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Sample records for soomere riina prg

  1. Nord Stream on väljakutse kodanikuühiskonnale / Tarmo Soomere ; üles kirjutanud Juune Holvandus

    Index Scriptorium Estoniae

    Soomere, Tarmo, 1957-

    2009-01-01

    Gaasijuhe Nord Stream läbi Läänemere Venemaalt Saksamaale ei tähenda ainult kasulikku äritehingut. Küsimus on ennekõike ohutust keskkonnast ja sellest, et riigid peavad kaaluma ka seda, mida järeltulevad põlved asjast arvavad. Akadeemik Tarmo Soomere selgitab rahvusvahelistesse vetesse rajatava gaasijuhtme temaatikat.

  2. Õiglane maailm / Riina Luik

    Index Scriptorium Estoniae

    Luik, Riina, 1962-

    2008-01-01

    Õiglase kaubanduse toodete tarbimine maailmas kasvas 2007. aastal 47 %. Õiglase kaubanduse süsteemi sünniloost, arengust ja toodetest, Fairtrade'i kaupade tarbimisest ja kaubamärgi tuntusest Eestis. Arvamust avaldavad: Riina Kuusik, Mairika Juhandi, Anne Harak, Kätlin Rohilaid, Jaanus Vernik, Riina Pärnpuu, Ave Oit, Siret Shalamov. Lisad: Õiglane kaubandus maailmas; Käi õiges poes!; Eestis müüdavad Fairtrade'i tooted; The Body Shop

  3. EVALUASI KESEPADANAN MUTU GIZI TEMPE KEDELAI PANGAN REKAYASA GENETIK (PRG DAN NON-PRG SERTA DAMPAK KONSUMSINYA PADA TIKUS PERCOBAAN

    Directory of Open Access Journals (Sweden)

    Dadi Hidayat Maskar

    2016-04-01

    Full Text Available ABSTRACTThis study was conducted to evaluate the effect of tempe that were made from Genetically Modified (GM and non-GM soybean on protein quality, malondialdehide (MDA levels, intracellular antioxidant superoxide dismutase (SOD activity in the liver and kidneys, as well as spermatozoa profile of experimental rats. Fourty five Sprague Dawley rats divided into eight treatment grups and one control, fed with tempe and soybean from GM and non-GM at 10% and 20% concentrations for 90 days. The results showed that there was no significant difference in term of protein quality, tempe made from GM soybean is substantially equivalent with tempe made from non-GM soybean. Results showed that group which was given ration of 10% protein from conventional soybean had lower liver and kidney MDA levels as compared to GM tempe 10% and 20% groups, but was not significant compared to conventional soybean 20% and casein 10% groups. While the value of liver and kidney SOD activity were not significantly different (p>0.05 between the groups of rats. There was no significant differences among the spermatozoa profiles treatment groups and control and they were within normal condition. Results of protein quality, MDA, SOD, and spermatozoa profile showed that tempe made from GM soybean was substantially equivalent with the non-GM soybean.Keywords: GM soybean, MDA, non-GM tempe, SOD, spermatozoa profileABSTRAKTujuan penelitian ini adalah untuk mengevaluasi pengaruh tempe Pangan Rekayasa Genetik (PRG dan non-PRG meliputi kualitas protein, kadar malondialdehida (MDA hati dan ginjal, aktivitas superoksida dismutase (SOD hati dan ginjal, dan profil spermatozoa pada tikus percobaan. Sebanyak 45 tikus terbagi ke dalam delapan perlakuan dan satu kontrol yang diberikan perlakuan dengan ransum tempe dan kedelai, baik PRG maupun non-PRG, dengan konsentrasi 10% dan 20% selama 90 hari. Hasil percobaan menunjukkan bahwa tidak ada perbedaan yang signifikan dalam kualitas protein

  4. Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice

    Directory of Open Access Journals (Sweden)

    Kimberly A. Waller

    2017-06-01

    Full Text Available Deficiency of PRG4 (lubricin, the boundary lubricant in mammalian joints, contributes to increased joint friction accompanied by superficial and upper intermediate zone chondrocyte caspase-3 activation, as shown in lubricin-null (Prg4−/− mice. Caspase-3 activity appears to be reversible upon the restitution of Prg4 either endogenously in vivo, in a gene trap mouse, or as an applied lubricant in vitro. In this study we show that intra-articular injection of human PRG4 in vivo in Prg4−/− mice prevented caspase-3 activation in superficial zone chondrocytes and was associated with a modest decrease in whole joint friction measured ex vivo using a joint pendulum method. Non-lubricated Prg4−/− mouse cartilage shows caspase cascade activation caused by mitochondrial dysregulation, and significantly higher levels of peroxynitrite (ONOO− and −OH and superoxide (O−2 compared to Prg4+/+ and Prg4+/− cartilage. Enzymatic activity levels of caspase 8 across Prg4 mutant mice were not significantly different, indicating no extrinsic apoptosis pathway activation. Western blots showed caspase-3 and 9 activation in Prg4−/− tissue extracts, and the appearance of nitrosylated Cys163 in the active cleft of caspase-3 which inhibits its enzymatic activity. These findings are relevant to patients at risk for arthrosis, from camptodactyl-arthropathy-coxa vara-pericarditis (CACP syndrome and transient lubricin insufficiency due to trauma and inflammation.

  5. ABRF-PRG07: advanced quantitative proteomics study.

    Science.gov (United States)

    Falick, Arnold M; Lane, William S; Lilley, Kathryn S; MacCoss, Michael J; Phinney, Brett S; Sherman, Nicholas E; Weintraub, Susan T; Witkowska, H Ewa; Yates, Nathan A

    2011-04-01

    A major challenge for core facilities is determining quantitative protein differences across complex biological samples. Although there are numerous techniques in the literature for relative and absolute protein quantification, the majority is nonroutine and can be challenging to carry out effectively. There are few studies comparing these technologies in terms of their reproducibility, accuracy, and precision, and no studies to date deal with performance across multiple laboratories with varied levels of expertise. Here, we describe an Association of Biomolecular Resource Facilities (ABRF) Proteomics Research Group (PRG) study based on samples composed of a complex protein mixture into which 12 known proteins were added at varying but defined ratios. All of the proteins were present at the same concentration in each of three tubes that were provided. The primary goal of this study was to allow each laboratory to evaluate its capabilities and approaches with regard to: detection and identification of proteins spiked into samples that also contain complex mixtures of background proteins and determination of relative quantities of the spiked proteins. The results returned by 43 participants were compiled by the PRG, which also collected information about the strategies used to assess overall performance and as an aid to development of optimized protocols for the methodologies used. The most accurate results were generally reported by the most experienced laboratories. Among laboratories that used the same technique, values that were closer to the expected ratio were obtained by more experienced groups.

  6. Comparison of fluoroscopy-guided pull-type percutaneous radiological gastrostomy (pull-type-PRG) with conventional percutaneous radiological gastrostomy (push-type-PRG): clinical results in 253 patients

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Yang; Schneider, J.; Dueber, C.; Pitton, M.B. [University Medical Center of the Johannes Gutenberg University Mainz, Department of Diagnostic and Interventional Radiology, Mainz (Germany)

    2011-11-15

    To analyze the clinical results and complications of fluoroscopy guided internal-external pull-type percutaneous radiological gastrostomy (pull-type-PRG) and conventional external-internal percutaneous radiological gastrostomy (push-type-PRG). A total of 253 patients underwent radiological gastrostomy between January 2002 and January 2010. Data were collected retrospectively from radiology reports, Chart review of clinical notes, procedure reports, discharge summaries and subsequent hospital visits. Statistical analysis was performed to compare the two methods for gastrostomy with respect to peri-interventional aspects and clinical results. 128 patients received the Pull-type-PRG whereas the other 125 patients were served with the Push-type-PRG. Indications for gastrostomy were similar in these two groups. The most frequent indications for the both methods were stenotic oesophageal tumors or head/neck tumors (54.7% in pull-type-PRG, 68% in push-type-PRG). Gastrostomy procedures were successful in 98.3% in pull-type-PRG compared to 92% in push-type-PRG. There was no procedure-related mortality. Compared to Push-type-PRG, the peri-interventional complication rate was significantly reduced in pull-type-PRG (14.8% versus 34.4%, P = 0.002). Compared to the external-internal push-type-PRG, the internal-external Pull-type-PRG showed a high primary success rate and a decreased incidence of peri-interventional complications. (orig.)

  7. Comparison of fluoroscopy-guided pull-type percutaneous radiological gastrostomy (pull-type-PRG) with conventional percutaneous radiological gastrostomy (push-type-PRG): clinical results in 253 patients

    International Nuclear Information System (INIS)

    Yang, Yang; Schneider, J.; Dueber, C.; Pitton, M.B.

    2011-01-01

    To analyze the clinical results and complications of fluoroscopy guided internal-external pull-type percutaneous radiological gastrostomy (pull-type-PRG) and conventional external-internal percutaneous radiological gastrostomy (push-type-PRG). A total of 253 patients underwent radiological gastrostomy between January 2002 and January 2010. Data were collected retrospectively from radiology reports, Chart review of clinical notes, procedure reports, discharge summaries and subsequent hospital visits. Statistical analysis was performed to compare the two methods for gastrostomy with respect to peri-interventional aspects and clinical results. 128 patients received the Pull-type-PRG whereas the other 125 patients were served with the Push-type-PRG. Indications for gastrostomy were similar in these two groups. The most frequent indications for the both methods were stenotic oesophageal tumors or head/neck tumors (54.7% in pull-type-PRG, 68% in push-type-PRG). Gastrostomy procedures were successful in 98.3% in pull-type-PRG compared to 92% in push-type-PRG. There was no procedure-related mortality. Compared to Push-type-PRG, the peri-interventional complication rate was significantly reduced in pull-type-PRG (14.8% versus 34.4%, P = 0.002). Compared to the external-internal push-type-PRG, the internal-external Pull-type-PRG showed a high primary success rate and a decreased incidence of peri-interventional complications. (orig.)

  8. Kaubamaja Naistemaailm = Tallinn Kaubamaja Ladies' World / Külli Salum, Riina Harik

    Index Scriptorium Estoniae

    Salum, Külli, 1971-

    2013-01-01

    Tallinna Kaubamaja Naistemaailma (Gonsiori 2) sisekujundusest. Autorid: Külli Salum ja Riina Harik (Saha IN). Skulptuurid: Kalle-Priit Pruuden. Sisearhitekti ja ESLi aastapreemiate žürii liikme Tarmo Piirmetsa arvamus

  9. Missugused on teie kogemused väikeklassidega? / Villu Mengel, Ana Kontor, Katrin Betlem, Riina Kink

    Index Scriptorium Estoniae

    2013-01-01

    Küsimusele vastasid Sikupilli keskkooli direktor Villu Mengel, Tartu hariduse tugiteenuste keskuse eripedagoog Ana Kontor, Tabasalu ühisgümnaasiumi õppejuht-sotsiaalpedagoog Katrin Betlem, Keila kooli põhikooli õppejuht Riina Kink

  10. Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.

    Science.gov (United States)

    Schneider, Patrick; Petzold, Sandra; Sommer, Angela; Nitsch, Robert; Schwegler, Herbert; Vogt, Johannes; Roskoden, Thomas

    2018-01-15

    Plasticity related gene 1 (PRG-1) is a neuron specific membrane protein located at the postsynaptic density of glutamatergic synapses. PRG-1 modulates signaling pathways of phosphorylated lipid substrates such as lysophosphatidic acid (LPA). Deletion of PRG-1 increases presynaptic glutamate release probability leading to neuronal over-excitation. However, due to its cortical expression, PRG-1 deficiency leading to increased glutamatergic transmission is supposed to also affect motor pathways. We therefore analyzed the effects of PRG-1 function on exploratory and motor behavior using homozygous PRG-1 knockout (PRG-1 -/- ) mice and PRG-1/LPA 2 -receptor double knockout (PRG-1 -/- /LPA 2 -/- ) mice in two open field settings of different size and assessing motor behavior in the Rota Rod test. PRG-1 -/- mice displayed significantly longer path lengths and higher running speed in both open field conditions. In addition, PRG-1 -/- mice spent significantly longer time in the larger open field and displayed rearing and self-grooming behavior. Furthermore PRG-1 -/- mice displayed stereotypical behavior resembling phenotypes of psychiatric disorders in the smaller sized open field arena. Altogether, this behavior is similar to the stereotypical behavior observed in animal models for psychiatric disease of autistic spectrum disorders which reflects a disrupted balance between glutamatergic and GABAergic synapses. These differences indicate an altered excitation/inhibition balance in neuronal circuits in PRG-1 -/- mice as recently shown in the somatosensory cortex [38]. In contrast, PRG-1 -/- /LPA 2 -/- did not show significant changes in behavior in the open field suggesting that these specific alterations were abolished when the LPA 2 -receptor was lacking. Our findings indicate that PRG-1 deficiency led to over-excitability caused by an altered LPA/LPA 2 -R signaling inducing a behavioral phenotype typically observed in animal models for psychiatric disorders. Copyright

  11. Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling

    DEFF Research Database (Denmark)

    Cheng, Jin; Sahani, Sadhna; Hausrat, Torben Johann

    2016-01-01

    Precise connection of thalamic barreloids with their corresponding cortical barrels is critical for processing of vibrissal sensory information. Here, we show that PRG-2, a phospholipid-interacting molecule, is important for thalamocortical axon guidance. Developing thalamocortical fibers both...

  12. Verification of EPA's " Preliminary remediation goals for radionuclides" (PRG) electronic calculator

    Energy Technology Data Exchange (ETDEWEB)

    Stagich, B. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-03-29

    The U.S. Environmental Protection Agency (EPA) requested an external, independent verification study of their “Preliminary Remediation Goals for Radionuclides” (PRG) electronic calculator. The calculator provides information on establishing PRGs for radionuclides at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites with radioactive contamination (Verification Study Charge, Background). These risk-based PRGs set concentration limits using carcinogenic toxicity values under specific exposure conditions (PRG User’s Guide, Section 1). The purpose of this verification study is to ascertain that the computer codes has no inherit numerical problems with obtaining solutions as well as to ensure that the equations are programmed correctly.

  13. RESRAD for Radiological Risk Assessment. Comparison with EPA CERCLA Tools - PRG and DCC Calculators

    Energy Technology Data Exchange (ETDEWEB)

    Yu, C. [Argonne National Lab. (ANL), Argonne, IL (United States); Cheng, J. -J. [Argonne National Lab. (ANL), Argonne, IL (United States); Kamboj, S. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-07-01

    The purpose of this report is two-fold. First, the risk assessment methodology for both RESRAD and the EPA’s tools is reviewed. This includes a review of the EPA’s justification for 2 using a dose-to-risk conversion factor to reduce the dose-based protective ARAR from 15 to 12 mrem/yr. Second, the models and parameters used in RESRAD and the EPA PRG and DCC Calculators are compared in detail, and the results are summarized and discussed. Although there are suites of software tools in the RESRAD family of codes and the EPA Calculators, the scope of this report is limited to the RESRAD (onsite) code for soil contamination and the EPA’s PRG and DCC Calculators also for soil contamination.

  14. Automatic classification of canine PRG neuronal discharge patterns using K-means clustering.

    Science.gov (United States)

    Zuperku, Edward J; Prkic, Ivana; Stucke, Astrid G; Miller, Justin R; Hopp, Francis A; Stuth, Eckehard A

    2015-02-01

    Respiratory-related neurons in the parabrachial-Kölliker-Fuse (PB-KF) region of the pons play a key role in the control of breathing. The neuronal activities of these pontine respiratory group (PRG) neurons exhibit a variety of inspiratory (I), expiratory (E), phase spanning and non-respiratory related (NRM) discharge patterns. Due to the variety of patterns, it can be difficult to classify them into distinct subgroups according to their discharge contours. This report presents a method that automatically classifies neurons according to their discharge patterns and derives an average subgroup contour of each class. It is based on the K-means clustering technique and it is implemented via SigmaPlot User-Defined transform scripts. The discharge patterns of 135 canine PRG neurons were classified into seven distinct subgroups. Additional methods for choosing the optimal number of clusters are described. Analysis of the results suggests that the K-means clustering method offers a robust objective means of both automatically categorizing neuron patterns and establishing the underlying archetypical contours of subtypes based on the discharge patterns of group of neurons. Published by Elsevier B.V.

  15. Director läks ja küsis / Reet Neemoja, Jaanika Kuusik, Riina Varts... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    MicroLinki personalijuht Reet Neemoja, Elioni personalijuht Jaanika Kuusik, Eesti Energia personalijuht Riina Varts, Rimi personalijuht Õrne Lainde ning Sampo panga personalijuht Liina Oks vastavad küsimustele, mis puudutavad nende suurimat tööalast õppetundi 2009. aastal ning kõige olulisemat 2010. aastal

  16. Verification of EPA's ''Preliminary Remediation Goals for radionuclides'' (PRG) electronic calculator

    Energy Technology Data Exchange (ETDEWEB)

    Jannik, Tim [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Stagich, Brooke [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-08-28

    The U.S. Environmental Protection Agency (EPA) requested an external, independent verification study of their updated “Preliminary Remediation Goals for Radionuclides” (PRG) electronic calculator. The calculator provides PRGs for radionuclides that are used as a screening tool at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and Resource Conservation and Recovery Act (RCRA) sites. These risk-based PRGs establish concentration limits under specific exposure scenarios. The purpose of this verification study is to determine that the calculator has no inherit numerical problems with obtaining solutions as well as to ensure that the equations are programmed correctly. There are 167 equations used in the calculator. To verify the calculator, all equations for each of seven receptor types (resident, construction worker, outdoor and indoor worker, recreator, farmer, and composite worker) were hand calculated using the default parameters. The same four radionuclides (Am-241, Co-60, H-3, and Pu-238) were used for each calculation for consistency throughout.

  17. InvS Coordinates Expression of PrgH and FimZ and Is Required for Invasion of Epithelial Cells by Salmonella enterica serovar Typhimurium

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Lu; Cai, Xia; Wu, Shuyan; Bomjan, Rajdeep; Nakayasu, Ernesto S.; Händler, Kristian; Hinton, Jay C. D.; Zhou, Daoguo; DiRita, Victor J.

    2017-04-24

    ABSTRACT

    Deep sequencing has revolutionized our understanding of the bacterial RNA world and has facilitated the identification of 280 small RNAs (sRNAs) inSalmonella. Despite the suspicions that sRNAs may play important roles inSalmonellapathogenesis, the functions of most sRNAs remain unknown. To advance our understanding of RNA biology inSalmonellavirulence, we searched for sRNAs required for bacterial invasion into nonphagocytic cells. After screening 75 sRNAs, we discovered that the ablation of InvS caused a significant decrease ofSalmonellainvasion into epithelial cells. A proteomic analysis showed that InvS modulated the levels of several type III secretedSalmonellaproteins. The level of PrgH, a type III secretion apparatus protein, was significantly lower in the absence of InvS, consistent with the known roles of PrgH in effector secretion and bacterial invasion. We discovered that InvS modulatesfimZexpression and hence flagellar gene expression and motility. We propose that InvS coordinates the increase of PrgH and decrease in FimZ that promote efficientSalmonellainvasion into nonphagocytic cells.

    IMPORTANCESalmonellosis continues to be the most common foodborne infection reported by the CDC in the United States. Central toSalmonellapathogenesis is the ability to invade nonphagocytic cells and to replicate inside host cells. Invasion genes are known to be regulated by protein transcriptional networks, but little is known

  18. Pottseppade Portugal / Riina Robinson

    Index Scriptorium Estoniae

    Robinson, Riina

    2006-01-01

    Portugali ühest populaarsemast käsitööliigist - keraamikast ja selle huvitavatest variantidest ning regiooniti iseloomulikest erinevustest - maalingute värvidest, mustritest, tehnoloogiast nii nõudel kui ka keraamilistel plaatidel

  19. Hingedekuu menufilmid / Riina Sildos

    Index Scriptorium Estoniae

    Sildos, Riina

    1999-01-01

    Romantiline komöödia "Põgenev pruut" : režissöör Garry Marshall : Ameerika Ühendriigid 1999 ja komöödia "Austin Powers : Spioon, kes kargas mind" : režissöör Jay Roach : Ameerika Ühendriigid 1999

  20. Valge mehe koorem / Riina Kaljurand

    Index Scriptorium Estoniae

    Kaljurand, Riina, 1975-

    2007-01-01

    Maailmapanga majandusanalüütiku arenguriikide abiprogrammide ja arenguabi poliitika analüüs William Easterly raamatus The White Man's Burden: Why the West's Efforts to Aid the Rest Have Done So Much Ill and So Little Good. - Penguin Press, 2006

  1. Edinburghi festival kui kogemus / Riina Oruaas

    Index Scriptorium Estoniae

    Oruaas, Riina

    2008-01-01

    Edinburghis toimuvast rahvusvahelisest teatri- ehk etenduskunstide festivalist Fringe 2008 (8. - 31. VIII 2008). Pikemalt mõningatest tantsu- ja sõnalavastusest ning teatrikriitikute tööst seoses festivaliga

  2. Kuressaarest kaks laureaaditiitlit / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2008-01-01

    Maakondlikust etlejate konkursist. Žüriisse kuulusid Maret Oomer, Asta Leiten ja Kalle Piiskoppel. 5.-7. klasside arvestuses I koht: Marleen Petersell. Äramärkimist leidsid: Kristian Käresk, Maarja-Liis Mölder ja Anita Tuula. 7.-9. klasside arvestuses I koht: Oliver Taul. Esile tõsteti: Rauno Reinas, Riko Osila, Linda Maisväli ja Piia Puuraid. 10.-12. klasside arvestuses I koht: Karl Sakrits. Ära märgiti: Elin Küti, Virgo Ernits, Maria Orb. Kommenteerisid Asta Leiten, Liann Saage-Vahur. Ka Kuressaares toimunud vabariiklikust etlejate konkursist, kommentaare jagasid Merle Rekaya, Rita Ilves. Zhürisse kuulusid Aare Toikka, Tiina Rebane, Hans Kaldoja, Kristiina Omer ja Keete Viira. Peapreemia nooremas vanuseastmes Markkus Pulgale, keskmises vanuseastmes Anna Talvile ja vanemas vanuseastmes Doris Täkkerile.

  3. Naiskodukaitse aastatel 1925-1940 / Riina Nemvalts

    Index Scriptorium Estoniae

    Nemvalts, Riina

    2003-01-01

    Järg 17. mai, lk. 16 ; 20. mai, lk. 6 ; 24. mai, lk. 16 ; 31. mai, lk. 12 ; 5. juuni, lk. 10 ; 14. juuni, lk. 16 ; 19. juuni, lk. 10 ; 21. juuni, lk. 16 ; 26. juuni, lk. 6 ; 28. juuni, lk. 18 ; 1. juuli, lk. 10 ; 3. juulil, lk. 10 ; 5. juuli, lk.16

  4. Punane Veski ja plakatikunsti algus / Riina Robinson

    Index Scriptorium Estoniae

    Robinson, Riina

    2007-01-01

    Prantsuse plakatikunsti loojast Jules Cheret'st, ühest silmapaistvamast plakati- ja maalikunstnikust Henri Toulouse-Lautrecist, tema plakatite kangelannadest, kankaani tantsinud Louise Weberist ja Jane Avrilist ning Moulin Rouge'ist

  5. Picasso kõrge hind / Riina Robinson

    Index Scriptorium Estoniae

    Robinson, Riina

    2007-01-01

    Pablo Picassost, tema loomingust, 2003.a Malagas Picasso muuseumi ja kunstniku sünnikodu avamisest, maailma kallemailt müüdud maalide TOP 10-sse kuuluvatest maalidest "Poiss piibuga" (1905) ja "Dora Maar kassiga" (1941), hindadest. Maailma kalleimad oksjonil müüdud maalid: I - Jackson Pollocki "Nr.5, 1948" (hind:140 miljonit dollarit), II - William De Kooningi "Woman III" (1952-53), III - Gustav Klimti "Adele Bloch-Bauer I portree" (1907)

  6. Pärlid juveelide kuningannad / Riina Robinson

    Index Scriptorium Estoniae

    Robinson, Riina

    2008-01-01

    Pärlite erinevatest kasutusviisidest. Pärlite kandmise ajaloost. Kuulsad pärlid: Pearl of Allah, La Peregrina, La Pellegrina, La Perle Napoleon. Kunstpärlite tootmisest. Pärlite kasvatamisest Jaapanis

  7. 20 miljonit keskkonnaprojektidele / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2006-01-01

    Jõgevamaa keskkonnaprojektid said Keskkonnainvesteeringute Keskuselt (KIK) toetust. Suuremad toetusesaajad olid Põltsamaa vallavalitsuse piirkondliku jäätmejaama projekt, Mustvee linnavalitsuse ja Puurmani vallavalitsuse veekaitseprojektid

  8. From yesterday till tomorrow / Riina Reinvelt

    Index Scriptorium Estoniae

    Reinvelt, Riina

    2005-01-01

    Eesti Rahva Muuseumi peamised kogumissuunad 2000-te algul: argielu strateegiad Nõukogude Eestis, eestivenelaste ja vanausuliste subkultuurid Ida-Virumaal ja Peipsi järve piirkonnas, traditsioonilised töövõtted internetis, Karula Rahvuspargi pärandkultuur

  9. Kassinurme saab Kassirabaks / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2006-01-01

    30. juulil esietendub Jõgeva Linna Teatri vabaõhulavastus "Kassirabal", milles teevad kaasa ka professionaalsed näitlejad Ülle Lichtfeldt, Ines Aru ja Luule Komissarov ning Jõgeva, Põltsamaa, Tallinna, Mäetaguse ja teiste paikade harrastusnäitlejad

  10. Edasi loodusesse! Aga kuhu? / Riina Oruaas

    Index Scriptorium Estoniae

    Oruaas, Riina

    2007-01-01

    Tantsulavastustest: Oksana Titova, Päär Pärenson ja Juhan Ulfsak "Roots", Kaja Kanni sooloetendus "There are Laika dogs living in Estonia", Tiina Mölder, Kaja Kann ja Bush Hartshor "Naine ja Hunt"

  11. Eridiplom õppefilmi eest / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2007-01-01

    Eesti 42. amatöörfilmide festivalil Tallinna Kinomajas tunnistati parimaks õppefilmiks põltsamaalase Väino Valdmanni "Valli Lember-Bogatkina meistriklass". Kolm auhinda (seejuures parima täiskasvanud autorifilm) sai"Elevanti nägema" (autorid S. Dürdoth, M. Apel, L. Shamis, K. Saar) Ka teistest auhinnasaajatest

  12. Moemärke Hispaaniast / Riina Robinson

    Index Scriptorium Estoniae

    Robinson, Riina

    2008-01-01

    Kuulsad Hispaania moekunstnikud Paco Rabanne (sünd. 1934), Cristobal Balenciaga, Agatha Ruiz de la Prada (sünd. 1960), Oscar de la Renta (1932), Paloma Picasso (1949). Rõivapoodide ketid Zara, Mango ja El Corte Ingles

  13. VALUTAZIONI INTERSCALARI NEL PROCESSO PEREQUATIVO DEL PRG DI SIRACUSA

    Directory of Open Access Journals (Sweden)

    Salvatore Giuffrida

    2017-06-01

    Full Text Available The implementation process of the Syracuse’s Master Plan is characterized by the widespread use of “urban negotiation”. The Muni- cipality has drawn up a protocol aimed at obtaining areas for facilities and public infrastructures in different areas basing on the rule of the transfer of a portion of land in return for the building permission for the remaining part. Since these areas are variously cha- racterized, the negotiation process may not be fair to Municipality or convenient to land owners. Basing on an equalization pattern, this study provides, for each area, the indexes of fairness and convenience, and, more specifically, the difference between the market value of the areas achieved and the value of the permits issued. And based on the possibility to transfer the development rights, some different scenarios are prefigured about the possibility of acquiring additional areas for social housing and/or achieving funds for su- stainable buildings.

