Wong (1994), (4) Obara & Kato (2016)

  7. Biochar affects carbon composition and stability in soil: a combined spectroscopy-microscopy study

    Science.gov (United States)

    Hernandez-Soriano, Maria C.; Kerré, Bart; Kopittke, Peter M.; Horemans, Benjamin; Smolders, Erik

    2016-01-01

    The use of biochar can contribute to carbon (C) storage in soil. Upon addition of biochar, there is a spatial reorganization of C within soil particles, but the mechanisms remain unclear. Here, we used Fourier transformed infrared-microscopy and confocal laser scanning microscopy to examine this reorganization. A silty-loam soil was amended with three different organic residues and with the biochar produced from these residues and incubated for 237 d. Soil respiration was lower in biochar-amended soils than in residue-amended soils. Fluorescence analysis of the dissolved organic matter revealed that biochar application increased a humic-like fluorescent component, likely associated with biochar-C in solution. The combined spectroscopy-microscopy approach revealed the accumulation of aromatic-C in discrete spots in the solid-phase of microaggregates and its co-localization with clay minerals for soil amended with raw residue or biochar.The co-localization of aromatic-C:polysaccharides-C was consistently reduced upon biochar application. We conclude that reduced C metabolism is an important mechanism for C stabilization in biochar-amended soils. PMID:27113269

  8. Biochar affects carbon composition and stability in soil: a combined spectroscopy-microscopy study

    Science.gov (United States)

    Hernandez-Soriano, Maria C.; Kerré, Bart; Kopittke, Peter M.; Horemans, Benjamin; Smolders, Erik

    2016-04-01

    The use of biochar can contribute to carbon (C) storage in soil. Upon addition of biochar, there is a spatial reorganization of C within soil particles, but the mechanisms remain unclear. Here, we used Fourier transformed infrared-microscopy and confocal laser scanning microscopy to examine this reorganization. A silty-loam soil was amended with three different organic residues and with the biochar produced from these residues and incubated for 237 d. Soil respiration was lower in biochar-amended soils than in residue-amended soils. Fluorescence analysis of the dissolved organic matter revealed that biochar application increased a humic-like fluorescent component, likely associated with biochar-C in solution. The combined spectroscopy-microscopy approach revealed the accumulation of aromatic-C in discrete spots in the solid-phase of microaggregates and its co-localization with clay minerals for soil amended with raw residue or biochar.The co-localization of aromatic-C:polysaccharides-C was consistently reduced upon biochar application. We conclude that reduced C metabolism is an important mechanism for C stabilization in biochar-amended soils.

  9. Application of FBG Sensing Technology in Stability Analysis of Geogrid-Reinforced Slope.

    Science.gov (United States)

    Sun, Yijie; Xu, Hongzhong; Gu, Peng; Hu, Wenjie

    2017-03-15

    By installing FBG sensors on the geogrids, smart geogrids can both reinforce and monitor the stability for geogrid-reinforced slopes. In this paper, a geogrid-reinforced sand slope model test is conducted in the laboratory and fiber Bragg grating (FBG) sensing technology is used to measure the strain distribution of the geogrid. Based on the model test, the performance of the reinforced soil slope is simulated by finite element software Midas-GTS, and the stability of the reinforced soil slope is analyzed by strength reduction method. The relationship between the geogrid strain and the factor of safety is set up. The results indicate that the measured strain and calculated results agree very well. The geogrid strain measured by FBG sensor can be applied to evaluate the stability of geogrid-reinforced sand slopes.

  10. Emulsion stability measurements by single electrode capacitance probe (SeCaP) technology

    International Nuclear Information System (INIS)

    Schüller, R B; Løkra, S; Egelandsdal, B; Salas-Bringas, C; Engebretsen, B

    2008-01-01

    This paper describes a new and novel method for the determination of the stability of emulsions. The method is based on the single electrode capacitance technology (SeCaP). A measuring system consisting of eight individual measuring cells, each with a volume of approximately 10 ml, is described in detail. The system has been tested on an emulsion system based on whey proteins (WPC80), oil and water. Xanthan was added to modify the emulsion stability. The results show that the new measuring system is able to quantify the stability of the emulsion in terms of a differential variable. The whole separation process is observed much faster in the SeCaP system than in a conventional separation column. The complete separation process observed visually over 30 h is seen in less than 1.4 h in the SeCaP system

  11. Combining innovative technology demonstrations with dense nonaqueous phase liquids cleanup

    International Nuclear Information System (INIS)

    Hagood, M.C.; Koegler, K.J.; Rohay, V.J.; Trent, S.J.; Stein, S.L.; Brouns, T.M.; McCabe, G.H.; Tomich, S.

    1993-05-01

    Radioactively contaminated acidic aqueous wastes and organic liquids were discharged to the soil column at three disposal sites within the 200 West Area of the Hanford Site, Washington. As a result, a portion of the underlying groundwater is contaminated with carbon tetrachloride several orders of magnitude above the maximum contaminant level accepted for a drinking water supply. Treatability testing and cleanup actions have been initiated to remove the contamination from both the unsaturated soils to minimize further groundwater contamination and the groundwater itself. To expedite cleanup, innovative technologies for (1) drilling, (2) site characterization, (3) monitoring, (4) well field development, and (5) contaminant treatment are being demonstrated and subsequently used where possible to improve the rates and cost savings associated with the removal of carbon tetrachloride from the soils and groundwater

  12. Technology Combination Analysis Tool (TCAT) for Active Debris Removal

    Science.gov (United States)

    Chamot, B.; Richard, M.; Salmon, T.; Pisseloup, A.; Cougnet, C.; Axthelm, R.; Saunder, C.; Dupont, C.; Lequette, L.

    2013-08-01

    This paper present the work of the Swiss Space Center EPFL within the CNES-funded OTV-2 study. In order to find the most performant Active Debris Removal (ADR) mission architectures and technologies, a tool was developed in order to design and compare ADR spacecraft, and to plan ADR campaigns to remove large debris. Two types of architectures are considered to be efficient: the Chaser (single-debris spacecraft), the Mothership/ Kits (multiple-debris spacecraft). Both are able to perform controlled re-entry. The tool includes modules to optimise the launch dates and the order of capture, to design missions and spacecraft, and to select launch vehicles. The propulsion, power and structure subsystems are sized by the tool thanks to high-level parametric models whilst the other ones are defined by their mass and power consumption. Final results are still under investigation by the consortium but two concrete examples of the tool's outputs are presented in the paper.

  13. Searching to combine technologies for safer food attainment

    Directory of Open Access Journals (Sweden)

    Lucilla Imbroinise Azeredo Caruso

    2011-06-01

    Full Text Available Campylobacteriosis is an infection frequently acquired through the consumption of animal origin products. Chicken can be considered the main responsible cause in the transmission chain of this disease. Ionizing radiation was used to verify the reduction of the microbiological load of Campylobacter jejuni present in chicken liver, which, in natura, can present contamination in up to 100% of the cases. The doses of irradiation used were: 0.20 kGy, 0.27 kGy, 0.30 kGy and 0.35 kGy. The samples of chicken liver were acquired in aviaries, local supermarkets and large chain supermarkets. The samples were analyzed for Campylobacter at FIOCRUZ. Irradiation was performed at COPPE/UFRJ, using a Gamma Cell Irradiator with a 60Co gamma source. Only the frozen sample acquired at the local supermarket did not contain the bacterium. Campylobacter sp. was present in all other samples, even when using procedures and technologies that aimed at the impediment of the presence of this bacterium in food and, consequently, at the protection of human health. On the whole, the results were satisfactory; nevertheless, it is known that the bacterial growth conditions required by this bacterium are uncommon when compared to other enteropathogenic bacteria.

  14. Moment Lyapunov Exponent and Stochastic Stability of Binary Airfoil under Combined Harmonic and Non-Gaussian Colored Noise Excitations

    Science.gov (United States)

    Hu, D. L.; Liu, X. B.

    Both periodic loading and random forces commonly co-exist in real engineering applications. However, the dynamic behavior, especially dynamic stability of systems under parametric periodic and random excitations has been reported little in the literature. In this study, the moment Lyapunov exponent and stochastic stability of binary airfoil under combined harmonic and non-Gaussian colored noise excitations are investigated. The noise is simplified to an Ornstein-Uhlenbeck process by applying the path-integral method. Via the singular perturbation method, the second-order expansions of the moment Lyapunov exponent are obtained, which agree well with the results obtained by the Monte Carlo simulation. Finally, the effects of the noise and parametric resonance (such as subharmonic resonance and combination additive resonance) on the stochastic stability of the binary airfoil system are discussed.

  15. Combination of sodium caseinate and succinylated alginate improved stability of high fat fish oil-in-water emulsions

    DEFF Research Database (Denmark)

    Yesiltas, Betül; Sørensen, Ann-Dorit Moltke; García Moreno, Pedro Jesús

    2018-01-01

    Sodium caseinate (CAS) and commercial sodium alginate (CA), long chain modified alginate (LCMA) or short chain modified alginate (SCMA) were used in combination for emulsifying and stabilizing high fat (50–70%) fish oil-in-water emulsions. Physical (creaming, droplet size, viscosity and protein...

  16. The effect of CMC and arabic gum stabilizer combination on the characteristics of soursop velva (Annona muricata L.)

    Science.gov (United States)

    Parnanto, N. H. R.; Yudhistira, B.; Pertiwi, S. R.; Pangestika, A.

    2018-03-01

    The aims of this study were to determine the effect of the combination of CMC and Arabic Gum stabilizer toward the soursop velva characteristics and to determine the best stabilizer combination of soursop velva. This study was performed using Completely Randomized Design (CRD) with one factor: combination of CMC and Arabic Gum stabilizer using two sample replications and the analysis was repeated three times. The result showed that the use of the combination of CMC and Arabic Gum stabilizer gave a significant effect on the overrun value, melting power, total dissolved solids, moisture content, dietary fiber, taste, texture and overalls. Moreover, there were no significant effect on color and flavor of the soursop velva. The experiment showed that soursop velva F4 (3:1) was the best formula with overrun value 9.93%, the melting power was 22 minutes 52 seconds, the total dissolved solids 19,10°Brix, the moisture content 71.508%, dietary fiber 3.301% and it has sensory values of color, taste, flavor, texture, overall at 3.66, 3.267, 3.33, 4.06, 3.10 respectively.

  17. Technology of high-speed combined machining with brush electrode

    Science.gov (United States)

    Kirillov, O. N.; Smolentsev, V. P.; Yukhnevich, S. S.

    2018-03-01

    The new method was proposed for high-precision dimensional machining with a brush electrode when the true position of bundles of metal wire is adjusted by means of creating controlled centrifugal forces appeared due to the increased frequency of rotation of a tool. There are the ultimate values of circumferential velocity at which the bundles are pressed against a machined area of a workpiece in a stable manner despite the profile of the machined surface and variable stock of the workpiece. The special aspects of design of processing procedures for finishing standard parts, including components of products with low rigidity, are disclosed. The methodology of calculation and selection of processing modes which allow one to produce high-precision details and to provide corresponding surface roughness required to perform finishing operations (including the preparation of a surface for metal deposition) is presented. The production experience concerned with the use of high-speed combined machining with an unshaped tool electrode in knowledge-intensive branches of the machine-building industry for different types of production is analyzed. It is shown that the implementation of high-speed dimensional machining with an unshaped brush electrode allows one to expand the field of use of the considered process due to the application of a multipurpose tool in the form of a metal brush, as well as to obtain stable results of finishing and to provide the opportunities for long-term operation of the equipment without its changeover and readjustment.

  18. Physical and chemical stability of expired fixed dose combination artemether-lumefantrine in uncontrolled tropical conditions

    Directory of Open Access Journals (Sweden)

    Hess Kimberly

    2009-02-01

    Full Text Available Abstract Background New artemisinin combination therapies pose difficulties of implementation in developing and tropical settings because they have a short shelf-life (two years relative to the medicines they replace. This limits the reliability and cost of treatment, and the acceptability of this treatment to health care workers. A multi-pronged investigation was made into the chemical and physical stability of fixed dose combination artemether-lumefantrine (FDC-ALU stored under heterogeneous, uncontrolled African conditions, to probe if a shelf-life extension might be possible. Methods Seventy samples of expired FDC-ALU were collected from private pharmacies and malaria researchers in seven African countries. The samples were subjected to thin-layer chromatography (TLC, disintegration testing, and near infrared Raman spectrometry for ascertainment of active ingredients, tablet integrity, and chemical degradation of the tablet formulation including both active ingredients and excipients. Results Seventy samples of FDC-ALU were tested in July 2008, between one and 58 months post-expiry. 68 of 70 (97% samples passed TLC, disintegration and Raman spectrometry testing, including eight samples that were post-expiry by 20 months or longer. A weak linear association (R2 = 0.33 was observed between the age of samples and their state of degradation relative to brand-identical samples on Raman spectrometry. Sixty-eight samples were retested in February 2009 using Raman spectrometry, between eight and 65 months post-expiry. 66 of 68 (97% samples passed Raman spectrometry retesting. An unexpected observation about African drug logistics was made in three batches of FDC-ALU, which had been sold into the public sector at concessional pricing in accordance with a World Health Organization (WHO agreement, and which were illegally diverted to the private sector where they were sold for profit. Conclusion The data indicate that FDC-ALU is chemically and

  19. Combined effects of climate change and bank stabilization on shallow water habitats of chinook salmon.

    Science.gov (United States)

    Jorgensen, Jeffrey C; McClure, Michelle M; Sheer, Mindi B; Munn, Nancy L

    2013-12-01

    Significant challenges remain in the ability to estimate habitat change under the combined effects of natural variability, climate change, and human activity. We examined anticipated effects on shallow water over low-sloped beaches to these combined effects in the lower Willamette River, Oregon, an area highly altered by development. A proposal to stabilize some shoreline with large rocks (riprap) would alter shallow water areas, an important habitat for threatened Chinook salmon (Oncorhynchus tshawytscha), and would be subject to U.S. Endangered Species Act-mandated oversight. In the mainstem, subyearling Chinook salmon appear to preferentially occupy these areas, which fluctuate with river stages. We estimated effects with a geospatial model and projections of future river flows. Recent (1999-2009) median river stages during peak subyearling occupancy (April-June) maximized beach shallow water area in the lower mainstem. Upstream shallow water area was maximized at lower river stages than have occurred recently. Higher river stages in April-June, resulting from increased flows predicted for the 2080s, decreased beach shallow water area 17-32%. On the basis of projected 2080s flows, more than 15% of beach shallow water area was displaced by the riprap. Beach shallow water area lost to riprap represented up to 1.6% of the total from the mouth to 12.9 km upstream. Reductions in shallow water area could restrict salmon feeding, resting, and refuge from predators and potentially reduce opportunities for the expression of the full range of life-history strategies. Although climate change analyses provided useful information, detailed analyses are prohibitive at the project scale for the multitude of small projects reviewed annually. The benefits of our approach to resource managers include a wider geographic context for reviewing similar small projects in concert with climate change, an approach to analyze cumulative effects of similar actions, and estimation of the

  20. Stabilization

    Directory of Open Access Journals (Sweden)

    Muhammad H. Al-Malack

    2016-07-01

    Full Text Available Fuel oil flyash (FFA produced in power and water desalination plants firing crude oils in the Kingdom of Saudi Arabia is being disposed in landfills, which increases the burden on the environment, therefore, FFA utilization must be encouraged. In the current research, the effect of adding FFA on the engineering properties of two indigenous soils, namely sand and marl, was investigated. FFA was added at concentrations of 5%, 10% and 15% to both soils with and without the addition of Portland cement. Mixtures of the stabilized soils were thoroughly evaluated using compaction, California Bearing Ratio (CBR, unconfined compressive strength (USC and durability tests. Results of these tests indicated that stabilized sand mixtures could not attain the ACI strength requirements. However, marl was found to satisfy the ACI strength requirement when only 5% of FFA was added together with 5% of cement. When the FFA was increased to 10% and 15%, the mixture’s strength was found to decrease to values below the ACI requirements. Results of the Toxicity Characteristics Leaching Procedure (TCLP, which was performed on samples that passed the ACI requirements, indicated that FFA must be cautiously used in soil stabilization.

  1. Identification of long-term containment/stabilization technology performance issues

    International Nuclear Information System (INIS)

    Matthern, G.E.; Nickelson, D.F.

    1997-01-01

    U.S. Department of Energy (DOE) faces a somewhat unique challenge when addressing in situ remedial alternatives that leave long-lived radionuclides and hazardous contaminants onsite. These contaminants will remain a potential hazard for thousands of years. However, the risks, costs, and uncertainties associated with removal and offsite disposal are leading many sites to select in situ disposal alternatives. Improvements in containment, stabilization, and monitoring technologies will enhance the viability of such alternatives for implementation. DOE's Office of Science and Technology sponsored a two day workshop designed to investigate issues associated with the long-term in situ stabilization and containment of buried, long-lived hazardous and radioactive contaminants. The workshop facilitated communication among end users representing most sites within the DOE, regulators, and technologists to define long-term performance issues for in situ stabilization and containment alternatives. Participants were divided into groups to identify issues and a strategy to address priority issues. This paper presents the results of the working groups and summarizes the conclusions. A common issue identified by the work groups is communication. Effective communication between technologists, risk assessors, end users, regulators, and other stakeholders would contribute greatly to resolution of both technical and programmatic issues

  2. Improved Stability of Tuberculosis Drug Fixed-Dose Combination Using Isoniazid-Caffeic Acid and Vanillic Acid Cocrystal.

    Science.gov (United States)

    Battini, Swapna; Mannava, M K Chaitanya; Nangia, Ashwini

    2018-06-01

    The classic fixed-dose combination (FDC) of 4 tuberculosis drugs, namely rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), and ethambutol dihydrochloride (EDH) has the twin issues of physical stability and RIF cross-reaction in the 4-FDC. The major reason for these quality issues is the interaction between RIF and INH to yield isonicotinyl hydrazone in drug tablets. Pharmaceutical cocrystals of INH with caffeic acid (CFA) (PZA + EDH + RIF + INH-CFA cocrystal) and vanillic acid (VLA) (PZA + EDH + RIF + INH-VLA cocrystal) are able to stabilize the FDC formulation compared with the reference batch (PZA + EDH + RIF + INH). Stability studies under accelerated humidity and temperature stress conditions of 40°C and 75% relative humidity showed that the physical stability of the cocrystal formulation was superior by powder X-ray diffraction and scanning electron microscopy analysis, and chemical purity was analyzed by high-performance liquid chromatography. Changes in the composition and structure were monitored on samples drawn at 7, 15, 22, and 30 days of storage. FDC-INH-CFA cocrystal batch exhibited greater stability compared with FDC-INH-VLA cocrystal and FDC reference drug batches. The superior stability of INH-CFA cocrystal is attributed to the presence of stronger hydrogen bonds and cyclic O-H⋯O synthon in the crystal structure. Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  3. Stabilized helical peptides: overview of the technologies and its impact on drug discovery.

    Science.gov (United States)

    Klein, Mark

    2017-11-01

    Protein-protein interactions are predominant in the workings of all cells. Until now, there have been a few successes in targeting protein-protein interactions with small molecules. Peptides may overcome some of the challenges of small molecules in disrupting protein-protein interactions. However, peptides present a new set of challenges in drug discovery. Thus, the study of the stabilization of helical peptides has been extensive. Areas covered: Several technological approaches to helical peptide stabilization have been studied. In this review, stapled peptides, foldamers, and hydrogen bond surrogates are discussed. Issues regarding design principles are also discussed. Furthermore, this review introduces select computational techniques used to aid peptide design and discusses clinical trials of peptides in a more advanced stage of development. Expert opinion: Stabilized helical peptides hold great promise in a wide array of diseases. However, the field is still relatively new and new design principles are emerging. The possibilities of peptide modification are quite extensive and expanding, so the design of stabilized peptides requires great attention to detail in order to avoid a large number of failed lead peptides. The start of clinical trials with stapled peptides is a promising sign for the future.

  4. Combining technologies to create bioactive hybrid scaffolds for bone tissue engineering

    NARCIS (Netherlands)

    Nandakumar, A.; Barradas, A.M.C.; de Boer, Jan; Moroni, Lorenzo; van Blitterswijk, Clemens; Habibovic, Pamela

    2013-01-01

    Combining technologies to engineer scaffolds that can offer physical and chemical cues to cells is an attractive approach in tissue engineering and regenerative medicine. In this study, we have fabricated polymer-ceramic hybrid scaffolds for bone regeneration by combining rapid prototyping (RP),

  5. Economic comparison of clean coal generating technologies with natural gas-combined cycle systems

    International Nuclear Information System (INIS)

    Sebesta, J.J.; Hoskins, W.W.

    1990-01-01

    This paper reports that there are four combustion technologies upon which U.S. electric utilities are expected to rely for the majority of their future power generating needs. These technologies are pulverized coal- fired combustion (PC); coal-fired fluidized bed combustion (AFBC); coal gasification, combined cycle systems (CGCC); and natural gas-fired combined cycle systems (NGCC). The engineering and economic parameters which affect the choice of a technology include capital costs, operating and maintenance costs, fuel costs, construction schedule, process risk, environmental and site impacts, fuel efficiency and flexibility, plant availability, capacity factors, timing of startup, and the importance of utility economic and financial factors

  6. Generating power at high efficiency combined cycle technology for sustainable energy production

    CERN Document Server

    Jeffs, E

    2008-01-01

    Combined cycle technology is used to generate power at one of the highest levels of efficiency of conventional power plants. It does this through primary generation from a gas turbine coupled with secondary generation from a steam turbine powered by primary exhaust heat. Generating power at high efficiency thoroughly charts the development and implementation of this technology in power plants and looks to the future of the technology, noting the advantages of the most important technical features - including gas turbines, steam generator, combined heat and power and integrated gasification com

  7. Combined influence of inertia, gravity, and surface tension on the linear stability of Newtonian fiber spinning

    Science.gov (United States)

    Bechert, M.; Scheid, B.

    2017-11-01

    The draw resonance effect appears in fiber spinning processes if the ratio of take-up to inlet velocity, the so-called draw ratio, exceeds a critical value and manifests itself in steady oscillations of flow velocity and fiber diameter. We study the effect of surface tension on the draw resonance behavior of Newtonian fiber spinning in the presence of inertia and gravity. Utilizing an alternative scaling makes it possible to visualize the results in stability maps of highly practical relevance. The interplay of the destabilizing effect of surface tension and the stabilizing effects of inertia and gravity lead to nonmonotonic stability behavior and local stability maxima with respect to the dimensionless fluidity and the dimensionless inlet velocity. A region of unconditional instability caused by the influence of surface tension is found in addition to the region of unconditional stability caused by inertia, which was described in previous works [M. Bechert, D. W. Schubert, and B. Scheid, Eur. J. Mech B 52, 68 (2015), 10.1016/j.euromechflu.2015.02.005; Phys. Fluids 28, 024109 (2016), 10.1063/1.4941762]. Due to its importance for a particular group of fiber spinning applications, a viscous-gravity-surface-tension regime, i.e., negligible effect of inertia, is analyzed separately. The mechanism underlying the destabilizing effect of surface tension is discussed and established stability criteria are tested for validity in the presence of surface tension.

  8. Review of Potential Candidate Stabilization Technologies for Liquid and Solid Secondary Waste Streams

    Energy Technology Data Exchange (ETDEWEB)

    Pierce, Eric M.; Mattigod, Shas V.; Westsik, Joseph H.; Serne, R. Jeffrey; Icenhower, Jonathan P.; Scheele, Randall D.; Um, Wooyong; Qafoku, Nikolla

    2010-01-30

    Pacific Northwest National Laboratory has initiated a waste form testing program to support the long-term durability evaluation of a waste form for secondary wastes generated from the treatment and immobilization of Hanford radioactive tank wastes. The purpose of the work discussed in this report is to identify candidate stabilization technologies and getters that have the potential to successfully treat the secondary waste stream liquid effluent, mainly from off-gas scrubbers and spent solids, produced by the Hanford Tank Waste Treatment and Immobilization Plant (WTP). Down-selection to the most promising stabilization processes/waste forms is needed to support the design of a solidification treatment unit (STU) to be added to the Effluent Treatment Facility (ETF). To support key decision processes, an initial screening of the secondary liquid waste forms must be completed by February 2010.

  9. Combined analytical and numerical approaches in Dynamic Stability analyses of engineering systems

    Science.gov (United States)

    Náprstek, Jiří

    2015-03-01

    Dynamic Stability is a widely studied area that has attracted many researchers from various disciplines. Although Dynamic Stability is usually associated with mechanics, theoretical physics or other natural and technical disciplines, it is also relevant to social, economic, and philosophical areas of our lives. Therefore, it is useful to occasionally highlight the general aspects of this amazing area, to present some relevant examples and to evaluate its position among the various branches of Rational Mechanics. From this perspective, the aim of this study is to present a brief review concerning the Dynamic Stability problem, its basic definitions and principles, important phenomena, research motivations and applications in engineering. The relationships with relevant systems that are prone to stability loss (encountered in other areas such as physics, other natural sciences and engineering) are also noted. The theoretical background, which is applicable to many disciplines, is presented. In this paper, the most frequently used Dynamic Stability analysis methods are presented in relation to individual dynamic systems that are widely discussed in various engineering branches. In particular, the Lyapunov function and exponent procedures, Routh-Hurwitz, Liénard, and other theorems are outlined together with demonstrations. The possibilities for analytical and numerical procedures are mentioned together with possible feedback from experimental research and testing. The strengths and shortcomings of these approaches are evaluated together with examples of their effective complementing of each other. The systems that are widely encountered in engineering are presented in the form of mathematical models. The analyses of their Dynamic Stability and post-critical behaviour are also presented. The stability limits, bifurcation points, quasi-periodic response processes and chaotic regimes are discussed. The limit cycle existence and stability are examined together with their

  10. Combined Influence of Strain and Heat Loss on Turbulent Premixed Flame Stabilization

    KAUST Repository

    Tay-Wo-Chong, Luis; Zellhuber, Mathieu; Komarek, Thomas; Im, Hong G.; Polifke, Wolfgang

    2015-01-01

    relation in terms of Markstein number, Karlovitz Number and a non-dimensional heat loss parameter was proposed for the combined influence of strain and heat losses on the consumption speed. Combining this empirical relation with a presumed probability

  11. Self-Assembled Mercaptan on Mesoporous Silica (SAMMS) technology of mercury removal and stabilization

    International Nuclear Information System (INIS)

    Feng, Xiangdong; Liu, Jun; Fryxell, G.E.

    1997-09-01

    This paper explains the technology developed to produce Self-Assembled Mercaptan on Mesoporous Silica (SAMMS) for mercury removal from aqueous wastewater and from organic wastes. The characteristics of SAMMS materials, including physical characteristics and mercury loading, and its application for mercury removal and stabilization are discussed. Binding kinetics and binding speciations are reported. Preliminary cost estimates are provided for producing SAMMS materials and for mercury removal from wastewater. The characteristics of SAMMS in mercury separation were studied at PNNL using simulated aqueous tank wastes and actual tritiated pump oil wastes from Savannah River Site; preliminary results are outlined. 47 refs., 16 figs., 16 tabs

  12. Self-Assembled Mercaptan on Mesoporous Silica (SAMMS) technology of mercury removal and stabilization

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Xiangdong; Liu, Jun; Fryxell, G.E. [and others

    1997-09-01

    This paper explains the technology developed to produce Self-Assembled Mercaptan on Mesoporous Silica (SAMMS) for mercury removal from aqueous wastewater and from organic wastes. The characteristics of SAMMS materials, including physical characteristics and mercury loading, and its application for mercury removal and stabilization are discussed. Binding kinetics and binding speciations are reported. Preliminary cost estimates are provided for producing SAMMS materials and for mercury removal from wastewater. The characteristics of SAMMS in mercury separation were studied at PNNL using simulated aqueous tank wastes and actual tritiated pump oil wastes from Savannah River Site; preliminary results are outlined. 47 refs., 16 figs., 16 tabs.

  13. Voicing the Technological Body. Some Musicological Reflections on Combinations of Voice and Technology in Popular Music

    Directory of Open Access Journals (Sweden)

    Florian Heesch

    2016-05-01

    Full Text Available The article deals with interrelations of voice, body and technology in popular music from a musicological perspective. It is an attempt to outline a systematic approach to the history of music technology with regard to aesthetic aspects, taking the identity of the singing subject as a main point of departure for a hermeneutic reading of popular song. Although the argumentation is based largely on musicological research, it is also inspired by the notion of presentness as developed by theologian and media scholar Walter Ong. The variety of the relationships between voice, body, and technology with regard to musical representations of identity, in particular gender and race, is systematized alongside the following cagories: (1 the “absence of the body,” that starts with the establishment of phonography; (2 “amplified presence,” as a signifier for uses of the microphone to enhance low sounds in certain manners; and (3 “hybridity,” including vocal identities that blend human body sounds and technological processing, whereby special focus is laid on uses of the vocoder and similar technologies.

  14. Composting technology in waste stabilization: On the methods, challenges and future prospects.

    Science.gov (United States)

    Onwosi, Chukwudi O; Igbokwe, Victor C; Odimba, Joyce N; Eke, Ifeanyichukwu E; Nwankwoala, Mary O; Iroh, Ikemdinachi N; Ezeogu, Lewis I

    2017-04-01

    Composting technology has become invaluable in stabilization of municipal waste due to its environmental compatibility. In this review, different types of composting methods reportedly applied in waste management were explored. Further to that, the major factors such as temperature, pH, C/N ratio, moisture, particle size that have been considered relevant in the monitoring of the composting process were elucidated. Relevant strategies to improve and optimize process effectiveness were also addressed. However, during composting, some challenges such as leachate generation, gas emission and lack of uniformity in assessing maturity indices are imminent. Here in, these challenges were properly addressed and some strategies towards ameliorating them were proffered. Finally, we highlighted some recent technologies that could improve composting. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Creating the integral engineer : Combining development education, sustainability, entrepreneurship and technology at Delft University of Technology

    NARCIS (Netherlands)

    Zwarteveen, J.W.; Blom, E.M.; Vastbinder, B.; Brezet, J.C.

    2010-01-01

    A modern engineer is more than a technical specialist. Training an integral engineer requires education in non-technical skills, including social and ethical aspects. Therefore, Delft University of Technology (DUT) introduced sustainable development and entrepreneurship into its bachelor and master

  16. Flutter suppression and stability analysis for a variable-span wing via morphing technology

    Science.gov (United States)

    Li, Wencheng; Jin, Dongping

    2018-01-01

    A morphing wing can enhance aerodynamic characteristics and control authority as an alternative to using ailerons. To use morphing technology for flutter suppression, the dynamical behavior and stability of a variable-span wing subjected to the supersonic aerodynamic loads are investigated numerically in this paper. An axially moving cantilever plate is employed to model the variable-span wing, in which the governing equations of motion are established via the Kane method and piston theory. A morphing strategy based on axially moving rates is proposed to suppress the flutter that occurs beyond the critical span length, and the flutter stability is verified by Floquet theory. Furthermore, the transient stability during the morphing motion is analyzed and the upper bound of the morphing rate is obtained. The simulation results indicate that the proposed morphing law, which is varying periodically with a proper amplitude, could accomplish the flutter suppression. Further, the upper bound of the morphing speed decreases rapidly once the span length is close to its critical span length.

  17. Combined Statistical Analyses for Long-Term Stability Data with Multiple Storage Conditions : A Simulation Study

    NARCIS (Netherlands)

    Almalik, Osama; Nijhuis, Michiel B.; van den Heuvel, Edwin R.

    2014-01-01

    Shelf-life estimation usually requires that at least three registration batches are tested for stability at multiple storage conditions. The shelf-life estimates are often obtained by linear regression analysis per storage condition, an approach implicitly suggested by ICH guideline Q1E. A linear

  18. Technological parameters and oxidative stability of irradiated wheat and corn flour

    International Nuclear Information System (INIS)

    Silva, Roberta Claro da

    2003-01-01

    Cereals are susceptible to the attack of insects and microorganisms development during storage. Researches have demonstrated the viability of the use of the irradiation technology for the preservation and reduction of these losses. The objective of this work was to evaluate the effect of different irradiation doses (0; 3; 4,5 and 6 kGy) on wheat and corn flour oxidative stability and technological quality. Physicochemical and sensory analyses were performed on the flours. The technological parameters evaluated on the wheat flour were farinogram, alveogram, falling number, and a baking experiment. The packed samples were irradiated in a commercial irradiator and stored under ambient conditions. The oxidative quality of both flours was not affected in any of the treatments, within the commercial shelf life period guaranteed by the manufacturers for non irradiated products. However, flours acid value was the analytical parameter that reflected the irradiation effect. The higher flour initial acid values were the larger the increments with storage. The 4.5 and 6 kGy treatments ha a negative effect on the technological quality of the wheat flour. The irradiated flours had their viscoelastic properties affected the higher the irradiation dose, the stronger the effect. None of the treatments affected the sensorial quality of the samples, although a metallic odor was perceived by some tasters. (author)

  19. Comparing and Combining Measurement-Based and Driven-Dissipative Entanglement Stabilization*

    Directory of Open Access Journals (Sweden)

    Y. Liu

    2016-03-01

    Full Text Available We demonstrate and contrast two approaches to the stabilization of qubit entanglement by feedback. Our demonstration is built on a feedback platform consisting of two superconducting qubits coupled to a cavity, which are measured by a nearly quantum-limited measurement chain and controlled by high-speed classical logic circuits. This platform is used to stabilize entanglement by two nominally distinct schemes: a “passive” reservoir engineering method and an “active” correction based on conditional parity measurements. In view of the instrumental roles that these two feedback paradigms play in quantum error correction and quantum control, we directly compare them on the same experimental setup. Furthermore, we show that a second layer of feedback can be added to each of these schemes, which heralds the presence of a high-fidelity entangled state in real time. This “nested” feedback brings about a marked entanglement fidelity improvement without sacrificing success probability.

  20. Dynamic and Static Combination Analysis Method of Slope Stability Analysis during Earthquake

    OpenAIRE

    Liang Lu; Zongjian Wang; Xiaoyuan Huang; Bin Zheng; Katsuhiko Arai

    2014-01-01

    The results of laboratory model tests for simulating the slope failure due to vibration, including unreinforced slope and the slope reinforced by using geotextile, show that the slope failure occurs when a cumulative plastic displacement exceeds a certain critical value. To overcome the defects of conventional stability analysis, which evaluates the slope characteristics only by its strength parameters, a numerical procedure considering the stiffness and deformation of materials and geosynthe...

  1. Estimating the power efficiency of the thermal power plant modernization by using combined-cycle technologies

    International Nuclear Information System (INIS)

    Hovhannisyan, L.S.; Harutyunyan, N.R.

    2013-01-01

    The power efficiency of the thermal power plant (TPP) modernization by using combined-cycle technologies is introduced. It is shown that it is possible to achieve the greatest decrease in the specific fuel consumption at modernizing the TPP at the expense of introducing progressive 'know-how' of the electric power generation: for TPP on gas, it is combined-cycle, gas-turbine superstructures of steam-power plants and gas-turbines with heat utilization

  2. Uncovering stability mechanisms in microbial ecosystems - combining microcosm experiments, computational modelling and ecological theory in a multidisciplinary approach

    Science.gov (United States)

    Worrich, Anja; König, Sara; Banitz, Thomas; Centler, Florian; Frank, Karin; Kästner, Matthias; Miltner, Anja; Thullner, Martin; Wick, Lukas

    2015-04-01

    Although bacterial degraders in soil are commonly exposed to fluctuating environmental conditions, the functional performance of the biodegradation processes can often be maintained by resistance and resilience mechanisms. However, there is still a gap in the mechanistic understanding of key factors contributing to the stability of such an ecosystem service. Therefore we developed an integrated approach combining microcosm experiments, simulation models and ecological theory to directly make use of the strengths of these disciplines. In a continuous interplay process, data, hypotheses, and central questions are exchanged between disciplines to initiate new experiments and models to ultimately identify buffer mechanisms and factors providing functional stability. We focus on drying and rewetting-cycles in soil ecosystems, which are a major abiotic driver for bacterial activity. Functional recovery of the system was found to depend on different spatial processes in the computational model. In particular, bacterial motility is a prerequisite for biodegradation if either bacteria or substrate are heterogeneously distributed. Hence, laboratory experiments focussing on bacterial dispersal processes were conducted and confirmed this finding also for functional resistance. Obtained results will be incorporated into the model in the next step. Overall, the combination of computational modelling and laboratory experiments identified spatial processes as the main driving force for functional stability in the considered system, and has proved a powerful methodological approach.

  3. Combining structural modeling with ensemble machine learning to accurately predict protein fold stability and binding affinity effects upon mutation.

    Directory of Open Access Journals (Sweden)

    Niklas Berliner

    Full Text Available Advances in sequencing have led to a rapid accumulation of mutations, some of which are associated with diseases. However, to draw mechanistic conclusions, a biochemical understanding of these mutations is necessary. For coding mutations, accurate prediction of significant changes in either the stability of proteins or their affinity to their binding partners is required. Traditional methods have used semi-empirical force fields, while newer methods employ machine learning of sequence and structural features. Here, we show how combining both of these approaches leads to a marked boost in accuracy. We introduce ELASPIC, a novel ensemble machine learning approach that is able to predict stability effects upon mutation in both, domain cores and domain-domain interfaces. We combine semi-empirical energy terms, sequence conservation, and a wide variety of molecular details with a Stochastic Gradient Boosting of Decision Trees (SGB-DT algorithm. The accuracy of our predictions surpasses existing methods by a considerable margin, achieving correlation coefficients of 0.77 for stability, and 0.75 for affinity predictions. Notably, we integrated homology modeling to enable proteome-wide prediction and show that accurate prediction on modeled structures is possible. Lastly, ELASPIC showed significant differences between various types of disease-associated mutations, as well as between disease and common neutral mutations. Unlike pure sequence-based prediction methods that try to predict phenotypic effects of mutations, our predictions unravel the molecular details governing the protein instability, and help us better understand the molecular causes of diseases.

  4. Identification of drug combinations administered by continuous subcutaneous infusion that require analysis for compatibility and stability

    OpenAIRE

    Dickman, Andrew; Bickerstaff, Matthew; Jackson, Richard; Schneider, Jennifer; Mason, Stephen; Ellershaw, John

    2017-01-01

    Background A continuous subcutaneous infusion (CSCI) delivered via syringe pump is a method of drug administration used to maintain symptom control when a patient is no longer able to tolerate oral medication. Several classes of drugs, such as opioids, antiemetics, anticholinergics, antipsychotics and benzodiazepines are routinely administered by CSCI alone or in combinations. Previous studies attempting to identify the most-common CSCI combinations are now several years old and no longer ref...

  5. Overview of advanced technologies for stabilization of 238Pu-contaminated waste

    International Nuclear Information System (INIS)

    Ramsey, K.B.; Foltyn, E.M.; Heslop, J.M.

    1998-02-01

    This paper presents an overview of potential technologies for stabilization of 238 Pu-contaminated waste. Los Alamos National Laboratory (LANL) has processed 238 PuO 2 fuel into heat sources for space and terrestrial uses for the past several decades. The 88-year half-life of 238 Pu and thermal power of approximately 0.6 watts/gram make this isotope ideal for missions requiring many years of dependable service in inaccessible locations. However, the same characteristic which makes 238 Pu attractive for heat source applications, the high Curie content (17 Ci/gram versus 0.06 Ci/gram for 239 Pu ), makes disposal of 238 Pu-contaminated waste difficult. Specifically, the thermal load limit on drums destined for transport to the Waste Isolation Pilot Plant (WIPP), 0.23 gram per drum for combustible waste, is impossible to meet for nearly all 238 Pu-contaminated glovebox waste. Use of advanced waste treatment technologies including Molten Salt Oxidation (MSO) and aqueous chemical separation will eliminate the combustible matrix from 238 Pu-contaminated waste and recover kilogram quantities of 238 PuO 2 from the waste stream. A conceptual design of these advanced waste treatment technologies will be presented

  6. Combination of acid-resistor and -scavenger improves the SEI stability and cycling ability of tin–nickel battery anodes in LiPF6-containing electrolyte

    International Nuclear Information System (INIS)

    Choo, Myeong-Ho; Nguyen, Cao Cuong; Hong, Sukhyun; Kwon, Yo Han; Woo, Sang-Wook; Kim, Je Young; Song, Seung-Wan

    2013-01-01

    Control of electrode–electrolyte interfacial reactivity and the formation of the solid electrolyte interphase (SEI) layer is a key technology for high performance rechargeable lithium batteries. Here we present the first report on a promising interfacial approach for Sn–Ni electrode that the use of acid-resisting and -scavenging fluorine-dopant on Sn combined with acid-scavenging trimethyl phosphite electrolyte additive to LiPF 6 -contiaing carbonate-based organic electrolyte improves the interfacial stability of Sn to acidic electrolyte species. As a result, a stable SEI layer consisting of a plenty of carbonate decomposition products forms and cycling ability significantly improves, in contrast to less efficient SEI formation and rapid performance fade for the electrodes without fluorine-dopant or trimethyl phosphite additive

  7. Physical and oxidative stability of high fat fish oil-in-water emulsions stabilized with combinations of sodium caseinate and sodium alginate

    DEFF Research Database (Denmark)

    Yesiltas, Betül; García Moreno, Pedro Jesús; Sørensen, Ann-Dorit Moltke

    2017-01-01

    .2 ratio NaCas:NaAlg by Box-Behnken's design, the formulae 70%-1.4%-1.2 was decided due to high fish oil content's decreasing effect on droplet size and peroxide value. Practical applications: Physically and oxidatively stable high fat (50-70%) omega-3 delivery fish oil-in-water emulsions are of high......A systematic study was carried out in order to evaluate the physical and oxidative stability of high fat omega-3 delivery fish oil-in-water emulsions stabilized with combinations of sodium caseinate (NaCas) and sodium alginate (NaAlg). The influence of 3 factors related to emulsion composition...... (fish oil content: 50, 60 and 70%; total amount of NaCas and NaAlg: 1.4, 2.1 and 2.8 %; and ratio NaCas:NaAlg: 0.4, 1.2 and 2) on physical (droplet size, viscosity and zeta potential) and oxidative (primary and secondary oxidation products) parameters was evaluated. It was possible to produce emulsions...

  8. Color stabilization of porcine hemoglobin during spray-drying and powder storage by combining chelating and reducing agents.

    Science.gov (United States)

    Salvador, P; Toldrà, M; Parés, D; Carretero, C; Saguer, E

    2009-10-01

    This work focuses on the effects of adding a chelating agent - such as nicotinic acid (NA, 2% w/v) or nicotinamide (Nam, 2.5% w/v) - along with glucose as a reducing agent (G, 10% w/v) to fresh porcine hemoglobin in order to stabilize its red color during spray-drying and powder storage at room temperature. Correlations between the CIELAB color parameters and the relative percentages of the different hemoglobin derivatives (liganded and deliganded ferrohemoglobin, and methemoglobin) were analyzed. The results indicate that, although little effects could be observed for any of the combined treatments on fresh hemoglobin, they were effective against pigment autoxidation during dehydration and subsequent storage. From the results, it can also be concluded that glucose was the main contributor to the color stabilization of the hemoglobin powder, probably due to its high water retention capacity.

  9. Stability-indicating RP-HPLC method for simultaneous determination of gatifloxacin and flurbiprofen in binary combination

    Directory of Open Access Journals (Sweden)

    Islam Ullah Khan

    2014-04-01

    Full Text Available A stability-indicating RP-HPLC method is presented for determination of gatifloxacin and flurbiprofen in binary combination. Gatifloxacin, flurbiprofen and their degradation products were detected at 254 nm using a BDS Hypersil C8 (250 X 4.6 mm, 5 µm column and mixture of 20 mM phosphate buffer (pH 3.0 and methanol 30:70 v/v as mobile phase. Response was linear over the range of 15-105 mg mL-1 for gatifloxacin (r² > 0.998 and of 1.5-10.5 mg mL-1 for flurbiprofen (r² > 0.999. The developed method efficiently separated the analytical peaks from degradation products (peak purity index > 0.9999. The method developed can be applied successfully for determination of gatifloxacin and flurbiprofen in human serum, urine, pharmaceutical formulations, and their stability studies.

  10. Stability Indicating LC-Method for Estimation of Paracetamol and Lornoxicam in Combined Dosage Form

    OpenAIRE

    Shah, Dimal A.; Patel, Neel J.; Baldania, Sunil L.; Chhalotiya, Usman K.; Bhatt, Kashyap K.

    2011-01-01

    A simple, specific and stability indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of paracetamol and lornoxicam in tablet dosage form. A Brownlee C-18, 5 μm column having 250×4.6 mm i.d. in isocratic mode, with mobile phase containing 0.05 M potassium dihydrogen phosphate:methanol (40:60, v/v) was used. The flow rate was 1.0 ml/min and effluents were monitored at 266 nm. The retention times of paracetamol and lornoxicam ...

  11. The radiofrequency frontier: a review of radiofrequency and combined radiofrequency pulsed-light technology in aesthetic medicine.

    Science.gov (United States)

    Sadick, Neil; Sorhaindo, Lian

    2005-05-01

    Radiofrequency (RF) and combined RF light source technologies have established themselves as safe and effective treatment modalities for several dermatologic procedures, including skin tightening, hair and leg vein removal, acne scarring, skin rejuvenation, and wrinkle reduction. This article reviews the technology, clinical applications, and recent advances of RF and combined RF light/laser source technologies in aesthetic medicine.

  12. Combinative Particle Size Reduction Technologies for the Production of Drug Nanocrystals

    Directory of Open Access Journals (Sweden)

    Jaime Salazar

    2014-01-01

    Full Text Available Nanosizing is a suitable method to enhance the dissolution rate and therefore the bioavailability of poorly soluble drugs. The success of the particle size reduction processes depends on critical factors such as the employed technology, equipment, and drug physicochemical properties. High pressure homogenization and wet bead milling are standard comminution techniques that have been already employed to successfully formulate poorly soluble drugs and bring them to market. However, these techniques have limitations in their particle size reduction performance, such as long production times and the necessity of employing a micronized drug as the starting material. This review article discusses the development of combinative methods, such as the NANOEDGE, H 96, H 69, H 42, and CT technologies. These processes were developed to improve the particle size reduction effectiveness of the standard techniques. These novel technologies can combine bottom-up and/or top-down techniques in a two-step process. The combinative processes lead in general to improved particle size reduction effectiveness. Faster production of drug nanocrystals and smaller final mean particle sizes are among the main advantages. The combinative particle size reduction technologies are very useful formulation tools, and they will continue acquiring importance for the production of drug nanocrystals.

  13. A City Parking Integration System Combined with Cloud Computing Technologies and Smart Mobile Devices

    Science.gov (United States)

    Yeh, Her-Tyan; Chen, Bing-Chang; Wang, Bo-Xun

    2016-01-01

    The current study applied cloud computing technology and smart mobile devices combined with a streaming server for parking lots to plan a city parking integration system. It is also equipped with a parking search system, parking navigation system, parking reservation service, and car retrieval service. With this system, users can quickly find…

  14. Combination of low energy and mechanical cooling technologies for buildings in Central Europe

    NARCIS (Netherlands)

    Lain, M.; Hensen, J.L.M.

    2004-01-01

    This paper discusses options for incorporating low energy cooling technologies combined with standard mechanical cooling in buildings in central Europe. Case studies, design recommendations and role of computer simulation of building and system in the design process are presented. Applicability of

  15. Enhancement of Orthodontic Anchor Screw Stability Under Immediate Loading by Ultraviolet Photofunctionalization Technology.

    Science.gov (United States)

    Takahashi, Maiko; Motoyoshi, Mitsuru; Inaba, Mizuki; Hagiwara, Yoshiyuki; Shimizu, Noriyoshi

    Ultraviolet (UV)-mediated photofunctionalization technology is intended to enhance the osseointegration capability of titanium implants. There are concerns about orthodontic anchor screws loosening under immediate loading protocols in adolescent orthodontic treatment. The purpose of this in vivo study was to evaluate the effects of photofunctionalization on the intrabony stability of orthodontic titanium anchor screws and bone-anchor screw contact under immediate loading in growing rats. Custom-made titanium anchor screws (1.4 mm in diameter and 4.0 mm in length) with or without photofunctionalization pretreatment were placed on the proximal epiphysis of the tibial bone in 6-week-old male Sprague-Dawley rats and were loaded immediately after placement. After 2 weeks of loading, the stability of the anchor screws was evaluated using a Periotest device, and the bone-anchor screw contact ratio (BSC) was assessed by a histomorphometric analysis using field-emission scanning electron microscopy. In the unloaded group, Periotest values (PTVs) were ~25 for UV-untreated screws and 13 for UVtreated screws (P < .01), while in the immediate-loading group, PTVs were 28 for UV-untreated screws and 16 for UV-treated screws (P < .05). Significantly less screw mobility was observed in both UV-treated groups regardless of the loading protocol. The BSC was increased ~1.8 fold for UV-treated screws, compared with UV-untreated screws, regardless of the loading protocol. Photofunctionalization enhanced the intrabony stability of orthodontic anchor screws under immediate loading in growing rats by increasing bone-anchor screw contact.

  16. Basis of combined Pinch Technology and exergy analysis and its application to energy industry in Mexico

    International Nuclear Information System (INIS)

    Rodriguez T, M.A.; Rangel D, H.

    1994-01-01

    The energy industry scheme in Mexico has an enormous potential to do re adaptations with the intention of increase the efficiency in the use of energy. One of the most modern engineering tools to make such re adaptations consist in a suitable combination of analysis of exergy and Pinch technology. In this work, the basis of this new technology are presented, besides the potential areas of application in the Mexican energy industry are also considered. So then, it is shown that a combined analysis of exergy and Pinch technology (ACETP) is useful to analyze, in a conceptual and easy to understand way, systems that involve heat and power. The potential areas of application of ACETP are, cryogenic processes, power generation systems and cogeneration systems. (Author)

  17. Multipurpose units: combining of technological operations of a soil cultivating and seeding

    Directory of Open Access Journals (Sweden)

    D. A. Petukhov

    2015-01-01

    Full Text Available The modern domestic market of technique for grain crops seeding differs variety of machines brands and types. The intensive type technologies combining technological operations of a soil cultivating and grain crops seeding in one pass are more widely used. The authors have established that one-operational units in new machine park have to be replaced multipurpose, universal and combined machines. Such approach will reduce number of machines in grain production from 20-30 to 5-6 name titles. Possibilities of multipurpose sowing units for simultaneous fertilizers application, soil cultivating and weeds destruction were analyzed. It was specified that nowadays there are several technologies types with two, four or six operations overlapping. Operational performance, technological and economical efficiency of the best multipurpose and also efficiency of technological operations overlapping at grain crops cultivating in the conditions of their real operation and at a trial establishment in the Kuban research institute of information and technical and economic studies of agro-industrial complex engineering and technical services were studied. Tit was defined that use of multipurpose sowing units and also studied efficiency of decreases operational costs by 48-71 percent, fuel consumption - by 41-76 percent and reduces labor input by 72-80 percent. Thus grain crops seeding is possible in optimal agrotime because of 4-6 technological operations overlapping in one pass.

  18. Combined Characterization Techniques to Understand the Stability of a Variety of Organic Photovoltaic Devices - the ISOS-3 inter- laboratory collaboration

    DEFF Research Database (Denmark)

    Lira-Cantu, Monica; Tanenbaum, David M.; Norrman, Kion

    2012-01-01

    . The results reported from the combination of the different characterization techniques results in a proposed degradation mechanism. The final conclusion is that the failure of the photovoltaic response of the device with time under full sun solar simulation, is mainly due to the degradation of the electrodes...... and not to the active materials of the solar cell.......This work is part of the inter-laboratory collaboration to study the stability of seven distinct sets of state-of-the-art organic photovoltaic (OPVs) devices prepared by leading research laboratories. All devices have been shipped to and degraded at the Danish Technical University (DTU, formerly...

  19. Combined radiolysis/GLC as a tool for the investigation of stabilizing mechanisms

    International Nuclear Information System (INIS)

    Koch, J.; Eckert, W.R.

    1977-01-01

    Combined radiolysis/GLC was used to prove the chemical incorporation of lauric acid from cadmium laurate into polyvinyl chloride. The samples were exposed for 10 days to x-rays at a dose rate of 0.345 Mrad/hr

  20. In-situ Adsorption-Biological Combined Technology Treating Sediment Phosphorus in all Fractions

    Science.gov (United States)

    Zhang, Y.; Wang, C.; He, F.; Liu, B.; Xu, D.; Xia, S.; Zhou, Q.; Wu, Z.

    2016-07-01

    The removal efficiency of sediment phosphorus (P) in all fractions with in-situ adsorption-biological combined technology was studied in West Lake, Hangzhou, China. The removal amounts of sediment Ca-P, Fe/Al-P, IP, OP and TP by the combined effect of PCFM (Porous ceramic filter media) and V. spiralis was 61 mg/kg, 249 mg/kg, 318 mg/kg, 85 mg/kg and 416 mg/kg, respectively, and the corresponding removing rate reached 10.5%, 44.6%, 27.5%, 30.6% and 29.2%. This study suggested that the combination of PCFM and V. spiralis could achieve a synergetic sediment P removal because the removal rates of the combinations were higher than the sum of that of PCFM and macrophytes used separately. From analysis of sediment microbial community and predicted function, we found that the combined PCFM and V. spiralis enhanced the function of P metabolism by increasing specific genus that belong to phylum Firmicutes and Nitrospirae. Thus it can be seen the in-situ adsorption-biological combined technology could be further applied to treat internal P loading in eutrophic waters.

  1. Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening

    Directory of Open Access Journals (Sweden)

    Yoon-Dong Park

    2016-08-01

    Full Text Available Cryptococcus neoformans is a pathogenic fungus that is responsible for up to half a million cases of meningitis globally, especially in immunocompromised individuals. Common fungistatic drugs, such as fluconazole, are less toxic for patients but have low efficacy for initial therapy of the disease. Effective therapy against the disease is provided by the fungicidal drug amphotericin B; however, due to its high toxicity and the difficulty in administering its intravenous formulation, it is imperative to find new therapies targeting the fungus. The antiparasitic drug bithionol has been recently identified as having potent fungicidal activity. In this study, we used a combined gene dosing and drug affinity responsive target stability (GD-DARTS screen as well as protein modeling to identify a common drug binding site of bithionol within multiple NAD-dependent dehydrogenase drug targets. This combination genetic and proteomic method thus provides a powerful method for identifying novel fungicidal drug targets for further development.

  2. Selectivity and stability of herbicides and herbicide combinations for the grain yield of maize (Zea Mays L.

    Directory of Open Access Journals (Sweden)

    T. Barakova

    2016-09-01

    Full Text Available Abstract. The research was conducted during 2012 - 2014 on pellic vertisol soil type. Under investigation was cycloxydim tolerant maize hybrid Ultrafox duo (Zea mays L.. Factor A included the years of investigation. Factor B included no treated check and 3 soil-applied herbicides – Adengo 465 SC (isoxaflutol + tiencarbazon – 440 ml/ha, Wing P (pendimethalin + dimethenamid – 4 l/ha and Lumax 538 SC (S-metolachlor + terbuthylazine + mesotrione – 4 l/ha. Factor C included no treated check and 5 foliar-applied herbicides – Stellar 210 SL (topramezon + dicamba – 1 l/ha, Principal plus (nicosulfuron + rimsulfuron + dicamba – 380 g/ha, Ventum WG (foramsulfuron + iodosulfuron – 150 g/ha, Monsun active OD (foramsulfuron + tiencarbazon – 1.5 l/ha and Laudis OD (tembotrione – 2 l/ha. In addition to these variants by conventional technology for maize growing one variant by Duo system technology is also included in the experiment. It includes soil-applied herbicide Merlin flex 480 SC (isoxaflutole – 420 g/ha and tank mixture of antigraminaceous herbicide Focus ultra (cycloxydim - 2 l/ha + antibroadleaved herbicide Kalam (tritosulfuron + dicamba – 300 g/ha. It is found that herbicide combination of soil-applied herbicide Merlin flex with tank mixture Focus ultra + Kalam by Duo system technology leads to obtaining high grain yield. High yields of maize grain are also obtained by herbicide combinations Lumax + Principal plus, Lumax + Laudis and Wing + Principal plus. The most unstable are the non-treated check and single use of soilapplied herbicides Adengo, Wing and Lumax. Technologically the most valuable are herbicide combination Merlin flex + Focus ultra + Kalam by Duo system technology, followed by combinations of foliar-applied herbicides Principal plus and Laudis with soil-applied herbicides Adengo, Wing and Lumax by conventional technology. Single use of herbicides has low estimate due to must to combine soil-applied with foliar

  3. Accurate prediction of stability changes in protein mutants by combining machine learning with structure based computational mutagenesis.

    Science.gov (United States)

    Masso, Majid; Vaisman, Iosif I

    2008-09-15

    Accurate predictive models for the impact of single amino acid substitutions on protein stability provide insight into protein structure and function. Such models are also valuable for the design and engineering of new proteins. Previously described methods have utilized properties of protein sequence or structure to predict the free energy change of mutants due to thermal (DeltaDeltaG) and denaturant (DeltaDeltaG(H2O)) denaturations, as well as mutant thermal stability (DeltaT(m)), through the application of either computational energy-based approaches or machine learning techniques. However, accuracy associated with applying these methods separately is frequently far from optimal. We detail a computational mutagenesis technique based on a four-body, knowledge-based, statistical contact potential. For any mutation due to a single amino acid replacement in a protein, the method provides an empirical normalized measure of the ensuing environmental perturbation occurring at every residue position. A feature vector is generated for the mutant by considering perturbations at the mutated position and it's ordered six nearest neighbors in the 3-dimensional (3D) protein structure. These predictors of stability change are evaluated by applying machine learning tools to large training sets of mutants derived from diverse proteins that have been experimentally studied and described. Predictive models based on our combined approach are either comparable to, or in many cases significantly outperform, previously published results. A web server with supporting documentation is available at http://proteins.gmu.edu/automute.

  4. Combined Influence of Strain and Heat Loss on Turbulent Premixed Flame Stabilization

    KAUST Repository

    Tay-Wo-Chong, Luis

    2015-11-16

    The present paper argues that the prediction of turbulent premixed flames under non-adiabatic conditions can be improved by considering the combined effects of strain and heat loss on reaction rates. The effect of strain in the presence of heat loss on the consumption speed of laminar premixed flames was quantified by calculations of asymmetric counterflow configurations (“fresh-to-burnt”) with detailed chemistry. Heat losses were introduced by setting the temperature of the incoming stream of products on the “burnt” side to values below those corresponding to adiabatic conditions. The consumption speed decreased in a roughly exponential manner with increasing strain rate, and this tendency became more pronounced in the presence of heat losses. An empirical relation in terms of Markstein number, Karlovitz Number and a non-dimensional heat loss parameter was proposed for the combined influence of strain and heat losses on the consumption speed. Combining this empirical relation with a presumed probability density function for strain in turbulent flows, an attenuation factor that accounts for the effect of strain and heat loss on the reaction rate in turbulent flows was deduced and implemented into a turbulent combustion model. URANS simulations of a premixed swirl burner were carried out and validated against flow field and OH chemiluminescence measurements. Introducing the effects of strain and heat loss into the combustion model, the flame topology observed experimentally was correctly reproduced, with good agreement between experiment and simulation for flow field and flame length.

  5. [Stability of ventral, dorsal and combined spondylodesis in vertebral body prosthesis implantation].

    Science.gov (United States)

    Vahldiek, M; Gossè, F; Panjabi, M M

    2002-05-01

    The purpose of this study was to evaluate the biomechanical characteristics of short-segment anterior, posterior, and combined instrumentations in lumbar spine vertebral body replacement surgery. Eight fresh frozen human cadaveric thoracolumbar spine specimens (T12-L4) were prepared for biomechanical testing. Pure moments (2.5, 5, and 7.5 Nm) of flexion-extension, left-right axial torsion, and left-right lateral bending were applied to the top vertebra in a flexibility machine and the motions of L1 vertebra with respect to L3 were recorded with an optoelectronic motion measurement system after preconditioning. One anterior, two posterior pedicle screw systems, and two combined instrumentations were tested. Load-displacement curves were recorded and neutral zone (NZ) and range of motion (ROM) were determined. The anterior instrumentation, after vertebral body replacement, showed greater motion than the intact spine, especially in axial torsion. Posterior instrumentation provided greater rigidity than the anterior instrumentation, especially in flexion-extension. The combined instrumentation provided superior rigidity in all directions compared to all other instrumentations.

