Lack of adaptation to human tetherin in HIV-1 Group O and P

Directory of Open Access Journals (Sweden)

Haworth Kevin G

2011-09-01

Full Text Available Abstract Background HIV-1 viruses are categorized into four distinct groups: M, N, O and P. Despite the same genomic organization, only the group M viruses are responsible for the world-wide pandemic of AIDS, suggesting better adaptation to human hosts. Previously, it has been reported that the group M Vpu protein is capable of both down-modulating CD4 and counteracting BST-2/tetherin restriction, while the group O Vpu cannot antagonize tetherin. This led us to investigate if group O, and the related group P viruses, possess functional anti-tetherin activities in Vpu or another viral protein, and to further map the residues required for group M Vpu to counteract human tetherin. Results We found a lack of activity against human tetherin for both the Vpu and Nef proteins from group O and P viruses. Furthermore, we found no evidence of anti-human tetherin activity in a fully infectious group O proviral clone, ruling out the possibility of an alternative anti-tetherin factor in this virus. Interestingly, an activity against primate tetherins was retained in the Nef proteins from both a group O and a group P virus. By making chimeras between a functional group M and non-functional group O Vpu protein, we were able to map the first 18 amino acids of group M Vpu as playing an essential role in the ability of the protein to antagonize human tetherin. We further demonstrated the importance of residue alanine-18 for the group M Vpu activity. This residue lies on a diagonal face of conserved alanines in the TM domain of the protein, and is necessary for specific Vpu-tetherin interactions. Conclusions The absence of human specific anti-tetherin activities in HIV-1 group O and P suggests a failure of these viruses to adapt to human hosts, which may have limited their spread.

From spin groups and modular P{sub 1}CT symmetry to covariant representations and the spin-statistics theorem

Energy Technology Data Exchange (ETDEWEB)

Lorenzen, R.

2007-03-15

Starting from the assumption of modular P{sub 1}CT symmetry in quantum field theory a representation of the universal covering of the Poincar'e group is constructed in terms of pairs of modular conjugations. The modular conjugations are associated with field algebras of unbounded operators localised in wedge regions. It turns out that an essential step consists in characterising the universal covering group of the Lorentz group by pairs of wedge regions, in conjunction with an analysis of its geometrical properties. In this thesis two approaches to this problem are developed in four spacetime dimensions. First a realisation of the universal covering as the quotient space over the set of pairs of wedge regions is presented. In spite of the intuitive definition, the necessary properties of a covering space are not straightforward to prove. But the geometrical properties are easy to handle. The second approach takes advantage of the well-known features of spin groups, given as subgroups of Clifford algebras. Characterising elements of spin groups by pairs of wedge regions is possible in an elegant manner. The geometrical analysis is performed by means of the results achieved in the first approach. These geometrical properties allow for constructing a representation of the universal cover of the Lorentz group in terms of pairs of modular conjugations. For this representation the derivation of the spin-statistics theorem is straightforward, and a PCT operator can be defined. Furthermore, it is possible to transfer the results to nets of field algebras in algebraic quantum field theory with ease. Many of the usual assumptions in quantum field theory like the spectrum condition or the existence of a covariant unitary representation, as well as the assumption on the quantum field to have only finitely many components, are not required. For the standard axioms, the crucial assumption of modular P{sub 1}CT symmetry constitutes no loss of generality because it is a

Hazy spaces, tangent spaces, manifolds and groups

International Nuclear Information System (INIS)

Dodson, C.T.J.

1977-03-01

The results on hazy spaces and the developments leading to hazy manifolds and groups are summarized. Proofs have appeared elsewhere so here examples are considered and some motivation for definitions and constructions in the theorems is analyzed. It is shown that quite simple ideas, intuitively acceptable, lead to remarkable similarity with the theory of differentiable manifolds. Hazy n manifolds have tangent bundles that are hazy 2n manifolds and there are hazy manifold structures for groups. Products and submanifolds are easily constructed and in particular the hazy n-sphere manifolds as submanifolds of the standard hazy manifold Zsup(n+1)

Selenomethionine substitution of orotidine-5-monophosphate decarboxylase causes a change in crystal contacts and space group

DEFF Research Database (Denmark)

Poulsen, Jens-Christian Navarro; Harris, Pernille; Jensen, Kaj Frank

2001-01-01

with the inhibitor 1-(5'-phospho- -D-ribofuranosyl)barbituric acid crystallizes under similar conditions as the native enzyme. In contrast to the native enzyme, where the crystals belong to the orthorhombic space group P212121, the SeMet-substituted enzyme crystallizes in the monoclinic space group P21......-wavelength anomalous dispersion technique, both native and SeMet-substituted proteins have been produced and purified. During the production of SeMet ODCase, it was observed that SeMet was the only amino acid that it was necessary to add to the defined medium during expression. SeMet-substituted ODCase in complex...

On signature change in p-adic space-times

International Nuclear Information System (INIS)

Dragovic, B.G.

1991-01-01

Change of signature by linear coordinate transformations in p-adic space-times is considered. In this paper it is shown that there exists arbitrary change of trivial signature in Q p n for all n ≥ 1 if p ≡ 1 (mod 4). In other cases it is possible to change only even number of the signs of the signature. The authors suggest new concept of signature with respect to distinct quadratic extensions, of Q p . If space-time dimension is restricted to four there is no signature change

R-102, 1 Group Space-Independent Inverse Reactor Kinetics

International Nuclear Information System (INIS)

Kaganove, J.J.

1966-01-01

1 - Description of problem or function: Given the space-independent, one energy group reactor kinetics equations and the initial conditions, this program determines the time variation of reactivity required to produce the given input of flux-time data. 2 - Method of solution: Time derivatives of neutron density are obtained by application of (a) five-point quartic, (b) three-point parabolic, (c) five-point least-mean-square cubic, (d) five-point least-mean-square parabolic, or (e) five-point least-mean-square linear formulae to the neutron density or to the natural logarithm of the neutron density. Between each data point the neutron density is assumed to be (a) exponential*(third-order polynomial), (b) exponential, or (c) linear. Changes in reactivity between data points are obtained algebraically from the kinetics equations, neutron density derivatives, and the algebraic representation of neutron density. First and second time derivatives of the reactivity are obtained by use of any of the formulae applicable to the neutron density. 3 - Restrictions on the complexity of the problem: Maxima of - 50 delay groups; 1000 data points; 99 data blocks (A data block is a sequence of input points characterized by a fixed time-interval between points, a smoothing option, and a number of repetitions of the smoothing option)

Arithmetically Cohen-Macaulay sets of points in P^1 x P^1

CERN Document Server

Guardo, Elena

2015-01-01

This brief presents a solution to the interpolation problem for arithmetically Cohen-Macaulay (ACM) sets of points in the multiprojective space P^1 x P^1.  It collects the various current threads in the literature on this topic with the aim of providing a self-contained, unified introduction while also advancing some new ideas.  The relevant constructions related to multiprojective spaces are reviewed first, followed by the basic properties of points in P^1 x P^1, the bigraded Hilbert function, and ACM sets of points.  The authors then show how, using a combinatorial description of ACM points in P^1 x P^1, the bigraded Hilbert function can be computed and, as a result, solve the interpolation problem.  In subsequent chapters, they consider fat points and double points in P^1 x P^1 and demonstrate how to use their results to answer questions and problems of interest in commutative algebra.  Throughout the book, chapters end with a brief historical overview, citations of related results, and, where relevan...

Space groups for solid state scientists

CERN Document Server

Glazer, Michael; Glazer, Alexander N

2014-01-01

This Second Edition provides solid state scientists, who are not necessarily experts in crystallography, with an understandable and comprehensive guide to the new International Tables for Crystallography. The basic ideas of symmetry, lattices, point groups, and space groups are explained in a clear and detailed manner. Notation is introduced in a step-by-step way so that the reader is supplied with the tools necessary to derive and apply space group information. Of particular interest in this second edition are the discussions of space groups application to such timely topics as high-te

Group-velocity dispersion effects on quantum noise of a fiber optical soliton in phase space

International Nuclear Information System (INIS)

Ju, Heongkyu; Lee, Euncheol

2010-01-01

Group-velocity dispersion (GVD) effects on quantum noise of ultrashort pulsed light are theoretically investigated at the soliton energy level, using Gaussian-weighted pseudo-random distribution of phasors in phase space for the modeling of quantum noise properties including phase noise, photon number noise, and quantum noise shape in phase space. We present the effects of GVD that mixes the different spectral components in time, on the self-phase modulation(SPM)-induced quantum noise properties in phase space such as quadrature squeezing, photon-number noise, and tilting/distortion of quantum noise shape in phase space, for the soliton that propagates a distance of the nonlinear length η NL = 1/( γP 0 ) (P 0 is the pulse peak power and γ is the SPM parameter). The propagation dependence of phase space quantum noise properties for an optical soliton is also provided.

Export of Cytochrome P450 105D1 to the Periplasmic Space of Escherichia coli

OpenAIRE

Kaderbhai, Mustak A.; Ugochukwu, Cynthia C.; Kelly, Steven L.; Lamb, David C.

2001-01-01

CYP105D1, a cytochrome P450 from Streptomyces griseus, was appended at its amino terminus to the secretory signal of Escherichia coli alkaline phosphatase and placed under the transcriptional control of the native phoA promoter. Heterologous expression in E. coli phosphate-limited medium resulted in abundant synthesis of recombinant CYP105D1 that was translocated across the bacterial inner membrane and processed to yield authentic, heme-incorporated P450 within the periplasmic space. Cell ext...

The cohomology of orbit spaces of certain free circle group actions

Indian Academy of Sciences (India)

Abstract. Suppose that G = S1 acts freely on a finitistic space X whose (mod p) cohomology ring is isomorphic to that of a lens space L2m−1(p;q1,...,qm) or S1 ×. CPm−1. The mod p index of the action is defined to be the largest integer n such that αn = 0, where α ϵ H2(X/G; Zp) is the nonzero characteristic class of the S1-.

The Lp Spectrum of Locally Symmetric Spaces with Small Fundamental Group

International Nuclear Information System (INIS)

Weber, Andreas

2009-01-01

We determine the L p spectrum of the Laplace-Beltrami operator on certain complete locally symmetric spaces M whose universal covering X is a symmetric space of non-compact type with rank one. More precisely, we show that the L p spectra of M and X coincide if the fundamental group of M is small and if the injectivity radius of M is bounded away from zero. In the L 2 case, the restriction on the injectivity radius is not needed

[Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes].

Science.gov (United States)

Bao, X H; Li, H X; Tao, J; Li, X M; Yang, Y N; Ma, Y T; Chen, B D

2016-05-24

To study the role and mechanism of sphingosine-1-phosphate (S1P)/ sphingosine-1-phosphate receptor 1(S1P1) signal pathway during post conditioning of hypertrophic cardiomyocytes. Neonatal rat cardiomyocytes were isolated and cultured, then stimulated by norepinephrine (NE) to induce cardiomyocytes hypertrophy. Using tri-gas incubator to create hypoxia and reoxygenation enviroment to mimic ischemia-reperfusion and postconditioning. Hypertrophic cardiomyoctyes were divided into five groups according to the presence or absence of various drugs and postconditiong and relevant signal pathways changes were detected: (1) IPost group (hypoxia+ postconditioning); (2) IPost+ S1P group (cells were pretreated with S1P (1 μmol/L) for 2 h before IPost); (3) IPost+ W-146+ S1P group (cells in IPost+ W-146+ S1P group were pretreated with S1P1 inhibitor W-146 (0.4 μmol/L) for 20 min); (4) IPost+ PD98059+ S1P group (cells in IPost+ S1P group were pretreated with MAPK antagonist PD98059 (125 μmol/L) for 20 min); (5) IPost+ LY-294002+ S1P group (cells in IPost+ S1P group were pretreated with PI3K antagonist LY294002 (0.1 μmol/L) for 20 min). Apoptosis was detected by flow cytometry and protein expression of relevant signal pathways were detected by Western blot. (1)Apoptosis rate was significantly increased in hypoxia/reoxygenation (27.90±4.49)% group compared with normal control group (7.97±2.18)%, which could be significantly reduced in IPost group (15.90±1.77)% (all PS1P and IPost+ S1P+ LY-294002 groups than in IPost and IPost+ S1P+ W-146 and IPost+ S1P+ PD98059 group (all PS1P and IPost+ S1P+ LY-294002 group than in IPost and IPost+ S1P+ W-146 group and IPost+ S1P+ PD98059 group (all PS1P+ W-146 and IPost+ S1P+ PD98059 groups. p-ERK1/2 and p-Akt levels in IPost+ S1P+ W-146 group and IPost+ S1P+ PD98059 were similar as in IPost group. S1P can play protective role on NE induced cardiomyocytes hypertrophy during post conditioning through downregulating caspase-3 expression and

Mapping spaces and automorphism groups of toric noncommutative spaces

Science.gov (United States)

Barnes, Gwendolyn E.; Schenkel, Alexander; Szabo, Richard J.

2017-09-01

We develop a sheaf theory approach to toric noncommutative geometry which allows us to formalize the concept of mapping spaces between two toric noncommutative spaces. As an application, we study the `internalized' automorphism group of a toric noncommutative space and show that its Lie algebra has an elementary description in terms of braided derivations.

Comparative study of the dust emission of 19P/Borrelly (Deep Space 1) and 1P/Halley

Science.gov (United States)

Ho, T.-M.; Thomas, N.; Boice, D.C.; Kollein, C.; Soderblom, L.A.

2003-01-01

Images obtained by the Miniature Integrated Camera and Imaging Spectrometer (MICAS) experiment onboard the Deep Space 1 spacecraft which encountered comet 19P/Borrelly on September 22nd 2001 show a dust coma dominated by jets. In particular a major collimated dust jet on the sunward side of the nucleus was observed. Our approach to analyse these features is to integrate the observed intensity in concentric envelopes around the nucleus. The same procedures has been used on the Halley Multicolour Camera images of comet 1P/Halley acquired on March 14th 1986. We are able to show that at Borrelly the dust brightness dependence as a function of radial distance is different to that of Halley. At large distances both comets show constant values as the size of the concentric envelopes increases (as one would expect for force free radial outflow). For Halley the integral decreases as one gets closer to the nucleus. Borrelly shows opposite behaviour. The main cause for Halley's intensity distribution is either high optical thickness or particle fragmentation. For Borrelly, we have constructed a simple model of the brightness distribution near the nucleus. This indicates that the influence of deviations from point source geometry is insufficient to explain the observed steepening of the intensity profile close to the nucleus. Dust acceleration or fragmentation into submicron particles appear to be required. We also estimate the dust production rate of Borrelly with respect to Halley and compare their dust to gas ratios. ?? 2003 COSPAR. Published by Elsevier Ltd. All rights reserved.

The space shuttle payload planning working groups: Volume 9: Materials processing and space manufacturing

Science.gov (United States)

1973-01-01

The findings and recommendations of the Materials Processing and Space Manufacturing group of the space shuttle payload planning activity are presented. The effects of weightlessness on the levitation processes, mixture stability, and control over heat and mass transport in fluids are considered for investigation. The research and development projects include: (1) metallurgical processes, (2) electronic materials, (3) biological applications, and (4)nonmetallic materials and processes. Additional recommendations are provided concerning the allocation of payload space, acceptance of experiments for flight, flight qualification, and private use of the space shuttle.

Quantum group gauge theory on quantum spaces

International Nuclear Information System (INIS)

Brzezinski, T.; Majid, S.

1993-01-01

We construct quantum group-valued canonical connections on quantum homogeneous spaces, including a q-deformed Dirac monopole on the quantum sphere of Podles quantum differential coming from the 3-D calculus of Woronowicz on SU q (2). The construction is presented within the setting of a general theory of quantum principal bundles with quantum group (Hopf algebra) fiber, associated quantum vector bundles and connection one-forms. Both the base space (spacetime) and the total space are non-commutative algebras (quantum spaces). (orig.)

Canadian space agency discipline working group for space dosimetry and radiation science

International Nuclear Information System (INIS)

Waker, Anthony; Waller, Edward; Lewis, Brent; Bennett, Leslie; Conroy, Thomas

2008-01-01

Full text: One of the great technical challenges in the human and robotic exploration of space is the deleterious effect of radiation on humans and physical systems. The magnitude of this challenge is broadly understood in terms of the sources of radiation, however, a great deal remains to be done in the development of instrumentation, suitable for the space environment, which can provide real-time monitoring of the complex radiation fields encountered in space and a quantitative measure of potential biological risk. In order to meet these research requirements collaboration is needed between experimental nuclear instrumentation scientists, theoretical scientists working on numerical modeling techniques and radiation biologists. Under the auspices of the Canadian Space Agency such a collaborative body has been established as one of a number of Discipline Working Groups. Members of the Space Dosimetry and Radiation Science working group form a collaborative network across Canada including universities, government laboratories and the industrial sector. Three central activities form the core of the Space Dosimetry and Radiation Science DWG. An instrument sub-group is engaged in the development of instruments capable of gamma ray, energetic charged particle and neutron dosimetry including the ability to provide dosimetric information in real-time. A second sub-group is focused on computer modeling of space radiation fields in order to assess the performance of conceptual designs of detectors and dosimeters or the impact of radiation on cellular and sub-cellular biological targets and a third sub-group is engaged in the study of the biological effects of space radiation and the potential of biomarkers as a method of assessing radiation impact on humans. Many working group members are active in more than one sub-group facilitating communication throughout the whole network. A summary progress-report will be given of the activities of the Discipline Working Group and the

Polycomb Group Protein PHF1 Regulates p53-dependent Cell Growth Arrest and Apoptosis*

Science.gov (United States)

Yang, Yang; Wang, Chenji; Zhang, Pingzhao; Gao, Kun; Wang, Dejie; Yu, Hongxiu; Zhang, Ting; Jiang, Sirui; Hexige, Saiyin; Hong, Zehui; Yasui, Akira; Liu, Jun O.; Huang, Haojie; Yu, Long

2013-01-01

Polycomb group protein PHF1 is well known as a component of a novel EED-EZH2·Polycomb repressive complex 2 complex and plays important roles in H3K27 methylation and Hox gene silencing. PHF1 is also involved in the response to DNA double-strand breaks in human cells, promotes nonhomologous end-joining processes through interaction with Ku70/Ku80. Here, we identified another function of PHF1 as a potential p53 pathway activator in a pathway screen using luminescence reporter assay. Subsequent studies showed PHF1 directly interacts with p53 proteins both in vivo and in vitro and co-localized in nucleus. PHF1 binds to the C-terminal regulatory domain of p53. Overexpression of PHF1 elevated p53 protein level and prolonged its turnover. Knockdown of PHF1 reduced p53 protein level and its target gene expression both in normal state and DNA damage response. Mechanically, PHF1 protects p53 proteins from MDM2-mediated ubiquitination and degradation. Furthermore, we showed that PHF1 regulates cell growth arrest and etoposide-induced apoptosis in a p53-dependent manner. Finally, PHF1 expression was significantly down-regulated in human breast cancer samples. Taken together, we establish PHF1 as a novel positive regulator of the p53 pathway. These data shed light on the potential roles of PHF1 in tumorigenesis and/or tumor progression. PMID:23150668

Sobolev Spaces on Locally Compact Abelian Groups: Compact Embeddings and Local Spaces

Directory of Open Access Journals (Sweden)

Przemysław Górka

2014-01-01

Full Text Available We continue our research on Sobolev spaces on locally compact abelian (LCA groups motivated by our work on equations with infinitely many derivatives of interest for string theory and cosmology. In this paper, we focus on compact embedding results and we prove an analog for LCA groups of the classical Rellich lemma and of the Rellich-Kondrachov compactness theorem. Furthermore, we introduce Sobolev spaces on subsets of LCA groups and study its main properties, including the existence of compact embeddings into Lp-spaces.

The classification of p-compact groups for p odd

DEFF Research Database (Denmark)

Andersen, Kasper K. S.; Grodal, Jesper Kragh; Møller, Jesper Michael

2008-01-01

A p-compact group, as defined by Dwyer and Wilkerson, is a purely homotopically defined p-local analog of a compact Lie group. It has long been the hope, and later the conjecture, that these objects should have a classification similar to the classification of compact Lie groups. In this paper we...... groups are uniquely determined as p-compact groups by their Weyl groups seen as finite reflection groups over the p-adic integers. Our approach in fact gives a largely self-contained proof of the entire classification theorem for p odd....

Noncommutative phase spaces on Aristotle group

Directory of Open Access Journals (Sweden)

Ancille Ngendakumana

2012-03-01

Full Text Available We realize noncommutative phase spaces as coadjoint orbits of extensions of the Aristotle group in a two dimensional space. Through these constructions the momenta of the phase spaces do not commute due to the presence of a naturally introduced magnetic eld. These cases correspond to the minimal coupling of the momentum with a magnetic potential.

Retabulation of space group extinctions for electron diffraction

International Nuclear Information System (INIS)

Goodman, P.; Tanaka, M.

1989-01-01

The space group tables previously published by one of the authors and others are here presented in a revised and compacted form designed to make for compatability with existing tables for X-ray diffraction. 136 of the 230 space groups are subject to dynamic extinctions due to glide planes and screw axes, and the observables from these space groups in specific settings are tabulated. Tabs

Group structure and group process for effective space station astronaut teams

Science.gov (United States)

Nicholas, J. M.; Kagan, R. S.

1985-01-01

Space Station crews will encounter new problems, many derived from the social interaction of groups working in space for extended durations. Solutions to these problems must focus on the structure of groups and the interaction of individuals. A model of intervention is proposed to address problems of interpersonal relationships and emotional stress, and improve the morale, cohesiveness, and productivity of astronaut teams.

Student Facebook groups as a third space

DEFF Research Database (Denmark)

Aaen, Janus Holst; Dalsgaard, Christian

2016-01-01

-institutional, personal space of the Facebook network. The main study of the article examines six student-managed Facebook groups and provides an analysis of a total of 2247 posts and 12,217 comments. Furthermore, the study draws on group interviews with students from 17 Danish upper secondary schools and a survey......The paper examines educational potentials of Facebook groups that are created and managed by students without any involvement from teachers. The objective is to study student-managed Facebook groups as a ‘third space' between the institutional space of teacher-managed Facebook groups and the non...... answered by 932 students from 25 schools. Based on the survey and interviews, the paper concludes that Facebook is an important educational tool for students in Danish upper secondary schools to receive help on homework and assignments. Furthermore, on the basis of the analysis of Facebook groups...

The coadjoint orbit spaces of Diff(S1) and Teichmueller spaces

International Nuclear Information System (INIS)

Nag, S.; Verjovsky, A.

1989-09-01

Precisely two of the homogeneous spaces that appear as coadjoint orbits of the group of string reparametrizations (Diff (S 1 )) carry in a natural way the structure of infinite dimensional, holomorphically homogeneous complex analytic Kaehler manifolds. These are N = Diff (S 1 )/Rot (S 1 ) and M = Diff (S 1 )/Moeb (S 1 ). Note that N is a holomorphic disc fiber space over M. Now, M can be naturally considered as embedded in the classical universal Teichmueller space T(1), simply by noting that a diffeomorphism of S 1 is a quasisymmetric homeomorphism. T(1) is itself a homomorphically homogeneous complex Banach manifold. We prove in the first part of the paper that the inclusion of M in T(1) is complex analytic. In the latter portion of this paper it is shown that the unique homogeneous Kaehler metric carried by M = Diff (S 1 )/SL(2, R) induces precisely the Weil-Petersson metric on the Teichmueller space. This is via our identification of M as a holomorphic submanifold of universal Teichmueller space. Now recall that every Teichmueller space T(G) of finite or infinite dimension is contained canonically and holomorphically within T(1). Our computations allow us also to prove that every T(G), G any infinite Fuchsian group, projects out of M transversely. This last assertion is related to the ''fractal'' nature of G-invariant quasicircles, and to Mostow rigidity on the line. Our results thus connect the loop space approach to bosonic string theory with the sumover moduli (Polyakov path integral) approach. (author). 21 refs

Vector-valued Lizorkin-Triebel spaces and sharp trace theory for functions in Sobolev spaces with mixed \\pmb{L_p}-norm for parabolic problems

Science.gov (United States)

Weidemaier, P.

2005-06-01

The trace problem on the hypersurface y_n=0 is investigated for a function u=u(y,t) \\in L_q(0,T;W_{\\underline p}^{\\underline m}(\\mathbb R_+^n)) with \\partial_t u \\in L_q(0,T; L_{\\underline p}(\\mathbb R_+^n)), that is, Sobolev spaces with mixed Lebesgue norm L_{\\underline p,q}(\\mathbb R^n_+\\times(0,T))=L_q(0,T;L_{\\underline p}(\\mathbb R_+^n)) are considered; here \\underline p=(p_1,\\dots,p_n) is a vector and \\mathbb R^n_+=\\mathbb R^{n-1} \\times (0,\\infty). Such function spaces are useful in the context of parabolic equations. They allow, in particular, different exponents of summability in space and time. It is shown that the sharp regularity of the trace in the time variable is characterized by the Lizorkin-Triebel space F_{q,p_n}^{1-1/(p_nm_n)}(0,T;L_{\\widetilde{\\underline p}}(\\mathbb R^{n-1})), \\underline p=(\\widetilde{\\underline p},p_n). A similar result is established for first order spatial derivatives of u. These results allow one to determine the exact spaces for the data in the inhomogeneous Dirichlet and Neumann problems for parabolic equations of the second order if the solution is in the space L_q(0,T; W_p^2(\\Omega)) \\cap W_q^1(0,T;L_p(\\Omega)) with p \\le q.

Derivation of space groups in mm2, 222 and mmm crystal classes

International Nuclear Information System (INIS)

Nigam, G.D.

1987-08-01

An algebraic approach is developed to derive space groups using 4x4 Seitz matrices for the crystal classes mm2, 222 and mmm in the orthorhombic system. The advantage of the present method is that it is relatively simple and can be adapted to introduce space groups to beginners. One of the advantages of the present method is that it admits a geometrical visualization of the symmetry elements of space group. The method can easily be extended to other crystal classes in a straightforward way. 16 refs, 1 fig., 2 tabs

Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population.

Science.gov (United States)

Zhang, Wenjing; Xu, Qun; Zhuang, Yunlong; Chen, Yuanfeng

2016-08-01

Recent studies have reported that the ABO gene can affect circulating expression levels of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble P-selectin (sP-selectin) in Caucasians. However, several factors may affect the association, including the distribution and variations of the ABO gene, ethnic diversity and the inflammatory response status. The aim of the present study was to investigate this issue in Asian subjects of various blood groups. A total of 800 blood samples were randomly selected from healthy blood donors. The ABO blood groups were examined using standard serological tests, and ABO genotypes of group A and group AB specimens were analyzed. Plasma concentrations of sICAM-1 and sP-selectin were detected by standard enzyme-linked immunosorbent assays. In healthy Chinese individuals, blood group A was detected to be significantly associated with lower circulating expression levels of sICAM-1 and sP-selectin, compared with group O. Individuals with ≥1 A1 allele had significantly lower expression levels of sICAM-1 and sP-selectin compared with all other ABO groups. The data indicate the significant association of ABO blood group antigens with sICAM-1 and sP-selectin expression levels in a healthy Chinese population, independent of the specific variations and distributions of ABO blood groups among ethnic populations. This result provides evidence for the previously unidentified role of ABO blood group antigens in the regulation of the inflammatory adhesion process. Accordingly, it can be proposed that ABO blood groups may require consideration when soluble adhesion molecules are identified as predictors for cardiovascular disease.

Some Diophantine equations from finite group theory: $\\Phi_m (x) = 2p^n -1$

NARCIS (Netherlands)

Luca, F.; Moree, P.; Weger, de B.M.M.

2009-01-01

We show that the equation in the title (with Fn the nth cyclotomic polynomial) has no integer solution with n = 1 in the cases (m, p) = (15, 41), (15, 5581), (10, 271). These equations arise in a recent group theoretical investigation by Z. Akhlaghi, M. Khatami and B. Khosravi.

Some Diophantine equations from finite group theory: $\\Phi_m (x) = 2p^n -1$

NARCIS (Netherlands)

Luca, F.; Moree, P.; Weger, de B.M.M.

2011-01-01

We show that the equation in the title (with $\\Psi_m$ the $m$th cyclotomic polynomial) has no integer solution with $n \\geq 1$ in the cases (m,p) = (15,41), (15,5581), (10,271). These equations arise in a recent group theoretical investigation by Akhlaghi, Khosravi and Khatami.

The International Space Life Sciences Strategic Planning Working Group

Science.gov (United States)

White, Ronald J.; Rabin, Robert; Lujan, Barbara F.

1993-01-01

Throughout the 1980s, ESA and the space agencies of Canada, Germany, France, Japan, and the U.S. have pursued cooperative projects bilaterally and multilaterally to prepare for, and to respond to, opportunities in space life sciences research previously unapproachable in scale and sophistication. To cope effectively with likely future space research opportunities, broad, multilateral, coordinated strategic planning is required. Thus, life scientists from these agencies have allied to form the International Space Life Sciences Strategic Planning Working Group. This Group is formally organized under a charter that specifies the purpose of the Working Group as the development of an international strategic plan for the space life sciences, with periodic revisions as needed to keep the plan current. The plan will be policy-, not operations-oriented. The Working Group also may establish specific implementation teams to coordinate multilateral science policy in specific areas; such teams have been established for space station utilization, and for sharing of flight equipment.

Multiloop calculations in p-adic string theory and Bruhat-Tits trees. 1

International Nuclear Information System (INIS)

Zabrodin, A.V.; Mironov, A.D.; Chekhov, L.O.

1989-01-01

The open p-adic string world sheet as a coset space F=T/Γ, where T is the Bruhat-Tits three for the p-adic linear group GL(2.Q p ) and Γ is contained it PGL(2.Q p ) is some Schottky group is treated. The boundary of this world sheet corresponds to p-adic Mumford curve of finite genus. The string dynamics is governed by the local gaussian action on the coset space F. The tachyon amplitudes expressed in terms of p-adic Θ-functions are proposed for the Mumford curve of arbitrary genus and compared them with the corresponding usual archimedian amplitudes. 25 refs.; 5 figs

Automorphisms of p-compact groups and their root data

DEFF Research Database (Denmark)

Andersen, Kasper K. S.; Grodal, Jesper Kragh

2008-01-01

We construct a model for the space of automorphisms of a connected p–compact group in terms of the space of automorphisms of its maximal torus normalizer and its root datum. As a consequence we show that any homomorphism to the outer automorphism group of a p–compact group can be lifted to a group...... action, analogous to   a classical theorem of de Siebenthal for compact Lie groups. The model of this paper is used in a crucial way in our paper `The classification of 2-compact groups' [arXiv:math.AT/0611437], where we prove the conjectured classification of 2–compact groups and determine...... their automorphism spaces....

NASA's Internal Space Weather Working Group

Science.gov (United States)

St. Cyr, O. C.; Guhathakurta, M.; Bell, H.; Niemeyer, L.; Allen, J.

2011-01-01

Measurements from many of NASA's scientific spacecraft are used routinely by space weather forecasters, both in the U.S. and internationally. ACE, SOHO (an ESA/NASA collaboration), STEREO, and SDO provide images and in situ measurements that are assimilated into models and cited in alerts and warnings. A number of years ago, the Space Weather laboratory was established at NASA-Goddard, along with the Community Coordinated Modeling Center. Within that organization, a space weather service center has begun issuing alerts for NASA's operational users. NASA's operational user community includes flight operations for human and robotic explorers; atmospheric drag concerns for low-Earth orbit; interplanetary navigation and communication; and the fleet of unmanned aerial vehicles, high altitude aircraft, and launch vehicles. Over the past three years we have identified internal stakeholders within NASA and formed a Working Group to better coordinate their expertise and their needs. In this presentation we will describe this activity and some of the challenges in forming a diverse working group.

Quantum groups and quantum homogeneous spaces

International Nuclear Information System (INIS)

Kulish, P.P.

1994-01-01

The usefulness of the R-matrix formalism and the reflection equations is demonstrated on examples of the quantum group covariant algebras (quantum homogeneous spaces): quantum Minkowski space-time, quantum sphere and super-sphere. The irreducible representations of some covariant algebras are constructed. The generalization of the reflection equation to super case is given and the existence of the quasiclassical limits is pointed out. (orig.)

Fundamental group of dual graphs and applications to quantum space time

International Nuclear Information System (INIS)

Nada, S.I.; Hamouda, E.H.

2009-01-01

Let G be a connected planar graph with n vertices and m edges. It is known that the fundamental group of G has 1 -(n - m) generators. In this paper, we show that if G is a self-dual graph, then its fundamental group has (n - 1) generators. We indicate that these results are relevant to quantum space time.

Space Interferometry Science Working Group

Science.gov (United States)

Ridgway, Stephen T.

1992-12-01

Decisions taken by the astronomy and astrophysics survey committee and the interferometry panel which lead to the formation of the Space Interferometry Science Working Group (SISWG) are outlined. The SISWG was formed by the NASA astrophysics division to provide scientific and technical input from the community in planning for space interferometry and in support of an Astrometric Interferometry Mission (AIM). The AIM program hopes to measure the positions of astronomical objects with a precision of a few millionths of an arcsecond. The SISWG science and technical teams are described and the outcomes of its first meeting are given.

Effect of the spacer group nature on the optical and electrical properties of confined poly( p-phenylene vinylene) derivatives

Science.gov (United States)

Benzarti-Ghédira, Maha; Zahou, Imen; Hrichi, Haikel; Jaballah, Nejmeddine; Ben Chaâbane, Rafik; Majdoub, Mustapha; Ben Ouada, Hafedh

2015-09-01

This study is an investigation about the effect of chemical modification on the morphological, optical and electrical properties of semiconducting organic thin films. Two confined poly( p-phenylene vinylene) (PPV)-type polymers containing different spacer groups were studied: P1 has an isopropylidene spacer group and P2 with hexafluoroisopropylidene spacer. The UV-Vis absorption and PL analysis showed a stronger π- π interaction in the P1 film; in P2, the π-stacking is limited by the introduction of a bulky trifluoromethyl (CF3) groups on the spacer units. The P2 exhibits a better film quality as illustrated by the atomic force microscopy. The HOMO and LUMO energy levels and electrochemical band gap of the polymers were determinate by the cyclic voltammetry. The electrical properties of ITO/PPV derivative/Al diodes were investigated by means of current-voltage and show a space-charge-limited current conduction mechanism with higher mobility in the P2 thin layer. The impedance spectra of the devices can be discussed in terms of an equivalent circuit model designed as a parallel resistance ( R p) and capacitance ( C p) network in series with a resistance.

On classification of finite groups with four generators, three of which having orders p,p,q (p

International Nuclear Information System (INIS)

Yacoub, K.R.

1984-03-01

Finite groups with two independent generators attracted the attention of authors for several years. The author, having started on such groups in his PhD Thesis in 1953, discussed later on the existence and the structure of finite groups with three generators, one being of arbitrary order and the other two having given orders [Pub. Math. Debrecen, 11, 32-38(1964), 13, 9-16(1966)] and others. Recently, the author started the problem of finite groups with four generators a,b,c and d when b,c and d have the same odd prime order p. It is the object of the present paper to deal with a similar problem when the given orders are p, p and q with p q together with the particular case when m is an element of set containing p,q will be kept to a further discussion. The present paper consists actually of two main parts, the first deals with the case p does not divide q-1 while the second deals with the case p divides q-1. (author)

Symmetries of quantum spaces. Subgroups and quotient spaces of quantum SU(2) and SO(3) groups

International Nuclear Information System (INIS)

Podles, P.

1995-01-01

We prove that each action of a compact matrix quantum group on a compact quantum space can be decomposed into irreducible representations of the group. We give the formula for the corresponding multiplicities in the case of the quotient quantum spaces. We describe the subgroups and the quotient spaces of quantum SU(2) and SO(3) groups. (orig.)

The homology groups of moduli spaces on non-classical Klein surfaces

International Nuclear Information System (INIS)

Zaw, Myint

2001-08-01

We describe the moduli space M-vector±(g,c) of non-classical directed Klein surfaces of genus g=h-c-1 with c≥0 distinguished points as a configuration space B ± (h,c) of classes h-slit pairs in C. Based on this model, we prove that M-vector ± (g,c) is non-orientable for any g and c and we compute the homology groups of the moduli spaces M-vector ± (g,c) for g≤2. (author)

On functional bases of the first-order differential invariants for non-conjugate subgroups of the Poincaré group $P(1,4$

Directory of Open Access Journals (Sweden)

V.M. Fedorchuk

2008-11-01

Full Text Available It is established which functional bases of the first-order differential invariants of the splitting and non-splitting subgroups of the Poincaré group $P(1,4$ are invariant under the subgroups of the extended Galilei group $widetilde G(1,3 subset P(1,4$. The obtained sets of functional bases are classified according to dimensions.

Space dependent neutron slowing and thermalization in monatomic hydrogen gas in the P-1 approximation

International Nuclear Information System (INIS)

Musazay, M.S.

1981-01-01

A solution to the space and energy dependent neutron transport equation in the framework of the consistent P-1 approximation is sought. The transport equation for thermal neutrons in a moderator of 1/v absorption and constant scattering cross section is changed into a set of coupled partial differential equations. The space dependent part is removed by assuming a cosine shaped flux due to a cosine shaped source at a very high energy. The resulting set of strongly coupled ordinary differential equations is decoupled by assuming expansion of collision density in the powers of a leakage parameter whose coefficients are energy and absorption dependent. These energy dependent coefficients are solutions of a set of weakly coupled differential equations. Series solutions to these differential equations in powers of epsilon and 1/epsilon, where epsilon = E/kT, E being the neutron energy and kT the moderator temperature in units of energy, are found. The properties of these solutions are studied extensively. Absorption appears as a parameter in the coefficients of the series. The difficulties arising in choosing the correct form of the asymptotic solutions are resolved by comparing slowing and thermalization. The limitations on the size of the slab and on the range of absorption are included in the analysis

The entire sequence over Musielak p-metric space

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C. Murugesan

2016-04-01

Full Text Available In this paper, we introduce fibonacci numbers of Γ2(F sequence space over p-metric spaces defined by Musielak function and examine some topological properties of the resulting these spaces.

Unitary Representations of Gauge Groups

Science.gov (United States)

Huerfano, Ruth Stella

I generalize to the case of gauge groups over non-trivial principal bundles representations that I. M. Gelfand, M. I. Graev and A. M. Versik constructed for current groups. The gauge group of the principal G-bundle P over M, (G a Lie group with an euclidean structure, M a compact, connected and oriented manifold), as the smooth sections of the associated group bundle is presented and studied in chapter I. Chapter II describes the symmetric algebra associated to a Hilbert space, its Hilbert structure, a convenient exponential and a total set that later play a key role in the construction of the representation. Chapter III is concerned with the calculus needed to make the space of Lie algebra valued 1-forms a Gaussian L^2-space. This is accomplished by studying general projective systems of finitely measurable spaces and the corresponding systems of sigma -additive measures, all of these leading to the description of a promeasure, a concept modeled after Bourbaki and classical measure theory. In the case of a locally convex vector space E, the corresponding Fourier transform, family of characters and the existence of a promeasure for every quadratic form on E^' are established, so the Gaussian L^2-space associated to a real Hilbert space is constructed. Chapter III finishes by exhibiting the explicit Hilbert space isomorphism between the Gaussian L ^2-space associated to a real Hilbert space and the complexification of its symmetric algebra. In chapter IV taking as a Hilbert space H the L^2-space of the Lie algebra valued 1-forms on P, the gauge group acts on the motion group of H defining in an straight forward fashion the representation desired.

Professional Discussion Groups: Informal Learning in a Third Space

Science.gov (United States)

Jordan, Robert A.

2013-01-01

In this ethnographic study, I explored two discussion groups and discovered Third Space elements such as cultural hybridity, counterscript, and sharing of experiences and resources contributed to a safe learning environment existing at the boundaries between participant personal and professional spaces. The groups operated under the auspices of a…

Group theoretical construction of planar noncommutative phase spaces

Energy Technology Data Exchange (ETDEWEB)

Ngendakumana, Ancille, E-mail: nancille@yahoo.fr; Todjihoundé, Leonard, E-mail: leonardt@imsp.uac.org [Institut de Mathématiques et des Sciences Physiques (IMSP), Porto-Novo (Benin); Nzotungicimpaye, Joachim, E-mail: kimpaye@kie.ac.rw [Kigali Institute of Education (KIE), Kigali (Rwanda)

2014-01-15

Noncommutative phase spaces are generated and classified in the framework of centrally extended anisotropic planar kinematical Lie groups as well as in the framework of noncentrally abelian extended planar absolute time Lie groups. Through these constructions the coordinates of the phase spaces do not commute due to the presence of naturally introduced fields giving rise to minimal couplings. By symplectic realizations methods, physical interpretations of generators coming from the obtained structures are given.

Group theoretical construction of planar noncommutative phase spaces

International Nuclear Information System (INIS)

Ngendakumana, Ancille; Todjihoundé, Leonard; Nzotungicimpaye, Joachim

2014-01-01

Noncommutative phase spaces are generated and classified in the framework of centrally extended anisotropic planar kinematical Lie groups as well as in the framework of noncentrally abelian extended planar absolute time Lie groups. Through these constructions the coordinates of the phase spaces do not commute due to the presence of naturally introduced fields giving rise to minimal couplings. By symplectic realizations methods, physical interpretations of generators coming from the obtained structures are given

Normal edge-transitive and $ frac{1}{2}$-arc-transitive Cayley graphs on non-abelian groups of order $2pq$ , $p > q$ are primes

Directory of Open Access Journals (Sweden)

Ali Reza Ashrafi

2016-09-01

Full Text Available Darafsheh and Assari in [Normal edge-transitive Cayley graphs onnon-abelian groups of order 4p, where p is a prime number,Sci. China Math. {bf 56} (1 (2013 213$-$219.] classified the connected normal edge transitive and$frac{1}{2}-$arc-transitive Cayley graph of groups of order$4p$. In this paper we continue this work by classifying theconnected Cayley graph of groups of order $2pq$, $p > q$ areprimes. As a consequence it is proved that $Cay(G,S$ is a$frac{1}{2}-$edge-transitive Cayley graph of order $2pq$, $p> q$ if and only if $|S|$ is an even integer greater than 2, $S =T cup T^{-1}$ and $T subseteq { cba^{i} | 0 leq i leq p- 1}$ such that $T$ and $T^{-1}$ are orbits of $Aut(G,S$ andbegin{eqnarray*}G &=& langle a, b, c | a^p = b^q = c^2 = e, ac = ca, bc = cb, b^{-1}ab = a^r rangle,G &=& langle a, b, c | a^p = b^q = c^2 = e, c ac = a^{-1}, bc = cb, b^{-1}ab = a^r rangle,end{eqnarray*}where $r^q equiv 1 (mod p$.

The pMSSM10 after LHC Run 1

CERN Document Server

de Vries, K.J.; Buchmueller, O.; Cavanaugh, R.; Citron, M.; De Roeck, A.; Dolan, M.J.; Ellis, J.R.; Flächer, H.; Heinemeyer, S.; Isidori, G.; Malik, S.; Marrouche, J.; Martinez Santos, D.; Olive, K.A.; Sakurai, K.; Weiglein, G.

2015-01-01

We present a frequentist analysis of the parameter space of the pMSSM10, in which the following 10 soft SUSY-breaking parameters are specified independently at the mean scalar top mass scale Msusy = Sqrt[M_stop1 M_stop2]: the gaugino masses M_{1,2,3}, the 1st-and 2nd-generation squark masses M_squ1 = M_squ2, the third-generation squark mass M_squ3, a common slepton mass M_slep and a common trilinear mixing parameter A, the Higgs mixing parameter mu, the pseudoscalar Higgs mass M_A and tan beta. We use the MultiNest sampling algorithm with 1.2 x 10^9 points to sample the pMSSM10 parameter space. A dedicated study shows that the sensitivities to strongly-interacting SUSY masses of ATLAS and CMS searches for jets, leptons + MET signals depend only weakly on many of the other pMSSM10 parameters. With the aid of the Atom and Scorpion codes, we also implement the LHC searches for EW-interacting sparticles and light stops, so as to confront the pMSSM10 parameter space with all relevant SUSY searches. In addition, ou...

7 CFR 29.1166 - Primings (P Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Primings (P Group). 29.1166 Section 29.1166... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.1166 Primings (P Group). This group consists of round-tipped leaves from the lowest portion of the stalk. Leaves of the P group ripen prematurely as a result...

Optical Fiber Assemblies for Space Flight from the NASA Goddard Space Flight Center, Photonics Group

Science.gov (United States)

Ott, Melanie N.; Thoma, William Joe; LaRocca, Frank; Chuska, Richard; Switzer, Robert; Day, Lance

2009-01-01

The Photonics Group at NASA Goddard Space Flight Center in the Electrical Engineering Division of the Advanced Engineering and Technologies Directorate has been involved in the design, development, characterization, qualification, manufacturing, integration and anomaly analysis of optical fiber subsystems for over a decade. The group supports a variety of instrumentation across NASA and outside entities that build flight systems. Among the projects currently supported are: The Lunar Reconnaissance Orbiter, the Mars Science Laboratory, the James Webb Space Telescope, the Express Logistics Carrier for the International Space Station and the NASA Electronic Parts. and Packaging Program. A collection of the most pertinent information gathered during project support over the past year in regards to space flight performance of optical fiber components is presented here. The objective is to provide guidance for future space flight designs of instrumentation and communication systems.