  14. Suurem, pikem, lõikamata / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2000-01-01

    Animafilm "South Park : suurem, pikem ja lõikamata" ("South Park . Bigger, Longer & Uncut") : Stsenaristid Trey Parker, Matt Stone ja Pam Brady : režissöör Trey Parker : Ameerika Ühendriigid 1999

  15. Troopiline paradiis otse Euroopa südames / Riina Luik

    Index Scriptorium Estoniae

    Luik, Riina, 1962-

    2010-01-01

    Berliini-Dresdeni kiirtee ääres asuvast troopilisest veekeskusest Tropical Islands, mis pakub siseruumis rannapuhkust ja rõõmustab puhkajat ookeani, vihmametsa, kämpinguala, kohvikute, jõusaali, saunade, erinevate meelelahutusetendustega jne

  16. Mis on õiglane kaubandus? / Riina Kuusik ; interv. Inge Pitsner

    Index Scriptorium Estoniae

    Kuusik, Riina

    2006-01-01

    ETV saate "Tasakaal" tegijad külastasid Nicaraguat ja Costa Ricat, et vaadata, kuidas elavad ja töötavad "õiglase kaubanduse" süsteemi kuuluvad talunikud, õiglase kaubanduse (fairtrade) mõistest

  17. Rootslanna Eestis kirjutas uue rootsi keele õpiku / Riina Noodapera

    Index Scriptorium Estoniae

    Noodapera, Riina, 1952-

    2007-01-01

    Carina Adolfssoni elust ja töötamisest Eestis. Rets. rmt.: Adolfsson, Carina. Sverige på svenska : lärobok i svenska för nybörjare : rootsi keele õpik algajatele : textbook in Swedish for beginners. Tallinn : Infotrükk, 2007. 179 lk.

  18. Lenz, Eestis unustatud geenius / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2001-01-01

    Tartus toimunud rahvusvahelise Lenzi-konverentsi (Jakob Michael Reinhold Lenz) publik nägi väljasõidul Põltsamaale Lenzi kirjutatud näidendit "Haavatud peigmees", mis esitati Tartu üliõpilasteatri poolt Põltsamaa lossihoovis. Lav. Kalev Kudu

  19. Nukkude salapärane maailm / Riina Robinson

    Index Scriptorium Estoniae

    Robinson, Riina

    2007-01-01

    Nukkudest, nende ajaloost, valmistamisviisidest ja materjalidest, kasutamise eesmärkidest, matrjoshkadest, barbie'st, seksikatest Bratz-nukkudest ja nende mõjust laste psüühhikale, nukust kui moe propageerijast ning nukumööblist

  20. OÜ Same sai tootearendustoetust / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2008-01-01

    Tabiveres põllu- ja teehooldusmasinaid tootev OÜ Same sai Ettevõtluse Arendamise Sihtasutuse kaudu üle poole miljoni krooni tootearendustoetust, mille abil töötab firma välja uue, senisest paindlikuma ja multifunktsionaalsema ketas-liivapuisturi

  1. Prantsusmaa silub Ida-Euroopga suhteid / Riina Luik

    Index Scriptorium Estoniae

    Luik, Riina, 1962-

    2004-01-01

    Prantsusmaa peaminister Jean-Pierre Raffarin kohtus Pariisis Ida-Euroopa ajakirjanikega ja rääkis EL-i riikide suhetest ja majanduskoostööst. Vt. samas: Andres Kasekamp. Näpuga viibutamise aeg on möödas. Lisa: Jean-Pierre Raffarin (55)

  2. Teatriekspressiga Äksist Põltsamaale / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2007-01-01

    Jõgevamaa harrastus- ja projektitruppide vabaõhulavastuste esietendustest 2006. aastal : Priit Aimla "Saadjärve saamise lugu" (Tabivere Harrastusteater, lavastaja Tõnis Lepp), Oskar Lutsu loomingust inspireeritud Veiko Märka "Sabani sõlmes Luts" (Palamuse Amatöörteater, lavastaja Raivo Adlas), Marina Carri "Kassirabal" projektitrupi esituses, lavastaja Ain Saviauk, Mati Tiku "Legend" (Saare Valla Metsateater, lavastaja autor), Ain Saviaugu "Ulm ehk Unistus Liivimaast" (Põltsamaa teater Ellunäod, lavastaja autor)

  3. Kõik on kusagil olemas / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2005-01-01

    Deivi Oru (34) maalinäitusest "Sentimentaalsed maastikud" Põltsamaa kultuurikeskuse galeriis. Kunstniku elukäigust ja loomingust Eestis ja Hispaanias: kampsunite kudumisest maalikunstini. Hispaanias kasutab ta nime Monica del Norte

  4. Kes kunstnik on selle pildi teinud ? / Riina Noodapera

    Index Scriptorium Estoniae

    Noodapera, Riina, 1952-

    2011-01-01

    Autor selgitab Eesti paadipõgenike foto ajalugu. Samas lisatud ka foto, millel kujutatud Lennart Meri, Christina Anderson, Helle Meri, Ellen Holmert ja Thorsten Andersson. Foto on tehtud 1995. a. seoses Lennart Meri külaskäiguga Gotlandile 1995. a.

  5. Majanduslikult soodsaim pakkumus ja pakkumuste hindamise kriteeriumid / Riina Karro

    Index Scriptorium Estoniae

    Karro, Riina

    2011-01-01

    Majanduslikult soodsaima pakkumuse ja madalaima hinnaga pakkumuse vahest ning majanduslikult soodsaima pakkumuse kui hindamiskriteeriumi sisunõuetest. Kvalifikatsiooni puudutavate tingimuste kasutamisest hindamiskriteeriumina

  6. Riina Vändre is the best P.R. manager in Estonia / Riina Vändre

    Index Scriptorium Estoniae

    Vändre, Riina, 1972-

    2004-01-01

    Turu-uuringute AS-i poolt ajakirjanike hulgas läbi viidud küsitluse tulemusel Eesti parimaks suhtekorraldajaks valitud Eesti Energia avalike suhete juht oma tööst monopoolse suurettevõtte maine kujundamisel

  7. [The development and validation of two scales on retribution practices: PRG-13 and PRE-21].

    Science.gov (United States)

    Boada-Grau, Joan; Costa-Solé, Jordi; Gil-Ripoll, Carme; Vigil-Colet, Andreu

    2012-01-01

    The present study outlines the development process of two scales that measure general and specific retribution practices in organisations. Historically, retribution has been the subject of research of other social sciences such as Sociology and Business Administration. In Psychology, and more specifically in Work and Organisational Psychology, there are hardly any studies or inventories designed to evaluate retribution practices. In order to accomplish the objectives, a sample of 237 employees was selected, 42.6% of whom were women and 57.4% were men. We performed and exploratory factorial analysis using principal axis factoring as extraction method and an oblique rotation (oblimin) to analyse the two scales. The former is made up of four factors and the latter is a two-factor scale. The reliability coefficients of the six subscales we obtained ranged between .72 and .89. External validity was analysed using the correlations obtained between the two inventories and the Balanced Scorecard. The two tools were found to be two potentially useful scales to evaluate retribution practices.

  8. Direktiivsed aktipaarid eestikeelsetes infodialoogides ja nende automaatne tuvastamine / Olga Gerassimenko, Riina Kasterpalu, Mare Koit ... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Analüüsitakse ametiasutustesse tulnud telefonikõnesid, eesmärgiga arendada intelligentset kasutajaliidest, mis võimaldaks suhelda andmebaasiga eesti keeles. Täpsemalt keskendutakse dialoogiakti direktiivsetele naabruspaaridele

  9. Väliskaubandus, jaanuar-oktoober 2008 = Foreign trade, January-October 2008 / Riina Kerner

    Index Scriptorium Estoniae

    Kerner, Riina

    2008-01-01

    Eesti väliskaubanduse näitajatest 2008. aasta jaanuarist kuni oktoobrini: Eesti kaupade eksport oli 113,1 miljardit krooni, import 145,2 miljardit krooni, kaubavahetuse puudujääk oli 32,1 miljardit krooni. Peamisteks partnerriikideks olid 2008. aasta jaanuar-oktoober Soome, Rootsi, Venemaa ja Saksamaa. Graafikud. Tabelid

  10. Eesti väliskaubandus aastal 2007 = Estonian's foreign trade in 2007 / Allan Aron, Riina Kerner

    Index Scriptorium Estoniae

    Aron, Allan

    2008-01-01

    Eesti väliskaubanduse näitajatest 2007. aastal: Eesti kaupade eksport oli 125,5 miljardit krooni, import 177,1 miljardit krooni, kaubavahetuse puudujääk oli 51,6 miljardit krooni. Peamisteks partnerriikideks olid 2007. aastal Soome, Rootsi ja Läti. Olulisemad ekspordi- ja impordiartiklid. Graafikud. Tabel. Diagrammid

  11. Fotokaameraga Sotšis, Adleris ja Eesti Aiakeses / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2009-01-01

    Ants Paju, kunstnik Tiina Sääliku ja Tartus tegutseva Tarbatu segakoori osalemisest 13. septembril Anton-Hansen Tammsaare majamuuseumi taasavamisel Sotši lähedal külas Eesti Aiake (kohtuti ka kohalike eestlaste kooriga Sügis), kontsertidest Sotši sanatooriumides ja orelisaalis. Tiina Säälik avas Jõgeva Kultuurikeskuse galeriis reisipiltidega fotonäituse

  12. Suulise eesti keele korpus ja inimese suhtlus arvutiga / Tiit Hennoste, Olga Gerassimenko, Riina Kasterpalu ... [jt.

    Index Scriptorium Estoniae

    Hennoste, Tiit, 1953-

    2009-01-01

    Tutvustatakse Tartu Ülikooli suulise eesti keele korpuse ehitust, transkribeerimise põhimõtteid ja dialoogiaktide annoteerimiseks kasutatavat tüpoloogiat. Inimese ja arvuti vahelise suhtluse rakendusena analüüsitakse ametiasutustesse helistavate klientide esmaseid päringuid

  13. Nagu Indiana Jones / Riina Mägi ; komment. Märt Väljataga

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2008-01-01

    Poola Vabariigi saatkonnas esitleti kahte Hendrik Lillepuu tõlkeraamatut: Herbert, Zbigniew. Valitud luuletused. - Jõgevamaa : H. Lindepuu, 2008 ja Szymborska, Wislawa. Oma aja lapsed. - Laiuse : H. Lindepuu, 2008

  14. Jaapanlased näevad Eestis uut turgu / Kazuhisa Sano ; interv. Riina Luik

    Index Scriptorium Estoniae

    Sano, Kazuhisa

    2005-01-01

    Jaapani suurima turismifirma Japan Travel Bureau tegevjuht vastab küsimustele, mis puudutavad Ettevõtluse Sihtasutusega sõlmitud koostöölepet, turismikoostöö arendamist Eestiga, jaapani turistide huvi Soome vastu, muljeid Eestist. Lisa: Jaapanlased Eestis

  15. Zhenshtshina, razozlivshaja Putina = Naine, kes vihastas Putinit / Astrid Kannel ; interv. Riina Luik

    Index Scriptorium Estoniae

    Kannel, Astrid, 1967-

    2006-01-01

    Ajakirjanik vastab küsimustele, mis puudutavad Võidupäeva pidustuste raames Moskvas toimunud Venemaa presidendi Vladimir Putini pressikonverentsi, ajakirjanikutööd, eraelu ning hobisid. Lisa: Astrid Kannel CV

  16. Sinine Laguun - sinine pärl mustade laavaväljade embuses / Riina Luik

    Index Scriptorium Estoniae

    Luik, Riina, 1962-

    2010-01-01

    Islandi loodusest, geisritest ning kuumaveeallikatest ja nende kasutamisest saare kütteallikatena ning spaaturismis, täpsemalt Sinise Laguuni nimelise termaaljärve juurde ehitatud ülimoodsast sama nimelisest kompleksist, kus on nii spaa, restoran, kliinik psoriaasihaigetele, kui ka konverentsikeskus

  17. Mozarti kadunud autograaf võtab publiku ees kuju / Riina Luik

    Index Scriptorium Estoniae

    Luik, Riina, 1962-

    2011-01-01

    Eesti Ajaloomuuseumis asuvast Mozarti autograafist 27. klaverikontserdi B-duur käsikirjast. Tiina Õuna uurimistööst Mozarti noodikäsikirja teekonna Viinist Tallinna uurimisel. 30. septembril Estonia kontserdisaalis toimuvast kontserdist, kus ettekandele tuleb ka 27. klaverikontsert

  18. Archaeological Excavations at Musumägi hill in Viljandi / Riina Rammo, Martti Veldi

    Index Scriptorium Estoniae

    Rammo, Riina

    2005-01-01

    Erinevate kultuurkihtide leiumaterjalist, nendes esinenud loomaluudest ja keraamikast. Musta kultuurkihi võib dateerida viikingiaega ja pruun kiht annab tunnistust inimtegevusest mäel veel hilisrauaajal.

  19. Kavandatavad muudatused puuetega inimeste sotsiaaltoetuste süsteemis / Riina Riisalo

    Index Scriptorium Estoniae

    Riisalo, Riina

    2006-01-01

    Puuetega inimeste sotsiaaltoetuste seaduse muudatustest, mille jõustumisel 2008. aastal paranevad puuetega inimeste võimalused saada teenuseid, vajalikul määral toetuseid ja konkureerida tööturul. Erinevate vanuserühmade puhul hakatakse rakendama erinevaid sotsiaaltoetuste määramise skeeme

  20. Archaeological investigations in medieval Viljandi the castle and its surroundings / Arvi Haak, Riina Juurik

    Index Scriptorium Estoniae

    Haak, Arvi

    2007-01-01

    Kaevamistest ordulinnuses, uuringutest III eeslinnusel (Esimesel Kirsimäel) peavärava piirkonnas, järelevalvetöödest linnusest lääne poole jääval alal, uuringutest Tartu tänav 28A ja 30 kruntidel. Keraamikaleidude põhjal tekkis asustus Tartu tänav 30 piirkonnas 14. sajandi teisel poolel või veelgi varem

  1. Rain Sepp - kontorita juht ülemaailmses äris / Riina Kallas

    Index Scriptorium Estoniae

    Kallas, Riina

    2005-01-01

    Mobiiltelefonilogosid ning -helinaid müüva Jipii! portaali rahvusvahelise võrgu juht Rain Sepp ettevõtte arengust ja teenustest, tööst rahvusvahelise võrgu juhina, töö spetsiifilisusest, Eesti meeskonnast ning Läti, Leedu, Soome ja Londoni tiimis valitseva tööõhkkonna erinevustest. Vt. samas: 10% muusikarahast tuleb helinast; iTouch plc; www.jippii.ee

  2. Alguses oli HELI ja PÄRT, siis Jalaka LAVASTUS / Riina Luik

    Index Scriptorium Estoniae

    Luik, Riina, 1962-

    2010-01-01

    Tõnu Kaljuste ja Peeter Jalaka lavastusest "Alguses oli", lavastuse aluseks Arvo Pärdi teosed "In Principio" ja "Miserere", 17. augustil Noblesse valukojas toimunud etendusest, muusikaline juht Tõnu Kaljuste. Arvo Pärdi pidunädalate ürituste loetelu

  3. Palamusel näidatakse "Pingviinide marssi" / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2006-01-01

    AS Tallinnfilm ja Palamuse rahvamaja vahel sõlmitud kokkuleppe järgi hakkab Tallinnfilm väärtfilme Palamusele tooma iga kuu. Esimesena tuuakse näha Prantsusmaa 2005.a. valminud dokumentaalfilm "Pingviinide marss" ("La Marche de l'empereur") : režissöör Luc Jacquet

  4. Kaks näitlejapreemiat Viribus Unitisele / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2008-01-01

    13. apr. lõppenud üleriigilisest kooliteatrite festivalist. Jõgevamaad esindav Põltsamaa kultuurikeskuse näitering Viribus Unitis võitis kaks näitlejapreemiat. Need said Veiko Porkanen ja Priit Pius

  5. Eestlased saavad arengumaade õnnele söömisega kaasa aidata / Riina Kuusk ; interv. Andres Reimer

    Index Scriptorium Estoniae

    Kuusk, Riina

    2008-01-01

    Õiglase kaubanduse kaubamärgi Fair Trade esindaja vastab küsimustele, kas Eesti ostjat saab meelitada õilsate eesmärkide nimel rohkem maksma, kas eestlane on valmis oma tarbimist muutma, et kusagil kaugel mõnd inimest toetada, milline läbimüügisiht on Fair Trade'il Eestis, kas õiglane kaubandus võib oma pakkumiste ja kampaaniatega hakata ohustama Eesti põllumeest

  6. Minimalism, sooja südamega / Malle Pajula, Eva Toome ; kommenteerinud Riina Harik

    Index Scriptorium Estoniae

    Pajula, Malle, 1971-

    2009-01-01

    Perekond Kremmi napi ja läbimõeldud kujunduse ning tervikliku valguslahenduse ja välibasseiniga eramust Tiskres, mis pälvis konkursil "Kaunis Kodu 2008" sisekujundaja kaasabil loodud kauneima kodu tiitli

  7. Retsepte äärmise vaesuse likvideerimiseks meie eluajal / Riina Kuusik

    Index Scriptorium Estoniae

    Kuusik, Riina

    2005-01-01

    Raamatu "The end of poverty: economic Possibilities of our time" autor, ÜRO peasekretäri erinõunik prof. Jeffrey Sachs tõdeb, et esmakordselt ajaloos on praegusel põlvkonnal äärmise vaesuse likvideerimiseks arengumaades vajalikud teadmised, oskused ja vahendid. Autor paneb arenenud riikidele südamele, et arenguabi tõstmine 0,7%-ni SKP-st võib 2025. aastaks aidata 1/5 elanikkonnast nn arenguredeli esimesele pulgale

  8. President Ilves ja Simon Peres avasid Tallinna uue sünagoogi / Evely Baum, Riina Leminsky

    Index Scriptorium Estoniae

    Baum, Evely

    2007-01-01

    16. mail 2007 avati pidulikult Tallinna uus juudi sünagoog. Avamistseremoonial osalesid ka Eesti president Toomas Hendrik Ilves ja peaminister Andrus Ansip, Iisraeli asepeaminister Simon Peres, Iisraeli pearabi Yona Metzger, Venemaa pearabi Berl Lazar

  9. Ilmar Külveti mälestusteose esitlus Tartus / Riina Kindlam

    Index Scriptorium Estoniae

    Kindlam, Riina, 1969-

    2005-01-01

    7. novembril 2005 Eesti Kirjandusmuuseumis. Kogumik pealkirjaga "Vana arm ei roosteta" ilmus ajakirjaniku 85. sünnipäevaks. Raamatuesitlusel esinesid Anne Valmas, Janika Kronberg, Vaike Külvet, Piret Noorhani

  10. Ellunäod toovad välja "Rasputini" / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2008-01-01

    7. aug. Pilistvere vanas rehehoones esietenduvast Ain Saviaugu kirjutatud ja lavastatud suvetükist "Rasputin". Suvelavastuse toob välja Põltsamaa Teater Ellunäod koos professionaalsete näitlejatega. Nimiosas mängib näitlejast riigikogulane Indrek Saar

  11. Hotelli Telegraaf sisekujundus. Tallinn, Vene 9 / Külli Salum, Riina Harik, Martin Aunin

    Index Scriptorium Estoniae

    Salum, Külli, 1971-

    2008-01-01

    I ja II korruse plaan, värv. välisvaade, 18 sisevaadet; fotod: Kaido Haagen; juurdeehituse arhitekt: M. Aunin. Sisearhitektid K. Salum ja R. Harik pälvis Eesti Sisearhitektide Liidu 2007. a. ajaloolise interjööri preemia

  12. Eetiline mood Londoni moenädalal / Riina Õun

    Index Scriptorium Estoniae

    Õun, Riina

    2009-01-01

    Londoni moenädala märksõnadeks olid keskkonnasäästlikkus, õiglane kaubandus (fair trade), sotsiaalne vastutus jne. Keskkonnaõigluse fondi EJF puuvillavastasest kampaaniast. Messil osalenud disainerite loomingust

  13. Presidendipaar külastas New Yorgi Eesti Kooli / Kärt Ulman ; fotod: Riina Sõrra

    Index Scriptorium Estoniae

    Ulman, Kärt

    2010-01-01

    President Toomas Hendrik Ilves ja proua Evelin Ilves külastasid 25. septembril 2010 New Yorgi Eesti Kooli. Õhtusel vastuvõtul kohalikele eestlastele tutvustas president programmi "Talendid koju". Proua Evelin Ilvesel oli võimalus USA presidendi abikaasa Michelle Obama kutsel külastada mahefarmi Stone Barnsis. Töövisiit Ameerika Ühendriikidesse 20.-27.09.2010

  14. Viis raamatutäit poola näidendeid / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2006-01-01

    Tõlkija Hendrik Lindepuult ilmus viies tõlkekogumik poola dramaturgia tippteoseid tutvustavast sarjast. Seekord said kaante vahele Tadeusz Rozewiczi näidendid "Valge abielu", "Lõks" ja "Vana naine haub"

  15. Linnapea, keda rõõmustab titekisa / Jüri Ratas ; interv. Riina Luik

    Index Scriptorium Estoniae

    Ratas, Jüri, 1978-

    2006-01-01

    Tallinna linnapea vastab küsimustele, mis puudutavad tema suhtumist opositsiooni kriitikasse, linna juhtimist, perekonda, lapsepõlve, spordiga tegelemist, sõpruskonda, eraettevõtlusest loobumist ning suhteid kirikuga. Lisa: Jüri Ratas (27). Vt. samas lühiintervjuud linnapea abikaasa Karin Ratasega. Kommenteerib Jüri Ratase endine klassijuhataja Nõmme gümnaasiumist, võrkpallitreener Raimund Pundi

  16. Sotsiaaltöötaja muutuvas keskkonnas / Riina Kiik, Arne GrınningsΜter

    Index Scriptorium Estoniae

    Kiik, Riina, 1967-

    2006-01-01

    Tartu Ülikooli ning Norra töö- ja sotsiaaluuringute instituudi Fafo projekti "Vaesus, sotsiaalabi ja sotsiaalne kaasatus - arengud Eestis ja Lätis võrdlevas perspektiivis" käigus uuriti sotsiaaltöö ning sotsiaalpoliitika suhteid, sotsiaaltöö abi vajavate sihtrühmade muutumist. Skeem. Tabel. Vt. samas: Lõppes Eesti, Läti ja Norra ühine uurimisprojekt

  17. Nord Streami keskkonnamõjude aruanne jätab tähelepanuta Läänemere eripära / Madis Filippov ; kommenteerinud Ivar Puura, Tarmo Soomere, Endel Lippmaa

    Index Scriptorium Estoniae

    Filippov, Madis

    2009-01-01

    Teadlastes tekitavad ärevust Vene-Saksa ühisfirma Nord-Streami poolt Läänemerre kavandatava gaasitoru keskkonnamõjud. Artiklis on juttu ka Eesti Teaduste Akadeemia kirjast president Toomas Hendrik Ilvesele ja peaminister Andrus Ansipile sooviga moodustada professionaalne komisjon, mis töötaks läbi Nord Streami gaasijuhtme keskkonnamõju hindamise materjalid. Vt. samas: Dioksiinide kontsentratsioon setetes; Nord Streami gaasijuhe

  18. Kirev moepillerkaar / Britt Rosen

    Index Scriptorium Estoniae

    Rosen, Britt, 1968-

    2008-01-01

    FIBITi moepäevad ja Kuldnõela gala Viru keskuses. Eesti parima moekunstniku tiitli pälvis Riina Põldroos. Kommentaarid Riina Põldroosilt, Aldo Järvsoolt, Urmas Väljaotsalt, Kirill Safonovilt. 17 ill

  19. Stalo izvestno imja lutshshego dizainera Estonii za proshlõi god

    Index Scriptorium Estoniae

    2008-01-01

    Kuldnõela nominentide gala toimus 7. märtsil FIBIT moepäevadel Viru Keskuses. Kuldnõela auhinna sai Riina Põldroos. Riina Põldroosi, Jaanika Sootna, Oksana Tanditi ja Tiia Orgna kollektsioonidest sõnas ja pildis

  20. Kodutus Eestis - kas indiviidi või ühiskonna probleem? / Jüri Kõre, Riina Kiik, Eva Kõiv

    Index Scriptorium Estoniae

    Kõre, Jüri, 1953-

    2005-01-01

    Kodutuse ajaloolisest taustast ja põhjustest. Tartu linna kodutute hulgas 2003.-2004. a. tehtud uurimusest ning Eva Kõivu magistritööst "Kodutus Tartu linnas: Põhjused ja võimalikud lahendused". Diagrammid: Tartu koduta inimeste jaotus kodutuse kestuse järgi; Intervjueeritute sissetulekuallikad

  1. Ärma talu iseteadlik perenaine Evelin Int-Lambot / Evelin Int-Lambot ; interv. Riina Luik

    Index Scriptorium Estoniae

    Int-Lambot, Evelin, 1968-

    2004-01-01

    Eesti tipp-poliitiku Toomas Hendrik Ilvese abikaasa, paljude arvamuslugude autor räägib oma elust metsatalus, lapse kasvatamisest, poliitikast, elu väärtushinnangutest. Kommenteerivad: Rain Pikand, Ando Kiviberg

  2. Jaan Poska 150. sünniaastapäevaks valmib temast kõnelev film / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2015-01-01

    Juristi ja poliitiku Jaan Poska elust ja tema pärandist valmiva filmi produtsent ja režissöör on Toomas Lepp, üks stsenariste Peeter Järvelaid. Filmi kohta jagab selgitusi Tallinna Ülikooli õigusajaloo ja võrdleva õiguse professor ning sihtasutuse Jaan Poska Mälestusfond nõukogu esimees Peeter Järvelaid

  3. Juhan Parts : "Panus tuleks teha tipptehnoloogiale ja koostööle teadlastega" / Juhan Parts ; interv. Riina Mägi

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2007-01-01

    Jõgevamaal visiidil viibinud majandusminister Juhan Parts ettevõtete Valmeco ja Werol Tehased külastusest ja seal nähtust, Venemaa puidutarnetest, Eesti metsanduspoliitikast, Tallinn-Tartu maantee ehitusest, reisirongiliiklusest, ettevõtluse arengu võimalustest regioonis

  4. Muhu uhkus - Pädaste Mõis sai esimeseks viietärni-hotell väljaspool Tallinna / Riina Luik

    Index Scriptorium Estoniae

    Luik, Riina, 1962-

    2009-01-01

    Augustis 2009 tunnustas Eesti Hotellide ja Restornide Liit Pädaste Mõisa neljanda hotellina Eestis ja esimesena väljaspool Tallinna asuvaks viietärni-hotelliks. Pädaste mõisa rajatud spa-hotelli ja restorani tootearendusest

  5. Liisingfinatseerimise olemus ja õiguslik regulatsioon : [bakalaureusetöö] / Riina Raie ; Akadeemia Nord, õigusteaduskond ; juhendaja: Liia Kubja

    Index Scriptorium Estoniae

    Raie, Riina

    2001-01-01

    Liisingfinantseerimise alused, mõiste, liisingu rahvusvaheline laienemine, areng Eestis, liisingu maksustamine ja raamatupidamisarvestus, liisingfinantseerimise teostamine, liisingfinantseerimise pettused

  6. Eesti ettevõtete kaubavahetus tehnoloogilisuse vaatepunktist = Trade of Estonia's enterprises from point of view of technology / Riina Kerner

    Index Scriptorium Estoniae

    Kerner, Riina

    2011-01-01

    Tööstusharude jaotus tehnoloogilise intensiivsuse järgi. Töötleva tööstuse kaubavahetuse areng ja statistika, teadlaste ja inseneride arv. Eesti võrdlus teiste Euroopa Liidu riikidega. Tabelid

  7. Nord Streami mõjudest rääkimine tõi auhinna / Madis Filippov

    Index Scriptorium Estoniae

    Filippov, Madis

    2011-01-01

    Tallinna Tehnikaülikooli juhtivteaduri Tarmo Soomere juhitud uurimisprojekt "Baltic Way" sai Läänemere organisatsioonide konsortsiumi Bonus auhinna Nord Streami võimalike keskkonnamõjude tutvustamise eest

  8. Lootsikulood... Soomaa...

    Index Scriptorium Estoniae

    2005-01-01

    29. sept. esines Kärdla kultuurikeskuses ühendus Kummutikunst. Kata-Riina Luide esitas mononäidendi "Lootsikulood". Dekoratsiooniks oleva slaidiprogrammi autor on Tiit Leito. Lavastas Kata-Riina Luide. Autor ja puukujude valmistaja Andres Koidu. Kummutikunsti on asutanud Ugala teatri näitleja Kata-Riina Luide ja puukujur Andres Koidu

  9. Ordinance No. 054/PRG/SGG/87 on conditions of entry and stay in the Republic of Guinea, 22 July 1987.

    Science.gov (United States)

    1989-01-01

    An ordinance passed on July 22, 1987, governs the entry and residence of foreigners in Guinea. Passports are required for everyone but citizens of Guinea, and entry visas are necessary unless a person is in transit on a ship or airplane or is a citizen of a country which has a reciprocity agreement with Guinea. The entry visa, which is valid for 3 months, is gained by submitting a written request, proof of financial means, a return ticket or security deposit, and 2 photographs. The request may be granted or denies without explanation. Further entry requirements are a valid medical certificate and, if employed in Guinea, an approved employment contract. A transit visa is required of foreigners staying for no more than 5 days, unless they stay n areas designated by competent authorities. A temporary stay visa (renewable once) is required for foreigners who are staying from 5-90 days; they, like all foreigners in Guinea, must have a return ticket or means to leave. Foreigners who wish to stay in Guinea after expiration of their 90-day visa (except accompanied minors, citizens of certain countries, and diplomats) must obtain an extended stay visa, a residence permit, and an allied card. Experts working for the government of Guinea on a longterm basis need an expert resident identity card. Foreigners who wish to reside in Guinea must obtain a foreign resident card or alien card. Refugees and stateless persons must acquire a political refugee or stateless person identification card. To obtain a residence permit, foreigners must have entered Guinea, legally, paid visa and permit taxes, and have an extended stay visa, a certificate of recent physical examination, a work permit, and an employment contract. This permit may be renewed or replaced if lost. An alien card must be obtained by foreigners over the age of fifteen who work in Guinea and want to establish residence; this is issued after the foreigner has paid a tax and gotten an extended stay visa. Foreigners are permitted to move freely in the country, except in places designated by policy or security forces. Holders of alien cards or work permits must notify authorities if they change their address. Landlords, in turn, must notify authorities if they have foreigners as tenants. A foreign resident care and work permit are required in order to secure employment. In general, travelers and temporary residents are not allowed to hold a job. Employers who hire a foreigner must notify the National Employment Office and Immigration authorities. A foreigner's stay may be terminated by public authorities at any time. Those who help a foreigner enter, move through, or stay in the country illegally can be punished.

