Sample records for space radiation imaging

  1. Space Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R.


    This booklet discusses three kinds of space radiation, cosmic rays, Van Allen Belts, and solar plasma. Cosmic rays are penetrating particles that we cannot see, hear or feel, which come from distant stars. Van Allen Belts, named after their discoverer are great belts of protons and electrons that the earth has captured in its magnetic trap. Solar plasma is a gaseous, electrically neutral mixture of positive and negative ions that the sun spews out from convulsed regions on its surface.

  2. The Physics of Imaging with Remote Sensors : Photon State Space & Radiative Transfer (United States)

    Davis, Anthony B.


    Standard (mono-pixel/steady-source) retrieval methodology is reaching its fundamental limit with access to multi-angle/multi-spectral photo- polarimetry. Next... Two emerging new classes of retrieval algorithm worth nurturing: multi-pixel time-domain Wave-radiometry transition regimes, and more... Cross-fertilization with bio-medical imaging. Physics-based remote sensing: - What is "photon state space?" - What is "radiative transfer?" - Is "the end" in sight? Two wide-open frontiers! center dot Examples (with variations.

  3. Radiation effects in space

    Energy Technology Data Exchange (ETDEWEB)

    Fry, R.J.M.


    As more people spend more time in space, and the return to the moon and exploratory missions are considered, the risks require continuing examination. The effects of microgravity and radiation are two potential risks in space. These risks increase with increasing mission duration. This document considers the risk of radiation effects in space workers and explorers. 17 refs., 1 fig., 4 tabs.

  4. Multiscale registration of medical images based on edge preserving scale space with application in image-guided radiation therapy (United States)

    Li, Dengwang; Li, Hongsheng; Wan, Honglin; Chen, Jinhu; Gong, Guanzhong; Wang, Hongjun; Wang, Liming; Yin, Yong


    Mutual information (MI) is a well-accepted similarity measure for image registration in medical systems. However, MI-based registration faces the challenges of high computational complexity and a high likelihood of being trapped into local optima due to an absence of spatial information. In order to solve these problems, multi-scale frameworks can be used to accelerate registration and improve robustness. Traditional Gaussian pyramid representation is one such technique but it suffers from contour diffusion at coarse levels which may lead to unsatisfactory registration results. In this work, a new multi-scale registration framework called edge preserving multiscale registration (EPMR) was proposed based upon an edge preserving total variation L1 norm (TV-L1) scale space representation. TV-L1 scale space is constructed by selecting edges and contours of images according to their size rather than the intensity values of the image features. This ensures more meaningful spatial information with an EPMR framework for MI-based registration. Furthermore, we design an optimal estimation of the TV-L1 parameter in the EPMR framework by training and minimizing the transformation offset between the registered pairs for automated registration in medical systems. We validated our EPMR method on both simulated mono- and multi-modal medical datasets with ground truth and clinical studies from a combined positron emission tomography/computed tomography (PET/CT) scanner. We compared our registration framework with other traditional registration approaches. Our experimental results demonstrated that our method outperformed other methods in terms of the accuracy and robustness for medical images. EPMR can always achieve a small offset value, which is closer to the ground truth both for mono-modality and multi-modality, and the speed can be increased 5-8% for mono-modality and 10-14% for multi-modality registration under the same condition. Furthermore, clinical application by adaptive

  5. NASA Space Radiation Laboratory (United States)

    Federal Laboratory Consortium — The NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory is a NASA funded facility, delivering heavy ion beams to a target area where scientists...

  6. Using the human eye to image space radiation or the history and status of the light flash phenomena (United States)

    Fuglesang, C.


    About 80% of people who travel in space experience sudden phosphenes, commonly called light flashes (LF). Although the detailed physiological process is still not known, the LFs are caused by particles in the cosmic radiation field. Indeed, by counting LFs one can even make a crude image of the radiation environment around the Earth. Studies on the space station Mir with the SilEye experiment correlated LFs with charged particles traversing the eye. It was found that a nucleus in the radiation environment has roughly a 1% probability of causing a light flash, whereas the proton's probability is almost three orders of magnitude less. As a function of linear energy transfer (LET), the probability increased with ionization above 10 keV/μm, reaching about 5% at 50 keV/μm. The investigations are continuing on the International Space Station (ISS) with the Alteino/SileEye-3 detector, which is also a precursor to the large Anomalous Long Term Effects on Astronauts (ALTEA) facility. These detectors are also measuring—imaging—the radiation environment inside the ISS, which will be compared to Geant4 simulations from the DESIRE project. To further the understanding of the LF phenomena, a survey among current NASA and ESA astronauts was recently conducted. The LFs are predominantly noticed before sleep and some respondents even thought it disturbed their sleep. The LFs appear white, have elongated shapes, and most interestingly, often come with a sense of motion. Comparing the shapes quoted from space observations with ground experiments done by researchers in the 1970s, it seems likely that some 5-10% of the LFs in space are due to Cherenkov light in the eye. However, the majority is most likely caused by some direct interaction in the retina.

  7. Workshops on radiation imaging detectors

    Energy Technology Data Exchange (ETDEWEB)

    Sochinskii, N.V.; Sun, G.C.; Kostamo, P.; Silenas, A.; Saynatjoki, A.; Grant, J.; Owens, A.; Kozorezov, A.G.; Noschis, E.; Van Eijk, C.; Nagarkar, V.; Sekiya, H.; Pribat, D.; Campbell, M.; Lundgren, J.; Arques, M.; Gabrielli, A.; Padmore, H.; Maiorino, M.; Volpert, M.; Lebrun, F.; Van der Putten, S.; Pickford, A.; Barnsley, R.; Anton, M.E.G.; Mitschke, M.; Gros d' Aillon, E.; Frojdh, C.; Norlin, B.; Marchal, J.; Quattrocchi, M.; Stohr, U.; Bethke, K.; Bronnimann, C.H.; Pouvesle, J.M.; Hoheisel, M.; Clemens, J.C.; Gallin-Martel, M.L.; Bergamaschi, A.; Redondo-Fernandez, I.; Gal, O.; Kwiatowski, K.; Montesi, M.C.; Smith, K


    This document gathers the transparencies that were presented at the international workshop on radiation imaging detectors. 9 sessions were organized: 1) materials for detectors and detector structure, 2) front end electronics, 3) interconnected technologies, 4) space, fusion applications, 5) the physics of detection, 6) industrial applications, 7) synchrotron radiation, 8) X-ray sources, and 9) medical and other applications.

  8. Fabric space radiators

    Energy Technology Data Exchange (ETDEWEB)

    Antoniak, Z.I.; Krotiuk, W.J.; Webb, B.J.; Prater, J.T.; Bates, J.M.


    Future Air Force space missions will require thermal radiators that both survive in the hostile space environment and stow away for minimal bulk during launch. Advances in all aspects of radiator design, construction, and analysis will be necessary to enable such future missions. Currently, the best means for obtaining high strength along with flexibility is through structures known as fabrics. The development of new materials and bonding techniques has extended the application range of fabrics into areas traditionally dominated by monolithic and/or metallic structures. Given that even current spacecraft heat rejection considerations tend to dominate spacecraft design and mass, the larger and more complex designs of the future face daunting challenges in thermal control. Ceramic fabrics bonded to ultra-thin metal liners (foils) have the potential of achieving radiator performance levels heretofore unattainable, and of readily matching the advances made in other branches of spacecraft design. The research effort documented here indicates that both pumped loops and heat pipes constructed in ceramic fabrics stand to benefit in multiple ways. Flexibility and low mass are the main advantages exhibited by fabric radiators over conventional metal ones. We feel that fabric radiators have intrinsic merits not possessed by any other radiator design and need to be researched further. 26 refs., 16 figs., 17 tabs.

  9. The space radiation environment

    Energy Technology Data Exchange (ETDEWEB)

    Robbins, D.E.


    There are three primary sources of space radiation: galactic cosmic rays (GCR), trapped belt radiation, and solar particle events (SPE). All are composed of ions, the nuclei of atoms. Their energies range from a few MeV u{sup -1} to over a GeV u{sup -1}. These ions can fragment when they interact with spacecraft materials and produce energetic neutrons and ions of lower atomic mass. Absorbed dose rates inside a typical spacecraft (like the Space Shuttle) in a low inclination (28.5 degrees) orbit range between 0.05 and 2 mGy d{sup -1} depending on the altitude and flight inclination (angle of orbit with the equator). The quality factor of radiation in orbit depends on the relative contributions of trapped belt radiation and GCR, and the dose rate varies both with orbital altitude and inclination. The corresponding equivalent dose rate ranges between 0.1 and 4 mSv d{sup -1}. In high inclination orbits, like that of the Mir Space Station and as is planned for the International Space Station, blood-forming organ (BFO) equivalent dose rates as high as 1.5 mSv d{sup -1}. Thus, on a 1 y mission, a crew member could obtain a total dose of 0.55 Sv. Maximum equivalent dose rates measured in high altitude passes through the South Atlantic Anomaly (SAA) were 10 mSv h{sup -1}. For an interplanetary space mission (e.g., to Mars) annual doses from GCR alone range between 150 mSv y{sup -1} at solar maximum and 580 mSv y{sup -1} at solar minimum. Large SPE, like the October 1989 series, are more apt to occur in the years around solar maximum. In free space, such an event could contribute another 300 mSv, assuming that a warning system and safe haven can be effectively used with operational procedures to minimize crew exposures. Thus, the total dose for a 3 y mission to Mars could exceed 2 Sv.

  10. Space Flight Ionizing Radiation Environments (United States)

    Koontz, Steve


    The space-flight ionizing radiation (IR) environment is dominated by very high-kinetic energy-charged particles with relatively smaller contributions from X-rays and gamma rays. The Earth's surface IR environment is not dominated by the natural radioisotope decay processes. Dr. Steven Koontz's lecture will provide a solid foundation in the basic engineering physics of space radiation environments, beginning with the space radiation environment on the International Space Station and moving outward through the Van Allen belts to cislunar space. The benefits and limitations of radiation shielding materials will also be summarized.

  11. Stereo images from space (United States)

    Sabbatini, Massimo; Collon, Maximilien J.; Visentin, Gianfranco


    The Erasmus Recording Binocular (ERB1) was the first fully digital stereo camera used on the International Space Station. One year after its first utilisation, the results and feedback collected with various audiences have convinced us to continue exploiting the outreach potential of such media, with its unique capability to bring space down to earth, to share the feeling of weightlessness and confinement with the viewers on earth. The production of stereo is progressing quickly but it still poses problems for the distribution of the media. The Erasmus Centre of the European Space Agency has experienced how difficult it is to master the full production and distribution chain of a stereo system. Efforts are also on the way to standardize the satellite broadcasting part of the distribution. A new stereo camera is being built, ERB2, to be launched to the International Space Station (ISS) in September 2008: it shall have 720p resolution, it shall be able to transmit its images to the ground in real-time allowing the production of live programs and it could possibly be used also outside the ISS, in support of Extra Vehicular Activities of the astronauts. These new features are quite challenging to achieve in the reduced power and mass budget available to space projects and we hope to inspire more designers to come up with ingenious ideas to built cameras capable to operate in the hash Low Earth Orbit environment: radiations, temperature, power consumption and thermal design are the challenges to be met. The intent of this paper is to share with the readers the experience collected so far in all aspects of the 3D video production chain and to increase awareness on the unique content that we are collecting: nice stereo images from space can be used by all actors in the stereo arena to gain consensus on this powerful media. With respect to last year we shall present the progress made in the following areas: a) the satellite broadcasting live of stereo content to D

  12. Space radiation health program plan (United States)


    The Space Radiation Health Program intends to establish the scientific basis for the radiation protection of humans engaged in the exploration of space, with particular emphasis on the establishment of a firm knowledge base to support cancer risk assessment for future planetary exploration. This document sets forth the technical and management components involved in the implementation of the Space Radiation Health Program, which is a major part of the Life Sciences Division (LSD) effort in the Office of Space Science and Applications (OSSA) at the National Aeronautics and Space Administration (NASA). For the purpose of implementing this program, the Life Sciences Division supports scientific research into the fundamental mechanisms of radiation effects on living systems and the interaction of radiation with cells, tissues, and organs, and the development of instruments and processes for measuring radiation and its effects. The Life Sciences Division supports researchers at universities, NASA field centers, non-profit research institutes and national laboratories; establishes interagency agreements for cooperative use and development of facilities; and conducts a space-based research program using available and future spaceflight vehicles.

  13. Radiation damage in a micron-sized protein crystal studied via reciprocal space mapping and Bragg coherent diffractive imaging

    Directory of Open Access Journals (Sweden)

    H. D. Coughlan


    Full Text Available For laboratory and synchrotron based X-ray sources, radiation damage has posed a significant barrier to obtaining high-resolution structural data from biological macromolecules. The problem is particularly acute for micron-sized crystals where the weaker signal often necessitates the use of higher intensity beams to obtain the relevant data. Here, we employ a combination of techniques, including Bragg coherent diffractive imaging to characterise the radiation induced damage in a micron-sized protein crystal over time. The approach we adopt here could help screen for potential protein crystal candidates for measurement at X-ray free election laser sources.

  14. Radiative transfer on discrete spaces

    CERN Document Server

    Preisendorfer, Rudolph W; Stark, M; Ulam, S


    Pure and Applied Mathematics, Volume 74: Radiative Transfer on Discrete Spaces presents the geometrical structure of natural light fields. This book describes in detail with mathematical precision the radiometric interactions of light-scattering media in terms of a few well established principles.Organized into four parts encompassing 15 chapters, this volume begins with an overview of the derivations of the practical formulas and the arrangement of formulas leading to numerical solution procedures of radiative transfer problems in plane-parallel media. This text then constructs radiative tran

  15. Measuring space radiation shielding effectiveness (United States)

    Bahadori, Amir; Semones, Edward; Ewert, Michael; Broyan, James; Walker, Steven


    Passive radiation shielding is one strategy to mitigate the problem of space radiation exposure. While space vehicles are constructed largely of aluminum, polyethylene has been demonstrated to have superior shielding characteristics for both galactic cosmic rays and solar particle events due to the high hydrogen content. A method to calculate the shielding effectiveness of a material relative to reference material from Bragg peak measurements performed using energetic heavy charged particles is described. Using accelerated alpha particles at the National Aeronautics and Space Administration Space Radiation Laboratory at Brookhaven National Laboratory, the method is applied to sample tiles from the Heat Melt Compactor, which were created by melting material from a simulated astronaut waste stream, consisting of materials such as trash and unconsumed food. The shielding effectiveness calculated from measurements of the Heat Melt Compactor sample tiles is about 10% less than the shielding effectiveness of polyethylene. Shielding material produced from the astronaut waste stream in the form of Heat Melt Compactor tiles is therefore found to be an attractive solution for protection against space radiation.

  16. Measuring space radiation shielding effectiveness

    Directory of Open Access Journals (Sweden)

    Bahadori Amir


    Full Text Available Passive radiation shielding is one strategy to mitigate the problem of space radiation exposure. While space vehicles are constructed largely of aluminum, polyethylene has been demonstrated to have superior shielding characteristics for both galactic cosmic rays and solar particle events due to the high hydrogen content. A method to calculate the shielding effectiveness of a material relative to reference material from Bragg peak measurements performed using energetic heavy charged particles is described. Using accelerated alpha particles at the National Aeronautics and Space Administration Space Radiation Laboratory at Brookhaven National Laboratory, the method is applied to sample tiles from the Heat Melt Compactor, which were created by melting material from a simulated astronaut waste stream, consisting of materials such as trash and unconsumed food. The shielding effectiveness calculated from measurements of the Heat Melt Compactor sample tiles is about 10% less than the shielding effectiveness of polyethylene. Shielding material produced from the astronaut waste stream in the form of Heat Melt Compactor tiles is therefore found to be an attractive solution for protection against space radiation.

  17. Space Radiation Protection, Space Weather, and Exploration (United States)

    Zapp, Neal; Fry, Dan; Lee, Kerry


    Management of crew exposure to radiation is a major concern for manned spaceflight and will be even more important for the modern concept of longer-duration exploration. The inherent protection afforded to astronauts by the magnetic field of the Earth in Low Earth Orbit (LEO) makes operations on the space shuttle or space station very different from operations during a deep space exploration mission. In order to experience significant radiation-derived Loss of Mission (LOM) or Loss of Crew (LOC) risk for LEO operations, one is almost driven to dictate extreme duration or to dictate an extreme sequence of solar activity. Outside of the geo-magnetosphere, however, this scenario changes dramatically. Exposures to the same event on the ISS and on the surface of the Moon may differ by multiple orders of magnitude. This change in magnitude, coupled with the logistical constraints present in implementing any practical operational mitigation make situational awareness with regard to space weather a limiting factor for our ability to conduct exploration operations. With these differences in risk to crew, vehicle and mission in mind, we present the status of the efforts currently underway as the required development to enable exploration operations. The changes in the operating environment as crewed operations begin to stretch away from the Earth are changing the way we think about the lines between research and operations . The real, practical work to enable a permanent human presence away from Earth has already begun

  18. Space radiation protection: Destination Mars (United States)

    Durante, Marco


    National space agencies are planning a human mission to Mars in the XXI century. Space radiation is generally acknowledged as a potential showstopper for this mission for two reasons: a) high uncertainty on the risk of radiation-induced morbidity, and b) lack of simple countermeasures to reduce the exposure. The need for radiation exposure mitigation tools in a mission to Mars is supported by the recent measurements of the radiation field on the Mars Science Laboratory. Shielding is the simplest physical countermeasure, but the current materials provide poor reduction of the dose deposited by high-energy cosmic rays. Accelerator-based tests of new materials can be used to assess additional protection in the spacecraft. Active shielding is very promising, but as yet not applicable in practical cases. Several studies are developing technologies based on superconducting magnetic fields in space. Reducing the transit time to Mars is arguably the best solution but novel nuclear thermal-electric propulsion systems also seem to be far from practical realization. It is likely that the first mission to Mars will employ a combination of these options to reduce radiation exposure.

  19. Mitigation of Space Radiation Effects (United States)

    Atwell, William


    During low earth orbit and deep space missions, humans and spacecraft systems are exposed to high energy particles emanating from basically three sources: geomagnetically-trapped protons and electrons (Van Allen Belts), extremely high energy galactic cosmic radiation (GCR), and solar proton events (SPEs). The particles can have deleterious effects if not properly shielded. For humans, there can be a multitude of harmful effects depending on the degree of exposure. For spacecraft systems, especially electronics, the effects can range from single event upsets (SEUs) to catastrophic effects such as latchup and burnout. In addition, some materials, radio-sensitive experiments, and scientific payloads are subject to harmful effects. To date, other methods have been proposed such as electrostatic and electromagnetic shielding, but these approaches have not proven feasible due to cost, weight, and safety issues. The only method that has merit and has been effective is bulk or parasitic shielding. In this paper, we discuss in detail the sources of the space radiation environment, spacecraft, human, and onboard systems modeling methodologies, transport of these particles through shielding materials, and the calculation of the dose effects. In addition, a review of the space missions to date and a discussion of the space radiation mitigation challenges for lunar and deep space missions such as lunar outposts and human missions to Mars are presented.

  20. k-space sampling optimization for ultrashort TE imaging of cortical bone: Applications in radiation therapy planning and MR-based PET attenuation correction

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Lingzhi, E-mail:, E-mail:; Traughber, Melanie [Philips Healthcare, Cleveland, Ohio 44143 (United States); Su, Kuan-Hao; Pereira, Gisele C.; Grover, Anu; Traughber, Bryan; Muzic, Raymond F. Jr., E-mail:, E-mail: [University Hospitals Case Medical Center, Cleveland, Ohio 44106 (United States)


    Purpose: The ultrashort echo-time (UTE) sequence is a promising MR pulse sequence for imaging cortical bone which is otherwise difficult to image using conventional MR sequences and also poses strong attenuation for photons in radiation therapy and PET imaging. The authors report here a systematic characterization of cortical bone signal decay and a scanning time optimization strategy for the UTE sequence through k-space undersampling, which can result in up to a 75% reduction in acquisition time. Using the undersampled UTE imaging sequence, the authors also attempted to quantitatively investigate the MR properties of cortical bone in healthy volunteers, thus demonstrating the feasibility of using such a technique for generating bone-enhanced images which can be used for radiation therapy planning and attenuation correction with PET/MR. Methods: An angularly undersampled, radially encoded UTE sequence was used for scanning the brains of healthy volunteers. Quantitative MR characterization of tissue properties, including water fraction and R2{sup ∗} = 1/T2{sup ∗}, was performed by analyzing the UTE images acquired at multiple echo times. The impact of different sampling rates was evaluated through systematic comparison of the MR image quality, bone-enhanced image quality, image noise, water fraction, and R2{sup ∗} of cortical bone. Results: A reduced angular sampling rate of the UTE trajectory achieves acquisition durations in proportion to the sampling rate and in as short as 25% of the time required for full sampling using a standard Cartesian acquisition, while preserving unique MR contrast within the skull at the cost of a minimal increase in noise level. The R2{sup ∗} of human skull was measured as 0.2–0.3 ms{sup −1} depending on the specific region, which is more than ten times greater than the R2{sup ∗} of soft tissue. The water fraction in human skull was measured to be 60%–80%, which is significantly less than the >90% water fraction in

  1. Scattered Radiation Emission Imaging: Principles and Applications

    Directory of Open Access Journals (Sweden)

    M. K. Nguyen


    Full Text Available Imaging processes built on the Compton scattering effect have been under continuing investigation since it was first suggested in the 50s. However, despite many innovative contributions, there are still formidable theoretical and technical challenges to overcome. In this paper, we review the state-of-the-art principles of the so-called scattered radiation emission imaging. Basically, it consists of using the cleverly collected scattered radiation from a radiating object to reconstruct its inner structure. Image formation is based on the mathematical concept of compounded conical projection. It entails a Radon transform defined on circular cone surfaces in order to express the scattered radiation flux density on a detecting pixel. We discuss in particular invertible cases of such conical Radon transforms which form a mathematical basis for image reconstruction methods. Numerical simulations performed in two and three space dimensions speak in favor of the viability of this imaging principle and its potential applications in various fields.

  2. Biology relevant to space radiation

    Energy Technology Data Exchange (ETDEWEB)

    Fry, R.J.M. [Oak Ridge National Lab., TN (United States)


    There are only very limited data on the health effects to humans from the two major components of the radiations in space, namely protons and heavy ions. As a result, predictions of the accompanying effects must be based either on (1) data generated through studies of experimental systems exposed on earth at rates and fluences higher than those in space, or (2) extrapolations from studies of gamma and x rays. Better information is needed about the doses, dose rates, and the energy and LET spectra of the radiations at the organ level that are anticipated to be encountered during extended space missions. In particular, there is a need for better estimates of the relationship between radiation quality and biological effects. In the case of deterministic effects, it is the threshold that is important. The possibility of the occurrence of a large solar particle event (SPE) requires that such effects be considered during extended space missions. Analyses suggest, however, that it is feasible to provide sufficient shielding so as to reduce such effects to acceptable levels, particularly if the dose rates can be limited. If these analyses prove correct, the primary biological risks will be the stochastic effects (latent cancer induction). The contribution of one large SPE to the risk of stochastic effects while undesirable will not be large in comparison to the potential total dose on a mission of long duration.

  3. Space radiator simulation system analysis (United States)

    Black, W. Z.; Wulff, W.


    A transient heat transfer analysis was carried out on a space radiator heat rejection system exposed to an arbitrarily prescribed combination of aerodynamic heating, solar, albedo, and planetary radiation. A rigorous analysis was carried out for the radiation panel and tubes lying in one plane and an approximate analysis was used to extend the rigorous analysis to the case of a curved panel. The analysis permits the consideration of both gaseous and liquid coolant fluids, including liquid metals, under prescribed, time dependent inlet conditions. The analysis provided a method for predicting: (1) transient and steady-state, two dimensional temperature profiles, (2) local and total heat rejection rates, (3) coolant flow pressure in the flow channel, and (4) total system weight and protection layer thickness.

  4. Miniature Active Space Radiation Dosimeter Project (United States)

    National Aeronautics and Space Administration — Space Micro will extend our Phase I R&D to develop a family of miniature, active space radiation dosimeters/particle counters, with a focus on biological/manned...

  5. Advanced Space Radiation Detector Technology Development (United States)

    Wrbanek, John D.; Wrbanek, Susan Y.; Fralick, Gustave C.


    The advanced space radiation detector development team at the NASA Glenn Research Center (GRC) has the goal of developing unique, more compact radiation detectors that provide improved real-time data on space radiation. The team has performed studies of different detector designs using a variety of combinations of solid-state detectors, which allow higher sensitivity to radiation in a smaller package and operate at lower voltage than traditional detectors. Integration of multiple solid-state detectors will result in an improved detector system in comparison to existing state-of-the-art instruments for the detection and monitoring of the space radiation field for deep space and aerospace applications.

  6. The NASA Space Radiation Health Program (United States)

    Schimmerling, W.; Sulzman, F. M.


    The NASA Space Radiation Health Program is a part of the Life Sciences Division in the Office of Space Science and Applications (OSSA). The goal of the Space Radiation Health Program is development of scientific bases for assuring adequate radiation protection in space. A proposed research program will determine long-term health risks from exposure to cosmic rays and other radiation. Ground-based animal models will be used to predict risk of exposures at varying levels from various sources and the safe levels for manned space flight.

  7. Space Radiation Transport Methods Development (United States)

    Wilson, J. W.; Tripathi, R. K.; Qualls, G. D.; Cucinotta, F. A.; Prael, R. E.; Norbury, J. W.; Heinbockel, J. H.; Tweed, J.


    Improved spacecraft shield design requires early entry of radiation constraints into the design process to maximize performance and minimize costs. As a result, we have been investigating high-speed computational procedures to allow shield analysis from the preliminary design concepts to the final design. In particular, we will discuss the progress towards a full three-dimensional and computationally efficient deterministic code for which the current HZETRN evaluates the lowest order asymptotic term. HZETRN is the first deterministic solution to the Boltzmann equation allowing field mapping within the International Space Station (ISS) in tens of minutes using standard Finite Element Method (FEM) geometry common to engineering design practice enabling development of integrated multidisciplinary design optimization methods. A single ray trace in ISS FEM geometry requires 14 milliseconds and severely limits application of Monte Carlo methods to such engineering models. A potential means of improving the Monte Carlo efficiency in coupling to spacecraft geometry is given in terms of reconfigurable computing and could be utilized in the final design as verification of the deterministic method optimized design.

  8. Modeling Space Radiation with Radiomimetic Agent Bleomycin (United States)

    Lu, Tao


    Space radiation consists of proton and helium from solar particle events (SPE) and high energy heavy ions from galactic cosmic ray (GCR). This mixture of radiation with particles at different energy levels has different effects on biological systems. Currently, majority studies of radiation effects on human were based on single-source radiation due to the limitation of available method to model effects of space radiation on living organisms. While NASA Space Radiation Laboratory is working on advanced switches to make it possible to have a mixed field radiation with particles of different energies, the radiation source will be limited. Development of an easily available experimental model for studying effects of mixed field radiation could greatly speed up our progress in our understanding the molecular mechanisms of damage and responses from exposure to space radiation, and facilitate the discovery of protection and countermeasures against space radiation, which is critical for the mission to Mars. Bleomycin, a radiomimetic agent, has been widely used to study radiation induced DNA damage and cellular responses. Previously, bleomycin was often compared to low low Linear Energy Transfer (LET) gamma radiation without defined characteristics. Our recent work demonstrated that bleomycin could induce complex clustered DNA damage in human fibroblasts that is similar to DNA damage induced by high LET radiation. These type of DNA damage is difficult to repair and can be visualized by gamma-H2Ax staining weeks after the initial insult. The survival ratio between early and late plating of human fibroblasts after bleomycin treatment is between low LET and high LET radiation. Our results suggest that bleomycin induces DNA damage and other cellular stresses resembling those resulted from mixed field radiation with both low and high LET particles. We hypothesize that bleomycin could be used to mimic space radiation in biological systems. Potential advantages and limitations of

  9. Space-Time Quantum Imaging

    Directory of Open Access Journals (Sweden)

    Ronald E. Meyers


    Full Text Available We report on an experimental and theoretical investigation of quantum imaging where the images are stored in both space and time. Ghost images of remote objects are produced with either one or two beams of chaotic laser light generated by a rotating ground glass and two sensors measuring the reference field and bucket field at different space-time points. We further observe that the ghost images translate depending on the time delay between the sensor measurements. The ghost imaging experiments are performed both with and without turbulence. A discussion of the physics of the space-time imaging is presented in terms of quantum nonlocal two-photon analysis to support the experimental results. The theoretical model includes certain phase factors of the rotating ground glass. These experiments demonstrated a means to investigate the time and space aspects of ghost imaging and showed that ghost imaging contains more information per measured photon than was previously recognized where multiple ghost images are stored within the same ghost imaging data sets. This suggests new pathways to explore quantum information stored not only in multi-photon coincidence information but also in time delayed multi-photon interference. The research is applicable to making enhanced space-time quantum images and videos of moving objects where the images are stored in both space and time.

  10. Rotary radiators for reduced space powerplant temperatures (United States)

    Elliott, D. G.

    If new radiator concepts can achieve radiator weights below 3 kg/sq m, nuclear space powerplants can operate at temperatures below 900 K and use stainless steel construction. Tube-and-fin or heat-pipe radiators weigh at least 5 kg/sq m because the tube walls must be thick enough to prevent or limit meteoroid punctures. However, radiators that require no meteoroid protection can be built using low-vapor-pressure liquids that can be exposed directly to space. One possible design for such a radiator is the 'rotary radiator' that uses centrifugal force to move the liquid across a thin radiating disk and uses surface tension to retain the liquid despite meteoroid punctures.

  11. Space Radiation and its Associated Health Consequences (United States)

    Wu, Honglu


    During space travel, astronauts are exposed to energetic particles of a complex composition and energy distribution. For the same amount of absorbed dose, these particles can be much more effective than X- or gamma rays in the induction of biological effects, including cell inactivation, genetic mutations, cataracts, and cancer induction. Several of the biological consequences of space radiation exposure have already been observed in astronauts. This presentation will introduce the space radiation environment and discuss its associated health risks. Accurate assessment of the radiation risks and development of respective countermeasures are essential for the success of future exploration missions to the Moon and Mars.

  12. Potential health effects of space radiation (United States)

    Yang, Chui-Hsu; Craise, Laurie M.


    Crewmembers on missions to the Moon or Mars will be exposed to radiation belts, galactic cosmic rays, and possibly solar particle events. The potential health hazards due to these space radiations must be considered carefully to ensure the success of space exploration. Because there is no human radioepidemiological data for acute and late effects of high-LET (Linear-Energy-Transfer) radiation, the biological risks of energetic charged particles have to be estimated from experimental results on animals and cultured cells. Experimental data obtained to date indicate that charged particle radiation can be much more effective than photons in causing chromosome aberrations, cell killing, mutation, and tumor induction. The relative biological effectiveness (RBE) varies with biological endpoints and depends on the LET of heavy ions. Most lesions induced by low-LET radiation can be repaired in mammalian cells. Energetic heavy ions, however, can produce large complex DNA damages, which may lead to large deletions and are irreparable. For high-LET radiation, therefore, there are less or no dose rate effects. Physical shielding may not be effective in minimizing the biological effects on energetic heavy ions, since fragments of the primary particles can be effective in causing biological effects. At present the uncertainty of biological effects of heavy particles is still very large. With further understanding of the biological effects of space radiation, the career doses can be kept at acceptable levels so that the space radiation environment need not be a barrier to the exploitation of the promise of space.

  13. Radiation Hardness Assurance for Space Systems (United States)

    Poivey, Christian; Day, John H. (Technical Monitor)


    The space radiation environment can lead to extremely harsh operating conditions for on-board electronic box and systems. The characteristics of the radiation environment are highly dependent on the type of mission (date, duration and orbit). Radiation accelerates the aging of the electronic parts and material and can lead to a degradation of electrical performance; it can also create transient phenomena on parts. Such damage at the part level can induce damage or functional failure at electronic box, subsystem, and system levels. A rigorous methodology is needed to ensure that the radiation environment does not compromise the functionality and performance of the electronics during the system life. This methodology is called hardness assurance. It consists of those activities undertaken to ensure that the electronic piece parts placed in the space system perform to their design specifications after exposure to the space environment. It deals with system requirements, environmental definitions, part selection, part testing, shielding and radiation tolerant design. All these elements should play together in order to produce a system tolerant to.the radiation environment. An overview of the different steps of a space system hardness assurance program is given in section 2. In order to define the mission radiation specifications and compare these requirements to radiation test data, a detailed knowledge of the space environment and the corresponding electronic device failure mechanisms is required. The presentation by J. Mazur deals with the Earth space radiation environment as well as the internal environment of a spacecraft. The presentation by J. Schwank deals with ionization effects, and the presentation by T. Weatherford deals with Single particle Event Phenomena (SEP) in semiconductor devices and microcircuits. These three presentations provide more detailed background to complement the sections 3 and 4. Part selection and categorization are discussed in section

  14. Simple Benchmark Specifications for Space Radiation Protection (United States)

    Singleterry, Robert C. Jr.; Aghara, Sukesh K.


    This report defines space radiation benchmark specifications. This specification starts with simple, monoenergetic, mono-directional particles on slabs and progresses to human models in spacecraft. This report specifies the models and sources needed to what the team performing the benchmark needs to produce in a report. Also included are brief descriptions of how OLTARIS, the NASA Langley website for space radiation analysis, performs its analysis.

  15. Space Radiation and Risks to Human Health (United States)

    Huff, Janice L.


    The radiation environment in space poses significant challenges to human health and is a major concern for long duration manned space missions. Outside the Earth's protective magnetosphere, astronauts are exposed to higher levels of galactic cosmic rays, whose physical characteristics are distinct from terrestrial sources of radiation such as x-rays and gamma-rays. Galactic cosmic rays consist of high energy and high mass nuclei as well as high energy protons; they impart unique biological damage as they traverse through tissue with impacts on human health that are largely unknown. The major health issues of concern are the risks of radiation carcinogenesis, acute and late decrements to the central nervous system, degenerative tissue effects such as cardiovascular disease, as well as possible acute radiation syndromes due to an unshielded exposure to a large solar particle event. The NASA Human Research Program's Space Radiation Program Element is focused on characterization and mitigation of these space radiation health risks along with understanding these risks in context of the other biological stressors found in the space environment. In this overview, we will provide a description of these health risks and the Element's research strategies to understand and mitigate these risks.

  16. Radiation protection guidelines for space missions

    Energy Technology Data Exchange (ETDEWEB)

    Fry, R.J.M.


    The original recommendations for radiation protection guidelines were made by the National Academy of Sciences in 1970. Since that time the US crews have become more diverse in their makeup and much has been learned about both radiation-induced cancer and other late effects. While far from adequate there is now some understanding of the risks that high-Z and -energy (HZE) particles pose. For these reasons it was time to reconsider the radiation protection guidelines for space workers. This task was undertaken recently by National Council on Radiation Protection (NCRP). 42 refs., 2 figs., 9 tabs.

  17. Biological countermeasures in space radiation health (United States)

    Kennedy, Ann R.; Todd, Paul


    Exposure to the types of ionizing radiation encountered during space travel may cause a number of health-related problems, but the primary concern is related to the increased risk of cancer induction in astronauts. The major types of radiation considered to be of importance during space travel are protons and particles of high atomic number and high energy (HZE particles). It is now clear that biological countermeasures can be used to prevent or reduce the levels of biological consequences resulting from exposure to protons or HZE particles, including the induction of cancer, immunosuppression and neurological defects caused by these types of ionizing radiation. Research related to the dietary additions of agents to minimize the risks of developing health-related problems which can result from exposure to space radiations is reviewed.

  18. Biosentinel: Developing a Space Radiation Biosensor (United States)

    Santa Maria, Sergio R.; Marina, Diana B.; Parra, Macarena P.; Boone, Travis D.; Tan, Ming; Ricco, Antonio J.; Straume, Tore N.; Lusby, Terry C.; Harkness, T.; Reiss-Bubenheim, Debra; hide


    Ionizing radiation presents a major challenge to human exploration and long-term residence in space. The deep-space radiation spectrum includes highly energetic particles that generate double strand breaks (DSBs), deleterious DNA lesions that are usually repaired without errors via homologous recombination (HR), a conserved pathway in all eukaryotes. While progress identifying and characterizing biological radiation effects using Earth-based facilities has been significant, no terrestrial source duplicates the unique space radiation environment.We are developing a biosensor-based nanosatellite to fly aboard NASAs Space Launch System Exploration Mission 1, expected to launch in 2017 and reach a 1AU (astronomic unit) heliocentric orbit. Our biosensor (called BioSentinel) uses the yeast S. cerevisiae to measure DSBs in response to ambient space radiation. The BioSentinel strain contains engineered genetic defects that prevent growth until and unless a radiation-induced DSB near a reporter gene activates the yeasts HR repair mechanisms. Thus, culture growth and metabolic activity directly indicate a successful DSB-and-repair event. In parallel, HR-defective and wild type strains will provide survival data. Desiccated cells will be carried within independent culture microwells, built into 96-well microfluidic cards. Each microwell set will be activated by media addition at different time points over 18 months, and cell growth will be tracked continuously via optical density. One reserve set will be activated only in the occurrence of a solar particle event. Biological measurements will be compared to data provided by onboard physical dosimeters and to Earth-based experiments.BioSentinel will conduct the first study of biological response to space radiation outside Low Earth Orbit in over 40 years. BioSentinel will thus address strategic knowledge gaps related to the biological effects of space radiation and will provide an adaptable platform to perform human

  19. Uncertainty Analysis in Space Radiation Protection (United States)

    Cucinotta, Francis A.


    Space radiation is comprised of high energy and charge (HZE) nuclei, protons, and secondary radiation including neutrons. The uncertainties in estimating the health risks from galactic cosmic rays (GCR) are a major limitation to the length of space missions, the evaluation of potential risk mitigation approaches, and application of the As Low As Reasonably Achievable (ALARA) principle. For long duration space missio ns, risks may approach radiation exposure limits, therefore the uncertainties in risk projections become a major safety concern and methodologies used for ground-based works are not deemed to be sufficient. NASA limits astronaut exposures to a 3% risk of exposure induced death (REID) and protects against uncertainties in risks projections using an assessment of 95% confidence intervals in the projection model. We discuss NASA s approach to space radiation uncertainty assessments and applications for the International Space Station (ISS) program and design studies of future missions to Mars and other destinations. Several features of NASA s approach will be discussed. Radiation quality descriptions are based on the properties of radiation tracks rather than LET with probability distribution functions (PDF) for uncertainties derived from radiobiology experiments at particle accelerators. The application of age and gender specific models for individual astronauts is described. Because more than 90% of astronauts are never-smokers, an alternative risk calculation for never-smokers is used and will be compared to estimates for an average U.S. population. Because of the high energies of the GCR limits the benefits of shielding and the limited role expected for pharmaceutical countermeasures, uncertainty reduction continues to be the optimal approach to improve radiation safety for space missions.

  20. Radiation Effects in the Space Telecommunications Environment

    Energy Technology Data Exchange (ETDEWEB)

    Fleetwood, Daniel M.; Winokur, Peter S.


    Trapped protons and electrons in the Earth's radiation belts and cosmic rays present significant challenges for electronics that must operate reliably in the natural space environment. Single event effects (SEE) can lead to sudden device or system failure, and total dose effects can reduce the lifetime of a telecommmiications system with significant space assets. One of the greatest sources of uncertainty in developing radiation requirements for a space system is accounting for the small but finite probability that the system will be exposed to a massive solar particle event. Once specifications are decided, standard laboratory tests are available to predict the total dose response of MOS and bipolar components in space, but SEE testing of components can be more challenging. Prospects are discussed for device modeling and for the use of standard commercial electronics in space.

  1. Radiation shielding for future space exploration missions (United States)

    DeWitt, Joel Michael

    Scope and Method of Study. The risk to space crew health and safety posed by exposure to space radiation is regarded as a significant obstacle to future human space exploration. To countermand this risk, engineers and designers in today's aerospace community will require detailed knowledge of a broad range of possible materials suitable for the construction of future spacecraft or planetary surface habitats that provide adequate protection from a harmful space radiation environment. This knowledge base can be supplied by developing an experimental method that provides quantitative information about a candidate material's space radiation shielding efficacy with the understanding that (1) shielding is currently the only practical countermeasure to mitigate the effects of space radiation on human interplanetary missions, (2) any mass of a spacecraft or planetary surface habitat necessarily alters the incident flux of ionizing radiation on it, and (3) the delivery of mass into LEO and beyond is expensive and therefore may benefit from the possible use of novel multifunctional materials that could in principle reduce cost as well as ionizing radiation exposure. The developed method has an experimental component using CR-39 PNTD and Al2O3:C OSLD that exposes candidate space radiation shielding materials of varying composition and depth to a representative sample of the GCR spectrum that includes 1 GeV 1H and 1 GeV/n 16O, 28Si, and 56Fe heavy ion beams at the BNL NSRL. The computer modeling component of the method used the Monte Carlo radiation transport code FLUKA to account for secondary neutrons that were not easily measured in the laboratory. Findings and Conclusions. This study developed a method that quantifies the efficacy of a candidate space radiation shielding material relative to the standard of polyethylene using a combination of experimental and computer modeling techniques. The study used established radiation dosimetry techniques to present an empirical

  2. Space radiation health research, 1991-1992 (United States)

    Jablin, M. H. (Compiler); Brooks, C. (Compiler); Ferraro, G. (Compiler); Dickson, K. J. (Compiler); Powers, J. V. (Compiler); Wallace-Robinson, J. (Compiler); Zafren, B. (Compiler)


    The present volume is a collection of 227 abstracts of radiation research sponsored by the NASA Space Radiation Health Program for the period 1991-1992. Each abstract has been categorized within one of three discipline areas: Physics, Biology and Risk Assessment. Topic areas within each discipline have been assigned as follows: Physics - Atomic Physics, Theory, Cosmic Ray and Astrophysics, Experimental, Environments and Environmental Models, Solar Activity and Prediction, Experiments, Radiation Transport and Shielding, Theory and Model Development, Experimental Studies, and Instrumentation. Biology - Biology, Molecular Biology, Cellular Radiation Biology, Transformation, Mutation, Lethality, Survival, DNA Damage and Repair, Tissue, Organs, and Organisms, In Vivo/In Vitro Systems, Carcinogenesis and Life Shortening, Cataractogenesis, Genetics/Developmental, Radioprotectants, Plants, and Other Effects. Risk Assessment - Risk Assessment, Radiation Health and Epidemiology, Space Flight Radiation Health Physics, Inter- and Intraspecies Extrapolation and Radiation Limits and Standards. Section I contains refereed journals; Section II contains reports/meetings. Keywords and author indices are provided. A collection of abstracts spanning the period 1986-1990 was previously issued as NASA Technical Memorandum 4270.

  3. Enabling Radiation Tolerant Systems for Space (United States)

    Kauffman, Billy; Hardage, Donna


    A hazard to all spacecraft orbiting the Earth is the existence of a harsh environment with its subsequent effects. The effects can provide damaging or even disabling effects on spacecraft and its instruments. One of the most recognized and serious of the different space environments is ionizing radiation and its effects on spacecraft and spacecraft systems. This is increasingly becoming more of an issue for all missions due to the use of lighter composite materials, smaller satellites, and smaller electronics. NASA's Space Environments and Effects (SEE) Program was established to develop new plateaus of technical capability to reduce the cost of NASA's missions and provide leading-edge exploratory and focused technology to promote continued U.S. preeminence in space. The SEE Program has an "Implementation Plan" to develop roadmaps and fund technical tasks to enable radiation systems for space.

  4. Radiation survey in the International Space Station

    Directory of Open Access Journals (Sweden)

    Narici Livio


    Full Text Available The project ALTEA-shield/survey is part of an European Space Agency (ESA – ILSRA (International Life Science Research Announcement program and provides a detailed study of the International Space Station (ISS (USLab and partly Columbus radiation environment. The experiment spans over 2 years, from September 20, 2010 to September 30, 2012, for a total of about 1.5 years of effective measurements. The ALTEA detector system measures all heavy ions above helium and, to a limited extent, hydrogen and helium (respectively, in 25 Mev–45 MeV and 25 MeV/n–250 MeV/n energy windows while tracking every individual particle. It measures independently the radiation along the three ISS coordinate axes. The data presented consist of flux, dose, and dose equivalent over the time of investigation, at the different surveyed locations. Data are selected from the different geographic regions (low and high latitudes and South Atlantic Anomaly, SAA. Even with a limited acceptance window for the proton contribution, the flux/dose/dose equivalent results as well as the radiation spectra provide information on how the radiation risks change in the different surveyed sites. The large changes in radiation environment found among the measured sites, due to the different shield/mass distribution, require a detailed Computer-Aided Design (CAD model to be used together with these measurements for the validation of radiation models in space habitats. Altitude also affects measured radiation, especially in the SAA. In the period of measurements, the altitude (averaged over each minute ranged from 339 km to 447 km. Measurements show the significant shielding effect of the ISS truss, responsible for a consistent amount of reduction in dose equivalent (and so in radiation quality. Measured Galactic Cosmic Ray (GCR dose rates at high latitude range from 0.354 ± 0.002 nGy/s to 0.770 ± 0.006 nGy/s while dose equivalent from 1.21 ± 0.04 nSv/s to 6.05 ± 0

  5. Space Radiation Program Element Tissue Sharing Forum (United States)

    Wu, H.; Mayeaux, B M.; Huff, J. L.; Simonsen, L. C.


    Over the years, a large number of animal experiments have been conducted at the NASA Space Radiation Laboratory and other facilities under the support of the NASA Space Radiation Program Element (SRPE). Studies using rodents and other animal species to address the space radiation risks will remain a significant portion of the research portfolio of the Element. In order to maximize scientific return of the animal studies, the SRPE has recently released the Space Radiation Tissue Sharing Forum. The Forum provides access to an inventory of investigator-stored tissue samples and enables both NASA SRPE members and NASA-funded investigators to exchange information regarding stored and future radiobiological tissues available for sharing. Registered users may review online data of available tissues, inquire about tissues posted, or request tissues for an upcoming study using an online form. Investigators who have upcoming sacrifices are also encouraged to post the availability of samples using the discussion forum. A brief demo of the forum will be given during the presentation

  6. Radiation of superluminal sources in empty space

    Energy Technology Data Exchange (ETDEWEB)

    Bolotovskii, Boris M; Serov, Alexander V [P.N. Lebedev Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)


    We consider the theoretical prerequisites for and experimental papers on the coherent radiation of electromagnetic waves by moving sources whose speed exceeds the speed of light in empty space. Examples of this kind are provided by a light spot or a charged filament incident on an interface between two media. (reviews of topical problems)

  7. Radiation Risk Projections for Space Travel (United States)

    Cucinotta, Francis


    Space travelers are exposed to solar and galactic cosmic rays comprised of protons and heavy ions moving with velocities close to the speed of light. Cosmic ray heavy ions are known to produce more severe types of biomolecular damage in comparison to terrestrial forms of radiation, however the relationship between such damage and disease has not been fully elucidated. On Earth, we are protected from cosmic rays by atmospheric and magnetic shielding, and only the remnants of cosmic rays in the form of ground level muons and other secondary radiations are present. Because human epidemiology data is lacking for cosmic rays, risk projection must rely on theoretical understanding and data from experimental models exposed to space radiation using charged particle accelerators to simulate space radiation. Although the risks of cancer and other late effects from cosmic rays are currently believed to present a severe challenge to space travel, this challenge is centered on our lack of confidence in risk projections methodologies. We review biophysics and radiobiology data on the effects of the cosmic ray heavy ions, and the current methods used to project radiation risks . Cancer risk projections are described as a product of many biological and physical factors, each of which has a differential range of uncertainty due to lack of data and knowledge. Risk projections for space travel are described using Monte-Carlo sampling from subjective error di stributions that represent the lack of knowledge in each factor that contributes to the projection model in order to quantify the overall uncertainty in risk projections. This analysis is applied to space mi ssion scenarios including lunar colony, deep space outpost, and a Mars mission. Results suggest that the number of days in space where cancer mortality risks can be assured at a 95% confidence level to be below the maximum acceptable risk for radi ation workers on Earth or the International Space Station is only on the order

  8. 2015 Space Radiation Standing Review Panel (United States)

    Steinberg, Susan


    The 2015 Space Radiation Standing Review Panel (from here on referred to as the SRP) met for a site visit in Houston, TX on December 8 - 9, 2015. The SRP met with representatives from the Space Radiation Element and members of the Human Research Program (HRP) to review the updated research plan for the Risk of Radiation Carcinogenesis Cancer Risk. The SRP also reviewed the newly revised Evidence Reports for the Risk of Acute Radiation Syndromes Due to Solar Particle Events (SPEs) (Acute Risk), the Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure (CNS Risk), and the Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation (Degen Risk), as well as a status update on these Risks. The SRP would like to commend Dr. Simonsen, Dr. Huff, Dr. Nelson, and Dr. Patel for their detailed presentations. The Space Radiation Element did a great job presenting a very large volume of material. The SRP considers it to be a strong program that is well-organized, well-coordinated and generates valuable data. The SRP commended the tissue sharing protocols, working groups, systems biology analysis, and standardization of models. In several of the discussed areas the SRP suggested improvements of the research plans in the future. These include the following: It is important that the team has expanded efforts examining immunology and inflammation as important components of the space radiation biological response. This is an overarching and important focus that is likely to apply to all aspects of the program including acute, CVD, CNS, cancer and others. Given that the area of immunology/inflammation is highly complex (and especially so as it relates to radiation), it warrants the expansion of investigators expertise in immunology and inflammation to work with the individual research projects and also the NASA Specialized Center of Research (NSCORs). Historical data on radiation injury to be entered into the Watson

  9. Thermal Radiator Pointing for International Space Station (United States)

    Green, Scott


    In order to provide thermal radiation environments that result in adequate beat rejection, the single-phase, liquid ammonia (NH3) heat rejection system on the International Space Station (ISS) requires that its two thermal radiator wings be dynamically rotated as the ISS travels through its orbit. This paper discusses the closed-loop, thermal radiator pointing system that is used on ISS to ensure adequate heat rejection by the radiators, while preventing freezing of the ammonia under low heat loads and cold-environmental conditions. Although initial designs used an open-loop approach for radiator pointing, concerns about performance robustness, algorithm complexity, memory requirements, and sustaining support drove the development of a more robust, simpler, closed-loop system. Hence, the challenge of the closed-loop system was to utilize existing sensors, actuators and computers to fit into the existing hardware and software architecture of the ISS. Using a proportional-integral (PI) control architecture with limited output and an anti-windup integrator, the temperature of the ammonia coming out of the radiator is measured and controlled by adjusting the radiator wing orientation. The radiator wing orientation for the local minimum environment is fed forward to the control system, and the closed-loop controller is used to generate a bias off of that local minimum environment in order to heat up the ammonia when necessary to avoid freezing. In the earth's shadow, the controller is suspended and the radiator wing is oriented to face the earth, the local maximum thermal environment which further prevents freezing of the ammonia. This control architecture is shown to provide adequate heat rejection and avoid freezing of the ammonia, even though the physical system consists of large transport delays and time-varying dynamics which change dramatically due to orbit motion and variable heat loads.

  10. Laser-plasma-based Space Radiation Reproduction in the Laboratory. (United States)

    Hidding, B; Karger, O; Königstein, T; Pretzler, G; Manahan, G G; McKenna, P; Gray, R; Wilson, R; Wiggins, S M; Welsh, G H; Beaton, A; Delinikolas, P; Jaroszynski, D A; Rosenzweig, J B; Karmakar, A; Ferlet-Cavrois, V; Costantino, A; Muschitiello, M; Daly, E


    Space radiation is a great danger to electronics and astronauts onboard space vessels. The spectral flux of space electrons, protons and ions for example in the radiation belts is inherently broadband, but this is a feature hard to mimic with conventional radiation sources. Using laser-plasma-accelerators, we reproduced relativistic, broadband radiation belt flux in the laboratory, and used this man-made space radiation to test the radiation hardness of space electronics. Such close mimicking of space radiation in the lab builds on the inherent ability of laser-plasma-accelerators to directly produce broadband Maxwellian-type particle flux, akin to conditions in space. In combination with the established sources, utilisation of the growing number of ever more potent laser-plasma-accelerator facilities worldwide as complementary space radiation sources can help alleviate the shortage of available beamtime and may allow for development of advanced test procedures, paving the way towards higher reliability of space missions.

  11. The Effects of Radiation on Imagery Sensors in Space (United States)

    Mathis, Dylan


    Recent experience using high definition video on the International Space Station reveals camera pixel degradation due to particle radiation to be a much more significant problem with high definition cameras than with standard definition video. Although it may at first appear that increased pixel density on the imager is the logical explanation for this, the ISS implementations of high definition suggest a more complex causal and mediating factor mix. The degree of damage seems to vary from one type of camera to another, and this variation prompts a reconsideration of the possible factors in pixel loss, such as imager size, number of pixels, pixel aperture ratio, imager type (CCD or CMOS), method of error correction/concealment, and the method of compression used for recording or transmission. The problem of imager pixel loss due to particle radiation is not limited to out-of-atmosphere applications. Since particle radiation increases with altitude, it is not surprising to find anecdotal evidence that video cameras subject to many hours of airline travel show an increased incidence of pixel loss. This is even evident in some standard definition video applications, and pixel loss due to particle radiation only stands to become a more salient issue considering the continued diffusion of high definition video cameras in the marketplace.

  12. Space Weather Status for Exploration Radiation Protection (United States)

    Fry, Dan J.; Lee, Kerry; Zapp, Neal; Barzilla, Janet; Dunegan, Audrey; Johnson, Steve; Stoffle, Nicholas


    Management of crew exposure to radiation is a major concern for manned spaceflight and will be even more important for the modern concept of longer-duration exploration. The inherent protection afforded to astronauts by the magnetic field of the Earth in Low Earth Orbit (LEO) makes operations on the space shuttle or space station very different from operations during an exploration mission. In order to experience significant radiation-derived Loss of Mission (LOM) or Loss of Crew (LOC) risk for LEO operations, one is almost driven to dictate extreme duration or to dictate an extreme sequence of solar activity. Outside of the geo-magnetosphere, however, this scenario changes dramatically. Exposures to the same event on the ISS and in free space, for example, may differ by orders of magnitude. This change in magnitude, coupled with the logistical constraints present in implementing any practical operational mitigation make situational awareness with regard to space weather a limiting factor for the ability to conduct exploration operations. We present a current status of developing operational concepts for manned exploration and expectations for asset viability and available predictive and characterization toolsets.

  13. Space Radar Image of Chernobyl (United States)


    This is an image of the Chernobyl nuclear power plant and its surroundings, centered at 51.17 north latitude and 30.15 west longitude. The image was acquired by the Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar aboard the space shuttle Endeavour on its 16th orbit on October 1, 1994. The area is located on the northern border of the Ukraine Republic and was produced by using the L-band (horizontally transmitted and received) polarization. The differences in the intensity are due to differences in vegetation cover, with brighter areas being indicative of more vegetation. These data were acquired as part of a collaboration between NASA and the National Space Agency of Ukraine in Remote Sensing and Earth Sciences. NASA has included several sites provided by the Ukrainian space agency as targets of opportunity during the second flight of SIR-C/X-SAR. The Ukrainian space agency also plans to conduct airborne surveys of these sites during the mission. The Chernobyl nuclear power plant is located toward the top of the image near the Pripyat River. The 12-kilometer (7.44-mile)-long cooling pond is easily distinguishable as an elongated dark shape in the center near the top of the image. The reactor complex is visible as the bright area to the extreme left of the cooling pond and the city of Chernobyl is the bright area just below the cooling pond next to the Pripyat River. The large dark area in the bottom right of the image is the Kiev Reservoir just north of Kiev. Also visible is the Dnieper River, which feeds into the Kiev Reservoir from the top of the image. The Soviet government evacuated 116,000 people within 30 kilometers (18.6 miles) of the Chernobyl reactor after the explosion and fire on April 26, 1986. Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves, allowing detailed observations at any time, regardless of weather or sunlight

  14. Ghost Imaging of Space Objects Project (United States)

    National Aeronautics and Space Administration — The NIAC research effort entitled “The Ghost Imaging of Space Objects” has been inspired by the original 1995 Ghost Imaging and Ghost Diffraction...

  15. Deformable image registration in radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Seung Jong; Kim, Si Yong [Dept. of Radiation Oncology, Virginia Commonwealth University, Richmond (United States)


    The number of imaging data sets has significantly increased during radiation treatment after introducing a diverse range of advanced techniques into the field of radiation oncology. As a consequence, there have been many studies proposing meaningful applications of imaging data set use. These applications commonly require a method to align the data sets at a reference. Deformable image registration (DIR) is a process which satisfies this requirement by locally registering image data sets into a reference image set. DIR identifies the spatial correspondence in order to minimize the differences between two or among multiple sets of images. This article describes clinical applications, validation, and algorithms of DIR techniques. Applications of DIR in radiation treatment include dose accumulation, mathematical modeling, automatic segmentation, and functional imaging. Validation methods discussed are based on anatomical landmarks, physical phantoms, digital phantoms, and per application purpose. DIR algorithms are also briefly reviewed with respect to two algorithmic components: similarity index and deformation models.

  16. Hubble Space Telescope Image of Omega Nebula (United States)


    This sturning image, taken by the newly installed Advanced Camera for Surveys (ACS) aboard the Hubble Space Telescope (HST), is an image of the center of the Omega Nebula. It is a hotbed of newly born stars wrapped in colorful blankets of glowing gas and cradled in an enormous cold, dark hydrogen cloud. The region of nebula shown in this photograph is about 3,500 times wider than our solar system. The nebula, also called M17 and the Swan Nebula, resides 5,500 light-years away in the constellation Sagittarius. The Swan Nebula is illuminated by ultraviolet radiation from young, massive stars, located just beyond the upper-right corner of the image. The powerful radiation from these stars evaporates and erodes the dense cloud of cold gas within which the stars formed. The blistered walls of the hollow cloud shine primarily in the blue, green, and red light emitted by excited atoms of hydrogen, nitrogen, oxygen, and sulfur. Particularly striking is the rose-like feature, seen to the right of center, which glows in the red light emitted by hydrogen and sulfur. As the infant stars evaporate the surrounding cloud, they expose dense pockets of gas that may contain developing stars. One isolated pocket is seen at the center of the brightest region of the nebula. Other dense pockets of gas have formed the remarkable feature jutting inward from the left edge of the image. The color image is constructed from four separate images taken in these filters: blue, near infrared, hydrogen alpha, and doubly ionized oxygen. Credit: NASA, H. Ford (JHU), G. Illingworth (USCS/LO), M. Clampin (STScI), G. Hartig (STScI), the ACS Science Team, and ESA.

  17. DNA Damage Signals and Space Radiation Risk (United States)

    Cucinotta, Francis A.


    Space radiation is comprised of high-energy and charge (HZE) nuclei and protons. The initial DNA damage from HZE nuclei is qualitatively different from X-rays or gamma rays due to the clustering of damage sites which increases their complexity. Clustering of DNA damage occurs on several scales. First there is clustering of single strand breaks (SSB), double strand breaks (DSB), and base damage within a few to several hundred base pairs (bp). A second form of damage clustering occurs on the scale of a few kbp where several DSB?s may be induced by single HZE nuclei. These forms of damage clusters do not occur at low to moderate doses of X-rays or gamma rays thus presenting new challenges to DNA repair systems. We review current knowledge of differences that occur in DNA repair pathways for different types of radiation and possible relationships to mutations, chromosomal aberrations and cancer risks.

  18. PAMELA Space Mission: The Transition Radiation Detector (United States)

    Ambriola, M.; Bellotti, R.; Cafagna, F.; Circella, M.; De Marzo, C.; Giglietto, N.; Marangelli, B.; Mirizzi, N.; Romita, M.; Spinelli, P.


    PAMELA telescope is a satellite-b orne magnetic spectrometer built to fulfill the primary scientific objectives of detecting antiparticles (antiprotons and positrons) in the cosmic rays, and to measure spectra of particles in cosmic rays. The PAMELA telescope is currently under integration and is composed of: a silicon tracker housed in a permanent magnet, a time of flight and an anticoincidence system both made of plastic scintillators, a silicon imaging calorimeter, a neutron detector and a Transition Radiation Detector (TRD). The TRD detector is composed of 9 sensitive layers of straw tubes working in proportional mode for a total of 1024 channels. Each layer is interleaved with a radiator plane made of carbon fibers. The TRD detector characteristics will be described along with its performance studied exposing the detector to particle beams of electrons, pions, muons and protons of different momenta at both CERN-PS and CERN-SPS facilities.

  19. Space storms and radiation causes and effects

    CERN Document Server

    Schrijver, Carolus J


    Heliophysics is a fast-developing scientific discipline that integrates studies of the Sun's variability, the surrounding heliosphere, and the environment and climate of planets. The Sun is a magnetically variable star and for planets with intrinsic magnetic fields, planets with atmospheres, or planets like Earth with both, there are profound consequences. This 2010 volume, the second in this series of three heliophysics texts, integrates the many aspects of space storms and the energetic radiation associated with them - from causes on the Sun to effects in planetary environments. It reviews t

  20. Radiation length imaging with high resolution telescopes


    Stolzenberg, U.; Frey, A.; Schwenker, B; Wieduwilt, P.; Marinas, C; Lütticke, F.


    The construction of low mass vertex detectors with a high level of system integration is of great interest for next generation collider experiments. Radiation length images with a sufficient spatial resolution can be used to measure and disentangle complex radiation length $X$/$X_0$ profiles and contribute to the understanding of vertex detector systems. Test beam experiments with multi GeV particle beams and high-resolution tracking telescopes provide an opportunity to obtain precise 2D imag...

  1. Nuclear Cross Sections for Space Radiation Applications (United States)

    Werneth, C. M.; Maung, K. M.; Ford, W. P.; Norbury, J. W.; Vera, M. D.


    The eikonal, partial wave (PW) Lippmann-Schwinger, and three-dimensional Lippmann-Schwinger (LS3D) methods are compared for nuclear reactions that are relevant for space radiation applications. Numerical convergence of the eikonal method is readily achieved when exact formulas of the optical potential are used for light nuclei (A = 16) and the momentum-space optical potential is used for heavier nuclei. The PW solution method is known to be numerically unstable for systems that require a large number of partial waves, and, as a result, the LS3D method is employed. The effect of relativistic kinematics is studied with the PW and LS3D methods and is compared to eikonal results. It is recommended that the LS3D method be used for high energy nucleon-nucleus reactions and nucleus-nucleus reactions at all energies because of its rapid numerical convergence and stability for both non-relativistic and relativistic kinematics.

  2. Radiation protection in medical imaging and radiation oncology

    CERN Document Server

    Stoeva, Magdalena S


    Radiation Protection in Medical Imaging and Radiation Oncology focuses on the professional, operational, and regulatory aspects of radiation protection. Advances in radiation medicine have resulted in new modalities and procedures, some of which have significant potential to cause serious harm. Examples include radiologic procedures that require very long fluoroscopy times, radiolabeled monoclonal antibodies, and intravascular brachytherapy. This book summarizes evidence supporting changes in consensus recommendations, regulations, and health physics practices associated with these recent advances in radiology, nuclear medicine, and radiation oncology. It supports intelligent and practical methods for protection of personnel, the public, and patients. The book is based on current recommendations by the International Commission on Radiological Protection and is complemented by detailed practical sections and professional discussions by the world’s leading medical and health physics professionals. It also ...

  3. Radiation biology of medical imaging

    CERN Document Server

    Kelsey, Charles A; Sandoval, Daniel J; Chambers, Gregory D; Adolphi, Natalie L; Paffett, Kimberly S


    This book provides a thorough yet concise introduction to quantitative radiobiology and radiation physics, particularly the practical and medical application. Beginning with a discussion of the basic science of radiobiology, the book explains the fast processes that initiate damage in irradiated tissue and the kinetic patterns in which such damage is expressed at the cellular level. The final section is presented in a highly practical handbook style and offers application-based discussions in radiation oncology, fractionated radiotherapy, and protracted radiation among others. The text is also supplemented by a Web site.

  4. Space Radar Image of Bahia (United States)


    This is a color composite image of southern Bahia, Brazil, centered at 15.22 degree south latitude and 39.07 degrees west longitude. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar aboard the space shuttle Endeavour on its 38th orbit of Earth on October 2, 1994. The image covers an area centered over the Una Biological Reserve, one the largest protected areas in northeastern Brazil. The 7,000-hectare reserve is administered by the Brazilian Institute for the Environment and is part of the larger Atlantic coastal forest, a narrow band of rain forest extending along the eastern coast of Brazil. The Atlantic coastal forest of southern Bahia is one of the world's most threatened and diverse ecosystems. Due to widespread settlement, only 2 to 5 percent of the original forest cover remains. Yet the region still contains an astounding variety of plants and animals, including a large number of endemic species. More than half of the region's tree species and 80 percent of its animal species are indigenous and found nowhere else on Earth. The Una Reserve is also the only federally protected habitat for the golden-headed lion tamarin, the yellow-breasted capuchin monkey and many other endangered species. In the past few years, scientists from Brazilian and international conservation organizations have coordinated efforts to study the biological diversity of this region and to develop practical and economically viable options for preserving the remaining primary forests in southern Bahia. The shuttle imaging radar is used in this study to identify various land uses and vegetation types, including remaining patches of primary forest, cabruca forest (cacao planted in the understory of the native forest), secondary forest, pasture and coastal mangrove. Standard remote-sensing technology that relies on light reflected from the forest canopy cannot accurately distinguish between cabruca and undisturbed forest. Optical remote sensing is also

  5. European activities in space radiation biology and exobiology

    Energy Technology Data Exchange (ETDEWEB)

    Horneck, G. [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Koeln (Germany)


    In view of the space station era, the European Space Agency has initiated a review and planning document for space life sciences. Radiation biology includes dosimetry of the radiation field and its modification by mass shielding, studies on the biological responses to radiation in space, on the potential impact of space flight environment on radiation effects, and assessing the radiation risks and establishing radiation protection guidelines. To reach a better understanding of the processes leading to the origin, evolution and distribution of life, exobiological activities include the exploration of the solar system, the collection and analysis of extraterrestrial samples and the utilization of space as a tool for testing the impact of space environment on organics and resistant life forms. (author)

  6. Ionizing radiation in earth's atmosphere and in space near earth. (United States)


    The Civil Aerospace Medical Institute of the FAA is charged with identifying health hazards in air travel and in : commercial human space travel. This report addresses one of these hazards ionizing radiation. : Ionizing radiation is a subatomic p...