Evaluation of the effects of subgingival injection of Simvastatin on space re-opening after orthodontic space closure in adults

Directory of Open Access Journals (Sweden)

Arezoo Jahanbin

2016-03-01

Full Text Available Background. This clinical trial evaluated the effect of Simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (GI and clinical attachment loss (CAL. Methods. 16 females, 25‒40 years old, with spaces between anterior mandibular teeth due to chronic periodontitis were participated in this study. The patients were randomly divided into control and experimental groups. In the experimental group, 1.2% Simvastatin gel and in the control group, 0.9% sodium chloride as a placebo was injected into the pocket depth of the six anterior teeth. The amount of space reopening, GI and CAL were measured. Results. No serious complications were observed during interventions and follow-up periods. Space re-opening was significantly reduced in patients receiving Simvastatin (P < 0.001. Moreover, GI reduction was significantly greater in Sim-vastatin group compared to the control group (P < 0.001. However, CAL did not demonstrate a significant difference between the groups. Conclusion. Simvastatin may decrease space re-opening after orthodontic space closure in human anterior teeth.

Non-Supramenable Groups Acting on Locally Compact Spaces

DEFF Research Database (Denmark)

Kellerhals, Julian; Monod, Nicolas; Rørdam, Mikael

2013-01-01

Supramenability of groups is characterised in terms of invariant measures on locally compact spaces. This opens the door to constructing interesting crossed product $C^*$-algebras for non-supramenable groups. In particular, stable Kirchberg algebras in the UCT class are constructed using crossed ...

BAYESZ, S-Wave, P-Wave Resonance Level Spacing and Strength Functions

International Nuclear Information System (INIS)

Moore, M.S.

1982-01-01

A - Description of problem or function: BAYESZ calculates average s- and p-wave level spacings, strength functions, and average radiation widths of a mixed sequence of s- and p-wave resonances whose parameters are supplied as input. The code is based on two physical assumptions: 1) The neutron reduced width distribution for each open channel is a chi-squared distribution with one degree of freedom, i.e. Porter-Thomas. 2) The spacing distribution follows the Gaussian Orthogonal Ensemble. This property is used, however, only to fix the s- to p-wave level density ratio as proportional to (2J+1) with a spin cut-off correction. B - Method of solution: The method used is an extension of that described by Moore et al. in reference (1), and is based on the method of moments of a truncated Porter-Thomas distribution. C - Restrictions on the complexity of the problem: Parameters for a maximum of 500 individual resonances can be specified. This restriction can be relaxed by increasing array dimensions

Working Group 2 summary: Space charge effects in bending systems

International Nuclear Information System (INIS)

Bohn, C.L.; Emma, P.J.

2000-01-01

At the start of the Workshop, the authors asked the Working Group 2 participants to concentrate on three basic goals: (1) survey the status of how comprehensively the physics concerning space-charge effects in bends is understood and how complete is the available ensemble of analytic and computational tools; (2) guided by data from experiments and operational experience, identify sources of, and cures for, beam degradation; and (3) review space-charge physics in rings and the limitations it introduces. As the Workshop unfolded, the third goal naturally folded into the other two goals, and these goals, they believe, were fulfilled in that the Working Group was able to compile an end product consisting of a set of recommendations for potentially fruitful future work. This summary constitutes an overview of the deliberations of the Working Group, and it is their hope that the summary clarifies the motivation for the recommended work listed at the end. The summary is organized according to the two aforementioned goals, and the prime topics of discussion appear as subsections under these goals

Phase equilibria in the Mo-Fe-P system at 800 °C and structure of ternary phosphide (Mo(1-x)Fe(x))3P (0.10 ≤ x ≤ 0.15).

Science.gov (United States)

Oliynyk, Anton O; Lomnytska, Yaroslava F; Dzevenko, Mariya V; Stoyko, Stanislav S; Mar, Arthur

2013-01-18

Construction of the isothermal section in the metal-rich portion (ternary phases: (Mo(1-x)Fe(x))(2)P (x = 0.30-0.82) and (Mo(1-x)Fe(x))(3)P (x = 0.10-0.15). The occurrence of a Co(2)Si-type ternary phase (Mo(1-x)Fe(x))(2)P, which straddles the equiatomic composition MoFeP, is common to other ternary transition-metal phosphide systems. However, the ternary phase (Mo(1-x)Fe(x))(3)P is unusual because it is distinct from the binary phase Mo(3)P, notwithstanding their similar compositions and structures. The relationship has been clarified through single-crystal X-ray diffraction studies on Mo(3)P (α-V(3)S-type, space group I42m, a = 9.7925(11) Å, c = 4.8246(6) Å) and (Mo(0.85)Fe(0.15))(3)P (Ni(3)P-type, space group I4, a = 9.6982(8) Å, c = 4.7590(4) Å) at -100 °C. Representation in terms of nets containing fused triangles provides a pathway to transform these closely related structures through twisting. Band structure calculations support the adoption of these structure types and the site preference of Fe atoms. Electrical resistivity measurements on (Mo(0.85)Fe(0.15))(3)P reveal metallic behavior but no superconducting transition.

Blood Group Antigens C, Lub and P1 May Have a Role in HIV Infection in Africans.

Science.gov (United States)

Motswaledi, Modisa Sekhamo; Kasvosve, Ishmael; Oguntibeju, Oluwafemi Omoniyi

2016-01-01

Botswana is among the world's countries with the highest rates of HIV infection. It is not known whether or not this susceptibility to infection is due to genetic factors in the population. Accumulating evidence, however, points to the role of erythrocytes as potential mediators of infection. We therefore sought to establish the role, if any, of some erythrocyte antigens in HIV infection in a cross-section of the population. 348 (346 HIV-negative and 2 HIV-positive) samples were obtained from the National Blood Transfusion Service as residual samples, while 194 HIV-positive samples were obtained from the Botswana-Harvard HIV Reference Laboratory. Samples were grouped for twenty three antigens. Chi-square or Fischer Exact analyses were used to compare the frequencies of the antigens in the two groups. A stepwise, binary logistic regression was used to study the interaction of the various antigens in the light of HIV-status. The Rh antigens C and E were associated with HIV-negative status, while blood group Jka, P1 and Lub were associated with HIV-positive status. A stepwise binary logistic regression analysis yielded group C as the most significant protective blood group while Lub and P1 were associated with significantly higher odds ratio in favor of HIV-infection. The lower-risk-associated group C was significantly lower in Africans compared to published data for Caucasians and might partially explain the difference in susceptibility to HIV-1. The most influential antigen C, which also appears to be protective, is significantly lower in Africans than published data for Caucasians or Asians. On the other hand, there appear to be multiple antigens associated with increased risk that may override the protective role of C. A study of the distribution of these antigens in other populations may shed light on their roles in the HIV pandemic.

The birth of NASA the work of the Space Task Group, America's first true space pioneers

CERN Document Server

von Ehrenfried, Dutch

2016-01-01

This is the story of the work of the original NASA space pioneers; men and women who were suddenly organized in 1958 from the then National Advisory Committee on Aeronautics (NACA) into the Space Task Group. A relatively small group, they developed the initial mission concept plans and procedures for the U. S. space program. Then they boldly built hardware and facilities to accomplish those missions. The group existed only three years before they were transferred to the Manned Spacecraft Center in Houston, Texas, in 1962, but their organization left a large mark on what would follow. Von Ehrenfried's personal experience with the STG at Langley uniquely positions him to describe the way the group was structured and how it reacted to the new demands of a post-Sputnik era. He artfully analyzes how the growing space program was managed and what techniques enabled it to develop so quickly from an operations perspective. The result is a fascinating window into history, amply backed up by first person documentation ...

El Naschie's Cantorian space-time and general relativity by means of Barbilian's group. A Cantorian fractal axiomatic model of space-time

International Nuclear Information System (INIS)

Gottlieb, I.; Agop, M.; Jarcau, M.

2004-01-01

One builds the vacuum metrics of the stationary electromagnetic field through the complex potential model. There are thus emphasized both a variational principle, independent on the Ricci tensor, and some internal symmetries of the vacuum solutions. One shows that similar results may be obtained using the Barbiliant's group. By analytical continuation of a Barbilian transformation the link between the fixed points of the modular groups of the vacuum and the golden mean PHI=(1/(1+PHI))=(√5-1)/2 of ε (∞) space-time is established. Finally, a Cantorian fractal axiomatic model of the space-time is presented. The model is explained using a set of coupled equations which may describe the self organizing processes at the solid-liquid, plasma-plasma, and superconductor-superconductor interfaces

Projective unitary-antiunitary representations of the Shubnikov space groups

International Nuclear Information System (INIS)

Broek, P.M. van den.

1979-01-01

Some mathematical aspects of the symmetry of a physical system in quantum mechanics are examined with special emphasis on the symmetry groups of charged particles in crystalline solids, the Shuknikov space groups. (Auth.)

Magnetocaloric effects in Mn1.35Fe0.65P1−xSix compounds

International Nuclear Information System (INIS)

Geng Yao-Xiang; Tegus O; Bi Li-Ge

2012-01-01

The structural and magnetocaloric properties of Mn 1.35 Fe 0.65 P 1−x Si x compounds are investigated. The Si-substituted compounds, Mn 1.35 Fe 0.65 P 1−x Si x with x = 0.52, 0.54, 0.55, 0.56, and 0.57, are prepared by high-energy ball milling and the solid-state reaction. The X-ray diffraction shows that the compounds crystallize into the Fe 2 P-type hexagonal structure with space group P6-bar2m. The magnetic measurements show that the Curie temperature of the compound increases from 253 K for x = 0.52 to 296 K for x = 0.56. The isothermal magnetic-entropy change of the Mn 1.35 Fe 0.65 P 1−x Si x compound decreases with the Si content increasing. The maximal value of the magnetic-entropy change is about 7.0 J/kg·K in the Mn 1.35 Fe 0.65 P 0.48 Si 0.52 compound with a field change of 1.5 T. The compound quenched in water possesses a larger magnetic entropy change and a smaller thermal hysteresis than the non-quenched samples. The thermal hysteresis of the compound is less than 3.5 K. The maximum adiabatic temperature change is about 1.4 K in the Mn 1.35 Fe 0.65 P 0.45 Si 0.55 compound with a field change of 1.48 T. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

Contribution of on-site Coulomb repulsion energy to structural, electronic and magnetic properties of SrCoO3 for different space groups: first-principles study

Directory of Open Access Journals (Sweden)

Muhammady Shibghatullah

2018-03-01

Full Text Available We report structural, electronic, and magnetic properties of SrCoO3 in Pm3̅m and P4/mbm space groups, which are calculated by using generalized gradient approximation corrected with on-site Coulomb repulsion U and exchange energies J. The cubic lattice parameter a and local magnetic moments of Co (μCo are optimized by varying U at Co 3d site. Employing ultrasoft pseudopotential, the values of U = 8 eV and J = 0.75 eV are the best choice for Pm3̅m space group. We found the value of μCo = 2.56 μB, which is consistent with the previous results. It was also found that Co 3d, hybridized with O 2p, is the main contributor to ferromagnetic metallic properties. Besides, norm-conserving pseudopotential promotes a, which is in good agreement with experimental result. However, it is not suitable for P4/mbm space group. By using ultrasoft pseudopotential, the value of U = 3 eV (J = 0.75 is the most suitable for P4/mbm group. Ferromagnetic metallic properties, Jahn-Teller distortion, and reasonable lattice parameters have been obtained. This study shows that U has significant contribution to the calculated properties and also points out that P4/mbm space group with US-PP is suitable to describe experimental results.

Functional characterization of replication and stability factors of an incompatibility group P-1 plasmid from Xylella fastidiosa.

Science.gov (United States)

Lee, Min Woo; Rogers, Elizabeth E; Stenger, Drake C

2010-12-01

Xylella fastidiosa strain riv11 harbors a 25-kbp plasmid (pXF-RIV11) belonging to the IncP-1 incompatibility group. Replication and stability factors of pXF-RIV11 were identified and used to construct plasmids able to replicate in X. fastidiosa and Escherichia coli. Replication in X. fastidiosa required a 1.4-kbp region from pXF-RIV11 containing a replication initiation gene (trfA) and the adjacent origin of DNA replication (oriV). Constructs containing trfA and oriV from pVEIS01, a related IncP-1 plasmid of the earthworm symbiont Verminephrobacter eiseniae, also were competent for replication in X. fastidiosa. Constructs derived from pXF-RIV11 but not pVEIS01 replicated in Agrobacterium tumefaciens, Xanthomonas campestris, and Pseudomonas syringae. Although plasmids bearing replication elements from pXF-RIV11 or pVEIS01 could be maintained in X. fastidiosa under antibiotic selection, removal of selection resulted in plasmid extinction after 3 weekly passages. Addition of a toxin-antitoxin addiction system (pemI/pemK) from pXF-RIV11 improved plasmid stability such that >80 to 90% of X. fastidiosa cells retained plasmid after 5 weekly passages in the absence of antibiotic selection. Expression of PemK in E. coli was toxic for cell growth, but toxicity was nullified by coexpression of PemI antitoxin. Deletion of N-terminal sequences of PemK containing the conserved motif RGD abolished toxicity. In vitro assays revealed a direct interaction of PemI with PemK, suggesting that antitoxin activity of PemI is mediated by toxin sequestration. IncP-1 plasmid replication and stability factors were added to an E. coli cloning vector to constitute a stable 6.0-kbp shuttle vector (pXF20-PEMIK) suitable for use in X. fastidiosa.

Rhodium-Catalyzed Insertion Reaction of PhP Group of Pentaphenylcyclopentaphosphine with Acyclic and Cyclic Disulfides.

Science.gov (United States)

Arisawa, Mieko; Sawahata, Kyosuke; Yamada, Tomoki; Sarkar, Debayan; Yamaguchi, Masahiko

2018-02-16

Organophosphorus compounds with a phosphorus atom attached to a phenyl group and two organothio/organoseleno groups were synthesized using the rhodium-catalyzed insertion reaction of the PhP group of pentaphenylcyclopentaphosphine (PhP) 5 with acyclic disulfides and diselenides. The method was applied to the synthesis of heterocyclic compounds containing the S-P-S group by the reaction of (PhP) 5 and cyclic disulfides such as 1,2-dithietes, 1,2-dithiocane, 1,4,5-dithiopane, and 1,2-dithiolanes.

Canonical Groups for Quantization on the Two-Dimensional Sphere and One-Dimensional Complex Projective Space

International Nuclear Information System (INIS)

Sumadi A H A; H, Zainuddin

2014-01-01

Using Isham's group-theoretic quantization scheme, we construct the canonical groups of the systems on the two-dimensional sphere and one-dimensional complex projective space, which are homeomorphic. In the first case, we take SO(3) as the natural canonical Lie group of rotations of the two-sphere and find all the possible Hamiltonian vector fields, and followed by verifying the commutator and Poisson bracket algebra correspondences with the Lie algebra of the group. In the second case, the same technique is resumed to define the Lie group, in this case SU (2), of CP'.We show that one can simply use a coordinate transformation from S 2 to CP 1 to obtain all the Hamiltonian vector fields of CP 1 . We explicitly show that the Lie algebra structures of both canonical groups are locally homomorphic. On the other hand, globally their corresponding canonical groups are acting on different geometries, the latter of which is almost complex. Thus the canonical group for CP 1 is the double-covering group of SO(3), namely SU(2). The relevance of the proposed formalism is to understand the idea of CP 1 as a space of where the qubit lives which is known as a Bloch sphere

Student "Facebook" Groups as a Third Space: Between Social Life and Schoolwork

Science.gov (United States)

Aaen, Janus; Dalsgaard, Christian

2016-01-01

The paper examines educational potentials of "Facebook" groups that are created and managed by students without any involvement from teachers. The objective is to study student-managed "Facebook" groups as a "third space" between the institutional space of teacher-managed "Facebook" groups and the…

Renormalization group in statistical physics - momentum and real spaces

International Nuclear Information System (INIS)

Yukalov, V.I.

1988-01-01

Two variants of the renormalization group approach in statistical physics are considered, the renormalization group in the momentum and the renormalization group in the real spaces. Common properties of these methods and their differences are cleared up. A simple model for investigating the crossover between different universality classes is suggested. 27 refs

P-adic space-time and string theory

International Nuclear Information System (INIS)

Volovich, I.V.

1987-01-01

Arguments for the possibility of a p-adic structure of space-time are advanced. The p-adic analog of the Veneziano amplitude is proposed, and this permits a start to be made on the construction of the theory of p-adic strings. The same questions are considered over Galois fields, for which the analog of the Veneziano amplitude is a Jacobi sum that can be expressed in terms of p-adic cohomologies of Fermat curves. An explicit expression for the vertex operator of the corresponding string theory is given

Triple-axis X-ray reciprocal space mapping of In{sub y}Ga{sub 1-y}As thermophotovoltaic diodes grown on (1 0 0) InP substrates

Energy Technology Data Exchange (ETDEWEB)

Dashiell, M.W.; Ehsani, H.; Sander, P.C. [Lockheed Martin Corporation, Schenectady, NY 12301-1072 (United States); Newman, F.D. [Emcore Corporation, Albuquerque, NM 87123 (United States); Wang, C.A. [MIT Lincoln Laboratory, Lexington, MA 02420 (United States); Shellenbarger, Z.A. [Sarnoff Corporation, Princeton NJ, 08543-5300 (United States); Donetski, D.; Gu, N.; Anikeev, S. [Department of Electrical Engineering, State University of New York, Stony Brook, NY 11794-2350 (United States)

2008-09-15

Analysis of the composition, strain-relaxation, layer-tilt, and the crystalline quality of In{sub y}Ga{sub 1-y}As/InP{sub 1-x}As{sub x} thermophotovoltaic (TPV) diodes grown by metal-organic vapor phase epitaxy (MOVPE) is demonstrated using triple-axis X-ray reciprocal space mapping techniques. In{sub 0.53}Ga{sub 0.47}As (E{sub gap}=0.74 eV) n/p junction diodes are grown lattice matched (LM) to InP substrates and lattice-mismatched (LMM) In{sub 0.67}Ga{sub 0.33}As (E{sub gap}=0.6 eV) TPV diodes are grown on three-step InP{sub 1-x}As{sub x} (0P substrates. X-ray reciprocal space maps about the symmetric (4 0 0) and asymmetric (5 3 3) reciprocal lattice points (RELPs) determine the in-plane and out-of-plane lattice parameters and strain of the In{sub y}Ga{sub 1-y}As TPV active layer and underlying InP{sub 1-x}As{sub x} buffers. Triple-axis X-ray rocking curves about the LMM In{sub 0.67}Ga{sub 0.33}As RELP show an order of magnitude increase of its full-width at half-maximum (FWHM) compared to that from the LM In{sub 0.53}Ga{sub 0.47}As (250 vs. 30 arcsec). Despite the significant RELP broadening, the photovoltaic figure of merits show that the electronic quality of the LMM In{sub 0.67}Ga{sub 0.33}As approaches that of the LM diode material. This indicates that misfit-related crystalline imperfections are not dominating the photovoltaic response of the optimized LMM In{sub 0.67}Ga{sub 0.33}As material compared with the intrinsic recombination processes and/or recombination through native point defects, which would be present in both LMM and LM diode material. However, additional RELP broadening in non-optimized LMM In{sub 0.67}Ga{sub 0.33}As n/p junction diodes does correspond to significant degradation of TPV diode open-circuit voltage and minority carrier lifetime demonstrating that there is correlation between X-ray FWHM and the electronic performance of the LMM TPV diodes. (author)

Some p-ranks related to orthogonal spaces

NARCIS (Netherlands)

Blokhuis, A.; Moorhouse, G.E.

1995-01-01

We determine the p-rank of the incidence matrix of hyperplanes of PG(n, p e) and points of a nondegenerate quadric. This yields new bounds for ovoids and the size of caps in finite orthogonal spaces. In particular, we show the nonexistence of ovoids in O10+ (2e ),O10+ (3e ),O9 (5e ),O12+ (5e

The pMSSM10 after LHC Run 1

International Nuclear Information System (INIS)

De Vries, K.J.; Buchmueller, O.

2015-04-01

We present a frequentist analysis of the parameter space of the pMSSM10, in which the following 10 soft SUSY-breaking parameters are specified independently at the mean scalar top mass scale M SUSY ≡√(m t 1 m t 2 ): the gaugino masses M 1,2,3 , the 1st-and 2nd-generation squark masses m q 1 =m q 2 , the third-generation squark mass m q 3 , a common slepton mass M l and a common trilinear mixing parameter A, the Higgs mixing parameter μ, the pseudoscalar Higgs mass M A and tan β. We use the MultiNest sampling algorithm with ∝1.2 x 10 9 points to sample the pMSSM10 parameter space. A dedicated study shows that the sensitivities to strongly-interacting SUSY masses of ATLAS and CMS searches for jets, leptons+E T signals depend only weakly on many of the other pMSSM10 parameters. With the aid of the Atom and Scorpion codes, we also implement the LHC searches for EW-interacting sparticles and light stops, so as to confront the pMSSM10 parameter space with all relevant SUSY searches. In addition, our analysis includes Higgs mass and rate measurements using the HiggsSignals code, SUSY Higgs exclusion bounds, the measurements B-physics observables, EW precision observables, the CDM density and searches for spin-independent DM scattering. We show that the pMSSM10 is able to provide a SUSY interpretation of (g-2) μ , unlike the CMSSM, NUHM1 and NUHM2. As a result, we find (omitting Higgs rates) that the minimum χ 2 /d.o.f.=20.5/18 in the pMSSM10, corresponding to a χ 2 probability of 30.8 %, to be compared with χ 2 /d.o.f.=32.8/24(31.1/23)(30.3/22) in the CMSSM (NUHM1) (NUHM2). We display 1-dimensional likelihood functions for SUSY masses, and show that they may be significantly lighter in the pMSSM10 than in the CMSSM, NUHM1 and NUHM2. We discuss the discovery potential of future LHC runs, e + e - colliders and direct detection experiments.

Groups, matrices, and vector spaces a group theoretic approach to linear algebra

CERN Document Server

Carrell, James B

2017-01-01

This unique text provides a geometric approach to group theory and linear algebra, bringing to light the interesting ways in which these subjects interact. Requiring few prerequisites beyond understanding the notion of a proof, the text aims to give students a strong foundation in both geometry and algebra. Starting with preliminaries (relations, elementary combinatorics, and induction), the book then proceeds to the core topics: the elements of the theory of groups and fields (Lagrange's Theorem, cosets, the complex numbers and the prime fields), matrix theory and matrix groups, determinants, vector spaces, linear mappings, eigentheory and diagonalization, Jordan decomposition and normal form, normal matrices, and quadratic forms. The final two chapters consist of a more intensive look at group theory, emphasizing orbit stabilizer methods, and an introduction to linear algebraic groups, which enriches the notion of a matrix group. Applications involving symm etry groups, determinants, linear coding theory ...

Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity

International Nuclear Information System (INIS)

Pannucci, N L; Li, D; Sahay, S; Thomas, E K; Chen, R; Tala, I; Hu, T; Ciccarelli, B T; Megjugorac, N J; Adams III, H C; Rodriguez, P L; Fitzpatrick, E R; Lagunoff, D; Williams, D A; Whitehead, I P

2013-01-01

Previous studies have demonstrated that p210 BCR/ABL1 interacts directly with the xeroderma pigmentosum group B (XPB) protein, and that XPB is phosphorylated on tyrosine in cells that express p210 BCR/ABL1. In the current study, we have constructed a p210 BCR/ABL1 mutant that can no longer bind to XPB. The mutant has normal kinase activity and interacts with GRB2, but can no longer phosphorylate XPB. Loss of XPB binding is associated with reduced expression of c-MYC and reduced transforming potential in ex-vivo clonogenicity assays, but does not affect nucleotide excision repair in lymphoid or myeloid cells. When examined in a bone marrow transplantation (BMT) model for chronic myelogenous leukemia, mice that express the mutant exhibit attenuated myeloproliferation and lymphoproliferation when compared with mice that express unmodified p210 BCR/ABL1. Thus, the mutant-transplanted mice show predominantly neutrophilic expansion and altered progenitor expansion, and have significantly extended lifespans. This was confirmed in a BMT model for B-cell acute lymphoblastic leukemia, wherein the majority of the mutant-transplanted mice remain disease free. These results suggest that the interaction between p210 BCR/ABL1 and XPB can contribute to disease progression by influencing the lineage commitment of lymphoid and myeloid progenitors

Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria

DEFF Research Database (Denmark)

Magistrado, Pamela A; Lusingu, John; Vestergaard, Lasse S

2007-01-01

where P. falciparum is endemic, parasites causing severe malaria and malaria in young children with limited immunity tend to express semiconserved PfEMP1 molecules encoded by group A var genes. Here we investigated antibody responses of Tanzanians who were 0 to 19 years old to PF11_0008, a group A Pf...

Real space renormalization group for spectra and density of states

International Nuclear Information System (INIS)

Wiecko, C.; Roman, E.

1984-09-01

We discuss the implementation of the Real Space Renormalization Group Decimation Technique for 1-d tight-binding models with long range interactions with or without disorder and for the 2-d regular square lattice. The procedure follows the ideas developed by Southern et al. Some new explicit formulae are included. The purpose of this study is to calculate spectra and densities of states following the procedure developed in our previous work. (author)

A Phase Transformation with no Change in Space Group Symmetry: Octafluoronaphtalene

DEFF Research Database (Denmark)

Pawley, G. S.; Dietrich, O. W.

1975-01-01

A solid-state phase transformation in octafluoronaphthalene has been discovered at 266.5K on cooling, and at 15K higher on heating. The symmetry of both phases is found to be the same, namely monoclinic with space group P21/c. The unit cell parameters change by up to 10%, but the integrity...... of a single crystal, which shatters on cooling, is good enough for a single-crystal structure determination. This has been done in both phases to a sufficient accuracy that a mechanism for the transformation can be proposed. Molecules which lie parallel to one another shear to a new parallel position...

System theory on group manifolds and coset spaces.

Science.gov (United States)

Brockett, R. W.

1972-01-01

The purpose of this paper is to study questions regarding controllability, observability, and realization theory for a particular class of systems for which the state space is a differentiable manifold which is simultaneously a group or, more generally, a coset space. We show that it is possible to give rather explicit expressions for the reachable set and the set of indistinguishable states in the case of autonomous systems. We also establish a type of state space isomorphism theorem. Our objective is to reduce all questions about the system to questions about Lie algebras generated from the coefficient matrices entering in the description of the system and in that way arrive at conditions which are easily visualized and tested.

Expression, crystallization and preliminary crystallographic analysis of the extracellular IgV-like domain of the human natural killer cell inhibitory receptor p75/AIRM1.

Science.gov (United States)

Dimasi, Nazzareno; Moretta, Lorenzo; Biassoni, Roberto; Mariuzza, Roy A

2003-10-01

p75/AIRM1 (Siglec-7) is a sialic acid-binding Ig-like lectin recently identified as an inhibitory receptor on natural killer cells. The expression, in vitro folding, circular-dichroism spectroscopy, crystallization and preliminary X-ray characterization of the Ig-V like domain of p75/AIRM1 are reported. X-ray data were collected from a single crystal at 100 K, with a maximum useful diffraction pattern extending to 1.45 A resolution on a synchrotron source. The crystal belongs to a primitive monoclinic space group, with unit-cell parameters a = 32.65, b = 49.72, c = 39.79 A, alpha = gamma = 90, beta = 113 degrees. The systematic absences indicate that the space group is P2(1). Assuming one molecule per asymmetric unit, V(M) (the Matthews coefficient) was calculated to be 1.879 A(3) Da(-1) and the solvent content was estimated to be 32.01%.

Experimentally verifiable Yang-Mills spin 2 gauge theory of gravity with group U(1) x SU(2)

International Nuclear Information System (INIS)

Peng, H.

1988-01-01

In this work, a Yang-Mills spin 2 gauge theory of gravity is proposed. Based on both the verification of the helicity 2 property of the SU(2) gauge bosons of the theory and the agreement of the theory with most observational and experimental evidence, the authors argues that the theory is truly a gravitational theory. An internal symmetry group, the eigenvalues of its generators are identical with quantum numbers, characterizes the interactions of a given class. The author demonstrates that the 4-momentum P μ of a fermion field generates the U(1) x SU(2) internal symmetry group for gravity, but not the transformation group T 4 . That particles are classified by mass and spin implies that the U(1) x SU(2), instead of the Poincare group, is a symmetry group of gravity. It is shown that the U(1) x SU(2) group represents the time displacement and rotation in ordinary space. Thereby internal space associated with gravity is identical with Minkowski spacetime, so a gauge potential of gravity carries two space-time indices. Then he verifies that the SU(2) gravitational boson has helicity 2. It is this fact, spin from internal spin, that explains alternatively why the gravitational field is the only field which is characterized by spin 2. The Physical meaning of gauge potentials of gravity is determined by comparing theory with the results of experiments, such as the Collella-Overhauser-Werner (COW) experiment and the Newtonian limit, etc. The gauge potentials this must identify with ordinary gravitational potentials

Path integral for coherent states of the dynamical U2 group and U2/1 supergroup

International Nuclear Information System (INIS)

Kochetov, E.A.

1992-01-01

A part-integral formulation in the representation of coherent states for the unitary U 2 group and U 2/1 supergroup is introduced. U 2 and U 2/1 path integrals are shown to be defined on the coset spaces U 2 /U 1 xU 1 and U 2/1 /U 1/1 xU 1 , respectively. These coset appears as curved classical phase spaces. Partition functions are expressed as path integrals over these spaces. In the case when U 2 and U 2/1 are the dynamical groups, the corresponding path integrals are evaluated with the help of linear fractional transformations that appear as the group (supergroup) action in the coset space (superspace). Possible applications for quantum models are discussed. 9 refs

METHOD OF GROUP OBJECTS FORMING FOR SPACE-BASED REMOTE SENSING OF THE EARTH

Directory of Open Access Journals (Sweden)

A. N. Grigoriev

2015-07-01

Full Text Available Subject of Research. Research findings of the specific application of space-based optical-electronic and radar means for the Earth remote sensing are considered. The subject matter of the study is the current planning of objects survey on the underlying surface in order to increase the effectiveness of sensing system due to the rational use of its resources. Method. New concept of a group object, stochastic swath and stochastic length of the route is introduced. The overview of models for single, group objects and their parameters is given. The criterion for the existence of the group object based on two single objects is formulated. The method for group objects formation while current survey planning has been developed and its description is presented. The method comprises several processing stages for data about objects with the calculation of new parameters, the stochastic characteristics of space means and validates the spatial size of the object value of the stochastic swath and stochastic length of the route. The strict mathematical description of techniques for model creation of a group object based on data about a single object and onboard special complex facilities in difficult conditions of registration of spatial data is given. Main Results. The developed method is implemented on the basis of modern geographic information system in the form of a software tool layout with advanced tools of processing and analysis of spatial data in vector format. Experimental studies of the forming method for the group of objects were carried out on a different real object environment using the parameters of modern national systems of the Earth remote sensing detailed observation Canopus-B and Resurs-P. Practical Relevance. The proposed models and method are focused on practical implementation using vector spatial data models and modern geoinformation technologies. Practical value lies in the reduction in the amount of consumable resources by means of

Differential calculus on quantum spaces and quantum groups

International Nuclear Information System (INIS)

Zumino, B.

1992-01-01

A review of recent developments in the quantum differential calculus. The quantum group GL q (n) is treated by considering it as a particular quantum space. Functions on SL q (n) are defined as a subclass of functions on GL q (n). The case of SO q (n) is also briefly considered. These notes cover part of a lecture given at the XIX International Conference on Group Theoretic Methods in Physics, Salamanca, Spain 1992

The crystallographic space groups and Heterotic string theory

International Nuclear Information System (INIS)

El Naschie, M.S.

2009-01-01

While the 17 planar crystallographic groups were shown to correspond to 17 two and three Stein spaces with a total dimension equal to DimE12=5α-bar o ≅685, the present work reveals that the corresponding 219 three dimensional groups leads to a total dimensionality equal to N o ≅8872 which happens to be the exact total number of massless states of the transfinite version of Heterotic super string spectrum.

Pancreas of C57 black mice after long-term space flight (Bion-M1 Space Mission).

Science.gov (United States)

Proshchina, A E; Krivova, Y S; Saveliev, S C

2015-11-01

In this study, we analysed the pancreases of C57BL/6N mice in order to estimate the effects of long-term space flights. Mice were flown aboard the Bion-M1 biosatellite, or remained on ground in the control experiment that replicated environmental and housing conditions in the spacecraft. Vivarium control group was used to account for housing effects. Each of the groups included mice designated for recovery studies. Mice pancreases were dissected for histological and immunohistochemical examinations. Using a morphometry and statistical analysis, a strong correlation between the mean islet size and the mean body weight was revealed in all groups. Therefore, we propose that hypokinesia and an increase in nutrition play an important role in alterations of the endocrine pancreas, both in space flight and terrestrial conditions. Copyright © 2015 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.

Grouped fuzzy SVM with EM-based partition of sample space for clustered microcalcification detection.

Science.gov (United States)

Wang, Huiya; Feng, Jun; Wang, Hongyu

2017-07-20

Detection of clustered microcalcification (MC) from mammograms plays essential roles in computer-aided diagnosis for early stage breast cancer. To tackle problems associated with the diversity of data structures of MC lesions and the variability of normal breast tissues, multi-pattern sample space learning is required. In this paper, a novel grouped fuzzy Support Vector Machine (SVM) algorithm with sample space partition based on Expectation-Maximization (EM) (called G-FSVM) is proposed for clustered MC detection. The diversified pattern of training data is partitioned into several groups based on EM algorithm. Then a series of fuzzy SVM are integrated for classification with each group of samples from the MC lesions and normal breast tissues. From DDSM database, a total of 1,064 suspicious regions are selected from 239 mammography, and the measurement of Accuracy, True Positive Rate (TPR), False Positive Rate (FPR) and EVL = TPR* 1-FPR are 0.82, 0.78, 0.14 and 0.72, respectively. The proposed method incorporates the merits of fuzzy SVM and multi-pattern sample space learning, decomposing the MC detection problem into serial simple two-class classification. Experimental results from synthetic data and DDSM database demonstrate that our integrated classification framework reduces the false positive rate significantly while maintaining the true positive rate.

Macdonald polynomials from Sklyanin algebras: A conceptual basis for the p-adics-quantum group connection

International Nuclear Information System (INIS)

Freund, P.G.O.

1992-01-01

We establish a previously conjectured connection between p-adics and quantum groups. We find in Sklyanin's two parameter elliptic quantum algebra and its generalizations, the conceptual basis for the Macdonald polynomials, which 'interpolate' between the zonal spherical functions of related real and p-adic symmetric spaces. The elliptic quantum algebras underlie the Z n -Baxter models. We show that in the n→∞ limit, the Jost function for the scattering of first level excitations in the Z n -Baxter model coincides with the Harish-Chandra-like c-function constructed from the Macdonald polynomials associated to the root system A 1 . The partition function of the Z 2 -Baxter model itself is also expressed in terms of this Macdonald-Harish-Chandra c-function albeit in a less simple way. We relate the two parameters q and t of the Macdonald polynomials to the anisotropy and modular parameters of the Baxter model. In particular the p-acid 'regimes' in the Macdonald polynomials correspond to a discrete sequence of XXZ models. We also discuss the possibility of 'q-deforming' Euler products. (orig.)

Representation theory of 2-groups on finite dimensional 2-vector spaces

OpenAIRE

Elgueta, Josep

2004-01-01

In this paper, the 2-category $\\mathfrak{Rep}_{{\\bf 2Mat}_{\\mathbb{C}}}(\\mathbb{G})$ of (weak) representations of an arbitrary (weak) 2-group $\\mathbb{G}$ on (some version of) Kapranov and Voevodsky's 2-category of (complex) 2-vector spaces is studied. In particular, the set of equivalence classes of representations is computed in terms of the invariants $\\pi_0(\\mathbb{G})$, $\\pi_1(\\mathbb{G})$ and $[\\alpha]\\in H^3(\\pi_0(\\mathbb{G}),\\pi_1(\\mathbb{G}))$ classifying $\\mathbb{G}$. Also the categ...

International Space Station Earth Observations Working Group

Science.gov (United States)

Stefanov, William L.; Oikawa, Koki

2015-01-01

The multilateral Earth Observations Working Group (EOWG) was chartered in May 2012 in order to improve coordination and collaboration of Earth observing payloads, research, and applications on the International Space Station (ISS). The EOWG derives its authority from the ISS Program Science Forum, and a NASA representative serves as a permanent co-chair. A rotating co-chair position can be occupied by any of the international partners, following concurrence by the other partners; a JAXA representative is the current co-chair. Primary functions of the EOWG include, 1) the exchange of information on plans for payloads, from science and application objectives to instrument development, data collection, distribution and research; 2) recognition and facilitation of opportunities for international collaboration in order to optimize benefits from different instruments; and 3) provide a formal ISS Program interface for collection and application of remotely sensed data collected in response to natural disasters through the International Charter, Space and Major Disasters. Recent examples of EOWG activities include coordination of bilateral data sharing protocols between NASA and TsNIIMash for use of crew time and instruments in support of ATV5 reentry imaging activities; discussion of continued use and support of the Nightpod camera mount system by NASA and ESA; and review and revision of international partner contributions on Earth observations to the ISS Program Benefits to Humanity publication.

Biological effects of space flight on SP{sub 1} traits of fenugreek

Energy Technology Data Exchange (ETDEWEB)

Rong, Xu; Jing, Yu; Jiang, Xu; Feng, Zhou; Jun, Chen [The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Beijing Union Medical College, Beijing (China); Yougang, Liu [Tianjin Univ. of Traditional Chinese Medicine, Tianjin (China); Suqin, Sun [Department of Chemistry, Tsinghua Univ., Beijing (China)

2009-04-15

Fenugreek (Trigonella Foenum-graecum L.) seeds introduced from United Arab Emirates (UAE) were carried to the space by the recoverable satellite 'Shi Jian 8'. After space loading, the seeds were planted to be observed and investigated compared to the control group. The results showed that the germination rate declined after space loading compared to the control group. SP{sub 1} plants grew inhibited first, and then vigorously later at the seedling stage. The branch number, pods and plant weight of SP{sub 1} plants' increased. More important, single pod was changed to dual pod. At the same time, the Fourier transform infrared spectroscopy (FT-IR) was used to analyze and appraise the fenugreek SP{sub 1} seeds. The results indicated that the major components and the structures remained intact, in another word, space mutation had no obvious effect on the quality of SP{sub 1} seeds. Based on the results, some variations mutated by space flight could appear at the present generation. These variations were important to gain high yield. (authors)

Evaluation of the effects of subgingival injection of Simvastatin on space re-opening after orthodontic space closure in adults.

Science.gov (United States)

Jahanbin, Arezoo; Abtahi, Mostafa; Namdar, Parastoo; Heravi, Farzin; Sadeghi, Fatemeh; Arab, Hamidreza; Shafaee, Hooman

2016-01-01

Background. This clinical trial evaluated the effect of Simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (GI) and clinical attachment loss (CAL). Methods. 16 females, 25-40 years old, with spaces between anterior mandibular teeth due to chronic periodontitis were participated in this study. The patients were randomly divided into control and experimental groups. In the experimental group, 1.2% Simvastatin gel and in the control group, 0.9% sodium chloride as a placebo was injected into the pocket depth of the six anterior teeth. The amount of space reopening, GI and CAL were measured. Results. No serious complications were observed during interventions and follow-up periods. Space re-opening was significantly reduced in patients receiving Simvastatin (P space re-opening after orthodontic space closure in human anterior teeth.

Support Group for Parents Coping with Children with Type 1 Diabetes.

Science.gov (United States)

Pate, Tanja; Rutar, Miha; Battelino, Tadej; Drobnič Radobuljac, Maja; Bratina, Nataša

2015-06-01

Type 1 diabetes is one of the most common chronic diseases in childhood. Active parental involvement, parental support in the diabetes management and family functioning are associated with optimal diabetes management and glycemic control. The purpose of this study was to assess parental satisfaction with participation in the group and their perceptions of the impact of the intervention on living and coping with childrens T1D. A sample of 34 parents of children with T1D participated in this trend study. The participants' experience and satisfaction with support group was measured by a self- evaluation questionnaire, designed for the purpose of the present study. Quantitative data show that parents were overall satisfied with almost all measured items of the evaluation questionnaire (wellbeing in the group, feeling secure, experiencing new things, being able to talk and feeling being heard) during the 4-year period. However, parents from the second and third season, on average, found that the support group has better fulfilled their expectations than the parents from the first season (p = 0,010). The qualitative analysis of the participants' responses to the open-ended questions was underpinned by four themes: support when confronting the diagnosis, transformation of the family dynamics, me as a parent, exchange of experience and good practice and facing the world outside the family. The presented parent support group showed to be a promising supportive, therapeutic and psychoeducative space where parents could strengthen their role in the upbringing of their child with T1D.

Diff(S1)/SL(2,R) and Teichmueller space

International Nuclear Information System (INIS)

Nag, S.; Verjovsky, A.

1988-08-01

It is shown that the unique homogeneous Kaehler metric carried by M=Diff(S 1 )/SL(2,R) induces the Weil-Petersson metric on the Teichmueller space. This is via our identification of M as a holomorphic submanifold of universal Teichmueller space T(1). The identification was obtained simply by noting that every diffeomorphism of S 1 is a quasisymmetric homeomorphism. Our computations allow us also to prove that every T(G), G any infinite Fuchsian group, projects out of M transversely. This last assertion is related to the ''fractal'' nature of G-invariant quasicircles. (author). 12 refs

Kinematic algebras, groups for elementary particles, and the geometry of momentum space

International Nuclear Information System (INIS)

Izmest'ev, A.A.

1986-01-01

It is shown that to each n-dimensional (n≥2) homogeneous isotropic Riemannian momentum (coordinate) space there corresponds a definite kinematic local algebra of operators N/sub a/, M/sub a//sub b/, P/sub a//sub ,/ ω(a,b = 1,2,...,n). In the three-dimensional case this gives the possibility of classifying particles in accordance with the algebras of the types of momentum space. The approach developed also makes it possible to obtain generalized equations describing particles of the different types. The operators under consideration satisfy not only the relevant algebra but also relations independent of the algebra that coincide in form with the Maxwell equations

ESTIMA, Neutron Width Level Spacing, Neutron Strength Function of S- Wave, P-Wave Resonances

International Nuclear Information System (INIS)

Fort, E.

1982-01-01

1 - Description of problem or function: ESTIMA calculates level spacing and neutron strength function of a mixed sequence of s- and p-wave resonances given a set of neutron widths as input parameters. Three algorithms are used, two of which calculate s-wave average parameters and assume that the reduced widths obey a Porter-Thomas distribution truncated by a minimum detection threshold. The third performs a maximum likelihood fit to a truncated chi-squared distribution of any specified number of degrees of freedom, i.e. it can be used for calculating s-wave or p-wave average parameters. Resonances of undeclared angular orbital momentum are divided into groups of probable s-wave and probable p-wave by a simple application of Bayes' Theorem. 2 - Method of solution: Three algorithms are used: i) GAMN method, based on simple moments properties of a Porter-Thomas distribution. ii) Missing Level Estimator, a simplified version of the algorithm used by the program BAYESZ. iii) ESTIMA, a maximum likelihood fit. 3 - Restrictions on the complexity of the problem: A maximum of 400 resonances is allowed in the version available from NEADB, however this restriction can be relaxed by increasing array dimensions

On the Chabauty space of locally compact abelian groups

OpenAIRE

Cornulier, Yves

2010-01-01

This paper contains several results about the Chabauty space of a general locally compact abelian group. Notably, we determine its topological dimension, we characterize when it is totally disconnected or connected; we characterize isolated points.

Effect of bisphosphonates on NFATc1 and correlators p-NF-κB and p-c-Jun in osteoclast differentiation

Directory of Open Access Journals (Sweden)

Wei DONG

2015-11-01

Full Text Available Objective　To study the effect of alendronate (ALN on NFATc1 and correlated signaling factors p-NF-κB and p-c-Jun in osteoclast differentiation. Methods　Osteoclasts were inductively cultivated with mouse mononuclear macrophage RAW264.7, and they were divided into 2 groups: group A (control group and group B (ALN-treated group. The protein expressions of NFATc1, p-NF-κB and p-c-Jun were determined with Western blotting at the 2nd day of cultivation; the expression of NFATc1 was assessed by immunofluorescent assay on the 4th day; and the osteoclast formation was examined on the 7th day of cultivation. RAW264.7 cells were inoculated on abrasive dentine disk, and divided into 2 groups and treated as mentioned above. The resorption function of osteoclast was observed on the 9th day of inoculation. Results　TRAP positive multinuclear osteoclasts were observed, and resorption lacunaes formed in the abrasive dentine disks of the 2 groups. More TRAP positive multinuclear cells and resorption lacunaes in large size were found in group A than those in group B. Immunofluorescence assay showed the expression of NFATc1 was higher in group A than in group B. The gene expressions of NFATc1, p-NF-κB and p-c-Jun were lower in group B than in group A(P<0.01 as determined with Western blotting. Conclusion　By down-regulating the expressions of p-NF-κB and p-c-Jun, ALN may strongly inhibit the osteoclast formation and its resorption function, thus inhibiting NFATc1 expression. DOI: 10.11855/j.issn.0577-7402.2015.10.02

Toward a standardized structural-functional group connectome in MNI space.