  10. Comparative evaluation of fluoride release from PRG-composites and compomer on application of topical fluoride: An in-vitro study

    Directory of Open Access Journals (Sweden)

    Dhull K

    2009-03-01

    Full Text Available Aims and Objective: To determine the fluoride release from Giomer and Compomer, using different topical fluoride regimes, and to compare the amount of fluoride release from giomer with that of compomer. Materials and Method: Forty-eight specimens of each giomer and compomer were divided into four treatment groups, namely, control group, fluoridated dentifrice (500 ppm once daily group, fluoridated dentifrice (500 ppm twice daily group, fluoridated dentifrice (500 ppm once daily + fluoridated mouthwash (225 ppm group. Each specimen was suspended in demineralizing solution for six hours and remineralizing solution for 18 hours. Fluoride release was measured in both the demineralizing solution and remineralizing solution daily for seven days. Total daily fluoride release for each specimen was calculated by adding the amount released in the demineralizing solution to that released in remineralizing solution. Results and Conclusion: The fluoride release (ppm was found to be more in Giomer when compared to Compomer. The fluoride released from Giomer and Compomer was significantly greater in the acidic demineralizing solution than in the neutral remineralizing solution. It was found that increasing fluoride exposure significantly increased fluoride release from the giomer and compomer. It was found that the fluoride release from the subgroups of giomer and compomer was in the following order: fluoridated dentifrice twice daily > fluoridated dentifrice once daily + fluoridated mouthwash > fluoridated dentifrice once daily > control group. It was found that the giomer showed a greater fluoride uptake than the compomer.

  11. Measurement of backbone hydrogen-deuterium exchange in the type III secretion system needle protein PrgI by solid-state NMR

    Science.gov (United States)

    Chevelkov, Veniamin; Giller, Karin; Becker, Stefan; Lange, Adam

    2017-10-01

    In this report we present site-specific measurements of amide hydrogen-deuterium exchange rates in a protein in the solid state phase by MAS NMR. Employing perdeuteration, proton detection and a high external magnetic field we could adopt the highly efficient Relax-EXSY protocol previously developed for liquid state NMR. According to this method, we measured the contribution of hydrogen exchange on apparent 15N longitudinal relaxation rates in samples with differing D2O buffer content. Differences in the apparent T1 times allowed us to derive exchange rates for multiple residues in the type III secretion system needle protein.

  12. Partiklid jah, jaa ning jajaa naaberpaari järelliikmena müügiläbirääkimistes / Riina Kasterpalu

    Index Scriptorium Estoniae

    Kasterpalu, Riina

    2005-01-01

    Vastavate partiklite funktsionaalsetest ülesannetest, kasutamisest ja tähendustest müügivestlustes telefoni teel peetud müügiläbirääkimisi analüüsides. Järgneb: Keel ja Kirjandus, 2005, nr. 12

  13. Linnateatri uhiuuel plaadil laulavad näitlejad Olav Ehala laule / Olav Ehala, Riina Roose ; intervjueerinud Maria Lee Liivak ; toimetanud Triin Sinissaar

    Index Scriptorium Estoniae

    Ehala, Olav, 1950-

    2010-01-01

    "Thijl Ulenspiegeli" lavastustest Eestis, heliplaadist "Thijl Ulenspiegel ja teisi laule". Plaadil esitavad O. Ehala muusikat Tallinna Linnateatri näitlejad Tallinna Kammerorkestri saatel. CD-plaadile salvestatud laule sai kuulda kontsertidel "Tallinna Linnateatel laulab. Õnnelik õhtu"

  14. Eesti lasteaed - tänavune laureaat / Muusa Ericsson, Silvi Somp, Riina-Maj Larsson-Mänd ; küsitl. Mai Raud-Pähn

    Index Scriptorium Estoniae

    Ericsson, Muusa

    1996-01-01

    EV 78. aastapäeval, 24. veebruaril 1996 Stockholmi Eesti Majas korraldatud Rootsi Eestlaste Liidu vastuvõtul tehti teatavaks REL Kultuuriauhinna kolleegiumi otsus anda 1996. a. auhind Eesti Lasteaiale

  15. Eesti kaubavahetus majanduse põhikategooriate järgi = Foreign trade of Estonia by broad economic categories / Riina Kerner, Allan Aron

    Index Scriptorium Estoniae

    Kerner, Riina

    2010-01-01

    Eesti väliskaubanduse näitajatest 2009. aastal: Eesti kaupade eksport oli 101,3 miljardit krooni, import 114,1 miljardit krooni, kaubavahetuse puudujääk oli 12,8 miljardit krooni. Majanduse põhikategooriate järgi oli suurim osatähtsus kaubavahetuses vahetarbekaupadel, neile järgnesid tarbekaubad ja kapitalikaubad. Diagramm. Graafikud

  16. Eesti saetööstuse konkurentsivõime analüüs / Riina Lättemägi, Priit Vahter

    Index Scriptorium Estoniae

    Lättemägi, Riina

    2004-01-01

    Eesti saetööstuse konkurentsivõimest läbi konkurentsivõime indeksite ja ekspordi turuosade. Kodumaiste ning välisinvesteeringuga ettevõtete ekspordile orienteerituse ja tootlikkuse võrdlus. Graafikud. Tabelid

  17. TEMPUS Joint European Project CD-JEP-25227-2004 "Health promotion and nurses' guidance skills" / Tiina Juhansoo, Mare Tupits, Riina Shor

    Index Scriptorium Estoniae

    Juhansoo, Tiina

    2008-01-01

    Rahvusvahelisest projektist, mille eesmärk oli ette valmistada õppekavad õendus- ja ämmaemanduse eriala üliõpilastele ning töötavatele õdedele kroonilise haiguse puhuse tervisedenduse ja haigusega toimetuleku õpetamiseks nii haigele kui tema pereliikmele

  18. Rahvastiku elamistingimused Euroopa riikides rahvaloenduste andmetel = The living conditions of the population in European countries according to the data of population censuses / Riina Leinbock

    Index Scriptorium Estoniae

    Leinbock, Riina

    2005-01-01

    Eesti rahvastiku elamistingimuste võrdlus teiste Euroopa Liitu kuuluvate riikide rahvastiku elamistingimustega, mis põhineb Euroopa Liidu Statistikaameti poolt Euroopa riikides aastatel 1999-2002 korraldatud rahvaloenduste ja Eestis 2000. aastal läbi viidud rahvaloenduse tulemustel. Diagrammid

  19. Kummutikunstnikud jutustavad lugusid / Aime Jõgi

    Index Scriptorium Estoniae

    Jõgi, Aime, 1958-

    2005-01-01

    Ühendus Kummutikunst esitab 28. augustil Soomaa Rahvuspargi külastuskeskuses lühinäidendi "Lootsikulood", millele järgneb seminar ettekannete ja filmidega. Lav. ja näitleja Kata-Riina Luide. Aut. Andres Koidu. Kummutikunsti on asutanud Ugala teatri näitleja Kata-Riina Luide ja puukujur Andres Koidu

  20. Progesterone PLGA/mPEG-PLGA Hybrid Nanoparticle Sustained-Release System by Intramuscular Injection.

    Science.gov (United States)

    Xie, Bin; Liu, Yang; Guo, Yuting; Zhang, Enbo; Pu, Chenguang; He, Haibing; Yin, Tian; Tang, Xing

    2018-02-14

    To prepare sustained-release PLGA/mPEG-PLGA hybrid nanoparticles of progesterone (PRG), and evaluate the descending required administration dosage in vivo. PRG hybrid nanoparticles (PRG H-NPs) based on PLGA/mPEG-PLGA were compared with PRG nanoparticles (PRG-NPs) of pure PLGA as the matrix and PRG-oil solutions. Nanoparticles (NPs) were formed by the method of nanoemulsion, and the pharmacokinetics of the sustained-release PRG H-NPs in male Sprague dawley (SD) rats were investigated. The rats were randomly divided into four groups, each group received: single dose of PRG H-NPs (14.58 mg/kg, i.m.) and PRG-NPs (14.58 mg/kg, i.m.), repeated dosing for 7 days of PRG-oil (2.08 mg/kg, i.m.) solution (Oil-L) and a higher dosage of PRG-oil (6.24 mg/kg, i.m.) solution (Oil-H), respectively. In the pharmacokinetic test, the PRG H-NPs exhibited a comparatively good sustained-release effect against the PRG-NPs without mPEG-PLGA and PRG-oil solution. The pharmacokinetic parameters of the PRG H-NPs, PRG-NPs, Oil-L and Oil-H were AUC 0-t (ng·h·mL -1 ) 8762.1, 1546.1, 1914.5, and 12,138.9, t 1/2 (h)52.7, 44.1, 8.4 and 44.6 respectively. Owing to the modification of PEG, PRG H-NPs can act as safe delivery platforms for sustained-release of drugs with a lower dosage required.

  1. Concerns about pregabalin: further experience with its potential of causing addictive behaviors

    NARCIS (Netherlands)

    Gahr, M.; Franke, B.; Freudenmann, R.W.; Kolle, M.A.; Schonfeldt-Lecuona, C.

    2013-01-01

    Pregabalin (PRG) is approved for the treatment of neuropathic pain, partial seizures, and generalized anxiety disorder in many countries. Supported by case reports and a few studies there is an ongoing debate on PRG's potential to cause addictive behaviors. Considering that PRG is currently under

  2. The Iron Age and 13th-18th century Cemetery and Chapel Site of Niklusmägi : Grave Looting and Archaeology / Heiki Valk, Pikne Kama, Riina Rammo ... [jt.

    Index Scriptorium Estoniae

    2013-01-01

    2011. aastal anti arheoloogilidele vihje Niklusmäe kalme lõhkumisest. 2012. aasta suvel leidsid projekti "Arheoloogia, võim ja ühiskond" raames aset arheoloogilised päästeuuringud. Ilmnes, et kalmet oli rüüstatud 4-5 aasta jooksul. Leitud luustikest, hauapanustest. Niklusmäest Läti Henriku kroonika andmetel. Tänini räägib pärimus Lätist tulnud, Niklusmäe metsa läbivast ja Sangaste poole suunduvast sõjateest. Leiud on tõstatanud küsimusi Eesti lõunaserva matmiskommete ja etnokultuuriliste olude kohta. Kuna kalmesüdamik on rüüstatud, jäävad küsimused vastuseta

  3. Pre-Viking and early Viking Age sacrifical place at Viidumäe, west Saaremaa / Marika Mägi, Indrek Jets, Riina Riiel, Raili Allmäe

    Index Scriptorium Estoniae

    2015-01-01

    Viidumäe ohverduskoht on eriti märkimisväärne selle poolest, et kuulub perioodi,millest Saaremaal muistised peaaegu puuduvad. Leiukoht osutab, et Eesti rannikukultuuri skandinaavitumine, mis on jälgitav alates 10. sajandist, sai alguse juba hiljemalt 8. sajandil

  4. Euroopa Liidu 10 uue liikmesriigi väliskaubandus aastatel 2004-2007 = Foreign trade of the 10 new member states of EU in 2004-2007 / Riina Kerner

    Index Scriptorium Estoniae

    Kerner, Riina

    2008-01-01

    Artiklis analüüsitakse uute ja vanade liikmesriikide väliskaubanduse arengut, Euroopa Liiduga ühinemise mõju Eesti väliskaubandusele, Eesti ja teiste uute liikmesriikide väliskaubanduse ühiseid ja erinevaid jooni. Tabelid, graafikud, diagrammid

  5. "Mina olin siin", võib vastu hambaid saada / Andres Keil

    Index Scriptorium Estoniae

    Keil, Andres, 1974-

    2007-01-01

    Noortefilmi "Mina olin siin" võtetel. Filmi aluseks on Sass Henno romaan "Mina olin siin. Esimene arest", stsenaariumi kirjutas Ilmar Raag, lavastab Rene Vilbre, operaator on Mait Mäekivi, peaosas Rasmus Kaljujärv, produtsendiks Riina Sildos

  6. Sass Henno romaani järgi valmib film

    Index Scriptorium Estoniae

    2007-01-01

    Tallinnas jätkuvad noortefilmi "Mina olin siin" võtted. Filmi aluseks on Sass Henno romaan "Mina olin siin. Esimene arest", lavastab Rene Vilbre, peaosas on Rasmus Kaljujärv, produtsendiks Riina Sildos

  7. Õpetaja ja õpilane vahetavad päid Ugalas ja NO-s / Margus Mikomägi

    Index Scriptorium Estoniae

    Mikomägi, Margus, 1956-

    2009-01-01

    Ugala teatri lavastusest "Nii nagu taevas" (Kay Pollaki samanimelise filmi dramatiseering), lavastaja Ingo Normet. Margus Vaheri ja Kata-Riina Luide osatäitmistest. Ka lavastusest "Pea vahetus" NO99 teatris, autor-lavastaja Uku Uusberg

  8. Suurlinlik lukshotell / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2007-01-01

    Historitsistlikust hoonest Tallinna vanalinnas Vene tn. 9 (1874. a.), arhitekt Peter Schreiberg. Apteegi tänavale jäävast juurdeehitisest, arhitekt Martin Aunin, sisekujundajad Külli Salum ja Riina Harik

  9. Tuul väljal / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet

    1997-01-01

    Arvustus: Woolf, Virginia. Esseed/ inglise k. tlk. Malle Talvet, Jaak Rähesoo. Tallinn : Hortus Litterarum, 1997; Woolf, Virginia. Orlando : elulugu / inglise k. tlk. Riina Jesmin. Tallinn : Perioodika, 1997. (Loomingu Raamatukogu; 31-34)

  10. Antidepressandid tõusev trend / Monica Raud

    Index Scriptorium Estoniae

    Raud, Monica, 1981-

    2013-01-01

    Eesti inimesed neelavad praegu vähemalt kaks korda rohkem antidepressante kui aastatuhande alguses. Miks? selgitavad psühhiaatrid Peeter Jaanson, Andres Lehtmets,Viktooria Saat, perearstid Ingrid Alt ja Riina Raudsik ning mõju kommenteerivad patsiendid

  11. Milline kevad tuleb? / Kätlin Karik

    Index Scriptorium Estoniae

    Karik, Kätlin

    2016-01-01

    Oma kevadisi rõivakollektsioone tutvustavad Ülle Pohjanheimo, Ivo Nikkolo, Althea/Thea Pilvet, Roberta Einer, Monton, Aldo Järvsoo, Ketlin Bachmann, Riina Põldroos, Kriss Soonik, Tiina by Tiina/Tiina Talumees, Iris Janvier

  12. Emotsionaalselt raske vabadus / Teeli Remmelg

    Index Scriptorium Estoniae

    Remmelg, Teeli

    2007-01-01

    Endine KPMG osakonnajuht ja tunnustatud maksuspetsialist Kadri Arula leiab, et uue töö leidmine pole sugugi nii lihtne, eriti kui tahetakse vahetada eriala. CV: Kadri Arula. Kommenteerivad Riina Rohelaan ja Mare Teichmann

  13. Praktika õpetab ja avab uksi / Teresa-Katriin Liivak

    Index Scriptorium Estoniae

    Liivak, Teresa-Katriin

    2008-01-01

    Oma praktikakogemustest räägivad Tallinna Ülikoolis reklaami ja imagoloogiat õppinud Karl Saluveer, Tööstushariduskeskuses juuksuriks õppiv Riina Valbrit ja Tartu Ülikoolis arstiteaduskonna lõpetanud Krista Täks

  14. Maffia, hullus ja Sannikovi maa / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2011-01-01

    Arvustus: Roberts, Gregory David. Shantaram. 1.-2. raamat / tõlkinud Riina Jesmin. Tallinn : Varrak, 2011 ; Akutagawa, Ryūnosuke. Mandariinid tihnikus. Tallinn : Varrak, 2011 ; Põder, Rein. Kauge. Tallinn : Eesti Raamat, 2011

  15. Heitlik ilm süvendab luu- ja liigesevalu / Anneli Aasmäe

    Index Scriptorium Estoniae

    Aasmäe, Anneli, 1973-

    2008-01-01

    Tartu Ülikooli Kliinikumi sisekliiniku reumatoloogia dotsendi Riina Kallikormi, Kuressaare erakliiniku Luukas reumatoloogi Reinhold Birkenfeldti ja Ida-Tallinna Keskhaigla reumatoloogi Tõnu Peetsi kinnitusel on kõik krooniliste reumaatiliste haigustega inimesed ilmatundlikud

  16. Na dvore zima, na podiume leto / Vladimir Zaitsev

    Index Scriptorium Estoniae

    Zaitsev, Vladimir

    2006-01-01

    Riias toimunud moenädalast Riga Fashion Week. Näidati kollektsioone kevad-suveks 2007. Osalesid moekunstnikud Baltimaadest, Itaaliast ja Venemaalt. Eestit esindasid Oksana Tandit, Riina Põldroos ja Ivo Nikkolo ja firma Sangar

  17. Kazhdõi mog bõ vozglavit Dom... / Fabrizio Talia ; interv. Alina Lind

    Index Scriptorium Estoniae

    Talia, Fabrizio

    2006-01-01

    Moemaja Moschino peadisaineri, SuperNoova žürii liikme Fabrizio Taliaga konkursist SuperNoova, tööst Moschino jaoks. Konkursil osalenutest meeldisid Aldo Järvsoo, Riina Põldroos ja Xenia Jedomskihh

  18. Disainkaminad

    Index Scriptorium Estoniae

    2007-01-01

    Salongides Tulering, Tulepesad ja 12 kaminat ning Tondi kaminasalongis pakutavad kaminad. Kaminad Liina Ainomäe, Annes Arro, Kaire Kemp-Tischleri, Jorma Holmi, Külli Salumi ja Riina Hariku sisekujundusega ning Meelis Pressi prpjekteeritud eramutes

  19. "Berlinale" võistluslainelt / Endel Link

    Index Scriptorium Estoniae

    Link, Endel

    2007-01-01

    Lühidalt 57. Berliini filmifestivalil linastuvatest filmidest. Avafilm on Olivier Dahani "La Mome" Edith Piafist. Lastefilmide võistlusprogrammis on ka "Leiutajateküla Lotte". Riina Sildos on lühifilmide žüriis

  20. Eesti kineastide dessant Berliini / J. R.

    Index Scriptorium Estoniae

    J. R.

    2007-01-01

    57. Berlinale lastefilmide võistlusprogrammis on ka "Leiutajateküla Lotte". Rain Tolk esindab Eestit Euroopa noorte näitlejate tutvustuspromotsioonis Shooting Star. Riina Sildos on lühifilmide žüriis

  1. Res Publica nõuab Leinatammelt 44 600 krooni / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2005-01-01

    Res Publica nõuab Reformierakonda üle läinud Tarmo Leinatammelt maksmata jäänud liikmemaksu, fraktsioon kutsub teda üles loobuma kohast Riigikogus. Erakonna pressiesindaja Riina Vändre selgitus

  2. Estonia film venitab saladuste loori / Heiki Suurkask, Andres Laasik

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2003-01-01

    Saksamaal Berliinis esilinastus poliitiline põnevusfilm "Balti torm" ("Baltic Storm"), mis kujutab parvlaev "Estonia" hukku. Esilinastuse ja filmi ümber toimuvast. Lisatud lühiintervjuu Riina Kionkaga, Eesti suursaadikuga Saksamaal

  3. Lugupeetud kunstnikud, arhitektid ja sõbrad!

    Index Scriptorium Estoniae

    2001-01-01

    Eesti Kunstnike Liidu ja Eesti Arhitektide Liidu aastavahetuspeo kava 28. XII. Esinevad Raivo Kelomees (EKA ja Tartu Kõrgema Kunstikooli videoprojektid), EKA moeosakond. Nova Moda esitleb: Ruta Depp, Ketlin Bachman, Riina Põldroos, Kati Simpson

  4. Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission

    OpenAIRE

    Unichenko, Petr; Kirischuk, Sergei; Yang, Jenq-Wei; Baumgart, Jan; Roskoden, Thomas; Schneider, Patrick; Sommer, Angela; Horta, Guilherme; Radyushkin, Konstantin; Nitsch, Robert; Vogt, Johannes; Luhmann, Heiko J.

    2016-01-01

    Plasticity-related gene-1 (PRG-1) is a brain-specific protein that modulates glutamatergic synaptic transmission. Here we investigated the functional role of PRG-1 in adolescent and adult mouse barrel cortex both in vitro and in vivo. Compared with wild-type (WT) animals, PRG-1-deficient (KO) mice showed specific behavioral deficits in tests assessing sensorimotor integration and whisker-based sensory discrimination as shown in the beam balance/walking test and sandpaper tactile discriminatio...

  5. Archaeological excavations at a bronze age grave and a 6th - 10 th century cult site at Aunamägi in Tõnija-Põlluküla village, southern Saaremaa / Marika Mägi, Raili Allmäe, Riina Riiel ... [jt.