  7. The transition radiation detector of the PAMELA space mission (United States)

    Ambriola, M.; Bellotti, R.; Cafagna, F.; Circella, M.; de Marzo, C.; Giglietto, N.; Marangelli, B.; Mirizzi, N.; Romita, M.; Spinelli, P.


    PAMELA space mission objective is to flight a satellite-borne magnetic spectrometer built to fulfill the primary scientific goals of detecting antiparticles (antiprotons and positrons) and to measure spectra of particles in cosmic rays. The PAMELA telescope is composed of: a silicon tracker housed in a permanent magnet, a time-of-flight and an anticoincidence system both made of plastic scintillators, a silicon imaging calorimeter, a neutron detector and a Transition Radiation Detector (TRD). The TRD is composed of nine sensitive layers of straw tubes working in proportional mode for a total of 1024 channels. Each layer is interleaved with a radiator plane made of carbon fibers. The TRD characteristics will be described along with its performances studied at both CERN-PS and CERN-SPS facilities, using electrons, pions, muons and protons of different momenta.

  8. Space Radiation Effect on Si Solar Cells

    Directory of Open Access Journals (Sweden)

    Jae-Jin Lee


    Full Text Available High energy charged particles are trapped by geomagnetic field in the region named Van Allen Belt. These particles can move to low altitude along magnetic field and threaten even low altitude spacecraft. Space Radiation can cause equipment failures and on occasions can even destroy operations of satellites in orbit. Sun sensors aboard Science and Technology Satellite (STSAT-1 was designed to detect sun light with silicon solar cells which performance was degraded during satellite operation. In this study, we try to identify which particle contribute to the solar cell degradation with ground based radiation facilities. We measured the short circuit current after bombarding electrons and protons on the solar cells same as STSAT-1 sun sensors. Also we estimated particle flux on the STSAT-1 orbit with analyzing NOAA POES particle data. Our result clearly shows STSAT-1 solar cell degradation was caused by energetic protons which energy is about 700 keV to 1.5 MeV. Our result can be applied to estimate solar cell conditions of other satellites.

  9. Radiation -- A Cosmic Hazard to Human Habitation in Space (United States)

    Lewis, Ruthan; Pellish, Jonathan


    Radiation exposure is one of the greatest environmental threats to the performance and success of human and robotic space missions. Radiation permeates all space and aeronautical systems, challenges optimal and reliable performance, and tests survival and survivability. We will discuss the broad scope of research, technological, and operational considerations to forecast and mitigate the effects of the radiation environment for deep space and planetary exploration.

  10. Low-Power Multi-Aspect Space Radiation Detector System (United States)

    Wrbanek, John D.; Wrbanek, Susan Y.; Fralick, Gustave; Freeman, Jon C.; Burkebile, Stephen P.


    The advanced space radiation detector development team at NASA Glenn Research Center (GRC) has the goal of developing unique, more compact radiation detectors that provide improved real-time data on space radiation. The team has performed studies of different detector designs using a variety of combinations of solid-state detectors, which allow higher sensitivity to radiation in a smaller package and operate at lower voltage than traditional detectors. Integration of all of these detector technologies will result in an improved detector system in comparison to existing state-of-the-art (SOA) instruments for the detection and monitoring of the deep space radiation field.

  11. Ghost Imaging of Space Objects Project (United States)

    National Aeronautics and Space Administration — Ghost imaging is an optical imaging technique that utilizes the correlations between optical fields in two channels. One of the channels contains the object,...

  12. Space-Ready Advanced Imaging System Project (United States)

    National Aeronautics and Space Administration — In this Phase II effort Toyon will increase the state-of-the-art for video/image systems. This will include digital image compression algorithms as well as system...

  13. Lightweight Radiator Fins for Space Nuclear Power Project (United States)

    National Aeronautics and Space Administration — This SBIR Phase 1 project shall investigate concept radiator fins that incorporate novel carbon materials for improved performance of segmented high temperature...

  14. Mid-space-independent deformable image registration. (United States)

    Aganj, Iman; Iglesias, Juan Eugenio; Reuter, Martin; Sabuncu, Mert Rory; Fischl, Bruce


    Aligning images in a mid-space is a common approach to ensuring that deformable image registration is symmetric - that it does not depend on the arbitrary ordering of the input images. The results are, however, generally dependent on the mathematical definition of the mid-space. In particular, the set of possible solutions is typically restricted by the constraints that are enforced on the transformations to prevent the mid-space from drifting too far from the native image spaces. The use of an implicit atlas has been proposed as an approach to mid-space image registration. In this work, we show that when the atlas is aligned to each image in the native image space, the data term of implicit-atlas-based deformable registration is inherently independent of the mid-space. In addition, we show that the regularization term can be reformulated independently of the mid-space as well. We derive a new symmetric cost function that only depends on the transformation morphing the images to each other, rather than to the atlas. This eliminates the need for anti-drift constraints, thereby expanding the space of allowable deformations. We provide an implementation scheme for the proposed framework, and validate it through diffeomorphic registration experiments on brain magnetic resonance images. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Titanium Loop Heat Pipes for Space Nuclear Radiators Project (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project will develop titanium Loop Heat Pipes (LHPs) that can be used in low-mass space nuclear radiators, such as...

  16. Space Qualified, Radiation Hardened, Dense Monolithic Flash Memory Project (United States)

    National Aeronautics and Space Administration — Space Micro proposes to build a radiation hardened by design (RHBD) flash memory, using a modified version of our RH-eDRAM Memory Controller to solve all the single...

  17. Space Qualified, Radiation Hardened, Dense Monolithic Flash Memory Project (United States)

    National Aeronautics and Space Administration — Radiation hardened nonvolatile memories for space is still primarily confined to EEPROM. There is high density effective or cost effective NVM solution available to...

  18. Phaseless computational imaging with a radiating metasurface

    CERN Document Server

    Fromenteze, Thomas; Boyarsky, Michael; Gollub, Jonah; Smith, David R


    Computational imaging modalities support a simplification of the active architectures required in an imaging system and these approaches have been validated across the electromagnetic spectrum. Recent implementations have utilized pseudo-orthogonal radiation patterns to illuminate an object of interest---notably, frequency-diverse metasurfaces have been exploited as fast and low-cost alternative to conventional coherent imaging systems. However, accurately measuring the complex-valued signals in the frequency domain can be burdensome, particularly for sub-centimeter wavelengths. Here, computational imaging is studied under the relaxed constraint of intensity-only measurements. A novel 3D imaging system is conceived based on 'phaseless' and compressed measurements, with benefits from recent advances in the field of phase retrieval. In this paper, the methodology associated with this novel principle is described, studied, and experimentally demonstrated in the microwave range. A comparison of the estimated imag...

  19. A space radiation transport method development (United States)

    Wilson, J. W.; Tripathi, R. K.; Qualls, G. D.; Cucinotta, F. A.; Prael, R. E.; Norbury, J. W.; Heinbockel, J. H.; Tweed, J.


    Improved spacecraft shield design requires early entry of radiation constraints into the design process to maximize performance and minimize costs. As a result, we have been investigating high-speed computational procedures to allow shield analysis from the preliminary design concepts to the final design. In particular, we will discuss the progress towards a full three-dimensional and computationally efficient deterministic code for which the current HZETRN evaluates the lowest-order asymptotic term. HZETRN is the first deterministic solution to the Boltzmann equation allowing field mapping within the International Space Station (ISS) in tens of minutes using standard finite element method (FEM) geometry common to engineering design practice enabling development of integrated multidisciplinary design optimization methods. A single ray trace in ISS FEM geometry requires 14 ms and severely limits application of Monte Carlo methods to such engineering models. A potential means of improving the Monte Carlo efficiency in coupling to spacecraft geometry is given in terms of re-configurable computing and could be utilized in the final design as verification of the deterministic method optimized design. Published by Elsevier Ltd on behalf of COSPAR.

  20. Prototype space erectable radiator system ground test article development (United States)

    Alario, Joseph P.


    A prototype heat rejecting system is being developed by NASA-JSC for possible space station applications. This modular system, the Space-Erectable Radiator System Ground Test Article (SERS-GTA) with high-capacity radiator panels, can be installed and replaced on-orbit. The design, fabrication and testing of a representative ground test article are discussed. Acceptance test data for the heat pipe radiator panel and the whiffletree clamping mechanism have been presented.

  1. Improved space bandwidth product in image upconversion

    DEFF Research Database (Denmark)

    Dam, Jeppe Seidelin; Pedersen, Christian; Tidemand-Lichtenberg, Peter


    We present a technique increasing the space bandwidth product of a nonlinear image upconversion process used for spectral imaging. The technique exploits the strong dependency of the phase-matching condition in sum frequency generation (SFG) on the angle of propagation of the interacting fields...... with respect to the optical axis. Appropriate scanning of the phase-match condition (Δk=0) while acquiring images, allow us to perform monochromatic image reconstruction with a significantly increased space bandwidth product. We derive the theory for the image reconstruction process and demonstrate acquisition...... of images with >10 fold increase in space bandwidth product, i.e. the number of pixel elements, when compared to upconversion of images using fixed phase-match conditions....

  2. Technology Developments in Radiation-Hardened Electronics for Space Environments (United States)

    Keys, Andrew S.; Howell, Joe T.


    The Radiation Hardened Electronics for Space Environments (RHESE) project consists of a series of tasks designed to develop and mature a broad spectrum of radiation hardened and low temperature electronics technologies. Three approaches are being taken to address radiation hardening: improved material hardness, design techniques to improve radiation tolerance, and software methods to improve radiation tolerance. Within these approaches various technology products are being addressed including Field Programmable Gate Arrays (FPGA), Field Programmable Analog Arrays (FPAA), MEMS, Serial Processors, Reconfigurable Processors, and Parallel Processors. In addition to radiation hardening, low temperature extremes are addressed with a focus on material and design approaches. System level applications for the RHESE technology products are discussed.

  3. Phase contrast imaging of breast tumours with synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Olivo, A. [Department of Medical Physics and Bioengineering, University College London, Malet Place, Gower Street, London WC1E 6BT (United Kingdom)], E-mail:; Rigon, L. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, Area Science Park, Padriciano 99, 34012 Trieste (Italy)], E-mail:; Vinnicombe, S.J. [Department of Radiology, St. Bartholomews Hospital, Barts and the London NHS Trust, West Smithfield, London EC1A 7BE (United Kingdom)], E-mail:; Cheung, K.C. [STFC Daresbury Laboratory, Keckwick Lane, Warrington, Cheshire WA4 4AD (United Kingdom)], E-mail:; Ibison, M. [Department of Physics, University of Liverpool, Oxford Street, Liverpool L69 7ZE (United Kingdom)], E-mail:; Speller, R.D. [Department of Medical Physics and Bioengineering, University College London, Malet Place, Gower Street, London WC1E 6BT (United Kingdom)], E-mail:


    Even though the potential of phase contrast (PC) imaging has been demonstrated in a number of biological tissue samples, the availability of free-space propagation phase contrast images of real breast tumours is still limited. The aim of this study was to obtain phase contrast images of two different pathological breast specimens containing tumours of differing morphological type at two synchrotron radiation (SR) facilities, and to assess any qualitative improvements in the evaluation and characterisation of the masses through the use of phase contrast imaging. A second aim was to assess the effects of parameters such as detector resolution, beam energy and sample-to-detector distance on image quality using the same breast specimens, as to date these effects have been modelled and discussed only for geometric phantoms. At each synchrotron radiation facility a range of images was acquired with different detectors and by varying the above parameters. Images of the same samples were also acquired with the absorption-based approach to allow a direct comparison and estimation of the advantages specifically ascribable to the PC technique.

  4. Image quality and radiation dose in cardiac imaging

    NARCIS (Netherlands)

    van Dijk, Joris David


    Coronary artery disease is a major cause of death accounting for 8% of all deaths in the Netherlands. This disease can be detected in an early stage by cardiac imaging. However, this detection comes at the price of a relatively high radiation dose which is potentially harmful for the patient.

  5. Status Report of Simulated Space Radiation Environment Facility

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Phil Hyun; Nho, Young Chang; Jeun, Joon Pyo; Choi, Jae Hak; Lim, Youn Mook; Jung, Chan Hee; Jeon, Young Kyu


    The technology for performance testing and improvement of materials which are durable at space environment is a military related technology and veiled and securely regulated in advanced countries such as US and Russia. This core technology cannot be easily transferred to other country too. Therefore, this technology is the most fundamental and necessary research area for the successful establishment of space environment system. Since the task for evaluating the effects of space materials and components by space radiation plays important role in satellite lifetime extension and running failure percentage decrease, it is necessary to establish simulated space radiation facility and systematic testing procedure. This report has dealt with the status of the technology to enable the simulation of space environment effects, including the effect of space radiation on space materials. This information such as the fundamental knowledge of space environment and research status of various countries as to the simulation of space environment effects of space materials will be useful for the research on radiation hardiness of the materials. Furthermore, it will be helpful for developer of space material on deriving a better choice of materials, reducing the design cycle time, and improving safety.

  6. Space-filling curves for image compression (United States)

    Moghaddam, Baback; Hintz, Kenneth J.; Stewart, Clayton V.


    This paper outlines the use of space-filling curves in transform image compression. Specifically, a space-filling Hilbert curve is used for mapping the two-dimensional image into a suitable one-dimensional representation. Compared to simple raster-scans, this topological mapping is spatially non-disruptive and tends to preserve local pixel correlations in the original two-dimensional image. Standard transform coefficient reduction and coding techniques can then be applied to the one-dimensional representation for the purposes of data compression. The advantages of the one-dimensional coding, in terms of computational cost and subjective image quality, are also discussed.

  7. Space Radiation Effects in Inflatable and Composite Habitat Materials (United States)

    Waller, Jess; Rojdev, Kristina


    This Year 2 project provides much needed risk reduction data to assess solar particle event (SPE) and galactic cosmic ray (GCR) space radiation damage in existing and emerging materials used in manned low-earth orbit, lunar, interplanetary, and Martian surface missions. More specifically, long duration (up to 50 years) space radiation damage is quantified for materials used in inflatable structures (1st priority), and habitable composite structures and space suits materials (2nd priority). The data collected has relevance for nonmetallic materials (polymers and composites) used in NASA missions where long duration reliability is needed in continuous or intermittent radiation fluxes.

  8. Transthoracic Cardiac Acoustic Radiation Force Impulse Imaging (United States)

    Bradway, David Pierson

    This dissertation investigates the feasibility of a real-time transthoracic Acoustic Radiation Force Impulse (ARFI) imaging system to measure myocardial function non-invasively in clinical setting. Heart failure is an important cardiovascular disease and contributes to the leading cause of death for developed countries. Patients exhibiting heart failure with a low left ventricular ejection fraction (LVEF) can often be identified by clinicians, but patients with preserved LVEF might be undetected if they do not exhibit other signs and symptoms of heart failure. These cases motivate development of transthoracic ARFI imaging to aid the early diagnosis of the structural and functional heart abnormalities leading to heart failure. M-Mode ARFI imaging utilizes ultrasonic radiation force to displace tissue several micrometers in the direction of wave propagation. Conventional ultrasound tracks the response of the tissue to the force. This measurement is repeated rapidly at a location through the cardiac cycle, measuring timing and relative changes in myocardial stiffness. ARFI imaging was previously shown capable of measuring myocardial properties and function via invasive open-chest and intracardiac approaches. The prototype imaging system described in this dissertation is capable of rapid acquisition, processing, and display of ARFI images and shear wave elasticity imaging (SWEI) movies. Also presented is a rigorous safety analysis, including finite element method (FEM) simulations of tissue heating, hydrophone intensity and mechanical index (MI) measurements, and thermocouple transducer face heating measurements. For the pulse sequences used in later animal and clinical studies, results from the safety analysis indicates that transthoracic ARFI imaging can be safely applied at rates and levels realizable on the prototype ARFI imaging system. Preliminary data are presented from in vivo trials studying changes in myocardial stiffness occurring under normal and abnormal

  9. Space Radiation and Manned Mission: Interface Between Physics and Biology (United States)

    Hei, Tom


    The natural radiation environment in space consists of a mixed field of high energy protons, heavy ions, electrons and alpha particles. Interplanetary travel to the International Space Station and any planned establishment of satellite colonies on other solar system implies radiation exposure to the crew and is a major concern to space agencies. With shielding, the radiation exposure level in manned space missions is likely to be chronic, low dose irradiation. Traditionally, our knowledge of biological effects of cosmic radiation in deep space is almost exclusively derived from ground-based accelerator experiments with heavy ions in animal or in vitro models. Radiobiological effects of low doses of ionizing radiation are subjected to modulations by various parameters including bystander effects, adaptive response, genomic instability and genetic susceptibility of the exposed individuals. Radiation dosimetry and modeling will provide conformational input in areas where data are difficult to acquire experimentally. However, modeling is only as good as the quality of input data. This lecture will discuss the interdependent nature of physics and biology in assessing the radiobiological response to space radiation.

  10. In-Space Radiator Shape Optimization using Genetic Algorithms (United States)

    Hull, Patrick V.; Kittredge, Ken; Tinker, Michael; SanSoucie, Michael


    Future space exploration missions will require the development of more advanced in-space radiators. These radiators should be highly efficient and lightweight, deployable heat rejection systems. Typical radiators for in-space heat mitigation commonly comprise a substantial portion of the total vehicle mass. A small mass savings of even 5-10% can greatly improve vehicle performance. The objective of this paper is to present the development of detailed tools for the analysis and design of in-space radiators using evolutionary computation techniques. The optimality criterion is defined as a two-dimensional radiator with a shape demonstrating the smallest mass for the greatest overall heat transfer, thus the end result is a set of highly functional radiator designs. This cross-disciplinary work combines topology optimization and thermal analysis design by means of a genetic algorithm The proposed design tool consists of the following steps; design parameterization based on the exterior boundary of the radiator, objective function definition (mass minimization and heat loss maximization), objective function evaluation via finite element analysis (thermal radiation analysis) and optimization based on evolutionary algorithms. The radiator design problem is defined as follows: the input force is a driving temperature and the output reaction is heat loss. Appropriate modeling of the space environment is added to capture its effect on the radiator. The design parameters chosen for this radiator shape optimization problem fall into two classes, variable height along the width of the radiator and a spline curve defining the -material boundary of the radiator. The implementation of multiple design parameter schemes allows the user to have more confidence in the radiator optimization tool upon demonstration of convergence between the two design parameter schemes. This tool easily allows the user to manipulate the driving temperature regions thus permitting detailed design of in-space

  11. Operator algebra in the space of images (United States)

    Celeghini, Enrico


    A consistent description of images on the disk and of their transformations is given as elements of a vector space and of an operators algebra. The vector space of images on the disk 𝔻 is the Hilbert space L 2(𝔻) that has as a basis the Zernike functions. To construct the operator algebra that transforms the images, L 2(𝔻) must be complemented and the full rigged Hilbert space RHS(𝔻) considered. Only this rigged Hilbert space allows indeed to write the operators of different cardinality we need to build the ladder operators on the Zernike functions that by inspection, belong to the representation {D}1/2+\\otimes {D}1/2+ of the algebra su(1, 1) ⊕ su(1, 1). Consequently the transformations of images are operators contained inside the universal enveloping algebra UEA[su(1, 1) ⊕ su(1, 1)]. Because of limited precision of experimental measures, physical states can be always described by vectors of the Schwartz space 𝕊(𝔻), dense in the L 2(𝔻) space where the manipulation of images is performed.

  12. Time-dependent radiation hazard estimations during space flights (United States)

    Dobynde, Mikhail; Shprits, Yuri; Drozdov, Alexander

    minimizing most harmful particle types flows. 1.Nymmik et. al., “Galactic cosmic ray flux simulation and prediction”, Adv. Space Res. 17:19-30, (1996); 2. Xu et. al., “VIP-Man: an image-based whole-body adult male model constructed from color photographs of the Visible Human Project for multi-particle Monte Carlo calculations” Health Phys. 78:476-86, (2000).

  13. Quadrilateral space syndrome: findings at MR imaging. (United States)

    Linker, C S; Helms, C A; Fritz, R C


    Shoulder pain due to compression of the axillary nerve by fibrous bands in the quadrilateral space has been termed the quadrilateral space syndrome. Selective atrophy of the teres minor muscle, which is innervated by the axillary nerve, was demonstrated at magnetic resonance imaging in three patients with clinical findings of the syndrome. This finding, in the appropriate clinical setting, is highly suggestive of the quadrilateral space syndrome, which is a potentially reversible cause of shoulder pain.

  14. Cardiovascular CT angiography in neonates and children : Image quality and potential for radiation dose reduction with iterative image reconstruction techniques

    NARCIS (Netherlands)

    Tricarico, Francesco; Hlavacek, Anthony M.; Schoepf, U. Joseph; Ebersberger, Ullrich; Nance, John W.; Vliegenthart, Rozemarijn; Cho, Young Jun; Spears, J. Reid; Secchi, Francesco; Savino, Giancarlo; Marano, Riccardo; Schoenberg, Stefan O.; Bonomo, Lorenzo; Apfaltrer, Paul

    To evaluate image quality (IQ) of low-radiation-dose paediatric cardiovascular CT angiography (CTA), comparing iterative reconstruction in image space (IRIS) and sinogram-affirmed iterative reconstruction (SAFIRE) with filtered back-projection (FBP) and estimate the potential for further dose


    Directory of Open Access Journals (Sweden)

    A. I. Altukhov


    Full Text Available The article deals with an approach to quality predicting of the space objects images, which can be used to plan optoelectronic systems of remote sensing satellites work programs. The proposed approach is based on evaluation of the optoelectronic equipment transfer properties and calculation of indexes images quality considering the influence of the orbital shooting conditions.

  16. Optical Real-Time Space Radiation Monitor Project (United States)

    National Aeronautics and Space Administration — Real-time dosimetry is needed to provide immediate feedback, so astronauts can minimize their exposure to ionizing radiation during periods of high solar activity....

  17. Radiation Hard Space Wire Gigabit Ethernet Compatible Transponder Project (United States)

    National Aeronautics and Space Administration — High-bandwidth, Radiation Hardening, low-power, low-EMI, easily reconfigurable and upgradeable transponder-based interconnects between processor nodes, subsystems,...

  18. The Space Radiation: Nature, Biological Effects and Shielding (United States)

    Muradian, Kh.

    The latest findings in origin, biological effects and shielding of the space ionizing radiation (SIR) are reviewed. It is stressed that after the impending implementation of artificial gravity, SIR could become the most serious concern for deep space travelers. SIR is more effective in induction of the genome- and cell-associated damages, compared with the conventional radioactive sources. The shielding of SIR is augmented due to the secondary spallation δ-radiation and possible cooperation with weightlessness and other negative impacts of a space flight. The panspermia concept postulating the existence of living organisms, e.g. bacterial spores, in space and their natural interplanetary transportation is discussed.

  19. ASTRO-1 Space Telescope for Hubble-class Space Imaging (United States)

    Morse, Jon A.


    The 1.8-meter ASTRO-1 space telescope is designed to provide UV-visible imaging and spectroscopy that will be lost when the Hubble Space Telescope is finally decommissioned, probably early next decade. This privately funded facility will impact a broad range of astronomical research topics, from exoplanets to cosmology. We describe the proposed facility and our plans to involve the amateur astronomy community in the observatory planning and on-orbit observing program.

  20. Brijuni Conference (10th), Imaging in Space and Time. Held in Brijuni, Croatia on 28 August-1 September 2006

    National Research Council Canada - National Science Library

    Bosanac, Slobodan D


    .... The conference included: A) Acquiring and analyzing data from space. Much of information on distant objects in space is obtained from images in various frequency domains of electromagnetic radiation...

  1. Research-grade CMOS image sensors for demanding space applications (United States)

    Saint-Pé, Olivier; Tulet, Michel; Davancens, Robert; Larnaudie, Franck; Magnan, Pierre; Corbière, Franck; Martin-Gonthier, Philippe; Belliot, Pierre


    Imaging detectors are key elements for optical instruments and sensors on board space missions dedicated to Earth observation (high resolution imaging, atmosphere spectroscopy...), Solar System exploration (micro cameras, guidance for autonomous vehicle...) and Universe observation (space telescope focal planes, guiding sensors...). This market has been dominated by CCD technology for long. Since the mid- 90s, CMOS Image Sensors (CIS) have been competing with CCDs for more and more consumer domains (webcams, cell phones, digital cameras...). Featuring significant advantages over CCD sensors for space applications (lower power consumption, smaller system size, better radiations behaviour...), CMOS technology is also expanding in this field, justifying specific R&D and development programs funded by national and European space agencies (mainly CNES, DGA, and ESA). All along the 90s and thanks to their increasingly improving performances, CIS have started to be successfully used for more and more demanding applications, from vision and control functions requiring low-level performances to guidance applications requiring medium-level performances. Recent technology improvements have made possible the manufacturing of research-grade CIS that are able to compete with CCDs in the high-performances arena. After an introduction outlining the growing interest of optical instruments designers for CMOS image sensors, this talk will present the existing and foreseen ways to reach high-level electro-optics performances for CIS. The developments of CIS prototypes built using an imaging CMOS process and of devices based on improved designs will be presented.

  2. Acceptability of risk from radiation: Application to human space flight

    Energy Technology Data Exchange (ETDEWEB)



    This one of NASA`s sponsored activities of the NCRP. In 1983, NASA asked NCRP to examine radiation risks in space and to make recommendations about career radiation limits for astronauts (with cancer considered as the principal risk). In conjunction with that effort, NCRP was asked to convene this symposium; objective is to examine the technical, strategic, and philosophical issues pertaining to acceptable risk and radiation in space. Nine papers are included together with panel discussions and a summary. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  3. IC space radiation effects experimental simulation and estimation methods

    CERN Document Server

    Chumakov, A I; Telets, V A; Gerasimov, V F; Yanenko, A V; Sogoyan, A V


    Laboratory test simulation methods are developed for IC response prediction to space radiation. The minimum set of radiation simulators is proposed to investigate IC failures and upsets under space radiation. The accelerated test technique of MOS ICs degradation estimation are developed for low intensity irradiation taking into account temperature variations as well as latent degradation effects. Two-parameter cross section functions are adapted to describe the ion- and proton-induced single event upsets. Non-focused laser irradiation is found to be applicable for single event latchup threshold estimation.

  4. Late Immunobiological Effects of Space Radiation (United States)


    higher than those of non-irradiated control subjects (Sado, et al, 1978). Alternatively , radiation-induced genetic defects might result in inhibition of...mulatta. Folia Primat 12:313 (1970). 3. Eterman, K. P. and T. E. W. Feltkamp. Antibodies to gluten and reticulin in gastrointestinal diseases. Clin Exp

  5. Combined injury syndrome in space-related radiation environments (United States)

    Dons, R. F.; Fohlmeister, U.

    The risk of combined injury (CI) to space travelers is a function of exposure to anomalously large surges of a broad spectrum of particulate and photon radiations, conventional trauma (T), and effects of weightlessness including decreased intravascular fluid volume, and myocardial deconditioning. CI may occur even at relatively low doses of radiation which can synergistically enhance morbidity and mortality from T. Without effective countermeasures, prolonged residence in space is expected to predispose most individuals to bone fractures as a result of calcium loss in the microgravity environment. Immune dysfunction may occur from residence in space independent of radiation exposure. Thus, wound healing would be compromised if infection were to occur. Survival of the space traveler with CI would be significantly compromised if there were delays in wound closure or in the application of simple supportive medical or surgical therapies. Particulate radiation has the potential for causing greater gastrointestinal injury than photon radiation, but bone healing should not be compromised at the expected doses of either type of radiation in space.

  6. The radiation protection problems of high altitude and space flight

    Energy Technology Data Exchange (ETDEWEB)

    Fry, R.J.M.


    This paper considers the radiation environment in aircraft at high altitudes and spacecraft in low earth orbit and in deep space and the factors that influence the dose equivalents. Altitude, latitude and solar cycle are the major influences for flights below the radiation belts. In deep space, solar cycle and the occurrence of solar particle events are the factors of influence. The major radiation effects of concern are cancer and infertility in males. In high altitude aircraft the radiation consists mainly of protons and neutrons, with neutrons contributing about half the equivalent dose. The average dose rate at altitudes of transcontinental flights that approach the polar regions are greater by a factor of about 2.5 than on routes at low latitudes. Current estimates of does to air crews suggest they are well within the ICRP (1990) recommended dose limits for radiation workers.

  7. The radiation protection problems of high altitude and space flight

    Energy Technology Data Exchange (ETDEWEB)

    Fry, R.J.M.


    This paper considers the radiation environment in aircraft at high altitudes and spacecraft in low earth orbit and in deep space and the factors that influence the dose equivalents. Altitude, latitude and solar cycle are the major influences for flights below the radiation belts. In deep space, solar cycle and the occurrence of solar particle events are the factors of influence. The major radiation effects of concern are cancer and infertility in males. In high altitude aircraft the radiation consists mainly of protons and neutrons, with neutrons contributing about half the equivalent dose. The average dose rate at altitudes of transcontinental flights that approach the polar regions are greater by a factor of about 2.5 than on routes at low latitudes. Current estimates of does to air crews suggest they are well within the ICRP (1990) recommended dose limits for radiation workers.

  8. Device and Method of Scintillating Quantum Dots for Radiation Imaging (United States)

    Burke, Eric R. (Inventor); DeHaven, Stanton L. (Inventor); Williams, Phillip A. (Inventor)


    A radiation imaging device includes a radiation source and a micro structured detector comprising a material defining a surface that faces the radiation source. The material includes a plurality of discreet cavities having openings in the surface. The detector also includes a plurality of quantum dots disclosed in the cavities. The quantum dots are configured to interact with radiation from the radiation source, and to emit visible photons that indicate the presence of radiation. A digital camera and optics may be used to capture images formed by the detector in response to exposure to radiation.

  9. Space radiation risks to the central nervous system (United States)

    Cucinotta, Francis A.; Alp, Murat; Sulzman, Frank M.; Wang, Minli


    Central nervous system (CNS) risks which include during space missions and lifetime risks due to space radiation exposure are of concern for long-term exploration missions to Mars or other destinations. Possible CNS risks during a mission are altered cognitive function, including detriments in short-term memory, reduced motor function, and behavioral changes, which may affect performance and human health. The late CNS risks are possible neurological disorders such as premature aging, and Alzheimer's disease (AD) or other dementia. Radiation safety requirements are intended to prevent all clinically significant acute risks. However the definition of clinically significant CNS risks and their dependences on dose, dose-rate and radiation quality is poorly understood at this time. For late CNS effects such as increased risk of AD, the occurrence of the disease is fatal with mean time from diagnosis of early stage AD to death about 8 years. Therefore if AD risk or other late CNS risks from space radiation occur at mission relevant doses, they would naturally be included in the overall acceptable risk of exposure induced death (REID) probability for space missions. Important progress has been made in understanding CNS risks due to space radiation exposure, however in general the doses used in experimental studies have been much higher than the annual galactic cosmic ray (GCR) dose (∼0.1 Gy/y at solar maximum and ∼0.2 Gy/y at solar minimum with less than 50% from HZE particles). In this report we summarize recent space radiobiology studies of CNS effects from particle accelerators simulating space radiation using experimental models, and make a critical assessment of their relevance relative to doses and dose-rates to be incurred on a Mars mission. Prospects for understanding dose, dose-rate and radiation quality dependencies of CNS effects and extrapolation to human risk assessments are described.

  10. Recent measurements for hadrontherapy and space radiation: nuclear physics (United States)

    Miller, J.


    The particles and energies commonly used for hadron therapy overlap the low end of the charge and energy range of greatest interest for space radiation applications, Z=1-26 and approximately 100-1000 MeV/nucleon. It has been known for some time that the nuclear interactions of the incident ions must be taken into account both in treatment planning and in understanding and addressing the effects of galactic cosmic ray ions on humans in space. Until relatively recently, most of the studies of nuclear fragmentation and transport in matter were driven by the interests of the nuclear physics and later, the hadron therapy communities. However, the experimental and theoretical methods and the accelerator facilities developed for use in heavy ion nuclear physics are directly applicable to radiotherapy and space radiation studies. I will briefly review relevant data taken recently at various accelerators, and discuss the implications of the measurements for radiotherapy, radiobiology and space radiation research.

  11. Non Radiation Hardened Microprocessors in Spaced Based Remote Sensing Systems (United States)

    Decoursey, Robert J.; Estes, Robert F.; Melton, Ryan


    The CALIPSO (Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations) mission is a comprehensive suite of active and passive sensors including a 20Hz 230mj Nd:YAG lidar, a visible wavelength Earth-looking camera and an imaging infrared radiometer. CALIPSO flies in formation with the Earth Observing System Post-Meridian (EOS PM) train, provides continuous, near-simultaneous measurements and is a planned 3 year mission. CALIPSO was launched into a 98 degree sun synchronous Earth orbit in April of 2006 to study clouds and aerosols and acquires over 5 gigabytes of data every 24 hours. The ground track of one CALIPSO orbit as well as high and low intensity South Atlantic Anomaly outlines is shown. CALIPSO passes through the SAA several times each day. Spaced based remote sensing systems that include multiple instruments and/or instruments such as lidar generate large volumes of data and require robust real-time hardware and software mechanisms and high throughput processors. Due to onboard storage restrictions and telemetry downlink limitations these systems must pre-process and reduce the data before sending it to the ground. This onboard processing and realtime requirement load may mean that newer more powerful processors are needed even though acceptable radiation-hardened versions have not yet been released. CALIPSO's single board computer payload controller processor is actually a set of four (4) voting non-radiation hardened COTS Power PC 603r's built on a single width VME card by General Dynamics Advanced Information Systems (GDAIS). Significant radiation concerns for CALIPSO and other Low Earth Orbit (LEO) satellites include the South Atlantic Anomaly (SAA), the north and south poles and strong solar events. Over much of South America and extending into the South Atlantic Ocean the Van Allen radiation belts dip to just 200-800km and spacecraft entering this area are subjected to high energy protons and experience higher than normal Single Event Upset

  12. Probabilistic Assessment of Radiation Risk for Astronauts in Space Missions (United States)

    Kim, Myung-Hee; DeAngelis, Giovanni; Cucinotta, Francis A.


    Accurate predictions of the health risks to astronauts from space radiation exposure are necessary for enabling future lunar and Mars missions. Space radiation consists of solar particle events (SPEs), comprised largely of medium energy protons, (less than 100 MeV); and galactic cosmic rays (GCR), which include protons and heavy ions of higher energies. While the expected frequency of SPEs is strongly influenced by the solar activity cycle, SPE occurrences themselves are random in nature. A solar modulation model has been developed for the temporal characterization of the GCR environment, which is represented by the deceleration potential, phi. The risk of radiation exposure from SPEs during extra-vehicular activities (EVAs) or in lightly shielded vehicles is a major concern for radiation protection, including determining the shielding and operational requirements for astronauts and hardware. To support the probabilistic risk assessment for EVAs, which would be up to 15% of crew time on lunar missions, we estimated the probability of SPE occurrence as a function of time within a solar cycle using a nonhomogeneous Poisson model to fit the historical database of measurements of protons with energy > 30 MeV, (phi)30. The resultant organ doses and dose equivalents, as well as effective whole body doses for acute and cancer risk estimations are analyzed for a conceptual habitat module and a lunar rover during defined space mission periods. This probabilistic approach to radiation risk assessment from SPE and GCR is in support of mission design and operational planning to manage radiation risks for space exploration.

  13. Radiation events in astronomical CCD images

    Energy Technology Data Exchange (ETDEWEB)

    Smith, A.R.; McDonald, R.J.; Hurley, D.L.; Holland, S.E.; Groom, D.E.; Brown, W.E.; Gilmore, D.K.; Stover, R.J.; Wei, M.


    The remarkable sensitivity of depleted silicon to ionizing radiation is a nuisance to astronomers. ''Cosmic rays'' degrade images because of struck pixels, leading to modified observing strategies and the development of algorithms to remove the unwanted artifacts. In the new-generation CCD's with thick sensitive regions, cosmic-ray muons make recognizable straight tracks and there is enhanced sensitivity to ambient gamma radiation via Compton-scattered electrons (''worms''). Beta emitters inside the dewar, for example high-potassium glasses such as BK7, also produce worm-like tracks. The cosmic-ray muon rate is irreducible and increases with altitude. The gamma rays are mostly by-products of the U and Th decay chains; these elements always appear as traces in concrete and other materials. The Compton recoil event rate can be reduced significantly by the choice of materials in the environment and dewar and by careful shielding. Telescope domes appear to be significantly cleaner than basement laboratories and Coude spectrograph rooms. Radiation sources inside the dewar can be eliminated by judicious choice of materials. Cosmogenic activation during high-altitude flights does not appear to be a problem. Our conclusions are supported by tests at the Lawrence Berkeley National Laboratory low-level counting facilities in Berkeley and at Oroville, California (180 m underground).

  14. Space Images for NASA JPL Android Version (United States)

    Nelson, Jon D.; Gutheinz, Sandy C.; Strom, Joshua R.; Arca, Jeremy M.; Perez, Martin; Boggs, Karen; Stanboli, Alice


    This software addresses the demand for easily accessible NASA JPL images and videos by providing a user friendly and simple graphical user interface that can be run via the Android platform from any location where Internet connection is available. This app is complementary to the iPhone version of the application. A backend infrastructure stores, tracks, and retrieves space images from the JPL Photojournal and Institutional Communications Web server, and catalogs the information into a streamlined rating infrastructure. This system consists of four distinguishing components: image repository, database, server-side logic, and Android mobile application. The image repository contains images from various JPL flight projects. The database stores the image information as well as the user rating. The server-side logic retrieves the image information from the database and categorizes each image for display. The Android mobile application is an interfacing delivery system that retrieves the image information from the server for each Android mobile device user. Also created is a reporting and tracking system for charting and monitoring usage. Unlike other Android mobile image applications, this system uses the latest emerging technologies to produce image listings based directly on user input. This allows for countless combinations of images returned. The backend infrastructure uses industry-standard coding and database methods, enabling future software improvement and technology updates. The flexibility of the system design framework permits multiple levels of display possibilities and provides integration capabilities. Unique features of the software include image/video retrieval from a selected set of categories, image Web links that can be shared among e-mail users, sharing to Facebook/Twitter, marking as user's favorites, and image metadata searchable for instant results.

  15. Projection x-space magnetic particle imaging. (United States)

    Goodwill, Patrick W; Konkle, Justin J; Zheng, Bo; Saritas, Emine U; Conolly, Steven M


    Projection magnetic particle imaging (MPI) can improve imaging speed by over 100-fold over traditional 3-D MPI. In this work, we derive the 2-D x-space signal equation, 2-D image equation, and introduce the concept of signal fading and resolution loss for a projection MPI imager. We then describe the design and construction of an x-space projection MPI scanner with a field gradient of 2.35 T/m across a 10 cm magnet free bore. The system has an expected resolution of 3.5 × 8.0 mm using Resovist tracer, and an experimental resolution of 3.8 × 8.4 mm resolution. The system images 2.5 cm × 5.0 cm partial field-of views (FOVs) at 10 frames/s, and acquires a full field-of-view of 10 cm × 5.0 cm in 4 s. We conclude by imaging a resolution phantom, a complex "Cal" phantom, mice injected with Resovist tracer, and experimentally confirm the theoretically predicted x-space spatial resolution.

  16. Development of space foods using radiation technology

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ju-Woon; Byun, Myung-Woo; Kim, Jae-Hun; Song, Beom-Suk; Choi, Jong-IL; Park, Jin-Kyu; Park, Jae-Nam; Han, In-Jun


    Four Korean food items (Kimchi, ready-to-eat fermented vegetable; Ramen, ready-to-cook noodles; Nutrition bar, ready-to-eat raw grain bar; Sujeonggwa, cinnamon beverage) have been developed as space foods by the application of high-dose gamma irradiation. All Korean space foods were certificated for use in space flight conditions during 30 days by the Russian Institute of Biomedical Problems. Establishment of research protocols on muscle atrophy mechanism using two-dimensional electrophoresis and various blotting analyses are conducted. And two bio-active molecules that potentially play an preventive role of muscle atrophy are uncovered. Integrative protocols linking between the effect of bio-active molecules and treadmill exercise for muscle atrophy inhibition are established. Reduction in body temperature and heartbeat rate were monitored after HIT injection to mice was conducted. Development of Korean astronaut preferred flavoring for space food was conducted to reduced atherogenic index (AI) than butter fat. The spread added honey and pineapple essence was preferred spreadability and overall flavor by sensory evaluation. Flavor was affected by irradiation source ({gamma}-ray or electron beam) or irradiation dosage (10, 20, 30, 40 and 50 kGy) using electronic nose system an space foods using gamma irradiation pH of porridge was mostly stable and pH increased. Most of TBARS value was generally low, and there wasn't any significant difference. Consistency, viscosity, and firmness was higher in round rice porridge and half rice porridge than in rice powder porridge, and increase in added water amount led to decrease of all textural properties.

  17. Simulating Space Radiation-Induced Breast Tumor Incidence Using Automata. (United States)

    Heuskin, A C; Osseiran, A I; Tang, J; Costes, S V


    Estimating cancer risk from space radiation has been an ongoing challenge for decades primarily because most of the reported epidemiological data on radiation-induced risks are derived from studies of atomic bomb survivors who were exposed to an acute dose of gamma rays instead of chronic high-LET cosmic radiation. In this study, we introduce a formalism using cellular automata to model the long-term effects of ionizing radiation in human breast for different radiation qualities. We first validated and tuned parameters for an automata-based two-stage clonal expansion model simulating the age dependence of spontaneous breast cancer incidence in an unexposed U.S. We then tested the impact of radiation perturbation in the model by modifying parameters to reflect both targeted and nontargeted radiation effects. Targeted effects (TE) reflect the immediate impact of radiation on a cell's DNA with classic end points being gene mutations and cell death. They are well known and are directly derived from experimental data. In contrast, nontargeted effects (NTE) are persistent and affect both damaged and undamaged cells, are nonlinear with dose and are not well characterized in the literature. In this study, we introduced TE in our model and compared predictions against epidemiologic data of the atomic bomb survivor cohort. TE alone are not sufficient for inducing enough cancer. NTE independent of dose and lasting ∼100 days postirradiation need to be added to accurately predict dose dependence of breast cancer induced by gamma rays. Finally, by integrating experimental relative biological effectiveness (RBE) for TE and keeping NTE (i.e., radiation-induced genomic instability) constant with dose and LET, the model predicts that RBE for breast cancer induced by cosmic radiation would be maximum at 220 keV/μm. This approach lays the groundwork for further investigation into the impact of chronic low-dose exposure, inter-individual variation and more complex space radiation

  18. Radiation Belt Environment Model: Application to Space Weather and Beyond (United States)

    Fok, Mei-Ching H.


    Understanding the dynamics and variability of the radiation belts are of great scientific and space weather significance. A physics-based Radiation Belt Environment (RBE) model has been developed to simulate and predict the radiation particle intensities. The RBE model considers the influences from the solar wind, ring current and plasmasphere. It takes into account the particle drift in realistic, time-varying magnetic and electric field, and includes diffusive effects of wave-particle interactions with various wave modes in the magnetosphere. The RBE model has been used to perform event studies and real-time prediction of energetic electron fluxes. In this talk, we will describe the RBE model equation, inputs and capabilities. Recent advancement in space weather application and artificial radiation belt study will be discussed as well.

  19. Detection of DNA damage by space radiation in human fibroblasts flown on the International Space Station (United States)

    Lu, Tao; Zhang, Ye; Wong, Michael; Feiveson, Alan; Gaza, Ramona; Stoffle, Nicholas; Wang, Huichen; Wilson, Bobby; Rohde, Larry; Stodieck, Louis; Karouia, Fathi; Wu, Honglu


    Although charged particles in space have been detected with radiation detectors on board spacecraft since the discovery of the Van Allen Belts, reports on the effects of direct exposure to space radiation in biological systems have been limited. Measurement of biological effects of space radiation is challenging due to the low dose and low dose rate nature of the radiation environment, and due to the difficulty in distinguishing the radiation effects from microgravity and other space environmental factors. In astronauts, only a few changes, such as increased chromosome aberrations in their lymphocytes and early onset of cataracts, are attributed primarily to their exposure to space radiation. In this study, cultured human fibroblasts were flown on the International Space Station (ISS). Cells were kept at 37 °C in space for 14 days before being fixed for analysis of DNA damage with the γ-H2AX assay. The 3-dimensional γ-H2AX foci were captured with a laser confocal microscope. Quantitative analysis revealed several foci that were larger and displayed a track pattern only in the Day 14 flight samples. To confirm that the foci data from the flight study was actually induced from space radiation exposure, cultured human fibroblasts were exposed to low dose rate γ rays at 37 °C. Cells exposed to chronic γ rays showed similar foci size distribution in comparison to the non-exposed controls. The cells were also exposed to low- and high-LET protons, and high-LET Fe ions on the ground. Our results suggest that in G1 human fibroblasts under the normal culture condition, only a small fraction of large size foci can be attributed to high-LET radiation in space.

  20. Detection of DNA Damage by Space Radiation in Human Fibroblasts Flown on the International Space Station (United States)

    Lu, Tao; Zhang, Ye; Wong, Michael; Feiveson, Alan; Gaza, Ramona; Stoffle, Nicholas; Wang, Huichen; Wilson, Bobby; Rohde, Larry; Stodieck, Louis; hide


    Although charged particles in space have been detected with radiation detectors on board spacecraft since the discovery of the Van Allen Belts, reports on the effects of direct exposure to space radiation in biological systems have been limited. Measurement of biological effects of space radiation is challenging due to the low dose and low dose rate nature of the radiation environment, and due to the difficulty in distinguishing the radiation effects from microgravity and other space environmental factors. In astronauts, only a few changes, such as increased chromosome aberrations in their lymphocytes and early onset of cataracts, are attributed primarily to their exposure to space radiation. In this study, cultured human fibroblasts were flown on the International Space Station (ISS). Cells were kept at 37 degrees Centigrade in space for 14 days before being fixed for analysis of DNA damages with the gamma-H2AX assay. The 3-dimensional gamma-H2AX foci were captured with a laser confocal microscope. Quantitative analysis revealed several foci that were larger and displayed a track pattern only in the Day 14 flight samples. To confirm that the foci data from the flight study was actually induced from space radiation exposure, cultured human fibroblasts were exposed to low dose rate gamma rays at 37 degrees Centigrade. Cells exposed to chronic gamma rays showed similar foci size distribution in comparison to the non-exposed controls. The cells were also exposed to low- and high-LET (Linear Energy Transfer) protons, and high-LET Fe ions on the ground. Our results suggest that in G1 human fibroblasts under the normal culture condition, only a small fraction of large size foci can be attributed to high-LET radiation in space.

  1. Review of Nuclear Physics Experiments for Space Radiation (United States)

    Norbury, John W.; Miller, Jack; Adamczyk, Anne M.; Heilbronn, Lawrence H.; Townsend, Lawrence W.; Blattnig, Steve R.; Norman, Ryan B.; Guetersloh, Stephen B.; Zeitlin, Cary J.


    Human space flight requires protecting astronauts from the harmful effects of space radiation. The availability of measured nuclear cross section data needed for these studies is reviewed in the present paper. The energy range of interest for radiation protection is approximately 100 MeV/n to 10 GeV/n. The majority of data are for projectile fragmentation partial and total cross sections, including both charge changing and isotopic cross sections. The cross section data are organized into categories which include charge changing, elemental, isotopic for total, single and double differential with respect to momentum, energy and angle. Gaps in the data relevant to space radiation protection are discussed and recommendations for future experiments are made.

  2. Commercial Regional Space/Airborne Imaging (United States)


    1-4 1 Landsat 5 Space Imaging Multispectral Multispectral Optical 30 80 185 185 16 16 LandSat 7 US. Government Panchromatic...upgrade except by replacement. However small satelites (they are designed to have 5-year design life and can be upgraded before re- lauch) and UAVs

  3. Development of a compact radiation monitor for space application


    Stein, Timo Alexander


    In this work a compact radiation monitor prototype has been developed. The present device and its technology will directly contribute towards the CPT-SCOPE project, a Norwegian-German student project developing a radiation monitor for space application. The present design utilises an application specific integrated circuit (ASIC) which provides a low-power and small-form factor solution. Such system is required for small satellites and CubeSats. The development of the device has been car...

  4. Space Weather Effects in the Earth's Radiation Belts (United States)

    Baker, D. N.; Erickson, P. J.; Fennell, J. F.; Foster, J. C.; Jaynes, A. N.; Verronen, P. T.


    The first major scientific discovery of the Space Age was that the Earth is enshrouded in toroids, or belts, of very high-energy magnetically trapped charged particles. Early observations of the radiation environment clearly indicated that the Van Allen belts could be delineated into an inner zone dominated by high-energy protons and an outer zone dominated by high-energy electrons. The energy distribution, spatial extent and particle species makeup of the Van Allen belts has been subsequently explored by several space missions. Recent observations by the NASA dual-spacecraft Van Allen Probes mission have revealed many novel properties of the radiation belts, especially for electrons at highly relativistic and ultra-relativistic kinetic energies. In this review we summarize the space weather impacts of the radiation belts. We demonstrate that many remarkable features of energetic particle changes are driven by strong solar and solar wind forcings. Recent comprehensive data show broadly and in many ways how high energy particles are accelerated, transported, and lost in the magnetosphere due to interplanetary shock wave interactions, coronal mass ejection impacts, and high-speed solar wind streams. We also discuss how radiation belt particles are intimately tied to other parts of the geospace system through atmosphere, ionosphere, and plasmasphere coupling. The new data have in many ways rewritten the textbooks about the radiation belts as a key space weather threat to human technological systems.

  5. Electromagnetic radiation in a semi-compact space (United States)

    Iso, Satoshi; Kitazawa, Noriaki; Yokoo, Sumito


    In this note, we investigate the electromagnetic radiation emitted from a revolving point charge in a compact space. If the point charge is circulating with an angular frequency ω0 on the (x , y)-plane at z = 0 with boundary conditions, x ∼ x + 2 πR and y ∼ y + 2 πR, it emits radiation into the z-direction of z ∈ [ - ∞ , + ∞ ]. We find that the radiation shows discontinuities as a function of ω0 R at which a new propagating mode with a different Fourier component appears. For a small radius limit ω0 R ≪ 1, all the Fourier modes except the zero mode on (x , y)-plane are killed, but an effect of squeezing the electric field totally enhances the radiation. In the large volume limit ω0 R → ∞, the energy flux of the radiation reduces to the expected Larmor formula.

  6. Gamma radiation in ceramic capacitors: a study for space missions (United States)

    dos Santos Ferreira, Eduardo; Sarango Souza, Juliana


    We studied the real time effects of the gamma radiation in ceramic capacitors, in order to evaluate the effects of cosmic radiation on these devices. Space missions have electronic circuits with various types of devices, many studies have been done on semiconductor devices exposed to gamma radiation, but almost no studies for passive components, in particular ceramic capacitors. Commercially sold ceramic capacitors were exposed to gamma radiation, and the capacitance was measured before and after exposure. The results clearly show that the capacitance decreases with exposure to gamma radiation. We confirmed this observation in a real time capacitance measurement, obtained using a data logging system developed by us using the open source Arduino platform.

  7. Lightweight space radiator with leakage control by internal electrostatic fields (United States)

    Kim, Hyo; Bankoff, S. G.; Miksis, Michael J.


    An electrostatic liquid film space radiator is proposed. This will employ an internal electrostatic field to prevent leakage of the liquid-metal coolant out of a puncture. This overcomes the major disadvantage of membrane radiators, which is their vulnerability to micrometeorite impacts. Calculations show that leaks of liquid lithium at 700° K can easily be stopped from punctures which are several mm in diameter, with very large safety factors. The basic idea lends itself to a variety of radiator concepts, both rotating and non-rotating. Some typical film thickness and pressure calculations in the presence of an electric field are shown.

  8. High-Performance, Radiation-Hardened Electronics for Space Environments (United States)

    Keys, Andrew S.; Watson, Michael D.; Frazier, Donald O.; Adams, James H.; Johnson, Michael A.; Kolawa, Elizabeth A.


    The Radiation Hardened Electronics for Space Environments (RHESE) project endeavors to advance the current state-of-the-art in high-performance, radiation-hardened electronics and processors, ensuring successful performance of space systems required to operate within extreme radiation and temperature environments. Because RHESE is a project within the Exploration Technology Development Program (ETDP), RHESE's primary customers will be the human and robotic missions being developed by NASA's Exploration Systems Mission Directorate (ESMD) in partial fulfillment of the Vision for Space Exploration. Benefits are also anticipated for NASA's science missions to planetary and deep-space destinations. As a technology development effort, RHESE provides a broad-scoped, full spectrum of approaches to environmentally harden space electronics, including new materials, advanced design processes, reconfigurable hardware techniques, and software modeling of the radiation environment. The RHESE sub-project tasks are: SelfReconfigurable Electronics for Extreme Environments, Radiation Effects Predictive Modeling, Radiation Hardened Memory, Single Event Effects (SEE) Immune Reconfigurable Field Programmable Gate Array (FPGA) (SIRF), Radiation Hardening by Software, Radiation Hardened High Performance Processors (HPP), Reconfigurable Computing, Low Temperature Tolerant MEMS by Design, and Silicon-Germanium (SiGe) Integrated Electronics for Extreme Environments. These nine sub-project tasks are managed by technical leads as located across five different NASA field centers, including Ames Research Center, Goddard Space Flight Center, the Jet Propulsion Laboratory, Langley Research Center, and Marshall Space Flight Center. The overall RHESE integrated project management responsibility resides with NASA's Marshall Space Flight Center (MSFC). Initial technology development emphasis within RHESE focuses on the hardening of Field Programmable Gate Arrays (FPGA)s and Field Programmable Analog

  9. Some comments on space flight and radiation limits

    Energy Technology Data Exchange (ETDEWEB)

    Thornton, W.E.


    Setting limits on human exposure to space-related radiation involves two very different processes - the appropriate hard science, and certain emotional aspects and expectations of the groups involved. These groups include the general public and their elected politicians, the astronauts and flight crews, and NASA managers, each group with different expectations and concerns. Public and political views of human space flight and human radiation exposures are often poorly informed and are often based on emotional reactions to current events which may be distorted by {open_quotes}experts{close_quotes} and the media. Career astronauts` and cosmonauts` views are much more realistic about the risks involved and there is a willingness on their part to accept increased necessary risks. However, there is a concern on their part about career-threatening dose limits, the potential for overexposures, and the health effects from all sources of radiation. There is special concern over radiation from medical studies. This last concern continues to raise the question of {open_quotes}voluntary{close_quotes} participation in studies involving radiation exposure. There is greatly diversity in spaceflight crews and their expectations; and {open_quotes}official{close_quotes} Astronaut Office positions will reflect strong management direction. NASA management has its own priorities and concerns and this fact will be reflected in their crucial influence on radiation limits. NASA, and especially spaceflight crews, might be best served by exposure limits which address all sources of spaceflight radiation and all potential effects from such exposure.

  10. ISS and Space Shuttle Radiation Measurements at Solar Minimum (United States)

    Gaza, Ramona; Welton, Andrew; Dunegan, Audrey; Lee, Kerry


    A summary of 2008-2011 ISS and Space Shuttle radiation dosimetry results for inside vehicle radiation monitoring in low-Earth orbit will be presented. Results include new data from ISS Expedition 22-25/20A radiation area monitors (RAM) and Shuttle Missions STS127-STS133 passive radiation dosimeters (PRD). ISS 20A radiation measurement locations included three Node 2 crew quarters locations at NOD2S5_CQ, NOD2P5_CQ and CQ-3 (Deck), as well as ESA Columbus, and JAXA Kibo locations. ISS 20A and STS127-STS133 missions were flown at 51.6 inclination with an altitude range of 330-350 km. The passive radiation results will be presented in terms of measured daily dose obtained using luminescence detectors (i.e., Al2O3:C, LiF:Mg,Ti and CaF2:Tm). In addition, preliminary results from the DOSIS 2 Project, in collaboration with the German Space Agency (DLR) will be presented. SRAG s participation to the DOSIS 2 exposure on ISS (11/16/2009-05/26/2010) involved passive radiation measurements at 10 different shielding locations inside the ESA Columbus Module.

  11. Space Radar Image of Central Sumatra, Indonesia (United States)


    This is a radar image of the central part of the island of Sumatra in Indonesia that shows how the tropical rainforest typical of this country is being impacted by human activity. Native forest appears in green in this image, while prominent pink areas represent places where the native forest has been cleared. The large rectangular areas have been cleared for palm oil plantations. The bright pink zones are areas that have been cleared since 1989, while the dark pink zones are areas that were cleared before 1989. These radar data were processed as part of an effort to assist oil and gas companies working in the area to assess the environmental impact of both their drilling operations and the activities of the local population. Radar images are useful in these areas because heavy cloud cover and the persistent smoke and haze associated with deforestation have prevented usable visible-light imagery from being acquired since 1989. The dark shapes in the upper right (northeast) corner of the image are a chain of lakes in flat coastal marshes. This image was acquired in October 1994 by the Spaceborne Imaging Radar C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) onboard the space shuttle Endeavour. Environmental changes can be easily documented by comparing this image with visible-light data that were acquired in previous years by the Landsat satellite. The image is centered at 0.9 degrees north latitude and 101.3 degrees east longitude. The area shown is 50 kilometers by 100 kilometers (31 miles by 62 miles). The colors in the image are assigned to different frequencies and polarizations of the radar as follows: red is L-band horizontally transmitted, horizontally received; green is L-band horizontally transmitted, vertically received; blue is L-band vertically transmitted, vertically received. SIR-C/X-SAR, a joint mission of the German, Italian and United States space agencies, is part of NASA's Mission to Planet Earth program.

  12. Study on biological response to space radiation and its countermeasure

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jong Il; Lee, Ju Woon; Kim, Dong Ho; Kim, Jae Hun; Song, Beom Suk; Kim, Jae Kyung; Park, Jong Heum; Kim, Jin Kyu [KAERI, Daejeon (Korea, Republic of)


    The purpose is to develop the core technologies for the advanced life supporting system based on radiation technology by 2015 and to be a member of G7 in the space technology research field. And it is the final aim that contribution for establishment of the self-supporting technology and national strength by 2020. To simulate the space environment of microgravity and expose to space radiation, denervation model was established in Gamma Phytotron. The changes in microflora population in animal model was shown. The effect of simulated microgravity and long-term exposure to irradiation was investigated. In the experiment of MARS 500, crews for expedition to Mars had been served by Korean space foods (Bulgogi, Bibimbap, Seaweed soup, Mulberry beverage, Kimchi, Sujeonggwa) for 120 days, then their immunity will be examined and compared with it on the ground.

  13. The Polarized Radiation Imaging and Spectroscopy Mission

    CERN Document Server

    André, Philippe; Banday, Anthony; Barbosa, Domingos; Barreiro, Belen; Bartlett, James; Bartolo, Nicola; Battistelli, Elia; Battye, Richard; Bendo, George; Benoȋt, Alain; Bernard, Jean-Philippe; Bersanelli, Marco; Béthermin, Matthieu; Bielewicz, Pawel; Bonaldi, Anna; Bouchet, François; Boulanger, François; Brand, Jan; Bucher, Martin; Burigana, Carlo; Cai, Zhen-Yi; Camus, Philippe; Casas, Francisco; Casasola, Viviana; Castex, Guillaume; Challinor, Anthony; Chluba, Jens; Chon, Gayoung; Colafrancesco, Sergio; Comis, Barbara; Cuttaia, Francesco; D'Alessandro, Giuseppe; Da Silva, Antonio; Davis, Richard; de Avillez, Miguel; de Bernardis, Paolo; de Petris, Marco; de Rosa, Adriano; de Zotti, Gianfranco; Delabrouille, Jacques; Désert, François-Xavier; Dickinson, Clive; Diego, Jose Maria; Dunkley, Joanna; Enßlin, Torsten; Errard, Josquin; Falgarone, Edith; Ferreira, Pedro; Ferrière, Katia; Finelli, Fabio; Fletcher, Andrew; Fosalba, Pablo; Fuller, Gary; Galli, Silvia; Ganga, Ken; García-Bellido, Juan; Ghribi, Adnan; Giard, Martin; Giraud-Héraud, Yannick; Gonzalez-Nuevo, Joaquin; Grainge, Keith; Gruppuso, Alessandro; Hall, Alex; Hamilton, Jean-Christophe; Haverkorn, Marijke; Hernandez-Monteagudo, Carlos; Herranz, Diego; Jackson, Mark; Jaffe, Andrew; Khatri, Rishi; Kunz, Martin; Lamagna, Luca; Lattanzi, Massimiliano; Leahy, Paddy; Lesgourgues, Julien; Liguori, Michele; Liuzzo, Elisabetta; Lopez-Caniego, Marcos; Macias-Perez, Juan; Maffei, Bruno; Maino, Davide; Mangilli, Anna; Martinez-Gonzalez, Enrique; Martins, Carlos J.A.P.; Masi, Silvia; Massardi, Marcella; Matarrese, Sabino; Melchiorri, Alessandro; Melin, Jean-Baptiste; Mennella, Aniello; Mignano, Arturo; Miville-Deschênes, Marc-Antoine; Monfardini, Alessandro; Murphy, Anthony; Naselsky, Pavel; Nati, Federico; Natoli, Paolo; Negrello, Mattia; Noviello, Fabio; O'Sullivan, Créidhe; Paci, Francesco; Pagano, Luca; Paladino, Rosita; Palanque-Delabrouille, Nathalie; Paoletti, Daniela; Peiris, Hiranya; Perrotta, Francesca; Piacentini, Francesco; Piat, Michel; Piccirillo, Lucio; Pisano, Giampaolo; Polenta, Gianluca; Pollo, Agnieszka; Ponthieu, Nicolas; Remazeilles, Mathieu; Ricciardi, Sara; Roman, Matthieu; Rosset, Cyrille; Rubino-Martin, Jose-Alberto; Salatino, Maria; Schillaci, Alessandro; Shellard, Paul; Silk, Joseph; Starobinsky, Alexei; Stompor, Radek; Sunyaev, Rashid; Tartari, Andrea; Terenzi, Luca; Toffolatti, Luigi; Tomasi, Maurizio; Trappe, Neil; Tristram, Matthieu; Trombetti, Tiziana; Tucci, Marco; Van de Weijgaert, Rien; Van Tent, Bartjan; Verde, Licia; Vielva, Patricio; Wandelt, Ben; Watson, Robert; Withington, Stafford; Cabrera, Nicolas


    PRISM (Polarized Radiation Imaging and Spectroscopy Mission) was proposed to ESA in May 2013 as a large-class mission for investigating within the framework of the ESA Cosmic Vision program a set of important scientific questions that require high resolution, high sensitivity, full-sky observations of the sky emission at wavelengths ranging from millimeter-wave to the far-infrared. PRISM's main objective is to explore the distant universe, probing cosmic history from very early times until now as well as the structures, distribution of matter, and velocity flows throughout our Hubble volume. PRISM will survey the full sky in a large number of frequency bands in both intensity and polarization and will measure the absolute spectrum of sky emission more than three orders of magnitude better than COBE FIRAS. The aim of this Extended White Paper is to provide a more detailed overview of the highlights of the new science that will be made possible by PRISM

  14. Interactive Image Recognition of Space Target Objects (United States)

    Zeng, Xianheng; Sun, Hanxu


    An interactive image pre-processing algorithm is proposed to solve the problem that the target object is not accurate and the calculation is time consuming when the space robot is in orbit. Firstly, the Grabcut algorithm is improved to identify the space object. The Gaussian filtering, edge detection, morphological processing and other methods are combined with Grabcut algorithm. Then the Hough transform algorithm is improved, and the straight line with similar slope is fitted, and the intersection of the straight line is obtained, which is the key point of the object to describe the spatial coordinates of the object. Through the experimental verification, the method proposed in this paper can meet the task of identifying the object of the space object, which can improve the accuracy and recognition speed of the object recognition and reduce the time taken to identify the space object.