Science.gov (United States)

Horn, Andreas; Blankenburg, Felix

2016-01-01

The analysis of the structural architecture of the human brain in terms of connectivity between its subregions has provided profound insights into its underlying functional organization and has coined the concept of the "connectome", a structural description of the elements forming the human brain and the connections among them. Here, as a proof of concept, we introduce a novel group connectome in standard space based on a large sample of 169 subjects from the Enhanced Nathan Kline Institute-Rockland Sample (eNKI-RS). Whole brain structural connectomes of each subject were estimated with a global tracking approach, and the resulting fiber tracts were warped into standard stereotactic (MNI) space using DARTEL. Employing this group connectome, the results of published tracking studies (i.e., the JHU white matter and Oxford thalamic connectivity atlas) could be largely reproduced directly within MNI space. In a second analysis, a study that examined structural connectivity between regions of a functional network, namely the default mode network, was reproduced. Voxel-wise structural centrality was then calculated and compared to others' findings. Furthermore, including additional resting-state fMRI data from the same subjects, structural and functional connectivity matrices between approximately forty thousand nodes of the brain were calculated. This was done to estimate structure-function agreement indices of voxel-wise whole brain connectivity. Taken together, the combination of a novel whole brain fiber tracking approach and an advanced normalization method led to a group connectome that allowed (at least heuristically) performing fiber tracking directly within MNI space. Such an approach may be used for various purposes like the analysis of structural connectivity and modeling experiments that aim at studying the structure-function relationship of the human connectome. Moreover, it may even represent a first step toward a standard DTI template of the human brain

Knot wormholes and the dimensional invariant of exceptional Lie groups and Stein space hierarchies

International Nuclear Information System (INIS)

Elokaby, Ayman

2009-01-01

The present short note points out a most interesting and quite unexpected connection between the number of distinct knot as a function of their crossing number and exceptional Lie groups and Stein space hierarchies. It is found that the crossing number 7 plays the role of threshold similar to 4 and 5 in E-infinity theory and for the 11 crossing the number of distinct knots is very close to 4α-bar 0 +1=548+1=549, where α-bar 0 =137 is the inverse integer electromagnetic fine structure constant. This is particularly intriguing in view of a similar relation pertinent to the 17 two and three Stein spaces where the total dimension is Σ 1 17 Stein=5α-bar 0 +1=685+1=686, as well as the sum of the eight exceptional Lie symmetry groups Σ i=1 8 |E i |=4α-bar 0 =548. The slight discrepancy of one is explained in both cases by the inclusion of El Naschie's transfinite corrections leading to Σ i=1 8 |E i |=(4)(137+k 0 )=548.328157 and Σ i=1 17 Stein=(5)(137+k 0 )=685.41097, where k o = φ 5 (1 - φ 5 ) and φ=(√(5)-1)/2.

MOLECULAR OXYGEN IN OORT CLOUD COMET 1P/HALLEY

Energy Technology Data Exchange (ETDEWEB)

Rubin, M.; Altwegg, K. [Physikalisches Institut, University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Dishoeck, E. F. van [Leiden Observatory, Leiden University, P.O. Box 9513, 2300 RA Leiden (Netherlands); Schwehm, G. [ESA (retired) Science Operations Department, ESTEC, Keplerlaan 1, 2201 AZ Noordwijk (Netherlands)

2015-12-10

Recently, the ROSINA mass spectrometer suite on board the European Space Agency's Rosetta spacecraft discovered an abundant amount of molecular oxygen, O{sub 2}, in the coma of Jupiter family comet 67P/Churyumov–Gerasimenko of O{sub 2}/H{sub 2}O = 3.80 ± 0.85%. It could be shown that O{sub 2} is indeed a parent species and that the derived abundances point to a primordial origin. Crucial questions are whether the O{sub 2} abundance is peculiar to comet 67P/Churyumov–Gerasimenko or Jupiter family comets in general, and also whether Oort cloud comets such as comet 1P/Halley contain similar amounts of molecular oxygen. We investigated mass spectra obtained by the Neutral Mass Spectrometer instrument during the flyby by the European Space Agency's Giotto probe of comet 1P/Halley. Our investigation indicates that a production rate of O{sub 2} of 3.7 ± 1.7% with respect to water is indeed compatible with the obtained Halley data and therefore that O{sub 2} might be a rather common and abundant parent species.

P-Adic analysis and the transfinite E8 exceptional Lie symmetry group unification

Energy Technology Data Exchange (ETDEWEB)

El Naschie, M.S. [King Abdullah Institute for Nano and Advanced Technology, KSU, Riyadh (Saudi Arabia)], E-mail: Chaossf@aol.com

2008-11-15

In P-Adic analysis like in a fractal Cantorian space there is no absolute scale. P-Adic analysis with its prime numbers base is the mathematical quarks of the exceptional E8 and E-infinity. The P-Adic space permits the use of Weyl original spacetime gauge theory which is the rationale behind E-infinity.

P-Adic analysis and the transfinite E8 exceptional Lie symmetry group unification

International Nuclear Information System (INIS)

El Naschie, M.S.

2008-01-01

In P-Adic analysis like in a fractal Cantorian space there is no absolute scale. P-Adic analysis with its prime numbers base is the mathematical quarks of the exceptional E8 and E-infinity. The P-Adic space permits the use of Weyl original spacetime gauge theory which is the rationale behind E-infinity

Pancreas of C57 black mice after long-term space flight (Bion-M1 Space Mission)

Science.gov (United States)

Proshchina, A. E.; Krivova, Y. S.; Saveliev, S. C.

2015-11-01

In this study, we analysed the pancreases of C57BL/6N mice in order to estimate the effects of long-term space flights. Mice were flown aboard the Bion-M1 biosatellite, or remained on ground in the control experiment that replicated environmental and housing conditions in the spacecraft. Vivarium control group was used to account for housing effects. Each of the groups included mice designated for recovery studies. Mice pancreases were dissected for histological and immunohistochemical examinations. Using a morphometry and statistical analysis, a strong correlation between the mean islet size and the mean body weight was revealed in all groups. Therefore, we propose that hypokinesia and an increase in nutrition play an important role in alterations of the endocrine pancreas, both in space flight and terrestrial conditions.

IN VITRO STUDIES ON HEME OXYGENASE-1 AND P24 ANTIGEN HIV-1 LEVEL AFTERHYPERBARIC OXYGEN TREATMENTOFHIV-1 INFECTED ON PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS).

Science.gov (United States)

Budiarti, Retno; Kuntaman; Nasronudin; Suryokusumo; Khairunisa, Siti Qamariyah

2018-01-01

Heme oxygenase-1 (HO-1) is a protein secreted by immune cells as a part of immune response mechanism.HO-1 can be induced by variety agents that causingoxidative stress, such as exposure to 100% oxygenat2,4 ATA pressure.It plays a vital role in maintaining cellular homeostasis.This study was conducted to identify the effect of hyperbaric oxygen exposure in cultured ofPBMCthat infected by HIV-1. Primary culture of PBMCs were isolated from 16 healthy volunteers and HIV-1 infected MT4 cell line by co-culture. The PBMCs were aliquoted into two wells as control group and treatment group. The 16 samples of HIV-1 infected PBMCwere exposed to oxygen at 2,4 ATA in animal hyperbaric chamber forthree times in 30 minutes periods with 5 minutes spacing period, that called 1 session.The Treatment done on 5 sessions within 5 days. 16 samples of HIV-1 infected PMBCs that have no hyperbaric treatment became control group.The supernatant were measured the HO-1 production by ELISA andmRNA expression of HO-1 by real time PCR and the number ofantigen p24 HIV-1by ELISA. The result showed that there was no increasing of HO-1 at both mRNA level and protein level, there was a decreasing number of antigen p24 HIV-1 at the treatment group. In addition, hyperbaric exposure could not increase the expression of HO-1, more over the viral replication might be reduced by other mechanism. Hyperbaric oxygen could increases cellular adaptive response of PBMCs infected HIV-1 through increased expression of proteins that can inhibit HIV viralreplication.

Comparative analysis between P1 and B1 equations for neutron moderation

International Nuclear Information System (INIS)

Martinez, Aquilino Senra; Silva, Fernando Carvalho da; Cardoso, Carlos Eduardo Santos

2000-01-01

In order to calculate the neutron flux in nuclear reactors, B1 or P1 equations are solved by numerical methods for several groups of energy. The neutron fluxes obtained from the solutions of the B1 and P1 equations are similar when they are applied to large nuclear power reactors. However, an important difference between the two fluxes is that the system of P1 equations uses one more approximation than the B1 system and then, its flux is less precise. The present work shows the relations between both equations and analyzes for what conditions the two equations systems are equivalent. Furthermore, this equations are numerically solved in 54 groups of energy for a quadrangular arrange. (author)

N-1: Safeguards Science and Technology Group, Tour Areas

International Nuclear Information System (INIS)

Geist, William H.

2012-01-01

Group N-1 develops and provides training on nondestructive assay (NDA) technologies intended for nuclear material accounting and control to fulfill both international and domestic obligations. The N-1 group is located at Technical Area (TA)-35 in Buildings 2 and 27. Visitors to the area can observe developed and fielded NDA technologies, as well as the latest research efforts to develop the next generation of NDA technologies. Several areas are used for NDA training. The N-1 School House area typically is used for basic training on neutron- and gamma-ray-based NDA techniques. This area contains an assortment of gamma-ray detector systems, including sodium iodide and high-purity germanium and the associated measurement components. Many types of neutron assay systems are located here, including both standard coincidence and multiplicity counters. The N-1 School House area is also used for holdup training; located here are the mock holdup assemblies and associated holdup measurement tools. Other laboratory areas in the N-1 space are used for specialized training, such as waste NDA, calorimetry, and advanced gamma-ray NDA. Also, many research laboratories in the N-1 space are used to develop new NDA technologies. The calorimetry laboratory is used to develop and evaluate new technologies and techniques that measure the heat signature from nuclear material to determine mass. The micro calorimetry laboratory is being used to develop advanced technologies that can measure gamma rays with extremely high resolution. This technique has been proven in the laboratory setting, and the team is now working to cultivate a field-capable system. The N-1 group also develops remote and unattended systems for the tracking and control of nuclear material. A demonstration of this technology is located within one of the laboratory spaces. The source tracker software was developed by N-1 to monitor the locations and quantities of nuclear materials. This software is currently used to track

The deep space 1 extended mission

Science.gov (United States)

Rayman, Marc D.; Varghese, Philip

2001-03-01

The primary mission of Deep Space 1 (DS1), the first flight of the New Millennium program, completed successfully in September 1999, having exceeded its objectives of testing new, high-risk technologies important for future space and Earth science missions. DS1 is now in its extended mission, with plans to take advantage of the advanced technologies, including solar electric propulsion, to conduct an encounter with comet 19P/Borrelly in September 2001. During the extended mission, the spacecraft's commercial star tracker failed; this critical loss prevented the spacecraft from achieving three-axis attitude control or knowledge. A two-phase approach to recovering the mission was undertaken. The first involved devising a new method of pointing the high-gain antenna to Earth using the radio signal received at the Deep Space Network as an indicator of spacecraft attitude. The second was the development of new flight software that allowed the spacecraft to return to three-axis operation without substantial ground assistance. The principal new feature of this software is the use of the science camera as an attitude sensor. The differences between the science camera and the star tracker have important implications not only for the design of the new software but also for the methods of operating the spacecraft and conducting the mission. The ambitious rescue was fully successful, and the extended mission is back on track.

Extended system of space-time coordinates and generalized translation group of transformations

International Nuclear Information System (INIS)

Yamaleev, R.M.

1980-01-01

A method of extending space-time is considered. In the nonrelativistic case extending goes by joining a scalar to the 3-dimensional radius-vector, completing this to a quaternion. The interpretation of scalar obtained as a parameter of scale transfornation of the generalized translation of group of transformations is given. Some basic expressions of nonrelativistic classical mechanics in the quaternion representation are given. In the relativistic case space-time is constructed from two quaternions: the first one consists of a pair scalar-3-dimensional radius-vector; the second one, of a pair-time-scalar-3-dimensional time-vector. Time and space coordinates, enter into the expression with the opposite signature. The introduction of a time-vector as well as of a new scalar is stipulated by the requirement of the principle of conforming quantum mechanics of the 1/2 spin to classical mechanics [ru

Using the 5 P Relay in Task Groups

Science.gov (United States)

Stanley, Paula Helen

2006-01-01

This article describes the 5 P Relay, a group exercise that can increase the effectiveness of task groups. The 5 P Relay is based on the principles and concepts of the Invitational Model, which emphasizes the importance of assessing the effectiveness or health of five aspects of an organization's environment: people, places, programs, processes,…

Identification of a High-Risk Group Among Patients With Oral Cavity Squamous Cell Carcinoma and pT1-2N0 Disease

Energy Technology Data Exchange (ETDEWEB)

Liao, Chun-Ta [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Lin, Chien-Yu [Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Radiation Oncology, Chang Gung Memorial Hospital and Graduate Institute of Clinical Medical Sciences of Chang Gung University, Taoyuan, Taiwan (China); Fan, Kang-Hsing [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Radiation Oncology, Chang Gung Memorial Hospital and Graduate Institute of Clinical Medical Sciences of Chang Gung University, Taoyuan, Taiwan (China); Wang, Hung-Ming [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Hema-Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Ng, Shu-Hang [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Diagnostic Radiology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Lee, Li-Yu; Hsueh, Chuen [Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Chen, I-How; Huang, Shiang-Fu; Kang, Chung-Jan [Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); Department of Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan (China); and others

2012-01-01

Purpose: In the American Joint Committee on Cancer 2010 classification system, pT1-2N0 oral cavity squamous cell carcinoma (OSCC) is considered an early-stage cancer treatable with surgery alone (National Comprehensive Cancer Network 2010 guidelines). Our aim was to evaluate the feasibility of surgery alone for pT1-2N0 OSCC patients. Methods and Materials: Among 1279 previously untreated OSCC patients referred to our hospital between January 1996 and May 2008, we identified 457 consecutive patients with pT1-2N0 disease. All had radical tumor excision with neck dissection. A total of 387 patients showing pathologic margins greater than 4 mm and treated by surgery alone were included in the final analysis. All were followed up for at least 24 months after surgery or until death. The 5-year rates of control, distant metastasis, and survival were the main outcome measures. Results: The 5-year rates in the entire group of pT1-2N0 patients were as follows: local control, 91%; neck control, 92%; distant metastases, 1%; disease-free survival, 85%; disease-specific survival, 93%; and overall survival, 84%. Multivariate analysis identified poor differentiation and pathologic tumor depth of 4 mm or greater as independent risk factors for neck control, disease-free survival, and disease-specific survival. A scoring system using poor differentiation and tumor depth was formulated to define distinct prognostic groups. The presence of both poorly differentiated tumors and a tumor depth of 4 mm or greater resulted in significantly poorer 5-year neck control (p < 0.0001), disease-free (p < 0.0001), disease-specific (p < 0.0001), and overall survival (p = 0.0046) rates. Conclusion: The combination of poor differentiation and pathologic tumor depth of 4 mm or greater identified a subset of pT1-2N0 OSCC patients with poor outcome, who may have clinical benefit from postoperative adjuvant radiotherapy.

[An updated review of 1p36 deletion (monosomy) syndrome].

Science.gov (United States)

Bello, Sabina; Rodríguez-Moreno, Antonio

The Monosomy 1p36 deletion syndrome is part of the group of diseases known as Rare Diseases. The objective of the present work is to review the characteristics of Monosomy 1p36 deletion syndrome. The monosomy 1p36 deletion syndrome phenotype includes: dysmorphic craniofacial features; large anterior fontanelle, unibrow, deep-set eyes, epicanthus, wide nasal root/bridge, mandible hypoplasia, abnormal location of the pinna, philtrum and pointed chin; neurological alterations: seizures and hydrocephalus (in some cases). Cerebral malformations: ventricular hypertrophy, increased subarachnoid space, morphological alterations of corpus callosum, cortical atrophy, delays in myelinisation, periventricular leukomalacia and periventricular heterotopia. These alterations produce intellectual disability and delays in motor growth, communication skills, language, social and adaptive behaviour. It is Hearing and vision impairments are also observed in subjects with this syndrome, as well as alterations of cardiac, endocrine and urinary systems and alterations at skin and skeletal level. Approximately 100 cases have been documented since 1981. This rare disease is the most common subtelomeric-micro-deletion syndrome. In situ hybridization with fluorescence (FISH) and array-comparative genomic hybridization (CGH-array) are at present the two best diagnostic techniques. There is currently no effective medical treatment for this disease. Copyright © 2016 Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

An introduction to Lie groups and the geometry of homogeneous spaces

CERN Document Server

Arvanitoyeorgos, Andreas

2003-01-01

It is remarkable that so much about Lie groups could be packed into this small book. But after reading it, students will be well-prepared to continue with more advanced, graduate-level topics in differential geometry or the theory of Lie groups. The theory of Lie groups involves many areas of mathematics. In this book, Arvanitoyeorgos outlines enough of the prerequisites to get the reader started. He then chooses a path through this rich and diverse theory that aims for an understanding of the geometry of Lie groups and homogeneous spaces. In this way, he avoids the extra detail needed for a thorough discussion of other topics. Lie groups and homogeneous spaces are especially useful to study in geometry, as they provide excellent examples where quantities (such as curvature) are easier to compute. A good understanding of them provides lasting intuition, especially in differential geometry. The book is suitable for advanced undergraduates, graduate students, and research mathematicians interested in differenti...

Determining sociability, social space, and social presence in (a)synchronous collaborative groups.

Science.gov (United States)

Kreijns, Karel; Kirschner, Paul A; Jochems, Wim; Van Buuren, Hans

2004-04-01

The effectiveness of group learning in asynchronous distributed learning groups depends on the social interaction that takes place. This social interaction affects both cognitive and socioemotional processes that take place during learning, group forming, establishment of group structures, and group dynamics. Though now known to be important, this aspect is often ignored, denied or forgotten by educators and researchers who tend to concentrate on cognitive processes and on-task contexts. This "one-sided" educational focus largely determines the set of requirements in the design of computer-supported collaborative learning (CSCL) environments resulting in functional CSCL environments. In contrast, our research is aimed at the design and implementation of sociable CSCL environments which may increase the likelihood that a sound social space will emerge. We use a theoretical framework that is based upon an ecological approach to social interaction, centering on the concept of social affordances, the concept of the sociability of CSCL environments, and social presence theory. The hypothesis is that the higher the sociability, the more likely that social interaction will take place or will increase, and the more likely that this will result in an emerging sound social space. In the present research, the variables of interest are sociability, social space, and social presence. This study deals with the construction and validation of three instruments to determine sociability, social space, and social presence in (a)synchronous collaborating groups. The findings suggest that the instruments have potential to be useful as measures for the respective variables. However, it must be realized that these measures are "first steps."

Analysis of Adult Female Mouse (Mus musculus) Group Behavior on the International Space Station (ISS)

Science.gov (United States)

Solomides, P.; Moyer, E. L.; Talyansky, Y.; Choi, S.; Gong, C.; Globus, R. K.; Ronca, A. E.

2016-01-01

As interest in long duration effects of space habitation increases, understanding the behavior of model organisms living within the habitats engineered to fly them is vital for designing, validating, and interpreting future spaceflight studies. A handful of papers have previously reported behavior of mice and rats in the weightless environment of space. The Rodent Research Hardware and Operations Validation (Rodent Research-1; RR1) utilized the Rodent Habitat (RH) developed at NASA Ames Research Center to fly mice on the ISS (International Space Station). Ten adult (16-week-old) female C57BL/6 mice were launched on September 21st, 2014 in an unmanned Dragon Capsule, and spent 37 days in microgravity. Here we report group behavioral phenotypes of the RR1 Flight (FLT) and environment-matched Ground Control (GC) mice in the Rodent Habitat (RH) during this long-duration flight. Video was recorded for 33 days on the ISS, permitting daily assessments of overall health and well-being of the mice, and providing a valuable repository for detailed behavioral analysis. We previously reported that, as compared to GC mice, RR1 FLT mice exhibited the same range of behaviors, including eating, drinking, exploration, self- and allo-grooming, and social interactions at similar or greater levels of occurrence. Overall activity was greater in FLT as compared to GC mice, with spontaneous ambulatory behavior, including organized 'circling' or 'race-tracking' behavior that emerged within the first few days of flight following a common developmental sequence, and comprised the primary dark cycle activity persisting throughout the remainder of the experiment. Participation by individual mice increased dramatically over the course of the flight. Here we present a detailed analysis of 'race-tracking' behavior in which we quantified: (1) Complete lap rotations by individual mice; (2) Numbers of collisions between circling mice; (3) Lap directionality; and (4) Recruitment of mice into a group

Holomorphic representation of constant mean curvature surfaces in Minkowski space: Consequences of non-compactness in loop group methods

DEFF Research Database (Denmark)

Brander, David; Rossman, Wayne; Schmitt, Nicholas

2010-01-01

We give an infinite dimensional generalized Weierstrass representation for spacelike constant mean curvature (CMC) surfaces in Minkowski 3-space $\\R^{2,1}$. The formulation is analogous to that given by Dorfmeister, Pedit and Wu for CMC surfaces in Euclidean space, replacing the group $SU_2$ with...

Closed 1-forms in topology and geometric group theory

Energy Technology Data Exchange (ETDEWEB)

Farber, Michael; Schuetz, Dirk [University of Durham, Durham (United Kingdom); Geoghegan, Ross [State University of New York, New York (United States)

2010-01-01

In this article we describe relations of the topology of closed 1-forms to the group-theoretic invariants of Bieri-Neumann-Strebel-Renz. Starting with a survey, we extend these Sigma invariants to finite CW-complexes and show that many properties of the group-theoretic version have analogous statements. In particular, we show the relation between Sigma invariants and finiteness properties of certain infinite covering spaces. We also discuss applications of these invariants to the Lusternik-Schnirelmann category of a closed 1-form and to the existence of a non-singular closed 1-form in a given cohomology class on a high-dimensional closed manifold. Bibliography: 32 titles.

Structure of some relative relation modules of finite p-groups

International Nuclear Information System (INIS)

Yamin, M.

1990-06-01

Let G be a finite p-group generated by (g i , 1 ≤ i ≤ d), G i the cyclic subgroup generated by g i , E the free product of the G i , 1 ≤ i ≤ d, and S the kernel of the natural epimorphism of E onto G. The largest elementary abelian p-quotient S-circumflex = S/S'S p , regarded as an IF p G-module via conjugation in E, is called a relative relation module of G. If d is the minimum number of generaters for G, the author has proved that S-circumflex is nonprojective and indecomposable. The aim of this paper is to give an alternative proof for the indecomposability of S-circumflex; the proof here is more informative as it deals with Loewy structure and generating sets of S-circumflex and other associated modules. (author). 9 refs

A de-novo interstitial microduplication involving 2p16.1-p15 and mirroring 2p16.1-p15 microdeletion syndrome: Clinical and molecular analysis.

Science.gov (United States)

Mimouni-Bloch, Aviva; Yeshaya, Josepha; Kahana, Sarit; Maya, Idit; Basel-Vanagaite, Lina

2015-11-01

Microdeletions of various sizes in the 2p16.1-p15 chromosomal region have been grouped together under the 2p16.1-p15 microdeletion syndrome. Children with this syndrome generally share certain features including microcephaly, developmental delay, facial dysmorphism, urogenital and skeletal abnormalities. We present a child with a de-novo interstitial 1665 kb duplication of 2p16.1-p15. Clinical features of this child are distinct from those of children with the 2p16.1-p15 microdeletion syndrome, specifically the head circumference which is within the normal range and mild intellectual disability with absence of autistic behaviors. Microduplications many times bear milder clinical phenotypes in comparison with corresponding microdeletion syndromes. Indeed, as compared to the microdeletion syndrome patients, the 2p16.1-p15 microduplication seems to have a milder cognitive effect and no effect on other body systems. Limited information available in genetic databases about cases with overlapping duplications indicates that they all have abnormal developmental phenotypes. The involvement of genes in this location including BCL11A, USP34 and PEX13, affecting fundamental developmental processes both within and outside the nervous system may explain the clinical features of the individual described in this report. Copyright © 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

The complex structures on the coadjoint orbit spaces of Diff(S1) and on Bers' universal Teichmueller space are compatible

International Nuclear Information System (INIS)

Nag, S.; Verjovsky, A.

1988-08-01

Precisely two coadjoint orbit spaces of the group of string reparametrizations carry in a natural way the structure of infinite dimensional, holomorphically homogeneous complex manifolds. These are M 1 =Diff(S 1 )/Rot(S 1 ) and M 2 =Diff(S 1 )/Mo-barb(S 1 ). M 2 can be naturally considered as (embedded in) the classical univeral Teichmueller space T(Δ), simply by noting that a diffeomorphism of S 1 is a quasi-symmetric homeomorphism. T(Δ) is itself a homomorphically homogeneous complex Banach manifold. We prove that the inclusion of M 2 in T(Δ) is complex analytic. Every Teichmueller space of finite or infinite dimension is contained canonically and holomorphically in T(Δ). Our result thus appears to connect the loop space approach to bosonic string theory with the sum-over moduli (Polyakov path integral) approach. (author). 12 refs

SUSY search using trilepton events from p bar p collisions at √s = 1.8 TeV

International Nuclear Information System (INIS)

1993-08-01

In a preliminary analysis, we have looked for evidence of the production and decay of SUSY chargino-neutralino (often referred to as Wino-Zino) pairs into the trilepton events using 11.1 pb -1 of p bar p collision data at √s = 1.8 TeV collected in 1992--1993 by CDF. Using all possible electron and muon decay channels, we observe two events which pass our trilepton criteria. Assuming, for the purposes of a conservative limit, that these events are all signal events, we exclude a point in the parameter space of the Minimal Supersymmetric Standard Model (MSSM) which corresponds to the limit of sensitivity of LEP measurements. Systematic errors have not been included in the result. Larger data samples and a more careful treatment should allow a large region of MSSM parameter space to be explored using the trilepton channel

X-ray Molecular Structure of ({[(1E)-3-(1H-Imidazol-1-yl)-1 ...

African Journals Online (AJOL)

1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud ... Results: The titled compound crystallized in the triclinic space group P-1 with a = 11.0719 (7) Е, b = ..... Jeng MR, Feusner J. Itraconazole-enhanced vincristine.

The reaction of TcCl3(Me2PhP)3 with dithio ligands. Synthesis, characterization and X-ray crystal structures of [TcCl2(Me2PhP)2(Me2dtp)]and [Tc(Me2PhP)(Etxan)3](Me2PhP=dimethylphenylphosphine, Me2dtp-=O,O'-dimethyldithiophosphate, Etxan-=ethylxanthate)

International Nuclear Information System (INIS)

Lorenz, B.; Schmidt, K.; Hiller, W.; Abram, U.; Huebener, R.

1993-01-01

Trichlorotris (dimethylphenylphosphine)technetium(III); [TcCl 3 (Me 2 PhP) 3 ], reacts with dithio ligands to form chelate complexes of different compositions and coordinations geometries. The reaction with ethylxanthate (Etxan - ) yields the diamagnetic seven-coordinate [Tc(Me 2 PhP)(Etxan) 3 ], which crystallizes monoclinic in the space group P2 2 /c with Z = 4 (a = 18.44(5), b = 9.2(1), c = 15.36(6) A, β = 104.3(2) ). The final R value is 0.029. The metal has a pentagonal-bipyramidal environment. With ammonium dimethyldithiophosphate, (NH 4 )Me 2 dtp, [TcCl 3 (Me 2 PhP) 3 ] forms the paramagnetic [TcCl 2 (Me 2 PhP) 2 (Me 2 dtp) in which the technetium atom has a distorted octahedral coordination sphere. The compound crystallizes orthorhombic, space group Pbcn, with Z = 4 (a = 16.20(1), b = 10.445(1), c 14.878(1)). The final R value is 0.031. The chloro ligands are in trans arrangement. (orig.)

Independence of automorphism group, center, and state space of quantum logics

International Nuclear Information System (INIS)

Navara, M.

1992-01-01

We prove that quantum logics (-orthomodular posets) admit full independence of the attributes important within the foundations of quantum mechanics. Namely, we present the construction of quantum logics with given sublogics (=physical subsystems), automorphism groups, centers (=open-quotes classical partsclose quotes of the systems), and state spaces. Thus, all these open-quotes parametersclose quotes are independent. Our result is rooted in the line of investigation carried out by Greechie; Kallus and Trnkova; Kalmbach; and Navara and Ptak; and considerably enriches the known algebraic methods in orthomodular posets. 19 refs., 1 fig

Identification of a High-Risk Group Among Patients With Oral Cavity Squamous Cell Carcinoma and pT1–2N0 Disease

International Nuclear Information System (INIS)

Liao, Chun-Ta; Lin, Chien-Yu; Fan, Kang-Hsing; Wang, Hung-Ming; Ng, Shu-Hang; Lee, Li-Yu; Hsueh, Chuen; Chen, I-How; Huang, Shiang-Fu; Kang, Chung-Jan

2012-01-01

Purpose: In the American Joint Committee on Cancer 2010 classification system, pT1–2N0 oral cavity squamous cell carcinoma (OSCC) is considered an early-stage cancer treatable with surgery alone (National Comprehensive Cancer Network 2010 guidelines). Our aim was to evaluate the feasibility of surgery alone for pT1–2N0 OSCC patients. Methods and Materials: Among 1279 previously untreated OSCC patients referred to our hospital between January 1996 and May 2008, we identified 457 consecutive patients with pT1–2N0 disease. All had radical tumor excision with neck dissection. A total of 387 patients showing pathologic margins greater than 4 mm and treated by surgery alone were included in the final analysis. All were followed up for at least 24 months after surgery or until death. The 5-year rates of control, distant metastasis, and survival were the main outcome measures. Results: The 5-year rates in the entire group of pT1–2N0 patients were as follows: local control, 91%; neck control, 92%; distant metastases, 1%; disease-free survival, 85%; disease-specific survival, 93%; and overall survival, 84%. Multivariate analysis identified poor differentiation and pathologic tumor depth of 4 mm or greater as independent risk factors for neck control, disease-free survival, and disease-specific survival. A scoring system using poor differentiation and tumor depth was formulated to define distinct prognostic groups. The presence of both poorly differentiated tumors and a tumor depth of 4 mm or greater resulted in significantly poorer 5-year neck control (p < 0.0001), disease-free (p < 0.0001), disease-specific (p < 0.0001), and overall survival (p = 0.0046) rates. Conclusion: The combination of poor differentiation and pathologic tumor depth of 4 mm or greater identified a subset of pT1–2N0 OSCC patients with poor outcome, who may have clinical benefit from postoperative adjuvant radiotherapy.

Crystallization and preliminary X-ray diffraction studies of polyketide synthase-1 (PKS-1) from Cannabis sativa

International Nuclear Information System (INIS)

Taguchi, Chiho; Taura, Futoshi; Tamada, Taro; Shoyama, Yoshinari; Shoyama, Yukihiro; Tanaka, Hiroyuki; Kuroki, Ryota; Morimoto, Satoshi

2008-01-01

Polyketide synthase-1 from C. sativa has been crystallized. The crystal diffracted to 1.55 Å resolution with sufficient quality for further structure determination. Polyketide synthase-1 (PKS-1) is a novel type III polyketide synthase that catalyzes the biosynthesis of hexanoyl triacetic acid lactone in Cannabis sativa (Mexican strain). PKS-1 was overproduced in Escherichia coli, purified and finally crystallized in two different space groups. The crystal obtained in 0.1 M HEPES buffer pH 7.5 containing 0.2 M calcium acetate and 20%(w/v) polyethylene glycol 3350 diffracted to 1.65 Å resolution and belonged to space group P1, with unit-cell parameters a = 54.3, b = 59.3, c = 62.6 Å, α = 69, β = 81, γ = 80°. Another crystal obtained in 0.1 M HEPES buffer pH 7.5 containing 0.2 M sodium chloride and 20%(w/v) polyethylene glycol 3350 diffracted to 1.55 Å resolution and belonged to space group P2 1 2 1 2 1 , with unit-cell parameters a = 54.3, b = 110, c = 130 Å. These data will enable us to determine the crystal structure of PKS-1

Crystallization and preliminary X-ray diffraction studies of polyketide synthase-1 (PKS-1) from Cannabis sativa

Energy Technology Data Exchange (ETDEWEB)

Taguchi, Chiho [Faculty of Pharmaceutical Sciences, Kyushu University (Japan); Quantum Beam Science Directorate, Japan Atomic Energy Agency (Japan); Taura, Futoshi [Faculty of Pharmaceutical Sciences, Kyushu University (Japan); Tamada, Taro; Shoyama, Yoshinari [Quantum Beam Science Directorate, Japan Atomic Energy Agency (Japan); Shoyama, Yukihiro; Tanaka, Hiroyuki [Faculty of Pharmaceutical Sciences, Kyushu University (Japan); Kuroki, Ryota [Quantum Beam Science Directorate, Japan Atomic Energy Agency (Japan); Morimoto, Satoshi [Faculty of Pharmaceutical Sciences, Kyushu University (Japan)

2008-03-01

Polyketide synthase-1 from C. sativa has been crystallized. The crystal diffracted to 1.55 Å resolution with sufficient quality for further structure determination. Polyketide synthase-1 (PKS-1) is a novel type III polyketide synthase that catalyzes the biosynthesis of hexanoyl triacetic acid lactone in Cannabis sativa (Mexican strain). PKS-1 was overproduced in Escherichia coli, purified and finally crystallized in two different space groups. The crystal obtained in 0.1 M HEPES buffer pH 7.5 containing 0.2 M calcium acetate and 20%(w/v) polyethylene glycol 3350 diffracted to 1.65 Å resolution and belonged to space group P1, with unit-cell parameters a = 54.3, b = 59.3, c = 62.6 Å, α = 69, β = 81, γ = 80°. Another crystal obtained in 0.1 M HEPES buffer pH 7.5 containing 0.2 M sodium chloride and 20%(w/v) polyethylene glycol 3350 diffracted to 1.55 Å resolution and belonged to space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 54.3, b = 110, c = 130 Å. These data will enable us to determine the crystal structure of PKS-1.

Measurement of the production cross section ratio $\\sigma(\\chi_{b2}(1\\mathrm{P}))/ \\sigma(\\chi_{b1}(1\\mathrm{P}))$ in pp collisions at $\\sqrt{s}$ = 8 TeV