    Index Scriptorium Estoniae

    2015-01-01

    Kaevamised Saunamäel korraldati Tallinna Ülikooli üliõpilaste seminarkaevamistena. Kogu kaevamiste ala moodustas umbes 170 m2. Märkimisväärne Tuulingumäe ja Saunamäe kompleksi juures on see, et need olid mõeldud suhteliselt piiratud hulgale. Sellised väikesed pühapaigad viitavad rituaalidele, mida sooritasid üksikud valitud isikud. Kõik artiklis mainitud kultusekohad jäävad Läänemere põhjaosa rannikualadele, kus eelviikingiajal kujunes ühine kultuurisfäär

  6. Peamised vaidlusküsimused töölepingu lõpetamisel töötajapoolsel töölepingu tingimuste rikkumisel : [bakalaureusetöö] / Riina Rebane ; Tartu Ülikool, õigusteaduskond ; juhendaja: Inge-Maret Orgo

    Index Scriptorium Estoniae

    Rebane, Riina

    2003-01-01

    Üldised lähtekohad, töölepingu lõpetamine tulenevalt töös esinevatest olulistest puudustest, alkoholi tarvitamisest tingitud lõpetamine, omavoliline töölt puudumine, usalduse kaotamine, vääritu teo tõttu, protseduurireeglite järgimisega seotud probleemide tõttu

  7. Algasid Henno "Mina olin siin" järgi tehtava filmi võtted

    Index Scriptorium Estoniae

    2007-01-01

    Eile algasid noortefilmi "Mina olin siin" võtted. Filmi aluseks on Sass Henno romaan "Mina olin siin. Esimene arest", stsenaariumi kirjutas Ilmar Raag, lavastab Rene Vilbre, operaator on Mait Mäekivi, peaosas Rasmus Kaljujärv, produtsendiks Riina Sildos

  8. Suur rahvusvaheline välisbalti arhiivide konverents südasuvises Tartus / Mai Raud-Pähn ; fotod Madis Laas

    Index Scriptorium Estoniae

    Raud-Pähn, Mai, 1920-

    2006-01-01

    Ettekannetega esinesid: Tiiu Kravtsev, Riina Reinvelt, Juta Kivimäe, Piret Noorhani, Merike Kiipus, Anu Korb, Anne Valmas, Mihkel Volt, Mare Rand, Inga Kuljus, Enn Mainla, Roland Weiler, Teas Tanner, Tiina Kirss, Jüri Kivimäe, Enda-Mai Michelson-Holland, Andrae, Carl Göran, Katrin Meerits ja Maie Barrow

  9. Arengukoostöö aitab Nicaraguas kasvatada õiglast kohvi / Silvia Lotman

    Index Scriptorium Estoniae

    Lotman, Silvia, 1980-

    2006-01-01

    Koos Soome Õiglase Kaubanduse propageerijatega Nicaraguas ja Costa Rical viibinud Eesti arengukoostöö eestvedaja Riina Kuusik ja filmioperaator Elen Lotman räägivad kohalike väiketootjate ja läänest appi tulnud Õiglast Kaubandust propageerivate valitsusväliste organisatsioonide koostööst

  10. Baltoscandal näitas Euroopa absurdi / Tiiu Laks

    Index Scriptorium Estoniae

    Laks, Tiiu, 1984-

    2010-01-01

    Rakveres 10. juulil lõppenud 11. rahvusvahelisest teatrifestivalist Baltoscandal. Prantslase Gerald Kurdiani kontsertetendusest "This is the Hello Monster!". Riina Maidre ja Maike Londi kontsertetendusest "PostUganda". Philippe Quesne'i ja tema trupi Vivarium Studio lavastusest "Big Bang". Taani tantsija Mette Ingvartseni lavastusest "Giant City". Akhe inseneriteatri lavastusest "Faust. 2360 sõna". Hollandi trupi Dood Paard lavastusest "Answer Me"

  11. Vene teater = The Russian Theatre

    Index Scriptorium Estoniae

    2007-01-01

    Tallinnas Vabaduse väljak 5 asuva Vene teatri interjööri renoveerimine. Sisearhitekt Aivar Oja (FRA Disain), kaasa töötas Riina Luuk (Vaikla Disain). Sisearhitektidest, nende tähtsamad tööd. 2 plaani, lõige, 10 värv. sisevaadet, fotod sisearhitektidest

  12. Saaremaa - kokkuhoidev kogukond

    Index Scriptorium Estoniae

    2004-01-01

    Saaremaa Politseiprefektuuri töötajad Ants Ley, Meelis Juhandi, Hillar Peegel, Juri Krotman, Veigo Väli, Rainer Antsaar ja Riina Paju. Koostööpartneritena kommenteerivad Prits Liblik, Taivo Vaik, Toomas Luik ja Toomas Kasemaa. Vt. samas: Ajalooline Kuressaare politseimaja

  13. Kes tegelikult lõid Res Publica? / Valeri Kalabugin

    Index Scriptorium Estoniae

    Kalabugin, Valeri

    2005-01-01

    Enne erakonnaks kuulutamist oli Res Publica Eesti iseseisvust ja demokraatiat taotlev ühendus, kuhu on kuulunud mitmed poliitika- ning ühiskonnategelased. Vt. samas: Ühendus Res Publica avaldus. Küsimustele vastavad Res Publica avalike suhete juht Riina Vändre, Riigikogu liige Mart Nutt, ajakirjanik Toomas Kümmel

  14. Kabareeinstallatsioon: uue teatri fragmentaarium / Jürgen Rooste

    Index Scriptorium Estoniae

    Rooste, Jürgen, 1979-

    2016-01-01

    Nüüdisteatri keelest ja kabareelikkusest lavastustes: „Skaala surm” - idee ja lavastus: Riina Maidre ja Nero Urke, „All Tomorrow’s Parties” - autorid Inga Salurand ja Hendrik Kaljujärv, „Location X: Black Side” - esitaja ja koreograaf: Taneli Törma

  15. Nee omingud, päävad ja õhtad / Enda Naaber

    Index Scriptorium Estoniae

    Naaber, Enda, 1938-

    2006-01-01

    Järvesalu, Irma. Nänne kink oo nee õhtad : murdeluulet / toimetaja Kadri Tüür ; illustratsioonid: Viire Jagomägi ; kujundanud Riina Uisk. Tupenurme : I. Järvesalu, 2006. Sisaldab katkendeid luuletustest "Nänne kink", "Me jõudsime mere juure", "Kuoruke" ja "Meri"

  16. Dr. Ruta Kruuda fond andis välja esimesed stipendiumid

    Index Scriptorium Estoniae

    2006-01-01

    Poliitikauuringute Keskuse PRAXIS juurde loodud dr Ruta Kruuda fond andis 10. märtsil 2006. a. välja oma esimesed stipendiumid, mille said Tervise Arengu Instituudi teadur Riina Raudne ja Tartu Ülikooli magistrand Liina Raju. Tema magistritöö keskendub HIV-nakkuse ja AIDSi teema kui avaliku arutelu objekti käsitlusele Eestis

  17. Õitsemise tšempionid püsilillepeenral / Kaja Kurg

    Index Scriptorium Estoniae

    Kurg, Kaja, 1959-

    2014-01-01

    Helga Taimeaia perenaine Ülli-Riina Sildnik soovitab pikalt õitsvaid püsililli: mandel-piimalill Purpurea, harilik ussitatar, suureõieline iminõges, harilik tõrvalill, Borisi mõõl, kurerehad, siberi iiris, vene ussilakk jt

  18. Rahvaliidu kants Palamusel käärib / Rein Sikk

    Index Scriptorium Estoniae

    Sikk, Rein, 1961-

    2010-01-01

    Rahvaliidu Jõgeva maakonna juhi Riina Kulli väitel pole ükski sotsiaaldemokraat ega Rahvaliidu liider käinud kohapeal kahe erakonna võimalikku liitumist selgitamas. Palamuse elanike arvamusi Rahvaliidu ja SDE võimaliku ühinemise kohta

  19. Saksa press käsitleb Estonia huku filmi blufina

    Index Scriptorium Estoniae

    2003-01-01

    Saksamaal esilinastus poliitiline põnevusfilm "Balti torm" ("Baltic Storm"), mis kujutab parvlaev "Estonia" hukku venelaste vandenõu tulemusena. Produtsendid on Jutta Rabe, Kaj Holmberg ja Birgit Stein, režissöör ja üks stsenariste Reuben Leder. Filmi vaieldavast konteptsioonist ja vastukajadest Saksa ajakirjanduses. Ka Eesti suursaadiku Riina Kionka arvamus

  20. FIBIT - Fashion is back in Tallinn / Marina Poltavtseva

    Index Scriptorium Estoniae

    Poltavtseva, Marina

    2004-01-01

    Moepäevad FIBIT Viru keskuses. Üks idee algatajaid on moekunstnik Katrin Kuldma. 1. oktoobril näidatakse soome moekunstniku Ritva-Liisa Pohjalaineni kollektsiooni Allergia - From Dreams to the Unique. Teisi moedemonstratsioone, millede stilistideks on Riina Põldroos, Aldo Järvsoo, Tanel Veenre ja Katrin Kuldma. Rõivad on valitud Viru keskuse kauplustest

  1. Eesti Energia võttis elektri salaja ära : elektritarbija, kellel jäi kord enda süül, siis aga panga, Eesti Energia ja tarbija enda vahelise arusaamatuse tõttu elektri eest tasumata, leidis end ootamatult elektrita jäetuna / Kai Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Kai

    2003-01-01

    Otsekorralduslepinguga elektriarve tasumata jätnud kliendilt elektri väljalülitamisest. Kommenteerivad Eesti Energia pressiesindaja Riina Vändre, tarbijakaitseameti pressiesindaja Kristina Vaksmaa, Hansapanga Eesti meediasuhete juht Kristiina Tamberg ja Eesti Ühispanga pressiesindaja Evelin Pull

  2. Mälu pole ainult meil, vaid ka meie haigustel / Tiina Sarv

    Index Scriptorium Estoniae

    Sarv, Tiina, 1949-

    2007-01-01

    Pärnus toimunud Eesti arstide Astra Zeneca ABC-konverentsi märksõna oli mälu. Konverentsil esinesid professorid Endel Tulving, Alan Altraja ja Anto Raukas, dotsendid Tiina Ristimäe ja Ursel Soomets, kirjandusteadlane Rutt Hinrikus, zooloog Aleksei Turovski ning arstid Anu Ambos ja Riina Kütner

  3. Hea õpetamise grandi saajad

    Index Scriptorium Estoniae

    2016-01-01

    Õpetamise uurimist alustavad grandi toel Andrus Org, Riina Oruaas, Natalja Zagura (humanitaar- ja kunstide valdkond), Stefano Braghiroli, Aet Kiisla, Tiiu Taur (sotsiaalteadused), Marje Oona, Oivi Uibo, Daisy Volmer (meditsiinitead.), Svetlana Ganina, Natalja Lepik ja Raivo Raid (loodus- ja täppistead.)

  4. Kui koolist saab villand / Aivi Pargi

    Index Scriptorium Estoniae

    Pargi, Aivi, 1950-

    2004-01-01

    Mitme riigi pedagoogid leiavad, et põhikoolieas kooli pooleli jätmine on uus sotsiaalne nähtus, mida saab ennetada õpetajatele uusi oskusi andes ning vanematega koostööd tehes. Kommenteerivad Riina Veidenbaum, Tiina Kivirand

  5. Maalehe Raamatu aiaabi

    Index Scriptorium Estoniae

    2007-01-01

    Tallinnas 2006. a. ilmunud raamatust "Praktiline aiarajaja käsiraamat" (toimetaja Deborah Parker, peatoimetaja Christopher Brickell), Herman Hacksteini ja Wota Wehmeyeri "Kiviktaimlaleksikonist" (toimetaja Riina Tammsaar), 2007. a. ilmunud Börje Erikssoni ja Pär Schyllanderi raamatust "Veekogud aias" (toimetajad R. Tammsaar ja Signe Siim, fotod: Bertil K. Johanson), Bertil K. Johansoni raamatust "Aialilled" (toimetaja R. Tammsaar)

  6. Lotte vallutab maailma

    Index Scriptorium Estoniae

    2006-01-01

    Eesti Joonisfilmi täispikk animafilm "Leiutajateküla Lotte", autoriteks Heiki Ernits, Janno Põldma ja Andrus Kivirähk, on kohe valmimas. Filmi tootjate hulka kuuluvad ka Läti stuudio Rija Films ja Eesti Televisioon, projekti produtsent on Riina Sildos

  7. Lotte maandub Cannes'is / Janno Põldma, Heiki Ernits ; interv. Jaan Ruus

    Index Scriptorium Estoniae

    Põldma, Janno, 1950-

    2006-01-01

    Eesti Joonisfilmi täispikk animafilm "Leiutajateküla Lotte", autoriteks Heiki Ernits, Janno Põldma ja Andrus Kivirähk on valmis. Filmi tootjate hulka kuuluvad ka Läti stuudio Rija Films ja Eesti Televisioon, projekti produtsent on Riina Sildos

  8. Sisearhitekt Pille Lausmäe - Tallinna töö- ja toidukultuuri looja / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2006-01-01

    Omanimelise arhitektuuribüroo omanik sisearhitekt Pille Lausmäe oma elust ja tööst, isast sisearhitekt Väino Tammest. Eesti Kunstiakadeemias õpib sisearhitektuuri ka Pille poeg Ville Lausmäe ja töötab ema büroos. Pillet iseloomustavad Priit Põldme, Riina Sildots, Rein Tallermo, Mari Kaljuste

  9. Angela Merkel. Saksa raudne naiskantsler vallutab mõjuvõimsalt maailma / Erkki Bahovski

    Index Scriptorium Estoniae

    Bahovski, Erkki, 1970-

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 6. sept. lk. 7. Ajakiri Forbes on nimetanud Saksamaa kantsleri Angela Merkeli maailma mõjuvõimsamaks naiseks. Riina Kionka ja Andres Kasekamp iseloomustavad kantsleri poliitikat ja rahvusvahelist rolli. Eesti peaministri Andrus Ansipi kohtumistest A. Merkeliga

  10. Kuidas värvata tarka juhti?

    Index Scriptorium Estoniae

    2007-01-01

    Tipp- ja kesktaseme juhtide värbamisest räägivad: Piret Lukk SEB Eesti Ühispangast, Kaidi Kask Rautakesko AS-ist, Sven Suurraid ja Riina Beljajeva Express Post AS-ist, Sirje Tammiste omanimelisest konsultatsioonibüroost, Ursula Muddi Nordnet Eesti AS-ist ja Ülle Matt Elcoteq Eesti AS-ist

  11. Inimese murdmine ühiskonna prismas / Andri Ksenofontov

    Index Scriptorium Estoniae

    Ksenofontov, Andri, 1962-

    2011-01-01

    Epp Kubu näitus "Raha ajab lapsi taga" Tallinna Linnagaleriis 8. maini 2011. Kristina Kiviranna ja Riina-Ingel Keskpaiga ehk Lumi Kylma näitus "Escape" ("Põgenemine") Tallinnas Aatriumi galeriis 21. maini 2011. Johanna Sipilä (Soome) ja Katrin Piile maalinäitus "Jonathan Krani" Tallinnas Polymeri kunstikonteineris 1. maini 2011

  12. Täna õhtul Berliinis, 57. korda / Lauri Kärk

    Index Scriptorium Estoniae

    Kärk, Lauri, 1954-

    2007-01-01

    57. Berlinale avamise eel. Programmidest, ava- ja lõpufilmidest. Lastefilmide võistlusprogrammis on ka "Leiutajateküla Lotte". Rain Tolk esindab Eestit Euroopa noorte näitlejate tutvustuspromotsioonis Shooting Star. Riina Sildos on lühifilmide žüriis

  13. Kino Kosmos Imax = Kosmos Imax cinema / Pille Lausmäe ; kommenteerinud Karen Jagodin

    Index Scriptorium Estoniae

    Lausmäe, Pille, 1958-

    2015-01-01

    Kino Kosmos Imax Tallinnas Pärnu mnt 45. 1964. aastal valminud hoone arhitekt Ilmar Laasi. Renoveeritud interjööri autorid Pille Lausmäe, Kerli Lepp (Pille Lausmäe Sisearhitektuuri büroo). Projekti autorid Urmas Lõoke, Riina Poopuu (Urmas Lõokese Arhitektibüroo)

  14. Telegraafi tunnustati auga olla maailma 65 vingema hotelli hulgas / Mari Kodres

    Index Scriptorium Estoniae

    Kodres, Mari

    2008-01-01

    Tallinna vanalinnas Vene tänav 9 19. saj. hoones asuvast luksushotellist "Telegraaf". Renoveerimisprojekti ja juurdeehituse autor Martin Aunin, sisekujundus Külli Salumilt ja Riina Harikult. Hotell avati 2007. a. mais. Väljaanne Conde Nast Traveller nimetas Telegraafi aasta ihaldatumate hotellide sekka

  15. Linnahall ja tema järelelu = The after-history of the Linnahall concert hall / Andres Kurg

    Index Scriptorium Estoniae

    Kurg, Andres, 1975-

    2012-01-01

    Tallinna Linnahallist, arhitektid Raine Karp ja Riina Altmäe, sisearhitektide rühma juhtis Ülo Sirp. Selle asemel, et kuulutada Linnahall möödunud aegadesse kuuluvaks, võiks autori sõnul teda vaadata sillana mineviku lootuste ja praeguse linnaga seotud soovide vahel

  16. Regulatory approach to NPP ageing in Bulgaria

    International Nuclear Information System (INIS)

    Vassilev, D.

    2000-01-01

    In this contribution summary information of Kozloduy NPP units is presented. The nuclear legislation, regulatory approach for managing safety aspects on NPP ageing, short term programme, complex programme PRG'97 ant other aspects of ageing management are discussed

  17. Probabilistic Rule Generator: A new methodology of variable-valued logic synthesis

    International Nuclear Information System (INIS)

    Lee, W.D.; Ray, S.R.

    1986-01-01

    A new methodology to synthesize variable-valued logic formulas from training data events is presented. Probablistic Rule Generator (PRG) employs not only information-theoretic entropy as a heuristic to capture a path expression but also multiple-valued logic to expand a captured complex. PRG is efficient for capturing major clusters in the event space, and is more general than previous methodologies in providing probabilistic features

  18. A Prototype Model for Automating Nursing Diagnosis, Nurse Care Planning and Patient Classification.

    Science.gov (United States)

    1986-03-01

    Each diagnosis has an assessment level. Assessment levels are defining characteristics observed by the nurse or subjectively stated by the patient... characteristics of this order line. Select IV Order (Figure 4.l.1.le] is the first screen of a series of three. Select IV Order has up to 10 selections...For I F Upatient orders. Input Files Used: IVC.Scr and Procfile.Prg * Output Files Used: None Calling Routine: IUB.Prg * Routine Called: None

  19. Incidence and Management of Bleeding Complications Following Percutaneous Radiologic Gastrostomy

    International Nuclear Information System (INIS)

    Seo, Nieun; Shin, Ji Hoon; Ko, Gi Young; Yoon, Hyun Ki; Gwon, Dong Il; Kim, Jin Hyoung; Sung, Kyu Bo

    2012-01-01

    Upper gastrointestinal (GI) bleeding is a serious complication that sometimes occurs after percutaneous radiologic gastrostomy (PRG). We evaluated the incidence of bleeding complications after a PRG and its management including transcatheter arterial embolization (TAE). We retrospectively reviewed 574 patients who underwent PRG in our institution between 2000 and 2010. Eight patients (1.4%) had symptoms or signs of upper GI bleeding after PRG. The initial presentation was hematemesis (n = 3), melena (n = 2), hematochezia (n = 2) and bloody drainage through the gastrostomy tube (n = 1). The time interval between PRG placement and detection of bleeding ranged from immediately after to 3 days later (mean: 28 hours). The mean decrease in hemoglobin concentration was 3.69 g/dL (range, 0.9 to 6.8 g/dL). In three patients, bleeding was controlled by transfusion (n = 2) or compression of the gastrostomy site (n = 1). The remaining five patients underwent an angiography because bleeding could not be controlled by transfusion only. In one patient, the bleeding focus was not evident on angiography or endoscopy, and wedge resection including the tube insertion site was performed for hemostasis. The other four patients underwent prophylactic (n = 1) or therapeutic (n = 3) TAEs. In three patients, successful hemostasis was achieved by TAE, whereas the remaining one patient underwent exploration due to persistent bleeding despite TAE. We observed an incidence of upper GI bleeding complicating the PRG of 1.4%. TAE following conservative management appears to be safe and effective for hemostasis.

  20. Incidence and Management of Bleeding Complications Following Percutaneous Radiologic Gastrostomy

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Nieun; Shin, Ji Hoon; Ko, Gi Young; Yoon, Hyun Ki; Gwon, Dong Il; Kim, Jin Hyoung; Sung, Kyu Bo [Asan Medical Center, Ulsan University College of Medicine, Seoul (Korea, Republic of)

    2012-03-15

    Upper gastrointestinal (GI) bleeding is a serious complication that sometimes occurs after percutaneous radiologic gastrostomy (PRG). We evaluated the incidence of bleeding complications after a PRG and its management including transcatheter arterial embolization (TAE). We retrospectively reviewed 574 patients who underwent PRG in our institution between 2000 and 2010. Eight patients (1.4%) had symptoms or signs of upper GI bleeding after PRG. The initial presentation was hematemesis (n = 3), melena (n = 2), hematochezia (n = 2) and bloody drainage through the gastrostomy tube (n = 1). The time interval between PRG placement and detection of bleeding ranged from immediately after to 3 days later (mean: 28 hours). The mean decrease in hemoglobin concentration was 3.69 g/dL (range, 0.9 to 6.8 g/dL). In three patients, bleeding was controlled by transfusion (n = 2) or compression of the gastrostomy site (n = 1). The remaining five patients underwent an angiography because bleeding could not be controlled by transfusion only. In one patient, the bleeding focus was not evident on angiography or endoscopy, and wedge resection including the tube insertion site was performed for hemostasis. The other four patients underwent prophylactic (n = 1) or therapeutic (n = 3) TAEs. In three patients, successful hemostasis was achieved by TAE, whereas the remaining one patient underwent exploration due to persistent bleeding despite TAE. We observed an incidence of upper GI bleeding complicating the PRG of 1.4%. TAE following conservative management appears to be safe and effective for hemostasis.

  1. Cone-Beam Computed Tomography-Guided Percutaneous Radiologic Gastrostomy

    International Nuclear Information System (INIS)

    Moehlenbruch, Markus; Nelles, Michael; Thomas, Daniel; Willinek, Winfried; Gerstner, Andreas; Schild, Hans H.; Wilhelm, Kai

    2010-01-01

    The purpose of this study was to investigate the feasibility of a flat-detector C-arm-guided radiographic technique (cone-beam computed tomography [CBCT]) for percutaneous radiologic gastrostomy (PRG) insertion. Eighteen patients (13 men and 5 women; mean age 62 years) in whom percutaneous endoscopic gastrostomy (PEG) had failed underwent CBCT-guided PRG insertion. PEG failure or unsuitability was caused by upper gastrointestinal tract obstruction in all cases. Indications for gastrostomy were esophageal and head and neck malignancies, respectively. Before the PRG procedure, initial C-arm CBCT scans were acquired. Three- and 2-dimensional soft-tissue reconstructions of the epigastrium region were generated on a dedicated workstation. Subsequently, gastropexy was performed with T-fasteners after CBCT-guided puncture of the stomach bubble, followed by insertion of an 14F balloon-retained catheter through a peel-away introducer. Puncture of the stomach bubble and PRG insertion was technically successful in all patients without alteration of the epigastric region. There was no malpositioning of the tube or other major periprocedural complications. In 2 patients, minor complications occurred during the first 30 days of follow-up (PRG malfunction: n = 1; slight infection: n = 1). Late complications, which were mainly tube disturbances, were observed in 2 patients. The mean follow-up time was 212 days. CBCT-guided PRG is a safe, well-tolerated, and successful method of gastrostomy insertion in patients in whom endoscopic gastrostomy is not feasible. CBCT provides detailed imaging of the soft tissue and surrounding structures of the epigastric region in one diagnostic tour and thus significantly improves the planning of PRG procedures.

  2. Ice Velocity Variations of the Polar Record Glacier (East Antarctica Using a Rotation-Invariant Feature-Tracking Approach

    Directory of Open Access Journals (Sweden)

    Tingting Liu

    2017-12-01

    Full Text Available In this study, the ice velocity changes from 2004 to 2015 of the Polar Record Glacier (PRG in East Antarctica were investigated based on a feature-tracking method using Landsat-7 enhanced thematic mapper plus (ETM+ and Landsat-8 operational land imager (OLI images. The flow field of the PRG curves make it difficult to generate ice velocities in some areas using the traditional normalized cross-correlation (NCC-based feature-tracking method. Therefore, a rotation-invariant parameter from scale-invariant feature transform (SIFT is introduced to build a novel rotation-invariant feature-tracking approach. The validation was performed based on multi-source images and the making earth system data records for use in research environments (MEaSUREs interferometric synthetic aperture radar (InSAR-based Antarctica ice velocity map data set. The results indicate that the proposed method is able to measure the ice velocity in more areas and performs as well as the traditional NCC-based feature-tracking method. The sequential ice velocities obtained present the variations in the PRG during this period. Although the maximum ice velocity of the frontal margin of the PRG and the frontal iceberg reached about 900 m/a and 1000 m/a, respectively, the trend from 2004 to 2015 showed no significant change. Under the interaction of the Polar Times Glacier and the Polarforschung Glacier, both the direction and the displacement of the PRG were influenced. This impact also led to higher velocities in the western areas of the PRG than in the eastern areas. In addition, elevation changes and frontal iceberg calving also impacted the ice velocity of the PRG.

  3. PENGARUH KEDELAI PRODUK REKAYASA GENETIK TERHADAP KADAR MALONALDEHID, AKTIVITAS SUPEROKSIDA DISMUTASE DAN PROFIL DARAH PADA TIKUS PERCOBAAN

    Directory of Open Access Journals (Sweden)

    Dadi Hidayat Maskar

    2015-12-01

    Full Text Available ABSTRACTTempe, a soybean fermentation, has a short shelf life. An effort to extend the shelf life of tempe has been done by making tempe flour. Difference of raw materials which were Genetically Modified Organism (GMO and non-GMO was pressured to cause different impact on human health. Thus, this study was conducted to evaluate the effect of tempe flour that were made from GMO and non-GMO soybean upon malonaldehida (MDA levels,intracellular antioxidant superoxide dismutase (SOD activity in the liver and kidneys of experimental rats, as well as hematological profile. Twenty five Sprague Dawley rats divided into four treatment grups and onecontrol, feeded with tempe from GMO and non-GMO at 10% and 20% concentrations at the period of 90 days.The results showed that rats fed with 10% protein derived from non-GMO soybean flour had lower levelsof MDA in the liver and kidney compared to GMO tempe flour group consisting rations of 10% and 20% protein but, not significantly different from the group protein of 20% non-GMO soybean flour and 10% protein of casein. While the value of liver and kidney SOD activity were not significantly different (p>0,05 between the groups of rats. The results showed that the values obtained were within normal limits. However, the amount of thrombocytes in each treatment had a value that exceeds normal limits. The activity of rat, rat’s metabolism, and amount of feed intake by rats might influenced the result. This experimental study lead to conclude that consuming GMO and non-GMO tempe flour is safe.Keywords: experimental rats, GMO tempe flour, non-GMO tempe flour, hematology, superoxide dismutaseABSTRAKTempe merupakan produk fermentasi kedelai yang mempunyai masa simpan relatif pendek. Upaya untuk meningkatkan masa simpan diantaranya dengan dibuat tepung tempe. Perbedaan bahan baku dari kedelai pangan rekayasa genetik (PRG dan non-PRG menimbulkan kehawatiran terhadap dampak kesehatan bagi manusia. Penelitian ini bertujuan

  4. Packaging Review Guide for Reviewing Safety Analysis Reports for Packagings

    Energy Technology Data Exchange (ETDEWEB)

    DiSabatino, A; Biswas, D; DeMicco, M; Fisher, L E; Hafner, R; Haslam, J; Mok, G; Patel, C; Russell, E

    2007-04-12

    This Packaging Review Guide (PRG) provides guidance for Department of Energy (DOE) review and approval of packagings to transport fissile and Type B quantities of radioactive material. It fulfills, in part, the requirements of DOE Order 460.1B for the Headquarters Certifying Official to establish standards and to provide guidance for the preparation of Safety Analysis Reports for Packagings (SARPs). This PRG is intended for use by the Headquarters Certifying Official and his or her review staff, DOE Secretarial offices, operations/field offices, and applicants for DOE packaging approval. This PRG is generally organized at the section level in a format similar to that recommended in Regulatory Guide 7.9 (RG 7.9). One notable exception is the addition of Section 9 (Quality Assurance), which is not included as a separate chapter in RG 7.9. Within each section, this PRG addresses the technical and regulatory bases for the review, the manner in which the review is accomplished, and findings that are generally applicable for a package that meets the approval standards. This Packaging Review Guide (PRG) provides guidance for DOE review and approval of packagings to transport fissile and Type B quantities of radioactive material. It fulfills, in part, the requirements of DOE O 460.1B for the Headquarters Certifying Official to establish standards and to provide guidance for the preparation of Safety Analysis Reports for Packagings (SARPs). This PRG is intended for use by the Headquarters Certifying Official and his review staff, DOE Secretarial offices, operations/field offices, and applicants for DOE packaging approval. The primary objectives of this PRG are to: (1) Summarize the regulatory requirements for package approval; (2) Describe the technical review procedures by which DOE determines that these requirements have been satisfied; (3) Establish and maintain the quality and uniformity of reviews; (4) Define the base from which to evaluate proposed changes in scope

  5. Elu on väärt riskideski / Juta Üts

    Index Scriptorium Estoniae

    Üts, Juta, 1934-

    2004-01-01

    Tallinna Noorte Naiste ja Noorte Meeste Kristlik Ühing aitab läbi projektide "Terve Eesti laps" ja "Elu on väärt ka riskides" õpetada astma- ja suhkruhaigetele lastele toimetulekut oma haigusega. Projekte tutvustavad Tallinna NNKÜ ja NMKÜ peasekretär Katrin Ohno, Tallinna Kesklinna Lastepolikliiniku päevastatsionaari töötaja Viive Sirge ning endokrinoloog dr. Riina Shor

  6. Kamuflaažmaja / Mihkel Karu

    Index Scriptorium Estoniae

    Karu, Mihkel, 1983-

    2013-01-01

    Oskuslikult mändide vahele sobitatud eramu Tallinna lähedal. Arhitektid Illimar Truverk ja Priit Hamer (Arhitekt11/Agabus, Endjärv & Truverj Arhitektid). Sisearhitektid Külli Salum ja Riina Harik (Saha In). Veel lõplikult teostamata maastikuarhitektuurse lahenduse kavandasid Kätlin Ölluk ja Kadi Markna. Ehitusaeg: 2010-2012. Elamispind: 409/160 m²

  7. Loomingu preemiad

    Index Scriptorium Estoniae

    2002-01-01

    Luuleauhind - Paul-Eerik Rummo (luuletsükkel "Õnnelik"); proosa - Peeter Sauter ("Pätt ja pihiisa"); esseistika - Madis Kõiv ("Nõnda lausus Jaan Kaplinski") ja Lauri Sommer ("Mõnest Uku Masingu kujundatud jõujoonest. Ekstaasi ja teksti suhe"); kriitika - Jan Kaus ("Külluse tekst, teksti küllus" ja "Kuninga vari ja vari-kuninga helk"); tõlkeauhind - Riina Jesmin (Joseph Conradi "Salakuulaja")

  8. Loomingu aastapreemiad selgunud

    Index Scriptorium Estoniae

    2002-01-01

    Luuleauhind - Paul-Eerik Rummo (luuletsükkel "Õnnelik"); proosa - Peeter Sauter ("Pätt ja pihiisa"); esseistika - Madis Kõiv ("Nõnda lausus Jaan Kaplinski") ja Lauri Sommer ("Mõnest Uku Masingu kujundatud jõujoonest. Ekstaasi ja teksti suhe"); kriitika - Jan Kaus ("Külluse tekst, teksti küllus" ja "Kuninga vari ja vari-kuninga helk"); tõlkeauhind - Riina Jesmin (Joseph Conradi "Salakuulaja")

  9. Paremad preemiatega pärjatud / Tiina Kolk

    Index Scriptorium Estoniae

    Kolk, Tiina

    2008-01-01

    Eesti Sisearhitektide Liidu 2007. aasta preemiad pälvisid: Tartu Lotte lasteaia interjöör (sisearhitektid Malle Jürgenson, Krista Lepland, disainerid Sirli Ehari, Tea Tammelaan); Tartu rokibaar Underground (arhitekt Margus Mänd); Tallinna hotell Telegraaf (sisearhitektid Külli Salum, Riina Harik); Sakubü bürooruumid (sisearhitektid Urmo Vaikla, Tüüne-Kristin Vaikla); Andres Labi ja Janno Roosi disainitud valgusti Labak

  10. Ringiratast meie vabariigi pealinnas / Jan Kaus

    Index Scriptorium Estoniae

    Kaus, Jan, 1971-

    2004-01-01

    Esilinastus mängufilm "Täna öösel me ei maga" : stsenaristid Kristian Taska, Jaan Tätte : režissöör Ilmar Taska : operaator Istvan Borbas : produtsent Kristian Taska : peaosades Carmen Kass, Peter Franzen; Maria Avdjushko, Priit Võigemast : Taska Productions. Esilinastus 4. märts 2004. Lisatud Jaan Tätte, Riina Rõõmuse ja Kaur Kenderi kommentaarid.