  15. Detection of DNA Damage by Space Radiation in Human Fibroblasts Flown on the International Space Station (United States)

    Lu, Tao; Zhang, Ye; Wong, Michael; Feiveson, Alan; Gaza, Ramona; Stoffle, Nicholas; Wang, Huichen; Wilson, Bobby; Rohde, Larry; Stodieck, Louis; hide


    Space radiation consists of energetic charged particles of varying charges and energies. Exposure of astronauts to space radiation on future long duration missions to Mars, or missions back to the Moon, is expected to result in deleterious consequences such as cancer and comprised central nervous system (CNS) functions. Space radiation can also cause mutation in microorganisms, and potentially influence the evolution of life in space. Measurement of the space radiation environment has been conducted since the very beginning of the space program. Compared to the quantification of the space radiation environment using physical detectors, reports on the direct measurement of biological consequences of space radiation exposure have been limited, due primarily to the low dose and low dose rate nature of the environment. Most of the biological assays fail to detect the radiation effects at acute doses that are lower than 5 centiSieverts. In a recent study, we flew cultured confluent human fibroblasts in mostly G1 phase of the cell cycle to the International Space Station (ISS). The cells were fixed in space after arriving on the ISS for 3 and 14 days, respectively. The fixed cells were later returned to the ground and subsequently stained with the gamma-H2AX (Histone family, member X) antibody that are commonly used as a marker for DNA damage, particularly DNA double strand breaks, induced by both low-and high-linear energy transfer radiation. In our present study, the gamma-H2AX (Histone family, member X) foci were captured with a laser confocal microscope. To confirm that some large track-like foci were from space radiation exposure, we also exposed, on the ground, the same type of cells to both low-and high-linear energy transfer protons, and high-linear energy transfer Fe ions. In addition, we exposed the cells to low dose rate gamma rays, in order to rule out the possibility that the large track-like foci can be induced by chronic low-linear energy transfer

  16. Space Radar Image of Mineral Resources, China (United States)


    This spaceborne radar image of a mineral-rich region in southern China is being used by geologists to identify potential new areas for mineral exploration. The area shown is the vicinity of the city of Zhao Qing, the light blue area along the banks of the River Xi Jiang in the lower left. This is in the southern Chinese province of Guangdong, about 75 kilometers (46 miles) west of Guangzhou (Canton). The largest gold mine in southern China is located in the far upper left of the image along a brightly reflective mountain ridge. Using the radar image as a guide, geologists are tracing the extension of the ridge structure to the east (right) to identify possible mining areas. Radar imaging is especially useful for this purpose because of its sensitivity to subtle topographic structure, even in areas such as these, which have a dense vegetation cover. The Xi Jiang area is one of the most productive mining regions in China, with deposits of tungsten, lead, zinc and gold. The image was acquired by the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) onboard the space shuttleEndeavour on April 17, 1994. The image is centered at 37.2 degreesnorth latitude and 112.5 degrees east longitude. North is toward the upper right. The image shows an area 60 kilometers by 38 kilometers (37.2 miles by 23.6 miles) The colors are assigned to different frequencies and polarizations of the radar as follows: red is L-band, horizontally transmitted, horizontally received; green is L-band, horizontally transmitted, vertically received; blue is C-band, horizontally transmitted, vertically received. SIR-C/X-SAR, a joint mission of the German, Italian and United States space agencies, is part of NASA's Mission to Planet Earthprogram.

  17. Comparative assessment of three image reconstruction techniques for image quality and radiation dose in patients undergoing abdominopelvic multidetector CT examinations (United States)

    Desai, G S; Thabet, A; Elias, A Y A; Sahani, D V


    Objective To compare image quality and radiation dose of abdominal CT examinations reconstructed with three image reconstruction techniques. Methods In this Institutional Review Board-approved study, contrast-enhanced (CE) abdominopelvic CT scans from 23 patients were reconstructed using filtered back projection (FBP), adaptive statistical iterative reconstruction (ASiR) and iterative reconstruction in image space (IRIS) and were reviewed by two blinded readers. Subjective (acceptability, sharpness, noise and artefacts) and objective (noise) measures of image quality were recorded for each image data set. Radiation doses in CT dose index (CTDI) dose–length product were also calculated for each examination type and compared. Imaging parameters were compared using the Wilcoxon signed rank test and a paired t-test. Results All 69 CECT examinations were of diagnostic quality and similar for overall acceptability (mean grade for ASiR, 3.9±0.3; p=0.2 for Readers 1 and 2; IRIS, 3.9±0.4, p=0.2; FBP, 3.8±0.9). Objective noise was considerably lower with both iterative techniques (pASiR and IRIS). Recorded mean radiation dose, i.e. CTDIvol, was 24% and 10% less with ASiR (11.4±3.4 mGy; preconstructed with ASiR and IRIS provide diagnostic images with reduced image noise and 10–24% lower radiation dose than FBP. Advances in knowledge CT images reconstructed with FBP are frequently noisy on lowering the radiation dose. Newer iterative reconstruction techniques have different approaches to produce images with less noise; ASiR and IRIS provide diagnostic abdominal CT images with reduced image noise and radiation dose compared with FBP. This has been documented in this study. PMID:23255538

  18. Smoke, Clouds and Radiation Brazil NASA ER-2 Moderate Resolution Imaging Spectrometer (MODIS) Airborne Simulator (MAS) Data (United States)

    National Aeronautics and Space Administration — SCARB_ER2_MAS data are Smoke, Clouds and Radiation Brazil (SCARB) NASA ER2 Moderate Resolution Imaging Spectrometer (MODIS) Airborne Simulator (MAS)...

  19. Space Radar Image of Star City, Russia (United States)


    This radar image shows the Star City cosmonaut training center, east of Moscow, Russia. Four American astronauts are training here for future long-duration flights aboard the Russian Mir space station. These joint flights are giving NASA and the Russian Space Agency experience necessary for the construction of the international Alpha space station, beginning in late 1997. This image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR), on its 62nd orbit on October 3, 1994. This Star City image is centered at 55.55 degrees north latitude and 38.0 degrees east longitude. The area shown is approximately 32 kilometers by 49 kilometers (20 miles by 30 miles). North is to the top in this image. The radar illumination is from the top of the image. The image was produced using three channels of SIR-C radar data: red indicates L-band (23 cm wavelength, horizontally transmitted and received); green indicates L-band (horizontally transmitted and vertically received); blue indicates C-band (6 cm wavelength, horizontally transmitted and vertically received). In general, dark pink areas are agricultural; pink and light blue areas are urban communities; black areas represent lakes and rivers; dark blue areas are cleared forest; and light green areas are forested. The prominent black runways just right of center are Shchelkovo Airfield, about 4 km long. The textured pale blue-green area east and southeast of Shchelkovo Airfield is forest. Just east of the runways is a thin railroad line running southeast; the Star City compound lies just east of the small bend in the rail line. Star City contains the living quarters and training facilities for Russian cosmonauts and their families. Moscow's inner loop road is visible at the lower left edge of the image. The Kremlin is just off the left edge, on the banks of the meandering Moskva River. The Klyazma River snakes to the southeast from the reservoir in the upper left (shown in bright red

  20. NASA Space Radiation Risk Project: Overview and Recent Results (United States)

    Blattnig, Steve R.; Chappell, Lori J.; George, Kerry A.; Hada, Megumi; Hu, Shaowen; Kidane, Yared H.; Kim, Myung-Hee Y.; Kovyrshina, Tatiana; Norman, Ryan B.; Nounu, Hatem N.; hide


    The NASA Space Radiation Risk project is responsible for integrating new experimental and computational results into models to predict risk of cancer and acute radiation syndrome (ARS) for use in mission planning and systems design, as well as current space operations. The project has several parallel efforts focused on proving NASA's radiation risk projection capability in both the near and long term. This presentation will give an overview, with select results from these efforts including the following topics: verification, validation, and streamlining the transition of models to use in decision making; relative biological effectiveness and dose rate effect estimation using a combination of stochastic track structure simulations, DNA damage model calculations and experimental data; ARS model improvements; pathway analysis from gene expression data sets; solar particle event probabilistic exposure calculation including correlated uncertainties for use in design optimization.

  1. The lens, cataracts and space-related radiations (United States)

    Worgul, B.

    Of considerable moment in the annals of space-related radiation studies is the recent report of radiogenic cataracts among the astronauts (Cucinotta et al., 2002. Rad. Res. 156: 460). Although generally unexpected, the finding was fully predicted by a number of experimental studies on high LET radiation cataractogenesis. Historically, the lens and its primary pathology, cataract, have played important roles in the elucidation of the nuances of the biological response to ioniz ing radiation. So too their study has contributed greatly to an appreciation of the cell and tissue effects of exposure to high - LET radiation . Findings from cataract studies have validated, at the level of complex tissue expression, evidence for extremely large RBEs at low doses and the inverse dose-rate effect observed in other systems. The extensive experiment al studies on radiation cataractogenesis in rodents presaged and predicted the recent report of radiogenic cataracts in the astronaut corps. It is therefore important to revisit and re-evaluate the existing experimental data on lens damage following high-LET radiation exposure. Also given the circumstances, the tissue without question deserves continued investigative exploitation and scrutiny. In addition greater attention should be paid to the potential the lens as a surrogate for tissues less amenable to non - invasive longitudinal examination. Currently the lens and cataract studies are again providing insights into fundamental biological processes while at the same time establishing additional bases for medical follow-up. Among the highly relevant studies are our recent findings which support the concept of a genetic predisposition to radiation sensitivity. Individuals with elevated radiation sensitivity may not be appropriate choices for manned forays into space. Also of particular concern is the potentially complicating influence of the bystander effect/adaptive response for determining risk of developing cataracts from space

  2. Radiation exposure from diagnostic imaging among patients with gastrointestinal disorders.

    LENUS (Irish Health Repository)

    Desmond, Alan N


    There are concerns about levels of radiation exposure among patients who undergo diagnostic imaging for inflammatory bowel disease (IBD), compared with other gastrointestinal (GI) disorders. We quantified imaging studies and estimated the cumulative effective dose (CED) of radiation received by patients with organic and functional GI disorders. We also identified factors and diagnoses associated with high CEDs.

  3. Space Radar Image of Manaus, Brazil (United States)


    These two images were created using data from the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR). On the left is a false-color image of Manaus, Brazil acquired April 12, 1994, onboard space shuttle Endeavour. In the center of this image is the Solimoes River just west of Manaus before it combines with the Rio Negro to form the Amazon River. The scene is around 8 by 8 kilometers (5 by 5 miles) with north toward the top. The radar image was produced in L-band where red areas correspond to high backscatter at HH polarization, while green areas exhibit high backscatter at HV polarization. Blue areas show low backscatter at VV polarization. The image on the right is a classification map showing the extent of flooding beneath the forest canopy. The classification map was developed by SIR-C/X-SAR science team members at the University of California,Santa Barbara. The map uses the L-HH, L-HV, and L-VV images to classify the radar image into six categories: Red flooded forest Green unflooded tropical rain forest Blue open water, Amazon river Yellow unflooded fields, some floating grasses Gray flooded shrubs Black floating and flooded grasses Data like these help scientists evaluate flood damage on a global scale. Floods are highly episodic and much of the area inundated is often tree-covered. Spaceborne Imaging Radar-C and X-Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground studies, will give scientists clearer insights into those environmental changes which are caused by nature and those

  4. Space Radar Image of Vesuvius, Italy (United States)


    Mt. Vesuvius, one of the best known volcanoes in the world primarily for the eruption that buried the Roman city of Pompeii, is shown in the center of this radar image. The central cone of Vesuvius is the dark purple feature in the center of the volcano. This cone is surrounded on the northern and eastern sides by the old crater rim, called Mt. Somma. Recent lava flows are the pale yellow areas on the southern and western sides of the cone. Vesuvius is part of a large volcanic zone which includes the Phalagrean Fields, the cluster of craters seen along the left side of the image. The Bay of Naples, on the left side of the image, is separated from the Gulf of Salerno, in the lower left, by the Sorrento Peninsula. Dense urban settlement can be seen around the volcano. The city of Naples is above and to the left of Vesuvius; the seaport of the city can be seen in the top of the bay. Pompeii is located just below the volcano on this image. The rapid eruption in 79 A.D. buried the victims and buildings of Pompeii under several meters of debris and killed more than 2,000 people. Due to the violent eruptive style and proximity to populated areas, Vesuvius has been named by the international scientific community as one of fifteen Decade Volcanoes which are being intensively studied during the 1990s. The image is centered at 40.83 degrees North latitude, 14.53 degrees East longitude. It shows an area 100 kilometers by 55 kilometers (62 miles by 34 miles.) This image was acquired on April 15, 1994 by the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the Space Shuttle Endeavour. SIR-C/X-SAR, a joint mission of the German, Italian and the United States space agencies, is part of NASA's Mission to Planet Earth.

  5. Inheritance of induction radiation sensitivity of space flight environments and γ-radiation on rice (United States)

    Xu, J.; Wang, J.; Wei, L.; Li, Z.; Sun, Y.

    There are many factors affecting living things during space flight, such as microgravity, cosmic radiation, etc. A large number of plant mutants have been obtained after space flight on satellite in China in the last decade and some commercial crop varieties were released. However, little consideration has so far been given to the genetic mechanisms underlying sensitivity of plant seeds to space flight environments. To reveal the genetic mechanisms associated with induction radiation sensitivity (IRS), a set of 226 recombination inbred lines (RILs) derived from Lemont (japonica)/ Teqing (indica) F13, were analyzed using 164 well-distributed DNA markers and assayed for the traits related to IRS including rate of survival seedling (RSS), seedling height (SH), seed setting rate (SSR) and total physiological damage (TPD) in replicated trials after space flight on Chinese Shenzhou IV Spacecraft andγ -radiation treatment (35000 rad) on the ground in 2002. Seedling growth of Lemont was accelerated after space flight with the SH of 116.2% of ground control while growth suppression was happened for Teqing with the SH of 85.7% of ground control. γ -radiation treatment resulted in significant decrease in all tested traits for the two parents, indicating space flight and γ -radiation treatment had different biological effects on the two parents. Significant differences were detected among the RILs for their responses to space flight environments and γ -radiation, reflected as the difference in the four tested traits. Space flight resulted in stimulation on growth for 57.1% lines whileγ -radiation had suppression on growth for most lines. Seventeen putative main-effect QTLs was identified for the four traits related to IRS under space flight and γ -radiation, which totally explained significant portions of the total trait variation (4.4% for RSS, 27.2% for SH, 4% for SSR and 15.8% for TPD for space flight; 10.4% for RSS, 15.1% for SH, 8.2% for SSR and 6.1% for TPD for

  6. Space debris detection in optical image sequences. (United States)

    Xi, Jiangbo; Wen, Desheng; Ersoy, Okan K; Yi, Hongwei; Yao, Dalei; Song, Zongxi; Xi, Shaobo


    We present a high-accuracy, low false-alarm rate, and low computational-cost methodology for removing stars and noise and detecting space debris with low signal-to-noise ratio (SNR) in optical image sequences. First, time-index filtering and bright star intensity enhancement are implemented to remove stars and noise effectively. Then, a multistage quasi-hypothesis-testing method is proposed to detect the pieces of space debris with continuous and discontinuous trajectories. For this purpose, a time-index image is defined and generated. Experimental results show that the proposed method can detect space debris effectively without any false alarms. When the SNR is higher than or equal to 1.5, the detection probability can reach 100%, and when the SNR is as low as 1.3, 1.2, and 1, it can still achieve 99%, 97%, and 85% detection probabilities, respectively. Additionally, two large sets of image sequences are tested to show that the proposed method performs stably and effectively.

  7. Semiclassical TEM image formation in phase space. (United States)

    Lubk, Axel; Röder, Falk


    Current developments in TEM such as high-resolution imaging at low acceleration voltages and large fields of view, the ever larger capabilities of hardware aberration correction and the systematic shaping of electron beams require accurate descriptions of TEM imaging in terms of wave optics. Since full quantum mechanic solutions have not yet been established for, e.g., the theory of aberrations, we are exploring semiclassical image formation in the TEM from the perspective of quantum mechanical phase space, here. Firstly, we use two well-known semiclassical approximations, Miller's semiclassical algebra and the frozen Gaussian method, for describing the wave optical generalization of arbitrary geometric aberrations, including nonisoplanatic and slope aberrations. Secondly, we demonstrate that the Wigner function representation of phase space is well suited to also describe incoherent aberrations as well as the ramifications of partial coherence due to the emission process at the electron source. We identify a close relationship between classical phase space and Wigner function distortions due to aberrations as well as classical brightness and quantum mechanical purity. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. A perceptual space of local image statistics. (United States)

    Victor, Jonathan D; Thengone, Daniel J; Rizvi, Syed M; Conte, Mary M


    Local image statistics are important for visual analysis of textures, surfaces, and form. There are many kinds of local statistics, including those that capture luminance distributions, spatial contrast, oriented segments, and corners. While sensitivity to each of these kinds of statistics have been well-studied, much less is known about visual processing when multiple kinds of statistics are relevant, in large part because the dimensionality of the problem is high and different kinds of statistics interact. To approach this problem, we focused on binary images on a square lattice - a reduced set of stimuli which nevertheless taps many kinds of local statistics. In this 10-parameter space, we determined psychophysical thresholds to each kind of statistic (16 observers) and all of their pairwise combinations (4 observers). Sensitivities and isodiscrimination contours were consistent across observers. Isodiscrimination contours were elliptical, implying a quadratic interaction rule, which in turn determined ellipsoidal isodiscrimination surfaces in the full 10-dimensional space, and made predictions for sensitivities to complex combinations of statistics. These predictions, including the prediction of a combination of statistics that was metameric to random, were verified experimentally. Finally, check size had only a mild effect on sensitivities over the range from 2.8 to 14min, but sensitivities to second- and higher-order statistics was substantially lower at 1.4min. In sum, local image statistics form a perceptual space that is highly stereotyped across observers, in which different kinds of statistics interact according to simple rules. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Design and performance oof space station photovoltaic radiators (United States)

    White, K. Alan; Fleming, Mike L.; Lee, Avis Y.


    The design and performance of the Space Station Freedom Photovoltaic (PV) Power Module Thermal Control System radiators is presented. The PV Radiator is of a single phase pumped loop design using liquid ammonia as the coolant. Key design features are described, including the base structure, deployment mechanism, radiator panels, and two independent coolant loops. The basis for a specific mass of 7.8 kg/sqm is discussed, and methods of lowering this number for future systems are briefly described. Key performance paramters are also addressed. A summary of test results and analysis is presented to illustrate the survivability of the radiator in the micrometeoroid and orbital debris environment. A design criterion of 95% probability of no penetration of both fluid loops over a 10 year period is shown to be met. Methods of increasing the radiator survivability even further are presented. Thermal performance is also discussed, including a comparison of modeling predictions with existing test results. Degradation in thermal performance due to exposure to atomic oxygen and ultraviolet radiation in the low Earth orbit environment is presented. The structural criteria to which the radiator is designed are also briefly addressed. Finally, potential design improvements are discussed.

  10. Towards Space Exploration of Moon, Mars Neos: Radiation Biological Basis (United States)

    Hellweg, Christine; Baumstark-Khan, Christa; Berger, Thomas; Reitz, Guenther


    Radiation has emerged as the most critical issue to be resolved for long-term missions both orbital and interplanetary. Astronauts are constantly exposed to galactic cosmic radiation (GCR) of various energies with a low dose rate. Primarily late tissue sequels like genetic alterations, cancer and non-cancer effects, i.e. cataracts and degenerative diseases of e.g. the central nervous system or the cardiovascular system, are the potential risks. Cataracts were observed to occur earlier and more often in astronauts exposed to higher proportions of galactic ions (Cucinotta et al., 2001). Predictions of cancer risk and acceptable radiation exposure in space are subject to many uncertainties including the relative biological effectiveness (RBE) of space radiation especially heavy ions, dose-rate effects and possible interaction with microgravity and other spaceflight environmental factors. The initial cellular response to radiation exposure paves the way to late sequelae and starts with damage to the DNA which complexity depends on the linear energy transfer (LET) of the radiation. Repair of such complex DNA damage is more challenging and requires more time than the repair of simple DNA double strand breaks (DSB) which can be visualized by immunofluorescence staining of the phosphorylated histone 2AX (γH2AX) and might explain the observed prolonged cell cycle arrests induced by high-LET in comparison to low-LET irradiation. Unrepaired or mis-repaired DNA DSB are proposed to be responsible for cell death, mutations, chromosomal aberrations and oncogenic cell transformation. Cell killing and mutation induction are most efficient in an LET range of 90-200 keV/µm. Also the activation of transcription factors such as Nuclear Factor κB (NF-κB) and gene expression shaping the cellular radiation response depend on the LET with a peak RBE between 90 and 300 keV/µm. Such LET-RBE relationships were observed for cataract and cancer induction by heavy ions in laboratory animals

  11. Space Radar Image of Sydney, Australia (United States)


    This spaceborne radar image is dominated by the metropolitan area of Australia's largest city, Sydney. Sydney Harbour, with numerous coves and inlets, is seen in the upper center of the image, and the roughly circular Botany Bay is shown in the lower right. The downtown business district of Sydney appears as a bright white area just above the center of the image. The Sydney Harbour Bridge is a white line adjacent to the downtown district. The well-known Sydney Opera House is the small, white dot to the right of the bridge. Urban areas appear yellow, blue and brown. The purple areas are undeveloped areas and park lands. Manly, the famous surfing beach, is shown in yellow at the top center of the image. Runways from the Sydney Airport are the dark features that extend into Botany Bay in the lower right. Botany Bay is the site where Captain James Cook first landed his ship, Endeavour, in 1770. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) on April 20, 1994, onboard the space shuttle Endeavour. The area shown is 33 kilometers by 38kilometers (20 miles by 23 miles) and is centered at 33.9 degrees south latitude, 151.2 degrees east longitude. North is toward the upper left. The colors are assigned to different radar frequenciesand polarizations as follows: red is L-band, vertically transmittedand horizontally received; green is C-band, vertically transmitted and horizontally received; and blue is C-band, vertically transmittedand received. SIR-C/X-SAR, a joint mission of the German, Italianand United States space agencies, is part of NASA's Mission to Planet Earth. #####

  12. Space radar image of New Orleans, Louisiana (United States)


    This image of the area surrounding the city of New Orleans, Louisiana in the southeastern United States demonstrates the ability of multi-frequency imaging radar to distinguish different types of land cover. The dark area in the center is Lake Pontchartrain. The thin line running across the lake is a causeway connecting New Orleans to the city of Mandeville. Lake Borgne is the dark area in the lower right of the image. The Mississippi River appears as a dark, wavy line in the lower left. The white dots on the Mississippi are ships. The French Quarter is the brownish square near the left center of the image. Lakefront Airport, a field used mostly for general aviation, is the bright spot near the center, jutting out into Lake Pontchartrain. The image was acquired by the Spaceborne Imaging Radar C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) during orbit 39 of space shuttle Endeavour on October 2, 1994. The area is located at 30.10 degrees north latitude and 89.1 degrees west longitude. The area shown is approximately 100 kilometers (60 miles) by 50 kilometers (30 miles). The colors in this image were obtained using the following radar channels: red represents the L-band (horizontally transmitted and received); green represents the C-band (horizontally transmitted and received); blue represents the L-band (vertically transmitted and received). The green areas are primarily vegetation consisting of swamp land and swamp forest (bayou) growing on sandy soil, while the pink areas are associated with reflections from buildings in urban and suburban areas. Different tones and colors in the vegetation areas will be studied by scientists to see how effective imaging radar data is in discriminating between different types of wetlands. Accurate maps of coastal wetland areas are important to ecologists studying wild fowl and the coastal environment.

  13. Space Radar Image of Kiluchevskoi, Volcano, Russia (United States)


    This is an image of the area of Kliuchevskoi volcano, Kamchatka, Russia, which began to erupt on September 30, 1994. Kliuchevskoi is the blue triangular peak in the center of the image, towards the left edge of the bright red area that delineates bare snow cover. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on its 88th orbit on October 5, 1994. The image shows an area approximately 75 kilometers by 100 kilometers (46 miles by 62 miles) that is centered at 56.07 degrees north latitude and 160.84 degrees east longitude. North is toward the bottom of the image. The radar illumination is from the top of the image. The Kamchatka volcanoes are among the most active volcanoes in the world. The volcanic zone sits above a tectonic plate boundary, where the Pacific plate is sinking beneath the northeast edge of the Eurasian plate. The Endeavour crew obtained dramatic video and photographic images of this region during the eruption, which will assist scientists in analyzing the dynamics of the recent activity. The colors in this image were obtained using the following radar channels: red represents the L-band (horizontally transmitted and received); green represents the L-band (horizontally transmitted and vertically received); blue represents the C-band (horizontally transmitted and vertically received). In addition to Kliuchevskoi, two other active volcanoes are visible in the image. Bezymianny, the circular crater above and to the right of Kliuchevskoi, contains a slowly growing lava dome. Tolbachik is the large volcano with a dark summit crater near the upper right edge of the red snow covered area. The Kamchatka River runs from right to left across the bottom of the image. The current eruption of Kliuchevskoi included massive ejections of gas, vapor and ash, which reached altitudes of 15,000 meters (50,000 feet). Melting snow mixed with volcanic ash triggered mud flows on the

  14. A Freezable Heat Exchanger for Space Suit Radiator Systems (United States)

    Nabity, James A.; Mason, Georgia R.; Copeland, Robert J.; Trevino, Luis a.


    During an ExtraVehicular Activity (EVA), both the heat generated by the astronaut s metabolism and that produced by the Portable Life Support System (PLSS) must be rejected to space. The heat sources include the heat of adsorption of metabolic CO2, the heat of condensation of water, the heat removed from the body by the liquid cooling garment and the load from the electrical components. Although the sublimator hardware to reject this load weighs only 1.58 kg (3.48 lbm), an additional 3.6 kg (8 lbm) of water are loaded into the unit, most of which is sublimated and lost to space, thus becoming the single largest expendable during an eight-hour EVA. Using a radiator to reject heat from the astronaut during an EVA can reduce the amount of expendable water consumed in the sublimator. Radiators have no moving parts and are thus highly reliable. Past freezable radiators have been too heavy, but the weight can be greatly reduced by placing a small and freeze tolerant heat exchanger between the astronaut and radiator, instead of making the very large radiator freeze tolerant. Therefore, the key technological innovation to improve space suit radiator performance was the development of a lightweight and freezable heat exchanger that accommodates the variable heat load generated by the astronaut. Herein, we present the heat transfer performance of a newly designed heat exchanger that endured several freeze / thaw cycles without any apparent damage. The heat exchanger was also able to continuously turn down or turn up the heat rejection to follow the variable load.

  15. Countermeasures for Space Radiation Induced Malignancies and Acute Biological Effects (United States)

    Kennedy, Ann

    The hypothesis being evaluated in this research program is that control of radiation induced oxidative stress will reduce the risk of radiation induced adverse biological effects occurring as a result of exposure to the types of radiation encountered during space travel. As part of this grant work, we have evaluated the protective effects of several antioxidants and dietary supplements and observed that a mixture of antioxidants (AOX), containing L-selenomethionine, N-acetyl cysteine (NAC), ascorbic acid, vitamin E succinate, and alpha-lipoic acid, is highly effective at reducing space radiation induced oxidative stress in both in vivo and in vitro systems, space radiation induced cytotoxicity and malignant transformation in vitro [1-7]. In studies designed to determine whether the AOX formulation could affect radiation induced mortality [8], it was observed that the AOX dietary supplement increased the 30-day survival of ICR male mice following exposure to a potentially lethal dose (8 Gy) of X-rays when given prior to or after animal irradiation. Pretreatment of animals with antioxidants resulted in significantly higher total white blood cell and neutrophil counts in peripheral blood at 4 and 24 hours following exposure to doses of 1 Gy and 8 Gy. Antioxidant treatment also resulted in increased bone marrow cell counts following irradiation, and prevented peripheral lymphopenia following 1 Gy irradiation. Supplementation with antioxidants in irradiated animals resulted in several gene expression changes: the antioxidant treatment was associated with increased Bcl-2, and decreased Bax, caspase-9 and TGF-β1 mRNA expression in the bone marrow following irradiation. These results suggest that modulation of apoptosis may be mechanistically involved in hematopoietic system radioprotection by antioxidants. Maintenance of the antioxidant diet was associated with improved recovery of the bone marrow following sub-lethal or potentially lethal irradiation. Taken together

  16. NASA Self-Assessment of Space Radiation Research (United States)

    Cucinotta, Francis A.


    Space exploration involves unavoidable exposures to high-energy galactic cosmic rays whose penetration power and associated secondary radiation makes radiation shielding ineffective and cost prohibitive. NASA recognizing the possible health dangers from cosmic rays notified the U.S. Congress as early as 1959 of the need for a dedicated heavy ion accelerator to study the largely unknown biological effects of galactic cosmic rays on astronauts. Information and scientific tools to study radiation health effects expanded over the new decades as NASA exploration programs to the moon and preparations for Mars exploration were carried out. In the 1970 s through the early 1990 s a more than 3-fold increase over earlier estimates of fatal cancer risks from gamma-rays, and new knowledge of the biological dangers of high LET radiation were obtained. Other research has increased concern for degenerative risks to the central nervous system and other tissues at lower doses compared to earlier estimates. In 1996 a review by the National Academy of Sciences Space Science Board re-iterated the need for a dedicated ground-based accelerator facility capable of providing up to 2000 research hours per year to reduce uncertainties in risks projections and develop effective mitigation measures. In 1998 NASA appropriated funds for construction of a dedicated research facility and the NASA Space Radiation Laboratory (NSRL) opened for research in October of 2003. This year marks the 8th year of NSRL research were about 1000 research hours per year have been utilized. In anticipation of the approaching ten year milestone, funded investigators and selected others are invited to participate in a critical self-assessment of NSRL research progress towards NASA s goals in space radiation research. A Blue and Red Team Assessment format has been integrated into meeting posters and special plenary sessions to allow for a critical debate on the progress of the research and major gaps areas. Blue

  17. IR Thermography of International Space Station Radiator Panels (United States)

    Koshti, Ajay; Winfree, WIlliam; Morton, Richard; Howell, Patricia


    Several non-flight qualification test radiators were inspected using flash thermography. Flash thermography data analysis used raw and second derivative images to detect anomalies (Echotherm and Mosaic). Simple contrast evolutions were plotted for the detected anomalies to help in anomaly characterization. Many out-of-family indications were noted. Some out-of-family indications were classified as cold spot indications and are due to additional adhesive or adhesive layer behind the facesheet. Some out-of-family indications were classified as hot spot indications and are due to void, unbond or lack of adhesive behind the facesheet. The IR inspection helped in assessing expected manufacturing quality of the radiators.

  18. Mapping the space radiation environment in LEO orbit by the SATRAM Timepix payload on board the Proba-V satellite

    Energy Technology Data Exchange (ETDEWEB)

    Granja, Carlos, E-mail:; Polansky, Stepan


    Detailed spatial- and time-correlated maps of the space radiation environment in Low Earth Orbit (LEO) are produced by the spacecraft payload SATRAM operating in open space on board the Proba-V satellite from the European Space Agency (ESA). Equipped with the hybrid semiconductor pixel detector Timepix, the compact radiation monitor payload provides the composition and spectral characterization of the mixed radiation field with quantum-counting and imaging dosimetry sensitivity, energetic charged particle tracking, directionality and energy loss response in wide dynamic range in terms of particle types, dose rates and particle fluxes. With a polar orbit (sun synchronous, 98° inclination) at the altitude of 820 km the payload samples the space radiation field at LEO covering basically the whole planet. First results of long-period data evaluation in the form of time-and spatially-correlated maps of total dose rate (all particles) are given.

  19. Hyperspectral imaging from space: Warfighter-1 (United States)

    Cooley, Thomas; Seigel, Gary; Thorsos, Ivan


    The Air Force Research Laboratory Integrated Space Technology Demonstrations (ISTD) Program Office has partnered with Orbital Sciences Corporation (OSC) to complement the commercial satellite's high-resolution panchromatic imaging and Multispectral imaging (MSI) systems with a moderate resolution Hyperspectral imaging (HSI) spectrometer camera. The program is an advanced technology demonstration utilizing a commercially based space capability to provide unique functionality in remote sensing technology. This leveraging of commercial industry to enhance the value of the Warfighter-1 program utilizes the precepts of acquisition reform and is a significant departure from the old-school method of contracting for government managed large demonstration satellites with long development times and technology obsolescence concerns. The HSI system will be able to detect targets from the spectral signature measured by the hyperspectral camera. The Warfighter-1 program will also demonstrate the utility of the spectral information to theater military commanders and intelligence analysts by transmitting HSI data directly to a mobile ground station that receives and processes the data. After a brief history of the project origins, this paper will present the details of the Warfighter-1 system and expected results from exploitation of HSI data as well as the benefits realized by this collaboration between the Air Force and commercial industry.

  20. Space Radar Image of Kliuchevskoi Volcano, Russia (United States)


    This is an image of the Kliuchevskoi volcano, Kamchatka, Russia, which began to erupt on September 30, 1994. Kliuchevskoi is the bright white peak surrounded by red slopes in the lower left portion of the image. The image was acquired by the Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar aboard the space shuttle Endeavour on its 25th orbit on October 1, 1994. The image shows an area approximately 30 kilometers by 60 kilometers (18.5 miles by 37 miles) that is centered at 56.18 degrees north latitude and 160.78 degrees east longitude. North is toward the top of the image. The Kamchatka volcanoes are among the most active volcanoes in the world. The volcanic zone sits above a tectonic plate boundary, where the Pacific plate is sinking beneath the northeast edge of the Eurasian plate. The Endeavour crew obtained dramatic video and photographic images of this region during the eruption, which will assist scientists in analyzing the dynamics of the current activity. The colors in this image were obtained using the following radar channels: red represents the L-band (horizontally transmitted and received); green represents the L-band (horizontally transmitted and vertically received); blue represents the C-band (horizontally transmitted and vertically received). The Kamchatka River runs from left to right across the image. An older, dormant volcanic region appears in green on the north side of the river. The current eruption included massive ejections of gas, vapor and ash, which reached altitudes of 20,000 meters (65,000 feet). New lava flows are visible on the flanks of Kliuchevskoi, appearing yellow/green in the image, superimposed on the red surfaces in the lower center. Melting snow triggered mudflows on the north flank of the volcano, which may threaten agricultural zones and other settlements in the valley to the north. Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars

  1. Space Qualified Heterogeneous Processing Project (United States)

    National Aeronautics and Space Administration — Space Micro proposes to develop a radiation hardened, monolithic, heterogeneous processor for space imaging and radar systems. High performance processors are needed...

  2. Graphene metamaterial modulator for free-space thermal radiation. (United States)

    Fan, Kebin; Suen, Jonathan; Wu, Xueyuan; Padilla, Willie J


    We proposed and demonstrated a new metamaterial architecture capable of high speed modulation of free-space space thermal infrared radiation using graphene. Our design completely eliminates channel resistance, thereby maximizing the electrostatic modulation speed, while at the same time effectively modulating infrared radiation. Experiment results verify that our device with area of 100 × 120 µm2 can achieve a modulation speed as high as 2.6 GHz. We further highlight the utility of our graphene metamaterial modulator by reconstructing a fast infrared signal using an equivalent time sampling technique. The graphene metamaterial modulator demonstrated here is not only limited to the thermal infrared, but may be scaled to longer infrared and terahertz wavelengths. Our work provides a path forward for realization of frequency selective and all-electronic high speed devices for infrared applications.

  3. Anatomical models for space radiation applications: an overview. (United States)

    Atwell, W


    Extremely detailed computerized anatomical male (CAM) and female (CAF) models that have been developed for use in space radiation analyses are discussed and reviewed. Recognizing that the level of detail may currently be inadequate for certain radiological applications, one of the purposes of this paper is to elicit specific model improvements or requirements from the scientific user-community. Methods and rationale are presented which describe the approach used in the Space Shuttle program to extrapolate dosimetry measurements (skin doses) to realistic astronaut body organ doses. Several mission scenarios are presented which demonstrate the utility of the anatomical models for obtaining specific body organ exposure estimates and can be used for establishing cancer morbidity and mortality risk assessments. These exposure estimates are based on the trapped Van Allen belt and galactic cosmic radiation environment models and data from the major historical solar particle events.

  4. Standardization Process for Space Radiation Models Used for Space System Design (United States)

    Barth, Janet; Daly, Eamonn; Brautigam, Donald


    The space system design community has three concerns related to models of the radiation belts and plasma: 1) AP-8 and AE-8 models are not adequate for modern applications; 2) Data that have become available since the creation of AP-8 and AE-8 are not being fully exploited for modeling purposes; 3) When new models are produced, there is no authorizing organization identified to evaluate the models or their datasets for accuracy and robustness. This viewgraph presentation provided an overview of the roadmap adopted by the Working Group Meeting on New Standard Radiation Belt and Space Plasma Models.

  5. Review of nuclear physics experimental data for space radiation. (United States)

    Norbury, John W; Miller, Jack


    The available nuclear fragmentation data relevant to space radiation studies are reviewed. It is found that there are serious gaps in the data. Helium data are missing in the intervals 280 MeV n-3 GeV n and >15 GeV n. Carbon data are missing >15 GeV n. Iron projectile data are missing at all energies except in the interval 280 MeV n-3 GeV n.

  6. Small space object imaging : LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, Mark R.; Valley, Michael T.; Kearney, Sean Patrick


    We report the results of an LDRD effort to investigate new technologies for the identification of small-sized (mm to cm) debris in low-earth orbit. This small-yet-energetic debris presents a threat to the integrity of space-assets worldwide and represents significant security challenge to the international community. We present a nonexhaustive review of recent US and Russian efforts to meet the challenges of debris identification and removal and then provide a detailed description of joint US-Russian plans for sensitive, laser-based imaging of small debris at distances of hundreds of kilometers and relative velocities of several kilometers per second. Plans for the upcoming experimental testing of these imaging schemes are presented and a preliminary path toward system integration is identified.

  7. Space Radiation Analysis for the Mark III Spacesuit (United States)

    Atwell, Bill; Boeder, Paul; Ross, Amy


    NASA has continued the development of space systems by applying and integrating improved technologies that include safety issues, lightweight materials, and electronics. One such area is extravehicular (EVA) spacesuit development with the most recent Mark III spacesuit. In this paper the Mark III spacesuit is discussed in detail that includes the various components that comprise the spacesuit, materials and their chemical composition that make up the spacesuit, and a discussion of the 3-D CAD model of the Mark III spacesuit. In addition, the male (CAM) and female (CAF) computerized anatomical models are also discussed in detail. We combined the spacesuit and the human models, that is, we developed a method of incorporating the human models in the Mark III spacesuit and performed a ray-tracing technique to determine the space radiation shielding distributions for all of the critical body organs. These body organ shielding distributions include the BFO (Blood-Forming Organs), skin, eye, lungs, stomach, and colon, to name a few, for both the male and female. Using models of the trapped (Van Allen) proton and electron environments, radiation exposures were computed for a typical low earth orbit (LEO) EVA mission scenario including the geostationary (GEO) high electron environment. A radiation exposure assessment of these mission scenarios is made to determine whether or not the crew radiation exposure limits are satisfied, and if not, the additional shielding material that would be required to satisfy the crew limits.

  8. Proceedings of the Symposium on the Protection Against Radiation Hazards in Space Book 1: Radiation Environment in Space. Effects of Space Radiation on Radio Sensitive Objects. Biological Effects of Space Radiation (United States)


    The realization in recent years that outer space is traversed by high-energy radiations has caused man to reevaluate the feasibility of manned or even instrumented exploration outside our atmosphere. Fortunately, it is possible to determine the nature and intensities of these radiations and to produce similar radiations on earth by means of accelerators. Thus we can learn how to attenuate them and to design capsules which afford protection against them. Of course this protection carries a weight penalty so that there is a premium on optimizing the shield design. Many groups in the United states are engaged in research to this end,and it was the purpose of this symposium to bring these groups together so that they could exchange information. To make the meeting more comprehensive, sessions on the nature of the radiations and their effects on people and things were included. However, the major part of the meeting was devoted to discussions on shielding research, comprising theoretical calculations and experiments carried out mainly with high-energy accelerators. The symposium committee feels that the aims of the symposium were met and that progress in space research program was greatly accelerated thereby.

  9. Cancer Risks Associated with External Radiation From Diagnostic Imaging Procedures (United States)

    Linet, Martha S.; Slovis, Thomas L.; Miller, Donald L.; Kleinerman, Ruth; Lee, Choonsik; Rajaraman, Preetha; de Gonzalez, Amy Berrington


    The 600% increase in medical radiation exposure to the US population since 1980 has provided immense benefit, but potential future cancer risks to patients. Most of the increase is from diagnostic radiologic procedures. The objectives of this review are to summarize epidemiologic data on cancer risks associated with diagnostic procedures, describe how exposures from recent diagnostic procedures relate to radiation levels linked with cancer occurrence, and propose a framework of strategies to reduce radiation from diagnostic imaging in patients. We briefly review radiation dose definitions, mechanisms of radiation carcinogenesis, key epidemiologic studies of medical and other radiation sources and cancer risks, and dose trends from diagnostic procedures. We describe cancer risks from experimental studies, future projected risks from current imaging procedures, and the potential for higher risks in genetically susceptible populations. To reduce future projected cancers from diagnostic procedures, we advocate widespread use of evidence-based appropriateness criteria for decisions about imaging procedures, oversight of equipment to deliver reliably the minimum radiation required to attain clinical objectives, development of electronic lifetime records of imaging procedures for patients and their physicians, and commitment by medical training programs, professional societies, and radiation protection organizations to educate all stakeholders in reducing radiation from diagnostic procedures. PMID:22307864

  10. Electro-Optical Sensing Apparatus and Method for Characterizing Free-Space Electromagnetic Radiation (United States)

    Zhang, Xi-Cheng; Libelo, Louis Francis; Wu, Qi


    Apparatus and methods for characterizing free-space electromagnetic energy, and in particular, apparatus/method suitable for real-time two-dimensional far-infrared imaging applications are presented. The sensing technique is based on a non-linear coupling between a low-frequency electric field and a laser beam in an electro-optic crystal. In addition to a practical counter-propagating sensing technique, a co-linear approach is described which provides longer radiated field--optical beam interaction length, thereby making imaging applications practical.

  11. NASA Strategy to Safely Live and Work in the Space Radiation Environment (United States)

    Cucinotta, Francis; Wu, Honglu; Corbin, Barbara; Sulzman, Frank; Kreneck, Sam


    This viewgraph document reviews the radiation environment that is a significant potential hazard to NASA's goals for space exploration, of living and working in space. NASA has initiated a Peer reviewed research program that is charged with arriving at an understanding of the space radiation problem. To this end NASA Space Radiation Laboratory (NSRL) was constructed to simulate the harsh cosmic and solar radiation found in space. Another piece of the work was to develop a risk modeling tool that integrates the results from research efforts into models of human risk to reduce uncertainties in predicting risk of carcinogenesis, central nervous system damage, degenerative tissue disease, and acute radiation effects acute radiation effects.

  12. Space Station Validation of Advanced Radiation-Shielding Polymeric Materials Project (United States)

    National Aeronautics and Space Administration — In Subtopic X11.01, NASA has identified the need to develop advanced radiation-shielding materials and systems to protect humans from the hazards of space radiation...

  13. Space Station Validation of Advanced Radiation-Shielding Polymeric Materials Project (United States)

    National Aeronautics and Space Administration — In Subtopic X11-01, NASA has identified the need to develop advanced radiation-shielding materials and systems to protect humans from the hazards of space radiation...

  14. Mitigating radiation damage of single photon detectors for space applications

    Energy Technology Data Exchange (ETDEWEB)

    Anisimova, Elena; Higgins, Brendon L.; Bourgoin, Jean-Philippe [University of Waterloo, Institute for Quantum Computing, Waterloo, ON (Canada); University of Waterloo, Department of Physics and Astronomy, Waterloo, ON (Canada); Cranmer, Miles [University of Waterloo, Institute for Quantum Computing, Waterloo, ON (Canada); Choi, Eric [University of Waterloo, Institute for Quantum Computing, Waterloo, ON (Canada); Magellan Aerospace, Ottawa, ON (Canada); Hudson, Danya; Piche, Louis P.; Scott, Alan [Honeywell Aerospace (formerly COM DEV Ltd.), Ottawa, ON (Canada); Makarov, Vadim [University of Waterloo, Institute for Quantum Computing, Waterloo, ON (Canada); University of Waterloo, Department of Physics and Astronomy, Waterloo, ON (Canada); University of Waterloo, Department of Electrical and Computer Engineering, Waterloo, ON (Canada); Jennewein, Thomas [University of Waterloo, Institute for Quantum Computing, Waterloo, ON (Canada); University of Waterloo, Department of Physics and Astronomy, Waterloo, ON (Canada); Canadian Institute for Advanced Research, Quantum Information Science Program, Toronto, ON (Canada)


    Single-photon detectors in space must retain useful performance characteristics despite being bombarded with sub-atomic particles. Mitigating the effects of this space radiation is vital to enabling new space applications which require high-fidelity single-photon detection. To this end, we conducted proton radiation tests of various models of avalanche photodiodes (APDs) and one model of photomultiplier tube potentially suitable for satellite-based quantum communications. The samples were irradiated with 106 MeV protons at doses approximately equivalent to lifetimes of 0.6, 6, 12 and 24 months in a low-Earth polar orbit. Although most detection properties were preserved, including efficiency, timing jitter and afterpulsing probability, all APD samples demonstrated significant increases in dark count rate (DCR) due to radiation-induced damage, many orders of magnitude higher than the 200 counts per second (cps) required for ground-to-satellite quantum communications. We then successfully demonstrated the mitigation of this DCR degradation through the use of deep cooling, to as low as -86 C. This achieved DCR below the required 200 cps over the 24 months orbit duration. DCR was further reduced by thermal annealing at temperatures of +50 to +100 C. (orig.)

  15. O-space with high resolution readouts outperforms radial imaging. (United States)

    Wang, Haifeng; Tam, Leo; Kopanoglu, Emre; Peters, Dana C; Constable, R Todd; Galiana, Gigi


    While O-Space imaging is well known to accelerate image acquisition beyond traditional Cartesian sampling, its advantages compared to undersampled radial imaging, the linear trajectory most akin to O-Space imaging, have not been detailed. In addition, previous studies have focused on ultrafast imaging with very high acceleration factors and relatively low resolution. The purpose of this work is to directly compare O-Space and radial imaging in their potential to deliver highly undersampled images of high resolution and minimal artifacts, as needed for diagnostic applications. We report that the greatest advantages to O-Space imaging are observed with extended data acquisition readouts. A sampling strategy that uses high resolution readouts is presented and applied to compare the potential of radial and O-Space sequences to generate high resolution images at high undersampling factors. Simulations and phantom studies were performed to investigate whether use of extended readout windows in O-Space imaging would increase k-space sampling and improve image quality, compared to radial imaging. Experimental O-Space images acquired with high resolution readouts show fewer artifacts and greater sharpness than radial imaging with equivalent scan parameters. Radial images taken with longer readouts show stronger undersampling artifacts, which can cause small or subtle image features to disappear. These features are preserved in a comparable O-Space image. High resolution O-Space imaging yields highly undersampled images of high resolution and minimal artifacts. The additional nonlinear gradient field improves image quality beyond conventional radial imaging. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. GCR Simulator Development Status at the NASA Space Radiation Laboratory (United States)

    Slaba, T. C.; Norbury, J. W.; Blattnig, S. R.


    There are large uncertainties connected to the biological response for exposure to galactic cosmic rays (GCR) on long duration deep space missions. In order to reduce the uncertainties and gain understanding about the basic mechanisms through which space radiation initiates cancer and other endpoints, radiobiology experiments are performed with mono-energetic ions beams. Some of the accelerator facilities supporting such experiments have matured to a point where simulating the broad range of particles and energies characteristic of the GCR environment in a single experiment is feasible from a technology, usage, and cost perspective. In this work, several aspects of simulating the GCR environment at the NASA Space Radiation Laboratory (NSRL) are discussed. First, comparisons are made between direct simulation of the external, free space GCR field, and simulation of the induced tissue field behind shielding. It is found that upper energy constraints at NSRL limit the ability to simulate the external, free space field directly (i.e. shielding placed in the beam line in front of a biological target and exposed to a free space spectrum). Second, a reference environment for the GCR simulator and suitable for deep space missions is identified and described in terms of fluence and integrated dosimetric quantities. Analysis results are given to justify the use of a single reference field over a range of shielding conditions and solar activities. Third, an approach for simulating the reference field at NSRL is presented. The approach directly considers the hydrogen and helium energy spectra, and the heavier ions are collectively represented by considering the linear energy transfer (LET) spectrum. While many more aspects of the experimental setup need to be considered before final implementation of the GCR simulator, this preliminary study provides useful information that should aid the final design. Possible drawbacks of the proposed methodology are discussed and weighed

  17. Space Radar Image of Taal Volcano, Philippines (United States)


    This is an image of Taal volcano, near Manila on the island of Luzon in the Philippines. The black area in the center is Taal Lake, which nearly fills the 30-kilometer-diameter (18-mile) caldera. The caldera rim consists of deeply eroded hills and cliffs. The large island in Taal Lake, which itself contains a crater lake, is known as Volcano Island. The bright yellow patch on the southwest side of the island marks the site of an explosion crater that formed during a deadly eruption of Taal in 1965. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on its 78th orbit on October 5, 1994. The image shows an area approximately 56 kilometers by 112 kilometers (34 miles by 68 miles) that is centered at 14.0 degrees north latitude and 121.0 degrees east longitude. North is toward the upper right of the image. The colors in this image were obtained using the following radar channels: red represents the L-band (horizontally transmitted and received); green represents the L-band (horizontally transmitted and vertically received); blue represents the C-band (horizontally transmitted and vertically received). Since 1572, Taal has erupted at least 34 times. Since early 1991, the volcano has been restless, with swarms of earthquakes, new steaming areas, ground fracturing, and increases in water temperature of the lake. Volcanologists and other local authorities are carefully monitoring Taal to understand if the current activity may foretell an eruption. Taal is one of 15 'Decade Volcanoes' that have been identified by the volcanology community as presenting large potential hazards to population centers. The bright area in the upper right of the image is the densely populated city of Manila, only 50 kilometers (30 miles) north of the central crater. Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth

  18. Validity of the Aluminum Equivalent Approximation in Space Radiation Shielding (United States)

    Badavi, Francis F.; Adams, Daniel O.; Wilson, John W.


    The origin of the aluminum equivalent shield approximation in space radiation analysis can be traced back to its roots in the early years of the NASA space programs (Mercury, Gemini and Apollo) wherein the primary radiobiological concern was the intense sources of ionizing radiation causing short term effects which was thought to jeopardize the safety of the crew and hence the mission. Herein, it is shown that the aluminum equivalent shield approximation, although reasonably well suited for that time period and to the application for which it was developed, is of questionable usefulness to the radiobiological concerns of routine space operations of the 21 st century which will include long stays onboard the International Space Station (ISS) and perhaps the moon. This is especially true for a risk based protection system, as appears imminent for deep space exploration where the long-term effects of Galactic Cosmic Ray (GCR) exposure is of primary concern. The present analysis demonstrates that sufficiently large errors in the interior particle environment of a spacecraft result from the use of the aluminum equivalent approximation, and such approximations should be avoided in future astronaut risk estimates. In this study, the aluminum equivalent approximation is evaluated as a means for estimating the particle environment within a spacecraft structure induced by the GCR radiation field. For comparison, the two extremes of the GCR environment, the 1977 solar minimum and the 2001 solar maximum, are considered. These environments are coupled to the Langley Research Center (LaRC) deterministic ionized particle transport code High charge (Z) and Energy TRaNsport (HZETRN), which propagates the GCR spectra for elements with charges (Z) in the range I aluminum equivalent approximation for a good polymeric shield material such as genetic polyethylene (PE). The shield thickness is represented by a 25 g/cm spherical shell. Although one could imagine the progression to greater

  19. Fast radiative transfer modeling for infrared imaging radiometry

    Energy Technology Data Exchange (ETDEWEB)

    Dubuisson, P. [ELICO, Federation de Recherche CNRS 1818, Universite Littoral Cote d' Opale, 32 Av. Foch, 62930 Wimereux (France)]. E-mail:; Giraud, V. [Laboratoire d' Optique Atmospherique, FR1818, Universite de Lille1, 59655 Villeneuve d' Ascq Cedex (France); Chomette, O. [Laboratoire de Meteorologie Dynamique, Ecole Polytechnique, 91128 Palaiseau Cedex (France); Chepfer, H. [Laboratoire de Meteorologie Dynamique, Ecole Polytechnique, 91128 Palaiseau Cedex (France); Pelon, J. [Service d' Aeronomie, Universite Pierre et Marie Curie, 4 Place Jussieu, 75252 Paris Cedex 05 (France)


    Fast radiative transfer codes have been developed for simulating the outgoing radiance (and corresponding brightness temperature) to be measured by the Infrared Imaging Radiometer (IIR) of the space Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) mission. Two simple codes (FASRAD and FASAA), for which scattering is neglected, as well as an accurate code (FASDOM), accounting for scattering and absorption with the Discrete Ordinate Method (DOM), are presented. Their accuracy has been estimated with a reference code including a line-by-line model and the DOM. Simulations have shown that the accuracy is generally better than 0.3K on the brightness temperature for clear or cloudy atmospheres. This accuracy agrees with the expected one of future IIR measurements. In addition, the impact of scattering on the brightness temperature has been evaluated for semi-transparent liquid clouds in the IIR spectral range. Especially, simulations have shown that cloud microphysics retrieval might be possible with the Brightness Temperature Difference (BTD) between two IIR bands, using the couple of wavelengths (8.7-12{mu}m) or (10.6-12{mu}m). However, scattering strongly influences the radiation for shorter wavelengths. The error on the BTD with (8.7-12{mu}m) can reach 4K when scattering is neglected, leading to large uncertainties in the retrieval of droplet effective radius.

  20. Monogroove heat pipe development for the space constructible radiator system (United States)

    Alario, J.; Brown, R.; Kosson, R.


    A high-capacity, high-reliability space radiator is needed in order to satisfy the future heat rejection requirements of large space platforms or space stations. The Space Constructible Radiator (SCR) system is being developed to fill this need. The most important component of the SCR system is the high-capacity monogroove heat pipe which theoretically has a heat transport capacity of 12,700 W-m to 25,400 W-m. This performance represents a better than two order of magnitude increase in transport capacity over currently existing heat pipes. The present investigation is concerned with testing developments which occurred in connection with the monogroove heat pipe during the last two years. A short description of the SCR system is presented, and results are provided for two series of tests which were run on a 15.7-m long heat pipe. The first test series included both performance and diagnostic tests, which pointed to some design modifications which were necessary. The second test series, run on the modified heat pipe, showed improved performance.

  1. On-Line Tool for the Assessment of Radiation in Space - Deep Space Mission Enhancements (United States)

    Sandridge, Chris a.; Blattnig, Steve R.; Norman, Ryan B.; Slaba, Tony C.; Walker, Steve A.; Spangler, Jan L.


    The On-Line Tool for the Assessment of Radiation in Space (OLTARIS, is a web-based set of tools and models that allows engineers and scientists to assess the effects of space radiation on spacecraft, habitats, rovers, and spacesuits. The site is intended to be a design tool for those studying the effects of space radiation for current and future missions as well as a research tool for those developing advanced material and shielding concepts. The tools and models are built around the HZETRN radiation transport code and are primarily focused on human- and electronic-related responses. The focus of this paper is to highlight new capabilities that have been added to support deep space (outside Low Earth Orbit) missions. Specifically, the electron, proton, and heavy ion design environments for the Europa mission have been incorporated along with an efficient coupled electron-photon transport capability to enable the analysis of complicated geometries and slabs exposed to these environments. In addition, a neutron albedo lunar surface environment was also added, that will be of value for the analysis of surface habitats. These updates will be discussed in terms of their implementation and on how OLTARIS can be used by instrument vendors, mission designers, and researchers to analyze their specific requirements.12

  2. SPace Radar Image of Mt. Pinatubo, Philippines (United States)


    This is a false color L-band and C-band image of the area around Mount Pinatubo in the Philippines, centered at about 15 degrees north latitude, 120.5 degrees east longitude. This image was acquired by the Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on orbit 78 on April 13, 1994. The false-color composite is made by displaying the L-band HH return in red, the L-band HV return in green and the C-band HV return in blue. The area shown is approximately 45 by 68 kilometers (28 by 42 miles). The main volcanic crater on Mount Pinatubo produced by the June 1991 eruptions, and the steep slopes on the upper flanks of the volcano, are easily seen in this image. The red color on the high slopes show the rougher ash deposited during the 1991 eruption. The dark drainages are the smooth mudflows which continue to flood the river valleys after heavy rain. Radar images such as this one can be used to identify the areas flooded by mudflows, which are difficult to distinguish visually, and to assess the rate at which the erosion and deposition continues. A key aspect of the second SIR-C/X-SAR mission in August 1994 will be to collect a second image of Pinatubo during the summer monsoon season -- new mudflows will have occurred -- and to evaluate the short-term changes. The 1991 eruption of Mount Pinatubo in the Philippines is well known for its near-global effects on the atmosphere and climate due to the large amount of sulfur dioxide that was injected into the upper atmosphere. What is less widely known is that even today the volcano continues to be a major hazard to the people who have returned to the area around the volcano. Dangerous mudflows (called 'lahars') are often generated by heavy rains, and these can still sweep down river valleys and wash out roads and villages, or bury low lying areas in several meters of mud and volcanic debris. These mudflows will continue to be a severe hazard around Pinatubo for

  3. BioSentinel: Biosensors for Deep-Space Radiation Study (United States)

    Lokugamage, Melissa P.; Santa Maria, Sergio R.; Marina, Diana B.; Bhattacharya, Sharmila


    The BioSentinel mission will be deployed on NASA's Exploration Mission 1 (EM-1) in 2018. We will use the budding yeast, Saccharomyces cerevisiae, as a biosensor to study the effect of deep-space radiation on living cells. The BioSentinel mission will be the first investigation of a biological response to space radiation outside Low Earth Orbit (LEO) in over 40 years. Radiation can cause damage such as double stand breaks (DSBs) on DNA. The yeast cell was chosen for this mission because it is genetically controllable, shares homology with human cells in its DNA repair pathways, and can be stored in a desiccated state for long durations. Three yeast strains will be stored dry in multiple microfluidic cards: a wild type control strain, a mutant defective strain that cannot repair DSBs, and a biosensor strain that can only grow if it gets DSB-and-repair events occurring near a specific gene. Growth and metabolic activity of each strain will be measured by a 3-color LED optical detection system. Parallel experiments will be done on the International Space Station and on Earth so that we can compare the results to that of deep space. One of our main objectives is to characterize the microfluidic card activation sequence before the mission. To increase the sensitivity of yeast cells as biosensors, desiccated yeast in each card will be resuspended in a rehydration buffer. After several weeks, the rehydration buffer will be exchanged with a growth medium in order to measure yeast growth and metabolic activity. We are currently working on a time-course experiment to better understand the effects of the rehydration buffer on the response to ionizing radiation. We will resuspend the dried yeast in our rehydration medium over a period of time; then each week, we will measure the viability and ionizing radiation sensitivity of different yeast strains taken from this rehydration buffer. The data obtained in this study will be useful in finalizing the card activation sequence for

  4. Quantifying radiation safety and quality in medical imaging, part 2: the radiation scorecard. (United States)

    Reiner, Bruce I


    As the utilization of medical imaging services continues to expand, so does the delivery of ionizing radiation. Although recent efforts within the medical imaging community have begun to focus on radiation dose reduction for computed tomography, very few objective data related to radiation dose are currently being prospectively collected, tracked, or analyzed. Without a comprehensive program aimed at objective and reproducible radiation data analysis, ongoing efforts at dose optimization will, in all likelihood, remain marginalized. The proposed radiation scorecard provides an analysis of events within the imaging chain, attempts to involve all stakeholders, and addresses the various technologies being utilized. The combined data can in turn be used for education and training, certification, research, development of best practice guidelines, and new technology development.

  5. Space Radar Image of Altona, Manitoba, Canada (United States)


    This is an X-band seasonal image of the Altona test site in Manitoba, Canada, about 80 kilometers (50 miles) south of Winnipeg. The image is centered at approximately 49 degrees north latitude and 97.5 degrees west longitude. This image was acquired by the Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on April 11, 1994, during the first flight of the radar system, and on October 2, 1994, during the second flight of SIR-C/X-SAR. The image channels have the following color assignments: red represents data acquired on April 11, 1994; green represents data acquired on October 2, 1994; blue represents the ratio of the two data sets. The test site is located in the Red River Basin and is characterized by rich farmland where a variety of crops are grown, including wheat, barley, canola, corn, sunflowers and sugar beets. This SIR-C/X-SAR research site is applying radar remote sensing to study the characteristics of vegetation and soil moisture. The seasonal comparison between the April and October 1994 data show the dramatic differences between surface conditions on the two dates. At the time of the April acquisition, almost all agricultural fields were bare and soil moisture levels were high. In October, however, soils were drier and while most crops had been harvested, some standing vegetation was still present. The areas which are cyan in color are dark in April and bright in October. These represent fields of standing biomass (amount of vegetation in a specified area) and the differences in brightness within these cyan fields represent differences in vegetation type. The very bright fields in October represent standing broadleaf crops such as corn, which had not yet been harvested. Other standing vegetation which has less biomass, such as hay and grain fields, are less bright. The magenta indicates bare soil surfaces which were wetter (brighter) in April than in October. The variations in brightness of

  6. Space Radar Image of Oetzal, Austria (United States)


    This image is a false-color composite of Oetzal, Austria located in the Central Alps centered at 46.8 degrees north latitude, 10.70 degrees east longitude, at the border between Switzerland (top), Italy (left) and Austria (right and bottom). The area shown is 50 kilometers (30 miles) south of Innsbruck, Austria. This image was acquired by the Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on its 14th orbit. Oetztal is a SIR-C/X-SAR hydrology supersite. Approximately one quarter of this image is covered by glaciers, the largest of which, Gepatschferner, is visible as a triangular yellow patch in the center of the scene. The summits of the main peaks reach elevations between 3,500 and 3,768 meters (11,500 and 12,362 feet) above sea level. The tongues of the glaciers are descending from elevated plateaus down into narrow valleys which were formed during the last ice age. This color image was produced in C-band using multi-polarization information (red=CHV, green=CVV,blue=CVV/CHV). The blue areas are lakes (Gepatsch dam at center right; Lake Muta at top right) and glacier ice. The yellow areas are slopes facing the radar and areas of dry snow. Purple corresponds to slopes facing away from the radar. Yellow in the valley bottom corresponds to tree covered areas. There is 30 to 50 centimeters (12 to 20 inches) of dry, fresh snow on the glaciers, and about 10 centimeters (4 inches) in the valley at the city of Vent, Austria (center). At these data were taken, the weather was cold, with snow and thick fog. The entire area would appear white to an optical sensor because it is all covered under a winter snowpack. Researchers are interested in Oetztal because knowing how glaciers shrink and grow over time is an important indication of climatic change. Spaceborne Imaging Radar-C and X-Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth (MTPE). The radars illuminate Earth with

  7. Spatially weighted mutual information image registration for image guided radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Park, Samuel B.; Rhee, Frank C.; Monroe, James I.; Sohn, Jason W. [Department of Radiation Oncology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106 (United States); School of Electrical Engineering and Computer Science, Hanyang University, 1271 Sangrok-gu Sa-3-dong, Ansan, Gyeonggi 426-791 (Korea, Republic of); Medical Physics Services Ltd., 430 Saddlespur Road, Webster Groves, Missouri 63119 (United States); Department of Radiation Oncology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106 (United States)


    Purpose: To develop a new metric for image registration that incorporates the (sub)pixelwise differential importance along spatial location and to demonstrate its application for image guided radiation therapy (IGRT). Methods: It is well known that rigid-body image registration with mutual information is dependent on the size and location of the image subset on which the alignment analysis is based [the designated region of interest (ROI)]. Therefore, careful review and manual adjustments of the resulting registration are frequently necessary. Although there were some investigations of weighted mutual information (WMI), these efforts could not apply the differential importance to a particular spatial location since WMI only applies the weight to the joint histogram space. The authors developed the spatially weighted mutual information (SWMI) metric by incorporating an adaptable weight function with spatial localization into mutual information. SWMI enables the user to apply the selected transform to medically ''important'' areas such as tumors and critical structures, so SWMI is neither dominated by, nor neglects the neighboring structures. Since SWMI can be utilized with any weight function form, the authors presented two examples of weight functions for IGRT application: A Gaussian-shaped weight function (GW) applied to a user-defined location and a structures-of-interest (SOI) based weight function. An image registration example using a synthesized 2D image is presented to illustrate the efficacy of SWMI. The convergence and feasibility of the registration method as applied to clinical imaging is illustrated by fusing a prostate treatment planning CT with a clinical cone beam CT (CBCT) image set acquired for patient alignment. Forty-one trials are run to test the speed of convergence. The authors also applied SWMI registration using two types of weight functions to two head and neck cases and a prostate case with clinically acquired CBCT

  8. Space Radar Image of Raco Biomass Map (United States)


    This biomass map of the Raco, Michigan, area was produced from data acquired by the Spaceborne Imaging Radar C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) onboard space shuttle Endeavour. Biomass is the amount of plant material on an area of Earth's surface. Radar can directly sense the quantity and organizational structure of the woody biomass in the forest. Science team members at the University of Michigan used the radar data to estimate the standing biomass for this Raco site in the Upper Peninsula of Michigan. Detailed surveys of 70 forest stands will be used to assess the accuracy of these techniques. The seasonal growth of terrestrial plants, and forests in particular, leads to the temporary storage of large amounts of carbon, which could directly affect changes in global climate. In order to accurately predict future global change, scientists need detailed information about current distribution of vegetation types and the amount of biomass present around the globe. Optical techniques to determine net biomass are frustrated by chronic cloud-cover. Imaging radar can penetrate through cloud-cover with negligible signal losses. Spaceborne Imaging Radar-C and X-Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground studies, will give scientists clearer insights into those environmental changes which are caused by nature and those changes which are induced by human activity. SIR-C was developed by NASA's Jet Propulsion Laboratory. X-SAR was developed by the Dornier and Alenia Spazio companies for the German

  9. The impact of functional imaging on radiation medicine

    Directory of Open Access Journals (Sweden)

    Macklis Roger


    Full Text Available Abstract Radiation medicine has previously utilized planning methods based primarily on anatomic and volumetric imaging technologies such as CT (Computerized Tomography, ultrasound, and MRI (Magnetic Resonance Imaging. In recent years, it has become apparent that a new dimension of non-invasive imaging studies may hold great promise for expanding the utility and effectiveness of the treatment planning process. Functional imaging such as PET (Positron Emission Tomography studies and other nuclear medicine based assays are beginning to occupy a larger place in the oncology imaging world. Unlike the previously mentioned anatomic imaging methodologies, functional imaging allows differentiation between metabolically dead and dying cells and those which are actively metabolizing. The ability of functional imaging to reproducibly select viable and active cell populations in a non-invasive manner is now undergoing validation for many types of tumor cells. Many histologic subtypes appear amenable to this approach, with impressive sensitivity and selectivity reported. For clinical radiation medicine, the ability to differentiate between different levels and types of metabolic activity allows the possibility of risk based focal treatments in which the radiation doses and fields are more tightly connected to the perceived risk of recurrence or progression at each location. This review will summarize many of the basic principles involved in the field of functional PET imaging for radiation oncology planning and describe some of the major relevant published data behind this expanding trend.