CERN Document Server

Khachatryan, Vardan; Tumasyan, Armen; Adam, Wolfgang; Bergauer, Thomas; Dragicevic, Marko; Erö, Janos; Fabjan, Christian; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; Kiesenhofer, Wolfgang; Knünz, Valentin; Krammer, Manfred; Krätschmer, Ilse; Liko, Dietrich; Mikulec, Ivan; Rabady, Dinyar; Rahbaran, Babak; Rohringer, Herbert; Schöfbeck, Robert; Strauss, Josef; Taurok, Anton; Treberer-Treberspurg, Wolfgang; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Alderweireldt, Sara; Bansal, Monika; Bansal, Sunil; Cornelis, Tom; De Wolf, Eddi A; Janssen, Xavier; Knutsson, Albert; Luyckx, Sten; Ochesanu, Silvia; Roland, Benoit; Rougny, Romain; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Blekman, Freya; Blyweert, Stijn; D'Hondt, Jorgen; Daci, Nadir; Heracleous, Natalie; Keaveney, James; Lowette, Steven; 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Razis, Panos A; Bodlak, Martin; Finger, Miroslav; Finger Jr, Michael; Assran, Yasser; Ellithi Kamel, Ali; Mahmoud, Mohammed; Radi, Amr; Kadastik, Mario; Murumaa, Marion; Raidal, Martti; Tiko, Andres; Eerola, Paula; Fedi, Giacomo; Voutilainen, Mikko; Härkönen, Jaakko; Karimäki, Veikko; Kinnunen, Ritva; Kortelainen, Matti J; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Mäenpää, Teppo; Peltola, Timo; Tuominen, Eija; Tuominiemi, Jorma; Tuovinen, Esa; Wendland, Lauri; Tuuva, Tuure; Besancon, Marc; Couderc, Fabrice; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis; Favaro, Carlotta; Ferri, Federico; Ganjour, Serguei; Givernaud, Alain; Gras, Philippe; Hamel de Monchenault, Gautier; Jarry, Patrick; Locci, Elizabeth; Malcles, Julie; Rander, John; Rosowsky, André; Titov, Maksym; Baffioni, Stephanie; Beaudette, Florian; Busson, Philippe; Charlot, Claude; Dahms, Torsten; Dalchenko, Mykhailo; Dobrzynski, Ludwik; Filipovic, Nicolas; Florent, Alice; 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Nugent, Ian Michael; Perchalla, Lars; Pooth, Oliver; Stahl, Achim; Asin, Ivan; Bartosik, Nazar; Behr, Joerg; Behrenhoff, Wolf; Behrens, Ulf; Bell, Alan James; Bergholz, Matthias; Bethani, Agni; Borras, Kerstin; Burgmeier, Armin; Cakir, Altan; Calligaris, Luigi; Campbell, Alan; Choudhury, Somnath; Costanza, Francesco; Diez Pardos, Carmen; Dooling, Samantha; Dorland, Tyler; Eckerlin, Guenter; Eckstein, Doris; Eichhorn, Thomas; Flucke, Gero; Garay Garcia, Jasone; Geiser, Achim; Gunnellini, Paolo; Hauk, Johannes; Hempel, Maria; Horton, Dean; Jung, Hannes; Kalogeropoulos, Alexis; Kasemann, Matthias; Katsas, Panagiotis; Kieseler, Jan; Kleinwort, Claus; Krücker, Dirk; Lange, Wolfgang; Leonard, Jessica; Lipka, Katerina; Lobanov, Artur; Lohmann, Wolfgang; Lutz, Benjamin; Mankel, Rainer; Marfin, Ihar; Melzer-Pellmann, Isabell-Alissandra; Meyer, Andreas Bernhard; Mittag, Gregor; Mnich, Joachim; Mussgiller, Andreas; Naumann-Emme, Sebastian; Nayak, Aruna; Novgorodova, Olga; Nowak, Friederike; Ntomari, Eleni; Perrey, Hanno; Pitzl, Daniel; Placakyte, Ringaile; Raspereza, Alexei; Ribeiro Cipriano, Pedro M; Ron, Elias; Sahin, Mehmet Özgür; Salfeld-Nebgen, Jakob; Saxena, Pooja; Schmidt, Ringo; Schoerner-Sadenius, Thomas; Schröder, Matthias; Seitz, Claudia; Spannagel, Simon; Vargas Trevino, Andrea Del Rocio; Walsh, Roberval; Wissing, Christoph; Aldaya Martin, Maria; Blobel, Volker; Centis Vignali, Matteo; Draeger, Arne-Rasmus; Erfle, Joachim; Garutti, Erika; Goebel, Kristin; Görner, Martin; Haller, Johannes; Hoffmann, Malte; Höing, Rebekka Sophie; Kirschenmann, Henning; Klanner, Robert; Kogler, Roman; Lange, Jörn; Lapsien, Tobias; Lenz, Teresa; Marchesini, Ivan; Ott, Jochen; Peiffer, Thomas; Pietsch, Niklas; Poehlsen, Jennifer; Pöhlsen, Thomas; Rathjens, Denis; Sander, Christian; Schettler, Hannes; Schleper, Peter; Schlieckau, Eike; Schmidt, Alexander; Seidel, Markus; Sola, Valentina; Stadie, Hartmut; Steinbrück, Georg; Troendle, Daniel; Usai, Emanuele; Vanelderen, Lukas; Barth, Christian; Baus, Colin; Berger, Joram; Böser, Christian; Butz, Erik; Chwalek, Thorsten; De Boer, Wim; Descroix, Alexis; Dierlamm, Alexander; Feindt, Michael; Frensch, Felix; Giffels, Manuel; Hartmann, Frank; Hauth, Thomas; Husemann, Ulrich; Katkov, Igor; Kornmayer, Andreas; Kuznetsova, Ekaterina; Lobelle Pardo, Patricia; Mozer, Matthias Ulrich; Müller, Thomas; Nürnberg, Andreas; Quast, Gunter; Rabbertz, Klaus; Ratnikov, Fedor; Röcker, Steffen; Simonis, Hans-Jürgen; Stober, Fred-Markus Helmut; Ulrich, Ralf; Wagner-Kuhr, Jeannine; Wayand, Stefan; Weiler, Thomas; Wolf, Roger; Anagnostou, Georgios; Daskalakis, Georgios; Geralis, Theodoros; Giakoumopoulou, Viktoria Athina; Kyriakis, Aristotelis; Loukas, Demetrios; Markou, Athanasios; Markou, Christos; Psallidas, Andreas; Topsis-Giotis, Iasonas; Kesisoglou, Stilianos; Panagiotou, Apostolos; Saoulidou, Niki; Stiliaris, Efstathios; Aslanoglou, Xenofon; Evangelou, Ioannis; Flouris, Giannis; Foudas, Costas; Kokkas, Panagiotis; Manthos, Nikolaos; Papadopoulos, Ioannis; Paradas, Evangelos; Bencze, Gyorgy; Hajdu, Csaba; Hidas, Pàl; Horvath, Dezso; Sikler, Ferenc; Veszpremi, Viktor; Vesztergombi, Gyorgy; Zsigmond, Anna Julia; Beni, Noemi; Czellar, Sandor; Karancsi, János; Molnar, Jozsef; Palinkas, Jozsef; Szillasi, Zoltan; Raics, Peter; Trocsanyi, Zoltan Laszlo; Ujvari, Balazs; Swain, Sanjay Kumar; Beri, Suman Bala; Bhatnagar, Vipin; Dhingra, Nitish; Gupta, Ruchi; Bhawandeep, Bhawandeep; Kalsi, Amandeep Kaur; Kaur, Manjit; Mittal, Monika; Nishu, Nishu; Singh, Jasbir; Kumar, Ashok; Kumar, Arun; Ahuja, Sudha; Bhardwaj, Ashutosh; Choudhary, Brajesh C; Kumar, Ajay; Malhotra, Shivali; Naimuddin, Md; Ranjan, Kirti; Sharma, Varun; Banerjee, Sunanda; Bhattacharya, Satyaki; Chatterjee, Kalyanmoy; Dutta, Suchandra; Gomber, Bhawna; Jain, Sandhya; Jain, Shilpi; Khurana, Raman; Modak, Atanu; Mukherjee, Swagata; Roy, Debarati; Sarkar, Subir; Sharan, Manoj; Abdulsalam, Abdulla; Dutta, Dipanwita; Kailas, Swaminathan; Kumar, Vineet; Mohanty, Ajit Kumar; Pant, Lalit Mohan; 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Silvestris, Lucia; Singh, Gurpreet; Venditti, Rosamaria; Verwilligen, Piet; Zito, Giuseppe; Abbiendi, Giovanni; Benvenuti, Alberto; Bonacorsi, Daniele; Braibant-Giacomelli, Sylvie; Brigliadori, Luca; Campanini, Renato; Capiluppi, Paolo; Castro, Andrea; Cavallo, Francesca Romana; Codispoti, Giuseppe; Cuffiani, Marco; Dallavalle, Gaetano-Marco; Fabbri, Fabrizio; Fanfani, Alessandra; Fasanella, Daniele; Giacomelli, Paolo; Grandi, Claudio; Guiducci, Luigi; Marcellini, Stefano; Masetti, Gianni; Montanari, Alessandro; Navarria, Francesco; Perrotta, Andrea; Primavera, Federica; Rossi, Antonio; Rovelli, Tiziano; Siroli, Gian Piero; Tosi, Nicolò; Travaglini, Riccardo; Albergo, Sebastiano; Cappello, Gigi; Chiorboli, Massimiliano; Costa, Salvatore; Giordano, Ferdinando; Potenza, Renato; Tricomi, Alessia; Tuve, Cristina; Barbagli, Giuseppe; Ciulli, Vitaliano; Civinini, Carlo; D'Alessandro, Raffaello; Focardi, Ettore; Gallo, Elisabetta; Gonzi, Sandro; Gori, Valentina; Lenzi, Piergiulio; Meschini, Marco; Paoletti, Simone; Sguazzoni, Giacomo; Tropiano, Antonio; Benussi, Luigi; Bianco, Stefano; Fabbri, Franco; Piccolo, Davide; Ferro, Fabrizio; Lo Vetere, Maurizio; Robutti, Enrico; Tosi, Silvano; Dinardo, Mauro Emanuele; Fiorendi, Sara; Gennai, Simone; Gerosa, Raffaele; Ghezzi, Alessio; Govoni, Pietro; Lucchini, Marco Toliman; Malvezzi, Sandra; Manzoni, Riccardo Andrea; Martelli, Arabella; Marzocchi, Badder; Menasce, Dario; Moroni, Luigi; Paganoni, Marco; Pedrini, Daniele; Ragazzi, Stefano; Redaelli, Nicola; Tabarelli de Fatis, Tommaso; Buontempo, Salvatore; Cavallo, Nicola; Di Guida, Salvatore; Fabozzi, Francesco; Iorio, Alberto Orso Maria; Lista, Luca; Meola, Sabino; Merola, Mario; Paolucci, Pierluigi; Azzi, Patrizia; Bacchetta, Nicola; Bisello, Dario; Branca, Antonio; Carlin, Roberto; Checchia, Paolo; Dall'Osso, Martino; Dorigo, Tommaso; Dosselli, Umberto; Galanti, Mario; Gasparini, Fabrizio; Gasparini, Ugo; Giubilato, Piero; Gonella, Franco; Gozzelino, Andrea; Kanishchev, Konstantin; Lacaprara, Stefano; Margoni, Martino; Montecassiano, Fabio; Pazzini, Jacopo; Pozzobon, Nicola; Ronchese, Paolo; Simonetto, Franco; Tosi, Mia; Zotto, Pierluigi; Zucchetta, Alberto; Zumerle, Gianni; Gabusi, Michele; Ratti, Sergio P; Riccardi, Cristina; Salvini, Paola; Vitulo, Paolo; Biasini, Maurizio; Bilei, Gian Mario; Ciangottini, Diego; Fanò, Livio; Lariccia, Paolo; Mantovani, Giancarlo; Menichelli, Mauro; Romeo, Francesco; Saha, Anirban; Santocchia, Attilio; Spiezia, Aniello; Androsov, Konstantin; Azzurri, Paolo; Bagliesi, Giuseppe; Bernardini, Jacopo; Boccali, Tommaso; Broccolo, Giuseppe; Castaldi, Rino; Ciocci, Maria Agnese; Dell'Orso, Roberto; Donato, Silvio; Fiori, Francesco; Foà, Lorenzo; Giassi, Alessandro; Grippo, Maria Teresa; Ligabue, Franco; Lomtadze, Teimuraz; Martini, Luca; Messineo, Alberto; Moon, Chang-Seong; Palla, Fabrizio; Rizzi, Andrea; Savoy-Navarro, Aurore; Serban, Alin Titus; Spagnolo, Paolo; Squillacioti, Paola; Tenchini, Roberto; Tonelli, Guido; Venturi, Andrea; Verdini, Piero Giorgio; Vernieri, Caterina; Barone, Luciano; Cavallari, Francesca; D'imperio, Giulia; Del Re, Daniele; Diemoz, Marcella; Grassi, Marco; Jorda, Clara; Longo, Egidio; Margaroli, Fabrizio; Meridiani, Paolo; Micheli, Francesco; Nourbakhsh, Shervin; Organtini, Giovanni; Paramatti, Riccardo; Rahatlou, Shahram; Rovelli, Chiara; Santanastasio, Francesco; Soffi, Livia; Traczyk, Piotr; Amapane, Nicola; Arcidiacono, Roberta; Argiro, Stefano; Arneodo, Michele; Bellan, Riccardo; Biino, Cristina; Cartiglia, Nicolo; Casasso, Stefano; Costa, Marco; Degano, Alessandro; Demaria, Natale; Dujany, Giulio; Finco, Linda; Mariotti, Chiara; Maselli, Silvia; Migliore, Ernesto; Monaco, Vincenzo; Musich, Marco; Obertino, Maria Margherita; Ortona, Giacomo; Pacher, Luca; Pastrone, Nadia; Pelliccioni, Mario; Pinna Angioni, Gian Luca; Potenza, Alberto; Romero, Alessandra; Ruspa, Marta; Sacchi, Roberto; Solano, Ada; Staiano, Amedeo; Tamponi, Umberto; Belforte, Stefano; Candelise, Vieri; Casarsa, Massimo; Cossutti, Fabio; Della Ricca, Giuseppe; Gobbo, Benigno; La Licata, Chiara; Marone, Matteo; Montanino, Damiana; Schizzi, Andrea; Umer, Tomo; Zanetti, Anna; Chang, Sunghyun; Kropivnitskaya, Anna; Nam, Soon-Kwon; Kim, Dong Hee; Kim, Gui Nyun; Kim, Min Suk; Kong, Dae Jung; Lee, Sangeun; Oh, Young Do; Park, Hyangkyu; Sakharov, Alexandre; Son, Dong-Chul; Kim, Tae Jeong; Kim, Jae Yool; Song, Sanghyeon; Choi, Suyong; Gyun, Dooyeon; Hong, Byung-Sik; Jo, Mihee; Kim, Hyunchul; Kim, Yongsun; Lee, Byounghoon; Lee, Kyong Sei; Park, Sung Keun; Roh, Youn; Choi, Minkyoo; Kim, Ji Hyun; Park, Inkyu; Park, Sangnam; Ryu, Geonmo; Ryu, Min Sang; Choi, Young-Il; Choi, Young Kyu; Goh, Junghwan; Kim, Donghyun; Kwon, Eunhyang; Lee, Jongseok; Seo, Hyunkwan; Yu, Intae; Juodagalvis, Andrius; Komaragiri, Jyothsna Rani; Md Ali, Mohd Adli Bin; Castilla-Valdez, Heriberto; De La Cruz-Burelo, Eduard; Heredia-de La Cruz, Ivan; Lopez-Fernandez, Ricardo; Sánchez Hernández, Alberto; Carrillo Moreno, Salvador; Vazquez Valencia, Fabiola; Pedraza, Isabel; Salazar Ibarguen, Humberto Antonio; Casimiro Linares, Edgar; Morelos Pineda, Antonio; Krofcheck, David; Butler, Philip H; Reucroft, Steve; Ahmad, Ashfaq; Ahmad, Muhammad; Hassan, Qamar; Hoorani, Hafeez R; Khalid, Shoaib; Khan, Wajid Ali; Khurshid, Taimoor; Shah, Mehar Ali; Shoaib, Muhammad; Bialkowska, Helena; Bluj, Michal; Boimska, Bożena; Frueboes, Tomasz; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Zalewski, Piotr; Brona, Grzegorz; Bunkowski, Karol; Cwiok, Mikolaj; Dominik, Wojciech; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Misiura, Maciej; Olszewski, Michał; Wolszczak, Weronika; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Nguyen, Federico; Rodrigues Antunes, Joao; Seixas, Joao; Varela, Joao; Vischia, Pietro; Golutvin, Igor; Gorbunov, Ilya; Karjavin, Vladimir; Konoplyanikov, Viktor; Korenkov, Vladimir; Lanev, Alexander; Malakhov, Alexander; Matveev, Viktor; Mitsyn, Valeri Valentinovitch; Moisenz, Petr; Palichik, Vladimir; Perelygin, Victor; Shmatov, Sergey; Skatchkov, Nikolai; Smirnov, Vitaly; Tikhonenko, Elena; Yuldashev, Bekhzod S; Zarubin, Anatoli; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Levchenko, Petr; Murzin, Victor; Oreshkin, Vadim; Smirnov, Igor; Sulimov, Valentin; Uvarov, Lev; Vavilov, Sergey; Vorobyev, Alexey; Vorobyev, Andrey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Kirsanov, Mikhail; Krasnikov, Nikolai; Pashenkov, Anatoli; Tlisov, Danila; Toropin, Alexander; Epshteyn, Vladimir; Gavrilov, Vladimir; Lychkovskaya, Natalia; Popov, Vladimir; Safronov, Grigory; Semenov, Sergey; Spiridonov, Alexander; Stolin, Viatcheslav; Vlasov, Evgueni; Zhokin, Alexander; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Mesyats, Gennady; Rusakov, Sergey V; Vinogradov, Alexey; Belyaev, Andrey; Boos, Edouard; Dubinin, Mikhail; Dudko, Lev; Ershov, Alexander; Gribushin, Andrey; Klyukhin, Vyacheslav; Kodolova, Olga; Lokhtin, Igor; Obraztsov, Stepan; Petrushanko, Sergey; Savrin, Viktor; Snigirev, Alexander; Azhgirey, Igor; Bayshev, Igor; Bitioukov, Sergei; Kachanov, Vassili; Kalinin, Alexey; Konstantinov, Dmitri; Krychkine, Victor; Petrov, Vladimir; Ryutin, Roman; Sobol, Andrei; Tourtchanovitch, Leonid; Troshin, Sergey; Tyurin, Nikolay; Uzunian, Andrey; Volkov, Alexey; Adzic, Petar; Ekmedzic, Marko; Milosevic, Jovan; Rekovic, Vladimir; Alcaraz Maestre, Juan; Battilana, Carlo; Calvo, Enrique; Cerrada, Marcos; Chamizo Llatas, Maria; Colino, Nicanor; De La Cruz, Begona; Delgado Peris, Antonio; Domínguez Vázquez, Daniel; Escalante Del Valle, Alberto; Fernandez Bedoya, Cristina; Fernández Ramos, Juan Pablo; Flix, Jose; Fouz, Maria Cruz; Garcia-Abia, Pablo; Gonzalez Lopez, Oscar; Goy Lopez, Silvia; Hernandez, Jose M; Josa, Maria Isabel; Merino, Gonzalo; Navarro De Martino, Eduardo; Pérez Calero Yzquierdo, Antonio María; Puerta Pelayo, Jesus; Quintario Olmeda, Adrián; Redondo, Ignacio; Romero, Luciano; Senghi Soares, Mara; Albajar, Carmen; de Trocóniz, Jorge F; Missiroli, Marino; Moran, Dermot; Brun, Hugues; Cuevas, Javier; Fernandez Menendez, Javier; Folgueras, Santiago; Gonzalez Caballero, Isidro; Lloret Iglesias, Lara; Brochero Cifuentes, Javier Andres; Cabrillo, Iban Jose; Calderon, Alicia; Duarte Campderros, Jordi; Fernandez, Marcos; Gomez, Gervasio; Graziano, Alberto; Lopez Virto, Amparo; Marco, Jesus; Marco, Rafael; Martinez Rivero, Celso; Matorras, Francisco; Munoz Sanchez, Francisca Javiela; Piedra Gomez, Jonatan; Rodrigo, Teresa; Rodríguez-Marrero, Ana Yaiza; Ruiz-Jimeno, Alberto; Scodellaro, Luca; Vila, Ivan; Vilar Cortabitarte, Rocio; Abbaneo, Duccio; Auffray, Etiennette; Auzinger, Georg; Bachtis, Michail; Baillon, Paul; Ball, Austin; Barney, David; Benaglia, Andrea; Bendavid, Joshua; Benhabib, Lamia; Benitez, Jose F; Bernet, Colin; Bianchi, Giovanni; Bloch, Philippe; Bocci, Andrea; Bonato, Alessio; Bondu, Olivier; Botta, Cristina; Breuker, Horst; Camporesi, Tiziano; Cerminara, Gianluca; Colafranceschi, Stefano; D'Alfonso, Mariarosaria; D'Enterria, David; Dabrowski, Anne; David Tinoco Mendes, Andre; De Guio, Federico; De Roeck, Albert; De Visscher, Simon; Dobson, Marc; Dordevic, Milos; Dupont-Sagorin, Niels; Elliott-Peisert, Anna; Eugster, Jürg; Franzoni, Giovanni; Funk, Wolfgang; Gigi, Dominique; Gill, Karl; Giordano, Domenico; Girone, Maria; Glege, Frank; Guida, Roberto; Gundacker, Stefan; Guthoff, Moritz; Hammer, Josef; Hansen, Magnus; Harris, Philip; Hegeman, Jeroen; Innocente, Vincenzo; Janot, Patrick; Kousouris, Konstantinos; Krajczar, Krisztian; Lecoq, Paul; Lourenco, Carlos; Magini, Nicolo; Malgeri, Luca; Mannelli, Marcello; Marrouche, Jad; Masetti, Lorenzo; Meijers, Frans; Mersi, Stefano; Meschi, Emilio; Moortgat, Filip; Morovic, Srecko; Mulders, Martijn; Musella, Pasquale; Orsini, Luciano; Pape, Luc; Perez, Emmanuelle; Perrozzi, Luca; Petrilli, Achille; Petrucciani, Giovanni; Pfeiffer, Andreas; Pierini, Maurizio; Pimiä, Martti; Piparo, Danilo; Plagge, Michael; Racz, Attila; Rolandi, Gigi; Rovere, Marco; Sakulin, Hannes; Schäfer, Christoph; Schwick, Christoph; Sharma, Archana; Siegrist, Patrice; Silva, Pedro; Simon, Michal; Sphicas, Paraskevas; Spiga, Daniele; Steggemann, Jan; Stieger, Benjamin; Stoye, Markus; Treille, Daniel; Tsirou, Andromachi; Veres, Gabor Istvan; Vlimant, Jean-Roch; Wardle, Nicholas; Wöhri, Hermine Katharina; Wollny, Heiner; Zeuner, Wolfram Dietrich; Bertl, Willi; Deiters, Konrad; Erdmann, Wolfram; Horisberger, Roland; Ingram, Quentin; Kaestli, Hans-Christian; Kotlinski, Danek; Langenegger, Urs; Renker, Dieter; Rohe, Tilman; Bachmair, Felix; Bäni, Lukas; Bianchini, Lorenzo; Bortignon, Pierluigi; Buchmann, Marco-Andrea; Casal, Bruno; Chanon, Nicolas; Deisher, Amanda; Dissertori, Günther; Dittmar, Michael; Donegà, Mauro; Dünser, Marc; Eller, Philipp; Grab, Christoph; Hits, Dmitry; Lustermann, Werner; Mangano, Boris; Marini, Andrea Carlo; Martinez Ruiz del Arbol, Pablo; Meister, Daniel; Mohr, Niklas; Nägeli, Christoph; Nessi-Tedaldi, Francesca; Pandolfi, Francesco; Pauss, Felicitas; Peruzzi, Marco; Quittnat, Milena; Rebane, Liis; Rossini, Marco; Starodumov, Andrei; Takahashi, Maiko; Theofilatos, Konstantinos; Wallny, Rainer; Weber, Hannsjoerg Artur; Amsler, Claude; Canelli, Maria Florencia; Chiochia, Vincenzo; De Cosa, Annapaola; Hinzmann, Andreas; Hreus, Tomas; Kilminster, Benjamin; Lange, Clemens; Millan Mejias, Barbara; Ngadiuba, Jennifer; Robmann, Peter; Ronga, Frederic Jean; Taroni, Silvia; Verzetti, Mauro; Yang, Yong; Cardaci, Marco; Chen, Kuan-Hsin; Ferro, Cristina; Kuo, Chia-Ming; Lin, Willis; Lu, Yun-Ju; Volpe, Roberta; Yu, Shin-Shan; Chang, Paoti; Chang, You-Hao; Chang, Yu-Wei; Chao, Yuan; Chen, Kai-Feng; Chen, Po-Hsun; Dietz, Charles; Grundler, Ulysses; Hou, George Wei-Shu; Kao, Kai-Yi; Lei, Yeong-Jyi; Liu, Yueh-Feng; Lu, Rong-Shyang; Majumder, Devdatta; Petrakou, Eleni; Tzeng, Yeng-Ming; Wilken, Rachel; Asavapibhop, Burin; Srimanobhas, Norraphat; Suwonjandee, Narumon; Adiguzel, Aytul; Bakirci, Mustafa Numan; Cerci, Salim; Dozen, Candan; Dumanoglu, Isa; Eskut, Eda; Girgis, Semiray; Gokbulut, Gul; Gurpinar, Emine; Hos, Ilknur; Kangal, Evrim Ersin; Kayis Topaksu, Aysel; Onengut, Gulsen; Ozdemir, Kadri; Ozturk, Sertac; Polatoz, Ayse; Sogut, Kenan; Sunar Cerci, Deniz; Tali, Bayram; Topakli, Huseyin; Vergili, Mehmet; Akin, Ilina Vasileva; Bilin, Bugra; Bilmis, Selcuk; Gamsizkan, Halil; Karapinar, Guler; Ocalan, Kadir; Sekmen, Sezen; Surat, Ugur Emrah; Yalvac, Metin; Zeyrek, Mehmet; Gülmez, Erhan; Isildak, Bora; Kaya, Mithat; Kaya, Ozlem; Bahtiyar, Hüseyin; Barlas, Esra; Cankocak, Kerem; Vardarli, Fuat Ilkehan; Yücel, Mete; Levchuk, Leonid; Sorokin, Pavel; Brooke, James John; Clement, Emyr; Cussans, David; Flacher, Henning; Frazier, Robert; Goldstein, Joel; Grimes, Mark; Heath, Greg P; Heath, Helen F; Jacob, Jeson; Kreczko, Lukasz; Lucas, Chris; Meng, Zhaoxia; Newbold, Dave M; Paramesvaran, Sudarshan; Poll, Anthony; Senkin, Sergey; Smith, Vincent J; Williams, Thomas; Bell, Ken W; Belyaev, Alexander; Brew, Christopher; Brown, Robert M; Cockerill, David JA; Coughlan, John A; Harder, Kristian; Harper, Sam; Olaiya, Emmanuel; Petyt, David; Shepherd-Themistocleous, Claire; Thea, Alessandro; Tomalin, Ian R; Womersley, William John; Worm, Steven; Baber, Mark; Bainbridge, Robert; Buchmuller, Oliver; Burton, Darren; Colling, David; Cripps, Nicholas; Cutajar, Michael; Dauncey, Paul; Davies, Gavin; Della Negra, Michel; Dunne, Patrick; Ferguson, William; Fulcher, Jonathan; Futyan, David; Gilbert, Andrew; Hall, Geoffrey; Iles, Gregory; Jarvis, Martyn; Karapostoli, Georgia; Kenzie, Matthew; Lane, Rebecca; Lucas, Robyn; Lyons, Louis; Magnan, Anne-Marie; Malik, Sarah; Mathias, Bryn; Nash, Jordan; Nikitenko, Alexander; Pela, Joao; Pesaresi, Mark; Petridis, Konstantinos; Raymond, David Mark; Rogerson, Samuel; Rose, Andrew; Seez, Christopher; Sharp, Peter; Tapper, Alexander; Vazquez Acosta, Monica; Virdee, Tejinder; Cole, Joanne; Hobson, Peter R; Khan, Akram; Kyberd, Paul; Leggat, Duncan; Leslie, Dawn; Martin, William; Reid, Ivan; Symonds, Philip; Teodorescu, Liliana; Turner, Mark; Dittmann, Jay; Hatakeyama, Kenichi; Kasmi, Azeddine; Liu, Hongxuan; Scarborough, Tara; Charaf, Otman; Cooper, Seth; Henderson, Conor; Rumerio, Paolo; Avetisyan, Aram; Bose, Tulika; Fantasia, Cory; Lawson, Philip; Richardson, Clint; Rohlf, James; Sperka, David; St John, Jason; Sulak, Lawrence; Alimena, Juliette; Berry, Edmund; Bhattacharya, Saptaparna; Christopher, Grant; Cutts, David; Demiragli, Zeynep; Ferapontov, Alexey; Garabedian, Alex; Heintz, Ulrich; Kukartsev, Gennadiy; Laird, Edward; Landsberg, Greg; Luk, Michael; Narain, Meenakshi; Segala, Michael; Sinthuprasith, Tutanon; Speer, Thomas; Swanson, Joshua; Breedon, Richard; Breto, Guillermo; Calderon De La Barca Sanchez, Manuel; Chauhan, Sushil; Chertok, Maxwell; Conway, John; Conway, Rylan; Cox, Peter Timothy; Erbacher, Robin; Gardner, Michael; Ko, Winston; Lander, Richard; Miceli, Tia; Mulhearn, Michael; Pellett, Dave; Pilot, Justin; Ricci-Tam, Francesca; Searle, Matthew; Shalhout, Shalhout; Smith, John; Squires, Michael; Stolp, Dustin; Tripathi, Mani; Wilbur, Scott; Yohay, Rachel; Cousins, Robert; Everaerts, Pieter; Farrell, Chris; Hauser, Jay; Ignatenko, Mikhail; Rakness, Gregory; Takasugi, Eric; Valuev, Vyacheslav; Weber, Matthias; Babb, John; Burt, Kira; Clare, Robert; Ellison, John Anthony; Gary, J William; Hanson, Gail; Heilman, Jesse; Ivova Rikova, Mirena; Jandir, Pawandeep; Kennedy, Elizabeth; Lacroix, Florent; Liu, Hongliang; Long, Owen Rosser; Luthra, Arun; Malberti, Martina; Nguyen, Harold; Olmedo Negrete, Manuel; Shrinivas, Amithabh; Sumowidagdo, Suharyo; Wimpenny, Stephen; Andrews, Warren; Branson, James G; Cerati, Giuseppe Benedetto; Cittolin, Sergio; D'Agnolo, Raffaele Tito; Evans, David; Holzner, André; Kelley, Ryan; Klein, Daniel; Lebourgeois, Matthew; Letts, James; Macneill, Ian; Olivito, Dominick; Padhi, Sanjay; Palmer, Christopher; Pieri, Marco; Sani, Matteo; Sharma, Vivek; Simon, Sean; Sudano, Elizabeth; Tadel, Matevz; Tu, Yanjun; Vartak, Adish; Welke, Charles; Würthwein, Frank; Yagil, Avraham; Yoo, Jaehyeok; Barge, Derek; Bradmiller-Feld, John; Campagnari, Claudio; Danielson, Thomas; Dishaw, Adam; Flowers, Kristen; Franco Sevilla, Manuel; Geffert, Paul; George, Christopher; Golf, Frank; Gouskos, Loukas; Incandela, Joe; Justus, Christopher; Mccoll, Nickolas; Richman, Jeffrey; Stuart, David; To, Wing; West, Christopher; Apresyan, Artur; Bornheim, Adolf; Bunn, Julian; Chen, Yi; Di Marco, Emanuele; Duarte, Javier; Mott, Alexander; Newman, Harvey B; Pena, Cristian; Rogan, Christopher; Spiropulu, Maria; Timciuc, Vladlen; Wilkinson, Richard; Xie, Si; Zhu, Ren-Yuan; Azzolini, Virginia; Calamba, Aristotle; Carlson, Benjamin; Ferguson, Thomas; Iiyama, Yutaro; Paulini, Manfred; Russ, James; Vogel, Helmut; Vorobiev, Igor; Cumalat, John Perry; Ford, William T; Gaz, Alessandro; Luiggi Lopez, Eduardo; Nauenberg, Uriel; Smith, James; Stenson, Kevin; Ulmer, Keith; Wagner, Stephen Robert; Alexander, James; Chatterjee, Avishek; Chu, Jennifer; Dittmer, Susan; Eggert, Nicholas; Mirman, Nathan; Nicolas Kaufman, Gala; Patterson, Juliet Ritchie; Ryd, Anders; Salvati, Emmanuele; Skinnari, Louise; Sun, Werner; Teo, Wee Don; Thom, Julia; Thompson, Joshua; Tucker, Jordan; Weng, Yao; Winstrom, Lucas; Wittich, Peter; Winn, Dave; Abdullin, Salavat; Albrow, Michael; Anderson, Jacob; Apollinari, Giorgio; Bauerdick, Lothar AT; Beretvas, Andrew; Berryhill, Jeffrey; Bhat, Pushpalatha C; Burkett, Kevin; Butler, Joel Nathan; Cheung, Harry; Chlebana, Frank; Cihangir, Selcuk; Elvira, Victor Daniel; Fisk, Ian; Freeman, Jim; Gao, Yanyan; Gottschalk, Erik; Gray, Lindsey; Green, Dan; Grünendahl, Stefan; Gutsche, Oliver; Hanlon, Jim; Hare, Daryl; Harris, Robert M; Hirschauer, James; Hooberman, Benjamin; Jindariani, Sergo; Johnson, Marvin; Joshi, Umesh; Kaadze, Ketino; Klima, Boaz; Kreis, Benjamin; Kwan, Simon; Linacre, Jacob; Lincoln, Don; Lipton, Ron; Liu, Tiehui; Lykken, Joseph; Maeshima, Kaori; Marraffino, John Michael; Martinez Outschoorn, Verena Ingrid; Maruyama, Sho; Mason, David; McBride, Patricia; Mishra, Kalanand; Mrenna, Stephen; Musienko, Yuri; Nahn, Steve; Newman-Holmes, Catherine; O'Dell, Vivian; Prokofyev, Oleg; Sexton-Kennedy, Elizabeth; Sharma, Seema; Soha, Aron; Spalding, William J; Spiegel, Leonard; Taylor, Lucas; Tkaczyk, Slawek; Tran, Nhan Viet; Uplegger, Lorenzo; Vaandering, Eric Wayne; Vidal, Richard; Whitbeck, Andrew; Whitmore, Juliana; Yang, Fan; Acosta, Darin; Avery, Paul; Bourilkov, Dimitri; Carver, Matthew; Cheng, Tongguang; Curry, David; Das, Souvik; De Gruttola, Michele; Di Giovanni, Gian Piero; Field, Richard D; Fisher, Matthew; Furic, Ivan-Kresimir; Hugon, Justin; Konigsberg, Jacobo; Korytov, Andrey; Kypreos, Theodore; Low, Jia Fu; Matchev, Konstantin; Milenovic, Predrag; Mitselmakher, Guenakh; Muniz, Lana; Rinkevicius, Aurelijus; Shchutska, Lesya; Snowball, Matthew; Yelton, John; Zakaria, Mohammed; Hewamanage, Samantha; Linn, Stephan; Markowitz, Pete; Martinez, German; Rodriguez, Jorge Luis; Adams, Todd; Askew, Andrew; Bochenek, Joseph; Diamond, Brendan; Haas, Jeff; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Prosper, Harrison; Veeraraghavan, Venkatesh; Weinberg, Marc; Baarmand, Marc M; Hohlmann, Marcus; Kalakhety, Himali; Yumiceva, Francisco; Adams, Mark Raymond; Apanasevich, Leonard; Bazterra, Victor Eduardo; Berry, Douglas; Betts, Russell Richard; Bucinskaite, Inga; Cavanaugh, Richard; Evdokimov, Olga; Gauthier, Lucie; Gerber, Cecilia Elena; Hofman, David Jonathan; Khalatyan, Samvel; Kurt, Pelin; Moon, Dong Ho; O'Brien, Christine; Silkworth, Christopher; Turner, Paul; Varelas, Nikos; Albayrak, Elif Asli; Bilki, Burak; Clarida, Warren; Dilsiz, Kamuran; Duru, Firdevs; Haytmyradov, Maksat; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mestvirishvili, Alexi; Moeller, Anthony; Nachtman, Jane; Ogul, Hasan; Onel, Yasar; Ozok, Ferhat; Penzo, Aldo; Rahmat, Rahmat; Sen, Sercan; Tan, Ping; Tiras, Emrah; Wetzel, James; Yetkin, Taylan; Yi, Kai; Barnett, Bruce Arnold; Blumenfeld, Barry; Bolognesi, Sara; Fehling, David; Gritsan, Andrei; Maksimovic, Petar; Martin, Christopher; Swartz, Morris; Baringer, Philip; Bean, Alice; Benelli, Gabriele; Bruner, Christopher; Gray, Julia; Kenny III, Raymond Patrick; Malek, Magdalena; Murray, Michael; Noonan, Daniel; Sanders, Stephen; Sekaric, Jadranka; Stringer, Robert; Wang, Quan; Wood, Jeffrey Scott; Barfuss, Anne-Fleur; Chakaberia, Irakli; Ivanov, Andrew; Khalil, Sadia; Makouski, Mikhail; Maravin, Yurii; Saini, Lovedeep Kaur; Shrestha, Shruti; Skhirtladze, Nikoloz; Svintradze, Irakli; Gronberg, Jeffrey; Lange, David; Rebassoo, Finn; Wright, Douglas; Baden, Drew; Belloni, Alberto; Calvert, Brian; Eno, Sarah Catherine; Gomez, Jaime; Hadley, Nicholas John; Kellogg, Richard G; Kolberg, Ted; Lu, Ying; Marionneau, Matthieu; Mignerey, Alice; Pedro, Kevin; Skuja, Andris; Tonjes, Marguerite; Tonwar, Suresh C; Apyan, Aram; Barbieri, Richard; Bauer, Gerry; Busza, Wit; Cali, Ivan Amos; Chan, Matthew; Di Matteo, Leonardo; Dutta, Valentina; Gomez Ceballos, Guillelmo; Goncharov, Maxim; Gulhan, Doga; Klute, Markus; Lai, Yue Shi; Lee, Yen-Jie; Levin, Andrew; Luckey, Paul David; Ma, Teng; Paus, Christoph; Ralph, Duncan; Roland, Christof; Roland, Gunther; Stephans, George; Stöckli, Fabian; Sumorok, Konstanty; Velicanu, Dragos; Veverka, Jan; Wyslouch, Bolek; Yang, Mingming; Zanetti, Marco; Zhukova, Victoria; Dahmes, Bryan; Gude, Alexander; Kao, Shih-Chuan; Klapoetke, Kevin; Kubota, Yuichi; Mans, Jeremy; Pastika, Nathaniel; Rusack, Roger; Singovsky, Alexander; Tambe, Norbert; Turkewitz, Jared; Acosta, John Gabriel; Oliveros, Sandra; Avdeeva, Ekaterina; Bloom, Kenneth; Bose, Suvadeep; Claes, Daniel R; Dominguez, Aaron; Gonzalez Suarez, Rebeca; Keller, Jason; Knowlton, Dan; Kravchenko, Ilya; Lazo-Flores, Jose; Malik, Sudhir; Meier, Frank; Snow, Gregory R; Dolen, James; Godshalk, Andrew; Iashvili, Ia; Kharchilava, Avto; Kumar, Ashish; Rappoccio, Salvatore; Alverson, George; Barberis, Emanuela; Baumgartel, Darin; Chasco, Matthew; Haley, Joseph; Massironi, Andrea; Morse, David Michael; Nash, David; Orimoto, Toyoko; Trocino, Daniele; Wang, Ren-Jie; Wood, Darien; Zhang, Jinzhong; Hahn, Kristan Allan; Kubik, Andrew; Mucia, Nicholas; Odell, Nathaniel; Pollack, Brian; Pozdnyakov, Andrey; Schmitt, Michael Henry; Stoynev, Stoyan; Sung, Kevin; Velasco, Mayda; Won, Steven; Brinkerhoff, Andrew; Chan, Kwok Ming; Drozdetskiy, Alexey; Hildreth, Michael; Jessop, Colin; Karmgard, Daniel John; Kellams, Nathan; Lannon, Kevin; Luo, Wuming; Lynch, Sean; Marinelli, Nancy; Pearson, Tessa; Planer, Michael; Ruchti, Randy; Valls, Nil; Wayne, Mitchell; Wolf, Matthias; Woodard, Anna; Antonelli, Louis; Brinson, Jessica; Bylsma, Ben; Durkin, Lloyd Stanley; Flowers, Sean; Hill, Christopher; Hughes, Richard; Kotov, Khristian; Ling, Ta-Yung; Puigh, Darren; Rodenburg, Marissa; Smith, Geoffrey; Winer, Brian L; Wolfe, Homer; Wulsin, Howard Wells; Driga, Olga; Elmer, Peter; Hebda, Philip; Hunt, Adam; Koay, Sue Ann; Lujan, Paul; Marlow, Daniel; Medvedeva, Tatiana; Mooney, Michael; Olsen, James; Piroué, Pierre; Quan, Xiaohang; Saka, Halil; Stickland, David; Tully, Christopher; Werner, Jeremy Scott; Zenz, Seth Conrad; Zuranski, Andrzej; Brownson, Eric; Mendez, Hector; Ramirez Vargas, Juan Eduardo; Barnes, Virgil E; Benedetti, Daniele; Bolla, Gino; Bortoletto, Daniela; De Mattia, Marco; Hu, Zhen; Jha, Manoj; Jones, Matthew; Jung, Kurt; Kress, Matthew; Leonardo, Nuno; Lopes Pegna, David; Maroussov, Vassili; Merkel, Petra; Miller, David Harry; Neumeister, Norbert; Radburn-Smith, Benjamin Charles; Shi, Xin; Shipsey, Ian; Silvers, David; Svyatkovskiy, Alexey; Wang, Fuqiang; Xie, Wei; Xu, Lingshan; Yoo, Hwi Dong; Zablocki, Jakub; Zheng, Yu; Parashar, Neeti; Stupak, John; Adair, Antony; Akgun, Bora; Ecklund, Karl Matthew; Geurts, Frank JM; Li, Wei; Michlin, Benjamin; Padley, Brian Paul; Redjimi, Radia; Roberts, Jay; Zabel, James; Betchart, Burton; Bodek, Arie; Covarelli, Roberto; de Barbaro, Pawel; Demina, Regina; Eshaq, Yossof; Ferbel, Thomas; Garcia-Bellido, Aran; Goldenzweig, Pablo; Han, Jiyeon; Harel, Amnon; Khukhunaishvili, Aleko; Petrillo, Gianluca; Vishnevskiy, Dmitry; Ciesielski, Robert; Demortier, Luc; Goulianos, Konstantin; Lungu, Gheorghe; Mesropian, Christina; Arora, Sanjay; Barker, Anthony; Chou, John Paul; Contreras-Campana, Christian; Contreras-Campana, Emmanuel; Duggan, Daniel; Ferencek, Dinko; Gershtein, Yuri; Gray, Richard; Halkiadakis, Eva; Hidas, Dean; Kaplan, Steven; Lath, Amitabh; Panwalkar, Shruti; Park, Michael; Patel, Rishi; Salur, Sevil; Schnetzer, Steve; Somalwar, Sunil; Stone, Robert; Thomas, Scott; Thomassen, Peter; Walker, Matthew; Rose, Keith; Spanier, Stefan; York, Andrew; Bouhali, Othmane; Castaneda Hernandez, Alfredo; Eusebi, Ricardo; Flanagan, Will; Gilmore, Jason; Kamon, Teruki; Khotilovich, Vadim; Krutelyov, Vyacheslav; Montalvo, Roy; Osipenkov, Ilya; Pakhotin, Yuriy; Perloff, Alexx; Roe, Jeffrey; Rose, Anthony; Safonov, Alexei; Sakuma, Tai; Suarez, Indara; Tatarinov, Aysen; Akchurin, Nural; Cowden, Christopher; Damgov, Jordan; Dragoiu, Cosmin; Dudero, Phillip Russell; Faulkner, James; Kovitanggoon, Kittikul; Kunori, Shuichi; Lee, Sung Won; Libeiro, Terence; Volobouev, Igor; Appelt, Eric; Delannoy, Andrés G; Greene, Senta; Gurrola, Alfredo; Johns, Willard; Maguire, Charles; Mao, Yaxian; Melo, Andrew; Sharma, Monika; Sheldon, Paul; Snook, Benjamin; Tuo, Shengquan; Velkovska, Julia; Arenton, Michael Wayne; Boutle, Sarah; Cox, Bradley; Francis, Brian; Goodell, Joseph; Hirosky, Robert; Ledovskoy, Alexander; Li, Hengne; Lin, Chuanzhe; Neu, Christopher; Wood, John; Clarke, Christopher; Harr, Robert; Karchin, Paul Edmund; Kottachchi Kankanamge Don, Chamath; Lamichhane, Pramod; Sturdy, Jared; Belknap, Donald; Carlsmith, Duncan; Cepeda, Maria; Dasu, Sridhara; Dodd, Laura; Duric, Senka; Friis, Evan; Hall-Wilton, Richard; Herndon, Matthew; Hervé, Alain; Klabbers, Pamela; Lanaro, Armando; Lazaridis, Christos; Levine, Aaron; Loveless, Richard; Mohapatra, Ajit; Ojalvo, Isabel; Perry, Thomas; Pierro, Giuseppe Antonio; Polese, Giovanni; Ross, Ian; Sarangi, Tapas; Savin, Alexander; Smith, Wesley H; Vuosalo, Carl; Woods, Nathaniel

2015-04-09

A measurement of the production cross section ratio $\\sigma(\\chi_{b2}(1\\mathrm{P}))/ \\sigma(\\chi_{b1}(1\\mathrm{P}))$ is presented. The $\\chi_{b1}(1\\mathrm{P})$ and $\\chi_{b2}(1\\mathrm{P})$ bottomonium states, promptly produced in pp collisions at $\\sqrt{s}$= 8 TeV, are detected by the CMS experiment at the CERN LHC through their radiative decays $\\chi_{b1,2}(1\\mathrm{P}) \\rightarrow \\Upsilon(1\\mathrm{S}) + \\gamma$. The emitted photons are measured through their conversion to e$^+$e$^-$ pairs, whose reconstruction allows the two states to be resolved. The $\\Upsilon(1\\mathrm{S})$ is measured through its decay to two muons. An event sample corresponding to an integrated luminosity of 20.7 fb$^{-1}$ is used to measure the cross section ratio in a phase-space region defined by the photon pseudorapidity, |$\\eta^\\gamma$| < 1.0; the $\\Upsilon(1\\mathrm{S})$ rapidity, |$y^\\Upsilon$| < 1.5; and the $\\Upsilon(1\\mathrm{S})$ transverse momentum, 7 < $p_{\\mathrm{T}}^\\Upsilon$ < 40 GeV. The cross section ratio sh...

Torelli groups, extended Johnson homomorphisms, and new cycles on the moduli space of curves

DEFF Research Database (Denmark)

Morita, Shigeyuki; Penner, Robert

modulo N are derived for all N. Furthermore, the first Johnson homomorphism, which is defined from the classical Torelli group to the third exterior power of the homology of the surface, is shown to lift to an explicit canonical 1-cocycle of the Teichmueller space. The main tool for these results...... cocycle lifts of the higher Johnson homomorphisms....

GENERALIZED p-FORMS ELECTRODYNAMICS IN CLIFFORD SPACES

CERN Document Server

Castro, C

2003-01-01

Using Clifford algebraic methods we describe how to generalize Maxwell theory of Electrodynamics asociated with ordinary point-charges to a generalized Maxwell theory in Clifford spaces involving extended-charges and p-forms of arbitrary rank. Clifford algebras contain the appropriate algebraic-geometric features  to implement the principle of polydimensional transformations (branes of different dimensionality are rotated into each other) that could possibly lead to a proper formulation of string and M theory.

Challenges in Teaching Space Physics to Different Target Groups From Space Weather Forecasters to Heavy-weight Theorists

Science.gov (United States)

Koskinen, H. E.

2008-12-01

Plasma physics as the backbone of space physics is difficult and thus the space physics students need to have strong foundations in general physics, in particular in classical electrodynamics and thermodynamics, and master the basic mathematical tools for physicists. In many universities the number of students specializing in space physics at Master's and Doctoral levels is rather small and the students may have quite different preferences ranging from experimental approach to hard-core space plasma theory. This poses challenges in building up a study program that has both the variety and depth needed to motivate the best students to choose this field. At the University of Helsinki we require all beginning space physics students, regardless whether they enter the field as Master's or Doctoral degree students, to take a one-semester package consisting of plasma physics and its space applications. However, some compromises are necessary. For example, it is not at all clear, how thoroughly Landau damping should be taught at the first run or how deeply should the intricacies of collisionless reconnection be discussed. In both cases we have left the details to an optional course in advanced space physics, even with the risk that the student's appreciation of, e.g., reconnection may remain at the level of a magic wand. For learning experimental work, data analysis or computer simulations we have actively pursued arrangements for the Master's degree students to get a summer employments in active research groups, which usually lead to the Master's theses. All doctoral students are members of research groups and participate in experimental work, data analysis, simulation studies or theory development, or any combination of these. We emphasize strongly "learning by doing" all the way from the weekly home exercises during the lecture courses to the PhD theses which in Finland consist typically of 4-6 peer-reviewed articles with a comprehensive introductory part.

Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis.

Science.gov (United States)

Burghardt, Andrew J; Lee, Chan Hee; Kuo, Daniel; Majumdar, Sharmila; Imboden, John B; Link, Thomas M; Li, Xiaojuan

2013-12-01

In this technique development study, high-resolution peripheral quantitative computed tomography (HR-pQCT) was applied to non-invasively image and quantify 3D joint space morphology of the wrist and metacarpophalangeal (MCP) joints of patients with rheumatoid arthritis (RA). HR-pQCT imaging (82 μm voxel-size) of the dominant hand was performed in patients with diagnosed rheumatoid arthritis (RA, N = 16, age: 52.6 ± 12.8) and healthy controls (CTRL, N = 7, age: 50.1 ± 15.0). An automated computer algorithm was developed to segment wrist and MCP joint spaces. The 3D distance transformation method was applied to spatially map joint space width, and summarized by the mean joint space width (JSW), minimal and maximal JSW (JSW.MIN, JSW.MAX), asymmetry (JSW.AS), and distribution (JSW.SD)-a measure of joint space heterogeneity. In vivo precision was determined for each measure by calculating the smallest detectable difference (SDD) and root mean square coefficient of variation (RMSCV%) of repeat scans. Qualitatively, HR-pQCT images and pseudo-color JSW maps showed global joint space narrowing, as well as regional and focal abnormalities in RA patients. In patients with radiographic JSN at an MCP, JSW.SD was two-fold greater vs. CTRL (p 3D joint space morphology from HR-pQCT, could improve early detection of joint damage in rheumatological diseases.

Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling.

Science.gov (United States)

Gatfield, John; Monnier, Lucile; Studer, Rolf; Bolli, Martin H; Steiner, Beat; Nayler, Oliver

2014-07-01

The sphingosine-1-phosphate (S1P) type 1 receptor (S1P1R) is a novel therapeutic target in lymphocyte-mediated autoimmune diseases. S1P1 receptor desensitization caused by synthetic S1P1 receptor agonists prevents T-lymphocyte egress from secondary lymphoid organs into the circulation. The selective S1P1 receptor agonist ponesimod, which is in development for the treatment of autoimmune diseases, efficiently reduces peripheral lymphocyte counts and displays efficacy in animal models of autoimmune disease. Using ponesimod and the natural ligand S1P, we investigated the molecular mechanisms leading to different signaling, desensitization and trafficking behavior of S1P1 receptors. In recombinant S1P1 receptor-expressing cells, ponesimod and S1P triggered Gαi protein-mediated signaling and β-arrestin recruitment with comparable potency and efficiency, but only ponesimod efficiently induced intracellular receptor accumulation. In human umbilical vein endothelial cells (HUVEC), ponesimod and S1P triggered translocation of the endogenous S1P1 receptor to the Golgi compartment. However, only ponesimod treatment caused efficient surface receptor depletion, receptor accumulation in the Golgi and degradation. Impedance measurements in HUVEC showed that ponesimod induced only short-lived Gαi protein-mediated signaling followed by resistance to further stimulation, whereas S1P induced sustained Gαi protein-mediated signaling without desensitization. Inhibition of S1P lyase activity in HUVEC rendered S1P an efficient S1P1 receptor internalizing compound and abrogated S1P-mediated sustained signaling. This suggests that S1P lyase - by facilitating S1P1 receptor recycling - is essential for S1P-mediated sustained signaling, and that synthetic agonists are functional antagonists because they are not S1P lyase substrates. Copyright © 2014 Elsevier Inc. All rights reserved.

Real-space renormalization group approach to driven diffusive systems

Energy Technology Data Exchange (ETDEWEB)

Hanney, T [SUPA and School of Physics, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JZ (United Kingdom); Stinchcombe, R B [Theoretical Physics, 1 Keble Road, Oxford, OX1 3NP (United Kingdom)

2006-11-24

We introduce a real-space renormalization group procedure for driven diffusive systems which predicts both steady state and dynamic properties. We apply the method to the boundary driven asymmetric simple exclusion process and recover exact results for the steady state phase diagram, as well as the crossovers in the relaxation dynamics for each phase.

Real-space renormalization group approach to driven diffusive systems

International Nuclear Information System (INIS)

Hanney, T; Stinchcombe, R B

2006-01-01

We introduce a real-space renormalization group procedure for driven diffusive systems which predicts both steady state and dynamic properties. We apply the method to the boundary driven asymmetric simple exclusion process and recover exact results for the steady state phase diagram, as well as the crossovers in the relaxation dynamics for each phase

Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis

International Nuclear Information System (INIS)

Fujii, Yasuyuki; Ueda, Yasuji; Ohtake, Hidenori; Ono, Naoya; Takayama, Tetsuo; Nakazawa, Kiyoshi; Igarashi, Yasuyuki; Goitsuka, Ryo

2012-01-01

Highlights: ► The effect of a newly developed S1P 1 -selective antagonist on angiogenic responses. ► S1P 1 is a critical component of VEGF-related angiogenic responses. ► S1P 1 -selective antagonist showed in vitro activity to inhibit angiogenesis. ► S1P 1 -selective antagonist showed in vivo activity to inhibit angiogenesis. ► The efficacy of S1P 1 -selective antagonist for anti-cancer therapies. -- Abstract: Sphingosine 1-phosphate receptor type 1 (S1P 1 ) was shown to be essential for vascular maturation during embryonic development and it has been demonstrated that substantial crosstalk exists between S1P 1 and other pro-angiogenic growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor. We developed a novel S1P 1 -selective antagonist, TASP0277308, which is structurally unrelated to S1P as well as previously described S1P 1 antagonists. TASP0277308 inhibited S1P- as well as VEGF-induced cellular responses, including migration and proliferation of human umbilical vein endothelial cells. Furthermore, TASP0277308 effectively blocked a VEGF-induced tube formation in vitro and significantly suppressed tumor cell-induced angiogenesis in vivo. These findings revealed that S1P 1 is a critical component of VEGF-related angiogenic responses and also provide evidence for the efficacy of TASP0277308 for anti-cancer therapies.