  11. Edukas äritegevus ja kunst käivad käsikäes / Reinhold Würth ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Würth, Reinhold

    2005-01-01

    Intervjuu suurärimehe ja kunstimetseeni Reinhold Würthiga, kelle kontserni kontori- ja laohoone (arhitekt Priit Kaljapulk, sisekujundaja Piret Mudist) avati 31. VII Assakul. Hoone juurde kuuluv galerii avati Jaan Elkeni koostatud näitusega, mille avamistseremoonia kujundas Riina Vanhanen. R. Würthi kunstikogust, mille põhjal ta avas 1991. a. Künzelsau-Gaisbachis muuseumi. 2001. a. avati Schwäbischis Kunsthalle Würth. Eesti galeriiga seotud plaanidest

  12. Kulinaarne palverännak piki Telliskivi tänavat / Martin Hanson, Ines Haak

    Index Scriptorium Estoniae

    Hanson, Martin, 1984-

    2013-01-01

    Toidukriitik Martin Hanson ja sisearhitekt Ines Haak Tallinna Telliskivi tänavat palistavatest söögipaikadest: restoran Kolm Sibulat (sisearhitektuur: Aivar Mühlbach, omanikud, 2012-2013), bistroo Kukeke (Anni Arro, Riina Eerik, 2011-2012), kohvik Reval (Ville Lausmäe, Kadi Karmann, Peeter Klaas, 2013), restoran F-Hoone (Ville Jehe, Steve Heinlo, 2010), baar Pudel (Raul Tiitus, Tarmo Piirmets, 2012-2013)

  13. Kevadfestival oli metsateemaline

    Index Scriptorium Estoniae

    2006-01-01

    Üritustest 29. maist kuni 1. juunini Türi Kevadfestivali raames: Alo Põldmäe loodusfotode näituse "Muusikaline Neeruti" avamisest 30. mail Türi kultuurimajas, pianisti Kadri-Ann Sumera esinemisest festivali avakontserdil "Metsastseenid" 29. mail Türi kultuurimajas, regilaulude laulmisest Jaak Johansoni ja Riina Roose eestvedamisel ürituse "Ööülikool" raames 30. mail, koomilise laulumängu "Lopi ja Lapi" esietendusest 31. mail Oisu rahvamajas

  14. Hotell "Telegraaf" Tallinnas Vene tänaval = Hotel Telegraaf on Vene Street, Tallinn / Mihkel Karu

    Index Scriptorium Estoniae

    Karu, Mihkel, 1983-

    2007-01-01

    Endise Kommertspanga (ehitatud 1874. a. arhitekt P. Schreiberi projekti järgi N. Thamme juhtimisel) ja hilisema Tallinna Telegraafi hoonesse Vene t. 9 rajatud hotell. Arhitekt: Martin Aunin. Projekteerija: EA Reng AS. Konstruktor: Riho Märtson. Sisekujundajad: Külli Salum, Riina Harik. Projekt: 2004, valmis: 2007. I ja III korruse plaan, 2 värv. välisvaadet, 4 sisevaadet

  15. Hotell Telegraaf = Hotel Telegraaf

    Index Scriptorium Estoniae

    2008-01-01

    Hotelli Telegraaf (Vene 9, Tallinn) sisekujundus, mis pälvis Eesti Sisearhitektide Liidu 2007. a. ajaloolise interjööri preemia. Juurdeehitise arhitekt: Martin Aunin. Sisearhitektid: Külli Salum ja Riina Harik (SAHA IN OÜ). Sisearhitektidest, nende tähtsamad tööd. I ja II korruse plaan, värv. välisvaade, 18 sisevaadet, fotod sisearhitektidest

  16. "Leiutajateküla Lotte" sai toetust Euroopa filmifondilt / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2004-01-01

    Euroopa Nõukogu juures tegutsev Eurimages'i fond määras toetuse Eesti Joonisfilmi täispikale filmile, mille autoriteks on Heiki Ernits, Janno Põldma ja Andrus Kivirähk. Filmi tootjate hulka kuuluvad ka Läti stuudio Rija Films ja Eesti Televisioon. Kommentaariks vastavad küsimustele EFSA peadirektor Martin Aadamsoo, projekti produtsent Riina Sildos ja Eesti Televisiooni juht Ilmar Raag

  17. Saksa esimene saadik : eestlastel on rohkem ühist sakslaste kui soomlastega / Henning von Wistinghausen ; interv. Merit Kopli

    Index Scriptorium Estoniae

    Wistinghausen, Henning von

    2004-01-01

    Saksamaa esimene suursaadik taasiseseisvumise järgses Eestis vastab küsimustele, mis puudutavad Eesti liitumist EL-iga, euroskeptitsismi, Toomas Hendrik Ilvese väidet, et Saksa kantsler Helmut Kohl oli kuni 1997. aastani Balti riikide EL-iga liitumise vastu. Suure probleemina Eestis näeb ta lõhet, mis on tekkinud sissetulekutes ning maa ja linna vahel. Kommenteerib Riina Kionka

  18. Põlvkondade triloogia Von Krahli teatris / Hedi-Liis Toome

    Index Scriptorium Estoniae

    Toome, Hedi-Liis

    2010-01-01

    Von Krahli teatri lavastustest: William Shakespeare "Kuningas Lear", mängib Viljandi Kultuuriakadeemia 8. lend, lavastaja Peeter Jalakas (esietendus 30. jaan. 2010); "The End" - autorid, lavastajad ja näitlejad: Mari Abel, Tiina Tauraite, Riina Maidre, Erki Laur, Taavi Eelmaa, Juhan Ulfsak (esietendus 19. märts 2010); "Mehed lumes" Peter Freucheni jutustuse "Olavi lugu" ainetel lavastanud Mart Koldits ja Kristjan Sarv, kes ka ise mängivad (17. aprill 2010)

  19. Loeme veel! / Kristi Pärn-Valdoja, Katrin Pauts

    Index Scriptorium Estoniae

    Pärn-Valdoja, Kristi, 1970-

    2006-01-01

    TNS Emor väärtushinnangute uuringu RISC 2006 andmetel on igapäevane lugemisharjumus 29 protsendil Eesti naistest ja 20 protsendil meestest. Tallinna abilinnapea Kaia Jäppinen, investeerimistoodete turundusjuht Piret Reinson, KUMU direktor Sirje Helme, laulja Maarja-Liis Ilus ning näitleja Riina Maide kõige enam nende elu ja tegevust mõjutanud raamatutest. Lisa: Millised on Hollywoodi naiste lemmikraamatud?

  20. Validation of kinetic modeling of progesterone release from polymeric membranes

    Directory of Open Access Journals (Sweden)

    Analia Irma Romero

    2018-01-01

    Full Text Available Mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In this paper we validate a novel mathematical model that describes progesterone (Prg controlled release from poly-3-hydroxybutyric acid (PHB membranes. A statistical analysis was conducted to compare the fitting of our model with six different models and the Akaike information criterion (AIC was used to find the equation with best-fit. A simple relation between mass and drug released rate was found, which allows predicting the effect of Prg loads on the release behavior. Our proposed model was the one with minimum AIC value, and therefore it was the one that statistically fitted better the experimental data obtained for all the Prg loads tested. Furthermore, the initial release rate was calculated and therefore, the interface mass transfer coefficient estimated and the equilibrium distribution constant of Prg between the PHB and the release medium was also determined. The results lead us to conclude that our proposed model is the one which best fits the experimental data and can be successfully used to describe Prg drug release in PHB membranes.

  1. Surgical management with intentional replantation on a tooth with palato-radicular groove

    Directory of Open Access Journals (Sweden)

    Jorge Forero-López

    2015-05-01

    Full Text Available A palato-radicular groove (PRG is a developmental anomaly primarily found in the maxillary lateral incisors. It is a potential communication path between the root canal and the periodontium that decreases the survival prognosis of the affected tooth, therefore compromising the stability of the dental structure in the oral cavity. The aim of this case report is to present an original technique where a PRG was treated by means of intracanal disinfection, PRG sealing with glass ionomer, replantation with intentional horizontal 180 degree rotation of the tooth, and an aesthetic veneer placed to provide adequate tooth morphology. The clinical and biological benefits of this novel technique are presented and discussed.

  2. Why and how did Israel adopt activity-based hospital payment? The Procedure-Related Group incremental reform.

    Science.gov (United States)

    Brammli-Greenberg, Shuli; Waitzberg, Ruth; Perman, Vadim; Gamzu, Ronni

    2016-10-01

    Historically, Israel paid its non-profit hospitals on a perdiem (PD) basis. Recently, like other OECD countries, Israel has moved to activity-based payments. While most countries have adopted a diagnostic related group (DRG) payment system, Israel has chosen a Procedure-Related Group (PRG) system. This differs from the DRG system because it classifies patients by procedure rather than diagnosis. In Israel, the PRG system was found to be more feasible given the lack of data and information needed in the DRG classification system. The Ministry of Health (MoH) chose a payment scheme that depends only on inhouse creation of PRG codes and costing, thus avoiding dependence on hospital data. The PRG tariffs are priced by a joint Health and Finance Ministry commission and updated periodically. Moreover, PRGs are believed to achieve the same main efficiency objectives as DRGs: increasing the volume of activity, shortening unnecessary hospitalization days, and reducing the gaps between the costs and prices of activities. The PRG system is being adopted through an incremental reform that started in 2002 and was accelerated in 2010. The Israeli MoH involved the main players in the hospital market in the consolidation of this potentially controversial reform in order to avoid opposition. The reform was implemented incrementally in order to preserve the balance of resource allocation and overall expenditures of the system, thus becoming budget neutral. Yet, as long as gaps remain between marginal costs and prices of procedures, PRGs will not attain all their objectives. Moreover, it is still crucial to refine PRG rates to reflect the severity of cases, in order to tackle incentives for selection of patients within each procedure. Copyright © 2016 The Author(s). Published by Elsevier Ireland Ltd.. All rights reserved.

  3. Percutaneous Gastrostomy in Patients Who Fail or Are Unsuitable for Endoscopic Gastrostomy

    International Nuclear Information System (INIS)

    Thornton, Frank J.; Varghese, Jose C.; Haslam, Philip J.; McGrath, Frank P.; Keeling, Frank; Lee, Michael J.

    2000-01-01

    Purpose: Percutaneous endoscopic gastrostomy (PEG) is not possible or fails in some patients. We aimed to categorize the reasons for PEG failure, to study the success of percutaneous radiologic gastrostomy (PRG) in these patients, and to highlight the associated technical difficulties and complications.Methods: Forty-two patients (28 men, 14 women; mean age 60 years, range 18-93 years) in whom PEG failed or was not possible, underwent PRG. PEG failure or unsuitability was due to upper gastrointestinal tract obstruction or other pathology precluding PEG in 15 of the 42 patients, suboptimal transillumination in 22 of 42 patients, and advanced cardiorespiratory decompensation precluding endoscopy in five of 42 patients. T-fastener gastropexy was used in all patients and 14-18 Fr catheters were inserted.Results: PRG was successful in 41 of 42 patients (98%). CT guidance was required in four patients with altered upper gastrointestinal anatomy. PRG failed in one patient despite CT guidance. In the 16 patients with high subcostal stomachs who failed PEG because of inadequate transillumination, intercostal tube placement was required in three and cephalad angulation under the costal margin in six patients. Major complications included inadvertent placement of the tube in the peritoneal cavity. There was one case of hemorrhage at the gastrostomy site requiring transfusion and one case of superficial gastrostomy site infection requiring tube removal. Minor complications included superficial wound infection in six patients, successfully treated with routine wound toilette.Conclusion: We conclude that PRG is a safe, well-tolerated and successful method of gastrostomy and gastrojejunostomy insertion in the technically difficult group of patients who have undergone an unsuccessful PEG. In many such cases optimal clinical evaluation will suggest primary referral for PRG as the preferred option

  4. Getting a grip on problem gambling: what can neuroscience tell us?

    NARCIS (Netherlands)

    Goudriaan, Anna E.; Yücel, Murat; van Holst, Ruth J.

    2014-01-01

    In problem gamblers, diminished cognitive control and increased impulsivity is present compared to healthy controls. Moreover, impulsivity has been found to be a vulnerability marker for the development of pathological gambling (PG) and problem gambling (PrG) and to be a predictor of relapse. In

  5. Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study

    NARCIS (Netherlands)

    Goudriaan, A.E.; de Ruiter, M.B.; van den Brink, W.; Oosterlaan, J.; Veltman, D.J.

    2010-01-01

    Abnormal cue reactivity is a central characteristic of addiction, associated with increased activity in motivation, attention and memory related brain circuits. In this neuroimaging study, cue reactivity in problem gamblers (PRG) was compared with cue reactivity in heavy smokers (HSM) and healthy

  6. Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission.

    Science.gov (United States)

    Unichenko, Petr; Kirischuk, Sergei; Yang, Jenq-Wei; Baumgart, Jan; Roskoden, Thomas; Schneider, Patrick; Sommer, Angela; Horta, Guilherme; Radyushkin, Konstantin; Nitsch, Robert; Vogt, Johannes; Luhmann, Heiko J

    2016-07-01

    Plasticity-related gene-1 (PRG-1) is a brain-specific protein that modulates glutamatergic synaptic transmission. Here we investigated the functional role of PRG-1 in adolescent and adult mouse barrel cortex both in vitro and in vivo. Compared with wild-type (WT) animals, PRG-1-deficient (KO) mice showed specific behavioral deficits in tests assessing sensorimotor integration and whisker-based sensory discrimination as shown in the beam balance/walking test and sandpaper tactile discrimination test, respectively. At P25-31, spontaneous network activity in the barrel cortex in vivo was higher in KO mice compared with WT littermates, but not at P16-19. At P16-19, sensory evoked cortical responses in vivo elicited by single whisker stimulation were comparable in KO and WT mice. In contrast, at P25-31 evoked responses were smaller in amplitude and longer in duration in WT animals, whereas KO mice revealed no such developmental changes. In thalamocortical slices from KO mice, spontaneous activity was increased already at P16-19, and glutamatergic thalamocortical inputs to Layer 4 spiny stellate neurons were potentiated. We conclude that genetic ablation of PRG-1 modulates already at P16-19 spontaneous and evoked excitability of the barrel cortex, including enhancement of thalamocortical glutamatergic inputs to Layer 4, which distorts sensory processing in adulthood. © The Author 2016. Published by Oxford University Press.

  7. Studies on the increased heat effect within the rubber tree rows of man-made rubber-tea community

    International Nuclear Information System (INIS)

    Ma Youxin

    1994-01-01

    Differences in the various components of thermal balance and the microclimatic factors within lower layers of rubber tree rows between a man-made rubber-tea community(RTC)and a pure rubber garden(PRG)in the coldest month were studied in Xishuangbanna,Yun-nan province

  8. Biota Modeling in EPA's Preliminary Remediation Goal and Dose Compliance Concentration Calculators for Use in EPA Superfund Risk Assessment: Explanation of Intake Rate Derivation, Transfer Factor Compilation, and Mass Loading Factor Sources

    Energy Technology Data Exchange (ETDEWEB)

    Manning, Karessa L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dolislager, Fredrick G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bellamy, Michael B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-11-01

    The Preliminary Remediation Goal (PRG) and Dose Compliance Concentration (DCC) calculators are screening level tools that set forth Environmental Protection Agency's (EPA) recommended approaches, based upon currently available information with respect to risk assessment, for response actions at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites, commonly known as Superfund. The screening levels derived by the PRG and DCC calculators are used to identify isotopes contributing the highest risk and dose as well as establish preliminary remediation goals. Each calculator has a residential gardening scenario and subsistence farmer exposure scenarios that require modeling of the transfer of contaminants from soil and water into various types of biota (crops and animal products). New publications of human intake rates of biota; farm animal intakes of water, soil, and fodder; and soil to plant interactions require updates be implemented into the PRG and DCC exposure scenarios. Recent improvements have been made in the biota modeling for these calculators, including newly derived biota intake rates, more comprehensive soil mass loading factors (MLFs), and more comprehensive soil to tissue transfer factors (TFs) for animals and soil to plant transfer factors (BV's). New biota have been added in both the produce and animal products categories that greatly improve the accuracy and utility of the PRG and DCC calculators and encompass greater geographic diversity on a national and international scale.

  9. High CO2 triggers preferential root growth of Arabidopsis thaliana via two distinct systems under low pH and low N stresses.

    Science.gov (United States)

    Hachiya, Takushi; Sugiura, Daisuke; Kojima, Mikiko; Sato, Shigeru; Yanagisawa, Shuichi; Sakakibara, Hitoshi; Terashima, Ichiro; Noguchi, Ko

    2014-02-01

    Biomass allocation between shoots and roots is an important strategy used by plants to optimize growth in various environments. Root to shoot mass ratios typically increase in response to high CO2, a trend particularly evident under abiotic stress. We investigated this preferential root growth (PRG) in Arabidopsis thaliana plants cultivated under low pH/high CO2 or low nitrogen (N)/high CO2 conditions. Previous studies have suggested that changes in plant hormone, carbon (C) and N status may be related to PRG. We therefore examined the mechanisms underlying PRG by genetically modifying cytokinin (CK) levels, C and N status, and sugar signaling, performing sugar application experiments and determining primary metabolites, plant hormones and expression of related genes. Both low pH/high CO2 and low N/high CO2 stresses induced increases in lateral root (LR) number and led to high C/N ratios; however, under low pH/high CO2 conditions, large quantities of C were accumulated, whereas under low N/high CO2 conditions, N was severely depleted. Analyses of a CK-deficient mutant and a starchless mutant, in conjunction with sugar application experiments, revealed that these stresses induce PRG via different mechanisms. Metabolite and hormone profile analysis indicated that under low pH/high CO2 conditions, excess C accumulation may enhance LR number through the dual actions of increased auxin and decreased CKs.

  10. [Experimental research on the effects of different activators on the formation of platelet-rich gel and the release of bioactive substances in human platelet-rich plasma].

    Science.gov (United States)

    Yang, Y; Zhang, W; Cheng, B

    2017-01-20

    Objective: To explore the effects of calcium gluconate and thrombin on the formation of platelet-rich gel (PRG) and the release of bioactive substances in human platelet-rich plasma (PRP) and the clinical significance. Methods: Six healthy blood donors who met the inclusion criteria were recruited in our unit from May to August in 2016. Platelet samples of each donor were collected for preparation of PRP. (1) PRP in the volume of 10 mL was collected from each donor and divided into thrombin activation group (TA, added with 0.5 mL thrombin solution in dose of 100 U/mL) and calcium gluconate activation group (CGA, added with 0.5 mL calcium gluconate solution in dose of 100 g/L) according to the random number table, with 5 mL PRP in each group. Then the PRP of the two groups was activated in water bath at 37 ℃ for 1 h. The formation time of PRG was recorded, and the formation situation of PRG was observed within 1 hour of activation. After being activated for 1 h, one part of PRG was collected to observe the distribution of fibrous protein with HE staining, and another part of PRG was collected to observe platelet ultrastructure under transmission electron microscope (TEM). After being activated for 1 h, the supernatant was collected to determine the content of transforming growth factor β(1, )platelet-derived growth factor BB (PDGF-BB), vascular endothelial growth factor, basic fibroblast growth factor (bFGF), epidermal growth factor, and insulin-like growth factorⅠby enzyme-linked immunosorbent assay. (2) Another 10 mL PRP from each donor was collected and grouped as above, and the platelet suspension was obtained after two times of centrifugation and resuspension with phosphate buffered saline, respectively. And then they were treated with corresponding activator for 1 h as that in experiment (1). Nanoparticle tracking analyzer was used to detect the concentrations of microvesicles with different diameters and total microvesicles derived from platelet. Data

  11. Attachment of Salmonella spp. to pork meat

    DEFF Research Database (Denmark)

    Hansen, Trine; Riber, Leise; Löfström, Charlotta

    2011-01-01

    Five strains of Salmonella, one wildtype and four knock-out mutants (the prg, flhDC, yhjH and fliC genes) were investigated based on their probability to attach and subsequently detach from a surface of pork fillet. The attachment followed by detachment was measured and modelled for two different...

  12. Dimensionality Reduction in Big Data with Nonnegative Matrix Factorization

    Science.gov (United States)

    2017-06-20

    Multiplicative Update Rule(MUR), Projected Gradient Meth- ods (PrG), Block Principal Pivoting method(BlP), Fast Active-set-like method(AcS), Fast...16], one of the robust ensemble meth- ods , to classify the testing datasets. The proposed algorithm outperforms the other algorithms and PCA over all

  13. Identifikasi Gen Transgenik pada Produk Susu Bubuk Kedelai dan Susu Formula Soya dengan Metode PCR (Polymerase Chain Reaction

    Directory of Open Access Journals (Sweden)

    Agustin Krisna Wardani

    2018-01-01

      Kebutuhan kedelai yang mencapai 2,2 juta ton/tahun memaksa Indonesia mengimpor sebanyak 1,62 juta ton. Sebagian besar kedelai impor berupa kedelai transgenik. Dengan munculnya kedelai transgenik di Indonesia, perlu adanya pelabelan Produk Rekayasa Genetika (PRG untuk memenuhi hak-hak konsumen. Teknik yang dilakukan untuk mendeteksi PRG salah satunya menggunakan metode PCR. Penelitian ini bertujuan untuk mengetahui ada tidaknya gen transgenik pada produk susu bubuk kedelai dan formula soya, sehingga produk dapat digolongkan sebagai PRG atau tidak. Selain itu juga bertujuan untuk mengetahui suhu annealing optimum pada primer yang digunakan. Hasil penelitian didapatkan suhu annealing optimum primer CaMV 35S promotor adalah 60oC. Sedangkan untuk primer gen EPSPS-CP4 suhu annealing optimumnya 59oC. Untuk primer NOS terminator suhu annealing optimum tidak ditemukan. Dari amplifikasi DNA sampel, 6 sampel susu bubuk kedelai dan 5 sampel formula soya terdapat sisipan gen EPSPS-CP4 dan gen Promotor CaMV 35S. Dengan demikian 11 sampel tersebut dapat dikatakan sebagai PRG.   Kata kunci: Produk rekayasa genetika; PCR; formula soya; susu kedelai bubuk; kedelai transgenik

  14. Treatment of an intrabony osseous lesion associated with a palatoradicular groove

    Directory of Open Access Journals (Sweden)

    A Suchetha

    2012-01-01

    Full Text Available Various root developmental anomalies like palatoradicular groove (PRG have been associated with worsening of periodontal condition. The aim of the present case report is to describe the regenerative surgical treatment of periodontal and osseous lesion associated with the subgingival extension of PRG. A 23-year-old female patient reported with pain in upper incisor teeth region. On clinical and radiological examination, a deep endosseous defect was found distal to maxillary right lateral incisor that was etiologically associated with the presence of a PRG. Treatment procedures consisted of: Regenerative periodontal therapy using Guided tissue regeneration (GTR and hydroxyapatite (HA bone graft and 2 flattening of the radicular portion of the palatal groove. The clinical examination at 1 year revealed shallow residual probing depth (3 mm and no increase in gingival recession. The radiographic examination showed reduction in the radiolucency suggesting bone fill. A PRG may serve as a pathway for the development of a periodontal osseous defect. The combination of GTR and HA may be clinically and radiographically efficacious in the treatment of such a defect.

  15. Biota Modeling in EPA's Preliminary Remediation Goal and Dose Compliance Concentration Calculators for Use in EPA Superfund Risk Assessment: Explanation of Intake Rate Derivation, Transfer Factor Compilation, and Mass Loading Factor Sources

    International Nuclear Information System (INIS)

    Manning, Karessa L.; Dolislager, Fredrick G.; Bellamy, Michael B.

    2016-01-01

    The Preliminary Remediation Goal (PRG) and Dose Compliance Concentration (DCC) calculators are screening level tools that set forth Environmental Protection Agency's (EPA) recommended approaches, based upon currently available information with respect to risk assessment, for response actions at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites, commonly known as Superfund. The screening levels derived by the PRG and DCC calculators are used to identify isotopes contributing the highest risk and dose as well as establish preliminary remediation goals. Each calculator has a residential gardening scenario and subsistence farmer exposure scenarios that require modeling of the transfer of contaminants from soil and water into various types of biota (crops and animal products). New publications of human intake rates of biota; farm animal intakes of water, soil, and fodder; and soil to plant interactions require updates be implemented into the PRG and DCC exposure scenarios. Recent improvements have been made in the biota modeling for these calculators, including newly derived biota intake rates, more comprehensive soil mass loading factors (MLFs), and more comprehensive soil to tissue transfer factors (TFs) for animals and soil to plant transfer factors (BV's). New biota have been added in both the produce and animal products categories that greatly improve the accuracy and utility of the PRG and DCC calculators and encompass greater geographic diversity on a national and international scale.