  10. Stochastic Effects in Computational Biology of Space Radiation Cancer Risk (United States)

    Cucinotta, Francis A.; Pluth, Janis; Harper, Jane; O'Neill, Peter


    Estimating risk from space radiation poses important questions on the radiobiology of protons and heavy ions. We are considering systems biology models to study radiation induced repair foci (RIRF) at low doses, in which less than one-track on average transverses the cell, and the subsequent DNA damage processing and signal transduction events. Computational approaches for describing protein regulatory networks coupled to DNA and oxidative damage sites include systems of differential equations, stochastic equations, and Monte-Carlo simulations. We review recent developments in the mathematical description of protein regulatory networks and possible approaches to radiation effects simulation. These include robustness, which states that regulatory networks maintain their functions against external and internal perturbations due to compensating properties of redundancy and molecular feedback controls, and modularity, which leads to general theorems for considering molecules that interact through a regulatory mechanism without exchange of matter leading to a block diagonal reduction of the connecting pathways. Identifying rate-limiting steps, robustness, and modularity in pathways perturbed by radiation damage are shown to be valid techniques for reducing large molecular systems to realistic computer simulations. Other techniques studied are the use of steady-state analysis, and the introduction of composite molecules or rate-constants to represent small collections of reactants. Applications of these techniques to describe spatial and temporal distributions of RIRF and cell populations following low dose irradiation are described.

  11. Photoluminescence in large fluence radiation irradiated space silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Hisamatsu, Tadashi; Kawasaki, Osamu; Matsuda, Sumio [National Space Development Agency of Japan, Tsukuba, Ibaraki (Japan). Tsukuba Space Center; Tsukamoto, Kazuyoshi


    Photoluminescence spectroscopy measurements were carried out for silicon 50{mu}m BSFR space solar cells irradiated with 1MeV electrons with a fluence exceeding 1 x 10{sup 16} e/cm{sup 2} and 10MeV protons with a fluence exceeding 1 x 10{sup 13} p/cm{sup 2}. The results were compared with the previous result performed in a relative low fluence region, and the radiation-induced defects which cause anomalous degradation of the cell performance in such large fluence regions were discussed. As far as we know, this is the first report which presents the PL measurement results at 4.2K of the large fluence radiation irradiated silicon solar cells. (author)

  12. Multi-atlas and unsupervised learning approach to perirectal space segmentation in CT images. (United States)

    Ghose, Soumya; Denham, James W; Ebert, Martin A; Kennedy, Angel; Mitra, Jhimli; Dowling, Jason A


    Perirectal space segmentation in computed tomography images aids in quantifying radiation dose received by healthy tissues and toxicity during the course of radiation therapy treatment of the prostate. Radiation dose normalised by tissue volume facilitates predicting outcomes or possible harmful side effects of radiation therapy treatment. Manual segmentation of the perirectal space is time consuming and challenging in the presence of inter-patient anatomical variability and may suffer from inter- and intra-observer variabilities. However automatic or semi-automatic segmentation of the perirectal space in CT images is a challenging task due to inter patient anatomical variability, contrast variability and imaging artifacts. In the model presented here, a volume of interest is obtained in a multi-atlas based segmentation approach. Un-supervised learning in the volume of interest with a Gaussian-mixture-modeling based clustering approach is adopted to achieve a soft segmentation of the perirectal space. Probabilities from soft clustering are further refined by rigid registration of the multi-atlas mask in a probabilistic domain. A maximum a posteriori approach is adopted to achieve a binary segmentation from the refined probabilities. A mean volume similarity value of 97% and a mean surface difference of 3.06 ± 0.51 mm is achieved in a leave-one-patient-out validation framework with a subset of a clinical trial dataset. Qualitative results show a good approximation of the perirectal space volume compared to the ground truth.

  13. Geometric accuracy in radiation therapy: Dosimetric, imaging and economic considerations (United States)

    Ploquin, Nicolas P.

    In 2007 in Canada, 159,900 men and women will be diagnosed with cancer. Radiation Therapy (RT) is the treatment of cancer by irradiating malignant tissue with ionizing radiation and it is used on up to 50% of all cancers. The objective of radiation therapy is to deliver a lethal dose of radiation to the tumour while sparing the surrounding healthy tissues and organs at risks (OARs). Thus, the accuracy with which the radiation therapy process must be carried out is critical. The presence of setup errors and uncertainties throughout the RT process impacts the dose received by the tumour and OARs and can compromise the outcome for the patient. This thesis focuses on the study of the limiting geometrical accuracy imposed by factors present in radiation therapy process (such as setup errors and uncertainties or the spatial resolution of the imaging systems that we use) and its consequences for the patient. The consequences are quantified through the use of a physical outcome surrogate, the Equivalent Uniform Dose (EUD), which numerically describes the dose distribution received by the target and normal structures surrounding it. A cost-outcome analysis is presented in which the incremental cost of radiation therapy is directly related to the patients outcome (using the EUD) for using various imaging modalities and correction protocols in Image Guided Adaptive Radiation Therapy (IGART).

  14. Radiation Dose Risk and Diagnostic Benefit in Imaging Investigations

    CERN Document Server

    Dobrescu, Lidia


    The paper presents many facets of medical imaging investigations radiological risks. The total volume of prescribed medical investigations proves a serious lack in monitoring and tracking of the cumulative radiation doses in many health services. Modern radiological investigations equipment is continuously reducing the total dose of radiation due to improved technologies, so a decrease in per caput dose can be noticed, but the increasing number of investigations has determined a net increase of the annual collective dose. High doses of radiation are cumulated from Computed Tomography investigations. An integrated system for radiation safety of the patients investigated by radiological imaging methods, based on smart cards and Public Key Infrastructure allow radiation absorbed dose data storage.

  15. Genetic susceptibility: radiation effects relevant to space travel. (United States)

    Peng, Yuanlin; Nagasawa, Hatsumi; Warner, Christy; Bedford, Joel S


    Genetic variation in the capacity to repair radiation damage is an important factor influencing both cellular and tissue radiosensitivity variation among individuals as well as dose rate effects associated with such damage. This paper consists of two parts. The first part reviews some of the available data relating to genetic components governing such variability among individuals in susceptibility to radiation damage relevant for radiation protection and discusses the possibility and extent to which these may also apply for space radiations. The second part focuses on the importance of dose rate effects and genetic-based variations that influence them. Very few dose rate effect studies have been carried out for the kinds of radiations encountered in space. The authors present here new data on the production of chromosomal aberrations in noncycling low passage human ATM+/+ or ATM+/- cells following irradiations with protons (50 MeV or 1 GeV), 1 GeV(-1) n iron ions and gamma rays, where doses were delivered at a high dose rate of 700 mGy(-1) min, or a lower dose rate of 5 mGy min(-1). Dose responses were essentially linear over the dose ranges tested and not significantly different for the two cell strains. Values of the dose rate effectiveness factor (DREF) were expressed as the ratio of the slopes of the dose-response curves for the high versus the lower (5 mGy min(-1)) dose rate exposures. The authors refer to this as the DREF5. For the gamma ray standard, DREF5 values of approximately two were observed. Similar dose rate effects were seen for both energies of protons (DREF5 ≈ 2.2 in both cases). For 1 GeV(-1) n iron ions [linear energy transfer (LET) ≈ 150 keV μ(-1)], the DREF5 was not 1 as might have been expected on the basis of LET alone but was approximately 1.3. From these results and conditions, the authors estimate that the relative biological effectiveness for 1 GeV(-1) n iron ions for high and low dose rates, respectively, were about 10 and 15

  16. A Parallel Tracking Method for Acoustic Radiation Force Impulse Imaging (United States)

    Dahl, Jeremy J.; Pinton, Gianmarco F.; Mark, L; Agrawal, Vineet; Nightingale, Kathryn R.; Trahey, Gregg E.


    Radiation force-based techniques have been developed by several groups for imaging the mechanical properties of tissue. Acoustic Radiation Force Impulse (ARFI) imaging is one such method that uses commercially available scanners to generate localized radiation forces in tissue. The response of the tissue to the radiation force is determined using conventional B-mode imaging pulses to track micron-scale displacements in tissue. Current research in ARFI imaging is focused on producing real-time images of tissue displacements and related mechanical properties. Obstacles to producing a real-time ARFI imaging modality include data acquisition, processing power, data transfer rates, heating of the transducer, and patient safety concerns. We propose a parallel receive beamforming technique to reduce transducer heating and patient acoustic exposure, and to facilitate data acquisition for real-time ARFI imaging. Custom beam sequencing was used with a Siemens SONOLINE AntaresTM scanner to track tissue displacements with parallel-receive beam-forming in tissue-mimicking phantoms. Using simulations, the effects of material properties on parallel tracking are observed. Transducer and tissue heating for parallel tracking are compared to standard ARFI beam sequencing. The effects of tracking beam position and size of the tracked region are also discussed in relation to the size and temporal response of the region of applied force, and the impact on ARFI image contrast and signal-to-noise ratio are quantified. PMID:17328327

  17. Radiation Physics for Space and High Altitude Air Travel (United States)

    Cucinotta, F. A.; Wilson, J. W.; Goldhagen, P.; Saganti, P.; Shavers, M. R.; McKay, Gordon A. (Technical Monitor)


    Galactic cosmic rays (GCR) are of extra-solar origin consisting of high-energy hydrogen, helium, and heavy ions. The GCR are modified by physical processes as they traverse through the solar system, spacecraft shielding, atmospheres, and tissues producing copious amounts of secondary radiation including fragmentation products, neutrons, mesons, and muons. We discuss physical models and measurements relevant for estimating biological risks in space and high-altitude air travel. Ambient and internal spacecraft computational models for the International Space Station and a Mars mission are discussed. Risk assessment is traditionally based on linear addition of components. We discuss alternative models that include stochastic treatments of columnar damage by heavy ion tracks and multi-cellular damage following nuclear fragmentation in tissue.

  18. Electrostatic Discharge Induced in Packaging by Space Radiation (United States)

    Frederickson, A. R.; Nguyen, Tien T.


    Radiation belts around Planets have sufficient high energy electron flux to penetrate spacecraft skins and statically charge insulators inside the electronic boxes. For example, geosynchronous-orbit Earth spacecraft require 100 mils aluminum shielding to sufficiently attenuate the fast electron flux. Electrons are stopped and accumulate slowly in the insulated materials to produce strong electric fields. Typically the field strength achieves a threshold for occasional spontaneous discharge in the insulating material. The field strength remains high yet pulsing is infrequent. Charge can leak off if the insulator is sufficiently leaky. The conductivity of insulators is usually controlled by mobile ions such as H and OH in ground service. In space the mobile ions are eventually out-gassed. The resistivity of several insulators is known to increase over three decades after exposure to vacuum for several months. Insulators in space were seen to pulse more frequently as they aged.

  19. Radiations and space flight; Quand les radiations font partie du voyage

    Energy Technology Data Exchange (ETDEWEB)

    Maalouf, M.; Vogin, G.; Foray, N. [Groupe de Radiobiologie, Inserm U836, Institut des Neurosciences, 38 - Grenoble (France); Maalouf [CNES, Dept. des Sciences de la Vie, 75 - Paris (France); Vogin, G. [Laboratoire de Radiobiologie, EA3738, Faculte de Medecine de Lyon Sud, 69- Oullins (France)


    A space flight is submitted to 3 main sources of radiation: cosmic radiation (4 protons/cm{sup 2}/s and 10000 times less for the heaviest particles), solar radiation (10{sup 8} protons/cm{sup 2}/s in the solar wind), the Van Allen belt around the earth: the magnetosphere traps particles and at an altitude of 500 km the proton flux can reach 100 protons/cm{sup 2}/s. If we take into account all the spatial missions performed since 1960, we get an average dose of 400 {mu}Gray per day with an average dose rate of 0.28 {mu}Gray/mn. A significant risk of radiation-induced cancer is expected for missions whose duration is over 250 days.The cataract appears to be the most likely non-cancerous health hazard due to the exposition to comic radiation. Its risk appears to have been under-estimated, particularly for doses over 8 mGray. Some studies on astronauts have shown for some a very strong predisposition for radio-induced cancers: during the reparation phase of DNA breaking due to irradiation, multiple new damages are added by the cells themselves that behave abnormally. (A.C.)

  20. Space experiment "Cellular Responses to Radiation in Space (CELLRAD)": Hardware and biological system tests (United States)

    Hellweg, Christine E.; Dilruba, Shahana; Adrian, Astrid; Feles, Sebastian; Schmitz, Claudia; Berger, Thomas; Przybyla, Bartos; Briganti, Luca; Franz, Markus; Segerer, Jürgen; Spitta, Luis F.; Henschenmacher, Bernd; Konda, Bikash; Diegeler, Sebastian; Baumstark-Khan, Christa; Panitz, Corinna; Reitz, Günther


    One factor contributing to the high uncertainty in radiation risk assessment for long-term space missions is the insufficient knowledge about possible interactions of radiation with other spaceflight environmental factors. Such factors, e.g. microgravity, have to be considered as possibly additive or even synergistic factors in cancerogenesis. Regarding the effects of microgravity on signal transduction, it cannot be excluded that microgravity alters the cellular response to cosmic radiation, which comprises a complex network of signaling pathways. The purpose of the experiment ;Cellular Responses to Radiation in Space; (CELLRAD, formerly CERASP) is to study the effects of combined exposure to microgravity, radiation and general space flight conditions on mammalian cells, in particular Human Embryonic Kidney (HEK) cells that are stably transfected with different plasmids allowing monitoring of proliferation and the Nuclear Factor κB (NF-κB) pathway by means of fluorescent proteins. The cells will be seeded on ground in multiwell plate units (MPUs), transported to the ISS, and irradiated by an artificial radiation source after an adaptation period at 0 × g and 1 × g. After different incubation periods, the cells will be fixed by pumping a formaldehyde solution into the MPUs. Ground control samples will be treated in the same way. For implementation of CELLRAD in the Biolab on the International Space Station (ISS), tests of the hardware and the biological systems were performed. The sequence of different steps in MPU fabrication (cutting, drilling, cleaning, growth surface coating, and sterilization) was optimized in order to reach full biocompatibility. Different coatings of the foil used as growth surface revealed that coating with 0.1 mg/ml poly-D-lysine supports cell attachment better than collagen type I. The tests of prototype hardware (Science Model) proved its full functionality for automated medium change, irradiation and fixation of cells. Exposure of

  1. Spaceflight Radiation Health program at the Lyndon B. Johnson Space Center (United States)

    Johnson, A. Steve; Badhwar, Gautam D.; Golightly, Michael J.; Hardy, Alva C.; Konradi, Andrei; Yang, Tracy Chui-Hsu


    The Johnson Space Center leads the research and development activities that address the health effects of space radiation exposure to astronaut crews. Increased knowledge of the composition of the environment and of the biological effects of space radiation is required to assess health risks to astronaut crews. The activities at the Johnson Space Center range from quantification of astronaut exposures to fundamental research into the biological effects resulting from exposure to high energy particle radiation. The Spaceflight Radiation Health Program seeks to balance the requirements for operational flexibility with the requirement to minimize crew radiation exposures. The components of the space radiation environment are characterized. Current and future radiation monitoring instrumentation is described. Radiation health risk activities are described for current Shuttle operations and for research development program activities to shape future analysis of health risk.

  2. Space-radiation-induced Photon Luminescence of the Moon (United States)

    Wilson, Thomas; Lee, Kerry


    We report on the results of a study of the photon luminescence of the Moon induced by Galactic Cosmic Rays (GCRs) and space radiation from the Sun, using the Monte Carlo program FLUKA. The model of the lunar surface is taken to be the chemical composition of soils found at various landing sites during the Apollo and Luna programs, averaged over all such sites to define a generic regolith for the present analysis. This then becomes the target that is bombarded by Galactic Cosmic Rays (GCRs) and Solar Energetic Particles (SEPs) above 1 keV in FLUKA to determine the photon fluence albedo produced by the Moon's surface when there is no sunlight and Earthshine. This is to be distinguished from the gamma-ray spectrum produced by the radioactive decay of radiogenic constituents lying in the surface and interior of the Moon. From the photon fluence we derive the spectrum which can be utilized to examine existing lunar spectral data and to design orbiting instrumentation for measuring various components of the space-radiation-induced photon luminescence present on the Moon.

  3. Functional proteomic analysis revealed ground-base ion radiations cannot reflect biological effects of space radiations of rice (United States)

    Wang, Wei; Sun, Yeqing; Zhao, Qian; Han, Lu


    Highly ionizing radiation (HZE) in space is considered as main factor causing biological effects. Radiobiological studies during space flights are unrepeatable due to the variable space radiation environment, ground-base ion radiations are usually performed to simulate of the space biological effect. Spaceflights present a low-dose rate (0.1˜~0.3mGy/day) radiation environment inside aerocrafts while ground-base ion radiations present a much higher dose rate (100˜~500mGy/min). Whether ground-base ion radiation can reflect effects of space radiation is worth of evaluation. In this research, we compared the functional proteomic profiles of rice plants between on-ground simulated HZE particle radiation and spaceflight treatments. Three independent ground-base seed ionizing radiation experiments with different cumulative doses (dose range: 2˜~20000mGy) and different liner energy transfer (LET) values (13.3˜~500keV/μμm) and two independent seed spaceflight experiments onboard Chinese 20th satellite and SZ-6 spacecraft were carried out. Alterations in the proteome were analyzed by two-dimensional difference gel electrophoresis (2-D DIGE) with MALDI-TOF/TOF mass spectrometry identifications. 45 and 59 proteins showed significant (pwork might provide a new evaluation method for further on-ground simulated HZE radiation experiments.

  4. Space Radar Image of Yellowstone Park, Wyoming (United States)


    These two radar images show the majestic Yellowstone National Park, Wyoming, the oldest national park in the United States and home to the world's most spectacular geysers and hot springs. The region supports large populations of grizzly bears, elk and bison. In 1988, the park was burned by one of the most widespread fires to occur in the northern Rocky Mountains in the last 50 years. Surveys indicated that 793,880 acres of land burned. Of that, 41 percent was burned forest, with tree canopies totally consumed by the fire; 35 percent was a combination of unburned, scorched and blackened trees; 13 percent was surface burn under an unburned canopy; 6 percent was non-forest burn; and 5 percent was undifferentiated burn. Six years later, the burned areas are still clearly visible in these false-color radar images obtained by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar on board the space shuttle Endeavour. The image at the left was obtained using the L-band radar channel, horizontally received and vertically transmitted, on the shuttle's 39th orbit on October 2, 1994. The area shown is 45 kilometers by 71 kilometers (28 miles by 44 miles) in size and centered at 44.6 degrees north latitude, 110.7 degrees west longitude. North is toward the top of the image (to the right). Most trees in this area are lodge pole pines at different stages of fire succession. Yellowstone Lake appears as a large dark feature at the bottom of the scene. At right is a map of the forest crown, showing its biomass, or amount of vegetation, which includes foliage and branches. The map was created by inverting SIR-C data and using in situ estimates of crown biomass gathered by the Yellowstone National Biological Survey. The map is displayed on a color scale from blue (rivers and lakes with no biomass) to brown (non-forest areas with crown biomass of less than 4 tons per hectare) to light brown (areas of canopy burn with biomass of between 4 and 12 tons per hectare). Yellow

  5. Human Research Program Space Radiation Standing Review Panel (SRP) (United States)

    Woloschak, Gayle; Steinberg-Wright, S.; Coleman, Norman; Grdina, David; Hill, Colin; Iliakis, George; Metting, Noelle; Meyers, Christina


    The Space Radiation Standing Review Panel (SRP) met at the NASA Johnson Space Center (JSC) on December 9-11, 2009 to discuss the areas of current and future research targeted by the Space Radiation Program Element (SRPE) of the Human Research Program (HRP). Using evidence-based knowledge as a background for identified risks to astronaut health and performance, NASA had identified gaps in knowledge to address those risks. Ongoing and proposed tasks were presented to address the gaps. The charge to the Space Radiation SRP was to review the gaps, evaluate whether the tasks addressed these gaps and to make recommendations to NASA s HRP Science Management Office regarding the SRP's review. The SRP was requested to evaluate the practicality of the proposed efforts in light of the demands placed on the HRP. Several presentations were made to the SRP during the site visit and the SRP spent sufficient time to address the SRP charge. The SRP made a final debriefing to the HRP Program Scientist, Dr. John B. Charles, on December 11, 2009. The SRP noted that current SRPE strategy is properly science-based and views this as the best assurance of the likelihood that answers to the questions posed as gaps in knowledge can be found, that the uncertainty in risk estimates can be reduced, and that a solid, cost-effective approach to risk reduction solutions is being developed. The current approach of the SRPE, based on the use of carefully focused research solicitations, requiring thorough peer-review and approaches demonstrated to be on the path to answering the NASA strategic questions, addressed to a broad extramural community of qualified scientists, optimally positioned to take advantage of serendipitous discoveries and to leverage scientific advances made elsewhere, is sound and appropriate. The SRP viewed with concern statements by HRP implying that the only science legitimately deserving support should be "applied" or, in some instances that the very term "research" might be

  6. Development of Space Life Supporting System Using Radiation Technology (Top Brand Project)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ju Woon; Kim, Jae Hun; Song, Beom Seok; Choi, Jong Il; Yoon, Yo Han; Park, Jin Kyu; Park, Jae Nam; Han, In Jun; Lee, Yoon Jong [KAERI, Daejeon (Korea, Republic of)


    To simulate the space environment of microgravity and expose to space radiation, Hindlimb Suspension Model was established in Gamma Phytotron. Hindlimb suspended group exposed to irradiation, non-suspended group not exposed to irradiation, and non-suspended group exposed to irradiation were experimented for 2 weeks at the dose rate of 3.2 mSV/day. The results showed that muscle weight was decreased by suspension. To develop the countermeasure to physiological changes in space environment, the peptides from soy beam was selected to evaluate the effect with the space environment simulation model. Suing the microscopic and fluorescent images, the growth of microorganisms were detected. The species were identified based on primer-targeted gene sequence analysis. Also, the radiation resistance of species was defined. To research on sustainable nutritional supply and improvement of human physiology in space environment, four kinds of new Korean space foods (Bulgogi, Bibimbap, Seaweed soup, and Mulberry beverage) were developed using the irradiation technology and certified as space foods by the Russian Institute of Biomedical Problems. The contract on joint research of MARS-500 between KAERI and IBMP was made. In the experiment, crews for expedition to Mars will eat Korean space foods (Bulgogi, Bibimbap, Seaweed soup, Mulberry beverage, Kimchi, Sujeonggwa) for 120 days, then their immunity will be examined and compared with it on the ground. The developed technology and know-how could be spun out to the various fields, such as aircraft, automobile, military, information and communication, bio technologies. Moreover, the results obtained from this research can be used for the further development for military use or special food area such as foods for patient

  7. The Use of Radiation Detectors in Medicine: Radiation Detectors for Functional Imaging (2/3)

    CERN Multimedia

    CERN. Geneva


    The development of radiation detectors in the field of nuclear and particle physics has had a terrific impact in medical imaging since this latter discipline took off in late ’70 with the invention of the CT scanners. The massive use in High Energy Physics of position sensitive gas detectors, of high Z and high density scintillators coupled to Photomultiplier (PMT) and Position Sensitive Photomultipliers (PSPMT), and of solid state detectors has triggered during the last 30 years a series of novel applications in Medical Imaging with ionizing radiation. The accelerated scientific progression in genetics and molecular biology has finally generated what it is now called Molecular Imaging. This field of research presents additional challenges not only in the technology of radiation detector, but more and more in the ASIC electronics, fast digital readout and parallel software. In this series of three lectures I will try to present how high energy physics and medical imaging development have both benefited by t...

  8. The Use of Radiation Detectors in Medicine: Radiation Detectors for Morphological Imaging (1/3)

    CERN Multimedia

    CERN. Geneva


    The development of radiation detectors in the field of nuclear and particle physics has had a terrific impact in medical imaging since this latter discipline took off in late ’70 with the invention of the CT scanners. The massive use in High Energy Physics of position sensitive gas detectors, of high Z and high density scintillators coupled to Photomultiplier (PMT) and Position Sensitive Photomultipliers (PSPMT), and of solid state detectors has triggered during the last 30 years a series of novel applications in Medical Imaging with ionizing radiation. The accelerated scientific progression in genetics and molecular biology has finally generated what it is now called Molecular Imaging. This field of research presents additional challenges not only in the technology of radiation detector, but more and more in the ASIC electronics, fast digital readout and parallel software. In this series of three lectures I will try to present how high energy physics and medical imaging development have both benefited by t...

  9. Neurobehavioral Effects of Space Radiation on Psychomotor Vigilance Tests (United States)

    Hienz, Robert; Davis, Catherine; Weed, Michael; Guida, Peter; Gooden, Virginia; Brady, Joseph; Roma, Peter

    Neurobehavioral Effects of Space Radiation on Psychomotor Vigilance Tests INTRODUCTION Risk assessment of the biological consequences of living in the space radiation environment represents one of the highest priority areas of NASA radiation research. Of critical importance is the need for a risk assessment of damage to the central nervous system (CNS) leading to functional cognitive/behavioral changes during long-term space missions, and the development of effective shielding or biological countermeasures to such risks. The present research focuses on the use of an animal model that employs neurobehavioral tests identical or homologous to those currently in use in human models of risk assessment by U.S. agencies such as the Depart-ment of Defense and Federal Aviation and Federal Railroad Administrations for monitoring performance and estimating accident risks associated with such variables as fatigue and/or alcohol or drug abuse. As a first approximation for establishing human risk assessments due to exposure to space radiation, the present work provides animal performance data obtained with the rPVT (rat Psychomotor Vigilance Test), an animal analog of the human PVT that is currently employed for human risk assessments via quantification of sustained attention (e.g., 'vigilance' or 'readiness to perform' tasks). Ground-based studies indicate that radiation can induce neurobehavioral changes in rodents, including impaired performance on motor tasks and deficits in spatial learning and memory. The present study is testing the hypothesis that radiation exposure impairs motor function, performance accuracy, vigilance, motivation, and memory in adult male rats. METHODS The psychomotor vigilance test (PVT) was originally developed as a human cognitive neurobe-havioral assay for tracking the temporally dynamic changes in sustained attention, and has also been used to track changes in circadian rhythm. In humans the test requires responding to a small, bright

  10. Fall 2015 NASA Internship, and Space Radiation Health Project (United States)

    Patience, Luke


    This fall, I was fortunate enough to have been able to participate in an internship at NASA's Lyndon B. Johnson Space Center. I was placed into the Human Health & Performance Directorate, where I was specifically tasked to work with Dr. Zarana Patel, researching the impacts of cosmic level radiation on human cells. Using different laboratory techniques, we were able to examine the cells to see if any damage had been done due to radiation exposure, and if so, how much damage was done. Cell culture samples were exposed at different doses, and fixed at different time points so that we could accumulate a large pool of quantifiable data. After examining quantifiable results relative to the impacts of space radiation on the human body at the cellular and chromosomal level, researchers can defer to different areas of the space program that have to do with astronaut safety, and research and development (extravehicular mobility unit construction, vehicle design and construction, etc.). This experience has been very eye-opening, and I was able to learn quite a bit. I learned some new laboratory techniques, and I did my best to try and learn new ways to balance such a hectic work and school schedule. I also learned some very intimate thing about working at NASA; I learned that far more people want to watch you succeed, rather than watch you fail, and I also learned that this is a place that is alive with innovators and explorers - people who have a sole purpose of exploring space for the betterment of humanity, and not for any other reason. It's truly inspiring. All of these experiences during my internship have impacted me in a really profound way, so much that my educational and career goals are completely different than when I started. I started out as a biotechnology major, and I discovered recently toward the end of the internship, that I don't want to work in a lab, nor was I as enthralled by biological life sciences as a believed myself to be. Taking that all into

  11. Radiation-Tolerant, SpaceWire-Compatible Switching Fabric (United States)

    Katzman, Vladimir


    Current and future near-Earth and deep space exploration programs and space defense programs require the development of robust intra-spacecraft serial data transfer electronics that must be reconfigurable, fault-tolerant, and have the ability to operate effectively for long periods of time in harsh environmental conditions. Existing data transfer systems based on state-of-the-art serial data transfer protocols or passive backplanes are slow, power-hungry, and poorly reconfigurable. They provide limited expandability and poor tolerance to radiation effects and total ionizing dose (TID) in particular, which presents harmful threats to modern submicron electronics. This novel approach is based on a standard library of differential cells tolerant to TID, and patented, multi-level serial interface architecture that ensures the reliable operation of serial interconnects without application of a data-strobe or other encoding techniques. This proprietary, high-speed differential interface presents a lowpower solution fully compatible with the SpaceWire (SW) protocol. It replaces a dual data-strobe link with two identical independent data channels, thus improving the system s tolerance to harsh environments through additional double redundancy. Each channel incorporates an automatic line integrity control circuitry that delivers error signals in case of broken or shorted lines.

  12. A New Active Space Radiation Instruments for the International Space Station, A-DREAMS (United States)

    Uchihori, Yukio; Kodaira, Satoshi; Kitamura, Hisashi; Kobayashi, Shingo

    For future space experiments in the International Space Station (ISS) or other satellites, radiation detectors, A-DREAMS (Active Dosimeter for Radiation Environment and Astronautic Monitoring in Space), using single or multiple silicon semi-conductor detectors have been developed. The first version of the detectors were produced and calibrated with particle accelerators. National Institute of Radiological Sciences has a medical heavy ion accelerator (HIMAC) for cancer therapy and a cyclotron accelerator. The detector was irradiated with high energy heavy ions and protons in HIMAC and the cyclotron and calibrated the energy resolution and linearity for deposited energies of these particles. We are planned to be going to use the new instrument in an international project, the new MATROSHKA experiment which is directed by members in the Institute of Bio-Medical Problem (IBMP) in Russia and German Space Center (DLR) in Germany. In the project, the dose distribution in human torso phantom will be investigated for several months in the ISS. For the project, a new type of the instruments is under development in NIRS and the current situation will be reported in this paper.

  13. Performances of Kevlar and Polyethylene as radiation shielding on-board the International Space Station in high latitude radiation environment. (United States)

    Narici, Livio; Casolino, Marco; Di Fino, Luca; Larosa, Marianna; Picozza, Piergiorgio; Rizzo, Alessandro; Zaconte, Veronica


    Passive radiation shielding is a mandatory element in the design of an integrated solution to mitigate the effects of radiation during long deep space voyages for human exploration. Understanding and exploiting the characteristics of materials suitable for radiation shielding in space flights is, therefore, of primary importance. We present here the results of the first space-test on Kevlar and Polyethylene radiation shielding capabilities including direct measurements of the background baseline (no shield). Measurements are performed on-board of the International Space Station (Columbus modulus) during the ALTEA-shield ESA sponsored program. For the first time the shielding capability of such materials has been tested in a radiation environment similar to the deep-space one, thanks to the feature of the ALTEA system, which allows to select only high latitude orbital tracts of the International Space Station. Polyethylene is widely used for radiation shielding in space and therefore it is an excellent benchmark material to be used in comparative investigations. In this work we show that Kevlar has radiation shielding performances comparable to the Polyethylene ones, reaching a dose rate reduction of 32 ± 2% and a dose equivalent rate reduction of 55 ± 4% (for a shield of 10 g/cm2).

  14. Parameter Study for Optimizing the Mass of a Space Nuclear Power System Radiation Shield

    National Research Council Canada - National Science Library

    Kowash, Benjamin


    A parameter study was conducted for a space nuclear reactor radiation shield. The focus of this research was to explore alternatives to current radiation shield designs to reduce the mass while maintaining the same shielding performance...

  15. 18th International Workshop on Radiation Imaging Detectors

    CERN Document Server


    The International Workshops on Radiation Imaging Detectors are held yearly and provide an international forum for discussing current research and developments in the area of position sensitive detectors for radiation imaging, including semiconductor detectors, gas and scintillator-based detectors. Topics include processing and characterization of detector materials, hybridization and interconnect technologies, design of counting or integrating electronics, readout and data acquisition systems, and applications in various scientific and industrial fields. The workshop will have plenary sessions with invited and contributed papers presented orally and in poster sessions. The invited talks will be chosen to review recent advances in different areas covered in the workshop.

  16. Perspective on space radiation for space flights in 2020-2040 (United States)

    Norbury, John W.


    The Sun undergoes several well known periodicities in activity, such as the Schwabe 11 year cycle, the Gleissberg 80-90 year cycle, the Suess 200-210 year cycle and the Halstatt 2200-2300 year cycle. In addition, there is evidence that the 20th century levels of solar activity are unusually high. The years 2020-2040 are expected to coincide with increased activity in human space flight beyond low Earth orbit. The solar cycles and the present level of solar activity are reviewed and their activities during the years 2020-2040 are discussed with a perspective on space radiation and the future program of space flight. It is prudent to prepare for continuing levels of high solar activity as well as for the low levels of the current deep minimum, which has corresponded to high galactic cosmic ray flux.

  17. Novel biomedical applications of Cerenkov radiation and radioluminescence imaging. (United States)

    Spinelli, Antonello E; Boschi, Federico


    The main goals of this review is to provide an up-to-date account of the different uses of Cerenkov radiation (CR) and radioluminescence imaging for pre-clinical small animal imaging. We will focus on new emerging applications such as the use of Cerenkov imaging for monitoring radionuclide and external radiotherapy in humans. Another novel application that will be described is the monitoring of radiochemical synthesis using microfluidic chips. Several pre-clinical aspects of CR will be discussed such as the development of 3D reconstruction methods for Cerenkov images and the use of CR as excitation source for nanoparticles or for endoscopic imaging. We will also include a discussion on radioluminescence imaging that is a more general method than Cerenkov imaging for the detection using optical methods of alpha and gamma emitters. Copyright © 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  18. Cellular changes in microgravity and the design of space radiation experiments (United States)

    Morrison, D. R.


    Cell metabolism, secretion and cell-cell interactions can be altered during space flight. Early radiobiology experiments have demonstrated synergistic effects of radiation and microgravity as indicated by increased mutagenesis, increased chromosome aberrations, inhibited development, and retarded growth. Microgravity-induced changes in immune cell functions include reduced blastogenesis and cell-mediated, delayed-type hypersensitivity responses, increased cytokine secretions, but inhibited cytotoxic effects an macrophage differentiation. These effects are important because of the high radiosensitivity of immune cells. It is difficult to compare ground studies with space radiation biology experiments because of the complexity of the space radiation environment, types of radiation damage and repair mechanisms. Altered intracellular functions and molecular mechanisms must be considered in the design and interpretation of space radiation experiments. Critical steps in radiocarcinogenesis could be affected. New cell systems and hardware are needed to determine the biological effectiveness of the low dose rate, isotropic, multispectral space radiation and the potential usefulness of radioprotectants during space flight.

  19. Cellular changes in microgravity and the design of space radiation experiments (United States)

    Morrison, D. R.


    Cell metabolism, secretion and cell-cell interactions can be altered during space flight. Early radiobiology experiments have demonstrated synergistic effects of radiation and microgravity as indicated by increased mutagenesis, increased chromosome aberrations, inhibited development, and retarded growth. Microgravity-induced changes in immune cell functions include reduced blastogenesis and cell-mediated, delayed-type hypersensitivity responses, increased cytokine secretions, but inhibited cytotoxic effects and macrophage differentiation. These effecrs are important because of the high radiosensitivity of immune cells. It is difficult to compare ground studies with space radiation biology experiments because of the complexity of the space radiation environment, types of radiation damage and repair mechanisms. Altered intracellular functions and molecular mechanisms must be considered in the design and interpretation of space radiation experiments. Critical steps in radiocarcinogenesis could be affected. New cell systems and hardware are needed to determine the biological effectiveness of the low dose rate, isotropic, multispectral space radiation and the potential usefulness of radioprotectants during space flight.

  20. [The use of image recognition methods in evaluating the degree of severity of radiation injury]. (United States)

    Mkrtchian, R G; Ogandzhanian, E E; Ogandzhanian, A A; Ordukhanian, A A


    The possibility of application of mathematical methods of the image recognition theory for the estimation of radiation damage severity (RDS) is grounded. The application of the method for the RDS estimation according to densito-geometrical parameters of the peripheral blood lymphocytes is described. The decisive rules for the estimation of the RDS within the feature space are developed. The obtained statistically valid linear discriminant functions possess a high descriptive and prognostic power.

  1. Radiation Effects on Emerging Technologies: Implications of Space Weather Risk Management (United States)

    LaBel, Kenneth A.; Barth, Janet L.


    As NASA and its space partners endeavor to develop a network of satellites capable of supporting humankind's needs for advanced space weather prediction and understanding, one of the key challenges is to design a space system to operate in the natural space radiation environment In this paper, we present a description of the natural space radiation environment, the effects of interest to electronic or photonic systems, and a sample of emerging technologies and their specific issues. We conclude with a discussion of operations in the space radiation hazard and considerations for risk management.

  2. Nuclear fragmentation measurements for hadrontherapy and space radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    De Napoli, M. [INFN - Sezione di Catania (Italy); Agodi, C.; Blancato, A. A.; Cavallaro, M.; Cirrone, G. A. P.; Cuttone, G.; Sardina, D.; Scuderi, V. [INFN - Laboratori Nazionali del Sud (Italy); Battistoni, G. [INFN - Sezione di Milano (Italy); Bondi, M.; Cappuzzello, F.; Carbone, D.; Nicolosi, D.; Raciti, G.; Tropea, S. [INFN - Laboratori Nazionali del Sud, Italy and Dipartimento di Fisica e Astronomia, Universita degli Studi di Catania (Italy); Giacoppo, F. [Department of Physics, University of Oslo (Norway); Morone, M. C. [Dipartimento di Biopatologia e Diagnostica per Immagini, Universita di Roma Tor Vergata (Italy); Pandola, L. [INFN-Laboratori Nazionali del Gran Sasso (Italy); Rapisarda, E. [Nuclear and Radiation Physics Section, Katholieke Universiteit Leuven Celestijnenlaan Heverlee (Belgium); Romano, F. [INFN - Laboratori Nazionali del Sud (Italy) and Museo Storico della Fisica e Centro Studi e Ricerche E. Fermi Roma (Italy); and others


    Nuclear fragmentation measurements are necessary in hadrontherapy and space radiation protection, to predict the effects of the ion nuclear interactions within the human body. Nowadays, a very limited set of carbon fragmentation cross sections has been measured and in particular, to our knowledge, no double differential fragmentation cross sections at intermediate energies are available in literature. We have measured the double differential cross sections and the angular distributions of the secondary fragments produced in the {sup 12}C fragmentation at 62 AMeV on a thin carbon target. The experimental data have been also used to benchmark the prediction capability of the Geant4 Monte Carlo code at intermediate energies, where it was never tested before.

  3. Image responses to x-ray radiation in ICCD camera (United States)

    Ma, Jiming; Duan, Baojun; Song, Yan; Song, Guzhou; Han, Changcai; Zhou, Ming; Du, Jiye; Wang, Qunshu; Zhang, Jianqi


    When used in digital radiography, ICCD camera will be inevitably irradiated by x-ray and the output image will degrade. In this research, we separated ICCD camera into two optical-electric parts, CCD camera and MCP image intensifier, and irradiated them respectively on Co-60 gamma ray source and pulsed x-ray source. By changing time association between radiation and the shutter of CCD camera, the state of power supply of MCP image intensifier, significant differences have been observed in output images. A further analysis has revealed the influence of the CCD chip, readout circuit in CCD camera, and the photocathode, microchannel plate and fluorescent screen in MCP image intensifier on image quality of an irradiated ICCD camera. The study demonstrated that compared with other parts, irradiation response of readout circuit is very slight and in most cases negligible. The interaction of x-ray with CCD chip usually behaves as bright spots or rough background in output images, which depends on x-ray doses. As to the MCP image intensifier, photocathode and microchannel plate are the two main steps that degrade output images. When being irradiated by x-ray, microchannel plate in MCP image intensifier tends to contribute a bright background in output images. Background caused by the photocathode looks more bright and fluctuant. Image responses of fluorescent screen in MCP image intensifier in ICCD camera and that of a coupling fiber bundle are also evaluated in this presentation.

  4. Influences of simulated space radiation on optical glasses (United States)

    Doyle, Dominic B.; Czichy, Reinhard H.


    Samples of 20 types of optical glass (both normal and radiation hardened crowns and flints, and fused silica), were subjected to both gamma (Co60) and proton radiation in air to simulate the dose expected over a 10 year lifetime in geostationary orbit. The samples were all 2 mm thick optically flat disks and were characterized before and after irradiation by spectral transmittance (250-800 nm) and wavefront error (approximately 630 nm) measurements. The geometry of the gamma irradiation was such that the outer area of each sample disk was covered by an annular lead shield giving a dose step of 50% of the nominal between the center and edge. This unique configuration gave rise to 'aperture imprinting' in some of the samples after Co60 irradiation, which was manifested as both a visible change in the coloration densities and a clear step in the measured interferograms from center to edge. The spectral transmission properties were much as expected from previously published work, with significant coloration and transmission loss in the near UV and the visible for the non cerium doped samples. The results of the tests are presented in summary form, conclusions are drawn with regard to the selection of optical glasses for application in space borne instrumentation, and recommendations for future work in this field are made.

  5. Space Radiation Shielding Studies for Astronaut and Electronic Component Risk Assessment (United States)

    Fuchs, Jordan Robert


    The dosimetry component of the Center for Radiation Engineering and Science for Space Exploration (CRESSE) will design, develop and characterize the response of a suite of radiation detectors and supporting instrumentation and electronics with three primary goals that will: (1) Use established space radiation detection systems to characterize the primary and secondary radiation fields existing in the experimental test-bed zones during exposures at particle accelerator facilities. (2) Characterize the responses of newly developed space radiation detection systems in the experimental test-bed zones during exposures at particle accelerator facilities, and (3) Provide CRESSE collaborators with detailed dosimetry information in experimental test-bed zones.

  6. A Learning State-Space Model for Image Retrieval

    Directory of Open Access Journals (Sweden)

    Lee Greg C


    Full Text Available This paper proposes an approach based on a state-space model for learning the user concepts in image retrieval. We first design a scheme of region-based image representation based on concept units, which are integrated with different types of feature spaces and with different region scales of image segmentation. The design of the concept units aims at describing similar characteristics at a certain perspective among relevant images. We present the details of our proposed approach based on a state-space model for interactive image retrieval, including likelihood and transition models, and we also describe some experiments that show the efficacy of our proposed model. This work demonstrates the feasibility of using a state-space model to estimate the user intuition in image retrieval.

  7. A novel radiation hard pixel design for space applications (United States)

    Aurora, A. M.; Marochkin, V. V.; Tuuva, T.


    We have developed a novel radiation hard photon detector concept based on Modified Internal Gate Field Effect Transistor (MIGFET) wherein a buried Modified Internal Gate (MIG) is implanted underneath a channel of a FET. In between the MIG and the channel of the FET there is depleted semiconductor material forming a potential barrier between charges in the channel and similar type signal charges located in the MIG. The signal charges in the MIG have a measurable effect on the conductance of the channel. In this paper a radiation hard double MIGFET pixel is investigated comprising two MIGFETs. By transferring the signal charges between the two MIGs Non-Destructive Correlated Double Sampling Readout (NDCDSR) is enabled. The radiation hardness of the proposed double MIGFET structure stems from the fact that interface related issues can be considerably mitigated. The reason for this is, first of all, that interface generated dark noise can be completely avoided and secondly, that interface generated 1/f noise can be considerably reduced due to a deep buried channel readout configuration. Electrical parameters of the double MIGFET pixel have been evaluated by 3D TCAD simulation study. Simulation results show the absence of interface generated dark noise, significantly reduced interface generated 1/f noise, well performing NDCDSR operation, and blooming protection due to an inherent vertical anti-blooming structure. In addition, the backside illuminated thick fully depleted pixel design results in low crosstalk due to lack of diffusion and good quantum efficiency from visible to Near Infra-Red (NIR) light. These facts result in excellent Signal-to-Noise Ratio (SNR) and very low crosstalk enabling thus excellent image quality. The simulation demonstrates the charge to current conversion gain for source current read-out to be 1.4 nA/e.

  8. Space Radiation Effects on Human Cells: Modeling DNA Breakage, DNA Damage Foci Distribution, Chromosomal Aberrations and Tissue Effects (United States)

    Ponomarev, A. L.; Huff, J. L.; Cucinotta, F. A.


    Future long-tem space travel will face challenges from radiation concerns as the space environment poses health risk to humans in space from radiations with high biological efficiency and adverse post-flight long-term effects. Solar particles events may dramatically affect the crew performance, while Galactic Cosmic Rays will induce a chronic exposure to high-linear-energy-transfer (LET) particles. These types of radiation, not present on the ground level, can increase the probability of a fatal cancer later in astronaut life. No feasible shielding is possible from radiation in space, especially for the heavy ion component, as suggested solutions will require a dramatic increase in the mass of the mission. Our research group focuses on fundamental research and strategic analysis leading to better shielding design and to better understanding of the biological mechanisms of radiation damage. We present our recent effort to model DNA damage and tissue damage using computational models based on the physics of heavy ion radiation, DNA structure and DNA damage and repair in human cells. Our particular area of expertise include the clustered DNA damage from high-LET radiation, the visualization of DSBs (DNA double strand breaks) via DNA damage foci, image analysis and the statistics of the foci for different experimental situations, chromosomal aberration formation through DSB misrepair, the kinetics of DSB repair leading to a model-derived spectrum of chromosomal aberrations, and, finally, the simulation of human tissue and the pattern of apoptotic cell damage. This compendium of theoretical and experimental data sheds light on the complex nature of radiation interacting with human DNA, cells and tissues, which can lead to mutagenesis and carcinogenesis later in human life after the space mission.

  9. Meeting the Needs for Radiation Protection: Diagnostic Imaging. (United States)

    Frush, Donald P


    Radiation and potential risk during medical imaging is one of the foremost issues for the imaging community. Because of this, there are growing demands for accountability, including appropriate use of ionizing radiation in diagnostic and image-guided procedures. Factors contributing to this include increasing use of medical imaging; increased scrutiny (from awareness to alarm) by patients/caregivers and the public over radiation risk; and mounting calls for accountability from regulatory, accrediting, healthcare coverage (e.g., Centers for Medicare and Medicaid Services), and advisory agencies and organizations as well as industry (e.g., NEMA XR-29, Standard Attributes on CT Equipment Related to Dose Optimization and Management). Current challenges include debates over uncertainty with risks with low-level radiation; lack of fully developed and targeted products for diagnostic imaging and radiation dose monitoring; lack of resources for and clarity surrounding dose monitoring programs; inconsistencies across and between practices for design, implementation and audit of dose monitoring programs; lack of interdisciplinary programs for radiation protection of patients; potential shortages in personnel for these and other consensus efforts; and training concerns as well as inconsistencies for competencies throughout medical providers' careers for radiation protection of patients. Medical care providers are currently in a purgatory between quality- and value-based imaging paradigms, a state that has yet to mature to reward this move to quality-based performance. There are also deficits in radiation expertise personnel in medicine. For example, health physics academic programs and graduates have recently declined, and medical physics residency openings are currently at a third of the number of graduates. However, leveraging solutions to the medical needs will require money and resources, beyond personnel alone. Energy and capital will need to be directed to

  10. GERMcode: A Stochastic Model for Space Radiation Risk Assessment (United States)

    Kim, Myung-Hee Y.; Ponomarev, Artem L.; Cucinotta, Francis A.


    A new computer model, the GCR Event-based Risk Model code (GERMcode), was developed to describe biophysical events from high-energy protons and high charge and energy (HZE) particles that have been studied at the NASA Space Radiation Laboratory (NSRL) for the purpose of simulating space radiation biological effects. In the GERMcode, the biophysical description of the passage of HZE particles in tissue and shielding materials is made with a stochastic approach that includes both particle track structure and nuclear interactions. The GERMcode accounts for the major nuclear interaction processes of importance for describing heavy ion beams, including nuclear fragmentation, elastic scattering, and knockout-cascade processes by using the quantum multiple scattering fragmentation (QMSFRG) model. The QMSFRG model has been shown to be in excellent agreement with available experimental data for nuclear fragmentation cross sections. For NSRL applications, the GERMcode evaluates a set of biophysical properties, such as the Poisson distribution of particles or delta-ray hits for a given cellular area and particle dose, the radial dose on tissue, and the frequency distribution of energy deposition in a DNA volume. By utilizing the ProE/Fishbowl ray-tracing analysis, the GERMcode will be used as a bi-directional radiation transport model for future spacecraft shielding analysis in support of Mars mission risk assessments. Recent radiobiological experiments suggest the need for new approaches to risk assessment that include time-dependent biological events due to the signaling times for activation and relaxation of biological processes in cells and tissue. Thus, the tracking of the temporal and spatial distribution of events in tissue is a major goal of the GERMcode in support of the simulation of biological processes important in GCR risk assessments. In order to validate our approach, basic radiobiological responses such as cell survival curves, mutation, chromosomal

  11. Batman flies: a compact spectro-imager for space observation (United States)

    Zamkotsian, Frederic; Ilbert, Olivier; Zoubian, Julien; Delsanti, Audrey; Boissier, Samuel; Lancon, Ariane


    from the sky background is blocked. To get more than 2 millions independent micromirrors, the only available component is a Digital Micromirror Device (DMD) chip from Texas Instruments (TI) that features 2048 x 1080 mirrors and a 13.68μm pixel pitch. DMDs have been tested in space environment (-40°C, vacuum, radiations) by LAM and no showstopper has been revealed [7]. We are presenting in this paper a DMD-based spectrograph called BATMAN, including two arms, one spectroscopic channel and one imaging channel. This instrument is designed for getting breakthrough results in several science cases, from high-z galaxies to nearby galaxies and Trans-Neptunian Objects of Kuiper Belt.

  12. Reduction of radiation dose and imaging costs in scoliosis radiography. Application of large-screen image intensifier photofluorography

    Energy Technology Data Exchange (ETDEWEB)

    Manninen, H.; Kiekara, O.; Soimakallio, S.; Vainio, J.


    Photofluorography using a large-field image intensifier (Siemens Optilux 57) was applied to scoliosis radiography and compared with a full-size rare-earth screen/film technique. When scoliosis radiography (PA-projection) was performed on 25 adolescent patients, the photofluorographs were found to be of comparable diagnostic quality with full-size films. A close correspondence between the imaging techniques was found in the Cobb angle measurements as well as in the grading of rotation with the pedicle method. The use of photofluorography results in a radiation dose reduction of about one-half and considerable savings in direct imaging costs and archive space. In our opinion the method is particularly well-suited for follow-up and screening evaluation of scoliosis, but in tall patients the image field size of 40 x 40 cm restricts its usefulness as initial examination.

  13. Image Gently: A campaign to promote radiation protection for ...

    African Journals Online (AJOL)


    Dec 14, 2015 ... developing education materials that support the protection of children worldwide from unnecessary radiation in medicine ... produced open source modules for all stakeholders regarding CT, fluoroscopy, nuclear medicine, interventional radiology ..... Source: Image Gently.

  14. Infrared Radiography: Modeling X-ray Imaging without Harmful Radiation (United States)

    Zietz, Otto; Mylott, Elliot; Widenhorn, Ralf


    Planar x-ray imaging is a ubiquitous diagnostic tool and is routinely performed to diagnose conditions as varied as bone fractures and pneumonia. The underlying principle is that the varying attenuation coefficients of air, water, tissue, bone, or metal implants within the body result in non-uniform transmission of x-ray radiation. Through the…

  15. Safe days in space with acceptable uncertainty from space radiation exposure (United States)

    Cucinotta, Francis A.; Alp, Murat; Rowedder, Blake; Kim, Myung-Hee Y.


    The prediction of the risks of cancer and other late effects from space radiation exposure carries large uncertainties mostly due to the lack of information on the risks from high charge and energy (HZE) particles and other high linear energy transfer (LET) radiation. In our recent work new methods were used to consider NASA's requirement to protect against the acceptable risk of no more than 3% probability of cancer fatality estimated at the 95% confidence level. Because it is not possible that a zero-level of uncertainty could be achieved, we suggest that an acceptable uncertainty level should be defined in relationship to a probability distribution function (PDF) that only suffers from modest skewness with higher uncertainty allowed for a normal PDF. In this paper, we evaluate PDFs and the number or "safe days" in space, which are defined as the mission length where risk limits are not exceeded, for several mission scenarios at different acceptable levels of uncertainty. In addition, we briefly discuss several important issues in risk assessment including non-cancer effects, the distinct tumor spectra and lethality found in animal experiments for HZE particles compared to background or low LET radiation associated tumors, and the possibility of non-targeted effects (NTE) modifying low dose responses and increasing relative biological effectiveness (RBE) factors for tumor induction. Each of these issues skew uncertainty distributions to higher fatality probabilities with the potential to increase central values of risk estimates in the future. Therefore they will require significant research efforts to support space exploration within acceptable levels of risk and uncertainty.

  16. Space Radar Image of Mount Pinatubo Volcano, Philippines (United States)


    These are color composite radar images showing the area around Mount Pinatubo in the Philippines. The images were acquired by the Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on April 14, 1994 (left image) and October 5,1994 (right image). The images are centered at about 15 degrees north latitude and 120.5 degrees east longitude. Both images were obtained with the same viewing geometry. The color composites were made by displaying the L-band (horizontally transmitted and received) in red; the L-band (horizontally transmitted and vertically received) in green; and the C-band (horizontally transmitted and vertically received) in blue. The area shown is approximately 40 kilometers by 65 kilometers (25 miles by 40 miles). The main volcanic crater on Mount Pinatubo produced by the June 1991 eruptions and the steep slopes on the upper flanks of the volcano are easily seen in these images. Red on the high slopes shows the distribution of the ash deposited during the 1991 eruption, which appears red because of the low cross-polarized radar returns at C and L bands. The dark drainages radiating away from the summit are the smooth mudflows, which even three years after the eruptions continue to flood the river valleys after heavy rain. Comparing the two images shows that significant changes have occurred in the intervening five months along the Pasig-Potrero rivers (the dark area in the lower right of the images). Mudflows, called 'lahars,' that occurred during the 1994 monsoon season filled the river valleys, allowing the lahars to spread over the surrounding countryside. Three weeks before the second image was obtained, devastating lahars more than doubled the area affected in the Pasig-Potrero rivers, which is clearly visible as the increase in dark area on the lower right of the images. Migration of deposition to the east (right) has affected many communities. Newly affected areas included the community

  17. Predictions of space radiation fatality risk for exploration missions (United States)

    Cucinotta, Francis A.; To, Khiet; Cacao, Eliedonna


    In this paper we describe revisions to the NASA Space Cancer Risk (NSCR) model focusing on updates to probability distribution functions (PDF) representing the uncertainties in the radiation quality factor (QF) model parameters and the dose and dose-rate reduction effectiveness factor (DDREF). We integrate recent heavy ion data on liver, colorectal, intestinal, lung, and Harderian gland tumors with other data from fission neutron experiments into the model analysis. In an earlier work we introduced distinct QFs for leukemia and solid cancer risk predictions, and here we consider liver cancer risks separately because of the higher RBE's reported in mouse experiments compared to other tumors types, and distinct risk factors for liver cancer for astronauts compared to the U.S. population. The revised model is used to make predictions of fatal cancer and circulatory disease risks for 1-year deep space and International Space Station (ISS) missions, and a 940 day Mars mission. We analyzed the contribution of the various model parameter uncertainties to the overall uncertainty, which shows that the uncertainties in relative biological effectiveness (RBE) factors at high LET due to statistical uncertainties and differences across tissue types and mouse strains are the dominant uncertainty. NASA's exposure limits are approached or exceeded for each mission scenario considered. Two main conclusions are made: 1) Reducing the current estimate of about a 3-fold uncertainty to a 2-fold or lower uncertainty will require much more expansive animal carcinogenesis studies in order to reduce statistical uncertainties and understand tissue, sex and genetic variations. 2) Alternative model assumptions such as non-targeted effects, increased tumor lethality and decreased latency at high LET, and non-cancer mortality risks from circulatory diseases could significantly increase risk estimates to several times higher than the NASA limits.

  18. Imaging using synchrotron radiation for forensic science (United States)

    Cervelli, F.; Carrato, S.; Mattei, A.; Jerian, M.; Benevoli, L.; Mancini, L.; Zanini, F.; Vaccari, L.; Perucchi, A.; Aquilanti, G.


    Forensic science is already taking benefits from synchrotron radiation (SR) sources in trace evidence analysis. In this contribution we show a multi-technique approach to study fingerprints from the morphological and chemical point of view using SR based techniques such as Fourier transform infrared microspectroscopy (FTIRMS), X-ray fluorescence (XRF), X-ray absorption structure (XAS), and phase contrast microradiography. Both uncontaminated and gunshot residue contaminated human fingerprints were deposited on lightly doped silicon wafers and on poly-ethylene-terephthalate foils. For the uncontaminated fingerprints an univariate approach of functional groups mapping to model FT-IRMS data was used to get the morphology and the organic compounds map. For the gunshot residue contaminated fingerprints, after a preliminary elemental analysis using XRF, microradiography just below and above the absorption edge of the elements of interest has been used to map the contaminants within the fingerprint. Finally, XAS allowed us to determine the chemical state of the different elements. The next step will be fusing the above information in order to produce an exhaustive and easily understandable evidence.

  19. Radiation Hardened Nanobridge based Non-volatile Memory for Space Applications Project (United States)

    National Aeronautics and Space Administration — This NASA Phase I SBIR program would develop and demonstrate radiation hardened nanobridge based non-volatile memory (NVM) for space applications. Specifically, we...

  20. Exposure Risks Among Children Undergoing Radiation Therapy: Considerations in the Era of Image Guided Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Hess, Clayton B. [Department of Radiation Oncology, University California Davis Comprehensive Cancer Center, Sacramento, California (United States); Thompson, Holly M. [Department of Diagnostic Radiology, University of California Davis Medical Center, Sacramento, California (United States); Benedict, Stanley H. [Department of Radiation Oncology, University California Davis Comprehensive Cancer Center, Sacramento, California (United States); Seibert, J. Anthony [Department of Diagnostic Radiology, University of California Davis Medical Center, Sacramento, California (United States); Wong, Kenneth [Department of Radiation Oncology, University of California Los Angeles Jonsson Comprehensive Cancer Center, University of California David Geffen School of Medicine, Los Angeles, California (United States); Vaughan, Andrew T. [Department of Radiation Oncology, University California Davis Comprehensive Cancer Center, Sacramento, California (United States); Chen, Allen M., E-mail: [Department of Radiation Oncology, University of California Los Angeles Jonsson Comprehensive Cancer Center, University of California David Geffen School of Medicine, Los Angeles, California (United States)


    Recent improvements in toxicity profiles of pediatric oncology patients are attributable, in part, to advances in the field of radiation oncology such as intensity modulated radiation (IMRT) and proton therapy (IMPT). While IMRT and IMPT deliver highly conformal dose to targeted volumes, they commonly demand the addition of 2- or 3-dimensional imaging for precise positioning—a technique known as image guided radiation therapy (IGRT). In this manuscript we address strategies to further minimize exposure risk in children by reducing effective IGRT dose. Portal X rays and cone beam computed tomography (CBCT) are commonly used to verify patient position during IGRT and, because their relative radiation exposure is far less than the radiation absorbed from therapeutic treatment beams, their sometimes significant contribution to cumulative risk can be easily overlooked. Optimizing the conformality of IMRT/IMPT while simultaneously ignoring IGRT dose may result in organs at risk being exposed to a greater proportion of radiation from IGRT than from therapeutic beams. Over a treatment course, cumulative central-axis CBCT effective dose can approach or supersede the amount of radiation absorbed from a single treatment fraction, a theoretical increase of 3% to 5% in mutagenic risk. In select scenarios, this may result in the underprediction of acute and late toxicity risk (such as azoospermia, ovarian dysfunction, or increased lifetime mutagenic risk) in radiation-sensitive organs and patients. Although dependent on variables such as patient age, gender, weight, body habitus, anatomic location, and dose-toxicity thresholds, modifying IGRT use and acquisition parameters such as frequency, imaging modality, beam energy, current, voltage, rotational degree, collimation, field size, reconstruction algorithm, and documentation can reduce exposure, avoid unnecessary toxicity, and achieve doses as low as reasonably achievable, promoting a culture and practice of “gentle IGRT.”.

  1. Evaluation of the effects of solar radiation on glass. [space environment simulation (United States)

    Firestone, R. F.; Harada, Y.


    The degradation of glass used on space structures due to electromagnetic and particulate radiation in a space environment was evaluated. The space environment was defined and a simulated space exposure apparatus was constructed. Four optical materials were exposed to simulated solar and particulate radiation in a space environment. Sapphire and fused silica experienced little change in transmittance, while optical crown glass and ultra low expansion glass darkened appreciably. Specimen selection and preparation, exposure conditions, and the effect of simulated exposure are discussed. A selective bibliography of the effect of radiation on glass is included.

  2. Space charge dosimeters for extremely low power measurements of radiation in shipping containers (United States)

    Britton, Jr; Charles, L [Alcoa, TN; Buckner, Mark A [Oak Ridge, TN; Hanson, Gregory R [Clinton, TN; Bryan, William L [Knoxville, TN


    Methods and apparatus are described for space charge dosimeters for extremely low power measurements of radiation in shipping containers. A method includes in situ polling a suite of passive integrating ionizing radiation sensors including reading-out dosimetric data from a first passive integrating ionizing radiation sensor and a second passive integrating ionizing radiation sensor, where the first passive integrating ionizing radiation sensor and the second passive integrating ionizing radiation sensor remain situated where the dosimetric data was integrated while reading-out. Another method includes arranging a plurality of ionizing radiation sensors in a spatially dispersed array; determining a relative position of each of the plurality of ionizing radiation sensors to define a volume of interest; collecting ionizing radiation data from at least a subset of the plurality of ionizing radiation sensors; and triggering an alarm condition when a dose level of an ionizing radiation source is calculated to exceed a threshold.