  6. Mineral nutrition as a factor of stability of technological quality in winter wheat cultivars

    Directory of Open Access Journals (Sweden)

    Đurić Veselinka

    2005-01-01

    Full Text Available Afield trial was carried out with eight cultivars (Libellula, Drina, Sremica NSR-2, Jugoslavija, Somborka, Lasta and Pobeda of winter wheat (Trticum aestivum L representing several different periods in our country's wheat selection and having different potentials for technological grain quality. Six different rates of nitrogen fertilizer were tested: 0, 60, 90, 120, 150 and 180 kgNha-1. Increasing N fertilizer rates resulted in a linear increase of the direct and indirect indicators of quality. The best results were obtained with the cultivar Sremica and the poorest with Lasta, while Jugoslavija and Pobeda were shown to be of approximately the same quality. The contribution of N fertilizer variance to total variance was the largest for protein content (43.7%. N nutrition had a greater influence on protein content in cultivars from the earlier periods of selection. Its effect on sedimentation value, on the other hand, was greater in the recently released cultivars. The contribution of the genetic factor to total variance was the highest for crumb value number (CVN (58.7% and bread volume yield (44.2% and the lowest for protein content (20.8%. The absence of significant differences in the CVN means at any of the N nutrition levels studied resulted from the variability of the indirect indicators closely linked with the direct indicators of baking quality, showing the importance of N nutrition for maintaining the stability of technological quality in winter wheat cultivars.

  7. Combining slope stability and groundwater flow models to assess stratovolcano collapse hazard

    Science.gov (United States)

    Ball, J. L.; Taron, J.; Reid, M. E.; Hurwitz, S.; Finn, C.; Bedrosian, P.

    2016-12-01

    Flank collapses are a well-documented hazard at volcanoes. Elevated pore-fluid pressures and hydrothermal alteration are invoked as potential causes for the instability in many of these collapses. Because pore pressure is linked to water saturation and permeability of volcanic deposits, hydrothermal alteration is often suggested as a means of creating low-permeability zones in volcanoes. Here, we seek to address the question: What alteration geometries will produce elevated pore pressures in a stratovolcano, and what are the effects of these elevated pressures on slope stability? We initially use a finite element groundwater flow model (a modified version of OpenGeoSys) to simulate `generic' stratovolcano geometries that produce elevated pore pressures. We then input these results into the USGS slope-stability code Scoops3D to investigate the effects of alteration and magmatic intrusion on potential flank failure. This approach integrates geophysical data about subsurface alteration, water saturation and rock mechanical properties with data about precipitation and heat influx at Cascade stratovolcanoes. Our simulations show that it is possible to maintain high-elevation water tables in stratovolcanoes given specific ranges of edifice permeability (ideally between 10-15 and 10-16 m2). Low-permeability layers (10-17 m2, representing altered pyroclastic deposits or altered breccias) in the volcanoes can localize saturated regions close to the surface, but they may actually reduce saturation, pore pressures, and water table levels in the core of the volcano. These conditions produce universally lower factor-of-safety (F) values than at an equivalent dry edifice with the same material properties (lower values of F indicate a higher likelihood of collapse). When magmatic intrusions into the base of the cone are added, near-surface pore pressures increase and F decreases exponentially with time ( 7-8% in the first year). However, while near-surface impermeable layers

  8. Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up

    Science.gov (United States)

    2012-01-01

    The global demand for artemisinin-based combination therapy (ACT) has grown sharply since its recommendation by the World Health Organization in 2002. However, a combination of financing and programmatic uncertainties, limited suppliers of finished products, information opacity across the different tiers in the supply chain, and widespread fluctuations in raw material prices have together contributed to a market fraught with demand and supply uncertainties and price volatility. Various short-term solutions have been deployed to alleviate supply shortages caused by these challenges; however, new mechanisms are required to build resilience into the supply chain. This review concludes that a mix of strategies is required to stabilize the artemisinin and ACT market. First, better and more effective pooling of demand and supply risks and better contracting to allow risk sharing among the stakeholders are needed. Physical and financial buffer stocks will enable better matching of demand and supply in the short and medium term. Secondly, physical buffers will allow stable supplies when there are procurement and supply management challenges while financial buffer funds will address issues around funding disruptions. Finally, in the medium to long term, significant investments in country level system strengthening will be required to minimize national level demand uncertainties. In addition a voluntary standard for extractors to ensure appropriate purchasing and sales practices as well as minimum quality and ethical standards could help stabilize the artemisinin market in the long term. PMID:23198961

  9. Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up

    Directory of Open Access Journals (Sweden)

    Shretta Rima

    2012-12-01

    Full Text Available Abstract The global demand for artemisinin-based combination therapy (ACT has grown sharply since its recommendation by the World Health Organization in 2002. However, a combination of financing and programmatic uncertainties, limited suppliers of finished products, information opacity across the different tiers in the supply chain, and widespread fluctuations in raw material prices have together contributed to a market fraught with demand and supply uncertainties and price volatility. Various short-term solutions have been deployed to alleviate supply shortages caused by these challenges; however, new mechanisms are required to build resilience into the supply chain. This review concludes that a mix of strategies is required to stabilize the artemisinin and ACT market. First, better and more effective pooling of demand and supply risks and better contracting to allow risk sharing among the stakeholders are needed. Physical and financial buffer stocks will enable better matching of demand and supply in the short and medium term. Secondly, physical buffers will allow stable supplies when there are procurement and supply management challenges while financial buffer funds will address issues around funding disruptions. Finally, in the medium to long term, significant investments in country level system strengthening will be required to minimize national level demand uncertainties. In addition a voluntary standard for extractors to ensure appropriate purchasing and sales practices as well as minimum quality and ethical standards could help stabilize the artemisinin market in the long term.

  10. Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up.

    Science.gov (United States)

    Shretta, Rima; Yadav, Prashant

    2012-12-02

    The global demand for artemisinin-based combination therapy (ACT) has grown sharply since its recommendation by the World Health Organization in 2002. However, a combination of financing and programmatic uncertainties, limited suppliers of finished products, information opacity across the different tiers in the supply chain, and widespread fluctuations in raw material prices have together contributed to a market fraught with demand and supply uncertainties and price volatility. Various short-term solutions have been deployed to alleviate supply shortages caused by these challenges; however, new mechanisms are required to build resilience into the supply chain. This review concludes that a mix of strategies is required to stabilize the artemisinin and ACT market. First, better and more effective pooling of demand and supply risks and better contracting to allow risk sharing among the stakeholders are needed. Physical and financial buffer stocks will enable better matching of demand and supply in the short and medium term. Secondly, physical buffers will allow stable supplies when there are procurement and supply management challenges while financial buffer funds will address issues around funding disruptions. Finally, in the medium to long term, significant investments in country level system strengthening will be required to minimize national level demand uncertainties. In addition a voluntary standard for extractors to ensure appropriate purchasing and sales practices as well as minimum quality and ethical standards could help stabilize the artemisinin market in the long term.

  11. Surgical Stabilization of Costoclavicular Injuries - A Combination of Flail Chest Injuries and a Clavicula Fracture.

    Science.gov (United States)

    Langenbach, Andreas; Pinther, Melina; Krinner, Sebastian; Grupp, Sina; Ekkernkamp, Axel; Hennig, Friedrich F; Schulz-Drost, Stefan

    2017-01-01

    Background: Flail chest injuries (FCI) are associated with a high morbidity and mortality rate. As a concomitant clavicle fracture in FCI even worsens the outcome, the question is how can those costoclavicular injuries (CCI) be managed surgically. Methods: 11 patients with CCI were surgically treated by a locked plate osteosynthesis of the Clavicle and the underlying ribs through limited surgical approaches under general anesthesia. Patients were followed up after 2, 6, 12, 26 and 52 weeks. Results: All patients showed severe chest wall deformity due to severely displaced fractures of the ribs and the clavicle. They were suffering from pain and restriction of respiratory movements. The chest wall could be restored to normal shape in all cases with uneventful bone healing and a high patient convenience. Fractures of the clavicle and the second rib were managed through an innovative clavipectoral approach, the others through standard approaches to the anterolateral and the posterolateral chest wall. Two patients complained about numbness around the lateral approach and lasting periscapular pain. Conclusions: Surgical stabilization might be the appropriate therapy in CCI with dislocated fractures since they would cause severe deformity and loss of function of the chest wall and the shoulder. Celsius.

  12. An in-depth stability analysis of nonuniform FDTD combined with novel local implicitization techniques

    Science.gov (United States)

    Van Londersele, Arne; De Zutter, Daniël; Vande Ginste, Dries

    2017-08-01

    This work focuses on efficient full-wave solutions of multiscale electromagnetic problems in the time domain. Three local implicitization techniques are proposed and carefully analyzed in order to relax the traditional time step limit of the Finite-Difference Time-Domain (FDTD) method on a nonuniform, staggered, tensor product grid: Newmark, Crank-Nicolson (CN) and Alternating-Direction-Implicit (ADI) implicitization. All of them are applied in preferable directions, alike Hybrid Implicit-Explicit (HIE) methods, as to limit the rank of the sparse linear systems. Both exponential and linear stability are rigorously investigated for arbitrary grid spacings and arbitrary inhomogeneous, possibly lossy, isotropic media. Numerical examples confirm the conservation of energy inside a cavity for a million iterations if the time step is chosen below the proposed, relaxed limit. Apart from the theoretical contributions, new accomplishments such as the development of the leapfrog Alternating-Direction-Hybrid-Implicit-Explicit (ADHIE) FDTD method and a less stringent Courant-like time step limit for the conventional, fully explicit FDTD method on a nonuniform grid, have immediate practical applications.

  13. Stabilization of Pb and As in soils by applying combined treatment with phosphates and ferrous iron.

    Science.gov (United States)

    Xenidis, Anthimos; Stouraiti, Christina; Papassiopi, Nymphodora

    2010-05-15

    The chemical immobilization of Pb and As in contaminated soil from Lavrion, Greece, using monocalcium phosphate and ferrous sulfate as stabilizing agents was investigated. Monocalcium phosphate was added to contaminated soil at PO(4) to Pb molar ratios equal to 0, 0.5, 1, 1.5 and 2.5, whereas ferrous sulfate was added at Fe to As molar ratios equal to 0, 2.5, 5, 10 and 20. Phosphates addition to contaminated soil decreased Pb leachability, but resulted in significant mobilization of As. Simultaneous immobilization of Pb and As was obtained only when soil was treated with mixtures of phosphates and ferrous sulfate. Arsenic uptake by plants was also seen to increase when soil was treated only with phosphates, but co-addition of ferrous sulfate was efficient in maintaining As phytoaccumulation at low levels. The addition of at least 1.5M/M phosphates and 10M/M iron sulfate to soil reduced the dissolved levels of Pb and As in the water extracts to values in compliance with the EU drinking water standards. However, both additives contributed in the acidification of soil, decreasing pH from 7.8 to values as low as 5.6 and induced the mobilization of pH sensitive elements, such as Zn and Cd. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  14. Photostability and moisture uptake properties of wood veneers coated with a combination of thin sol-gel films and light stabilizers

    Science.gov (United States)

    Mandla A. Tshabalala; Ryan Libert; Christian M. Schaller

    2011-01-01

    In recent years, there has been increased interest in the use of inorganic UV blocking nanoparticles for photostabilization of wood surfaces. Photostability and moisture uptake properties of wood veneers coated with a combination of hybrid inorganic-organic thin sol-gel films and organic light stabilizers was investigated. The light stabilizers were applied by brushing...

  15. Extended safe preservation period of foods of plant origin through combined technological methods

    International Nuclear Information System (INIS)

    Miteva, D.; Nacheva, I.; Dzhakova, A.; Tsvetkov, Tsv.

    2008-01-01

    The sublimation drying of fruits as an innovative technology for preservation their composition and enzyme activity is applied to various fruits: apricots, strawberries, plumbs, peaches and apples. The authors present the main methods of lyophilization as an original biotechnology for cryopreservation of fruits and afterwards are subjected to cold sterilization with 1.5 and 3 kGy doses of gamma irradiation. The combined application of both technologies provides safe and extended preservation of fresh fruits with high content of vitamins, mineral salts, maximum preserved enzyme system, aroma-tasty complex and microbiological purity

  16. Stability of Porous Platinum Nanoparticles: Combined In Situ TEM and Theoretical Study

    DEFF Research Database (Denmark)

    Chang, Shery L. Y.; Barnard, Amanda S.; Dwyer, Christian

    2012-01-01

    Porous platinum nanoparticles provide a route for the development of catalysts that use less platinum without sacrificing catalytic performance. Here, we examine porous platinum nanoparticles using a combination of in situ transmission electron microscopy and calculations based on a first-principles......-parametrized thermodynamic model. Our experimental observations show that the initially irregular morphologies of the as-sythesized porous nanoparticles undergo changes at high temperatures to morphologies having faceted external surfaces with voids present in the interior of the particles. The increasing size of stable...

  17. Combined rock slope stability and shallow landslide susceptibility assessment of the Jasmund cliff area (Rügen Island, Germany

    Directory of Open Access Journals (Sweden)

    A. Günther

    2009-05-01

    Full Text Available In this contribution we evaluated both the structurally-controlled failure susceptibility of the fractured Cretaceous chalk rocks and the topographically-controlled shallow landslide susceptibility of the overlying glacial sediments for the Jasmund cliff area on Rügen Island, Germany. We employed a combined methodology involving spatially distributed kinematical rock slope failure testing with tectonic fabric data, and both physically- and inventory-based shallow landslide susceptibility analysis. The rock slope failure susceptibility model identifies areas of recent cliff collapses, confirming its value in predicting the locations of future failures. The model reveals that toppling is the most important failure type in the Cretaceous chalk rocks of the area. The shallow landslide susceptibility analysis involves a physically-based slope stability evaluation which utilizes material strength and hydraulic conductivity data, and a bivariate landslide susceptibility analysis exploiting landslide inventory data and thematic information on ground conditioning factors. Both models show reasonable success rates when evaluated with the available inventory data, and an attempt was made to combine the individual models to prepare a map displaying both terrain instability and landslide susceptibility. This combination highlights unstable cliff portions lacking discrete landslide areas as well as cliff sections highly affected by past landslide events. Through a spatial integration of the rock slope failure susceptibility model with the combined shallow landslide assessment we produced a comprehensive landslide susceptibility map for the Jasmund cliff area.

  18. Combining active chilled beams and air-cleaning technologies to improve the indoor climate in offices

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Afshari, Alireza; Bergsøe, Niels Christian

    2013-01-01

    This project is part of a long-term research programme to study the possibilities of using efficient air-cleaning technologies to improve the indoor air quality in buildings. The purpose of this part of the project was to study the energy-saving potential of combining the cooling and cleaning of ...... than 5 Pa (0.104 Ibf /ft2). Furthermore, the measurement results of the combined system showed that adding the filter accelerated the removal rate of the particles by 2 h-1. However, the efficiency of the chilled beam in exchanging heat was reduced by 38%....

  19. Combining active chilled beams and air cleaning technologies to improve indoor climate in offices

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Afshari, Alireza; Bergsøe, Niels Christian

    2012-01-01

    This project is part of a long-term research programme studying the possibilities of using efficient air cleaning technologies to improve the indoor air quality in buildings. The purpose of this part of the project is to study energy-saving potential by combining cooling and cleaning of air in of....... Furthermore, the measurement results of the combined system showed that adding the filter accelerated the removal rate of the particles by 2 (h-1). However, the efficiency of the chilled beam in exchanging the heat reduced by 38%....

  20. Tibial slope correction combined with second revision ACL produces good knee stability and prevents graft rupture.

    Science.gov (United States)

    Dejour, David; Saffarini, Mo; Demey, Guillaume; Baverel, Laurent

    2015-10-01

    Revision ACL reconstruction requires careful analysis of failure causes particularly in cases of two previous graft ruptures. Intrinsic factors as excessive tibial slope or narrow femoral notch increase failure risks but are rarely addressed in revision surgery. The authors report outcomes, at minimum follow-up of 2 years, for second revision ACL reconstructions combined with tibial deflexion osteotomy for correction of excessive slope (>12°). Nine patients that underwent second revision ACL reconstruction combined with tibial deflexion osteotomy were retrospectively studied. The mean age was 30.3 ± 4.4 years (median 28; range 26-37), and mean follow-up was 4.0 ± 2.0 years (median 3.6; range 2.0-7.6). Autografts were harvested from the quadriceps tendon (n = 8) or hamstrings (n = 1), and tibial osteotomy was done by anterior closing wedge, without detachment of the patellar tendon, to obtain a slope of 3° to 5°. All patients had fused osteotomies, stable knees, and there were no intraoperative or postoperative complications. The mean posterior tibial slope decreased from 13.2° ± 2.6° (median 13°; range 12°-18°) preoperatively to 4.4° ± 2.3° (median 4°; range 2°-8°) postoperatively. The mean Lysholm score was 73.8 ± 5.8 (median 74; range 65-82), and the IKDC-SKF was 71.6 ± 6.1 (median 72.8; range 62.2-78.5). The satisfactory results of second revision ACL reconstruction combined with tibial deflexion osteotomy at minimum follow-up of 2 years suggest that tibia slope correction protects reconstructed ACL from fatigue failure in this study. The authors stress the importance of careful analysis failure causes prior to revision ACL reconstruction, and recommend correction of tibial slope if it exceeds 12°, to reduce the risks of graft retear. III.

  1. Combining Induced Pluripotent Stem Cells and Genome Editing Technologies for Clinical Applications.

    Science.gov (United States)

    Chang, Chia-Yu; Ting, Hsiao-Chien; Su, Hong-Lin; Jeng, Jing-Ren

    2018-01-01

    In this review, we introduce current developments in induced pluripotent stem cells (iPSCs), site-specific nuclease (SSN)-mediated genome editing tools, and the combined application of these two novel technologies in biomedical research and therapeutic trials. The sustainable pluripotent property of iPSCs in vitro not only provides unlimited cell sources for basic research but also benefits precision medicines for human diseases. In addition, rapidly evolving SSN tools efficiently tailor genetic manipulations for exploring gene functions and can be utilized to correct genetic defects of congenital diseases in the near future. Combining iPSC and SSN technologies will create new reliable human disease models with isogenic backgrounds in vitro and provide new solutions for cell replacement and precise therapies.

  2. Elastic stability of laminated, flat and curved, long rectangular plates subjected to combined inplane loads

    Science.gov (United States)

    Viswanathan, A. V.; Tamekuni, M.; Baker, L. L.

    1974-01-01

    A method is presented to predict theoretical buckling loads of long, rectangular flat and curved laminated plates with arbitrary orientation of orthotropic axes each lamina. The plate is subjected to combined inplane normal and shear loads. Arbitrary boundary conditions may be stipulated along the longitudinal sides of the plate. In the absence of inplane shear loads and extensional-shear coupling, the analysis is also applicable to finite length plates. Numerical results are presented for curved laminated composite plates with boundary conditions and subjected to various loadings. These results indicate some of the complexities involved in the numerical solution of the analysis for general laminates. The results also show that the reduced bending stiffness approximation when applied to buckling problems could lead to considerable error in some cases and therefore must be used with caution.

  3. Combining Brain–Computer Interfaces and Assistive Technologies: State-of-the-Art and Challenges

    Science.gov (United States)

    Millán, J. d. R.; Rupp, R.; Müller-Putz, G. R.; Murray-Smith, R.; Giugliemma, C.; Tangermann, M.; Vidaurre, C.; Cincotti, F.; Kübler, A.; Leeb, R.; Neuper, C.; Müller, K.-R.; Mattia, D.

    2010-01-01

    In recent years, new research has brought the field of electroencephalogram (EEG)-based brain–computer interfacing (BCI) out of its infancy and into a phase of relative maturity through many demonstrated prototypes such as brain-controlled wheelchairs, keyboards, and computer games. With this proof-of-concept phase in the past, the time is now ripe to focus on the development of practical BCI technologies that can be brought out of the lab and into real-world applications. In particular, we focus on the prospect of improving the lives of countless disabled individuals through a combination of BCI technology with existing assistive technologies (AT). In pursuit of more practical BCIs for use outside of the lab, in this paper, we identify four application areas where disabled individuals could greatly benefit from advancements in BCI technology, namely, “Communication and Control”, “Motor Substitution”, “Entertainment”, and “Motor Recovery”. We review the current state of the art and possible future developments, while discussing the main research issues in these four areas. In particular, we expect the most progress in the development of technologies such as hybrid BCI architectures, user–machine adaptation algorithms, the exploitation of users’ mental states for BCI reliability and confidence measures, the incorporation of principles in human–computer interaction (HCI) to improve BCI usability, and the development of novel BCI technology including better EEG devices. PMID:20877434

  4. Promoter library-based module combination (PLMC) technology for optimization of threonine biosynthesis in Corynebacterium glutamicum.

    Science.gov (United States)

    Wei, Liang; Xu, Ning; Wang, Yiran; Zhou, Wei; Han, Guoqiang; Ma, Yanhe; Liu, Jun

    2018-05-01

    Due to the lack of efficient control elements and tools, the fine-tuning of gene expression in the multi-gene metabolic pathways is still a great challenge for engineering microbial cell factories, especially for the important industrial microorganism Corynebacterium glutamicum. In this study, the promoter library-based module combination (PLMC) technology was developed to efficiently optimize the expression of genes in C. glutamicum. A random promoter library was designed to contain the putative - 10 (NNTANANT) and - 35 (NNGNCN) consensus motifs, and refined through a three-step screening procedure to achieve numerous genetic control elements with different strength levels, including fluorescence-activated cell sorting (FACS) screening, agar plate screening, and 96-well plate screening. Multiple conventional strategies were employed for further precise characterizations of the promoter library, such as real-time quantitative PCR, sodium dodecyl sulfate polyacrylamide gel electrophoresis, FACS analysis, and the lacZ reporter system. These results suggested that the established promoter elements effectively regulated gene expression and showed varying strengths over a wide range. Subsequently, a multi-module combination technology was created based on the efficient promoter elements for combination and optimization of modules in the multi-gene pathways. Using this technology, the threonine biosynthesis pathway was reconstructed and optimized by predictable tuning expression of five modules in C. glutamicum. The threonine titer of the optimized strain was significantly improved to 12.8 g/L, an approximate 6.1-fold higher than that of the control strain. Overall, the PLMC technology presented in this study provides a rapid and effective method for combination and optimization of multi-gene pathways in C. glutamicum.

  5. Combining different Technologies in a Funerary Archaeology content and language integrated Learning (CLIL) Course

    OpenAIRE

    Cignoni, Laura; Fornaciari, Gino

    2009-01-01

    The aim of this paper is to describe a project in which Italian undergraduate students at the Palaeopathology Division of Pisa University will attend a two-year Content and Language Integrated Learning (CLIL) course combining the study of funerary archaeology with English as vehicular language. At the presence of a subject and language teacher working together, the trainees will use different types of technology including devices such as electronic blackboards and Word applications with user-...

  6. Combined arthroscopically assisted coraco- and acromioclavicular stabilization of acute high-grade acromioclavicular joint separations.

    Science.gov (United States)

    Hann, Carmen; Kraus, Natascha; Minkus, Marvin; Maziak, Nina; Scheibel, Markus

    2018-01-01

    Due to high rate of persisting dynamic posterior translation (DPT) following isolated coracoclavicular double-button technique for reconstruction of the acromioclavicular (AC) joint reported in the literature, an additional acromioclavicular cerclage was added to the procedure. The aim of this study was to evaluate the clinical and radiological results of patients with high-grade AC-joint instability treated with a double TightRope technique with an additional percutaneous acromioclavicular cerclage. Fifty-nine patients (6 f/53 m; median age 38.3 (range 21.5-63.4 years) who sustained an acute high-grade AC-joint dislocation (Rockwood type V) were treated using the above-mentioned technique. At the final follow-up, the constant score (CS), the subjective shoulder value (SSV), the Taft score (TF) and the acromioclavicular joint instability score (ACJI) as well as bilateral anteroposterior stress views with 10 kg of axial load and bilateral modified Alexander views were obtained. At a median follow-up of 26.4 (range 20.3-61.0) months, 34 patients scored a median of 90 (33-100) points in the CS, 90 (25-100) % in the SSV, 11 (4-12) points in the TF and 87 (43-100) points in the ACJI. The coracoclavicular (CC) distance was 12.1 (6.5-19.8) mm and the CC difference 2.0 (0.0-11.0) mm. Two patients (5.8%) showed a complete DPT of the AC joint, and fourteen patients (41.1%) displayed a partial DPT. The overall revision rate was 11.7%. Two patients presented implant irritation, one patient a recurrent instability, and one patient suffered from a local infection. The arthroscopically assisted and image-intensifier-controlled double TightRope technique with an additional percutaneous acromioclavicular cerclage leads to good and excellent clinical results after a follow-up of 2 years. The incidence of persisting dynamic horizontal translation is lower compared to isolated coracoclavicular stabilization. Thus, we recommend using the double TightRope implant with an additional

  7. Inkjet printing for biosensor fabrication: combining chemistry and technology for advanced manufacturing.

    Science.gov (United States)

    Li, Jia; Rossignol, Fabrice; Macdonald, Joanne

    2015-06-21

    Inkjet printing is emerging at the forefront of biosensor fabrication technologies. Parallel advances in both ink chemistry and printers have led to a biosensor manufacturing approach that is simple, rapid, flexible, high resolution, low cost, efficient for mass production, and extends the capabilities of devices beyond other manufacturing technologies. Here we review for the first time the factors behind successful inkjet biosensor fabrication, including printers, inks, patterning methods, and matrix types. We discuss technical considerations that are important when moving beyond theoretical knowledge to practical implementation. We also highlight significant advances in biosensor functionality that have been realised through inkjet printing. Finally, we consider future possibilities for biosensors enabled by this novel combination of chemistry and technology.

  8. MINE WASTE TECHNOLOGY PROGRAM; PHOSPHATE STABILIZATION OF HEAVY METALS CONTAMINATED MINE WASTE YARD SOILS, JOPLIN, MISSOURI NPL SITE

    Science.gov (United States)

    This document summarizes the results of Mine Waste Technology Project 22-Phosphate Stabilization of Heavy Metals-Contaminated Mine Waste Yard Soils. Mining, milling, and smelting of ores near Joplin, Missouri, have resulted in heavy metal contamination of the area. The Joplin s...

  9. OVERVIEW OF THE HISTORY, PRESENT STATUS, AND FUTURE DIRECTION OF SOLIDIFICATION/STABILIZATION TECHNOLOGIES FOR HAZARDOUS WASTE TREATMENT

    Science.gov (United States)

    Solidification/stabilization (S/S) technology processes are currently being utilized in the United States to treat inorganic and organic hazardous waste and radioactive waste. These wastes are generated from operating industry or have resulted from the uncontrolled management of ...

  10. A Unique Master's Program in Combined Nuclear Technology and Nuclear Chemistry at Chalmers University of Technology, Sweden

    International Nuclear Information System (INIS)

    Skarnemark, Gunnar; Allard, Stefan; Ekberg, Christian; Nordlund, Anders

    2009-01-01

    The need for engineers and scientists who can ensure safe and secure use of nuclear energy is large in Sweden and internationally. Chalmers University of Technology is therefore launching a new 2-year master's program in Nuclear Engineering, with start from the autumn of 2009. The program is open to Swedish and foreign students. The program starts with compulsory courses dealing with the basics of nuclear chemistry and physics, radiation protection, nuclear power and reactors, nuclear fuel supply, nuclear waste management and nuclear safety and security. There are also compulsory courses in nuclear industry applications and sustainable energy futures. The subsequent elective courses can be chosen freely but there is also a possibility to choose informal tracks that concentrate on nuclear chemistry or reactor technology and physics. The nuclear chemistry track comprises courses in e.g. chemistry of lanthanides, actinides and transactinides, solvent extraction, radioecology and radioanalytical chemistry and radiopharmaceuticals. The program is finished with a one semester thesis project. This is probably a unique master program in the sense of its combination of deep courses in both nuclear technology and nuclear chemistry.

  11. Thermal degradation of sucralose: a combination of analytical methods to determine stability and chlorinated byproducts

    Science.gov (United States)

    de Oliveira, Diogo N.; de Menezes, Maico; Catharino, Rodrigo R.

    2015-04-01

    In the late years, much attention has been brought to the scientific community regarding the safety of sucralose and its industrial applications. Although it is the most used artificial sweetener in foods and pharmaceuticals, many questions still arise on its potential to form chlorinated byproducts in high temperatures, as demonstrated by several recent studies. In the present contribution, we use a combination of differential scanning calorimetry and thermogravimetric analysis coupled with infrared spectroscopy (DSC/TGA/IR), Hot-stage microscopy (HSM) and high-resolution mass spectrometry (HRMS) on samples submitted to water bath at mild temperatures to evaluate a broad spectrum of hazardous compounds formed in the degradation of this product. TGA/IR has revealed that there is effective decomposition in form of CO2 along with the formation of hydrogen chloride and other minor compounds. HSM results have provided accurate information, where the melting of the crystals was observed, followed by decomposition. Chlorinated derivatives, including polychlorinated aromatic hydrocarbons (PCAHs) were also confirmed by HRMS. These findings not only corroborate the suspected instability of sucralose to high temperatures, but also indicate that even exposed to mild conditions the formation of hazardous polychlorinated compounds is observed.

  12. A combined transcutaneous PO2-PCO2 electrode with electrochemical HCO3- stabilization.

    Science.gov (United States)

    Severinghaus, J W

    1981-10-01

    Combined transcutaneous PO2-PCO2 electrodes are described in which the interaction between the two electrodes due to OH- production at the O2 cathode has been eliminated. An anode of either anodized aluminum or platinum has been driven at a current equal to cathode current to force stoichiometric consumption of OH- at its rate of production. The AgCl reference electrode operates at zero current. O2 sensitivity was not significantly altered by electrolyte pH variation from 6.7 to 9.0 with variations by PCO2. These electrodes have been found stable both with and without spacers, and with electrolytes dissolved in 50-100% ethylene glycol. In 22 anesthetized patients, with electrode temperature of 43 degrees C (s refers to skin surface, a to arterial blood); PsO2 = 0.52PaO2 + 15 (range 54-300) (r = 0.66; Sy . x = 29.6; n = 46); and PsCO2 = 1.39PaCO2 + 2.1 (range 24-98) (r = 0.99; Sy . x = 2.28; n = 48).

  13. A Validated Stability-Indicating HPLC Method for Simultaneous Determination of Amoxicillin and Enrofloxacin Combination in an Injectable Suspension

    Directory of Open Access Journals (Sweden)

    Nidal Batrawi

    2017-02-01

    Full Text Available The combination of amoxicillin and enrofloxacin is a well-known mixture of veterinary drugs; it is used for the treatment of Gram-positive and Gram-negative bacteria. In the scientific literature, there is no high-performance liquid chromatography (HPLC-UV method for the simultaneous determination of this combination. The objective of this work is to develop and validate an HPLC method for the determination of this combination. In this regard, a new, simple and efficient reversed-phase HPLC method for simultaneous qualitative and quantitative determination of amoxicillin and enrofloxacin, in an injectable preparation with a mixture of inactive excipients, has been developed and validated. The HPLC separation method was performed using a reversed-phase (RP-C18e (250 mm × 4.0 mm, 5 μm column at room temperature, with a gradient mobile phase of acetonitrile and phosphate buffer containing methanol at pH 5.0, a flow rate of 0.8 mL/min and ultraviolet detection at 267 nm. This method was validated in accordance with the Food and Drug Administration (FDA and the International Conference on Harmonisation (ICH guidelines and showed excellent linearity, accuracy, precision, specificity, robustness, ruggedness, and system suitability results within the acceptance criteria. A stability-indicating study was also carried out and indicated that this method can also be used for purity and degradation evaluation of these formulations.

  14. A linguistic approach to solving of the problem of technological adjustment of combines

    Directory of Open Access Journals (Sweden)

    Lyudmila V. Borisova

    2017-06-01

    Full Text Available Introduction: The article deals with a linguistic approach to the technological adjustment of difficult harvesters in field conditions. The short characteristic of subject domain is provided. The place of the task of adjustment of the combine harvester working bodies in harvesting is considered. Various groups of signs of the considered task are allocated: external signs of violation of quality of work, regulated parameters of the machine, and parameters of technical condition. The numerical data characterizing interrelations between external signs and parameters of the machine are provided. Materials and Methods: A combine harvester is the difficult dynamic system functioning under constantly changing external conditions. This fact imposes characteristics on the used methods of technological adjustment. Quantitative and qualitative information is used to control harvesting. Availability of different types of uncertainty in considering semantic spaces of factors of the external environment and parameters of the machine allows offering the method of technological adjustment based on an indistinct logical conclusion for the solution of the task. Results: As the analysis result, the decision making methodology for indistinct environment conditions is adapted for the studied subject domain. The generalized scheme of indistinct management of process is offered to technological adjustment of the machine. Models of the studied semantic spaces are considered. Feasibility of use of deductive and inductive conclusions of decisions for various tasks of preliminary setup and adjustment of technological adjustments is shown. The formal and logical scheme of the decision making process based on indistinct expert knowledge is offered. The scheme includes the main stages of the task solution: fazzifikation, composition and defazzifikation. The question of the quantitative assessment of expert knowledge coordination is considered. The examples of the formulation

  15. Visibility and oxidation stability of hybrid-type copper mesh electrodes with combined nickel-carbon nanotube coating

    Science.gov (United States)

    Kim, Bu-Jong; Hwang, Young-Jin; Park, Jin-Seok

    2017-04-01

    Hybrid-type transparent conductive electrodes (TCEs) were fabricated by coating copper (Cu) meshes with carbon nanotube (CNT) via electrophoretic deposition, and with nickel (Ni) via electroplating. For the fabricated electrodes, the effects of the coating with CNT and Ni on their transmittance and reflectance in the visible-light range, electrical sheet resistance, and chromatic parameters (e.g., redness and yellowness) were characterized. Also, an oxidation stability test was performed by exposing the electrodes to air for 20 d at 85 °C and 85% temperature and humidity conditions, respectively. It was discovered that the CNT coating considerably reduced the reflectance of the Cu meshes, and that the Ni coating effectively protected the Cu meshes against oxidation. Furthermore, after the coating with CNT, both the redness and yellowness of the Cu mesh regardless of the Ni coating approached almost zero, indicating a natural color. The experiment results confirmed that the hybrid-type Cu meshes with combined Ni-CNT coating improved characteristics in terms of reflectance, sheet resistance, oxidation stability, and color, superior to those of the primitive Cu mesh, and also simultaneously satisfied most of the requirements for TCEs.

  16. Amphiphilic Imbalance and Stabilization of Block Copolymer Micelles on-Demand through Combinational Photo-Cleavage and Photo-Crosslinking.

    Science.gov (United States)

    Zhang, Xuan; Wang, Youpeng; Li, Guo; Liu, Zhaotie; Liu, Zhongwen; Jiang, Jinqiang

    2017-01-01

    An amphiphilic block copolymer of poly(ethylene oxide)-b-poly((N-methacryloxy phthalimide)-co-(7-(4-vinyl-benzyloxyl)-4-methylcoumarin)) (PEO 45 -b-P(MAPI 36 -co-VBC 4 )) is designed to improve the micellar stability during the photo-triggered release of hydrophobic cargoes. Analysis of absorption and emission spectra, solution transmittance, dynamic light scattering, and transmission electron microscopy supports that polymer micelles of PEO 45 -b-P(MAPI 36 -co-VBC 4 ) upon the combinational irradiation of 365 and 254 nm light can be solubilized through the photolysis of phthalimide esters and simultaneously crosslinked via the partially reversible photo-dimerization of coumarins. The photo-triggered release experiment shows that the leakage of doxorubicin molecules from crosslinked micelles can be predictably regulated by controlling the irradiation time of 365 and 254 nm light. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Generating a high brightness multi-kilowatt laser by dense spectral combination of VBG stabilized single emitter laser diodes

    Science.gov (United States)

    Fritsche, H.; Koch, Ralf; Krusche, B.; Ferrario, F.; Grohe, Andreas; Pflueger, S.; Gries, W.

    2014-05-01

    Generating high power laser radiation with diode lasers is commonly realized by geometrical stacking of diode bars, which results in high output power but poor beam parameter product (BPP). The accessible brightness in this approach is limited by the fill factor, both in slow and fast axis. By using a geometry that accesses the BPP of the individual diodes, generating a multi kilowatt diode laser with a BPP comparable to fiber lasers is possible. We will demonstrate such a modular approach for generating multi kilowatt lasers by combining single emitter diode lasers. Single emitter diodes have advantages over bars, mainly a simplified cooling, better reliability and a higher brightness per emitter. Additionally, because single emitters can be arranged in many different geometries, they allow building laser modules where the brightness of the single emitters is preserved. In order to maintain the high brightness of the single emitter we developed a modular laser design which uses single emitters in a staircase arrangement, then coupling two of those bases with polarization combination which is our basic module. Those modules generate up to 160 W with a BPP better than 7.5 mm*mrad. For further power scaling wavelength stabilization is crucial. The wavelength is stabilized with only one Volume Bragg Grating (VBG) in front of a base providing the very same feedback to all of the laser diodes. This results in a bandwidth of BPP better than 7.5 mm*mrad, which can easily coupled into a 100 μm fiber and 0.15 NA.

  18. Finding stability regions for preserving efficiency classification of variable returns to scale technology in data envelopment analysis

    Science.gov (United States)

    Zamani, P.; Borzouei, M.

    2016-12-01

    This paper addresses issue of sensitivity of efficiency classification of variable returns to scale (VRS) technology for enhancing the credibility of data envelopment analysis (DEA) results in practical applications when an additional decision making unit (DMU) needs to be added to the set being considered. It also develops a structured approach to assisting practitioners in making an appropriate selection of variation range for inputs and outputs of additional DMU so that this DMU be efficient and the efficiency classification of VRS technology remains unchanged. This stability region is simply specified by the concept of defining hyperplanes of production possibility set of VRS technology and the corresponding halfspaces. Furthermore, this study determines a stability region for the additional DMU within which, in addition to efficiency classification, the efficiency score of a specific inefficient DMU is preserved and also using a simulation method, a region in which some specific efficient DMUs become inefficient is provided.

  19. A multimedia adult literacy program: Combining NASA technology, instructional design theory, and authentic literacy concepts

    Science.gov (United States)

    Willis, Jerry W.

    1993-01-01

    For a number of years, the Software Technology Branch of the Information Systems Directorate has been involved in the application of cutting edge hardware and software technologies to instructional tasks related to NASA projects. The branch has developed intelligent computer aided training shells, instructional applications of virtual reality and multimedia, and computer-based instructional packages that use fuzzy logic for both instructional and diagnostic decision making. One outcome of the work on space-related technology-supported instruction has been the creation of a significant pool of human talent in the branch with current expertise on the cutting edges of instructional technologies. When the human talent is combined with advanced technologies for graphics, sound, video, CD-ROM, and high speed computing, the result is a powerful research and development group that both contributes to the applied foundations of instructional technology and creates effective instructional packages that take advantage of a range of advanced technologies. Several branch projects are currently underway that combine NASA-developed expertise to significant instructional problems in public education. The branch, for example, has developed intelligent computer aided software to help high school students learn physics and staff are currently working on a project to produce educational software for young children with language deficits. This report deals with another project, the adult literacy tutor. Unfortunately, while there are a number of computer-based instructional packages available for adult literacy instruction, most of them are based on the same instructional models that failed these students when they were in school. The teacher-centered, discrete skill and drill-oriented, instructional strategies, even when they are supported by color computer graphics and animation, that form the foundation for most of the computer-based literacy packages currently on the market may not

  20. The combination design for open and endoscopic surgery using fluorescence molecular imaging technology

    Science.gov (United States)

    Mao, Yamin; Jiang, Shixin; Ye, Jinzuo; An, Yu; Yang, Xin; Chi, Chongwei; Tian, Jie

    2015-03-01

    For clinical surgery, it is still a challenge to objectively determine tumor margins during surgery. With the development of medical imaging technology, fluorescence molecular imaging (FMI) method can provide real-time intraoperative tumor margin information. Furthermore, surgical navigation system based on FMI technology plays an important role for the aid of surgeons' precise tumor margin decision. However, detection depth is the most limitation exists in the FMI technique and the method convenient for either macro superficial detection or micro deep tissue detection is needed. In this study, we combined advantages of both open surgery and endoscopic imaging systems with FMI technology. Indocyanine green (ICG) experiments were performed to confirm the feasibility of fluorescence detection in our system. Then, the ICG signal was photographed in the detection area with our system. When the system connected with endoscope lens, the minimum quantity of ICG detected by our system was 0.195 ug. For aspect of C mount lens, the sensitivity of ICG detection with our system was 0.195ug. Our experiments results proved that it was feasible to detect fluorescence images with this combination method. Our system shows great potential in the clinical applications of precise dissection of various tumors

  1. Analysis of energetic and exergetic efficiency, and environmental benefits of biomass integrated gasification combined cycle technology.

    Science.gov (United States)

    Mínguez, María; Jiménez, Angel; Rodríguez, Javier; González, Celina; López, Ignacio; Nieto, Rafael

    2013-04-01

    The problem of the high carbon dioxide emissions linked to power generation makes necessary active research on the use of biofuels in gas turbine systems as a promising alternative to fossil fuels. Gasification of biomass waste is particularly of interest in obtaining a fuel to be run in gas turbines, as it is an efficient biomass-to-biofuel conversion process, and an integration into a combined cycle power plant leads to a high performance with regard to energetic efficiency. The goal of this study was to carry out an energetic, exergetic and environmental analysis of the behaviour of an integrated gasification combined cycle (IGCC) plant fuelled with different kinds of biomass waste by means of simulations. A preliminary economic study is also included. Although a technological development in gasification technology is necessary, the results of simulations indicate a high technical and environmental interest in the use of biomass integrated gasification combined cycle (BioIGCC) systems for large-scale power generation from biomass waste.

  2. The effective use of gas turbines and combined cycle technology in heat and electrical energy production

    International Nuclear Information System (INIS)

    Boehm, B.; Stark, E.

    1999-01-01

    The modernization of the energy industry in many countries is a real challenge for both, the policy makers as well as for the power industry. Especially, the efficient satisfaction of the heat and electrical demand of big cities will remain an interesting task for supply companies and hence for today engineers and economists, because the availability of natural gas from Russia and from other deposits owning countries for the decades to come, cogeneration by using modern gas turbines and combined cycle technologies is a key and corner stone of supply, not the least for its very low emission and small environmental loading. It is the intention of this paper, to demonstrate under resource to: 1) the high potential of natural gas-based cogeneration; 2) the high efficiency of gas turbines and combined cycle plants; 3) their flexibility to cover different demands; 4) the operational experience with gas turbines and combined cycle cogeneration plants; 5) the very good environmental behavior of gas turbines. Actually, the highest utilization of primary energy resources is afforded with natural gas and described technology. Future gradual rise of gas prices can bring about a shift from the present main application in high efficiency load plants to mid range load operation of cogeneration plants. (Author)

  3. Longitudinal Static Stability and wake visualization of high altitude long endurance aircraft developed in Bandung institute of technology

    Science.gov (United States)

    Irsyad Lukman, E.; Agoes Moelyadi, M.

    2018-04-01

    A High Altitude Long Endurance (HALE) Unamanned Aerial Vehicle (UAV) is currently being researched in Bandung Institute of Technology. The HALE is designed to be a pseudo-sattelite for information and communication purpose in Indonesia. This paper would present the longitudinal static stability of the aircraft that was analysed using DATCOM as well as simulation of the wing using ANSYS CFX. Result shows that the aircraft has acceptable stability and the wake from the wing at climbing condition cannot be ignored, however it does not affect the horizontal tail.

  4. Novel Direct Steelmaking by Combining Microwave, Electric Arc, and Exothermal Heating Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Xiaodi Huang; Dr. J. Y. Hwang

    2005-03-28

    Steel is a basic material broadly used by perhaps every industry and individual. It is critical to our nation's economy and national security. Unfortunately, the American steel industry is losing competitiveness in the world steel production field. There is an urgent need to develop the next generation of steelmaking technology for the American steel industry. Direct steelmaking through the combination of microwave, electric arc, and exothermal heating is a revolutionary change from current steelmaking technology. This technology can produce molten steel directly from a shippable agglomerate, consisting of iron oxide fines, powdered coal, and ground limestone. This technology is projected to eliminate many current intermediate steelmaking steps including coking, pellet sintering, blast furnace (BF) ironmaking, and basic oxygen furnace (BOF) steelmaking. This technology has the potential to (a) save up to 45% of the energy consumed by conventional steelmaking; (b) dramatically reduce the emission of CO{sub 2}, SO{sub 2}, NO{sub x}, VOCs, fine particulates, and air toxics; (c) substantially reduce waste and emission control costs; (d) greatly lower capital cost; and (e) considerably reduce steel production costs. This technology is based on the unique capability of microwaves to rapidly heat steelmaking raw materials to elevated temperature, then rapidly reduce iron oxides to metal by volumetric heating. Microwave heating, augmented with electric arc and exothermal reactions, is capable of producing molten steel. This technology has the components necessary to establish the ''future'' domestic steel industry as a technology leader with a strong economically competitive position in world markets. The project goals were to assess the utilization of a new steelmaking technology for its potential to achieve better overall energy efficiency, minimize pollutants and wastes, lower capital and operating costs, and increase the competitiveness of the

  5. On Singularities and Black Holes in Combination-Driven Models of Technological Innovation Networks.

    Directory of Open Access Journals (Sweden)

    Ricard Solé

    Full Text Available It has been suggested that innovations occur mainly by combination: the more inventions accumulate, the higher the probability that new inventions are obtained from previous designs. Additionally, it has been conjectured that the combinatorial nature of innovations naturally leads to a singularity: at some finite time, the number of innovations should diverge. Although these ideas are certainly appealing, no general models have been yet developed to test the conditions under which combinatorial technology should become explosive. Here we present a generalised model of technological evolution that takes into account two major properties: the number of previous technologies needed to create a novel one and how rapidly technology ages. Two different models of combinatorial growth are considered, involving different forms of ageing. When long-range memory is used and thus old inventions are available for novel innovations, singularities can emerge under some conditions with two phases separated by a critical boundary. If the ageing has a characteristic time scale, it is shown that no singularities will be observed. Instead, a "black hole" of old innovations appears and expands in time, making the rate of invention creation slow down into a linear regime.

  6. On Singularities and Black Holes in Combination-Driven Models of Technological Innovation Networks.

    Science.gov (United States)

    Solé, Ricard; Amor, Daniel R; Valverde, Sergi

    2016-01-01

    It has been suggested that innovations occur mainly by combination: the more inventions accumulate, the higher the probability that new inventions are obtained from previous designs. Additionally, it has been conjectured that the combinatorial nature of innovations naturally leads to a singularity: at some finite time, the number of innovations should diverge. Although these ideas are certainly appealing, no general models have been yet developed to test the conditions under which combinatorial technology should become explosive. Here we present a generalised model of technological evolution that takes into account two major properties: the number of previous technologies needed to create a novel one and how rapidly technology ages. Two different models of combinatorial growth are considered, involving different forms of ageing. When long-range memory is used and thus old inventions are available for novel innovations, singularities can emerge under some conditions with two phases separated by a critical boundary. If the ageing has a characteristic time scale, it is shown that no singularities will be observed. Instead, a "black hole" of old innovations appears and expands in time, making the rate of invention creation slow down into a linear regime.

  7. Radiation therapy patient education using VERT: combination of technology with human care.

    Science.gov (United States)

    Jimenez, Yobelli A; Lewis, Sarah J

    2018-05-13

    The Virtual Environment for Radiotherapy Training (VERT) system is a recently available tool for radiation therapy education. The majority of research regarding VERT-based education is focused on students, with a growing area of research being VERT's role in patient education. Because large differences in educational requirements exist between students and patients, focused resources and subsequent evaluations are necessary to provide solid justification for the unique benefits and challenges posed by VERT in a patient education context. This commentary article examines VERT's role in patient education, with a focus on salient visual features, VERT's ability to address some of the spatial challenges associated with RT patient education and how to combine technology with human care. © 2018 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Society of Medical Imaging and Radiation Therapy and New Zealand Institute of Medical Radiation Technology.

  8. A Study on Establishing National Technology Strategy of Fusion Energy Development: Combining PEST-SWOT Methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Han Soo; Choi, Won Jae; Tho, Hyun Soo; Kang, Dong Yup; Kim, In Chung [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    Nuclear fusion, the joining of light nuclei of hydrogen into heavier nuclei of helium, has potential environmental, safety and proliferation characteristics as an energy source. It can also, provide an adequate amount of fuel to power civilization for a long time compared to human history. It is, however, more challenging to convert to an energy source than nuclear fission. To overcome this, Korea enacted a law to promote the development of fusion as an energy source in 2007. In accordance with this law, the government will establish a promotion plan to develop fusion energy, including policy goals, a framework, strategies, infrastructure, funding, human resources, international cooperation and etc. This will be reviewed every five years. This paper is focused on the combining PEST (political, economic, social and technological) method with SWOT (strength, weakness, opportunity and threat) analysis, which is a prerequisite to form national fusion energy technology strategy

  9. A Study on Establishing National Technology Strategy of Fusion Energy Development: Combining PEST-SWOT Methodologies

    International Nuclear Information System (INIS)

    Chang, Han Soo; Choi, Won Jae; Tho, Hyun Soo; Kang, Dong Yup; Kim, In Chung

    2012-01-01

    Nuclear fusion, the joining of light nuclei of hydrogen into heavier nuclei of helium, has potential environmental, safety and proliferation characteristics as an energy source. It can also, provide an adequate amount of fuel to power civilization for a long time compared to human history. It is, however, more challenging to convert to an energy source than nuclear fission. To overcome this, Korea enacted a law to promote the development of fusion as an energy source in 2007. In accordance with this law, the government will establish a promotion plan to develop fusion energy, including policy goals, a framework, strategies, infrastructure, funding, human resources, international cooperation and etc. This will be reviewed every five years. This paper is focused on the combining PEST (political, economic, social and technological) method with SWOT (strength, weakness, opportunity and threat) analysis, which is a prerequisite to form national fusion energy technology strategy

  10. Externally-fired combined cycle: An effective coal fueled technology for repowering and new generation

    Energy Technology Data Exchange (ETDEWEB)

    Stoddard, L.E.; Bary, M.R. [Black and Veatch, Kansas City, MO (United States); Gray, K.M. [Pennsylvania Electric Co., Johnstown, PA (United States); LaHaye, P.G. [Hague International, South Portland, ME (United States)

    1995-06-01

    The Externally-Fired Combined Cycle (EFCC) is an attractive emerging technology for powering high efficiency combined gas and steam turbine cycles with coal or other ash bearing fuels. In the EFCC, the heat input to a gas turbine is supplied indirectly through a ceramic air heater. The air heater, along with an atmospheric coal combustor and ancillary equipment, replaces the conventional gas turbine combustor. A steam generator located downstream from the ceramic air heater and steam turbine cycle, along with an exhaust cleanup system, completes the combined cycle. A key element of the EFCC Development Program, the 25 MMBtu/h heat-input Kennebunk Test Facility (KTF), has recently begun operation. The KTF has been operating with natural gas and will begin operating with coal in early 1995. The US Department of Energy selected an EFCC repowering of the Pennsylvania Electric Company`s Warren Station for funding under the Clean Coal Technology Program Round V. The project focuses on repowering an existing 48 MW (gross) steam turbine with an EFCC power island incorporating a 30 MW gas turbine, for a gross power output of 78 MW and a net output of 72 MW. The net plant heat rate will be decreased by approximately 30% to below 9,700 Btu/kWh. Use of a dry scrubber and fabric filter will reduce sulfur dioxide (SO{sub 2}) and particulate emissions to levels under those required by the Clean Air Act Amendments (CAAA) of 1990. Nitrogen oxides (NO{sub x}) emissions are controlled by the use of staged combustion. The demonstration project is currently in the engineering phase, with startup scheduled for 1997. This paper discusses the background of the EFCC, the KTF, the Warren Station EFCC Clean Coal Technology Demonstration Project, the commercial plant concept, and the market potential for the EFCC.

  11. Welding of titanium and nickel alloy by combination of explosive welding and spark plasma sintering technologies

    Energy Technology Data Exchange (ETDEWEB)

    Malyutina, Yu. N., E-mail: iuliiamaliutina@gmail.com; Bataev, A. A., E-mail: bataev@adm.nstu.ru; Shevtsova, L. I., E-mail: edeliya2010@mail.ru [Novosibirsk State Technical University, Novosibirsk, 630073 (Russian Federation); Mali, V. I., E-mail: vmali@mail.ru; Anisimov, A. G., E-mail: anis@hydro.nsc.ru [Lavrentyev Institute of Hydrodynamics SB RAS, Novosibirsk, 630090 (Russian Federation)

    2015-10-27

    A possibility of titanium and nickel-based alloys composite materials formation using combination of explosive welding and spark plasma sintering technologies was demonstrated in the current research. An employment of interlayer consisting of copper and tantalum thin plates makes possible to eliminate a contact between metallurgical incompatible titanium and nickel that are susceptible to intermetallic compounds formation during their interaction. By the following spark plasma sintering process the bonding has been received between titanium and titanium alloy VT20 through the thin powder layer of pure titanium that is distinguished by low defectiveness and fine dispersive structure.

  12. A CSP plant combined with biomass CHP using ORC-technology in Bronderslev Denmark

    DEFF Research Database (Denmark)

    Perers, Bengt; Furbo, Simon; Yuan, Guofeng

    2017-01-01

    A new CSP plant combined with biomass CHP, using ORC technology, will be built and taken into operation in Bronderslev, Denmark during spring 2017. The price for Biomass is expected to increase with more and more use of this very limited energy source and then CSP will be cost effective in the long...... run, also in the Danish climate. Oil is used as heat transfer fluid instead of steam giving several advantages in this application for district heating at high latitudes. Total efficiencies and costs, competitive to PV plants. are expected....

  13. Combining technologies to create bioactive hybrid scaffolds for bone tissue engineering.

    Science.gov (United States)

    Nandakumar, Anandkumar; Barradas, Ana; de Boer, Jan; Moroni, Lorenzo; van Blitterswijk, Clemens; Habibovic, Pamela

    2013-01-01

    Combining technologies to engineer scaffolds that can offer physical and chemical cues to cells is an attractive approach in tissue engineering and regenerative medicine. In this study, we have fabricated polymer-ceramic hybrid scaffolds for bone regeneration by combining rapid prototyping (RP), electrospinning (ESP) and a biomimetic coating method in order to provide mechanical support and a physico-chemical environment mimicking both the organic and inorganic phases of bone extracellular matrix (ECM). Poly(ethylene oxide terephthalate)-poly(buthylene terephthalate) (PEOT/PBT) block copolymer was used to produce three dimensional scaffolds by combining 3D fiber (3DF) deposition, and ESP, and these constructs were then coated with a Ca-P layer in a simulated physiological solution. Scaffold morphology and composition were studied using scanning electron microscopy (SEM) coupled to energy dispersive X-ray analyzer (EDX) and Fourier Tranform Infrared Spectroscopy (FTIR). Bone marrow derived human mesenchymal stromal cells (hMSCs) were cultured on coated and uncoated 3DF and 3DF + ESP scaffolds for up to 21 d in basic and mineralization medium and cell attachment, proliferation, and expression of genes related to osteogenesis were assessed. Cells attached, proliferated and secreted ECM on all the scaffolds. There were no significant differences in metabolic activity among the different groups on days 7 and 21. Coated 3DF scaffolds showed a significantly higher DNA amount in basic medium at 21 d compared with the coated 3DF + ESP scaffolds, whereas in mineralization medium, the presence of coating in 3DF+ESP scaffolds led to a significant decrease in the amount of DNA. An effect of combining different scaffolding technologies and material types on expression of a number of osteogenic markers (cbfa1, BMP-2, OP, OC and ON) was observed, suggesting the potential use of this approach in bone tissue engineering.

  14. Acceleration of aged-landfill stabilization by combining partial nitrification and leachate recirculation: A field-scale study

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Jinwook [R& D Center, Samsung Engineering Co., Ltd., 415-10 Woncheon-dong, Youngtong-gu, Suwon, Gyeonggi-do 443-823 (Korea, Republic of); Kim, Seungjin; Baek, Seungcheon [Department of Civil and Environmental Engineering, Hanyang University, Sa 3-dong, Sangnok-gu, Ansan, Gyeonggi-do 426-791 (Korea, Republic of); Lee, Nam-Hoon [Department of Environmental & Energy Engineering, Anyang University, 22 Samdeok-ro, 37 Beon-gil, Manan-gu, Anyang, Gyeonggi-do 430-714 (Korea, Republic of); Park, Seongjun; Lee, Junghun; Lee, Heechang [Department of Civil and Environmental Engineering, Hanyang University, Sa 3-dong, Sangnok-gu, Ansan, Gyeonggi-do 426-791 (Korea, Republic of); Bae, Wookeun, E-mail: wkbae@hanyang.ac.kr [Department of Civil and Environmental Engineering, Hanyang University, Sa 3-dong, Sangnok-gu, Ansan, Gyeonggi-do 426-791 (Korea, Republic of)

    2015-03-21

    Highlights: • To solve the drawbacks (NH{sub 4}{sup +} accumulation) of leachate recirculation, ex-situ SBR was applied. • Produced NO{sub 2}{sup −} was recirculated and denitrified to N{sub 2} in landfill with insufficient carbon source. • Despite the inhibition of methanogenesis by DO and nitrate, CH{sub 4} fraction eventually increased. - Abstract: Leachate recirculation for rapid landfill stabilization can result in the accumulation of high-strength ammonium. An on-site sequencing batch reactor (SBR) was therefore, applied to oxidize the ammonium to nitrite, which was then recirculated to the landfill for denitrification to nitrogen gas. At relatively higher ammonium levels, nitrite accumulated well in the SBR; the nitrite was denitrified stably in the landfill, despite an insufficient biodegradable carbon source in the leachate. As the leachate was recirculated, the methane and carbon dioxide contents produced from the landfill fluctuated, implying that the organic acids and hydrogen produced in the acid production phase acted as the carbon source for denitrification in the landfill. Leachate recirculation combined with ex-situ partial nitrification of the leachate may enhance the biodegradation process by: (a) removing the nitrogen that is contained with the leachate, and (b) accelerating landfill stabilization, because the biodegradation efficiency of landfill waste is increased by supplying sufficient moisture and its byproducts are used as the carbon source for denitrification. In addition, partial nitrification using an SBR has advantages for complete denitrification in the landfill, since the available carbon source is in short supply in aged landfills.

  15. Innovative Ingredients and Emerging Technologies for Controlling Ice Recrystallization, Texture, and Structure Stability in Frozen Dairy Desserts: A Review.

    Science.gov (United States)

    Soukoulis, Christos; Fisk, Ian

    2016-11-17

    Over the past decade, ice cream manufacturers have developed a strong understanding of the functionality of key ingredients and processing, developing effective explanations for the link between structure forming agents, stability mechanisms, and perceived quality. Increasing demand for products perceived as healthier/more natural with minimal processing has identified a number of new tools to improve quality and storage stability of frozen dairy desserts. Ingredients such as dietary fiber, polysaccharides, prebiotics, alternate sweeteners, fat sources rich in unsaturated fatty acids and ice strucsturing proteins (ISP) have been successfully applied as cryoprotective, texturizing, and structuring agents. Emerging minimal processing technologies including hydrostatic pressure processing, ultrasonic or high pressure assisted freezing, low temperature extrusion and enzymatically induced biopolymers crosslinking have been evaluated for their ability to improve colloidal stability, texture and sensory quality. It is therefore timely for a comprehensive review.