Generation of symmetry coordinates for crystals using multiplier representations of the space groups

DEFF Research Database (Denmark)

Hansen, Flemming Yssing

1978-01-01

Symmetry coordinates play an important role in the normal-mode calculations of crystals. It is therefore of great importance to have a general method, which may be applied for any crystal at any wave vector, to generate these. The multiplier representations of the space groups as given by Kovalev...... and the projection-operator technique provide a basis for such a method. The method is illustrated for the nonsymmorphic D36 space group, and the theoretical background for the representations of space groups in general is reviewed and illustrated on the example above. It is desirable to perform the projection...... of symmetry coordinates in such a way that they may be used for as many wave vectors as possible. We discuss how to achieve this goal. The detailed illustrations should make it simple to apply the theory in any other case....

Co-Higgs bundles on P^1

OpenAIRE

Rayan, Steven

2010-01-01

Co-Higgs bundles are Higgs bundles in the sense of Simpson, but with Higgs fields that take values in the tangent bundle instead of the cotangent bundle. Given a vector bundle on P^1, we find necessary and sufficient conditions on its Grothendieck splitting for it to admit a stable Higgs field. We characterize the rank-2, odd-degree moduli space as a universal elliptic curve with a globally-defined equation. For ranks r=2,3,4, we explicitly verify the conjectural Betti numbers emerging from t...

A geometric renormalization group in discrete quantum space-time

International Nuclear Information System (INIS)

Requardt, Manfred

2003-01-01

We model quantum space-time on the Planck scale as dynamical networks of elementary relations or time dependent random graphs, the time dependence being an effect of the underlying dynamical network laws. We formulate a kind of geometric renormalization group on these (random) networks leading to a hierarchy of increasingly coarse-grained networks of overlapping lumps. We provide arguments that this process may generate a fixed limit phase, representing our continuous space-time on a mesoscopic or macroscopic scale, provided that the underlying discrete geometry is critical in a specific sense (geometric long range order). Our point of view is corroborated by a series of analytic and numerical results, which allow us to keep track of the geometric changes, taking place on the various scales of the resolution of space-time. Of particular conceptual importance are the notions of dimension of such random systems on the various scales and the notion of geometric criticality

Factors affecting buccal corridor space in Angle′s Class II Division 1 malocclusion

Directory of Open Access Journals (Sweden)

Rashmi Bhat

2014-01-01

Full Text Available Background and Objectives: Buccal corridor space has been thought of primarily in terms of maxillary width, but there is also evidence that they are heavily influenced by the antero-posterior position of maxilla. The present study was undertaken with an aim of evaluating and comparing the dental and skeletal factors related to buccal corridor space in individuals having Class I and Class II Division 1 malocclusions. Materials and Methods: A total of 80 subjects of which 40 were males and 40 were females in the age group of 20-30 years were selected as per inclusion criteria and were grouped as Group I having Class I malocclusion and as Group II having Class II malocclusions based on angle ANB. 12 linear and 2 angular cephalometric measurements and 4 study cast measurements were used to correlate with the buccal corridor linear ratio (BCLR, calculated on smile photograph using the Adobe Photoshop 7.0 software (Adobe Systems Inc., San Jose, California, USA. The data obtained was statistically evaluated using independent t-test and multiple linear regression analysis. Result: Buccal corridor space is larger in individuals with Class II Division 1 malocclusion when compared with individuals with Class I malocclusions. There exists a significant difference in buccal corridor space between males and females. Conclusion: The present study helps in establishing the correlation between certain factors and the amount of buccal corridor space in individuals having skeletal Class II pattern.

(1 + 1) Newton-Hooke group for the simple and damped harmonic oscillator

Science.gov (United States)

Brzykcy, Przemysław

2018-03-01

It is demonstrated that, in the framework of the orbit method, a simple and damped harmonic oscillator is indistinguishable at the level of an abstract Lie algebra. This opens a possibility for treating the dissipative systems within the orbit method. An in-depth analysis of the coadjoint orbits of the (1 + 1) dimensional Newton-Hooke group is presented. Furthermore, it is argued that the physical interpretation is carried by a specific realisation of the Lie algebra of smooth functions on a phase space rather than by an abstract Lie algebra.

Space-charge-mediated anomalous ferroelectric switching in P(VDF-TrEE) polymer films

KAUST Repository

Hu, Weijin

2014-11-12

We report on the switching dynamics of P(VDF-TrEE) copolymer devices and the realization of additional substable ferroelectric states via modulation of the coupling between polarizations and space charges. The space-charge-limited current is revealed to be the dominant leakage mechanism in such organic ferroelectric devices, and electrostatic interactions due to space charges lead to the emergence of anomalous ferroelectric loops. The reliable control of ferroelectric switching in P(VDF-TrEE) copolymers opens doors toward engineering advanced organic memories with tailored switching characteristics.

Validation of missed space-group symmetry in X-ray powder diffraction structures with dispersion-corrected density functional theory.

Science.gov (United States)

Hempler, Daniela; Schmidt, Martin U; van de Streek, Jacco

2017-08-01

More than 600 molecular crystal structures with correct, incorrect and uncertain space-group symmetry were energy-minimized with dispersion-corrected density functional theory (DFT-D, PBE-D3). For the purpose of determining the correct space-group symmetry the required tolerance on the atomic coordinates of all non-H atoms is established to be 0.2 Å. For 98.5% of 200 molecular crystal structures published with missed symmetry, the correct space group is identified; there are no false positives. Very small, very symmetrical molecules can end up in artificially high space groups upon energy minimization, although this is easily detected through visual inspection. If the space group of a crystal structure determined from powder diffraction data is ambiguous, energy minimization with DFT-D provides a fast and reliable method to select the correct space group.

The Picard group of the moduli space of r-Spin Riemann surfaces

DEFF Research Database (Denmark)

Randal-Williams, Oscar

2012-01-01

An r-Spin Riemann surface is a Riemann surface equipped with a choice of rth root of the (co)tangent bundle. We give a careful construction of the moduli space (orbifold) of r-Spin Riemann surfaces, and explain how to establish a Madsen–Weiss theorem for it. This allows us to prove the “Mumford...... conjecture” for these moduli spaces, but more interestingly allows us to compute their algebraic Picard groups (for g≥10, or g≥9 in the 2-Spin case). We give a complete description of these Picard groups, in terms of explicitly constructed line bundles....

On the structure of Selmer groups of $p$-ordinary modular forms over $\\mathbf{Z}_p$-extensions

OpenAIRE

Kidwell, Keenan

2016-01-01

We prove analogues of the major algebraic results of Greenberg-Vatsal for Selmer groups of $p$-ordinary newforms over $\\mathbf{Z}_p$-extensions which may be neither cyclotomic nor anticyclotomic, under a number of technical hypotheses, including a cotorsion assumption on the Selmer groups. The main complication which arises in our work is the possible presence of finite primes which can split completely in the $\\mathbf{Z}_p$-extension being considered, resulting in the local cohomology groups...

A primer on Hilbert space theory linear spaces, topological spaces, metric spaces, normed spaces, and topological groups

CERN Document Server

Alabiso, Carlo

2015-01-01

This book is an introduction to the theory of Hilbert space, a fundamental tool for non-relativistic quantum mechanics. Linear, topological, metric, and normed spaces are all addressed in detail, in a rigorous but reader-friendly fashion. The rationale for an introduction to the theory of Hilbert space, rather than a detailed study of Hilbert space theory itself, resides in the very high mathematical difficulty of even the simplest physical case. Within an ordinary graduate course in physics there is insufficient time to cover the theory of Hilbert spaces and operators, as well as distribution theory, with sufficient mathematical rigor. Compromises must be found between full rigor and practical use of the instruments. The book is based on the author's lessons on functional analysis for graduate students in physics. It will equip the reader to approach Hilbert space and, subsequently, rigged Hilbert space, with a more practical attitude. With respect to the original lectures, the mathematical flavor in all sub...

An introduction to data reduction: space-group determination, scaling and intensity statistics.

Science.gov (United States)

Evans, Philip R

2011-04-01

This paper presents an overview of how to run the CCP4 programs for data reduction (SCALA, POINTLESS and CTRUNCATE) through the CCP4 graphical interface ccp4i and points out some issues that need to be considered, together with a few examples. It covers determination of the point-group symmetry of the diffraction data (the Laue group), which is required for the subsequent scaling step, examination of systematic absences, which in many cases will allow inference of the space group, putting multiple data sets on a common indexing system when there are alternatives, the scaling step itself, which produces a large set of data-quality indicators, estimation of |F| from intensity and finally examination of intensity statistics to detect crystal pathologies such as twinning. An appendix outlines the scoring schemes used by the program POINTLESS to assign probabilities to possible Laue and space groups.

On reflexivity of random walks in a random environment on a metric space

International Nuclear Information System (INIS)

Rozikov, U.A.

2002-11-01

In this paper, we consider random walks in random environments on a countable metric space when jumps of the walks of the fractions are finite. The transfer probabilities of the random walk from x is an element of G (where G is the considering metric space) are defined by vector p(x) is an element of R k , k>1, where {p(x), x is an element of G} is the set of independent and indentically distributed random vectors. For the random walk, a sufficient condition of nonreflexivity is obtained. Examples for metric spaces Z d free groups and free product of finite numbers cyclic groups of the second order and some other metric spaces are considered. (author)

Comparative analysis between P1 and B1 equations for neutron moderation; Analise comparativa entre os metodos de obtencao e das solucoes das equacoes P1 e B1 para moderacao de neutrons

Energy Technology Data Exchange (ETDEWEB)

Martinez, Aquilino Senra; Silva, Fernando Carvalho da; Cardoso, Carlos Eduardo Santos [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Programa de Engenharia Nuclear

2000-07-01

In order to calculate the neutron flux in nuclear reactors, B1 or P1 equations are solved by numerical methods for several groups of energy. The neutron fluxes obtained from the solutions of the B1 and P1 equations are similar when they are applied to large nuclear power reactors. However, an important difference between the two fluxes is that the system of P1 equations uses one more approximation than the B1 system and then, its flux is less precise. The present work shows the relations between both equations and analyzes for what conditions the two equations systems are equivalent. Furthermore, this equations are numerically solved in 54 groups of energy for a quadrangular arrange. (author)

New alkali metal diphosphates how materials to preserve the security of the environment: CsNaCu(P2O7), Rb2Cu(P2O7) and CsNaCo(P2O7) synthesis and crystal structure determination

Science.gov (United States)

Chernyatieva, Anastasiya; Filatova, Alyona; Spiridonova, Dariya; Krivovichev, Sergey

2013-04-01

In this work we describe preliminary results of the synthesis and of a crystal-chemical study of synthetic phosphates with transition metals. Due to the increasing requirements for environmental safety specialists from various industries, we are searching for sustainable forms of immobilization of hazardous waste during storage. We are also developing a component-based waste for new materials. In our continued exploratory synthesis of compounds containing transition-metals, we were able to produce the new diphosphate phases CsNaCu(P2O7), Rb2Cu(P2O7) and CsNaCo(P2O7). A crystal chemical study has allowed us to identify new phosphates. Crystals of CsNaCu(P2O7) (Phase 1) is orthorhombic, crystallizes in space group Pmn21, with a = 5.147(8), b = 15.126(2), c = 9.717(2) Å, V = 756.20 Å3, R1 = 0.066 and Rb2Cu(P2O7) (Phase 2) is orthorhombic as well, crystallizes in space group Pmcn, with a = 5.183(8), b = 10.096(1), c = 15.146(3) Å, V = 793.55 Å3, R1 = 0.063, they have been obtained by high-temperature reaction of RbNO3, CsNO3, Cu(NO3)2, NaOH and (NH4)4P2O7. Synthetic crystals of the phosphate of copper and rubidium were studied in detail by us on the structures of Rb2Cu(P2O7) and Rb2Cu3(P2O7)2 - new alkali metal copper diphosphates (CHERNYATIEVA et al., 2008). Here we report the synthesis, the structure and the properties of the title compounds and we compare these phases with the previously discovered K2CuP2O7 (ELMAADI et al., 1995) and CsNaMnP2O7 (HUANG et al., 1998). These structures crystallize in other space groups, although their structures are also based on 2-D layers, formed by P2O7 groups combined with polyhedra of the transition metals (CHERNYATIEVA et al., 2012). A crystal chemical study has allowed us to identify even new diphosphates CsNaCu(P2O7) (Phase 3). Crystals of CsNaCoP2O7 is monoclinic, space group P 21/n, with a = 7,424(2), b = 7,648(1), c = 12,931(3)Å, β = 90,71(2)° , V = 734.2(3) Å3 and R1 = 0.060. The structure is based framework of Co

Future In-Space Operations (FISO): A Working Group and Community Engagement

Science.gov (United States)

Thronson, Harley; Lester, Dan

2013-01-01

Long-duration human capabilities beyond low Earth orbit (LEO), either in support of or as an alternative to lunar surface operations, have been assessed at least since the late 1960s. Over the next few months, we will present short histories of concepts for long-duration, free-space human habitation beyond LEO from the end of the Apollo program to the Decadal Planning Team (DPT)/NASA Exploration Team (NExT), which was active in 1999 2000 (see Forging a vision: NASA s Decadal Planning Team and the origins of the Vision for Space Exploration , The Space Review, December 19, 2005). Here we summarize the brief existence of the Future In-Space Operations (FISO) working group in 2005 2006 and its successor, a telecon-based colloquium series, which we co-moderate.

Space-time versus world-sheet renormalization group equation in string theory

International Nuclear Information System (INIS)

Brustein, R.; Roland, K.

1991-05-01

We discuss the relation between space-time renormalization group equation for closed string field theory and world-sheet renormalization group equation for first-quantized strings. Restricting our attention to massless states we argue that there is a one-to-one correspondence between the fixed point solutions of the two renormalization group equations. In particular, we show how to extract the Fischler-Susskind mechanism from the string field theory equation in the case of the bosonic string. (orig.)

HAMMER, 1-D Multigroup Neutron Transport Infinite System Cell Calculation for Few-Group Diffusion Calculation

International Nuclear Information System (INIS)

Honeck, H.C.

1984-01-01

1 - Description of problem or function: HAMMER performs infinite lattice, one-dimensional cell multigroup calculations, followed (optionally) by one-dimensional, few-group, multi-region reactor calculations with neutron balance edits. 2 - Method of solution: Infinite lattice parameters are calculated by means of multigroup transport theory, composite reactor parameters by few-group diffusion theory. 3 - Restrictions on the complexity of the problem: - Cell calculations - maxima of: 30 thermal groups; 54 epithermal groups; 20 space points; 20 regions; 18 isotopes; 10 mixtures; 3 thermal up-scattering mixtures; 200 resonances per group; no overlap or interference; single level only. - Reactor calculations - maxima of : 40 regions; 40 mixtures; 250 space points; 4 groups

The pMSSM Interpretation of LHC Results Using Rernormalization Group Invariants

Energy Technology Data Exchange (ETDEWEB)

Carena, Marcela [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Lykken, Joseph [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Sekmen, Sezen [CERN, Geneva (Switzerland); Shah, Nausheen R. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Wagner, Carlos E.M. [Enrico Fermi Institute, Univ. of Chicago, IL (United States)

2012-10-01

The LHC has started to constrain supersymmetry-breaking parameters by setting bounds on possible colored particles at the weak scale. Moreover, constraints from Higgs physics, flavor physics, the anomalous magnetic moment of the muon, as well as from searches at LEP and the Tevatron have set additional bounds on these parameters. Renormalization Group Invariants (RGIs) provide a very useful way of representing the allowed parameter space by making direct connection with the values of these parameters at the messenger scale. Using a general approach, based on the pMSSM parametrization of the soft supersymmetry-breaking parameters, we analyze the current experimental constraints to determine the probability distributions for the RGIs. As examples of their application, we use these distributions to analyze the question of Gaugino Mass Unification and to probabilistically determine the parameters of General and Minimal Gauge Mediation with arbitrary Higgs mass parameters at the Messenger Scale.

The pMSSM Interpretation of LHC Results Using Rernormalization Group Invariants

CERN Document Server

Carena, Marcela; Sekmen, Sezen; Shah, Nausheen R; Wagner, Carlos E M

2012-01-01

The LHC has started to constrain supersymmetry-breaking parameters by setting bounds on possible colored particles at the weak scale. Moreover, constraints from Higgs physics, flavor physics, the anomalous magnetic moment of the muon, as well as from searches at LEP and the Tevatron have set additional bounds on these parameters. Renormalization Group Invariants (RGIs) provide a very useful way of representing the allowed parameter space by making direct connection with the values of these parameters at the messenger scale. Using a general approach, based on the pMSSM parametrization of the soft supersymmetry-breaking parameters, we analyze the current experimental constraints to determine the probability distributions for the RGIs. As examples of their application, we use these distributions to analyze the question of Gaugino Mass Unification and to probabilistically determine the parameters of General and Minimal Gauge Mediation with arbitrary Higgs mass parameters at the Messenger Scale.

Mice in Bion-M 1 Space Mission: Training and Selection

Science.gov (United States)

Andreev-Andrievskiy, Alexander; Popova, Anfisa; Boyle, Richard; Alberts, Jeffrey; Shenkman, Boris; Vinogradova, Olga; Dolgov, Oleg; Anokhin, Konstantin; Tsvirkun, Darya; Soldatov, Pavel; Nemirovskaya, Tatyana; Ilyin, Eugeniy; Sychev, Vladimir

2014-01-01

After a 16-year hiatus, Russia has resumed its program of biomedical research in space, with the successful 30-day flight of the Bion-M 1 biosatellite (April 19–May 19, 2013). The principal species for biomedical research in this project was the mouse. This paper presents an overview of the scientific goals, the experimental design and the mouse training/selection program. The aim of mice experiments in the Bion-M 1 project was to elucidate cellular and molecular mechanisms, underlying the adaptation of key physiological systems to long-term exposure in microgravity. The studies with mice combined in vivo measurements, both in flight and post-flight (including continuous blood pressure measurement), with extensive in vitro studies carried out shortly after return of the mice and in the end of recovery study. Male C57/BL6 mice group housed in space habitats were flown aboard the Bion-M 1 biosatellite, or remained on ground in the control experiment that replicated environmental and housing conditions in the spacecraft. Vivarium control groups were used to account for housing effects and possible seasonal differences. Mice training included the co-adaptation in housing groups and mice adaptation to paste food diet. The measures taken to co-adapt aggressive male mice in housing groups and the peculiarities of “space” paste food are described. The training program for mice designated for in vivo studies was broader and included behavioral/functional test battery and continuous behavioral measurements in the home-cage. The results of the preliminary tests were used for the selection of homogenous groups. After the flight, mice were in good condition for biomedical studies and displayed signs of pronounced disadaptation to Earth's gravity. The outcomes of the training program for the mice welfare are discussed. We conclude that our training program was effective and that male mice can be successfully employed in space biomedical research. PMID:25133741

P-R-R Study Technique, Group Counselling And Gender Influence ...

African Journals Online (AJOL)

Read-Recall (P-R-R) study technique and group counselling on the academic performance of senior secondary school students. The objectives of this study were to determine the effect of Group Counselling combined with P-R-R study ...

On the phase space representations. 1

International Nuclear Information System (INIS)

Polubarinov, I.V.

1978-01-01

The Dirac representation theory deals usually with the amplitude formalism of the quantum theory. An introduction is given into a theory of some other representations, which are applicable in the density matrix formalism and can naturally be called phase space representations (PSR). They use terms of phase space variables (x and p simultaneously) and give a description, close to the classical phase space description. Definitions and algebraic properties are given in quantum mechanics for such PSRs as the Wigner representation, coherent state representation and others. Completeness relations of a matrix type are used as a starting point. The case of quantum field theory is also outlined

Expression of p53-regulated proteins in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight

International Nuclear Information System (INIS)

Takahashi, Akihisa; Suzuki, Hiromi; Shimazu, Toru; Omori, Katsunori; Ishioka, Noriaki; Ohnishi, Takeo; Seki, Masaya; Hashizume, Toko

2012-01-01

The aim of this study was to determine the biological effects of space radiations, microgravity, and the interaction of them on the expression of p53-regulated proteins. Space experiments were performed with two human cultured lymphoblastoid cell lines: one line (TSCE5) bears a wild-type p53 gene status, and another line (WTK1) bears a mutated p53 gene status. Under 1 gravity or microgravity conditions, the cells were grown in the cell biology experimental facility (CBEF) of the International Space Station for 8 days without experiencing the stress during launching and landing because the cells were frozen during these periods. Ground control samples were simultaneously cultured for 8 days in the CBEF on the ground for 8 days. After spaceflight, protein expression was analyzed using a Panorama TM Ab MicroArray protein chips. It was found that p53-dependent up-regulated proteins in response to space radiations and space environment were MeCP2 (methyl CpG binding protein 2), and Notch1 (Notch homolog 1), respectively. On the other hand, p53-dependent down-regulated proteins were TGF-β, TWEAKR (tumor necrosis factor-like weak inducer of apoptosis receptor), phosho-Pyk2 (Proline-rich tyrosine kinase 2), and 14-3-3θ/τ which were affected by microgravity, and DR4 (death receptor 4), PRMT1 (protein arginine methyltransferase 1) and ROCK-2 (Rho-associated, coiled-coil containing protein kinase 2) in response to space radiations. ROCK-2 was also suppressed in response to the space environment. The data provides the p53-dependent regulated proteins by exposure to space radiations and/or microgravity during spaceflight. Our expression data revealed proteins that might help to advance the basic space radiation biology. (author)

Neutron diffraction studies on Ca1-xBaxZr4P6O24 solid solutions

International Nuclear Information System (INIS)

Achary, S.N.; Jayakumar, O.D.; Patwe, S.J.; Kulshreshtha, S.K.; Tyagi, A.K.; Shinde, A.B.; Krishna, P.S.R.

2008-01-01

Herein we report the results of detailed crystallographic studies of Ca 1-x Ba x Zr 4 P 6 O 24 compositions from combined Rietveld refinements of powder X-ray and neutron diffraction data. All the studied compositions crystallize in rhombohedral lattice (space group R-3 No. 148). A continuous solid solution is concluded from the systematic variation of unit cell parameters. The variation of unit cell parameters with the composition indicates decreasing trend in α parameter with increasing Ba 2+ concentration contrast to an increasing trend in c parameter. (author)

Space Weather Activities of IONOLAB Group: IONOLAB-TEC

Science.gov (United States)

Arikan, F.; Sezen, U.; Arikan, O.; Ugurlu, O.; Nayir, H.

2009-04-01

Space Weather (SW) is the concept of changing environmental conditions in outer space and affect Earth and its technological systems. SW is a consequence of the solar activities and the coupling of solar energy on Earth's atmosphere due to the Earth's magnetic field. The monitoring and prediction of SW has utmost importance for HF communication, Satellite communication, navigation and guidance systems, Low Earth Orbit (LEO) satellite systems, Space Craft exit and entry into the atmosphere. Ionosphere is the plasma layer of the atmosphere that is ionized by solar radiation and it is a key player of SW. Ionosphere is a temporally and spatially varying, dispersive, anisotropic and inhomogeneous medium that is characterized primarily by its electron density distribution. IONOLAB is a group of researchers of various disciplines, getting together to handle challenges of the Earth's ionosphere. The team has researchers from Hacettepe University and Bilkent University, Department of Electrical and Electronics Engineering and General Command of Mapping of Turkish Army. One of the most important contributions of IONOLAB group is the automated web-based computation service for Total Electron Content (TEC). TEC corresponds to the line integral of electron density distribution on a given path. TEC can also be expressed as the amount of free electrons within 1 m2 cross-sectional area of the cylinder on the ray path. Global Position System (GPS) provides a cost-effective medium for monitoring of ionosphere using the signals recorded by stationary GPS receivers in estimating TEC. IONOLAB group has developed IONOLAB-TEC for reliable and robust estimates for all latitudes and both calm and disturbed days by using RINEX, IONEX and satellite ephemeris data provided from the IGS centers. IONOLAB-TEC consists of a regularized signal estimation algorithm which combines signals from all GPS satellites for a given instant and a given receiver, for a desired time period or for 24 hours

Identification, characterization and preliminary X-ray diffraction analysis of the rolling-circle replication initiator protein from plasmid pSTK1

International Nuclear Information System (INIS)

Carr, Stephen B.; Mecia, Lauren B.; Phillips, Simon E. V.; Thomas, Christopher D.

2013-01-01

A proteolytically stable fragment of a plasmid replication initiation protein from the thermophile G. stearothermophilus has been biochemically characterized, crystallized and diffraction data collected to a resolution of 2.5 Å. Antibiotic resistance in bacterial pathogens poses an ever-increasing risk to human health. In antibiotic-resistant strains of Staphylococcus aureus this resistance often resides in extra-chromosomal plasmids, such as those of the pT181 family, which replicate via a rolling-circle mechanism mediated by a plasmid-encoded replication initiation protein. Currently, there is no structural information available for the pT181-family Rep proteins. Here, the crystallization of a catalytically active fragment of a homologous replication initiation protein from the thermophile Geobacillus stearothermophilus responsible for the replication of plasmid pSTK1 is reported. Crystals of the RepSTK1 fragment diffracted to a resolution of 2.5 Å and belonged to space group P2 1 2 1 2 1

Self-dual phase space for (3 +1 )-dimensional lattice Yang-Mills theory

Science.gov (United States)

Riello, Aldo

2018-01-01

I propose a self-dual deformation of the classical phase space of lattice Yang-Mills theory, in which both the electric and magnetic fluxes take value in the compact gauge Lie group. A local construction of the deformed phase space requires the machinery of "quasi-Hamiltonian spaces" by Alekseev et al., which is reviewed here. The results is a full-fledged finite-dimensional and gauge-invariant phase space, the self-duality properties of which are largely enhanced in (3 +1 ) spacetime dimensions. This enhancement is due to a correspondence with the moduli space of an auxiliary noncommutative flat connection living on a Riemann surface defined from the lattice itself, which in turn equips the duality between electric and magnetic fluxes with a neat geometrical interpretation in terms of a Heegaard splitting of the space manifold. Finally, I discuss the consequences of the proposed deformation on the quantization of the phase space, its quantum gravitational interpretation, as well as its relevance for the construction of (3 +1 )-dimensional topological field theories with defects.

Blocking S1P interaction with S1P{sub 1} receptor by a novel competitive S1P{sub 1}-selective antagonist inhibits angiogenesis

Energy Technology Data Exchange (ETDEWEB)

Fujii, Yasuyuki, E-mail: y.fujii@po.rd.taisho.co.jp [Department of Molecular Function and Pharmacology Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Saitama, Saitama 331-9530 (Japan); Ueda, Yasuji; Ohtake, Hidenori; Ono, Naoya; Takayama, Tetsuo; Nakazawa, Kiyoshi [Department of Molecular Function and Pharmacology Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Saitama, Saitama 331-9530 (Japan); Igarashi, Yasuyuki [Laboratory of Biomembrane and Biofunctional Chemistry, Hokkaido University, Sapporo, Hokkaido 060-0812 (Japan); Goitsuka, Ryo [Division of Development and Aging, Research Institute for Biological Sciences, Tokyo University of Science, Noda, Chiba 278-0022 (Japan)

2012-03-23

Highlights: Black-Right-Pointing-Pointer The effect of a newly developed S1P{sub 1}-selective antagonist on angiogenic responses. Black-Right-Pointing-Pointer S1P{sub 1} is a critical component of VEGF-related angiogenic responses. Black-Right-Pointing-Pointer S1P{sub 1}-selective antagonist showed in vitro activity to inhibit angiogenesis. Black-Right-Pointing-Pointer S1P{sub 1}-selective antagonist showed in vivo activity to inhibit angiogenesis. Black-Right-Pointing-Pointer The efficacy of S1P{sub 1}-selective antagonist for anti-cancer therapies. -- Abstract: Sphingosine 1-phosphate receptor type 1 (S1P{sub 1}) was shown to be essential for vascular maturation during embryonic development and it has been demonstrated that substantial crosstalk exists between S1P{sub 1} and other pro-angiogenic growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor. We developed a novel S1P{sub 1}-selective antagonist, TASP0277308, which is structurally unrelated to S1P as well as previously described S1P{sub 1} antagonists. TASP0277308 inhibited S1P- as well as VEGF-induced cellular responses, including migration and proliferation of human umbilical vein endothelial cells. Furthermore, TASP0277308 effectively blocked a VEGF-induced tube formation in vitro and significantly suppressed tumor cell-induced angiogenesis in vivo. These findings revealed that S1P{sub 1} is a critical component of VEGF-related angiogenic responses and also provide evidence for the efficacy of TASP0277308 for anti-cancer therapies.

Y spaces and global smooth solution of fractional Navier-Stokes equations with initial value in the critical oscillation spaces

Science.gov (United States)

Yang, Qixiang; Yang, Haibo

2018-04-01

For fractional Navier-Stokes equations and critical initial spaces X, one used to establish the well-posedness in the solution space which is contained in C (R+ , X). In this paper, for heat flow, we apply parameter Meyer wavelets to introduce Y spaces Y m , β where Y m , β is not contained in C (R+, B˙∞ 1 - 2 β , ∞). Consequently, for 1/2 global well-posedness of fractional Navier-Stokes equations with small initial data in all the critical oscillation spaces. The critical oscillation spaces may be any Besov-Morrey spaces (B˙p,q γ1 ,γ2 (Rn)) n or any Triebel-Lizorkin-Morrey spaces (F˙p,q γ1 ,γ2 (Rn)) n where 1 ≤ p , q ≤ ∞ , 0 ≤γ2 ≤ n/p, γ1 -γ2 = 1 - 2 β. These critical spaces include many known spaces. For example, Besov spaces, Sobolev spaces, Bloch spaces, Q-spaces, Morrey spaces and Triebel-Lizorkin spaces etc.

Description of symmetry of magnetic structures by representations of space groups. [Tables, projecton operator methods

Energy Technology Data Exchange (ETDEWEB)

Sikora, W

1974-10-15

A description of magnetic structures based on the use of representations of space groups is given. Representations of the space groups were established for each compound on the basis of experimental data by the method of projection operators. The compounds contained in the list are collected according to crystal systems, alphabetically within each system. The description of each compound consists of the four parts. The first part contain the chemical symbol of the compound, the second its space group. The next part contains the chemical symbol of the magnetic atom and its positions in Wychoff notation with the number of equivalent positions in the crystal unit cell. The main description of a compound magnetic structure is given in the fourth part. It contains: K vector defined in the reciprocal space, the representation according to which a magnetic structure is transformed and the axial vector function S which describes the magnetic structure.

Mathematical aspects of molecular replacement. III. Properties of space groups preferred by proteins in the Protein Data Bank.

Science.gov (United States)

Chirikjian, G; Sajjadi, S; Toptygin, D; Yan, Y

2015-03-01

The main goal of molecular replacement in macromolecular crystallography is to find the appropriate rigid-body transformations that situate identical copies of model proteins in the crystallographic unit cell. The search for such transformations can be thought of as taking place in the coset space Γ\\G where Γ is the Sohncke group of the macromolecular crystal and G is the continuous group of rigid-body motions in Euclidean space. This paper, the third in a series, is concerned with viewing nonsymmorphic Γ in a new way. These space groups, rather than symmorphic ones, are the most common ones for protein crystals. Moreover, their properties impact the structure of the space Γ\\G. In particular, nonsymmorphic space groups contain both Bieberbach subgroups and symmorphic subgroups. A number of new theorems focusing on these subgroups are proven, and it is shown that these concepts are related to the preferences that proteins have for crystallizing in different space groups, as observed in the Protein Data Bank.

Quasimolecular emission near the Xe(5p 56s 1,3 P 1 - 5p 6 1 S 0) and Kr (4p 55s 1,3 P 1 - 4p 6 1 S 0) resonance lines induced by collisions with He atoms

Science.gov (United States)

Alekseeva, O. S.; Devdariani, A. Z.; Grigorian, G. M.; Lednev, M. G.; Zagrebin, A. L.

2017-02-01

This study is devoted to the theoretical investigation of the quasimolecular emission of Xe*-He and Kr*-He collision pairs near the Xe (5p 56s 1,3 P 1 - 5p 6 1 S 0) and Kr (4p 55s 1,3 P 1 - 4p 6 1 S 0) resonance atomic lines. The potential curves of the quasimolecules Xe(5p 56s) + He and Kr(4p 55s) + He have been obtained with the use of the effective Hamiltonian and pseudopotential methods. Based on these potential curves the processes of quasimolecular emission of Xe*+He and Kr*+He mixtures have been considered and the spectral distributions I(ħΔω) of photons emitted have been obtained in the framework of quasistatic approximation.

Group Analysis in FieldTrip of Time-Frequency Responses: A Pipeline for Reproducibility at Every Step of Processing, Going From Individual Sensor Space Representations to an Across-Group Source Space Representation

Directory of Open Access Journals (Sweden)

Lau M. Andersen

2018-05-01

Full Text Available An important aim of an analysis pipeline for magnetoencephalographic (MEG data is that it allows for the researcher spending maximal effort on making the statistical comparisons that will answer his or her questions. The example question being answered here is whether the so-called beta rebound differs between novel and repeated stimulations. Two analyses are presented: going from individual sensor space representations to, respectively, an across-group sensor space representation and an across-group source space representation. The data analyzed are neural responses to tactile stimulations of the right index finger in a group of 20 healthy participants acquired from an Elekta Neuromag System. The processing steps covered for the first analysis are MaxFiltering the raw data, defining, preprocessing and epoching the data, cleaning the data, finding and removing independent components related to eye blinks, eye movements and heart beats, calculating participants' individual evoked responses by averaging over epoched data and subsequently removing the average response from single epochs, calculating a time-frequency representation and baselining it with non-stimulation trials and finally calculating a grand average, an across-group sensor space representation. The second analysis starts from the grand average sensor space representation and after identification of the beta rebound the neural origin is imaged using beamformer source reconstruction. This analysis covers reading in co-registered magnetic resonance images, segmenting the data, creating a volume conductor, creating a forward model, cutting out MEG data of interest in the time and frequency domains, getting Fourier transforms and estimating source activity with a beamformer model where power is expressed relative to MEG data measured during periods of non-stimulation. Finally, morphing the source estimates onto a common template and performing group-level statistics on the data are

Acute Ankle Sprain in a Mouse Model: Changes in Knee-Joint Space.

Science.gov (United States)

Hubbard-Turner, Tricia; Wikstrom, Erik A; Guderian, Sophie; Turner, Michael J

2017-06-02

  Ankle sprains remain the most common orthopaedic injury. Conducting long-term studies in humans is difficult and costly, so the long-term consequences of an ankle sprain are not entirely known.   To measure knee-joint space after a single surgically induced ankle sprain in mice.   Randomized controlled trial.   University research laboratory.   Thirty male mice (CBA/2J) were randomly placed into 1 of 3 surgical groups: the transected calcaneofibular ligament (CFL) group, the transected anterior talofibular ligament/CFL group, or a sham treatment group. The right ankle was operated on in all mice.   Three days after surgery, all of the mice were individually housed in cages containing a solid-surface running wheel, and daily running-wheel measurements were recorded. Before surgery and every 6 weeks after surgery, a diagnostic ultrasound was used to measure medial and lateral knee-joint space in both hind limbs.   Right medial (P = .003), right lateral (P = .002), left medial (P = .03), and left lateral (P = .002) knee-joint spaces decreased across the life span. The mice in the anterior talofibular ligament/CFL group had decreased right medial (P = .004) joint space compared with the sham and CFL groups starting at 24 weeks of age and continuing throughout the life span. No differences occurred in contralateral knee-joint degeneration among any of the groups.   Based on current data, mice that sustained a surgically induced severe ankle sprain developed greater joint degeneration in the ipsilateral knee. Knee degeneration could result from accommodation to the laxity of the ankle or biomechanical alterations secondary to ankle instability. A single surgically induced ankle sprain could significantly affect knee-joint function.

Space-charge-mediated anomalous ferroelectric switching in P(VDF-TrEE) polymer films

KAUST Repository

Hu, Weijin; Wang, Zhihong; Du, Yuanmin; Zhang, Xixiang; Wu, Tao

2014-01-01

We report on the switching dynamics of P(VDF-TrEE) copolymer devices and the realization of additional substable ferroelectric states via modulation of the coupling between polarizations and space charges. The space-charge-limited current

Axiomatics of uniform space-time models

International Nuclear Information System (INIS)

Levichev, A.V.

1983-01-01

The mathematical statement of space-time axiomatics of the special theory of relativity is given; it postulates that the space-time M is the binding single boundary Hausedorf local-compact four-dimensional topological space with the given order. The theorem is proved: if the invariant order in the four-dimensional group M is given by the semi-group P, which contingency K contains inner points , then M is commutative. The analogous theorem is correct for the group of two and three dimensionalities

Lie groups and symmetric spaces in memory of F. I. Karpelevich

CERN Document Server

Gindikin, S G

2003-01-01

The book contains survey and research articles devoted mainly to geometry and harmonic analysis of symmetric spaces and to corresponding aspects of group representation theory. The volume is dedicated to the memory of Russian mathematician F. I. Karpelevich (1927-2000).

New process of preparation, X-ray characterisation, structure and vibrational studies of a solid solution LiTiOAs 1-xP xO 4 (0⩽ x⩽1)

Science.gov (United States)

Chakir, M.; El Jazouli, A.; Chaminade, J. P.; Bouree, F.; de Waal, D.

2006-01-01

LiTiOAs 1-xP xO 4 (0⩽ x⩽1) compounds have been prepared using solutions of Li, Ti, As and P elements as starting products. Selected compositions have been investigated by powder X-ray or neutrons diffraction analysis, Raman and infrared spectroscopy. The structure of LiTiOAs 1-xP xO 4 ( x=0, 0.5 and 1) samples determined by Rietveld analysis is orthorhombic with Pnma space group. It is formed by a 3D network of TiO 6 octahedra and XO 4 ( X=As 1-xP x) tetrahedra where octahedral cavities are occupied by lithium atoms. TiO 6 octahedra are linked together by corners and form infinite chains along a-axis. Ti atoms are displaced from the centre of octahedral units in alternating short (1.700-1.709 Å) and long (2.301-2.275 Å) Ti-O bonds. Raman and infrared studies confirm the existence of Ti-O-Ti chains. Thermal stability of LiTiOAsO 4 has been reported.

Group Clustering Mechanism for P2P Large Scale Data Sharing Collaboration

Institute of Scientific and Technical Information of China (English)

DENGQianni; LUXinda; CHENLi

2005-01-01

Research shows that P2P scientific collaboration network will exhibit small-world topology, as do a large number of social networks for which the same pattern has been documented. In this paper we propose a topology building protocol to benefit from the small world feature. We find that the idea of Freenet resembles the dynamic pattern of social interactions in scientific data sharing and the small world characteristic of Freenet is propitious to improve the file locating performance in scientificdata sharing. But the LRU (Least recently used) datas-tore cache replacement scheme of Freenet is not suitableto be used in scientific data sharing network. Based onthe group locality of scientific collaboration, we proposean enhanced group clustering cache replacement scheme.Simulation shows that this scheme improves the request hitratio dramatically while keeping the small average hops per successful request comparable to LRU.

Radiation hardening of InP solar cells for space applications

International Nuclear Information System (INIS)

Vilela, M. F.; Freundlich, A.; Monier, C.; Newman, F.; Aguilar, L.

1998-01-01

The aim of this work is to develop a radiation resistant thin InP-based solar cells for space applications on more mechanically resistant, lighter, and cheaper substrates. In this paper, we present the development of a p + /nn + InP-based solar cell structures with very thin emitter and base layers. A thin emitter helps to increase the collection of carriers generated by high energy incident photons from the solar spectrum. The use of a thin n base structure should improve the radiation resistance of this already radiation resistant technology. A remarkable improvement of high energy photons response is shown for InP solar cells with emitters 400 A thick

Group Analysis in MNE-Python of Evoked Responses from a Tactile Stimulation Paradigm: A Pipeline for Reproducibility at Every Step of Processing, Going from Individual Sensor Space Representations to an across-Group Source Space Representation.

Science.gov (United States)

Andersen, Lau M

2018-01-01

An important aim of an analysis pipeline for magnetoencephalographic data is that it allows for the researcher spending maximal effort on making the statistical comparisons that will answer the questions of the researcher, while in turn spending minimal effort on the intricacies and machinery of the pipeline. I here present a set of functions and scripts that allow for setting up a clear, reproducible structure for separating raw and processed data into folders and files such that minimal effort can be spend on: (1) double-checking that the right input goes into the right functions; (2) making sure that output and intermediate steps can be accessed meaningfully; (3) applying operations efficiently across groups of subjects; (4) re-processing data if changes to any intermediate step are desirable. Applying the scripts requires only general knowledge about the Python language. The data analyses are neural responses to tactile stimulations of the right index finger in a group of 20 healthy participants acquired from an Elekta Neuromag System. Two analyses are presented: going from individual sensor space representations to, respectively, an across-group sensor space representation and an across-group source space representation. The processing steps covered for the first analysis are filtering the raw data, finding events of interest in the data, epoching data, finding and removing independent components related to eye blinks and heart beats, calculating participants' individual evoked responses by averaging over epoched data and calculating a grand average sensor space representation over participants. The second analysis starts from the participants' individual evoked responses and covers: estimating noise covariance, creating a forward model, creating an inverse operator, estimating distributed source activity on the cortical surface using a minimum norm procedure, morphing those estimates onto a common cortical template and calculating the patterns of activity

Group Analysis in MNE-Python of Evoked Responses from a Tactile Stimulation Paradigm: A Pipeline for Reproducibility at Every Step of Processing, Going from Individual Sensor Space Representations to an across-Group Source Space Representation

Directory of Open Access Journals (Sweden)

Lau M. Andersen

2018-01-01

Full Text Available An important aim of an analysis pipeline for magnetoencephalographic data is that it allows for the researcher spending maximal effort on making the statistical comparisons that will answer the questions of the researcher, while in turn spending minimal effort on the intricacies and machinery of the pipeline. I here present a set of functions and scripts that allow for setting up a clear, reproducible structure for separating raw and processed data into folders and files such that minimal effort can be spend on: (1 double-checking that the right input goes into the right functions; (2 making sure that output and intermediate steps can be accessed meaningfully; (3 applying operations efficiently across groups of subjects; (4 re-processing data if changes to any intermediate step are desirable. Applying the scripts requires only general knowledge about the Python language. The data analyses are neural responses to tactile stimulations of the right index finger in a group of 20 healthy participants acquired from an Elekta Neuromag System. Two analyses are presented: going from individual sensor space representations to, respectively, an across-group sensor space representation and an across-group source space representation. The processing steps covered for the first analysis are filtering the raw data, finding events of interest in the data, epoching data, finding and removing independent components related to eye blinks and heart beats, calculating participants' individual evoked responses by averaging over epoched data and calculating a grand average sensor space representation over participants. The second analysis starts from the participants' individual evoked responses and covers: estimating noise covariance, creating a forward model, creating an inverse operator, estimating distributed source activity on the cortical surface using a minimum norm procedure, morphing those estimates onto a common cortical template and calculating the patterns

Group vector space method for estimating enthalpy of vaporization of organic compounds at the normal boiling point.

Science.gov (United States)

Wenying, Wei; Jinyu, Han; Wen, Xu

2004-01-01

The specific position of a group in the molecule has been considered, and a group vector space method for estimating enthalpy of vaporization at the normal boiling point of organic compounds has been developed. Expression for enthalpy of vaporization Delta(vap)H(T(b)) has been established and numerical values of relative group parameters obtained. The average percent deviation of estimation of Delta(vap)H(T(b)) is 1.16, which show that the present method demonstrates significant improvement in applicability to predict the enthalpy of vaporization at the normal boiling point, compared the conventional group methods.

Validation of missed space-group symmetry in X-ray powder diffraction structures with dispersion-corrected density functional theory

DEFF Research Database (Denmark)

Hempler, Daniela; Schmidt, Martin U.; Van De Streek, Jacco

2017-01-01

More than 600 molecular crystal structures with correct, incorrect and uncertain space-group symmetry were energy-minimized with dispersion-corrected density functional theory (DFT-D, PBE-D3). For the purpose of determining the correct space-group symmetry the required tolerance on the atomic...... with missed symmetry were investigated by dispersion-corrected density functional theory. In 98.5% of the cases the correct space group is found....

Neutron diffraction studies on Ca1− xBaxZr4P6O24 solid solutions

Indian Academy of Sciences (India)

P6O24 compositions from combined Rietveld refinements of powder X-ray and neutron diffraction data. All the studied compositions crystallize in rhombohedral lattice (space group R-3 No. 148). A continuous solid solution is concluded from ...