  3. Uniform color spaces and natural image statistics. (United States)

    McDermott, Kyle C; Webster, Michael A


    Many aspects of visual coding have been successfully predicted by starting from the statistics of natural scenes and then asking how the stimulus could be efficiently represented. We started from the representation of color characterized by uniform color spaces, and then asked what type of color environment they implied. These spaces are designed to represent equal perceptual differences in color discrimination or appearance by equal distances in the space. The relative sensitivity to different axes within the space might therefore reflect the gamut of colors in natural scenes. To examine this, we projected perceptually uniform distributions within the Munsell, CIE L(*)u(*)v(*) or CIE L(*)a(*)b(*) spaces into cone-opponent space. All were elongated along a bluish-yellowish axis reflecting covarying signals along the L-M and S-(L+M) cardinal axes, a pattern typical (though not identical) to many natural environments. In turn, color distributions from environments were more uniform when projected into the CIE L(*)a(*)b(*) perceptual space than when represented in a normalized cone-opponent space. These analyses suggest the bluish-yellowish bias in environmental colors might be an important factor shaping chromatic sensitivity, and also suggest that perceptually uniform color metrics could be derived from natural scene statistics and potentially tailored to specific environments. © 2012 Optical Society of America

  4. Acoustic Radiation Force Impulse (ARFI) Imaging-Based Needle Visualization (United States)

    Rotemberg, Veronica; Palmeri, Mark; Rosenzweig, Stephen; Grant, Stuart; Macleod, David; Nightingale, Kathryn


    Ultrasound-guided needle placement is widely used in the clinical setting, particularly for central venous catheter placement, tissue biopsy and regional anesthesia. Difficulties with ultrasound guidance in these areas often result from steep needle insertion angles and spatial offsets between the imaging plane and the needle. Acoustic Radiation Force Impulse (ARFI) imaging leads to improved needle visualization because it uses a standard diagnostic scanner to perform radiation force based elasticity imaging, creating a displacement map that displays tissue stiffness variations. The needle visualization in ARFI images is independent of needle-insertion angle and also extends needle visibility out of plane. Although ARFI images portray needles well, they often do not contain the usual B-mode landmarks. Therefore, a three-step segmentation algorithm has been developed to identify a needle in an ARFI image and overlay the needle prediction on a coregistered B-mode image. The steps are: (1) contrast enhancement by median filtration and Laplacian operator filtration, (2) noise suppression through displacement estimate correlation coefficient thresholding and (3) smoothing by removal of outliers and best-fit line prediction. The algorithm was applied to data sets from horizontal 18, 21 and 25 gauge needles between 0–4 mm offset in elevation from the transducer imaging plane and to 18G needles on the transducer axis (in plane) between 10° and 35° from the horizontal. Needle tips were visualized within 2 mm of their actual position for both horizontal needle orientations up to 1.5 mm off set in elevation from the transducer imaging plane and on-axis angled needles between 10°–35° above the horizontal orientation. We conclude that segmented ARFI images overlaid on matched B-mode images hold promise for improved needle visibility in many clinical applications. PMID:21608445

  5. DICOM and imaging informatics-based radiation therapy (RT) server (United States)

    Law, Maria Y. Y.; Huang, H. K.; Zhang, Xiaoyan; Zhang, Jianguo


    Radiation therapy (RT) is an image intensive treatment. It requires images from projection X-rays, CT, MR, PET for tumor localization, treatment planning and verification of treatment plans. It also needs patient information, images and their processing for tumor localization and dose computation to ensure the delivery of uniform high dose to the target but avoidance of sensitive structures. In these processes, PACS and imaging informatics technologies are used extensively. However, they are not integrated with these technologies as a complete radiation treatment system. Currently RT treatment still relies mostly on tedious manual image and data transfer methods because the community as a whole has not championed the concept of system integration heavily. System integration of RT treatment has many benefits including lower equipment and operation costs, streamline treatment procedures, and better healthcare delivery to the patient. In this paper, we discuss the concept of a DICOM and imaging informatics-based RT server as an attempt to integrate diverse healthcare information systems, imaging modalities and RT equipment into one seamless treatment system.

  6. What Reliability Engineers Should Know about Space Radiation Effects (United States)

    DiBari, Rebecca


    Space radiation in space systems present unique failure modes and considerations for reliability engineers. Radiation effects is not a one size fits all field. Threat conditions that must be addressed for a given mission depend on the mission orbital profile, the technologies of parts used in critical functions and on application considerations, such as supply voltages, temperature, duty cycle, and redundancy. In general, the threats that must be addressed are of two types-the cumulative degradation mechanisms of total ionizing dose (TID) and displacement damage (DD). and the prompt responses of components to ionizing particles (protons and heavy ions) falling under the heading of single-event effects. Generally degradation mechanisms behave like wear-out mechanisms on any active components in a system: Total Ionizing Dose (TID) and Displacement Damage: (1) TID affects all active devices over time. Devices can fail either because of parametric shifts that prevent the device from fulfilling its application or due to device failures where the device stops functioning altogether. Since this failure mode varies from part to part and lot to lot, lot qualification testing with sufficient statistics is vital. Displacement damage failures are caused by the displacement of semiconductor atoms from their lattice positions. As with TID, failures can be either parametric or catastrophic, although parametric degradation is more common for displacement damage. Lot testing is critical not just to assure proper device fi.mctionality throughout the mission. It can also suggest remediation strategies when a device fails. This paper will look at these effects on a variety of devices in a variety of applications. This paper will look at these effects on a variety of devices in a variety of applications. (2) On the NEAR mission a functional failure was traced to a PIN diode failure caused by TID induced high leakage currents. NEAR was able to recover from the failure by reversing the


    Directory of Open Access Journals (Sweden)

    D. S. Korshunov


    Full Text Available The paper deals with an approach for image quality improvement of the space objects in the visible range of electromagnetic wave spectrum. The proposed method is based on the joint taking into account of both the motion velocity of the space supervisory apparatus and a space object observed in the near-earth space when the time of photo-detector exposure is chosen. The timing of exposure is carried out by light-signal characteristics, which determines the optimal value of the charge package formed in the charge-coupled device being irradiated. Thus, the parameters of onboard observation equipment can be selected, which provides space images suitable for interpretation. The linear resolving capacity is used as quality indicator for space images, giving a complete picture for the image contrast and geometric properties of the object on the photo. Observation scenario modeling of the space object, done by sputnik-inspector, has shown the possibility of increasing the linear resolution up to10% - 20% or up to 40% - 50% depending on the non-complanarity angle at the movement along orbits. The proposed approach to the increase of photographs quality provides getting sharp and highcontrast images of space objects by the optical-electronic equipment of the space-based remote sensing. The usage of these images makes it possible to detect in time the space technology failures, which are the result of its exploitation in the nearearth space. The proposed method can be also applied at the stage of space systems design for optical-electronic surveillance in computer models used for facilities assessment of the shooting equipment information tract.

  8. Meeting the Grand Challenge of Protecting Astronaut's Health: Electrostatic Active Space Radiation Shielding for Deep Space Missions Project (United States)

    National Aeronautics and Space Administration — This study will seek to test and validate an electrostatic gossamer structure to provide radiation shielding. It will provide guidelines for energy requirements,...

  9. Monitoring radiation use in cardiac fluoroscopy imaging procedures. (United States)

    Stevens, Nathaniel T; Steiner, Stefan H; Smith, Ian R; MacKay, R Jock


    Timely identification of systematic changes in radiation delivery of an imaging system can lead to a reduction in risk for the patients involved. However, existing quality assurance programs involving the routine testing of equipment performance using phantoms are limited in their ability to effectively carry out this task. To address this issue, the authors propose the implementation of an ongoing monitoring process that utilizes procedural data to identify unexpected large or small radiation exposures for individual patients, as well as to detect persistent changes in the radiation output of imaging platforms. Data used in this study were obtained from records routinely collected during procedures performed in the cardiac catheterization imaging facility at St. Andrew's War Memorial Hospital, Brisbane, Australia, over the period January 2008-March 2010. A two stage monitoring process employing individual and exponentially weighted moving average (EWMA) control charts was developed and used to identify unexpectedly high or low radiation exposure levels for individual patients, as well as detect persistent changes in the radiation output delivered by the imaging systems. To increase sensitivity of the charts, we account for variation in dose area product (DAP) values due to other measured factors (patient weight, fluoroscopy time, and digital acquisition frame count) using multiple linear regression. Control charts are then constructed using the residual values from this linear regression. The proposed monitoring process was evaluated using simulation to model the performance of the process under known conditions. Retrospective application of this technique to actual clinical data identified a number of cases in which the DAP result could be considered unexpected. Most of these, upon review, were attributed to data entry errors. The charts monitoring the overall system radiation output trends demonstrated changes in equipment performance associated with relocation

  10. Radiation: Time, Space and Spirit--Keys to Scientific Literacy Series. (United States)

    Stonebarger, Bill

    This discussion of radiation considers the spectrum of electromagnetic energy including light, x-rays, radioactivity, and other waves. Radiation is considered from three aspects; time, space, and spirit. Time refers to a sense of history; space refers to geography; and spirit refers to life and thought. Several chapters on the history and concepts…

  11. Simulation of transition radiation based beam imaging from tilted targets

    Directory of Open Access Journals (Sweden)

    L. G. Sukhikh


    Full Text Available Transverse beam profile diagnostics in linear electron accelerators is usually based on direct imaging of a beam spot via visible transition radiation. In this case the fundamental resolution limit is determined by radiation diffraction in the optical system. A method to measure beam sizes beyond the diffraction limit is to perform imaging dominated by a single-particle function (SPF, i.e. when the recorded image is dominated not by the transverse beam profile but by the image function of a point source (single electron. Knowledge of the SPF for an experimental setup allows one to extract the transverse beam size from an SPF dominated image. This paper presents an approach that allows one to calculate two-dimensional SPF dominated beam images, taking into account the target inclination angle and the depth-of-field effect. In conclusion, a simple fit function for beam size determination in the case under consideration is proposed and its applicability is tested under various conditions.

  12. Morphological breast imaging: tomography and digital mammography with synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Longo, Renata E-mail:; Pani, Silvia; Arfelli, Fulvia; Dreossi, Diego; Olivo, Alessandro; Poropat, Paolo; Quaia, Emilio; Rigon, Luigi; Zanconati, Fabrizio; Palma, Ludovico Dalla; Castelli, Edoardo


    A synchrotron radiation-based X-ray source offers a powerful tool for mammography due to the energy spectrum properties and the peculiar laminar beam geometry. Significant improvements in image quality have been achieved by the SYRMEP (SYnchrotron Radiation for MEdical Physics) collaboration, which has designed and built a beamline devoted to medical physics at the SR facility Elettra in Trieste (Italy). The detection system developed for digital mammography consists of a silicon pixel detector with 200x300 {mu}m{sup 2} pixel size and high conversion efficiency. The detector is equipped with a low noise read-out electronics working in single photon counting mode. Mammographic phantoms and in vitro full breast samples have been investigated: the digital images show higher contrast resolution and lower absorbed dose than the images of the same samples obtained at the clinical mammographic unit.The SYRMEP collaboration is carrying out a breast tomography feasibility study to evaluate the image quality and the delivered dose. The SYRMEP beam is an ideal tool for tomography due to the laminar and monochromatic beam with negligible divergence. The experimental set-up and the acquisition protocol have been studied and the tomographic images of full breast samples acquired in the energy range 20-28 keV indicate that good quality images can be obtained with delivered doses comparable to conventional mammography.

  13. Radiation length imaging with high-resolution telescopes (United States)

    Stolzenberg, U.; Frey, A.; Schwenker, B.; Wieduwilt, P.; Marinas, C.; Lütticke, F.


    The construction of low mass vertex detectors with a high level of system integration is of great interest for next generation collider experiments. Radiation length images with a sufficient spatial resolution can be used to measure and disentangle complex radiation length X/X0 profiles and contribute to the understanding of vertex detector systems. Test beam experiments with multi GeV particle beams and high-resolution tracking telescopes provide an opportunity to obtain precise 2D images of the radiation length of thin planar objects. At the heart of the X/X0 imaging is a spatially resolved measurement of the scattering angles of particles traversing the object under study. The main challenges are the alignment of the reference telescope and the calibration of its angular resolution. In order to demonstrate the capabilities of X/X0 imaging, a test beam experiment has been conducted. The devices under test were two mechanical prototype modules of the Belle II vertex detector. A data sample of 100 million tracks at 4 GeV has been collected, which is sufficient to resolve complex material profiles on the 30 μm scale.

  14. Strong and ultrastrong coupling with free-space radiation (United States)

    Huppert, S.; Vasanelli, A.; Pegolotti, G.; Todorov, Y.; Sirtori, C.


    Strong and ultrastrong light-matter coupling are remarkable phenomena of quantum electrodynamics occurring when the interaction between matter excitation and an electromagnetic field cannot be described by usual perturbation theory. This is generally achieved by coupling an excitation with large oscillator strength to the confined electromagnetic mode of an optical microcavity. In this work, we demonstrate that strong/ultrastrong coupling can also take place in the absence of optical confinement. We have studied the nonperturbative spontaneous emission of collective excitations in a dense two-dimensional electron gas that superradiantly decays into free space. By using a quantum model based on the input-output formalism, we have derived the linear optical properties of the coupled system, and we demonstrated that its eigenstates are mixed light-matter particles, as in any system displaying strong or ultrastrong light-matter interaction. Moreover, we have shown that in the ultrastrong coupling regime, i.e., when the radiative broadening is comparable to the matter excitation energy, the commonly used rotating-wave and Markov approximations yield unphysical results. Finally, the input-output formalism has allowed us to prove that Kirchhoff's law, describing thermal emission properties, applies to our system in all the light-matter coupling regimes considered in this work.

  15. Multi-image semi-global matching in object space (United States)

    Bethmann, F.; Luhmann, T.


    Semi-Global Matching (SGM) is a widespread algorithm for image matching which is used for very different applications, ranging from real-time applications (e.g. for generating 3D data for driver assistance systems) to aerial image matching. Originally developed for stereo-image matching, several extensions have been proposed to use more than two images within the matching process (multi-baseline matching, multi-view stereo). These extensions still perform the image matching in (rectified) stereo images and combine the pairwise results afterwards to create the final solution. This paper proposes an alternative approach which is suitable for the introduction of an arbitrary number of images into the matching process and utilizes image matching by using non-rectified images. The new method differs from the original SGM method mainly in two aspects: Firstly, the cost calculation is formulated in object space within a dense voxel raster by using the grey (or colour) values of all images instead of pairwise cost calculation in image space. Secondly, the semi-global (path-wise) minimization process is transferred into object space as well, so that the result of semi-global optimization leads to index maps (instead of disparity maps) which directly indicate the 3D positions of the best matches. Altogether, this yields to an essential simplification of the matching process compared to multi-view stereo (MVS) approaches. After a description of the new method, results achieved from two different datasets (close-range and aerial) are presented and discussed.

  16. Exploration Technology Developments Program's Radiation Hardened Electronics for Space Environments (RHESE) Project Overview (United States)

    Keys, Andrew S.; Adams, James H.; Darty, Ronald C.; Patrick, Marshall C.; Johnson, Michael A.; Cressler, John D.


    Primary Objective: 1) A computational tool to accurately predict electronics performance in the presence of space radiation in support of spacecraft design: a) Total dose; b) Single Event Effects; and c) Mean Time Between Failure. (Developed as successor to CR ME96.) Secondary Objectives: 2) To provide a detailed description of the natural radiation environment in support of radiation health and instrument design: a) In deep space; b) Inside the magnetosphere; and c) Behind shielding.

  17. Guiding the Design of Radiation Imagers with Experimentally Benchmarked Geant4 Simulations for Electron-Tracking Compton Imaging (United States)

    Coffer, Amy Beth

    Radiation imagers are import tools in the modern world for a wide range of applications. They span the use-cases of fundamental sciences, astrophysics, medical imaging, all the way to national security, nuclear safeguards, and non-proliferation verification. The type of radiation imagers studied in this thesis were gamma-ray imagers that detect emissions from radioactive materials. Gamma-ray imagers goal is to localize and map the distribution of radiation within their specific field-of-view despite the fact of complicating background radiation that can be terrestrial, astronomical, and temporal. Compton imaging systems are one type of gamma-ray imager that can map the radiation around the system without the use of collimation. Lack of collimation enables the imaging system to be able to detect radiation from all-directions, while at the same time, enables increased detection efficiency by not absorbing incident radiation in non-sensing materials. Each Compton-scatter events within an imaging system generated a possible cone-surface in space that the radiation could have originated from. Compton imaging is limited in its reconstructed image signal-to-background due to these source Compton-cones overlapping with background radiation Compton-cones. These overlapping cones limit Compton imaging's detection-sensitivity in image space. Electron-tracking Compton imaging (ETCI) can improve the detection-sensitivity by measuring the Compton-scattered electron's initial trajectory. With an estimate of the scattered electron's trajectory, one can reduce the Compton-back-projected cone to a cone-arc, thus enabling faster radiation source detection and localization. However, the ability to measure the Compton-scattered electron-trajectories adds another layer of complexity to an already complex methodology. For a real-world imaging applications, improvements are needed in electron-track detection efficiency and in electron-track reconstruction. One way of measuring Compton

  18. Use of discrete chromatic space to tune the image tone in a color image mosaic (United States)

    Zhang, Zuxun; Li, Zhijiang; Zhang, Jianqing; Zheng, Li


    Color image process is a very important problem. However, the main approach presently of them is to transfer RGB colour space into another colour space, such as HIS (Hue, Intensity and Saturation). YIQ, LUV and so on. Virutally, it may not be a valid way to process colour airborne image just in one colour space. Because the electromagnetic wave is physically altered in every wave band, while the color image is perceived based on psychology vision. Therefore, it's necessary to propose an approach accord with physical transformation and psychological perception. Then, an analysis on how to use relative colour spaces to process colour airborne photo is discussed and an application on how to tune the image tone in colour airborne image mosaic is introduced. As a practice, a complete approach to perform the mosaic on color airborne images via taking full advantage of relative color spaces is discussed in the application.

  19. The utility of polarized heliospheric imaging for space weather monitoring. (United States)

    DeForest, C E; Howard, T A; Webb, D F; Davies, J A


    A polarizing heliospheric imager is a critical next generation tool for space weather monitoring and prediction. Heliospheric imagers can track coronal mass ejections (CMEs) as they cross the solar system, using sunlight scattered by electrons in the CME. This tracking has been demonstrated to improve the forecasting of impact probability and arrival time for Earth-directed CMEs. Polarized imaging allows locating CMEs in three dimensions from a single vantage point. Recent advances in heliospheric imaging have demonstrated that a polarized imager is feasible with current component technology.Developing this technology to a high technology readiness level is critical for space weather relevant imaging from either a near-Earth or deep-space mission. In this primarily technical review, we developpreliminary hardware requirements for a space weather polarizing heliospheric imager system and outline possible ways to flight qualify and ultimately deploy the technology operationally on upcoming specific missions. We consider deployment as an instrument on NOAA's Deep Space Climate Observatory follow-on near the Sun-Earth L1 Lagrange point, as a stand-alone constellation of smallsats in low Earth orbit, or as an instrument located at the Sun-Earth L5 Lagrange point. The critical first step is the demonstration of the technology, in either a science or prototype operational mission context.

  20. Space charge effect measurements for a multi-channel ionization chamber used for synchrotron radiation

    Energy Technology Data Exchange (ETDEWEB)

    Nasr, Amgad


    In vivo coronary angiography is one of the techniques used to investigate the heart diseases, by using catheter to inject a contrast medium of a given absorption coefficient into the heart vessels. Taking X-ray images produced by X-ray tube or synchrotron radiation for visualizing the blood in the coronary arteries. As the synchrotron radiation generated by the relativistic charged particle at the bending magnets, which emits high intensity photons in comparison with the X-ray tube. The intensity of the synchrotron radiation is varies with time. However for medical imaging it's necessary to measure the incoming intensity with the integrated time. The thesis work includes building a Multi-channel ionization chamber which can be filled with noble gases N{sub 2}, Ar and Xe with controlled inner pressure up to 30 bar. This affects the better absorption efficiency in measuring the high intensity synchrotron beam fluctuation. The detector is a part of the experimental setup used in the k-edge digital subtraction angiography project, which will be used for correcting the angiography images taken by another detector at the same time. The Multi-channel ionization chamber calibration characteristics are measured using 2 kW X-ray tube with molybdenum anode with characteristic energy of 17.44 keV. According to the fast drift velocity of the electrons relative to the positive ions, the electrons will be collected faster at the anode and will induce current signals, while the positive ions is still drifting towards the cathode. However the accumulation of the slow ions inside the detector disturbs the homogeneous applied electric field and leads to what is known a space charge effect. In this work the space charge effect is measured with very high synchrotron photons intensity from EDR beam line at BESSYII. The strong attenuation in the measured amplitude signal occurs when operating the chamber in the recombination region. A plateau is observed at the amplitude signal when

  1. Multi-sensor radiation detection, imaging, and fusion

    Energy Technology Data Exchange (ETDEWEB)

    Vetter, Kai [Department of Nuclear Engineering, University of California, Berkeley, CA 94720 (United States); Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States)


    Glenn Knoll was one of the leaders in the field of radiation detection and measurements and shaped this field through his outstanding scientific and technical contributions, as a teacher, his personality, and his textbook. His Radiation Detection and Measurement book guided me in my studies and is now the textbook in my classes in the Department of Nuclear Engineering at UC Berkeley. In the spirit of Glenn, I will provide an overview of our activities at the Berkeley Applied Nuclear Physics program reflecting some of the breadth of radiation detection technologies and their applications ranging from fundamental studies in physics to biomedical imaging and to nuclear security. I will conclude with a discussion of our Berkeley Radwatch and Resilient Communities activities as a result of the events at the Dai-ichi nuclear power plant in Fukushima, Japan more than 4 years ago. - Highlights: • .Electron-tracking based gamma-ray momentum reconstruction. • .3D volumetric and 3D scene fusion gamma-ray imaging. • .Nuclear Street View integrates and associates nuclear radiation features with specific objects in the environment. • Institute for Resilient Communities combines science, education, and communities to minimize impact of disastrous events.

  2. Mitigation strategies against radiation-induced background for space astronomy missions (United States)

    Davis, C. S. W.; Hall, D.; Keelan, J.; O'Farrell, J.; Leese, M.; Holland, A.


    The Advanced Telescope for High ENergy Astrophysics (ATHENA) mission is a major upcoming space-based X-ray observatory due to be launched in 2028 by ESA, with the purpose of mapping the early universe and observing black holes. Background radiation is expected to constitute a large fraction of the total system noise in the Wide Field Imager (WFI) instrument on ATHENA, and designing an effective system to reduce the background radiation impacting the WFI will be crucial for maximising its sensitivity. Significant background sources are expected to include high energy protons, X-ray fluorescence lines, 'knock-on' electrons and Compton electrons. Due to the variety of the different background sources, multiple shielding methods may be required to achieve maximum sensitivity in the WFI. These techniques may also be of great interest for use in future space-based X-ray experiments. Simulations have been developed to model the effect of a graded-Z shield on the X-ray fluorescence background. In addition the effect of a 90nm optical blocking filter on the secondary electron background has been investigated and shown to modify the requirements of any secondary electron shielding that is to be used.

  3. Hubble Space Telescope imaging of compact steep spectrum radio sources

    NARCIS (Netherlands)

    deVries, WH; ODea, CP; Baum, SA; Sparks, WB; Biretta, J; deKoff, S; Golombek, D; Lehnert, MD; Macchetto, F; McCarthy, P; Miley, GK

    We present Hubble Space Telescope WFPC2 images taken through a broad red filter (F702W) of 30 Third Cambridge Catalog compact steep spectrum (CSS) radio sources. We have overlaid radio maps taken from the literature on the optical images to determine the radio-optical alignment and to study detailed

  4. Relationship of Personal Space to Body-Image Boundary Definiteness (United States)

    Sanders, Jeffrey L.


    The role of body-image boundary definiteness as a mediating personality variable in interpersonal spatial behavior under conditions of perceived threat was investigated. It was hypothesized that personal space would be positively correlated with body-image boundary definiteness. (Editor)

  5. Characterizing the Radiation Survivability of Space Solar Cell Technologies for Heliospheric Missions (United States)

    Lee, J. H.; Walker, D.; Mann, C. J.; Yue, Y.; Nocerino, J. C.; Smith, B. S.; Mulligan, T.


    Space solar cells are responsible for powering the majority of heliospheric space missions. This paper will discuss methods for characterizing space solar cell technologies for on-orbit operations that rely on a series of laboratory tests that include measuring the solar cells' beginning of life performance under simulated (e.g. AM0 or air mass zero) sunlight over different operating temperatures and observing their end of life performance following exposure to laboratory-generated charged particle radiation (protons and electrons). The Aerospace Corporation operates a proton implanter as well as electron gun facilities and collaborates with external radiation effects facilities to expose space solar cells or other space technologies to representative space radiation environments (i.e. heliosphere or magnetosphere of Earth or other planets), with goals of characterizing how the technologies perform over an anticipated space mission timeline and, through the application of precision diagnostic capabilities, understanding what part of the solar cell is impacted by varying space radiation environments. More recently, Aerospace has been hosting solar cell flight tests on its previously-flown CubeSat avionics bus, providing opportunities to compare the laboratory tests to on-orbit observations. We hope through discussion of the lessons learned and methods we use to characterize how solar cells perform after space radiation exposure that similar methodology could be adopted by others to improve the state of knowledge on the survivability of other space technologies required for future space missions.

  6. Evaluation of SPE and GCR Radiation Effects in Inflatable, Space Suit and Composite Habitat Materials Project (United States)

    Waller, Jess M.; Nichols, Charles


    The radiation resistance of polymeric and composite materials to space radiation is currently based on irradiating materials with Co-60 gamma-radiation to the equivalent total ionizing dose (TID) expected during mission. This is an approximation since gamma-radiation is not truly representative of the particle species; namely, Solar Particle Event (SPE) protons and Galactic Cosmic Ray (GCR) nucleons, encountered in space. In general, the SPE and GCR particle energies are much higher than Co-60 gamma-ray photons, and since the particles have mass, there is a displacement effect due to nuclear collisions between the particle species and the target material. This effort specifically bridges the gap between estimated service lifetimes based on decades old Co-60 gamma-radiation data, and newer assessments of what the service lifetimes actually are based on irradiation with particle species that are more representative of the space radiation environment.

  7. Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit

    Directory of Open Access Journals (Sweden)

    Jeffery C. Chancellor


    Full Text Available Projecting a vision for space radiobiological research necessitates understanding the nature of the space radiation environment and how radiation risks influence mission planning, timelines and operational decisions. Exposure to space radiation increases the risks of astronauts developing cancer, experiencing central nervous system (CNS decrements, exhibiting degenerative tissue effects or developing acute radiation syndrome. One or more of these deleterious health effects could develop during future multi-year space exploration missions beyond low Earth orbit (LEO. Shielding is an effective countermeasure against solar particle events (SPEs, but is ineffective in protecting crew members from the biological impacts of fast moving, highly-charged galactic cosmic radiation (GCR nuclei. Astronauts traveling on a protracted voyage to Mars may be exposed to SPE radiation events, overlaid on a more predictable flux of GCR. Therefore, ground-based research studies employing model organisms seeking to accurately mimic the biological effects of the space radiation environment must concatenate exposures to both proton and heavy ion sources. New techniques in genomics, proteomics, metabolomics and other “omics” areas should also be intelligently employed and correlated with phenotypic observations. This approach will more precisely elucidate the effects of space radiation on human physiology and aid in developing personalized radiological countermeasures for astronauts.

  8. Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit (United States)

    Chancellor, Jeffery C.; Scott, Graham B. I.; Sutton, Jeffrey P.


    Projecting a vision for space radiobiological research necessitates understanding the nature of the space radiation environment and how radiation risks influence mission planning, timelines and operational decisions. Exposure to space radiation increases the risks of astronauts developing cancer, experiencing central nervous system (CNS) decrements, exhibiting degenerative tissue effects or developing acute radiation syndrome. One or more of these deleterious health effects could develop during future multi-year space exploration missions beyond low Earth orbit (LEO). Shielding is an effective countermeasure against solar particle events (SPEs), but is ineffective in protecting crew members from the biological impacts of fast moving, highly-charged galactic cosmic radiation (GCR) nuclei. Astronauts traveling on a protracted voyage to Mars may be exposed to SPE radiation events, overlaid on a more predictable flux of GCR. Therefore, ground-based research studies employing model organisms seeking to accurately mimic the biological effects of the space radiation environment must concatenate exposures to both proton and heavy ion sources. New techniques in genomics, proteomics, metabolomics and other “omics” areas should also be intelligently employed and correlated with phenotypic observations. This approach will more precisely elucidate the effects of space radiation on human physiology and aid in developing personalized radiological countermeasures for astronauts. PMID:25370382

  9. Relaxation in x-space magnetic particle imaging. (United States)

    Croft, Laura R; Goodwill, Patrick W; Conolly, Steven M


    Magnetic particle imaging (MPI) is a new imaging modality that noninvasively images the spatial distribution of superparamagnetic iron oxide nanoparticles (SPIOs). MPI has demonstrated high contrast and zero attenuation with depth, and MPI promises superior safety compared to current angiography methods, X-ray, computed tomography, and magnetic resonance imaging angiography. Nanoparticle relaxation can delay the SPIO magnetization, and in this work we investigate the open problem of the role relaxation plays in MPI scanning and its effect on the image. We begin by amending the x-space theory of MPI to include nanoparticle relaxation effects. We then validate the amended theory with experiments from a Berkeley x-space relaxometer and a Berkeley x-space projection MPI scanner. Our theory and experimental data indicate that relaxation reduces SNR and asymmetrically blurs the image in the scanning direction. While relaxation effects can have deleterious effects on the MPI scan, we show theoretically and experimentally that x-space reconstruction remains robust in the presence of relaxation. Furthermore, the role of relaxation in x-space theory provides guidance as we develop methods to minimize relaxation-induced blurring. This will be an important future area of research for the MPI community.

  10. Performance Analysis on ISAR Imaging of Space Targets

    Directory of Open Access Journals (Sweden)

    Zhou Yejian


    Full Text Available Usually, in traditional Inverse Synthetic Aperture Radar (ISAR systems design and mode selection for space satellite targets, coherent integration gain in azimuth direction hardly can be analyzed, which depends on target’s motion. In this study, we combine the target orbit parameters to determine its motion relative to radar and deduce coherent integration equation in ISAR imaging to realize the selection of imaging intervals based on coherent integration, which can ensure the resolution in azimuth direction. Meanwhile, we analyze the influence of target orbit altitude to echo power and imaging Signal-to-Noise Ratio (SNR that provides a new indicator for space observation ISAR systems design. The result of simulation experiment illustrates that with target orbit altitude increasing, coherent integration gain in azimuth direction of large-angular observation offsets the decreasing of imaging SNR in a degree, which provides a brand-new perspective for space observation ISAR systems and signal processing design.

  11. Investigation of innovative radiation imaging method and system for radiological environments

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, H. [School of Biomedical Engineering, Korea University, Seoul (Korea, Republic of); Joung, J., E-mail: [School of Biomedical Engineering, Korea University, Seoul (Korea, Republic of); Nucare, Inc., Incheon (Korea, Republic of); Kim, Y. [School of Biomedical Engineering, Korea University, Seoul (Korea, Republic of); Nucare, Inc., Incheon (Korea, Republic of); Lee, K. [School of Biomedical Engineering, Korea University, Seoul (Korea, Republic of)


    demonstrated imaging of 3D space, which is the most general and fundamental task in the field of radiological environment imaging. The experiments show quite promising results. In addition, the method is able to provide quantitative information about each distribution, including isotope identification, activity concentration, and the size and shape of radiation sources. Our future studies include employing other detector modules and collimators and developing systems for other applications, such as container truck and conveyor inspections.

  12. Imaging in spinal posterior epidural space lesions: A pictorial essay (United States)

    Gala, Foram B; Aswani, Yashant


    Spinal epidural space is a real anatomic space located outside the dura mater and within the spinal canal extending from foramen magnum to sacrum. Important contents of this space are epidural fat, spinal nerves, epidural veins and arteries. Due to close proximity of posterior epidural space to spinal cord and spinal nerves, the lesions present with symptoms of radiculopathy and/or myelopathy. In this pictorial essay, detailed anatomy of the posterior epidural space, pathologies affecting it along with imaging pearls to accurately diagnose them are discussed. Various pathologies affecting the posterior epidural space either arising from the space itself or occurring secondary to vertebral/intervertebral disc pathologies. Primary spinal bone tumors affecting the posterior epidural space have been excluded. The etiological spectrum affecting the posterior epidural space ranges from degenerative, infective, neoplastic - benign or malignant to miscellaneous pathologies. MRI is the modality of choice in evaluation of these lesions with CT scan mainly helpful in detecting calcification. Due to its excellent soft tissue contrast, Magnetic Resonance Imaging is extremely useful in assessing the pathologies of posterior epidural space, to know their entire extent, characterize them and along with clinical history and laboratory data, arrive at a specific diagnosis and guide the referring clinician. It is important to diagnose these lesions early so as to prevent permanent neurological complication. PMID:27857455

  13. Imaging in spinal posterior epidural space lesions: A pictorial essay

    Directory of Open Access Journals (Sweden)

    Foram B Gala


    Full Text Available Spinal epidural space is a real anatomic space located outside the dura mater and within the spinal canal extending from foramen magnum to sacrum. Important contents of this space are epidural fat, spinal nerves, epidural veins and arteries. Due to close proximity of posterior epidural space to spinal cord and spinal nerves, the lesions present with symptoms of radiculopathy and/or myelopathy. In this pictorial essay, detailed anatomy of the posterior epidural space, pathologies affecting it along with imaging pearls to accurately diagnose them are discussed. Various pathologies affecting the posterior epidural space either arising from the space itself or occurring secondary to vertebral/intervertebral disc pathologies. Primary spinal bone tumors affecting the posterior epidural space have been excluded. The etiological spectrum affecting the posterior epidural space ranges from degenerative, infective, neoplastic - benign or malignant to miscellaneous pathologies. MRI is the modality of choice in evaluation of these lesions with CT scan mainly helpful in detecting calcification. Due to its excellent soft tissue contrast, Magnetic Resonance Imaging is extremely useful in assessing the pathologies of posterior epidural space, to know their entire extent, characterize them and along with clinical history and laboratory data, arrive at a specific diagnosis and guide the referring clinician. It is important to diagnose these lesions early so as to prevent permanent neurological complication.

  14. Imaging in spinal posterior epidural space lesions: A pictorial essay. (United States)

    Gala, Foram B; Aswani, Yashant


    Spinal epidural space is a real anatomic space located outside the dura mater and within the spinal canal extending from foramen magnum to sacrum. Important contents of this space are epidural fat, spinal nerves, epidural veins and arteries. Due to close proximity of posterior epidural space to spinal cord and spinal nerves, the lesions present with symptoms of radiculopathy and/or myelopathy. In this pictorial essay, detailed anatomy of the posterior epidural space, pathologies affecting it along with imaging pearls to accurately diagnose them are discussed. Various pathologies affecting the posterior epidural space either arising from the space itself or occurring secondary to vertebral/intervertebral disc pathologies. Primary spinal bone tumors affecting the posterior epidural space have been excluded. The etiological spectrum affecting the posterior epidural space ranges from degenerative, infective, neoplastic - benign or malignant to miscellaneous pathologies. MRI is the modality of choice in evaluation of these lesions with CT scan mainly helpful in detecting calcification. Due to its excellent soft tissue contrast, Magnetic Resonance Imaging is extremely useful in assessing the pathologies of posterior epidural space, to know their entire extent, characterize them and along with clinical history and laboratory data, arrive at a specific diagnosis and guide the referring clinician. It is important to diagnose these lesions early so as to prevent permanent neurological complication.

  15. Electro-optical and Magneto-optical Sensing Apparatus and Method for Characterizing Free-space Electromagnetic Radiation (United States)

    Zhang, Xi-Cheng; Riordan, Jenifer Ann; Sun, Feng-Guo


    Apparatus and methods for characterizing free-space electromagnetic energy, and in particular, apparatus/method suitable for real-time two-dimensional far-infrared imaging applications are presented. The sensing technique is based on a non-linear coupling between a low-frequency electric (or magnetic) field and a laser beam in an electro-optic (or magnetic-optic) crystal. In addition to a practical counter-propagating sensing technique, a co-linear approach is described which provides longer radiated field-optical beam interaction length, thereby making imaging applications practical.

  16. Effect of scatter on image quality in synchrotron radiation mammography (United States)

    Moeckli, Raphael; Verdun, Francis R.; Fiedler, Stefan; Pachoud, Marc; Schnyder, Pierre; Valley, Jean-Francois


    The display of low-contrast structures and fine microcalcifications is essential for the early diagnosis of breast cancer. In order to achieve a high image quality level with a minimum amount of radiation delivered to the patient, the use of different spectra (Mo or Rh anode and filters) was introduced. The European Synchrotron Radiation Facility is able to produce a monochromatic beam with a high photon flux. It is thus a powerful tool to study the effect of beam energy on image quality and dose in mammography. Our image quality assessment is based on the calculation of the size of the smallest microcalcification detectable on a radiograph, derived from the statistical decision theory. The mean glandular dose is simultaneously measured. Compared with conventional mammography units, the monochromaticity of synchrotron beams improves contrast and the use of a slit instead of an anti-scatter grid leads to a higher primary beam transmission. The relative contribution of these two effects on image quality and dose is discussed.

  17. A Hypothesis on Biological Protection from Space Radiation Through the Use of Therapeutic Gases (United States)

    Schoenfeld, Michael


    This slide presentation proposes a hypothesis to use therapeutic gases in space to enhance the biological protection for astronauts from space radiation. The fundamental role in how radiation causes biological damage appears to be radiolysis, the dissociation of water by radiation. A chain of events appears to cause molecular and biological transformations that ultimately manifest into medical diseases. The hypothesis of this work is that applying medical gases may increase resistance to radiation, by possessing the chemical properties that effectively improve the radical scavenging and enhance bond repair and to induce biological processes which enhance and support natural resistance and repair mechanisms.

  18. Developments in Radiation-Hardened Electronics Applicable to the Vision for Space Exploration (United States)

    Keys, Andrew S.; Frazier, Donald O.; Patrick , Marshall C.; Watson, Michael D.; Johnson, Michael A.; Cressler, John D.; Kolawa, Elizabeth A.


    The Radiation Hardened Electronics for Space Exploration (RHESE) project develops the advanced technologies required to produce radiation hardened electronics, processors, and devices in support of the anticipated requirements of NASA's Constellation program. Methods of protecting and hardening electronics against the encountered space environment are discussed. Critical stages of a spaceflight mission that are vulnerable to radiation-induced interruptions or failures are identified. Solutions to mitigating the risk of radiation events are proposed through the infusion of RHESE technology products and deliverables into the Constellation program's spacecraft designs.

  19. Optical image encryption in phase space (United States)

    Liu, Jun; Xu, Xiaobin; Situ, Guohai; Wu, Quanying


    In the field of optical information security, the research of double random phase encoding is becoming deeper with each passing day, however the encryption system is linear, and the dependencies between plaintext and ciphertext is not complicated, with leaving a great hidden danger to the security of the encryption system. In this paper, we encrypted the higher dimensional Wigner distribution function of low dimensional plaintext by using the bilinear property of Wigner distribution function. Computer simulation results show that this method can not only enlarge the key space, but also break through the linear characteristic of the traditional optical encryption technology. So it can significantly improve the safety of the encryption system.

  20. Radiation Exposure and Mortality from Cardiovascular Disease and Cancer in Early NASA Astronauts: Space for Exploration (United States)

    Elgart, S. R.; Little, M. P.; Campbell, L. J.; Milder, C. M.; Shavers, M. R.; Huff, J. L.; Patel, Z. S.


    Of the many possible health challenges posed during extended exploratory missions to space, the effects of space radiation on cardiovascular disease and cancer are of particular concern. There are unique challenges to estimating those radiation risks; care and appropriate and rigorous methodology should be applied when considering small cohorts such as the NASA astronaut population. The objective of this work was to establish whether there is evidence for excess cardiovascular disease or cancer mortality in an early NASA astronaut cohort and determine if a correlation exists between space radiation exposure and mortality.

  1. Adaptive image denoising using scale and space consistency. (United States)

    Scharcanski, Jacob; Jung, Cláudio R; Clarke, Robin T


    This paper proposes a new method for image denoising with edge preservation, based on image multiresolution decomposition by a redundant wavelet transform. In our approach, edges are implicitly located and preserved in the wavelet domain, whilst image noise is filtered out. At each resolution level, the image edges are estimated by gradient magnitudes (obtained from the wavelet coefficients), which are modeled probabilistically, and a shrinkage function is assembled based on the model obtained. Joint use of space and scale consistency is applied for better preservation of edges. The shrinkage functions are combined to preserve edges that appear simultaneously at several resolutions, and geometric constraints are applied to preserve edges that are not isolated. The proposed technique produces a filtered version of the original image, where homogeneous regions appear separated by well-defined edges. Possible applications include image presegmentation, and image denoising.

  2. X-space MPI: magnetic nanoparticles for safe medical imaging. (United States)

    Goodwill, Patrick William; Saritas, Emine Ulku; Croft, Laura Rose; Kim, Tyson N; Krishnan, Kannan M; Schaffer, David V; Conolly, Steven M


    One quarter of all iodinated contrast X-ray clinical imaging studies are now performed on Chronic Kidney Disease (CKD) patients. Unfortunately, the iodine contrast agent used in X-ray is often toxic to CKD patients' weak kidneys, leading to significant morbidity and mortality. Hence, we are pioneering a new medical imaging method, called Magnetic Particle Imaging (MPI), to replace X-ray and CT iodinated angiography, especially for CKD patients. MPI uses magnetic nanoparticle contrast agents that are much safer than iodine for CKD patients. MPI already offers superb contrast and extraordinary sensitivity. The iron oxide nanoparticle tracers required for MPI are also used in MRI, and some are already approved for human use, but the contrast agents are far more effective at illuminating blood vessels when used in the MPI modality. We have recently developed a systems theoretic framework for MPI called x-space MPI, which has already dramatically improved the speed and robustness of MPI image reconstruction. X-space MPI has allowed us to optimize the hardware for fi ve MPI scanners. Moreover, x-space MPI provides a powerful framework for optimizing the size and magnetic properties of the iron oxide nanoparticle tracers used in MPI. Currently MPI nanoparticles have diameters in the 10-20 nanometer range, enabling millimeter-scale resolution in small animals. X-space MPI theory predicts that larger nanoparticles could enable up to 250 micrometer resolution imaging, which would represent a major breakthrough in safe imaging for CKD patients.

  3. Radiation Hard Space Wire Gigabit Ethernet Compatible Transponder Project (United States)

    National Aeronautics and Space Administration — Current and future programs of near-Earth and deep space exploration performed by NASA and Department of Defense require the development of reconfigurable,...

  4. Radiation-Tolerant, Space Wire-Compatible Switching Fabric Project (United States)

    National Aeronautics and Space Administration — Current and future programs of near-Earth and deep space exploration require the development of faster and more reliable electronics with open system architectures...

  5. Radiation-Tolerant, Space Wire-Compatible Switching Fabric Project (United States)

    National Aeronautics and Space Administration — Current and future programs of near-Earth and deep space exploration require the development of robust serial data transfer electronics within the spacecraft's...

  6. Exploring Sustainability Using images from Space (United States)

    Chen, Loris; Salmon, Jennifer; Burns, Courtney


    , laptops, iPads). As a result, web-based resources are incorporated into student learning on a daily basis. This has created a truly global classroom for students who, via the Internet, can and do access materials from any country in the world. Students work collaboratively using Google Classroom and a suite of Google apps. Teacher-created websites serve as the textbook with text, video, static images, interactive images, and external links designed to stimulate student growth in scientific literacy, language arts, and mathematics. Images of Earth's systems generated from data collected by Earth orbiting spacecraft are essential tools for understanding sustainability concepts at global, national, regional, and local scales. Images and supporting data from NASA (U.S.), ESA (Europe), and JAXA (Japan) are used to explore Earth's atmosphere, hydrosphere, and geosphere. Simulations, time-lapses, and graphical representations of historical and real-time, remote-sensing data stimulate student questions and engage students in learning as they design and test models to explain complex interactions of Earth's systems and feedback loops between natural and human-made environments. As students make meaning of observations and communicate their perceptions and understandings to a variety of audiences, they gain mastery of scientific literacy, language arts skills, and mathematics skills.

  7. Image-guided radiation therapy for treatment delivery and verification (United States)

    Schubert, Leah Kayomi

    Target conformity and normal tissue sparing provided by modern radiation therapy techniques often result in steep dose gradients, which increase the need for more accurate patient setup and treatment delivery. Image guidance is starting to play a major role in determining the accuracy of treatment setup. A typical objective of image-guided radiation therapy (IGRT) is to minimize differences between planned and delivered treatment by imaging the patient prior to delivery. This step verifies and corrects for patient setup and is referred to as setup verification. This dissertation evaluates the efficacy of daily imaging for setup verification and investigates new uses of IGRT for potential improvements in treatment delivery. The necessity of daily imaging can first be determined by assessing differences in setup corrections between patient groups. Therefore, the first objective of this investigation was to evaluate the application of IGRT for setup verification by quantifying differences in patient positioning for several anatomical disease sites. Detailed analysis of setup corrections for brain, head and neck, lung, and prostate treatments is presented. In this analysis, large setup errors were observed for prostate treatments. Further assessment of prostate treatments was performed, and patient-specific causes of setup errors investigated. Setup corrections are applied via rigid shifts or rotations of the patient or machine, but anatomical deformations occur for which rigid shifts cannot correct. Fortunately, IGRT provides images on which anatomical changes occurring throughout the course of treatment can be detected. From those images, the efficacy of IGRT in ensuring accurate treatment delivery can be evaluated and improved by determining delivered doses and adapting the plan during treatment. The second objective of this dissertation was to explore new applications of IGRT to further improve treatment. By utilizing daily IGRT images, a retrospective analysis of

  8. The HERMES dual-radiator ring imaging Cherenkov detector

    CERN Document Server

    Akopov, N; Bailey, K; Bernreuther, S; Bianchi, N; Capitani, G P; Carter, P; Cisbani, E; De Leo, R; De Sanctis, E; De Schepper, D; Dzhordzhadze, V; Filippone, B W; Frullani, S; Garibaldi, F; Hansen, J O; Hommez, B; Iodice, M; Jackson, H E; Jung, P; Kaiser, R; Kanesaka, J; Kowalczyk, R; Lagamba, L; Maas, A; Muccifora, V; Nappi, E; Negodaeva, K; Nowak, Wolf-Dieter; O'Connor, T; O'Neill, T G; Potterveld, D H; Ryckbosch, D; Sakemi, Y; Sato, F; Schwind, A; Shibata, T A; Suetsugu, K; Thomas, E; Tytgat, M; Urciuoli, G M; Van De Kerckhove, K; Van De Vyver, R; Yoneyama, S; Zhang, L F; Zohrabyan, H G


    The construction and use of a dual radiator Ring Imaging Cherenkov (RICH) detector is described. This instrument was developed for the HERMES experiment at DESY which emphasises measurements of semi-inclusive deep-inelastic scattering. It provides particle identification for pions, kaons, and protons in the momentum range from 2 to 15 GeV, which is essential to these studies. The instrument uses two radiators, C sub 4 F sub 1 sub 0 , a heavy fluorocarbon gas, and a wall of silica aerogel tiles. The use of aerogel in a RICH detector has only recently become possible with the development of clear, large, homogeneous and hydrophobic aerogel. A lightweight mirror was constructed using a newly perfected technique to make resin-coated carbon-fiber surfaces of optical quality. The photon detector consists of 1934 photomultiplier tubes (PMT) for each detector half, held in a soft steel matrix to provide shielding against the residual field of the main spectrometer magnet.

  9. Radiation dose and image quality for paediatric interventional cardiology

    Energy Technology Data Exchange (ETDEWEB)

    Vano, E [Radiology Department, Medicine School, Complutense University and San Carlos University Hospital, 28040 Madrid (Spain); Ubeda, C [Clinical Sciences Department, Faculty of the Science of Health, Tarapaca University, 18 de Septiembre 2222, Arica (Chile); Leyton, F [Institute of Public Health of Chile, Marathon 1000, Nunoa, Santiago (Chile); Miranda, P [Hemodynamic Department, Cardiovascular Service, Luis Calvo Mackenna Hospital, Avenida Antonio Varas 360, Providencia, Santiago (Chile)], E-mail:


    Radiation dose and image quality for paediatric protocols in a biplane x-ray system used for interventional cardiology have been evaluated. Entrance surface air kerma (ESAK) and image quality using a test object and polymethyl methacrylate (PMMA) phantoms have been measured for the typical paediatric patient thicknesses (4-20 cm of PMMA). Images from fluoroscopy (low, medium and high) and cine modes have been archived in digital imaging and communications in medicine (DICOM) format. Signal-to-noise ratio (SNR), figure of merit (FOM), contrast (CO), contrast-to-noise ratio (CNR) and high contrast spatial resolution (HCSR) have been computed from the images. Data on dose transferred to the DICOM header have been used to test the values of the dosimetric display at the interventional reference point. ESAK for fluoroscopy modes ranges from 0.15 to 36.60 {mu}Gy/frame when moving from 4 to 20 cm PMMA. For cine, these values range from 2.80 to 161.10 {mu}Gy/frame. SNR, FOM, CO, CNR and HCSR are improved for high fluoroscopy and cine modes and maintained roughly constant for the different thicknesses. Cumulative dose at the interventional reference point resulted 25-45% higher than the skin dose for the vertical C-arm (depending of the phantom thickness). ESAK and numerical image quality parameters allow the verification of the proper setting of the x-ray system. Knowing the increases in dose per frame when increasing phantom thicknesses together with the image quality parameters will help cardiologists in the good management of patient dose and allow them to select the best imaging acquisition mode during clinical procedures.

  10. Source-space ICA for MEG source imaging. (United States)

    Jonmohamadi, Yaqub; Jones, Richard D


    One of the most widely used approaches in electroencephalography/magnetoencephalography (MEG) source imaging is application of an inverse technique (such as dipole modelling or sLORETA) on the component extracted by independent component analysis (ICA) (sensor-space ICA + inverse technique). The advantage of this approach over an inverse technique alone is that it can identify and localize multiple concurrent sources. Among inverse techniques, the minimum-variance beamformers offer a high spatial resolution. However, in order to have both high spatial resolution of beamformer and be able to take on multiple concurrent sources, sensor-space ICA + beamformer is not an ideal combination. We propose source-space ICA for MEG as a powerful alternative approach which can provide the high spatial resolution of the beamformer and handle multiple concurrent sources. The concept of source-space ICA for MEG is to apply the beamformer first and then singular value decomposition + ICA. In this paper we have compared source-space ICA with sensor-space ICA both in simulation and real MEG. The simulations included two challenging scenarios of correlated/concurrent cluster sources. Source-space ICA provided superior performance in spatial reconstruction of source maps, even though both techniques performed equally from a temporal perspective. Real MEG from two healthy subjects with visual stimuli were also used to compare performance of sensor-space ICA and source-space ICA. We have also proposed a new variant of minimum-variance beamformer called weight-normalized linearly-constrained minimum-variance with orthonormal lead-field. As sensor-space ICA-based source reconstruction is popular in EEG and MEG imaging, and given that source-space ICA has superior spatial performance, it is expected that source-space ICA will supersede its predecessor in many applications.

  11. Synchrotron radiation imaging is a powerful tool to image brain microvasculature

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Mengqi; Sun, Danni; Xie, Yuanyuan; Xia, Jian; Long, Hongyu; Hu, Kai; Xiao, Bo, E-mail: [Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China); Peng, Guanyun [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)


    Synchrotron radiation (SR) imaging is a powerful experimental tool for micrometer-scale imaging of microcirculation in vivo. This review discusses recent methodological advances and findings from morphological investigations of cerebral vascular networks during several neurovascular pathologies. In particular, it describes recent developments in SR microangiography for real-time assessment of the brain microvasculature under various pathological conditions in small animal models. It also covers studies that employed SR-based phase-contrast imaging to acquire 3D brain images and provide detailed maps of brain vasculature. In addition, a brief introduction of SR technology and current limitations of SR sources are described in this review. In the near future, SR imaging could transform into a common and informative imaging modality to resolve subtle details of cerebrovascular function.

  12. Automated image analysis for space debris identification and astrometric measurements (United States)

    Piattoni, Jacopo; Ceruti, Alessandro; Piergentili, Fabrizio


    The space debris is a challenging problem for the human activity in the space. Observation campaigns are conducted around the globe to detect and track uncontrolled space objects. One of the main problems in optical observation is obtaining useful information about the debris dynamical state by the images collected. For orbit determination, the most relevant information embedded in optical observation is the precise angular position, which can be evaluated by astrometry procedures, comparing the stars inside the image with star catalogs. This is typically a time consuming process, if done by a human operator, which makes this task impractical when dealing with large amounts of data, in the order of thousands images per night, generated by routinely conducted observations. An automated procedure is investigated in this paper that is capable to recognize the debris track inside a picture, calculate the celestial coordinates of the image's center and use these information to compute the debris angular position in the sky. This procedure has been implemented in a software code, that does not require human interaction and works without any supplemental information besides the image itself, detecting space objects and solving for their angular position without a priori information. The algorithm for object detection was developed inside the research team. For the star field computation, the software code was used and released under GPL v2 license. The complete procedure was validated by an extensive testing, using the images obtained in the observation campaign performed in a joint project between the Italian Space Agency (ASI) and the University of Bologna at the Broglio Space center, Kenya.

  13. High Resolution, Radiation Tolerant Focal Plane Array for Lunar And Deep Space Applications Project (United States)

    National Aeronautics and Space Administration — Aerius Photonics and its partners propose the development of a high resolution, radiation hardened 3-D FLASH Focal Plane Array (FPA), with performance expected to be...

  14. Multifunctional Carbon Nanotube/Polyethylene Complex Composites for Space Radiation Shielding Project (United States)

    National Aeronautics and Space Administration — Polyethylene (PE), due to its high hydrogen content relative to its weight, has been identified by NASA as a promising radiation shielding material against galactic...

  15. Innovative, Lightweight Thoraeus RubberTM for MMOD and Space Radiation Shielding Project (United States)

    National Aeronautics and Space Administration — NanoSonic offers an innovative manufacturing process to yield ultra-lightweight radiation shielding nanocomposites by exploiting the concept of the Thoraeus filter...

  16. A Monte Carlo transport code study of the space radiation environment using FLUKA and ROOT

    CERN Document Server

    Wilson, T; Carminati, F; Brun, R; Ferrari, A; Sala, P; Empl, A; MacGibbon, J


    We report on the progress of a current study aimed at developing a state-of-the-art Monte-Carlo computer simulation of the space radiation environment using advanced computer software techniques recently available at CERN, the European Laboratory for Particle Physics in Geneva, Switzerland. By taking the next-generation computer software appearing at CERN and adapting it to known problems in the implementation of space exploration strategies, this research is identifying changes necessary to bring these two advanced technologies together. The radiation transport tool being developed is tailored to the problem of taking measured space radiation fluxes impinging on the geometry of any particular spacecraft or planetary habitat and simulating the evolution of that flux through an accurate model of the spacecraft material. The simulation uses the latest known results in low-energy and high-energy physics. The output is a prediction of the detailed nature of the radiation environment experienced in space as well a...

  17. Image-guided radiation therapy. Paradigm change in radiation therapy; Bildgestuetzte Strahlentherapie. Paradigmenwechsel in der Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Wenz, F. [Universitaetsmedizin Mannheim der Universitaet Heidelberg, Klinik fuer Strahlentherapie und Radioonkologie, Mannheim (Germany); Belka, C. [Klinikum der Ludwig-Maximilians-Universitaet, Klinik fuer Strahlentherapie und Radioonkologie, Muenchen (Germany); Reiser, M. [Klinikum der Ludwig-Maximilians-Universitaet, Institut fuer Klinische Radiologie, Muenchen (Germany); Schoenberg, S.O. [Universitaetsmedizin Mannheim der Universitaet Heidelberg, Institut fuer Klinische Radiologie und Nuklearmedizin, Mannheim (Germany)


    The introduction of image-guided radiotherapy (IGRT) has changed the workflow in radiation oncology more dramatically than any other innovation in the last decades. Imaging for treatment planning before the initiation of the radiotherapy series does not take alterations in patient anatomy and organ movement into account. The principle of IGRT is the temporal and spatial connection of imaging in the treatment position immediately before radiation treatment. The actual position and the target position are compared using cone-beam computed tomography (CT) or stereotactic ultrasound. The IGRT procedure allows a reduction of the safety margins and dose to normal tissue without an increase in risk of local recurrence. In the future the linear treatment chain in radiation oncology will be developed based on the closed-loop feedback principle. The IGRT procedure is increasingly being used especially for high precision radiotherapy, e.g. for prostate or brain tumors. (orig.) [German] Die Einfuehrung der bildgestuetzten Radiotherapie (IGRT - ''image-guided radiotherapy'') hat wie kaum eine andere Innovation die Behandlungsablaeufe in der Radioonkologie veraendert. Eine einmalige Bildgebung zur Bestrahlungsplanung vor der Behandlungsserie beruecksichtigt nicht die Aenderung der Patientengeometrie und die Organbeweglichkeit. Das Prinzip der IGRT besteht in der raeumlichen und zeitlichen Zusammenfuehrung von Bildgebung in der Bestrahlungsposition unmittelbar vor der eigentlichen Bestrahlung. Mittels Cone-beam-CT oder stereotaktischem Ultraschall wird die Ist- mit der Sollposition verglichen. Die IGRT erlaubt die Reduktion der Sicherheitssaeume und damit die Schonung des Normalgewebes, ohne das Rezidivrisiko zu erhoehen. Zukuenftig wird die lineare Behandlungskette in der Radioonkologie durch eine geschlossene, multipel rueckgekoppelte Therapieschleife ersetzt werden. Speziell bei Praezisionsbestrahlungen wie z. B. Prostata- oder Hirntumoren kommt die IGRT

  18. Global Solar radiation in Spain from Satellite Images; Radiacion Solar Global en la Espana Peninsular a partir de images de satelite

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez Santigosa, L.; Mora Lopez, L.; Sidrach de Cardona Ortin, M.; Navarro Fernandez, A. A.; Varela conde, M.; Cruz Echeandia, M. de la


    In the context of the present work a series of algorithms of calculation of the solar radiation from satellite images has been developed. These models, have been applied to three years of images of the Meteosat satellite and the results of the treatment have been extrapolated to long term. For the development of the models of solar radiation registered in ground stations have been used, corresponding all of them to localities of peninsular Spain and the Balearic ones. The maximum periods of data available have been used, supposing in most of the cases periods of between 6 and 9 years. From the results has a year type of images of global solar radiation on horizontal surface. The original resolution of the image of 7x7 km in the study latitudes, has been revaluate to 5x5 km. This supposes to have a value of the typical radiation for every day of the year, each 5x5 km in the study territory. This information, supposes an important advance as far as the knowledge of the space distribution of the radiation solar,impossible to reach about alternative methods. Doubtlessly, the precision of the provided values is not comparable with pyranometric measures in a concrete localise, but it provides a very valid indicator in places in which, it not had previous information. In addition to the radiation maps, tables of the global solar radiation have been prepared on different inclinations, from the global radiation on horizontal surface calculated for every day of the year and in each pixel of the image. (Author) 24 refs.

  19. Emergency imaging assessment of deep neck space infections. (United States)

    Maroldi, Roberto; Farina, Davide; Ravanelli, Marco; Lombardi, Davide; Nicolai, Piero


    Deep neck space infection may lead to severe and potentially life-threatening complications, such as airway obstruction, mediastinitis, septic embolization, dural sinus thrombosis, and intracranial abscess. The clinical presentation is widely variable, and often early symptoms do not reflect the disease severity. The complication risk depends on the extent and anatomical site: diseases that transgress fascial boundaries and spread along vertically oriented spaces (parapharyngeal, retropharyngeal, and paravertebral space) have a higher risk of complications and require a more aggressive treatment compared with those confined within a nonvertically oriented space (peritonsillar, sublingual, submandibular, parotid, and masticator space). Imaging has 5 crucial roles: (1) confirm the suspected clinical diagnosis, (2) define the precise extent of the disease, (3) identify complications, (4) distinguish between drainable abscesses and cellulitis, and (5) monitor deep neck space infection progression. Ultrasonography is the gold standard to differentiate abscesses from cellulitis, for the diagnosis of lymphadenitis. and to identify internal jugular thrombophlebitis in the infrahyoid neck. However, field-of-view limitation and poor anatomical information confine the use of ultrasonography to the evaluation of superficial lesions and to image-guided aspiration or drainage. Computed tomography (CT) combines fast image acquisition and precise anatomical information without field-of-view limitations. For these reasons, it is the most reliable technique for the evaluation of deep and multicompartment lesions and for the identification of mediastinal and intracranial complications. Contrast agent administration enhances the capability to differentiate fluid collections from cellulitis and allows the detection of vascular complications. Magnetic resonance imaging is more time-consuming than CT, limiting its use to selected indications. It is the technique of choice for assessing

  20. Images of deep neck space infection and the clinical significance. (United States)

    Wang, Bing; Gao, Bu-Lang; Xu, Guo-Ping; Xiang, Cheng


    Deep neck infection is not difficult to diagnose clinically, but correct localization of the involved space for timely incision and drainage is not easy without assistance of imaging. To investigate the images of deep neck space infection of phlegmon and abscess and the role of imaging examination in correct localization and treatment. Between June 2004 and June 2010, 28 patients were diagnosed with deep neck infection (14 men, 14 women; age range, 17-72 years; mean age, 46 years). Clinical presentations included neck swelling, pain, dysphagia, fever, and elevated white blood cell count. Of the 28 cases, 20 had computed tomography (CT) scans, 18 had magnetic resonance imaging (MRI) examinations, and 10 had both CT and MRI. All 28 patients were confirmed by CT and/or MRI to have deep neck infection, with 11 cases in the retropharyngeal space, five in the parapharyngeal space, four in the masseteric space, and eight in multiple spaces. Thirteen cases had abscesses that were successfully treated with incision and drainage under CT guidance in combination with large doses of antibiotics, and 15 had phlegmon managed with large doses of antibiotics. Followed up for 5-20 months, all patients recovered completely. Two patients were confirmed by imaging examination to have retropharyngeal infection spreading to the superior mediastinum with abscess formation and another two patients had multiple space infection because inappropriate puncture or incision for drainage without imaging guidance in these patients caused the spread of infection. Clinical diagnosis was not accurate with only 12 patients (42.9%) being correctly diagnosed of the exact deep neck space involved before imaging confirmation. CT and/or MRI made the correct diagnosis in all 28 patients. CT and/or MRI also directly changed the treatment plan in seven patients and contributed to the recovery of these patients. CT and MRI play a crucial role in both the diagnosis and correct puncture and incision for

  1. Estimation of Radiation Limit from a Huygens' Box under Non-Free-Space Conditions

    DEFF Research Database (Denmark)

    Franek, Ondrej; Sørensen, Morten; Bonev, Ivan Bonev


    The recently studied Huygens' box method has difficulties when radiation of an electronic module is to be determined under non-free-space conditions, i.e. with an enclosure. We propose an estimate on radiation limit under such conditions based only on the Huygens' box data from free...

  2. Transient dynamics of secondary radiation from an HF pumped magnetized space plasma

    NARCIS (Netherlands)

    Norin, L.; Grach, S. M.; Thide, B.; Sergeev, E. N.; Leyser, T. B.


    In order to systematically analyze the transient wave and radiation processes that are excited when a high-frequency (HF) radio wave is injected into a magnetized space plasma, we have measured the secondary radiation, or stimulated electromagnetic emission ( SEE), from the ionosphere,

  3. Review of NASA approach to space radiation risk assessments for Mars exploration. (United States)

    Cucinotta, Francis A


    Long duration space missions present unique radiation protection challenges due to the complexity of the space radiation environment, which includes high charge and energy particles and other highly ionizing radiation such as neutrons. Based on a recommendation by the National Council on Radiation Protection and Measurements, a 3% lifetime risk of exposure-induced death for cancer has been used as a basis for risk limitation by the National Aeronautics and Space Administration (NASA) for low-Earth orbit missions. NASA has developed a risk-based approach to radiation exposure limits that accounts for individual factors (age, gender, and smoking history) and assesses the uncertainties in risk estimates. New radiation quality factors with associated probability distribution functions to represent the quality factor's uncertainty have been developed based on track structure models and recent radiobiology data for high charge and energy particles. The current radiation dose limits are reviewed for spaceflight and the various qualitative and quantitative uncertainties that impact the risk of exposure-induced death estimates using the NASA Space Cancer Risk (NSCR) model. NSCR estimates of the number of "safe days" in deep space to be within exposure limits and risk estimates for a Mars exploration mission are described.


    Directory of Open Access Journals (Sweden)

    A. I. Altukhov


    Full Text Available Subject of Research. The paper deals withan approach to the image quality improvement of the underlying surface, obtained by space-based facilities in the visible spectrum. The approach is based on the idea of the region image synthesis with different exposures. This enables to increase the dynamic range of image brightness and display bright and poorly lighted places on the result picture. The relevance of the proposed approach is confirmed by simulation results of objects image quality under a variety of lighting conditions. Linear ground resolution is selected as the quality indicator. Main Results. We have carried out behavior analysis of possible changes in the lighting conditions of the underlying surface in the range of onboard equipment swath of spacecraft observation.We have performed calculation of the terrain linear resolution in narrow spectral ranges of visible light for the space image fragments of the underlying surface with different illumination. It was concluded that the quality of satellite images is limited, since the parameters of onboard equipment monitoring are not selected individually for each object detected within the swath. We have proposed an approach to improve the image quality. Practical Relevance. The proposed approach to the processing of the Earth remote sensing data gives the possibility to obtain images suitable for interpretation with account for specific features of illumination area, as well as to improve the dataware accuracy during the survey support and mapping of areas.

  5. Mitigation Strategies for Acute Radiation Exposure during Space Flight (United States)

    Hamilton, Douglas R.; Epelman, Slava


    While there are many potential risks in a Moon or Mars mission, one of the most important and unpredictable is that of crew radiation exposure. The two forms of radiation that impact a mission far from the protective environment of low-earth orbit, are solar particle events (SPE) and galactic cosmic radiation (GCR). The effects of GCR occur as a long-term cumulative dose that results increased longer-term medical risks such as malignancy and neurological degeneration. Unfortunately, relatively little has been published on the medical management of an acute SPE that could potentially endanger the mission and harm the crew. Reanalysis of the largest SPE in August 1972 revealed that the dose rate was significantly higher than previously stated in the literature. The peak dose rate was 9 cGy h(sup -1) which exceeds the low dose-rate criteria for 25 hrs (National Council on Radiation Protection) and 16 hrs (United Nations Scientific Committee on the Effects of Atomic Radiation). The bone marrow dose accumulated was 0.8 Gy, which exceeded the 25 and 16 hour criteria and would pose a serious medical risk. Current spacesuits would not provide shielding from the damaging effects for an SPE as large as the 1972 event, as increased shielding from 1-5 grams per square centimeters would do little to shield the bone marrow from exposure. Medical management options for an acute radiation event are discussed based on recommendations from the Department of Homeland Security, Centers for Disease Control and evidence-based scientific literature. The discussion will also consider how to define acute exposure radiation safety limits with respect to exploration-class missions, and to determine the level of care necessary for a crew that may be exposed to an SPE similar to August 1972.