  16. Effectiveness of elastic band-type ankle–foot orthoses on postural control in poststroke elderly patients as determined using combined measurement of the stability index and body weight-bearing ratio

    Directory of Open Access Journals (Sweden)

    Kim JH

    2015-11-01

    Full Text Available Jong Hyun Kim, Woo Sang Sim, Byeong Hee Won Usability Evaluation Technology Center, Advanced Biomedical and Welfare R&D Group, Korea Institute of Industrial Technology, Cheonan-si, Chungcheongnam-do, South Korea Purpose: Poor recovery of postural stability poststroke is the primary cause of impairment in activities and social participation in elderly stroke survivors. The purpose of our study was to experimentally evaluate the effectiveness of our new elastic ankle–foot orthosis (AFO, compared to a traditional AFO fabricated with hard plastic, in improving postural stability in elderly chronic stroke survivors. Patients and methods: Postural stability was evaluated in ten chronic stroke patients, 55.7±8.43 years old. Postural stability was evaluated using the standardized methods of the Biodex Balance System combined with a foot pressure system, under three experimental conditions, no AFO, rigid plastic AFO, and elastic AFO (E-AFO. The following dependent variables of postural stability were analyzed: plantar pressure under the paretic and nonparetic foot, area of the center of balance (COB and % time spent in each location, distance traveled by the COB away from the body center, distance traveled by the center of pressure, and calculated index of overall stability, as well as indices anterior–posterior and medial–lateral stability. Results: Both AFO designs improved all indices of postural stability. Compared to the rigid plastic AFO, the E-AFO produced additional positive effects in controlling anterior–posterior body sway, equalizing weight bearing through the paretic and nonparetic limbs, and restraining the displacement of the center of pressure and of the COB. Conclusion: Based on our outcomes, we recommend the prescription of E-AFOs as part of a physiotherapy rehabilitation program to promote recovery of postural stability poststroke. When possible, therapeutic outcomes should be documented using the Biodex Balance System and

  17. Influence of Casein-Phospholipid Combinations as Emulsifier on the Physical and Oxidative Stability of Fish Oil-in-Water Emulsions

    DEFF Research Database (Denmark)

    García Moreno, Pedro Jesús; Horn, Anna Frisenfeldt; Jacobsen, Charlotte

    2014-01-01

    The objective of this study was to investigate the influence of casein (0.3% w/w) and phospholipid (0.5% w/w) emulsifier combinations on the physical and oxidative stability of 10% fish oil-in-water emulsions at pH 7. For that purpose, three phospholipids were evaluated, namely, lecithin (LC......), phosphatidylcholine (PC), and phosphatidylethanolamine (PE). The emulsion stabilized with LC showed the best physical stability having the most negative zeta potential and the lowest mean droplet size. In addition, this emulsion was also the least oxidized in terms of peroxide value and concentration of the volatile...

  18. Combination of struvite pyrolysate recycling with mixed-base technology for removing ammonium from fertilizer wastewater.

    Science.gov (United States)

    Yu, Rongtai; Geng, Jinju; Ren, Hongqiang; Wang, Yanru; Xu, Ke

    2012-11-01

    Removal of ammonium from wastewater via struvite (MAP) pyrolysate recycling combined with a mixed-base NaOH/Mg(OH)(2) technology was investigated, and the phosphate and magnesium concentration in the supernatant were measured. The optimal parameters for acidolysis were a pH of 1; temperature of 120°C and time of 2h. The presence of derivatives of amorphous magnesium hydrogen phosphate (MgHPO(4)), namely magnesium phosphate (Mg(3)(PO(4))(2)) and magnesium pyrophosphate (Mg(2)P(2)O(7)) were verified by experiment. The ammonium removal ratio in this combined mixed-base technology was 96.8% in the first cycle, 80.6% in the second, and 81.0% after acidolysis. The phosphate and magnesium ions concentration in the supernatant were about 1mg/L and 40 mg/L, respectively. The grain size of MAP was 1.52 nm without seeding and 1.79 nm with seeding, and the growth rate of MAP was 17.6%. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. A Framework for Successful Research Experiences in the Classroom: Combining the Power of Technology and Mentors

    Science.gov (United States)

    Graff, Paige Valderrama; Stefanov, William L.; Willis, Kim; Runco, Susan; McCollum, Tim; Lindgren, Charles F.; Baker, Marshalyn; Mailhot, Michele

    2011-01-01

    Authentic research opportunities in the classroom are most impactful when they are student-driven and inquiry-based. These experiences are even more powerful when they involve technology and meaningful connections with scientists. In today's classrooms, activities are driven by state required skills, education standards, and state mandated testing. Therefore, programs that incorporate authentic research must address the needs of teachers. NASA's Expedition Earth and Beyond (EEAB) Program has developed a framework that addresses teacher needs and incorporates the use of technology and access to mentors to promote and enhance authentic research in the classroom. EEAB is a student involvement program that facilitates student investigations of Earth or planetary comparisons using NASA data. To promote student-led research, EEAB provides standards-aligned, inquiry-based curricular resources, an implementation structure to facilitate research, educator professional development, and ongoing support. This framework also provides teachers with the option to incorporate the use of technology and connect students with a mentor, both of which can enrich student research experiences. The framework is structured by a modeled 9-step process of science which helps students organize their research. With more schools gaining increased access to technology, EEAB has created an option to help schools take advantage of students' interest and comfort with technology by leveraging the use of available technologies to enhance student research. The use of technology not only allows students to collaborate and share their research, it also provides a mechanism for them to work with a mentor. This framework was tested during the 2010/2011 school year. Team workspaces hosted on Wikispaces for Educators allow students to initiate their research and refine their research question initially without external input. This allows teams to work independently and rely on the skills and interests of

  20. A Framework for Successful Research Experiences in the Classroom: Combining the Power of Technology and Mentors

    Science.gov (United States)

    Graff, P. V.; Stefanov, W. L.; Willis, K.; Runco, S.; McCollum, T.; Lindgren, C. F.; Baker, M.; Mailhot, M.

    2011-12-01

    Authentic research opportunities in the classroom are most impactful when they are student-driven and inquiry-based. These experiences are even more powerful when they involve technology and meaningful connections with scientists. In today's classrooms, activities are driven by state required skills, education standards, and state mandated testing. Therefore, programs that incorporate authentic research must address the needs of teachers. NASA's Expedition Earth and Beyond (EEAB) Program has developed a framework that addresses teacher needs and incorporates the use of technology and access to mentors to promote and enhance authentic research in the classroom. EEAB is a student involvement program that facilitates student investigations of Earth or planetary comparisons using NASA data. To promote student-led research, EEAB provides standards-aligned, inquiry-based curricular resources, an implementation structure to facilitate research, educator professional development, and ongoing support. This framework also provides teachers with the option to incorporate the use of technology and connect students with a mentor, both of which can enrich student research experiences. The framework is structured by a modeled 9-step process of science which helps students organize their research. With more schools gaining increased access to technology, EEAB has created an option to help schools take advantage of students' interest and comfort with technology by leveraging the use of available technologies to enhance student research. The use of technology not only allows students to collaborate and share their research, it also provides a mechanism for them to work with a mentor. This framework was tested during the 2010/2011 school year. Team workspaces hosted on Wikispaces for Educators allow students to initiate their research and refine their research question initially without external input. This allows teams to work independently and rely on the skills and interests of

  1. Combining Frequency Doubling Technology Perimetry and Scanning Laser Polarimetry for Glaucoma Detection.

    Science.gov (United States)

    Mwanza, Jean-Claude; Warren, Joshua L; Hochberg, Jessica T; Budenz, Donald L; Chang, Robert T; Ramulu, Pradeep Y

    2015-01-01

    To determine the ability of frequency doubling technology (FDT) and scanning laser polarimetry with variable corneal compensation (GDx-VCC) to detect glaucoma when used individually and in combination. One hundred ten normal and 114 glaucomatous subjects were tested with FDT C-20-5 screening protocol and the GDx-VCC. The discriminating ability was tested for each device individually and for both devices combined using GDx-NFI, GDx-TSNIT, number of missed points of FDT, and normal or abnormal FDT. Measures of discrimination included sensitivity, specificity, area under the curve (AUC), Akaike's information criterion (AIC), and prediction confidence interval lengths. For detecting glaucoma regardless of severity, the multivariable model resulting from the combination of GDx-TSNIT, number of abnormal points on FDT (NAP-FDT), and the interaction GDx-TSNIT×NAP-FDT (AIC: 88.28, AUC: 0.959, sensitivity: 94.6%, specificity: 89.5%) outperformed the best single-variable model provided by GDx-NFI (AIC: 120.88, AUC: 0.914, sensitivity: 87.8%, specificity: 84.2%). The multivariable model combining GDx-TSNIT, NAP-FDT, and interaction GDx-TSNIT×NAP-FDT consistently provided better discriminating abilities for detecting early, moderate, and severe glaucoma than the best single-variable models. The multivariable model including GDx-TSNIT, NAP-FDT, and the interaction GDx-TSNIT×NAP-FDT provides the best glaucoma prediction compared with all other multivariable and univariable models. Combining the FDT C-20-5 screening protocol and GDx-VCC improves glaucoma detection compared with using GDx or FDT alone.

  2. Combined heat and power in Dutch greenhouses: A case study of technology diffusion

    International Nuclear Information System (INIS)

    Veen, Reinier A.C. van der; Kasmire, Julia

    2015-01-01

    This paper presents a case study of the rapid diffusion of combined heat and power (CHP) units through the Dutch greenhouse horticulture sector between 2003 and 2009 in order to gain new insights regarding technology transitions. We present a sectoral diffusion analysis framework, which we apply to identify and examine developments in technical, economic, institutional, cultural and ecological domains that all contributed to an emergent and thorough CHP diffusion in the Dutch greenhouse sector. Five identified key drivers behind the CHP diffusion are the opening of the energy market in 2002, the high spark spread during the transition period, the compatibility of output of a CHP unit with greenhouse demand, the flexibility provided by heat buffers, and the cooperative and competitive greenhouse sector culture. We conclude that policies to stimulate or steer technology diffusion will benefit from an in-depth analysis of domain interactions and company decision-making processes. Such an in-depth analysis makes for well informed and targeted policies that are better able to steer an industrial sector effectively and in a socially desired direction. - Highlights: • We present a sectoral diffusion analysis framework. • We describe the case of the diffusion of cogeneration (CHP) in Dutch greenhouses. • We extract five key drivers of CHP diffusion in the Dutch greenhouse sector. • The case shows how technology diffusion emerges from co-evolutionary mechanisms. • We conclude that a co-evolutionary sectoral analysis will inform innovation policy.

  3. Application of the combinative particle size reduction technology H 42 to produce fast dissolving glibenclamide tablets.

    Science.gov (United States)

    Salazar, Jaime; Müller, Rainer H; Möschwitzer, Jan P

    2013-07-16

    Standard particle size reduction techniques such as high pressure homogenization or wet bead milling are frequently used in the production of nanosuspensions. The need for micronized starting material and long process times are their evident disadvantages. Combinative particle size reduction technologies have been developed to overcome the drawbacks of the standard techniques. The H 42 combinative technology consists of a drug pre-treatment by means of spray-drying followed by standard high pressure homogenization. In the present paper, spray-drying process parameters influencing the diminution effectiveness, such as drug and surfactant concentration, were systematically analyzed. Subsequently, the untreated and pre-treated drug powders were homogenized for 20 cycles at 1500 bar. For untreated, micronized glibenclamide, the particle size analysis revealed a mean particle size of 772 nm and volume-based size distribution values of 2.686 μm (d50%) and 14.423 μm (d90%). The use of pre-treated material (10:1 glibenclamide/docusate sodium salt ratio spray-dried as ethanolic solution) resulted in a mean particle size of 236 nm and volume-based size distribution values of 0.131 μm (d50%) and 0.285 μm (d90%). These results were markedly improved compared to the standard process. The nanosuspensions were further transferred into tablet formulations. Wet granulation, freeze-drying and spray-drying were investigated as downstream methods to produce dry intermediates. Regarding the dissolution rate, the rank order of the downstream processes was as follows: Spray-drying>freeze-drying>wet granulation. The best drug release (90% within 10 min) was obtained for tablets produced with spray-dried nanosuspension containing 2% mannitol as matrix former. In comparison, the tablets processed with micronized glibenclamide showed a drug release of only 26% after 10 min. The H 42 combinative technology could be successfully applied in the production of small drug nanocrystals. A

  4. Combining communication technology utilization and organizational innovation: evidence from Canadian healthcare decision makers.

    Science.gov (United States)

    Jbilou, Jalila; Landry, Réjean; Amara, Nabil; El Adlouni, Salaheddine

    2009-08-01

    Information and Communication Technology (ICT) and Organizational Innovation (OI) are seen as the miracle of post-modernity in organizations. In this way, they are supposed to resolve most organizational problems, efficiently and rapidly. OI is highly dependent on the capacity and the investment in knowledge management (internal and external) to support decision making process and to implement significant changes. We know what explains ICT utilization (ICTU) and what determines OI development (OID) in healthcare services. Moreover, the literature tends to link ICTU to OID and vice versa. However, this dependency has never been explored empirically through the lens of roles combination. To identify the existing combined roles profiles of ICTU and OID among healthcare decision makers and determine factors of the shift from a profile to another. We did the following: (1) a structured review of the literature on healthcare management by focusing on ICTU and OID which allowed us to build two indexes and a comprehensive framework; (2) a copula methodology to identify with high precision the thresholds for ICTU and OID; and (3) a cross-sectional study based on a survey done with a sample of 942 decision makers from Canadian healthcare organizations through a multinomial logit model to identify determinants of the shift. ICTU and OID are correlated at 22% (Kendal's Tau). The joint distribution (combination) of ICTU and OID shows that four major profiles exist among decision makers in Canadian healthcare organizations: the traditional decision maker, the innovative decision maker, the technologic decision maker and the contemporary decision maker. We found out that classic factors act as barriers to the shift from one profile to the desired profile (from 1 to 4, from 2 to 4 and from 3 to 4). We have identified that the attitude toward research and relational capital are transversal barriers of shift. We have also found that some factors have a specific impact such as

  5. Studies on the treatment efficiency of sediment phosphorus with a combined technology of PCFM and submerged macrophytes

    International Nuclear Information System (INIS)

    Zhang, Yi; He, Feng; Xia, Shibin; Zhou, Qiaohong; Wu, Zhenbin

    2015-01-01

    The removal efficiency of sediment phosphorus (P) in all fractions with a combined technology of porous ceramic filter media (PCFM) and submerged macrophytes was studied in Donghu Lake, Wuhan, China. The adsorption kinetic models of the sediment P in all fractions on PCFM could be described well by a power function equations (Q t  = k · t a , 0 < a < 1). The P removal capacity of the combination of PCFM and Potamogeton crispus, a submerged macrophyte, was higher for all P forms than that of the combination of PCFM and another macrophyte, Vallisneria spiralis. This study suggested that the combination of PCFM and macrophytes could achieve a synergetic sediment P removal because the removal rates of the combinations were higher than the sum of that of PCFM and macrophytes used separately. The combined technology could be further applied to treat internal P loading in eutrophic waters. - Highlights: • PCFM were tested as novel sorbents for sediment P in all fractions removal. • Adsorption kinetic models of sediment P on PCFM could be described by power function equations. • Combination of PCFM and macrophytes could achieve a synergetic sediment P removal. • Combined technology could be further applied to treat internal P loading in eutrophic waters. - The combination of PCFM and macrophytes could achieve a synergetic sediment P removal because the removal rates of the combinations were higher than the sum of that used separately.

  6. An update technology for integrated biomass gasification combined cycle power plant

    International Nuclear Information System (INIS)

    Bhattacharya, P.; Dey, S.

    2014-01-01

    A discussion is presented on the technical analysis of a 6.4 M W_e integrated biomass gasification combined cycle (IBGCC) plant. It features three numbers of downdraft biomass gasifier systems with suitable gas clean-up trains, three numbers of internal combustion (IC) producer gas engines for producing 5.85 MW electrical power in open cycle and 550 kW power in a bottoming cycle using waste heat. Comparing with IC gas engine single cycle systems, this technology route increases overall system efficiency of the power plant, which in turn improves plant economics. Estimated generation cost of electricity indicates that mega-watt scale IBGCC power plants can contribute to good economies of scale in India. This paper also highlight's the possibility of activated carbon generation from the char, a byproduct of gasification process, and use of engine's jacket water heat to generate chilled water through VAM for gas conditioning. (author)

  7. Combined effects of petrographic and technological parameters on strength of porous coke substance

    Energy Technology Data Exchange (ETDEWEB)

    Dinel' t, V.M.; Shkoller, M.B.; Stankevich, A.S.; Korchuganova, G.S.

    1983-01-01

    A laboratory study was undertaken to study the combined effects of the basic petrographic characteristics of Kuzbas coal blends and the technological carbonization parameters on the structural strength of the porous coke. Strength tests were carried out on the original coke and the products of partial gasification with carbon dioxide under conditions simulating those inside blast furnaces. Properties of the 14 samples of Kuzbas coals and composition of the four coal blends made from them are listed. It was concluded that the structural strength of coke was most strongly influenced by the average reflectance index and bulk density of the charge. Also, charge compaction can largely offset the adverse influence of petrographic heterogeneity on the strength of the coke. 10 references, 3 tables.

  8. SELECTING WORKING TEAMS FOR INFORMATION TECHNOLOGY OUTSOURCING PROJECTS THROUGH A COMBINATION OF METHODOLOGIES

    Directory of Open Access Journals (Sweden)

    María Alejandra Castellini

    Full Text Available ABSTRACT This paper deals with a problem that Information Technology outsourcing suppliers generally face when selecting a working team technically capable for specific roles in software development projects. A combination of methodologies, interactively integrated, is proposed. They are Soft System Methodology to structure the problem, Repertory Grid for individual interviews and elicitation of the selection criteria, DRV Processes to assess the candidates and to generate knowledge and consensus on the selection process and Linear Programming to assign people to each position. This multimethodology allowed finding a more comprehensive solution than that initially requested by the company, since it helped to establish the necessary transformations for the selection model to operate in the right way, set the competencies to be considered as selection criteria, develop a consensus estimate of the weighted criteria, and award global values to candidates, optimizing the assignment of roles in the group for the project.

  9. Financial stability, wealth effects and optimal macroeconomic policy combination in the United Kingdom: A new-Keynesian dynamic stochastic general equilibrium framework

    Directory of Open Access Journals (Sweden)

    Muhammad Ali Nasir

    2016-12-01

    Full Text Available This study derives an optimal macroeconomic policy combination for financial sector stability in the United Kingdom by employing a New Keynesian Dynamic Stochastic General Equilibrium (NK-DSGE framework. The empirical results obtained show that disciplined fiscal and accommodative monetary policies stance is optimal for financial sector stability. Furthermore, fiscal indiscipline countered by contractionary monetary stance adversely affects financial sector stability. Financial markets, e.g. stocks and Gilts show a short-term asymmetric response to macroeconomic policy interaction and to each other. The asymmetry is a reflection of portfolio adjustment. However in the long-run, the responses to suggested optimal policy combination had homogenous effects and there was evidence of co-movement in the stock and Gilt markets.

  10. Three-dimensional evaluation of postural stability in Parkinson's disease with mobile technology.

    Science.gov (United States)

    Ozinga, Sarah J; Koop, Mandy Miller; Linder, Susan M; Machado, Andre G; Dey, Tanujit; Alberts, Jay L

    2017-01-01

    Postural instability is a hallmark of Parkinson's disease. Objective metrics to characterize postural stability are necessary for the development of treatment algorithms to aid in the clinical setting. The aim of this project was to validate a mobile device platform and resultant three-dimensional balance metric that characterizes postural stability. A mobile Application was developed, in which biomechanical data from inertial sensors within a mobile device were processed to characterize movement of center of mass in the medial-lateral, anterior-posterior and trunk rotation directions. Twenty-seven individuals with Parkinson's disease and 27 age-matched controls completed various balance tasks. A postural stability metric quantifying the amplitude (peak-to-peak) of sway acceleration in each movement direction was compared between groups. The peak-to-peak value in each direction for each individual with Parkinson's disease across all trials was expressed as a normalized value of the control data to identify individuals with severe postural instability, termed Cleveland Clinic-Postural Stability Index. In all conditions, the balance metric for peak-to-peak was significantly greater in Parkinson's disease compared to controls (p mobile device sensors, provides a rapid and systematic metric for quantifying postural stability in Parkinson's disease.

  11. Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: physical characterization, redispersibility, and dissolution.

    Science.gov (United States)

    He, Wei; Lu, Yi; Qi, Jianping; Chen, Lingyun; Yin, Lifang; Wu, Wei

    2013-01-01

    Drug nanosuspensions are very promising for enhancing the dissolution and bioavailability of drugs that are poorly soluble in water. However, the poor stability of nanosuspensions, reflected in particle growth, aggregation/agglomeration, and change in crystallinity state greatly limits their applications. Solidification of nanosuspensions is an ideal strategy for addressing this problem. Hence, the present work aimed to convert drug nanosuspensions into pellets using fluid-bed coating technology. Indomethacin nanosuspensions were prepared by the precipitation-ultrasonication method using food proteins (soybean protein isolate, whey protein isolate, β-lactoglobulin) as stabilizers. Dried nanosuspensions were prepared by coating the nanosuspensions onto pellets. The redispersibility, drug dissolution, solid-state forms, and morphology of the dried nanosuspensions were evaluated. The mean particle size for the nanosuspensions stabilized using soybean protein isolate, whey protein isolate, and β-lactoglobulin was 588 nm, 320 nm, and 243 nm, respectively. The nanosuspensions could be successfully layered onto pellets with high coating efficiency. Both the dried nanosuspensions and nanosuspensions in their original amorphous state and not influenced by the fluid-bed coating drying process could be redispersed in water, maintaining their original particle size and size distribution. Both the dried nanosuspensions and the original drug nanosuspensions showed similar dissolution profiles, which were both much faster than that of the raw crystals. Fluid-bed coating technology has potential for use in the solidification of drug nanosuspensions.

  12. Global warming impacts of CFC alternative technologies: Combining fluorocarbon and CO2 effects

    International Nuclear Information System (INIS)

    Fairchild, P.D.; Fischer, S.K.; Hughes, P.J.

    1992-01-01

    Chlorofluorocarbons (CFCs) are on their way out, due to their role in stratospheric ozone depletion and the related international Montreal Protocol agreement and various national phaseout timetables. As the research, engineering development, and manufacturing investment decisions have ensued to prepare for this transition away from CFCs, the climate change issue has emerged and there has recently been increased attention on the direct global warming potential (GWP) of the fluorocarbon alternatives as greenhouse gases. However, there has been less focus on the indirect global warming effect arising from end-use energy changes and associated CO 2 emissions. A study was undertaken to address these combined global warming effects. A concept of Total Equivalent Warming Impact (TEWI) was developed for combining the direct and indirect effects and was used for evaluating CFC-replacement options available in the required CFC transition time frame. Analyses of industry technology surveys indicate that CFC-user industries have made substantial progress toward near-equal energy efficiency with many HCFC/HFC alternatives. The findings also bring into question the relative importance of the direct effect in many applications and stress energy efficiency when searching for suitable CFC alternatives. For chillers, household refrigerators, and unitary air-conditioning or heat pump equipment, changes in efficiency of only 2--5% would have a greater effect on future TEWI than completely eliminating the direct effect

  13. Suspensions Plasma Spraying of Ceramics with Hybrid Water-Stabilized Plasma Technology

    Czech Academy of Sciences Publication Activity Database

    Mušálek, Radek; Medřický, Jan; Tesař, T.; Kotlan, Jiří; Pala, Zdeněk; Lukáč, František; Chráska, Tomáš; Curry, N.

    2017-01-01

    Roč. 26, 1-2 (2017), s. 37-46 ISSN 1059-9630. [ISTC 2016: International Thermal Spray Conference. Shanghai, 10.05.2016-12.05.2016] R&D Projects: GA ČR GA15-12145S Institutional support: RVO:61389021 Keywords : alumina * ceramics * dense * hybrid plasma torch * suspension plasma spraying * water-stabilized plasma * yttria-stabilized zirconia (YSZ) Subject RIV: JK - Corrosion ; Surface Treatment of Materials OBOR OECD: Coating and films Impact factor: 1.488, year: 2016 http://link.springer.com/article/10.1007/s11666-016-0493-6

  14. Integrated gasification gas combined cycle plant with membrane reactors: Technological and economical analysis

    International Nuclear Information System (INIS)

    Amelio, Mario; Morrone, Pietropaolo; Gallucci, Fausto; Basile, Angelo

    2007-01-01

    In the present work, the capture and storage of carbon dioxide from the fossil fuel power plant have been considered. The main objective was to analyze the thermodynamic performances and the technological aspects of two integrated gasification gas combined cycle plants (IGCC), as well as to give a forecast of the investment costs for the plants and the resulting energy consumptions. The first plant considered is an IGCC* plant (integrated gasification gas combined cycle plant with traditional shift reactors) characterized by the traditional water gas shift reactors and a CO 2 physical adsorption system followed by the power section. The second one is an IGCC M plant (integrated gasification gas combined cycle plant with membrane reactor) where the coal thermal input is the same as the first one, but the traditional shift reactors and the physical adsorption unit are replaced by catalytic palladium membrane reactors (CMR). In the present work, a mono-dimensional computational model of the membrane reactor was proposed to simulate and evaluate the capability of the IGCC M plant to capture carbon dioxide. The energetic performances, efficiency and net power of the IGCC* and IGCC M plants were, thus, compared, assuming as standard a traditional IGCC plant without carbon dioxide capture. The economical aspects of the three plants were compared through an economical analysis. Since the IGCC* and IGCC M plants have additional costs related to the capture and disposal of the carbon dioxide, a Carbon Tax (adopted in some countries like Sweden) proportional to the number of kilograms of carbon dioxide released in the environment was assumed. According to the economical analysis, the IGCC M plant proved to be more convenient than the IGCC* one

  15. Combined heat and power system with advanced gasification technology for biomass wastes

    Energy Technology Data Exchange (ETDEWEB)

    Mochida, S.; Abe, T.; Yasuda, T. [Nippon Furnace Kogyo Kaisha Ltd, Yokohama (Japan); Gupta, A.K. [Maryland Univ., College Park, MD (United States). Dept. of Mechnical Engineering

    2013-07-01

    The results obtained from an advanced gasification system utilizing high temperature steam are presented here. The results showed successful demonstration of clean syngas production having high calorific value fuel ({proportional_to}10 MJ/m{sup 3}N) using woody biomass wastes in a downdraft type gasifier. The gasification capacity of the plant on dry basis was 60 kg/h. The syngas produced can be utilized in an absorption type chiller for air conditioning. This advanced gasification technology allows one to transform wastes to clean energy at local production sites without any environmental impact and expensive waste transportation costs. The experience gained from the demonstration plant allows one to implement to other industrial applications for use as a decentralized unit and obtain clean syngas for local use. The demonstration conducted here shows that the system is favorable for onsite use of compatible combined heat and power (CHP) system including light oil supported diesel engine power generator. The biomass waste fuel from a lumber mill factory was used in this study. The factory handles a wide forests area of about 50 ha and produces about 2,500 m{sup 3}/year of wood chips from thin out trees and waste lumbers. This translates to a maximum 110 kg/h of wood chips that can be fed to a gasifier. The syngas produced was used for the combined heat and power system. Local use of biomass for fuel reforming reduces the cost of collection and transportation costs so that a sustainable business is demonstrated with profit from the generated electricity and thermal energy. The cost structure incorporates both the depreciation cost and operation cost of the system. Thermal energy from hot water can be used for drying lumbers and wood chips in a cascade manner. The drying process can be adopted for enhancing its productivity with increased variability on the quality of lumber. The results show that the combined heat and power system (CHP) offers good profitable

  16. Comparison of Heat Transfer Fluid and Direct Steam Generation technologies for Integrated Solar Combined Cycles

    International Nuclear Information System (INIS)

    Rovira, Antonio; Montes, María José; Varela, Fernando; Gil, Mónica

    2013-01-01

    At present time and in the medium term, Solar Thermal Power Plants are going to share scenario with conventional energy generation technologies, like fossil and nuclear. In such a context, Integrated Solar Combined Cycles (ISCCs) may be an interesting choice since integrated designs may lead to a very efficient use of the solar and fossil resources. In this work, different ISCC configurations including a solar field based on parabolic trough collectors and working with the so-called Heat Transfer Fluid (HTF) and Direct Steam Generation (DSG) technologies are compared. For each technology, four layouts have been studied: one in which solar heat is used to evaporate part of the high pressure steam of a bottoming Rankine cycle with two pressure levels, another that incorporates a preheating section to the previous layout, the third one that includes superheating instead of preheating and the last one including both preheating and superheating in addition to the evaporation. The analysis is made with the aim of finding out which of the different layouts reaches the best performance. For that purpose, three types of comparisons have been performed. The first one assesses the benefits of including a solar steam production fixed at 50 MW th . The second one compares the configurations with a standardised solar field size instead of a fixed solar steam production. Finally, the last one consists on an even more homogeneous comparison considering the same steam generator size for all the configurations as well as standardised solar fields. The configurations are studied by mean of exergy analyses. Several figures of merit are used to correctly assess the configurations. Results reveal that the only-evaporative DSG configuration becomes the best choice, since it benefits of both low irreversibility at the heat recovery steam generator and high thermal efficiency in the solar field. Highlights: ► ISCC configurations with DSG and HTF technologies are compared. ► Four

  17. Effect of Curing Conditions and Freeze-Thaw Cycles on the Strength of an Expansive Soil Stabilized with a Combination of Lime, Jaggery, and Gallnut Powder

    Directory of Open Access Journals (Sweden)

    Jijo James

    2018-01-01

    Full Text Available This investigation involved the utilization of the combination of lime, jaggery, and gallnut powder, adopted in South India traditionally. This combination of materials, used for the manufacture of lime-based mortars, was adopted in stabilization of an expansive soil. Three combinations of lime, jaggery, and gallnut powder (LJG in the ratios of 8 : 2 : 2, 8 : 2 : 1, and 8 : 1 : 2 were put into use. The effect of subjecting the combinations to alternate cycles of freeze-thaw (up to 3 cycles and three different curing conditions of air, moisture, and heat was also investigated. In addition, a mineralogical investigation for studying the reaction products was also carried out. The investigation proceeded with the determination of the unconfined compression strength (UCS of stabilized specimens of dimensions 38 mm × 76 mm, cured for periods of 3, 7, 14, and 28 days. The results of the investigation revealed that the addition of LJG resulted in an increase in the strength of the stabilized soil. Freeze-thaw cycles resulted in a reduction in strength with LJG821 proving to be the most optimal combination developing the maximum strength and least strength loss due to freeze-thaw cycles. Thermal curing proved to be the most optimal curing condition out of all curing conditions evaluated.

  18. REVIEW OF MODERN TECHNOLOGIES OF REINFORCEMENT AND STABILIZATION OF SOFT SOILS

    Directory of Open Access Journals (Sweden)

    Romanov Nikita Valer’evich

    2018-05-01

    Full Text Available Subject: description of the current situation in technologies of soil improvement, namely mechanical and hydraulic consolidation of soils and vertical reinforcement of soils for different types of soft soils. Research objectives: demonstration of modern possibilities and approaches to the design and construction of improved soils. Materials and methods: in this paper, we consider such technologies of ground improvement as dynamic compaction, hydraulic consolidation (vertical drain consolidation, Menard vacuum consolidation, vertical reinforcement of soils (CMC - controlled modulus columns. Results: the result of the study is an intuitive representation of the applicability of described technologies for various types of soft soils. Conclusions: the technologies of ground improvement considered in this article are an effective alternative to both pile foundations and soil replacement. To this day, industrial implementation of soil improvement technologies has proved its applicability, efficiency and competitiveness.

  19. Combining the technological innovation systems framework with the entrepreneurs’ perspective on innovation

    NARCIS (Netherlands)

    Planko, Julia; Cramer, Jacqueline; Hekkert, Marko P.; Chappin, Maryse M H

    2017-01-01

    For their technological sustainability innovations to become successful, entrepreneurs can strategically shape the technological field in which they are involved. The technological innovation systems (TISs) literature has generated valuable insights into the processes which need to be stimulated for

  20. Highly sensitive detection of human IgG using a novel bio-barcode assay combined with DNA chip technology

    International Nuclear Information System (INIS)

    Liu, Zhenbao; Zhou, Bo; Wang, Haiqing; Lu, Feng; Liu, Tianjun; Song, Cunxian; Leng, Xigang

    2013-01-01

    A simple and ultrasensitive detection of human IgG based on signal amplification using a novel bio-barcode assay and DNA chip technology was developed. The sensing platform was a sandwich system made up of antibody-modified magnetic microparticles (Ab-MMPs)/human IgG/Cy3-labeled single-stranded DNA and antibody-modified gold nanoparticles (Cy3-ssDNA-Ab-AuNPs). The MMPs (2.5 μm in diameter) modified with mouse anti-human IgG monoclonal-antibodies could capture human IgG and further be separated and enriched via a magnetic field. The AuNPs (13 nm in diameter) conjugated with goat anti-human IgG polyclonal-antibodies and Cy3-ssDNA could further combine with the human IgG/Ab-MMP complex. The Cy3-ssDNA on AuNPs was then released by TCEP to hybridize with the DNA chip, thus generating a detectable signal by the fluorescence intensity of Cy3. In order to improve detection sensitivity, a three-level cascaded signal amplification was developed: (1) The MMP enrichment as the first-level; (2) Large quantities of Cy3-ssDNA on AuNPs as the second-level; (3) The Cy3-ssDNA conjugate with DNA chip as the third-level. The highly sensitive technique showed an increased response of the fluorescence intensity to the increased concentration of human IgG through a detection range from 1 pg mL −1 to 10 ng mL −1 . This sensing technique could not only improve the detection sensitivity for the low concentration of human IgG but also present a robust and efficient signal amplification model. The detection method has good stability, specificity, and reproducibility and could be applied in the detection of human IgG in the real samples

  1. Highly sensitive detection of human IgG using a novel bio-barcode assay combined with DNA chip technology

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zhenbao [Central South University, School of Pharmaceutical Sciences (China); Zhou, Bo, E-mail: zhoubo1771@163.com [The Affiliated Zhongda Hospital of Southeast University, Department of Gerontology (China); Wang, Haiqing; Lu, Feng; Liu, Tianjun; Song, Cunxian; Leng, Xigang, E-mail: lengxigyky@163.com [Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College (China)

    2013-09-15

    A simple and ultrasensitive detection of human IgG based on signal amplification using a novel bio-barcode assay and DNA chip technology was developed. The sensing platform was a sandwich system made up of antibody-modified magnetic microparticles (Ab-MMPs)/human IgG/Cy3-labeled single-stranded DNA and antibody-modified gold nanoparticles (Cy3-ssDNA-Ab-AuNPs). The MMPs (2.5 {mu}m in diameter) modified with mouse anti-human IgG monoclonal-antibodies could capture human IgG and further be separated and enriched via a magnetic field. The AuNPs (13 nm in diameter) conjugated with goat anti-human IgG polyclonal-antibodies and Cy3-ssDNA could further combine with the human IgG/Ab-MMP complex. The Cy3-ssDNA on AuNPs was then released by TCEP to hybridize with the DNA chip, thus generating a detectable signal by the fluorescence intensity of Cy3. In order to improve detection sensitivity, a three-level cascaded signal amplification was developed: (1) The MMP enrichment as the first-level; (2) Large quantities of Cy3-ssDNA on AuNPs as the second-level; (3) The Cy3-ssDNA conjugate with DNA chip as the third-level. The highly sensitive technique showed an increased response of the fluorescence intensity to the increased concentration of human IgG through a detection range from 1 pg mL{sup -1} to 10 ng mL{sup -1}. This sensing technique could not only improve the detection sensitivity for the low concentration of human IgG but also present a robust and efficient signal amplification model. The detection method has good stability, specificity, and reproducibility and could be applied in the detection of human IgG in the real samples.

  2. Highly sensitive detection of human IgG using a novel bio-barcode assay combined with DNA chip technology

    Science.gov (United States)

    Liu, Zhenbao; Zhou, Bo; Wang, Haiqing; Lu, Feng; Liu, Tianjun; Song, Cunxian; Leng, Xigang

    2013-09-01

    A simple and ultrasensitive detection of human IgG based on signal amplification using a novel bio-barcode assay and DNA chip technology was developed. The sensing platform was a sandwich system made up of antibody-modified magnetic microparticles (Ab-MMPs)/human IgG/Cy3-labeled single-stranded DNA and antibody-modified gold nanoparticles (Cy3-ssDNA-Ab-AuNPs). The MMPs (2.5 μm in diameter) modified with mouse anti-human IgG monoclonal-antibodies could capture human IgG and further be separated and enriched via a magnetic field. The AuNPs (13 nm in diameter) conjugated with goat anti-human IgG polyclonal-antibodies and Cy3-ssDNA could further combine with the human IgG/Ab-MMP complex. The Cy3-ssDNA on AuNPs was then released by TCEP to hybridize with the DNA chip, thus generating a detectable signal by the fluorescence intensity of Cy3. In order to improve detection sensitivity, a three-level cascaded signal amplification was developed: (1) The MMP enrichment as the first-level; (2) Large quantities of Cy3-ssDNA on AuNPs as the second-level; (3) The Cy3-ssDNA conjugate with DNA chip as the third-level. The highly sensitive technique showed an increased response of the fluorescence intensity to the increased concentration of human IgG through a detection range from 1 pg mL-1 to 10 ng mL-1. This sensing technique could not only improve the detection sensitivity for the low concentration of human IgG but also present a robust and efficient signal amplification model. The detection method has good stability, specificity, and reproducibility and could be applied in the detection of human IgG in the real samples.

  3. Studies on the treatment efficiency of sediment phosphorus with a combined technology of PCFM and submerged macrophytes.

    Science.gov (United States)

    Zhang, Yi; He, Feng; Xia, Shibin; Zhou, Qiaohong; Wu, Zhenbin

    2015-11-01

    The removal efficiency of sediment phosphorus (P) in all fractions with a combined technology of porous ceramic filter media (PCFM) and submerged macrophytes was studied in Donghu Lake, Wuhan, China. The adsorption kinetic models of the sediment P in all fractions on PCFM could be described well by a power function equations (Qt = k · t(a), 0 macrophyte, was higher for all P forms than that of the combination of PCFM and another macrophyte, Vallisneria spiralis. This study suggested that the combination of PCFM and macrophytes could achieve a synergetic sediment P removal because the removal rates of the combinations were higher than the sum of that of PCFM and macrophytes used separately. The combined technology could be further applied to treat internal P loading in eutrophic waters. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. A Combined Remote Sensing-Numerical Modelling Approach to the Stability Analysis of Delabole Slate Quarry, Cornwall, UK

    Science.gov (United States)

    Havaej, Mohsen; Coggan, John; Stead, Doug; Elmo, Davide

    2016-04-01

    Rock slope geometry and discontinuity properties are among the most important factors in realistic rock slope analysis yet they are often oversimplified in numerical simulations. This is primarily due to the difficulties in obtaining accurate structural and geometrical data as well as the stochastic representation of discontinuities. Recent improvements in both digital data acquisition and incorporation of discrete fracture network data into numerical modelling software have provided better tools to capture rock mass characteristics, slope geometries and digital terrain models allowing more effective modelling of rock slopes. Advantages of using improved data acquisition technology include safer and faster data collection, greater areal coverage, and accurate data geo-referencing far exceed limitations due to orientation bias and occlusion. A key benefit of a detailed point cloud dataset is the ability to measure and evaluate discontinuity characteristics such as orientation, spacing/intensity and persistence. This data can be used to develop a discrete fracture network which can be imported into the numerical simulations to study the influence of the stochastic nature of the discontinuities on the failure mechanism. We demonstrate the application of digital terrestrial photogrammetry in discontinuity characterization and distinct element simulations within a slate quarry. An accurately geo-referenced photogrammetry model is used to derive the slope geometry and to characterize geological structures. We first show how a discontinuity dataset, obtained from a photogrammetry model can be used to characterize discontinuities and to develop discrete fracture networks. A deterministic three-dimensional distinct element model is then used to investigate the effect of some key input parameters (friction angle, spacing and persistence) on the stability of the quarry slope model. Finally, adopting a stochastic approach, discrete fracture networks are used as input for 3D

  5. Multifractional microablative laser combined with spacially modulated ablative (SMA) technology for facial skin rejuvenation.

    Science.gov (United States)

    Hersant, Barbara; SidAhmed-Mezi, Mounia; Chossat, Adrien; Meningaud, Jean Paul

    2017-01-01

    Due to the increasing demand for aesthetic procedures, especially facial aesthetic surgery, a new laser technology has been developed for facial skin rejuvenation and wrinkle treatment. The aim of this study was to objectively and subjectively assess the clinical efficacy and safety of Erbium:YAG laser combined with Spatially Modulated Ablation (Er:YAG + SMA) on facial skin rejuvenation. Patients with Fitzpatrick skin type's I-IV were prospectively included. Inclusion criteria consisted of having wrinkles and irregular skin texture. All patients underwent two Er:YAG + SMA sessions (1 month apart) to stimulate tissue regeneration. Er:YAG laser emits wavelength at 2,940 nm and when combined with SMA, a resonance effect is produced in the dermis to promote tissue regeneration. Facial skin elasticity and firmness were objectively assessed by Cutometer at baseline and month 6 (M6). Aesthetic improvement was qualitatively assessed using digital photographs. Patient satisfaction with regard to their facial appearance was self-assessed using the validated FACE-Q scale and the patient-perceived age VAS scale at baseline, M1, and M6. Side effects were investigated after each session. Thirty-four patients were included, 50% (18 patients) had Fitzpatrick skin type III and 41% (14 patients) were smokers. Skin elasticity indices were significantly improved: from 0.335 ± 0.015 at baseline to 0.387 ± 0.021 at M6 (P = 0.05*) for R5 (net elasticity). Skin firmness was assessed through R7 (biological elasticity) and R6 (viscoelastic ratio) at baseline and M6: a significant increase from 0.235 ± 0.01 to 0.2709 ± 0.009 (P technology offers an effective and safe treatment alternative for facial skin rejuvenation. It reduces the recovery time compared to conventional lasers such as carbon dioxide laser. Lasers Surg. Med. 49:78-83, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  6. [Effect of stability and dissolution of realgar nano-particles using solid dispersion technology].

    Science.gov (United States)

    Guo, Teng; Shi, Feng; Yang, Gang; Feng, Nian-Ping

    2013-09-01

    To improve the stability and dissolution of realgar nano-particles by solid dispersion. Using polyethylene glycol 6000 and poloxamer-188 as carriers, the solid dispersions were prepare by melting method. XRD, microscopic inspection were used to determine the status of realgar nano-particles in solid dispersions. The content and stability test of As(2)0(3) were determined by DDC-Ag method. Hydride generation atomic absorption spectrometry was used to determine the content of Arsenic and investigated the in vitro dissolution behavior of solid dispersions. The results of XRD and microscopic inspection showed that realgar nano-particles in solid dispersions were amorphous. The dissolution amount and rate of Arsenic from realgar nano-particles of all solid dispersions were increased significantly, the reunion of realgar nano-particles and content of As(2)0(3) were reduced for the formation of solid dispersions. The solid dispersion of realgar nano-particles with poloxamer-188 as carriers could obviously improve stability, dissolution and solubility.

  7. A survey of stakeholder perspectives on a proposed combined exoskeleton-wheelchair technology.

    Science.gov (United States)

    Bhatnagar, Tim; Ben Mortensen, W; Mattie, Johanne; Wolff, Jamie; Parker, Claire; Borisoff, Jaimie

    2017-07-01

    Exoskeleton technology has potential benefits for wheelchair users' health and mobility. However, there are practical barriers to their everyday use as a mobility device. In particular, challenges related to travelling longer distances and transitioning between using a wheelchair and exoskeleton walking may present significant deterrents to regular exoskeleton use. In an effort to remove these barriers, a combined exoskeleton-wheelchair concept ('COMBO') has been proposed, which aims to achieve the benefits of both these mobility technologies. Given the inherent importance of including user-stakeholder opinions when designing an assistive technology solution, a study was undertaken to explore the perspectives of wheelchair users and healthcare professionals on the proposed conceptual design of the COMBO. An online survey with quantitative and qualitative components was conducted with wheelchair users and healthcare professionals working directly with individuals with mobility impairments. Respondents rated whether they would use or recommend a COMBO for four potential reasons. Nine design features were rated and compared in terms of their importance. Content analysis was used to analyze data from an open-ended question regarding additional perceptions about using or recommending a COMBO. A total of 481 survey responses were analyzed, 354 from wheelchair users and 127 from healthcare professionals. Potential health benefits was the most highly rated reason for potential use or recommendation of a COMBO. Of the 9 design features, 2 had a median rating of very important: inclusion of a fall-protection mechanism, and the ability for the operator to use their hands while standing. Qualitative findings indicated that health and physical benefits, use for daily life activities, and psychosocial benefits were important considerations in whether to use or recommend the COMBO. This study captures the opinions and perspectives of two stakeholder groups for an exoskeleton

  8. The keyhole GTAW technology: a new welding technology joining quality and productivity; Le procede K-TIG: une nouvelle technologie de soudage combinant qualite et productivite

    Energy Technology Data Exchange (ETDEWEB)

    Le Port, P.; Laugier, M.; Scandella, F.; Lawrjaniec, D. [Institut de Soudure, 57 - Yutz (France); Boucher, Ch. [Institut de Soudure, 93 - Villepinte (France)

    2006-05-15

    This paper is a literature review regarding the keyhole GTAW technology, which has been developed and first used for industrial applications in Australia. The process enables single pass welding of a wide range of materials including stainless steels, titanium and nickel alloys, up to 12 mm thick. Process parameters (welding current, arc voltage, travel speed, the type of shielding gas and tungsten electrode dimensions) are discussed with regards to keyhole formation and stability. A comparison between standard GTAW and keyhole GTAW is provided for the welding of 12 mm thick stainless steel and titanium, showing the substantial increase in productivity that can be achieved with this new technology. Institut de Soudure has taken part in a European project aimed at assessing the possibilities of the keyhole GTAW technology. (authors)

  9. Effects of combining CBCT technology with visual root canal recurrence in treatment of elderly patients with dental pulp disease.

    Science.gov (United States)

    Cui, J-J; Peng, B; Lin, W

    2017-03-01

    The aim of this study is to analyze the effects of combining cone beam computed tomography (CBCT) technology with visual root canal recurrence in the treatment of elderly patients with dental pulp disease. 56 cases of elderly patients with dental pulp disease were contiguously selected, and randomly divided into the control group (70 teeth from 27 patients) and the observation group (77 teeth from the rest 29 patients). We adopted CBCT technology combined with conventional root canal therapy in control group and CBCT technology combined with visual root canal recurrence in observation group to compare the clinical effects. It was found that there was no statistical difference in duration of operation between the two groups (p>0.05). The operation times and the VAS during and after operation of the observation group were significantly less than that of the control group (ppulp disease.

  10. Coupling of the Functional Stability of Rat Myocardium and Activity of Lipid Peroxidation in Combined Development of Postinfarction Remodeling and Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    S. A. Afanasiev

    2016-01-01

    Full Text Available Coupling of the functional stability of rat myocardium and activity of lipid peroxidation processes in combined development of postinfarction remodeling and diabetes mellitus has been studied. The functional stability of myocardium was studied by means of the analysis of inotropic reaction on extrasystolic stimulus, the degree of left ventricular hypertrophy, and the size of scar zone. It was shown that in combined development of postinfarction cardiac remodeling of heart (PICR with diabetes mellitus (DM animal body weight decreased in less degree than in diabetic rats. Animals with combined pathology had no heart hypertrophy. The amplitude of extrasystolic contractions in rats with PICR combined with DM had no differences compared to the control group. In myocardium of rats with PICR combined with DM postextrasystolic potentiation was observed in contrast with the rats with PICR alone. The rats with combined pathology had the decreased value of TBA-active products. Thus, the results of study showed that induction of DM on the stage of the development of postinfarction remodeling increases adaptive ability of myocardium. It is manifested in inhibition of increase of LPO processes activity and maintaining of force-interval reactions of myocardium connected with calcium transport systems of sarcoplasmic reticulum of cardiomyocytes.

  11. Wabash River Coal Gasification Combined Cycle Repowering Project: Clean Coal Technology Program

    International Nuclear Information System (INIS)

    1993-05-01

    The proposed project would result in a combined-cycle power plant with lower emissions and higher efficiency than most existing coal-fired power plants of comparable size. The net plant heat rate (energy content of the fuel input per useable electrical generation output; i.e., Btu/kilowatt hour) for the new repowered unit would be a 21% improvement over the existing unit, while reducing SO 2 emissions by greater than 90% and limiting NO x emissions by greater than 85% over that produced by conventional coal-fired boilers. The technology, which relies on gasified coal, is capable of producing as much as 25% more electricity from a given amount of coal than today's conventional coal-burning methods. Besides having the positive environmental benefit of producing less pollutants per unit of power generated, the higher overall efficiency of the proposed CGCC project encourages greater utilization to meet base load requirements in order to realize the associated economic benefits. This greater utilization (i.e., increased capacity factor) of a cleaner operating plant has global environmental benefits in that it is likely that such power would replace power currently being produced by less efficient plants emitting a greater volume of pollutants per unit of power generated

  12. Feasible approach of contactless power transfer technology combined with HTS coils based on electromagnetic resonance coupling

    International Nuclear Information System (INIS)

    Chang, Yoon Do; Yim, Seong Woo; Hwang, Si Dole

    2013-01-01

    The contactless power transfer (CPT) systems have been recently gaining popularity widely since it is an available option to realize the power delivery and storage with connector-free devices across a large air gap. Especially, the CPT with electromagnetic resonance coupling method is possible to exchange energy within 2 m efficiently. However, the power transfer efficiency of CPT in commercialized products has been limited because the impedance matching of coupled coils is sensitive. As a reasonable approach, we combined the CPT system with HTS wire technology and called as, superconducting contactless power transfer (SUCPT) system. Since the superconducting coils have an enough current density, the superconducting antenna and receiver coils at CPT system have a merit to deliver and receive a mass amount of electric energy. In this paper, we present the feasibility of the SUCPT system and examine the transmission properties of SUCPT phenomenon between room temperature and very low temperature at 77 K as long as the receiver is within 1.0 m distance.

  13. An APF and MPC combined collaborative driving controller using vehicular communication technologies

    International Nuclear Information System (INIS)

    Huang, Zichao; Wu, Qing; Ma, Jie; Fan, Shiqi

    2016-01-01

    Collaborative driving is a growing domain of Intelligent Transportation Systems (ITS) which aim to navigate traffic both efficiently and safely. Cooperation between vehicles heavily rely on the comprehensive information collected. With the development of vehicular communication technologies, information can be shared between vehicles or infrastructures through Vehicle-to-Vehicle (V2V)/Vehicle-to-Infrastructure (V2I) data exchange. By taking advantage of data sharing between vehicles, this paper proposes an Artificial Potential Field (APF) and Model Predictive Control (MPC) combined controller to implement collaborative driving in complex environments. Firstly, an APF model ​containing three components is developed to describe the mutual effect and collaboration properties between vehicles and surrounding environments. Afterwards, a MPC cost function for optimized control, considering both kinematic characteristics and environmental effect conveyed by APF, is presented to address the problem of collaborative driving. Such controller is designed from the perspective of multi-objective and multi-constraint optimization which takes the vehicle motion constraints, safety and comfort requirements into consideration. The prominent advantage of the proposed approach is that it can deal with the problems of route planning and manipulating simultaneously. To validate the proposed approach, a variety of scenario simulations are conducted in MATLAB, and the performance of the proposed method are verified.

  14. Combined reservoir simulation and seismic technology, a new approach for modeling CHOPS

    Energy Technology Data Exchange (ETDEWEB)

    Aghabarati, H.; Lines, L.; Settari, A. [Calgary Univ., AB (Canada); Dumitrescu, C. [Sensor Geophysical Ltd., Calgary, AB (Canada)

    2008-10-15

    One of the primary recovery schemes for developing heavy oil reservoirs in Canada is cold heavy oil production with sand (CHOPS). With the introduction of progressive cavity pumps, CHOPS can be applied in unconsolidated or weakly consolidated formations. In order to better understand reservoir properties and recovery mechanism, this paper discussed the use of a combined reservoir simulation and seismic technology that were applied for a heavy oil reservoir situated in Saskatchewan, Canada. Using a seismic survey acquired in 1989, the study used geostatistical methods to estimate the initial reservoir porosity. Sand production was then modeled using an erosional velocity approach and the model was run based on oil production. The paper also compared the results of true porosity derived from simulation against the porosity estimated from a second seismic survey acquired in 2001. Last, the extent and the shape of the enhanced permeability region was modelled in order to estimate porosity distribution. It was concluded that the performance of the CHOPS wells depended greatly on the rate of creation of the high permeability zone around the wells. 9 refs., 2 tabs., 18 figs., 1 appendix.

  15. Cork boiling wastewater treatment and reuse through combination of advanced oxidation technologies.

    Science.gov (United States)

    Ponce-Robles, L; Miralles-Cuevas, S; Oller, I; Agüera, A; Trinidad-Lozano, M J; Yuste, F J; Malato, S

    2017-03-01

    Industrial preparation of cork consists of its immersion for approximately 1 hour in boiling water. The use of herbicides and pesticides in oak tree forests leads to absorption of these compounds by cork; thus, after boiling process, they are present in wastewater. Cork boiling wastewater shows low biodegradability and high acute toxicity involving partial inhibition of their biodegradation when conventional biological treatment is applied. In this work, a treatment line strategy based on the combination of advanced physicochemical technologies is proposed. The final objective is the reuse of wastewater in the cork boiling process; thus, reducing consumption of fresh water in the industrial process itself. Coagulation pre-treatment with 0.5 g/L of FeCl 3 attained the highest turbidity elimination (86 %) and 29 % of DOC elimination. Similar DOC removal was attained when using 1 g/L of ECOTAN BIO (selected for ozonation tests), accompanied of 64 % of turbidity removal. Ozonation treatments showed less efficiency in the complete oxidation of cork boiling wastewater, compared to solar photo-Fenton process, under the studied conditions. Nanofiltration system was successfully employed as a final purification step with the aim of obtaining a high-quality reusable permeate stream. Monitoring of unknown compounds by LC-QTOF-MS allowed the qualitative evaluation of the whole process. Acute and chronic toxicity as well as biodegradability assays were performed throughout the whole proposed treatment line.

  16. A hybrid method for information technology selection combining multi-criteria decision making (MCDM) with technology roadmapping

    OpenAIRE

    García Mejía, Jaime Andrés

    2013-01-01

    Abstract: Strategic information technology (IT) management has been recognized as vital for achieving competitive advantage. IT selection, the process of choosing the best technology alternative from a number of available options, is an important part of IT management. The IT selection is a multi-criteria decision making process, where relative importance of each criterion is determined and the degree of satisfaction of every criterion from each alternative is evaluated. Decision makers (DMs)...

  17. Plutonium stabilization and storage research in the DNFSB 94-1 core technology program

    International Nuclear Information System (INIS)

    Eller, P.G.; Avens, L.R.; Roberson, G.D.

    1998-04-01

    Recommendation 94-1 of the Defense Nuclear Facility Safety Board (DNFSB) addresses legacy actinide materials left in the US nuclear defense program pipeline when the production mission ended in 1989. The Department of Energy (DOE) Implementation Plan responding to this recommendation instituted a Core Technology program to augment the knowledge base about general chemical and physical processing and storage behavior and to assure safe interim nuclear material storage, until disposition policies are formulated. The Core Technology program focuses on plutonium, in concert with a complex-wide applied R/D program administered by Los Alamos National Laboratory. This paper will summarize the Core Technology program's first two years, describe the research program for FY98, and project the overall direction of the program in the future

  18. A MERGE model with endogenous technological change and the cost of carbon stabilization

    International Nuclear Information System (INIS)

    Kypreos, Socrates

    2007-01-01

    Two stylized backstop systems with endogenous technological learning (ETL) are introduced in the 'model for evaluating regional and global effects' (MERGE): one for the electric and the other for the non-electric markets. Then the model is applied to analyze the impacts of ETL on carbon-mitigation policy, contrasting the resulting impacts with the situation without ETL. We model research and development (R and D) spending and learning subsidies for the demonstration and deployment stage as control variables, and we investigate the ability of this extra spending to create path-dependent experience and knowledge to aid in the implementation of carbon-free technologies. Based on model estimations and sensitivity analyses, we conclude that increased commitments for the development of new technologies to advance along their learning curves has a potential for substantial reductions in the cost of mitigating climate change and thereby helping to reach safe concentrations of carbon in the atmosphere

  19. Development of the Technologies for Stabilization Treatment of the Water of the Recycling Cooling Systems at Thermal Power Plants

    Science.gov (United States)

    Vlasov, S. M.; Chichirova, N. D.; Chichirov, A. A.; Vlasova, A. Yu.; Filimonova, A. A.; Prosvirnina, D. V.

    2018-02-01

    A turbine-condensate cooling system is one of the less stable and most hard-to-control systems of maintaining optimal water chemistry. A laboratory recycling cooling water test facility, UVO-0.3, was developed for physical simulation of innovative zero-discharge water chemistry conditions and improvement of technological flowcharts of stabilization treatment of the initial and circulating water of the recycling cooling systems at thermal power plants. Experiments were conducted in the UVO-0.3 facility to investigate the processes that occur in the recycling water supply system and master new technologies of stabilization of the initial and circulating water. It is shown that, when using untreated initial water, scaling cannot be prevented even under low concentration levels. The main reason for the activation of scale depositing is the desorption of carbon dioxide that results in alkalization of the circulating water and, as a consequence, a displacement of the chemical reaction equilibrium towards the formation of slightly soluble hardness ions. Some techniques, viz., liming and alkalization of the initial water and the by-pass treatment of the circulating water, are considered. New engineering solutions have been developed for reducing the amount of scale-forming substances in the initial and circulating water. The best results were obtained by pretreating the initial water with alkalizing agents and simultaneously bypassing and treating part of the circulating water. The obtained experimental data underlie the process flowcharts of stabilization treatment of the initial and circulating TPP water that ensure scale-free and noncorrosive operation and meet the corresponding environmental requirements. Under the bypassing, the specific rates of the agents and the residual hardness are reduced compared with the conventional pretreatment.

  20. MUSIC AND AROMATHERAPY: A GOOD COMBINATION FOR REDUCING ANXIETY AND STABILIZING NON-INVASIVE HEMODYNAMIC STATUS IN PATIENTS IN THE INTENSIVE CARE UNIT

    Directory of Open Access Journals (Sweden)

    Ferry Kumala

    2018-05-01

    Full Text Available Background: Combining musical and aromatherapy therapy is expected to have a stronger effect in the reduction of anxiety and non-invasive hemodynamic stability. Objective: To examine the effect of the combination of music and aromatherapy on anxiety and non-invasive hemodynamic in patients in the intensive care unit. Methods: This was a quasy experimental study with non-equivalent group. An experimental group was given a combined musical and aromatherapy, while a control group was given music therapy. Thirty samples selected using accidental sampling, with 15 samples randomly assigned in the music group and combination group. HARS scale (Hamilton Anxiety Rating Scale was used to measure anxiety. Non-invasive hemodynamic status of patients such as blood pressure and heart rate were documented in the observation sheet. Paired t-test and one-way ANOVA were used for data analysis. Results: There were significant effects of combination therapy on anxiety (p=0.001, diastole (p=0.004 and heart rate (p=0.031, but no significant effect on systole (p=0.387. While music therapy alone had a significant effect on anxiety (p=0.001, systole (p=0.047, and diastole (p=0.037. Conclusion: The combination therapy (music-aromatherapy had a greater effect than the music therapy alone in decreasing anxiety, and stabilizing diastolic blood pressure and heart rate. This therapy can be used as an alternative in nursing interventions, and can be used as inputs to develop standard of operational procedure for anxiety and non-invasive hemodynamic stability.

  1. Selectivity and stability of new herbicides and herbicide combinations for the seed yields of some field crops I. Effect at Coriander (Coriandrum Sativum L.)

    OpenAIRE

    G. Delchev

    2016-01-01

    Abstract. . The research was conducted during 2013 – 2015 on pellic vertisol soil type. Under investigation was Bulgarian coriander cultivar Lozen 1 (Coriandrum sativum L.). The purpose of the investigation was to establish the selectivity and stability of some herbicides, herbicide combinations and herbicide tank mixtures on the coriander. Factor A included the years of investigation. Factor B included no treated check, 6 soil-applied herbicides – Tendar EC, Silba SC, Sharpen 33 EC,...

  2. Technique for Determination of Rational Boundaries in Combining Construction and Installation Processes Based on Quantitative Estimation of Technological Connections

    Science.gov (United States)

    Gusev, E. V.; Mukhametzyanov, Z. R.; Razyapov, R. V.

    2017-11-01

    The problems of the existing methods for the determination of combining and technologically interlinked construction processes and activities are considered under the modern construction conditions of various facilities. The necessity to identify common parameters that characterize the interaction nature of all the technology-related construction and installation processes and activities is shown. The research of the technologies of construction and installation processes for buildings and structures with the goal of determining a common parameter for evaluating the relationship between technologically interconnected processes and construction works are conducted. The result of this research was to identify the quantitative evaluation of interaction construction and installation processes and activities in a minimum technologically necessary volume of the previous process allowing one to plan and organize the execution of a subsequent technologically interconnected process. The quantitative evaluation is used as the basis for the calculation of the optimum range of the combination of processes and activities. The calculation method is based on the use of the graph theory. The authors applied a generic characterization parameter to reveal the technological links between construction and installation processes, and the proposed technique has adaptive properties which are key for wide use in organizational decisions forming. The article provides a written practical significance of the developed technique.