  16. The Animal Pathogen-Like Type III Secretion System is Required for the Intracellular Survival of Burkholderia mallei within J774.2 Macrophages

    Science.gov (United States)

    2006-03-30

    for B. mallei are horses, donkeys, and mules (solipeds), but other animals, including mice, hamsters, guinea pigs, monkeys , lions, and dogs, are...Spa/Prg and Shigella Ipa/Mxi/Spa TTS networks, are important for in vitro and in vivo survival of these pathogenic Burkholderia species (9–12, 14, 15

  17. 3C 220.3: A Radio Galaxy Lensing a Submillimeter Galaxy

    NARCIS (Netherlands)

    Haas, Martin; Leipski, Christian; Barthel, Peter; Wilkes, Belinda J.; Vegetti, Simona; Bussmann, R. Shane; Willner, S. P.; Westhues, Christian; Ashby, Matthew L. N.; Chini, Rolf; Clements, David L.; Fassnacht, Christopher D.; Horesh, Assaf; Klaas, Ulrich; Koopmans, Léon V. E.; Kuraszkiewicz, Joanna; Lagattuta, David J.; Meisenheimer, Klaus; Stern, Daniel; Wylezalek, Dominika

    2014-01-01

    Herschel Space Observatory photometry and extensive multiwavelength follow-up have revealed that the powerful radio galaxy (PRG) 3C 220.3 at z = 0.685 acts as a gravitational lens for a background submillimeter galaxy (SMG) at z = 2.221. At an observed wavelength of 1 mm, the SMG is lensed into

  18. Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel.

    Science.gov (United States)

    Giraldo, Carlos E; López, Catalina; Álvarez, María E; Samudio, Ismael J; Prades, Marta; Carmona, Jorge U

    2013-02-12

    There is no information on the effects of the breed, gender and age on the cellular content and growth factor (GF) release from equine pure-platelet rich plasma (P-PRP) and pure-platelet rich gel (P-PRG). The objectives of this study were: 1) to compare the cellular composition of P-PRP with whole blood and platelet poor plasma (PPP); 2) to compare the concentration of transforming GF beta 1 (TGF-β1) and platelet derived GF isoform BB (PDGF-BB) between P-PRP treated with non-ionic detergent (P-PRP+NID), P-PRG (activated with calcium gluconate -CG-), PPP+NID, PPP gel (PPG), and plasma and; 3) to evaluate and to correlate the effect of the breed, gender and age on the cellular and GF concentration for each blood component. Forty adult horses, 20 Argentinean Creole Horses (ACH) and, 20 Colombian Creole Horses (CCH) were included. Data were analyzed by parametric (i.e.: t-test, one way ANOVA) and non parametric (Kruskal-Wallis test, Wilcoxon test) tests. Correlation analysis was also performed by using the Spearman and Pearson tests. A p ≤ 0.05 was set as significant for all tests. All the blood components were compared for platelet (PLT), leukocyte (WBC), TGF-β1 and PDGF-BB concentrations. The effect of the breed, gender and age on these variables was analyzed. A P ≤ 0.05 was accepted as significant for all the tests. PLT counts were 1.8 and 0.6 times higher in P-PRP than in whole blood and PPP, respectively; WBC counts were 0.5 and 0.1 times lower in P-PRP, in comparison with whole blood and PPP, respectively. TGF-β1 and PDGF-BB concentrations were 2.3 and 262 times higher, respectively, in P-PRG than in plasma, and 0.59 and 0.48 times higher, respectively, in P-PRG than in PPG. P-PRG derived from CCH females or young horses presented significantly (P < 0.001) higher PDGF-BB concentrations than P-PRG derived from ACH males or older horses. Our results indicated that P-PRP obtained by a manual method was affected by intrinsic factors such as the breed

  19. Packaging review guide for reviewing safety analysis reports for packagings: Revision 0

    International Nuclear Information System (INIS)

    Fischer, L.E.; Chou, C.K.; Lloyd, W.R.; Mount, M.E.; Nelson, T.A.; Schwartz, M.W.; Witte, M.C.

    1987-09-01

    The Department of Energy (DOE) has established procedures for obtaining certification of packagings used by DOE and its contractors for the transport of radioactive materials. These certification review policies and procedures are established to ensure that DOE packaging designs and operations meet safety criteria at least equivalent to the standards prescribed by the Nuclear Regulatory Commission (NRC) certification process for packaging. The Packaging Review Guide (PRG) is not a DOE order, but has been prepared as guidance for the Packaging Certification Staff (PCS) under the Certifying Official, Office of Security Evaluations, or designated representatives. The principal purpose of the PRG is to assure the quality and uniformity of PCS reviews, and to present a well-defined base from which to evaluate proposed changes in the scope and requirements of reviews. The PRG also sets forth solutions and approaches determined to be acceptable in the past by the PCS in dealing with a specific safety issue or safety-related design area. These solutions and approaches are presented in this form so that reviewers can take consistent and well-understood positions as the same safety issues arise in future cases. An applicant submitting a SARP does not have to follow the solutions or approaches presented in the PRG. However, applicants should recognize that the PCS has spent substantial time and effort in reviewing and developing their positions for the issues. A corresponding amount of time and effort will probably be required to review and accept new or different solutions and approaches. Finally, it is also a purpose of the PRG to make information about DOE certification policy and procedures widely available to DOE field offices, DOE contractors, federal agencies, and interested members of the public. 7 refs., 15 figs., 14 tabs

  20. Getting a grip on problem gambling: What can neuroscience tell us?

    Directory of Open Access Journals (Sweden)

    Anna E Goudriaan

    2014-05-01

    Full Text Available In problem gamblers, diminished cognitive control and increased impulsivity is present compared to healthy controls. Moreover, impulsivity has been found to be a vulnerability marker for the development of pathological gambling (PG and problem gambling (PrG and to be a predictor of relapse. In this review, the most recent findings on functioning of the brain circuitry relating to impulsivity and cognitive control in PG and PrG are discussed. Diminished functioning of several prefrontal areas and of the anterior cingulate cortex indicate that cognitive-control related brain circuitry functions are diminished in PG and PrG compared to healthy controls. From the available cue reactivity studies on PG and PrG, increased responsiveness towards gambling stimuli in fronto-striatal reward circuitry and brain areas related to attentional processing is present compared to healthy controls. At this point it is unresolved whether PG is associated with hyper- or hypo-activity in the reward circuitry in response to monetary cues. More research is needed to elucidate the complex interactions for reward responsivity in different stages of gambling and across different types of reward. Conflicting findings from basic neuroscience studies are integrated in the context of recent neurobiological addiction models. Neuroscience studies on the interface between cognitive control and motivational processing are discussed in light of current addiction theories.Clinical implications: we suggest that innovation in PG therapy should focus on improvement of dysfunctional cognitive control and/or motivational functions. The implementation of novel treatment methods like neuromodulation, cognitive training and pharmacological interventions as add-on therapies to standard treatment in PG and PrG, in combination with the study of their effects on brain-behavior mechanisms could prove an important clinical step forward towards personalizing and improving treatment results in PG.

  1. Clinical application of percutaneous gastrostomy and gastrojejunostomy under fluoroscopic guidance

    International Nuclear Information System (INIS)

    Zhou Jianping; Wang Zhongmin; Liu Tao; Chen Kemin; Gong Ju; Zheng Yunfeng; Chen Zhijin; Shen Jieyun

    2011-01-01

    Objective: To evaluate the safety and effectiveness of percutaneous gastrostomy (PRG) and gastrojejunostomy (PRGJ) under fluoroscopic guidance, and to discuss its technical manipulation, the indications and contraindications as well as the complications. Methods: During the period from May 2002 to June 2010 in authors' hospital fluoroscopically-guided PRG or PRGJ was carried out in 40 patients. The clinical data were retrospectively analyzed. With Seldinger technique and under fluoroscopic guidance, a 14 F radiopaque gastrostomy or gastrojejunostomy feeding catheter was successfully placed. The indications, operation procedures, clinical success rate, procedure-related complications, and tube indwelling time, etc. were discussed and analyzed. Results: PRG was conducted in 30 patients. The reasons for performing PRG included neurologic disease (n=13), recurrent aspiration pneumonia (n=6), gastroesophageal reflux due to disfunction of gastrointestinal tract (n=3), subtotal gastrectomy (n=2), esophagomediastinal fistula (n=1) and esophageal carcinoma (n=5). PRGJ was carried out in 10 patients. The disorders included bulbar paralysis (n=3), malignant duodenal obstruction (n=4) and previous gastrostomy-related complications (n=3). Two anchors were used in all patients receiving PRG or PRGJ. Clinical success was achieved in all study patients. No procedure-related or severe complications occurred. Minor complications were observed in four patients (10%), which included local soft tissue infection (n=1), severe puncture site pain (n=1), gastrostomy tube dislodgement (n=1) and obstruction of gastrojejunostomy tube (n=1). During the follow-up period, no aggravation of gastroesophageal reflux or aspiration pneumonia was observed in all patients. The tube indwelling time was 115 to 585 days (mean of 150 days) after tube placement. Conclusion: Fluoroscopically-guided percutaneous gastrostomy or gastrojejunostomy is a safe, simple and minimally-invasive technique. This

  2. Estonian arts and crafts still alive / Jana Belugina

    Index Scriptorium Estoniae

    Belugina, Jana

    2008-01-01

    Lühidalt eesti käsitöö ajaloost. Rahvarõivad ja neid kandvad nukud moodustavad siiani suurima osa eesti käsitöö toodetest. Platsiveere Meistrid (Pikk 15) müüb rahvarõivaid, mis on valmistatud sama tehnoloogiaga, mida kasutati sajandeid tagasi. Käsitööesemeid kogub ja säilitab Eesti Rahva Muuseum. 1929. a. loodud Eesti Rahvakunsti ja Käsitöö Liidust, Eesti Käsitöö Majast (Pikk 22), kus asub ka tekstiilikunstnik Riina Tombergi töötuba

  3. ESL aastapreemia 2007 žürii koosoleku protokoll : 7. aprill 2008 = Estonian Society of Interior Architects annual award 2007 : official minutes of the meeting of the jury : 7 April 2008

    Index Scriptorium Estoniae

    2008-01-01

    2007. a. ühiskondliku interjööri preemia: Tea Tammelaan, Malle Jürgenson, Krista Lepland (Lotte lasteaed), ajaloolise interjööri preemia: Külli Salum, Riina Harik (hotell Telegraaf), büroointerjööri preemia: Urmo Vaikla, Tüüne-Kristin Vaikla (Sakubü büroo), publitsistika preemia: Karen Jagodin, Tiit Jürna (näitusekataloog "Tamm ja Asi", eripreemia: Margus Mänd (klubi Underground). Žürii koosseis

  4. Kuidas ühiskondlikus leppes lubatud hea tuntavaks tehakse? / Jaak Aaviksoo, Jüri Tamm, Kaul Nurm...[jt.

    Index Scriptorium Estoniae

    2003-01-01

    Küsimusele "missugune oleks nende panus ja plaan esimese aasta jooksul ühiskondlikus leppes fikseeritud eesmärkide saavutamiseks" vastavad Tartu Ülikooli rektor Jaak Aaviksoo, EOK asepresident Jüri Tamm, Eestimaa Talupidajate Keskliidu peadirektor Kaul Nurm, Eesti Kirikute Nõukogu täitevsekretär Eerik Jõks, Eesti Ühistegelise Liidu juhatuse esimees Urmas Laht, Eesti Väike- ja Keskettevõtjate Assotsiatsiooni juhataja Riina Danilson ning Reformierakonna pressinõunik Peep Lillemägi. Samas ka karikatuur

  5. Konserthuset Göteborg - 21. oktober 1995 kl. 15.00 Stora Salen. I avslutning till Estival 95 Estniska Kulturdagar i Göteborg : [kontserdi kava

    Index Scriptorium Estoniae

    1995-01-01

    Erkki-Sven Tüür: Insula deserta für strakorkester W. A. Mozart: vesperae solennes de confessore K 339; Eduard Tubin: Piano concertino; L. v. Beethoven: Fantasi c-moll för piano, kör och orkester, op. 80. Göteborger Symphoniker, dirigent Neeme Järvi. Solister: Vardo Rumessen, piano; Kaia Urb, sopran; Riina Airenne, mezzosopran; Mati Kõrts, tenor; Uku Joller, bas. Estniska Gosskören, Venno Laul. Esinejate lühitutvustus

  6. Kevadfestival pakub põnevaid elamusi / Ireen Lill

    Index Scriptorium Estoniae

    Lill, Ireen

    2008-01-01

    Üritustest 29. maist kuni 1. juunini toimuva Türi Kevadfestivali raames: koomilise laulumängu "Lopi ja Lapi" esietendus 31. mail Oisu rahvamajas (autoriteks kirjanik Leelo Tungal ja helilooja Tõnis Kaumann), Kadri-Ann Sumera kontsert pealkirjaga "Metsastseenid" 29. mail, Alo Põldmäe loodusfotode näituse "Muusikaline Neeruti" avamine, ansambli Svetilen kontsert 30. mail Türi kirikus, regilaulude laulmine Jaak Johansoni ja Riina Roose eestvedamisel ürituse "Ööülikool" raames 30. mail, festivali lõppkontsert Türi kirikus 1. juunil (esineb organist Ulla Krigul)

  7. Kevadfestival kutsub metsa ja kontserdisaali / Iren Lill

    Index Scriptorium Estoniae

    Lill, Iren

    2008-01-01

    Üritustest 29. maist kuni 1. juunini toimuva Türi Kevadfestivali raames: koomilise laulumängu "Lopi ja Lapi" esietendus 31. mail Oisu rahvamajas (autoriteks kirjanik Leelo Tungal ja helilooja Tõnis Kaumann), Kadri-Ann Sumera kontsert pealkirjaga "Metsastseenid" 29. mail, Alo Põldmäe loodusfotode näituse "Muusikaline Neeruti" avamine, ansambli Svetilen kontsert 30. mail Türi kirikus, regilaulude laulmine Jaak Johansoni ja Riina Roose eestvedamisel ürituse "Ööülikool" raames 30. mail, festivali lõppkontsert Türi kirikus 1. juunil (esineb organist Ulla Krigul)

  8. Milliseid erialaseid teadmisi ja oskusi olete kasutanud oma praeguses ametis? : vastavad infoteaduse eriala vilistlased / interv. Hela Ojasaar, Margot Mahlapuu

    Index Scriptorium Estoniae

    2005-01-01

    Vastavad: EV Presidendi Kantselei direktori asetäitja, üldosakonna juhataja Riina Roomet, Mahtra Talurahvamuuseumi direktor Tiia-Helle Schmitte, EBS-i raamatukogu juhataja Eda Pihu, Euroopa Liidu asjade komisjoni nõunik (Riigikogu) Külli Kask, Kultuuriministeeriumi raamatukogunõunik Meeli Veskus, Võrumaa Keskraamatukogu direktor Inga Kuljus, Lääne Maakonna Keskraamatukogu direktor Ilme Sepp, Riigiarhiivi direktor Marge Tiidus, kirjastuse Pilgrim juht Tiina Ristimets, Tallinna Keskraamatukogu direktor Kaie Holm, Eesti ENIC/NARIC Keskuse infospetsialist Liia Tüür, Eesti Rahvusraamatukogu direktor Tiiu Valm, Tartu Ülikooli Raamatukogu teenindusdirektor Mare-Nelli Ilus, Viljandi Kultuuriakadeemia raamatukogunduse ja infoteaduste osakonna juhataja Ilmar Vaaro

  9. Analysis of Patients' X-ray Exposure in 146 Percutaneous Radiologic Gastrostomies.

    Science.gov (United States)

    Petersen, Tim-Ole; Reinhardt, Martin; Fuchs, Jochen; Gosch, Dieter; Surov, Alexey; Stumpp, Patrick; Kahn, Thomas; Moche, Michael

    2017-09-01

    Purpose  Analysis of patient´s X-ray exposure during percutaneous radiologic gastrostomies (PRG) in a larger population. Materials and Methods  Data of primary successful PRG-procedures, performed between 2004 and 2015 in 146 patients, were analyzed regarding the exposition to X-ray. Dose-area-product (DAP), dose-length-product (DLP) respectively, and fluoroscopy time (FT) were correlated with the used x-ray systems (Flatpanel Detector (FD) vs. Image Itensifier (BV)) and the necessity for periprocedural placement of a nasogastric tube. Additionally, the effective X-ray dose for PRG placement using fluoroscopy (DL), computed tomography (CT), and cone beam CT (CBCT) was estimated using a conversion factor. Results  The median DFP of PRG-placements under fluoroscopy was 163 cGy*cm 2 (flat panel detector systems: 155 cGy*cm 2 ; X-ray image intensifier: 175 cGy*cm 2 ). The median DLZ was 2.2 min. Intraprocedural placement of a naso- or orogastric probe (n = 68) resulted in a significant prolongation of the median DLZ to 2.5 min versus 2 min in patients with an already existing probe. In addition, dose values were analyzed in smaller samples of patients in which the PRG was placed under CBCT (n = 7, median DFP = 2635 cGy*cm 2 ), or using CT (n = 4, median DLP = 657 mGy*cm). Estimates of the median DFP and DLP showed effective doses of 0.3 mSv for DL-assisted placements (flat panel detector 0.3 mSv, X-ray image converter 0.4 mSv), 7.9 mSv using a CBCT - flat detector, and 9.9 mSv using CT. This corresponds to a factor 26 of DL versus CBCT, or a factor 33 of DL versus CT. Conclusion  In order to minimize X-ray exposure during PRG-procedures for patients and staff, fluoroscopically-guided interventions should employ flat detector systems with short transmittance sequences in low dose mode and with slow image frequency. Series recordings can be dispensed with. The intraprocedural placement of a naso- or orogastric probe

  10. Analysis of patients' X-ray exposure in 146 percutaneous radiologic gastrostomies; Analyse der Strahlenexposition fuer Patienten bei 146 perkutanen radiologischen Gastrostomien

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, Tim-Ole; Reinhardt, Martin; Fuchs, Jochen; Gosch, Dieter; Surov, Alexey; Stumpp, Patrick; Kahn, Thomas; Moche, Michael [Univ. Hospital Leipzig (Germany). Dept. of Diagnostic and Interventional Radiology

    2017-09-15

    Analysis of patient's X-ray exposure during percutaneous radiologic gastrostomies (PRG) in a larger population. Data of primary successful PRG-procedures, performed between 2004 and 2015 in 146 patients, were analyzed regarding the exposition to X-ray. Dose-area-product (DAP), dose-length-product (DLP) respectively, and fluoroscopy time (FT) were correlated with the used x-ray systems (Flatpanel Detector (FD) vs. Image Itensifier (BV)) and the necessity for periprocedural placement of a nasogastric tube. Additionally, the effective X-ray dose for PRG placement using fluoroscopy (DL), computed tomography (CT), and cone beam CT (CBCT) was estimated using a conversion factor. The median DFP of PRG-placements under fluoroscopy was 163 cGy{sup *}cm{sup 2} (flat panel detector systems: 155 cGy{sup *}cm{sup 2}; X-ray image intensifier: 175 cGy{sup *}cm{sup 2}). The median DLZ was 2.2min. Intraprocedural placement of a naso- or orogastric probe (n=68) resulted in a significant prolongation of the median DLZ to 2.5min versus 2min in patients with an already existing probe. In addition, dose values were analyzed in smaller samples of patients in which the PRG was placed under CBCT (n=7, median DFP=2635 cGy{sup *}cm{sup 2}), or using CT (n=4, median DLP=657mGy{sup *}cm). Estimates of the median DFP and DLP showed effective doses of 0.3mSv for DL-assisted placements (flat panel detector 0.3mSv, X-ray image converter 0.4mSv), 7.9mSv using a CBCT - flat detector, and 9.9mSv using CT. This corresponds to a factor 26 of DL versus CBCT, or a factor 33 of DL versus CT. In order to minimize X-ray exposure during PRG-procedures for patients and staff, fluoroscopically-guided interventions should employ flat detector systems with short transmittance sequences in low dose mode and with slow image frequency. Series recordings can be dispensed with. The intraprocedural placement of a naso- or orogastric probe significantly extends FT, but has little effect on the overall dose of the

  11. Effects of the breed, sex and age on cellular content and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel

    Directory of Open Access Journals (Sweden)

    Giraldo Carlos E

    2013-02-01

    Full Text Available Abstract Background There is no information on the effects of the breed, gender and age on the cellular content and growth factor (GF release from equine pure-platelet rich plasma (P-PRP and pure-platelet rich gel (P-PRG. The objectives of this study were: 1 to compare the cellular composition of P-PRP with whole blood and platelet poor plasma (PPP; 2 to compare the concentration of transforming GF beta 1 (TGF-β1 and platelet derived GF isoform BB (PDGF-BB between P-PRP treated with non-ionic detergent (P-PRP+NID, P-PRG (activated with calcium gluconate -CG-, PPP+NID, PPP gel (PPG, and plasma and; 3 to evaluate and to correlate the effect of the breed, gender and age on the cellular and GF concentration for each blood component. Forty adult horses, 20 Argentinean Creole Horses (ACH and, 20 Colombian Creole Horses (CCH were included. Data were analyzed by parametric (i.e.: t-test, one way ANOVA and non parametric (Kruskal-Wallis test, Wilcoxon test tests. Correlation analysis was also performed by using the Spearman and Pearson tests. A p ≤ 0.05 was set as significant for all tests. All the blood components were compared for platelet (PLT, leukocyte (WBC, TGF-β1 and PDGF-BB concentrations. The effect of the breed, gender and age on these variables was analyzed. A P ≤ 0.05 was accepted as significant for all the tests. Results PLT counts were 1.8 and 0.6 times higher in P-PRP than in whole blood and PPP, respectively; WBC counts were 0.5 and 0.1 times lower in P-PRP, in comparison with whole blood and PPP, respectively. TGF-β1 and PDGF-BB concentrations were 2.3 and 262 times higher, respectively, in P-PRG than in plasma, and 0.59 and 0.48 times higher, respectively, in P-PRG than in PPG. P-PRG derived from CCH females or young horses presented significantly (P Conclusions Our results indicated that P-PRP obtained by a manual method was affected by intrinsic factors such as the breed, gender and age. Equine practitioners should be

  12. The role of the interventional radiologist in enteral alimentation.

    Science.gov (United States)

    Given, M F; Lyon, S M; Lee, M J

    2004-01-01

    The provision of enteral nutrition through the placement of gastrostomy/gastrojejunostomy tubes is a well-established procedure. Traditionally, these catheters have been placed either surgically or endoscopically; however, over the past two decades interventional radiologists have increasingly performed these procedures successfully. The perceived advantages of this route lie in the reported lower morbidity and mortality rates. In addition, percutaneous radiologically guided (PRG) catheters may be placed in certain subgroups of patients in whom it would be technically difficult or impossible by other routes, e.g., patients with head and neck or oesophageal tumours. The aim of this review is to describe the techniques of radiologically placed gastrostomy/gastrojejunostomy, discuss its indications and contraindications, describe any associated potential complications and compare PRG results with the more established techniques of open surgical and endoscopic placement. We also describe some recent procedural and catheter modifications.

  13. Steroid hormones modulate galectin-1 in the trophoblast HTR-8/SVneocell line

    Directory of Open Access Journals (Sweden)

    Bojić-Trbojević Žanka

    2008-01-01

    Full Text Available The effects of steroids on galectin-1 (gal-1 were studied in HTR-8/SVneo cells by immunocytochemistry, cell-based ELISA, the MTT proliferation test and the Matrigel TM invasion test. Dexamethasone (DEX, progesterone (PRG, and mifepristone (RU486 were used. Gal-1 was modulated in a steroid- and dose-dependent manner by DEX, which mildly but significantly stimulated production at low concentrations (0.1-10 nM, and inhibited it at 100 nM, while the effects of PRG and RU486 were opposite. HTR-8/SVneo cell invasion of Matrigel was significantly decreased in the presence of DEX and lactose. The obtained data support the proposed regulatory role of steroids in trophoblast gal-1 production.

  14. Preliminary remediation goals for use at the U.S. Department of Energy Oak Ridge Operations Office

    International Nuclear Information System (INIS)

    1995-06-01

    This report presents Preliminary Remediation Goals (PRGs) for use in human health risk assessment efforts under the United States Department of Energy, Oak Ridge Operations Office Environmental Restoration (ER) Division. Chemical-specific PRGs are concentration goals for individual chemicals for specific medium and land use combinations. The PRGs are referred to as risk-based because they have been calculated using risk assessment procedures. Risk-based calculations set concentration limits using both carcinogenic or noncarcinogenic toxicity values under specific exposure pathways. The PRG is a concentration that is derived from a specified excess cancer risk level or hazard quotient. This report provides the ER Division with standardized PRGs which are integral to the Remedial Investigation/Feasibility Study process. By managing the assumptions and systems used in PRG derivation, the Environmental Restoration Risk Assessment Program will be able to control the level of quality assurance associated with these risk-based guideline values

  15. Critical excitation spectrum of a quantum chain with a local three-spin coupling.

    Science.gov (United States)

    McCabe, John F; Wydro, Tomasz

    2011-09-01

    Using the phenomenological renormalization group (PRG), we evaluate the low-energy excitation spectrum along the critical line of a quantum spin chain having a local interaction between three Ising spins and longitudinal and transverse magnetic fields, i.e., a Turban model. The low-energy excitation spectrum found with the PRG agrees with the spectrum predicted for the (D(4),A(4)) conformal minimal model under a nontrivial correspondence between translations at the critical line and discrete lattice translations. Under this correspondence, the measurements confirm a prediction that the critical line of this quantum spin chain and the critical point of the two-dimensional three-state Potts model are in the same universality class.

  16. Critical excitation spectrum of a quantum chain with a local three-spin coupling

    International Nuclear Information System (INIS)

    McCabe, John F.; Wydro, Tomasz

    2011-01-01

    Using the phenomenological renormalization group (PRG), we evaluate the low-energy excitation spectrum along the critical line of a quantum spin chain having a local interaction between three Ising spins and longitudinal and transverse magnetic fields, i.e., a Turban model. The low-energy excitation spectrum found with the PRG agrees with the spectrum predicted for the (D 4 ,A 4 ) conformal minimal model under a nontrivial correspondence between translations at the critical line and discrete lattice translations. Under this correspondence, the measurements confirm a prediction that the critical line of this quantum spin chain and the critical point of the two-dimensional three-state Potts model are in the same universality class.

  17. Primary water chemistry monitoring from the point of view of radiation build-up

    International Nuclear Information System (INIS)

    Horvath, G.L.; Civin, V.; Pinter, T.

    1997-01-01

    Basic operational principles of a computer code system calculating the primary circuit corrosion product activities based on actual measured plant chemistry data are presented. The code system consists of two parts: FeSolub.prg: calculates the characteristic iron solubilities based on actual primary water chemistry (H 3 BO 3 KOH, ... etc.) and plant load (MW) data. A developed solubility calculation method has been applied fitted to magnetite solubility data of several authors; RADTRAN.exe: calculates primary circuit water and surface corrosion product activities based on results of FeSolub.prg or planned water chemistry data up to the next shutdown. The computer code system is going to be integrated into a general primary water chemistry monitoring and surveillance system. (author). 15 refs, 4 figs, 3 tabs

  18. The role of the interventional radiologist in enteral alimentation

    Energy Technology Data Exchange (ETDEWEB)

    Given, M.F.; Lyon, S.M.; Lee, M.J. [Department of Academic Radiology, Beaumont Hospital, Dublin 9 (Ireland); Royal College of Surgeons in Ireland, St. Stephen' s Green, Dublin 2 (Ireland)

    2004-01-01

    The provision of enteral nutrition through the placement of gastrostomy/gastrojejunostomy tubes is a well-established procedure. Traditionally, these catheters have been placed either surgically or endoscopically; however, over the past two decades interventional radiologists have increasingly performed these procedures successfully. The perceived advantages of this route lie in the reported lower morbidity and mortality rates. In addition, percutaneous radiologically guided (PRG) catheters may be placed in certain subgroups of patients in whom it would be technically difficult or impossible by other routes, e.g., patients with head and neck or oesophageal tumours. The aim of this review is to describe the techniques of radiologically placed gastrostomy/gastrojejunostomy, discuss its indications and contraindications, describe any associated potential complications and compare PRG results with the more established techniques of open surgical and endoscopic placement. We also describe some recent procedural and catheter modifications. (orig.)