  6. Cone beam computed tomography radiation dose and image quality assessments. (United States)

    Lofthag-Hansen, Sara


    Diagnostic radiology has undergone profound changes in the last 30 years. New technologies are available to the dental field, cone beam computed tomography (CBCT) as one of the most important. CBCT is a catch-all term for a technology comprising a variety of machines differing in many respects: patient positioning, volume size (FOV), radiation quality, image capturing and reconstruction, image resolution and radiation dose. When new technology is introduced one must make sure that diagnostic accuracy is better or at least as good as the one it can be expected to replace. The CBCT brand tested was two versions of Accuitomo (Morita, Japan): 3D Accuitomo with an image intensifier as detector, FOV 3 cm x 4 cm and 3D Accuitomo FPD with a flat panel detector, FOVs 4 cm x 4 cm and 6 cm x 6 cm. The 3D Accuitomo was compared with intra-oral radiography for endodontic diagnosis in 35 patients with 46 teeth analyzed, of which 41 were endodontically treated. Three observers assessed the images by consensus. The result showed that CBCT imaging was superior with a higher number of teeth diagnosed with periapical lesions (42 vs 32 teeth). When evaluating 3D Accuitomo examinations in the posterior mandible in 30 patients, visibility of marginal bone crest and mandibular canal, important anatomic structures for implant planning, was high with good observer agreement among seven observers. Radiographic techniques have to be evaluated concerning radiation dose, which requires well-defined and easy-to-use methods. Two methods: CT dose index (CTDI), prevailing method for CT units, and dose-area product (DAP) were evaluated for calculating effective dose (E) for both units. An asymmetric dose distribution was revealed when a clinical situation was simulated. Hence, the CTDI method was not applicable for these units with small FOVs. Based on DAP values from 90 patient examinations effective dose was estimated for three diagnostic tasks: implant planning in posterior mandible and

  7. Limitations on space flight due to cosmic radiations. (United States)



    These conclusions (10) may be summarized as follows: 1) Flight below the Van Allen belts seems reasonably safe without radiation shielding. 2) It is probably impractical to shield a rocket sufficiently to permit a man to remain in the inner Van Allen belt for more than about an hour, but it should be possible for him to go through it without serious harm. 3) Shielding for the outer Van Allen belt is possible but would have to be quite heavy if a stay of more than a few hours were contemplated. 4) The primary cosmic radiation is not intense enough to deliver a serious radiation dose, even for exposures of a few weeks, and the heavy cosmic ray primaries do not seem to present an unusual hazard.

  8. Radiation dose reduction and new image modalities development for interventional C-arm imaging system (United States)

    Niu, Kai

    Cardiovascular disease and stroke are the leading health problems and causes of death in the US. Due to the minimally invasive nature of the evolution of image guided techniques, interventional radiological procedures are becoming more common and are preferred in treating many cardiovascular diseases and strokes. In addition, with the recent advances in hardware and device technology, the speed and efficacy of interventional treatment has significantly improved. This implies that more image modalities can be developed based on the current C-arm system and patients treated in interventional suites can potentially experience better health outcomes. However, during the treatment patients are irradiated with substantial amounts of ionizing radiation with a high dose rate (digital subtraction angiography (DSA) with 3muGy/frame and 3D cone beam CT image with 0.36muGy/frame for a Siemens Artis Zee biplane system) and/or a long irradiation time (a roadmapping image sequence can be as long as one hour during aneurysm embolization). As a result, the patient entrance dose is extremely high. Despite the fact that the radiation dose is already substantial, image quality is not always satisfactory. By default a temporal average is used in roadmapping images to overcome poor image quality, but this technique can result in motion blurred images. Therefore, reducing radiation dose while maintaining or even improving the image quality is an important area for continued research. This thesis is focused on improving the clinical applications of C-arm cone beam CT systems in two ways: (1) Improve the performance of current image modalities on the C-arm system. (2) Develop new image modalities based on the current system. To be more specific, the objectives are to reduce radiation dose for current modalities (e.g., DSA, fluoroscopy, roadmapping, and cone beam CT) and enable cone beam CT perfusion and time resolved cone beam CT angiography that can be used to diagnose and triage acute

  9. Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. (United States)

    Casero, David; Gill, Kirandeep; Sridharan, Vijayalakshmi; Koturbash, Igor; Nelson, Gregory; Hauer-Jensen, Martin; Boerma, Marjan; Braun, Jonathan; Cheema, Amrita K


    Space travel is associated with continuous low dose rate exposure to high linear energy transfer (LET) radiation. Pathophysiological manifestations after low dose radiation exposure are strongly influenced by non-cytocidal radiation effects, including changes in the microbiome and host gene expression. Although the importance of the gut microbiome in the maintenance of human health is well established, little is known about the role of radiation in altering the microbiome during deep-space travel. Using a mouse model for exposure to high LET radiation, we observed substantial changes in the composition and functional potential of the gut microbiome. These were accompanied by changes in the abundance of multiple metabolites, which were related to the enzymatic activity of the predicted metagenome by means of metabolic network modeling. There was a complex dynamic in microbial and metabolic composition at different radiation doses, suggestive of transient, dose-dependent interactions between microbial ecology and signals from the host's cellular damage repair processes. The observed radiation-induced changes in microbiota diversity and composition were analyzed at the functional level. A constitutive change in activity was found for several pathways dominated by microbiome-specific enzymatic reactions like carbohydrate digestion and absorption and lipopolysaccharide biosynthesis, while the activity in other radiation-responsive pathways like phosphatidylinositol signaling could be linked to dose-dependent changes in the abundance of specific taxa. The implication of microbiome-mediated pathophysiology after low dose ionizing radiation may be an unappreciated biologic hazard of space travel and deserves experimental validation. This study provides a conceptual and analytical basis of further investigations to increase our understanding of the chronic effects of space radiation on human health, and points to potential new targets for intervention in adverse radiation

  10. Block-Based Compressed Sensing for Neutron Radiation Image Using WDFB

    Directory of Open Access Journals (Sweden)

    Wei Jin


    Full Text Available An ideal compression method for neutron radiation image should have high compression ratio while keeping more details of the original image. Compressed sensing (CS, which can break through the restrictions of sampling theorem, is likely to offer an efficient compression scheme for the neutron radiation image. Combining wavelet transform with directional filter banks, a novel nonredundant multiscale geometry analysis transform named Wavelet Directional Filter Banks (WDFB is constructed and applied to represent neutron radiation image sparsely. Then, the block-based CS technique is introduced and a high performance CS scheme for neutron radiation image is proposed. By performing two-step iterative shrinkage algorithm the problem of L1 norm minimization is solved to reconstruct neutron radiation image from random measurements. The experiment results demonstrate that the scheme not only improves the quality of reconstructed image obviously but also retains more details of original image.

  11. From 'Image Gently' to image intelligently: a personalized perspective on diagnostic radiation risk. (United States)

    Guillerman, R Paul


    The risk of ionizing radiation from diagnostic imaging has been a popular topic in the radiology literature and lay press. Communicating the magnitude of risk to patients and caregivers is problematic because of the uncertainty in estimates derived principally from epidemiological studies of large populations, and alternative approaches are needed to provide a scientific basis for personalized risk estimates. The underlying patient disease and life expectancy greatly influence risk projections. Research into the biological mechanisms of radiation-induced DNA damage and repair challenges the linear no-threshold dose-response assumption and reveals that individuals vary in sensitivity to radiation. Studies of decision-making psychology show that individuals are highly susceptible to irrational biases when judging risks. Truly informed medical decision-making that respects patient autonomy requires appropriate framing of radiation risks in perspective with other risks and with the benefits of imaging. To follow the principles of personalized medicine and treat patients according to their specific phenotypic and personality profiles, diagnostic imaging should optimally be tailored not only to patient size, body region and clinical indication, but also to underlying disease conditions, radio-sensitivity and risk perception and preferences that vary among individuals.

  12. Laser system for testing radiation imaging detector circuits (United States)

    Zubrzycka, Weronika; Kasinski, Krzysztof


    Performance and functionality of radiation imaging detector circuits in charge and position measurement systems need to meet tight requirements. It is therefore necessary to thoroughly test sensors as well as read-out electronics. The major disadvantages of using radioactive sources or particle beams for testing are high financial expenses and limited accessibility. As an alternative short pulses of well-focused laser beam are often used for preliminary tests. There are number of laser-based devices available on the market, but very often their applicability in this field is limited. This paper describes concept, design and validation of laser system for testing silicon sensor based radiation imaging detector circuits. The emphasis is put on keeping overall costs low while achieving all required goals: mobility, flexible parameters, remote control and possibility of carrying out automated tests. The main part of the developed device is an optical pick-up unit (OPU) used in optical disc drives. The hardware includes FPGA-controlled circuits for laser positioning in 2 dimensions (horizontal and vertical), precision timing (frequency and number) and amplitude (diode current) of short ns-scale (3.2 ns) light pulses. The system is controlled via USB interface by a dedicated LabVIEW-based application enabling full manual or semi-automated test procedures.

  13. The share flight experiment - An advanced heat pipe radiator for Space Station (United States)

    Alario, J. P.; Otterstedt, P. J.


    This paper reports on the design and thermal vacuum certification testing of the Space Station Heat Pipe Advanced Radiator Element (SHARE) Shuttle flight experiment, with primary emphasis on the heat pipe radiator system. The main objective of the SHARE experiment is to demonstrate suitable 0 g heat transfer performance of a 50 ft-long high-capacity monogroove heat pipe radiator element being developed for possible Space Station application. All of the flight certification tests were achieved, including a maximum heat rejection of 2 kW and thawing of a frozen heat pipe; and uninterrupted operation under cycling environmental and evaporator heat loads.

  14. Space Station Radiator Test Hosted by NASA Lewis at Plum Brook Station (United States)

    Speth, Randall C.


    In April of 1997, the NASA Lewis Research Center hosted the testing of the photovoltaic thermal radiator that is to be launched in 1999 as part of flight 4A of the International Space Station. The tests were conducted by Lockheed Martin Vought Systems of Dallas, who built the radiator. This radiator, and three more like it, will be used to cool the electronic system and power storage batteries for the space station's solar power system. Three of the four units will also be used early on to cool the service module.

  15. Space Group Debris Imaging Based on Sparse Sample

    Directory of Open Access Journals (Sweden)

    Zhu Jiang


    Full Text Available Space group debris imaging is difficult with sparse data in low Pulse Repetition Frequency (PRF spaceborne radar. To solve this problem in the narrow band system, we propose a method for space group debris imaging based on sparse samples. Due to the diversity of mass, density, and other factors, space group debris typically rotates at a high speed in different ways. We can obtain angular velocity through the autocorrelation function based on the diversity in the angular velocity. The scattering field usually presents strong sparsity, so we can utilize the corresponding measurement matrix to extract the data of different debris and then combine it using the sparse method to reconstruct the image. Furthermore, we can solve the Doppler ambiguity with the measurement matrix in low PRF systems and suppress some energy of other debris. Theoretical analysis confirms the validity of this methodology. Our simulation results demonstrate that the proposed method can achieve high-resolution Inverse Synthetic Aperture Radar (ISAR images of space group debris in low PRF systems.

  16. Color image segmentation using perceptual spaces through applets ...

    African Journals Online (AJOL)

    Color image segmentation using perceptual spaces through applets for determining and preventing diseases in chili peppers. JL González-Pérez, MC Espino-Gudiño, J Gudiño-Bazaldúa, JL Rojas-Rentería, V Rodríguez-Hernández, VM Castaño ...


    Directory of Open Access Journals (Sweden)

    Carmen Arena


    Full Text Available The growth of plants in Space is a fundamental issue for Space exploration. Plants play an important role in the Bioregenerative Life Support Systems (BLSS to sustain human permanence in extraterrestrial environments. Under this perspective, plants are basic elements for oxygen and fresh food production as well as air regeneration and psychological support to the crew. The potentiality of plant survival and reproduction in space is limited by the same factors that act on the earth (e.g. light, temperature and relative humidity and by additional factors such as altered gravity and ionizing radiation. This paper analyzes plant responses to space radiation which is recognized as a powerful mutagen for photosynthetic organisms thus being responsible for morpho-structural, physiological and genetic alterations. Until now, many studies have evidenced how the response to ionizing radiation is influenced by several factors associated both to plant characteristics (e.g. cultivar, species, developmental stage, tissue structure and/or radiation features (e.g. dose, quality and exposure time. The photosynthetic machinery is particularly sensitive to ionizing radiation. The severity of the damages induced by ionizing radiation on plant cell and tissues may depend on the capability of plants to adopt protection mechanisms and/or repair strategies. In this paper a selection of results from studies on the effect of ionizing radiations on plants at anatomical and eco-physiological level is reported and some aspects related to radioresistance are explored.

  18. Space Radar Image of Craters of the Moon, Idaho (United States)


    Ancient lava flows dating back 2,000 to 15,000 years are shown in light green and red on the left side of this space radar image of the Craters of the Moon National Monument area in Idaho. The volcanic cones that produced these lava flows are the dark points shown within the light green area. Craters of the Moon National Monument is part of the Snake River Plain volcanic province. Geologists believe this area was formed as the North American tectonic plate moved across a 'hot spot' which now lies beneath Yellowstone National Park. The irregular patches, shown in red, green and purple in the lower half of the image are lava flows of different ages and surface roughnesses. One of these lava flows is surrounded by agricultural fields, the blue and purple geometric features, in the right center of the image. The town of Arco, Idaho is the bright yellow area on the right side of the agricultural area. The peaks along the top of the image are the White Knob Mountains. The Big Lost River flows out of the canyon at the top right of the image. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) when it flew aboard the space shuttle Endeavour on October 5, 1994. This image is centered at 43.58 degrees north latitude, 113.42 degrees west longitude. The area shown is approximately 33 kilometers by 48 kilometers 20.5 miles by 30 miles). Colors are assigned to different frequencies and polarizations of the radar as follows: red is the L-band horizontally transmitted, horizontally received; green is the L-band horizontally transmitted, vertically received; blue is the C-band horizontally transmitted, vertically received. SIR-C/X-SAR, a joint mission of the German, Italian and United States space agencies, is part of NASA's Mission to Planet Earth program.

  19. Preparing the way to space borne Fresnel imagers. Space scenarios optical layouts (United States)

    Deba, Paul; Etcheto, Pierre; Duchon, Paul


    The Fresnel Diffractive Array Imager (FDAI) relies on diffraction focusing to potentially ouput very high wavefront quality particularly in the Ultraviolet. After Chesnokov (Russ Space Bull 1(2), 1993) or Barton (Appl Opt 40(4):447-451, 2001), we intend to develop tangible optical designs for space missions at the horizon 2025. This paper refers to the phase 0 study completed at CNES. We canvass here different optical scenarios adapted to space formation flying, discussing the technologies involved, their level of maturity and criticity. Large spectral domains were investigated from Lyman- α to Infra-Red, with competitive aperture size and ambitious objectives. We conclude by a 4-m class UV space mission scenario that could be the first launched imager of this kind.

  20. Design considerations for space radiators based on the liquid sheet (LSR) concept (United States)

    Juhasz, Albert J.; Chubb, Donald L.


    Concept development work on space heat rejection subsystems tailored to the requirements of various space power conversion systems is proceeding over a broad front of technologies at NASA LeRC. Included are orbital and planetary surface based radiator concepts utilizing pumped loops, a variety of heat pipe radiator concepts, and the innovative liquid sheet radiator (LSR). The basic feasibility of the LSR concept was investigated in prior work which generated preliminary information indicating the suitability of the LSR concept for space power systems requiring cycle reject heat to be radiated to the space sink at low-to-mid temperatures (300 to 400 K), with silicon oils used for the radiator working fluid. This study is directed at performing a comparative examination of LSR characteristics as they affect the basic design of low earth orbit solar dynamic power conversion systems. The power systems considered were based on the closed Brayton (CBC) and the Free Piston Stirling (FPS) cycles, each with a power output of 2 kWe and using previously tested silicone oil (Dow-Corning Me2) as the radiator working fluid. Conclusions indicate that, due to its ability for direct cold end cooling, an LSR based heat rejection subsystem is far more compatible with a Stirling space power system than with a CBC, which requires LSR coupling by means of an intermediate gas/liquid heat exchanger and adjustment of cycle operating conditions.

  1. A novel DC Magnetron sputtering facility for space research and synchrotron radiation optics

    DEFF Research Database (Denmark)

    Hussain, A.M.; Christensen, Finn Erland; Pareschi, G.


    A new DC magnetron sputtering facility has been build up at the Danish Space Research Institute (DSRI), specially designed to enable uniform coatings of large area curved optics, such as Wolter-I mirror optics used in space telescopes and curved optics used in synchrotron radiation facilities...

  2. The Nasa space radiation school, an excellent training in radiobiology and space radiation protection; La NASA space radiation summer school, une formation d'excellence en radiobiologie et radioprotection spatiale

    Energy Technology Data Exchange (ETDEWEB)

    Vogin, G. [Centre Alexis-Vautrin, 54 - Nancy (France)


    The astronauts have to spend more time in space and the colonization of the moon and Mars are in the cross hairs of international agencies. The cosmic radiation from which we are protected on ground by atmosphere and by the terrestrial magnetosphere (.4 mSv/year according to Who) become really threatening since 20 km altitude, delivering an average radiation dose of a therapeutic kind to astronauts with peaks related to solar events. It is composed in majority of hadrons: protons (85%) and heavy ions (13%), but also photons (2%) of high energy (GeV/n)). the incurred risks are multiple: early ones(cataract, central nervous system damages, whole body irradiation) but especially delayed ones (carcinogenesis). The astronauts radiation protection turns poor and the rate of death risk by cancer returning from a mission on Mars has been estimated at 5%. The Nasa created in 2004 a summer school aiming to awareness young researchers to the space radiobiology specificities. Areas concerned as follow: radioinduced DNA damage and repair, cell cycle, apoptosis, bystander effect, genome instability, neuro degeneration, delayed effects and carcinogenesis in relation with radiation exposure. (N.C.)

  3. A Medipix-Based Small Personal Space Radiation Dosimeter Project (United States)

    National Aeronautics and Space Administration — This SBIR effort will take the first step in improving the existing Medipix dosimeter technology in terms of advancing the technique now used to couple the actual...

  4. Space Electronics Operating at High Temperatures and Radiation Levels Project (United States)

    National Aeronautics and Space Administration — The objective is to produce high efficiency DC/DC power modules in a small low profile package that can tolerate extreme environment conditions. The primary effort...

  5. Real Time Space Radiation Effects in Electronic Systems Project (United States)

    National Aeronautics and Space Administration — The ability to predict the occurrence and magnitude of solar particle events (coronal mass ejections and solar flares) has been elusive so exposure of astronauts and...

  6. Space Electronics Operating at High Temperatures and Radiation Levels Project (United States)

    National Aeronautics and Space Administration — The proposal represents a radical revolution in Power Management & Distribution (PMAD) that addresses many of the challenges for NASA missions that will operate...

  7. Radiation Resistant, Reconfigurable, Shape Memory Metal Rubber Space Arrays Project (United States)

    National Aeronautics and Space Administration — NanoSonic has demonstrated that Shape Memory Metal RubberTM (SM-MR) adaptive skins exhibit reconfigurable and durable RF properties. It is hypothesized that such...

  8. Radiation resistance of thin-film solar cells for space photovoltaic power (United States)

    Woodyard, James R.; Landis, Geoffrey A.


    Copper indium diselenide, cadmium telluride, and amorphous silicon alloy solar cells have achieved noteworthy performance and are currently being studied for space power applications. Cadmium sulfide cells had been the subject of much effort but are no longer considered for space applications. A review is presented of what is known about the radiation degradation of thin film solar cells in space. Experimental cadmium telluride and amorphous silicon alloy cells are reviewed. Damage mechanisms and radiation induced defect generation and passivation in the amorphous silicon alloy cell are discussed in detail due to the greater amount of experimental data available.

  9. Quality of Intensity Modulated Radiation Therapy Treatment Plans Using a (60)Co Magnetic Resonance Image Guidance Radiation Therapy System

    DEFF Research Database (Denmark)

    Wooten, H Omar; Green, Olga; Yang, Min


    PURPOSE: This work describes a commercial treatment planning system, its technical features, and its capabilities for creating (60)Co intensity modulated radiation therapy (IMRT) treatment plans for a magnetic resonance image guidance radiation therapy (MR-IGRT) system. METHODS AND MATERIALS...

  10. Experimental Studies of Carbon Nanotube Materials for Space Radiators (United States)

    SanSoucie, MIchael P.; Rogers, Jan R.; Craven, Paul D.; Hyers, Robert W.


    Game ]changing propulsion systems are often enabled by novel designs using advanced materials. Radiator performance dictates power output for nuclear electric propulsion (NEP) systems. Carbon nanotubes (CNT) and carbon fiber materials have the potential to offer significant improvements in thermal conductivity and mass properties. A test apparatus was developed to test advanced radiator designs. This test apparatus uses a resistance heater inside a graphite tube. Metallic tubes can be slipped over the graphite tube to simulate a heat pipe. Several sub ]scale test articles were fabricated using CNT cloth and pitch ]based carbon fibers, which were bonded to a metallic tube using an active braze material. The test articles were heated up to 600 C and an infrared (IR) camera captured the results. The test apparatus and experimental results are presented here.

  11. NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity. (United States)

    Chylack, Leo T; Peterson, Leif E; Feiveson, Alan H; Wear, Mary L; Manuel, F Keith; Tung, William H; Hardy, Dale S; Marak, Lisa J; Cucinotta, Francis A


    The NASA Study of Cataract in Astronauts (NASCA) is a 5-year longitudinal study of the effect of space radiation exposure on the severity/progression of nuclear, cortical and posterior subcapsular (PSC) lens opacities. Here we report on baseline data that will be used over the course of the longitudinal study. Participants include 171 consenting astronauts who flew at least one mission in space and a comparison group made up of three components: (a) 53 astronauts who had not flown in space, (b) 95 military aircrew personnel, and (c) 99 non-aircrew ground-based comparison subjects. Continuous measures of nuclear, cortical and PSC lens opacities were derived from Nidek EAS 1000 digitized images. Age, demographics, general health, nutritional intake and solar ocular exposure were measured at baseline. Astronauts who flew at least one mission were matched to comparison subjects using propensity scores based on demographic characteristics and medical history stratified by gender and smoking (ever/never). The cross-sectional data for matched subjects were analyzed by fitting customized non-normal regression models to examine the effect of space radiation on each measure of opacity. The variability and median of cortical cataracts were significantly higher for exposed astronauts than for nonexposed astronauts and comparison subjects with similar ages (P=0.015). Galactic cosmic space radiation (GCR) may be linked to increased PSC area (P=0.056) and the number of PSC centers (P=0.095). Within the astronaut group, PSC size was greater in subjects with higher space radiation doses (P=0.016). No association was found between space radiation and nuclear cataracts. Cross-sectional data analysis revealed a small deleterious effect of space radiation for cortical cataracts and possibly for PSC cataracts. These results suggest increased cataract risks at smaller radiation doses than have been reported previously.

  12. Simulation of DNA Damage in Human Cells from Space Radiation Using a Physical Model of Stochastic Particle Tracks and Chromosomes (United States)

    Ponomarev, Artem; Plante, Ianik; Hada, Megumi; George, Kerry; Wu, Honglu


    The formation of double-strand breaks (DSBs) and chromosomal aberrations (CAs) is of great importance in radiation research and, specifically, in space applications. We are presenting a recently developed model, in which chromosomes simulated by NASARTI (NASA Radiation Tracks Image) is combined with nanoscopic dose calculations performed with the Monte-Carlo simulation by RITRACKS (Relativistic Ion Tracks) in a voxelized space. The model produces the number of DSBs, as a function of dose for high-energy iron, oxygen, and carbon ions, and He ions. The combined model calculates yields of radiation-induced CAs and unrejoined chromosome breaks in normal and repair deficient cells. The merged computational model is calibrated using the relative frequencies and distributions of chromosomal aberrations reported in the literature. The model considers fractionated deposition of energy to approximate dose rates of the space flight environment. The merged model also predicts of the yields and sizes of translocations, dicentrics, rings, and more complex-type aberrations formed in the G0/G1 cell cycle phase during the first cell division after irradiation.

  13. Web-based description of the space radiation environment using the Bethe-Bloch model (United States)

    Cazzola, Emanuele; Calders, Stijn; Lapenta, Giovanni


    Space weather is a rapidly growing area of research not only in scientific and engineering applications but also in physics education and in the interest of the public. We focus especially on space radiation and its impact on space exploration. The topic is highly interdisciplinary, bringing together fundamental concepts of nuclear physics with aspects of radiation protection and space science. We give a new approach to presenting the topic by developing a web-based application that combines some of the fundamental concepts from these two fields into a single tool that can be used in the context of advanced secondary or undergraduate university education. We present DREADCode, an outreach or teaching tool to rapidly assess the current conditions of the radiation field in space. DREADCode uses the available data feeds from a number of ongoing space missions (ACE, GOES-13, GOES-15) to produce a first order approximation of the radiation dose an astronaut would receive during a mission of exploration in deep space (i.e. far from the Earth’s shielding magnetic field and from the radiation belts). DREADCode is based on an easy-to-use GUI interface available online from the European Space Weather Portal ( The core of the radiation transport computation to produce the radiation dose from the observed fluence of radiation observed by the spacecraft fleet considered is based on a relatively simple approximation: the Bethe-Bloch equation. DREADCode also assumes a simplified geometry and material configuration for the shields used to compute the dose. The approach is approximate and sacrifices some important physics on the altar of rapid execution time, which allows a real-time operation scenario. There is no intention here to produce an operational tool for use in space science and engineering. Rather, we present an educational tool at undergraduate level that uses modern web-based and programming methods to learn some of the most important

  14. Viewing Radiation Signatures of Solar Energetic Particles in Interplanetary Space (United States)


    2004). Recently, images of SW density streams have been obtained by heliospheric imagers on the STEREO spacecraft (Shee- ley et al., 2008...heliospheric mag- netic field is also beginning to be explored. Magnetic field characteristics of large flux-rope CMEs have been deter- mined from Faraday ...and slowly evolving SW magnetic fields is anticipated from Faraday -rotation observations with the Mileura Widefield Array (Salah et al., 2005

  15. Reducing human radiation risks on deep space missions (United States)


    and their family. Based on this, it can be argued that NASA is therefore correct in discriminating crew selection based on age/ gender and tiered...merit GCR Galactic Cosmic Radiation xviii GINA Genetic Information Non- Discrimination Act GLE ground level event GOES Global Online Enrollment...activities or EVAs). Table 2 shows the effective dose limits for workers of various ages, genders , and with comparison to either average 32

  16. Development of Countermeasure and Application technologies to Space Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ju Woon; Byun, Myung Woo; Kim, Jae Hun


    Basic studies to evaluate the microbial activity changes by irradiation, and identify the composting microorganisms using the hyperthermal composter were conducted. And establishment of research protocols on muscle atrophy mechanism using two-dimensional electrophoresis and various blotting analyses are conducted. And two bio-active molecules that potentially play an preventive role of muscle atrophy are uncovered. Integrative protocols linking between the effect of bio-active molecules and treadmill exercise for muscle atrophy inhibition are established. And, successful induction of hibernation-like animation (reduction in body temperature and heartbeat rate) were monitored after HIT injection to mice. The space Bibimbap was developed by a combination treatment of 0.4% baking powder, soaking for 45 min, cooking, freezing, and packaging. It could be consumed easily after rehydration for 10 with 70 .deg. C water, which can be supplied from the International Space Station. And Bulgogi steak developed by combination treatment of packaging, freezing, antioxidant, charcoal and irradiation is a ready-to-eat type and has long shelf-life at the room temperature. Four foods items (Kimchi, Ramen, Saengshik bar, Sujeonggwa) were certified for the use in space flight conditions of 30 days by IBMP to be supplied to the first Korean astronaut, So-Yeon Lee, who accomplished space missions (sensory comparison test) at the International Space Station in 2008. To participate in the nutritional and physiological evaluation of Korean space foods in the MARS-500 project and evaluation of growth change in radio-durable micro organisms and plant seeds by space flight using BION-M1 satellite, a series of meeting were held in Russia and Korea

  17. Radiation Heat Transfer Procedures for Space-Related Applications (United States)

    Chai, John C.


    Over the last contract year, a numerical procedure for combined conduction-radiation heat transfer using unstructured grids has been developed. As a result of this research, one paper has been published in the Numerical Heat Transfer Journal. One paper has been accepted for presentation at the International Center for Heat and Mass Transfer's International Symposium on Computational Heat Transfer to be held in Australia next year. A journal paper is under review by my NASA's contact. A conference paper for the ASME National Heat Transfer conference is under preparation. In summary, a total of four (4) papers (two journal and two conference) have been published, accepted or are under preparation. There are two (2) to three (3) more papers to be written for the project. In addition to the above publications, one book chapter, one journal paper and six conference papers have been published as a result of this project. Over the last contract year, the research project resulted in one Ph.D. thesis and partially supported another Ph.D. student. My NASA contact and myself have formulated radiation heat transfer procedures for materials with different indices of refraction and for combined conduction-radiation heat transfer. We are trying to find other applications for the procedures developed under this grant.

  18. Optical synchrotron radiation beam imaging with a digital mask

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Hao [Univ. of Maryland, College Park, MD (United States); Fiorito, Ralph [Univ. of Maryland, College Park, MD (United States); Corbett, Jeff [SLAC National Accelerator Lab., Menlo Park, CA (United States); Shkvarunets, Anatoly [Univ. of Maryland, College Park, MD (United States); Tian, Kai [SLAC National Accelerator Lab., Menlo Park, CA (United States); Fisher, Alan [SLAC National Accelerator Lab., Menlo Park, CA (United States); Douglas, D. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Wilson, F. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Zhang, S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Mok, W. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Mitsuhashi, T. [KEK, Tsukuba (Japan)


    The 3GeV SPEAR3 synchrotron light source operates in top-up injection mode with up to 500mA circulating in the storage ring (equivalently 392nC). Each injection pulse contains only 40-80 pC producing a contrast ratio between total stored charge and injected charge of about 6500:1. In order to study transient injected beam dynamics during User operations, it is desirable to optically image the injected pulse in the presence of the bright stored beam. In the present work this is done by re-imaging visible synchrotron radiation onto a digital micro-mirror-array device (DMD), which is then used as an optical mask to block out light from the bright central core of the stored beam. The physical masking, together with an asynchronously-gated, ICCD imaging camera makes it is possible to observe the weak injected beam component on a turn-by-turn basis. The DMD optical masking system works similar to a classical solar coronagraph but has some distinct practical advantages: i.e. rapid adaption to changes in the shape of the stored beam, high extinction ratio for unwanted light and minimum scattering from the primary beam into the secondary optics. In this paper we describe the DMD masking method, features of the high dynamic range point spread function for the SPEAR3 optical beam line and measurements of the injected beam in the presence of the stored beam.

  19. Towards magnetic resonance imaging guided radiation therapy (MRIgRT) (United States)

    Stanescu, Teodor Marius

    The goal of this work is to address key aspects of the magnetic resonance imaging guided radiation therapy (MRIgRT) process of cancer sites. MRIgRT is implemented by using a system comprised of a magnetic resonance imaging (MRI) scanner coupled with a radiation source, in our case a radiotherapy accelerator (Linac). The potential benefits of MRIgRT are the real-time tracking of the tumor and neighbouring healthy anatomy during treatment irradiation leading to on-line treatment plan optimization. Ultimately, this results in an increased accuracy and efficiency of the overall treatment process. A large research effort is conducted at Cross Cancer Institute to develop a hybrid MRI-Linac system consisting of a bi-planar 0.2 T permanent magnet coupled with a 6 MV Linac. The present work is part of this project and aims to address the following key components: (a) magnetic shielding and dosimetric effects of the MRI-Linac system, (b) measure and correction of scanner-related MR image distortions, and (c) MRI-based treatment planning procedure for intracranial lesions. The first two components are essential for the optimal construction and operation of the MRI-Linac system while the third one represents a direct application of the system. The linac passive shielding was achieved by (a) adding two 10 cm thick steel (1020) plates placed at a distance of 10 cm from the structure on opposite sides of the magnet; and (b) a box lined with a 1 mm MuMetal(TM) wall surrounding the Linac. For our proposed MRI-Linac configuration (i.e. 0.2 T field and rotating bi-planar geometry) the maximum dose difference from zero magnetic field case was found to be within 6% and 12% in a water and water-lung-water phantom, respectively. We developed an image system distortion correction method for MRI that relies on adaptive thresholding and an iterative algorithm to determine the 3D distortion field. Applying this technique the residual image distortions were reduced to within the voxel

  20. Optical space weathering on Vesta: Radiative-transfer models and Dawn observations (United States)

    Blewett, David T.; Denevi, Brett W.; Le Corre, Lucille; Reddy, Vishnu; Schröder, Stefan E.; Pieters, Carle M.; Tosi, Federico; Zambon, Francesca; De Sanctis, Maria Cristina; Ammannito, Eleonora; Roatsch, Thomas; Raymond, Carol A.; Russell, Christopher T.


    Exposure to ion and micrometeoroid bombardment in the space environment causes physical and chemical changes in the surface of an airless planetary body. These changes, called space weathering, can strongly influence a surface's optical characteristics, and hence complicate interpretation of composition from reflectance spectroscopy. Prior work using data from the Dawn spacecraft (Pieters, C.M. et al. [2012]. Nature 491, 79-82) found that accumulation of nanophase metallic iron (npFe0), which is a key space-weathering product on the Moon, does not appear to be important on Vesta, and instead regolith evolution is dominated by mixing with carbonaceous chondrite (CC) material delivered by impacts. In order to gain further insight into the nature of space weathering on Vesta, we constructed model reflectance spectra using Hapke's radiative-transfer theory and used them as an aid to understanding multispectral observations obtained by Dawn's Framing Cameras (FC). The model spectra, for a howardite mineral assemblage, include both the effects of npFe0 and that of a mixed CC component. We found that a plot of the 438-nm/555-nm ratio vs. the 555-nm reflectance for the model spectra helps to separate the effects of lunar-style space weathering (LSSW) from those of CC-mixing. We then constructed ratio-reflectance pixel scatterplots using FC images for four areas of contrasting composition: a eucritic area at Vibidia crater, a diogenitic area near Antonia crater, olivine-bearing material within Bellicia crater, and a light mantle unit (referred to as an ;orange patch; in some previous studies, based on steep spectral slope in the visible) northeast of Oppia crater. In these four cases the observed spectral trends are those expected from CC-mixing, with no evidence for weathering dominated by production of npFe0. In order to survey a wider range of surfaces, we also defined a spectral parameter that is a function of the change in 438-nm/555-nm ratio and the 555-nm reflectance

  1. Marginal Space Deep Learning: Efficient Architecture for Volumetric Image Parsing. (United States)

    Ghesu, Florin C; Krubasik, Edward; Georgescu, Bogdan; Singh, Vivek; Yefeng Zheng; Hornegger, Joachim; Comaniciu, Dorin


    Robust and fast solutions for anatomical object detection and segmentation support the entire clinical workflow from diagnosis, patient stratification, therapy planning, intervention and follow-up. Current state-of-the-art techniques for parsing volumetric medical image data are typically based on machine learning methods that exploit large annotated image databases. Two main challenges need to be addressed, these are the efficiency in scanning high-dimensional parametric spaces and the need for representative image features which require significant efforts of manual engineering. We propose a pipeline for object detection and segmentation in the context of volumetric image parsing, solving a two-step learning problem: anatomical pose estimation and boundary delineation. For this task we introduce Marginal Space Deep Learning (MSDL), a novel framework exploiting both the strengths of efficient object parametrization in hierarchical marginal spaces and the automated feature design of Deep Learning (DL) network architectures. In the 3D context, the application of deep learning systems is limited by the very high complexity of the parametrization. More specifically 9 parameters are necessary to describe a restricted affine transformation in 3D, resulting in a prohibitive amount of billions of scanning hypotheses. The mechanism of marginal space learning provides excellent run-time performance by learning classifiers in clustered, high-probability regions in spaces of gradually increasing dimensionality. To further increase computational efficiency and robustness, in our system we learn sparse adaptive data sampling patterns that automatically capture the structure of the input. Given the object localization, we propose a DL-based active shape model to estimate the non-rigid object boundary. Experimental results are presented on the aortic valve in ultrasound using an extensive dataset of 2891 volumes from 869 patients, showing significant improvements of up to 45

  2. NASA Space Radiation Protection Strategies: Risk Assessment and Permissible Exposure Limits (United States)

    Huff, J. L.; Patel, Z. S.; Simonsen, L. C.


    Permissible exposure limits (PELs) for short-term and career astronaut exposures to space radiation have been set and approved by NASA with the goal of protecting astronauts against health risks associated with ionizing radiation exposure. Short term PELs are intended to prevent clinically significant deterministic health effects, including performance decrements, which could threaten astronaut health and jeopardize mission success. Career PELs are implemented to control late occurring health effects, including a 3% risk of exposure induced death (REID) from cancer, and dose limits are used to prevent cardiovascular and central nervous system diseases. For radiation protection, meeting the cancer PEL is currently the design driver for galactic cosmic ray and solar particle event shielding, mission duration, and crew certification (e.g., 1-year ISS missions). The risk of cancer development is the largest known long-term health consequence following radiation exposure, and current estimates for long-term health risks due to cardiovascular diseases are approximately 30% to 40% of the cancer risk for exposures above an estimated threshold (Deep Space one-year and Mars missions). Large uncertainties currently exist in estimating the health risks of space radiation exposure. Improved understanding through radiobiology and physics research allows increased accuracy in risk estimation and is essential for ensuring astronaut health as well as for controlling mission costs, optimization of mission operations, vehicle design, and countermeasure assessment. We will review the Space Radiation Program Element's research strategies to increase accuracy in risk models and to inform development and validation of the permissible exposure limits.

  3. Space Radiation Measurement on the Polar Route onboard the Korean Commercial Flights

    Directory of Open Access Journals (Sweden)

    Junga Hwang


    Full Text Available This study was performed by the policy research project of Ministry of Land, Transport and Maritime Affairs, which title is “Developing safety standards and management of space radiation on the polar route”. In this research, total six experiments were performed using Korean commercial flights (B747. Three of those are on the polar route and the other three are on the north pacific route. Space radiation exposure measured on the polar route is the average 84.7 uSv. The simulation result using CARI-6M program gives 84.9 uSv, which is very similar to measured value. For the departure flight using the north pacific route, the measured space radiation is the average 74.4 uSv. It seems that is not so different to use the polar route or not for the return flight because the higher latitude effect causing the increase of space radiation is compensated by the shortened flight time effect causing decreasing space radiation exposure.

  4. ENSO impact on surface radiative fluxes as observed from space (United States)

    Pinker, R. T.; Grodsky, S. A.; Zhang, B.; Busalacchi, A.; Chen, W.


    We investigate the impact of El Niño-Southern Oscillation (ENSO) on surface radiative fluxes over the tropical Pacific using satellite observations and fluxes derived from selected atmospheric reanalyses. Agreement between the two in this region is important because reanalysis information is frequently used to assess surface energy budget sensitivity to ENSO. We found that during the traditional ENSO, the maximum variance of anomalous incoming solar radiation is located just west of the dateline and coincides with the area of the largest anomalous SST gradient. It can reach up to 60 W/m2 and lags behind the Niño3 index by about a month, suggesting a response to anomalous SST gradient. The magnitude of longwave anomaly is only half that large and varies in phase with the SST anomaly. Similar anomalies were derived from outputs: from the European Centre for Medium-Weather Forecasts Reanalysis Interim (ERA-I), from the Modern Era Retrospective Analysis version 2 (MERRA-2), from the NCEP/NCAR Reanalysis 1 (R1), and from the Japanese JRA55 reanalysis. Among the four reanalyses used, results from ERA-I are the closest to observations. We have also investigated the surface wind divergence/convergence and found that the main factor limiting eastward excursions of convection is the surface wind convergence. Due to the wind divergence pattern normally present over the eastern cold tongue, anomalous convection extends into the eastern equatorial Pacific only during the strongest warm events. Our analysis also considers the El Niño Modoki events, for which the radiation flux patterns are shifted westward following the SST pattern.

  5. Space Radar Image of Central African Gorilla Habitat (United States)


    This is a false-color radar image of Central Africa, showing the Virunga Volcano chain along the borders of Rwanda, Zaire and Uganda. This area is home to the endangered mountain gorillas. This C-band L-band image was acquired on April 12, 1994, on orbit 58 of space shuttle Endeavour by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR). The area is centered at about 1.75 degrees south latitude and 29.5 degrees east longitude. The image covers an area 58 kilometers by 178 kilometers (48 miles by 178 miles). The false-color composite is created by displaying the L-band HH return in red, the L-band HV return in green and the C-band HH return in blue. The dark area in the bottom of the image is Lake Kivu, which forms the border between Zaire (to the left) and Rwanda (to the right). The airport at Goma, Zaire is shown as a dark line just above the lake in the bottom left corner of the image. Volcanic flows from the 1977 eruption of Mt. Nyiragongo are shown just north of the airport. Mt. Nyiragongo is not visible in this image because it is located just to the left of the image swath. Very fluid lava flows from the 1977 eruption killed 70 people. Mt. Nyiragongo is currently erupting (August 1994) and will be a target of observation during the second flight of SIR-C/X-SAR. The large volcano in the center of the image is Mt. Karisimbi (4,500 meters or 14,800 feet). This radar image highlights subtle differences in the vegetation and volcanic flows of the region. The faint lines shown in the purple regions are believed to be the result of agriculture terracing by the people who live in the region. The vegetation types are an important factor in the habitat of the endangered mountain gorillas. Researchers at Rutgers University in New Jersey and the Dian Fossey Gorilla Fund in London will use this data to produce vegetation maps of the area to aid in their study of the remaining 650 gorillas in the region. SIR-C was developed by NASA's Jet

  6. A Banach Space Regularization Approach for Multifrequency Microwave Imaging

    Directory of Open Access Journals (Sweden)

    Claudio Estatico


    Full Text Available A method for microwave imaging of dielectric targets is proposed. It is based on a tomographic approach in which the field scattered by an unknown target (and collected in a proper observation domain is inverted by using an inexact-Newton method developed in Lp Banach spaces. In particular, the extension of the approach to multifrequency data processing is reported. The mathematical formulation of the new method is described and the results of numerical simulations are reported and discussed, analyzing the behavior of the multifrequency processing technique combined with the Banach spaces reconstruction method.

  7. Space Radar Image of West Texas - SAR scan (United States)


    This radar image of the Midland/Odessa region of West Texas, demonstrates an experimental technique, called ScanSAR, that allows scientists to rapidly image large areas of the Earth's surface. The large image covers an area 245 kilometers by 225 kilometers (152 miles by 139 miles). It was obtained by the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) flying aboard the space shuttle Endeavour on October 5, 1994. The smaller inset image is a standard SIR-C image showing a portion of the same area, 100 kilometers by 57 kilometers (62 miles by 35 miles) and was taken during the first flight of SIR-C on April 14, 1994. The bright spots on the right side of the image are the cities of Odessa (left) and Midland (right), Texas. The Pecos River runs from the top center to the bottom center of the image. Along the left side of the image are, from top to bottom, parts of the Guadalupe, Davis and Santiago Mountains. North is toward the upper right. Unlike conventional radar imaging, in which a radar continuously illuminates a single ground swath as the space shuttle passes over the terrain, a Scansar radar illuminates several adjacent ground swaths almost simultaneously, by 'scanning' the radar beam across a large area in a rapid sequence. The adjacent swaths, typically about 50 km (31 miles) wide, are then merged during ground processing to produce a single large scene. Illumination for this L-band scene is from the top of the image. The beams were scanned from the top of the scene to the bottom, as the shuttle flew from left to right. This scene was acquired in about 30 seconds. A normal SIR-C image is acquired in about 13 seconds. The ScanSAR mode will likely be used on future radar sensors to construct regional and possibly global radar images and topographic maps. The ScanSAR processor is being designed for 1996 implementation at NASA's Alaska SAR Facility, located at the University of Alaska Fairbanks, and will produce digital images from the

  8. Predictions of integrated circuit serviceability in space radiation fields

    CERN Document Server

    Khamidullina, N M; Pichkhadze, K M; Popov, V D


    The present paper suggests an approach to estimating and predicting the serviceability of on-board electronic equipment. It is based on the postulates of the reliability theory and accounts for total-dose and single-event radiation effects as well as other exterior destabilizing factors. The methods of determination of failure and upset rates for CMOS devices are considered. The probability of non-failure operation of a two CMOS RAM is calculated along the whole trajectory of the 'Solar Probe' spacecraft.

  9. Exposure of space electronics and materials to ionizing radiation

    DEFF Research Database (Denmark)

    Korsbech, Uffe C C


    Describes the methods and sources available for irradiation of space instruments developed at the Department of Automation. Methods for calculations and measurements of fluences and doses are also described. The sources are gamma-rays from iridium-192 and cobalt-60, 30 MeV protons, 10 MeV electrons...

  10. Topology of digital images visual pattern discovery in proximity spaces

    CERN Document Server

    Peters, James F


    This book carries forward recent work on visual patterns and structures in digital images and introduces a near set-based a topology of digital images. Visual patterns arise naturally in digital images viewed as sets of non-abstract points endowed with some form of proximity (nearness) relation. Proximity relations make it possible to construct uniform topolo- gies on the sets of points that constitute a digital image. In keeping with an interest in gaining an understanding of digital images themselves as a rich source of patterns, this book introduces the basics of digital images from a computer vision perspective. In parallel with a computer vision perspective on digital images, this book also introduces the basics of prox- imity spaces. Not only the traditional view of spatial proximity relations but also the more recent descriptive proximity relations are considered. The beauty of the descriptive proximity approach is that it is possible to discover visual set patterns among sets that are non-overlapping ...

  11. Fast ultrasound imaging simulation in K-space. (United States)

    Hergum, Torbjørn; Langeland, Stian; Remme, Espen W; Torp, Hans


    Most available ultrasound imaging simulation methods are based on the spatial impulse response approach. The execution speed of such a simulation is of the order of days for one heart-sized frame using desktop computers. For some applications, the accuracy of such rigorous simulation approaches is not necessary. This work outlines a much faster 3-D ultrasound imaging simulation approach that can be applied to tasks like simulating 3-D ultrasound images for speckletracking. The increased speed of the proposed simulation method is based primarily on the approximation that the point spread function is set to be spatially invariant, which is a reasonably good approximation when using polar coordinates for simulating images from phased arrays with constant aperture. Ultrasound images are found as the convolution of the PSF and an object of sparsely distributed scatterers. The scatterers are passed through an anti-aliasing filter before insertion into a regular beam-space grid to reduce the bandwidth and significantly reduce the amount of data. A comparison with the well-established simulation software package Field II has been made. A simulation of a cyst image using the same input object was found to be in the order of 7000 times slower than the presented method. Following these considerations, the proposed simulation method can be a rapid and valuable tool for working with 3-D ultrasound imaging and in particular 3-D speckle-tracking.

  12. Application of a Near Infrared Imaging System for Thermographic Imaging of the Space Shuttle during Hypersonic Re-Entry (United States)

    Zalameda, Joseph N.; Tietjen, Alan B.; Horvath, Thomas J.; Tomek, Deborah M.; Gibson, David M.; Taylor, Jeff C.; Tack, Steve; Bush, Brett C.; Mercer, C. David; Shea, Edward J.


    observations confirmed the challenge of a long-range acquisition during re-entry. These challenges are due to unknown atmospheric conditions, image saturation, vibration etc. This provides the motivation for the use of a digital NIR sensor. The characterizations performed on the digital NIR sensor included radiometric, spatial, and spectral measurements using blackbody radiation sources and known targets. An assessment of the collected data for three Space Shuttle atmospheric re-entries, STS-119, STS-125, and STS-128, are provided along with a description of various events of interest captured using the digital NIR imaging system such as RCS firings and boundary layer transitions. Lastly the process used to convert the raw image counts to quantitative temperatures is presented along with comparisons to the Space Shuttle's onboard thermocouples.

  13. Preface: Solar energetic particles, solar modulation and space radiation: New opportunities in the AMS-02 Era (United States)

    Bindi, Veronica


    Solar Energetic Particle (SEP) acceleration at high energies and their propagation through the heliosphere and into the magnetosphere are not well understood and are still a matter of debate. Our understanding of solar modulation and transport of different species of galactic cosmic rays (GCR) inside the heliosphere has been significantly improved; however, a lot of work still needs to be done. GCR and SEPs pose a significant radiation risk for people and technology in space, and thus it is becoming increasingly important to understand the space radiation environment. AMS-02 will provide brand new information with unprecedented statistics about GCR and SEPs. Both GCR and heliophysics experiments will contribute to the increased understanding of acceleration physics, and transport of particles in space with improved models. This will inevitably lead to better predictions of space weather and safer operations in space.

  14. Simulated Space Radiation: Impact of Four Different Types of High-Dose Ionizing Radiation on the Lichen Xanthoria elegans (United States)

    Brandt, Annette; Meeßen, Joachim; Jänicke, Reiner U.; Raguse, Marina; Ott, Sieglinde


    This study addresses the viability of the lichen Xanthoria elegans after high-dose ionizing irradiation in the frame of the STARLIFE campaign. The first set of experiments was intended to resemble several types of galactic cosmic radiation (GCR) as present beyond the magnetic shield of Earth. In the second set of experiments, γ radiation up to 113 kGy was applied to test the limit of lichen resistance to ionizing radiation. Entire thalli of Xanthoria elegans were irradiated in the anhydrobiotic state. After STARLIFE 1, the metabolic activity of both symbionts was quantified by live/dead staining with confocal laser scanning microscopy. The photosynthetic activity was measured after the respective irradiation to assess the ability of the symbiotic green algae to restore photosynthesis after irradiation. The STARLIFE campaign complements the results of the LIFE experiments at the EXPOSE-E facility on the International Space Station by testing the model organism Xanthoria elegans on its resistance to hazardous radiation that might be accumulated during long-term space exposure. In addition, the photosynthetic activity of metabolically active lichen was investigated after X-ray irradiation up to 100 Gy (3.3 Gy/min). Since previous astrobiological experiments were mostly performed with anhydrobiotic lichen, these experiments will broaden our knowledge on the correlation of physiological state and astrobiological stressors.

  15. Space Radar Image of Manaus region of Brazil (United States)


    These L-band images of the Manaus region of Brazil were acquired by the Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour. The left image was acquired on April 12, 1994, and the middle image was acquired on October 3, 1994. The area shown is approximately 8 kilometers by 40 kilometers (5 miles by 25 miles). The two large rivers in this image, the Rio Negro (top) and the Rio Solimoes (bottom), combine at Manaus (west of the image) to form the Amazon River. The image is centered at about 3 degrees south latitude and 61 degrees west longitude. North is toward the top left of the images. The differences in brightness between the images reflect changes in the scattering of the radar channel. In this case, the changes are indicative of flooding. A flooded forest has a higher backscatter at L-band (horizontally transmitted and received) than an unflooded river. The extent of the flooding is much greater in the April image than in the October image, and corresponds to the annual, 10-meter (33-foot) rise and fall of the Amazon River. A third image at right shows the change in the April and October images and was created by determining which areas had significant decreases in the intensity of radar returns. These areas, which appear blue on the third image at right, show the dramatic decrease in the extent of flooded forest, as the level of the Amazon River falls. The flooded forest is a vital habitat for fish and floating meadows are an important source of atmospheric methane. This demonstrates the capability of SIR-C/X-SAR to study important environmental changes that are impossible to see with optical sensors over regions such as the Amazon, where frequent cloud cover and dense forest canopies obscure monitoring of floods. Field studies by boat, on foot and in low-flying aircraft by the University of California at Santa Barbara, in collaboration with Brazil's Instituto Nacional de Pesguisas Estaciais, during

  16. Space Radar Image Isla Isabela in 3-D (United States)


    This is a three-dimensional view of Isabela, one of the Galapagos Islands located off the western coast of Ecuador, South America. This view was constructed by overlaying a Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) image on a digital elevation map produced by TOPSAR, a prototype airborne interferometric radar which produces simultaneous image and elevation data. The vertical scale in this image is exaggerated by a factor of 1.87. The SIR-C/X-SAR image was taken on the 40th orbit of space shuttle Endeavour. The image is centered at about 0.5 degree south latitude and 91 degrees west longitude and covers an area of 75 by 60 kilometers (47 by 37 miles). The radar incidence angle at the center of the image is about 20 degrees. The western Galapagos Islands, which lie about 1,200 kilometers (750 miles)west of Ecuador in the eastern Pacific, have six active volcanoes similar to the volcanoes found in Hawaii and reflect the volcanic processes that occur where the ocean floor is created. Since the time of Charles Darwin's visit to the area in 1835, there have been more than 60 recorded eruptions on these volcanoes. This SIR-C/X-SAR image of Alcedo and Sierra Negra volcanoes shows the rougher lava flows as bright features, while ash deposits and smooth pahoehoe lava flows appear dark. Vertical exaggeration of relief is a common tool scientists use to detect relationships between structure (for example, faults, and fractures) and topography. Spaceborne Imaging Radar-C and X-Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data

  17. Space radar image of Ubar optical/radar (United States)


    This pair of images from space shows a portion of the southern Empty Quarter of the Arabian Peninsula in the country of Oman. On the left is a radar image of the region around the site of the fabled Lost City of Ubar, discovered in 1992 with the aid of remote sensing data. On the right is an enhanced optical image taken by the shuttle astronauts. Ubar existed from about 2800 BC to about 300 AD. and was a remote desert outpost where caravans were assembled for the transport of frankincense across the desert. The actual site of the fortress of the Lost City of Ubar, currently under excavation, is too small to show in either image. However, tracks leading to the site, and surrounding tracks, show as prominent, but diffuse, reddish streaks in the radar image. Although used in modern times, field investigations show many of these tracks were in use in ancient times as well. Mapping of these tracks on regional remote sensing images provided by the Landsat satellite was a key to recognizing the site as Ubar. The prominent magenta colored area is a region of large sand dunes. The green areas are limestone rocks, which form a rocky desert floor. A major wadi, or dry stream bed, runs across the scene and appears as a white line. The radar images, and ongoing field investigations, will help shed light on an early civilization about which little in known. The radar image was taken by the Spaceborne Imaging Radar C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) and is centered at 18 degrees North latitude and 53 degrees East longitude. The image covers an area about 50 kilometers by 100 kilometers (31 miles by 62 miles). The colors in the image are assigned to different frequencies and polarizations of the radar as follows: red is L-band, horizontally transmitted, horizontally received; blue is C-band horizontally transmitted, horizontally received; green is L-band horizontally transmitted, vertically received. SIR-C/X-SAR, a joint mission of the German, Italian and the United

  18. Radiation tests of the EMU spacesuit for the International Space Station using energetic protons


    Zeitlin, C.; Heilbronn, L.; Miller, J; Shavers, M.


    Measurements using silicon detectors to characterize the radiation transmitted through the EMU spacesuit and a human phantom have been performed using 155 and 250 MeV proton beams at the Loma Linda University Medical Center (LLUMC). The beams simulate radiation encountered in space, where trapped protons having kinetic energies on the order of 100 MeV are copious. Protons with 100 MeV kinetic energy and above can penetrate many centimeters of water of other light materials, so that astro...

  19. A Review of NASA's Radiation-Hardened Electronics for Space Environments Project (United States)

    Keys, Andrew S.; Adams, James H.; Patrick, Marshall C.; Johnson, Michael A.; Cressler, John D.


    NASA's Radiation Hardened Electronics for Space Exploration (RHESE) project develops the advanced technologies required to produce radiation hardened electronics, processors, and devices in support of the requirements of NASA's Constellation program. Over the past year, multiple advancements have been made within each of the RHESE technology development tasks that will facilitate the success of the Constellation program elements. This paper provides a brief review of these advancements, discusses their application to Constellation projects, and addresses the plans for the coming year.

  20. Early Breast Cancer Diagnosis Using Microwave Imaging via Space-Frequency Algorithm (United States)

    Vemulapalli, Spandana

    The conventional breast cancer detection methods have limitations ranging from ionizing radiations, low specificity to high cost. These limitations make way for a suitable alternative called Microwave Imaging, as a screening technique in the detection of breast cancer. The discernible differences between the benign, malignant and healthy breast tissues and the ability to overcome the harmful effects of ionizing radiations make microwave imaging, a feasible breast cancer detection technique. Earlier studies have shown the variation of electrical properties of healthy and malignant tissues as a function of frequency and hence stimulates high bandwidth requirement. A Ultrawideband, Wideband and Narrowband arrays have been designed, simulated and optimized for high (44%), medium (33%) and low (7%) bandwidths respectively, using the EM (electromagnetic software) called FEKO. These arrays are then used to illuminate the breast model (phantom) and the received backscattered signals are obtained in the near field for each case. The Microwave Imaging via Space-Time (MIST) beamforming algorithm in the frequency domain, is next applied to these near field backscattered monostatic frequency response signals for the image reconstruction of the breast model. The main purpose of this investigation is to access the impact of bandwidth and implement a novel imaging technique for use in the early detection of breast cancer. Earlier studies show the implementation of the MIST imaging algorithm on the time domain signals via a frequency domain beamformer. The performance evaluation of the imaging algorithm on the frequency response signals has been carried out in the frequency domain. The energy profile of the breast in the spatial domain is created via the frequency domain Parseval's theorem. The beamformer weights calculated using these the MIST algorithm (not including the effect of the skin) has been calculated for Ultrawideband, Wideband and Narrowband arrays, respectively

  1. High quantum efficiency megavoltage imaging with thick scintillator detectors for image guided radiation therapy (United States)

    Gopal, Arun

    In image guided radiation therapy (IGRT), imaging devices serve as guidance systems to aid patient set-up and tumor volume localization. Traditionally, 2-D megavoltage x-ray imagers, referred to as electronic portal imaging devices (EPIDs), have been used for planar target localization, and have recently been extended to perform 3-D volumetric reconstruction via cone-beam computed tomography (CBCT). However, current EPIDs utilize thin and inefficient phosphor screen detectors and are subsequently limited by poor soft tissue visualization, which limits their use for CBCT. Therefore, the use of thick scintillation media as megavoltage x-ray detectors for greater x-ray sensitivity and enhanced image quality has recently been of significant interest. In this research, two candidates for thick scintillators: CsI(Tl) and terbium doped scintillation glass were investigated in separate imaging configurations. In the first configuration, a thick scintillation crystal (TSC) consisting of a thick, monolithic slab of CsI(Tl) was coupled to a mirror-lens-camera system. The second configuration is based on a fiber-optic scintillation glass array (FOSGA), wherein the scintillation glass is drawn into long fiber-optic conduits, inserted into a grid-type housing constructed out of polymer-tungsten alloy, and coupled to an array of photodiodes for digital read-out. The imaging prototypes were characterized using theoretical studies and imaging measurements to obtain fundamental metrics of imaging performance. Spatial resolution was measured based on a modulation transfer function (MTF), noise was evaluated in terms of a noise power spectrum (NPS), and overall contrast was characterized in the form of detective quantum efficiency (DQE). The imaging studies were used to optimize the TSC and FOSGA imagers and propose prototype configurations for order-of-magnitude improvements in overall image quality. In addition, a fast and simple technique was developed to measure the MTF, NPS, and

  2. WE-A-BRF-01: Dual-Energy CT Imaging in Diagnostic Imaging and Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Molloi, S [University of California, Irvine, CA (United States); Li, B [Boston University Medical Center, Boston, MA (United States); Yin, F [Duke University Medical Center, Durham, NC (United States); Chen, H [New York Presbyterian Hospital, New York, NY (United States)


    classification based on calcium scores shows excellent agreement with classification on the basis of conventional coronary artery calcium scoring. These studies demonstrate dual-energy cardiovascular CT can potentially be a noninvasive and sensitive modality in high risk patients. On-board KV/MV Imaging. To enhance soft tissue contrast and reduce metal artifacts, we have developed a dual-energy CBCT technique and a novel on-board kV/MV imaging technique based on hardware available on modern linear accelerators. We have also evaluated the feasibility of these two techniques in various phantom studies. Optimal techniques (energy, beam filtration, # of overlapping projections, etc) have been investigated with unique calibration procedures, which leads to successful decomposition of imaged material into acrylic-aluminum basis material pair. This enables the synthesis of virtual monochromatic (VM) CBCT images that demonstrate much less beam hardening, significantly reduced metal artifacts, and/or higher soft tissue CNR compared to single-energy CBCT. Adaptive Radiation Therapy. DECT could actually contribute to the area of Dose-Guided Radiation Therapy (or Adaptive Therapy). The application of DECT imaging using 80kV and 140 kV combinations could potentially increase the image quality by reducing the bone or high density material artifacts and also increase the soft tissue contrast by a light contrast agent. The result of this higher contrast / quality images is beneficial for deformable image registration / segmentation algorithm to improve its accuracy hence to make adaptive therapy less time consuming in its recontouring process. The real time re-planning prior to per treatment fraction could become more realistic with this improvement especially in hypofractional SBRT cases. Learning Objectives: Learn recent developments of dual-energy imaging in diagnosis and radiation therapy; Understand the unique clinical problem and required quantification accuracy in each application

  3. An equivalent ground thermal test method for single-phase fluid loop space radiator

    Directory of Open Access Journals (Sweden)

    Xianwen Ning


    Full Text Available Thermal vacuum test is widely used for the ground validation of spacecraft thermal control system. However, the conduction and convection can be simulated in normal ground pressure environment completely. By the employment of pumped fluid loops’ thermal control technology on spacecraft, conduction and convection become the main heat transfer behavior between radiator and inside cabin. As long as the heat transfer behavior between radiator and outer space can be equivalently simulated in normal pressure, the thermal vacuum test can be substituted by the normal ground pressure thermal test. In this paper, an equivalent normal pressure thermal test method for the spacecraft single-phase fluid loop radiator is proposed. The heat radiation between radiator and outer space has been equivalently simulated by combination of a group of refrigerators and thermal electrical cooler (TEC array. By adjusting the heat rejection of each device, the relationship between heat flux and surface temperature of the radiator can be maintained. To verify this method, a validating system has been built up and the experiments have been carried out. The results indicate that the proposed equivalent ground thermal test method can simulate the heat rejection performance of radiator correctly and the temperature error between in-orbit theory value and experiment result of the radiator is less than 0.5 °C, except for the equipment startup period. This provides a potential method for the thermal test of space systems especially for extra-large spacecraft which employs single-phase fluid loop radiator as thermal control approach.

  4. Volumetric Spectroscopic Imaging of Glioblastoma Multiforme Radiation Treatment Volumes

    Energy Technology Data Exchange (ETDEWEB)

    Parra, N. Andres [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States); Maudsley, Andrew A. [Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida (United States); Gupta, Rakesh K. [Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, Haryana (India); Ishkanian, Fazilat; Huang, Kris [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States); Walker, Gail R. [Biostatistics and Bioinformatics Core Resource, Sylvester Cancer Center, University of Miami Miller School of Medicine, Miami, Florida (United States); Padgett, Kyle [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States); Department of Radiology, University of Miami Miller School of Medicine, Miami, Florida (United States); Roy, Bhaswati [Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, Haryana (India); Panoff, Joseph; Markoe, Arnold [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States); Stoyanova, Radka, E-mail: [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States)


    Purpose: Magnetic resonance (MR) imaging and computed tomography (CT) are used almost exclusively in radiation therapy planning of glioblastoma multiforme (GBM), despite their well-recognized limitations. MR spectroscopic imaging (MRSI) can identify biochemical patterns associated with normal brain and tumor, predominantly by observation of choline (Cho) and N-acetylaspartate (NAA) distributions. In this study, volumetric 3-dimensional MRSI was used to map these compounds over a wide region of the brain and to evaluate metabolite-defined treatment targets (metabolic tumor volumes [MTV]). Methods and Materials: Volumetric MRSI with effective voxel size of ∼1.0 mL and standard clinical MR images were obtained from 19 GBM patients. Gross tumor volumes and edema were manually outlined, and clinical target volumes (CTVs) receiving 46 and 60 Gy were defined (CTV{sub 46} and CTV{sub 60}, respectively). MTV{sub Cho} and MTV{sub NAA} were constructed based on volumes with high Cho and low NAA relative to values estimated from normal-appearing tissue. Results: The MRSI coverage of the brain was between 70% and 76%. The MTV{sub NAA} were almost entirely contained within the edema, and the correlation between the 2 volumes was significant (r=0.68, P=.001). In contrast, a considerable fraction of MTV{sub Cho} was outside of the edema (median, 33%) and for some patients it was also outside of the CTV{sub 46} and CTV{sub 60}. These untreated volumes were greater than 10% for 7 patients (37%) in the study, and on average more than one-third (34.3%) of the MTV{sub Cho} for these patients were outside of CTV{sub 60}. Conclusions: This study demonstrates the potential usefulness of whole-brain MRSI for radiation therapy planning of GBM and revealed that areas of metabolically active tumor are not covered by standard RT volumes. The described integration of MTV into the RT system will pave the way to future clinical trials investigating outcomes in patients treated based on

  5. Adaptive Optics for Satellite Imaging and Space Debris Ranging (United States)

    Bennet, F.; D'Orgeville, C.; Price, I.; Rigaut, F.; Ritchie, I.; Smith, C.