  3. Control of strength and stability of emulsion-gels by a combination of long- and short-range interactions

    NARCIS (Netherlands)

    Blijdenstein, T.B.J.; Hendriks, W.P.G.; Linden, van der E.; Vliet, van T.; Aken, van G.A.

    2003-01-01

    This paper discusses the change in phase behavior and mechanical properties of oil-in-water emulsion gels brought about by variation of long- and short-range attractive interactions. The model system studied consisted of oil droplets stabilized by the protein -lactoglobulin (-lg). A long-range

  4. Time-dependent performance of soil mix technology stabilized/solidified contaminated site soils.

    Science.gov (United States)

    Wang, Fei; Wang, Hailing; Al-Tabbaa, Abir

    2015-04-09

    This paper presents the strength and leaching performance of stabilized/solidified organic and inorganic contaminated site soil as a function of time and the effectiveness of modified clays applied in this project. Field trials of deep soil mixing application of stabilization/solidification (S/S) were performed at a site in Castleford in 2011. A number of binders and addictives were applied in this project including Portland cement (PC), ground granulated blastfurnace slag (GGBS), pulverised fuel ash (PFA), MgO and modified clays. Field trial samples were subjected to unconfined compressive strength (UCS), BS CN 12457 batch leaching test and the extraction of total organics at 28 days and 1.5 years after treatment. The results of UCS test show that the average strength values of mixes increased from 0-3250 kPa at 28 days to 250-4250 kPa at 1.5 years curing time. The BS EN 12457 leachate concentrations of all metals were well below their drinking water standard, except Ni in some mixes exceed its drinking water standard at 0.02 mg/l, suggesting that due to varied nature of binders, not all of them have the same efficiency in treating contaminated soil. The average leachate concentrations of total organics were in the range of 20-160 mg/l at 28 days after treatment and reduced to 18-140 mg/l at 1.5 years. In addition, organo clay (OC)/inorgano-organo clay (IOC) slurries used in this field trial were found to have a negative effect on the strength development, but were very effective in immobilizing heavy metals. The study also illustrates that the surfactants used to modify bentonite in this field trail were not suitable for the major organic pollutants exist in the site soil in this project. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Screening for synergistic activity of antimicrobial combinations against carbapenem-resistant Enterobacteriaceae using inkjet printer-based technology.

    Science.gov (United States)

    Brennan-Krohn, Thea; Truelson, Katherine A; Smith, Kenneth P; Kirby, James E

    2017-10-01

    Synergistic combination antimicrobial therapy may provide new options for treatment of MDR infections. However, comprehensive in vitro synergy data are limited and facile methods to perform synergy testing in a clinically actionable time frame are unavailable. To systematically investigate a broad range of antibiotic combinations for evidence of synergistic activity against a collection of carbapenem-resistant Enterobacteriaceae (CRE) isolates. We made use of an automated method for chequerboard array synergy testing based on inkjet printer technology in the HP D300 digital dispenser to test 56 pairwise antimicrobial combinations of meropenem, aztreonam, cefepime, colistin, gentamicin, levofloxacin, chloramphenicol, fosfomycin, trimethoprim/sulfamethoxazole, minocycline and rifampicin, as well as the double carbapenem combination of meropenem and ertapenem. In a screening procedure, we tested these combinations against four CRE strains and identified nine antibiotic combinations that showed potential clinically relevant synergy. In confirmatory testing using 10 CRE strains, six combinations demonstrated clinically relevant synergy with both antimicrobials at the minimum fractional inhibitory concentration (FICI-MIN) in the susceptible or intermediate range in at least one trial. These included two novel combinations: minocycline plus colistin and minocycline plus meropenem. In 80% of strains at least one combination demonstrated clinically relevant synergy, but the combinations that demonstrated synergy varied from strain to strain. This work establishes the foundation for future systematic, broad-range investigations into antibiotic synergy for CRE, emphasizes the need for individualized synergy testing and demonstrates the utility of inkjet printer-based technology for the performance of automated antimicrobial synergy assays. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights

  6. Combined osmodehydration and high pressure processing on the enzyme stability and antioxidant capacity of a grapefruit jam

    Science.gov (United States)

    A combined osmodehydration process and high pressure treatment (OD-HHP) was developed for grapefruit jam preservation. The inactivation kinetics of pectinmethylesterase (PME) and peroxidase (POD) in the osmodehydrated (OD) jam treated by combined thermal (45-75°C) and high pressure (550–700 MPa) pro...

  7. Microencapsulation of plum (Prunus salicina Lindl. phenolics by spray drying technology and storage stability

    Directory of Open Access Journals (Sweden)

    Yibin LI

    2017-10-01

    Full Text Available Abstract To improve the stability of the phenolic extracts from plum fruit (Prunus salicina Lindl., the microencapsulation conditions of spray drying were optimized by the response surface method. The Box-Behnken experimental results indicated the optimal conditions involved an inlet air temperature of 142.8 °C, a core material content of 23.7% and a feed solids content of 11.7%. The maximum microencapsulating efficiency was 87.7% at optimal conditions. Further, the physicochemical properties of the microcapsule powders were improved overall due to the addition of the coating agents. There were no statistically significant differences in phenolic content of the obtained microcapsules for the first 40 days of storage at 25 °C in dark condition (p > 0.05, and the retention rate of total phenol remained above 85% after 60 days. Microcapsules can be potentially developed as a source of natural pigment or functional food based on the advantages of rich phenolic compounds and red color.

  8. Minimally Invasive Spine Metastatic Tumor Resection and Stabilization: New Technology Yield Improved Outcome

    Directory of Open Access Journals (Sweden)

    Ran Harel

    2015-01-01

    Full Text Available Spinal metastases compressing the spinal cord are a medical emergency and should be operated on if possible; however, patients’ medical condition is often poor and surgical complications are common. Minimizing surgical extant, operative time, and blood loss can potentially reduce postoperative complications. This is a retrospective study describing the patients operated on in our department utilizing a minimally invasive surgery (MIS approach to decompress and instrument the spine from November 2013 to November 2014. Five patients were operated on for thoracic or lumbar metastases. In all cases a unilateral decompression with expandable tubular retractor was followed by instrumentation of one level above and below the index level and additional screw at the index level contralateral to the decompression side. Cannulated fenestrated screws were used (Longitude FNS and cement was injected to increase pullout resistance. Mean operative time was 134 minutes and estimated blood loss was minimal in all cases. Improvement was noticeable in neurological status, function, and pain scores. No complications were observed. Technological improvements in spinal instruments facilitate shorter and safer surgeries in oncologic patient population and thus reduce the complication rate. These technologies improve patients’ quality of life and enable the treatment of patients with comorbidities.

  9. Development of corrective measures and site stabilization technologies for shallow land burial facilities at semiarid sites

    International Nuclear Information System (INIS)

    Nyhan, J.W.; Abeele, W.V.

    1986-01-01

    The overall purpose of the corrective measures task performed for the National Low-Level Waste Management Program has been to develop and test methods that can be used to correct any actual or anticipated problems with new and existing shallow land burial (SLB) sites in a semiarid environment. These field tests have not only evaluated remedial actions, but have also investigated phenomena suspected of being a possible problem at semiarid SLB sites. The approach we have taken in developing remedial action and site closure technologies for low-level waste sites is to recognize that physical and biological processes affecting site integrity are interdependent, and therefore, cannot be treated as separate problems. The field experiments performed for this task were to identify, evaluate, and model erosion control technologies, field test second generation biointrusion barriers, determine by field experiments the extent of upward radionuclide migration due to moisture cycling, and measure the effects of subsidence on remedial action of other system components. Progress made in each of these research areas is described

  10. Digital Libraries with Embedded Values: Combining Insights from LIS and Science and Technology Studies

    Science.gov (United States)

    Fleischmann, Kenneth R.

    2007-01-01

    In the digital age, libraries are increasingly being augmented or even replaced by information technology (IT), which is often accompanied by implicit assumptions of objectivity and neutrality, yet the field of science and technology studies (STS) has a long history of studying what values are embedded in IT and how they are embedded. This article…

  11. Report on achievements in fiscal 1998. Development of useful substance production technology utilizing gene combination technology; 1998 nendo idenshi kumikae gijutsu wo riyoshita yuyo busshitsu seisan gijutsu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    In developing a useful substance producing technology utilizing gene combination technology, plants are taken as a kind of useful substance producing arena, wherein useful protein genes of animals are introduced and manifested in the plants. Thereupon, technological development was carried out for the following items with regard to mass production of useful substances that can be utilized industrially, such as cytokine, by means of plant and cell cultivation: 1. Development of a useful substance producing technology utilizing gene combination technology, and 2. Comprehensive surveys and researches. For the technology to obtain and design useful substance producing genes originated from animals, development of a technology to search and acquire useful genes originated from animals, and a design and modification technology for useful genes. For the technology to introduce genes into gene combined plants, creation of plants combined with useful substance producing genes, and development of an introduction technology using plant virus vector. For the technology to produce high-function chemical substances in the gene combined plants, establishment of technologies for mass breeding and activity analysis of gene combined plants and cultivated cells, and for extraction and refinement of useful substances from the gene combined plants. In the comprehensive surveys and researches, technologies were surveyed and items of information were collected inside and outside the country. (NEDO)

  12. Calcium looping technology using improved stability nanostructured sorbent for cyclic CO{sub 2} capture

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Cong; Zheng, Ying; Ding, Ning; Zheng, Chu-guang [Huazhong Univ. of Science and Technology, Wuhan (China). State Key Lab. of Coal Combustion

    2013-07-01

    One of the post-combustion CO{sub 2} capture technologies that have sufficiently been proved to be the best candidates for practical large scale post-combustion application is the calcium looping cycle. However, the CO{sub 2} capture capacity of a calcium-based sorbent derived from natural limestone decays through long-term cyclic utilization; thus, the development of novel sorbents to achieve a high CO{sub 2} capture capacity is an critical challenge for the calcium looping cycle technology. In this paper, we report the preparation and character of a new calcium-based sorbent produced via the combustion of a dry gel. The results show that the novel calcium-based sorbent has a much higher residual carbonation conversion as well as a better performance of anti-sintering when compared with the calcium-based sorbent derived from commercial micrometer grade CaCO{sub 3} and nanometer grade CaCO{sub 3}. It is reasonable to propose that the different final carbonation performances are induced by their different pore structures and BET surface areas rather than by different particle sizes. Compared with the commercial nano CaO, the morphology of the new sorbent shows a more rough porous appearance with hollow nanostructure. During carbonation, CO{sub 2} diffused more easily through the hollow structure than through a solid structure to reach the unreacted CaO. Besides, there is less chance for the hollow nanostructured particles to be merged together during the high temperature reactions.

  13. Novel in silico technology in combination with microarrays: a state-of-the-art technology for allergy diagnosis and management?

    Science.gov (United States)

    Melioli, Giovanni; Passalacqua, Giovanni; Canonica, Giorgio W

    2014-12-01

    'Allergen microarrays, in poly-sensitized allergic patients, represent a real value added in the accurate IgE profiling and in the identification of allergen(s) to administer for an effective allergen immunotherapy.' Allergen microarrays (AMA) were developed in the early 2000s to improve the diagnostic pathway of patients with allergic reactions. Nowadays, AMA are constituted by more than 100 different components (either purified or recombinant), representing genuine and cross-reacting molecules from plants and animals. The cost of the procedure had suggested its use as third-level diagnostics (following in vivo- and in vitro-specific IgE tests) in poly-sensitized patients. The complexity of the interpretation had inspired the development of in silico technologies to help clinicians in their work. Both machine learning techniques and expert systems are now available. In particular, an expert system that has been recently developed not only identifies positive and negative components but also lists dangerous components and classifies patients based on their potential responsiveness to allergen immunotherapy, on the basis of published algorithms. For these characteristics, AMA represents the state-of-the-art technology for allergy diagnosis in poly-sensitized patients.

  14. Combined Heat and Power Systems Technology Development and Demonstration 370 kW High Efficiency Microturbine

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2015-10-14

    The C370 Program was awarded in October 2010 with the ambitious goal of designing and testing the most electrically efficient recuperated microturbine engine at a rated power of less than 500 kW. The aggressive targets for electrical efficiency, emission regulatory compliance, and the estimated price point make the system state-of-the-art for microturbine engine systems. These goals will be met by designing a two stage microturbine engine identified as the low pressure spool and high pressure spool that are based on derivative hardware of Capstone’s current commercially available engines. The development and testing of the engine occurred in two phases. Phase I focused on developing a higher power and more efficient engine, that would become the low pressure spool which is based on Capstone’s C200 (200kW) engine architecture. Phase II integrated the low pressure spool created in Phase I with the high pressure spool, which is based on Capstone’s C65 (65 kW) commercially available engine. Integration of the engines, based on preliminary research, would allow the dual spool engine to provide electrical power in excess of 370 kW, with electrical efficiency approaching 42%. If both of these targets were met coupled with the overall CHP target of 85% total combined heating and electrical efficiency California Air Resources Board (CARB) level emissions, and a price target of $600 per kW, the system would represent a step change in the currently available commercial generation technology. Phase I of the C370 program required the development of the C370 low pressure spool. The goal was to increase the C200 engine power by a minimum of 25% — 250 kW — and efficiency from 32% to 37%. These increases in the C200 engine output were imperative to meet the power requirements of the engine when both spools were integrated. An additional benefit of designing and testing the C370 low pressure spool was the possibility of developing a stand-alone product for possible

  15. Application of RFID combined with blockchain technology in logistics of construction materials

    Directory of Open Access Journals (Sweden)

    Lanko A.

    2018-01-01

    Full Text Available Nowadays, almost none of the fields of human activity can do without supply chain management. In addition, implementation of one in construction companies contributes to major economic benefits. The article considers the application feasibility of blockchain in logistics of construction materials through the usage of RFID technology. An example of introduction to the process of manufacturing and delivery of ready-mixed concrete is given. The main advantages, shortcomings, perspectives, as well as difficulties arising in the implementation of blockchain technology in the construction industry are described. Special attention is paid to the applicability of these technologies.

  16. In-Vitro Inhibition of Pythium ultimum, Fusarium graminearum, and Rhizoctonia solani by a Stabilized Lactoperoxidase System alone and in Combination with Synthetic Fungicides

    Directory of Open Access Journals (Sweden)

    Zachariah R. Hansen

    2017-11-01

    Full Text Available Advances in enzyme stabilization and immobilization make the use of enzymes for industrial applications increasingly feasible. The lactoperoxidase (LPO system is a naturally occurring enzyme system with known antimicrobial activity. Stabilized LPO and glucose oxidase (GOx enzymes were combined with glucose, potassium iodide, and ammonium thiocyanate to create an anti-fungal formulation, which inhibited in-vitro growth of the plant pathogenic oomycete Pythium ultimum, and the plant pathogenic fungi Fusarium graminearum and Rhizoctonia solani. Pythium ultimum was more sensitive than F. graminearum and R. solani, and was killed at LPO and GOx concentrations of 20 nM and 26 nM, respectively. Rhizoctonia solani and F. graminearum were 70% to 80% inhibited by LPO and GOx concentrations of 242 nM and 315 nM, respectively. The enzyme system was tested for compatibility with five commercial fungicides as co-treatments. The majority of enzyme + fungicide co-treatments resulted in additive activity. Synergism ranging from 7% to 36% above the expected additive activity was observed when P. ultimum was exposed to the enzyme system combined with Daconil® (active ingredient (AI: chlorothalonil 29.6%, GardenTech, Lexington, KY, USA, tea tree oil, and mancozeb at select fungicide concentrations. Antagonism was observed when the enzyme system was combined with Tilt® (AI: propiconazole 41.8%, Syngenta, Basel, Switzerland at one fungicide concentration, resulting in activity 24% below the expected additive activity at that concentration.

  17. Preparation and characterization of quercetin-loaded silica microspheres stabilized by combined multiple emulsion and sol-gel processes

    Directory of Open Access Journals (Sweden)

    Kim Young Ho

    2015-01-01

    Full Text Available Despite exhibiting a wide spectrum of cosmeceutical properties, flavonoids and related compounds have some limitations related to their stability and solubility in distilledwater. In this project, we prepared silica microspheres using a novel method that uses polyol-in-oil-in-water (P/O/W emulsion and sol-gel methods as techniques for stabilizing quercetin. A stable microsphere suspension was successfully preparedusing a mixed solvent system comprising a polyol-phase medium for performing the sol-gel processing of tetraethyl orthosilicate (TEOS as an inorganic precursor with outer water phase. The morphology of the microsphere was evaluated using a scanning electron microscope (SEM, which showed a characteristic spherical particle shape with a smooth surface. Furthermore, SEM/EDSanalysis of a representative microsphere demonstrated that the inner structure of the silica microspheres was filled with quercetin. The mean diameter of the microsphere was in the range 20.6-35.0 μm, and the encapsulation efficiency ranged from 17.8% to 27.5%. The free and encapsulated quercetin samples were incubated in separateaqueous solutions at 25 and 42°C for 28 days. The residualcontent of the quercetin encapsulated by silica microspheres was 82% at 42°C. In contrast, that of the free quercetin stored at 42°C decreased to ~24%.

  18. DJINNI: A Novel Technology Supported Exposure Therapy Paradigm for SAD Combining Virtual Reality and Augmented Reality

    Science.gov (United States)

    Ben-Moussa, Maher; Rubo, Marius; Debracque, Coralie; Lange, Wolf-Gero

    2017-01-01

    The present paper explores the benefits and the capabilities of various emerging state-of-the-art interactive 3D and Internet of Things technologies and investigates how these technologies can be exploited to develop a more effective technology supported exposure therapy solution for social anxiety disorder. “DJINNI” is a conceptual design of an in vivo augmented reality (AR) exposure therapy mobile support system that exploits several capturing technologies and integrates the patient’s state and situation by vision-based, audio-based, and physiology-based analysis as well as by indoor/outdoor localization techniques. DJINNI also comprises an innovative virtual reality exposure therapy system that is adaptive and customizable to the demands of the in vivo experience and therapeutic progress. DJINNI follows a gamification approach where rewards and achievements are utilized to motivate the patient to progress in her/his treatment. The current paper reviews the state of the art of technologies needed for such a solution and recommends how these technologies could be integrated in the development of an individually tailored and yet feasible and effective AR/virtual reality-based exposure therapy. Finally, the paper outlines how DJINNI could be part of classical cognitive behavioral treatment and how to validate such a setup. PMID:28503155

  19. DJINNI: A Novel Technology Supported Exposure Therapy Paradigm for SAD Combining Virtual Reality and Augmented Reality.

    Science.gov (United States)

    Ben-Moussa, Maher; Rubo, Marius; Debracque, Coralie; Lange, Wolf-Gero

    2017-01-01

    The present paper explores the benefits and the capabilities of various emerging state-of-the-art interactive 3D and Internet of Things technologies and investigates how these technologies can be exploited to develop a more effective technology supported exposure therapy solution for social anxiety disorder. "DJINNI" is a conceptual design of an in vivo augmented reality (AR) exposure therapy mobile support system that exploits several capturing technologies and integrates the patient's state and situation by vision-based, audio-based, and physiology-based analysis as well as by indoor/outdoor localization techniques. DJINNI also comprises an innovative virtual reality exposure therapy system that is adaptive and customizable to the demands of the in vivo experience and therapeutic progress. DJINNI follows a gamification approach where rewards and achievements are utilized to motivate the patient to progress in her/his treatment. The current paper reviews the state of the art of technologies needed for such a solution and recommends how these technologies could be integrated in the development of an individually tailored and yet feasible and effective AR/virtual reality-based exposure therapy. Finally, the paper outlines how DJINNI could be part of classical cognitive behavioral treatment and how to validate such a setup.

  20. DJINNI: A Novel Technology Supported Exposure Therapy Paradigm for SAD Combining Virtual Reality and Augmented Reality

    Directory of Open Access Journals (Sweden)

    Maher Ben-Moussa

    2017-04-01

    Full Text Available The present paper explores the benefits and the capabilities of various emerging state-of-the-art interactive 3D and Internet of Things technologies and investigates how these technologies can be exploited to develop a more effective technology supported exposure therapy solution for social anxiety disorder. “DJINNI” is a conceptual design of an in vivo augmented reality (AR exposure therapy mobile support system that exploits several capturing technologies and integrates the patient’s state and situation by vision-based, audio-based, and physiology-based analysis as well as by indoor/outdoor localization techniques. DJINNI also comprises an innovative virtual reality exposure therapy system that is adaptive and customizable to the demands of the in vivo experience and therapeutic progress. DJINNI follows a gamification approach where rewards and achievements are utilized to motivate the patient to progress in her/his treatment. The current paper reviews the state of the art of technologies needed for such a solution and recommends how these technologies could be integrated in the development of an individually tailored and yet feasible and effective AR/virtual reality-based exposure therapy. Finally, the paper outlines how DJINNI could be part of classical cognitive behavioral treatment and how to validate such a setup.

  1. Dense and high-stability Ti2AlN MAX phase coatings prepared by the combined cathodic arc/sputter technique

    Science.gov (United States)

    Wang, Zhenyu; Liu, Jingzhou; Wang, Li; Li, Xiaowei; Ke, Peiling; Wang, Aiying

    2017-02-01

    Ti2AlN belongs to a family of ternary nano-laminate alloys known as the MAX phases, which exhibit a unique combination of metallic and ceramic properties. In the present work, the dense and high-stability Ti2AlN coating has been successfully prepared through the combined cathodic arc/sputter deposition, followed by heat post-treatment. It was found that the as-deposited Ti-Al-N coating behaved a multilayer structure, where (Ti, N)-rich layer and Al-rich layer grew alternately, with a mixed phase constitution of TiN and TiAlx. After annealing at 800 °C under vacuum condition for 1.5 h, although the multilayer structure still was found, part of multilayer interfaces became indistinct and disappeared. In particular, the thickness of the Al-rich layer decreased in contrast to that of as-deposited coating due to the inner diffusion of the Al element. Moreover, the Ti2AlN MAX phase emerged as the major phase in the annealed coatings and its formation mechanism was also discussed in this study. The vacuum thermal analysis indicated that the formed Ti2AlN MAX phase exhibited a high-stability, which was mainly benefited from the large thickness and the dense structure. This advanced technique based on the combined cathodic arc/sputter method could be extended to deposit other MAX phase coatings with tailored high performance like good thermal stability, high corrosion and oxidation resistance etc. for the next protective coating materials.

  2. Effect of nitrite on the microbiological stability of canned Vienna sausages preserved by mild heat treatment or combinations of heat and irradiation

    International Nuclear Information System (INIS)

    Farkas, J.; Zukal, E.; Incze, K.

    1973-01-01

    Keeping quality of Vienna sausages packed in No. 1/5 cans (ca 200 g) with salt brine and heat treated with F 0 values in the range of 0.25-0.55 was studied as a function of sodium nitrate addition. In uninoculated cans the heat requirement of preservation proved to be about 0.3 F 0 in the presence of 300 ppm NaNO 2 . A heat treatment of 0.55 F 0 and 200 ppm NaNO 2 resulted in higher microbiological stability of cans inoculated with 2x10 4 /tin Clostridium sporogenes spores than a heat treatment of 1.9 F 0 without nitrite addition. The effect of the combination of heat treatment of 0.35-0.55 F 0 and 0.45 Mrad of gamma irradiation was also studied with inoculated cans. The combination of irradiation plus heat resulted in a higher microbiological stability of the samples than the reversed order of the treatments, but this synergistic effect could not be proved in all experiments. The addition of 200 ppm NaNO 2 was not as effective in increasing the shelf-life of combination treated samples as with the solely heat treated ones. In a medium composed of a 50% extract of Vienna sausages (pH 6.4, asub(w) 0.96) and inoculated with 10 5 per ml Clostridium sporogenes spores 100 ppm or more NaNO 2 was required to ensure microbiological stability of samples heat treated with F 0 0.4. In the range of the permitted concentration level for canned meat products, sodium nitrite did not influence the heat resistance of Clostridium sporogenes, but inhibited the germination of the surviving spores. (F.J.)

  3. Multiobjective Optimization Combining BMP Technology and Land Preservation for Watershed-based Stormwater Management

    Science.gov (United States)

    McGarity, A. E.

    2009-12-01

    Recent progress has been made developing decision-support models for optimal deployment of best management practices (BMP’s) in an urban watershed to achieve water quality goals. One example is the high-level screening model StormWISE, developed by the author (McGarity, 2006) that uses linear and nonlinear programming to narrow the search for optimal solutions to certain land use categories and drainage zones. Another example is the model SUSTAIN developed by USEPA and Tetra Tech (Lai, et al., 2006), which builds on the work of Yu, et al., 2002), that uses a detailed, computationally intensive simulation model driven by a genetic solver to select optimal BMP sites. However, a model that deals only with best management practice (BMP) site selections may fail to consider solutions that avoid future nonpoint pollutant loadings by preserving undeveloped land. This paper presents results of a recently completed research project in which water resource engineers partnered with experienced professionals at a land conservation trust to develop a multiobjective model for watershed management. The result is a revised version of StormWISE that can be used to identify optimal, cost-effective combinations of easements and similar land preservation tools for undeveloped sites along with low impact development (LID) and BMP technologies for developed sites. The goal is to achieve the watershed-wide limits on runoff volume and pollutant loads that are necessary to meet water quality goals as well as ecological benefits associated with habitat preservation and enhancement. A nonlinear programming formulation is presented for the extended StormWISE model that achieves desired levels of environmental benefits at minimum cost. Tradeoffs between different environmental benefits are generated by multiple runs of the model while varying the levels of each environmental benefit obtained. The model is solved using piecewise linearization of environmental benefit functions where each

  4. Physicochemical Stability of an Oral Suspension of Trimethoprim 20 mg/mL in Combination with Sulfadiazine 200 mg/mL in PCCA Base SuspendIt.

    Science.gov (United States)

    Graves, Richard A; Phan, Kelly V; Bostanian, Levon A; Mandal, Tarun K; Pramar, Yashoda V

    2017-01-01

    Trimethoprim is a diaminopyrimidine antibacterial agent that, like sulfonamides, inhibits bacterial folic acid synthesis, but at a different stage in the metabolic pathway. It has a similar spectrum of activity to the sulfonamides and is given by mouth or by injection, either alone or in conjunction with a sulfonamide, such as sulfadiazine. Sulfadiazine is a bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. The combination of the two drugs produces a synergistic effect against both Gram-positive and Gram-negative aerobic bacteria, by inhibiting enzymes in the folic acid pathways, which in turn inhibits bacterial thymidine synthesis. There are no published studies of the stability of the combination of trimethoprim and sulfadiazine in a liquid dosage form. An extemporaneously compounded suspension from pure drug powders or commercial tablets would provide an alternative option to meet unique patient needs. The purpose of this study was to determine the physicochemical stability of trimethoprim combined with sulfadiazine in PCCA base SuspendIt. PCCA base SuspendIt is a sugar-free, paraben-free, dye-free, and gluten-free thixotropic vehicle containing a natural sweetener obtained from the monk fruit. It thickens upon standing to minimize settling of any insoluble drug particles and becomes fluid upon shaking to allow convenient pouring during administration to the patient. A robust stability-indicating high-performance liquid chromatographic assay for the simultaneous determination of trimethoprim and sulfadiazine in SuspendIt was developed and validated. This assay was used to determine the chemical stability of both drugs in SuspendIt. Samples were prepared and stored under three different temperature conditions (5°C, 25°C, 40°C), and assayed using the high-performance liquid chromatographic assay at pre-determined intervals over an extended period of time as follows: 0, 7, 14, 30, 45, 60, 91, 120, and 182 days

  5. Comparison of Technological Options for Distributed Generation-Combined Heat and Power in Rajasthan State of India

    Directory of Open Access Journals (Sweden)

    Ram Kumar Agrawal

    2013-01-01

    Full Text Available Distributed generation (DG of electricity is expected to become more important in the future electricity generation system. This paper reviews the different technological options available for DG. DG offers a number of potential benefits. The ability to use the waste heat from fuel-operated DG, known as combined heat and power (CHP, offers both reduced costs and significant reductions of CO2 emissions. The overall efficiency of DG-CHP system can approach 90 percent, a significant improvement over the 30 to 35 percent electric grid efficiency and 50 to 90 percent industrial boiler efficiency when separate production is used. The costs of generation of electricity from six key DG-CHP technologies; gas engines, diesel engines, biodiesel CI engines, microturbines, gas turbines, and fuel cells, are calculated. The cost of generation is dependent on the load factor and the discount rate. It is found that annualized life cycle cost (ALCC of the DG-CHP technologies is approximately half that of the DG technologies without CHP. Considering the ALCC of different DG-CHP technologies, the gas I.C. engine CHP is the most effective for most of the cases but biodiesel CI engine CHP seems to be a promising DG-CHP technology in near future for Rajasthan state due to renewable nature of the fuel.

  6. Combined treatment technology based on synergism between hydrodynamic cavitation and advanced oxidation processes.

    Science.gov (United States)

    Gogate, Parag R; Patil, Pankaj N

    2015-07-01

    The present work highlights the novel approach of combination of hydrodynamic cavitation and advanced oxidation processes for wastewater treatment. The initial part of the work concentrates on the critical analysis of the literature related to the combined approaches based on hydrodynamic cavitation followed by a case study of triazophos degradation using different approaches. The analysis of different combinations based on hydrodynamic cavitation with the Fenton chemistry, advanced Fenton chemistry, ozonation, photocatalytic oxidation, and use of hydrogen peroxide has been highlighted with recommendations for important design parameters. Subsequently degradation of triazophos pesticide in aqueous solution (20 ppm solution of commercially available triazophos pesticide) has been investigated using hydrodynamic cavitation and ozonation operated individually and in combination for the first time. Effect of different operating parameters like inlet pressure (1-8 bar) and initial pH (2.5-8) have been investigated initially. The effect of addition of Fenton's reagent at different loadings on the extent of degradation has also been investigated. The combined method of hydrodynamic cavitation and ozone has been studied using two approaches of injecting ozone in the solution tank and at the orifice (at the flow rate of 0.576 g/h and 1.95 g/h). About 50% degradation of triazophos was achieved by hydrodynamic cavitation alone under optimized operating parameters. About 80% degradation of triazophos was achieved by combination of hydrodynamic cavitation and Fenton's reagent whereas complete degradation was achieved using combination of hydrodynamic cavitation and ozonation. TOC removal of 96% was also obtained for the combination of ozone and hydrodynamic cavitation making it the best treatment strategy for removal of triazophos. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Economic assessment of combined cycle gas turbines in Australia Some effects of microeconomic reform and technological change

    International Nuclear Information System (INIS)

    Naughten, Barry

    2003-01-01

    Australian electricity markets and natural gas markets are undergoing rapid reform. Choosing among electricity generation modes is a key issue. Such choices are affected by expectations about the future structure of these markets and future technologies, and how they affect costs and emissions. In the research reported in this paper, the MARKAL model of the Australian energy system is used to evaluate the competitive position of natural gas fired combined cycle gas turbines (CCGTs) in the energy sector as a whole. Competing in the sector are large-scale electricity generation technologies such as refurbished existing coal fired stations and advanced forms of coal fired generation. The modelling incorporates new data on electricity supply technologies and options

  8. Technologies for small scale wood-fueled combined heat and power systems

    Energy Technology Data Exchange (ETDEWEB)

    Houmann Jakobsen, H.; Houmoeller, S.; Thaaning Pedersen, L.

    1998-01-01

    The aim of this study is to describe and compare different technologies for small cogeneration systems (up to 2-3 MW{sub e}), based on wood as fuel. For decentralized cogeneration, i.e. for recovering energy from saw mill wood wastes or heat supply for small villages, it is vital to know the advantages and disadvantages of the different technologies. Also, for the decision-makers it is of importance to know the price levels of the different technologies. A typical obstacle for small wood cogeneration systems is the installation costs. The specific price (per kW) is usually higher than for larger plants or plants using fossil fuels. For a saw mill choosing between cogeneration and simple heat production, however, the larger installation costs are counter weighed by the sale of electricity, while the fuel consumption is the same. Whether it is profitable or not to invest in cogeneration is often hard to decide. For many years small wood cogeneration systems have been too expensive, leading to the construction of only heat producing systems due to too high price levels of small steam turbines. In recent years a great deal of effort has been put into research and developing of new technologies to replace this traditional steam turbine. Among these are: Steam engines; Stirling engines; Indirectly fired gas turbines; Pressurized down draft combustion. Along with the small scale traditional steam turbines, these technologies will be evaluated in this study. When some or all these technologies are fully developed and commercial, a strong means of reducing the strain on the environment and the greenhouse effect will be available, as the total efficiency is high (up to 90%) and wood is an energy source in balance with nature. (au) EFP-95. 19 refs.

  9. Colloidal properties of sodium caseinate-stabilized nanoemulsions prepared by a combination of a high-energy homogenization and evaporative ripening methods.

    Science.gov (United States)

    Montes de Oca-Ávalos, J M; Candal, R J; Herrera, M L

    2017-10-01

    Nanoemulsions stabilized by sodium caseinate (NaCas) were prepared using a combination of a high-energy homogenization and evaporative ripening methods. The effects of protein concentration and sucrose addition on physical properties were analyzed by dynamic light scattering (DLS), Turbiscan analysis, confocal laser scanning microscopy (CLSM) and small angle X-ray scattering (SAXS). Droplets sizes were smaller (~100nm in diameter) than the ones obtained by other methods (200 to 2000nm in diameter). The stability behavior was also different. These emulsions were not destabilized by creaming. As droplets were so small, gravitational forces were negligible. On the contrary, when they showed destabilization the main mechanism was flocculation. Stability of nanoemulsions increased with increasing protein concentrations. Nanoemulsions with 3 or 4wt% NaCas were slightly turbid systems that remained stable for at least two months. According to SAXS and Turbiscan results, aggregates remained in the nano range showing small tendency to aggregation. In those systems, interactive forces were weak due to the small diameter of flocs. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Investigation by response surface methodology of the combined effect of pH and composition of water-methanol mixtures on the stability of curcuminoids.

    Science.gov (United States)

    D'Archivio, Angelo Antonio; Maggi, Maria Anna

    2017-03-15

    Response surface methodology, coupled to a full factorial three-level experimental design, was applied to investigate the combined influence of pH (between 7.0 and 8.6) and composition of methanol-water mixtures (between 30 and 70% v/v of methanol content) on the stability of curcumin and its analogues demethoxycurcumin and bisdemethoxycurcumin. The response plots revealed that addition of methanol noticeably improved the stability of curcuminoids, this effect being both pH- and structure-dependent. In the central point of the experimental domain, half-life times of curcumin, demethoxycurcumin and bisdemethoxycurcumin were 3.8±0.2, 27±2 and 251±17h, respectively. Stability of curcuminoids increased at lower pH and higher methanol content and decreased in the opposite vertex of the experimental domain. These results can be interpreted by assuming that addition of methanol to water produces a different variation of pH of the medium and apparent pKa values of the ionisable groups of curcuminoids. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Combined analysis of climate, technological and price changes on future arable farming systems in Europe

    NARCIS (Netherlands)

    Wolf, J.; Kanellopoulos, Argyris; Kros, J.; Webber, H.; Zhao, G.; Britz, W.; Reinds, G.J.; Ewert, F.; Vries, de W.

    2015-01-01

    In this study, we compare the relative importance of climate change to technological, management, price and policy changes on European arable farming systems. This required linking four models: the SIMPLACE crop growth modelling framework to calculate future yields under climate change for arable

  12. Combining new data gathering technology to investigate pedestrian movements in cities

    NARCIS (Netherlands)

    Palm, H.; Wismans, Luc Johannes Josephus; de Kievit, E.

    2015-01-01

    Little is known about pedestrian movements, densities and presence in city centers, although this knowledge could improve city planning, design of infrastructure and management of traffic flows. New data sources available due to fast developments in information and communication technology offer new

  13. The Learning Environment Associated with Information Technology Education in Taiwan: Combining Psychosocial and Physical Aspects

    Science.gov (United States)

    Liu, Chia-Ju; Zandvliet, David B.; Hou, I.-Ling

    2012-01-01

    This study investigated perceptions of senior high school students towards the Taiwanese information technology (IT) classroom with the What Is Happening in this Class? (WIHIC) survey and explored the physical learning environment of the IT classroom using the Computerised Classroom Environment Inventory (CCEI). The participants included 2,869…

  14. Becoming allies: Combining social science and technological perspectives to improve energy research and policy making

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, Rick; Moezzi, Mithra

    2002-07-01

    Within the energy research community, social sciences tends to be viewed fairly narrowly, often as simply a marketing tool to change the behavior of consumers and decision makers, and to ''attack market barriers''. As we see it, social sciences, which draws on sociology, psychology, political science, business administration, and other academic disciplines, is capable of far more. A social science perspective can re-align questions in ways that can lead to the development of technologies and technology policy that are much stronger and potentially more successful than they would be otherwise. In most energy policies governing commercial buildings, the prevailing R and D directives are firmly rooted in a technology framework, one that is generally more quantitative and evaluative than that fostered by the social sciences. To illustrate how social science thinking would approach the goal of achieving high energy performance in the commercial building sector, they focus on the US Department of Energy's Roadmap for commercial buildings (DOE 2000) as a starting point. By ''deconstructing'' the four strategies provided by the Roadmap, they set the stage for proposing a closer partnership between advocates of technology-based and social science-based approaches.

  15. Combining new data gathering technology and city analytics to investigate pedestrian movements

    NARCIS (Netherlands)

    Palm, H.; Wismans, Luc Johannes Josephus; de Kievit, E.

    2015-01-01

    Little is known about pedestrian movements, densities and presence in city centers, although this knowledge could improve city planning, design of infrastructure and management of traffic flows. New data sources available due to fast developments in information and communication technology offer new

  16. Body-force-driven multiplicity and stability of combined free and forced convection in rotating curved ducts: Coriolis force

    Science.gov (United States)

    Yang, T.; Wang, L.

    A numerical study is made on the fully developed bifurcation structure and stability of forced convection in a rotating curved duct of square cross-section. Solution structure is determined as variation of a parameter that indicates the effect of rotation (Coriolis-force-driven multiplicity). Three solutions for the flows in a stationary curved duct obtained in the work of Yang and Wang [1] are used as initial solutions of continuation calculations to unfold the solution branches. Twenty-one solution branches are found comparing with five obtained by Selmi and Nandakumar [2]. Dynamic responses of the multiple solutions to finite random disturbances are examined by the direct transient computation. Results show that characteristics of physically realizable fully developed flows changes significantly with variation of effect of rotation. Fourteen sub-ranges are identified according to characteristics of physically realizable solutions. As rotation effect changes, possible physically realizable fully-developed flows can be stable steady 2-cell state, stable multi-cell state, temporal periodic oscillation between symmetric/asymmetric 2-cell/4-cell flows, temporal oscillation with intermittency, temporal chaotic oscillation and temporal oscillation with pseudo intermittency. Among these possible physically realizable fully developed flows, stable multi-cell state and stable steady 2-cell state exist as dual stable. And oscillation with pseudo intermittency is a new phenomenon. In addition to the temporal oscillation with intermittency, sudden shift from stationary stable solution to temporal chaotic oscillation is identified to be another way of onset of chaos.

  17. [Research on the application of in-situ biological stabilization solidification technology in chromium contaminated site management].

    Science.gov (United States)

    Zhang, Jian-rong; Li, Juan; Xu, Wei

    2013-09-01

    In-situ biological stabilization solidification (SS) technology is an effective ground water risk control method for chromium contaminated sites. Through on-site engineering test, this paper has preliminarily validated the remediation effect of in-situ SS method on a southern chromium contaminated site. The engineering test site has an area of approximately 600 m2, and is located at the upstream of the contaminated area. Due to the severe contamination of chromium, the total chromium concentration reached up to 11,850 mg x kg(-1), while the hexavalent chromium concentration reached up to 349 mg x kg(-1), and the most severely contaminated soil had a depth of -0.5 - -2 m. Variations in hexavalent chromium and total chromium concentration in groundwater were observed through the injection of reducing agents and microbial regulators into the injection wells in the test site, and through the monitoring analysis at different time and different depth under the action of the injection agents. Results of the engineering test showed that the on-site SS technology significantly changed the chromium speciation in soil and then reduced the migration of chromium, thus the groundwater risk was reduced. The injected agents had a good effect of hexavalent chromium remediation in groundwater within the effective range of the injection wells, and the SS rate of hexavalent chromium into trivalent chromium reached 94%-99.9%, the SS rate of total chromium fixation reached 83.9%-99.8%. The test results are of significant reference value for the remediation of contaminated sites with features of shallow groundwater depth and soil mainly consisting of silty clay and sandy clay.

  18. Rice Husk Ash to Stabilize Heavy Metals Contained in Municipal Solid Waste Incineration Fly Ash: First Results by Applying New Pre-treatment Technology

    Directory of Open Access Journals (Sweden)

    Laura Benassi

    2015-10-01

    Full Text Available A new technology was recently developed for municipal solid waste incineration (MSWI fly ash stabilization, based on the employment of all waste and byproduct materials. In particular, the proposed method is based on the use of amorphous silica contained in rice husk ash (RHA, an agricultural byproduct material (COSMOS-RICE project. The obtained final inert can be applied in several applications to produce “green composites”. In this work, for the first time, a process for pre-treatment of rice husk, before its use in the stabilization of heavy metals, based on the employment of Instant Pressure Drop technology (DIC was tested. The aim of this work is to verify the influence of the pre-treatment on the efficiency on heavy metals stabilization in the COSMOS-RICE technology. DIC technique is based on a thermomechanical effect induced by an abrupt transition from high steam pressure to a vacuum, to produce changes in the material. Two different DIC pre-treatments were selected and thermal annealing at different temperatures were performed on rice husk. The resulting RHAs were employed to obtain COSMOS-RICE samples, and the stabilization procedure was tested on the MSWI fly ash. In the frame of this work, some thermal treatments were also realized in O2-limiting conditions, to test the effect of charcoal obtained from RHA on the stabilization procedure. The results of this work show that the application of DIC technology into existing treatment cycles of some waste materials should be investigated in more details to offer the possibility to stabilize and reuse waste.

  19. Rice Husk Ash to Stabilize Heavy Metals Contained in Municipal Solid Waste Incineration Fly Ash: First Results by Applying New Pre-treatment Technology

    Science.gov (United States)

    Benassi, Laura; Franchi, Federica; Catina, Daniele; Cioffi, Flavio; Rodella, Nicola; Borgese, Laura; Pasquali, Michela; Depero, Laura E.; Bontempi, Elza

    2015-01-01

    A new technology was recently developed for municipal solid waste incineration (MSWI) fly ash stabilization, based on the employment of all waste and byproduct materials. In particular, the proposed method is based on the use of amorphous silica contained in rice husk ash (RHA), an agricultural byproduct material (COSMOS-RICE project). The obtained final inert can be applied in several applications to produce “green composites”. In this work, for the first time, a process for pre-treatment of rice husk, before its use in the stabilization of heavy metals, based on the employment of Instant Pressure Drop technology (DIC) was tested. The aim of this work is to verify the influence of the pre-treatment on the efficiency on heavy metals stabilization in the COSMOS-RICE technology. DIC technique is based on a thermomechanical effect induced by an abrupt transition from high steam pressure to a vacuum, to produce changes in the material. Two different DIC pre-treatments were selected and thermal annealing at different temperatures were performed on rice husk. The resulting RHAs were employed to obtain COSMOS-RICE samples, and the stabilization procedure was tested on the MSWI fly ash. In the frame of this work, some thermal treatments were also realized in O2-limiting conditions, to test the effect of charcoal obtained from RHA on the stabilization procedure. The results of this work show that the application of DIC technology into existing treatment cycles of some waste materials should be investigated in more details to offer the possibility to stabilize and reuse waste. PMID:28793605

  20. Surveying and optical tooling technologies combined to align a skewed beamline at the LAMPF accelerator

    International Nuclear Information System (INIS)

    Bauke, W.; Clark, D.A.; Trujillo, P.B.

    1985-01-01

    Optical Tooling evolved from traditional surveying, and both technologies are sometimes used interchangeably in large industrial installations, since the instruments and their specialized adapters and supports complement each other well. A unique marriage of both technologies was accomplished in a novel application at LAMPF, the Los Alamos Meson Physics Facility. LAMPF consists of a linear accelerator with multiple target systems, one of which had to be altered to accommodate a new beamline for a neutrino experiment. The new line was to be installed into a crowded beam tunnel and had to be skewed and tilted in compound angles to avoid existing equipment. In this paper we describe how Optical Tooling was used in conjunction with simple alignment and reference fixtures to set fiducials on the magnets and other mechanical components of the beamline, and how theodolites and sight levels were then adapted to align these components along the calculated skew planes. Design tolerances are compared with measured alignment results

  1. Combining Ground-Truthing and Technology to Improve Accuracy in Establishing Children's Food Purchasing Behaviors.

    Science.gov (United States)

    Coakley, Hannah Lee; Steeves, Elizabeth Anderson; Jones-Smith, Jessica C; Hopkins, Laura; Braunstein, Nadine; Mui, Yeeli; Gittelsohn, Joel

    Developing nutrition-focused environmental interventions for youth requires accurate assessment of where they purchase food. We have developed an innovative, technology-based method to improve the accuracy of food source recall among children using a tablet PC and ground-truthing methodologies. As part of the B'more Healthy Communties for Kids study, we mapped and digitally photographed every food source within a half-mile radius of 14 Baltimore City recreation centers. This food source database was then used with children from the surrounding neighborhoods to search for and identify the food sources they frequent. This novel integration of traditional data collection and technology enables researchers to gather highly accurate information on food source usage among children in Baltimore City. Funding is provided by the NICHD U-54 Grant #1U54HD070725-02.

  2. Combining sun-based technologies (microalgae and solar disinfection) for urban wastewater regeneration.

    Science.gov (United States)

    Gutiérrez-Alfaro, Sergio; Rueda-Márquez, Juan J; Perales, José A; Manzano, Manuel A

    2018-04-01

    Solar disinfection (SODIS) of urban wastewater can be a suitable technology for improving the microbiological quality of reclaimed water as a complement to other extensive and environmentally friendly technologies such as microalgae biotreatment. The objective of this work is to evaluate the feasibility of incorporating the SODIS technology at the end of a pilot scale urban wastewater treatment plant (WWTP) where the processes are based on microalgae biotechnology and comprising three Upflow Anaerobic Sludge Blanket (UASB, 20m 3 each one) reactor, six High Rate Algal Ponds (HRAP, 32m 2 each one), and a Dissolved Air Flotation (DAF, 1m 3 ) unit. E. coli concentration was monitored at the effluent of the different units (UASB, HRAP, DAF) of the pilot WWTP. The efficiency of the SODIS process was studied for the inactivation of three of the commonly employed indicator microorganisms (Escherichia coli, Enterococcus spp. and Clostridium perfringens) using a compound parabolic collector (CPC) for five months under various conditions of irradiance and temperature. E. coli and Enterococcus spp. were more effectively disinfected by the SODIS unit (2.9 and 2.5 logarithms of reduction on average, respectively) than by the HRAP (2 and 1.1) or the DAF (0.9 and 0.1). On the contrary, the DAF technology achieved better reduction rates of C. perfringens (1.7) than the SODIS (0.9) and the HRAP (0.1). No regrowth of any microorganisms was detected during dark storage after the SODIS treatment. Incorporating a SODIS unit after the non-conventional WWTP processes substantially increases the possibilities for reuse of the treated water after receiving a cumulative UV radiation dose of 25W·h/m 2 (50min of normalized time of solar illumination). The surface requirement of the SODIS equipment would be 3.5 times smaller than the HRAP's surface. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. A microencapsulation process of liquid mercury by sulfur polymer stabilization/solidification technology. Part II: Durability of materials

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Delgado, A.; Guerrero, A.; Lopez, F. A.; Perez, C.; Alguacil, F. J.

    2012-11-01

    Under the European LIFE Program a microencapsulation process was developed for liquid mercury using Sulfur Polymer Stabilization/Solidification (SPSS) technology, obtaining a stable concrete-like sulfur matrix that allows the immobilization of mercury for long-term storage. The process description and characterization of the materials obtained were detailed in Part I. The present document, Part II, reports the results of different tests carried out to determine the durability of Hg-S concrete samples with very high mercury content (up to 30 % w/w). Different UNE and RILEM standard test methods were applied, such as capillary water absorption, low pressure water permeability, alkali/acid resistance, salt mist aging, freeze-thaw resistance and fire performance. The samples exhibited no capillarity and their resistance in both alkaline and acid media was very high. They also showed good resistance to very aggressive environments such as spray salt mist, freeze-thaw and dry-wet. The fire hazard of samples at low heat output was negligible. (Author)

  4. Literacity: A multimedia adult literacy package combining NASA technology, recursive ID theory, and authentic instruction theory

    Science.gov (United States)

    Willis, Jerry; Willis, Dee Anna; Walsh, Clare; Stephens, Elizabeth; Murphy, Timothy; Price, Jerry; Stevens, William; Jackson, Kevin; Villareal, James A.; Way, Bob

    1994-01-01

    An important part of NASA's mission involves the secondary application of its technologies in the public and private sectors. One current application under development is LiteraCity, a simulation-based instructional package for adults who do not have functional reading skills. Using fuzzy logic routines and other technologies developed by NASA's Information Systems Directorate and hypermedia sound, graphics, and animation technologies the project attempts to overcome the limited impact of adult literacy assessment and instruction by involving the adult in an interactive simulation of real-life literacy activities. The project uses a recursive instructional development model and authentic instruction theory. This paper describes one component of a project to design, develop, and produce a series of computer-based, multimedia instructional packages. The packages are being developed for use in adult literacy programs, particularly in correctional education centers. They use the concepts of authentic instruction and authentic assessment to guide development. All the packages to be developed are instructional simulations. The first is a simulation of 'finding a friend a job.'

  5. Solar education combining art, history, science and technology at archaeological sites in Italy

    Energy Technology Data Exchange (ETDEWEB)

    Silvi, C.; Ferro, P. [ISES (Italy); Ceccarini, T. [Educational Section - State Superintendence of Archaeological Monuments in Rome (Italy)

    2004-07-01

    ''Solar Art and Solar Technologies'' and ''Solar Energy by studying Ancient Architecture'' laboratory promoted by ISES ITALIA and the Educational Section of the State Superintendence of Archaeological Monuments in Rome involved from 2000 to 2004 roughly 1000 schoolchildren, 20 teachers and five archaeologists. For its innovative character and its special approach to solar education, the exhibition ''Solar Art and Technologies'' has been acknowledged among the 50 best projects of the ''2001 Energy Globe Award.'' The program has been continuously improved and has broadened its educational reach beyond schoolchildren. The experiences made at the archaeological sites from the energy point of view lead to new research projects and initiatives on solar energy at the archaeological sites during the excavations, while exploring historical sources, and at the involved schools. A seminar on ''Solar energy and the built environment in past civilizations'' will be held at the end of May 2004 to review historical sources and the most recent archaeological discoveries that have relation with solar architecture and technology. The seminar will also address the possible participation of historians and archaeologists in the history sessions planned at ISES 2005 (www.swc2005.org). (orig.)

  6. Empowering users through design interdisciplinary studies and combined approaches for technological products and services

    CERN Document Server

    2015-01-01

    At the crossroads of various disciplines, this collective work examines the possibility of a new end-user “engagement” in ongoing digital/technological products and services development. It provides an overview of recent research specifically focused on the user’s democratic participation and empowerment. It also enables readers to better identify the main opportunities of participatory design, a concept which encourages the blurring of the role between user and designer. This allows people to escape their status as “end-user” and to elevate themselves to the level of creator. This book explores new avenues for rethinking the processes and practices of corporate innovation in order to cope with current socio-economic and technological changes. In so doing, it aims to help companies renew industrial models that allow them to design and produce new ranges of technological products and services by giving the user an active role in the development process, far beyond the basic role of consumer. Intended...

  7. MnNi-based spin valve sensors combining high thermal stability, small footprint and pTesla detectivities

    Science.gov (United States)

    Silva, Marília; Leitao, Diana C.; Cardoso, Susana; Freitas, Paulo

    2018-05-01

    Magnetoresistive sensors with high thermal robustness, low noise and high spatial resolution are the answer to a number of challenging applications. Spin valve sensors including MnNi as antiferromagnet layer provide higher exchange bias field and improved thermal stability. In this work, the influence of the buffer layer type (Ta, NiFeCr) and thickness on key sensor parameters (e.g. offset field, Hf) is investigated. A Ta buffer layer promotes a strong (111) texture which leads to a higher value of MR. In contrast, Hf is lower for NiFeCr buffer. Micrometric sensors display thermal noise levels of 1 nT/Hz1/2 and 571 pT/Hz1/2 for a sensor height (h) of 2 and 4 μm, respectively. The temperature dependence of MR and sensitivity is also addressed and compared with MnIr based spin valves. In this case, MR abruptly decreases after heating at 160°C (without magnetic field), contrary to MnNi-based spin valves, where only a 10% MR decrease (relative to the initial value) is seen at 275°C. Finally, to further decrease the noise levels and improve detectivity, MnNi spin-valves are deposited vertically, and connected in parallel and series (in-plane) to create a device with low resistance and high sensitivity. A field detection at thermal level of 346 pT/Hz1/2 is achieved for a device with a total of 300 SVs (4 vertical, 15 in series, 5 in parallel).

  8. ESTABLISHING SUSTAINABLE US HEV/PHEV MANUFACTURING BASE: STABILIZED LITHIUM METAL POWDER, ENABLING MATERIAL AND REVOLUTIONARY TECHNOLOGY FOR HIGH ENERGY LI-ION BATTERIES

    Energy Technology Data Exchange (ETDEWEB)

    Yakovleva, Marina

    2012-12-31

    FMC Lithium Division has successfully completed the project “Establishing Sustainable US PHEV/EV Manufacturing Base: Stabilized Lithium Metal Powder, Enabling Material and Revolutionary Technology for High Energy Li-ion Batteries”. The project included design, acquisition and process development for the production scale units to 1) produce stabilized lithium dispersions in oil medium, 2) to produce dry stabilized lithium metal powders, 3) to evaluate, design and acquire pilot-scale unit for alternative production technology to further decrease the cost, and 4) to demonstrate concepts for integrating SLMP technology into the Li- ion batteries to increase energy density. It is very difficult to satisfy safety, cost and performance requirements for the PHEV and EV applications. As the initial step in SLMP Technology introduction, industry can use commercially available LiMn2O4 or LiFePO4, for example, that are the only proven safer and cheaper lithium providing cathodes available on the market. Unfortunately, these cathodes alone are inferior to the energy density of the conventional LiCoO2 cathode and, even when paired with the advanced anode materials, such as silicon composite material, the resulting cell will still not meet the energy density requirements. We have demonstrated, however, if SLMP Technology is used to compensate for the irreversible capacity in the anode, the efficiency of the cathode utilization will be improved and the cost of the cell, based on the materials, will decrease.

  9. Some technological aspects of combined processing of meat by heat and ionizing radiations

    International Nuclear Information System (INIS)

    Gel'fand, S.Yu.; Nomenotskaya, N.F.; Mozul', M.Ya.

    1974-01-01

    The paper discusses the use of ionizing radiation to prolong the storage life of meat and meat products. Irradiating raw meat with doses of 0.4-0.6 Mrad increased storage life up to two months at low above-zero C temperatures. The difficulty of inhibiting autolytic processes during storage of irradiated raw meat led to searches for combined methods of meat treatment. A series of experiments was staged with pre-irradiation heating of meat up to 75, 77, and 80 0 C in order to see how cathepsin activity is affected by the duration and temperature of heating in the case of combined treatment. To increase the resistance of meat products to microbial damage, tests were carried out in which meat was exposed to short-term but intensive heat by immersing it in hot (130-160 0 C) vegetable oil (frying grease). The results are presented in the form of tables and diagrams. (E.T.)

  10. Application of surface–downhole combined microseismic monitoring technology in the Fuling shale gas field and its enlightenment

    Directory of Open Access Journals (Sweden)

    Yaowen Liu

    2017-01-01

    Full Text Available The Fuling shale gas field in the Sichuan Basin, as a national shale gas demonstration area, is the largest commercially developed shale gas field in the world except those in North America. The fracturing technology in the mode of “well factory” has been applied widely in the gas field, but it is necessary to perform further investigation on the way to evaluate effectively the fracturing effect of multi-well platform “well factory” and the distribution laws of its induced fracture networks. In this paper, the fractures induced by the “well factory” at the JY 48 platform were real-time monitored by a surface–downhole combined microseismic monitoring technology. The geometric size and extension direction of artificial fractures induced in the model of “well factory” fracturing in the Jiaoshiba block of Fuling Shale Gas Field were preliminarily understood. Moreover, the fracturing parameters under the mode of “well factory” were recognized by using the comprehensive interpretation results of surface–downhole combined microseismic monitoring technology, together with the SRV fracturing prediction chart. Eventually, the distribution laws of artificial fractures during the “well-factory-zipper” fracturing in the Fuling Shale Gas Field were clarified definitely. This paper provides guidance for the optimization of fracturing parameters at the later stage.

  11. Combination of existing and alternative technologies to promote oilseeds and pulses proteins in food applications

    OpenAIRE

    Chéreau Denis; Videcoq Pauline; Ruffieux Cécile; Pichon Lisa; Motte Jean-Charles; Belaid Saliha; Ventureira Jorge; Lopez Michel

    2016-01-01

    The continuous world population growth induces a total protein demand increase based mainly on plant sources. To meet these global nutritional challenges, existing and innovative dry and wet fractionation processes will have to be combined to better valorise plant protein fraction from pulses and oilseeds. The worldwide success of soy protein isolates originate from the intrinsic qualities of soybean proteins but also from a con...

  12. DSM-flux: A new technology for reliable Combined Sewer Overflow discharge monitoring with low uncertainties.

    Science.gov (United States)

    Maté Marín, Ainhoa; Rivière, Nicolas; Lipeme Kouyi, Gislain

    2018-06-01

    In the past ten years, governments from the European Union have been encouraged to collect volume and quality data for all the effluent overflows from separated stormwater and combined sewer systems that result in a significant environmental impact on receiving water bodies. Methods to monitor and control these flows require improvements, particularly for complex Combined Sewer Overflow (CSO) structures. The DSM-flux (Device for Stormwater and combined sewer flows Monitoring and the control of pollutant fluxes) is a new pre-designed and pre-calibrated channel that provides appropriate hydraulic conditions suitable for measurement of overflow rates and volumes by means of one water level gauge. In this paper, a stage-discharge relation for the DSM-flux is obtained experimentally and validated for multiple inflow hydraulic configurations. Uncertainties in CSO discharges and volumes are estimated within the Guide to the expression of Uncertainty in Measurement (GUM) framework. Whatever the upstream hydraulic conditions are, relative uncertainties are lower than 15% and 2% for the investigated discharges and volumes, respectively. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. The combined effect of food-simulating solutions, brushing and staining on color stability of composite resins

    Science.gov (United States)

    Silva, Tânia Mara Da; Sales, Ana Luísa Leme Simões; Pucci, Cesar Rogerio; Borges, Alessandra Bühler; Torres, Carlos Rocha Gomes

    2017-01-01

    Abstract Objective: This study evaluated the effect of food-simulating media associated with brushing and coffee staining on color stability of different composite resins. Materials and methods: Eighty specimens were prepared for each composite: Grandio SO (Voco), Amaris (Voco), Filtek Z350XT (3M/ESPE), Filtek P90 (3M/ESPE). They were divided into four groups according to food-simulating media for 7 days: artificial saliva (control), heptane, citric acid and ethanol. The composite surface was submitted to 10,950 brushing cycles (200 g load) in an automatic toothbrushing machine. The specimens were darkened with coffee solution at 37 °C for 24 h. After each treatment, color measurements were assessed by spectrophotometry, using CIE L*a*b* system. The overall color change (ΔE) was determined for each specimen at baseline (C1) and after the treatments (food-simulating media immersion/C2, brushing/C3 and dye solution/C4). Data were analyzed by two-way repeated measures ANOVA and Tukey’s tests (p composites (p = .001), time (p = .001) and chemical degradation (p = .002). The mean of ΔE for composites were: Z350XT (5.39)a, Amaris (3.89)b, Grandio (3.75)bc, P90 (3.36)c. According to food-simulating media: heptane (4.41)a, citric acid (4.24)a, ethanol (4.02)ab, artificial saliva (3.76)b. For the treatments: dye solution (4.53)a, brushing (4.26)a, after food-simulating media (3.52)b. Conclusions: The composite resin Filtek Z350XT showed significantly higher staining than all other composite resin tested. The immersion in heptane and citric acid produced the highest color alteration than other food-simulating media. The exposure of samples to brushing protocols and darkening in coffee solution resulted in significant color alteration of the composite resins. PMID:28642926

  14. Modeling technology innovation: how science, engineering, and industry methods can combine to generate beneficial socioeconomic impacts.