  19. Preliminary remediation goals for use at the U.S. Department of Energy Oak Ridge Operations Office

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    This report presents Preliminary Remediation Goals (PRGs) for use in human health risk assessment efforts under the United States Department of Energy, Oak Ridge Operations Office Environmental Restoration (ER) Division. Chemical-specific PRGs are concentration goals for individual chemicals for specific medium and land use combinations. The PRGs are referred to as risk-based because they have been calculated using risk assessment procedures. Risk-based calculations set concentration limits using both carcinogenic or noncarcinogenic toxicity values under specific exposure pathways. The PRG is a concentration that is derived from a specified excess cancer risk level or hazard quotient. This report provides the ER Division with standardized PRGs which are integral to the Remedial Investigation/Feasibility Study process. By managing the assumptions and systems used in PRG derivation, the Environmental Restoration Risk Assessment Program will be able to control the level of quality assurance associated with these risk-based guideline values.

  20. Renormalization group treatment of bond percolation in anisotropic and 'inhomogeneous' planar lattices

    International Nuclear Information System (INIS)

    Magalhaes, A.C.N. de; Tsallis, C.; Schwaccheim, G.

    1980-04-01

    The uncorrelated bond percolation problem is studied in three planar systems where there are two distinct occupancy probabilities. Two different real space renormalization group approaches (referred as the 'canonical' (CRG) and the 'parametric' (PRG) ones) are applied to the anisotropic first-neighbour square lattice, and both of them exhibit the expected tendency towards the exactly known phase boundary (p+q=1). Then, within the context of PRG calculations for increasingly large cells, an extrapolation method is introduced, which leads to analytic proposals for the other two lattices, namely p+q = 1/2 for the first-and second-neighbour square lattice (p and q are, respectively, the first and second neighbour occupancy probabilities), and 3 (p-1/2) = 4 [(1-q) 2 + (1-q) 3 ] (p and q are, respectively, the occupancy probabilities of the topologically different bonds which are in a 1:2 ratio) for the 4- 8 lattice. (Author) [pt

  1. Primary water chemistry monitoring from the point of view of radiation build-up

    Energy Technology Data Exchange (ETDEWEB)

    Horvath, G L [Institute for Electrical Power Research, Budapest (Hungary); Civin, V [Hungarian Electricity Generating Board, Budapest (Hungary); Pinter, T [Nuclear Power Plant PAKS, Budapest (Hungary)

    1997-02-01

    Basic operational principles of a computer code system calculating the primary circuit corrosion product activities based on actual measured plant chemistry data are presented. The code system consists of two parts: FeSolub.prg: calculates the characteristic iron solubilities based on actual primary water chemistry (H{sub 3}BO{sub 3}KOH, ... etc.) and plant load (MW) data. A developed solubility calculation method has been applied fitted to magnetite solubility data of several authors; RADTRAN.exe: calculates primary circuit water and surface corrosion product activities based on results of FeSolub.prg or planned water chemistry data up to the next shutdown. The computer code system is going to be integrated into a general primary water chemistry monitoring and surveillance system. (author). 15 refs, 4 figs, 3 tabs.

  2. Automating the design of resection guides specific to patient anatomy in knee replacement surgery by enhanced 3D curvature and surface modeling of distal femur shape models.

    Science.gov (United States)

    Cerveri, Pietro; Manzotti, Alfonso; Confalonieri, Norberto; Baroni, Guido

    2014-12-01

    Personalized resection guides (PRG) have been recently proposed in the domain of knee replacement, demonstrating clinical outcome similar or even superior to both manual and navigated interventions. Among the mandatory pre-surgical steps for PRG prototyping, the measurement of clinical landmarks (CL) on the bony surfaces is recognized as a key issue due to lack of standardized methodologies, operator-dependent variability and time expenditure. In this paper, we focus on the reliability and repeatability of an anterior-posterior axis, also known as Whiteside line (WL), of the distal femur proposing automatic surface processing and modeling methods aimed at overcoming some of the major concerns related to the manual identification of such CL on 2D images and 3D models. We show that the measurement of WL, exploiting the principle of mean-shifting surface curvature, is highly repeatable and coherent with clinical knowledge. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Durable Flap-Valve Mitigation of Duodenogastric Reflux,  Remnant Gastritis and Dumping Syndrome Following Billroth I Reconstruction.

    Science.gov (United States)

    Hoya, Yoshiyuki; Taki, Tetsuya; Watanabe, Atsushi; Nakayoshi, Tomoko; Okamoto, Tomoyoshi; Mitsumori, Norio; Yanaga, Katsuhiko

    2016-04-01

    We have reported the short-term results of pylorus reconstruction gastrectomy (PRG) that prevents duodenogastric reflux (DGR) and remnant gastritis after distal gastrectomy. We herein report the long-term results of the PRG. PRG was performed in 37 patients (age 31 to 86 [mean 67.8 ± 12.3] years, male:female = 22:15) with gastric cancer from June 2006 through December 2013. We examined the long-term outcome in 28 patients (age 41 to 86 [mean 67.0 ± 10.7] years, male:female = 18:10) that passed over 3 years after surgery (LTR 44.1 ± 11.7 months), and compared with their short-term result after the operation (STR 13.1 ± 6.9 months). The adverse events of gastric surgery evaluated in this study consisted of the degree of remnant gastritis, the presence of dumping syndrome, and degree of weight loss (%). There was no difference in the degree of DGR and remnant gastritis by gastroscopic finding between LTR and STR after PRG (P = 0.21). Statistically, there was no difference in the bile acid concentration of remnant gastric juice between LTR and STR (108.4 ± 254.1 vs. 94.0 ± 208.6 μmol/L, P = 0.33), and weight loss of LTR was the same as that of STR (5.67 ± 7.08 vs. 4.59 ± 5.63%, P = 0.34). There were few morphological changes in the reconstructed pylorus by the long-term course, but 2 patients showed mild atrophy. The form of reconstructed pylorus and the effect that reduces side effects of Billroth I seem to last for a long time.

  4. Tribosupplementation with Lubricin in Prevention of Post-Traumatic Arthritis

    Science.gov (United States)

    2015-12-01

    cells. This level of expression is commercially scalable and will thus enable production of a GMP protein for clinical use . A purification bioprocess...utilizing anion exchange, hydroxyapatite and a hydrophobic exchange media resins achieves a high level of purity. Explants of bovine articular...performed another study in porcine following meniscal injury, which was funded by a Phase 2 STTR (1R42AR057276 PI: Jay) using the same rhPRG4 also

  5. Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET

    International Nuclear Information System (INIS)

    Deroose, Christophe M.; Chitneni, Satish K.; Gijsbers, Rik; Vermaelen, Peter; Ibrahimi, Abdelilah; Balzarini, Jan; Baekelandt, Veerle; Verbruggen, Alfons; Nuyts, Johan; Debyser, Zeger; Bormans, Guy M.

    2012-01-01

    Introduction: Imaging of gene expression with positron emission tomography (PET) has emerged as a powerful tool for biomedical research during the last decade. The prototypical herpes simplex virus type 1 thymidine kinase (HSV1-TK) PET reporter gene (PRG) is widely used and many other PRGs have also been validated. We investigated varicella zoster virus thymidine kinase (VZV-tk) as new PRG with radiolabeled bicyclic nucleoside analogues (BCNAs) as PET tracers. Methods: The uptake and washout of four different radiolabeled BCNAs was evaluated in cells expressing VZV-tk after lentiviral vector (LV) transduction and in control cells. Metabolism of the tracers was assayed by high pressure liquid chromatography (HPLC). Mice bearing VZV-TK expressing xenografts were imaged with PET. Results: High uptake in VZV-tk expressing cells was seen for 3 of the 4 tracers tested. The uptake of the tracers could be blocked by the presence of excess thymidine in the incubation solution. Cellular retention was variable, with one tracer showing an acceptable half-life of ∼ 1 hour. The amount of intracellular tracer correlated with the titer of LV used to transduce the cells. VZV-TK dependent conversion into metabolites was shown by HPLC. No specific accumulation was observed in cells expressing a fusion protein containing an HSV1-TK moiety. VZV-tk expression in xenografts resulted in a 60% increase in uptake in vivo as measured with PET. Conclusions: We have validated the combination of VZV-tk and radiolabeled BCNAs as new PRG/PRP system. Further optimization of the PRPs and the PRG are warranted to increase the signal.

  6. A Latent Class Analysis of Pathological-Gambling Criteria Among High School Students: Associations With Gambling, Risk and Health/Functioning Characteristics

    Science.gov (United States)

    Kong, Grace; Tsai, Jack; Krishnan-Sarin, Suchitra; Cavallo, Dana A.; Hoff, Rani A.; Steinberg, Marvin A.; Rugle, Loreen; Potenza, Marc N.

    2015-01-01

    Objectives To identify subtypes of adolescent gamblers based on the 10 Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria for pathological gambling and the 9 Diagnostic and Statistical Manual of Mental Disorders, fifth edition criteria for gambling disorder and to examine associations between identified subtypes with gambling, other risk behaviors, and health/functioning characteristics. Methods Using cross-sectional survey data from 10 high schools in Connecticut (N = 3901), we conducted latent class analysis to classify adolescents who reported past-year gambling into gambling groups on the basis of items from the Massachusetts Gambling Screen. Adolescents also completed questions assessing demographic information, substance use (cigarette, marijuana, alcohol, and other drugs), gambling behaviors (relating to gambling formats, locations, motivations, and urges), and health/functioning characteristics (eg, extracurricular activities, mood, aggression, and body mass index). Results The optimal solution consisted of 4 classes that we termed low-risk gambling (86.4%), at-risk chasing gambling (7.6%), at-risk negative consequences gambling (3.7%), and problem gambling (PrG) (2.3%). At-risk and PrG classes were associated with greater negative functioning and more gambling behaviors. Different patterns of associations between at-risk and PrG classes were also identified. Conclusions Adolescent gambling classifies into 4 classes, which are differentially associated with demographic, gambling patterns, risk behaviors, and health/functioning characteristics. Early identification and interventions for adolescent gamblers should be sensitive to the heterogeneity of gambling subtypes. PMID:25275877

  7. Human Health Risk Assessment of 16 Priority Polycyclic Aromatic Hydrocarbons in Soils of Chattanooga, Tennessee, USA.

    Science.gov (United States)

    Hussar, Erika; Richards, Sean; Lin, Zhi-Qing; Dixon, Robert P; Johnson, Kevin A

    2012-11-01

    South Chattanooga has been home to foundries, coke furnaces, chemical, wood preserving, tanning and textile plants for over 100 years. Most of the industries were in place before any significant development of residential property in the area. During the 1950s and 1960s, however, the government purchased inexpensive property and constructed public housing projects in South Chattanooga. Many neighborhoods that surround the Chattanooga Creek were previous dumping grounds for industry. Polycyclic aromatic hydrocarbons (PAHs) comprised the largest component of the dumping and airborne industrial emissions. To address the human exposure to these PAHs, a broad study of South Chattanooga soil contaminant concentrations was conducted on 20 sites across the city. Sixteen priority pollutant PAHs were quantified at two depths (0-10cm and 10-20cm) and compared against reference site soils, as well as to soils from industrially-impacted areas in Germany, China, and the US. From these data, the probability that people would encounter levels exceeding EPA Residential Preliminary Remediation Goals (PRG) was calculated. Results indicate that South Chattanooga soils have relatively high concentrations of total PAHs, specifically Benzo[a]pyrene (B[a]P). These high concentrations of B[a]P were somewhat ubiquitous in South Chattanooga. Indeed, there is a high probability (88%) of encountering soil in South Chattanooga that exceeds the EPA PRG for B[a]P. However, there is a low probability (15%) of encountering a site with ∑PAHs exceeding EPA PRG guidelines.

  8. Early detection of pathological gambling: betting on GPs' beliefs and attitudes.

    Science.gov (United States)

    Achab, Sophia; Chatton, Anne; Khan, Riaz; Thorens, Gabriel; Penzenstadler, Louise; Zullino, Daniele; Khazaal, Yasser

    2014-01-01

    Pathological gambling (PG) is an addictive disorder with harm related to the high psychiatric comorbidity and increased suicidal risk. Prevalence rates in general population range from 0.2% to 2.1%. Problem gamblers are hard to attract to treatment programs for several proper reasons and for obstacles (e.g., accessibility). To address these obstacles, primary care (where the problem gambling (PrG) prevalence seems to be 6.2%) has a crucial role to play (i.e., identifying and referring patients to specialized treatment programs and treating at first line when needed and possible) in the era of online gambling offer expansion. The present work aimed to collect data on resources in the field from GPs themselves, using a 24-item online questionnaire. Swiss French-speaking participants were asked about their screening practice and knowledge. The results state that the vast majority of them are aware of the existence and the potential impact of PrG on their patients. However, PrG screening is not systematic and their knowledge of adequate treatments or referral methods is scarce. GPs being central to health screening in general, targeted advice and training on short screening tools and better knowledge of referral pathways should be promoted and continued to empower the GP's management skills in a public health approach.

  9. Early Detection of Pathological Gambling: Betting on GPs’ Beliefs and Attitudes

    Directory of Open Access Journals (Sweden)

    Sophia Achab

    2014-01-01

    Full Text Available Pathological gambling (PG is an addictive disorder with harm related to the high psychiatric comorbidity and increased suicidal risk. Prevalence rates in general population range from 0.2% to 2.1%. Problem gamblers are hard to attract to treatment programs for several proper reasons and for obstacles (e.g., accessibility. To address these obstacles, primary care (where the problem gambling (PrG prevalence seems to be 6.2% has a crucial role to play (i.e., identifying and referring patients to specialized treatment programs and treating at first line when needed and possible in the era of online gambling offer expansion. The present work aimed to collect data on resources in the field from GPs themselves, using a 24-item online questionnaire. Swiss French-speaking participants were asked about their screening practice and knowledge. The results state that the vast majority of them are aware of the existence and the potential impact of PrG on their patients. However, PrG screening is not systematic and their knowledge of adequate treatments or referral methods is scarce. GPs being central to health screening in general, targeted advice and training on short screening tools and better knowledge of referral pathways should be promoted and continued to empower the GP’s management skills in a public health approach.

  10. Shear bond strengths of tooth coating materials including the experimental materials contained various amounts of multi-ion releasing fillers and their effects for preventing dentin demineralization.

    Science.gov (United States)

    Arita, Shoko; Suzuki, Masaya; Kazama-Koide, Miku; Shinkai, Koichi

    2017-10-01

    We examined shear bond strengths (SBSs) of various tooth-coating-materials including the experimental materials to dentin and demineralization resistance of a fractured adhesive surface after the SBS testing. Three resin-type tooth-coating-materials (BC, PRG Barrier Coat; HC, Hybrid Coat II; and SF, Shield force plus) and two glass-ionomer-type tooth-coating-materials (CV, Clinpro XT Varnish; and FJ, Fuji VII) were selected. The experimental PRG Barrier Coat containing 0, 17, and 33 wt% S-PRG filler (BC0, BC17, and BC33, respectively) were developed. Each tooth-coating-material was applied to flattened dentin surfaces of extracted human teeth for SBS testing. After storing in water for 32 days with 4000 thermal cycling, the specimens were subjected to the SBS test. Specimens after SBS testing were subjected to a pH cycling test, and then, demineralization depths were measured using a polarized-light microscope. ANOVA and Tukey's HSD test were used for statistical analysis. The SBS value of FJ and CV was significantly lower than those of other materials except for BC (p coating-materials demonstrated significantly higher SBS for dentin than the glass-ionomer-type tooth-coating-materials; however, they were inferior to the glass ionomer-type tooth-coating-materials in regards to the acid resistance of the fractured adhesion surface.

  11. Basal and β-Adrenergic Cardiomyocytes Contractility Dysfunction Induced by Dietary Protein Restriction is Associated with Downregulation of SERCA2a Expression and Disturbance of Endoplasmic Reticulum Ca2+ Regulation in Rats

    Directory of Open Access Journals (Sweden)

    Arlete R. Penitente

    2014-07-01

    Full Text Available Background: The mechanisms responsible for the cardiac dysfunction associated with dietary protein restriction (PR are poorly understood. Thus, this study was designed to evaluate the effects of PR on calcium kinetics, basal and β-adrenergic contractility in murine ventricular cardiomyocytes. Methods: After breastfeeding male Fisher rats were distributed into a control group (CG, n = 20 and a protein-restricted group (PRG, n = 20, receiving isocaloric diets for 35 days containing 15% and 6% protein, respectively. Biometric and hemodynamic variables were measured. After euthanasia left ventricles (LV were collected for histopathological evaluation, SERCA2a expression, cardiomyocytes contractility and Ca2+sparks analysis. Results: PRG animals showed reduced general growth, increased heart rate and arterial pressure. These animals presented extracellular matrix expansion and disorganization, cardiomyocytes hypotrophy, reduced amplitudes of shortening and maximum velocity of contraction and relaxation at baseline and after β-adrenergic stimulation. Reduced SERCA2a expression as well as higher frequency and lower amplitude of Ca2+sparks were observed in PRG cardiomyocytes. Conclusion: The observations reveal that protein restriction induces marked myocardial morphofunctional damage. The pathological changes of cardiomyocyte mechanics suggest the potential involvement of the β-adrenergic system, which is possibly associated with changes in SERCA2a expression and disturbances in Ca2+ intracellular kinetics.

  12. Coordinating the Structural Rearrangements Associated with Unidirectional Proton Transfer in the Bacteriorhodopsin Photocycle Induced by Deprotonation of the Proton-Release Group: A Time-Resolved Difference FTIR Spectroscopic Study†

    Science.gov (United States)

    Morgan, Joel E.; Vakkasoglu, Ahmet S.; Lanyi, Janos K.; Gennis, Robert B.; Maeda, Akio

    2014-01-01

    In the photocycle of bacteriorhodopsin at pH 7, proton release from the proton releasing group (PRG) to the extracellular medium occurs during formation of the M intermediate. This proton release is inhibited at acidic pH, below the pKa of the PRG, ∼6 in M, and instead occurs later in the cycle as the initial state is restored from the O intermediate. Here, structural changes related to deprotonation of the PRG have been investigated by time-resolved FTIR spectroscopy at 25°C. The vibrational features at 2100-1790 cm-1, 1730-1685 cm-1, 1661 cm-1, and 1130-1045 cm-1 have greater negative intensity in the pure M-minus-BR spectrum and even in the M-minus-BR spectrum, that is present earlier together with the L-minus-BR spectrum, at pH 7, than in the corresponding M-minus-BR spectra at pH 5 or pH 4. The D212N mutation abolishes the decreases in the intensities of the broad feature between 1730 and 1685 cm-1 and the band at 1661 cm-1. The 1730-1685 cm-1 feature may arise from transition dipole coupling of the backbone carbonyl groups of Glu204, Phe208, Asp212 and Lys216 interacting with Tyr57 and C15-H of the chromophore. The 1661 cm-1 band, which is insensitive to D2O substitution, may arise by interaction of the backbone carbonyl of Asp212 with C15-H. The 2100-1790 cm-1 feature with a trough at 1885 cm-1 could be due to a water cluster. Depletion of these bands upon deprotonation of the PRG is attributable to disruption of a coordinated structure, held in place by interactions of Asp212. Deprotonation of the PRG is accompanied also by disruption of the interaction of the water molecule near Arg82. The liberated Asp212 may stabilize the protonated state of Asp85, and thus confer uni-directionality to the transport. PMID:20232848

  13. Eesti teatri aastaauhinnad 2004

    Index Scriptorium Estoniae

    2005-01-01

    Lavastajaauhind Tiit Ojasoo, naisnäitleja auhind Epp Eespäev, meesnäitleja Hendrik Toompere jun, naiskõrvalosatäitja Kadri Lepp, meeskõrvalosatäitja Herardo Kontreras, kunstnikuauhind Jaak Vaus, žürii eriauhind lavastaja Anne Türnpule ja kunstnik Liina Tepandile "Valgelaev ja taevakäijad" eest, kriitikuauhind Kristiina Garancis, Kristallkingakese auhind Mirtel Pohla ja Kaspar Jancis, muusikalavastuse auhind "Eesti ballaadid" kooslusele ja Heli Veskusele, tantsulavastuse auhind Maria Seletskajale ja ZUGA Ühendatud Tantsijatele, Priit Põldroosi preemia Aime Unt, Ants Lauteri preemia Indrek Saar, Liina Vahtrik, Salme Reegi preemia Peeter Tammearu, Aleksander Kurtna preemia Martin Algus, Natalie Mei preemia Eldor Renter, balleti- ja tantsulavastuse eriauhind Kaie Kõrb, Georg Otsa preemia Mati Kõrts, parima teatritöötaja auhind : Riina Roose, Jane Kaas, Ott Mölter, Eda Kaljo, Aino Kartul, Kaja Kupp, Ain Jürisson, Jelena Oleinikova, Kalle Kuningas ja Moonika Lausvee

  14. Modelling environmentally friendly fairways using Lagrangian trajectories: a case study for the Gulf of Finland, the Baltic Sea

    Science.gov (United States)

    Soomere, Tarmo; Berezovski, Mihhail; Quak, Ewald; Viikmäe, Bert

    2011-10-01

    We address possibilities of minimising environmental risks using statistical features of current-driven propagation of adverse impacts to the coast. The recently introduced method for finding the optimum locations of potentially dangerous activities (Soomere et al. in Proc Estonian Acad Sci 59:156-165, 2010) is expanded towards accounting for the spatial distributions of probabilities and times for reaching the coast for passively advecting particles released in different sea areas. These distributions are calculated using large sets of Lagrangian trajectories found from Eulerian velocity fields provided by the Rossby Centre Ocean Model with a horizontal resolution of 2 nautical miles for 1987-1991. The test area is the Gulf of Finland in the northeastern Baltic Sea. The potential gain using the optimum fairways from the Baltic Proper to the eastern part of the gulf is an up to 44% decrease in the probability of coastal pollution and a similar increase in the average time for reaching the coast. The optimum fairways are mostly located to the north of the gulf axis (by 2-8 km on average) and meander substantially in some sections. The robustness of this approach is quantified as the typical root mean square deviation (6-16 km) between the optimum fairways specified from different criteria. Drastic variations in the width of the `corridors' for almost optimal fairways (2-30 km for the average width of 15 km) signifies that the sensitivity of the results with respect to small changes in the environmental criteria largely varies in different parts of the gulf.

  15. Effect of antioxidants on the oxidative stability of methyl soyate (biodiesel)

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Robert O. [Food and Industrial Oils Research, USDA, Agricultural Research Service, National Center for Agricultural Utilization Research, 1815 N. University St., Peoria, IL 61604-3999 (United States)

    2005-06-25

    Biodiesel, an alternative diesel fuel derived from transesterification of vegetable oils or animal fats, is composed of saturated and unsaturated long-chain fatty acid alkyl esters. When exposed to air during storage, autoxidation of biodiesel can cause degradation of fuel quality by adversely affecting properties such as kinematic viscosity, acid value and peroxide value. One approach for increasing resistance of fatty derivatives against autoxidation is to treat them with oxidation inhibitors (antioxidants). This study examines the effectiveness of five such antioxidants, tert-butylhydroquinone (TBHQ), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate (PrG) and {alpha}-Tocopherol in mixtures with soybean oil fatty acid methyl esters (SME). Antioxidant activity in terms of increasing oxidation onset temperature (OT) was determined by non-isothermal pressurized-differential scanning calorimetry (P-DSC). Analyses were conducted in static (zero gas flow) and dynamic (positive gas flow) mode under 2000 kPa (290 psig) pressure and 5 {sup o}C/min heating scan rate. Results showed that PrG, BHT and BHA were most effective and {alpha}-Tocopherol least effective in increasing OT. Increasing antioxidant loading (concentration) showed sharp increases in activity for loadings up to 1000 ppm followed by smaller increases in activity at higher loadings. Phase equilibrium studies were also conducted to test physical compatibility of antioxidants in SME-No. 2 diesel fuel (D2) blends. Overall, this study recommends BHA or TBHQ (loadings up to 3000 ppm) for safeguarding biodiesel from effects of autoxidation during storage. BHT is also suitable at relatively low loadings (210 ppm after blending). PrG showed some compatibility problems and may not be readily soluble in blends with larger SME ratios. Although {alpha}-Tocopherol showed very good compatibility in blends, it was significantly less effective than the synthetic antioxidants screened in this

  16. Comparative evaluation of fluoride release and recharge of pre-reacted glass ionomer composite and nano-ionomeric glass ionomer with daily fluoride exposure: An in vitro study

    Directory of Open Access Journals (Sweden)

    Jayanthi Mungara

    2013-01-01

    Full Text Available Aim: This in vitro study was designed to investigate the effects of daily fluoride exposures on fluoride release and recharge by prereacted glass ionomer (PRG composite and nano-ionomeric glass ionomer. Materials and Methods: Seventy-two specimens (36 of each material were prepared and by placing the restorative materials into Teflon mold. Each specimen was subjected to one of three daily treatments (n = 12: (1 No fluoride treatment (control; (2 application of a fluoride dentifrice (1,000 ppm once daily; and (3 the same regimen as (2, plus immersion in a 0.05% sodium fluoride (NaF mouth rinse (225 ppm immediately following the dentifrice application. Specimens were suspended in a storage vial containing 10 ml demineralizing solution for 6 h and transferred to a new test tube containing 10 ml remineralizing solution for 18 h. Fluoride treatments of the specimens were completed every day prior to their immersion in the demineralizing solution. Media solutions were buffered with equal volumes of total ionic strength adjustment buffer (TISAB II; fluoride levels were measured using a digital ion analyzer and fluoride electrode throughout the 21 day duration of the experiment. Results: Nano-ionomeric glass ionomer showed a better amount of fluoride release than PRG composite irrespective of the fluoride treatment supplementation (P < 0.01. Additional fluoride supplementation improved fluoride release and recharge ability for both the materials when compared to their respective control groups. The fluoride recharge for both materials did not show any sustained pattern of release. Conclusion: Nano-ionomeric glass ionomer demonstrated a greater ability to release and recharge compared with that of PRG composite.

  17. Antiseptic solutions modulate the paracrine-like activity of bone chips: differential impact of chlorhexidine and sodium hypochlorite.

    Science.gov (United States)

    Sawada, Kosaku; Caballé-Serrano, Jordi; Bosshardt, Dieter D; Schaller, Benoit; Miron, Richard J; Buser, Daniel; Gruber, Reinhard

    2015-09-01

    Chemical decontamination increases the availability of bone grafts; however, it remains unclear whether antiseptic processing changes the biological activity of bone. Bone chips were incubated with four different antiseptic solutions including (1) povidone-iodine (0.5%), (2) chlorhexidine diguluconate (0.2%), (3) hydrogen peroxide (1%) and (4) sodium hypochlorite (0.25%). After 10 min. of incubation, changes in the capacity of the bone-conditioned medium (BCM) to modulate gene expression of gingival fibroblasts was investigated. Conditioned medium obtained from freshly prepared bone chips increased the expression of TGF-β target genes interleukin 11 (IL11), proteoglycan4 (PRG4), NADPH oxidase 4 (NOX4), and decreased the expression of adrenomedullin (ADM), and pentraxin 3 (PTX3) in gingival fibroblasts. Incubation of bone chips with 0.2% chlorhexidine, followed by vigorously washing resulted in a BCM with even higher expression of IL11, PRG4 and NOX4. These findings were also detected with a decrease in cell viability and an activation of apoptosis signalling. Chlorhexidine alone, at low concentrations, increased IL11, PRG4 and NOX4 expression, independent of the TGF-β receptor I kinase activity. In contrast, 0.25% sodium hypochlorite almost entirely abolished the activity of BCM, whereas the other two antiseptic solutions, 1% hydrogen peroxide and 0.5% povidone-iodine, had relatively no impact respectively. These in vitro findings demonstrate that incubation of bone chips with chlorhexidine differentially affects the activity of the respective BCM compared to the other antiseptic solutions. The data further suggest that the main effects are caused by chlorhexidine remaining in the BCM after repeated washing of the bone chips. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. Ruminal protozoal contribution to the duodenal flow of fatty acids following feeding of steers on forages differing in chloroplast content.