    Earth's space environment is becoming crowded and at risk of a Kessler syndrome, and will require careful management for the future. Modern low noise high speed detectors allow for wavefront sensing and adaptive optics (AO) in extreme circumstances such as imaging small orbiting bodies in Low Earth Orbit (LEO). The Research School of Astronomy and Astrophysics (RSAA) at the Australian National University have been developing AO systems for telescopes between 1 and 2.5m diameter to image and range orbiting satellites and space debris. Strehl ratios in excess of 30% can be achieved for targets in LEO with an AO loop running at 2kHz, allowing the resolution of small features (system developed at RSAA consists of a high speed EMCCD Shack-Hartmann wavefront sensor, a deformable mirror (DM), and realtime computer (RTC), and an imaging camera. The system works best as a laser guide star system but will also function as a natural guide star AO system, with the target itself being the guide star. In both circumstances tip-tilt is provided by the target on the imaging camera. The fast tip-tilt modes are not corrected optically, and are instead removed by taking images at a moderate speed (>30Hz) and using a shift and add algorithm. This algorithm can also incorporate lucky imaging to further improve the final image quality. A similar AO system for space debris ranging is also in development in collaboration with Electro Optic Systems (EOS) and the Space Environment Management Cooperative Research Centre (SERC), at the Mount Stromlo Observatory in Canberra, Australia. The system is designed for an AO corrected upward propagated 1064nm pulsed laser beam, from which time of flight information is used to precisely range the target. A 1.8m telescope is used for both propagation and collection of laser light. A laser guide star, Shack-Hartmann wavefront sensor, and DM are used for high order correction, and tip-tilt correction provided by reflected sunlight from the target. The

  6. Imaging and characterization of primary and secondary radiation in ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Granja, Carlos, E-mail:; Opalka, Lukas [Institute of Experimental and Applied Physics, Czech Technical University in Prague (Czech Republic); Martisikova, Maria; Gwosch, Klaus [German Cancer Research Center, Heidelberg (Germany); Jakubek, Jan [Advacam, Prague (Czech Republic)


    Imaging in ion beam therapy is an essential and increasingly significant tool for treatment planning and radiation and dose deposition verification. Efforts aim at providing precise radiation field characterization and online monitoring of radiation dose distribution. A review is given of the research and methodology of quantum-imaging, composition, spectral and directional characterization of the mixed-radiation fields in proton and light ion beam therapy developed by the IEAP CTU Prague and HIT Heidelberg group. Results include non-invasive imaging of dose deposition and primary beam online monitoring.

  7. Incorporating boundary conditions in the integral form of the radiative transfer equation for transcranial imaging

    DEFF Research Database (Denmark)

    Jha, Abhinav K.; Zhu, Yansong; Kang, Jin U.


    An integral Neumann-series implementation of the Radiative Transfer Equation that accounts for boundary conditions is proposed to simulate photon transport through tissue for transcranial optical imaging.......An integral Neumann-series implementation of the Radiative Transfer Equation that accounts for boundary conditions is proposed to simulate photon transport through tissue for transcranial optical imaging....

  8. Hounsfield unit recovery in clinical cone beam CT images of the thorax acquired for image guided radiation therapy

    DEFF Research Database (Denmark)

    Thing, Rune Slot; Bernchou, Uffe; Mainegra-Hing, Ernesto


    A comprehensive artefact correction method for clinical cone beam CT (CBCT) images acquired for image guided radiation therapy (IGRT) on a commercial system is presented. The method is demonstrated to reduce artefacts and recover CT-like Hounsfield units (HU) in reconstructed CBCT images of five...

  9. Wireless ultra-wide-band transmission prototype ASICs for low-power space and radiation applications

    Energy Technology Data Exchange (ETDEWEB)

    Gabrielli, A. [Istituto Nazionale di Fisica Nucleare (INFN), Bologna (Italy); Department of Physics and Astronomy, University of Bologna, Bologna (Italy); Crepaldi, M. [IIT@Polito Istituto Italiano Tecnologia, Politecnico di Torino, Torino (Italy); Demarchi, D. [IIT@Polito Istituto Italiano Tecnologia, Politecnico di Torino, Torino (Italy); Department of Electronics (DELEN), Politecnico di Torino, Torino (Italy); Motto Ros, P. [IIT@Polito Istituto Italiano Tecnologia, Politecnico di Torino, Torino (Italy); Villani, G. [Science Technology Facility Council (STFC), Rutherford Appleton Laboratory (RAL), Didcot (United Kingdom)


    The paper describes the design and the fabrication of a microelectronic circuit composed of a sensor, an oscillator, a modulator, a transmitter and an antenna. The chip embeds a custom radiation sensor, provided by the silicon foundry that has fabricated the prototypes, but in principle the entire system can read a general sensor, as long as a proper interface circuit is used. The natural application for this circuit is radiation monitoring but the low-power budget extends the applications to space where wireless readout circuits can be applied to any type of sensors, even if not radiation sensitive devices.

  10. The space-time outside a source of gravitational radiation: the axially symmetric null fluid

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, L. [Universidad Central de Venezuela, Escuela de Fisica, Facultad de Ciencias, Caracas (Venezuela, Bolivarian Republic of); Universidad de Salamanca, Instituto Universitario de Fisica Fundamental y Matematicas, Salamanca (Spain); Di Prisco, A. [Universidad Central de Venezuela, Escuela de Fisica, Facultad de Ciencias, Caracas (Venezuela, Bolivarian Republic of); Ospino, J. [Universidad de Salamanca, Departamento de Matematica Aplicada and Instituto Universitario de Fisica Fundamental y Matematicas, Salamanca (Spain)


    We carry out a study of the exterior of an axially and reflection symmetric source of gravitational radiation. The exterior of such a source is filled with a null fluid produced by the dissipative processes inherent to the emission of gravitational radiation, thereby representing a generalization of the Vaidya metric for axially and reflection symmetric space-times. The role of the vorticity, and its relationship with the presence of gravitational radiation is put in evidence. The spherically symmetric case (Vaidya) is, asymptotically, recovered within the context of the 1 + 3 formalism. (orig.)

  11. Web-based description of the space radiation environment using the Bethe-Bloch model

    CERN Document Server

    Cazzola, Emanuele; Lapenta, Giovanni


    Space weather is a rapidly growing area not only in scientific and engineering applications but also in physics education and in the interest of the public. We focus especially on space radiation and its impact on space exploration. The topic is highly interdisciplinary bringing together fundamental concepts of nuclear physics with aspects of radiation protection and space science. We present a new approach to presenting the topic by developing a web-based tool that combines some of the fundamental concepts from these two fields in a single tool that can be developed in the context of advanced secondary or undergraduate university education. We present DREADCode, an outreach or teaching tool to asses rapidly the current conditions of the radiation field in space. DREADCode uses the available data feeds from a number of ongoing space missions to produce a first order approximation of the dose an astronaut would receive during a mission of exploration in deep space. DREADcode is based on a intuitive GUI interfa...

  12. Investigation of Lithium Metal Hydride Materials for Mitigation of Deep Space Radiation (United States)

    Rojdev, Kristina; Atwell, William


    Radiation exposure to crew, electronics, and non-metallic materials is one of many concerns with long-term, deep space travel. Mitigating this exposure is approached via a multi-faceted methodology focusing on multi-functional materials, vehicle configuration, and operational or mission constraints. In this set of research, we are focusing on new multi-functional materials that may have advantages over traditional shielding materials, such as polyethylene. Metal hydride materials are of particular interest for deep space radiation shielding due to their ability to store hydrogen, a low-Z material known to be an excellent radiation mitigator and a potential fuel source. We have previously investigated 41 different metal hydrides for their radiation mitigation potential. Of these metal hydrides, we found a set of lithium hydrides to be of particular interest due to their excellent shielding of galactic cosmic radiation. Given these results, we will continue our investigation of lithium hydrides by expanding our data set to include dose equivalent and to further understand why these materials outperformed polyethylene in a heavy ion environment. For this study, we used HZETRN 2010, a one-dimensional transport code developed by NASA Langley Research Center, to simulate radiation transport through the lithium hydrides. We focused on the 1977 solar minimum Galactic Cosmic Radiation environment and thicknesses of 1, 5, 10, 20, 30, 50, and 100 g/cm2 to stay consistent with our previous studies. The details of this work and the subsequent results will be discussed in this paper.

  13. Radiation Measurements Performed with Active Detectors Relevant for Human Space Exploration. (United States)

    Narici, Livio; Berger, Thomas; Matthiä, Daniel; Reitz, Günther


    A reliable radiation risk assessment in space is a mandatory step for the development of countermeasures and long-duration mission planning in human spaceflight. Research in radiobiology provides information about possible risks linked to radiation. In addition, for a meaningful risk evaluation, the radiation exposure has to be assessed to a sufficient level of accuracy. Consequently, both the radiation models predicting the risks and the measurements used to validate such models must have an equivalent precision. Corresponding measurements can be performed both with passive and active devices. The former is easier to handle, cheaper, lighter, and smaller but they measure neither the time dependence of the radiation environment nor some of the details useful for a comprehensive radiation risk assessment. Active detectors provide most of these details and have been extensively used in the International Space Station. To easily access such an amount of data, a single point access is becoming essential. This review presents an ongoing work on the development of a tool that allows obtaining information about all relevant measurements performed with active detectors providing reliable inputs for radiation model validation.

  14. Persistence of Space Radiation Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts (United States)

    George, Kerry; Cucinotta, Francis A.


    Cytogenetic damage in astronaut's peripheral blood lymphocytes is a useful in vivo marker of space radiation induced damage. Moreover, if radiation induced chromosome translocations persist in peripheral blood lymphocytes for many years, as has been assumed, they could potentially be used to measure retrospective doses or prolonged low dose rate exposures. However, as more data becomes available, evidence suggests that the yield of translocations may decline with time after exposure, at least in the case of space radiation exposures. We present our latest follow-up measurements of chromosome aberrations in astronauts blood lymphocytes assessed by FISH painting and collected a various times beginning directly after return from space to several years after flight. For most individuals the analysis of individual time-courses for translocations revealed a temporal decline of yields with different half-lives. Since the level of stable aberrations depends on the interplay between natural loss of circulating T-lymphocytes and replenishment from the stem or progenitor cells, the differences in the rates of decay could be explained by inter-individual variation in lymphocyte turn over. Biodosimetry estimates derived from cytogenetic analysis of samples collected a few days after return to earth lie within the range expected from physical dosimetry. However, a temporal decline in yields may indicate complications with the use of stable aberrations for retrospective dose reconstruction, and the differences in the decay time may reflect individual variability in risk from space radiation exposure. In addition, limited data on multiple flights show a lack of correlation between time in space and translocation yields. Data from one crewmember who has participated in two separate long-duration space missions and has been followed up for over 10 years provides limited information on the effect of repeat flights and show a possible adaptive response to space radiation exposure.

  15. Space Radiation Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts (United States)

    George, K.; Cucinotta, F. A.


    Cytogenetic analysis of astronauts blood lymphocytes provides a direct in vivo measurement of space radiation damage, which takes into account individual radiosensitivity and considers the influence of microgravity and other stress conditions. We present our latest analyses of chromosome damage in astronauts blood lymphocytes assessed by fluorescence in situ hybridization (FISH) chromosome painting and collected at various times beginning directly after return from space to several years after flight. Dose was derived from frequencies of chromosome exchanges using preflight calibration curves, and the Relative Biological Effect (RBE) was estimated by comparison with individually measured physically absorbed doses. Values for average RBE were compared to the average quality factor (Q), from direct measurements of the lineal energy spectra using a tissue-equivalent proportional counter (TEPC) and radiation transport codes. Results prove that cytogenetic biodosimetry analyses on blood collected within a week or two of return from space provides a reliable estimate of equivalent radiation dose and risk after protracted exposure to space radiation of a few months or more. However, data collected several months or years after flight suggests that the yield of chromosome translocations may decline with time after the mission, indicating that retrospective doses may be more difficult to estimate. In addition, limited data on multiple flights show a lack of correlation between time in space and translocation yields. Data from one crewmember, who has participated in two separate long-duration space missions and has been followed up for over 10 years, provide limited information on the effect of repeat flights and show a possible adaptive response to space radiation exposure.

  16. Assessment of the Radiation Enclosure Models in SPACE and RELAP5 with GOTA Test 27

    Energy Technology Data Exchange (ETDEWEB)

    Lee, T. B.; Lee, G. W.; Choi, T. S. [KEPCO, Daejeon (Korea, Republic of)


    SPACE (Safety and Performance Analysis Code) for nuclear power plant has been developed to calculate the transient thermal-hydraulic response of PWRs that can contain multiple types of fluids. Without explaining 3-D effects such as the change of fuel rod/guide tube thermal behavior as a result of the radiation heat transfer, the 1-D code could predict an unrealistically high peak clad temperature. A useful function to simulate the wall-to-wall radiation heat transfer is implemented in the SPACE and RELAP5 codes. This paper discusses the assessment results of the radiation enclosure model of SPACE and RELAP5. The capability of handling wall-to-wall radiation problem of the SPACE and the RELAP5 codes has been evaluated using the experimental data from the GOTA test facility. At the top of the bundle, the maximum errors of SPACE and RELAP5 are less than 1.6% and 2.3%, respectively. As noted, there is a small discrepancy between the calculated results and experimental data except for the predictions near the top of the test section. The SPACE code is based on the version 2.16 distributed by KHNP. In order to perform the simulation of the GOTA test 27, it was necessary to modify the SPACE code. There was the subroutine for an input process corresponding to the radiation model, the inp{sub c}heck function of the RadEncData Class, contained in a vulnerable algorithm to figure out the reciprocity rule of the view factor.

  17. Discrete Event Simulation Model of the Polaris 2.1 Gamma Ray Imaging Radiation Detection Device (United States)


    Polaris given that the Polaris continues to make improvements not just in GPS and WIFI capabilities but in capture rates for different radiation ...release; distribution is unlimited DISCRETE EVENT SIMULATION MODEL OF THE POLARIS 2.1 GAMMA RAY IMAGING RADIATION DETECTION DEVICE by Andres T...OF THE POLARIS 2.1 GAMMA RAY IMAGING RADIATION DETECTION DEVICE 5. FUNDING NUMBERS 6. AUTHOR(S) Andres T. Juarez III 7. PERFORMING ORGANIZATION

  18. Space Radar Image of Colima Volcano, Jalisco, Mexico (United States)


    This is an image of the Colima volcano in Jalisco, Mexico, a vigorously active volcano that erupted as recently as July 1994. The eruption partially destroyed a lava dome at the summit and deposited a new layer of ash on the volcano's southern slopes. Surrounding communities face a continuing threat of ash falls and volcanic mudflows from the volcano, which has been designated one of 15 high-risk volcanoes for scientific study during the next decade. This image was acquired by the Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on its 24th orbit on October 1, 1994. The image is centered at 19.4 degrees north latitude, 103.7 degrees west longitude. The area shown is approximately 35.7 kilometers by 37.5 kilometers (22 miles by 23 miles). This single-frequency, multi-polarized SIR-C image shows: red as L-band horizontally transmitted and received; green as L-band horizontally transmitted and vertically received; and blue as the ratio of the two channels. The summit area appears orange and the recent deposits fill the valleys along the south and southwest slopes. Observations from space are helping scientists understand the behavior of dangerous volcanoes and will be used to mitigate the effects of future eruptions on surrounding populations. Spaceborne Imaging Radar-C and X-band Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves, allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: the L-band (24 cm), the C-band (6 cm) and the X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground studies, will give scientists clearer insights into those environmental changes which are caused by nature

  19. OLTARIS: An Efficient Web-Based Tool for Analyzing Materials Exposed to Space Radiation (United States)

    Slaba, Tony; McMullen, Amelia M.; Thibeault, Sheila A.; Sandridge, Chris A.; Clowdsley, Martha S.; Blatting, Steve R.


    The near-Earth space radiation environment includes energetic galactic cosmic rays (GCR), high intensity proton and electron belts, and the potential for solar particle events (SPE). These sources may penetrate shielding materials and deposit significant energy in sensitive electronic devices on board spacecraft and satellites. Material and design optimization methods may be used to reduce the exposure and extend the operational lifetime of individual components and systems. Since laboratory experiments are expensive and may not cover the range of particles and energies relevant for space applications, such optimization may be done computationally with efficient algorithms that include the various constraints placed on the component, system, or mission. In the present work, the web-based tool OLTARIS (On-Line Tool for the Assessment of Radiation in Space) is presented, and the applicability of the tool for rapidly analyzing exposure levels within either complicated shielding geometries or user-defined material slabs exposed to space radiation is demonstrated. An example approach for material optimization is also presented. Slabs of various advanced multifunctional materials are defined and exposed to several space radiation environments. The materials and thicknesses defining each layer in the slab are then systematically adjusted to arrive at an optimal slab configuration.

  20. Introduction to the special issue on molecular imaging in radiation biology. (United States)

    Humm, John L; Dewhirst, Mark W; Bhujwalla, Zaver M


    Molecular imaging is an evolving science that is concerned with the development of novel imaging probes and biomarkers that can be used to non-invasively image molecular and cellular processes. This special issue approaches molecular imaging in the context of radiation research, focusing on biomarkers and imaging methods that provide measurable signals that can assist in the quantification of radiation-induced effects of living systems at the physical, chemical and biological levels. The potential to image molecular changes in response to a radiation insult opens new and exciting opportunities for a more profound understanding of radiation biology, with the possibility of translation of these techniques to radiotherapy practice. This special issue brings together 14 reviews dedicated to the use of molecular imaging in the field of radiation research. The initial three reviews are introductory overviews of the key molecular imaging modalities: magnetic resonance, nuclear and optical. This is followed by 11 reviews each focusing on a specialist area within the field of radiation research. These include: hypoxia and perfusion, tissue metabolism, normal tissue injury, cell death and viability, receptor targeting and nanotechnology, reporter genes, reactive oxygen species (ROS), and biological dosimetry. Over the preceding decade, molecular imaging brought significant new advances to our understanding of every area of radiation biology. This special issue shows us these advances and points to the vibrant future of our field armed with these new capabilities.

  1. Probability of Causation for Space Radiation Carcinogenesis Following International Space Station, Near Earth Asteroid, and Mars Missions (United States)

    Cucinotta, Francis A.; Kim, Myung-Hee Y.; Chappell, Lori J.


    Cancer risk is an important concern for International Space Station (ISS) missions and future exploration missions. An important question concerns the likelihood of a causal association between a crew members radiation exposure and the occurrence of cancer. The probability of causation (PC), also denoted as attributable risk, is used to make such an estimate. This report summarizes the NASA model of space radiation cancer risks and uncertainties, including improvements to represent uncertainties in tissue-specific cancer incidence models for never-smokers and the U.S. average population. We report on tissue-specific cancer incidence estimates and PC for different post-mission times for ISS and exploration missions. An important conclusion from our analysis is that the NASA policy to limit the risk of exposure-induced death to 3% at the 95% confidence level largely ensures that estimates of the PC for most cancer types would not reach a level of significance. Reducing uncertainties through radiobiological research remains the most efficient method to extend mission length and establish effective mitigators for cancer risks. Efforts to establish biomarkers of space radiation-induced tumors and to estimate PC for rarer tumor types are briefly discussed.

  2. Body MR Imaging: Artifacts, k-Space, and Solutions (United States)

    Seethamraju, Ravi T.; Patel, Pritesh; Hahn, Peter F.; Kirsch, John E.; Guimaraes, Alexander R.


    Body magnetic resonance (MR) imaging is challenging because of the complex interaction of multiple factors, including motion arising from respiration and bowel peristalsis, susceptibility effects secondary to bowel gas, and the need to cover a large field of view. The combination of these factors makes body MR imaging more prone to artifacts, compared with imaging of other anatomic regions. Understanding the basic MR physics underlying artifacts is crucial to recognizing the trade-offs involved in mitigating artifacts and improving image quality. Artifacts can be classified into three main groups: (a) artifacts related to magnetic field imperfections, including the static magnetic field, the radiofrequency (RF) field, and gradient fields; (b) artifacts related to motion; and (c) artifacts arising from methods used to sample the MR signal. Static magnetic field homogeneity is essential for many MR techniques, such as fat saturation and balanced steady-state free precession. Susceptibility effects become more pronounced at higher field strengths and can be ameliorated by using spin-echo sequences when possible, increasing the receiver bandwidth, and aligning the phase-encoding gradient with the strongest susceptibility gradients, among other strategies. Nonuniformities in the RF transmit field, including dielectric effects, can be minimized by applying dielectric pads or imaging at lower field strength. Motion artifacts can be overcome through respiratory synchronization, alternative k-space sampling schemes, and parallel imaging. Aliasing and truncation artifacts derive from limitations in digital sampling of the MR signal and can be rectified by adjusting the sampling parameters. Understanding the causes of artifacts and their possible solutions will enable practitioners of body MR imaging to meet the challenges of novel pulse sequence design, parallel imaging, and increasing field strength. ©RSNA, 2015 PMID:26207581

  3. Snapshots from Space: Citizen Participation in Space Missions Through Image Processing (United States)

    Lakdawalla, E. S.; Bell, J. F.


    For six years, members of the public have been able to ride along with the rovers and cruise with Cassini on their daily journeys across Mars and through the Saturn system by browsing the daily downlinks of raw images posted to the missions' websites. An international community of amateur image processors has grown up around these image libraries, people who not only browse and discuss the photos but also process them into color versions, mosaics, and animations. Until recently, only a few of these amateurs have been able to push beyond the raw image websites -- which post reduced-quality versions of the images, unsuitable for science -- into the actual archived science data at the Planetary Data System. However, recent upgrades to search tools at the various Planetary Data System Nodes have largely removed the barriers (such as arcane file formats) that previously prevented members of the public from understanding how to access science data. Now increasing number of citizen scientists are making discoveries in these image data, while creating beautiful images that display space destinations as a human observer would see them.

  4. Design of a space-based infrared imaging interferometer (United States)

    Hart, Michael; Hope, Douglas; Romeo, Robert


    Present space-based optical imaging sensors are expensive. Launch costs are dictated by weight and size, and system design must take into account the low fault tolerance of a system that cannot be readily accessed once deployed. We describe the design and first prototype of the space-based infrared imaging interferometer (SIRII) that aims to mitigate several aspects of the cost challenge. SIRII is a six-element Fizeau interferometer intended to operate in the short-wave and midwave IR spectral regions over a 6×6 mrad field of view. The volume is smaller by a factor of three than a filled-aperture telescope with equivalent resolving power. The structure and primary optics are fabricated from light-weight space-qualified carbon fiber reinforced polymer; they are easy to replicate and inexpensive. The design is intended to permit one-time alignment during assembly, with no need for further adjustment once on orbit. A three-element prototype of the SIRII imager has been constructed with a unit telescope primary mirror diameter of 165 mm and edge-to-edge baseline of 540 mm. The optics, structure, and interferometric signal processing principles draw on experience developed in ground-based astronomical applications designed to yield the highest sensitivity and resolution with cost-effective optical solutions. The initial motivation for the development of SIRII was the long-term collection of technical intelligence from geosynchronous orbit, but the scalable nature of the design will likely make it suitable for a range of IR imaging scenarios.

  5. Image-Guided Radiation Therapy: the potential for imaging science research to improve cancer treatment outcomes (United States)

    Williamson, Jeffrey


    The role of medical imaging in the planning and delivery of radiation therapy (RT) is rapidly expanding. This is being driven by two developments: Image-guided radiation therapy (IGRT) and biological image-based planning (BIBP). IGRT is the systematic use of serial treatment-position imaging to improve geometric targeting accuracy and/or to refine target definition. The enabling technology is the integration of high-performance three-dimensional (3D) imaging systems, e.g., onboard kilovoltage x-ray cone-beam CT, into RT delivery systems. IGRT seeks to adapt the patient's treatment to weekly, daily, or even real-time changes in organ position and shape. BIBP uses non-anatomic imaging (PET, MR spectroscopy, functional MR, etc.) to visualize abnormal tissue biology (angiogenesis, proliferation, metabolism, etc.) leading to more accurate clinical target volume (CTV) delineation and more accurate targeting of high doses to tissue with the highest tumor cell burden. In both cases, the goal is to reduce both systematic and random tissue localization errors (2-5 mm for conventional RT) conformality so that planning target volume (PTV) margins (varying from 8 to 20 mm in conventional RT) used to ensure target volume coverage in the presence of geometric error, can be substantially reduced. Reduced PTV expansion allows more conformal treatment of the target volume, increased avoidance of normal tissue and potential for safe delivery of more aggressive dose regimens. This presentation will focus on the imaging science challenges posed by the IGRT and BIBP. These issues include: Development of robust and accurate nonrigid image-registration (NIR) tools: Extracting locally nonlinear mappings that relate, voxel-by-voxel, one 3D anatomic representation of the patient to differently deformed anatomies acquired at different time points, is essential if IGRT is to move beyond simple translational treatment plan adaptations. NIR is needed to map segmented and labeled anatomy from the

  6. Simulated Space Radiation and Weightlessness: Vascular-Bone Coupling Mechanisms to Preserve Skeletal Health (United States)

    Alwood, J. S.; Limoli, C. L.; Delp, M. D.; Castillo, A. B.; Globus, R. K.


    Weightlessness causes a cephalad fluid shift and reduction in mechanical stimulation, adversely affecting both cortical and trabecular bone tissue in astronauts. In rodent models of weightlessness, the onset of bone loss correlates with reduced skeletal perfusion, reduced and rarified vasculature and lessened vasodilation, which resembles blood-bone symbiotic events that can occur with fracture repair and aging. These are especially serious risks for long term, exploration class missions when astronauts will face the challenge of increased exposure to space radiation and abrupt transitions between different gravity environments upon arrival and return. Previously, we found using the mouse hindlimb unloading model and exposure to heavy ion radiation, both disuse and irradiation cause an acute bone loss that was associated with a reduced capacity to produce bone-forming osteoblasts from the bone marrow. Together, these findings led us to hypothesize that exposure to space radiation exacerbates weightlessness-induced bone loss and impairs recovery upon return, and that treatment with anti-oxidants may mitigate these effects. The specific aims of this recently awarded grant are to: AIM 1 Determine the functional and structural consequences of prolonged weightlessness and space radiation (simulated spaceflight) for bone and skeletal vasculature in the context of bone cell function and oxidative stress. AIM 2 Determine the extent to which an anti-oxidant protects against weightlessness and space radiation-induced bone loss and vascular dysfunction. AIM 3 Determine how space radiation influences later skeletal and vasculature recovery from prolonged weightlessness and the potential of anti-oxidants to preserve adaptive remodeling.

  7. Space Radar Image of Rabaul Volcano, New Guinea (United States)


    This is a radar image of the Rabaul volcano on the island of New Britain, Papua, New Guinea taken almost a month after its September 19, 1994, eruption that killed five people and covered the town of Rabaul and nearby villages with up to 75 centimeters (30 inches) of ash. More than 53,000 people have been displaced by the eruption. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) aboard the space shuttle Endeavour on its 173rd orbit on October 11, 1994. This image is centered at 4.2 degrees south latitude and 152.2 degrees east longitude in the southwest Pacific Ocean. The area shown is approximately 21 kilometers by 25 kilometers (13 miles by 15.5 miles). North is toward the upper right. The colors in this image were obtained using the following radar channels: red represents the L-band (horizontally transmitted and received); green represents the L-band (horizontally transmitted and vertically received); blue represents the C-band (horizontally transmitted and vertically received). Most of the Rabaul volcano is underwater and the caldera (crater) creates Blanche Bay, the semi-circular body of water that occupies most of the center of the image. Volcanic vents within the caldera are visible in the image and include Vulcan, on a peninsula on the west side of the bay, and Rabalanakaia and Tavurvur (the circular purple feature near the mouth of the bay) on the east side. Both Vulcan and Tavurvur were active during the 1994 eruption. Ash deposits appear red-orange on the image, and are most prominent on the south flanks of Vulcan and north and northwest of Tavurvur. A faint blue patch in the water in the center of the image is a large raft of floating pumice fragments that were ejected from Vulcan during the eruption and clog the inner bay. Visible on the east side of the bay are the grid-like patterns of the streets of Rabaul and an airstrip, which appears as a dark northwest-trending band at the right-center of

  8. Space Radar Image of the Lost City of Ubar (United States)


    This is a radar image of the region around the site of the lost city of Ubar in southern Oman, on the Arabian Peninsula. The ancient city was discovered in 1992 with the aid of remote sensing data. Archeologists believe Ubar existed from about 2800 B.C. to about 300 A.D. and was a remote desert outpost where caravans were assembled for the transport of frankincense across the desert. This image was acquired on orbit 65 of space shuttle Endeavour on April 13, 1994 by the Spaceborne Imaging Radar C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR). The SIR-C image shown is centered at 18.4 degrees north latitude and 53.6 degrees east longitude. The image covers an area about 50 by 100 kilometers (31 miles by 62 miles). The image is constructed from three of the available SIR-C channels and displays L-band, HH (horizontal transmit and receive) data as red, C-band HH as blue, and L-band HV (horizontal transmit, vertical receive) as green. The prominent magenta colored area is a region of large sand dunes, which are bright reflectors at both L-and C-band. The prominent green areas (L-HV) are rough limestone rocks, which form a rocky desert floor. A major wadi, or dry stream bed, runs across the middle of the image and is shown largely in white due to strong radar scattering in all channels displayed (L and C HH, L-HV). The actual site of the fortress of the lost city of Ubar, currently under excavation, is near the Wadi close to the center of the image. The fortress is too small to be detected in this image. However, tracks leading to the site, and surrounding tracks, appear as prominent, but diffuse, reddish streaks. These tracks have been used in modern times, but field investigations show many of these tracks were in use in ancient times as well. Mapping of these tracks on regional remote sensing images was a key to recognizing the site as Ubar in 1992. This image, and ongoing field investigations, will help shed light on a little known early civilization. Spaceborne

  9. Improved Understanding of Space Radiation Effects on Exploration Electronics by Advanced Modeling of Nanoscale Devices and Novel Materials Project (United States)

    National Aeronautics and Space Administration — Future NASA space exploration missions will use nanometer-scale electronic technologies which call for a shift in how radiation effects in such devices and materials...

  10. Coupled Radiation Transport/Thermal Analysis of the Radiation Shield for a Space Nuclear Reactor. (United States)


    thermal analysis of radiation shield are those of Beiriger (1968) and Thompson and Schwab (1969). Belriger (1968) conducted a thermal analysis of Pb-W...regarding how the temperature values were generated were not reported. Thompson and Schwab (1969) examined the accuracy of several neu- tronic models in...Publishing Company, Inc., 1984. Bathe, Klaus -Jurgen, Finite Element Procedures in Engineering Analy- sis, New Jersey: Prentice Hall, Inc., 1982. deckurts, K.H



    This is the first direct image of a star other than the Sun, made with NASA's Hubble Space Telescope. Called Alpha Orionis, or Betelgeuse, it is a red supergiant star marking the shoulder of the winter constellation Orion the Hunter (diagram at right). The Hubble image reveals a huge ultraviolet atmosphere with a mysterious hot spot on the stellar behemoth's surface. The enormous bright spot, more than ten times the diameter of Earth, is at least 2,000 Kelvin degrees hotter than the surface of the star. The image suggests that a totally new physical phenomenon may be affecting the atmospheres of some stars. Follow-up observations will be needed to help astronomers understand whether the spot is linked to oscillations previously detected in the giant star, or whether it moves systematically across the star's surface under the grip of powerful magnetic fields. The observations were made by Andrea Dupree of the Harvard- Smithsonian Center for Astrophysics in Cambridge, MA, and Ronald Gilliland of the Space Telescope Science Institute in Baltimore, MD, who announced their discovery today at the 187th meeting of the American Astronomical Society in San Antonio, Texas. The image was taken in ultraviolet light with the Faint Object Camera on March 3, 1995. Hubble can resolve the star even though the apparent size is 20,000 times smaller than the width of the full Moon -- roughly equivalent to being able to resolve a car's headlights at a distance of 6,000 miles. Betelgeuse is so huge that, if it replaced the Sun at the center of our Solar System, its outer atmosphere would extend past the orbit of Jupiter (scale at lower left). Credit: Andrea Dupree (Harvard-Smithsonian CfA), Ronald Gilliland (STScI), NASA and ESA Image files in GIF and JPEG format and captions may be accessed on Internet via anonymous ftp from in /pubinfo.

  12. Cone-beam CT for breast imaging: Radiation dose, breast coverage, and image quality. (United States)

    O'Connell, Avice; Conover, David L; Zhang, Yan; Seifert, Posy; Logan-Young, Wende; Lin, Chuen-Fu Linda; Sahler, Lawrence; Ning, Ruola


    The primary objectives of this pilot study were to evaluate the radiation dose, breast coverage, and image quality of cone-beam breast CT compared with a conventional mammographic examination. Image quality analysis was focused on the concordance of cone-beam breast CT with conventional mammography in terms of mammographic findings. This prospective study was performed from July 2006 through August 2008. Twenty-three women were enrolled who met the inclusion criteria, which were age 40 years or older with final BI-RADS assessment category 1 or 2 lesions on conventional mammograms within the previous 6 months. The breasts were imaged with a flat-panel detector-based cone-beam CT system, and the images were reviewed with a 3D visualization system. Cone-beam breast CT image data sets and the corresponding mammograms were reviewed by three qualified mammographers. The parameters assessed and compared in this pilot study were radiation dose, breast tissue coverage, and image quality, including detectability of masses and calcifications. The mammograms and cone-beam breast CT images were independently reviewed side by side, and the reviewers were not blinded to the other technique. The observed agreement and Cohen's kappa were used to evaluate agreement between the mammographic and cone-beam breast CT findings and interobserver agreement. Each subject responded to a questionnaire on multiple parameters, including comfort of the cone-beam breast CT examination compared with mammography. For a conventional mammographic examination, the average glandular radiation dose ranged from 2.2 to 15 mGy (mean, 6.5 [SD, 2.9] mGy). For cone-beam breast CT, the average glandular dose ranged from 4 to 12.8 mGy (mean, 8.2 [SD, 1.4] mGy). The average glandular dose from cone-beam breast CT was generally within the range of that from conventional mammography. For heterogeneously dense and extremely dense breasts, the difference between the mean dose of conventional mammography and that of

  13. Radiation change in normal organs: an overview of body imaging

    Energy Technology Data Exchange (ETDEWEB)

    Libshitz, H.I. [Dept. of Diagnostic Radiology, M.D. Anderson Cancer Center, Texas Univ., Houston, TX (United States); DuBrow, R.A. [Dept. of Diagnostic Radiology, M.D. Anderson Cancer Center, Texas Univ., Houston, TX (United States); Loyer, E.M. [Dept. of Diagnostic Radiology, M.D. Anderson Cancer Center, Texas Univ., Houston, TX (United States); Charnsangavej, C. [Dept. of Diagnostic Radiology, M.D. Anderson Cancer Center, Texas Univ., Houston, TX (United States)


    Radiotherapy causes changes in a treated malignancy and the surrounding normal tissue which must be included in the radiation fields. Awareness of the expected appearance of these changes frequently permits differentiation of them from superimposed infection, recurrent malignancy, radiation-induced tumors, and the other true complications of radiation therapy. Radiotherapy changes are a function of the tissue volume treated, field shape, total dose and how it was delivered, time from completion of therapy, and the possible effect of other therapies. Timing of radiation changes varies in the different organs. Acute radiation pneumonitis is generally seen approximately 2 months after completion of radiotherapy, but radiation pericarditis not until 6-9 months after therapy. Radiation-induced sarcomas do not develop on average until 10-15 years after radiation therapy. An overview of expected findings and complications in the lungs, heart, gastrointestinal tract, genitourinary tract, and bones is presented. (orig.)

  14. Feasibility study of an image slicer for future space application (United States)

    Calcines, A.; Ichimoto, K.


    This communication presents the feasibility study of an image slicer for future space missions, especially for the integral field unit (IFU) of the SUVIT (Solar UV-Visible-IR telescope) spectro-polarimeter on board the Japanese-led solar space mission Solar-C as a backup option. The MuSICa (Multi-Slit Image slicer based on collimator-Camera) image slicer concept, originally developed for the European Solar Telescope, has been adapted to the SUVIT requirements. The IFU will reorganizes a 2-D field of view of 10 x 10 arcsec2 into three slits of 0.18 arcsec width by 185.12 arcsec length using flat slicer mirrors of 100 μm width. The layout of MuSICa for Solar-C is telecentric and offers an optical quality limited by diffraction. The entrance for the SUVIT spectro-polarimeter is composed by the three IFU slits and one ordinal long slit to study, using high resolution spectro-polarimetry, the solar atmosphere (Photosphere and Chromosphere) within a spectral range between 520 nm (optionally 280 nm) and 1,100 nm.

  15. A space weather index for the radiation field at aviation altitudes

    Directory of Open Access Journals (Sweden)

    Meier Matthias M.


    Full Text Available The additional dose contribution to the radiation exposure at aviation altitudes during Solar Particle Events (SPEs has been a matter of concern for many years. After the Halloween storms in 2003 several airlines began to implement mitigation measures such as rerouting and lowering flight altitudes in response to alerts on the NOAA S-scale regarding solar radiation storms. These alerts are based on the integral proton flux above 10 MeV measured aboard the corresponding GOES-satellite which is operated outside the Earth’s atmosphere in a geosynchronous orbit. This integral proton flux has, however, been proved to be an insufficient parameter to apply to the radiation field at aviation altitudes without an accompanying analysis of the shape of the energy spectrum. Consequently, false alarms and corresponding disproportionate reactions ensued. Since mitigating measures can be quite cost-intensive, there has been a demand for appropriate space weather information among responsible airline managers for about a decade. Against this background, we propose the introduction of a new Space Weather index D, based on dose rates at aviation altitudes produced by solar protons during solar radiation storms, as the relevant parameter for the assessment of corresponding radiation exposure. The Space Weather index D is a natural number given by a graduated table of ranges of dose rates in ascending order which is derived by an equation depending on the dose rate of solar protons.

  16. Mathematical Analysis of Space Radiator Segmenting for Increased Reliability and Reduced Mass (United States)

    Juhasz, Albert J.


    Spacecraft for long duration deep space missions will need to be designed to survive micrometeoroid bombardment of their surfaces some of which may actually be punctured. To avoid loss of the entire mission the damage due to such punctures must be limited to small, localized areas. This is especially true for power system radiators, which necessarily feature large surface areas to reject heat at relatively low temperature to the space environment by thermal radiation. It may be intuitively obvious that if a space radiator is composed of a large number of independently operating segments, such as heat pipes, a random micrometeoroid puncture will result only in the loss of the punctured segment, and not the entire radiator. Due to the redundancy achieved by independently operating segments, the wall thickness and consequently the weight of such segments can be drastically reduced. Probability theory is used to estimate the magnitude of such weight reductions as the number of segments is increased. An analysis of relevant parameter values required for minimum mass segmented radiators is also included.

  17. New Efficient Detector for Radiation Therapy Imaging using Gas Electron Multipliers


    Östling, Janina


    Currently film is being replaced by electronic detectors for portal imaging in radiation therapy. This development offers obvious advantages such as on-line quality assurance and digital images that can easily be accessed, processed and communicated. In spite of the improvements, the image quality has not been significantly enhanced, partly since the quantum efficiency compared to film is essentially the same, and the new electronic devices also suffer from sensitivity to the harsh radiation ...

  18. Simulation and measurement of total ionizing dose radiation induced image lag increase in pinned photodiode CMOS image sensors (United States)

    Liu, Jing; Chen, Wei; Wang, Zujun; Xue, Yuanyuan; Yao, Zhibin; He, Baoping; Ma, Wuying; Jin, Junshan; Sheng, Jiangkun; Dong, Guantao


    This paper presents an investigation of total ionizing dose (TID) induced image lag sources in pinned photodiodes (PPD) CMOS image sensors based on radiation experiments and TCAD simulation. The radiation experiments have been carried out at the Cobalt -60 gamma-ray source. The experimental results show the image lag degradation is more and more serious with increasing TID. Combining with the TCAD simulation results, we can confirm that the junction of PPD and transfer gate (TG) is an important region forming image lag during irradiation. These simulations demonstrate that TID can generate a potential pocket leading to incomplete transfer.

  19. Simulation and measurement of total ionizing dose radiation induced image lag increase in pinned photodiode CMOS image sensors

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jing [School of Materials Science and Engineering, Xiangtan University, Hunan (China); State Key Laboratory of Intense Pulsed Irradiation Simulation and Effect, Northwest Institute of Nuclear Technology, P.O.Box 69-10, Xi’an (China); Chen, Wei, E-mail: [State Key Laboratory of Intense Pulsed Irradiation Simulation and Effect, Northwest Institute of Nuclear Technology, P.O.Box 69-10, Xi’an (China); Wang, Zujun, E-mail: [State Key Laboratory of Intense Pulsed Irradiation Simulation and Effect, Northwest Institute of Nuclear Technology, P.O.Box 69-10, Xi’an (China); Xue, Yuanyuan; Yao, Zhibin; He, Baoping; Ma, Wuying; Jin, Junshan; Sheng, Jiangkun; Dong, Guantao [State Key Laboratory of Intense Pulsed Irradiation Simulation and Effect, Northwest Institute of Nuclear Technology, P.O.Box 69-10, Xi’an (China)


    This paper presents an investigation of total ionizing dose (TID) induced image lag sources in pinned photodiodes (PPD) CMOS image sensors based on radiation experiments and TCAD simulation. The radiation experiments have been carried out at the Cobalt −60 gamma-ray source. The experimental results show the image lag degradation is more and more serious with increasing TID. Combining with the TCAD simulation results, we can confirm that the junction of PPD and transfer gate (TG) is an important region forming image lag during irradiation. These simulations demonstrate that TID can generate a potential pocket leading to incomplete transfer.

  20. Space Radiation Heart Disease Risk Estimates for Lunar and Mars Missions (United States)

    Cucinotta, Francis A.; Chappell, Lori; Kim, Myung-Hee


    The NASA Space Radiation Program performs research on the risks of late effects from space radiation for cancer, neurological disorders, cataracts, and heart disease. For mortality risks, an aggregate over all risks should be considered as well as projection of the life loss per radiation induced death. We report on a triple detriment life-table approach to combine cancer and heart disease risks. Epidemiology results show extensive heterogeneity between populations for distinct components of the overall heart disease risks including hypertension, ischaemic heart disease, stroke, and cerebrovascular diseases. We report on an update to our previous heart disease estimates for Heart disease (ICD9 390-429) and Stroke (ICD9 430-438), and other sub-groups using recent meta-analysis results for various exposed radiation cohorts to low LET radiation. Results for multiplicative and additive risk transfer models are considered using baseline rates for US males and female. Uncertainty analysis indicated heart mortality risks as low as zero, assuming a threshold dose for deterministic effects, and projections approaching one-third of the overall cancer risk. Medan life-loss per death estimates were significantly less than that of solid cancer and leukemias. Critical research questions to improve risks estimates for heart disease are distinctions in mechanisms at high doses (>2 Gy) and low to moderate doses (<2 Gy), and data and basic understanding of radiation doserate and quality effects, and individual sensitivity.

  1. Development of a Fast and Highly Efficient Gas Ionization Chamber For Patient Imaging and Dosimetry in Radiation Therapy

    CERN Document Server

    Hinderler, R; Keller, H; Mackie, T R


    In radiation therapy of cancer, more accurate delivery techniques spur the need for improved patient imaging during treatment. To this purpose, the megavoltage radiation protocol that is used for treatment is also used for imaging.

  2. Development of Fast and Highly Efficient Gas Ionization Chamber For Patient Imaging and Dosimetry in Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    R. Hinderler; H. Keller; T.R. Mackie; M.L. Corradini


    In radiation therapy of cancer, more accurate delivery techniques spur the need for improved patient imaging during treatment. To this purpose, the megavoltage radiation protocol that is used for treatment is also used for imaging.

  3. Infinite space Green’s function of the time-dependent radiative transfer equation (United States)

    Liemert, André; Kienle, Alwin


    This study contains the derivation of an infinite space Green’s function of the time-dependent radiative transfer equation in an anisotropically scattering medium based on analytical approaches. The final solutions are analytical regarding the time variable and given by a superposition of real and complex exponential functions. The obtained expressions were successfully validated with Monte Carlo simulations. PMID:22435101

  4. Infinite space Green's function of the time-dependent radiative transfer equation. (United States)

    Liemert, André; Kienle, Alwin


    This study contains the derivation of an infinite space Green's function of the time-dependent radiative transfer equation in an anisotropically scattering medium based on analytical approaches. The final solutions are analytical regarding the time variable and given by a superposition of real and complex exponential functions. The obtained expressions were successfully validated with Monte Carlo simulations.

  5. Modeling of Space Radiation Exposure Estimation Program for Pilots, Crew and Passengers on Commercial Flights

    Directory of Open Access Journals (Sweden)

    Junga Hwang


    Full Text Available There has been a rapid increase of the concern on the space radiation effect on pilots, crew and passengers at the commercial aircraft altitude (~ 10 km recently. It is because domestic airline companies, Korean Air and Asiana Airlines have just begun operating the polar routes over the North Pole since 2006 and 2009 respectively. CARI-6 and CARI-6M are commonly used space radiation estimation programs which are provided officially by the U.S. federal aviation administration (FAA. In this paper, the route doses and the annual radiation doses for Korean pilots and cabin crew were estimated by using CARI-6M based on 2012 flight records. Also the modeling concept was developed for our own space radiation estimation program which is composed of GEANT4 and NRLMSIS00 models. The GEANT4 model is used to trace the incident particle transports in the atmosphere and the NRLMSIS00 model is used to get the background atmospheric densities of various neutral atoms at the aircraft altitude. Also presented are the results of simple integration tests of those models and the plan to include the space weather variations through the solar proton event (SPE prediction model such as UMASEP and the galactic cosmic ray (GCR prediction model such as Badhwar-O’Neill 2010.

  6. Final report on LDRD project 52722 : radiation hardened optoelectronic components for space-based applications.

    Energy Technology Data Exchange (ETDEWEB)

    Hargett, Terry W. (L& M Technologies, Inc.); Serkland, Darwin Keith; Blansett, Ethan L.; Geib, Kent Martin; Sullivan, Charles Thomas; Hawkins, Samuel D.; Wrobel, Theodore Frank; Keeler, Gordon Arthur; Klem, John Frederick; Medrano, Melissa R.; Peake, Gregory Merwin; Karpen, Gary D.; Montano, Victoria A. (L& M Technologies, Inc.)


    This report describes the research accomplishments achieved under the LDRD Project 'Radiation Hardened Optoelectronic Components for Space-Based Applications.' The aim of this LDRD has been to investigate the radiation hardness of vertical-cavity surface-emitting lasers (VCSELs) and photodiodes by looking at both the effects of total dose and of single-event upsets on the electrical and optical characteristics of VCSELs and photodiodes. These investigations were intended to provide guidance for the eventual integration of radiation hardened VCSELs and photodiodes with rad-hard driver and receiver electronics from an external vendor for space applications. During this one-year project, we have fabricated GaAs-based VCSELs and photodiodes, investigated ionization-induced transient effects due to high-energy protons, and measured the degradation of performance from both high-energy protons and neutrons.

  7. Exploring innovative radiation shielding approaches in space: A material and design study for a wearable radiation protection spacesuit (United States)

    Vuolo, M.; Baiocco, G.; Barbieri, S.; Bocchini, L.; Giraudo, M.; Gheysens, T.; Lobascio, C.; Ottolenghi, A.


    We present a design study for a wearable radiation-shielding spacesuit, designed to protect astronauts' most radiosensitive organs. The suit could be used in an emergency, to perform necessary interventions outside a radiation shelter in the space habitat in case of a Solar Proton Event (SPE). A wearable shielding system of the kind we propose has the potential to prevent the onset of acute radiation effects in this scenario. In this work, selection of materials for the spacesuit elements is performed based on the results of dedicated GRAS/Geant4 1-dimensional Monte Carlo simulations, and after a trade-off analysis between shielding performance and availability of resources in the space habitat. Water is the first choice material, but also organic compounds compatible with a human space habitat are considered (such as fatty acids, gels and liquid organic wastes). Different designs and material combinations are proposed for the spacesuits. To quantify shielding performance we use GRAS/Geant4 simulations of an anthropomorphic phantom in an average SPE environment, with and without the spacesuit, and we compare results for the dose to Blood Forming Organs (BFO) in Gy-Eq, i.e. physical absorbed dose multiplied by the proton Relative Biological Effectiveness (RBE) for non-cancer effects. In case of SPE occurrence for Intra-Vehicular Activities (IVA) outside a radiation shelter, dose reductions to BFO in the range of 44-57% are demonstrated to be achievable with the spacesuit designs made only of water elements, or of multi-layer protection elements (with a thin layer of a high density material covering the water filled volume). Suit elements have a thickness in the range 2-6 cm and the total mass for the garment sums up to 35-43 kg depending on model and material combination. Dose reduction is converted into time gain, i.e. the increase of time interval between the occurrence of a SPE and the moment the dose limit to the BFO for acute effects is reached. Wearing a

  8. Imaging analyses of odontogenic infection involving the maxillofacial fascial spaces, with special emphasis on the parapharyngeal space

    Energy Technology Data Exchange (ETDEWEB)

    Ariji, Yoshiko; Gotoh, Masakazu; Izumi, Masahiro; Naitoh, Munetaka; Kurita, Kenichi; Natsume, Nagato; Ariji, Eiichiro [Aichi-Gakuin Univ., Nisshin (Japan). School of Dentistry


    The purpose of this study was to investigate odontogenic infection pathways into the maxillofacial fascial spaces, especially into the parapharyngeal space, in relation to causal tooth and clinical symptoms. CT and MR images were retrospectively investigated in 47 patients with spread of odontogenic infection into the maxillofacial spaces. The involvement of spaces was evaluated based on lateral asymmetry of their shapes and density on CT images or intensity on MR images. Involvement on images was observed in 70%, 49%, and 30% of the submandibular, the masticator, and the parapharyngeal spaces, respectively. Patients with submandibular space involvement often had spontaneous pain. Of 14 patients with parapharyngeal space involvement, 8 patients showed dysphagia and/or fever, and 13 patients showed involvement of the mandibular molar as a cause of infection. All of these 14 patients also had submandibular space involvement, while only 7 patients (50%) showed changes in the medial pterygoid muscle. The fat layer between the medial pterygoid muscle and parapharyngeal space was maintained in 11 of 14 (79%) patients with parapharyngeal involvement. CT and MR images clearly demonstrated the spread of odontogenic infection into the maxillofacial spaces. Involvement of the parapharyngeal space was mostly caused by infection originating in the mandibular molar, and was considered to be secondary spread from the submandibular space and/or medial pterygoid muscle. (author)

  9. Feasibility of an image planning system for kilovoltage image-guided radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Thapa, Bishnu B.; Molloy, Janelle A. [Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky 40536-0293 (United States)


    Purpose: Image guidance has become a standard of care for many treatment scenarios in radiation therapy. This is most typically accomplished by use of kV x-ray devices mounted onto the linear accelerator (Linac) gantry that yield planar, fluoroscopic, and cone-beam computed tomography (CBCT) images. Image acquisition parameters are chosen via preset techniques that rely on broad categorizations in patient anatomy and imaging goal. However, the optimal imaging technique results in detectability of the features of interest while exposing the patient to minimum dose. Herein, the authors present an investigation into the feasibility of developing an image planning system (IPS) for radiotherapy.Methods: In this first phase, the authors focused on developing an algorithm to predict tissue contrast produced by a common radiotherapy planar imaging chain. Input parameters include a CT dataset and simulated planar imaging technique settings that include kV and mAs. Energy-specific attenuation through each voxel of the CT dataset was calculated in the algorithm to derive a net transmitted intensity. The response of the flat panel detector was integrated into the image simulation algorithm. Verification was conducted by comparing simulated and measured images using four phantoms. Comparisons were made in both high and low contrast settings, as well as changes in the geometric appearance due to image saturation. Results: The authors studied a lung nodule test object to assess the planning system's ability to predict object contrast and detectability. Verification demonstrated that the slope of the pixel intensities is similar, the presence of the nodule is evident, and image saturation at high mAs values is evident in both images. The appearance of the lung nodule is a function of the image detector saturation. The authors assessed the dimensions of the lung nodule in measured and simulated images. Good quantitative agreement affirmed the algorithm's predictive

  10. Comparison of image quality and radiation exposure from C-arm fluoroscopes when used for imaging the spine. (United States)

    Prasarn, Mark L; Coyne, Ellen; Schreck, Michael; Rodgers, Jamie D; Rechtine, Glenn R


    Cadaveric imaging study. We sought to compare the fluoroscopic images produced by 4 different fluoroscopes for image quality and radiation exposure when used for imaging the spine. There are no previous published studies comparing mobile C-arm machines commonly used in clinical practice for imaging the spine. Anterior-posterior and lateral images of the cervical, thoracic, and lumbar spine were obtained from a cadaver placed supine on a radiolucent table. The fluoroscopy units used for the study included (1) GE OEC 9900 Elite (2010 model; General Electric Healthcare, Waukesha, WI), (2) Philips BV Pulsera (2009 model; Philips Healthcare, Andover, MA), (3) Philips BV Pulsera (2010 model; Philips Healthcare, Andover, MA), and (4) Siemens Arcadis Avantic (2010 model; Siemens Medical Solutions, Malvern, PA). The images were then downloaded, placed into a randomizer program, and evaluated by a group of spine surgeons and neuroradiologists independently. The reviewers, who were blinded to the fluoroscope the images were from, ranked them from best to worst using a numeric system. In addition, the images were rated according to a quality scale from 1 to 5, with 1 representing the best image quality. The radiation exposure level for the fluoroscopy units was also compared and was based on energy emission. According to the mean values for rank, the following order of best to worst was observed: (1) GE OEC > (2) Philips 2010 > (3) Philips 2009 > (4) Siemans. The exact same order was found when examining the image quality ratings. When comparing the radiation exposure level difference, it was observed that the OEC was the lowest, and there was a minimum 30% decrease in energy emission from the OEC versus the other C-arms studied. This is the first time that the spine image quality and radiation exposure of commonly used C-arm machines have been compared. The OEC was ranked the best, produced the best quality images, and had the least amount of radiation.

  11. Space Radar Image of Jerusalem and the Dead Sea (United States)


    This space radar image shows the area surrounding the Dead Sea along the West Bank between Israel and Jordan. This region is of major cultural and historical importance to millions of Muslims, Jews and Christians who consider it the Holy Land. The yellow area at the top of the image is the city of Jericho. A portion of the Dead Sea is shown as the large black area at the top right side of the image. The Jordan River is the white line at the top of the image which flows into the Dead Sea. Jerusalem, which lies in the Judaean Hill Country, is the bright, yellowish area shown along the left center of the image. Just below and to the right of Jerusalem is the town of Bethlehem. The city of Hebron is the white, yellowish area near the bottom of the image. The area around Jerusalem has a history of more than 2,000 years of settlement and scientists are hoping to use these data to unveil more about this region's past. The Jordan River Valley is part of an active fault and rift system that extends from southern Turkey and connects with the east African rift zone. This fault system has produced major earthquakes throughout history and some scientists theorize that an earthquake may have caused the fall of Jericho's walls. The Dead Sea basin is formed by active earthquake faulting and contains the lowest place on the Earth's surface at about 400 meters (1,300 feet) below sea level. It was in caves along the northern shore of the Dead Sea that the Dead Sea Scrolls were found in 1947. The blue and green areas are generally regions of undeveloped hills and the dark green areas are the smooth lowlands of the Jordan River valley. This image is 73 kilometers by 45 kilometers (45 miles by 28 miles) and is centered at 31.7 degrees north latitude, 35.4 degrees east longitude. North is toward the upper left. The colors are assigned to different radar frequencies and polarizations as follows: red is L-band, horizontally transmitted and vertically received; green is L-band, horizontally

  12. Concomitant Imaging Dose and Cancer Risk in Image Guided Thoracic Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yibao; Wu, Hao [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital & Institute, Beijing (China); Chen, Zhe [Department of Therapeutic Radiology, Yale University, New Haven, Connecticut (United States); Knisely, Jonathan P.S. [Department of Radiation Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, New York (United States); Nath, Ravinder [Department of Therapeutic Radiology, Yale University, New Haven, Connecticut (United States); Feng, Zhongsu [Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiotherapy, Peking University Cancer Hospital & Institute, Beijing (China); Bao, Shanglian [Beijing Key Laboratory of Medical Physics and Engineering, Peking University, Beijing (China); Deng, Jun, E-mail: [Department of Therapeutic Radiology, Yale University, New Haven, Connecticut (United States)


    Purpose: Kilovoltage cone beam computed tomography (CT) (kVCBCT) imaging guidance improves the accuracy of radiation therapy but imposes an extra radiation dose to cancer patients. This study aimed to investigate concomitant imaging dose and associated cancer risk in image guided thoracic radiation therapy. Methods and Materials: The planning CT images and structure sets of 72 patients were converted to CT phantoms whose chest circumferences (C{sub chest}) were calculated retrospectively. A low-dose thorax protocol on a Varian kVCBCT scanner was simulated by a validated Monte Carlo code. Computed doses to organs and cardiac substructures (for 5 selected patients of various dimensions) were regressed as empirical functions of C{sub chest}, and associated cancer risk was calculated using the published models. The exposures to nonthoracic organs in children were also investigated. Results: The structural mean doses decreased monotonically with increasing C{sub chest}. For all 72 patients, the median doses to the heart, spinal cord, breasts, lungs, and involved chest were 1.68, 1.33, 1.64, 1.62, and 1.58 cGy/scan, respectively. Nonthoracic organs in children received 0.6 to 2.8 cGy/scan if they were directly irradiated. The mean doses to the descending aorta (1.43 ± 0.68 cGy), left atrium (1.55 ± 0.75 cGy), left ventricle (1.68 ± 0.81 cGy), and right ventricle (1.85 ± 0.84 cGy) were significantly different (P<.05) from the heart mean dose (1.73 ± 0.82 cGy). The blade shielding alleviated the exposure to nonthoracic organs in children by an order of magnitude. Conclusions: As functions of patient size, a series of models for personalized estimation of kVCBCT doses to thoracic organs and cardiac substructures have been proposed. Pediatric patients received much higher doses than did the adults, and some nonthoracic organs could be irradiated unexpectedly by the default scanning protocol. Increased cancer risks and disease adverse events in the

  13. Space Radar Image of Kilauea, Hawaii in 3-D (United States)


    This is a three-dimensional perspective view of a false-color image of the eastern part of the Big Island of Hawaii. It was produced using all three radar frequencies -- X-band, C-band and L-band -- from the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) flying on the space shuttle Endeavour, overlaid on a U.S. Geological Survey digital elevation map. Visible in the center of the image in blue are the summit crater (Kilauea Caldera) which contains the smaller Halemaumau Crater, and the line of collapse craters below them that form the Chain of Craters Road. The image was acquired on April 12, 1994 during orbit 52 of the space shuttle. The area shown is approximately 34 by 57 kilometers (21 by 35 miles) with the top of the image pointing toward northwest. The image is centered at about 155.25 degrees west longitude and 19.5 degrees north latitude. The false colors are created by displaying three radar channels of different frequency. Red areas correspond to high backscatter at L-HV polarization, while green areas exhibit high backscatter at C-HV polarization. Finally, blue shows high return at X-VV polarization. Using this color scheme, the rain forest appears bright on the image, while the green areas correspond to lower vegetation. The lava flows have different colors depending on their types and are easily recognizable due to their shapes. The flows at the top of the image originated from the Mauna Loa volcano. Kilauea volcano has been almost continuously active for more than the last 11 years. Field teams that were on the ground specifically to support these radar observations report that there was vigorous surface activity about 400 meters (one-quartermile) inland from the coast. A moving lava flow about 200 meters (650 feet) in length was observed at the time of the shuttle overflight, raising the possibility that subsequent images taken during this mission will show changes in the landscape. Currently, most of the lava that is

  14. Atmospheric measurements by Medipix-2 and Timepix Ionizing Radiation Imaging Detectors on BEXUS stratospheric balloon campaigns (United States)

    Urbar, Jaroslav; Scheirich, Jan; Jakubek, Jan


    Results of the first two experiments using semiconductor pixel detectors of the Medipix family for cosmic ray imaging in the stratospheric environment are presented. The original detecting device was based on the hybrid pixel detectors of Medipix-2 and Timepix developed at CERN with USB interface developed at Institute of Experimental and Applied Physics of Czech Technical University in Prague. The detectors were used in tracking mode allowing them to operate as an "active nuclear emulsion". The actual flight time of BEXUS7 with Medipix-2 on 8th October 2008 was over 4 hours, with 2 hours at stable floating altitude of 26km. BEXUS9 measurements of similar duration by Timepix, Medipix-2 and ST-6 Geiger telescope instruments took place in arctic atmosphere below 24km altitude on 11th October 2009. This balloon platform is quite ideal for such in-situ measurements. Not only because of the high altitudes reached, but also due to its slow ascent velocity for statistically relevant sampling of the ambient environment for improving cosmic ray induced ionisation rate model inputs. The flight opportunity for BEXUS student projects was provided by Education department of the European Space Agency (ESA) and Eurolaunch - Collaboration of Swedish National Space Board (SNSB) and German Space Agency (DLR). The scientific goal was to check energetic particle type altitudinal dependencies, also testing proper detector calibration by detecting fluxes of ionizing radiation, while evaluating instrumentation endurance and performance.

  15. Astronomers Make First Images With Space Radio Telescope (United States)


    Marking an important new milestone in radio astronomy history, scientists at the National Radio Astronomy Observatory (NRAO) in Socorro, New Mexico, have made the first images using a radio telescope antenna in space. The images, more than a million times more detailed than those produced by the human eye, used the new Japanese HALCA satellite, working in conjunction with the National Science Foundation's (NSF) Very Long Baseline Array (VLBA) and Very Large Array (VLA) ground-based radio telescopes. The landmark images are the result of a long-term NRAO effort supported by the National Aeronautics and Space Administration (NASA). "This success means that our ability to make detailed radio images of objects in the universe is no longer limited by the size of the Earth," said NRAO Director Paul Vanden Bout. "Astronomy's vision has just become much sharper." HALCA, launched on Feb. 11 by Japan's Institute of Space and Astronautical Science (ISAS), is the first satellite designed for radio astronomy imaging. It is part of an international collaboration led by ISAS and backed by NRAO; Japan's National Astronomical Observatory; NASA's Jet Propulsion Laboratory (JPL); the Canadian Space Agency; the Australia Telescope National Facility; the European VLBI Network and the Joint Institute for Very Long Baseline Interferometry in Europe. On May 22, HALCA observed a distant active galaxy called PKS 1519-273, while the VLBA and VLA also observed it. Data from the satellite was received by a tracking station at the NRAO facility in Green Bank, West Virginia. Tape-recorded data from the satellite and from the radio telescopes on the ground were sent to NRAO's Array Operations Center (AOC) in Socorro, NM. In Socorro, astronomers and computer scientists used a special-purpose computer to digitally combine the signals from the satellite and the ground telescopes to make them all work together as a single, giant radio telescope. This dedicated machine, the VLBA Correlator, built as

  16. Influence of crystal shapes on radiative fluxes in visible wavelength: ice crystals randomly oriented in space

    Directory of Open Access Journals (Sweden)

    P. Chervet


    Full Text Available Radiative properties of cirrus clouds are one of the major unsolved problems in climate studies and global radiation budget. These clouds are generally composed of various ice-crystal shapes, so we tried to evaluate effects of the ice-crystal shape on radiative fluxes. We calculated radiative fluxes of cirrus clouds with a constant geometrical depth, composed of ice crystals with different shapes (hexagonal columns, bullets, bullet-rosettes, sizes and various concentrations. We considered ice particles randomly oriented in space (3D case and their scattering phase functions were calculated by a ray-tracing method. We calculated radiative fluxes for cirrus layers for different microphysical characteristics by using a discrete-ordinate radiative code. Results showed that the foremost effect of the ice-crystal shape on radiative properties of cirrus clouds was that on the optical thickness, while the variation of the scattering phase function with the ice shape remained less than 3% for our computations. The ice-water content may be a better choice to parameterize the optical properties of cirrus, but the shape effect must be included.

  17. Experimental measurements of the radiation hazards associated with manned space flights. (United States)

    Clark, B C; Adams, D A


    Tissue-equivalent ionization chambers of special design have been flown on U.S. satellites to determine dose-rate levels in space. A chamber shielded by 4.7 g/cm2 measured doses from energetic protons in the inner Van Allen belt and bremsstrahlung radiation produced by relativistic electrons from the artificial radiation belt formed in July 1962. In November 1962, the maximum dose-rate in space for this shield was 30 rad/hr. Behind 0.4 g/cm2 shielding, the dose-rate peak was 20000 rad/hr. These doses have been determined to be due to artificial electrons in most regions of space, masking the dose arising from energetic protons.

  18. Developmental Research in Space: Predicting Adult Neurobehavioral Phenotypes via Metabolomic Imaging (United States)

    Schorn, Julia M.; Moyer, Eric L.; Lowe, M.; Morgan, Jonathan A.; Tulbert, Christina D.; Olson, John; Horita, David A.; Klevin, Gale A.; Ronca, April E.