    Science.gov (United States)

    Stone, Vathsala I; Lane, Joseph P

    2012-05-16

    Government-sponsored science, technology, and innovation (STI) programs support the socioeconomic aspects of public policies, in addition to expanding the knowledge base. For example, beneficial healthcare services and devices are expected to result from investments in research and development (R&D) programs, which assume a causal link to commercial innovation. Such programs are increasingly held accountable for evidence of impact-that is, innovative goods and services resulting from R&D activity. However, the absence of comprehensive models and metrics skews evidence gathering toward bibliometrics about research outputs (published discoveries), with less focus on transfer metrics about development outputs (patented prototypes) and almost none on econometrics related to production outputs (commercial innovations). This disparity is particularly problematic for the expressed intent of such programs, as most measurable socioeconomic benefits result from the last category of outputs. This paper proposes a conceptual framework integrating all three knowledge-generating methods into a logic model, useful for planning, obtaining, and measuring the intended beneficial impacts through the implementation of knowledge in practice. Additionally, the integration of the Context-Input-Process-Product (CIPP) model of evaluation proactively builds relevance into STI policies and programs while sustaining rigor. The resulting logic model framework explicitly traces the progress of knowledge from inputs, following it through the three knowledge-generating processes and their respective knowledge outputs (discovery, invention, innovation), as it generates the intended socio-beneficial impacts. It is a hybrid model for generating technology-based innovations, where best practices in new product development merge with a widely accepted knowledge-translation approach. Given the emphasis on evidence-based practice in the medical and health fields and "bench to bedside" expectations for

  15. Structural changes and thermal stability of charged LiNixMnyCozO₂ cathode materials studied by combined in situ time-resolved XRD and mass spectroscopy.

    Science.gov (United States)

    Bak, Seong-Min; Hu, Enyuan; Zhou, Yongning; Yu, Xiqian; Senanayake, Sanjaya D; Cho, Sung-Jin; Kim, Kwang-Bum; Chung, Kyung Yoon; Yang, Xiao-Qing; Nam, Kyung-Wan

    2014-12-24

    Thermal stability of charged LiNixMnyCozO2 (NMC, with x + y + z = 1, x:y:z = 4:3:3 (NMC433), 5:3:2 (NMC532), 6:2:2 (NMC622), and 8:1:1 (NMC811)) cathode materials is systematically studied using combined in situ time-resolved X-ray diffraction and mass spectroscopy (TR-XRD/MS) techniques upon heating up to 600 °C. The TR-XRD/MS results indicate that the content of Ni, Co, and Mn significantly affects both the structural changes and the oxygen release features during heating: the more Ni and less Co and Mn, the lower the onset temperature of the phase transition (i.e., thermal decomposition) and the larger amount of oxygen release. Interestingly, the NMC532 seems to be the optimized composition to maintain a reasonably good thermal stability, comparable to the low-nickel-content materials (e.g., NMC333 and NMC433), while having a high capacity close to the high-nickel-content materials (e.g., NMC811 and NMC622). The origin of the thermal decomposition of NMC cathode materials was elucidated by the changes in the oxidation states of each transition metal (TM) cations (i.e., Ni, Co, and Mn) and their site preferences during thermal decomposition. It is revealed that Mn ions mainly occupy the 3a octahedral sites of a layered structure (R3̅m) but Co ions prefer to migrate to the 8a tetrahedral sites of a spinel structure (Fd3̅m) during the thermal decomposition. Such element-dependent cation migration plays a very important role in the thermal stability of NMC cathode materials. The reasonably good thermal stability and high capacity characteristics of the NMC532 composition is originated from the well-balanced ratio of nickel content to manganese and cobalt contents. This systematic study provides insight into the rational design of NMC-based cathode materials with a desired balance between thermal stability and high energy density.

  16. Combined jugular and subclavian vein thrombosis following assisted reproductive technology--new observation.

    Science.gov (United States)

    Salomon, Ophira; Schiby, Ginette; Heiman, Zehava; Avivi, Kamila; Sigal, Carol; Levran, David; Dor, Jeushua; Itzchak, Yacov

    2009-08-01

    To study the predilection of jugular and subclavian vein thrombosis in patients going through assisted reproductive technology (ART). This technology puts women at high risk of developing the ovarian hyperstimulation syndrome (OHSS) and thrombotic events. Study cases. Large Academic Medical Center. Five women who developed jugular and subclavian vein thrombosis following ART were included in the study. The deep vein thrombosis was demonstrated by ultrasound Doppler or computerized tomography angiography. All women were interviewed and data obtained from outpatient and hospital medical charts. Magnetic resonance imaging and complete thrombophilic profile workup was performed in each woman. Open biopsy from the lesions was taken from one of the women. Correlation between mechanical branchial cysts filled with fluid during OHSS and jugular and subclavian vein thrombosis. Five women developed jugular and subclavian vein thrombosis following ART. They were found to harbor clusters of rudimentary branchial cysts filled with fluid at the time of OHSS, which compressed the jugular and subclavian veins at their junction at the base of the neck. Four patients (80%) were found to be carriers of factor V Leiden. Predilection of jugular and subclavian vein thrombosis early in pregnancy is the result of mechanical compression mediated by rudimentary branchial cysts filled with fluid during OHSS, particularly in subjects who are carriers of factor V Leiden.

  17. Proof-of-principle study of a small animal PET/field-cycled MRI combined system using conventional PMT technology

    International Nuclear Information System (INIS)

    Peng Hao; Handler, William B.; Scholl, Timothy J.; Simpson, P.J.; Chronik, Blaine A.

    2010-01-01

    There are currently several approaches to the development of combined PET/MRI systems, all of which need to address adverse interactions between the two systems. Of particular relevance to the majority of proposed PET/MRI systems is the effect that static and dynamic magnetic fields have on the performance of PET detection systems based on photomultiplier tubes (PMTs). In the work reported in this paper, performance of two conventional PMTs has been systematically investigated and characterized as a function of magnetic field exposure conditions. Detector gain, energy resolution, time resolution, and efficiency were measured for static field exposures between 0 and 6.3 mT. Additionally, the short-term recovery and long-term stability of gain and energy resolution were measured in the presence of repeatedly applied dynamic magnetic fields changing at 4 T/s. It was found that the detectors recovered normal operation within several milliseconds following the end of large pulsed magnetic fields. In addition, the repeated applications of large pulsed magnetic fields did not significantly affect detector stability. Based on these results, we implemented a proof-of-principle PET/field-cycled MRI (FCMRI) system for small animal imaging using commercial PMT-based PET detectors. The first PET images acquired within the PET/FCMRI system are presented. The image quality, in terms of spatial resolution, was compared between standalone PET and the PET/FCMRI system. Finally, the relevance of these results to various aspects of PET/MRI system design is discussed.

  18. Inventory of future power and heat production technologies. Partial report Energy combines

    International Nuclear Information System (INIS)

    Thunman, Henrik; Lind, Fredrik; Johnsson, Filip

    2008-12-01

    This report treats different ways to produce various upgraded biofuels from lignocellulosic materials in so called polygeneration processes. Furthermore the different upgrading technologies are also investigated with respect to co-production of heat and power. The processes investigated are linked to production of - bio pellets (or lignin pellets), dried, grinded and compressed biomass (or lignin); - torrified bio pellets, dried, grinded, heat treated and compressed biomass; - bio-oils or pyrolytic oils, liquefied biomass with crude oil quality; - ethanol via hydrolysis (process where the biomass is divided into sugars and lignin) followed by fermentation; - methane via hydrolysis and fermentation; - methane via indirect gasification and methane via indirect or suspension gasification, - DME (dimethyl ether) via indirect or suspension gasification; - methanol via indirect or suspension gasification; - DME and methanol via methane produced via indirect gasification. Lignocellulosic biomasses are, for example, forest residues or biomass that can be cultivated on degraded lands. The result from this report shows that it is only the production of bio pellets that is fully commercially available today. For all the other polygeneration processes investigated the production of bio-oil and torrified bio pellets stands out from the other processes investigated, as it is the market for the product that holds back the introduction of the technology. For the other technologies one or several components are still not commercialized and the challenges for these technologies are described in the report. Summarizing the efficiencies for the different processes, the processes that produces biofuels for stationary applications, bio pellets, torrified bio pellets and bio-oil, show the highest efficiencies. Accounted for the co-generated power, efficiencies up to 90 % based on ingoing lower heating values of the dry substance fed to the process could be achieved. For the processes

  19. A hybrid MCDM framework combined with DEMATEL-based ANP to evaluate enterprise technological innovation capabilities assessment

    Directory of Open Access Journals (Sweden)

    Meng-Jong Kuan

    2014-08-01

    Full Text Available The efficient evaluation of technological innovation capabilities of enterprises is an important factor to enhance competitiveness. This paper aims to assess and to rank technological innovation evaluation criteria in order to provide a practical insight of systematic analysis by gathering the qualified experts’ opinions combined with three methods of multi-criteria decision making approach. A framework is proposed and uses a novel hybrid multiple criteria decision-making (MCDM model to address the dependence relationships of criteria with the aid of the Decision-Making Trial and Evaluation Laboratory (DEMATEL, analytical network process (ANP and VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje. The study reports that the interaction between criteria is essential and influences technological innovation capabilities; furthermore, this ranking development of technological innovation capabilities assessment is also one of key management tools for managements of other related high- tech enterprises. Managers can then judge the need to improve and determine which criteria provide the most effective direction towards improvement.

  20. Adaptive Opportunistic Cooperative Control Mechanism Based on Combination Forecasting and Multilevel Sensing Technology of Sensors for Mobile Internet of Things

    Directory of Open Access Journals (Sweden)

    Yong Jin

    2014-01-01

    Full Text Available In mobile Internet of Things, there are many challenges, including sensing technology of sensors, how and when to join cooperative transmission, and how to select the cooperative sensors. To address these problems, we studied the combination forecasting based on the multilevel sensing technology of sensors, building upon which we proposed the adaptive opportunistic cooperative control mechanism based on the threshold values such as activity probability, distance, transmitting power, and number of relay sensors, in consideration of signal to noise ratio and outage probability. More importantly, the relay sensors would do self-test real time in order to judge whether to join the cooperative transmission, for maintaining the optimal cooperative transmission state with high performance. The mathematical analyses results show that the proposed adaptive opportunistic cooperative control approach could perform better in terms of throughput ratio, packet error rate and delay, and energy efficiency, compared with the direct transmission and opportunistic cooperative approaches.

  1. Combining Education and Practice Learning in Environmental Management and Cleaner Technology

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik; Jørgensen, Michael Søgaard

    2004-01-01

    to overcome these problems are discussed. The educational principles are presented as a combination of educational learning and practice learning named as reflexive learning. The experience from working with reflexive learning is discussed and relation to the role it can play in creating profes......This chapter argues for a new role for universities in adding the training of (existing) professionals to the core agenda in parallel to academic education and scientific research. Based on experiences from Denmark new challenges both to academic knowledge and training are presented and way...

  2. The consolidation of a powder material in conditions of combined influence of different technological factors

    Directory of Open Access Journals (Sweden)

    Dorofeyev V.Yu.

    2003-01-01

    Full Text Available In the present paper the problems, connected with the formation of a powder material and its surface layers in conditions of chemical thermal treatment and impregnation with melt, combined with the use of mechanical loads at different process stages are examined. The new results of liquid phase influence on compaction of powder preforms, subjected to impregnation, are obtained. The presence of a liquid phase in preform surface layers can also be connected with the change of the materials chemical composition as the result of boronizing, siliconizing or other kinds of chemical thermal treatment.

  3. [Rapid Identification of Epicarpium Citri Grandis via Infrared Spectroscopy and Fluorescence Spectrum Imaging Technology Combined with Neural Network].

    Science.gov (United States)

    Pan, Sha-sha; Huang, Fu-rong; Xiao, Chi; Xian, Rui-yi; Ma, Zhi-guo

    2015-10-01

    To explore rapid reliable methods for detection of Epicarpium citri grandis (ECG), the experiment using Fourier Transform Attenuated Total Reflection Infrared Spectroscopy (FTIR/ATR) and Fluorescence Spectrum Imaging Technology combined with Multilayer Perceptron (MLP) Neural Network pattern recognition, for the identification of ECG, and the two methods are compared. Infrared spectra and fluorescence spectral images of 118 samples, 81 ECG and 37 other kinds of ECG, are collected. According to the differences in tspectrum, the spectra data in the 550-1 800 cm(-1) wavenumber range and 400-720 nm wavelength are regarded as the study objects of discriminant analysis. Then principal component analysis (PCA) is applied to reduce the dimension of spectroscopic data of ECG and MLP Neural Network is used in combination to classify them. During the experiment were compared the effects of different methods of data preprocessing on the model: multiplicative scatter correction (MSC), standard normal variable correction (SNV), first-order derivative(FD), second-order derivative(SD) and Savitzky-Golay (SG). The results showed that: after the infrared spectra data via the Savitzky-Golay (SG) pretreatment through the MLP Neural Network with the hidden layer function as sigmoid, we can get the best discrimination of ECG, the correct percent of training set and testing set are both 100%. Using fluorescence spectral imaging technology, corrected by the multiple scattering (MSC) results in the pretreatment is the most ideal. After data preprocessing, the three layers of the MLP Neural Network of the hidden layer function as sigmoid function can get 100% correct percent of training set and 96.7% correct percent of testing set. It was shown that the FTIR/ATR and fluorescent spectral imaging technology combined with MLP Neural Network can be used for the identification study of ECG and has the advantages of rapid, reliable effect.

  4. A combination of grapefruit seed extract and concentrated cranberry juice as a potential antimicrobial preservative for the improvement of microbiological stability of hypromellose gel.

    Science.gov (United States)

    Bernatoniene, Jurga; Keraitė, Rasa; Masteiková, Ruta; Pavilonis, Alvydas; Savickas, Arūnas

    2013-10-01

    Aqueous hypromellose gels are not microbiologically stable - they show signs of microorganism growth during storage. To extend the shelf-life of the gels, antimicrobial preservatives are needed. Some substances of plant origin are known for their antimicrobial properties, and thus they may be used as an alternative to synthetic preservatives. Therefore, the aim of this study was to evaluate the microbiological stability of aqueous hypromellose gel and the effectiveness of natural substances - grapefruit seed extract (GSE), concentrated cranberry juice, and a combination thereof - on the antimicrobial protection of the gel. The evaluation of the antimicrobial activity of GSE and cranberry juice showed that their antimicrobial effects differed. Both cranberry juice and GSE inhibited the growth of the standard gram-positive and gram-negative bacteria, but the effect of GSE was significantly stronger. Candida albicans was sensitive only to GSE. For this reason, in order to affect all the microorganisms studied, either a combination of 0.7% GSE and 10% cranberry juice, or 5% GSE alone may be used. The combination of GSE and cranberry juice was effective only in acidic medium (pH being 2.5-5), while the antimicrobial effect of GSE was not dependent on the pH value.

  5. Improving Performance and Operational Stability of Porcine Interferon-α Production by Pichia pastoris with Combinational Induction Strategy of Low Temperature and Methanol/Sorbitol Co-feeding.

    Science.gov (United States)

    Gao, Min-Jie; Zhan, Xiao-Bei; Gao, Peng; Zhang, Xu; Dong, Shi-Juan; Li, Zhen; Shi, Zhong-Ping; Lin, Chi-Chung

    2015-05-01

    Various induction strategies were investigated for effective porcine interferon-α (pIFN-α) production by Pichia pastoris in a 10 L fermenter. We found that pIFN-α concentration could be significantly improved with the strategies of low-temperature induction or methanol/sorbitol co-feeding. On this basis, a combinational strategy of induction at lower temperature (20 °C) with methanol/sorbitol co-feeding has been proposed for improvement of pIFN-α production. The results reveal that maximal pIFN-α concentration and antiviral activity reach the highest level of 2.7 g/L and 1.8 × 10(7) IU/mg with the proposed induction strategy, about 1.3-2.1 folds higher than those obtained with other sub-optimal induction strategies. Metabolic analysis and online multi-variable measurement results indicate that energy metabolic enrichment is responsible for the performance enhancement of pIFN-α production, as a large amount of ATP could be simultaneously produced from both formaldehyde oxidation pathway in methanol metabolism and tricarboxylic acid (TCA) cycle in sorbitol metabolism. In addition, the proposed combinational induction strategy enables P. pastoris to be resistant to high methanol concentration (42 g/L), which conceivably occur associating with the error-prone methanol over-feeding. As a result, the proposed combinational induction strategy simultaneously increased the targeted protein concentration and operational stability leading to significant improvement of pIFN-α production.

  6. Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level

    Directory of Open Access Journals (Sweden)

    Riggio Cristina

    2009-01-01

    Full Text Available Abstract In this article, a carbon nanotube (CNT array-based system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent (neural growth factor, NGF. PC12 cell differentiation, following incubation on the CNT array embedding the alginate delivery film, demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces, combining several functions into a single platform.

  7. Combined cycles, impacts of technological requirements; Ciclos combinados, impactos de requerimientos tecnologicos

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Santalo, Jose Miguel [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    1999-07-01

    The fundamental growth of the Mexican electrical sector for the next ten years is planned on base of the installation of 20 thousand Mw plants of combined cycle. This article presents an analysis of the impact of these power stations finding out that the power stations of combined cycle are at the moment cheaper - from 600 to 700 dollars by installed kW- than the alternative coal options or fuel oil, that are in the range of 900 to 1200 dollars per kW, in addition to which the time required for their construction is shorter. [Spanish] El crecimiento fundamental del sector electrico mexicano para los proximos diez anos esta planeado con base en la instalacion de 20 mil Mw de plantas de ciclo combinado. Este articulo presenta un analisis del impacto de dichas centrales encontrando que las centrales de ciclo combinado actualmente resultan mas baratas - de 600 a 700 dolares por kW instalado - que las opciones alternativas de carbon o combustoleo que estan en el rango de 900 a 1200 dolares por kW, ademas de que los tiempos requeridos para su construccion son menores.

  8. The effect of a combined glenoid and Hill-Sachs defect on glenohumeral stability: a biomechanical cadaveric study using 3-dimensional modeling of 142 patients.

    Science.gov (United States)

    Arciero, Robert A; Parrino, Anthony; Bernhardson, Andrew S; Diaz-Doran, Vilmaris; Obopilwe, Elifho; Cote, Mark P; Golijanin, Petr; Mazzocca, Augustus D; Provencher, Matthew T

    2015-06-01

    Bone loss in anterior glenohumeral instability occurs on both the glenoid and the humerus; however, existing biomechanical studies have evaluated glenoid and humeral head defects in isolation. Thus, little is known about the combined effect of these bony lesions in a clinically relevant model on glenohumeral stability. The purpose of this study was to determine the biomechanical efficacy of a Bankart repair in the setting of bipolar (glenoid and humeral head) bone defects determined via computer-generated 3-dimensional (3D) modeling of 142 patients with recurrent anterior shoulder instability. The null hypothesis was that adding a bipolar bone defect will have no effect on glenohumeral stability after soft tissue Bankart repair. Controlled laboratory study. A total of 142 consecutive patients with recurrent anterior instability were analyzed with 3D computed tomography scans. Two Hill-Sachs lesions were selected on the basis of volumetric size representing the 25th percentile (0.87 cm(3); small) and 50th percentile (1.47 cm(3); medium) and printed in plastic resin with a 3D printer. A total of 21 cadaveric shoulders were evaluated on a custom shoulder-testing device permitting 6 degrees of freedom, and the force required to translate the humeral head anteriorly 10 mm at a rate of 2.0 mm/s with a compressive load of 50 N was determined at 60° of glenohumeral abduction and 60° of external rotation. All Bankart lesions were made sharply from the 2- to 6-o'clock positions for a right shoulder. Subsequent Bankart repair with transosseous tunnels using high-strength suture was performed. Hill-Sachs lesions were made in the cadaver utilizing a plastic mold from the exact replica off the 3D printer. Testing was conducted in the following sequence for each specimen: (1) intact, (2) posterior capsulotomy, (3) Bankart lesion, (4) Bankart repair, (5) Bankart lesion with 2-mm glenoid defect, (6) Bankart repair, (7) Bankart lesion with 2-mm glenoid defect and Hill-Sachs lesion

  9. Succeeding in deep water by combining technology qualification and production forecasting

    Energy Technology Data Exchange (ETDEWEB)

    Hussain, A.; Oiungen, B.; Raposo, C. [Det Norske Veritas (DNV), Rio de Janeiro, RJ (Brazil)

    2008-07-01

    All the easy oil and gas is gone, and, as a result the Oil and Gas industry is continuously targeting deeper and more remote fields. The exploration and development of deep water oil and gas fields is associated with enormous costs and multiple uncertainties with regard to equipment reliability and performance. Proper risk management can be used to evaluate the impact of these uncertainties thereby helping to ensure optimal business performance of the future assets, as well as helping the decision maker target investment towards areas where the financial impact will be the greatest. This paper reviews the principles of Technology Qualification and Production Forecasting methodology, both of which are risk management solutions with a proven track record for deep water field developments. (author)

  10. Combining X-ray based methods to study the protohistoric bronze technology in Western Iberia

    Energy Technology Data Exchange (ETDEWEB)

    Valério, P., E-mail: pvalerio@ctn.ist.utl.pt [Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS (Portugal); Silva, R.J.C., E-mail: rjcs@fct.unl.pt [CENIMAT/I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa, 2829-516 Monte de Caparica (Portugal); Soares, A.M.M., E-mail: amsoares@ctn.ist.utl.pt [Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS (Portugal); Araújo, M.F., E-mail: faraujo@ctn.ist.utl.pt [Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS (Portugal); Gonçalves, A.P., E-mail: apg@ctn.ist.utl.pt [Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela LRS (Portugal); Soares, R.M., E-mail: ruigusmao@hotmail.com [UNIARQ, Centro de Arqueologia da Universidade de Lisboa, Faculdade de Letras, Alameda da Universidade, 1600-214 Lisboa (Portugal)

    2015-09-01

    The Phoenician arrival at Iberian coastal regions had an actual influence on indigenous technology. A collection of coeval metallurgical remains and artefacts was studied by EDXRF, micro-EDXRF, SEM–EDS and XRD, to identify certain features of the production and utilisation of metal in protohistoric Western Iberia. The composition of artefacts indicates a prevalence of Cu–Sn alloys with low content of impurities (Pb, As, Sb and Fe) during Late Bronze and Early Iron Ages, while the composition of slags points to a smaller loss of copper in Phoenician smelting operations. Moreover, the amount of iron impurities in metal proved to be a helpful discriminator between indigenous and Phoenician-based metallurgies, showing that later alloys have higher amounts of iron. Besides, the indigenous alloys have higher tin contents that can probably be explained by the easier access to metal sources of local communities.

  11. Combining X-ray based methods to study the protohistoric bronze technology in Western Iberia

    International Nuclear Information System (INIS)

    Valério, P.; Silva, R.J.C.; Soares, A.M.M.; Araújo, M.F.; Gonçalves, A.P.; Soares, R.M.

    2015-01-01

    The Phoenician arrival at Iberian coastal regions had an actual influence on indigenous technology. A collection of coeval metallurgical remains and artefacts was studied by EDXRF, micro-EDXRF, SEM–EDS and XRD, to identify certain features of the production and utilisation of metal in protohistoric Western Iberia. The composition of artefacts indicates a prevalence of Cu–Sn alloys with low content of impurities (Pb, As, Sb and Fe) during Late Bronze and Early Iron Ages, while the composition of slags points to a smaller loss of copper in Phoenician smelting operations. Moreover, the amount of iron impurities in metal proved to be a helpful discriminator between indigenous and Phoenician-based metallurgies, showing that later alloys have higher amounts of iron. Besides, the indigenous alloys have higher tin contents that can probably be explained by the easier access to metal sources of local communities

  12. Teaching Professionals Environmental Management and Cleaner Technology Combining Educational Learning and Practice Learning

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik; Jørgensen, Michael Søgaard; Rasmussen, Bent Hesse

    2001-01-01

    -ordinating efficient management of environmental problems and technological processes of change in companies, and within the area of planning and co-ordinating relevant public regulation. Two of the major cornerstones in the education of Environmental Management are 1) the education should provide the students......The objective of the education of Environmental Manager is to make the student able to understand and co-ordinate solutions of environmental problems within the industrial sector and the public authorities. As such the education aims at qualifying the student both within the area of planning and co...... with new scientific theories and methods that relate to their field of practice. And 2) the education should bring in and develop new competencies and perspectives that can act as renewable elements in the students’ practical work. Among other things this means that the education becomes a place where...

  13. Process automation using combinations of process and machine control technologies with application to a continuous dissolver

    International Nuclear Information System (INIS)

    Spencer, B.B.; Yarbro, O.O.

    1991-01-01

    Operation of a continuous rotary dissolver, designed to leach uranium-plutonium fuel from chopped sections of reactor fuel cladding using nitric acid, has been automated. The dissolver is a partly continuous, partly batch process that interfaces at both ends with batchwise processes, thereby requiring synchronization of certain operations. Liquid acid is fed and flows through the dissolver continuously, whereas chopped fuel elements are fed to the dissolver in small batches and move through the compartments of the dissolver stagewise. Sequential logic (or machine control) techniques are used to control discrete activities such as the sequencing of isolation valves. Feedback control is used to control acid flowrates and temperatures. Expert systems technology is used for on-line material balances and diagnostics of process operation. 1 ref., 3 figs

  14. Combined mineralogical and EXAFS characterization of polluted sediments for the definition of technological variables and constraints

    Science.gov (United States)

    Brigatti, M. F.; Elmi, C.; Laurora, A.; Malferrari, D.; Medici, L.

    2009-04-01

    An extremely severe aspect, both from environmental and economic viewpoint, is the management of polluted sediments removed from drainage and irrigation canals. Canals, in order to retain their functionality over the time, need to have their beds, periodically cleaned from sediments there accumulating. The management of removed sediments is extremely demanding, also from an economical perspective, if these latter needs to be treated as dangerous waste materials, as stated in numerous international standards. Furthermore the disposal of such a large amount of material may introduce a significant environmental impact as well. An appealing alternative is the recovery or reuse of these materials, for example in brick and tile industry, after obviously the application of appropriate techniques and protocols that could render these latter no longer a threat for human health. The assessment of the effective potential danger for human health and ecosystem of sediments before and after treatment obviously requires both a careful chemical and mineralogical characterization and, even if not always considered in the international standards, the definition of the coordination shell of heavy metals dangerous for human health, as a function of their oxidation state and coordination (e.g. Cr and Pb), and introducing technological constraints or affecting the features of the end products. Fe is a good representative for this second category, as the features of the end product, such as color, strongly depend not only from Fe concentration but also from its oxidation state, speciation and coordination. This work will first of all provide mineralogical characterization of sediments from various sampling points of irrigation and drainage canals of Po river region in the north-eastern of Italy. Samples were investigated with various approaches including X-ray powder diffraction under non-ambient conditions, thermal analysis and EXAFS spectroscopy. Obtained results, and in particular

  15. Combining Google Earth and GIS mapping technologies in a dengue surveillance system for developing countries

    Directory of Open Access Journals (Sweden)

    Sobieszczyk Magdalena E

    2009-07-01

    Full Text Available Abstract Background Dengue fever is a mosquito-borne illness that places significant burden on tropical developing countries with unplanned urbanization. A surveillance system using Google Earth and GIS mapping technologies was developed in Nicaragua as a management tool. Methods and Results Satellite imagery of the town of Bluefields, Nicaragua captured from Google Earth was used to create a base-map in ArcGIS 9. Indices of larval infestation, locations of tire dumps, cemeteries, large areas of standing water, etc. that may act as larval development sites, and locations of the homes of dengue cases collected during routine epidemiologic surveying were overlaid onto this map. Visual imagery of the location of dengue cases, larval infestation, and locations of potential larval development sites were used by dengue control specialists to prioritize specific neighborhoods for targeted control interventions. Conclusion This dengue surveillance program allows public health workers in resource-limited settings to accurately identify areas with high indices of mosquito infestation and interpret the spatial relationship of these areas with potential larval development sites such as garbage piles and large pools of standing water. As a result, it is possible to prioritize control strategies and to target interventions to highest risk areas in order to eliminate the likely origin of the mosquito vector. This program is well-suited for resource-limited settings since it utilizes readily available technologies that do not rely on Internet access for daily use and can easily be implemented in many developing countries for very little cost.

  16. Effect of molecular weight and ratio of poly ethylene glycols' derivatives in combination with trehalose on stability of freeze-dried IgG.

    Science.gov (United States)

    Mohammad Zadeh, Amir Hossein; Rouholamini Najafabadi, Abdolhosein; Vatanara, Alireza; Faghihi, Homa; Gilani, Kambiz

    2017-12-01

    The influence of poly ethylene glycol (PEG) at different molecular weights (MWs) and ratios was studied on the stability of freeze-dried immune globulin G (IgG). PEGs (600-4000 Dalton) at concentrations of 0.5 and 5% W/V were applied in the presence of 40 and 60% W/W of trehalose to prepare freeze-dried IgG formulations. Size-exclusion chromatography, infra-red spectroscopy, differential scanning calorimeter, and gel electrophoresis were performed to characterize lyophilized samples. Pure IgG demonstrated the highest aggregation of 5.77 ± 0.10% after process and 12.66 ± 0.50% as well as 44.69 ± 0.50% upon 1 and 2 months of storage at 45 °C, respectively. 5% W/V of PEGs 4000 in combination with 40% W/W trehalose, significantly suppressed aggregation, 0.05 ± 0.01%, with minimum aggregation rate constant of 0.32 (1/month). The integrity of IgG molecules and secondary conformation were properly preserved in all formulations comparing native IgG. It could be concluded that appropriate concentration and MW of PEGs, prominently augmented stabilizing effect of trehalose on freeze-dried antibody through inserting additional supportive mechanisms of actions.

  17. Synergistic effects from graphene and carbon nanotubes endow ordered hierarchical structure foams with a combination of compressibility, super-elasticity and stability and potential application as pressure sensors.

    Science.gov (United States)

    Kuang, Jun; Dai, Zhaohe; Liu, Luqi; Yang, Zhou; Jin, Ming; Zhang, Zhong

    2015-01-01

    Nanostructured carbon material based three-dimensional porous architectures have been increasingly developed for various applications, e.g. sensors, elastomer conductors, and energy storage devices. Maintaining architectures with good mechanical performance, including elasticity, load-bearing capacity, fatigue resistance and mechanical stability, is prerequisite for realizing these functions. Though graphene and CNT offer opportunities as nanoscale building blocks, it still remains a great challenge to achieve good mechanical performance in their microarchitectures because of the need to precisely control the structure at different scales. Herein, we fabricate a hierarchical honeycomb-like structured hybrid foam based on both graphene and CNT. The resulting materials possess excellent properties of combined high specific strength, elasticity and mechanical stability, which cannot be achieved in neat CNT and graphene foams. The improved mechanical properties are attributed to the synergistic-effect-induced highly organized, multi-scaled hierarchical architectures. Moreover, with their excellent electrical conductivity, we demonstrated that the hybrid foams could be used as pressure sensors in the fields related to artificial skin.

  18. Crack stability in a representative piping system under combined inertial and seismic/dynamic displacement-controlled stresses. Subtask 1.3 final report

    International Nuclear Information System (INIS)

    Scott, P.; Olson, R.; Wilkowski, O.G.; Marschall, C.; Schmidt, R.

    1997-06-01

    This report presents the results from Subtask 1.3 of the International Piping Integrity Research Group (IPIRG) program. The objective of Subtask 1.3 is to develop data to assess analysis methodologies for characterizing the fracture behavior of circumferentially cracked pipe in a representative piping system under combined inertial and displacement-controlled stresses. A unique experimental facility was designed and constructed. The piping system evaluated is an expansion loop with over 30 meters of 16-inch diameter Schedule 100 pipe. The experimental facility is equipped with special hardware to ensure system boundary conditions could be appropriately modeled. The test matrix involved one uncracked and five cracked dynamic pipe-system experiments. The uncracked experiment was conducted to evaluate piping system damping and natural frequency characteristics. The cracked-pipe experiments evaluated the fracture behavior, pipe system response, and stability characteristics of five different materials. All cracked-pipe experiments were conducted at PWR conditions. Material characterization efforts provided tensile and fracture toughness properties of the different pipe materials at various strain rates and temperatures. Results from all pipe-system experiments and material characterization efforts are presented. Results of fracture mechanics analyses, dynamic finite element stress analyses, and stability analyses are presented and compared with experimental results

  19. Crack stability in a representative piping system under combined inertial and seismic/dynamic displacement-controlled stresses. Subtask 1.3 final report

    Energy Technology Data Exchange (ETDEWEB)

    Scott, P.; Olson, R.; Wilkowski, O.G.; Marschall, C.; Schmidt, R.

    1997-06-01

    This report presents the results from Subtask 1.3 of the International Piping Integrity Research Group (IPIRG) program. The objective of Subtask 1.3 is to develop data to assess analysis methodologies for characterizing the fracture behavior of circumferentially cracked pipe in a representative piping system under combined inertial and displacement-controlled stresses. A unique experimental facility was designed and constructed. The piping system evaluated is an expansion loop with over 30 meters of 16-inch diameter Schedule 100 pipe. The experimental facility is equipped with special hardware to ensure system boundary conditions could be appropriately modeled. The test matrix involved one uncracked and five cracked dynamic pipe-system experiments. The uncracked experiment was conducted to evaluate piping system damping and natural frequency characteristics. The cracked-pipe experiments evaluated the fracture behavior, pipe system response, and stability characteristics of five different materials. All cracked-pipe experiments were conducted at PWR conditions. Material characterization efforts provided tensile and fracture toughness properties of the different pipe materials at various strain rates and temperatures. Results from all pipe-system experiments and material characterization efforts are presented. Results of fracture mechanics analyses, dynamic finite element stress analyses, and stability analyses are presented and compared with experimental results.

  20. Heart failure analysis dashboard for patient's remote monitoring combining multiple artificial intelligence technologies.

    Science.gov (United States)

    Guidi, G; Pettenati, M C; Miniati, R; Iadanza, E

    2012-01-01

    In this paper we describe an Heart Failure analysis Dashboard that, combined with a handy device for the automatic acquisition of a set of patient's clinical parameters, allows to support telemonitoring functions. The Dashboard's intelligent core is a Computer Decision Support System designed to assist the clinical decision of non-specialist caring personnel, and it is based on three functional parts: Diagnosis, Prognosis, and Follow-up management. Four Artificial Intelligence-based techniques are compared for providing diagnosis function: a Neural Network, a Support Vector Machine, a Classification Tree and a Fuzzy Expert System whose rules are produced by a Genetic Algorithm. State of the art algorithms are used to support a score-based prognosis function. The patient's Follow-up is used to refine the diagnosis.

  1. Combination of existing and alternative technologies to promote oilseeds and pulses proteins in food applications

    Directory of Open Access Journals (Sweden)

    Chéreau Denis

    2016-07-01

    Full Text Available The continuous world population growth induces a total protein demand increase based mainly on plant sources. To meet these global nutritional challenges, existing and innovative dry and wet fractionation processes will have to be combined to better valorise plant protein fraction from pulses and oilseeds. The worldwide success of soy protein isolates originate from the intrinsic qualities of soybean proteins but also from a continuous R&D effort since mid-twenty century. Therefore, the soy protein development model can be applied to protein isolates from diverse pulses and oilseeds meals as rapeseed which has already been recognised as novel food protein in Europe. To boost the delivery of plant proteins, agrofood-industries and academics must pool their respective expertise. Innovative and issue solving R&D projects have to be launched to better valorise pulses and oilseed proteins by (i creating oil extraction processes which preserve native proteins structure; (ii developing novel protein extraction processes from lab up to industrial pilot scale; (iii producing plant protein isolates having comparable foaming, emulsifying or gelling functionality than animal; and (iv generating hydrolysed proteins with high digestibility adapted to human nutrition. It is also essential to initiate research programs to innovate in wet and dry fractionations of plants or to design in vitro models to evaluate proteins digestibility and allergenicity. The increased awareness regarding plant protein valorisation resulted in the creation by agro-industries and academics of the open platform IMPROVE which propose a combination of competencies and equipment to boost market uptake of Plant Based Proteins.

  2. Thermal stabilization of bicelles by a bile-salt-derived detergent: a combined ³¹P and ²H nuclear magnetic resonance study.

    Science.gov (United States)

    Morales, Hannah Hazel; Saleem, Qasim; Macdonald, Peter M

    2014-12-23

    The properties of bicelles composed of mixtures of long-chain lipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG), stabilized by zwitterionic bile salt analogue 3-[(3-cholamidopropyl)dimethyl-d6-ammonio]-2-hydroxy-1-propanesulfonate (CHAPSO-d6), deuterated at both amino methyls, were investigated by a combination of (31)P and (2)H NMR, focusing on the behavior of CHAPSO as a function of temperature. For compositions of molar ratio q = [DMPC + DMPG]/[CHAPSO] = 3, R = [DMPG]/[DMPC + DMPG] = 0, 0.01 and 0.10 and lipid concentration CL = 25 wt % lipid at temperatures of between 30 and 60 °C, magnetic alignment was readily achieved as assessed via both (31)P NMR of the phospholipids and (2)H NMR of CHAPSO-d6. Increasing temperature yielded higher values for the chemical shift anisotropy of the former and the quadrupole splitting of the latter, consistent with the progressive migration of CHAPSO from edge regions into planar regions of the bicellar assemblies. However, relative to dihexadecyl phosphatidylcholine (DHPC), CHAPSO exhibited lower miscibility with DMPC, although the presence of DMPG enhanced this miscibility. At 65 °C, thermal instability became evident in the appearance of a separate isotropic component in both (31)P and (2)H NMR spectra. This isotropic phase was CHAPSO-enriched but less so as a function of increasing DMPG. These findings indicate that the enhanced thermal stability of CHAPSO- versus DHPC-containing bicelles arises from a combination of the larger surface area that edge CHAPSO is able to mask, mole for mole, and its relative preference for edge regions, plus, possibly, specific interactions with DMPG.

  3. Using Bitmap Indexing Technology for Combined Numerical and TextQueries

    Energy Technology Data Exchange (ETDEWEB)

    Stockinger, Kurt; Cieslewicz, John; Wu, Kesheng; Rotem, Doron; Shoshani, Arie

    2006-10-16

    In this paper, we describe a strategy of using compressedbitmap indices to speed up queries on both numerical data and textdocuments. By using an efficient compression algorithm, these compressedbitmap indices are compact even for indices with millions of distinctterms. Moreover, bitmap indices can be used very efficiently to answerBoolean queries over text documents involving multiple query terms.Existing inverted indices for text searches are usually inefficient forcorpora with a very large number of terms as well as for queriesinvolving a large number of hits. We demonstrate that our compressedbitmap index technology overcomes both of those short-comings. In aperformance comparison against a commonly used database system, ourindices answer queries 30 times faster on average. To provide full SQLsupport, we integrated our indexing software, called FastBit, withMonetDB. The integrated system MonetDB/FastBit provides not onlyefficient searches on a single table as FastBit does, but also answersjoin queries efficiently. Furthermore, MonetDB/FastBit also provides avery efficient retrieval mechanism of result records.

  4. Opportunist combination of electronic technologies for real time calculations in the Tore Supra Tokamak

    International Nuclear Information System (INIS)

    Barbuti, A.; Gil, C.; Pastor, P.; Spuig, P.; Vincent, B.; Volpe, D.

    2013-06-01

    The Tore Supra tokamak real-time plasma control is based on measurements coming from various diagnostics. The complexity of all the events that occur during plasma is at the origin of measurements disturbances which have to be corrected in real time in order to ensure an optimal control. The signal correction does not just mean processing but requires complex algorithms. Electronics does not only need to process and adapt electrical signals, but it has to include corrections by mathematical calculation. The FPGA (field-programmable gate array) technology, with the help of basic adapted electronics, allows integrating the entire real time calculation and digital data transmission on the network. FMC (FPGA Mezzanine Card) coupled with in-house motherboard, which is used both as the interface with Tore Supra specific systems and as the support for other signals processing options, is the perfect answer to this request. The FMC includes a FPGA, memory, Ethernet port and multiple I/O for interfacing with the motherboard and Tore Supra signals. The algorithms are developed in VHDL (Very high speed integrated circuit Hardware Description Language), parallel process management that promotes faster calculation than a common μC (Micro-controller) in one clock pulse. The flexibility, the low cost and the implementation speed allow fitting a large number of various applications in fields where no 'off-theshelf' component can be found. And more specifically, in research and experimentation, algorithms can be continuously improved or modified for new requirements. (authors)

  5. Combining semantic technologies with a content-based image retrieval system - Preliminary considerations

    Science.gov (United States)

    Chmiel, P.; Ganzha, M.; Jaworska, T.; Paprzycki, M.

    2017-10-01

    Nowadays, as a part of systematic growth of volume, and variety, of information that can be found on the Internet, we observe also dramatic increase in sizes of available image collections. There are many ways to help users browsing / selecting images of interest. One of popular approaches are Content-Based Image Retrieval (CBIR) systems, which allow users to search for images that match their interests, expressed in the form of images (query by example). However, we believe that image search and retrieval could take advantage of semantic technologies. We have decided to test this hypothesis. Specifically, on the basis of knowledge captured in the CBIR, we have developed a domain ontology of residential real estate (detached houses, in particular). This allows us to semantically represent each image (and its constitutive architectural elements) represented within the CBIR. The proposed ontology was extended to capture not only the elements resulting from image segmentation, but also "spatial relations" between them. As a result, a new approach to querying the image database (semantic querying) has materialized, thus extending capabilities of the developed system.

  6. Liquigroud technique: a new concept for enhancing dissolution rate of glibenclamide by combination of liquisolid and co-grinding technologies.

    Science.gov (United States)

    Azharshekoufeh, Leila; Shokri, Javad; Barzegar-Jalali, Mohammad; Javadzadeh, Yousef

    2017-01-01

    Introduction: The potential of combining liquisolid and co-grinding technologies (liquiground technique) was investigated to improve the dissolution rate of a water-insoluble agent (glibenclamide) with formulation-dependent bioavailability. Methods: To this end, different formulations of liquisolid tablets with a wide variety of non-volatile solvents contained varied ratios of drug: solvent and dissimilar carriers were prepared, and then their release profiles were evaluated. Furthermore, the effect of size reduction by ball milling on the dissolution behavior of glibenclamide from liquisolid tablets was investigated. Any interaction between the drug and the excipient or crystallinity changes during formulation procedure was also examined using X-ray diffraction (XRD) and differential scanning calorimetry (DSC). Results: The present study revealed that classic liquisolid technique did not significantly affect the drug dissolution profile as compared to the conventional tablets. Size reduction obtained by co-grinding of liquid medication was more effective than the implementation of liquisolid technique in enhancing the dissolution rate of glibenclamide. The XRD and DSC data displayed no formation of complex or any crystallinity changes in both formulations. Conclusion: An enhanced dissolution rate of glibenclamide is achievable through the combination of liquisolid and co-grinding technologies.

  7. The Effects of Double Oscillation Exercise Combined with Elastic Band Exercise on Scapular Stabilizing Muscle Strength and Thickness in Healthy Young Individuals: A Randomized Controlled Pilot Trial

    Directory of Open Access Journals (Sweden)

    Jieun Cho, Kyeongbong Lee, Minkyu Kim, Joohee Hahn, Wanhee Lee

    2018-03-01

    Full Text Available This study aimed to investigate the effect of double oscillation exercise combined with elastic band exercise on the strength and thickness ratio of the scapular stabilizing muscles in healthy young individuals. A total of 30 subjects (17 male, 13 female were randomly assigned to an elastic band exercise group (EBG (n = 15 or an elastic band plus double oscillation exercise group (EB-DOG (n = 15. A total of 28 subjects completed the experiment and evaluation. Patients in the EBG performed the elastic band exercise for shoulder flexion, extension, abduction, adduction, horizontal abduction/adduction, and internal/external rotation for 30 minutes/session, five times/week, for four weeks. Patients in the EB-DOG performed the elastic band exercise for 15 minutes and the double oscillation exercise in three planes of motion (frontal, sagittal, and transverse, using a Bodyblade® for 15 minutes/session, five times/week, for four weeks. Shoulder muscle strength was assessed using a manual muscle test device during maximal voluntary isometric contraction (MVIC, while the thicknesses of the scapular stabilizing muscles were assessed using rehabilitative ultrasound imaging both at rest and during MVIC. Both groups had significant effects on shoulder muscle strength, however, there was no significant difference between the two groups for change value of shoulder muscle strength (Bonferroni correction p < 0.005. Significant differences were observed in the group × time interactions for horizontal abduction, external rotation, and protraction. There was a statistically significant improvement in thickness ratio of LT and SA in the EB-DOG and no significant difference was founded in EBG (Bonferroni correction p < 0.006. In comparison between the two groups, EB-DOG showed a significant change in the thickness ratio of LT compared to EBG. In addition, significant differences were observed for the group × time interactions for the thickness ratio of the LT (F

  8. Characterization of aqueous two phase systems by combining lab-on-a-chip technology with robotic liquid handling stations.

    Science.gov (United States)

    Amrhein, Sven; Schwab, Marie-Luise; Hoffmann, Marc; Hubbuch, Jürgen

    2014-11-07

    Over the last decade, the use of design of experiment approaches in combination with fully automated high throughput (HTP) compatible screenings supported by robotic liquid handling stations (LHS), adequate fast analytics and data processing has been developed in the biopharmaceutical industry into a strategy of high throughput process development (HTPD) resulting in lower experimental effort, sample reduction and an overall higher degree of process optimization. Apart from HTP technologies, lab-on-a-chip technology has experienced an enormous growth in the last years and allows further reduction of sample consumption. A combination of LHS and lab-on-a-chip technology is highly desirable and realized in the present work to characterize aqueous two phase systems with respect to tie lines. In particular, a new high throughput compatible approach for the characterization of aqueous two phase systems regarding tie lines by exploiting differences in phase densities is presented. Densities were measured by a standalone micro fluidic liquid density sensor, which was integrated into a liquid handling station by means of a developed generic Tip2World interface. This combination of liquid handling stations and lab-on-a-chip technology enables fast, fully automated, and highly accurate density measurements. The presented approach was used to determine the phase diagram of ATPSs composed of potassium phosphate (pH 7) and polyethylene glycol (PEG) with a molecular weight of 300, 400, 600 and 1000 Da respectively in the presence and in the absence of 3% (w/w) sodium chloride. Considering the whole ATPS characterization process, two complete ATPSs could be characterized within 24h, including four runs per ATPS for binodal curve determination (less than 45 min/run), and tie line determination (less than 45 min/run for ATPS preparation and 8h for density determination), which can be performed fully automated over night without requiring man power. The presented methodology provides

  9. Refrigerated Fruit Storage Monitoring Combining Two Different Wireless Sensing Technologies: RFID and WSN

    Directory of Open Access Journals (Sweden)

    Ricardo Badia-Melis

    2015-02-01

    Full Text Available Every day, millions of tons of temperature-sensitive goods are produced, transported, stored or distributed worldwide, thus making their temperature and humidity control essential. Quality control and monitoring of goods during the cold chain is an increasing concern for producers, suppliers, logistic decision makers and consumers. In this paper we present the results of a combination of RFID and WSN devices in a set of studies performed in three commercial wholesale chambers of 1848 m3 with different set points and products. Up to 90 semi-passive RFID temperature loggers were installed simultaneously together with seven motes, during one week in each chamber. 3D temperature mapping charts were obtained and also the psychrometric data model from ASABE was implemented for the calculation of enthalpy changes and the absolute water content of air. Thus thank to the feedback of data, between RFID and WSN it is possible to estimate energy consumption in the cold room, water loss from the products and detect any condensation over the stored commodities.

  10. Rapid prototyping of multi-scale biomedical microdevices by combining additive manufacturing technologies.

    Science.gov (United States)

    Hengsbach, Stefan; Lantada, Andrés Díaz

    2014-08-01

    The possibility of designing and manufacturing biomedical microdevices with multiple length-scale geometries can help to promote special interactions both with their environment and with surrounding biological systems. These interactions aim to enhance biocompatibility and overall performance by using biomimetic approaches. In this paper, we present a design and manufacturing procedure for obtaining multi-scale biomedical microsystems based on the combination of two additive manufacturing processes: a conventional laser writer to manufacture the overall device structure, and a direct-laser writer based on two-photon polymerization to yield finer details. The process excels for its versatility, accuracy and manufacturing speed and allows for the manufacture of microsystems and implants with overall sizes up to several millimeters and with details down to sub-micrometric structures. As an application example we have focused on manufacturing a biomedical microsystem to analyze the impact of microtextured surfaces on cell motility. This process yielded a relevant increase in precision and manufacturing speed when compared with more conventional rapid prototyping procedures.

  11. Rocket-Based Combined Cycle Engine Technology Development: Inlet CFD Validation and Application

    Science.gov (United States)

    DeBonis, J. R.; Yungster, S.

    1996-01-01

    A CFD methodology has been developed for inlet analyses of Rocket-Based Combined Cycle (RBCC) Engines. A full Navier-Stokes analysis code, NPARC, was used in conjunction with pre- and post-processing tools to obtain a complete description of the flow field and integrated inlet performance. This methodology was developed and validated using results from a subscale test of the inlet to a RBCC 'Strut-Jet' engine performed in the NASA Lewis 1 x 1 ft. supersonic wind tunnel. Results obtained from this study include analyses at flight Mach numbers of 5 and 6 for super-critical operating conditions. These results showed excellent agreement with experimental data. The analysis tools were also used to obtain pre-test performance and operability predictions for the RBCC demonstrator engine planned for testing in the NASA Lewis Hypersonic Test Facility. This analysis calculated the baseline fuel-off internal force of the engine which is needed to determine the net thrust with fuel on.

  12. Study of a combined heterotrophic and sulfur autotrophic denitrification technology for removal of nitrate in water

    International Nuclear Information System (INIS)

    Liu Huijuan; Jiang Wei; Wan Dongjin; Qu Jiuhui

    2009-01-01

    A combined two-step process of heterotrophic denitrification in a fluidized reactor and sulfur autotrophic denitrification processes (CHSAD) was developed for the removal of nitrate in drinking water. In this process, the advantage of high efficiency of heterotrophic denitrification with non-excessive methanol and the advantage of non-pollution of sulfur autotriphic denitrification were integrated in this CHSAD process. And, this CHSAD process had the capacity of pH balance and could control the concentration of SO 4 2- in effluent by adjusting the operation condition. When the influent nitrate was 30 mg NO 3 - -N/L, the reactor could be operated efficiently at the hydraulic retention time (HRT) ranging from 20 to 40 min with C:N ratio (mg CH 3 OH:mg NO 3 - -N) of 2.0 (methanol as carbon source). The nitrate removal was nearly 100% and there was no accumulated nitrite or residual methanol in the effluent. The effluent pH was about 7.5 and the sulfate concentration was lower than 130 mg/L. The maximum volume-loading rate of the reactor was 2.16 kg NO 3 - -N/(m 3 d). The biomass and scanning electron microscopy graphs of biofilm were also analyzed.

  13. Teaching with technology: learning outcomes for a combined dental and dental hygiene online hybrid oral histology course.

    Science.gov (United States)

    Gadbury-Amyot, Cynthia C; Singh, Amul H; Overman, Pamela R

    2013-06-01

    Among the challenges leaders in dental and allied dental education have faced in recent years is a shortage of well-qualified faculty members, especially in some specialty areas of dentistry. One proposed solution has been the use of technology. At the University of Missouri-Kansas City School of Dentistry, the departure of a faculty member who taught the highly specialized content in oral histology and embryology provided the opportunity to implement distance delivery of that course. The course is taught once a year to a combined group of dental and dental hygiene students. Previous to spring semester of 2009, the course was taught using traditional face-to-face, in-class lectures and multiple-choice examinations. During the spring semesters of 2009, 2010, and 2011, the course was taught using synchronous and asynchronous distance delivery technology. Outcomes for these courses (including course grades and performance on the National Board Dental Examination Part I) were compared to those from the 2006, 2007, and 2008 courses. Students participating in the online hybrid course were also given an author-designed survey, and the perceptions of the faculty member who made the transition from teaching the course in a traditional face-to-face format to teaching in an online hybrid format were solicited. Overall, student and faculty perceptions and student outcomes and course reviews have been positive. The results of this study can provide guidance to those seeking to use technology as one method of curricular delivery.

  14. Storytelling and Technology Combine to Create Student Engagement Around Locally Relevant Climate Change Topics.

    Science.gov (United States)

    Leckey, E.; Littrell-Baez, M.; Tayne, K.; Gold, A. U.; Okochi, C.; Oonk, D.; Smith, L. K.; Lynds, S. E.

    2017-12-01

    films. We suggest that the combination of storytelling and filmmaking gives students a means to become part of the climate change narrative and to engage in thinking about and acting on climate change at a broader level than they might otherwise be comfortable doing.

  15. Development of safe juices for immunocompromised patients by irradiation alone or in combination with other technologies

    International Nuclear Information System (INIS)

    Abd El-kader, R.M.M.

    2012-01-01

    Gy in combination with cinnamaldehyde (8μl/100 ml) greatly reduced the microbial load of carrot juice and extended its shelf-life to 21 days at 4°C±1 without adverse effect on the sensory and nutritional quality

  16. Wood-derived-biochar combined with compost or iron grit for in situ stabilization of Cd, Pb, and Zn in a contaminated soil.

    Science.gov (United States)

    Oustriere, Nadège; Marchand, Lilian; Rosette, Gabriel; Friesl-Hanl, Wolfgang; Mench, Michel

    2017-03-01

    In situ stabilization of Cd, Pb, and Zn in an Austrian agricultural soil contaminated by atmospheric depositions from a smelter plant was assessed with a pine bark chip-derived biochar, alone and in combination with either compost or iron grit. Biochar amendment was also trialed in an uncontaminated soil to detect any detrimental effect. The pot experiment consisted in ten soil treatments (% w/w): untreated contaminated soil (Unt); Unt soil amended with biochar alone (1%: B1; 2.5%: B2.5) and in combination: B1 and B2.5 + 5% compost (B1C and B2.5C), B1 and B2.5 + 1% iron grit (B1Z and B2.5Z); uncontaminated soil (Ctrl); Ctrl soil amended with 1 or 2.5% biochar (CtrlB1, CtrlB2.5). After a 3-month reaction period, the soil pore water (SPW) was sampled in potted soils and dwarf beans were grown for a 2-week period. The SPW Cd, Pb, and Zn concentrations decreased in all amended-contaminated soils. The biochar effects increased with its addition rate and its combination with either compost or iron grit. Shoot Cd and Zn removals by beans were reduced and shoot Cd, Pb, and Zn concentrations decreased to common values in all amended soils except the B1 soil. Decreases in the SPW Cd/Pb/Zn concentrations did not improve the root and shoot yields of plants as compared to the Ctrl soil.

  17. α- and β-Carotene Stability During Storage of Microspheres Obtained from Spray-Dried Microencapsulation Technology

    Directory of Open Access Journals (Sweden)

    Przybysz Marzena Anna

    2018-03-01

    Full Text Available This study was aimed at comparing the stability of carotenes (α- and β-carotene in oil solutions with their stability when spray-dried encapsulation is applied. The carotenes were isolated from carrot. A storage test was subsequently performed. The stability of carotenes in oil solutions was determined with the HPLC method. The color of the samples was also analyzed. The oil solutions of carotenes were microencapsulated with the spray-drying method. A mixture of gum Arabic and maltodextrin was used as a matrix.

  18. A microencapsulation process of liquid mercury by sulfur polymer stabilization/solidification technology. Part II: Durability of materials

    Directory of Open Access Journals (Sweden)

    López-Delgado, A.

    2012-02-01

    Full Text Available Under the European LIFE Program a microencapsulation process was developed for liquid mercury using Sulfur Polymer Stabilization/Solidification (SPSS technology, obtaining a stable concrete-like sulfur matrix that allows the immobilization of mercury for long-term storage. The process description and characterization of the materials obtained were detailed in Part I. The present document, Part II, reports the results of different tests carried out to determine the durability of Hg-S concrete samples with very high mercury content (up to 30 % w/w. Different UNE and RILEM standard test methods were applied, such as capillary water absorption, low pressure water permeability, alkali/acid resistance, salt mist aging, freeze-thaw resistance and fire performance. The samples exhibited no capillarity and their resistance in both alkaline and acid media was very high. They also showed good resistance to very aggressive environments such as spray salt mist, freeze-thaw and dry-wet. The fire hazard of samples at low heat output was negligible.

    Dentro del Programa Europeo LIFE, se ha desarrollado un proceso de microencapsulación de mercurio liquido, utilizando la tecnología de estabilización/solidificación con azufre polimérico (SPSS. Como resultado se ha obtenido un material estable tipo concreto que permite la inmovilización de mercurio y su almacenamiento a largo plazo. La descripción del proceso y la caracterización de los materiales obtenidos, denominados concretos Hg-S, se detallan en la Parte I. El presente trabajo, Parte II, incluye los resultados de los diferentes ensayos realizados para determinar la durabilidad de las muestras de concreto Hg-S con un contenido de mercurio de hasta el 30 %. Se han utilizado diferentes métodos de ensayo estándar, UNE y RILEM, para determinar propiedades como la absorción de agua por capilaridad, la permeabilidad de agua a baja presión, la resistencia a álcali y ácido, el comportamiento en

  19. Combined electrolysis and catalytic exchange (CECE) technology - an economical alternative for heavy water upgraders using water distillation

    International Nuclear Information System (INIS)

    Ryland, D.K.; Sadhankar, R.R.

    2003-01-01

    Heavy water upgrading is a unique and crucial part of a CANDU power station. Water distillation (DW) systems are used for heavy water upgrading in all CANDU stations. The DW upgrader is designed to take advantage of the difference in relative volatility (a measure of separation of isotopes) between H 2 O and D 2 O. However, the low relative volatility of the H 2 O/D 2 O system requires large number of stages (long columns) and large reflux ratios (large reboiler loads) - thus resulting in significant capital and operating costs. Atomic Energy of Canada Limited (AECL) developed the Combined Electrolysis and Catalytic Exchange (CECE) technology as an economical alternative to the DW system. CECE-based upgraders have been demonstrated in pilot scale facilities at AECL Chalk River Laboratories and in Hamilton, Ontario. This design is based on catalytic hydrogen isotope exchange between water and hydrogen gas. (author)

  20. Sustainability assessment of one industrial region: A combined method of emergy analysis and IPAT (Human Impact Population Affluence Technology)

    International Nuclear Information System (INIS)

    Yu, Xiaoman; Geng, Yong; Dong, Huijuan; Ulgiati, Sergio; Liu, Zhe; Liu, Zuoxi; Ma, Zhixiao; Tian, Xu; Sun, Lu

    2016-01-01

    Resource over-exploitation and resource depletion have received increasing attentions, especially for industrial regions. In this paper an innovative method that combines emergy analysis and an IPAT (Human Impact Population Affluence Technology) equation is developed in order to create an integrated framework for uncovering the driving forces on resource consumption in one industrial region. Liaoning province, one of the old heavy industrial bases in China, is selected as the case study region. The main results show that total emergy of Liaoning province increased from 9.25E + 23 sej in 2002 to 1.92E + 24 sej in 2012, with 165% growth on non-renewable emergy and 250% growth on imported emergy. Regional emergy/RMB ratio was higher than other developed regions and the average value of China, indicating that this province consumed more local free non-renewable resources to support its own development. The lower ESI (emergy sustainability index) indicates that Liaoning province's sustainability is still weak and far away from sustainable development. IPAT analysis further identifies that rapid economic growth was the main driving force to increase its total emergy use, while technology innovation offset the increase of total emergy use. Policy insights suggest that industrial regions should improve their energy efficiency and optimize their economic and energy structure by applying economic instruments and capacity building efforts. - Highlights: • Emergy analysis and IPAT are combined to evaluate the sustainability of Liaoning. • Total emergy of Liaoning increased from 2002 to 2011 and then decreased in 2012. • Economic scale is the key driving force to induce higher emergy consumption. • Valuable policy insights are proposed in order to promote sustainable development.