Winter School on Operator Spaces, Noncommutative Probability and Quantum Groups

CERN Document Server

2017-01-01

Providing an introduction to current research topics in functional analysis and its applications to quantum physics, this book presents three lectures surveying recent progress and open problems.  A special focus is given to the role of symmetry in non-commutative probability, in the theory of quantum groups, and in quantum physics. The first lecture presents the close connection between distributional symmetries and independence properties. The second introduces many structures (graphs, C*-algebras, discrete groups) whose quantum symmetries are much richer than their classical symmetry groups, and describes the associated quantum symmetry groups. The last lecture shows how functional analytic and geometric ideas can be used to detect and to quantify entanglement in high dimensions.  The book will allow graduate students and young researchers to gain a better understanding of free probability, the theory of compact quantum groups, and applications of the theory of Banach spaces to quantum information. The l...

Comet P/2010 V1 as a Natural Disintegration Laboratory

Science.gov (United States)

Jewitt, David; Weaver, Harold A.; Mutchler, Maximilian J.; Agarwal, Jessica; Meech, Karen Jean; Li, Jing; Kleyna, Jan; Ishiguro, Masateru; Wainscoat, Richard J.; Hui, Man-To

2016-10-01

Discovered in outburst in 2010, Jupiter-family comet P/2010 V1 (Ikeya-Murukami) was found to be split in observations at the end of 2015. We used the Hubble Space Telescope to obtain deep images of P/2010 V1 at high angular resolution in the 2016 January to March period. The resulting data, by far the best yet obtained for any split or disrupting comet, show the astrometric, photometric and morphological evolution of about 30 fragments. We will present the first results for the velocity dispersion, photometric distribution and variability and discuss the measurements in terms of models for the breakup.

A representation independent propagator. Pt. 1. Compact Lie groups

International Nuclear Information System (INIS)

Tome, W.A.

1995-01-01

Conventional path integral expressions for propagators are representation dependent. Rather than having to adapt each propagator to the representation in question, it is shown that for compact Lie groups it is possible to introduce a propagator that is representation independent. For a given set of kinematical variables this propagator is a single function independent of any particular choice of fiducial vector, which monetheless, correctly propagates each element of the coherent state representation associated with these kinematical variables. Although the configuration space is in general curved, nevertheless the lattice phase-space path integral for the representation independent propagator has the form appropriate to flat space. To illustrate the general theory a representation independent propagator is explicitly constructed for the Lie group SU(2). (orig.)

The Hilbert Series of the One Instanton Moduli Space

CERN Document Server

Benvenuti, Sergio; Mekareeya, Noppadol; 10.1007

2010-01-01

The moduli space of k G-instantons on R^4 for a classical gauge group G is known to be given by the Higgs branch of a supersymmetric gauge theory that lives on Dp branes probing D(p + 4) branes in Type II theories. For p = 3, these (3 + 1) dimensional gauge theories have N = 2 supersymmetry and can be represented by quiver diagrams. The F and D term equations coincide with the ADHM construction. The Hilbert series of the moduli spaces of one instanton for classical gauge groups is easy to compute and turns out to take a particularly simple form which is previously unknown. This allows for a G invariant character expansion and hence easily generalisable for exceptional gauge groups, where an ADHM construction is not known. The conjectures for exceptional groups are further checked using some new techniques like sewing relations in Hilbert Series. This is applied to Argyres-Seiberg dualities.

Direct gauging of the Poincare group V. Group scaling, classical gauge theory, and gravitational corrections

International Nuclear Information System (INIS)

Edelen, D.G.B.

1986-01-01

Homogeneous scaling of the group space of the Poincare group, P 10 , is shown to induce scalings of all geometric quantities associated with the local action of P 10 . The field equations for both the translation and the Lorentz rotation compensating fields reduce to O(1) equations if the scaling parameter is set equal to the general relativistic gravitational coupling constant 8πGc -4 . Standard expansions of all field variables in power series in the scaling parameter give the following results. The zeroth-order field equations are exactly the classical field equations for matter fields on Minkowski space subject to local action of an internal symmetry group (classical gauge theory). The expansion process is shown to break P 10 -gauge covariance of the theory, and hence solving the zeroth-order field equations imposes an implicit system of P 10 -gauge conditions. Explicit systems of field equations are obtained for the first- and higher-order approximations. The first-order translation field equations are driven by the momentum-energy tensor of the matter and internal compensating fields in the zeroth order (classical gauge theory), while the first-order Lorentz rotation field equations are driven by the spin currents of the same classical gauge theory. Field equations for the first-order gravitational corrections to the matter fields and the gauge fields for the internal symmetry group are obtained. Direct Poincare gauge theory is thus shown to satisfy the first two of the three-part acid test of any unified field theory. Satisfaction of the third part of the test, at least for finite neighborhoods, seems probable

A Topic Space Oriented User Group Discovering Scheme in Social Network: A Trust Chain Based Interest Measuring Perspective

Directory of Open Access Journals (Sweden)

Wang Dong

2016-01-01

Full Text Available Currently, user group has become an effective platform for information sharing and communicating among users in social network sites. In present work, we propose a single topic user group discovering scheme, which includes three phases: topic impact evaluation, interest degree measurement, and trust chain based discovering, to enable selecting influential topic and discovering users into a topic oriented group. Our main works include (1 an overview of proposed scheme and its related definitions; (2 topic space construction method based on topic relatedness clustering and its impact (influence degree and popularity degree evaluation; (3 a trust chain model to take user relation network topological information into account with a strength classification perspective; (4 an interest degree (user explicit and implicit interest degree evaluation method based on trust chain among users; and (5 a topic space oriented user group discovering method to group core users according to their explicit interest degrees and to predict ordinary users under implicit interest and user trust chain. Finally, experimental results are given to explain effectiveness and feasibility of our scheme.

Synthesis, Structures, and Electrochemistry of Group 6 Aminocarbenes with a P -Chelating 1''-(Diphenylphosphino)ferrocenyl Substituent

Czech Academy of Sciences Publication Activity Database

Meca, L.; Dvořák, D.; Ludvík, Jiří; Císařová, I.; Štěpnička, P.

2004-01-01

Roč. 23, č. 10 (2004), s. 2541-2551 ISSN 0276-7333 R&D Projects: GA ČR GA203/04/0487; GA ČR GA203/99/M037; GA ČR GP203/01/P002 Institutional research plan: CEZ:AV0Z4040901 Keywords : synthesis * electrochemistry of group 6 * chelating Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.196, year: 2004

GeP and (Ge1−xSnx)(P1−yGey) (x≈0.12, y≈0.05): Synthesis, structure, and properties of two-dimensional layered tetrel phosphides

International Nuclear Information System (INIS)

Lee, Kathleen; Synnestvedt, Sarah; Bellard, Maverick; Kovnir, Kirill

2015-01-01

GeP and Sn-doped GeP were synthesized from elements in bismuth and tin flux, respectively. The layered crystal structures of these compounds were characterized by single crystal X-ray diffraction. Both phosphides crystallize in a GaTe structure type in the monoclinic space group C2/m (No. 12) with GeP: a=15.1948(7) Å, b=3.6337(2) Å, c=9.1941(4) Å, β=101.239(2)°; Ge 0.93(3) P 0.95(1) Sn 0.12(3) : a=15.284(9) Å, b=3.622(2) Å, c=9.207(5) Å, β=101.79(1)°. The crystal structure of GeP consists of 2-dimensional GeP layers held together by weak electron lone pair interactions between the phosphorus atoms that confine the layer. Each layer is built of Ge–Ge dumbbells surrounded by a distorted antiprism of phosphorus atoms. Sn-doped GeP has a similar structural motif, but with a significant degree of disorder emphasized by the splitting of all atomic positions. Resistivity measurements together with quantum-chemical calculations reveal semiconducting behavior for the investigated phosphides. - Graphical abstract: Layered phosphides GeP and Sn-doped GeP were synthesized from elements in bismuth and tin flux, respectively. The crystal structure of GeP consists of 2-dimensional GeP layers held together by weak electron lone pair interactions between the phosphorus atoms that confine the layer. Sn-doped GeP has a similar structural motif with a significant degree of disorder emphasized by the splitting of all atomic positions. Resistivity measurements together with quantum-chemical calculations reveal semiconducting behavior for the investigated phosphides. - Highlights: • GeP crystallizes in a layered crystal structure. • Doping of Sn into GeP causes large structural distortions. • GeP is narrow bandgap semiconductor. • Sn-doped GeP exhibits an order of magnitude higher resistivity due to disorder

Analytic factorization of Lie group representations

DEFF Research Database (Denmark)

Gimperlein, Heiko; Krötz, Bernhard; Lienau, Christoph

2012-01-01

For every moderate growth representation (p,E)(p,E) of a real Lie group G on a Fréchet space, we prove a factorization theorem of Dixmier–Malliavin type for the space of analytic vectors E¿E¿. There exists a natural algebra of superexponentially decreasing analytic functions A(G)A(G), such that E......¿=¿(A(G))E¿E¿=¿(A(G))E¿. As a corollary we obtain that E¿E¿ coincides with the space of analytic vectors for the Laplace–Beltrami operator on G....

Crystallization and initial X-ray diffraction studies of the flavoenzyme NAD(P)H:(acceptor) oxidoreductase (FerB) from the soil bacterium Paracoccus denitrificans

International Nuclear Information System (INIS)

Klumpler, Tomáš; Sedláček, Vojtěch; Marek, Jaromír; Wimmerová, Michaela; Kučera, Igor

2010-01-01

The flavin-dependent enzyme FerB from P. denitrificans has been purified and both native and SeMet-substituted FerB have been crystallized. The two variants crystallized in two different crystallographic forms belonging to the monoclinic space group P2 1 and the orthorhombic space group P2 1 2 1 2, respectively. X-ray diffraction data were collected to 1.75 Å resolution for both forms. The flavin-dependent enzyme FerB from Paracoccus denitrificans reduces a broad range of compounds, including ferric complexes, chromate and most notably quinones, at the expense of the reduced nicotinamide adenine dinucleotide cofactors NADH or NADPH. Recombinant unmodified and SeMet-substituted FerB were crystallized under similar conditions by the hanging-drop vapour-diffusion method with microseeding using PEG 4000 as the precipitant. FerB crystallized in several different crystal forms, some of which diffracted to approximately 1.8 Å resolution. The crystals of native FerB belonged to space group P2 1 , with unit-cell parameters a = 61.6, b = 110.1, c = 65.2 Å, β = 118.2° and four protein molecules in the asymmetric unit, whilst the SeMet-substituted form crystallized in space group P2 1 2 1 2, with unit-cell parameters a = 61.2, b = 89.2, c = 71.5 Å and two protein molecules in the asymmetric unit. Structure determination by the three-wavelength MAD/MRSAD method is now in progress

μ-Sulfido-bis{[1,1′-bis(diphenylphosphanylferrocene-κ2P,P′]gold} methanol monosolvate

Directory of Open Access Journals (Sweden)

Takuma Itai

2016-01-01

Full Text Available The gold complex in title compound, [Au2Fe(C17H14P2S]·CH3OH, (I·CH3OH, is closely similar to the previously reported (I·2CHCl3, reported in the literature [Canales et al. (1996. J. Am. Chem. Soc. 118, 4839–4845]. Both crystallize in the monoclinic crystal systems but the space groups differ, P21/n for (I·CH3OH compared to P2/n for (I·2CHCl3. The two structures can be considered as polymorphs due to solvation differences. In (I·CH3OH, all atoms of the methanol solvent molecule are disordered over two sets of sites with an occupancy ratio of 0.822 (12:0.178 (12. The crystal structure features O—H...S, C—H...S hydrogen bonds and C—H...π interactions that stack the complex molecules along the a-axis direction.

A P212121 polymorph of (+-clusianone

Directory of Open Access Journals (Sweden)

Teng-Jin Khoo

2013-12-01

Full Text Available The title compound, C33H42O4 [systematic name: (1S,5S,7R-3-benzoyl-4-hydroxy-8,8-dimethyl-1,5,7-tris(3-methylbut-2-enylbicyclo[3.3.1]nona-3-ene-2,9-dione], has a central bicyclo[3.3.1]nonane-2,4,9-trione surrounded by tetraprenylated and benzoyl groups. The compound was recrystallized several times in methanol using both a slow evaporation method and with a crystal-seeding technique. This subsequently produced diffraction-quality crystals which crystallize in the orthorhombic space group P212121, in contrast to a previous report of a structure determination in the Pna21 space group [McCandlish et al. (1976. Acta Cryst. B32, 1793–1801]. The title compound has a melting point of 365–366 K, and a specific rotation [α]20 value of +51.94°. A strong intramolecular O—H...O hydrogen bond is noted. In the crystal, molecules are assembled in the ab plane by weak C—H...O interactions.

The short range effective interaction and the spectra of calcium isotopes in (f-p) space

International Nuclear Information System (INIS)

Qing-ying, Z.; Shen-wu, L.; Jian-xin, W.

1986-01-01

In this work, the authors use a new type of extremely short range interaction, the double delta interaction (DDI) to calculate the low-lying spectra of calcium isotopes /sup 41/Ca through /sup 48/Ca. The configuration space (f-p) includes configurations ( f/sub 7/2//sup n/ ) and ( f/sub 7/2//sup n-1/2p/sub 3/2/). The calculated energies are compared with experimental data for 75 levels. For comparison, they also use usual modified surface delta interaction (MSDI) to calculate the same spectra aforementioned. It is clear that the results calculated with DDI are better than with MSDI. Therefore, in the short-range effective interaction the addition of body delta force to the modified surface delta force may improve the agreement with experiment. The authors believe that the conclusion will not be changed if one enlarges the shell model space

Numerical simulation of amplification of space charge waves in n-InP films

International Nuclear Information System (INIS)

Garcia-Barrientos, Abel; Palankovski, Vassil

2011-01-01

The non-linear interaction of space charge waves including the amplification in microwave and millimeter wave range in n-InP films, possessing the negative differential conductance phenomenon, is investigated theoretically. Both the amplified signal and the generation of harmonics of the input signal are demonstrated, which are due to non-linear effect of the negative differential resistance. It is possible to observe an amplification of the space charge waves in n-InP films of submicron thicknesses at essentially higher frequencies f <70 GHz, when compared with n-GaAs films f < 44 GHz. The increment observed in the gain is due to the larger dynamic range in n-InP than in n-GaAs films.

Group quantization on configuration space: Gauge symmetries and linear fields

International Nuclear Information System (INIS)

Navarro, M.; Aldaya, V.; Calixto, M.

1997-01-01

A new, configuration-space picture of a formalism of group quantization, the GAQ formalism, is presented in the context of a previous algebraic generalization. This presentation serves to make a comprehensive discussion in which other extensions of the formalism, principally to incorporate gauge symmetries, are developed as well. Both images are combined in order to analyze, in a systematic manner and with complete generality, the case of linear fields (Abelian current groups). To illustrate these developments we particularize them for several fields and, in particular, we carry out the quantization of the Abelian Chern endash Simons models over an arbitrary closed surface in detail. copyright 1997 American Institute of Physics

Crystallization and preliminary X-ray diffraction analysis of phospholipid-bound Sfh1p, a member of the Saccharomyces cerevisiae Sec14p-like phosphatidylinositol transfer protein family

International Nuclear Information System (INIS)

Schaaf, Gabriel; Betts, Laurie; Garrett, Teresa A.; Raetz, Christian R. H.; Bankaitis, Vytas A.

2006-01-01

Yeast Sfh1p, a close homolog of the Sec14p phosphatidylinositol transfer protein, was crystallized in the absence of detergent. X-ray data have been collected to 2.5 Å. Sec14p is the major phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein in the budding yeast Saccharomyces cerevisiae and is the founding member of a large eukaryotic protein superfamily. This protein catalyzes the exchange of either PtdIns or PtdCho between membrane bilayers in vitro and this exchange reaction requires no external input of energy or of other protein cofactors. Despite the previous elucidation of the crystal structure of a detergent-bound form of Sec14p, the conformational changes that accompany the phospholipid-exchange reaction remain undefined. Moreover, a structural appreciation of how Sec14p or its homologs bind their various phospholipid substrates remains elusive. Here, the purification and crystallization of yeast Sfh1p, the protein most closely related to Sec14p, are reported. A combination of electrospray ionization mass-spectrometry and collision-induced decomposition mass-spectrometry methods indicate that recombinant Sfh1p loads predominantly with phosphatidylethanolamine. Unlike phospholipid-bound forms of Sec14p, this form of Sfh1p crystallizes readily in the absence of detergent. Sfh1p crystals diffract to 2.5 Å and belong to the orthorhombic primitive space group P2 1 2 1 2 1 , with unit-cell parameters a = 49.40, b = 71.55, c = 98.21 Å, α = β = γ = 90°. One Sfh1p molecule is present in the asymmetric unit (V M = 2.5 Å 3 Da −1 ; V s = 50%). Crystallization of a phospholipid-bound Sec14p-like protein is a critical first step in obtaining the first high-resolution picture of how proteins of the Sec14p superfamily bind their phospholipid ligands. This information will significantly extend our current understanding of how Sec14p-like proteins catalyze phospholipid exchange

Bootstrap percolation: a renormalisation group approach

International Nuclear Information System (INIS)

Branco, N.S.; Santos, Raimundo R. dos; Queiroz, S.L.A. de.

1984-02-01

In bootstrap percolation, sites are occupied at random with probability p, but each site is considered active only if at least m of its neighbours are also active. Within an approximate position-space renormalization group framework on a square lattice we obtain the behaviour of the critical concentration p (sub)c and of the critical exponents ν and β for m = 0 (ordinary percolation), 1,2 and 3. We find that the bootstrap percolation problem can be cast into different universality classes, characterized by the values of m. (author) [pt

Abstract structure of partial function $*$-algebras over semi-direct product of locally compact groups

Directory of Open Access Journals (Sweden)

Arash Ghaani Farashahi

2015-12-01

Full Text Available This article presents a unified approach to the abstract notions of partial convolution and involution in $L^p$-function spaces over semi-direct product of locally compact groups. Let $H$ and $K$ be locally compact groups and $tau:Hto Aut(K$ be a continuous homomorphism.  Let $G_tau=Hltimes_tau K$ be the semi-direct product of $H$ and $K$ with respect to $tau$. We define left and right $tau$-convolution on $L^1(G_tau$ and we show that, with respect to each of them, the function space $L^1(G_tau$ is a Banach algebra. We define $tau$-convolution as a linear combination of the left and right $tau$-convolution and we show that the $tau$-convolution is commutative if and only if $K$ is abelian. We prove that there is a $tau$-involution on $L^1(G_tau$ such that with respect to the $tau$-involution and $tau$-convolution, $L^1(G_tau$ is a non-associative Banach $*$-algebra. It is also shown that when $K$ is abelian, the $tau$-involution and $tau$-convolution make $L^1(G_tau$ into a Jordan Banach $*$-algebra. Finally, we also present the generalized notation of $tau$-convolution for other $L^p$-spaces with $p>1$.

Realizing spaces as path-component spaces

OpenAIRE

Banakh, Taras; Brazas, Jeremy

2018-01-01

The path component space of a topological space $X$ is the quotient space $\\pi_0(X)$ whose points are the path components of $X$. We show that every Tychonoff space $X$ is the path-component space of a Tychonoff space $Y$ of weight $w(Y)=w(X)$ such that the natural quotient map $Y\\to \\pi_0(Y)=X$ is a perfect map. Hence, many topological properties of $X$ transfer to $Y$. We apply this result to construct a compact space $X\\subset \\mathbb{R}^3$ for which the fundamental group $\\pi_1(X,x_0)$ is...

Thiocarbonyl complexes of rhenium. Pt. 1

International Nuclear Information System (INIS)

Abram, U.

1993-01-01

Novel rhenium complexes with terminal thiocarbonyl groups have been synthesized from ReCl 3 (Me 2 PhP) 3 and sodium diethyldithiocarbamate. mer-(Diethyldithiocarbamato)tris-(dimethylphenylphosphine)(thiocarbonyl)rhenium( I), mer-[Re(CS)(Me 2 PhP) 3 (Et 2 dtc)], and tris(diethyldithiocarbamato)(thiocarbonyl)rhenium(III), [Re(CS)(Et 2 dtc) 3 ] have been studied by infrared and NMR spectroscopy, mass spectrometry and X-ray diffraction. mer-[Re(CS)(Me 2 PhP) 3 (Et 2 dtc)] crystallizes orthorhombic in the space group P na 2 1 with a=1516.1(2), b=2189.8(2) and c=1035.6(1) pm. Structure solution and refinement converged at R=0.042. The coordination geometry is a distorted octahedron. The Re-C bond length is found to be 184(2) pm. [Re(CS)(Et 2 dtc) 3 ] crystallizes monoclinic in the space group P2 1 /c with a=962.2(6), b=1744.0(2), c=1537.4(6) pm and β=96.21(1) . The final R value is 0.028. In the monomeric complex the rhenium atom is seven-coordinate with an approximate pentagonal-bipyramidal coordination sphere and a rhenium-carbon distance of 181(1) pm. (orig.)

Crystallization and preliminary X-ray diffraction analysis of two extracytoplasmic solute receptors of the DctP family from Bordetella pertussis

International Nuclear Information System (INIS)

Rucktooa, Prakash; Huvent, Isabelle; Antoine, Rudy; Lecher, Sophie; Jacob-Dubuisson, Françoise; Villeret, Vincent; Bompard, Coralie

2006-01-01

Sample preparation, crystallization and preliminary X-ray analysis are reported for two B. pertussis extracytoplasmic solute receptors. DctP6 and DctP7 are two Bordetella pertussis proteins which belong to the extracytoplasmic solute receptors (ESR) superfamily. ESRs are involved in the transport of substrates from the periplasm to the cytosol of Gram-negative bacteria. DctP6 and DctP7 have been crystallized and diffraction data were collected using a synchrotron-radiation source. DctP6 crystallized in space group P4 1 2 1 2, with unit-cell parameters a = 108.39, b = 108.39, c = 63.09 Å, while selenomethionyl-derivatized DctP7 crystallized in space group P2 1 2 1 2 1 , with unit-cell parameters a = 64.87, b = 149.83, c = 170.65 Å. The three-dimensional structure of DctP7 will be determined by single-wavelength anomalous diffraction, while the DctP6 structure will be solved by molecular-replacement methods

Co-H-spaces and almost localization

OpenAIRE

Costoya, Cristina; Iwase, Norio

2012-01-01

Apart from simply-connected spaces, a non simply-connected co-H-space is a typical example of a space X with a co-action of $B\\pi_1(X)$ along $r^X : X \\rightarrow B\\pi_{1}(X)$ the classifying map of the universal covering. If such a space X is actually a co-H-space, then the fibrewise p-localization of $r^X$ (or the `almost' p-localization of X) is a fibrewise co-H-space (or an `almost' co-H-space, resp.) for every prime p. In this paper, we show that the converse statement is true, i.e., for...

Efimov spaces and the separable quotient problem for spaces C-P(K)

Czech Academy of Sciences Publication Activity Database

Kąkol, Jerzy; Śliwa, W.

2018-01-01

Roč. 457, č. 1 (2018), s. 104-113 ISSN 0022-247X R&D Projects: GA ČR GF16-34860L Institutional support: RVO:67985840 Keywords : spaces of continuous functions * pointwise topology * separable quotient problem Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 1.064, year: 2016 http://www. science direct.com/ science /article/pii/S0022247X17307588?via%3Dihub

Efimov spaces and the separable quotient problem for spaces C-P(K)

Czech Academy of Sciences Publication Activity Database

Kąkol, Jerzy; Śliwa, W.

2018-01-01

Roč. 457, č. 1 (2018), s. 104-113 ISSN 0022-247X R&D Projects: GA ČR GF16-34860L Institutional support: RVO:67985840 Keywords : spaces of continuous functions * pointwise topology * separable quotient problem Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 1.064, year: 2016 http://www.sciencedirect.com/science/article/pii/S0022247X17307588?via%3Dihub

Superspace group descriptions of the symmetries of incommensurate urea inclusion compounds

NARCIS (Netherlands)

vanSmaalen, S; Harris, KDM

1996-01-01

Urea inclusion compounds are a class of incommensurate composite crystals. The urea molecules form a three-dimensionally connected network, with approximate space group symmetry P6(1)22. This network contains tunnels (channels), which accommodate guest molecules. The periodicities of the urea

Irreducible quantum group modules with finite dimensional weight spaces

DEFF Research Database (Denmark)

Pedersen, Dennis Hasselstrøm

a finitely generated U q -module which has finite dimensional weight spaces and is a sum of those. Our approach follows the procedures used by S. Fernando and O. Mathieu to solve the corresponding problem for semisimple complex Lie algebra modules. To achieve this we have to overcome a number of obstacles...... not present in the classical case. In the process we also construct twisting functors rigerously for quantum group modules, study twisted Verma modules and show that these admit a Jantzen filtration with corresponding Jantzen sum formula....

[Nah-plasmids of IncP-9 group from natural strains of Pseudomonas].

Science.gov (United States)

Levchuk, A A; Bulyga, I M; Izmalkova, T Iu; Sevast'ianovich, Ia R; Kosheleva, I A; Thomas, C M; Titok, M A

2006-01-01

Use of polymerase chain reaction helped to establish that the most frequent among naphthalene utilizing bacteria, isolated on the territory of Belarus, are Nah-plasmids of IncP-9 incompatibility group and those with indefinite systematic belonging. With the help of classical test of incompatibility, restriction and sequence analyses three new subgroups within the IncP-9 group were discovered (zeta, eta and IncP-9-like replicons). Conducting of restriction analysis for amplification products of nahG and nahAc genes allowed us to reveal, in addition to known sequences of stated determinants, two new types of nahG gene. Restriction analysis performed on amplification products of 16S RNA genes (ARDRA method) showed that native hosts of Nah-plasmids of IncP-9 group are not only fluorescent bacteria from genus Pseudomonas (P. fluorescens, P. putida, P. aeruginosa, P. species), but also non-fluorescent bacteria with indefinite specific belonging.

Geometry, rigidity, and group actions

CERN Document Server

Farb, Benson; Zimmer, Robert J

2011-01-01

The study of group actions is more than a hundred years old but remains to this day a vibrant and widely studied topic in a variety of mathematic fields. A central development in the last fifty years is the phenomenon of rigidity, whereby one can classify actions of certain groups, such as lattices in semi-simple Lie groups. This provides a way to classify all possible symmetries of important spaces and all spaces admitting given symmetries. Paradigmatic results can be found in the seminal work of George Mostow, Gergory Margulis, and Robert J. Zimmer, among others.The p

CfDS attends the first meeting of the All-Party Parliamentary Astronomy and Space Environment Group

Science.gov (United States)

Mizon, B.

1999-06-01

This group first met on March 11th, 1999, as 'a forum for discussion to further parliamentary interest in astronomy and the space environment affecting terrestrial life and its climate; and to increase awareness of the social, political and philosophical implications of present and future space technologies connected with exploring and understanding the cosmos'. CfDS coordinator Bob Mizon attended the first meeting of the group.

Study of TiO2(1 1 0)-p(1x1), p(1x2) and p(1x3) surface structures by impact collision ion scattering spectroscopy (ICISS)

International Nuclear Information System (INIS)

Asari, E.; Souda, R.

2000-01-01

The surface structure of TiO 2 (1 1 0)-p(1x1), p(1x2) and p(1x3) were studied using impact collision ion scattering spectroscopy (ICISS). We found that (i) the height of bridging oxygen for the p(1x1) is comparative to that of bulk structure, (ii) the p(1x2) surface has the added Ti 2 O 3 unit rows proposed by Onishi et al. and also the oxygen atoms rows between Ti 2 O 3 unit rows and (iii) the p(1x3) surface is constructed with the same added Ti 2 O 3 unit rows as that in the p(1x2) surface, but the bridging oxygen rows exist between the Ti 2 O 3 unit rows

The dual algebra of the Poincare group on Fock space

International Nuclear Information System (INIS)

Klink, W.H.; Iowa Univ., Iowa City, IA

1989-01-01

The Lie algebra of operators commuting with the Poincare group on the Fock space appropriate for a massive spinless particle is constructed in terms of raising and lowering operators indexed by a Lorentz invariant function. From the assumption that the phase operator is an element of this Lie algebra, it is shown that the scattering operator can be written as a unitary representation operator of the group associated with the Lie algebra. A simple choice of the phase operator shows that the Lorentz invariant function can be interpreted as a basic scattering amplitude, in the sense that all multiparticle scattering amplitudes can be written in terms of this basic scattering amplitude. (orig.)

Crystallization and preliminary X-ray crystallographic analysis of Thermotoga maritima CheA P3-P4-P5 domains in complex with CheW

International Nuclear Information System (INIS)

Park, SangYoun; Kim, Keon Young; Kim, Sunmin; Crane, Brian R.

2012-01-01

T. maritima CheA P3-P4-P5 domains were crystallized in complex with CheW. Low-resolution diffraction data were collected to ∼8 Å using synchrotron X-ray radiation. The CheA–CheW complex plays a key role in bacterial chemotaxis signal transduction by initiating phosphotransfer to response regulators via coupling to the chemoreceptors. CheA (P3-P4-P5 domains) and CheW from Thermotoga maritima were overexpressed in Escherichia coli and crystallized as a complex at 298 K using ammonium dihydrogen phosphate as a precipitant. X-ray diffraction data were collected to ∼8 Å resolution at 100 K using synchrotron radiation. The crystal belonged to space group I222 or I2 1 2 1 2 1 , with unit-cell parameters a = 184.2, b = 286.4, c = 327.7 Å. The asymmetric unit may contain six to ten CheA–CheW molecules

Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium.

Science.gov (United States)

Harijith, Anantha; Pendyala, Srikanth; Ebenezer, David L; Ha, Alison W; Fu, Panfeng; Wang, Yue-Ting; Ma, Ke; Toth, Peter T; Berdyshev, Evgeny V; Kanteti, Prasad; Natarajan, Viswanathan

2016-08-01

Hyperoxia-induced lung injury adversely affects ICU patients and neonates on ventilator assisted breathing. The underlying culprit appears to be reactive oxygen species (ROS)-induced lung damage. The major contributor of hyperoxia-induced ROS is activation of the multiprotein enzyme complex NADPH oxidase. Sphingosine-1-phosphate (S1P) signaling is known to be involved in hyperoxia-mediated ROS generation; however, the mechanism(s) of S1P-induced NADPH oxidase activation is unclear. Here, we investigated various steps in the S1P signaling pathway mediating ROS production in response to hyperoxia in lung endothelium. Of the two closely related sphingosine kinases (SphKs)1 and 2, which synthesize S1P from sphingosine, only Sphk1(-/-) mice conferred protection against hyperoxia-induced lung injury. S1P is metabolized predominantly by S1P lyase and partial deletion of Sgpl1 (Sgpl1(+/-)) in mice accentuated lung injury. Hyperoxia stimulated S1P accumulation in human lung microvascular endothelial cells (HLMVECs), and downregulation of S1P transporter spinster homolog 2 (Spns2) or S1P receptors S1P1&2, but not S1P3, using specific siRNA attenuated hyperoxia-induced p47(phox) translocation to cell periphery and ROS generation in HLMVECs. These results suggest a role for Spns2 and S1P1&2 in hyperoxia-mediated ROS generation. In addition, p47(phox) (phox:phagocyte oxidase) activation and ROS generation was also reduced by PF543, a specific SphK1 inhibitor in HLMVECs. Our data indicate a novel role for Spns2 and S1P1&2 in the activation of p47(phox) and production of ROS involved in hyperoxia-mediated lung injury in neonatal and adult mice. Copyright © 2016 the American Physiological Society.

Familial partial duplication (1)(p21p31)

Energy Technology Data Exchange (ETDEWEB)

Hoechstetter, L.; Soukup, S.; Schorry, E.K. [Children`s Hospital Research Foundation, Cincinnati, OH (United States)

1995-11-20

A partial duplication (1)(p21p31), resulting from a maternal direct insertion (13,1) (q22p21p31), was found in a 30-year-old woman with mental retardation, cleft palate, and multiple minor anomalies. Two other affected and deceased relatives were presumed to have the same chromosome imbalance. Duplication 1p cases are reviewed. 8 refs., 5 figs., 1 tab.

Quantification in mass units of group 1 grass allergens by a monoclonal antibody-based sandwich ELISA.

Science.gov (United States)

Arilla, M C; Ibarrola, I; Eraso, E; Aguirre, M; Martínez, A; Asturias, J A

2001-08-01

Grass pollen extracts currently used for allergy diagnosis and immunotherapy are a complex mixture of proteins of which only a few have allergenic activity. Lol p 1 is one of the most important allergens in grass pollen extracts. To develop a two-site enzyme-linked immunosorbent assay for the quantification of Lol p 1 and other group 1 allergens from grass species, and to assess its suitability for quantifying this group of allergens. Balb/c mice immunized with recombinant Lol p 1 were used for the production of monoclonal antibodies. Screening of hybridomas was performed by direct ELISA, and selected monoclonal antibodies were immobilized on ELISA plates and incubated with samples containing group 1 allergens. Bound allergens were detected by a combination of biotinylated Lol p 1-specific monoclonal antibody and peroxidase-streptavidin conjugate. The assay is based on three Lol p 1-specific monoclonal antibodies with different epitope specificities. The optimized ELISA measured Lol p 1 concentrations ranging from 125 to 1000 ng/mL and could quantify group 1 allergen from grass species belonging to the Pooidea subfamily. The assay does not depend on anti-sera production or availability of human sera and thus reactives can be produced in unlimited amounts. This sensitive and specific Lol p 1 assay will be helpful both for quantifying the group 1 allergen content of Pooideae pollen extracts intended for clinical use and for studying cross-reactivities among pollen extracts.

The color tuning of PS-b-P2VP lamellar films with changing the alkyl chain length of 1-iodoalkanes.

Science.gov (United States)

Shin, Sung-Eui; Kim, Su-Young; Shin, Dong-Myung

2011-05-01

Photonic crystals with tunability in the visible or near-infrared region have drawn increasing attention for controlling and processing light for the active components of future display. We prepared polystyrene-b-poly(2-vinyl pyridine) (PS-b-P2VP) lamellar films which is hydrophobic block-hydrophilic polyelectrolyte block polymer of 57 kg/mol-b-57 kg/mol. The lamellar stacks, which is alternating layer of hydrophilic and hydrophobic moiety of PS-b-P2VP, are obtained by exposing the spin coated film under chloroform vapor. The band gaps of the lamellar films interestingly varied after immersion into the quaternizing solvents containing 5 wt% of iodomethane, iodoethane, 1-iodobutane, 1-iodopentane, 1-iodohexane and 1-iodooctane solubilized in n-hexane. The iodoalkanes reacted with pyridine groups in PS-b-P2VP and generated the alkyl pyridinium salts readily. The degree of quaternization, alkyl chain length of iodoalkane and the salt water concentration affects the spacing of layer structure of PS-b-P2VP. The iodomethane and iodohexane produced similar band gaps and salt concentration dependence. These results are very much dependent on the hydrophobic-hydrophilic characters of PS-b-P2VP lamellar surface.

Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1

Science.gov (United States)

Moll, Kirsten; Palmkvist, Mia; Ch'ng, Junhong; Kiwuwa, Mpungu Steven; Wahlgren, Mats

2015-01-01

The ABO blood group antigens are expressed on erythrocytes but also on endothelial cells, platelets and serum proteins. Notably, the ABO blood group of a malaria patient determines the development of the disease given that blood group O reduces the probability to succumb in severe malaria, compared to individuals of groups A, B or AB. P. falciparum rosetting and sequestration are mediated by PfEMP1, RIFIN and STEVOR, expressed at the surface of the parasitized red blood cell (pRBC). Antibodies to these antigens consequently modify the course of a malaria infection by preventing sequestration and promoting phagocytosis of pRBC. Here we have studied rosetting P. falciparum and present evidence of an immune evasion mechanism not previously recognized. We find the accessibility of antibodies to PfEMP1 at the surface of the pRBC to be reduced when P. falciparum forms rosettes in blood group A RBC, as compared to group O RBC. The pRBC surrounds itself with tightly bound normal RBC that makes PfEMP1 inaccessible to antibodies and clearance by the immune system. Accordingly, pRBC of in vitro cloned P. falciparum devoid of ABO blood group dependent rosetting were equally well detected by anti-PfEMP1 antibodies, independent of the blood group utilized for their propagation. The pathogenic mechanisms underlying the severe forms of malaria may in patients of blood group A depend on the ability of the parasite to mask PfEMP1 from antibody recognition, in so doing evading immune clearance. PMID:26714011

Invariant subspaces in some function spaces on symmetric spaces. II

International Nuclear Information System (INIS)

Platonov, S S

1998-01-01

Let G be a semisimple connected Lie group with finite centre, K a maximal compact subgroup of G, and M=G/K a Riemannian symmetric space of non-compact type. We study the problem of describing the structure of closed linear subspaces in various function spaces on M that are invariant under the quasiregular representation of the group G. We consider the case when M is a symplectic symmetric space of rank 1

Quantum groups, roots of unity and particles on quantized Anti-de Sitter space

International Nuclear Information System (INIS)

Steinacker, H.

1997-01-01

Quantum groups in general and the quantum Anti-de Sitter group U q (so(2,3)) in particular are studied from the point of view of quantum field theory. The author shows that if q is a suitable root of unity, there exist finite-dimensional, unitary representations corresponding to essentially all the classical one-particle representations with (half) integer spin, with the same structure at low energies as in the classical case. In the massless case for spin ≥ 1, open-quotes naiveclose quotes representations are unitarizable only after factoring out a subspace of open-quotes pure gaugesclose quotes, as classically. Unitary many-particle representations are defined, with the correct classical limit. Furthermore, the author identifies a remarkable element Q in the center of U q (g), which plays the role of a BRST operator in the case of U q (so(2,3)) at roots of unity, for any spin ≥ 1. The associated ghosts are an intrinsic part of the indecomposable representations. The author shows how to define an involution on algebras of creation and anihilation operators at roots of unity, in an example corresponding to non-identical particles. It is shown how nonabelian gauge fields appear naturally in this framework, without having to define connections on fiber bundles. Integration on Quantum Euclidean space and sphere and on Anti-de Sitter space is studied as well. The author gives a conjecture how Q can be used in general to analyze the structure of indecomposable representations, and to define a new, completely reducible associative (tensor) product of representations at roots of unity, which generalizes the standard open-quotes truncatedclose quotes tensor product as well as many-particle representations

Quantum groups, roots of unity and particles on quantized Anti-de Sitter space

Energy Technology Data Exchange (ETDEWEB)

Steinacker, Harold [Univ. of California, Berkeley, CA (United States). Dept. of Physics

1997-05-23

Quantum groups in general and the quantum Anti-de Sitter group U_q(so(2,3)) in particular are studied from the point of view of quantum field theory. The author shows that if q is a suitable root of unity, there exist finite-dimensional, unitary representations corresponding to essentially all the classical one-particle representations with (half) integer spin, with the same structure at low energies as in the classical case. In the massless case for spin ≥ 1, "naive" representations are unitarizable only after factoring out a subspace of "pure gauges", as classically. Unitary many-particle representations are defined, with the correct classical limit. Furthermore, the author identifies a remarkable element Q in the center of U_q(g), which plays the role of a BRST operator in the case of U_q(so(2,3)) at roots of unity, for any spin ≥ 1. The associated ghosts are an intrinsic part of the indecomposable representations. The author shows how to define an involution on algebras of creation and anihilation operators at roots of unity, in an example corresponding to non-identical particles. It is shown how nonabelian gauge fields appear naturally in this framework, without having to define connections on fiber bundles. Integration on Quantum Euclidean space and sphere and on Anti-de Sitter space is studied as well. The author gives a conjecture how Q can be used in general to analyze the structure of indecomposable representations, and to define a new, completely reducible associative (tensor) product of representations at roots of unity, which generalizes the standard "truncated" tensor product as well as many-particle representations.

Space Nuclear Facility test capability at the Baikal-1 and IGR sites Semipalatinsk-21, Kazakhstan

Science.gov (United States)

Hill, T. J.; Stanley, M. L.; Martinell, J. S.

1993-01-01

The International Space Technology Assessment Program was established 1/19/92 to take advantage of the availability of Russian space technology and hardware. DOE had two delegations visit CIS and assess its space nuclear power and propulsion technologies. The visit coincided with the Conference on Nuclear Power Engineering in Space Nuclear Rocket Engines at Semipalatinsk-21 (Kurchatov, Kazakhstan) on Sept. 22-25, 1992. Reactor facilities assessed in Semipalatinski-21 included the IVG-1 reactor (a nuclear furnace, which has been modified and now called IVG-1M), the RA reactor, and the Impulse Graphite Reactor (IGR), the CIS version of TREAT. Although the reactor facilities are being maintained satisfactorily, the support infrastructure appears to be degrading. The group assessment is based on two half-day tours of the Baikals-1 test facility and a brief (2 hr) tour of IGR; because of limited time and the large size of the tour group, it was impossible to obtain answers to all prepared questions. Potential benefit is that CIS fuels and facilities may permit USA to conduct a lower priced space nuclear propulsion program while achieving higher performance capability faster, and immediate access to test facilities that cannot be available in this country for 5 years. Information needs to be obtained about available data acquisition capability, accuracy, frequency response, and number of channels. Potential areas of interest with broad application in the U.S. nuclear industry are listed.

Posttranscriptional regulation of the karyogamy gene by Kem1p/Xrn1p exoribonuclease and Rok1p RNA helicase of Saccharomyces cerevisiae

International Nuclear Information System (INIS)

Kim, Jaehee; Jeon, Soonmee; Yang, Yun-Seok; Kim, Jinmi

2004-01-01

The major biochemical activities ascribed to Kem1p/Xrn1p of Saccharomyces cerevisiae are 5'-3' exoribonuclease functioning in RNA turnover and a microtubule-binding protein. Mutational analysis has shown that Kem1p/Xrn1p participates in microtubule-related functions such as nuclear fusion (karyogamy) during mating, chromosome transmission, and spindle pole body duplication. Here, evidence is presented that Kem1p plays a specific role in nuclear fusion by affecting, at the posttranscriptional level, the pheromone induction of the karyogamy-specific transcription factor Kar4p and the expression of Rok1p, a putative RNA helicase. We found that Rok1p itself also affects the pheromone induction of Kar4p and thereby participates in nuclear fusion. Analysis of the active-site mutations, xrn1-D206A or D208A, shows that nuclear fusion as well as the Rok1p synthesis do not require the exoribonuclease activity of Kem1p. Our data provide an important insight into the gene-specific regulatory function mediated by the general RNA-modulating enzymes

Hypersurfaces in Pⁿ with 1-parameter symmetry groups II

DEFF Research Database (Denmark)

Plessis, Andrew du; Wall, C.T.C.

2010-01-01

We assume V a hypersurface of degree d in with isolated singularities and not a cone, admitting a group G of linear symmetries. In earlier work we treated the case when G is semi-simple; here we analyse the unipotent case. Our first main result lists the possible groups G. In each case we discuss...... the geometry of the action, reduce V to a normal form, find the singular points, study their nature, and calculate the Milnor numbers. The Tjurina number τ(V) ≤ (d − 1) n–2(d 2 − 3d + 3): we call V oversymmetric if this value is attained. We calculate τ in many cases, and characterise the oversymmetric...

Group theoretical treatment of the low-temperature phase transition of the Cd6Ca 1/1-cubic approximant

International Nuclear Information System (INIS)

Tamura, R.; Shibata, K.; Nishimoto, K.; Takeuchi, S.; Edagawa, K.; Saitoh, K.; Isobe, M.; Ueda, Y.

2005-01-01

An antiparallel orientational transition is reported for an intermetallic compound, i.e., Cd 6 Ca crystal, which is a 1/1-1/1-1/1 crystalline approximant to the icosahedral quasicrystal Cd 5.7 Ca. A group theoretical analysis based on the Landau theory predicts that the space group of the low-temperature phase is either C2/c or C2/m, in good agreement with the observations. Accordingly, two types of orientational orderings of Cd 4 tetrahedra, which are located in the center of icosahedral clusters, may occur below 100 K: In both cases, the Cd 4 tetrahedra are orientationally ordered in an antiparallel fashion along the [110] direction of the high temperature body-centered-cubic phase. Such a transition in a metal is reminiscent of orientational transitions in molecular solids

U(N) instantons on N=(1/2) superspace: Exact solution and geometry of moduli space

International Nuclear Information System (INIS)

Britto, Ruth; Feng Bo; Lunin, Oleg; Rey, Soo-Jong

2004-01-01

We construct the exact solution of one (anti-)instanton in N=(1/2) super Yang-Mills theory defined on non(anti-)commutative superspace. We first identify N=(1/2) superconformal invariance as maximal spacetime symmetry. For the gauge group U(2), the SU(2) part of the solution is given by the standard (anti-)instanton, but the U(1) field strength also turns out to be nonzero. The solution is SO(4) rotationally symmetric. For the gauge group U(N), in contrast with the U(2) case, we show that the entire U(N) part of the solution is deformed by non(anti-)commutativity and fermion zero modes. The solution is no longer rotationally symmetric; it is polarized into an axially symmetric configuration because of the underlying non(anti-)commutativity. We compute the 'information metric' of one (anti-)instanton. We find that the moduli space geometry is deformed from the hyperbolic space H 5 (Euclidean anti-de Sitter space) in a way anticipated from reduced spacetime symmetry. Remarkably, the volume measure of the moduli space turns out to be independent of the non(anti-)commutativity. Implications for D branes in the Ramond-Ramond flux background and the gauge-gravity correspondence are discussed

Grain size dependent phase stabilities and presence of a monoclinic (Pm) phase in the MPB region of (1-x)Bi(Mg_1_/_2Ti_1_/_2)O_3_-_xPbTiO_3

International Nuclear Information System (INIS)

Upadhyay, A.; Singh, A.K.