    As human habitation and eventual colonization of space becomes an inevitable reality, there is a necessity to understand how organisms develop over the life span in the space environment. Microgravity, altered CO2, radiation and psychological stress are some of the key factors that could affect mammalian reproduction and development in space, however there is a paucity of information on this topic. Here we combine early (neonatal) in vivo spectroscopic imaging with an adult emotionality assay following a common obstetric complication (prenatal asphyxia) likely to occur during gestation in space. The neural metabolome is sensitive to alteration by degenerative changes and developmental disorders, thus we hypothesized that that early neonatal neurometabolite profiles can predict adult response to novelty. Late gestation fetal rats were exposed to moderate asphyxia by occluding the blood supply feeding one of the rats pair uterine horns for 15min. Blood supply to the opposite horn was not occluded (within-litter cesarean control). Further comparisons were made with vaginal (natural) birth controls. In one-week old neonates, we measured neurometabolites in three brain areas (i.e., striatum, prefrontal cortex, and hippocampus). Adult perinatally-asphyxiated offspring exhibited greater anxiety-like behavioral phenotypes (as measured the composite neurobehavioral assay involving open field activity, responses to novel object, quantification of fecal droppings, and resident-intruder tests of social behavior). Further, early neurometabolite profiles predicted adult responses. Non-invasive MRS screening of mammalian offspring is likely to advance ground-based space analogue studies informing mammalian reproduction in space, and achieving high-priority multigenerational research that will enable studies of the first truly space-developed mammals.

  19. Contribution of modern medical imaging technology to radiation health effects in exposed populations

    Energy Technology Data Exchange (ETDEWEB)

    Fabrikant, J.I,


    The introduction of technically-advanced imaging systems in medicine carries with it potential health hazards, particularly from ionizing and nonionizing radiation exposure of human populations. This paper will discuss what we know and what we do not know about the health effects of low-level radiation, how the risks of radiation-induced health effects may be estimated, the sources of the scientific data, the dose-response models used, the uncertainties which limit precision of estimation of excess health risks from low-level radiation, and what the implications might be for radiation protection in medicine and public health policy.

  20. Ionizing radiation risks to Satellite Power Systems (SPS) workers in space

    Energy Technology Data Exchange (ETDEWEB)


    A reference Satellite Power System (SPS) has been designed by NASA and its contractors for the purposes of evaluating the concept and carrying out assessments of the various consequences of development, including those on the health of the space workers. The Department of Energy has responsibility for directing various assessments. Present planning calls for the SPS workers to move from Earth to a low earth orbit (LEO) at an altitude of 500 kilometers; to travel by a transfer ellipse (TE) trajectory to a geosynchronous orbit (GEO) at an altitude of 36,000 kilometers; and to remain in GEO orbit for about 90 percent of the total time aloft. The radiation risks to the health of workers who will construct and maintain solar power satellites in the space environment are studied. The charge to the committee was: (a) to evaluate the radiation environment estimated for the Reference System which could represent a hazard; (b) to assess the possible somatic and genetic radiation hazards; and (c) to estimate the risks to the health of SPS workers due to space radiation exposure, and to make recommendations based on these conclusions. Details are presented. (WHK)

  1. Development of a space radiation Monte Carlo computer simulation based on the FLUKA and ROOT codes

    CERN Document Server

    Pinsky, L; Ferrari, A; Sala, P; Carminati, F; Brun, R


    This NASA funded project is proceeding to develop a Monte Carlo-based computer simulation of the radiation environment in space. With actual funding only initially in place at the end of May 2000, the study is still in the early stage of development. The general tasks have been identified and personnel have been selected. The code to be assembled will be based upon two major existing software packages. The radiation transport simulation will be accomplished by updating the FLUKA Monte Carlo program, and the user interface will employ the ROOT software being developed at CERN. The end-product will be a Monte Carlo-based code which will complement the existing analytic codes such as BRYNTRN/HZETRN presently used by NASA to evaluate the effects of radiation shielding in space. The planned code will possess the ability to evaluate the radiation environment for spacecraft and habitats in Earth orbit, in interplanetary space, on the lunar surface, or on a planetary surface such as Mars. Furthermore, it will be usef...

  2. Imaging Changes in Pediatric Intracranial Ependymoma Patients Treated With Proton Beam Radiation Therapy Compared to Intensity Modulated Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Gunther, Jillian R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Sato, Mariko; Chintagumpala, Murali [Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children' s Cancer Center, Houston, Texas (United States); Ketonen, Leena [Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Jones, Jeremy Y. [Department of Pediatric Radiology, Texas Children' s Hospital, Houston, Texas (United States); Allen, Pamela K. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Paulino, Arnold C. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children' s Cancer Center, Houston, Texas (United States); Okcu, M. Fatih; Su, Jack M. [Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Texas Children' s Cancer Center, Houston, Texas (United States); Weinberg, Jeffrey [Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Boehling, Nicholas S. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Khatua, Soumen [Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Adesina, Adekunle [Department of Pathology, Baylor College of Medicine, Texas Children' s Hospital, Houston, Texas (United States); Dauser, Robert; Whitehead, William E. [Department of Neurosurgery, Texas Children' s Hospital, Houston, Texas (United States); Mahajan, Anita, E-mail: [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)


    Purpose: The clinical significance of magnetic resonance imaging (MRI) changes after radiation therapy (RT) in children with ependymoma is not well defined. We compared imaging changes following proton beam radiation therapy (PBRT) to those after photon-based intensity modulated RT (IMRT). Methods and Materials: Seventy-two patients with nonmetastatic intracranial ependymoma who received postoperative RT (37 PBRT, 35 IMRT) were analyzed retrospectively. MRI images were reviewed by 2 neuroradiologists. Results: Sixteen PBRT patients (43%) developed postradiation MRI changes at 3.8 months (median) with resolution by 6.1 months. Six IMRT patients (17%) developed changes at 5.3 months (median) with 8.3 months to resolution. Mean age at radiation was 4.4 and 6.9 years for PBRT and IMRT, respectively (P=.06). Age at diagnosis (>3 years) and time of radiation (≥3 years) was associated with fewer imaging changes on univariate analysis (odds ratio [OR]: 0.35, P=.048; OR: 0.36, P=.05). PBRT (compared to IMRT) was associated with more frequent imaging changes, both on univariate (OR: 3.68, P=.019) and multivariate (OR: 3.89, P=.024) analyses. Seven (3 IMRT, 4 PBRT) of 22 patients with changes had symptoms requiring intervention. Most patients were treated with steroids; some PBRT patients also received bevacizumab and hyperbaric oxygen therapy. None of the IMRT patients had lasting deficits, but 2 patients died from recurrent disease. Three PBRT patients had persistent neurological deficits, and 1 child died secondarily to complications from radiation necrosis. Conclusions: Postradiation MRI changes are more common with PBRT and in patients less than 3 years of age at diagnosis and treatment. It is difficult to predict causes for development of imaging changes that progress to clinical significance. These changes are usually self-limiting, but some require medical intervention, especially those involving the brainstem.

  3. Radiation Engineering Analysis of Shielding Materials to Assess Their Ability to Protect Astronauts in Deep Space From Energetic Particle Radiation (United States)

    Singleterry, R. C.


    An analysis is performed on four typical materials (aluminum, liquid hydrogen, polyethylene, and water) to assess their impact on the length of time an astronaut can stay in deep space and not exceed a design basis radiation exposure of 150 mSv. A large number of heavy lift launches of pure shielding mass are needed to enable long duration, deep space missions to keep astronauts at or below the exposure value with shielding provided by the vehicle. Therefore, vehicle mass using the assumptions in the paper cannot be the sole shielding mechanism for long duration, deep space missions. As an example, to enable the Mars Design Reference Mission 5.0 with a 400 day transit to and from Mars, not including the 500 day stay on the surface, a minimum of 24 heavy lift launches of polyethylene at 89,375 lbm (40.54 tonnes) each are needed for the 1977 galactic cosmic ray environment. With the assumptions used in this paper, a single heavy lift launch of water or polyethylene can protect astronauts for a 130 day mission before exceeding the exposure value. Liquid hydrogen can only protect the astronauts for 160 days. Even a single launch of pure shielding material cannot protect an astronaut in deep space for more than 180 days using the assumptions adopted in the analysis. It is shown that liquid hydrogen is not the best shielding material for the same mass as polyethylene for missions that last longer than 225 days.

  4. Imaging Primary Mouse Sarcomas After Radiation Therapy Using Cathepsin-Activatable Fluorescent Imaging Agents

    Energy Technology Data Exchange (ETDEWEB)

    Cuneo, Kyle C. [Department of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina (United States); Mito, Jeffrey K.; Javid, Melodi P. [Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina (United States); Ferrer, Jorge M. [Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts (United States); Kim, Yongbaek [Department of Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul (Korea, Republic of); Lee, W. David [The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts (United States); Bawendi, Moungi G. [Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts (United States); Brigman, Brian E. [Department of Orthopedic Surgery, Duke University School of Medicine, Durham, North Carolina (United States); Kirsch, David G., E-mail: [Department of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina (United States); Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina (United States)


    Purpose: Cathepsin-activated fluorescent probes can detect tumors in mice and in canine patients. We previously showed that these probes can detect microscopic residual sarcoma in the tumor bed of mice during gross total resection. Many patients with soft tissue sarcoma (STS) and other tumors undergo radiation therapy (RT) before surgery. This study assesses the effect of RT on the ability of cathepsin-activated probes to differentiate between normal and cancerous tissue. Methods and Materials: A genetically engineered mouse model of STS was used to generate primary hind limb sarcomas that were treated with hypofractionated RT. Mice were injected intravenously with cathepsin-activated fluorescent probes, and various tissues, including the tumor, were imaged using a hand-held imaging device. Resected tumor and normal muscle samples were harvested to assess cathepsin expression by Western blot. Uptake of activated probe was analyzed by flow cytometry and confocal microscopy. Parallel in vitro studies using mouse sarcoma cells were performed. Results: RT of primary STS in mice and mouse sarcoma cell lines caused no change in probe activation or cathepsin protease expression. Increasing radiation dose resulted in an upward trend in probe activation. Flow cytometry and immunofluorescence showed that a substantial proportion of probe-labeled cells were CD11b-positive tumor-associated immune cells. Conclusions: In this primary murine model of STS, RT did not affect the ability of cathepsin-activated probes to differentiate between tumor and normal muscle. Cathepsin-activated probes labeled tumor cells and tumor-associated macrophages. Our results suggest that it would be feasible to include patients who have received preoperative RT in clinical studies evaluating cathepsin-activated imaging probes.

  5. Reducing Radiation Dose Without Compromising Image Quality in Preoperative Perforator Flap Imaging With CTA Using ASIR Technology (United States)

    Niumsawatt, Vachara; Debrotwir, Andrew N.; Rozen, Warren Matthew


    Computed tomographic angiography (CTA) has become a mainstay in preoperative perforator flap planning in the modern era of reconstructive surgery. However, the increased use of CTA does raise the concern of radiation exposure to patients. Several techniques have been developed to decrease radiation dosage without compromising image quality, with varying results. The most recent advance is in the improvement of image reconstruction using an adaptive statistical iterative reconstruction (ASIR) algorithm. We sought to evaluate the image quality of ASIR in preoperative deep inferior epigastric perforator (DIEP) flap surgery, through a direct comparison with conventional filtered back projection (FBP) images. A prospective review of 60 consecutive ASIR and 60 consecutive FBP CTA images using similar protocol (except for radiation dosage) was undertaken, analyzed by 2 independent reviewers. In both groups, we were able to accurately identify axial arteries and their perforators. Subjective analysis of image quality demonstrated no statistically significant difference between techniques. ASIR can thus be used for preoperative imaging with similar image quality to FBP, but with a 60% reduction in radiation delivery to patients. PMID:25058789

  6. NASA Models of Space Radiation Induced Cancer, Circulatory Disease, and Central Nervous System Effects (United States)

    Cucinotta, Francis A.; Chappell, Lori J.; Kim, Myung-Hee Y.


    The risks of late effects from galactic cosmic rays (GCR) and solar particle events (SPE) are potentially a limitation to long-term space travel. The late effects of highest concern have significant lethality including cancer, effects to the central nervous system (CNS), and circulatory diseases (CD). For cancer and CD the use of age and gender specific models with uncertainty assessments based on human epidemiology data for low LET radiation combined with relative biological effectiveness factors (RBEs) and dose- and dose-rate reduction effectiveness factors (DDREF) to extrapolate these results to space radiation exposures is considered the current "state-of-the-art". The revised NASA Space Risk Model (NSRM-2014) is based on recent radio-epidemiology data for cancer and CD, however a key feature of the NSRM-2014 is the formulation of particle fluence and track structure based radiation quality factors for solid cancer and leukemia risk estimates, which are distinct from the ICRP quality factors, and shown to lead to smaller uncertainties in risk estimates. Many persons exposed to radiation on earth as well as astronauts are life-time never-smokers, which is estimated to significantly modify radiation cancer and CD risk estimates. A key feature of the NASA radiation protection model is the classification of radiation workers by smoking history in setting dose limits. Possible qualitative differences between GCR and low LET radiation increase uncertainties and are not included in previous risk estimates. Two important qualitative differences are emerging from research studies. The first is the increased lethality of tumors observed in animal models compared to low LET radiation or background tumors. The second are Non- Targeted Effects (NTE), which include bystander effects and genomic instability, which has been observed in cell and animal models of cancer risks. NTE's could lead to significant changes in RBE and DDREF estimates for GCR particles, and the potential

  7. Poster - Thur Eve - 65: Optimization of an automatic image contouring system for radiation therapy. (United States)

    Hamilton, T; Nedialkov, N; Wierzbicki, M


    Intensity modulated radiation therapy (IMRT) is an advanced technique used to concentrate the prescribed dose in the tumour while minimizing exposure to healthy tissues. Success in IMRT is greatly dependent upon the localization of the target volume and normal tissue, thus accurate contouring is crucial. In this paper, we describe an automated atlas-based image contouring system and our approach for improving the system by performing a full-scale optimization of registration parameters using high-performance computing. To achieve this, we use manually pre-contoured CT images of ten head and neck patients. For any parameter set, each patient data is registered with the remaining patients. Accuracy of the resulting contours is determined automatically by comparing their overlap with manually defined targets using Dice's similarity coefficient (DSC). This allows us to compare all permutations of the image registration parameter sets and input data to investigate their impact on final contour accuracy. Investigating the parameter space required 27,000 image registrations and 216,000 DSC computations. To perform these registrations we introduced a large cluster of high-performance computers and developed a parallel testing harness. The metrics collected from the tests show a wide range of performance, indicating that parameter selection is crucial in our contouring system. By selecting an optimized parameter set, we increased the mean overlap of the automatically contoured regions of interest by 50% and reduced registration time by 50% compared to the original parameters. Our findings illustrate that full-scale optimization is an effective method for improving the performance of the automated image contouring system. © 2012 American Association of Physicists in Medicine.

  8. Quantification of the aerosol direct radiative effect from smoke over clouds using passive space-borne spectrometry (United States)

    de Graaf, M.; Stammes, P.; Tilstra, L. G.


    The solar radiative absorption by smoke layers above clouds is quantified, using the unique broad spectral range of the space-borne spectrometer Scanning Imaging Absorption Spectrometer for Atmospheric Chartography (SCIAMACHY) from the ultraviolet (UV) to the shortwave infrared (SWIR). Aerosol radiative effects in the UV are separated from cloud radiative effects in the shortwave infrared (SWIR). In the UV, aerosol absorption from smoke is strong, creating a strong signal in the measured reflectance. In the SWIR, absorbing and scattering effects from smoke are negligible, allowing the retrieval of cloud parameters from the measured spectrum using existing retrieval techniques. The spectral signature of the cloud can be modelled using a radiative transfer model (RTM) and the cloud parameters retrieved in the SWIR. In this way, the aerosol effects can be determined from the measured aerosol-polluted cloud shortwave spectrum and the modelled aerosol-unpolluted cloud shortwave spectrum. This can be used to derive the aerosol direct radiative effect (DRE) over marine clouds, independent of aerosol parameter retrievals, significantly improving the current accuracy of aerosol DRE estimates. Only cloud parameters are needed to model the aerosolunpolluted cloud reflectance, while the effects of the aerosol absorption are in the aerosol-polluted cloud reflectance measurements. In this paper we present a case study of the above method using SCIAMACHY data over the South Atlantic Ocean west of Africa on 13 August 2006, when a huge plume of smoke was present over persistent cloud fields. The aerosol DRE over clouds was as high as 128 ± 8 Wm-2 for this case, while the aerosol DRE over clouds averaged through August 2006 was found to be 23 ± 8 Wm-2 with a mean variation over the region in this month of 22 Wm-2.

  9. CT radiation dose and image quality optimization using a porcine model. (United States)

    Zarb, Francis; McEntee, Mark F; Rainford, Louise


    To evaluate potential radiation dose savings and resultant image quality effects with regard to optimization of commonly performed computed tomography (CT) studies derived from imaging a porcine (pig) model. Imaging protocols for 4 clinical CT suites were developed based on the lowest milliamperage and kilovoltage, the highest pitch that could be set from current imaging protocol parameters, or both. This occurred before significant changes in noise, contrast, and spatial resolution were measured objectively on images produced from a quality assurance CT phantom. The current and derived phantom protocols were then applied to scan a porcine model for head, abdomen, and chest CT studies. Further optimized protocols were developed based on the same methodology as in the phantom study. The optimization achieved with respect to radiation dose and image quality was evaluated following data collection of radiation dose recordings and image quality review. Relative visual grading analysis of image quality criteria adapted from the European guidelines on radiology quality criteria for CT were used for studies completed with both the phantom-based or porcine-derived imaging protocols. In 5 out of 16 experimental combinations, the current clinical protocol was maintained. In 2 instances, the phantom protocol reduced radiation dose by 19% to 38%. In the remaining 9 instances, the optimization based on the porcine model further reduced radiation dose by 17% to 38%. The porcine model closely reflects anatomical structures in humans, allowing the grading of anatomical criteria as part of image quality review without radiation risks to human subjects. This study demonstrates that using a porcine model to evaluate CT optimization resulted in more radiation dose reduction than when imaging protocols were tested solely on quality assurance phantoms.

  10. The Sun Radio Imaging Space Experiment (SunRISE) Mission (United States)

    Lazio, Joseph; Kasper, Justin; Maksimovic, Milan; Alibay, Farah; Amiri, Nikta; Bastian, Tim; Cohen, Christina; Landi, Enrico; Manchester, Ward; Reinard, Alysha; Schwadron, Nathan; Cecconi, Baptiste; Hallinan, Gregg; Hegedus, Alex; Krupar, Vratislav; Zaslavsky, Arnaud


    Radio emission from coronal mass ejections (CMEs) is a direct tracer of particle acceleration in the inner heliosphere and potential magnetic connections from the lower solar corona to the larger heliosphere. Energized electrons excite Langmuir waves, which then convert into intense radio emission at the local plasma frequency, with the most intense acceleration thought to occur within 20 RS. The radio emission from CMEs is quite strong such that only a relatively small number of antennas is required to detect and map it, but many aspects of this particle acceleration and transport remain poorly constrained. Ground-based arrays would be quite capable of tracking the radio emission associated with CMEs, but absorption by the Earth's ionosphere limits the frequency coverage of ground-based arrays (ν ≳ 15 MHz), which in turn limits the range of solar distances over which they can track the radio emission (≲ 3RS). The state-of-the-art for tracking such emission from space is defined by single antennas (Wind/WAVES, Stereo/SWAVES), in which the tracking is accomplished by assuming a frequency-to-density mapping; there has been some success in triangulating the emission between the spacecraft, but considerable uncertainties remain. We describe the Sun Radio Imaging Space Experiment (SunRISE) mission concept: A constellation of small spacecraft in a geostationary graveyard orbit designed to localize and track radio emissions in the inner heliosphere. Each spacecraft would carry a receiving system for observations below 25 MHz, and SunRISE would produce the first images of CMEs more than a few solar radii from the Sun. Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

  11. Image gently, step lightly: increasing radiation dose awareness in pediatric interventions through an international social marketing campaign. (United States)

    Sidhu, Manrita K; Goske, Marilyn J; Coley, Brian J; Connolly, Bairbre; Racadio, John; Yoshizumi, Terry T; Utley, Tara; Strauss, Keith J


    In the past several decades, advances in imaging and interventional techniques have been accompanied by an increase in medical radiation dose to the public. Radiation exposure is even more important in children, who are more sensitive to radiation and have a longer lifespan during which effects may manifest. To address radiation safety in pediatric computed tomography, in 2008 the Alliance for Radiation Safety in Pediatric Imaging launched an international social marketing campaign entitled Image Gently. This article describes the next phase of the Image Gently campaign, entitled Step Lightly, which focuses on radiation safety in pediatric interventional radiology.

  12. Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells (United States)

    Alhallak, Kinan; Jenkins, Samir V.; Lee, David E.; Greene, Nicholas P.; Quinn, Kyle P.; Griffin, Robert J.; Dings, Ruud P. M.; Rajaram, Narasimhan


    Radiation resistance remains a significant problem for cancer patients, especially due to the time required to definitively determine treatment outcome. For fractionated radiation therapy, nearly 7 to 8 weeks can elapse before a tumor is deemed to be radiation-resistant. We used the optical redox ratio of FAD/(FAD+NADH) to identify early metabolic changes in radiation-resistant lung cancer cells. These radiation-resistant human A549 lung cancer cells were developed by exposing the parental A549 cells to repeated doses of radiation (2 Gy). Although there were no significant differences in the optical redox ratio between the parental and resistant cell lines prior to radiation, there was a significant decrease in the optical redox ratio of the radiation-resistant cells 24 h after a single radiation exposure (p=0.01). This change in the redox ratio was indicative of increased catabolism of glucose in the resistant cells after radiation and was associated with significantly greater protein content of hypoxia-inducible factor 1 (HIF-1α), a key promoter of glycolytic metabolism. Our results demonstrate that the optical redox ratio could provide a rapid method of determining radiation resistance status based on early metabolic changes in cancer cells.

  13. Grazing-incidence telescope-spectrograph for space solar-imaging spectroscopy. (United States)

    Poletto, L; Tondello, G


    The design of a stigmatic grazing-incidence instrument for space applications to solar-imaging spectroscopy is presented. It consists of a double telescope and a spectrograph: Telescope I consists of a single cylindrical mirror with parabolic section, focusing the radiation on the entrance slit of the spectrograph in the spectral dispersion plane; telescope II consists of two cylindrical mirrors with aspherical section in a Wolter configuration, focusing the radiation on the spectrograph focal plane in the direction perpendicular to the spectral dispersion plane. The spectrograph consists of a grazing-incidence spherical variable-line-spaced grating with flat-field properties. Telescope II is crossed with respect to the grating and telescope I; i.e., it is mounted with its tangential planes coincident with the grating equatorial plane. The spectrum is acquired by a detector mounted at near-normal incidence with respect to the direction of the exit beam. The spectral resolution is also preserved for off-axis angles. The effective collecting area of the instrument can be preserved by adoption of a nested configuration for telescope II without degradation of the spectral resolution.

  14. Implementing Badhwar-O'Neill Galactic Cosmic Ray Model for the Analysis of Space Radiation Exposure (United States)

    Kim, Myung-Hee Y.; O'Neill, Patrick M.; Slaba, Tony C.


    For the analysis of radiation risks to astronauts and planning exploratory space missions, accurate energy spectrum of galactic cosmic radiation (GCR) is necessary. Characterization of the ionizing radiation environment is challenging because the interplanetary plasma and radiation fields are modulated by solar disturbances and the radiation doses received by astronauts in interplanetary space are likewise influenced. A model of the Badhwar-O'Neill 2011 (BO11) GCR environment, which is represented by GCR deceleration potential theta, has been derived by utilizing all of the GCR measurements from balloons, satellites, and the newer NASA Advanced Composition Explorer (ACE). In the BO11 model, the solar modulation level is derived from the mean international sunspot numbers with time-delay, which has been calibrated with actual flight instrument measurements to produce better GCR flux data fit during solar minima. GCR fluxes provided by the BO11 model were compared with various spacecraft measurements at 1 AU, and further comparisons were made for the tissue equivalent proportional counters measurements at low Earth orbits using the high-charge and energy transport (HZETRN) code and various GCR models. For the comparison of the absorbed dose and dose equivalent calculations with the measurements by Radiation Assessment Detector (RAD) at Gale crater on Mars, the intensities and energies of GCR entering the heliosphere were calculated by using the BO11 model, which accounts for time-dependent attenuation of the local interstellar spectrum of each element. The BO11 model, which has emphasized for the last 24 solar minima, showed in relatively good agreement with the RAD data for the first 200 sols, but it was resulted in to be less well during near the solar maximum of solar cycle 24 due to subtleties in the changing heliospheric conditions. By performing the error analysis of the BO11 model and the optimization in reducing overall uncertainty, the resultant BO13 model

  15. Task-based image quality assessment in radiation therapy: initial characterization and demonstration with CT simulation images (United States)

    Dolly, Steven R.; Anastasio, Mark A.; Yu, Lifeng; Li, Hua


    In current radiation therapy practice, image quality is still assessed subjectively or by utilizing physically-based metrics. Recently, a methodology for objective task-based image quality (IQ) assessment in radiation therapy was proposed by Barrett et al.1 In this work, we present a comprehensive implementation and evaluation of this new IQ assessment methodology. A modular simulation framework was designed to perform an automated, computer-simulated end-to-end radiation therapy treatment. A fully simulated framework was created that utilizes new learning-based stochastic object models (SOM) to obtain known organ boundaries, generates a set of images directly from the numerical phantoms created with the SOM, and automates the image segmentation and treatment planning steps of a radiation therapy work ow. By use of this computational framework, therapeutic operating characteristic (TOC) curves can be computed and the area under the TOC curve (AUTOC) can be employed as a figure-of-merit to guide optimization of different components of the treatment planning process. The developed computational framework is employed to optimize X-ray CT pre-treatment imaging. We demonstrate that use of the radiation therapy-based-based IQ measures lead to different imaging parameters than obtained by use of physical-based measures.

  16. Removing Noises Induced by Gamma Radiation in Cerenkov Luminescence Imaging Using a Temporal Median Filter

    Directory of Open Access Journals (Sweden)

    Xu Cao


    Full Text Available Cerenkov luminescence imaging (CLI can provide information of medical radionuclides used in nuclear imaging based on Cerenkov radiation, which makes it possible for optical means to image clinical radionuclide labeled probes. However, the exceptionally weak Cerenkov luminescence (CL from Cerenkov radiation is susceptible to lots of impulse noises introduced by high energy gamma rays generating from the decays of radionuclides. In this work, a temporal median filter is proposed to remove this kind of impulse noises. Unlike traditional CLI collecting a single CL image with long exposure time and smoothing it using median filter, the proposed method captures a temporal sequence of CL images with shorter exposure time and employs a temporal median filter to smooth a temporal sequence of pixels. Results of in vivo experiments demonstrated that the proposed temporal median method can effectively remove random pulse noises induced by gamma radiation and achieve a robust CLI image.

  17. Detection of space radiation-induced double strand breaks as a track in cell nucleus

    Energy Technology Data Exchange (ETDEWEB)

    Ohnishi, Takeo, E-mail: [Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Takahashi, Akihisa [Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Nagamatsu, Aiko; Omori, Katsunori [Japan Aerospace Exploration Agency, 2-1-1 Sengen, Tsukuba-shi, Ibaraki 305-8505 (Japan); Suzuki, Hiromi; Shimazu, Toru [Japan Space Forum, 2-2-1 Otemachi, Chiyoda-ku, Tokyo 104-0004 (Japan); Ishioka, Noriaki [Japan Aerospace Exploration Agency, 2-1-1 Sengen, Tsukuba-shi, Ibaraki 305-8505 (Japan)


    To identify DNA damage induced by space radiations such as the high linear energy transfer (LET) particles, phospho-H2AX ({gamma}H2AX) foci formation was analyzed in human cells frozen in an International Space Station freezer for 133 days. After recovering the frozen sample to the earth, the cells were cultured for 30 min, and then fixed. Here we show a track of {gamma}H2AX positive foci in them by immuno-cytochemical methods. It is suggested that space radiations, especially high LET particles, induced DSBs as a track. From the formation of the tracks in nuclei, exposure dose rate was calculated to be 0.7 mSv per day as relatively high-energy space radiations of Fe-ions (500 MeV/u, 200 keV/{mu}m). From the physical dosimetry with CR-39 plastic nuclear track detectors and thermo-luminescent dosimeters, dose rate was 0.5 mSv per day. These values the exposed dose rate were similar between biological and physical dosimetries.

  18. Detection of space radiation-induced double strand breaks as a track in cell nucleus. (United States)

    Ohnishi, Takeo; Takahashi, Akihisa; Nagamatsu, Aiko; Omori, Katsunori; Suzuki, Hiromi; Shimazu, Toru; Ishioka, Noriaki


    To identify DNA damage induced by space radiations such as the high linear energy transfer (LET) particles, phospho-H2AX (gammaH2AX) foci formation was analyzed in human cells frozen in an International Space Station freezer for 133days. After recovering the frozen sample to the earth, the cells were cultured for 30 min, and then fixed. Here we show a track of gammaH2AX positive foci in them by immuno-cytochemical methods. It is suggested that space radiations, especially high LET particles, induced DSBs as a track. From the formation of the tracks in nuclei, exposure dose rate was calculated to be 0.7 mSv per day as relatively high-energy space radiations of Fe-ions (500 MeV/u, 200 keV/microm). From the physical dosimetry with CR-39 plastic nuclear track detectors and thermo-luminescent dosimeters, dose rate was 0.5 mSv per day. These values the exposed dose rate were similar between biological and physical dosimetries.

  19. Multi-mission modeling for space-based exoplanet imagers (United States)

    Savransky, Dmitry; Delacroix, Christian; Garrett, Daniel


    In addition to the Wide-Field Infrared Survey Telescope Coronagraphic Imager (WFIRST CGI), which is currently scheduled for launch in the mid 2020s, there is an extensive, ongoing design effort for next-generation, space-based, exoplanet imaging instrumentation. This work involves mission concepts such as the Large UV/ Optical/Infrared Surveyor (LUVOIR), the Habitable Exoplanet Imaging Misson (HabEx), and a starshade rendezvous mission for WFIRST, among others. While each of these efforts includes detailed mission analysis targeted at the specifics of each design, there is also interest in being able to analyze all such concepts in a unified way (to the extent that this is possible) and to draw specific comparisons between projected concept capabilities. Here, we discuss and compare two fundamental approaches to mission analysis, full mission simulation and depth of search analysis, in the specific context of simulating and comparing multiple different mission concepts. We present strategies for mission analysis at varying stages of concept definition, using WFIRST as a motivating example, and discuss useful metrics for cross-mission comparison, as well as strategies for evaluating these metrics.

  20. Detection of Space-debris Using Space-Based Integrated Detection and Image Processing System (United States)

    Azzazy, M.; Justice, J.


    Detection and cataloguing of space-debris is paramount to satellite operations. Space debris vary in size from very small objects 10-4 m2 to large objects approximately > 1 m2. The detection of small debris using earth-based telescopes and detection systems present a great challenge; long integration time, and large blur due to atmospheric turbulence. Space-based detection systems are usually expensive and have limited image processing capabilities to detect and track space debris. In this paper we describe the development of a relatively inexpensive space-based integrated sensor/processor that allows the detection of objects as small as 10-4 m2 at 50 km range (equivalent to star magnitude 10). The sensor noise floor is equivalent to star magnitude 12. The sensor field of regard is 60°x120°. The elevation field of regard is covered by two 25 mega-pixel focal plane arrays, each with 4 cm aperture covering 30 degrees field of view. A gimbal is then used to scan the sensor in the azimuthal direction. The sensor frame rate to cover the full field of regard is 10 frames/sec. The FPA outputs are processed onboard to register the images, remove background stars, identify the debris, and determine their coordinate and sidereal motion relative to the camera frame of reference. Image registration: rotation and translation to sub-pixel level was achieved using Radon transformation and fast Fourier transform techniques. The image registration algorithm was optimized to run on an FPGA. Star background is then removed from the registered images and the location and sidereal motion of the debris are then determined. The image processing system uses stars with magnitudes between 5 and 7 along with a look-up table map of the sky to convert the debris coordinate system to an inertial coordinate system which is then transmitted to the ground. A high fidelity simulation model has been developed and used to guide and test the image processing algorithms. The high fidelity simulation

  1. Measurements of Neutron Radiation on the International Space Station: ISS-34 to ISS-40 (United States)

    Smith, Martin

    Radiation protection associated with human spaceflight is an important issue that becomes more vital as both the length of the mission and the distance from Earth increase. Radiation in deep space is a mixed field due to galactic cosmic rays (GCRs) and solar particle events (SPEs). In low-Earth orbit (LEO), protons and electrons trapped in the Van Allen radiation belts also make a major contribution to the radiation field. Neutrons encountered in LEO, for example on the International Space Station (ISS), are produced by nuclear interactions of GCRs and trapped protons with various elements in the walls and interior components of the spacecraft, and by neutron albedo after GCRs are incident on the Earth’s atmosphere. Previous investigations using bubble detectors (on Russian satellites, the Mir space station, the space shuttle, and the ISS) have shown that neutrons contribute significantly to the total biologically-equivalent radiation dose received by astronauts. As part of the ongoing Matroshka-R experiment, bubble detectors have been used to characterize neutron radiation on the ISS, starting with the ISS-13 mission in 2006. Two types of bubble detectors have been used for these experiments, namely space personal neutron dosimeters (SPNDs) and the space bubble-detector spectrometer (SBDS). The SBDS is a set of six detectors with different energy thresholds, which is used to determine the neutron energy spectrum. During the ISS-34 to ISS-40 expeditions (2012 - 2014) bubble detectors were used in both the US Orbital Segment (USOS) and the Russian segment of the ISS. The Radi-N2 experiment, a repeat of the 2009 Radi-N investigation, started during ISS-34 and included repeated measurements in four USOS modules: Columbus, the Japanese Experiment Module, the US Laboratory, and Node 2. Parallel experiments using a second set of detectors in the Russian segment included the first characterization of the neutron spectrum inside the tissue-equivalent Matroshka-R phantom

  2. MO-G-9A-01: Imaging Refresher for Standard of Care Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Labby, Z [The University of Michigan Hospital ' Health Sys, Ann Arbor, MI (United States); Sensakovic, W [Florida Hospital, Orlando, FL (United States); Hipp, E [NYULMC Clinical Cancer Center, New York, NY (United States); Altman, M [Washington University School of Medicine, St. Louis, MO (United States)


    Imaging techniques and technology which were previously the domain of diagnostic medicine are becoming increasingly integrated and utilized in radiation therapy (RT) clinical practice. As such, there are a number of specific imaging topics that are highly applicable to modern radiation therapy physics. As imaging becomes more widely integrated into standard clinical radiation oncology practice, the impetus is on RT physicists to be informed and up-to-date on those imaging modalities relevant to the design and delivery of therapeutic radiation treatments. For example, knowing that, for a given situation, a fluid attenuated inversion recovery (FLAIR) image set is most likely what the physician would like to import and contour is helpful, but may not be sufficient to providing the best quality of care. Understanding the physics of how that pulse sequence works and why it is used could help assess its utility and determine if it is the optimal sequence for aiding in that specific clinical situation. It is thus important that clinical medical physicists be able to understand and explain the physics behind the imaging techniques used in all aspects of clinical radiation oncology practice. This session will provide the basic physics for a variety of imaging modalities for applications that are highly relevant to radiation oncology practice: computed tomography (CT) (including kV, MV, cone beam CT [CBCT], and 4DCT), positron emission tomography (PET)/CT, magnetic resonance imaging (MRI), and imaging specific to brachytherapy (including ultrasound and some brachytherapy specific topics in MR). For each unique modality, the image formation process will be reviewed, trade-offs between image quality and other factors (e.g. imaging time or radiation dose) will be clarified, and typically used cases for each modality will be introduced. The current and near-future uses of these modalities and techniques in radiation oncology clinical practice will also be discussed. Learning

  3. Self-calibrated correlation imaging with k-space variant correlation functions. (United States)

    Li, Yu; Edalati, Masoud; Du, Xingfu; Wang, Hui; Cao, Jie J


    Correlation imaging is a previously developed high-speed MRI framework that converts parallel imaging reconstruction into the estimate of correlation functions. The presented work aims to demonstrate this framework can provide a speed gain over parallel imaging by estimating k-space variant correlation functions. Because of Fourier encoding with gradients, outer k-space data contain higher spatial-frequency image components arising primarily from tissue boundaries. As a result of tissue-boundary sparsity in the human anatomy, neighboring k-space data correlation varies from the central to the outer k-space. By estimating k-space variant correlation functions with an iterative self-calibration method, correlation imaging can benefit from neighboring k-space data correlation associated with both coil sensitivity encoding and tissue-boundary sparsity, thereby providing a speed gain over parallel imaging that relies only on coil sensitivity encoding. This new approach is investigated in brain imaging and free-breathing neonatal cardiac imaging. Correlation imaging performs better than existing parallel imaging techniques in simulated brain imaging acceleration experiments. The higher speed enables real-time data acquisition for neonatal cardiac imaging in which physiological motion is fast and non-periodic. With k-space variant correlation functions, correlation imaging gives a higher speed than parallel imaging and offers the potential to image physiological motion in real-time. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

  4. Using the FLUKA Monte Carlo Code to Simulate the Interactions of Ionizing Radiation with Matter to Assist and Aid Our Understanding of Ground Based Accelerator Testing, Space Hardware Design, and Secondary Space Radiation Environments (United States)

    Reddell, Brandon


    Designing hardware to operate in the space radiation environment is a very difficult and costly activity. Ground based particle accelerators can be used to test for exposure to the radiation environment, one species at a time, however, the actual space environment cannot be duplicated because of the range of energies and isotropic nature of space radiation. The FLUKA Monte Carlo code is an integrated physics package based at CERN that has been under development for the last 40+ years and includes the most up-to-date fundamental physics theory and particle physics data. This work presents an overview of FLUKA and how it has been used in conjunction with ground based radiation testing for NASA and improve our understanding of secondary particle environments resulting from the interaction of space radiation with matter.

  5. Application of Fourier-wavelet regularized deconvolution for improving image quality of free space propagation x-ray phase contrast imaging. (United States)

    Zhou, Zhongxing; Gao, Feng; Zhao, Huijuan; Zhang, Lixin


    New x-ray phase contrast imaging techniques without using synchrotron radiation confront a common problem from the negative effects of finite source size and limited spatial resolution. These negative effects swamp the fine phase contrast fringes and make them almost undetectable. In order to alleviate this problem, deconvolution procedures should be applied to the blurred x-ray phase contrast images. In this study, three different deconvolution techniques, including Wiener filtering, Tikhonov regularization and Fourier-wavelet regularized deconvolution (ForWaRD), were applied to the simulated and experimental free space propagation x-ray phase contrast images of simple geometric phantoms. These algorithms were evaluated in terms of phase contrast improvement and signal-to-noise ratio. The results demonstrate that the ForWaRD algorithm is most appropriate for phase contrast image restoration among above-mentioned methods; it can effectively restore the lost information of phase contrast fringes while reduce the amplified noise during Fourier regularization.

  6. MR imaging predictors of local control of glottic squamous cell carcinoma treated with radiation alone

    NARCIS (Netherlands)

    Ljumanovic, Redina; Langendijk, Johannes A.; van Wattingen, Menno; Schenk, Barry; Knol, Dirk L.; Leemans, C. Rene; Castelijns, Jonas A.

    Purpose: To retrospectively evaluate the prognostic significance of magnetic resonance ( MR) imaging - determined tumor parameters, especially the presence of cartilage invasion, regarding local control of glottic squamous cell carcinoma treated with radiation therapy ( RT) alone. Materials and

  7. Image slicer manufacturing: from space application to mass production (United States)

    Bonneville, Christophe; Cagnat, Jean-François; Laurent, Florence; Prieto, Eric; Ancourt, Gérard


    This presentation aims to show technical and industrial inputs to be taking into account for Image Slicer systems design and development for different types of projects from space application to mass production for multi-IFU instruments. Cybernétix has a strong experience of precision optics assembled thanks to molecular adhesion and have already manufactured 6 prototypes of image slicer subsystem (prototypes of NIRSPEC-IFU, IFS for JWST, MUSE ...) in collaboration with the Laboratoire d"Astrophysique de Marseille (LAM) and the Centre de Recherche Astronomique de Lyon (CRAL). After a brief presentation of the principle of manufacturing and assembly, we will focus on the different performances achieved in our prototypes of slicer mirrors, pupil and slit mirrors lines: an accuracy on centre of curvature position better than 15 arsec has been obtained for a stack of 30 slices. The contribution of the slice stacking to this error is lower than 4 arcsec. In spite of very thin surfaces (~ 0.9 x 40 mm for instance), a special process allows to guarantee a surface roughness about 5 nm and very few digs on the slice borders. The WFE of the mini-mirror can also be measured at a stage of the manufacturing. Different environmental tests have shown the withstanding of these assemblies to cryogenic temperature (30 K). Then, we will describe the different solutions (spherical, flat, cylindrical surfaces) and characteristics of an image slicer that can influence difficulties of manufacturing and metrology, cost, schedule and risks with regard to fabrication. Finally, the study of a mass production plan for MUSE (CRAL) composed of 24 Image Slicers of 38 slices, that"s to say 912 slices, will be exposed as an example of what can be do for multi-module instruments.

  8. Three-dimensional tomographic imaging for dynamic radiation behavior study using infrared imaging video bolometers in large helical device plasma

    Energy Technology Data Exchange (ETDEWEB)

    Sano, Ryuichi; Iwama, Naofumi [National Institute for Fusion Science, 322-6 Oroshi-cho, Toki, Gifu 509-5292 (Japan); Peterson, Byron J.; Kobayashi, Masahiro; Mukai, Kiyofumi [National Institute for Fusion Science, 322-6 Oroshi-cho, Toki, Gifu 509-5292 (Japan); SOKENDAI (The Graduate University for Advanced Studies), Hayama, Kanagawa 240-0193 (Japan); Teranishi, Masaru [Hiroshima Institute of Technology, 2-1-1, Miyake, Saeki-ku, Hiroshima 731-5193 (Japan); Pandya, Shwetang N. [Institute of Plasma Research, Near Indira Bridge, Bhat Village, Gandhinagar, Gujarat 382428 (India)


    A three-dimensional (3D) tomography system using four InfraRed imaging Video Bolometers (IRVBs) has been designed with a helical periodicity assumption for the purpose of plasma radiation measurement in the large helical device. For the spatial inversion of large sized arrays, the system has been numerically and experimentally examined using the Tikhonov regularization with the criterion of minimum generalized cross validation, which is the standard solver of inverse problems. The 3D transport code EMC3-EIRENE for impurity behavior and related radiation has been used to produce phantoms for numerical tests, and the relative calibration of the IRVB images has been carried out with a simple function model of the decaying plasma in a radiation collapse. The tomography system can respond to temporal changes in the plasma profile and identify the 3D dynamic behavior of radiation, such as the radiation enhancement that starts from the inboard side of the torus, during the radiation collapse. The reconstruction results are also consistent with the output signals of a resistive bolometer. These results indicate that the designed 3D tomography system is available for the 3D imaging of radiation. The first 3D direct tomographic measurement of a magnetically confined plasma has been achieved.

  9. Characterization of Forest Ecosystems by combined Radiative Transfer Modeling for Imaging Spectrometer and LiDAR (United States)

    Koetz, B.; Sun, G.; Morsdorf, F.; Rubio, J.; Kimes, D.; Ranson, J.


    This research was motivated by the increased information dimensionality provided by current Earth Observation systems measuring the complex and dynamic medium of the vegetated surface of the Earth. Advanced and reliable algorithms that fully exploit this enhanced Earth Observation information are needed to deliver consistent data sets of the Earth vegetation condition describing its spatial distribution and change over time. Spectral observation provided by imaging spectrometers and the waveform from large-footprint LiDAR are now available from space for forest ecosystem studies. The imaging spectrometer data contains information about the biochemical composition of the canopy foliage, and is widely used to estimate biophysical canopy parameters such as LAI and fractional cover. LiDAR responds to the vertical distribution of scatters and permits inferences about the plant structures required to supply water and mechanical support to those surfaces. Various canopy height indices derived from LiDAR waveform have been successfully used to infer forest above-ground biomass and the characterization of canopy structure. The structure parameters derived from LiDAR data can improve the accuracy and robustness of canopy parameter retrieval from imaging spectrometer by reducing uncertainties related to the canopy structure. The specific information content, inherent to the observations of imaging spectrometry and LIDAR, assesses thus different but complementary characteristics of the complex vegetation canopy. The combination of these two information dimensions offers a unique and reliable canopy characterization including information relevant to different aspects of the biochemical and biophysical properties and thus understanding of processes within forest ecosystems. A comprehensive canopy characterization of a forest ecosystem is derived from the combined remote sensing signal of imaging spectrometry and large footprint LIDAR. The inversion of two linked physically based

  10. Dual energy versus single energy MDCT: measurement of radiation dose using adult abdominal imaging protocols. (United States)

    Ho, Lisa M; Yoshizumi, Terry T; Hurwitz, Lynne M; Nelson, Rendon C; Marin, Daniele; Toncheva, Greta; Schindera, Sebastian T


    The aim of this study was to measure the radiation dose of dual-energy and single-energy multidetector computed tomographic (CT) imaging using adult liver, renal, and aortic imaging protocols. Dual-energy CT (DECT) imaging was performed on a conventional 64-detector CT scanner using a software upgrade (Volume Dual Energy) at tube voltages of 140 and 80 kVp (with tube currents of 385 and 675 mA, respectively), with a 0.8-second gantry revolution time in axial mode. Parameters for single-energy CT (SECT) imaging were a tube voltage of 140 kVp, a tube current of 385 mA, a 0.5-second gantry revolution time, helical mode, and pitch of 1.375:1. The volume CT dose index (CTDI(vol)) value displayed on the console for each scan was recorded. Organ doses were measured using metal oxide semiconductor field-effect transistor technology. Effective dose was calculated as the sum of 20 organ doses multiplied by a weighting factor found in International Commission on Radiological Protection Publication 60. Radiation dose saving with virtual noncontrast imaging reconstruction was also determined. The CTDI(vol) values were 49.4 mGy for DECT imaging and 16.2 mGy for SECT imaging. Effective dose ranged from 22.5 to 36.4 mSv for DECT imaging and from 9.4 to 13.8 mSv for SECT imaging. Virtual noncontrast imaging reconstruction reduced the total effective dose of multiphase DECT imaging by 19% to 28%. Using the current Volume Dual Energy software, radiation doses with DECT imaging were higher than those with SECT imaging. Substantial radiation dose savings are possible with DECT imaging if virtual noncontrast imaging reconstruction replaces precontrast imaging.

  11. State-Space Realization of the Wave-Radiation Force within FAST: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Duarte, T.; Sarmento, A.; Alves, M.; Jonkman, J.


    Several methods have been proposed in the literature to find a state-space model for the wave-radiation forces. In this paper, four methods were compared, two in the frequency domain and two in the time domain. The frequency-response function and the impulse response of the resulting state-space models were compared against the ones derived by the numerical code WAMIT. The implementation of the state-space module within the FAST offshore wind turbine computer-aided engineering (CAE) tool was verified, comparing the results against the previously implemented numerical convolution method. The results agreed between the two methods, with a significant reduction in required computational time when using the state-space module.

  12. Human response to high-background radiation environments on Earth and in space (United States)

    Durante, M.; Manti, L.


    The main long-term objective of the space exploration program is the colonization of the planets of the Solar System. The high cosmic radiation equivalent dose rate represents an inescapable problem for the safe establishment of permanent human settlements on these planets. The unshielded equivalent dose rate on Mars ranges between 100 and 200 mSv/year, depending on the Solar cycle and altitude, and can reach values as high as 360 mSv/year on the Moon. The average annual effective dose on Earth is about 3 mSv, nearly 85% of which comes from natural background radiation, reduced to less than 1 mSv if man-made sources and the internal exposure to Rn daughters are excluded. However, some areas on Earth display anomalously high levels of background radiation, as is the case with thorium-rich monazite bearing sand deposits where values 200 400 times higher than the world average can be found. About 2% of the world’s population live above 3 km and receive a disproportionate 10% of the annual effective collective dose due to cosmic radiation, with a net contribution to effective dose by the neutron component which is 3 4 fold that at sea level. Thus far, epidemiological studies have failed to show any adverse health effects in the populations living in these terrestrial high-background radiation areas (HBRA), which provide an unique opportunity to study the health implications of an environment that, as closely as possibly achievable on Earth, resembles the chronic exposure of future space colonists to higher-than-normal levels of ionizing radiation. Chromosomal aberrations in the peripheral blood lymphocytes from the HBRA residents have been measured in several studies because chromosomal damage represents an early biomarker of cancer risk. Similar cytogenetic studies have been recently performed in a cohort of astronauts involved in single or repeated space flights over many years. The cytogenetic findings in populations exposed to high dose-rate background radiation

  13. Estimates of radiation doses in space on the basis of current data. (United States)

    Foelsche, T


    A gross survey of data on Van Allen belt radiations, galactic cosmic radiation, and solar cosmic radiation is presented. On the basis of these data that are, in part, fragmentary and uncertain, upper and lower limits of rad doses under different amounts of mass shielding are estimated. The estimates are preliminary especially in the cases of chance encounter with solar flare protons. Generally, the relative biological effectiveness of the high energetic space radiations and their secondaries appear insufficiently known to give detailed biological or rem doses. The overall ionization dosage of the low level galactic cosmic radiation in free space is estimated to be even in solar minimum years equivalent to less than 50 rem/year or 1 rem/week. Mass shielding up to 80 g/cm2 would not reduce the ionization dosage but would shield against heavy primaries and heavy ionizing secondaries, thus reducing the biological dose. The flux of energetic protons in the maximum intensity zone of the inner Van Allen belt is by about four orders of magnitude higher, their energy and penetration power, of course, lower. A shield of 25 g/cm2 would reduce the dose rate from 20 rad/hour under 2 g/cm2 to 5 rad/hour. These proton dose rates and also the electron and X-radiation dose rates under some g/cm2 shielding of low z-number material will not constitute a radiation hazard for flights straight through the inner and outer belt in about two hours. Staying within the maximum of the inner belt for two days would, however, lead even within 25 g/cm2 depth of outer shield and body itself to a dose of 200 rad which is on the permissible limit. Extreme solar cosmic ray events or proton showers of high intensity and a duration of days occurred with a frequency of 1-4 per year during the last highly active cycle. For the penetrating, most intense high energy event of February 23, 1956, the dose within 25 g/cm2 is estimated to have been in the order of 50 rad. In most cases the dose decreased more

  14. Preliminary results from the prototype synchrotron radiation detector on space shuttle mission STS-108

    Energy Technology Data Exchange (ETDEWEB)

    Anderhub, H.; Bates, J.R.; Baetzner, D.; Baumgartner, S.; Biland, A. E-mail:; Camps, C.; Capell, M.; Commichau, V.; Djambazov, L.; Fanchiang, Y.-J.; Fluegge, G.; Fritschi, M.; Grimm, O.; Hangarter, K.; Hofer, H.; Horisberger, U.; Kan, R.; Kaestli, W.; Kenney, G.P.; Kim, G.N.; Kim, K.S.; Koutsenko, V.; Kraeber, M.; Kuipers, J.; Lebedev, A.; Lee, M.W.; Lee, S.-C.; Lewis, R.; Lustermann, W.; Pauss, F.; Rauber, T.; Ren, D.; Ren, Z.L.; Roeser, U.; Son, D.; Ting, Samuel C.C.; Tiwari, A.N.; Viertel, G.M.; Gunten, H. von; Wicki, S. Waldmeier; Wang, T.-S.; Yang, J.; Zimmermann, B


    A Synchrotron Radiation Detector measures synchrotron radiation emitted by high energetic particles in the earth magnetic field. This allows to identify cosmic ray electrons and positrons with energies in the TeV region. One possibility for such a detector outside the atmosphere uses YAP crystals to measure synchrotron photons with energies in the keV range. As such a detector can not distinguish between photons and electrons, the main problems are the diffuse cosmic ray gamma background and low energetic electrons in the vicinity of the earth. While the intensity of the diffuse gamma rays is known quite well, there exists limited knowledge about keV-electrons in low earth orbits. To measure these electrons a Prototype Synchrotron Radiation Detector (PSRD) was flown with Space Shuttle mission STS-108 (Dec.2001) and preliminary analysis of the data show very favorable results.

  15. Modular, thermal bus-to-radiator integral heat exchanger design for Space Station Freedom (United States)

    Chambliss, Joe; Ewert, Michael


    The baseline concept is introduced for the 'integral heat exchanger' (IHX) which is the interface of the two-phase thermal bus with the heat-rejecting radiator panels. A direct bus-to-radiator heat-pipe integral connection replaces the present interface hardware to reduce the weight and complexity of the heat-exchange mechanism. The IHX is presented in detail and compared to the baseline system assuming certain values for heat rejection, mass per unit width, condenser capacity, contact conductance, and assembly mass. The spreadsheet comparison can be used to examine a variety of parameters such as radiator length and configuration. The IHX is shown to permit the reduction of panel size and system mass in response to better conductance and packaging efficiency. The IHX is found to be a suitable heat-rejection system for the Space Station Freedom because it uses present technology and eliminates the interface mechanisms.

  16. A simple model of space radiation damage in GaAs solar cells (United States)

    Wilson, J. W.; Stith, J. J.; Stock, L. V.


    A simple model is derived for the radiation damage of shallow junction gallium arsenide (GaAs) solar cells. Reasonable agreement is found between the model and specific experimental studies of radiation effects with electron and proton beams. In particular, the extreme sensitivity of the cell to protons stopping near the cell junction is predicted by the model. The equivalent fluence concept is of questionable validity for monoenergetic proton beams. Angular factors are quite important in establishing the cell sensitivity to incident particle types and energies. A fluence of isotropic incidence 1 MeV electrons (assuming infinite backing) is equivalent to four times the fluence of normal incidence 1 MeV electrons. Spectral factors common to the space radiations are considered, and cover glass thickness required to minimize the initial damage for a typical cell configuration is calculated. Rough equivalence between the geosynchronous environment and an equivalent 1 MeV electron fluence (normal incidence) is established.

  17. Metal Hydrides, MOFs, and Carbon Composites as Space Radiation Shielding Mitigators (United States)

    Atwell, William; Rojdev, Kristina; Liang, Daniel; Hill, Matthew


    Recently, metal hydrides and MOFs (Metal-Organic Framework/microporous organic polymer composites - for their hydrogen and methane storage capabilities) have been studied with applications in fuel cell technology. We have investigated a dual-use of these materials and carbon composites (CNT-HDPE) to include space radiation shielding mitigation. In this paper we present the results of a detailed study where we have analyzed 64 materials. We used the Band fit spectra for the combined 19-24 October 1989 solar proton events as the input source term radiation environment. These computational analyses were performed with the NASA high energy particle transport/dose code HZETRN. Through this analysis we have identified several of the materials that have excellent radiation shielding properties and the details of this analysis will be discussed further in the paper.

  18. Dynamics of magnetically trapped particles foundations of the physics of radiation belts and space plasmas

    CERN Document Server

    Roederer, Juan G


    This book is a new edition of Roederer’s classic Dynamics of Geomagnetically Trapped Radiation, updated and considerably expanded. The main objective is to describe the dynamic properties of magnetically trapped particles in planetary radiation belts and plasmas and explain the physical processes involved from the theoretical point of view. The approach is to examine in detail the orbital and adiabatic motion of individual particles in typical configurations of magnetic and electric fields in the magnetosphere and, from there, derive basic features of the particles’ collective “macroscopic” behavior in general planetary environments. Emphasis is not on the “what” but on the “why” of particle phenomena in near-earth space, providing a solid and clear understanding of the principal basic physical mechanisms and dynamic processes involved. The book will also serve as an introduction to general space plasma physics, with abundant basic examples to illustrate and explain the physical origin of diff...

  19. Subcritical Growth of Electron Phase-space Holes in Planetary Radiation Belts (United States)

    Osmane, Adnane; Turner, Drew L.; Wilson, Lynn B.; Dimmock, Andrew P.; Pulkkinen, Tuija I.


    The discovery of long-lived electrostatic coherent structures with large-amplitude electric fields (1≤slant E ≤slant 500 mV/m) by the Van Allen Probes has revealed alternative routes through which planetary radiation belts’ acceleration can take place. Following previous reports showing that small phase-space holes, with qφ /{T}ec≃ {10}-2{--}{10}-3, could result from electron interaction with large-amplitude whistlers, we demonstrate one possible mechanism through which holes can grow nonlinearly (I.e., γ \\propto \\sqrt{φ }) and subcritically as a result of momentum exchange between hot and cold electron populations. Our results provide an explanation for the common occurrence and fast growth of large-amplitude electron phase-space holes in the Earth’s radiation belts.

  20. Development and Characterization of Tissue Equivalent Proportional Counter for Radiation Monitoring in International Space Station

    Directory of Open Access Journals (Sweden)

    Uk-Won Nam


    Full Text Available Tissue equivalent proportional counter (TEPC can measure the Linear Energy Transfer (LET spectrum and calculate the equivalent dose for the complicated radiation field in space. In this paper, we developed and characterized a TEPC for radiation monitoring in International Space Station (ISS. The prototype TEPC which can simulate a 2 μm of the site diameter for micro-dosimetry has been tested with a standard alpha source (241Am, 5.5 MeV. Also, the calibration of the TEPC was performed by the 252Cf neutron standard source in Korea Research Institute of Standards and Science (KRISS. The determined calibration factor was kf = 3.59×10-7 mSv/R.

  1. Space Photovoltaic Concentrator Using Robust Fresnel Lenses, 4-Junction Cells, Graphene Radiators, and Articulating Receivers (United States)

    O'Neill, Mark; McDanal, A. J.; Brandhorst, Henry; Spence, Brian; Iqbal, Shawn; Sharps, Paul; McPheeters, Clay; Steinfeldt, Jeff; Piszczor, Michael; Myers, Matt


    At the 42nd PVSC, our team presented recent advances in our space photovoltaic concentrator technology. These advances include more robust Fresnel lenses for optical concentration, more thermally conductive graphene radiators for waste heat rejection, improved color-mixing lens technology to minimize chromatic aberration losses with 4-junction solar cells, and an articulating photovoltaic receiver enabling single-axis sun-tracking, while maintaining a sharp focal line despite large beta angles of incidence. In the past year, under a NASA Phase II SBIR program, our team has made much additional progress in the development of this new space photovoltaic concentrator technology, as described in this paper.

  2. Implementation of adaptive radiation therapy for urinary bladder carcinoma - Imaging, planning and image guidance

    Energy Technology Data Exchange (ETDEWEB)

    Tuomikoski, Laura; Collan, Juhani; Keyrilaeinen, Jani; Saarilahti, Kauko; Tenhunen, Mikko [Dept. of Oncology, Helsinki Univ. Central Hospital, Helsinki (Finland)], e-mail:; Korhonen, Juha [Dept. of Oncology, Helsinki Univ. Central Hospital, Helsinki (Finland); Clinical Research Inst. Helsinki Univ. Central Hospital Ltd, Helsinki (Finland); Visapaeae, Harri [Dept. of Oncology, Helsinki Univ. Central Hospital, Helsinki (Finland); Dept. of Urology, Helsinki Univ. Central Hospital, Helsinki (Finland); Sairanen, Jukka [Dept. of Urology, Helsinki Univ. Central Hospital, Helsinki (Finland)


    Background: Adaptive radiation therapy (ART) for urinary bladder cancer has emerged as a promising alternative to conventional RT with potential to minimize radiation-induced toxicity to healthy tissues. In this work we have studied bladder volume variations and their effect on healthy bladder dose sparing and intra fractional margins, in order to refine our ART strategy. Material and methods: An online ART treatment strategy was followed for five patients with urinary bladder cancer with the tumors demarcated using Lipiodol. A library of 3-4 predefined treatment plans for each patient was created based on four successive computed tomography (CT) scans. Cone beam CT (CBCT) images were acquired before each treatment fraction and after the treatment at least weekly. In partial bladder treatment the sparing of the healthy part of the bladder was investigated. The bladder wall displacements due to bladder filling were determined in three orthogonal directions (CC, AP, DEX-SIN) using the treatment planning CT scans. An ellipsoidal model was applied in order to find the theoretical maximum values for the bladder wall displacements. Moreover, the actual bladder filling rate during treatment was evaluated using the CBCT images. Results: In partial bladder treatment the volume of the bladder receiving high absorbed doses was generally smaller with a full than empty bladder. The estimation of the bladder volume and the upper limit for the intra fractional movement of the bladder wall could be represented with an ellipsoidal model with a reasonable accuracy. Observed maximum growth of bladder dimensions was less than 10 mm in all three orthogonal directions during 15 minute interval. Conclusion: The use of Lipiodol contrast agent enables partial bladder treatment with reduced irradiation of the healthy bladder volume. The ellipsoidal bladder model can be used for the estimation of the bladder volume changes and the upper limit of the bladder wall movement during the treatment

  3. Emittance growth due to static and radiative space charge forces in an electron bunch compressor

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    Richard Talman


    2004 FEL Conference, pp. 18–21, MOCOS05, available at], a code with similar capabilities. For this comparison an appropriately new, 50 MeV, “standard chicane” is introduced. Unlike CSRTrack (which neglects vertical forces the present simulation shows substantial growth of vertical emittance. But “turning off” vertical forces in the UAL code (to match the CSRTrack treatment brings the two codes into excellent agreement. (iii Results are also obtained for 5 GeV electrons passing through a previously introduced “standard chicane” [Coherent Synchrotron Radiation, CSR Workshop, Berlin 2002,] [of the sort needed for linear colliders and free electron lasers (FEL’s currently under design or construction]. Relatively little emittance growth is predicted for typical bunch parameters at such high electron energy. Results are obtained for both round beams and ribbon beams (like those actually needed in practice. Little or no excess emittance growth is found for ribbon bunches compared to round bunches of the same charge and bunch width. The UAL string space charge formulation (like TraFic4 and CSRTrack avoids the regularization step (subtracting the free-space space charge force which is required (to remove divergence in some methods. Also, by avoiding the need to calculate a retarded-time, four-dimensional field history, the computation time needed for realistic bunch evolution calculations is modest. Some theories of bunch dilution, because they ascribe emittance growth entirely to CSR, break down at low energy. In the present treatment, as well as CSR, all free-space Coulomb and magnetic space charge forces (but not image forces, and also the centrifugal space charge force (CSCF are included. Charge-dependent beam steering due to CSCF, as observed recently by Beutner et al. [B. Beutner et al., in Proceedings of FEL Conference, BESSY, Berlin, Germany, 2006, MOPPH009], is also investigated.

  4. Optimized radiation-hardened erbium doped fiber amplifiers for long space missions (United States)

    Ladaci, A.; Girard, S.; Mescia, L.; Robin, T.; Laurent, A.; Cadier, B.; Boutillier, M.; Ouerdane, Y.; Boukenter, A.


    In this work, we developed and exploited simulation tools to optimize the performances of rare earth doped fiber amplifiers (REDFAs) for space missions. To describe these systems, a state-of-the-art model based on the rate equations and the particle swarm optimization technique is developed in which we also consider the main radiation effect on REDFA: the radiation induced attenuation (RIA). After the validation of this tool set by confrontation between theoretical and experimental results, we investigate how the deleterious radiation effects on the amplifier performance can be mitigated following adequate strategies to conceive the REDFA architecture. The tool set was validated by comparing the calculated Erbium-doped fiber amplifier (EDFA) gain degradation under X-rays at ˜300 krad(SiO2) with the corresponding experimental results. Two versions of the same fibers were used in this work, a standard optical fiber and a radiation hardened fiber, obtained by loading the previous fiber with hydrogen gas. Based on these fibers, standard and radiation hardened EDFAs were manufactured and tested in different operating configurations, and the obtained data were compared with simulation data done considering the same EDFA structure and fiber properties. This comparison reveals a good agreement between simulated gain and experimental data (architecture evolutions in the amplifier performance during the space mission. Optimization of both the fiber length and the EDFA pumping scheme allows us to strongly reduce its radiation vulnerability in terms of gain. The presented approach is a complementary and effective tool for hardening by device techniques and opens new perspectives for the applications of REDFAs and lasers in harsh environments.

  5. Space Photovoltaic Research and Technology 1983. High Efficiency, Radiation Damage, and Blanket Technology (United States)


    This three day conference, sixth in a series that began in 1974, was held at the NASA Lewis Research Center on October 18-20, 1983. The conference provided a forum for the discussion of space photovoltaic systems, their research status, and program goals. Papers were presented and workshops were held in a variety of technology areas, including basic cell research, advanced blanket technology, and radiation damage.

  6. On the potential impact of the newly proposed quality factors on space radiation protection (United States)

    Wilson, John W.; Townsend, Lawrence W.; Cucinotta, Francis A.


    The recently proposed changes in the defined quality factor hold great potential for easing some of the protection requirements from electrons and protons in the near-Earth environment. At the same time, the high Linear Energy Transfer (LET) components play an even more important role which must be further evaluated. Several recommendations are made which need to be addressed before these new quality factors can be implemented into space radiation potection practice.

  7. Evolution of organic molecules under Mars-like UV radiation conditions in space and laboratory