  1. Combining two technologies: multifunctional polymers and self-nanoemulsifying drug delivery system (SNEDDS) for oral insulin administration.

    Science.gov (United States)

    Sakloetsakun, Duangkamon; Dünnhaupt, Sarah; Barthelmes, Jan; Perera, Glen; Bernkop-Schnürch, Andreas

    2013-10-01

    The aim of the study is to develop a self-nanoemulsifying drug delivery system (SNEDDS) based on thiolated chitosan for oral insulin administration. The preparations were characterized by particle size, entrapment efficiency, stability and drug release. Serum insulin concentrations were determined after oral administration of all formulations. Insulin SNEDDS formulation was served as control. The optimized SNEDDS consists of 65% (w/w) miglyol 840, 25% (w/w) cremophor EL, 10% (w/w) co-solvents (a mixture of DMSO and glycerol). The formulations in the presence or absence of insulin (5mg/mL) were spherical with the size range between 80 and 160 nm. Entrapment efficiency of insulin increased significantly when the thiolated chitosan was employed (95.14±2.96%), in comparison to the insulin SNEDDS (80.38±1.22%). After 30 min, the in vitro release profile of insulin from the nanoemulsions was markedly increased compared to the control. In vivo results showed that insulin/thiolated chitosan SNEDDS displayed a significant increase in serum insulin (p-value=0.02) compared to oral insulin solution. A new strategy to combine SNEDDS and thiolated chitosan described in the study would therefore be a promising and innovative approach to improve oral bioavailability of insulin. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

  2. A methodological combined framework for roadmapping biosensor research: a fault tree analysis approach within a strategic technology evaluation frame.

    Science.gov (United States)

    Siontorou, Christina G; Batzias, Fragiskos A

    2014-03-01

    Biosensor technology began in the 1960s to revolutionize instrumentation and measurement. Despite the glucose sensor market success that revolutionized medical diagnostics, and artificial pancreas promise currently the approval stage, the industry is reluctant to capitalize on other relevant university-produced knowledge and innovation. On the other hand, the scientific literature is extensive and persisting, while the number of university-hosted biosensor groups is growing. Considering the limited marketability of biosensors compared to the available research output, the biosensor field has been used by the present authors as a suitable paradigm for developing a methodological combined framework for "roadmapping" university research output in this discipline. This framework adopts the basic principles of the Analytic Hierarchy Process (AHP), replacing the lower level of technology alternatives with internal barriers (drawbacks, limitations, disadvantages), modeled through fault tree analysis (FTA) relying on fuzzy reasoning to count for uncertainty. The proposed methodology is validated retrospectively using ion selective field effect transistor (ISFET) - based biosensors as a case example, and then implemented prospectively membrane biosensors, putting an emphasis on the manufacturability issues. The analysis performed the trajectory of membrane platforms differently than the available market roadmaps that, considering the vast industrial experience in tailoring and handling crystallic forms, suggest the technology path of biomimetic and synthetic materials. The results presented herein indicate that future trajectories lie along with nanotechnology, and especially nanofabrication and nano-bioinformatics, and focused, more on the science-path, that is, on controlling the natural process of self-assembly and the thermodynamics of bioelement-lipid interaction. This retained the nature-derived sensitivity of the biosensor platform, pointing out the differences

  3. Subcritical water extraction combined with molecular imprinting technology for sample preparation in the detection of triazine herbicides.

    Science.gov (United States)

    Zhao, Fengnian; Wang, Shanshan; She, Yongxin; Zhang, Chao; Zheng, Lufei; Jin, Maojun; Shao, Hua; Jin, Fen; Du, Xinwei; Wang, Jing

    2017-09-15

    A selective, environmentally friendly, and cost-effective sample extraction method based on a combination of subcritical water extraction (SWE) and molecularly imprinted solid-phase extraction (MISPE) was developed for the determination of eight triazine herbicides in soil samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS). In SWE, the highest extraction yields of triazine herbicides were obtained under 150°C for 15min using 20% ethanol as the organic modifier. Addition of MIP during SWE increased the extraction efficiency, and using MIP as a selective SPE sorbent improved the enrichment capability. Soil samples were treated with the optimized extraction MIP/SWE-MISPE method and analyzed by LC-MS/MS. The novel technique was then applied to soil samples for the determination of triazine herbicides, and better recoveries (78.9%-101%) were obtained compared with using SWE-MISPE (30%-67%). Moreover, this newly developed method displayed good linearity (R 2 >0.99) and precision (2.7-9.8%), and low enough detection limits (0.4-3.3μgkg -1 ). This combination of SWE and MIP technology is a simple, effective and promising method to selectively extract class-specific compounds in complex samples. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Combination of elastography and tissue quantification using the acoustic radiation force impulse (ARFI) technology for differential diagnosis of breast masses.

    Science.gov (United States)

    Tozaki, Mitsuhiro; Isobe, Sachiko; Sakamoto, Masaaki

    2012-10-01

    We evaluated the diagnostic performance of elastography and tissue quantification using acoustic radiation force impulse (ARFI) technology for differential diagnosis of breast masses. There were 161 mass lesions. First, lesion correspondence on ARFI elastographic images to those on the B-mode images was evaluated: no findings on ARFI images (pattern 1), lesions that were bright inside (pattern 2), lesions that were dark inside (pattern 4), lesions that contained both bright and dark areas (pattern 3). In addition, pattern 4 was subdivided into 4a (dark area same as B-mode lesion) and 4b (dark area larger than lesion). Next, shear wave velocity (SWV) was measured using virtual touch tissue quantification. There were 13 pattern 1 lesions and five pattern 2 lesions; all of these lesions were benign, whereas all pattern 4b lesions (n = 43) were malignant. When the value of 3.59 m/s was chosen as the cutoff value, the combination of elastography and tissue quantification showed 91 % (83-91) sensitivity, 93 % (65-70) specificity, and 92 % (148-161) accuracy. The combination of elastography and tissue quantification is thought to be a promising ultrasound technique for differential diagnosis of breast-mass lesions.

  5. Application of quality by design concept to develop a dual gradient elution stability-indicating method for cloxacillin forced degradation studies using combined mixture-process variable models.

    Science.gov (United States)

    Zhang, Xia; Hu, Changqin

    2017-09-08

    Penicillins are typical of complex ionic samples which likely contain large number of degradation-related impurities (DRIs) with different polarities and charge properties. It is often a challenge to develop selective and robust high performance liquid chromatography (HPLC) methods for the efficient separation of all DRIs. In this study, an analytical quality by design (AQbD) approach was proposed for stability-indicating method development of cloxacillin. The structures, retention and UV characteristics rules of penicillins and their impurities were summarized and served as useful prior knowledge. Through quality risk assessment and screen design, 3 critical process parameters (CPPs) were defined, including 2 mixture variables (MVs) and 1 process variable (PV). A combined mixture-process variable (MPV) design was conducted to evaluate the 3 CPPs simultaneously and a response surface methodology (RSM) was used to achieve the optimal experiment parameters. A dual gradient elution was performed to change buffer pH, mobile-phase type and strength simultaneously. The design spaces (DSs) was evaluated using Monte Carlo simulation to give their possibility of meeting the specifications of CQAs. A Plackett-Burman design was performed to test the robustness around the working points and to decide the normal operating ranges (NORs). Finally, validation was performed following International Conference on Harmonisation (ICH) guidelines. To our knowledge, this is the first study of using MPV design and dual gradient elution to develop HPLC methods and improve separations for complex ionic samples. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Physicochemical characterization and oxidative stability of fish oil-loaded electrosprayed capsules: Combined use of whey protein and carbohydrates as wall materials

    DEFF Research Database (Denmark)

    García Moreno, Pedro Jesús; Pelayo, Andres; Yu, Sen

    2018-01-01

    The encapsulation of fish oil in electrosprayed capsules using whey protein and carbohydrates (pullulan and dextran or glucose syrup) mixtures as glassy wall materials was studied. Capsules with fish oil emulsified by using only a rotor-stator emulsification exhibited higher oxidative stability...... than capsules where the oil was emulsified by high-pressure homogenization. Moreover, glucose syrup capsules (with a peroxide value, PV, of 19.7 ± 4.4 meq/kg oil and a content of 1-penten-3-ol of 751.0 ± 69.8 ng/g oil) were less oxidized than dextran capsules after 21 days of storage at 20 °C (PV of 24.......9 ± 0.4 meq/kg oil and 1-penten-3-ol of 1161.0 ± 222.0 ng/g oil). This finding may be attributed to differences in oxygen permeability between both types of capsules. These results indicated the potential of both combinations of whey protein, pullulan, and dextran or glucose syrup as shell materials...

  7. Development and Validation of a Stability-Indicating HPLC Method for the Simultaneous Determination of Florfenicol and Flunixin Meglumine Combination in an Injectable Solution

    Directory of Open Access Journals (Sweden)

    Nidal Batrawi

    2017-01-01

    Full Text Available The combination of the powerful antimicrobial agent florfenicol and the nonsteroidal anti-inflammatory flunixin meglumine is used for the treatment of bovine respiratory disease (BRD and control of BRD-associated pyrexia, in beef and nonlactating dairy cattle. This study describes the development and validation of an HPLC-UV method for the simultaneous determination of florfenicol and flunixin, in an injectable preparation with a mixture of excipients. The proposed RP-HPLC method was developed by a reversed phase- (RP- C18e (250 mm × 4.6 mm, 5 μm column at room temperature, with an isocratic mobile phase of acetonitrile and water mixture, and pH was adjusted to 2.8 using diluted phosphoric acid, a flow rate of 1.0 mL/min, and ultraviolet detection at 268 nm. The stability-indicating method was developed by exposing the drugs to stress conditions of acid and base hydrolysis, oxidation, photodegradation, and thermal degradation; the obtained degraded products were successfully separated from the APIs. This method was validated in accordance with FDA and ICH guidelines and showed excellent linearity, accuracy, precision, specificity, robustness, LOD, LOQ, and system suitability results within the acceptance criteria.

  8. Stress degradation studies and development of stability-indicating TLC-densitometry method for determination of prednisolone acetate and chloramphenicol in their individual and combined pharmaceutical formulations

    Directory of Open Access Journals (Sweden)

    Musharraf Syed

    2012-01-01

    Full Text Available Abstract A rapid and reproducible stability indicating TLC method was developed for the determination of prednisolone acetate and chloramphenicol in presence of their degraded products. Uniform degradation conditions were maintained by refluxing sixteen reaction mixtures for two hours at 80°C using parallel synthesizer including acidic, alkaline and neutral hydrolysis, oxidation and wet heating degradation. Oxidation at room temperature, photochemical and dry heating degradation studies were also carried out. Separation was done on TLC glass plates, pre-coated with silica gel 60F-254 using chloroform: methanol (14:1 v/v. Spots at Rf 0.21 ± 0.02 and Rf 0.41 ± 0.03 were recognized as chloramphenicol and prednisolone acetate, respectively. Quantitative analysis was done through densitometric measurements at multiwavelength (243 nm, λmax of prednisolone acetate and 278 nm, λmax of chloramphenicol, simultaneously. The developed method was optimized and validated as per ICH guidelines. Method was found linear over the concentration range of 200-6000 ng/spot with the correlation coefficient (r2 ± S.D. of 0.9976 ± 3.5 and 0.9920 ± 2.5 for prednisolone acetate and chloramphenicol, respectively. The developed TLC method can be applied for routine analysis of prednisolone acetate and chloramphenicol in presence of their degraded products in their individual and combined pharmaceutical formulations.

  9. Tween 20-stabilized gold nanoparticles combined with adenosine triphosphate-BODIPY conjugates for the fluorescence detection of adenosine with more than 1000-fold selectivity

    Energy Technology Data Exchange (ETDEWEB)

    Hung, Szu-Ying; Shih, Ya-Chen [Department of Chemistry, National Sun Yat-sen University, Taiwan (China); Tseng, Wei-Lung, E-mail: tsengwl@mail.nsysu.edu.tw [Department of Chemistry, National Sun Yat-sen University, Taiwan (China); School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Taiwan (China); Center for Nanoscience and Nanotechnology, National Sun Yat-sen University, Taiwan (China); Center for Stem Cell Research, Kaohsiung Medical University, Taiwan (China)

    2015-02-01

    Graphical abstract: A simple, enzyme-free, label-free, sensitive and selective system was developed for detecting adenosine based on the use of Tween 20-stabilized gold nanoparticles as an efficient quencher for boron dipyrromethene-conjugated adenosine 5′-triphosphate and as a recognition element for adenosine. - Highlights: • The proposed method can detect adenosine with more than 1000-fold selectivity. • The analysis of adenosine is rapid (∼6 min) using the proposed method. • This method provided better sensitivity for adenosine as compared to aptamer-based sensors. • This method can be applied for the determination of adenosine in urine. - Abstract: This study describes the development of a simple, enzyme-free, label-free, sensitive, and selective system for detecting adenosine based on the use of Tween 20-stabilized gold nanoparticles (Tween 20-AuNPs) as an efficient fluorescence quencher for boron dipyrromethene-conjugated adenosine 5′-triphosphate (BODIPY-ATP) and as a recognition element for adenosine. BODIPY-ATP can interact with Tween 20-AuNPs through the coordination between the adenine group of BODIPY-ATP and Au atoms on the NP surface, thereby causing the fluorescence quenching of BODIPY-ATP through the nanometal surface energy transfer (NSET) effect. When adenosine attaches to the NP surface, the attached adenosine exhibits additional electrostatic attraction to BODIPY-ATP. As a result, the presence of adenosine enhances the efficiency of AuNPs in fluorescence quenching of BODIPY-ATP. The AuNP-induced fluorescence quenching of BODIPY-ATP progressively increased with an increase in the concentration of adenosine; the detection limit at a signal-to-noise ratio of 3 for adenosine was determined to be 60 nM. The selectivity of the proposed system was more than 1000-fold for adenosine over any adenosine analogs and other nucleotides. The proposed system combined with a phenylboronic acid-containing column was successfully applied to the

  10. Tween 20-stabilized gold nanoparticles combined with adenosine triphosphate-BODIPY conjugates for the fluorescence detection of adenosine with more than 1000-fold selectivity

    International Nuclear Information System (INIS)

    Hung, Szu-Ying; Shih, Ya-Chen; Tseng, Wei-Lung

    2015-01-01

    Graphical abstract: A simple, enzyme-free, label-free, sensitive and selective system was developed for detecting adenosine based on the use of Tween 20-stabilized gold nanoparticles as an efficient quencher for boron dipyrromethene-conjugated adenosine 5′-triphosphate and as a recognition element for adenosine. - Highlights: • The proposed method can detect adenosine with more than 1000-fold selectivity. • The analysis of adenosine is rapid (∼6 min) using the proposed method. • This method provided better sensitivity for adenosine as compared to aptamer-based sensors. • This method can be applied for the determination of adenosine in urine. - Abstract: This study describes the development of a simple, enzyme-free, label-free, sensitive, and selective system for detecting adenosine based on the use of Tween 20-stabilized gold nanoparticles (Tween 20-AuNPs) as an efficient fluorescence quencher for boron dipyrromethene-conjugated adenosine 5′-triphosphate (BODIPY-ATP) and as a recognition element for adenosine. BODIPY-ATP can interact with Tween 20-AuNPs through the coordination between the adenine group of BODIPY-ATP and Au atoms on the NP surface, thereby causing the fluorescence quenching of BODIPY-ATP through the nanometal surface energy transfer (NSET) effect. When adenosine attaches to the NP surface, the attached adenosine exhibits additional electrostatic attraction to BODIPY-ATP. As a result, the presence of adenosine enhances the efficiency of AuNPs in fluorescence quenching of BODIPY-ATP. The AuNP-induced fluorescence quenching of BODIPY-ATP progressively increased with an increase in the concentration of adenosine; the detection limit at a signal-to-noise ratio of 3 for adenosine was determined to be 60 nM. The selectivity of the proposed system was more than 1000-fold for adenosine over any adenosine analogs and other nucleotides. The proposed system combined with a phenylboronic acid-containing column was successfully applied to the

  11. Assessing community exposure to hazardous air pollutants by combining optical remote sensing and "low-cost" sensor technologies

    Science.gov (United States)

    Pikelnaya, O.; Polidori, A.; Wimmer, R.; Mellqvist, J.; Samuelsson, J.; Marianne, E.; Andersson, P.; Brohede, S.; Izos, O.

    2017-12-01

    Industrial facilities such as refineries and oil processing facilities can be sources of chemicals adversely affecting human health, for example aromatic hydrocarbons and formaldehyde. In an urban setting, such as the South Coast Air Basin (SCAB), exposure to harmful air pollutants (HAP's) for residents of communities neighboring such facilities is of serious concern. Traditionally, exposure assessments are performed by modeling a community exposure using emission inventories and data collected at fixed air monitoring sites. However, recent field measurements found that emission inventories may underestimate HAP emissions from refineries; and HAP measurements data from fixed sites is lacking spatial resolution; as a result, the impact of HAP emissions on communities is highly uncertain. The next generation air monitoring technologies can help address these challenges. For example, dense "low-cost" sensors allow continuous monitoring of concentrations of pollutants within communities with high temporal- and spatial- resolution, and optical remote sensing (ORS) technologies offer measurements of emission fluxes and real-time ground-concentration mapping of HAPs. South Coast Air Quality Management District (SCAQMD) is currently conducting a multi-year study using ORS methods and "low-cost" Volatile Organic Compounds (VOCs) sensors to monitor HAP emissions from selected industrial facilities in the SCAB and their ambient concentrations in neighboring communities. For this purpose, quarterly mobile ORS surveys are conducted to quantify facility-wide emissions for VOCs, aromatic hydrocarbons and HCHO, and to collect ground-concentration profiles of these pollutants inside neighboring communities. Additionally, "low-cost" sensor nodes for deployment in neighborhood(s) downwind of the facilities have been developed in order to obtain long-term, granular data on neighborhood VOC concentrations, During this presentation we will discuss initial results of quarterly ORS

  12. A Meta-Analysis Method to Advance Design of Technology-Based Learning Tool: Combining Qualitative and Quantitative Research to Understand Learning in Relation to Different Technology Features

    Science.gov (United States)

    Zhang, Lin

    2014-01-01

    Educators design and create various technology tools to scaffold students' learning. As more and more technology designs are incorporated into learning, growing attention has been paid to the study of technology-based learning tool. This paper discusses the emerging issues, such as how can learning effectiveness be understood in relation to…

  13. RHSEG and Subdue: Background and Preliminary Approach for Combining these Technologies for Enhanced Image Data Analysis, Mining and Knowledge Discovery

    Science.gov (United States)

    Tilton, James C.; Cook, Diane J.

    2008-01-01

    Under a project recently selected for funding by NASA's Science Mission Directorate under the Applied Information Systems Research (AISR) program, Tilton and Cook will design and implement the integration of the Subdue graph based knowledge discovery system, developed at the University of Texas Arlington and Washington State University, with image segmentation hierarchies produced by the RHSEG software, developed at NASA GSFC, and perform pilot demonstration studies of data analysis, mining and knowledge discovery on NASA data. Subdue represents a method for discovering substructures in structural databases. Subdue is devised for general-purpose automated discovery, concept learning, and hierarchical clustering, with or without domain knowledge. Subdue was developed by Cook and her colleague, Lawrence B. Holder. For Subdue to be effective in finding patterns in imagery data, the data must be abstracted up from the pixel domain. An appropriate abstraction of imagery data is a segmentation hierarchy: a set of several segmentations of the same image at different levels of detail in which the segmentations at coarser levels of detail can be produced from simple merges of regions at finer levels of detail. The RHSEG program, a recursive approximation to a Hierarchical Segmentation approach (HSEG), can produce segmentation hierarchies quickly and effectively for a wide variety of images. RHSEG and HSEG were developed at NASA GSFC by Tilton. In this presentation we provide background on the RHSEG and Subdue technologies and present a preliminary analysis on how RHSEG and Subdue may be combined to enhance image data analysis, mining and knowledge discovery.

  14. Cell surface engineering of Saccharomyces cerevisiae combined with membrane separation technology for xylitol production from rice straw hydrolysate.

    Science.gov (United States)

    Guirimand, Gregory; Sasaki, Kengo; Inokuma, Kentaro; Bamba, Takahiro; Hasunuma, Tomohisa; Kondo, Akihiko

    2016-04-01

    Xylitol, a value-added polyol deriving from D-xylose, is widely used in both the food and pharmaceutical industries. Despite extensive studies aiming to streamline the production of xylitol, the manufacturing cost of this product remains high while demand is constantly growing worldwide. Biotechnological production of xylitol from lignocellulosic waste may constitute an advantageous and sustainable option to address this issue. However, to date, there have been few reports of biomass conversion to xylitol. In the present study, xylitol was directly produced from rice straw hydrolysate using a recombinant Saccharomyces cerevisiae YPH499 strain expressing cytosolic xylose reductase (XR), along with β-glucosidase (BGL), xylosidase (XYL), and xylanase (XYN) enzymes (co-)displayed on the cell surface; xylitol production by this strain did not require addition of any commercial enzymes. All of these enzymes contributed to the consolidated bioprocessing (CBP) of the lignocellulosic hydrolysate to xylitol to produce 5.8 g/L xylitol with 79.5 % of theoretical yield from xylose contained in the biomass. Furthermore, nanofiltration of the rice straw hydrolysate provided removal of fermentation inhibitors while simultaneously increasing sugar concentrations, facilitating high concentration xylitol production (37.9 g/L) in the CBP. This study is the first report (to our knowledge) of the combination of cell surface engineering approach and membrane separation technology for xylitol production, which could be extended to further industrial applications.

  15. [Screening differentially expressed plasma proteins in cold stress rats based on iTRAQ combined with mass spectrometry technology].

    Science.gov (United States)

    Liu, Yan-zhi; Guo, Jing-ru; Peng, Meng-ling; Ma, Li; Zhen, Li; Ji, Hong; Yang, Huan-min

    2015-09-01

    Isobaric tags for relative and absolute quantitation (iTRAQ) combined with mass spectrometry were used to screen differentially expressed plasma proteins in cold stress rats. Thirty health SPF Wistar rats were randomly divided into cold stress group A and control group B, then A and B were randomly divided into 3 groups (n = 5): A1, A2, A3 and B1, B2, B3. The temperature of room raising was (24.0 +/- 0.1) degrees C, and the cold stress temperature was (4.0 +/- 0.1) degrees C. The rats were treated with different temperatures until 12 h. The abdominal aortic blood was collected with heparin anticoagulation suction tube. Then, the plasma was separated for protein extraction, quantitative, enzymolysis, iTHAQ labeling, scx fractionation and mass spectrometry analysis. Totally, 1085 proteins were identified in the test, 39 differentially expressed proteins were screened, including 29 up-regulated proteins and 10 down-regulated proteins. Three important differentially expressed proteins related to cold stress were screened by bioinfonnatics analysis (Minor histocompatihility protein HA-1, Has-related protein Rap-1b, Integrin beta-1). In the experiment, the differentially expressed plasma proteins were successfully screened in cold stress rats. iTRAQ technology provided a good platform to screen protein diaguostic markers on cold stress rats, and laid a good foundation for further. study on animal cold stress mechanism.

  16. Simultaneous removal of nitrogen oxide/nitrogen dioxide/sulfur dioxide from gas streams by combined plasma scrubbing technology.

    Science.gov (United States)

    Chang, Moo Been; Lee, How Ming; Wu, Feeling; Lai, Chi Ren

    2004-08-01

    Oxides of nitrogen (NOx) [nitrogen oxide (NO) + nitrogen dioxide (NO2)] and sulfur dioxide (SO2) are removed individually in traditional air pollution control technologies. This study proposes a combined plasma scrubbing (CPS) system for simultaneous removal of SO2 and NOx. CPS consists of a dielectric barrier discharge (DBD) and wet scrubbing in series. DBD is used to generate nonthermal plasmas for converting NO to NO2. The water-soluble NO2 then can be removed by wet scrubbing accompanied with SO2 removal. In this work, CPS was tested with simulated exhausts in the laboratory and with diesel-generator exhausts in the field. Experimental results indicate that DBD is very efficient in converting NO to NO2. More than 90% removal of NO, NOx, and SO2 can be simultaneously achieved with CPS. Both sodium sulfide (Na2S) and sodium sulfite (Na2SO3) scrubbing solutions are good for NO2 and SO2 absorption. Energy efficiencies for NOx and SO2 removal are 17 and 18 g/kWh, respectively. The technical feasibility of CPS for simultaneous removal of NO, NO2, and SO2 from gas streams is successfully demonstrated in this study. However, production of carbon monoxide as a side-product (approximately 100 ppm) is found and should be considered.

  17. Fed-batch bioreactor performance and cell line stability evaluation of the artificial chromosome expression technology expressing an IgG1 in Chinese hamster ovary cells.

    Science.gov (United States)

    Combs, Rodney G; Yu, Erwin; Roe, Susanna; Piatchek, Michele Bailey; Jones, Heather L; Mott, John; Kennard, Malcolm L; Goosney, Danika L; Monteith, Diane

    2011-01-01

    The artificial chromosome expression (ACE) technology system uses an engineered artificial chromosome containing multiple site-specific recombination acceptor sites for the rapid and efficient construction of stable cell lines. The construction of Chinese hamster ovary(CHO) cell lines expressing an IgG1 monoclonal antibody (MAb) using the ACE system has been previously described (Kennard et al., Biotechnol Bioeng. 2009;104:540-553). To further demonstrate the manufacturing feasibility of the ACE system, four CHO cell lines expressing the human IgG1 MAb 4A1 were evaluated in batch and fed-batch shake flasks and in a 2-L fed-batch bioreactor. The batch shake flasks achieved titers between 0.7 and 1.1 g/L, whereas the fed-batch shake flask process improved titers to 2.5–3.0 g/L. The lead 4A1 ACE cell line achieved titers of 4.0 g/L with an average specific productivity of 40 pg/(cell day) when cultured in a non optimized 2-L fed-batch bioreactor using a completely chemically defined process. Generational stability characterization of the lead 4A1-expressing cell line demonstrated that the cell line was stable for up to 75 days in culture. Product quality attributes of the 4A1 MAb produced by the ACE system during the stability evaluation period were unchanged and also comparable to existing expression technologies such as the CHO-dhfr system. The results of this evaluation demonstrate that a clonal, stable MAb-expressing CHO cell line can be produced using ACE technology that performs competitively using a chemically defined fed-batch bioreactor process with comparable product quality attributes to cell lines generated by existing technologies.

  18. Microplasma radiofrequency technology combined with triamcinolone improved the therapeutic effect on Chinese patients with hypertrophic scar and reduced the risk of tissue atrophy.

    Science.gov (United States)

    Yu, Shui; Li, Hengjin

    2016-01-01

    The current study aimed to assess the value of microplasma radiofrequency technology combined with triamcinolone for the therapy of Chinese patients with hypertrophic scar. A total of 120 participants with hypertrophic scars were enrolled in the current study. Participants were divided into two groups based on sex, and then randomly and evenly divided into four groups (Groups A, B, C, and D). Participants in Group A received microplasma radiofrequency technology combined with triamcinolone. Participants in Group B received microplasma radiofrequency technology combined with normal saline. Participants in Groups C and D received triamcinolone (40 and 10 mg/mL) injected directly into scar. Experienced physicians evaluated the condition of scars according to the Vancouver Scar Scale 1 month before and after the therapy. There was no difference in age, sex, area, height and location of scars, and Vancouver Scar Scale scores before the therapy between any groups (P>0.05 for all). Vancouver Scar Scale scores after the therapy were significantly lower than those before the therapy in all groups (P0.05 for all). Incidences of tissue atrophy after the therapy were significantly lower in Groups A and B than in Group C (P0.05 for all). Microplasma radiofrequency technology combined with triamcinolone improved the therapeutic effect on Chinese patients with hypertrophic scar and reduced the risk of tissue atrophy compared with the use of either microplasma radiofrequency technology or triamcinolone injection alone.

  19. Reduction in adipose tissue volume using a new high-power radiofrequency technology combined with infrared light and mechanical manipulation for body contouring

    OpenAIRE

    Adatto, Maurice A.; Adatto-Neilson, Robyn M.; Morren, Grietje

    2014-01-01

    A growing patient demand for a youthful skin appearance with a favorable body shape has led to the recent development of new noninvasive body contouring techniques. We have previously demonstrated that the combination of bipolar radiofrequency (RF) and optical energies with tissue manipulation is an efficient reshaping modality. Here, we investigated the efficacy and safety of a new high-power version of this combined technology, in terms of adipose tissue reduction and skin tightening. Thirt...

  20. Preliminary Sizing Completed for Single- Stage-To-Orbit Launch Vehicles Powered By Rocket-Based Combined Cycle Technology

    Science.gov (United States)

    Roche, Joseph M.

    2002-01-01

    Single-stage-to-orbit (SSTO) propulsion remains an elusive goal for launch vehicles. The physics of the problem is leading developers to a search for higher propulsion performance than is available with all-rocket power. Rocket-based combined cycle (RBCC) technology provides additional propulsion performance that may enable SSTO flight. Structural efficiency is also a major driving force in enabling SSTO flight. Increases in performance with RBCC propulsion are offset with the added size of the propulsion system. Geometrical considerations must be exploited to minimize the weight. Integration of the propulsion system with the vehicle must be carefully planned such that aeroperformance is not degraded and the air-breathing performance is enhanced. Consequently, the vehicle's structural architecture becomes one with the propulsion system architecture. Geometrical considerations applied to the integrated vehicle lead to low drag and high structural and volumetric efficiency. Sizing of the SSTO launch vehicle (GTX) is itself an elusive task. The weight of the vehicle depends strongly on the propellant required to meet the mission requirements. Changes in propellant requirements result in changes in the size of the vehicle, which in turn, affect the weight of the vehicle and change the propellant requirements. An iterative approach is necessary to size the vehicle to meet the flight requirements. GTX Sizer was developed to do exactly this. The governing geometry was built into a spreadsheet model along with scaling relationships. The scaling laws attempt to maintain structural integrity as the vehicle size is changed. Key aerodynamic relationships are maintained as the vehicle size is changed. The closed weight and center of gravity are displayed graphically on a plot of the synthesized vehicle. In addition, comprehensive tabular data of the subsystem weights and centers of gravity are generated. The model has been verified for accuracy with finite element analysis. The

  1. Duckweed based wastewater stabilization ponds for wastewater treatment (a low cost technology for small urban areas in Zimbabwe)

    Science.gov (United States)

    Dalu, J. M.; Ndamba, J.

    A three-year investigation into the potential use of duckweed based wastewater stabilizations ponds for wastewater treatment was carried out at two small urban areas in Zimbabwe. The study hoped to contribute towards improved environmental management through improving the quality of effluent being discharged into natural waterways. This was to be achieved through the development and facilitation of the use of duckweed based wastewater stabilizations ponds. The study was carried out at Nemanwa and Gutu Growth Points both with a total population of 23 000. The two centers, like more than 70% of Zimbabwe’s small urban areas, relied on algae based ponds for domestic wastewater treatment. The final effluent is used to irrigate gum plantations before finding its way into the nearest streams. Baseline wastewater quality information was collected on a monthly basis for three months after which duckweed ( Lemna minor) was introduced into the maturation ponds to at least 50% pond surface cover. The influent and effluent was then monitored on a monthly basis for chemical, physical and bacteriological parameters as stipulated in the Zimbabwe Water (Waste and Effluent Disposal) regulations of 2000. After five months, the range of parameters tested for was narrowed to include only those that sometimes surpassed the limits. These included: phosphates, nitrates, pH, biological oxygen demand, iron, conductivity, chemical oxygen demand, turbidity, total dissolved solids and total suspended solids. Significant reductions to within permissible limits were obtained for most of the above-mentioned parameters except for phosphates, chemical and biological oxygen demand and turbidity. However, in these cases, more than 60% reductions were observed when the influent and effluent levels were compared. It is our belief that duckweed based waste stabilization ponds can now be used successfully for the treatment of domestic wastewater in small urban areas of Zimbabwe.

  2. The Combination Design of Enabling Technologies in Group Learning: New Study Support Service for Visually Impaired University Students

    Science.gov (United States)

    Tangsri, Chatcai; Na-Takuatoong, Onjaree; Sophatsathit, Peraphon

    2013-01-01

    This article aims to show how the process of new service technology-based development improves the current study support service for visually impaired university students. Numerous studies have contributed to improving assisted aid technology such as screen readers, the development and the use of audiobooks, and technology that supports individual…

  3. Nitrogen removal from coal gasification wastewater by activated carbon technologies combined with short-cut nitrogen removal process.

    Science.gov (United States)

    Zhao, Qian; Han, Hongjun; Hou, Baolin; Zhuang, Haifeng; Jia, Shengyong; Fang, Fang

    2014-11-01

    A system combining granular activated carbon and powdered activated carbon technologies along with shortcut biological nitrogen removal (GAC-PACT-SBNR) was developed to enhance total nitrogen (TN) removal for anaerobically treated coal gasification wastewater with less need for external carbon resources. The TN removal efficiency in SBNR was significantly improved by introducing the effluent from the GAC process into SBNR during the anoxic stage, with removal percentage increasing from 43.8%-49.6% to 68.8%-75.8%. However, the TN removal rate decreased with the progressive deterioration of GAC adsorption. After adding activated sludge to the GAC compartment, the granular carbon had a longer service-life and the demand for external carbon resources became lower. Eventually, the TN removal rate in SBNR was almost constant at approx. 43.3%, as compared to approx. 20.0% before seeding with sludge. In addition, the production of some alkalinity during the denitrification resulted in a net savings in alkalinity requirements for the nitrification reaction and refractory chemical oxygen demand (COD) degradation by autotrophic bacteria in SBNR under oxic conditions. PACT showed excellent resilience to increasing organic loadings. The microbial community analysis revealed that the PACT had a greater variety of bacterial taxons and the dominant species associated with the three compartments were in good agreement with the removal of typical pollutants. The study demonstrated that pre-adsorption by the GAC-sludge process could be a technically and economically feasible method to enhance TN removal in coal gasification wastewater (CGW). Copyright © 2014. Published by Elsevier B.V.

  4. Rapid identification of pearl powder from Hyriopsis cumingii by Tri-step infrared spectroscopy combined with computer vision technology

    Science.gov (United States)

    Liu, Siqi; Wei, Wei; Bai, Zhiyi; Wang, Xichang; Li, Xiaohong; Wang, Chuanxian; Liu, Xia; Liu, Yuan; Xu, Changhua

    2018-01-01

    Pearl powder, an important raw material in cosmetics and Chinese patent medicines, is commonly uneven in quality and frequently adulterated with low-cost shell powder in the market. The aim of this study is to establish an adequate approach based on Tri-step infrared spectroscopy with enhancing resolution combined with chemometrics for qualitative identification of pearl powder originated from three different quality grades of pearls and quantitative prediction of the proportions of shell powder adulterated in pearl powder. Additionally, computer vision technology (E-eyes) can investigate the color difference among different pearl powders and make it traceable to the pearl quality trait-visual color categories. Though the different grades of pearl powder or adulterated pearl powder have almost identical IR spectra, SD-IR peak intensity at about 861 cm- 1 (v2 band) exhibited regular enhancement with the increasing quality grade of pearls, while the 1082 cm- 1 (v1 band), 712 cm- 1 and 699 cm- 1 (v4 band) were just the reverse. Contrastly, only the peak intensity at 862 cm- 1 was enhanced regularly with the increasing concentration of shell powder. Thus, the bands in the ranges of (1550-1350 cm- 1, 730-680 cm- 1) and (830-880 cm- 1, 690-725 cm- 1) could be exclusive ranges to discriminate three distinct pearl powders and identify adulteration, respectively. For massive sample analysis, a qualitative classification model and a quantitative prediction model based on IR spectra was established successfully by principal component analysis (PCA) and partial least squares (PLS), respectively. The developed method demonstrated great potential for pearl powder quality control and authenticity identification in a direct, holistic manner.

  5. Physicochemical and Microstructural Characterization of Corn Starch Edible Films Obtained by a Combination of Extrusion Technology and Casting Technique.

    Science.gov (United States)

    Fitch-Vargas, Perla Rosa; Aguilar-Palazuelos, Ernesto; de Jesús Zazueta-Morales, José; Vega-García, Misael Odín; Valdez-Morales, Jesús Enrique; Martínez-Bustos, Fernando; Jacobo-Valenzuela, Noelia

    2016-09-01

    Starch edible films (EFs) have been widely studied due to their potential in food preservation; however, their application is limited because of their poor mechanical and barrier properties. Because of that, the aim of this work was to use the extrusion technology (Ex T) as a pretreatment of casting technique to change the starch structure in order to obtain EFs with improved physicochemical properties. To this, corn starch and a mixture of plasticizers (sorbitol and glycerol, in different ratios) were processed in a twin screw extruder to generate the starch modification and subsequently casting technique was used for EFs formation. The best conditions of the Ex T and plasticizers concentration were obtained using response surface methodology. All the response variables evaluated, were affected significatively by the Plasticizers Ratio (Sorbitol:Glycerol) (PR (S:G)) and Extrusion Temperature (ET), while the Screw Speed (SS) did not show significant effect on any of these variables. The optimization study showed that the appropriate conditions to obtain EFs with the best mechanical and barrier properties were ET = 89 °C, SS = 66 rpm and PR (S:G) = 79.7:20.3. Once the best conditions were obtained, the optimal treatment was characterized according to its microstructural properties (X-ray diffraction, Scanning Electron Microscopy and Atomic Force Microscopy) to determine the damage caused in the starch during Ex T and casting technique. In conclusion, with the combination of Ex T and casting technique were obtained EFs with greater breaking strength and deformation, as well as lower water vapor permeability than those reported in the literature. © 2016 Institute of Food Technologists®

  6. Acquisition of Co metal from spent lithium-ion battery using emulsion liquid membrane technology and emulsion stability test

    Science.gov (United States)

    Yuliusman; Wulandari, P. T.; Amiliana, R. A.; Huda, M.; Kusumadewi, F. A.

    2018-03-01

    Lithium-ion batteries are the most common type to be used as energy source in mobile phone. The amount of lithium-ion battery wastes is approximated by 200 – 500 ton/year. In one lithium-ion battery, there are 5 – 20% of cobalt metal, depend on the manufacturer. One of the way to recover a valuable metal from waste is leaching process then continued with extraction, which is the aim of this study. Spent lithium-ion batteries will be characterized with EDX and AAS, the result will show the amount of cobalt metal with form of LiCoO2 in the cathode. Hydrochloric acid concentration used is 4 M, temperature 80°C, and reaction time 1 hour. This study will discuss the emulsion stability test on emulsion liquid membrane. The purpose of emulsion stability test in this study was to determine optimum concentration of surfactant and extractant to produce a stable emulsion. Surfactant and extractant used were SPAN 80 and Cyanex 272 respectively with both concentrations varied. Membrane and feed phase ratios used in this experiment was 1 : 2. The optimum results of this study were SPAN 80 concentrations of 10% w/v and Cyanex 272 0.7 M.

  7. mHealth Application Areas and Technology Combinations*. A Comparison of Literature from High and Low/Middle Income Countries.

    Science.gov (United States)

    Abaza, Haitham; Marschollek, Michael

    2017-08-08

    With the continuous and enormous spread of mobile technologies, mHealth has evolved as a new subfield of eHealth. While eHealth is broadly focused on information and communication technologies, mHealth seeks to explore more into mobile devices and wireless communication. Since mobile phone penetration has exceeded other infrastructure in low and middle-income countries (LMICs), mHealth is seen as a promising component to provide pervasive and patient-centered care. The aim of our research work for this paper is to examine the mHealth literature to identify application areas, target diseases, and mHealth service and technology types that are most appropriate for LMICs. Based on the 2011 WHO mHealth report, a combination of search terms, all including the word "mHealth", was identified. A literature review was conducted by searching the PubMed and IEEE Xplore databases. Articles were included if they were published in English, covered an mHealth solution/ intervention, involved the use of a mobile communication device, and included a pilot evaluation study. Articles were excluded if they did not provide sufficient detail on the solution covered or did not focus on clinical efficacy/effectiveness. Cross-referencing was also performed on included articles. 842 articles were retrieved and analyzed, 255 of which met the inclusion criteria. North America had the highest number of applications (n=74) followed by Europe (n=50), Asia (n=44), Africa (n=25), and Australia (n=9). The Middle East (n=5) and South America (n=3) had the least number of studies. The majority of solutions addressed diabetes (n=51), obesity (n=25), CVDs (n=24), HIV (n=18), mental health (n=16), health behaviors (n=16), and maternal and child's health (MCH) (n=11). Fewer solutions addressed asthma (n=7), cancer (n=5), family health planning (n=5), TB (n=3), malaria (n=2), chronic obtrusive pulmonary disease (COPD) (n=2), vision care (n=2), and dermatology (n=2). Other solutions targeted stroke, dental

  8. Combining Drama Pedagogy with Digital Technologies to Support the Language Learning Needs of Newly Arrived Refugee Children: A Classroom Case Study

    Science.gov (United States)

    Dunn, Julie; Bundy, Penny; Woodrow, Nina

    2012-01-01

    Although significant research has been completed that examines the effectiveness of process drama as a pedagogical approach for developing additional languages and further work has focused on the affordances of digital technologies within drama work, scant attention has been paid to the possibilities which a combination of these approaches might…

  9. Technological capabilities of increasing surface quality of workpieces made of titanium alloy VT22 and stability of surface grinding

    Science.gov (United States)

    Soler, Ya I.; Salov, V. M.; Mai, D. S.

    2018-03-01

    Surface grinding of flat workpieces made of alloy VT22 was conducted by the periphery of a highly porous wheel (HPW) from cubic boron nitride CBN30 B107 100 OV K27 КF40 with three processing techniques (ij). They are 10 - cross-feed per stroke, HPW cutting into a workpiece changes alternately from up to down; 12 – cross-feed per double stroke during the up HPW cutting-in at the working stroke; 22 – cross-feed per double stroke during the down HPW cutting-in at the working stroke. With the involvement of artificial neural network models, it was revealed that to improve the quality of surfaces and stability of its formation, grinding should be conducted if ij = 12.

  10. New flexible origination technology based on electron-beam lithography and its integration into security devices in combination with covert features based on DNA authentication

    Science.gov (United States)

    Drinkwater, John K.; Ryzi, Zbynek; Outwater, Chris S.

    2002-04-01

    Embossed diffractive optically variable devices are becoming increasingly familiar security items on plastic cards, banknotes, security documents and on branded goods and media to protect against counterfeit, protect copyright and to evidence tamper. Equally as this devices become both more widely available there is a pressing requirement for security technology upgrades to keep ahead of technology advances available to potential counterfeiters. This paper describes a new generation electron beam DOVID origination technology particularly suitable for high security applications. Covert marking of security devices is provided using the DNA matrix by creating and verifying unique DNA sequences. This integration of this into practical security features in combination with covert features based on DNA matrix authentication and other more straightforwardly authenticable features to provide multi- technology security solutions will be described.

  11. Before Stabilization

    DEFF Research Database (Denmark)

    Plesner, Ursula; Horst, Maja

    2013-01-01

    of the communication about innovations in information and communication technology (ICT), and to contribute to an understanding of how different visions promise particular future configurations of workflows, communication processes, politics, economic models and social relations. Hereby, the paper adds...... to the literature on the relationship between ICTs and organizing, but with a distinct focus on innovation communication and distributed innovation processes taking place before ICTs are stabilized, issues which cannot be captured by studies of diffusion and adaptation of new ICTs within single organizations....

  12. Estimating GHG Reduction from Combinations of Current Best-Available and Future Powertrain and Vehicle Technologies for a Midsized Car Using EPA’s ALPHA Model (SAE 2016-01-0910)

    Science.gov (United States)

    EPA identified the best, or most efficient, engines, transmissions and vehicle technologies, and then used ALPHA to predict the GHG emissions would be from a midsized car incorporating the best combination of these technologies.

  13. Development of corrective measures and site stabilization technologies for shallow land burial facilities at semiarid sites: summary paper

    International Nuclear Information System (INIS)

    Nyhan, J.W.; Abeele, W.V.

    1987-01-01

    The overall purpose of the corrective measures task performed for the national Low-Level Waste Management Program (NLLWMP) has been to develop and test methods that can be used to correct any actual or anticipated problems with new and existing shallow land burial (SLB) sites in a semiarid environment. These field tests have not only evaluated remedial actions, but have also investigated phenomena suspected of being a possible problem at semiarid SLB sites. The approach the authors have taken in developing remedial action and site closure technologies for low-level waste sites is to recognize the physical and biological processes affecting site integrity are interdependent, and therefore, cannot be treated as separate problems. More specifically the field experiments performed for this task were to identify, evaluate, and model erosion control technologies, field test second generation biointrusion barriers, determine by field experiments the extent of upward radionuclide migration due to moisture cycling, and measure the effects of subsidence on remedial action of other system components. In the following sections of this final task summary report, the authors describe the progress made in establishing the facility in which many of these field experiments were performed, the Los Alamos Experimental Engineered Test Facility (EETF), as well as a brief description of the four research areas encompassed by this task. 45 references, 4 figures

  14. RCRA facility stabilization initiative

    International Nuclear Information System (INIS)

    1995-02-01

    The RCRA Facility Stabilization Initiative was developed as a means of implementing the Corrective Action Program's management goals recommended by the RIS for stabilizing actual or imminent releases from solid waste management units that threaten human health and the environment. The overall goal of stabilization is to, as situations warrant, control or abate threats to human health and/or the environment from releases at RCRA facilities, and/or to prevent or minimize the further spread of contamination while long-term remedies are pursued. The Stabilization initiative is a management philosophy and should not be confused with stabilization technologies

  15. Round-Robin Studies on Roll-Processed ITO-free Organic Tandem Solar Cells Combined with Inter-Laboratory Stability Studies

    DEFF Research Database (Denmark)

    Livi, Francesco; Søndergaard, Roar R.; Andersen, Thomas Rieks

    2015-01-01

    Roll-processed, indium tin oxide (ITO)-free, flexible, organic tandem solar cells and modules have been realized and used in round-robin studies as well as in parallel inter-laboratory stability studies. The tandem cells/modules show no significant difference in comparison to their single...

  16. Combining Old and New Stable Isotope Techniques to Evaluate the Impact of Conservation Tillage on Soil Organic Carbon Dynamics and Stability

    International Nuclear Information System (INIS)

    De Clercq, T.; Xu, H.; Mercklx, R.; Heiling, M.; Dercon, G.; Resch, C.

    2016-01-01

    Soil organic matter (SOM) is a major carbon pool. It is a crucial factor for soil quality including several soil physical properties and a major nutrient source for crops. It also plays a significant role in the global carbon cycle. Soils can act as a carbon sink or source depending on land use and agricultural management practices. Some practices such as conservation tillage or no-tillage could increase SOM stocks, particularly in the topsoil, but in the long term it remains to be seen if and how this SOM is stabilized (De Clercq et al., 2015; Govaerts et al., 2009). In order to evaluate the sustainability and efficiency of soil carbon sequestration measures and the impact of different management and environmental factors, information on SOM stability and mean residence time (MRT) is required. However, this information on SOM stability and MRT is expensive to determine via radiocarbon dating, precluding a wide spread use of stability measurements in soil science. But alternative methods based on stable carbon and nitrogen isotopes, can provide this information at a fraction of the cost

  17. Combined effect of carnosol, rosmarinic acid and thymol on the oxidative stability of soybean oil using a simplex centroid mixture design.

    Science.gov (United States)

    Saoudi, Salma; Chammem, Nadia; Sifaoui, Ines; Jiménez, Ignacio A; Lorenzo-Morales, Jacob; Piñero, José E; Bouassida-Beji, Maha; Hamdi, Moktar; L Bazzocchi, Isabel

    2017-08-01

    Oxidation taking place during the use of oil leads to the deterioration of both nutritional and sensorial qualities. Natural antioxidants from herbs and plants are rich in phenolic compounds and could therefore be more efficient than synthetic ones in preventing lipid oxidation reactions. This study was aimed at the valorization of Tunisian aromatic plants and their active compounds as new sources of natural antioxidant preventing oil oxidation. Carnosol, rosmarinic acid and thymol were isolated from Rosmarinus officinalis and Thymus capitatus by column chromatography and were analyzed by nuclear magnetic resonance. Their antioxidant activities were measured by DPPH, ABTS and FRAP assays. These active compounds were added to soybean oil in different proportions using a simplex-centroid mixture design. Antioxidant activity and oxidative stability of oils were determined before and after 20 days of accelerated oxidation at 60 °C. Results showed that bioactive compounds are effective in maintaining oxidative stability of soybean oil. However, the binary interaction of rosmarinic acid and thymol caused a reduction in antioxidant activity and oxidative stability of soybean oil. Optimum conditions for maximum antioxidant activity and oxidative stability were found to be an equal ternary mixture of carnosol, rosmarinic acid and thymol. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  18. Will technological progress be sufficient to stabilize CO2 emissions from air transport in the mid-term?

    International Nuclear Information System (INIS)

    Cheze, Benoit; Chevallier, Julien; Gastineau, Pascal

    2012-01-01

    This article investigates whether anticipated technological progress can be expected to be strong enough to offset carbon dioxide (CO 2 ) emissions resulting from the rapid growth of air transport. Aviation CO 2 emissions projections are provided at the worldwide level and for eight geographical zones until 2025. Total air traffic flows are first forecast using a dynamic panel-data econometric model, and then converted into corresponding quantities of air traffic CO 2 emissions using specific hypotheses and energy factors. None of our nine scenarios appears compatible with the objective of 450 ppm CO 2 -eq. (a.k.a. 'scenario of type I') recommended by the Intergovernmental Panel on Climate Change (IPCC). None is either compatible with the IPCC scenario of type III, which aims at limiting global warming to 3.2 deg. C

  19. Protein secondary structure and stability determined by combining exoproteolysis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

    Science.gov (United States)

    Villanueva, Josep; Villegas, Virtudes; Querol, Enrique; Avilés, Francesc X; Serrano, Luis

    2002-09-01

    In the post-genomic era, several projects focused on the massive experimental resolution of the three-dimensional structures of all the proteins of different organisms have been initiated. Simultaneously, significant progress has been made in the ab initio prediction of protein three-dimensional structure. One of the keys to the success of such a prediction is the use of local information (i.e. secondary structure). Here we describe a new limited proteolysis methodology, based on the use of unspecific exoproteases coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), to map quickly secondary structure elements of a protein from both ends, the N- and C-termini. We show that the proteolytic patterns (mass spectra series) obtained can be interpreted in the light of the conformation and local stability of the analyzed proteins, a direct correlation being observed between the predicted and the experimentally derived protein secondary structure. Further, this methodology can be easily applied to check rapidly the folding state of a protein and characterize mutational effects on protein conformation and stability. Moreover, given global stability information, this methodology allows one to locate the protein regions of increased or decreased conformational stability. All of this can be done with a small fraction of the amount of protein required by most of the other methods for conformational analysis. Thus limited exoproteolysis, together with MALDI-TOF MS, can be a useful tool to achieve quickly the elucidation of protein structure and stability. Copyright 2002 John Wiley & Sons, Ltd.

  20. Combined Natural Gas and Solar Technologies for Heating and Cooling in the City of NIS in Serbia

    Science.gov (United States)

    Stefanović, Velimir P.; Bojić, Milorad Lj.

    2010-06-01

    The use of conventional systems for heat and electricity production in Niš and Serbia means a constant waste of energy, and money. This problem is present in both industrial and public sector. Using conventional systems, means not only low-energy efficient systems, and technologies, but also using very "dirty" technologies, which cause heavy environment pollution. The lack of electricity in our country, and region is also present. The gas pipeline in Niš was finished not long ago, and second gas pipeline is about to be made in the next couple of years. This opens a door for implementing new technologies and the use of new methods for production of heat and electricity, while preserving our environment. This paper reports discussion of this technology with management of public institutions, which use both heat and electricity.

  1. In-line and Real-time Monitoring of Resonant Acoustic Mixing by Near-infrared Spectroscopy Combined with Chemometric Technology for Process Analytical Technology Applications in Pharmaceutical Powder Blending Systems.

    Science.gov (United States)

    Tanaka, Ryoma; Takahashi, Naoyuki; Nakamura, Yasuaki; Hattori, Yusuke; Ashizawa, Kazuhide; Otsuka, Makoto

    2017-01-01

    Resonant acoustic ® mixing (RAM) technology is a system that performs high-speed mixing by vibration through the control of acceleration and frequency. In recent years, real-time process monitoring and prediction has become of increasing interest, and process analytical technology (PAT) systems will be increasingly introduced into actual manufacturing processes. This study examined the application of PAT with the combination of RAM, near-infrared spectroscopy, and chemometric technology as a set of PAT tools for introduction into actual pharmaceutical powder blending processes. Content uniformity was based on a robust partial least squares regression (PLSR) model constructed to manage the RAM configuration parameters and the changing concentration of the components. As a result, real-time monitoring may be possible and could be successfully demonstrated for in-line real-time prediction of active pharmaceutical ingredients and other additives using chemometric technology. This system is expected to be applicable to the RAM method for the risk management of quality.

  2. Combining Sustainable Land Management Technologies to Combat Land Degradation and Improve Rural Livelihoods in Semi-arid Lands in Kenya.

    Science.gov (United States)

    Mganga, K Z; Musimba, N K R; Nyariki, D M

    2015-12-01

    Drylands occupy more than 80% of Kenya's total land mass and contribute immensely to the national economy and society through agriculture, livestock production, tourism, and wild product harvesting. Dryland ecosystems are areas of high climate variability making them vulnerable to the threats of land degradation. Consequently, agropastoralists inhabiting these ecosystems develop mechanisms and technologies to cope with the impacts of climate variability. This study is aimed to; (1) determine what agropastoralists inhabiting a semi-arid ecosystem in Kenya attribute to be the causes and indicators of land degradation, (2) document sustainable land management (SLM) technologies being undertaken to combat land degradation, and (3) identify the factors that influence the choice of these SLM technologies. Vegetation change from preferred indigenous forage grass species to woody vegetation was cited as the main indicator of land degradation. Land degradation was attributed to recurrent droughts and low amounts of rainfall, overgrazing, and unsustainable harvesting of trees for fuelwood production. However, despite the challenges posed by climate variability and recurrent droughts, the local community is engaging in simple SLM technologies including grass reseeding, rainwater harvesting and soil conservation, and dryland agroforestry as a holistic approach combating land degradation and improving their rural livelihoods. The choice of these SLM technologies was mainly driven by their additional benefits to combating land degradation. In conclusion, promoting such simple SLM technologies can help reverse the land degradation trend, improve agricultural production, food security including access to food, and subsequently improve livelihoods of communities inhabiting dryland ecosystems.

  3. Combining Sustainable Land Management Technologies to Combat Land Degradation and Improve Rural Livelihoods in Semi-arid Lands in Kenya

    Science.gov (United States)

    Mganga, K. Z.; Musimba, N. K. R.; Nyariki, D. M.

    2015-12-01

    Drylands occupy more than 80 % of Kenya's total land mass and contribute immensely to the national economy and society through agriculture, livestock production, tourism, and wild product harvesting. Dryland ecosystems are areas of high climate variability making them vulnerable to the threats of land degradation. Consequently, agropastoralists inhabiting these ecosystems develop mechanisms and technologies to cope with the impacts of climate variability. This study is aimed to; (1) determine what agropastoralists inhabiting a semi-arid ecosystem in Kenya attribute to be the causes and indicators of land degradation, (2) document sustainable land management (SLM) technologies being undertaken to combat land degradation, and (3) identify the factors that influence the choice of these SLM technologies. Vegetation change from preferred indigenous forage grass species to woody vegetation was cited as the main indicator of land degradation. Land degradation was attributed to recurrent droughts and low amounts of rainfall, overgrazing, and unsustainable harvesting of trees for fuelwood production. However, despite the challenges posed by climate variability and recurrent droughts, the local community is engaging in simple SLM technologies including grass reseeding, rainwater harvesting and soil conservation, and dryland agroforestry as a holistic approach combating land degradation and improving their rural livelihoods. The choice of these SLM technologies was mainly driven by their additional benefits to combating land degradation. In conclusion, promoting such simple SLM technologies can help reverse the land degradation trend, improve agricultural production, food security including access to food, and subsequently improve livelihoods of communities inhabiting dryland ecosystems.

  4. Technology.

    Science.gov (United States)

    Online-Offline, 1998

    1998-01-01

    Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

  5. Exploring the Fundamentals of Microreactor Technology with Multidisciplinary Lab Experiments Combining the Synthesis and Characterization of Inorganic Nanoparticles

    Science.gov (United States)

    Emmanuel, Noemie; Emonds-Alt, Gauthier; Lismont, Marjorie; Eppe, Gauthier; Monbaliu, Jean-Christophe M.

    2017-01-01

    Multidisciplinary lab experiments combining microfluidics, nanoparticle synthesis, and characterization are presented. These experiments rely on the implementation of affordable yet efficient microfluidic setups based on perfluoroalkoxyalkane (PFA) capillary coils and standard HPLC connectors in upper undergraduate chemistry laboratories.…

  6. Minimum Additive Waste Stabilization (MAWS)

    International Nuclear Information System (INIS)

    1994-02-01

    In the Minimum Additive Waste Stabilization(MAWS) concept, actual waste streams are utilized as additive resources for vitrification, which may contain the basic components (glass formers and fluxes) for making a suitable glass or glassy slag. If too much glass former is present, then the melt viscosity or temperature will be too high for processing; while if there is too much flux, then the durability may suffer. Therefore, there are optimum combinations of these two important classes of constituents depending on the criteria required. The challenge is to combine these resources in such a way that minimizes the use of non-waste additives yet yields a processable and durable final waste form for disposal. The benefit to this approach is that the volume of the final waste form is minimized (waste loading maximized) since little or no additives are used and vitrification itself results in volume reduction through evaporation of water, combustion of organics, and compaction of the solids into a non-porous glass. This implies a significant reduction in disposal costs due to volume reduction alone, and minimizes future risks/costs due to the long term durability and leach resistance of glass. This is accomplished by using integrated systems that are both cost-effective and produce an environmentally sound waste form for disposal. individual component technologies may include: vitrification; thermal destruction; soil washing; gas scrubbing/filtration; and, ion-exchange wastewater treatment. The particular combination of technologies will depend on the waste streams to be treated. At the heart of MAWS is vitrification technology, which incorporates all primary and secondary waste streams into a final, long-term, stabilized glass wasteform. The integrated technology approach, and view of waste streams as resources, is innovative yet practical to cost effectively treat a broad range of DOE mixed and low-level wastes

  7. Rapid, simple and direct detection of Meloidogyne hapla from infected root galls using loop-mediated isothermal amplification combined with FTA technology

    OpenAIRE

    Peng, Huan; Long, Haibo; Huang, Wenkun; Liu, Jing; Cui, Jiangkuan; Kong, Lingan; Hu, Xianqi; Gu, Jianfeng; Peng, Deliang

    2017-01-01

    The northern root-knot nematode (Meloidogyne hapla) is a damaging nematode that has caused serious economic losses worldwide. In the present study, a sensitive, simple and rapid method was developed for detection of M. hapla in infested plant roots by combining a Flinders Technology Associates (FTA) card with loop-mediated isothermal amplification (LAMP). The specific primers of LAMP were designed based on the distinction of internal transcribed spacer (ITS) sequences between M. hapla and oth...

  8. Technology-derived storage solutions for stabilizing insulin in extreme weather conditions I: the ViViCap-1 device.

    Science.gov (United States)

    Pfützner, Andreas; Pesach, Gidi; Nagar, Ron

    2017-06-01

    Injectable life-saving drugs should not be exposed to temperatures 30°C/86°F. Frequently, weather conditions exceed these temperature thresholds in many countries. Insulin is to be kept at 4-8°C/~ 39-47°F until use and once opened, is supposed to be stable for up to 31 days at room temperature (exception: 42 days for insulin levemir). Extremely hot or cold external temperature can lead to insulin degradation in a very short time with loss of its glucose-lowering efficacy. Combined chemical and engineering solutions for heat protection are employed in ViViCap-1 for disposable insulin pens. The device works based on vacuum insulation and heat consumption by phase-change material. Laboratory studies with exposure of ViViCap-1 to hot outside conditions were performed to evaluate the device performance. ViViCap-1 keeps insulin at an internal temperature phase-change process and 'recharges' the device for further use. ViViCap-1 performed within its specifications. The small and convenient device maintains the efficacy and safety of using insulin even when carried under hot weather conditions.

  9. A Bioinformatic Pipeline for Monitoring of the Mutational Stability of Viral Drug Targets with Deep-Sequencing Technology.