2016-01-01

The results of the room temperature structural studies on (1-x)Bi(Mg_1_/_2Ti_1_/_2)O_3_-_xPbTiO_3 ceramics using Rietveld analysis of the powder X-ray diffraction data in the composition range 0.28≤x≤0.45 are presented. The morphotropic phase boundary region exhibits coexistence of monoclinic (space group Pm) and tetragonal (space group P4mm) phases in the composition range 0.33≤x≤0.40. The structure is nearly single phase monoclinic (space group Pm) in the composition range 0.28≤x≤0.32. The structure for the compositions with x≥0.45 is found to be predominantly tetragonal with space group P4mm. Rietveld refinement of the structure rules out the coexistence of rhombohedral and tetragonal phases in the morphotropic phase boundary region reported by earlier authors. The Rietveld structure analysis for the sample x=0.35 calcined at various temperatures reveals that phase fraction of the coexisting phases in the morphotropic phase boundary region varies with grain size. The structural parameters of the two coexisting phases also change slightly with changing grain size. (author)

Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration.

Science.gov (United States)

Koch, Alexander; Jäger, Manuel; Völzke, Anja; Grammatikos, Georgios; Zu Heringdorf, Dagmar Meyer; Huwiler, Andrea; Pfeilschifter, Josef

2015-06-01

Sphingosine 1-phosphate (S1P) is generated by sphingosine kinase (SK)-1 and -2 and acts mainly as an extracellular ligand at five specific receptors, denoted S1P1-5. After activation, S1P receptors regulate important processes in the progression of renal diseases, such as mesangial cell migration and survival. Previously, we showed that dexamethasone enhances SK-1 activity and S1P formation, which protected mesangial cells from stress-induced apoptosis. Here we demonstrate that dexamethasone treatment lowered S1P1 mRNA and protein expression levels in rat mesangial cells. This effect was abolished in the presence of the glucocorticoid receptor antagonist RU-486. In addition, in vivo studies showed that dexamethasone downregulated S1P1 expression in glomeruli isolated from mice treated with dexamethasone (10 mg/kg body weight). Functionally, we identified S1P1 as a key player mediating S1P-induced mesangial cell migration. We show that dexamethasone treatment significantly lowered S1P-induced migration of mesangial cells, which was again reversed in the presence of RU-486. In summary, we suggest that dexamethasone inhibits S1P-induced mesangial cell migration via downregulation of S1P1. Overall, these results demonstrate that dexamethasone has functional important effects on sphingolipid metabolism and action in renal mesangial cells.

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase.

Directory of Open Access Journals (Sweden)

Evgeny V Berdyshev

Full Text Available BACKGROUND: Earlier we have shown that extracellular sphingosine-1-phosphate (S1P induces migration of human pulmonary artery endothelial cells (HPAECs through the activation of S1P(1 receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade. As endothelial cells generate intracellular S1P, here we have investigated the role of sphingosine kinases (SphKs and S1P lyase (S1PL, that regulate intracellular S1P accumulation, in HPAEC motility. METHODOLOGY/PRINCIPAL FINDINGS: Inhibition of SphK activity with a SphK inhibitor 2-(p-Hydroxyanilino-4-(p-Chlorophenyl Thiazole or down-regulation of Sphk1, but not SphK2, with siRNA decreased S1P(int, and attenuated S1P(ext or serum-induced motility of HPAECs. On the contrary, inhibition of S1PL with 4-deoxypyridoxine or knockdown of S1PL with siRNA increased S1P(int and potentiated motility of HPAECs to S1P(ext or serum. S1P(ext mediates cell motility through activation of Rac1 and IQGAP1 signal transduction in HPAECs. Silencing of SphK1 by siRNA attenuated Rac1 and IQGAP1 translocation to the cell periphery; however, knockdown of S1PL with siRNA or 4-deoxypyridoxine augmented activated Rac1 and stimulated Rac1 and IQGAP1 translocation to cell periphery. The increased cell motility mediated by down-regulation was S1PL was pertussis toxin sensitive suggesting "inside-out" signaling of intracellularly generated S1P. Although S1P did not accumulate significantly in media under basal or S1PL knockdown conditions, addition of sodium vanadate increased S1P levels in the medium and inside the cells most likely by blocking phosphatases including lipid phosphate phosphatases (LPPs. Furthermore, addition of anti-S1P mAb to the incubation medium blocked S1P(ext or 4-deoxypyridoxine-dependent endothelial cell motility. CONCLUSIONS/SIGNIFICANCE: These results suggest S1P(ext mediated endothelial cell motility is dependent on intracellular S1P production, which is regulated, in part, by SphK1 and S1PL.

The role of high mobility group box 1 (HMGB-1) in the diabetic retinopathy inflammation and apoptosis.

Science.gov (United States)

Yu, Yao; Yang, Lu; Lv, Jinlei; Huang, Xu; Yi, Jinglin; Pei, Chonggang; Shao, Yi

2015-01-01

Diabetic Retinopathy (DR) is one of the most common complications of the late phase diabetes, and also a common cause of blindness. High mobility group box 1 (HMGB-1) is considered to be an inflammatory mediator in the late phase that promotes inflammation and neovascularization in diabetes. Therefore, this paper discussed the role of HMGB-1 in diabetic retinopathy inflammation and neovascularization. 96 adult SD rats were randomly divided into control and diabetes group. The diabetic rat model was established by intraperitoneal injection of streptomycin (0.1 mol/L). Western blot was applied to determine HMGB-1 and its receptor RAGE and TLR2 protein expression in the serum. TUNEL was used to detect retinal apoptosis. Immunofluorescence was performed to test HMGB1 protein expression in retina. HBGM-1 and RAGE expression in diabetic rat retina was significantly higher than the control (P detection showed that diabetic rat retinal cells presented obviously higher apoptosis rate (P diabetic rat retinal cells (P diabetic retinopathy by binding with RAGE receptor to accelerate rat retinal cells apoptosis.

Crystallization and preliminary X-ray diffraction analysis of two extracytoplasmic solute receptors of the DctP family from Bordetella pertussis

Energy Technology Data Exchange (ETDEWEB)

Rucktooa, Prakash; Huvent, Isabelle [UMR8161 CNRS Institut de Biologie de Lille, Laboratoire de Cristallographie Macromoléculaire, 1 Rue du Professeur Calmette, BP 447, 59021 Lille CEDEX (France); IFR 142, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, BP 245, 59021 Lille CEDEX (France); Antoine, Rudy; Lecher, Sophie; Jacob-Dubuisson, Françoise, E-mail: francoise.jacob@ibl.fr [IFR 142, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, BP 245, 59021 Lille CEDEX (France); INSERM-U629, Lille (France); Institut Pasteur de Lille, 1 Rue du Professeur Calmette, BP 245, 59021 Lille CEDEX (France); Villeret, Vincent, E-mail: francoise.jacob@ibl.fr; Bompard, Coralie [UMR8161 CNRS Institut de Biologie de Lille, Laboratoire de Cristallographie Macromoléculaire, 1 Rue du Professeur Calmette, BP 447, 59021 Lille CEDEX (France); IFR 142, Institut Pasteur de Lille, 1 Rue du Professeur Calmette, BP 245, 59021 Lille CEDEX (France)

2006-10-01

Sample preparation, crystallization and preliminary X-ray analysis are reported for two B. pertussis extracytoplasmic solute receptors. DctP6 and DctP7 are two Bordetella pertussis proteins which belong to the extracytoplasmic solute receptors (ESR) superfamily. ESRs are involved in the transport of substrates from the periplasm to the cytosol of Gram-negative bacteria. DctP6 and DctP7 have been crystallized and diffraction data were collected using a synchrotron-radiation source. DctP6 crystallized in space group P4{sub 1}2{sub 1}2, with unit-cell parameters a = 108.39, b = 108.39, c = 63.09 Å, while selenomethionyl-derivatized DctP7 crystallized in space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 64.87, b = 149.83, c = 170.65 Å. The three-dimensional structure of DctP7 will be determined by single-wavelength anomalous diffraction, while the DctP6 structure will be solved by molecular-replacement methods.

Gauging of 1D-space translations for nonrelativistic matter - Geometric bags

International Nuclear Information System (INIS)

Stichel, P.C.

2000-01-01

We develop in a systematic fashion the idea of gauging 1D-space translations with fixed Newtonian time for nonrelativistic matter (particles and fields). By starting with a nonrelativistic free theory we obtain its minimal gauge invariant extension by introducing two gauge fields with a Maxwellian self interaction. We fix the gauge so that the residual symmetry group is the Galilei group and construct a representation of the extended Galilei algebra. The reduced N-particle Lagrangian describes geodesic motion in a (N-1)-dimensional (Pseudo-) Riemannian space. The singularity of the metric for negative gauge coupling leads in classical dynamics to the formation of geometric bags in the case of two or three particles. The ordering problem within the quantization scheme for N-particles is solved by canonical quantization of a pseudoclassical Schroedinger theory obtained by adding to the continuum generalization of the point-particle Lagrangian an appropriate quantum correction. We solve the two-particle bound state problem for both signs of the gauge coupling. At the end we speculate on the possible physical relevance of the new interaction induced by the gauge fields

HUBBLE SPACE TELESCOPE OBSERVATIONS OF ACTIVE ASTEROID 324P/La SAGRA

Energy Technology Data Exchange (ETDEWEB)

Jewitt, David; Li, Jing [Department of Earth, Planetary and Space Sciences, UCLA, 595 Charles Young Drive East, Los Angeles, CA 90095-1567 (United States); Agarwal, Jessica [Max Planck Institute for Solar System Research, Justus-von-Liebig-Weg 3, D-37077 Göttingen (Germany); Weaver, Harold [The Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, Maryland 20723 (United States); Mutchler, Max [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Larson, Stephen, E-mail: jewitt@ucla.edu [Lunar and Planetary Laboratory, University of Arizona, 1629 E. University Boulevard, Tucson, AZ 85721-0092 (United States)

2016-09-01

Hubble Space Telescope observations of active asteroid 324P/La Sagra near perihelion show continued mass loss consistent with the sublimation of near-surface ice. Isophotes of the coma measured from a vantage point below the orbital plane are best matched by steady emission of particles having a nominal size  of  a  ∼ 100 μ m. The inferred rate of mass loss, dM{sub d} / dt  ∼ 0.2 kg s{sup −1}, can be supplied by sublimation of water ice in thermal equilibrium with sunlight from an area as small as 930 m{sup 2}, corresponding to about 0.2% of the nucleus surface. Observations taken from a vantage point only 0.°6 from the orbital plane of 324P set a limit to the velocity of ejection of dust in the direction perpendicular to the plane, V {sub ⊥} < 1 m s{sup −1}. Short-term photometric variations of the near-nucleus region, if related to rotation of the underlying nucleus, rule-out periods ≤3.8 hr and suggest that rotation probably does not play a central role in driving the observed mass loss. We estimate that, in the previous orbit, 324P lost about 4 × 10{sup 7} kg in dust particles, corresponding to 6 × 10{sup −5} of the mass of a 550 m spherical nucleus of assumed density ρ  = 1000 kg m{sup −3}. If continued, mass loss at this rate would limit the lifetime of 324P to ∼1.6 × 10{sup 4} orbits (about 10{sup 5} years). To survive for the 100–400 Myr timescales corresponding to dynamical and collisional stability requires a duty cycle of 2 × 10{sup −4} ≤  f{sub d}  ≤ 8 × 10{sup −4}. Unless its time in orbit is overestimated by many orders of magnitude, 324P is revealed as a briefly active member of a vast population of otherwise dormant ice-containing asteroids.

GRIP LANGLEY AEROSOL RESEARCH GROUP EXPERIMENT (LARGE) V1

Data.gov (United States)

National Aeronautics and Space Administration — Langley Aerosol Research Group Experiment (LARGE) measures ultrafine aerosol number density, total and non-volatile aerosol number density, dry aerosol size...

Carcinogenicity of 1-methyl-3(p-chlorophenyl)-1-nitrosourea and its 1-methyl trideuterated derivative in rats.

Science.gov (United States)

Schreiber, D; Martin, J; Mendel, J

1986-01-01

The carcinogenic activity of 1-methyl-3(p-chlorophenyl)-1-nitrosourea (Cl-MPNU) and its 1-methyl trideuterated analog (Cl-MPNU-d3) was compared by intragastric administration to hooded rats of equimolar doses of both compounds. A 100% frequency of forestomach tumors was observed in both groups. However, the mean latency period of the animals treated with Cl-MPNU-d3 was significantly longer (P less than 0.01). The results suggest the occurrence of a deuterium isotope effect in nitrosoureas but not as distinct as in nitrosamines.

Ethane-1,1,2-trisphosphonic acid hemihydrate.

Science.gov (United States)

Delain-Bioton, Lise; Lohier, Jean François; Villemin, Didier; Sopková-de Oliveira Santos, Jana; Hix, Gary; Jaffrès, Paul Alain

2008-02-01

Ethane-1,1,2-trisphosphonic acid crystallizes as a hemihydrate, C(2)H(9)O(9)P(3).0.5H(2)O, in which the water O atom lies on an inversion centre in the space group P2(1)/c. The acid component, which contains a short but noncentred O-H...O hydrogen bond, adopts a gauche conformation. The acid components are linked by an extensive series of O-H...O hydrogen bonds to form layers, which are linked into pairs by the water molecules.

The bicovariant differential calculus on the κ-Poincare group and on the κ-Minkowski space

International Nuclear Information System (INIS)

Kosinski, P.; Maslanka, P.; Sobczyk, J.

1996-01-01

The bicovariant differential calculus on the four-dimensional κ-Poincare group and the corresponding Lie-algebra-like structure are described. The differential calculus on the n-dimensional κ-Minkowski space covariant under the action of the κ-Poincare group was constructed. 5 refs

Local Backbone Flexibility as a Determinant of the Apparent pKa Values of Buried Ionizable Groups in Proteins.

Science.gov (United States)

Peck, Meredith T; Ortega, Gabriel; De Luca-Johnson, Javier N; Schlessman, Jamie L; Robinson, Aaron C; García-Moreno E, Bertrand

2017-10-10

Ionizable groups buried in the hydrophobic interior of proteins are essential for energy transduction. These groups can have highly anomalous pK a values that reflect the incompatibility between charges and dehydrated environments. A systematic study of pK a values of buried ionizable groups in staphylococcal nuclease (SNase) suggests that these pK a values are determined in part by conformational reorganization of the protein. Lys-66 is one of the most deeply buried residues in SNase. We show that its apparent pK a of 5.7 reflects the average of the pK a values of Lys-66 in different conformational states of the protein. In the fully folded state, Lys-66 is deeply buried in the hydrophobic core of SNase and must titrate with a pK a of ≪5.7. In other states, the side chain of Lys-66 is fully solvent-exposed and has a normal pK a of ≈10.4. We show that the pK a of Lys-66 can be shifted from 5.7 toward a more normal value of 7.1 via the insertion of flanking Gly residues at positions 64 and 67 to promote an "open" conformation of SNase. Crystal structures and nuclear magnetic resonance spectroscopy show that in these Gly-containing variants Lys-66 can access bulk water as a consequence of overwinding of the C-terminal end of helix 1. These data illustrate that the apparent pK a values of buried groups in proteins are governed in part by the difference in free energy between different conformational states of the protein and by differences in the pK a values of the buried groups in the different conformations.

(+-Chlorido[(1,2,3,4-η;κP2′-2′-diphenylphosphanyl-2-diphenylphosphoryl-1,1′-binaphthyl]rhodium(I methanol monosolvate

Directory of Open Access Journals (Sweden)

Hans-Joachim Drexler

2012-03-01

Full Text Available In the title complex, [RhCl(C44H32OP2]·CH3OH, the RhI ion is coordinated by a naphthyl group of a partially oxidized 2,2′-bis(diphenylphosphanyl-1,1′-binaphthyl (BINAP ligand in a η4 mode, one P atom of the diphenylphosphanyl group and one Cl atom. The P=O group does not interact with the RhI ion but accepts an O—H...O hydrogen bond from the methanol solvent molecule.

Z-1 Prototype Space Suit Testing Summary

Science.gov (United States)

Ross, Amy

2013-01-01

The Advanced Space Suit team of the NASA-Johnson Space Center performed a series of test with the Z-1 prototype space suit in 2012. This paper discusses, at a summary level, the tests performed and results from those tests. The purpose of the tests were two-fold: 1) characterize the suit performance so that the data could be used in the downselection of components for the Z-2 Space Suit and 2) develop interfaces with the suitport and exploration vehicles through pressurized suit evaluations. Tests performed included isolated and functional range of motion data capture, Z-1 waist and hip testing, joint torque testing, CO2 washout testing, fit checks and subject familiarizations, an exploration vehicle aft deck and suitport controls interface evaluation, delta pressure suitport tests including pressurized suit don and doff, and gross mobility and suitport ingress and egress demonstrations in reduced gravity. Lessons learned specific to the Z-1 prototype and to suit testing techniques will be presented.

Evaluation excitation functions for "2"8Si(n,p)"2"8Al, "3"1P(n,p)"3"1Si, and "1"1"3In(n,γ)"1"1"4"mIn reactions

International Nuclear Information System (INIS)

Zolotarev, K.I.

2014-10-01

Cross section data for "2"8Si(n,p)"2"8Al, "3"1P(n,p)"3"1Si and "1"1"3In(n,γ)"1"1"4"mIn reactions are needed for solving a wide spectrum of scientific and technical tasks. The excitation function of "2"8Si(n,p)"2"8Al reaction refers to the nuclear data involved in fusion reactor design calculations. The "2"8Si(n,p)"2"8Al reaction is interesting also as the monitor reaction for measurements at fusion facilities. Activation detectors on the basis of the 31P(n,p)31Si reaction are commonly used in the reactor dosimetry. The "1"1"3In(n,γ)"1"1"4"mIn reaction is promising regarding reactor dosimetry application for two reasons. First, due to the "1"1"4"mIn decay parameters which are rather suitable for activation measurements. Half-life of "1"1"4"mIn is equal to T_1/_2 = (49.51 ± 0.01) days and gamma spectrum accompanying decay has only one line with energy 190.27 keV and intensity (15.56 ± 0.15)%. Second, the "1"1"3In(n,γ)"1"1"4"mIn reaction rate may be measured by using one activation detector simultaneously with the "1"1"5In(n,γ)"1"1"6"mIn reaction. Preliminary analysis of existing evaluated excitation functions for "2"8Si(n,p)"2"8Al, "3"1P(n,p)"3"1Si and "1"1"3In(n,γ)"1"1"4"mIn reactions show that new evaluations are needed for all above mentioned reactions. This report is devoted to the preparation of the new evaluations of cross sections data and related covariance matrixes of uncertainties for the "2"8Si(n,p)"2"8Al, "3"1P(n,p)"3"1Si and "1"1"3In(n,γ)"1"1"4"mIn reactions.

Augmenting the Funding Sources for Space Science and the ASTRO-1 Space Telescope

Science.gov (United States)

Morse, Jon

2015-08-01

The BoldlyGo Institute was formed in 2013 to augment the planned space science portfolio through philanthropically funded robotic space missions, similar to how some U.S. medical institutes and ground-based telescopes are funded. I introduce BoldlyGo's two current projects: the SCIM mission to Mars and the ASTRO-1 space telescope. In particular, ASTRO-1 is a 1.8-meter off-axis (unobscured) ultraviolet-visible space observatory to be located in a Lagrange point or heliocentric orbit with a wide-field panchromatic camera, medium- and high-resolution spectrograph, and high-contrast imaging coronagraph and/or an accompanying starshade/occulter. It is intended for the post-Hubble Space Telescope era in the 2020s, enabling unique measurements of a broad range of celestial targets, while providing vital complementary capabilities to other ground- and space-based facilities such as the JWST, ALMA, WFIRST-AFTA, LSST, TESS, Euclid, and PLATO. The ASTRO-1 architecture simultaneously wields great scientific power while being technically viable and affordable. A wide variety of scientific programs can be accomplished, addressing topics across space astronomy, astrophysics, fundamental physics, and solar system science, as well as being technologically informative to future large-aperture programs. ASTRO-1 is intended to be a new-generation research facility serving a broad national and international community, as well as a vessel for impactful public engagement. Traditional institutional partnerships and consortia, such as are common with private ground-based observatories, may play a role in the support and governance of ASTRO-1; we are currently engaging interested international organizations. In addition to our planned open guest observer program and accessible data archive, we intend to provide a mechanism whereby individual scientists can buy in to a fraction of the gauranteed observing time. Our next step in ASTRO-1 development is to form the ASTRO-1 Requirements Team

Realization of vector fields for quantum groups as pseudodifferential operators on quantum spaces

International Nuclear Information System (INIS)

Chu, Chong-Sun; Zumino, B.

1995-01-01

The vector fields of the quantum Lie algebra are described for the quantum groups GL q (n), SL q (N) and SO q (N) as pseudodifferential operators on the linear quantum spaces covariant under the corresponding quantum group. Their expressions are simple and compact. It is pointed out that these vector fields satisfy certain characteristic polynomial identities. The real forms SU q (N) and SO q (N,R) are discussed in detail

Interstitial deletion 1p as a result of a de novo reciprocal 1p;2p translocation

DEFF Research Database (Denmark)

Hertz, Jens Michael; Jensen, P H

1985-01-01

A 5-month-old female patient with psychomotor retardation and minor dysmorphisms is described. Cytogenetic analysis using high-resolution banding technique revealed an interstitial deletion of the short arm of one chromosome 1 (p21----p22.2) resulting from a de novo translocation t(1;2)(p22;p25)....

Urinary levels of high mobility group box-1 are associated with disease activity in antineutrophil cytoplasmic autoantibody-associated vasculitis.

Directory of Open Access Journals (Sweden)

Tian-Tian Ma

Full Text Available High mobility group box-1 (HMGB1, a kind of pro-inflammatory mediator, is associated with inflammatory conditions and tissue damage. Our previous study demonstrated that the circulating levels of HMGB1 correlated with disease activity of antineutrophil cytoplasmic antibody (ANCA-associated vasculitis (AAV. In the current study, we aimed to measure urinary levels of HMGB1 in AAV patients, correlated them to clinical activity index and analysed the immunohistochemical HMGB1 staining in kidney specimens.50 patients with AAV in active stage and 56 patients with AAV in remission were recruited. The urinary levels of HMGB1 were determined by enzyme-linked immunosorbent assay. Moreover, renal biopsy specimens from 27 patients with active AAV were randomly collected to evaluate the deposition of HMGB1.Urinary HMGB1 levels in AAV patients in active stage were significantly higher than those in AAV patients in remission and healthy controls (1.46 [0.56-3.43] versus 0.38 [0.10-1.35] mg/μmolCr, P=0.001; 1.46 [0.56-3.43] versus 0.48 [0.40-0.60] mg/μmolCr, P=0.000, respectively. Further analysis found that urinary levels of HMGB1 correlated with erythrocyte sedimentation rate (r=0.354, p=0.012, C-reactive protein (r=0.289, p=0.042, and Birmingham Vasculitis Activity Score (r=0.350, p=0.013. Renal tissue of active AAV patients showed HMGB1 was mainly expressed in the cytoplasm and the extracellular space. The percentage of HMGB1-negative nuclei in renal tissue of patients with active AAV was significantly higher than that in normal controls (60.6±20.2 % versus 2.7±0.6 %, p<0.01.Urinary levels of HMGB1 may be associated with the disease activity in AAV patients.

Update of PHOENIX-P 42 group library from CENDL-2

International Nuclear Information System (INIS)

Zhang Baocheng

1998-01-01

PHOENIX-P is a lattice physics code system, developed by the Westinghouse Electric Corporation (WEC), which was transplanted and used at Dayabay Nuclear Power Plant (DNPJVC). The associated multi-group (42-group) library was derived from the evaluated nuclear data of ENDF/B-5. Since the original library is from the old evaluated nuclear data, it can not meet all the requirements of reactor physics calculations of the nuclear power plant. So it is necessary to update the library with the latest version of evaluated nuclear data. To do so, based on the investigation of the old library and the information about the library, some programs were developed at China Nuclear Data Center (CNDC) to produce PHOENIX-P format data sets mainly from CENDL-2 and the new data were used to supersede the old ones of the PHOENIX-P library

Assessment of space plasma effectsfor satellite applications:Working Group 2 overview

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N. Jakowski

2004-06-01

Full Text Available An important part of the tasks of Working Group 2 of the COST Action 271 «Assessment of space plasma effect for satellites applications» is the assessment of novel data sources for information about the state of ionisation of the ionosphere. This report deals with those aspects which are not represented adequately in the scientific papers in this issue. Here emphasis is given to the product aspect (data and model collections, descriptions of methods and algorithms, availability of products, expected future developments and the links between the past COST Actions 238 and 251 with the present Action 271 and with possible future cooperations. Working Group 2 was leading in the transionospheric propagation aspects of possible products for the International Telecommunication Union?s Radiocommunication (ITU-R Study Group 3. This report gives a short overview emphasizing future developments.

The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation.

Science.gov (United States)

Martins, Telma S; Pereira, Clara; Canadell, David; Vilaça, Rita; Teixeira, Vítor; Moradas-Ferreira, Pedro; de Nadal, Eulàlia; Posas, Francesc; Costa, Vítor

2018-01-01

Iron acquisition systems have to be tightly regulated to assure a continuous supply of iron, since it is essential for survival, but simultaneously to prevent iron overload that is toxic to the cells. In budding yeast, the low‑iron sensing transcription factor Aft1p is a master regulator of the iron regulon. Our previous work revealed that bioactive sphingolipids modulate iron homeostasis as yeast cells lacking the sphingomyelinase Isc1p exhibit an upregulation of the iron regulon. In this study, we show that Isc1p impacts on iron accumulation and localization. Notably, Aft1p is activated in isc1Δ cells due to a decrease in its phosphorylation and an increase in its nuclear levels. Consistently, the expression of a phosphomimetic version of Aft1p-S210/S224 that favours its nuclear export abolished iron accumulation in isc1Δ cells. Notably, the Hog1p kinase, homologue of mammalian p38, interacts with and directly phosphorylates Aft1p at residues S210 and S224. However, Hog1p-Aft1p interaction decreases in isc1Δ cells, which likely contributes to Aft1p dephosphorylation and consequently to Aft1p activation and iron overload in isc1Δ cells. These results suggest that alterations in sphingolipid composition in isc1Δ cells may impact on iron homeostasis by disturbing the regulation of Aft1p by Hog1p. To our knowledge, Hog1p is the first kinase reported to directly regulate Aft1p, impacting on iron homeostasis. Copyright © 2017 Elsevier B.V. All rights reserved.

Resilience to audiogenic seizures is associated with p-ERK1/2 dephosphorylation in the subiculum of Fmr1 knockout mice

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Giulia eCuria

2013-04-01

Full Text Available Young, but not adult, Fmr1 knockout (KO mice display audiogenic seizures (AGS that can be prevented by inhibiting extracellular signal-regulated kinases 1/2 (ERK1/2 phosphorylation. In order to identify the cerebral regions involved in these phenomena, we characterized the response to AGS in Fmr1 KO mice and wild type (WT controls at postnatal day (P 45 and P90. To characterize the diverse response to AGS in various cerebral regions, we evaluated the activity markers FosB/ΔFosB and phosphorylated ERK1/2 (p-ERK1/2. Wild running (100% of tested mice followed by clonic/tonic seizures (30% were observed in P45 Fmr1 KO mice, but not in WT mice. In P90 Fmr1 KO mice, wild running was only present in 25% of tested animals. Basal FosB/ΔFosB immunoreactivity was higher (P<0.01 vs WT in the CA1 and subiculum of P45 Fmr1 KO mice. Following the AGS test, FosB/ΔFosB expression consistently increased in most of the analyzed regions in both groups at P45, but not at P90. Interestingly, FosB/ΔFosB immunoreactivity was significantly higher in P45 Fmr1 KO mice in the medial geniculate body (P<0.05 vs WT and CA3 (P<0.01. Neurons presenting with immunopositivity to p-ERK1/2 were more abundant in the subiculum of Fmr1 KO mice in control condition (P<0.05 vs WT, in both age groups. In this region, p-ERK1/2-immunopositive cells significantly decreased (-75%, P<0.01 in P90 Fmr1 KO mice exposed to the AGS test, but no changes were found in P45 mice or in other brain regions. In both age groups of WT mice, p-ERK1/2-immunopositive cells increased in the subiculum after exposure to the acoustic test. Our findings illustrate that FosB/ΔFosB markers are overexpressed in the medial geniculate body and CA3 in Fmr1 KO mice experiencing AGS, and that p-ERK1/2 is markedly decreased in the subiculum of Fmr1 KO mice resistant to AGS induction. These findings suggest that resilience to AGS is associated with dephosphorylation of p-ERK1/2 in the subiculum of mature Fmr1 KO mice.

EFFECT OF FLOOR SPACE ON SERUM CORTISOL LEVEL OF OSMANABADI KIDS IN MUMBAI REGION OF INDIA

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Rameswar Panda

2016-12-01

Full Text Available This experiment was conducted to find out the effect of different floor space allowance on serum cortisol level of Osmanabadi kids. For this study, eighteen Osmanabadi kids between the age group of 3-4 months were randomly selected irrespective of sex. The selected kids were divided and kept into three different groups with different floor space comprising of 6 kids in each group. GroupT0 (0.8m2 floor space/kid, Group T1 (0.7m2 /kid and Group T2 (0.6m2 /kid. The feeding and other management practices for all the three groups were similar. The blood sample was collected from each goat in fifteen days interval and the serum cortisol concentration (nM/l was determined with the help of Radio Immuno Assay (RIA kit. The average serum cortisol concentration were 12.66 ± 3.08, 10.85 ± 3.51 and 15.18 ± 3.88 nM/l in Group T0, T1 and T2 kids respectively. There was no significant effect (P<0.05 of floor space on cortisol concentration as a stress indicator in Osmanabadi kids.

Estudo de p27, p21, p16 em epitélio escamoso normal, papiloma escamoso e carcinoma de células escamosas da cavidade oral Comparative analysis of the immunohistochemistry expression of p27, p21WAF/Cip1, and p16INK4a in oral normal epithelium, squamous papilloma and squamous cell carcinoma

Directory of Open Access Journals (Sweden)

Ana Beatriz Piazza Queiroz

2009-12-01

infections caused by the human papilloma virus(21. The analysis of medical literature shows changes in cell cycle regulatory genes (p27, p21WAF/Cip1 and p16INK4a, but does not define their roles in oral carcinogenesis. Objective: Characterize the immuno-histochemical expression of p27, p21WAF/Cip1 and p16INK4a in oral normal squamous epithelium, oral squamous papilloma and oral squamous cell carcinoma. METHODS: Immuno-histochemical evaluation of p27, p21WAF/Cip1 and p16INK4a in 32 samples of oral normal squamous epithelium, 30 of oral squamous papilloma and 34 of oral squamous cell carcinoma. RESULTS: 97.06% of the oral squamous cell carcinoma group, 33.33% of the squamous papilloma group and 18.75% of the control group showed focal immunopositivity for p27. 100% of both control and oral squamous cell carcinoma groups and 90% of the oral squamous papilloma group showed focal immunopositivity for p21WAF/Cip1. 100% of both control and oral squamous papilloma groups and 94% of the oral squamous cell carcinoma group showed focal immunopositivity for p16INK4a. CONCLUSIONS: The study revealed a statistically significant difference for p27 expression when comparing the control and oral squamous papilloma groups with the oral squamous cell carcinoma group. p21WAF/Cip1 did not prove to be useful to differentiate the groups. p16INK4a showed diffuse immunopositivity in a minority of the oral squamous cell carcinoma cases. The oral squamous papilloma group behaved similarly to the control group as to the three markers.

Inner Functions in Lipschitz, Besov, and Sobolev Spaces

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Daniel Girela

2011-01-01

Full Text Available We study the membership of inner functions in Besov, Lipschitz, and Hardy-Sobolev spaces, finding conditions that enable an inner function to be in one of these spaces. Several results in this direction are given that complement or extend previous works on the subject from different authors. In particular, we prove that the only inner functions in either any of the Hardy-Sobolev spaces Hαp with 1/p≤α<∞ or any of the Besov spaces Bαp,  q with 0<p,q≤∞ and α≥1/p, except when p=∞, α=0, and 2p<∞, q=∞, and α=1/p are finite Blaschke products. Our assertion for the spaces B0∞,q, 0space VMOA. We prove also that for 2space contains infinite Blaschke products. Furthermore, we obtain distinct results for other values of α relating the membership of an inner function I in the spaces under consideration with the distribution of the sequences of preimages {I-1(a}, |a|<1. In addition, we include a section devoted to Blaschke products with zeros in a Stolz angle.

NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity.

Science.gov (United States)

Chylack, Leo T; Peterson, Leif E; Feiveson, Alan H; Wear, Mary L; Manuel, F Keith; Tung, William H; Hardy, Dale S; Marak, Lisa J; Cucinotta, Francis A

2009-07-01

The NASA Study of Cataract in Astronauts (NASCA) is a 5-year longitudinal study of the effect of space radiation exposure on the severity/progression of nuclear, cortical and posterior subcapsular (PSC) lens opacities. Here we report on baseline data that will be used over the course of the longitudinal study. Participants include 171 consenting astronauts who flew at least one mission in space and a comparison group made up of three components: (a) 53 astronauts who had not flown in space, (b) 95 military aircrew personnel, and (c) 99 non-aircrew ground-based comparison subjects. Continuous measures of nuclear, cortical and PSC lens opacities were derived from Nidek EAS 1000 digitized images. Age, demographics, general health, nutritional intake and solar ocular exposure were measured at baseline. Astronauts who flew at least one mission were matched to comparison subjects using propensity scores based on demographic characteristics and medical history stratified by gender and smoking (ever/never). The cross-sectional data for matched subjects were analyzed by fitting customized non-normal regression models to examine the effect of space radiation on each measure of opacity. The variability and median of cortical cataracts were significantly higher for exposed astronauts than for nonexposed astronauts and comparison subjects with similar ages (P=0.015). Galactic cosmic space radiation (GCR) may be linked to increased PSC area (P=0.056) and the number of PSC centers (P=0.095). Within the astronaut group, PSC size was greater in subjects with higher space radiation doses (P=0.016). No association was found between space radiation and nuclear cataracts. Cross-sectional data analysis revealed a small deleterious effect of space radiation for cortical cataracts and possibly for PSC cataracts. These results suggest increased cataract risks at smaller radiation doses than have been reported previously.

SiP monolayers: New 2D structures of group IV-V compounds for visible-light photohydrolytic catalysts

Science.gov (United States)

Ma, Zhinan; Zhuang, Jibin; Zhang, Xu; Zhou, Zhen

2018-06-01

Because of graphene and phosphorene, two-dimensional (2D) layered materials of group IV and group V elements arouse great interest. However, group IV-V monolayers have not received due attention. In this work, three types of SiP monolayers were computationally designed to explore their electronic structure and optical properties. Computations confirm the stability of these monolayers, which are all indirect-bandgap semiconductors with bandgaps in the range 1.38-2.21 eV. The bandgaps straddle the redox potentials of water at pH = 0, indicating the potential of the monolayers for use as watersplitting photocatalysts. The computed optical properties demonstrate that certain monolayers of SiP 2D materials are absorbers of visible light and would serve as good candidates for optoelectronic devices.

NHSBSP type 1 interval cancers: a scientifically valid grouping?

International Nuclear Information System (INIS)

Porter, G.J.R.; Evans, A.J.; Burrell, H.C.; Lee, A.H.S.; Chakrabarti, J.

2007-01-01

Aim: To assess whether there are differences in the pathological features or survival between the new National Health Service Breast Screening Programme (NHSBSP) interval cancer classification system category of type 1 interval cancers, and the previously used, separate categories of occult, unclassified, and true interval cancers. Materials and methods: The prognostic pathological features (grade, lymph node stage, size, vascular invasion, oestrogen receptor status, and histological type) and survival of 428 type 1 interval invasive breast cancers were analysed by subgroup (occult, unclassified and true interval). Results: Occult cancers compared with other type 1 interval cancers were of significantly lower grade [38 of 52 (73%) versus 151 of 340 (44%) grade 1 or 2, p = 0.0005], more likely to be smaller size [37 of 51 (73%) versus 158 of 341 (46%) <20 mm, p = 0.0003] and more frequently of lobular type at histology [14 of 42 (32%) versus 50 of 286 (17%), p = 0.03]. There was no significant difference in pathological features of unclassified tumours compared with other type 1 tumours. There was no significant survival difference between different type 1 subgroups (p = 0.12). Conclusion: The NHSBSP type 1 interval cancers are a heterogeneous grouping with markedly differing pathological features. However, no significant survival difference is seen between the different type 1 subgroups

NHSBSP type 1 interval cancers: a scientifically valid grouping?

Energy Technology Data Exchange (ETDEWEB)

Porter, G.J.R. [Nottingham Breast Institute, City Hospital, Nottingham (United Kingdom)]. E-mail: garethporter@doctors.org.uk; Evans, A.J. [Nottingham Breast Institute, City Hospital, Nottingham (United Kingdom); Burrell, H.C. [Nottingham Breast Institute, City Hospital, Nottingham (United Kingdom); Lee, A.H.S. [Nottingham Breast Institute, City Hospital, Nottingham (United Kingdom); Chakrabarti, J. [Nottingham Breast Institute, City Hospital, Nottingham (United Kingdom)

2007-03-15

Aim: To assess whether there are differences in the pathological features or survival between the new National Health Service Breast Screening Programme (NHSBSP) interval cancer classification system category of type 1 interval cancers, and the previously used, separate categories of occult, unclassified, and true interval cancers. Materials and methods: The prognostic pathological features (grade, lymph node stage, size, vascular invasion, oestrogen receptor status, and histological type) and survival of 428 type 1 interval invasive breast cancers were analysed by subgroup (occult, unclassified and true interval). Results: Occult cancers compared with other type 1 interval cancers were of significantly lower grade [38 of 52 (73%) versus 151 of 340 (44%) grade 1 or 2, p = 0.0005], more likely to be smaller size [37 of 51 (73%) versus 158 of 341 (46%) <20 mm, p = 0.0003] and more frequently of lobular type at histology [14 of 42 (32%) versus 50 of 286 (17%), p = 0.03]. There was no significant difference in pathological features of unclassified tumours compared with other type 1 tumours. There was no significant survival difference between different type 1 subgroups (p = 0.12). Conclusion: The NHSBSP type 1 interval cancers are a heterogeneous grouping with markedly differing pathological features. However, no significant survival difference is seen between the different type 1 subgroups.

Expanding P450 catalytic reaction space through evolution and engineering

Science.gov (United States)

McIntosh, John A.; Farwell, Christopher C.; Arnold, Frances H.

2014-01-01

Advances in protein and metabolic engineering have led to wider use of enzymes to synthesize important molecules. However, many desirable transformations are not catalyzed by any known enzyme, driving interest in understanding how new enzymes can be created. The cytochrome P450 enzyme family, whose members participate in xenobiotic metabolism and natural products biosynthesis, catalyzes an impressive range of difficult chemical reactions that continues to grow as new enzymes are characterized. Recent work has revealed that P450-derived enzymes can also catalyze useful reactions previously accessible only to synthetic chemistry. The evolution and engineering of these enzymes provides an excellent case study for how to genetically encode new chemistry and expand biology’s reaction space. PMID:24658056

Fourier-space TEM reconstructions with symmetry adapted functions for all rotational point groups.

Science.gov (United States)

Trapani, Stefano; Navaza, Jorge

2013-05-01

A general-purpose and simple expression for the coefficients of symmetry adapted functions referred to conveniently oriented symmetry axes is given for all rotational point groups. The expression involves the computation of reduced Wigner-matrix elements corresponding to an angle specific to each group and has the computational advantage of leading to Fourier-space TEM (transmission electron microscopy) reconstruction procedures involving only real valued unknowns. Using this expression, a protocol for ab initio view and center assignment and reconstruction so far used for icosahedral particles has been tested with experimental data in other point groups. Copyright © 2013 Elsevier Inc. All rights reserved.

The Community-based Organizations Working Group of the Space Science Education Support Network

Science.gov (United States)

Lutz, J. H.; Lowes, L. L.; Asplund, S.

2004-12-01

The NASA Space Science Support Network Community-based Organizations Working Group (CBOWG) has been working for the past two years on issues surrounding afterschool programs and programs for youth (e.g., Girl Scouts, Boy Scouts, Boys and Girls Clubs, 4-H, summer camps, afterschool and weekend programs for various ages, programs with emphases on minority youth). In this session the co-leaders of the CBOWG will discuss the challenges of working with community-based organizations on a regional or national level. We will highlight some ties that we have forged with the National Institute for Out of School Time (NIOST) and the National Afterschool Association (NAA). We will also talk about efforts to coordinate how various entities within NASA cooperate with community-based organizations to serve the best interests of these groups. We will give a couple of examples of how NASA space science organizations have partnered with community-based organizations. The session will include some handouts of information and resources that the CBOWG has found useful in developing an understanding of this segment of informal education groups. We would like to thank NASA for providing resources to support the work of the CBOWG.

14 CFR 401.1 - The Office of Commercial Space Transportation.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false The Office of Commercial Space Transportation. 401.1 Section 401.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL ORGANIZATION AND DEFINITIONS § 401.1 The Office of Commercial Space Transportation. The Office of...

Anti-liver-kidney microsome antibody type 1 recognizes human cytochrome P450 db1.

Science.gov (United States)

Gueguen, M; Yamamoto, A M; Bernard, O; Alvarez, F

1989-03-15

Anti-liver-kidney microsome antibody type 1 (LKM1), present in the sera of a group of children with autoimmune hepatitis, was recently shown to recognize a 50 kDa protein identified as rat liver cytochromes P450 db1 and db2. High homology between these two members of the rat P450 IID subfamily and human P450 db1 suggested that anti-LKM1 antibody is directed against this human protein. To test this hypothesis, a human liver cDNA expression library in phage lambda GT-11 was screened using rat P450 db1 cDNA as a probe. Two human cDNA clones were found to be identical to human P450 db1 by restriction mapping. Immunoblot analysis using as antigen, the purified fusion protein from one of the human cDNA clones showed that only anti-LKM1 with anti-50 kDa reactivity recognized the fusion protein. This fusion protein was further used to develop an ELISA test that was shown to be specific for sera of children with this disease. These results: 1) identify the human liver antigen recognized by anti-LKM1 auto-antibodies as cytochrome P450 db1, 2) allow to speculate that mutation on the human P450 db1 gene could alter its expression in the hepatocyte and make it auto-antigenic, 3) provide a simple and specific diagnostic test for this disease.

THERMOS, Space-Dependent Thermal Flux in 1-D Slab or Cylinder

International Nuclear Information System (INIS)

Honeck, Henry C.

2001-01-01

1 - Nature of physical problem solved: Computes the scalar thermal neutron spectrum as function of position in a one-dimensional slab (THERMOS-1) or cylindrical cell (THERMOS-2). Isotropic neutron scattering in the laboratory system is assumed. The slowing down source is computed from elastic scattering of the neutrons in a 1/E epithermal flux. Either a reflecting or vacuum boundary can be chosen. 2 - Method of solution: The velocity and space variables are replaced by discrete values. Scattering and collision probability matrices are computed and the neutron balance equation is solved by iterative techniques. A combination of a Gauss iteration, renormalization and extrapolation is used to accelerate convergence. 3 - Restrictions on the complexity of the problem: Maximum 30 velocity groups, 20 space points, 5 mixtures (assigned arbitrarily to the space points) composed of maximum 10 isotopes. An additional 10 isotopes can be specified for activation calculations and cross section averaging. The Library has received the 7090 version of this programme through the CETIS programmotheque. The 7040 version was written by the Universite libre de Bruxelles. ALGOL version was offered by Delft (Reactor Instituut Delft, Netherlands). A version for ICL computer was received from Central Research Institute for Physics of the Hungarian Academy of Sciences Budapest, Hungary

Function spaces, 1

CERN Document Server

Pick, Luboš; John, Oldrich; Fucík, Svatopluk

2012-01-01

This is the first part of the second revised and extended edition of a well established monograph. It is an introduction to function spaces defined in terms of differentiability and integrability classes. It provides a catalogue of various spaces and benefits as a handbook for those who use function spaces to study other topics such as partial differential equations. Volum

Flow rate, pH and calcium concentration of saliva of children and adolescents with type 1 diabetes mellitus.