    Science.gov (United States)

    Kravatsky, Yuri; Chechetkin, Vladimir; Fedoseeva, Daria; Gorbacheva, Maria; Kravatskaya, Galina; Kretova, Olga; Tchurikov, Nickolai

    2017-11-23

    The efficient development of antiviral drugs, including efficient antiviral small interfering RNAs (siRNAs), requires continuous monitoring of the strict correspondence between a drug and the related highly variable viral DNA/RNA target(s). Deep sequencing is able to provide an assessment of both the general target conservation and the frequency of particular mutations in the different target sites. The aim of this study was to develop a reliable bioinformatic pipeline for the analysis of millions of short, deep sequencing reads corresponding to selected highly variable viral sequences that are drug target(s). The suggested bioinformatic pipeline combines the available programs and the ad hoc scripts based on an original algorithm of the search for the conserved targets in the deep sequencing data. We also present the statistical criteria for the threshold of reliable mutation detection and for the assessment of variations between corresponding data sets. These criteria are robust against the possible sequencing errors in the reads. As an example, the bioinformatic pipeline is applied to the study of the conservation of RNA interference (RNAi) targets in human immunodeficiency virus 1 (HIV-1) subtype A. The developed pipeline is freely available to download at the website http://virmut.eimb.ru/. Brief comments and comparisons between VirMut and other pipelines are also presented.

  10. A Bioinformatic Pipeline for Monitoring of the Mutational Stability of Viral Drug Targets with Deep-Sequencing Technology

    Directory of Open Access Journals (Sweden)

    Yuri Kravatsky

    2017-11-01

    Full Text Available The efficient development of antiviral drugs, including efficient antiviral small interfering RNAs (siRNAs, requires continuous monitoring of the strict correspondence between a drug and the related highly variable viral DNA/RNA target(s. Deep sequencing is able to provide an assessment of both the general target conservation and the frequency of particular mutations in the different target sites. The aim of this study was to develop a reliable bioinformatic pipeline for the analysis of millions of short, deep sequencing reads corresponding to selected highly variable viral sequences that are drug target(s. The suggested bioinformatic pipeline combines the available programs and the ad hoc scripts based on an original algorithm of the search for the conserved targets in the deep sequencing data. We also present the statistical criteria for the threshold of reliable mutation detection and for the assessment of variations between corresponding data sets. These criteria are robust against the possible sequencing errors in the reads. As an example, the bioinformatic pipeline is applied to the study of the conservation of RNA interference (RNAi targets in human immunodeficiency virus 1 (HIV-1 subtype A. The developed pipeline is freely available to download at the website http://virmut.eimb.ru/. Brief comments and comparisons between VirMut and other pipelines are also presented.

  11. Anaerobic digestion of solid slaughterhouse waste: study of biological stabilization by Fourier Transform infrared spectroscopy and thermogravimetry combined with mass spectrometry.

    Science.gov (United States)

    Cuetos, María José; Gómez, Xiomar; Otero, Marta; Morán, Antonio

    2010-07-01

    In this paper, Fourier Transform infrared spectroscopy (FTIR) along with thermogravimetric analysis together with mass spectrometry (TG-MS analysis) were employed to study the organic matter transformation attained under anaerobic digestion of slaughterhouse waste and to establish the stability of the digestates obtained when compared with fresh wastes. Digestate samples studied were obtained from successful digestion and failed systems treating slaughterhouse waste and the organic fraction of municipal solid wastes. The FTIR spectra and TG profiles from well stabilized products (from successful digestion systems) showed an increase in the aromaticity degree and the reduction of volatile content and aliphatic structures as stabilization proceeded. On the other hand, the FTIR spectra of non-stable reactors showed a high aliphaticity degree and fat content. When comparing differential thermogravimetry (DTG) profiles of the feed and digestate samples obtained from all successful anaerobic systems, a reduction in the intensity of the low-temperature range (approximately 300 degrees C) peak was observed, while the weight loss experienced at high-temperature (450-550 degrees C) was variable for the different systems. Compared to the original waste, the intensity of the weight loss peak in the high-temperature range decreased in the reactors with higher hydraulic retention time (HRT) whereas its intensity increased and the peak was displaced to higher temperatures for the digesters with lower HRT.

  12. Performance and stability of low-cost dye-sensitized solar cell based crude and pre-concentrated anthocyanins: Combined experimental and DFT/TDDFT study

    Science.gov (United States)

    Chaiamornnugool, Phrompak; Tontapha, Sarawut; Phatchana, Ratchanee; Ratchapolthavisin, Nattawat; Kanokmedhakul, Somdej; Sang-aroon, Wichien; Amornkitbamrung, Vittaya

    2017-01-01

    The low cost DSSCs utilized by crude and pre-concentrated anthocyanins extracted from six anthocyanin-rich samples including mangosteen pericarp, roselle, red cabbage, Thai berry, black rice and blue pea were fabricated. Their photo-to-current conversion efficiencies and stability were examined. Pre-concentrated extracts were obtained by solid phase extraction (SPE) using C18 cartridge. The results obviously showed that all pre-concentrated extracts performed on photovoltaic performances in DSSCs better than crude extracts except for mangosteen pericarp. The DSSC sensitized by pre-concentrated anthocyanin from roselle and red cabbage showed maximum current efficiency η = 0.71% while DSSC sensitized by crude anthocyanin from mangosteen pericarp reached maximum efficiency η = 0.97%. In addition, pre-concentrated extract based cells possess more stability than those of crude extract based cells. This indicates that pre-concentration of anthocyanin via SPE method is very effective for DSSCs based on good photovoltaic performance and stability. The DFT/TDDFT calculations of electronic and photoelectrochemical properties of the major anthocyanins found in the samples are employed to support the experimental results.

  13. Challenges to a climate stabilizing energy future

    International Nuclear Information System (INIS)

    Green, C.; Dilmaghani, M.; Baksi, S.

    2007-01-01

    The paper surveys the major challenges to stabilizing the atmospheric CO 2 concentration. Climate change, and policies to deal with it, is viewed as an energy problem. The energy problem stems from the fact that no combination of carbon-free energies is currently capable of displacing fossil fuels as the main sources of the world's base load energy requirements. The paper provides rough estimates of the amount of carbon-free energy required to stabilize climate, the potential contribution of 'conventional' carbon-free energies, the contribution of renewable energies, and the size of an 'advanced energy technology gap'. The findings indicate that stabilizing CO 2 concentration will require a long-term commitment to research, develop, and eventually deploy new energy sources and technologies including hydrogen. The paper suggests that the role of technology is what makes stabilizing CO 2 concentration economically feasible. In this respect energy technology and economics are complementary, with advances in the former requiring something more than a reliance on market-based instruments, such as carbon taxes and emission permits. The analysis has implications for the credibility of commitments to target climate change-related factors such as CO 2 emissions.(author)

  14. Challenges to a climate stabilizing energy future

    International Nuclear Information System (INIS)

    Green, Chris; Baksi, Soham; Dilmaghani, Maryam

    2007-01-01

    The paper surveys the major challenges to stabilizing the atmospheric CO 2 concentration. Climate change, and policies to deal with it, is viewed as an energy problem. The energy problem stems from the fact that no combination of carbon-free energies is currently capable of displacing fossil fuels as the main sources of the world's base load energy requirements. The paper provides rough estimates of the amount of carbon-free energy required to stabilize climate, the potential contribution of 'conventional' carbon-free energies, the contribution of renewable energies, and the size of an 'advanced energy technology gap'. The findings indicate that stabilizing CO 2 concentration will require a long-term commitment to research, develop, and eventually deploy new energy sources and technologies including hydrogen. The paper suggests that the role of technology is what makes stabilizing CO 2 concentration economically feasible. In this respect energy technology and economics are complementary, with advances in the former requiring something more than a reliance on market-based instruments, such as carbon taxes and emission permits. The analysis has implications for the credibility of commitments to target climate change-related factors such as CO 2 emissions

  15. Technology interactions among low-carbon energy technologies: What can we learn from a large number of scenarios?

    International Nuclear Information System (INIS)

    McJeon, Haewon C.; Clarke, Leon; Kyle, Page; Wise, Marshall; Hackbarth, Andrew; Bryant, Benjamin P.; Lempert, Robert J.

    2011-01-01

    Advanced low-carbon energy technologies can substantially reduce the cost of stabilizing atmospheric carbon dioxide concentrations. Understanding the interactions between these technologies and their impact on the costs of stabilization can help inform energy policy decisions. Many previous studies have addressed this challenge by exploring a small number of representative scenarios that represent particular combinations of future technology developments. This paper uses a combinatorial approach in which scenarios are created for all combinations of the technology development assumptions that underlie a smaller, representative set of scenarios. We estimate stabilization costs for 768 runs of the Global Change Assessment Model (GCAM), based on 384 different combinations of assumptions about the future performance of technologies and two stabilization goals. Graphical depiction of the distribution of stabilization costs provides first-order insights about the full data set and individual technologies. We apply a formal scenario discovery method to obtain more nuanced insights about the combinations of technology assumptions most strongly associated with high-cost outcomes. Many of the fundamental insights from traditional representative scenario analysis still hold under this comprehensive combinatorial analysis. For example, the importance of carbon capture and storage (CCS) and the substitution effect among supply technologies are consistently demonstrated. The results also provide more clarity regarding insights not easily demonstrated through representative scenario analysis. For example, they show more clearly how certain supply technologies can provide a hedge against high stabilization costs, and that aggregate end-use efficiency improvements deliver relatively consistent stabilization cost reductions. Furthermore, the results indicate that a lack of CCS options combined with lower technological advances in the buildings sector or the transportation sector is

  16. Characterization of chlorinated solvent contamination in limestone using innovative FLUTe® technologies in combination with other methods in a line of evidence approach

    DEFF Research Database (Denmark)

    Broholm, Mette Martina; Janniche, Gry Sander; Mosthaf, Klaus

    2016-01-01

    Characterization of dense non-aqueous phase liquid (DNAPL) source zones in limestone aquifers/bedrock is essential to develop accurate site-specific conceptual models and perform risk assessment. Here innovative field methods were combined to improve determination of source zone architecture......, hydrogeology and contaminant distribution. The FACT™ is a new technology and it was applied and tested at a contaminated site with a limestone aquifer, together with a number of existing methods including wire-line coring with core subsampling, FLUTe® transmissivity profiling and multilevel water sampling...... groundwater sampling (under two flow conditions) and FACT™ sampling and analysis combined with FLUTe® transmissivity profiling and modeling were used to provide a line of evidence for the presence of DNAPL, dissolved and sorbed phase contamination in the limestone fractures and matrix. The combined methods...

  17. Performance of a novel microwave-based treatment technology for atrazine removal and destruction: Sorbent reusability and chemical stability, and effect of water matrices

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Erdan; Hu, Yuanan [State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); Cheng, Hefa, E-mail: hefac@umich.edu [State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); MOE Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871 (China)

    2015-12-15

    Highlights: • Cu{sup 2+} and Fe{sup 3+} in zeolite pores enhance atrazine sorption and MW-induced degradation. • Exchanged zeolites perform well over multiple sorption–regeneration cycles. • Fe{sup 3+} species in the zeolite micropores have much greater stability than those of Cu{sup 2+}. • DOC in natural waters can compromise the sorption capacity of exchanged zeolites. • Iron-exchanged dealuminated Y zeolites hold great promise for practical applications. - Abstract: Transition metal-exchanged dealuminated Y zeolites were used to adsorb atrazine from aqueous solutions, followed by regeneration of the sorbents and destruction of the sorbed atrazine with microwave irradiation. Exchange of copper and iron into the zeolite's micropores significantly enhanced its sorption capacity and selectivity toward atrazine, and increased the microwave-induced degradation rate of the sorbed atrazine by 3–4-folds. Both the copper- and iron-exchanged zeolites could be regenerated and reused multiple times, while the catalytic activity of the latter was more robust due to the much greater chemical stability of Fe{sup 3+} species in the micropores. The presence of humic acid, and common cations and anions had little impact on the sorption of atrazine on the transition metal-exchanged zeolites. In the treatment of atrazine spiked in natural surface water and groundwater samples, sorptive removal of atrazine was found to be impacted by the level of dissolved organic carbon, probably through competition for the micropore spaces and pore blocking, while the water matrices exhibited no strong effect on the microwave-induced degradation of sorbed atrazine. Overall, iron-exchanged dealuminated Y zeolites show great potential for removal and destruction of atrazine from contaminated surface water and groundwater in practical implementation of the novel treatment technology.

  18. Performance of a novel microwave-based treatment technology for atrazine removal and destruction: Sorbent reusability and chemical stability, and effect of water matrices

    International Nuclear Information System (INIS)

    Hu, Erdan; Hu, Yuanan; Cheng, Hefa

    2015-01-01

    Highlights: • Cu"2"+ and Fe"3"+ in zeolite pores enhance atrazine sorption and MW-induced degradation. • Exchanged zeolites perform well over multiple sorption–regeneration cycles. • Fe"3"+ species in the zeolite micropores have much greater stability than those of Cu"2"+. • DOC in natural waters can compromise the sorption capacity of exchanged zeolites. • Iron-exchanged dealuminated Y zeolites hold great promise for practical applications. - Abstract: Transition metal-exchanged dealuminated Y zeolites were used to adsorb atrazine from aqueous solutions, followed by regeneration of the sorbents and destruction of the sorbed atrazine with microwave irradiation. Exchange of copper and iron into the zeolite's micropores significantly enhanced its sorption capacity and selectivity toward atrazine, and increased the microwave-induced degradation rate of the sorbed atrazine by 3–4-folds. Both the copper- and iron-exchanged zeolites could be regenerated and reused multiple times, while the catalytic activity of the latter was more robust due to the much greater chemical stability of Fe"3"+ species in the micropores. The presence of humic acid, and common cations and anions had little impact on the sorption of atrazine on the transition metal-exchanged zeolites. In the treatment of atrazine spiked in natural surface water and groundwater samples, sorptive removal of atrazine was found to be impacted by the level of dissolved organic carbon, probably through competition for the micropore spaces and pore blocking, while the water matrices exhibited no strong effect on the microwave-induced degradation of sorbed atrazine. Overall, iron-exchanged dealuminated Y zeolites show great potential for removal and destruction of atrazine from contaminated surface water and groundwater in practical implementation of the novel treatment technology.

  19. Combining Project-based Instruction, Earth Science Content, and GIS Technology in Teacher Professional Development: Is this Holistic Approach Sustainable?

    Science.gov (United States)

    Rubino-Hare, L.; Bloom, N.; Claesgens, J.; Fredrickson, K.; Henderson-Dahms, C.; Sample, J. C.

    2012-12-01

    From 2009-2011, with support from the National Science Foundation (ITEST, DRL-0929846) and Science Foundation Arizona (MSAG-0412-09), educators, geologists and geographers at Northern Arizona University (NAU) partnered to offer professional development for interdisciplinary teams of secondary and middle school teachers with a focus on project-based instruction (PBI) using geospatial technologies (GST). While participating in professional development teachers received support and were held accountable to NAU staff. They implemented activities and pedagogical strategies presented, increased knowledge, skills, and confidence teaching with project-based instruction integrating GST, and their students demonstrated learning gains. Changes in student understanding are only observed when teachers continue to implement change, so the question remained: did these changes in practice sustain after official project support ended? In order to determine what, if anything, teachers sustained from the professional development and the factors that promoted or hindered sustained use of teaching with GST and PBI, data were collected one to two years following the professional development. Research questions included a) what pedagogical practices did teachers sustain following the professional learning experiences? and b) what contexts were present in schools that supported or limited the use of geospatial technologies as a teaching and learning tool? Findings from this study indicate that teachers fall into three categories of sustaining implementation - reformed implementers, mechanical implementers and non-implementers. School context was less of a factor in level of implementation than teachers' beliefs and philosophy of teaching and teachers' understanding of technology integration (teaching with technology vs. teaching technology). Case studies of teacher experiences will be presented along with implications for future professional development.

  20. Stability indicating high performance thin-layer chromatographic method for simultaneous estimation of pantoprazole sodium and itopride hydrochloride in combined dosage form

    Directory of Open Access Journals (Sweden)

    Deepak Bageshwar

    2011-11-01

    Full Text Available A specific, precise and stability indicating high-performance thin-layer chromatographic method for simultaneous estimation of pantoprazole sodium and itopride hydrochloride in pharmaceutical formulations was developed and validated. The method employed TLC aluminium plates precoated with silica gel 60F254 as the stationary phase. The solvent system consisted of methanol:water:ammonium acetate; 4.0:1.0:0.5 (v/v/v. This system was found to give compact and dense spots for both itopride hydrochloride (Rf value of 0.55±0.02 and pantoprazole sodium (Rf value of 0.85±0.04. Densitometric analysis of both drugs was carried out in the reflectance–absorbance mode at 289 nm. The linear regression analysis data for the calibration plots showed a good linear relationship with R2=0.9988±0.0012 in the concentration range of 100–400 ng for pantoprazole sodium. Also, the linear regression analysis data for the calibration plots showed a good linear relationship with R2=0.9990±0.0008 in the concentration range of 200–1200 ng for itopride hydrochloride. The method was validated for specificity, precision, robustness and recovery. Statistical analysis proves that the method is repeatable and selective for the estimation of both the said drugs. As the method could effectively separate the drug from its degradation products, it can be employed as a stability indicating method. Keywords: Gastroesophageal reflux disease (GERD, Itopride hydrochloride, Pantoprazole sodium, High performance thin layer chromatography (HPTLC, Stability indicating, Forced degradation

  1. The stabilizing potential of anterior, posterior and combined techniques for the reconstruction of a 2-level cervical corpectomy model: biomechanical study and first results of ATPS prototyping.

    Science.gov (United States)

    Koller, Heiko; Schmidt, Rene; Mayer, Michael; Hitzl, Wolfgang; Zenner, Juliane; Midderhoff, Stefan; Middendorf, Stefan; Graf, Nicolaus; Gräf, Nicolaus; Resch, H; Wilke, Hans-Joachim; Willke, Hans-Joachim

    2010-12-01

    Clinical studies reported frequent failure with anterior instrumented multilevel cervical corpectomies. Hence, posterior augmentation was recommended but necessitates a second approach. Thus, an author group evaluated the feasibility, pull-out characteristics, and accuracy of anterior transpedicular screw (ATPS) fixation. Although first success with clinical application of ATPS has already been reported, no data exist on biomechanical characteristics of an ATPS-plate system enabling transpedicular end-level fixation in advanced instabilities. Therefore, we evaluated biomechanical qualities of an ATPS prototype C4-C7 for reduction of range of motion (ROM) and primary stability in a non-destructive setup among five constructs: anterior plate, posterior all-lateral mass screw construct, posterior construct with lateral mass screws C5 + C6 and end-level fixation using pedicle screws unilaterally or bilaterally, and a 360° construct. 12 human spines C3-T1 were divided into two groups. Four constructs were tested in group 1 and three in group 2; the ATPS prototypes were tested in both groups. Specimens were subjected to flexibility test in a spine motion tester at intact state and after 2-level corpectomy C5-C6 with subsequent reconstruction using a distractable cage and one of the osteosynthesis mentioned above. ROM in flexion-extension, axial rotation, and lateral bending was reported as normalized values. All instrumentations but the anterior plate showed significant reduction of ROM for all directions compared to the intact state. The 360° construct outperformed all others in terms of reducing ROM. While there were no significant differences between the 360° and posterior constructs in flexion-extension and lateral bending, the 360° constructs were significantly more stable in axial rotation. Concerning primary stability of ATPS prototypes, there were no significant differences compared to posterior-only constructs in flexion-extension and axial rotation. The

  2. Technology

    Directory of Open Access Journals (Sweden)

    Xu Jing

    2016-01-01

    Full Text Available The traditional answer card reading method using OMR (Optical Mark Reader, most commonly, OMR special card special use, less versatile, high cost, aiming at the existing problems proposed a method based on pattern recognition of the answer card identification method. Using the method based on Line Segment Detector to detect the tilt of the image, the existence of tilt image rotation correction, and eventually achieve positioning and detection of answers to the answer sheet .Pattern recognition technology for automatic reading, high accuracy, detect faster

  3. A Combined MIS/DS Course Uses Lecture Capture Technology to "Level the Playing Field" in Student Numeracy

    Science.gov (United States)

    Popovich, Karen

    2012-01-01

    This paper describes the process taken to develop a quantitative-based and Excel™-driven course that combines "BOTH" Management Information Systems (MIS) and Decision Science (DS) modeling outcomes and lays the foundation for upper level quantitative courses such as operations management, finance and strategic management. In addition,…

  4. Stability of person ability measures in people with acquired brain injury in the use of everyday technology: the test-retest reliability of the Management of Everyday Technology Assessment (META).

    Science.gov (United States)

    Malinowsky, Camilla; Kassberg, Ann-Charlotte; Larsson-Lund, Maria; Kottorp, Anders

    2016-01-01

    To evaluate the test-retest reliability of the Management of Everyday Technology Assessment (META) in a sample of people with acquired brain injury (ABI). The META was administered twice within a two-week period to 25 people with ABI. A Rasch measurement model was used to convert the META ordinal raw scores into equal-interval linear measures of each participant's ability to manage everyday technology (ET). Test-retest reliability of the stability of the person ability measures in the META was examined by a standardized difference Z-test and an intra-class correlations analysis (ICC 1). The results showed that the paired person ability measures generated from the META were stable over the test-retest period for 22 of the 25 subjects. The ICC 1 correlation was 0.63, which indicates good overall reliability. The META demonstrated acceptable test-retest reliability in a sample of people with ABI. The results illustrate the importance of using sufficiently challenging ETs (relative to a person's abilities) to generate stable META measurements over time. Implications for Rehabilitation The findings add evidence regarding the test-retest reliability of the person ability measures generated from the observation assessment META in a sample of people with ABI. The META might support professionals in the evaluation of interventions that are designed to improve clients' performance of activities including the ability to manage ET.

  5. A combined interfacial and in-situ polymerization strategy to construct well-defined core-shell epoxy-containing SiO2-based microcapsules with high encapsulation loading, super thermal stability and nonpolar solvent tolerance

    Directory of Open Access Journals (Sweden)

    Yin Jia

    2016-10-01

    Full Text Available SiO2-based microcapsules containing hydrophobic molecules exhibited potential applications such as extrinsic self-healing, drug delivery, due to outstanding thermal and chemical stability of SiO2. However, to construct SiO2-based microcapsules with both high encapsulation loading and long-term structural stability is still a troublesome issue, limiting their further utilization. We herein design a single-batch route, a combined interfacial and in-situ polymerization strategy, to fabricate epoxy-containing SiO2-based microcapsules with both high encapsulation loading and long-term structural stability. The final SiO2-based microcapsules preserve high encapsulation loading of 85.7 wt% by controlling exclusively hydrolysis and condensed polymerization at oil/water interface in the initial interfacial polymerization step. In the subsequent in-situ polymerization step, the initial SiO2-based microcapsules as seeds could efficiently harvest SiO2 precursors and primary SiO2 particles to finely tune the SiO2 wall thickness, thereby enhancing long-term structural stability of the final SiO2-based microcapsules including high thermal stability with almost no any weight loss until 250°C, and strong tolerance against nonpolar solvents such as CCl4 with almost unchanged core-shell structure and unchanged core weight after immersing into strong solvents for up to 5 days. These SiO2-based microcapsules are extremely suited for processing them into anticorrosive coating in the presence of nonpolar solvents for self-healing application.

  6. Stability indicating high performance thin-layer chromatographic method for simultaneous estimation of pantoprazole sodium and itopride hydrochloride in combined dosage form.

    Science.gov (United States)

    Bageshwar, Deepak; Khanvilkar, Vineeta; Kadam, Vilasrao

    2011-11-01

    A specific, precise and stability indicating high-performance thin-layer chromatographic method for simultaneous estimation of pantoprazole sodium and itopride hydrochloride in pharmaceutical formulations was developed and validated. The method employed TLC aluminium plates precoated with silica gel 60F 254 as the stationary phase. The solvent system consisted of methanol:water:ammonium acetate; 4.0:1.0:0.5 (v/v/v). This system was found to give compact and dense spots for both itopride hydrochloride ( R f value of 0.55±0.02) and pantoprazole sodium ( R f value of 0.85±0.04). Densitometric analysis of both drugs was carried out in the reflectance-absorbance mode at 289 nm. The linear regression analysis data for the calibration plots showed a good linear relationship with R 2 =0.9988±0.0012 in the concentration range of 100-400 ng for pantoprazole sodium. Also, the linear regression analysis data for the calibration plots showed a good linear relationship with R 2 =0.9990±0.0008 in the concentration range of 200-1200 ng for itopride hydrochloride. The method was validated for specificity, precision, robustness and recovery. Statistical analysis proves that the method is repeatable and selective for the estimation of both the said drugs. As the method could effectively separate the drug from its degradation products, it can be employed as a stability indicating method.

  7. Sensing interstitial glucose to nudge active lifestyles (SIGNAL): feasibility of combining novel self-monitoring technologies for persuasive behaviour change.

    Science.gov (United States)

    Whelan, Maxine E; Kingsnorth, Andrew P; Orme, Mark W; Sherar, Lauren B; Esliger, Dale W

    2017-10-08

    Increasing physical activity (PA) reduces the risk of developing diabetes, highlighting the role of preventive medicine approaches. Changing lifestyle behaviours is difficult and is often predicated on the assumption that individuals are willing to change their lifestyles today to reduce the risk of developing disease years or even decades later. The self-monitoring technologies tested in this study will present PA feedback in real time, parallel with acute physiological data. Presenting the immediate health benefits of being more physically active may help enact change by observing the immediate consequences of that behaviour. The present study aims to assess user engagement with the self-monitoring technologies in individuals at moderate-to-high risk of developing type 2 diabetes. 45 individuals with a moderate-to-high risk, aged ≥40 years old and using a compatible smartphone, will be invited to take part in a 7-week protocol. Following 1 week of baseline measurements, participants will be randomised into one of three groups: group 1- glucose feedback followed by biobehavioural feedback (glucose plus PA); group 2-PA feedback followed by biobehavioural feedback; group 3-biobehavioural feedback. A PA monitor and a flash glucose monitor will be deployed during the intervention. Participants will wear both devices throughout the intervention but blinded to feedback depending on group allocation. The primary outcome is the level of participant engagement and will be assessed by device use and smartphone usage. Feasibility will be assessed by the practicality of the technology and screening for diabetes risk. Semistructured interviews will be conducted to explore participant experiences using the technologies. ISRCTN17545949. Registered on 15/05/2017. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  8. Testing of Commercial Milk Production Technology Using A Combination of High Temperature Short Time and Pulsed Electric Field

    OpenAIRE

    Hadi A; Widjanarko SB; Kusnadi J

    2016-01-01

    The development of milk processing technology has grown excessively, and it contains advantage and disadvantage. This study used mixed between PEF (Pulsed Electric Field) and High Temperature Short Time (HTST) to produce milk processed product which is effective and efficient in killing milk microorganism without changing its color, scent, and nutrient content of processed product, therefore producing commercial sterile milk product in accord with milk Indonesian National Standard (SNI). The ...

  9. CuDAS: An interactive curriculum combining pedagogic composition with interactive software for the teaching of music technology

    OpenAIRE

    Leaman, Oliver

    2010-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. Within the framework of education of Music Technology for 16-18 year olds there exists a lack of thorough teaching and learning resources sufficient for a broad understanding of the basics of audio and electronic synthesis. This PhD submission outlines the role of the composer in the classroom in addressing this fundamental issue through the development of a curriculum containing pedago...

  10. Cell Lysis and Detoxification of Cyanotoxins Using a Novel Combination of Microbubble Generation and Plasma Microreactor Technology for Ozonation.

    Science.gov (United States)

    Pandhal, Jagroop; Siswanto, Anggun; Kuvshinov, Dmitriy; Zimmerman, William B; Lawton, Linda; Edwards, Christine

    2018-01-01

    There has been a steady rise in the incidences of algal blooms globally, and worryingly, there is increasing evidence that changes in the global climate are leading to a shift toward cyanobacterial blooms. Many cyanobacterial genera are harmful, producing several potent toxins, including microcystins, for which there are over 90 described analogues. There are a wide range of negative effects associated with these toxins including gastroenteritis, cytotoxicity, hepatotoxicity and neurotoxicity. Although a variety of oxidation based treatment methods have been described, ozonation and advanced oxidation are acknowledged as most effective as they readily oxidise microcystins to non-toxic degradation products. However, most ozonation technologies have challenges for scale up including high costs and sub-optimum efficiencies, hence, a low cost and scalable ozonation technology is needed. Here we designed a low temperature plasma dielectric barrier discharge (DBD) reactor with an incorporated fluidic oscillator for microbubble delivery of ozone. Both technologies have the potential to drastically reduce the costs of ozonation at scale. Mass spectrometry analysis revealed very rapid (cyanotoxins.

  11. Rapid, simple and direct detection of Meloidogyne hapla from infected root galls using loop-mediated isothermal amplification combined with FTA technology.

    Science.gov (United States)

    Peng, Huan; Long, Haibo; Huang, Wenkun; Liu, Jing; Cui, Jiangkuan; Kong, Lingan; Hu, Xianqi; Gu, Jianfeng; Peng, Deliang

    2017-04-03

    The northern root-knot nematode (Meloidogyne hapla) is a damaging nematode that has caused serious economic losses worldwide. In the present study, a sensitive, simple and rapid method was developed for detection of M. hapla in infested plant roots by combining a Flinders Technology Associates (FTA) card with loop-mediated isothermal amplification (LAMP). The specific primers of LAMP were designed based on the distinction of internal transcribed spacer (ITS) sequences between M. hapla and other Meloidogyne spp. The LAMP assay can detect nematode genomic DNA at concentrations low to 1/200 000, which is 100 times more sensitive than conventional PCR. The LAMP was able to highly specifically distinguish M. hapla from other closely related nematode species. Furthermore, the advantages of the FTA-LAMP assay to detect M. hapla were demonstrated by assaying infected root galls that were artificially inoculated. In addition, M. hapla was successfully detected from six of forty-two field samples using FTA-LAMP technology. This study was the first to provide a simple diagnostic assay for M. hapla using the LAMP assay combined with FTA technology. In conclusion, the new FTA-LAMP assay has the potential for diagnosing infestation in the field and managing the pathogen M. hapla.

  12. Combined serum and EPS-urine proteomic analysis using iTRAQ technology for discovery of potential prostate cancer biomarkers.

    Science.gov (United States)

    Zhang, Mo; Chen, Lizhu; Yuan, Zhengwei; Yang, Zeyu; Li, Yue; Shan, Liping; Yin, Bo; Fei, Xiang; Miao, Jianing; Song, Yongsheng

    2016-11-01

    Prostate cancer (PCa) is one of the most common malignant tumors and a major cause of cancer-related death for men worldwide. The aim of our study was to identify potential non-invasive serum and expressed prostatic secretion (EPS)-urine biomarkers for accurate diagnosis of PCa. Here, we performed a combined isobaric tags for relative and absolute quantification (iTRAQ) proteomic analysis to compare protein profiles using pooled serum and EPS-urine samples from 4 groups of patients: benign prostate hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HGPIN), localized PCa and metastatic PCa. The differentially expressed proteins were rigorously selected and further validated in a large and independent cohort using classical ELISA and Western blot assays. Finally, we established a multiplex biomarker panel consisting of 3 proteins (serum PF4V1, PSA, and urinary CRISP3) with an excellent diagnostic capacity to differentiate PCa from BPH [area under the receiver operating characteristic curve (AUC) of 0.941], which showed an evidently greater discriminatory ability than PSA alone (AUC, 0.757) (P<0.001). Importantly, even when PSA level was in the gray zone (4-10 ng/mL), a combination of PF4V1 and CRISP3 could achieve a relatively high diagnostic efficacy (AUC, 0.895). Furthermore, their combination also had the potential to distinguish PCa from HGPIN (AUC, 0.934). Our results demonstrated that the combined application of serum and EPS-urine biomarkers can improve the diagnosis of PCa and provide a new prospect for non-invasive PCa detection.

  13. Broadband Prosthetic Interfaces: Combining Nerve Transfers and Implantable Multichannel EMG Technology to Decode Spinal Motor Neuron Activity

    Directory of Open Access Journals (Sweden)

    Konstantin D. Bergmeister

    2017-07-01

    Full Text Available Modern robotic hands/upper limbs may replace multiple degrees of freedom of extremity function. However, their intuitive use requires a high number of control signals, which current man-machine interfaces do not provide. Here, we discuss a broadband control interface that combines targeted muscle reinnervation, implantable multichannel electromyographic sensors, and advanced decoding to address the increasing capabilities of modern robotic limbs. With targeted muscle reinnervation, nerves that have lost their targets due to an amputation are surgically transferred to residual stump muscles to increase the number of intuitive prosthetic control signals. This surgery re-establishes a nerve-muscle connection that is used for sensing nerve activity with myoelectric interfaces. Moreover, the nerve transfer determines neurophysiological effects, such as muscular hyper-reinnervation and cortical reafferentation that can be exploited by the myoelectric interface. Modern implantable multichannel EMG sensors provide signals from which it is possible to disentangle the behavior of single motor neurons. Recent studies have shown that the neural drive to muscles can be decoded from these signals and thereby the user's intention can be reliably estimated. By combining these concepts in chronic implants and embedded electronics, we believe that it is in principle possible to establish a broadband man-machine interface, with specific applications in prosthesis control. This perspective illustrates this concept, based on combining advanced surgical techniques with recording hardware and processing algorithms. Here we describe the scientific evidence for this concept, current state of investigations, challenges, and alternative approaches to improve current prosthetic interfaces.

  14. In line inspection of multi-diameter and high-pressure pipelines in Brazil using combined technologies: magnetic flux leakage and ultrasonic testing

    Energy Technology Data Exchange (ETDEWEB)

    Ginten, Markus; Brockhaus, Stephan; Bouaoua, Nourreddine; Klein, Stefan [ROSEN Technology and Research Center, Lingen (Germany); Bruening, Franz [ROSEN Brazil, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    The simultaneous use of the magnetic flux leakage (MFL) method and the ultrasonic testing (UT) method on a single in line inspection (ILI) tool has been identified as a versatile and accurate solution for liquid pipelines. The combination of the two methods is complementary to the restrictions of each other. Also, the overall scope of the inspection is enlarged. General wall thinning and largely corroded areas are accurately and reliably scanned with the UT unit, while very detailed information about pitting corrosion is obtained from the MFL measurement. Blind spots of echo loss, as occasionally observed for the UT channels is compensated by the more robust measurement from the MFL sensors. Consequently, this technology has been the method of choice in an in line inspection project of an onshore long distance pipeline in Brazil, facing a variety of corrosion threats. The pipeline consists of several multi-diameter sections of 18/20 inches and 20/22 inches. Furthermore, the high gravity of product in combination with a height profile, an altitude of 1152 m MSL (Mean Sea Level) had to be crossed, leads to a maximum pressure of 220 bar. These boundary conditions had to be considered during the design of the ILI-tool. The paper discusses the experience made so far with the combined technology MFL and UT. The effective use of the inspection tool for the above mentioned pipeline as well as field results from a previous inspection are described. (author)

  15. Long-term temporal stability of the National Institute of Standards and Technology spectral irradiance scale determined with absolute filter radiometers

    International Nuclear Information System (INIS)

    Yoon, Howard W.; Gibson, Charles E.

    2002-01-01

    The temporal stability of the National Institute of Standards and Technology (NIST) spectral irradiance scale as measured with broadband filter radiometers calibrated for absolute spectral irradiance responsivity is described. The working standard free-electron laser (FEL) lamps and the check standard FEL lamps have been monitored with radiometers in the ultraviolet and the visible wavelength regions. The measurements made with these two radiometers reveal that the NIST spectral irradiance scale as compared with an absolute thermodynamic scale has not changed by more than 1.5% in the visible from 1993 to 1999. Similar measurements in the ultraviolet reveal that the corresponding change is less than 1.5% from 1995 to 1999. Furthermore, a check of the spectral irradiance scale by six different filter radiometers calibrated for absolute spectral irradiance responsivity based on the high-accuracy cryogenic radiometer shows that the agreement between the present scale and the detector-based scale is better than 1.3% throughout the visible to the near-infrared wavelength region. These results validate the assigned spectral irradiance of the widely disseminated NIST or NIST-traceable standard sources

  16. Solvation and stabilization of palladium nanoparticles in phosphonium-based ionic liquids: a combined infrared spectroscopic and density functional theory study.

    Science.gov (United States)

    Zvereva, Elena E; Grimme, Stefan; Katsyuba, Sergey A; Ermolaev, Vadim V; Arkhipova, Daria A; Yan, Ning; Miluykov, Vasili A; Sinyashin, Oleg G; Aleksandrov, Alexey

    2014-10-14

    Analysis of infrared spectra of palladium nanoparticles (NPs) immersed in the tri-tert-butyl-R-phosphonium-based ionic liquids (ILs) demonstrates that both cations and anions of the ILs interact with the NPs. According to quantum-chemical simulations of these interactions, the binding energy of anions to the Pd6 cluster, taken as a minimal-size model of the NPs, increases from ∼6 to ∼27 kcal mol(-1) in the order [PF6](-)≈ [BF4](-) < [Tf2N](-) < [OTf](-) < [Br](-)≪ [TFA](-). In contrast, the binding energy for all types of the [Bu(t)3PR](+) cations slightly varies at about ∼22 kcal mol(-1) only moderately depending on the choice of the R moiety (n-pentyl, 2-hydroxyethyl, 2-methoxyethyl, 2-ethoxy-2-oxoethyl). As a result, the energies of interaction between a Pd6 cluster and various ion pairs, formed by the abovementioned counter-ions, follow the order found for the anions and vary from ∼24 to ∼47 kcal mol(-1). These values are smaller than the energy of addition of a Pd atom to a Pdn cluster (∼58 kcal mol(-1)), which suggests kinetic stabilization of the NPs in phosphonium-based ILs rather than thermodynamic stabilization. The results are qualitatively similar to the trends found earlier for interactions between palladium clusters and components of imidazolium-based ILs, in spite of much larger contributions of the London dispersion forces to the binding of the [Bu(t)3PR](+) cations to the cluster (up to 80%) relative to the case of 1-R-3-methylimidazolium cations (up to 40%).

  17. Design and development of decentralized water and wastewater technologies: a combination of safe wastewater disposal and fertilizer production.

    Science.gov (United States)

    Fach, S; Fuchs, S

    2010-01-01

    Modern wastewater treatment plants are often inappropriate for communities in developing countries. Such communities lack the funding, resources and skilled labour required to implement, operate, and maintain these plants. This research was conducted to investigate and establish an appropriate wastewater treatment system for the district of Gunung Kidul, Indonesia. Due to its lack of water during the dry season, this district is considered one of the poorest areas in the nation. First, wastewater was stored in septic tank units for a retention time of 26 days. Anaerobic conditions occurred, resulting in an 80% reduction of initial COD. The retained sludge was well stabilized with great potential, if dewatered, for reuse as fertilizer. Consequently, supernatant was separated for experiments consisting of lab scale aerobic sand filtering unit. Through filtration, further removals of COD (about 30%) and pathogens were achieved. Rich in nitrogen, the resulting effluent could be used for irrigation and soil conditioning. With faecal sludge and also a mixture of septic sludge and food waste, the hydrolysis stage of anaerobic digestion was examined. This paper discusses the laboratory findings in Karlsruhe and the design and implementation of a treatment system in Glompong, Indonesia.

  18. Inventory of future power and heat production technologies. Partial report Energy combines; Inventering av framtidens el- och vaermeproduktionstekniker. Delrapport Energikombinat

    Energy Technology Data Exchange (ETDEWEB)

    Thunman, Henrik; Lind, Fredrik; Johnsson, Filip (Chalmers Univ. of Technology, Goeteborg (Sweden))

    2008-12-15

    This report treats different ways to produce various upgraded biofuels from lignocellulosic materials in so called polygeneration processes. Furthermore the different upgrading technologies are also investigated with respect to co-production of heat and power. The processes investigated are linked to production of - bio pellets (or lignin pellets), dried, grinded and compressed biomass (or lignin); - torrified bio pellets, dried, grinded, heat treated and compressed biomass; - bio-oils or pyrolytic oils, liquefied biomass with crude oil quality; - ethanol via hydrolysis (process where the biomass is divided into sugars and lignin) followed by fermentation; - methane via hydrolysis and fermentation; - methane via indirect gasification and methane via indirect or suspension gasification, - DME (dimethyl ether) via indirect or suspension gasification; - methanol via indirect or suspension gasification; - DME and methanol via methane produced via indirect gasification. Lignocellulosic biomasses are, for example, forest residues or biomass that can be cultivated on degraded lands. The result from this report shows that it is only the production of bio pellets that is fully commercially available today. For all the other polygeneration processes investigated the production of bio-oil and torrified bio pellets stands out from the other processes investigated, as it is the market for the product that holds back the introduction of the technology. For the other technologies one or several components are still not commercialized and the challenges for these technologies are described in the report. Summarizing the efficiencies for the different processes, the processes that produces biofuels for stationary applications, bio pellets, torrified bio pellets and bio-oil, show the highest efficiencies. Accounted for the co-generated power, efficiencies up to 90 % based on ingoing lower heating values of the dry substance fed to the process could be achieved. For the processes

  19. Cell Lysis and Detoxification of Cyanotoxins Using a Novel Combination of Microbubble Generation and Plasma Microreactor Technology for Ozonation

    Directory of Open Access Journals (Sweden)

    Jagroop Pandhal

    2018-04-01

    Full Text Available There has been a steady rise in the incidences of algal blooms globally, and worryingly, there is increasing evidence that changes in the global climate are leading to a shift toward cyanobacterial blooms. Many cyanobacterial genera are harmful, producing several potent toxins, including microcystins, for which there are over 90 described analogues. There are a wide range of negative effects associated with these toxins including gastroenteritis, cytotoxicity, hepatotoxicity and neurotoxicity. Although a variety of oxidation based treatment methods have been described, ozonation and advanced oxidation are acknowledged as most effective as they readily oxidise microcystins to non-toxic degradation products. However, most ozonation technologies have challenges for scale up including high costs and sub-optimum efficiencies, hence, a low cost and scalable ozonation technology is needed. Here we designed a low temperature plasma dielectric barrier discharge (DBD reactor with an incorporated fluidic oscillator for microbubble delivery of ozone. Both technologies have the potential to drastically reduce the costs of ozonation at scale. Mass spectrometry analysis revealed very rapid (<2 min destruction of two pure microcystins (MC-LR and MC-RR, together with removal of by-products even at low flow rate 1 L min−1 where bubble size was 0.56–0.6 mm and the ozone concentration within the liquid was 20 ppm. Toxicity levels were calculated through protein phosphatase inhibition assays and indicated loss of toxicity as well as confirming the by-products were also non-toxic. Finally, treatment of whole Microcystis aeruginosa cells showed that even at these very low ozone levels, cells can be killed and toxins (MC-LR and Desmethyl MC-LR removed. Little change was observed in the first 20 min of treatment followed by rapid increase in extracellular toxins, indicating cell lysis, with most significant release at the higher 3 L min−1 flow rate compared to 1 L

  20. An engineering-economic analysis of combined heat and power technologies in a (mu)grid application

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, Owen; Ouaglal, Boubekeur; Bartholomew, Emily; Marnay, Chris; Bourassa, Norman

    2002-03-01

    This report describes an investigation at Ernesto Orlando Lawrence Berkeley National Laboratory (Berkeley Lab) of the potential for coupling combined heat and power (CHP) with on-site electricity generation to provide power and heating, and cooling services to customers. This research into distributed energy resources (DER) builds on the concept of the microgrid (mGrid), a semiautonomous grouping of power-generating sources that are placed and operated by and for the benefit of its members. For this investigation, a hypothetical small shopping mall (''Microgrid Oaks'') was developed and analyzed for the cost effectiveness of installing CHP to provide the mGrid's energy needs. A mGrid consists of groups of customers pooling energy loads and installing a combination of generation resources that meets the particular mGrid's goals. This study assumes the mGrid is seeking to minimize energy costs. mGrids could operate independently of the macrogrid (the wider power network), but they are usually assumed to be connected, through power electronics, to the macrogrid. The mGrid in this study is assumed to be interconnected to the macrogrid, and can purchase some energy and ancillary services from utility providers.

  1. Some Problems of the Integration of Heat Pump Technology into a System of Combined Heat and Electricity Production

    Directory of Open Access Journals (Sweden)

    G. Böszörményi

    2001-01-01

    Full Text Available The closure of a part of the municipal combined heat and power (CHP plant of Košice city would result in the loss of 200 MW thermal output within a realtively short period of time. The long term development plan for the Košice district heating system concentrates on solving this problem. Taking into account the extremely high (90 % dependence of Slovakia on imported energy sources and the desirability of reducing the emission of pollutantst the alternative of supplying of 100 MW thermal output from geothermal sources is attractive. However the indices of economic efficiency for this alternative are unsatisfactory. Cogeneration of electricity and heat in a CHP plant, the most efficient way of supplying heat to Košice at the present time. If as planned, geothermal heat is fed directly into the district heating network the efficiency would be greatly reduced. An excellent solution of this problem would be a new conception, preferring the utilization of geothermal heat in support of a combined electricity and heat production process. The efficiency of geothermal energy utilization could be increased through a special heat pump. This paper deals with several aspects of the design of a heat pump to be integrated into the system of the CHP plant.

  2. Use of gamma-irradiation technology in combination with edible coating to produce shelf-stable foods

    International Nuclear Information System (INIS)

    Ouattara, B.; Sabato, S.F.; Lacroix, M.

    2002-01-01

    This research was undertaken to determine the effectiveness of low-dose gamma-irradiation combined with edible coatings to produce shelf-stable foods. Three types of commercially distributed food products were investigated: precooked shrimps, ready to cook pizzas, and fresh strawberries. Samples were coated with various formulations of protein-based solutions and irradiated at total doses between 0 and 3 kGy. Samples were stored at 4 deg. C and evaluated periodically for microbial growth. Sensorial analysis was also performed using a nine-point hedonic scale to evaluate the organoleptic characteristics (odor, taste and appearance). The results showed significant (p≤0.05) combined effect of gamma-irradiation and coating on microbial growth (APCs and Pseudomonas putida). The shelf-life extension periods ranged from 3 to 10 days for shrimps and from 7 to 20 days for pizzas, compared to uncoated/unirradiated products. No significant (p>0.05) detrimental effect of gamma-irradiation on sensorial characteristics (odor, taste, appearance) was observed. In strawberries, coating with irradiated protein solutions resulted in significant reduction of the percentage of mold contamination

  3. Cable Stability

    Energy Technology Data Exchange (ETDEWEB)

    Bottura, L [European Organization for Nuclear Research, Geneva (Switzerland)

    2014-07-01

    Superconductor stability is at the core of the design of any successful cable and magnet application. This chapter reviews the initial understanding of the stability mechanism, and reviews matters of importance for stability such as the nature and magnitude of the perturbation spectrum and the cooling mechanisms. Various stability strategies are studied, providing criteria that depend on the desired design and operating conditions.

  4. Mechanical technology unique to laser fusion experimental systems

    International Nuclear Information System (INIS)

    Hurley, C.A.

    1980-01-01

    Hardware design for laser fusion experimental machines has led to a combination of engineering technologies that are critical to the successful operation of these machines. These large opto-mechanical systems are dependent on extreme cleanliness, accommodation to efficient maintenance, and high stability. These three technologies are the primary mechanical engineering criteria for laser fusion devices

  5. Combination of Open Subtotal Calcanectomy and Stabilization With External Fixation as Limb Salvage Procedure in Hindfoot-Infected Diabetic Foot Ulcers.

    Science.gov (United States)

    Dalla Paola, Luca; Carone, Anna; Boscarino, Giulio; Scavone, Giuseppe; Vasilache, Lucian

    2016-12-01

    Diabetic hindfoot ulcers, complicated by osteomyelitis, are associated with a high risk of major amputation. Partial calcanectomy, preceded by an effective management of the infection and of the eventual peripheral artery disease, can be considered as valid therapeutic option. We have evaluated a therapeutic protocol for diabetic hindfoot ulcers complicated by osteomyelitis, which, besides an adequate surgical debridement, considers a reconstructive pathway assisted by the positioning of a circular external fixator. We made a prospective study of a cohort of diabetic patients affected by heel ulcer complicated by osteomyelitis. All patients underwent open partial calcanectomy associated with the positioning of a circular external frame specifically designed for hindfoot stabilization and offloading. A reconstructive procedure was implemented starting with the application of negative pressure wound therapy and coverage with dermal substitute and split thickness skin grafting. From November 2014 to November 2015, 18 consecutive patients were enrolled. Mean follow-up period was 212.3 ± 64.0 days. Healing was achieved in 18 (100%) patients. The mean healing time was 69.0 ± 64.0 days. No major amputation had to be performed during the follow-up. Open partial calcanectomy associated with external fixation and skin reconstruction was as efficient as limb salvage in patients with infected lesions of the hindfoot complicated by calcaneal osteomyelitis.

  6. Effect of Resistant Starch and β-Glucan Combination on Oxidative Stability, Frying Performance, Microbial Count and Shelf Life of Prebiotic Sausage During Refrigerated Storage

    Directory of Open Access Journals (Sweden)

    Roghayeh Amini Sarteshnizi

    2017-01-01

    Full Text Available This study aims to evaluate the performance of two types of prebiotic sausages formulated with resistant starch (RS and β-glucan (BG extract (in ratios of 2.22:1.33 and 2.75:1.88 during frying and chilled storage. The oxidative stability indices and microbial counts were determined. The incorporation of two types of prebiotic dietary fibre increased frying loss and oil absorption. However, the moisture content of prebiotic sausages after production was higher than of conventional sausages and it decreased significantly during storage. The use of sausage sample containing 2.22 % RS and 1.33 % BG as a recommended formulation can decrease fat oxidation of sausages during storage due to antioxidant properties of BG extract, but higher levels of RS and BG could not be used due to further increase in fat oxidation. Total viable count increased up to day 45 and decreased afterwards. The addition of BG extract improved the antioxidant properties of sausages. Additionally, the antimicrobial properties of BG and moisture reduction could inhibit microbial growth. Moreover, the addition of RS caused an increase in thiobarbituric acid and peroxide values.

  7. Effect of Resistant Starch and β-Glucan Combination on Oxidative Stability, Frying Performance, Microbial Count and Shelf Life of Prebiotic Sausage During
Refrigerated Storage

    Science.gov (United States)

    2017-01-01

    Summary This study aims to evaluate the performance of two types of prebiotic sausages formulated with resistant starch (RS) and β-glucan (BG) extract (in ratios of 2.22:1.33 and 2.75:1.88) during frying and chilled storage. The oxidative stability indices and microbial counts were determined. The incorporation of two types of prebiotic dietary fibre increased frying loss and oil absorption. However, the moisture content of prebiotic sausages after production was higher than of conventional sausages and it decreased significantly during storage. The use of sausage sample containing 2.22% RS and 1.33% BG as a recommended formulation can decrease fat oxidation of sausages during storage due to antioxidant properties of BG extract, but higher levels of RS and BG could not be used due to further increase in fat oxidation. Total viable count increased up to day 45 and decreased afterwards. The addition of BG extract improved the antioxidant properties of sausages. Additionally, the antimicrobial properties of BG and moisture reduction could inhibit microbial growth. Moreover, the addition of RS caused an increase in thiobarbituric acid and peroxide values. PMID:29540982

  8. Enhancement of the solubility, thermal stability, and electronic properties of carbon nanotubes functionalized with MEH-PPV: A combined experimental and computational study

    International Nuclear Information System (INIS)

    Prajongtat, P.; Suramitr, S.; Hannongbua, S.; Gleeson, M.P.; Mitsuke, K.

    2013-01-01

    Multi-walled carbon nanotubes (MWCNTs) functionalized with poly[2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylenevinylene] (MWCNT-f-MEH-PPV) nanocomposites were successfully prepared by employing a “grafting from” approach. The content of the functionalizing MEH-PPV in the composites was observed as 76 wt.%. Compared with pristine MWCNTs (p-MWCNT), the aqueous solubility and thermal stability of the former are significantly enhanced. The effect of covalently and non-covalently functionalized nanotubes on dye-sensitized solar cell performance was also studied. Solar cells were successfully fabricated from isolated MEH-PPV, p-MWCNT/MEH-PPV, and MWCNT-f-MEH-PPV/MEH-PPV counter electrodes. The devices based on a MWCNT-f-MEH-PPV/MEH-PPV counter electrode demonstrated the best photovoltaic performance as observed by higher J SC, V OC, and fill factor (FF) values. The experimental phenomena can be explained by quantum-chemical calculations: Charge transfer from MEH-PPV oligomers to nanotubes is greater when covalently functionalized compared with non-covalently functionalized. This suggests that the improvement in the photovoltaic parameters of the cells containing covalently functionalized nanotubes results not only from the higher concentration present in the nanotube films of the counter electrode, but also from the greater electron delocalization between the oligomers and nanotubes. (author)

  9. Insight into the conformational stability of membrane-embedded BamA using a combined solution and solid-state NMR approach

    Energy Technology Data Exchange (ETDEWEB)

    Sinnige, Tessa; Houben, Klaartje [Utrecht University, NMR Spectroscopy, Department of Chemistry, Faculty of Science, Bijvoet Center for Biomolecular Research (Netherlands); Pritisanac, Iva [Physical and Theoretical Chemistry Laboratory (United Kingdom); Renault, Marie [Institute of Pharmacology and Structural Biology (France); Boelens, Rolf; Baldus, Marc, E-mail: m.baldus@uu.nl [Utrecht University, NMR Spectroscopy, Department of Chemistry, Faculty of Science, Bijvoet Center for Biomolecular Research (Netherlands)

    2015-04-15

    The β-barrel assembly machinery (BAM) is involved in folding and insertion of outer membrane proteins in Gram-negative bacteria, a process that is still poorly understood. With its 790 residues, BamA presents a challenge to current NMR methods. We utilized a “divide and conquer” approach in which we first obtained resonance assignments for BamA’s periplasmic POTRA domains 4 and 5 by solution NMR. Comparison of these assignments to solid-state NMR (ssNMR) data obtained on two BamA constructs including the transmembrane domain and one or two soluble POTRA domains suggested that the fold of POTRA domain 5 critically depends on the interface with POTRA 4. Using specific labeling schemes we furthermore obtained ssNMR resonance assignments for residues in the extracellular loop 6 that is known to be crucial for BamA-mediated substrate folding and insertion. Taken together, our data provide novel insights into the conformational stability of membrane-embedded, non-crystalline BamA.

  10. Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan

    Directory of Open Access Journals (Sweden)

    Syed Faisal Ali

    2016-02-01

    Full Text Available The present investigation was focused to formulate semi-solid capsules (SSCs of hydrophobic drug telmisartan (TLMS by encapsulating semi-solid matrix of its solid dispersion (SD in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68, Gelucire 50/13 and Plasdone S630. A total of nine batches (SD1-SD9 were characterized for micromeritic properties, in vitro dissolution behavior and surface characterization. SD4 with 52.43% cumulative drug release (CDR in phosphate buffer, pH 7.4, in 120 min, t50% 44.2 min and DE30min 96.76% was selected for the development of semi-solid capsules. Differential scanning calorimetry of SD4 revealed molecular dispersion of TLMS in Pluronic-F68. SD4 was formulated into SSCs using Gelucire 44/14 and PEG 400 as semi-solid components and PEG 6000 as a suspending agent to achieve reduction in lag time for effective drug dissolution. SSC6 showed maximum in vitro drug dissolution 97.49 % in phosphate buffer, pH 7.4 with in 20 min that was almost a three folds reduction in the time required to achieve similar dissolution by SD. Thus, SSCs present an excellent approach to enhance in vitro dissolution as well as to reduce the lag time of dissolution for poorly water soluble drugs especially to those therapeutic classes that are intended for faster onset of action. Developed approach based on HPMC capsules provided a better alternative to target delivery of telmisartan to the vegetarian population.

  11. Reduction of harmful emissions from a diesel engine fueled by kapok methyl ester using combined coating and SNCR technology

    International Nuclear Information System (INIS)

    Vedharaj, S.; Vallinayagam, R.; Yang, W.M.; Saravanan, C.G.; Chou, S.K.; Chua, K.J.E.; Lee, P.S.

    2014-01-01

    Highlights: • Thermal barrier coating was accomplished by coating the engine components with PSZ. • Under-utilized kapok oil biodiesel was used as renewable fuel in a coated engine. • The BTE of the engine was improved by 9% with reduced BSFC. • CO, HC and smoke were reduced by 40%, 35.3% and 21.4%, respectively. • After implementing SCR assembly, the NO X emission was decreased by 13.4%. - Abstract: This research work has been formulated to reduce the stinging effect of NO X emission on atmospheric environment from a coated diesel engine fueled by biodiesel. As such, in the current study, we attempted to harness the renewable source of energy from in-edible kapok oil, which is normally under-utilized despite being a viable feedstock for biodiesel synthesis. Notably, steam treatment process followed by crushing of the kapok seeds in a mechanical expeller was done to extract large quantities of kapok oil for the application of diesel engine, which is quite distinct of a method adopted herein. The conventional trans-esterification process was availed to synthesize KME (kapok methyl ester) and the physical and thermal properties of it were estimated by ASTM standard methods. Subsequently, two blends of KME with diesel such as B25 (KME – 25% and diesel – 75%) and B50 (KME – 50% and diesel – 50%) were prepared and tested in a single cylinder diesel engine with thermal barrier coating. To help realize the coating process, PSZ (partially stabilized zirconia), a pertinent coating material in respect of its poor thermal conductivity and better durability, has been chosen as the coating material to be applied on engine components by plasma spray coating technique. As an outcome of the coating study, B50 was found to show improved BTE (brake thermal efficiency) than that in an uncoated engine, with notable decrease in major emissions such as HC (hydrocarbon), CO (carbon monoxide) and smoke. However, due to reduction in heat losses and increase in in

  12. Terminator Operon Reporter: combining a transcription termination switch with reporter technology for improved gene synthesis and synthetic biology applications.

    Science.gov (United States)

    Zampini, Massimiliano; Mur, Luis A J; Rees Stevens, Pauline; Pachebat, Justin A; Newbold, C James; Hayes, Finbarr; Kingston-Smith, Alison

    2016-05-25

    Synthetic biology is characterized by the development of novel and powerful DNA fabrication methods and by the application of engineering principles to biology. The current study describes Terminator Operon Reporter (TOR), a new gene assembly technology based on the conditional activation of a reporter gene in response to sequence errors occurring at the assembly stage of the synthetic element. These errors are monitored by a transcription terminator that is placed between the synthetic gene and reporter gene. Switching of this terminator between active and inactive states dictates the transcription status of the downstream reporter gene to provide a rapid and facile readout of the accuracy of synthetic assembly. Designed specifically and uniquely for the synthesis of protein coding genes in bacteria, TOR allows the rapid and cost-effective fabrication of synthetic constructs by employing oligonucleotides at the most basic purification level (desalted) and without the need for costly and time-consuming post-synthesis correction methods. Thus, TOR streamlines gene assembly approaches, which are central to the future development of synthetic biology.

  13. Application of an electrochemical chlorine-generation system combined with solar energy as appropriate technology for water disinfection.

    Science.gov (United States)

    Choi, Jusol; Park, Chan Gyu; Yoon, Jeyong

    2013-02-01

    Affordable water disinfection is key to reducing the waterborne disease experienced worldwide where resources are limited. A simple electrochemical system that can generate chlorine as a disinfectant from the electrolysis of sodium chloride is an appropriate technology to produce clean water, particularly if driven by solar energy. This study examined the affordability of an electrochemical chlorine generation system using solar energy and developed the necessary design information for its implementation. A two-electrode batch reactor, equipped with commercial IrO(2)-coated electrodes and a solar panel (approximate area 0.2 m(2)), was used to produce chlorine from a 35g/L solution of NaCl. Within 1 h, sufficient chlorine (0.8 g) was generated to produce clean drinking water for about 80 people for 1 day (target microorganism: Escherichia coli; daily drinking water requirement: 2 L per person; chlorine demand: 4 mg/L; solar power: 650 W/m(2) in Seoul, Korea. Small household batteries were demonstrated to be a suitable alternative power source when there is insufficient solar irradiation. Using a 1 m(2) solar panel, the reactor would take only 15 min in Seoul, Korea, or 7 min in the tropics (solar power 1300 W/m(2)), to generate 1 g of chlorine. The solar-powered electrochemical chlorine generation system for which design information is provided here is a simple and affordable way to produce chlorine with which to convert contaminated water into clean drinking water.

  14. Application of gold-198 in investigation of technological processes in cellulose and paper industry and in production of combined forage

    International Nuclear Information System (INIS)

    Petkov, P.M.; Kralev, Kh.I.

    1979-01-01

    To label cellulose fibers and sawdust in investigation of acting installations for production of cellulose and semicellulose, gold-198 was used. The aim of investigation was to determine time of material's transfer in the cellulose production shop from the boiler to the outlet from washer and in the semicellulose production shop from the feeding bunker to refiners. Stable labelling of the cellulose fibers and sawdust has been gained, which permitted successfully to perform investigations of two installations in spite of high temperature and pressure and aggressive medium. Gold-198 is also a good indicator in investigations of technological lines of feed mills. After labelling of one of the main components of fodder mixture, it is introduced into mixer in the proportion used in the production for mixing. It is possible to trace process of mixing either by means of continious registering of by means of sampling. As a result of investigations, optimal time of mixing, segregation processes influence of the factory transport and intershop idle stand on the homogenity of product for factories with different equipment, can be determined [ru

  15. Power and cogeneration technology environomic performance typification in the context of CO2 abatement part II: Combined heat and power cogeneration

    International Nuclear Information System (INIS)

    Li, Hongtao; Marechal, Francois; Favrat, Daniel

    2010-01-01

    This is the second of a series of two articles, dealing with a new approach of environomic (thermodynamic, economic and environmental) performance 'Typification' and optimization of power generation technologies. This part treats specifically of combined heat and power (CHP) cogeneration technologies in the context of CO 2 abatement and provides a methodology for a flexible and fast project based CHP system design evaluation. One of the aspect of the approach is the post-optimization integration of the operating and capital costs, in order to effectively deal with the uncertainty of the project specific design and operation conditions (fuel, electricity and heat selling prices, project financial conditions such as investment amortization periods, annual operating hours, etc). In addition the approach also allows to efficiently evaluate the influence of the external cost such as the CO 2 tax level under a tax scheme or the CO 2 permit price in the emission trading market. Application examples, including gas turbine and combined cycles are treated with the proposed methodology, by using superstructure based generic environomic models and a multi-objective optimizer.

  16. Combining ITIL, COBIT and ISO/IEC 27002 for structuring comprehensive information technology for management in organizations

    Directory of Open Access Journals (Sweden)

    Maico Gehrmann

    2012-09-01

    Full Text Available Several methodologies, tools and standards have been designed to help IT management within organizations. Companies seek, with the use of these mechanisms, the placement of IT management and organizational strategies, mainly to ensure that IT helps with the objectives of the business and the results of the organization. Despite the vast amount of options for tools, methodologies and standards available, when they are used independently, these are not sufficiently wide-ranging to meet all the needs of IT management. This document analyzes ITIL, COBIT and ISO/IEC 27002 methodologies through literature review, highlighting their similarities and differences through the comparison between them. From this analysis, an overall structure is proposed which uses a combination of ITIL, COBIT and ISO/IEC 27002 that can be used by any organization as a more comprehensive solution for the handling and servicing of IT management. As any process, there are positive and negative points. Some negative points of a methodology may be strengthened by the positive ones of other methodologies. This creates more efficient processes.

  17. COMBINING ITIL, COBIT AND ISO/IEC 27002 FOR STRUCTURING COMPREHENSIVE INFORMATION TECHNOLOGY FOR MANAGEMENT IN ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Maico Gehrmann

    2012-09-01

    Full Text Available Several methodologies, tools and standards have been designed to help IT management within organizations. Companies seek, with the use of these mechanisms, the placement of IT management and organizational strategies, mainly to ensure that IT helps with the objectives of the business and the results of the organization. Despite the vast amount of options for tools, methodologies and standards available, when they are used independently, these are not sufficiently wide-ranging to meet all the needs of IT management. This document analyzes ITIL, COBIT and ISO/IEC 27002 methodologies through literature review, highlighting their similarities and differences through the comparison between them. From this analysis, an overall structure is proposed which uses a combination of ITIL, COBIT and ISO/IEC 27002 that can be used by any organization as a more comprehensive solution for the handling and servicing of IT management. As any process, there are positive and negative points. Some negative points of a methodology may be strengthened by the positive ones of other methodologies. This creates more efficient processes.

  18. FORMULASI MIKROEMULSI MINYAK DALAM AIR (O/W YANG STABIL MENGGUNAKAN KOMBINASI TIGA SURFAKTAN NON IONIK DENGAN NILAI HLB RENDAH, TINGGI DAN SEDANG Stable O/W Microemulsion Formulation Using Combination of Three Nonionic Surfactants with Low, High and Med

    Directory of Open Access Journals (Sweden)

    Sih Yuwanti

    2012-05-01

    Full Text Available The aim of this research was to determine the proportion of oil, surfactant and water which could produce a stable O/W microemulsion using combination of three nonionic surfactants with low, high and medium HLB values; and to determine the role of surfactant with a medium HLB value in O/W microemulsion formulation. The first group of microemulsions were prepared using combination of Tween 80, Span 80 and Span 40 (80 %:10 %:10 % with dif- ferent proportions of VCO:surfactant (1:3, 1:3.5 dan 1:4.  The second goups of microemulsion were prepared using combination of Tween 80, Span 80 and Span 40 (90 %:5 %:5 % with different proportions of VCO:surfactant 1:4,1:4.5 dan 1:5.  The stability of microemulsion was determined during storage at room temperature and after being ovened at 105 0C 5 hours and centrifuged at 2300 g 15 minutes. Microemulsion stability was determined by measur- ing absorbance of the microemulsion at 502 nm and then converted to turbidity (%.  In order to determine the role of surfactant with a medium HLB value in the formulation of O/W microemulsion, one set microemulsions were made without surfactant with a medium HLB value, and another set of microemulsions were prepared with different ratios of low and medium HLB surfactant (1:1, 2:1 and 1:2. The most stable microemulsion was achieved when the proportion of VCO:surfactant:water was 4:20:76 and combination of Tween 80:Span 80:Span 40 with the ratio of 90:3.33:6.67. A more stable O/W microemulsion could be obtained when surfactant with a medium HLB value was added to O/W microemulsion formulation. Surfactant with a medium HLB value would link the oil phase and water phase with sur- factant layer, interaction of surfactant-oil and surfactant-water increased. It provided a smooth transition between oil phase and water phase, and the microemulsion became more stable. ABSTRAK Tujuan dari penelitian ini adalah untuk menentukan proporsi minyak, surfaktan dan air yang dapat

  19. The Ecological and Economic Assessment of Efficiency of Environmental Technologies for CHPP (Combined Heat And Power Plant)

    Science.gov (United States)

    Rostuntsova, I. A.; Novichkov, S. V.; Zakharov, O. V.; Kochetkov, A. V.

    2017-11-01

    The analysis of the trial-industrial research of the effectiveness of burning water fuel mixtures in steam boilers of medium and high pressure at the combustion of natural gas and fuel oil is carried out. As a result of a research decrease in nitrogen oxide concentration is depending on the amount of moisture pumped to the boilers and type of the incinerated fuel. The theoretical model of the formation of nitrogen oxides in the furnace of the boiler in order to optimize the combustion process with the introduction of moisture, whereby to determine the concentrations of nitrogen oxides formed in the combustion process of the method of expansion of the exponential is received. The dependences of the maximal temperature of a torch, reaction rate of formation of nitrogen oxides, the conditional time of reaction, theoretical concentration of nitrogen oxides taking into account input of moisture in a fire chamber of a copper and coefficient of an exit of nitrogen oxides are defined at combustion of fuel taking into account moisture input. The divergence between the experimental and the theoretical value of the NOx concentration does not exceed 3.8%. The methodical provisions of the economic assessment of concentrations of pollutants reduction when entering the water are drafted. The rate the net present value (NPV) is applied. The optimal water-fuel ratio is selected based on the maximum value of the net present value (NPV). The evaluation of the application of environmental protection measures carried out taking into account the fact that by reducing the emission values in the implementation of this activity will decrease the amount of payment for emissions of polluting substances, which are collected from the profits of the enterprise. The cost estimate for the implementation of environmental activities carried out on the basis of lump-sum costs and current costs in environmental technology (increased fuel and water consumption).

  20. Combined mask and illumination scheme optimization for robust contact patterning on 45nm technology node flash memory devices

    Science.gov (United States)

    Vaglio Pret, Alessandro; Capetti, Gianfranco; Bollin, Maddalena; Cotti, Gina; De Simone, Danilo; Cantù, Pietro; Vaccaro, Alessandro; Soma, Laura

    2008-03-01

    Immersion Lithography is the most important technique for extending optical lithography's capabilities and meeting the requirements of Semiconductor Roadmap. The introduction of immersion tools has recently allowed the development of 45nm technology node in single exposure. Nevertheless the usage of hyper-high NA scanners (NA > 1), some levels still remain very critical to be imaged with sufficient process performances. For memory devices, contact mask is for sure the most challenging layer. Aim of this paper is to present the lithographic assessment of 193nm contact holes process, with k I value of ~0.30 using NA 1.20 immersion lithography (minimum pitch is 100nm). Different issues will be reported, related to mask choices (Binary or Attenuated Phase Shift) and illuminator configurations. First phase of the work will be dedicated to a preliminary experimental screening on a simple test case in order to reduce the variables in the following optimization sections. Based on this analysis we will discard X-Y symmetrical illuminators (Annular, C-Quad) due to poor contrast. Second phase will be dedicated to a full simulation assessment. Different illuminators will be compared, with both mask type and several mask biases. From this study, we will identify some general trends of lithography performances that can be used for the fine tuning of the RET settings. The last phase of the work will be dedicated to find the sensitivity trends for one of the analyzed illuminators. In particular we study the effect of Numerical Aperture, mask bias in both X and Y direction and poles sigma ring-width and centre.

  1. Investigations into the application of a combination of bioventing and biotrickling filter technologies for soil decontamination processes--a transition regime between bioventing and soil vapour extraction.

    Science.gov (United States)

    Magalhães, S M C; Ferreira Jorge, R M; Castro, P M L

    2009-10-30

    Bioventing has emerged as one of the most cost-effective in situ technologies available to address petroleum light-hydrocarbon spills, one of the most common sources of soil pollution. However, the major drawback associated with this technology is the extended treatment time often required. The present study aimed to illustrate how an intended air-injection bioventing technology can be transformed into a soil vapour extraction effort when the air flow rates are pushed to a stripping mode, thus leading to the treatment of the off-gas resulting from volatilisation. As such, a combination of an air-injection bioventing system and a biotrickling filter was applied for the treatment of contaminated soil, the latter aiming at the treatment of the emissions resulting from the bioventing process. With a moisture content of 10%, soil contaminated with toluene at two different concentrations, namely 2 and 14 mg g soil(-1), were treated successfully using an air-injection bioventing system at a constant air flow rate of ca. 0.13 dm(3) min(-1), which led to the removal of ca. 99% toluene, after a period of ca. 5 days of treatment. A biotrickling filter was simultaneously used to treat the outlet gas emissions, which presented average removal efficiencies of ca. 86%. The proposed combination of biotechnologies proved to be an efficient solution for the decontamination process, when an excessive air flow rate was applied, reducing both the soil contamination and the outlet gas emissions, whilst being able to reduce the treatment time required by bioventing only.

  2. Characterization of various Si-photodiode junction combinations and layout specialities in 0.18µm CMOS and HV-CMOS technologies

    Science.gov (United States)

    Jonak-Auer, I.; Synooka, O.; Kraxner, A.; Roger, F.

    2017-12-01

    With the ongoing miniaturization of CMOS technologies the need for integrated optical sensors on smaller scale CMOS nodes arises. In this paper we report on the development and implementation of different optical sensor concepts in high performance 0.18µm CMOS and high voltage (HV) CMOS technologies on three different substrate materials. The integration process is such that complete modularity of the CMOS processes remains untouched and no additional masks or ion implantation steps are necessary for the sensor integration. The investigated processes support 1.8V and 3V standard CMOS functionality as well as HV transistors capable of operating voltages of 20V and 50V. These processes intrinsically offer a wide variety of junction combinations, which can be exploited for optical sensing purposes. The availability of junction depths from submicron to several microns enables the selection of spectral range from blue to infrared wavelengths. By appropriate layout the contributions of photo-generated carriers outside the target spectral range can be kept to a minimum. Furthermore by making use of other features intrinsically available in 0.18µm CMOS and HV-CMOS processes dark current rates of optoelectronic devices can be minimized. We present TCAD simulations as well as spectral responsivity, dark current and capacitance data measured for various photodiode layouts and the influence of different EPI and Bulk substrate materials thereon. We show examples of spectral responsivity of junction combinations optimized for peak sensitivity in the ranges of 400-500nm, 550-650nm and 700-900nm. Appropriate junction combination enables good spectral resolution for colour sensing applications even without any additional filter implementation. We also show that by appropriate use of shallow trenches dark current values of photodiodes can further be reduced.

  3. Reconsidering figures of merit for performance and stability of perovskite photovoltaics

    DEFF Research Database (Denmark)

    Khenkin, M. V.; Anoop, K. M.; Visoly-Fisher, Iris

    2018-01-01

    The development of hybrid organic–inorganic halide perovskite solar cells (PSCs) that combine high performance and operational stability is vital for implementing this technology. Recently, reversible improvement and degradation of PSC efficiency have been reported under illumination–darkness cyc......The development of hybrid organic–inorganic halide perovskite solar cells (PSCs) that combine high performance and operational stability is vital for implementing this technology. Recently, reversible improvement and degradation of PSC efficiency have been reported under illumination......-term irreversible degradation and the reversible diurnal efficiency variation and does not depend on the type of process prevailing in a given perovskite cell....

  4. Winning Combinations

    DEFF Research Database (Denmark)

    Criscuolo, Paola; Laursen, Keld; Reichstein, Toke

    2018-01-01

    examine the effectiveness of different combinations of knowledge sources for achieving innovative performance. We suggest that combinations involving integrative search strategies – combining internal and external knowledge – are the most likely to generate product and process innovation. In this context......, we present the idea that cognitively distant knowledge sources are helpful for innovation only when used in conjunction with knowledge sources that are closer to the focal firm. We also find important differences between product and process innovation, with the former associated with broader searches......Searching for the most rewarding sources of innovative ideas remains a key challenge in management of technological innovation. Yet, little is known about which combinations of internal and external knowledge sources are triggers for innovation. Extending theories about searching for innovation, we...

  5. Using an innovative combination of quality-by-design and green analytical chemistry approaches for the development of a stability indicating UHPLC method in pharmaceutical products.

    Science.gov (United States)

    Boussès, Christine; Ferey, Ludivine; Vedrines, Elodie; Gaudin, Karen

    2015-11-10

    An innovative combination of green chemistry and quality by design (QbD) approach is presented through the development of an UHPLC method for the analysis of the main degradation products of dextromethorphan hydrobromide. QbD strategy was integrated to the field of green analytical chemistry to improve method understanding while assuring quality and minimizing environmental impacts, and analyst exposure. This analytical method was thoroughly evaluated by applying risk assessment and multivariate analysis tools. After a scouting phase aimed at selecting a suitable stationary phase and an organic solvent in accordance with green chemistry principles, quality risk assessment tools were applied to determine the critical process parameters (CPPs). The effects of the CPPs on critical quality attributes (CQAs), i.e., resolutions, efficiencies, and solvent consumption were further evaluated by means of a screening design. A response surface methodology was then carried out to model CQAs as function of the selected CPPs and the optimal separation conditions were determined through a desirability analysis. Resulting contour plots enabled to establish the design space (DS) (method operable design region) where all CQAs fulfilled the requirements. An experimental validation of the DS proved that quality within the DS was guaranteed; therefore no more robustness study was required before the validation. Finally, this UHPLC method was validated using the concept of total error and was used to analyze a pharmaceutical drug product. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Technological tendencies for the improvement of the performance of combined cycle power stations; Tendencias tecnologicas para el mejoramiento del desempeno de centrales de cilco combinado

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez P, Marino; Garduno R, Raul; Chavez T, Rafael [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2001-07-01

    In this article are dealt some the aspects that have turned the combined cycle generating power stations (CCGPS) into the dominant way for the electrical generation in the world. In the first part it is presented the plan of expansion of the national electrical generation and similar information that the U.S.A. has for the CCGPS, which will give an idea of the importance and the impact that has this technology at the moment. The basic characteristics that are necessary to specify in order to satisfy the environmental and operation requirements, and the available technologies to increase the global efficiency of the CCGPS are also exposed. Finally it describes the evolution of the technology of control for CCGPS developed in the Gerencia de Control e Instrumentacion (GCI), as well as the capacities available to support the electrical sector in this technological discipline. [Spanish] En este articulo se tratan algunos de los aspectos que han convertido a las centrales de generacion de ciclo combinado (CGCC) en el modo dominante para la generacion electrica en el mundo. En la primera parte se presenta el plan de expansion de la generacion electrica nacional e informacion similar que los EE.UU. tienen para las CGCC, lo que dara una idea de la importancia y del impacto que tiene actualmente esta tecnologia. Se exponen tambien las caracteristicas principales que es necesario especificar a fin de satisfacer los requerimientos ambientales y de operacion, y las tecnologias disponibles para incrementar la eficiencia global de las CGCC. Finalmente se describe la evolucion de la tecnologia de control para CGCC desarrollada en la Gerencia de Control e Instrumentacion (GCI), asi como las capacidades disponibles para apoyar al sector electrico en esta disciplina tecnologica.

  7. Dynamic Stability of Maglev Systems,

    Science.gov (United States)

    1992-04-01

    AD-A259 178 ANL-92/21 Materials and Components Dynamic Stability of Technology Division Materials and Components Maglev Systems Technology Division...of Maglev Systems Y. Cai, S. S. Chen, and T. M. Mulcahy Materials and Components Technology Division D. M. Rote Center for Transportation Research...of Maglev System with L-Shaped Guideway ......................................... 6 3 Stability of M aglev System s

  8. Study design and rationale of "Synergistic Effect of Combination Therapy with Cilostazol and ProbUcol on Plaque Stabilization and Lesion REgression (SECURE" study: a double-blind randomised controlled multicenter clinical trial

    Directory of Open Access Journals (Sweden)

    Lee Myoungsook

    2011-01-01

    Full Text Available Abstract Background Probucol, a cholesterol-lowering agent that paradoxically also lowers high-density lipoprotein cholesterol has been shown to prevent progression of atherosclerosis. The antiplatelet agent cilostazol, which has diverse antiatherogenic properties, has also been shown to reduce restenosis in previous clinical trials. Recent experimental studies have suggested potential synergy between probucol and cilostazol in preventing atherosclerosis, possibly by suppressing inflammatory reactions and promoting cholesterol efflux. Methods/design The Synergistic Effect of combination therapy with Cilostazol and probUcol on plaque stabilization and lesion REgression (SECURE study is designed as a double-blind, randomised, controlled, multicenter clinical trial to investigate the effect of cilostazol and probucol combination therapy on plaque volume and composition in comparison with cilostazol monotherapy using intravascular ultrasound and Virtual Histology. The primary end point is the change in the plaque volume of index intermediate lesions between baseline and 9-month follow-up. Secondary endpoints include change in plaque composition, neointimal growth after implantation of stents at percutaneous coronary intervention target lesions, and serum levels of lipid components and biomarkers related to atherosclerosis and inflammation. A total of 118 patients will be included in the study. Discussion The SECURE study will deliver important information on the effects of combination therapy on lipid composition and biomarkers related to atherosclerosis, thereby providing insight into the mechanisms underlying the prevention of atherosclerosis progression by cilostazol and probucol. Trial registration number ClinicalTrials (NCT: NCT01031667

  9. Oxidative Stability and Physico-chemical Properties of Meat from Broilers Fed with Dietary Neem Leaf Powder, Spirulina and their Combination

    Directory of Open Access Journals (Sweden)

    Ravi KILLI

    2015-12-01

    Full Text Available This 6 week study was conducted to evaluate the antioxidant potential, maintaining quality and sensory properties of broiler meat from birds fed on dietary neem leaf powder (NLP. A total of 90 Vencobb broiler chicks were randomly allotted to 6 groups of 15 birds in each. Dietary treatments consisted of normal diet (control Group I, feed containing terramycin-200 (TM-200* at the concentration of 0.05% (Group II, feed containing NLP of 0.2% (Group III, feed containing NLP of 0.2% and spirulina of 1% (Group IV, feed containing TM-200 at 0.05% and spirulina of 1% (Group V and feed containing spirulina of 1% (Group VI. At the end of the experiment liver, kidney and muscle samples were collected to evaluate the tissue peroxidation (TBARS and protein carbonyls and antioxidant markers (SOD. Physico-chemical quality determinants of both fresh and preserved meat viz. extract release volume (ERV, water holding capacity (WHC and pH were also studied. TBARS protein carbonyls indicated a significant (P < 0.05 decrease in all the treated groups when compared to control. Superoxide dismutase levels were found to be significantly increased in all the treated groups, in all the tissues collected. Compared to control group, favorable physico-chemical quality determinants were recorded in all the treated groups. The sensory attributes did not show significant (P < 0.05 differences for color, flavor, juiciness, tenderness and overall acceptability. This study indicates enhanced stress tolerance levels, improved meat quality with unaffected consumer acceptance levels of the meat observed in the study, from broilers fed with neem and spirulina either alone or in combinationsș this points out that neem at 0.2% level can be used in poultry diets instead of antibiotic growth promoters (AGP.

  10. Combining plasma gasification and solid oxide cell technologies in advanced power plants for waste to energy and electric energy storage applications.

    Science.gov (United States)

    Perna, Alessandra; Minutillo, Mariagiovanna; Lubrano Lavadera, Antonio; Jannelli, Elio

    2018-03-01

    The waste to energy (WtE) facilities and the renewable energy storage systems have a strategic role in the promotion of the "eco-innovation", an emerging priority in the European Union. This paper aims to propose advanced plant configurations in which waste to energy plants and electric energy storage systems from intermittent renewable sources are combined for obtaining more efficient and clean energy solutions in accordance with the "eco-innovation" approach. The advanced plant configurations consist of an electric energy storage (EES) section based on a solid oxide electrolyzer (SOEC), a waste gasification section based on the plasma technology and a power generation section based on a solid oxide fuel cell (SOFC). The plant configurations differ for the utilization of electrolytic hydrogen and oxygen in the plasma gasification section and in the power generation section. In the first plant configuration IAPGFC (Integrated Air Plasma Gasification Fuel Cell), the renewable oxygen enriches the air stream, that is used as plasma gas in the gasification section, and the renewable hydrogen is used to enrich the anodic stream of the SOFC in the power generation section. In the second plant configuration IHPGFC (Integrated Hydrogen Plasma Gasification Fuel Cell) the renewable hydrogen is used as plasma gas in the plasma gasification section, and the renewable oxygen is used to enrich the cathodic stream of the SOFC in the power generation section. The analysis has been carried out by using numerical models for predicting and comparing the systems performances in terms of electric efficiency and capability in realizing the waste to energy and the electric energy storage of renewable sources. Results have highlighted that the electric efficiency is very high for all configurations (35-45%) and, thanks to the combination with the waste to energy technology, the storage efficiencies are very attractive (in the range 72-92%). Copyright © 2017 Elsevier Ltd. All rights

  11. The United States of America and the People`s Republic of China experts report on integrated gasification combined-cycle technology (IGCC)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    A report written by the leading US and Chinese experts in Integrated Gasification Combined Cycle (IGCC) power plants, intended for high level decision makers, may greatly accelerate the development of an IGCC demonstration project in the People`s Republic of China (PRC). The potential market for IGCC systems in China and the competitiveness of IGCC technology with other clean coal options for China have been analyzed in the report. Such information will be useful not only to the Chinese government but also to US vendors and companies. The goal of this report is to analyze the energy supply structure of China, China`s energy and environmental protection demand, and the potential market in China in order to make a justified and reasonable assessment on feasibility of the transfer of US Clean Coal Technologies to China. The Expert Report was developed and written by the joint US/PRC IGCC experts and will be presented to the State Planning Commission (SPC) by the President of the CAS to ensure consideration of the importance of IGCC for future PRC power production.

  12. Combining microwave resonance technology to multivariate data analysis as a novel PAT tool to improve process understanding in fluid bed granulation.

    Science.gov (United States)

    Lourenço, Vera; Herdling, Thorsten; Reich, Gabriele; Menezes, José C; Lochmann, Dirk

    2011-08-01

    A set of 192 fluid bed granulation batches at industrial scale were in-line monitored using microwave resonance technology (MRT) to determine moisture, temperature and density of the granules. Multivariate data analysis techniques such as multiway partial least squares (PLS), multiway principal component analysis (PCA) and multivariate batch control charts were applied onto collected batch data sets. The combination of all these techniques, along with off-line particle size measurements, led to significantly increased process understanding. A seasonality effect could be put into evidence that impacted further processing through its influence on the final granule size. Moreover, it was demonstrated by means of a PLS that a relation between the particle size and the MRT measurements can be quantitatively defined, highlighting a potential ability of the MRT sensor to predict information about the final granule size. This study has contributed to improve a fluid bed granulation process, and the process knowledge obtained shows that the product quality can be built in process design, following Quality by Design (QbD) and Process Analytical Technology (PAT) principles. Copyright © 2011. Published by Elsevier B.V.

  13. Collaborative National Program for the Development and Performance Testing of Distributed Power Technologies with Emphasis on Combined Heat and Power Applications

    Energy Technology Data Exchange (ETDEWEB)

    Soinski, Arthur; Hanson, Mark

    2006-06-28

    A current barrier to public acceptance of distributed generation (DG) and combined heat and power (CHP) technologies is the lack of credible and uniform information regarding system performance. Under a cooperative agreement, the Association of State Energy Research and Technology Transfer Institutions (ASERTTI) and the U.S. Department of Energy have developed four performance testing protocols to provide a uniform basis for comparison of systems. The protocols are for laboratory testing, field testing, long-term monitoring and case studies. They have been reviewed by a Stakeholder Advisory Committee made up of industry, public interest, end-user, and research community representatives. The types of systems covered include small turbines, reciprocating engines (including Stirling Cycle), and microturbines. The protocols are available for public use and the resulting data is publicly available in an online national database and two linked databases with further data from New York State. The protocols are interim pending comments and other feedback from users. Final protocols will be available in 2007. The interim protocols and the national database of operating systems can be accessed at www.dgdata.org. The project has entered Phase 2 in which protocols for fuel cell applications will be developed and the national and New York databases will continue to be maintained and populated.

  14. Performance on Water Stability of Cement-Foamed Asphalt Cold Recycled Mixture

    OpenAIRE

    Li Junxiao; Fu Wei; Zang Hechao

    2018-01-01

    Through designing the mixture proportion of foamed asphalt cold in-place recycled mixture combined with the water stability experiment, it shows that the addition of cement can obviously improve foamed asphalt mixture’s water stability and the best cement admixture is between 1% ~ 2%; Using digital imaging microscope and SEM technology, the mechanism of increasing on the intensity of foamed asphalt mixture resulted by adding cement was analyzed. It revealed that the cement hydration products ...

  15. New trends in combined use of gonadotropin-releasing hormone antagonists with gonadotropins or pulsatile gonadotropin-releasing hormone in ovulation induction and assisted reproductive technologies.

    Science.gov (United States)

    Gordon, K; Danforth, D R; Williams, R F; Hodgen, G D

    1992-10-01

    The use of gonadotropin-releasing hormone agonists as adjunctive therapy with gonadotropins for ovulation induction in in vitro fertilization and other assisted reproductive technologies has become common clinical practice. With the recent advent of potent gonadotropin-releasing hormone antagonists free from the marked histamine-release effects that stymied earlier compounds, an attractive alternative method may be available. We have established the feasibility of combining gonadotropin-releasing hormone antagonist-induced inhibition of endogenous gonadotropins with exogenous gonadotropin therapy for ovulation induction in a nonhuman primate model. Here, the principal benefits to be gained from using the gonadotropin-releasing hormone antagonist rather than the gonadotropin-releasing hormone agonist are the immediate inhibition of pituitary gonadotropin secretion without the "flare effect," which brings greater safety and convenience for patients and the medical team and saves time and money. We have also recently demonstrated the feasibility of combining gonadotropin-releasing hormone antagonist with pulsatile gonadotropin-releasing hormone therapy for the controlled restoration of gonadotropin secretion and gonadal steroidogenesis culminating in apparently normal (singleton) ovulatory cycles. This is feasible only with gonadotropin-releasing hormone antagonists because, unlike gonadotropin-releasing hormone agonists, they achieve control of the pituitary-ovarian axis without down regulation of the gonadotropin-releasing hormone receptor system. This capacity to override gonadotropin-releasing hormone antagonist-induced suppression of pituitary-ovarian function may allow new treatment modalities to be employed for women who suffer from chronic hyperandrogenemia with polycystic ovarian disease.

  16. Application of digital PWM technology in current transducers

    International Nuclear Information System (INIS)

    Liu Huifang; Hu Zhimin; Li Rui

    2012-01-01

    With the development of DSP technology and mature use of PID technology,, a new program for DC or AC signal measurement is proposed. Combined with the DSP chip timer module and PID algorithm, PWM signals are generated to control the feedback circuit for the compensation current. Finally the measured current value can be obtained according to the ampere-turns compensation current and the measured current. Studies have shown that this technology enables new current transducers have high stability. (authors)

  17. Design of rapid prototype of UAV line-of-sight stabilized control system

    Science.gov (United States)

    Huang, Gang; Zhao, Liting; Li, Yinlong; Yu, Fei; Lin, Zhe

    2018-01-01

    The line-of-sight (LOS) stable platform is the most important technology of UAV (unmanned aerial vehicle), which can reduce the effect to imaging quality from vibration and maneuvering of the aircraft. According to the requirement of LOS stability system (inertial and optical-mechanical combined method) and UAV's structure, a rapid prototype is designed using based on industrial computer using Peripheral Component Interconnect (PCI) and Windows RTX to exchange information. The paper shows the control structure, and circuit system including the inertial stability control circuit with gyro and voice coil motor driven circuit, the optical-mechanical stability control circuit with fast-steering-mirror (FSM) driven circuit and image-deviation-obtained system, outer frame rotary follower, and information-exchange system on PC. Test results show the stability accuracy reaches 5μrad, and prove the effectiveness of the combined line-of-sight stabilization control system, and the real-time rapid prototype runs stable.

  18. [Application of hepatic segment resection combined with rigid choledochoscope in the treatment of complex hepatolithiasis guided by three-dimensional visualization technology].

    Science.gov (United States)

    Xiang, Nan; Fang, Chihua

    2015-05-01

    To study the value of hepatic segment resection combined with rigid choledochoscope by the three-dimensional (3D) visualization technology in the diagnosis and treatment of complex hepatolithiasis. Enhance computed tomography (CT) data of 46 patients with complex hepatolithiasis who were admitted to the Zhujiang Hospital of the Southern Medical University from July 2010 to June 2014 were collected.All of the CT data were imported into the medical image three-dimensional visualization system (MI-3DVS) for 3D reconstruction and individual 3D types. The optimal scope of liver resection and the remnant liver volume were determined according to the individualized liver segments which were made via the distribution and variation of hepatic vein and portal vein, the distribution of bile duct stones and stricture of the bile duct, which provided guidance for intraoperative hepatic lobectomy and rigid choledochoscope for the remnant calculus lithotripsy. Outcomes of individual 3D types: 10 cases of type I, 11 cases of IIa, 23 cases of IIb, 2 cases of IIc, 19 cases coexisted with history of biliary surgery. The variation of hepatic artery was appeared 6 cases. The variation of portal vein was appeared 8 cases. The remaining liver volume for virtual hepatic lobectomy controlled more than 50%. Eighteen cases underwent left lateral hepatectomy, 8 cases underwent left liver resection, 8 cases underwent right posterior lobe of liver resection, 4 cases underwent the right hepatic resection, 4 cases underwent IV segment liver resection, 2 cases underwent right anterior lobe of liver resection, 2 cases underwent left lateral hepatectomy combined with right posterior lobe of liver resection, 26 cases underwent targeting treatment of rapid choledochoscope and preumatic lithotripsy. The actual surgical procedure was consistent with the preoperative surgical planning. There was no postoperative residual liver ischemia,congestion, liver failure occurred in this study. The intraoperative

  19. Hybrid Intelligent Control for Submarine Stabilization

    Directory of Open Access Journals (Sweden)

    Minghui Wang

    2013-05-01

    Full Text Available Abstract While sailing near the sea surface, submarines will often undergo rolling motion caused by wave disturbance. Fierce rolling motion seriously affects their normal operation and even threatens their security. We propose a new control method for roll stabilization. This paper studies hybrid intelligent control combining a fuzzy control, a neural network and extension control technology. Every control strategy can achieve the ideal control effect within the scope of its effective control. The neuro-fuzzy control strategy is used to improve the robustness of the controller. The speed control strategy and the course control strategy are conducted to extend the control range. The paper also proposes the design of the controller and carries out the simulation experiment in different sea conditions. The simulation results show that the control method proposed can indeed effectively improve the control performance of submarine stabilization.

  20. Reconsidering figures of merit for performance and stability of perovskite photovoltaics

    DEFF Research Database (Denmark)

    Khenkin, M. V.; Anoop, K. M.; Galagan, Y.

    2018-01-01

    The development of hybrid organic–inorganic halide perovskite solar cells (PSCs) that combine high performance and operational stability is vital for implementing this technology. Recently, reversible improvement and degradation of PSC efficiency have been reported under illumination–darkness cyc...

  1. Combining multicriteria decision analysis, ethics and health technology assessment: applying the EVIDEM decisionmaking framework to growth hormone for Turner syndrome patients

    Directory of Open Access Journals (Sweden)

    Grégoire Jean-Pierre

    2010-04-01

    Full Text Available Abstract Objectives To test and further develop a healthcare policy and clinical decision support framework using growth hormone (GH for Turner syndrome (TS as a complex case study. Methods The EVIDEM framework was further developed to complement the multicriteria decision analysis (MCDA Value Matrix, that includes 15 quantifiable components of decision clustered in four domains (quality of evidence, disease, intervention and economics, with a qualitative tool including six ethical and health system-related components of decision. An extensive review of the literature was performed to develop a health technology assessment report (HTA tailored to each component of decision, and content was validated by experts. A panel of representative stakeholders then estimated the MCDA value of GH for TS in Canada by assigning weights and scores to each MCDA component of decision and then considered the impact of non-quantifiable components of decision. Results Applying the framework revealed significant data gaps and the importance of aligning research questions with data needs to truly inform decision. Panelists estimated the value of GH for TS at 41% of maximum value on the MCDA scale, with good agreement at the individual level (retest value 40%; ICC: 0.687 and large variation across panelists. Main contributors to this panel specific value were "Improvement of efficacy", "Disease severity" and "Quality of evidence". Ethical considerations on utility, efficiency and fairness as well as potential misuse of GH had mixed effects on the perceived value of the treatment. Conclusions This framework is proposed as a pragmatic step beyond the current cost-effectiveness model, combining HTA, MCDA, values and ethics. It supports systematic consideration of all components of decision and available evidence for greater transparency. Further testing and validation is needed to build up MCDA approaches combined with pragmatic HTA in healthcare decisionmaking.

  2. Reduction in adipose tissue volume using a new high-power radiofrequency technology combined with infrared light and mechanical manipulation for body contouring.

    Science.gov (United States)

    Adatto, Maurice A; Adatto-Neilson, Robyn M; Morren, Grietje

    2014-09-01

    A growing patient demand for a youthful skin appearance with a favorable body shape has led to the recent development of new noninvasive body contouring techniques. We have previously demonstrated that the combination of bipolar radiofrequency (RF) and optical energies with tissue manipulation is an efficient reshaping modality. Here, we investigated the efficacy and safety of a new high-power version of this combined technology, in terms of adipose tissue reduction and skin tightening. Thirty-five patients received one treatment per week over 6 weeks to their abdomen/flank, buttock, or thigh areas and were followed up to 3 months post completion of the treatment protocol. This new device has an increased power in the bipolar RF, as this parameter appears to be the most important energy modality for volume reduction. Patient circumferences were measured and comparisons of baseline and post treatment outcomes were made. Diagnostic ultrasound (US) measurements were performed in 12 patients to evaluate the reduction in adipose tissue volume, and a cutometer device was used to assess improvements in skin tightening. We observed a gradual decline in patient circumferences from baseline to post six treatments. The overall body shaping effect was accompanied with improvement in skin tightening and was clearly noticeable in the comparison of the before and after treatment clinical photographs. These findings correlated with measurements of adipose tissue volume and skin firmness/elasticity using diagnostic US and cutometer, respectively. The thickness of the fat layer showed on average a 29% reduction between baseline and the 1-month follow up. The average reduction in the circumference of the abdomen/flanks, buttocks, and thighs from baseline to the 3-month follow-up was 1.4, 0.5, and 1.2 cm, respectively, and 93% of study participants demonstrated a 1-60% change in fat layer thickness. Patients subjectively described comfort and satisfaction from treatment, and 97% of

  3. [Development of technologies of population health management in Kazakhstan based on an integrated assessment of the combined exposure to environmental factors].

    Science.gov (United States)

    Sraubaev, E N; Serik, B

    2013-01-01

    At present there is overdue necessity of an integral approach to the assessment of health status and the impact of environmental factors on it, in the development of science-based management decisions and programs on improvement of the health status of the population of Kazakhstan and in the increase in life expectancy from the birth and healthy life expectancy. The purpose of the proposed program--improving health and increasing life expectancy from the birth and healthy life expectancy of the population of Kazakhstan. Based on a meta-analysis to justify the target age group in which an implementation of complex of preventive measures will increase both the life expectancy from the birth and healthy life expectancy, to perform a comprehensive health screening for the basic classes of diseases and behavioral characteristics of the target group in the course of a multicentre studies to give a comprehensive hygienic characteristics of the ecological status of the studied regions and to develop the Health Passport of the region, to develop a model of the combined effects of environmental factors on health; to create a theoretical model for the calculation of life expectancy from the birth and healthy life expectancy, taking into account the limits of modifiability of factors that affect them, and justify a comprehensive program of management decisions on modification of factors, to carry out pilot studies on the development and validation technological (managemental) solutions to control modifiable factors that affect life expectancy from the birth and healthy life expectancy.

  4. Use of a Combined Technology of Ultrasonication, Three-Phase Partitioning, and Aqueous Enzymatic Oil Extraction for the Extraction of Oil from Spirogyra sp.

    Directory of Open Access Journals (Sweden)

    Adisheshu Reddy

    2014-01-01

    Full Text Available Algal oil from Spirogyra sp. was extracted using a combined technology of ultrasonication, three-phase partitioning, and aqueous enzymatic oil extraction. Ultrasonication was done to rupture the cell wall and papain was used for an easier release of the trapped oil. The salt concentration for three-phase partitioning, preincubation period with (or without the protease, and its operational temperature were optimized for a maximum possible yield of the oil and the effect of ultrasonication, and three-phase partitioning with (or without the protease were studied. It was found that under optimized conditions at 50% ammonium sulphate concentration using tert-butanol (in 1 : 1, v/v ratio a presonicated and papain treated algal suspension could produce 24% (w/w, dry weight oil within few hours which was ten times higher as compared to the oil obtained by Soxhlet extraction using hexane and two times higher than the oil obtained without using the protease.

  5. Combining novel monitoring tools and precision application technologies for integrated high-tech crop protection in the future (a discussion document).

    Science.gov (United States)

    Zijlstra, Carolien; Lund, Ivar; Justesen, Annemarie F; Nicolaisen, Mogens; Jensen, Peter Kryger; Bianciotto, Valeria; Posta, Katalin; Balestrini, Raffaella; Przetakiewicz, Anna; Czembor, Elzbieta; van de Zande, Jan

    2011-06-01

    The possibility of combining novel monitoring techniques and precision spraying for crop protection in the future is discussed. A generic model for an innovative crop protection system has been used as a framework. This system will be able to monitor the entire cropping system and identify the presence of relevant pests, diseases and weeds online, and will be location specific. The system will offer prevention, monitoring, interpretation and action which will be performed in a continuous way. The monitoring is divided into several parts. Planting material, seeds and soil should be monitored for prevention purposes before the growing period to avoid, for example, the introduction of disease into the field and to ensure optimal growth conditions. Data from previous growing seasons, such as the location of weeds and previous diseases, should also be included. During the growing season, the crop will be monitored at a macroscale level until a location that needs special attention is identified. If relevant, this area will be monitored more intensively at a microscale level. A decision engine will analyse the data and offer advice on how to control the detected diseases, pests and weeds, using precision spray techniques or alternative measures. The goal is to provide tools that are able to produce high-quality products with the minimal use of conventional plant protection products. This review describes the technologies that can be used or that need further development in order to achieve this goal. Copyright © 2011 Society of Chemical Industry.

  6. Combining multi-criteria decision analysis and mini-health technology assessment: A funding decision-support tool for medical devices in a university hospital setting.

    Science.gov (United States)

    Martelli, Nicolas; Hansen, Paul; van den Brink, Hélène; Boudard, Aurélie; Cordonnier, Anne-Laure; Devaux, Capucine; Pineau, Judith; Prognon, Patrice; Borget, Isabelle

    2016-02-01

    At the hospital level, decisions about purchasing new and oftentimes expensive medical devices must take into account multiple criteria simultaneously. Multi-criteria decision analysis (MCDA) is increasingly used for health technology assessment (HTA). One of the most successful hospital-based HTA approaches is mini-HTA, of which a notable example is the Matrix4value model. To develop a funding decision-support tool combining MCDA and mini-HTA, based on Matrix4value, suitable for medical devices for individual patient use in French university hospitals - known as the IDA tool, short for 'innovative device assessment'. Criteria for assessing medical devices were identified from a literature review and a survey of 18 French university hospitals. Weights for the criteria, representing their relative importance, were derived from a survey of 25 members of a medical devices committee using an elicitation technique involving pairwise comparisons. As a test of its usefulness, the IDA tool was applied to two new drug-eluting beads (DEBs) for transcatheter arterial chemoembolization. The IDA tool comprises five criteria and weights for each of two over-arching categories: risk and value. The tool revealed that the two new DEBs conferred no additional value relative to DEBs currently available. Feedback from participating decision-makers about the IDA tool was very positive. The tool could help to promote a more structured and transparent approach to HTA decision-making in French university hospitals. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Technical evaluation of biomass gasification technology integrated with combined cycle using bagasse as fuel; Avaliacao tecnica da tecnologia de gaseificacao de biomassa integrada a ciclos combinados utilizando bagaco como combustivel

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz, Pablo Silva; Venturini, Osvaldo Jose; Lora, Electo Silva [Universidade Federal de Itajuba (NEST/UNIFEI), MG (Brazil). Nucleo de Excelencia em Geracao Termeletrica e Distribuida], email: pablo.silvaortiz@gmail.com; Campo, Andres Perez [Universidade Automona de Bucaramanga (UNAB) (Colombia). Fac. de Engenharia Fisico- Mecanica, Engenharia em Energia

    2010-07-01

    Biomass Integrated Gasification Combined Cycle (BIGCC) was identified as an advanced technology with potential to be competitive for electricity generation. The BIGCC technology uses biomass and the sub products of some industrial sectors processing, like sugar cane, as feedstock. The current Brazilian energy matrix is mainly based on renewable generation sources, making it important to assess these gasification technologies in the production of sugar, ethanol and electricity. In this work, a technical evaluation of the technologies incorporated in BIGCC power plants is done: the gasification process and the combined cycle power plant. On the other hand, the generated costs of these systems are analyzed, and the potential for implementation in Brazil plants from sugar cane bagasse is studied, in which a 10% increase in efficiency is obtained. (author)

  8. A Synergistic Combination of Advanced Separation and Chemical Scale Inhibitor Technologies for Efficient Use of Imparied Water As Cooling Water in Coal-based Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Jasbir Gill

    2010-08-30

    Nalco Company is partnering with Argonne National Laboratory (ANL) in this project to jointly develop advanced scale control technologies that will provide cost-effective solutions for coal-based power plants to operate recirculating cooling water systems at high cycles using impaired waters. The overall approach is to use combinations of novel membrane separations and scale inhibitor technologies that will work synergistically, with membrane separations reducing the scaling potential of the cooling water and scale inhibitors extending the safe operating range of the cooling water system. The project started on March 31, 2006 and ended in August 30, 2010. The project was a multiyear, multi-phase project with laboratory research and development as well as a small pilot-scale field demonstration. In Phase 1 (Technical Targets and Proof of Concept), the objectives were to establish quantitative technical targets and develop calcite and silica scale inhibitor chemistries for high stress conditions. Additional Phase I work included bench-scale testing to determine the feasibility of two membrane separation technologies (electrodialysis ED and electrode-ionization EDI) for scale minimization. In Phase 2 (Technology Development and Integration), the objectives were to develop additional novel scale inhibitor chemistries, develop selected separation processes, and optimize the integration of the technology components at the laboratory scale. Phase 3 (Technology Validation) validated the integrated system's performance with a pilot-scale demonstration. During Phase 1, Initial evaluations of impaired water characteristics focused on produced waters and reclaimed municipal wastewater effluents. Literature and new data were collected and evaluated. Characteristics of produced waters vary significantly from one site to another, whereas reclaimed municipal wastewater effluents have relatively more uniform characteristics. Assessment to date confirmed that calcite and silica

  9. The assessment of the stability of the electronics industry facility in the man-made emergencies with the use of information technology

    Directory of Open Access Journals (Sweden)

    Hancharyk A.V.

    2016-05-01

    Full Text Available The object of study is the enterprise (object of the electronics industry. By industrial object means engineering-technical complex, which includes buildings, structures, power systems, equipment, automated systems, equipment, tools, etc. By the stability of the industrial object we mean ability to produce specified types of products in required quantities in a case of variety of emergency situations, as well as the willingness to self-repairing in if the object proves in the affected area of weak or medium damages. For the stable operation of the facility, in addition to the stability of the object, the security of workers and employees must be ensured, as well as individual and collective protection equipment have to be provided. One of the important indicators for assessing the sustainability of industrial facilities in emergencies is an evaluation of the probability of occurrence of internal and external emergencies and their impact on the operability of the industrial facility. The estimation of probability of occurrence internal and external emergency situation is characterized by a measure of the risk. By the risk means a value which includes both the probability of accidents and damage from them [1]. The development of criteria for evaluating the stability of the object in the man-made disaster is often identified with the risk. The stability of the facility’s operation in the man-made disaster is estimated by the highest acceptable risk. There are the following methods for determining the risk: statistical, model, expert and sociological. Currently, the software «SKEVIA» has been developed, which allows estimating the damage caused by man-made emergencies for a particular industrial facility. Scientific novelty lies in the development of new criteria for sustainable operation of the enterprises of electronic industry. The practical significance lies in the implementation of software «SKEVIA» at the enterprises of electronic

  10. Stabilizing Niger

    DEFF Research Database (Denmark)

    Hahonou, Eric Komlavi

    international intervention in Niger. Their main objective is to secure their own strategic, economic and political interests by strengthening the Nigerien authorities through direct intervention and capacity building activities. For western states reinforcing state security institutions and stabilizing elite...

  11. Combining physico-chemical analysis with a Daphnia magna bioassay to evaluate a recycling technology for drinking water treatment plant waste residuals.

    Science.gov (United States)

    Chen, Ting; Xu, Yongpeng; Zhu, Shijun; Cui, Fuyi

    2015-12-01

    Recycling water treatment plant (WTP) waste residuals is considered to be a feasible method to enhance the efficiency of pollutant removal. This study also evaluated the safety and water quality of a pilot-DWTP waste residuals recycling technology by combining physical-chemistry analysis with a Daphnia magna assay. The water samples taken from each treatment step were extracted and concentrated by XAD-2 resin and were then analyzed for immobilization and enzyme activity with D. magna. The measured parameters, such as the dissolve organic carbon (DOC), UV254 and THM formation potential (THMFPs) of the recycling process, did not obviously increase over 15 days of continuous operation and were even lower than typical values from a conventional process. The extract concentration ranged from 0 to 2 Leq/ml as measured on the 7th and 15th days and the immobilization of D. magna exposed to water treated by the recycling process was nearly equivalent to that of the conventional process. Both the superoxide dismutase (SOD) and the catalase (CAT) activity assay indicated that a lower dose of water extract (0.5, 1, 1.5 Leq/ml) could stimulate the enzyme activity of D. magna, whereas a higher dose (2 Leq/ml at the sampling point C3, R3, R4 ) inhibits the activity. Moreover, the SOD and CAT activity of D. magna with DOC and UV254 showed a strong concentration-effect relationship, where the concentration range of DOC and UV254 were 4.1-16.2 mg/L and 0.071-4.382 cm(-1), respectively. The results showed that there was no statistically significant difference (p>0.05) between the conventional and recycling treatment processes and the toxicity of water samples in the recycling process did not increase during the 15-day continuous recycling trial. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. The economic performance of combined heat and power from biogas produced from manure in Sweden – A comparison of different CHP technologies

    International Nuclear Information System (INIS)

    Lantz, Mikael

    2012-01-01

    Highlights: ► Interest in biogas from manure is increasing rapidly due to its climate benefits. ► Farm-scale production of CHP from manure-based biogas is not profitable in Sweden. ► Minor changes in energy prices or suggested production subsidies will make it profitable. ► Profitability is also affected by efficiency of scale and introduction of thermophilic conditions. -- Abstract: Interest in the generation of biogas from agricultural residues is increasing rapidly due to its climate benefits. In this study, an evaluation of the economic feasibility of various technologies, also on different scales, for the production of combined heat and power from manure-based biogas in Sweden is presented. The overall conclusion is that such production is not profitable under current conditions. Thus, the gap between the calculated biogas production cost and the acceptable cost for break-even must be bridged by, for example, different policy instruments. In general, efficiency of scale favors large-scale plants compared to individual farm-scale ones. However, a large, centralized biogas plant, using manure from numerous farms, is not always more cost efficient than a large, farm-scale plant treating manure from a few neighboring farms. The utilization of the produced heat, electricity prices, and political incentives, all have a significant impact on the economic outcome, whereas the value of the digestate as fertilizer is currently having a minor impact. Utilization of heat is, however, often limited by the lack of local heat sinks, in which case the implementation of a biogas process operating under thermophilic conditions could increase the profitability due to a more efficient utilization of reactor volume by using more process heat. The results from this study could be utilized by policy makers when implementing policy instruments considering biogas production from manure as well as companies involved in production and utilization of biogas.

  13. Utilization of Agricultural Wastes in Stabilization of Landfill Soil

    Directory of Open Access Journals (Sweden)

    Nidzam Rahmat Mohamad

    2014-01-01

    Full Text Available Palm Oil Fuel Ash (POFA and Rice Husk Ash (RHA are local agricultural waste material from Palm Oil Industry and from Paddy Industry in Malaysia. Currently, the disposal of these ashes from a burning process is a problem to both industries, and hence leads to environmental pollution. The main aim of this research was to investigate the potential of utilizing POFA and RHA as sustainable stabilizer material as partial replacement of traditional one which is lime and Portland Cement (PC. Laboratory investigations were carried out to establish the potential utilization of Malaysian Agricultural wastes POFA and RHA in stabilizing Teluk Kapas Landfill soil. Landfill soil on its own and combination with laterite clay soil were stabilized using POFA or RHA either on its own or in combination with Lime or Portland Cement (PC. The traditional stabilizers of lime or Portland Cement (PC were used as controls. Compacted cylinder test specimens were made at typical stabilizer contents and moist cured for up to 60 days prior to testing for compressive and water absorption tests. The results obtained showed that landfill soil combined with laterite clay (50:50 stabilized with 20% RHA:PC (50:50and POFA: PC (50:50 recorded the highest values of compressive strength compared to the other compositions of stabilizers and soils. However, when the amount of POFA and RHA increased in the system the compressive strength values of the samples tends to increase. These results suggest technological, economic as well as environmental advantages of using POFA and RHA and similar industrial by-products to achieve sustainable infrastructure development with near zero industrial waste.

  14. Fiscal 1999 project for research and development of industrial and scientific technologies. Report on the achievements on research and development of a technology to structure accelerated type living organism functions (Unit zone combination technology and the advancement experimental system structuring technology); 1999 nendo kasokugata seibutsu kino kochiku gijutsu no kenkyu kaihatsu seika hokokusho. Tan'i ryoiki kumiawase gijutsu oyobi shinka jikkenkei system kochiku gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    With an aim at structuring an advancement experimental system that can introduce high-level functions efficiently, research was performed on the unit zone combination technology and the advancement experimental system structuring technology. This paper summarizes the achievements in fiscal 1999. In the research of the unit zone combination technology, analysis was made on the structures and functions of barnase mutants replaced with modules and secondary structure units, in order to investigate how much of plasticity is possessed by the amino acid array constituting natural proteins. In addition, establishment was implemented on the random multi-recombination PCR that can link randomly the DNAs having arbitrary arrangement. Furthermore, the STABLE method was developed successfully to put proteins and DNAs coding thereof into direct correspondence. The research on the optimal advancement experimental system structuring technology using model enzymes placed the importance on the mutation generating technology, or the random peptide library fabricating technology. Research was carried out with an intention of structuring a system to discover quickly an optimal method. (NEDO)

  15. Acoustic position finding of partial discharges in transformers. Combination of partial discharge measurement technology with 3D visualization; Akustische Ortung von Teilentladungen in Transformatoren. TE-Messtechnik und 3-D-Visualisierung kombiniert

    Energy Technology Data Exchange (ETDEWEB)

    Kraetge, Alexander; Hoek, Stefan [Omicron Electronics GmbH, Klaus (Austria)

    2013-11-01

    A new measuring system facilitates the detection of partial discharges in transformers by means of the fully synchronous combination of measurement technology for electrical partial discharges with intuitive 3D visualization of the test object. The contribution under consideration describes the application of this system with examples from the measurement practice.

  16. Energy implications of future stabilization of atmospheric CO2 content

    International Nuclear Information System (INIS)

    Hoffert, M.I.; Jain, A.K.

    1998-01-01

    The United Nations Framework Convention on Climate Change calls for ''stabilization of greenhouse-gas concentrations in the atmosphere at a level that would prevent dangerous anthropogenic interference with the climate system...''. A standard baseline scenario that assumes no policy intervention to limit greenhouse-gas emissions has 10 TW (10 x 10 12 watts) of carbon-emission-free power being produced by the year 2050, equivalent to the power provided by all today's energy sources combined. Here we employ a carbon-cycle/energy model to estimate the carbon-emission-free power needed for various atmospheric CO 2 stabilization scenarios. We find that CO 2 stabilization with continued economic growth will require innovative, cost-effective and carbon-emission-free technologies that can provide additional tens of terawatts of primary power in the coming decades, and certainly by the middle of the twenty-first century, even with sustained improvement in the economic productivity of primary energy. (author)

  17. Energy-environment policy modeling of endogenous technological change with personal vehicles. Combining top-down and bottom-up methods

    International Nuclear Information System (INIS)

    Jaccard, Mark; Murphy, Rose; Rivers, Nic

    2004-01-01

    The transportation sector offers substantial potential for greenhouse gas (GHG) emission abatement, but widely divergent cost estimates complicate policy making; energy-economy policy modelers apply top-down and bottom-up cost definitions and different assumptions about future technologies and the preferences of firms and households. Our hybrid energy-economy policy model is technology-rich, like a bottom-up model, but has empirically estimated behavioral parameters for risk and technology preferences, like a top-down model. Unlike typical top-down models, however, it simulates technological change endogenously with functions that relate the financial costs of technologies to cumulative production and adjust technology preferences as market shares change. We apply it to the choice of personal vehicles to indicate, first, the effect on cost estimates of divergent cost definitions and, second, the possible response to policies that require a minimum market share for low emission vehicles

  18. Microencapsulation of Lactobacillus acidophilus NCIMB 701748 in matrices containing soluble fibre by spray drying: Technological characterization, storage stability and survival after in vitro digestion☆

    Science.gov (United States)

    Yonekura, Lina; Sun, Han; Soukoulis, Christos; Fisk, Ian

    2014-01-01

    We evaluated sodium alginate, chitosan and hydroxypropyl methylcellulose (HPMC) as co-encapsulants for spray dried Lactobacillus acidophilus NCIMB 701748 by assessing their impact on cell viability and physicochemical properties of the dried powders, viability over 35 days of storage at 25 °C and survival after simulated digestion. Fibres were added to a control carrier medium containing whey protein concentrate, d-glucose and maltodextrin. Sodium alginate and HPMC did not affect cell viability but chitosan reduced viable counts in spray dried powders, as compared to the control. Although chitosan caused large losses of viability during spray-drying, these losses were counteracted by the excellent storage stability compared to control, sodium alginate and HPMC, and the overall effect became positive after the 35-day storage. Chitosan also improved survival rates in simulated GI conditions, however no single fibre could improve L. acidophilus NCIMB 701748 viability in all steps from production through storage and digestion. PMID:24748900

  19. Introduction and development of soil thermal stabilization technologies at the objects of oil pumping station-2 (OPS-2 of "Kuyumba - Tayshet" trunk oil pipeline

    Directory of Open Access Journals (Sweden)

    Sapsay Aleksey Nikolaevich

    2014-09-01

    Full Text Available The article deals with the questions of designing the foundations for the Oil Pumping Station-2 site of "Kuyumba - Tayshet" trunk oil pipeline. The problems of choice and grounds for technical solutions are considered basing on the results of complex thermotechnical calculations. The construction territory of OPS-2 site of "Kuyumba - Tayshet" trunk oil pipeline is characterized by complex engineering and geocryological conditions: 1 presence of permafrost soil on 80 % of the site area; 2 absence of sufficiently widespread rocky soils under designed buildings and constructions; 3 transition of loamy grounds into yield during thawing. The buildings and facilities are designed on the basis of pile foundation type with high rigid foundation grill. The piles’ diameter is 325 mm and 426 mm, the total length of piles is 9-12 m. The full designed vertical loading, transferred to the pile, is ranging from 10.6 to 50.4 tf. According to the results of the calculations, in order to provide the necessary bearing capacity of piles, securing the perception of transmitted designed loadings, the equivalent temperature of the soil along the side surface of piles ( e should not be higher than -0,5 °C. Taking into account that the soil temperatures on the projected site mainly range from -0.1 to -0.3 °C, in order to lower their temperatures to the calculated values ventilated underground areas are arranged under the buildings and facilities and seasonally active cooling devices (soil thermal stabilizers are installed. Assembly technique and construction of ventilated underground areas with application of soil thermal stabilizers were developed earlier while designing the pipeline system "Zapolyarye - Oil Pumping Station Purpe". For confirmation of the accepted decisions forecasting thermotechnical calculations were performed with the use of a special computer program TermoStab 67-87, which allows simulating the changes of temperature regimes of the permafrost

  20. Die spacer thickness reproduction for central incisor crown fabrication with combined computer-aided design and 3D printing technology: an in vitro study.

    Science.gov (United States)

    Hoang, Lisa N; Thompson, Geoffrey A; Cho, Seok-Hwan; Berzins, David W; Ahn, Kwang Woo

    2015-05-01

    The inability to control die spacer thickness has been reported. However, little information is available on the congruency between the computer-aided design parameters for die spacer thickness and the actual printout. The purpose of this study was to evaluate the accuracy and precision of the die spacer thickness achieved by combining computer-aided design and 3-dimensional printing technology. An ivorine maxillary central incisor was prepared for a ceramic crown. The prepared tooth was duplicated by using polyvinyl siloxane duplicating silicone, and 80 die-stone models were produced from Type IV dental stone. The dies were randomly divided into 5 groups with assigned die spacer thicknesses of 25 μm, 45 μm, 65 μm, 85 μm, and 105 μm (n=16). The printed resin copings, obtained from a printer (ProJet DP 3000; 3D Systems), were cemented onto their respective die-stone models with self-adhesive resin cement and stored at room temperature until sectioning into halves in a buccolingual direction. The internal gap was measured at 5 defined locations per side of the sectioned die. Images of the printed resin coping/die-stone model internal gap dimensions were obtained with an inverted bright field metallurgical microscope at ×100 magnification. The acquired digital image was calibrated, and measurements were made using image analysis software. Mixed models (α=.05) were used to evaluate accuracy. A false discovery rate at 5% was used to adjust for multiple testing. Coefficient of variation was used to determine the precision for each group and was evaluated statistically with the Wald test (α=.05). The accuracy, expressed in terms of the mean differences between the prescribed die spacer thickness and the measured internal gap (standard deviation), was 50 μm (11) for the 25 μm group simulated die spacer thickness, 30 μm (10) for the 45 μm group, 15 μm (14) for the 65 μm group, 3 μm (23) for the 85 μm group, and -10 μm (32) for the 105 μm group. The