Science.gov (United States)

Moreira, A R; Passos, I A; Sampaio, F C; Soares, M S M; Oliveira, R J

2009-08-01

Alterations in salivary parameters may increase the caries risk in diabetic children, but, contradictory data on this issue have been reported. The aims of this study were to compare salivary parameters (flow rate, pH and calcium concentration) between healthy and type 1 diabetes mellitus (T1DM) individuals. The sample consisted of 7- to 18-year-old individuals divided into two groups: 30 subjects with T1DM (group A) and 30 healthy control subjects (group B). Fasting glucose levels were determined. Unstimulated and stimulated saliva was collected. The pH of unstimulated saliva was measured with paper strips and an electrode. Calcium concentrations in stimulated saliva were determined with a selective electrode. Group A individuals had inadequate blood glucose control (HbA(1C) >9%), with means +/- SD unstimulated salivary flow rate of 0.15 +/- 0.1 mL/min compared to 0.36 +/- 0.2 mL/min for group B (P salivary flow rate was similar by both groups and above 2.0 mL/min. Saliva pH was 6.0 +/- 0.8 for group A and significantly different from 7.0 +/- 0.6 for group B (P Salivary calcium was 14.7 +/- 8.1 mg/L for group A and significantly higher than 9.9 +/- 6.4 mg/L for group B (P salivary parameters favoring caries such as low saliva pH and unstimulated salivary flow rate were observed in T1DM individuals.

Comparison of the Cc and R3c space groups for the superlattice phase of Pb(Zr0.52Ti0.48)O3

International Nuclear Information System (INIS)

Ranjan, Rajeev; Singh, Akhilesh Kumar; Ragini; Pandey, Dhananjai

2005-01-01

Recent controversy about the space group of the low temperature superlattice phase of Pb(Zr 0.52 Ti 0.48 )O 3 is settled. It is shown that the R3c space group for the superlattice phase cannot correctly account for the peak positions of the superlattice reflections present in the neutron diffraction patterns. The correct space group is reconfirmed to be Cc. A comparison of the atomic coordinates of Cc and Cm space groups is also presented to show that in the absence of superlattice reflections, as is the case with x-ray diffraction data, one would land up in the Cm space group. This superlattice phase is found to coexist with another monoclinic phase of the Cm space group

Genotyping of Mycoplasma pneumoniae clinical isolates reveals eight P1 subtypes within two genomic groups

NARCIS (Netherlands)

Dorigo-Zetsma, J. W.; Dankert, J.; Zaat, S. A.

2000-01-01

Three methods for genotyping of Mycoplasma pneumoniae clinical isolates were applied to 2 reference strains and 21 clinical isolates. By a modified restriction fragment length polymorphism (RFLP) analysis of PCR products of the M. pneumoniae cytadhesin P1 gene, 5 subtypes were discriminated among 13

On infinite-dimensional state spaces

International Nuclear Information System (INIS)

Fritz, Tobias

2013-01-01

It is well known that the canonical commutation relation [x, p]=i can be realized only on an infinite-dimensional Hilbert space. While any finite set of experimental data can also be explained in terms of a finite-dimensional Hilbert space by approximating the commutation relation, Occam's razor prefers the infinite-dimensional model in which [x, p]=i holds on the nose. This reasoning one will necessarily have to make in any approach which tries to detect the infinite-dimensionality. One drawback of using the canonical commutation relation for this purpose is that it has unclear operational meaning. Here, we identify an operationally well-defined context from which an analogous conclusion can be drawn: if two unitary transformations U, V on a quantum system satisfy the relation V −1 U 2 V=U 3 , then finite-dimensionality entails the relation UV −1 UV=V −1 UVU; this implication strongly fails in some infinite-dimensional realizations. This is a result from combinatorial group theory for which we give a new proof. This proof adapts to the consideration of cases where the assumed relation V −1 U 2 V=U 3 holds only up to ε and then yields a lower bound on the dimension.

On infinite-dimensional state spaces

Science.gov (United States)

Fritz, Tobias

2013-05-01

It is well known that the canonical commutation relation [x, p] = i can be realized only on an infinite-dimensional Hilbert space. While any finite set of experimental data can also be explained in terms of a finite-dimensional Hilbert space by approximating the commutation relation, Occam's razor prefers the infinite-dimensional model in which [x, p] = i holds on the nose. This reasoning one will necessarily have to make in any approach which tries to detect the infinite-dimensionality. One drawback of using the canonical commutation relation for this purpose is that it has unclear operational meaning. Here, we identify an operationally well-defined context from which an analogous conclusion can be drawn: if two unitary transformations U, V on a quantum system satisfy the relation V-1U2V = U3, then finite-dimensionality entails the relation UV-1UV = V-1UVU; this implication strongly fails in some infinite-dimensional realizations. This is a result from combinatorial group theory for which we give a new proof. This proof adapts to the consideration of cases where the assumed relation V-1U2V = U3 holds only up to ɛ and then yields a lower bound on the dimension.

Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation.

Science.gov (United States)

Tsai, Hsing-Chuan; Han, May H

2016-07-01

Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are ubiquitously expressed. S1P-S1PR signaling has been well characterized in immune trafficking and activation in innate and adaptive immune systems. However, the full extent of its involvement in the pathogenesis of autoimmune diseases is not well understood. FTY720 (fingolimod), a non-selective S1PR modulator, significantly decreased annualized relapse rates in relapsing-remitting multiple sclerosis (MS). FTY720, which primarily targets S1P receptor 1 as a functional antagonist, arrests lymphocyte egress from secondary lymphoid tissues and reduces neuroinflammation in the central nervous system (CNS). Recent studies suggest that FTY720 also decreases astrogliosis and promotes oligodendrocyte differentiation within the CNS and may have therapeutic benefit to prevent brain atrophy. Since S1P signaling is involved in multiple immune functions, therapies targeting S1P axis may be applicable to treat autoimmune diseases other than MS. Currently, over a dozen selective S1PR and S1P pathway modulators with potentially superior therapeutic efficacy and better side-effect profiles are in the pipeline of drug development. Furthermore, newly characterized molecules such as apolipoprotein M (ApoM) (S1P chaperon) and SPNS2 (S1P transporter) are also potential targets for treatment of autoimmune diseases. Finally, the application of therapies targeting S1P and S1P signaling pathways may be expanded to treat several other immune-mediated disorders (such as post-infectious diseases, post-stroke and post-stroke dementia) and inflammatory conditions beyond their application in primary autoimmune diseases.

Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma.

Science.gov (United States)

Rodriguez, A M; Graef, A J; LeVine, D N; Cohen, I R; Modiano, J F; Kim, J-H

2015-01-01

Sphingosine-1-phosphate (S1P) is a key biolipid signaling molecule that regulates cell growth and survival, but it has not been studied in tumors from dogs. S1P/S1P1 signaling will contribute to the progression of hemangiosarcoma (HSA). Thirteen spontaneous HSA tissues, 9 HSA cell lines, 8 nonmalignant tissues, including 6 splenic hematomas and 2 livers with vacuolar degeneration, and 1 endothelial cell line derived from a dog with splenic hematoma were used. This was a retrospective case series and in vitro study. Samples were obtained as part of medically necessary diagnostic procedures. Microarray, qRT-PCR, immunohistochemistry, and immunoblotting were performed to examine S1P1 expression. S1P concentrations were measured by high-performance liquid chromatography/mass spectrometry. S1P signaling was evaluated by intracellular Ca(2+) mobilization; proliferation and survival were evaluated using the MTS assay and Annexin V staining. Canine HSA cells expressed higher levels of S1P1 mRNA than nonmalignant endothelial cells. S1P1 protein was present in HSA tissues and cell lines. HSA cells appeared to produce low levels of S1P, but they selectively consumed S1P from the culture media. Exogenous S1P induced an increase in intracellular calcium as well as increased proliferation and viability of HSA cells. Prolonged treatment with FTY720, an inhibitor of S1P1 , decreased S1P1 protein expression and induced apoptosis of HSA cells. S1P/S1P1 signaling pathway functions to maintain HSA cell viability and proliferation. The data suggest that S1P1 or the S1P pathway in general could be targets for therapeutic intervention for dogs with HSA. Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

Science.gov (United States)

Berdyshev, Evgeny V.; Gorshkova, Irina; Usatyuk, Peter; Kalari, Satish; Zhao, Yutong; Pyne, Nigel J.; Pyne, Susan; Sabbadini, Roger A.; Garcia, Joe G. N.; Natarajan, Viswanathan

2011-01-01

Background Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P1 receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade. As endothelial cells generate intracellular S1P, here we have investigated the role of sphingosine kinases (SphKs) and S1P lyase (S1PL), that regulate intracellular S1P accumulation, in HPAEC motility. Methodology/Principal Findings Inhibition of SphK activity with a SphK inhibitor 2-(p-Hydroxyanilino)-4-(p-Chlorophenyl) Thiazole or down-regulation of Sphk1, but not SphK2, with siRNA decreased S1Pint, and attenuated S1Pext or serum-induced motility of HPAECs. On the contrary, inhibition of S1PL with 4-deoxypyridoxine or knockdown of S1PL with siRNA increased S1Pint and potentiated motility of HPAECs to S1Pext or serum. S1Pext mediates cell motility through activation of Rac1 and IQGAP1 signal transduction in HPAECs. Silencing of SphK1 by siRNA attenuated Rac1 and IQGAP1 translocation to the cell periphery; however, knockdown of S1PL with siRNA or 4-deoxypyridoxine augmented activated Rac1 and stimulated Rac1 and IQGAP1 translocation to cell periphery. The increased cell motility mediated by down-regulation was S1PL was pertussis toxin sensitive suggesting “inside-out” signaling of intracellularly generated S1P. Although S1P did not accumulate significantly in media under basal or S1PL knockdown conditions, addition of sodium vanadate increased S1P levels in the medium and inside the cells most likely by blocking phosphatases including lipid phosphate phosphatases (LPPs). Furthermore, addition of anti-S1P mAb to the incubation medium blocked S1Pext or 4-deoxypyridoxine-dependent endothelial cell motility. Conclusions/Significance These results suggest S1Pext mediated endothelial cell motility is dependent on intracellular S1P production, which is regulated, in part, by SphK1 and S1PL. PMID:21304987

P-n junction diodes with polarization induced p-type graded InxGa1-xN layer

Science.gov (United States)

Enatsu, Yuuki; Gupta, Chirag; Keller, Stacia; Nakamura, Shuji; Mishra, Umesh K.

2017-10-01

In this study, p-n junction diodes with polarization induced p-type layer are demonstrated on Ga polar (0001) bulk GaN substrates. A quasi-p-type region is obtained by linearly grading the indium composition in un-doped InxGa1-xN layers from 0% to 5%, taking advantage of the piezoelectric and spontaneous polarization fields which exist in group III-nitride heterostructures grown in the typical (0001) or c-direction. The un-doped graded InxGa1-xN layers needed to be capped with a thin Mg-doped InxGa1-xN layer to make good ohmic contacts and to reduce the on-resistance of the p-n diodes. The Pol-p-n junction diodes exhibited similar characteristics compared to reference samples with traditional p-GaN:Mg layers. A rise in breakdown voltage from 30 to 110 V was observed when the thickness of the graded InGaN layer was increased from 100 to 600 nm at the same grade composition.

Harmonic analysis and global solvability of a differential operator invariant on motion groups and semi-simple Lie groups

International Nuclear Information System (INIS)

El-Hussein, K.

1991-08-01

Let V be a real finite dimensional vector space and let K be a connected compact Lie group, which acts on V by means of a continuous linear representation ρ. Let G=V x p K be the motion group which is the semi-direct product of V by K and let P be an invariant differential operator on G. In this paper we give a necessary and sufficient condition for the global solvability of P on G. Now let G be a connected semi-simple Lie group with finite centre and let P be an invariant differential operator on G. We give also a necessary and sufficient condition for the global solvability of P on G. (author). 8 refs

Synthesis, structural characterization, and thermal stability studies of heteroleptic cadmium(II) dithiocarbamate with different pyridyl groups

Science.gov (United States)

Onwudiwe, Damian C.; Hosten, Eric C.

2018-01-01

The synthesis, characterization and crystal structures of three chloroform solvated adducts of cadmium with mixed ligands of N-alkyl-N-phenyldithiocarbamate and pyridine, 2,2-bipyridine and 1, 10 phenanthroline represented as [CdL1L2 (py)2]·CHCl3(1), [CdL1L2bpy]•CHCl3(2), and [CdL1L2phen]•CHCl3(3) (LI = N-methyl-N-phenyldithiocarbamate, L2 = N-ethyl-N-phenyldithiocarbamate, py = pyridine, bpy = 2,2-bipyridine and phen = 1,10-phenanthroline) respectively are reported. Complex 1, which crystallized in the monoclinic space group P-1, is a centrosymmetric dimeric structure where each Cd center is bonded to two monodentate pyridine, a bidentate terminal dithiocarbamate, and another bidentate bridging dithiocarbamate to form a four-membered ring. Complex 2 crystallized in the monoclinic space group P21/c, with four discrete monomeric molecules in the asymmetric unit. The structure presents a cadmium atom coordinated by two sulphur atoms of a dithiocarbamate ligand and two nitrogen atoms of the 2,2‧-bipyridine to form a CdS4N2 fragment, thus giving the structure around the Cd atom a distorted trigonal prism geometry. Complex 3 contains two discrete monomeric molecules of (phenanthroline) (N, N-methyl phenyl-N, N-ethyl phenyl dithiocarbamato)cadmium (II) per unit cell, and the complex crystallized in the triclinic space group P-1. The structure showed that the Cd atom is bonded to two bidentate dithiocarbamate ligands and to one bidentate phenanthroline ligand in a distorted trigonal prism geometry. All the compounds resulted in CdS as residue upon thermal decomposition process conducted under inert atmosphere.

Temperature Increase during Different Post Space Preparation Systems: An In Vitro Study.

Science.gov (United States)

Nazari Moghadam, Kiumars; Shahab, Shahriar; Shirvani, Soghra; Kazemi, Ali

2011-01-01

  The purpose of this study was to evaluate external root surface temperature rise during post space preparation using LA Axxess bur, Beefill pack System, and Peeso Reamer drill. The distal canals of forty-five extracted human permanent mandibular first molars were instrumented in crown-apical manner and obturated with lateral condensation technique. Teeth were then randomly divided into three groups according to post space preparation technique including: group 1. LA Axxess bur (Sybronendo Co., CA, USA), group 2 Beefill pack System (VD W Co., Munich, Germany) and group 3 Peeso Reamer drill (Mani Co., Tochigi-ken, Japan). Temperature was measured by means of digital thermometer MT-405 (Comercio Co., Sao Paulo, Brazil) which was installed on the root surfaces. Data was collected and submitted to one-way ANOVA and Post hoc analysis. Root surface temperatures were found to be significantly higher (7.3±2.7 vs. 4.3±2.1 and 4±2.4,) in samples of Beefill pack System compared with the two other groups (P<0.02). Using Beefill pack System during post space preparation may be potentially hazardous for periodontal tissues.

Organizational requirements of the SaeR binding sites for a functional P1 promoter of the sae operon in Staphylococcus aureus.

Science.gov (United States)

Cho, Hoonsik; Jeong, Do-Won; Li, Chunling; Bae, Taeok

2012-06-01

In Staphylococcus aureus, the SaeRS two-component system controls the expression of multiple virulence factors. Of the two promoters in the sae operon, P1 is autoinduced and has two binding sites for the response regulator SaeR. In this study, we examined the organizational requirements of the SaeR binding sites in P1 for transcription activation. Mutational studies showed that both binding sites are essential for binding to phosphorylated SaeR (P-SaeR) and transcription activation. When the 21-bp distance between the centers of the two SaeR binding sites was altered to 26 bp, 31 bp, 36 bp, or 41 bp, only the 31-bp mutant retained approximately 40% of the original promoter activity. When the -1-bp spacing (i.e.,1-bp overlap) between the primary SaeR binding site and the -35 promoter region was altered, all mutant P1 promoters failed to initiate transcription; however, when the first nucleotide of the -35 region was changed from A to T, the mutants with 0-bp or 22-bp spacing showed detectable promoter activity. Although P-SaeR was essential for the binding of RNA polymerase to P1, it was not essential for the binding of the enzyme to the alpha-hemolysin promoter. When the nonoptimal spacing between promoter elements in P1 or the coagulase promoter was altered to the optimal spacing of 17 bp, both promoters failed to initiate transcription. These results suggest that SaeR binding sites are under rather strict organizational restrictions and provide clues for understanding the molecular mechanism of sae-mediated transcription activation.

Wilson's disease: 31P and 1H MR spectroscopy and clinical correlation

International Nuclear Information System (INIS)

Sinha, Sanjib; Taly, A.B.; Prashanth, L.K.; Ravishankar, S.; Vasudev, M.K.

2010-01-01

Proton ( 1 H) magnetic resonance spectroscopy (MRS) changes are noted in Wilson's disease (WD). However, there are no studies regarding membrane phospholipid abnormality using 31 P MRS in these patients. We aimed to analyze the striatal spectroscopic abnormalities using 31 P and 1 H MRS in WD. Forty patients of WD (treated, 29; untreated,11) and 30 controls underwent routine MR image sequences and in vivo 2-D 31 P and 1 H MRS of basal ganglia using an image-selected technique on a 1.5-T MRI scanner. Statistical analysis was done using Student's t test. The mean durations of illness and treatment were 6.2 ± 7.4 and 4.8 ± 5.9 years, respectively. MRI images were abnormal in all the patients. 1 H MRS revealed statistically significant reduction of N-acetyl aspartate (NAA)/choline (Cho) and NAA/creatine ratios in striatum ( 1 H MRS) of treated patients compared to controls. The mean values of phosphomonoesters (PME) (p 31 P MRS study. The duration of illness correlated well with increased PME/PDE [p < 0.001], PME/TPh [p < 0.05], and PDE/TPh [p < 0.05] and decreased NAA/Cho [p < 0.05] ratios. There was correlation of MRI score and reduced NAA/Cho ratio with disease severity. The PME/PDE ratio (right) was elevated in the treated group [p < 0.001] compared to untreated group. There is reduced breakdown and/or increased synthesis of membrane phospholipids and increased neuronal damage in basal ganglia in patients with WD. (orig.)

Phylogenetic relationships and biogeography of Ptilophora (Gelidiales, Rhodophyta) with descriptions of P. aureolusa, P. malagasya, and P. spongiophila from Madagascar.

Science.gov (United States)

Boo, Ga Hun; Gall, Line Le; Hwang, Il Ki; Miller, Kathy Ann; Boo, Sung Min

2018-04-01

The genus Ptilophora currently includes 16 species occurring mostly in subtidal habitats of the Indo-Pacific Ocean, but its global diversity and biogeography are poorly understood. We analyzed mitochondrial cox1, plastid rbcL and plastid psbA sequences from specimens collected in southern Madagascar during the 2010 Atimo Vatae expedition and studied their morphologies. Both morphological and molecular data sets demonstrated the presence of five species in southern Madagascar: Ptilophora hildebrandtii, P. pterocladioides, and three new species described here, P. aureolusa, P. malagasya, and P. spongiophila. Ptilophora aureolusa is distinguished by its compound pinnae with uniformly spaced pinnules. Ptilophora malagasya has an indistinct midrib and irregularly spaced pinnules. Ptilophora spongiophila, heavily coated with sponges, has cylindrical to flattened main axes, lateral and surface proliferations, and spatulate tetrasporangial sori. The species of Ptilophora found in Madagascar are endemic, except P. hildebrandtii, which also occurs in eastern Africa. Ptilophora comprises four phylogenetic groups that map to eastern Australia, Japan, western Australia/Southeast Asia/Madagascar/eastern Africa, and Madagascar/eastern Africa/Aegean Sea. Biogeographical analysis revealed that the ancestor of Ptilophora originated in Australia, but most of the species radiated from Madagascar. © 2018 Phycological Society of America.

Implementation of small group discussion as a teaching method in earth and space science subject

Science.gov (United States)

Aryani, N. P.; Supriyadi

2018-03-01

In Physics Department Universitas Negeri Semarang, Earth and Space Science subject is included in the curriculum of the third year of physics education students. There are various models of teaching earth and space science subject such as textbook method, lecturer, demonstrations, study tours, problem-solving method, etc. Lectures method is the most commonly used of teaching earth and space science subject. The disadvantage of this method is the lack of two ways interaction between lecturers and students. This research used small group discussion as a teaching method in Earth and Space science. The purpose of this study is to identify the conditions under which an efficient discussion may be initiated and maintained while students are investigating properties of earth and space science subjects. The results of this research show that there is an increase in student’s understanding of earth and space science subject proven through the evaluation results. In addition, during the learning process, student’s activeness also increase.

Positive-definite functions and unitary representations of locally compact groups in a Hilbert space

International Nuclear Information System (INIS)

Gali, I.M.; Okb el-Bab, A.S.; Hassan, H.M.

1977-08-01

It is proved that the necessary and sufficient condition for the existence of an integral representation of a group of unitary operators in a Hilbert space is that it is positive-definite and continuous in some topology

Deep-level defects introduced by 1 MeV electron radiation in AlInGaP for multijunction space solar cells

International Nuclear Information System (INIS)

Lee, H.S.; Yamaguchi, M.; Ekins-Daukes, N. J.; Khan, A.; Takamoto, T.; Agui, T.; Kamimura, K.; Kaneiwa, M.; Imaizumi, M.; Ohshima, T.; Itoh, H.

2005-01-01

Presented in this paper are 1 MeV electron irradiation effects on wide-band-gap (1.97 eV) (Al 0.08 Ga 0.92 ) 0.52 In 0.48 P diodes and solar cells. The carrier removal rate estimated in p-AlInGaP with electron fluence is about 1 cm -1 , which is lower than that in InP and GaAs. From high-temperature deep-level transient spectroscopy measurements, a deep-level defect center such as majority-carrier (hole) trap H2 (E ν +0.90±0.05 eV) was observed. The changes in carrier concentrations (Δp) and trap densities as a function of electron fluence were compared, and as a result the total introduction rate, 0.39 cm -1 , of majority-carrier trap centers (H1 and H2) is different from the carrier removal rate, 1 cm -1 , in p-AlInGaP. From the minority-carrier injection annealing (100 mA/cm 2 ), the annealing activation energy of H2 defect is ΔE=0.60 eV, which is likely to be associated with a vacancy-phosphorus Frenkel pair (V p -P i ). The recovery of defect concentration and carrier concentration in the irradiated p-AlInGaP by injection relates that a deep-level defect H2 acts as a recombination center as well as compensator center

Characterization of the automorphisms having the lifting property in the category of abelian p-groups

Directory of Open Access Journals (Sweden)

H. Essannouni

2003-12-01

Full Text Available Let p be a prime. It is shown that an automorphism α of an abelian p-group A lifts to any abelian p-group of which A is a homomorphic image if and only if α=π idA, with π an invertible p-adic integer. It is also shown that if A is torsion group or torsion-free p-divisible group, then idA and −idA are the only automorphisms of A which possess the lifting property in the category of abelian groups.

Sphingosine-1-Phosphate Mediates ICAM-1-Dependent Monocyte Adhesion through p38 MAPK and p42/p44 MAPK-Dependent Akt Activation

Science.gov (United States)

Lin, Chih-Chung; Lee, I-Ta; Hsu, Chun-Hao; Hsu, Chih-Kai; Chi, Pei-Ling; Hsiao, Li-Der; Yang, Chuen-Mao

2015-01-01

Up-regulation of intercellular adhesion molecule-1 (ICAM-1) is frequently implicated in lung inflammation. Sphingosine-1-phosphate (S1P) has been shown to play a key role in inflammation via adhesion molecules induction, and then causes lung injury. However, the mechanisms underlying S1P-induced ICAM-1 expression in human pulmonary alveolar epithelial cells (HPAEpiCs) remain unclear. The effect of S1P on ICAM-1 expression was determined by Western blot and real-time PCR. The involvement of signaling pathways in these responses was investigated by using the selective pharmacological inhibitors and transfection with siRNAs. S1P markedly induced ICAM-1 expression and monocyte adhesion which were attenuated by pretreatment with the inhibitor of S1PR1 (W123), S1PR3 (CAY10444), c-Src (PP1), EGFR (AG1478), PDGFR (AG1296), MEK1/2 (U0126), p38 MAPK (SB202190), JNK1/2 (SP600125), PI3K (LY294002), or AP-1 (Tanshinone IIA) and transfection with siRNA of S1PR1, S1PR3, c-Src, EGFR, PDGFR, p38, p42, JNK1, c-Jun, or c-Fos. We observed that S1P-stimulated p42/p44 MAPK and p38 MAPK activation was mediated via a c-Src/EGFR and PDGFR-dependent pathway. S1P caused the c-Src/EGFR/PDGFR complex formation. On the other hand, we demonstrated that S1P induced p42/p44 MAPK and p38 MAPK-dependent Akt activation. In addition, S1P-stimulated JNK1/2 phosphorylation was attenuated by SP600125 or PP1. Finally, S1P enhanced c-Fos mRNA levels and c-Jun phosphorylation. S1P-induced c-Jun activation was reduced by PP1, AG1478, AG1296, U0126, SP600125, SB202190, or LY294002. These results demonstrated that S1P-induced ICAM-1 expression and monocyte adhesion were mediated through S1PR1/3/c-Src/EGFR, PDGFR/p38 MAPK, p42/p44 MAPK/Akt-dependent AP-1 activation. PMID:25734900

Dialogic spaces of knowledge construction in research article Conclusion sections written by English L1, English L2 and Spanish L1 writers

Directory of Open Access Journals (Sweden)

Elena Sheldon

2018-04-01

Full Text Available While vast research efforts have been directed to the identification of moves and their constituent steps in research articles (RA, less attention has been paid to the social negotiation of knowledge, in particular in the Conclusion section of RAs. In this paper, I examine the Conclusion sections of RAs in English and Spanish, including RA Conclusions written in English by Spanish-background speakers in the field of applied linguistics. This study brings together two complementary frameworks, genre-based knowledge and evaluative stance, drawing on Swales’s (1990, 2004 move analysis framework and on the engagement system in Martin and White’s (2005 Appraisal framework. The results indicate that the English L1 group negotiates a consistent space for readers to approve or disapprove the writers’ propositions. However, the Spanish L1 group aligns with readers, using a limited space through contracting resources, which may be because this group addresses a smaller audience in comparison to the English L1 group which addresses an international readership. On the other hand, the English L2 group tends to move towards English rhetorical international practice, but without fully abandoning their SpL1. These results contribute to gaining a better understanding of how successful scholarly writing in English is achieved, and offers important insights for teaching multilingual researchers.

26 CFR 1.1502-47 - Consolidated returns by life- nonlife groups.

Science.gov (United States)

2010-04-01

... company subject to taxation under section 831(a). For 1982, only P and L1 are eligible corporations. The... that the group's common parent shall exercise this election to discontinue (and the other members of...

Developing hybrid approaches to predict pKa values of ionizable groups

Science.gov (United States)

Witham, Shawn; Talley, Kemper; Wang, Lin; Zhang, Zhe; Sarkar, Subhra; Gao, Daquan; Yang, Wei

2011-01-01

Accurate predictions of pKa values of titratable groups require taking into account all relevant processes associated with the ionization/deionization. Frequently, however, the ionization does not involve significant structural changes and the dominating effects are purely electrostatic in origin allowing accurate predictions to be made based on the electrostatic energy difference between ionized and neutral forms alone using a static structure. On another hand, if the change of the charge state is accompanied by a structural reorganization of the target protein, then the relevant conformational changes have to be taken into account in the pKa calculations. Here we report a hybrid approach that first predicts the titratable groups, which ionization is expected to cause conformational changes, termed “problematic” residues, then applies a special protocol on them, while the rest of the pKa’s are predicted with rigid backbone approach as implemented in multi-conformation continuum electrostatics (MCCE) method. The backbone representative conformations for “problematic” groups are generated with either molecular dynamics simulations with charged and uncharged amino acid or with ab-initio local segment modeling. The corresponding ensembles are then used to calculate the pKa of the “problematic” residues and then the results are averaged. PMID:21744395

[Effects of hypoxia inducible factor-1α on P311 and its influence on the migration of murine epidermal stem cells].

Science.gov (United States)

Xu, Z D; Li, H S; Wang, S; He, W F; Wu, J; Luo, G X

2017-05-20

Objective: To explore the effects of hypoxia inducible factor-1α (HIF-1α) on P311 and its influence on the migration of murine epidermal stem cells (ESCs) under hypoxia in vitro. Methods: Two kinds of murine ESCs were isolated and obtained from 15 neonatal wild-type C57BL/6J mice and 5 congeneric source P311 gene knock-out mice, respectively. The first passage of cells were used in the following experiments after morphologic observation and detection of expression of cell surface markers CD71 and CD49f with flow cytometer. (1) After cell scratch assay, according to the random number table (the same dividing method below), ESCs of P311 gene knock-out mice were divided into normoxia group (cells were cultured with complete medium in normoxic carbon dioxide incubator, and the subsequent normoxic treatments were the same) and hypoxia group (cells were cultured in hypoxic carbon dioxide incubator containing 1% oxygen, and the subsequent hypoxic treatments were the same), with 12 inserts in each group. ESCs of wild-type mice were divided into normoxia group, pure hypoxia group, dimethyl sulfoxide (DMSO) control group (2 μL DMSO solvent was added for 1 h of normoxia treatment before hypoxia treatment), HIF-1α inhibitor group (cells were treated with 11 μmol/L HIF-1 inhibitor of 2 μL under normoxia condition for 1 h before hypoxia treatment), HIF-1α stabilizer group (the cells were treated with 2 μmol/L FG-4592 of 2 μL under normoxia condition for 1 h before hypoxia treatment), with 12 inserts in each group. Three inserts of each time point in each group were adopted respectively to measure the residual width of scratch under inverted phase contrast microscope at post scratch hour (PSH) 0 (immediately), 12, 24, and 48. (2) After hypoxia treatment, the protein level of HIF-1α in ESCs of wild-type mice was detected by Western blotting at post hypoxia hour (PHH) 0, 12, 24, and 48. (3) ESCs of wild-type mice were divided into pure hypoxia group, DMSO control group

Self-affine scaling from non-integer phase-space partition in $\\pi^{+}p$ and $K^{+}p$ collisions at 250 GeV/$c$

CERN Document Server

Agababian, N M

1998-01-01

A factorial-moment analysis with real (integer and non-integer) phase space partition is applied to $\\pi^+$p and K$^+$p collisions at 250 GeV/$c$. Clear evidence is shown for self-affine rather than self-similar power-law scaling in multiparticle production. The three-dimensional self-affine second-order scaling exponent is determined to be 0.061$\\pm$0.010.

Loop space representation of quantum general relativity and the group of loops

International Nuclear Information System (INIS)

Gambini, R.

1991-01-01

The action of the constraints of quantum general relativity on a general state in the loop representation is coded in terms of loop derivatives. These differential operators are related to the infinitesimal generators of the group of loops and generalize the area derivative first considered by Mandelstam. A new sector of solutions of the physical states space of nonperturbative quantum general relativity is found. (orig.)

Molecular characterization of pandemic H1N1 influenza viruses isolated from turkeys and pathogenicity of a human pH1N1 isolate in turkeys.

Science.gov (United States)

Berhane, Yohannes; Ojkic, Davor; Neufeld, James; Leith, Marsha; Hisanaga, Tamiko; Kehler, Helen; Ferencz, Arpad; Wojcinski, Helen; Cottam-Birt, Colleen; Suderman, Matthew; Handel, Katherine; Alexandersen, Soren; Pasick, John

2010-12-01

Suspected human-to-animal transmission of the 2009 pandemic H1N1 (pH1N1) virus has been reported in several animal species, including pigs, dogs, cats, ferrets, and turkeys. In this study we describe the genetic characterization of pH1N1 viruses isolated from breeder turkeys that was associated with a progressive drop in egg production. Sequence analysis of all eight gene segments from three viruses isolated from this outbreak demonstrated homology with other human and swine pH1N1 isolates. The susceptibility of turkeys to a human pH1N1 isolate was further evaluated experimentally. The 50% turkey infectious dose (TID50) for the human isolate A/Mexico/LnDRE/4487/2009 was determined by inoculating groups of 8-10-week-old turkeys with serial 10-fold dilutions of virus by oronasal and cloacal routes. We estimated the TID50 to be between 1 x 10(5) and 1 x 10(6) TCID50. The pathogenesis of pH1N1 in oronasally or cloacally inoculated juvenile turkeys was also examined. None of the turkeys exhibited clinical signs, and no significant difference in virus shedding or seroconversion was observed between the two inoculation groups. More than 50% of the turkeys in both oronasal and cloacal groups shed virus beginning at 2 days postinoculation (dpi). All birds that actively shed virus seroconverted by 14 dpi. Virus antigen was demonstrated by immunohistochemistry in the cecal tonsils and bursa of Fabricius in two of the birds that were infected by the cloacal route. Virus transmission to naive contact turkeys was at best doubtful. This report provides additional evidence that pH1N1 can cross the species barrier and cause disease outbreaks in domestic turkeys. However, it appears that the reproductive status of the host as well as environmental factors such as concurrent infections, stress, the presence or absence of litter, and stocking density may also contribute to efficient infection and transmission of this agent.

Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis.

Science.gov (United States)

Dai, Lan; Liu, Yixuan; Xie, Lei; Wu, Xia; Qiu, Lihua; Di, Wen

2017-09-26

Sphingosine kinase (SphK)/sphingosine-1-phosphate (S1P)/S1P receptor (S1PR) signaling pathway has been implicated in a variety of pathological processes of ovarian cancer. However, the function of this axis in ovarian cancer angiogenesis remains incompletely defined. Here we provided the first evidence that SphK1/S1P/S1PR 1/3 pathway played key roles in ovarian cancer angiogenesis. The expression level of SphK1, but not SphK2, was closely correlated with the microvascular density (MVD) of ovarian cancer tissue. In vitro , the angiogenic potential and angiogenic factor secretion of ovarian cancer cells could be attenuated by SphK1, but not SphK2, blockage and were restored by the addition of S1P. Moreover, in these cells, we found S1P stimulation induced the angiogenic factor secretion via S1PR 1 and S1PR 3 , but not S1PR 2 . Furthermore, inhibition of S1PR 1/3 , but not S1PR 2 , attenuated the angiogenic potential and angiogenic factor secretion of the cells. in vivo , blockage of SphK or S1PR 1/3 could attenuate ovarian cancer angiogenesis and inhibit angiogenic factor expression in mouse models. Collectively, the current study showed a novel role of SphK1/S1P/S1PR 1/3 axis within the ovarian cancer, suggesting a new target to block ovarian cancer angiogenesis.

Generalized 2-vector spaces and general linear 2-groups

OpenAIRE

Elgueta, Josep

2008-01-01

In this paper a notion of {\\it generalized 2-vector space} is introduced which includes Kapranov and Voevodsky 2-vector spaces. Various kinds of generalized 2-vector spaces are considered and examples are given. The existence of non free generalized 2-vector spaces and of generalized 2-vector spaces which are non Karoubian (hence, non abelian) categories is discussed, and it is shown how any generalized 2-vector space can be identified with a full subcategory of an (abelian) functor category ...

Distribution of the minimum path on percolation clusters: A renormalization group calculation

International Nuclear Information System (INIS)

Hipsh, Lior.

1993-06-01

This thesis uses the renormalization group for the research of the chemical distance or the minimal path on percolation clusters on a 2 dimensional square lattice. Our aims are to calculate analytically (iterative calculation) the fractal dimension of the minimal path. d min. , and the distributions of the minimum paths, l min for different lattice sizes and for different starting densities (including the threshold value p c ). For the distributions. We seek for an analytic form which describes them. The probability to get a minimum path for each linear size L is calculated by iterating the distribution of l min for the basic cell of size 2*2 to the next scale sizes, using the H cell renormalization group. For the threshold value of p and for values near to p c . We confirm a scaling in the form: P(l,L) =f1/l(l/(L d min ). L - the linear size, l - the minimum path. The distribution can be also represented in the Fourier space, so we will try to solve the renormalization group equations in this space. A numerical fitting is produced and compared to existing numerical results. In order to improve the agreement between the renormalization group and the numerical simulations, we also present attempts to generalize the renormalization group by adding more parameters, e.g. correlations between bonds in different directions or finite densities for occupation of bonds and sites. (author) 17 refs

Distributed Model Predictive Control over Multiple Groups of Vehicles in Highway Intelligent Space for Large Scale System

Directory of Open Access Journals (Sweden)

Tang Xiaofeng

2014-01-01

Full Text Available The paper presents the three time warning distances for solving the large scale system of multiple groups of vehicles safety driving characteristics towards highway tunnel environment based on distributed model prediction control approach. Generally speaking, the system includes two parts. First, multiple vehicles are divided into multiple groups. Meanwhile, the distributed model predictive control approach is proposed to calculate the information framework of each group. Each group of optimization performance considers the local optimization and the neighboring subgroup of optimization characteristics, which could ensure the global optimization performance. Second, the three time warning distances are studied based on the basic principles used for highway intelligent space (HIS and the information framework concept is proposed according to the multiple groups of vehicles. The math model is built to avoid the chain avoidance of vehicles. The results demonstrate that the proposed highway intelligent space method could effectively ensure driving safety of multiple groups of vehicles under the environment of fog, rain, or snow.

Planning and managing future space facility projects. [management by objectives and group dynamics

Science.gov (United States)

Sieber, J. E.; Wilhelm, J. A.; Tanner, T. A.; Helmreich, R. L.; Burgenbauch, S. F.

1979-01-01

To learn how ground-based personnel of a space project plan and organize their work and how such planning and organizing relate to work outcomes, longitudinal study of the management and execution of the Space Lab Mission Development Test 3 (SMD 3) was performed at NASA Ames Research Center. A view of the problems likely to arise in organizations and some methods of coping with these problems are presented as well as the conclusions and recommendations that pertain strictly to SMD 3 management. Emphasis is placed on the broader context of future space facility projects and additional problems that may be anticipated. A model of management that may be used to facilitate problem solving and communication - management by objectives (MBO) is presented. Some problems of communication and emotion management that MBO does not address directly are considered. Models for promoting mature, constructive and satisfying emotional relationships among group members are discussed.

Characterization, Leaching, and Filtration Testing for Bismuth Phosphate Sludge (Group 1) and Bismuth Phosphate Saltcake (Group 2) Actual Waste Sample Composites

International Nuclear Information System (INIS)

Lumetta, Gregg J.; Buck, Edgar C.; Daniel, Richard C.; Draper, Kathryn; Edwards, Matthew K.; Fiskum, Sandra K.; Hallen, Richard T.; Jagoda, Lynette K.; Jenson, Evan D.; Kozelisky, Anne E.; MacFarlan, Paul J.; Peterson, Reid A.; Shimskey, Rick W.; Sinkov, Sergey I.; Snow, Lanee A.

2009-01-01

A testing program evaluating actual tank waste was developed in response to Task 4 from the M-12 External Flowsheet Review Team (EFRT) issue response plan.() The test program was subdivided into logical increments. The bulk water-insoluble solid wastes that are anticipated to be delivered to the Waste Treatment and Immobilization Plant (WTP) were identified according to type such that the actual waste testing could be targeted to the relevant categories. Eight broad waste groupings were defined. Samples available from the 222S archive were identified and obtained for testing. The actual waste-testing program included homogenizing the samples by group, characterizing the solids and aqueous phases, and performing parametric leaching tests. Two of the eight defined groups - bismuth phosphate sludge (Group 1) and bismuth phosphate saltcake (Group 2) - are the subjects of this report. The Group 1 waste was anticipated to be high in phosphorus and was implicitly assumed to be present as BiPO4 (however, results presented here indicate that the phosphate in Group 1 is actually present as amorphous iron(III) phosphate). The Group 2 waste was also anticipated to be high in phosphorus, but because of the relatively low bismuth content and higher aluminum content, it was anticipated that the Group 2 waste would contain a mixture of gibbsite, sodium phosphate, and aluminum phosphate. Thus, the focus of the Group 1 testing was on determining the behavior of P removal during caustic leaching, and the focus of the Group 2 testing was on the removal of both P and Al. The waste-type definition, archived sample conditions, homogenization activities, characterization (physical, chemical, radioisotope, and crystal habit), and caustic leaching behavior as functions of time, temperature, and hydroxide concentration are discussed in this report. Testing was conducted according to TP-RPP-WTP-467

An interesting charmonium state formation and decay: p p-bar → 1 D2 → 1 P1γ

International Nuclear Information System (INIS)

Anselmino, M.; Caruso, F.; Universidade do Estado, Rio de Janeiro, RJ; Murgia, F.; Negrao, M.R.

1994-01-01

Massless perturbative QCD forbids, at leading order, the exclusive annihilation of proton-antiproton into some charmonium states, which however, have been observed in the pp channel, indicating the significance of higher order and non perturbative effects in the few GeV energy region. The most well known cases are those of the 1 S 0 (η c ) and the 1 P 1 . The case of the 1 D 2 is considered here and a way of detecting such a state through its typical angular distribution in the radiative decay 1 D 2 -> 1 D 2 -> 1 P 1 γ is suggested. Estimates of the branching ratio BR( 1 D 2 ->pp), as given by a quark-diquark model of the nucleon, mass corrections and an instanton induced process are presented. (author). 15 refs

Flow rate, pH and calcium concentration of saliva of children and adolescents with type 1 diabetes mellitus

Directory of Open Access Journals (Sweden)

A.R. Moreira

2009-08-01

Full Text Available Alterations in salivary parameters may increase the caries risk in diabetic children, but, contradictory data on this issue have been reported. The aims of this study were to compare salivary parameters (flow rate, pH and calcium concentration between healthy and type 1 diabetes mellitus (T1DM individuals. The sample consisted of 7- to 18-year-old individuals divided into two groups: 30 subjects with T1DM (group A and 30 healthy control subjects (group B. Fasting glucose levels were determined. Unstimulated and stimulated saliva was collected. The pH of unstimulated saliva was measured with paper strips and an electrode. Calcium concentrations in stimulated saliva were determined with a selective electrode. Group A individuals had inadequate blood glucose control (HbA1C >9%, with means ± SD unstimulated salivary flow rate of 0.15 ± 0.1 mL/min compared to 0.36 ± 0.2 mL/min for group B (P < 0.01. Stimulated salivary flow rate was similar by both groups and above 2.0 mL/min. Saliva pH was 6.0 ± 0.8 for group A and significantly different from 7.0 ± 0.6 for group B (P < 0.01. Salivary calcium was 14.7 ± 8.1 mg/L for group A and significantly higher than 9.9 ± 6.4 mg/L for group B (P < 0.01. Except for elevated calcium concentrations in saliva, salivary parameters favoring caries such as low saliva pH and unstimulated salivary flow rate were observed in T1DM individuals.

Dielectric relaxation and ionic conductivity studies of Na2ZnP2O7

Indian Academy of Sciences (India)

Administrator

compound crystallized in the tetragonal system with the space group P42/n and ... Philips PW 1710 diffractometer operating with copper radiation Kα = 1⋅5418 Å. .... between mobile ions and the environments surrounding them. The transport ...

Real Elements and p-Nilpotence of Finite Groups

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Adolfo Ballester-Bolinches

2016-12-01

Full Text Available Our first main result proves that every element of order 4 of a Sylow 2-subgroup S of a minimal non-2-nilpotent group G, is a real element of S. This allows to give a character-free proof of a theorem due to Isaacs and Navarro (see [9, Theorem B]. As an application, the authors show a common extension of the p-nilpotence criteria proved in [3] and [9].

The projectable hull of an archimedean $ell$-group with weak unit

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Anthony W. Hager

2017-07-01

Full Text Available The much-studied projectable hull of an $ell$-group $Gleq pG$ is an essential extension, so that, in the case that $G$ is  archimedean with weak unit, ``$Gin {bf W}$", we have for the Yosida representation spaces a ``covering map" $YG leftarrow YpG$. We have earlier cite{hkm2} shown that (1 this cover has a characteristic minimality property, and that (2 knowing $YpG$, one can write down $pG$. We now show directly that for $mathscr{A}$, the boolean algebra in the power set of the minimal prime spectrum $Min(G$, generated by the sets $U(g={Pin Min(G:gnotin P}$ ($gin G$, the Stone space $mathcal{A}mathscr{A}$ is a cover of $YG$ with the minimal property of (1; this extends the result from cite{bmmp} for the strong unit case. Then, applying (2 gives the pre-existing description of $pG$, which includes the strong unit description of cite{bmmp}. The present methods are largely topological, involving details of covering maps and Stone duality.

Expression, purification and preliminary X-ray crystallographic analysis of the chicken MHC class I molecule YF1*7.1

International Nuclear Information System (INIS)

Hee, Chee Seng; Gao, Song; Miller, Marcia M.; Goto, Ronald M.; Ziegler, Andreas; Daumke, Oliver; Uchanska-Ziegler, Barbara

2009-01-01

The chicken classical MHC class I antigen YF1*7.1 was crystallized together with β 2 -microglobulin but without a peptide ligand. Crystals diffracted synchrotron radiation to 1.32 Å and belonged to the monoclinic space group P2 1 . YF1*7.1 is an allele of a polymorphic major histocompatibility complex (MHC) class I-like locus within the chicken Y gene complex. With the aim of understanding the possible role of the YF1*7.1 molecule in antigen presentation, the complex of YF1*7.1 heavy chain and β 2 -microglobulin was reconstituted and purified without a peptide. Crystals diffracted synchrotron radiation to 1.32 Å resolution and belonged to the monoclinic space group P2 1 . The phase problem was solved by molecular replacement. A detailed examination of the structure may provide insight into the type of ligand that could be bound by the YF1*7.1 molecule