    Science.gov (United States)

    Huws, S A; Lee, M R F; Kingston-Smith, A H; Kim, E J; Scott, M B; Tweed, J K S; Scollan, N D

    2012-12-28

    Ruminant products are criticised for their SFA content relative to PUFA, although n-6:n-3 PUFA is desirable for human health ( content of rumen protozoa offers a potentially novel approach to enhance PUFA flow to the duodenum and subsequent incorporation into meat and milk. We evaluated protozoal contribution to duodenal n-3 PUFA flow due to intracellular chloroplast content. A total of six Holstein × Friesian steers were fed, in a two-period changeover design, either straw:concentrate (S:C, 60:40; DM basis; S:C, low chloroplast) or fresh perennial ryegrass (PRG; high chloroplast). Following 12 d adaptation to diet, ruminal protozoal and whole duodenal samples were obtained. N and fatty acid content of whole duodenum and rumen protozoal samples were assessed and protozoal 18S rDNA quantitative PCR performed, enabling calculation of protozoal N flow. The ratio of individual fatty acids:N in rumen protozoal samples was calculated to obtain protozoal fatty acid flows. Based on total fatty acid flow, contribution (%) of protozoa to individual fatty acid flows was calculated. Protozoal fatty acid data and microscopical observations revealed that protozoa were enriched with 18 : 3n-3 following PRG feeding, compared with the S:C diet, due to increased intracellular chloroplast content. However, duodenal protozoal 18S rDNA concentration post PRG feeding was low, indicating rumen retention of the protozoa. Nutrition influences the 18 : 3n-3 content of protozoa; the challenge is to increase protozoal flow to the small intestine, while maintaining sustainable rumen densities.

  19. The impact of patient participation direct enhanced service on patient reference groups in primary care: a qualitative study.

    Science.gov (United States)

    Pollard, Lorraine; Agarwal, Shona; Harrad, Fawn; Lester, Louise; Cross, Ainsley; Wray, Paula; Smith, Gordon; Locke, Anthony; Sinfield, Paul

    2014-01-01

    NHS policy documents continue to make a wide-ranging commitment to patient involvement. The Patient Participation Direct Enhanced Service (PP-DES), launched in 2011, aimed to ensure patients are involved in decisions about the range and quality of services provided and commissioned by their practice through patient reference groups (PRGs). The aim of this exploratory study is to review the impact of the PP-DES (2011-13) on a sample of PRGs and assess how far it has facilitated their involvement in decisions about the services of their general practices. A qualitative methods design, using semi- structured interviews and focus groups, was employed to explore the experiences and views of GP practice staff (n = 24), PRG members (n = 80) at 12 GP practices, and other stakeholders (n = 4). Wide variation in the role and remit of the participating PRGs was found, which broadly ranged from activities to improve practice resources to supporting health promotion activities. The majority of PRG members were unfamiliar with the PP-DES scheme and its aims and purpose. Stakeholders and practice staff felt strongly that the main success of the PP-DES was that it had led to an increase in the number of PRGs being established in the locality. The PP-DES scheme has been a catalyst to establish PRGs. However, the picture was mixed in terms of the PRGs involvement in decisions about the services provided at their general practice as there was wide variation in the PRGs role and remit. The financial incentive alone, provided via the DES scheme, did not secure greater depth of PRG activity and power, however, as social factors were identified as playing an important role in PRGs' level of participation in decision making. Many PRGs have to become more firmly established before they are involved as partners in commissioning decisions at their practice.

  20. Nuclear safety improvement activities related to WWER-440 units in Bulgaria

    International Nuclear Information System (INIS)

    Gantchev, T.

    1998-01-01

    The systematic evaluation of the deficiencies of the original design of the WWER reactors brought to the development of a Short Term Programme for Safety Upgrading and Modernisation of Kozloduy WWER-440 units. The implementation of this Programme was completed in 1997. The strive for continuos improvement of Kozloduy Nuclear Power Plant (NPP) safety level, the new requirements of the Bulgarian Nuclear Safety Authority and the public concern initiated the development of new Complex Programme for Safety Improvement (PRG'97), now in a process of implementation. (author)

  1. Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy

    Directory of Open Access Journals (Sweden)

    Kim J

    2016-07-01

    Full Text Available Jiyeon Kim,1 Seong Hoon Kim,2 Sung Chul Lim,2 Woojun Kim,2 Young-Min Shon3 1Department of Neurology, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan, 2Department of Neurology, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seocho-gu, 3Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Purpose: To evaluate the evolution of nonlesional temporal lobe epilepsy (TLE-NL in patients treated exclusively with antiepileptic drugs and to elucidate clinical phenotypes related to the prognosis of these patients.Methods: Clinical, radiological, and electroencephalographic (EEG findings in 84 patients with TLE-NL were reviewed. A good response group (GRG and a poor response group (PRG were defined if the duration of their seizure-free period was >1 year, or <1 year, respectively.Results: There were 46 (54.8% patients in the GRG and 38 (45.2% patients in the PRG. The number of antiepileptic drugs administered was significantly lower in the GRG than that in the PRG (1.3±0.8 vs 2.8±1.0, respectively; P<0.05. The GRG had a significantly older age of onset than the PRG and a lower occurrence of initial precipitating events, such as febrile seizures, central nervous system infection, and head trauma (P<0.05. The prevalence of EEG abnormality, presence of aura, generalized seizures, and automatism was less frequently observed in the GRG (P<0.05. Multivariate analysis showed that the presence of automatism and initial precipitating events were significantly associated with a poor prognosis (P<0.05.Conclusion: In contrast to the commonly assumed intractability of TLE, we found that more than 54% of patients with TLE-NL achieved a long seizure-free period. Older age at onset of TLE-NL was associated with a better prognosis. However, the presence of automatism and initial precipitating events were related to a poor prognosis. Future prospective

  2. Effects of sodium citrate and acid citrate dextrose solutions on cell counts and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel.

    Science.gov (United States)

    Giraldo, Carlos E; Álvarez, María E; Carmona, Jorge U

    2015-03-14

    There is a lack information on the effects of the most commonly used anticoagulants for equine platelet rich plasmas (PRPs) elaboration on cell counts and growth factor release from platelet rich gels (PRGs). The aims of this study were 1) to compare the effects of the anticoagulants sodium citrate (SC), acid citrate dextrose solution A (ACD-A) and ACD-B on platelet (PLT), leukocyte (WBC) and on some parameters associated to platelet activation including mean platelet volume (MPV) and platelet distribution width (PDW) between whole blood, pure PRP (P-PRP) and platelet-poor plasma (PPP); 2) to compare transforming growth factor beta 1 (TGF-β(1)) and platelet-derived growth factor isoform BB (PDGF-BB) concentrations in supernatants from pure PRG (P-PRG), platelet-poor gel (PPG), P-PRP lysate (positive control) and plasma (negative control); 3) to establish the possible correlations between all the studied cellular and molecular parameters. In all cases the three anticoagulants produced P-PRPs with significantly higher PLT counts compared with whole blood and PPP. The concentrations of WBCs were similar between P-PRP and whole blood, but significantly lower in PPP. The type of anticoagulant did not significantly affect the cell counts for each blood component. The anticoagulants also did not affect the MPV and PDW parameters. Independently of the anticoagulant used, all blood components presented significantly different concentrations of PDGF-BB and TGF-β(1). The highest growth factor (GF) concentrations were observed from P-PRP lysates, followed by PRG supernatants, PPP lysates, PPG supernatants and plasma. Significant correlations were observed between PLT and WBC counts (ρ = 0.80), PLT count and TGF-β(1) concentration (ρ = 0.85), PLT count and PDGF-BB concentration (ρ = 0.80) and PDGF-BB and TGF-β(1) concentrations (ρ = 0.75). The type of anticoagulant was not correlated with any of the variables evaluated. The anticoagulants did not

  3. INM Integrated Noise Model Version 2. Programmer’s Guide

    Science.gov (United States)

    1979-09-01

    CURVA-*1RE C ’P - RADIANS "F ARC IELT - ANILE RETWEEr T^OSISITVE X DIPECTION ArD A LINE JOINING THE CEV𔄁E "F THE CURVE WITH THE BrGINNING OF THE...E TkD!E rOP GENF1 INTEPPOIATIO’l C IELT - RATIC CF PrgEfl SETTIVIP TC THAT REQUIRED PCR FINAL C" Pt’r TYP A"TIT"’nE C E"D - END fF "ST"TCrIC’: %O!IE

  4. Changes in coping behavior and the relationship to personality, health threat communication and illness perceptions from the diagnosis of diabetes: a 2-year prospective longitudinal study

    Directory of Open Access Journals (Sweden)

    Valerie L. Lawson

    2013-08-01

    Full Text Available Coping behavior is of critical importance in diabetes because of its impact upon self-care and hence eventual medical outcome. We examined how coping behavior and its relationship to personality, diabetes health threat communication (DHTC and illness representations changes after diagnosis of diabetes. Newly diagnosed diabetic patients were assessed after diagnosis and at 6, 12 and 24 months using the DHTC, Illness Perceptions and Coping inventory questionnaires. Personality traits were assessed at baseline. Active coping, planning, positive reinterpretation and growth (PRG, seeking emotional and instrumental (social support decreased over the 2 years from diagnosis while passive acceptance increased. Openness/intellect and conscientiousness traits were associated with active coping and seeking instrumental support. Openness/intellect also associated with planning and PRG. These relationships did not vary over time. Perceived threat and serious consequences were associated with active coping but the effect diminished over time. Illness coherence (understanding of diabetes, personal and treatment control were associated with active coping, planning and seeking instrumental support and did not change over time. The coping strategies most commonly employed by diabetic patients are adaptive. Coping behavior changes over the 2 years from diagnosis. Promoting better understanding of diabetes, perceptions of personal control and treatment effectiveness are more likely than perception of health threat to sustain adaptive problem focused coping behavior.

  5. Packaging review guide for reviewing safety analysis reports for packagings: Revision 1

    International Nuclear Information System (INIS)

    Fisher, L.E.; Chou, C.K.; Lloyd, W.R.; Mount, M.E.; Nelson, T.A.; Schwartz, M.W.; Witte, M.C.

    1988-10-01

    The Department of Energy (DOE) has established procedures for obtaining certification of packagings used by DOE and its contractors for the transport of radioactive materials. The principal purpose of this document is to assure the quality and uniformity of PCS reviews and to present a well-defined base from which to evaluate proposed changes in the scope and requirements of reviews. The Packaging Review Guide (PRG) also sets forth solutions and approaches determined to be acceptable in the past in dealing with a specific safety issue or safety-related design area. These solutions and approaches are presented in this form so that reviewers can take consistent and well-understood positions as the same safety issues arise in future cases. An applicant submitting a SARP does not have to follow the solutions or approaches presented. It is also a purpose of the PRG to make information about DOE certification policy and procedures widely available to DOE field offices, DOE contractors, federal agencies, and interested members of the public. 77 refs., 16 figs., 15 tabs

  6. Photo-induced regeneration of hormones by electron transfer processes: Potential biological and medical consequences

    Science.gov (United States)

    Getoff, Nikola; Hartmann, Johannes; Schittl, Heike; Gerschpacher, Marion; Quint, Ruth Maria

    2011-08-01

    Based on the previous results concerning electron transfer processes in biological substances, it was of interest to investigate if hormone transients resulting by e.g. electron emission can be regenerated. The presented results prove for the first time that the hormone transients originating by the electron emission process can be successfully regenerated by the transfer of electrons from a potent electron donor, such as vitamin C (VitC). Investigations were performed using progesterone (PRG), testosterone (TES) and estrone (E1) as representatives of hormones. By irradiation with monochromatic UV light (λ=254 nm) in a media of 40% water and 60% ethanol, the degradation as well as the regeneration of the hormones was studied with each hormone individually and in the mixture with VitC as a function of the absorbed UV dose, using HPLC. Calculated from the obtained initial yields, the determined regeneration of PRG amounted to 52.7%, for TES to 58.6% and for E1 to 90.9%. The consumption of VitC was determined in the same way. The reported results concerning the regeneration of hormones by the transfer of electrons from an electron donor offer a new, promising method for the therapy with hormones. As a consequence of the regeneration of hormones, a decreased formation of carcinogenic metabolites is expected.

  7. Photo-induced regeneration of hormones by electron transfer processes: Potential biological and medical consequences

    Energy Technology Data Exchange (ETDEWEB)

    Getoff, Nikola, E-mail: nikola.getoff@univie.ac.a [Section of Radiation Biology, Faculty of Life Sciences, University of Vienna, A-1090 Vienna (Austria); Hartmann, Johannes [Department of Gynecologic Endocrinology and Reproduction, Medical University of Vienna, A-1090 Vienna (Austria); Schittl, Heike [Section of Radiation Biology, Faculty of Life Sciences, University of Vienna, A-1090 Vienna (Austria); Gerschpacher, Marion [Department of Gynecologic Endocrinology and Reproduction, Medical University of Vienna, A-1090 Vienna (Austria); Quint, Ruth Maria [Section of Radiation Biology, Faculty of Life Sciences, University of Vienna, A-1090 Vienna (Austria)

    2011-08-15

    Based on the previous results concerning electron transfer processes in biological substances, it was of interest to investigate if hormone transients resulting by e.g. electron emission can be regenerated. The presented results prove for the first time that the hormone transients originating by the electron emission process can be successfully regenerated by the transfer of electrons from a potent electron donor, such as vitamin C (VitC). Investigations were performed using progesterone (PRG), testosterone (TES) and estrone (E1) as representatives of hormones. By irradiation with monochromatic UV light ({lambda}=254 nm) in a media of 40% water and 60% ethanol, the degradation as well as the regeneration of the hormones was studied with each hormone individually and in the mixture with VitC as a function of the absorbed UV dose, using HPLC. Calculated from the obtained initial yields, the determined regeneration of PRG amounted to 52.7%, for TES to 58.6% and for E1 to 90.9%. The consumption of VitC was determined in the same way. The reported results concerning the regeneration of hormones by the transfer of electrons from an electron donor offer a new, promising method for the therapy with hormones. As a consequence of the regeneration of hormones, a decreased formation of carcinogenic metabolites is expected.

  8. Photo-induced regeneration of hormones by electron transfer processes: Potential biological and medical consequences

    International Nuclear Information System (INIS)

    Getoff, Nikola; Hartmann, Johannes; Schittl, Heike; Gerschpacher, Marion; Quint, Ruth Maria

    2011-01-01

    Based on the previous results concerning electron transfer processes in biological substances, it was of interest to investigate if hormone transients resulting by e.g. electron emission can be regenerated. The presented results prove for the first time that the hormone transients originating by the electron emission process can be successfully regenerated by the transfer of electrons from a potent electron donor, such as vitamin C (VitC). Investigations were performed using progesterone (PRG), testosterone (TES) and estrone (E1) as representatives of hormones. By irradiation with monochromatic UV light (λ=254 nm) in a media of 40% water and 60% ethanol, the degradation as well as the regeneration of the hormones was studied with each hormone individually and in the mixture with VitC as a function of the absorbed UV dose, using HPLC. Calculated from the obtained initial yields, the determined regeneration of PRG amounted to 52.7%, for TES to 58.6% and for E1 to 90.9%. The consumption of VitC was determined in the same way. The reported results concerning the regeneration of hormones by the transfer of electrons from an electron donor offer a new, promising method for the therapy with hormones. As a consequence of the regeneration of hormones, a decreased formation of carcinogenic metabolites is expected.

  9. The History and Accomplishments of the LIVESTRONG Young Adult Alliance.

    Science.gov (United States)

    Mathews-Bradshaw, Beth; Johnson, Rebecca; Kaplan, Stuart; Craddock, Kelli; Hayes-Lattin, Brandon

    2011-03-01

    This article outlines the history, background, and accomplishments of the LIVESTRONG Young Adult Alliance. The LIVESTRONG Young Adult Alliance, a program of the Lance Armstrong Foundation, was developed as a vehicle for a strategic plan designed to implement the Adolescent and Young Adult Oncology Progress Review Group (AYAO PRG) recommendations. The AYAO PRG was co-sponsored by Lance Armstrong Foundation and the National Cancer Institute (NCI); both LIVESTRONG and NCI provide strategic oversight and guidance to the Alliance. Highlights and accomplishments: The Alliance accomplishments include the publication of disease-specific retrospective analyses, funding of an AYA cohort study and biorepository proposal, publication of two position statements on guidelines for care of AYAs with cancer and training for AYA oncology health professionals, promotion of an international charter of rights for AYA cancer patients, creation and distribution of a survey to college health professionals, creation and implementation of a Cancer Centers Working Group and Institutional Review Board Toolkit, and continued growth and collaboration through an annual meeting. The growth and success of the Alliance has coincided with the growth of AYA oncology as a field. The collaborative environment of the Alliance draws together a diverse group of individuals united in the effort to increase survival rates and improve the quality of life for adolescents and young adults diagnosed with cancer.

  10. Treatment of osteoarthritis using a helper-dependent adenoviral vector retargeted to chondrocytes

    Directory of Open Access Journals (Sweden)

    Merry ZC Ruan

    2016-01-01

    Full Text Available Osteoarthritis (OA is a joint disease characterized by degeneration of the articular cartilage, subchondral bone remodeling, and secondary inflammation. It is among the top three causes of chronic disability, and currently there are no treatment options to prevent disease progression. The localized nature of OA makes it an ideal candidate for gene and cell therapy. However, gene and cell therapy of OA is impeded by inefficient gene transduction of chondrocytes. In this study, we developed a broadly applicable system that retargets cell surface receptors by conjugating antibodies to the capsid of helper-dependent adenoviral vectors (HDVs. Specifically, we applied this system to retarget chondrocytes by conjugating an HDV to an α-10 integrin monoclonal antibody (a10mab. We show that a10mab-conjugated HDV (a10mabHDV-infected chondrocytes efficiently in vitro and in vivo while detargeting other cell types. The therapeutic index of an intra-articular injection of 10mabHDV-expressing proteoglycan 4 (PRG4 into a murine model of post-traumatic OA was 10-fold higher than with standard HDV. Moreover, we show that PRG4 overexpression from articular, superficial zone chondrocytes is effective for chondroprotection in postinjury OA and that α-10 integrin is an effective protein for chondrocyte targeting.

  11. Effectiveness of exercise and protein supplementation intervention on body composition, functional fitness, and oxidative stress among elderly Malays with sarcopenia.

    Science.gov (United States)

    Shahar, Suzana; Kamaruddin, Norshafarina Shari; Badrasawi, Manal; Sakian, Noor Ibrahim Mohamed; Abd Manaf, Zahara; Yassin, Zaitun; Joseph, Leonard

    2013-01-01

    Sarcopenia, characterized as muscle loss that occurs with aging, is a major health problem in an aging population, due to its implications on mobility, quality of life, and fall risk. Protein supplementation could improve the physical fitness by increasing protein anabolism, and exercise has a documented evidence of positive effect on functional status among the elderly. However, the combined effect of both protein supplementation and exercise has not been investigated among sarcopenic elderly in the Asian population. Thus, this study aimed to determine the effectiveness of exercise intervention and protein supplementation either alone or in combination for 12 weeks, on body composition, functional fitness, and oxidative stress among elderly Malays with sarcopenia. Sixty five sarcopenic elderly Malays aged 60-74 years were assigned to the control group, exercise group (ExG), protein supplementation group (PrG), or the combination of exercise and protein supplementation group. A significant interaction effect between body weight and body mass index (BMI) was observed, with the PrG (-2.1% body weight, -1.8% BMI) showing the highest reductions. Further, there was a decrease in % body fat (-4.5%) and an increase in fat-free mass (kg) (+5.7%) in the ExG after 12 weeks (P exercise program was found to improve muscle strength and body composition, while protein supplementation reduced body weight and increased upper body strength, among sarcopenic elderly in Malaysia.

  12. One-particle versus two-particle crossover in weakly coupled Hubbard chains and ladders: perturbative renormalization group approach

    International Nuclear Information System (INIS)

    Kishine, Jun-Ichiro; Yonemitsu, Kenji

    1998-01-01

    Physical nature of dimensional crossovers in weakly coupled Hubbard chains and ladders has been discussed within the framework of the perturbative renormalization-group (PRG) approach. The difference between these two cases originates from different universality classes which the corresponding isolated systems belong to. In the present work, we discuss the nature of the dimensional crossovers in the weakly coupled chains and ladders, with emphasis on the difference between the two cases within the framework of the PRG approach. The difference of the universality class of the isolated chain and ladder profoundly affects the relevance or irrelevance of the inter-chain/ladder one-particle hopping. The strong coupling phase of the isolated ladder makes the one-particle process irrelevant so that the d-wave superconducting transition can be induced via the two-particle crossover in the weakly coupled ladders. The weak coupling phase of the isolated chain makes the one-particle process relevant so that the two-particle crossover can hardly be realized in the coupled chains. (Copyright (1998) World Scientific Publishing Co. Pte. Ltd)

  13. Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.

    Science.gov (United States)

    Barberán-Soler, Sergio; Fontrodona, Laura; Ribó, Anna; Lamm, Ayelet T; Iannone, Camilla; Cerón, Julián; Lehner, Ben; Valcárcel, Juan

    2014-09-25

    Many eukaryotic genes contain embedded antisense transcripts and repetitive sequences of unknown function. We report that male germline-specific expression of an antisense transcript contained in an intron of C. elegans Target of Rapamycin (TOR, let-363) is associated with (1) accumulation of endo-small interfering RNAs (siRNAs) against an embedded Helitron transposon and (2) activation of an alternative 3' splice site of TOR. The germline-specific Argonaute proteins PRG-1 and CSR-1, which participate in self/nonself RNA recognition, antagonistically regulate the generation of these endo-siRNAs, TOR mRNA levels, and 3' splice-site selection. Supply of exogenous double-stranded RNA against the region of sense/antisense overlap reverses changes in TOR expression and splicing and suppresses the progressive multigenerational sterility phenotype of prg-1 mutants. We propose that recognition of a "nonself" intronic transposon by endo-siRNAs/the piRNA system provides physiological regulation of expression and alternative splicing of a host gene that, in turn, contributes to the maintenance of germline function across generations. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  14. The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention

    DEFF Research Database (Denmark)

    Oller Moreno, Sergio; Cominetti, Ornella; Núñez Galindo, Antonio

    2018-01-01

    PURPOSE: The nutritional intervention program "DiOGenes" focuses on how obesity can be prevented and treated from a dietary perspective. We generated differential plasma proteome profiles in the DiOGenes cohort to identify proteins associated with weight loss and maintenance and explore their rel......PURPOSE: The nutritional intervention program "DiOGenes" focuses on how obesity can be prevented and treated from a dietary perspective. We generated differential plasma proteome profiles in the DiOGenes cohort to identify proteins associated with weight loss and maintenance and explore...... with largest changes were sex hormone-binding globulin, adiponectin, C-reactive protein, calprotectin, serum amyloid A, and proteoglycan 4 (PRG4), whose association with obesity and weight loss is known. We identified new putative biomarkers for weight loss/maintenance. Correlation between PRG4 and proline......-rich acidic protein 1 (PRAP1) variation and Matsuda insulin sensitivity increment was showed. CONCLUSIONS AND CLINICAL RELEVANCE: MS-based proteomic analysis of a large cohort of non-diabetic overweight and obese individuals concomitantly identified known and novel proteins associated with weight loss...

  15. Dynamics of initial colonization of nonconserved perennial ryegrass by anaerobic fungi in the bovine rumen.

    Science.gov (United States)

    Edwards, Joan E; Kingston-Smith, Alison H; Jimenez, Hugo R; Huws, Sharon A; Skøt, Kirsten P; Griffith, Gareth W; McEwan, Neil R; Theodorou, Michael K

    2008-12-01

    Anaerobic fungi (Neocallimastigales) are active degraders of fibrous plant material in the rumen. However, only limited information is available relating to how quickly they colonize ingested feed particles. The aim of this study was to determine the dynamics of initial colonization of forage by anaerobic fungi in the rumen and the impact of different postsampling wash procedures used to remove loosely associated microorganisms. Neocallimastigales-specific molecular techniques were optimized to ensure maximal coverage before application to assess the population size (quantitative PCR) and composition (automated ribosomal intergenic spacer analysis) of the colonizing anaerobic fungi. Colonization of perennial ryegrass (PRG) was evident within 5 min, with no consistent effect of time or wash procedure on fungal population composition. Wash procedure had no effect on population size unlike time, which had a significant effect. Colonizing fungal population size continued to increase over the incubation period after an initial lag of c. 4 min. This dynamic differs from that reported previously for rumen bacteria, where substantial colonization of PRG occurred within 5 min. The observed delay in colonization of plant material by anaerobic fungi is suggested to be primarily mediated by the time taken for fungal zoospores to locate, attach and encyst on plant material.

  16. Inter-alpha-trypsin inhibitor heavy chain 4: a novel biomarker for environmental exposure to particulate air pollution in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Lee KY

    2015-04-01

    Full Text Available Kang-Yun Lee,1–3 Po-Hao Feng,1,2 Shu-Chuan Ho,4 Kai-Jen Chuang,5,6 Tzu-Tao Chen,2,3 Chien-Ling Su,2,4 Wen-Te Liu,2,4 Hsiao-Chi Chuang2,4 1Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 2Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, 3Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 4School of Respiratory Therapy, College of Medicine, Taipei Medical University, 5Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, 6School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan Abstract: Chronic obstructive pulmonary disease (COPD is a chronic inflammatory disease that is correlated with environmental stress. Particulate matter ≤10 µm (PM10 is considered to be a risk factor for COPD development; however, the effects of PM10 on the protein levels in COPD remain unclear. Fifty subjects with COPD and 15 healthy controls were recruited. Gene ontology analysis of differentially expressed proteins identified immune system process and binding as the most important biological process and molecular function, respectively, in the responses of PM10-exposed patients with COPD. Biomarkers for PM10 in COPD were identified and compared with the same in healthy controls and included proteoglycan 4 (PRG4, inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4, and apolipoprotein F (APOF. PRG4 and ITIH4 were associated with a past 3-year PM10 exposure level. The receiver operating characteristic curve analysis showed that ITIH4 is a sensitive and specific biomarker for PM10 exposure (area under the curve [AUC] =0.690, P=0.015 compared with PRG4 (AUC =0.636, P=0.083, APOF (AUC =0.523, P=0.766, 8-isoprostane (AUC =0.563, P=0.405, and C-reactive protein (CRP; AUC =0.634, P=0.086. ITIH4 levels were correlated with CRP (r=0

  17. Effectiveness of exercise and protein supplementation intervention on body composition, functional fitness, and oxidative stress among elderly Malays with sarcopenia

    Directory of Open Access Journals (Sweden)

    Shahar S

    2013-10-01

    Full Text Available Suzana Shahar,1 Norshafarina Shari Kamaruddin,2 Manal Badrasawi,1 Noor Ibrahim Mohamed Sakian,3 Zahara Abd Manaf,1 Zaitun Yassin,4 Leonard Joseph51Dietetic Programme, 2Biomedical Programme, 3Occupational Therapy Programme, School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 4Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, 5Department of Physiotherapy, School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, MalaysiaAbstract: Sarcopenia, characterized as muscle loss that occurs with aging, is a major health problem in an aging population, due to its implications on mobility, quality of life, and fall risk. Protein supplementation could improve the physical fitness by increasing protein anabolism, and exercise has a documented evidence of positive effect on functional status among the elderly. However, the combined effect of both protein supplementation and exercise has not been investigated among sarcopenic elderly in the Asian population. Thus, this study aimed to determine the effectiveness of exercise intervention and protein supplementation either alone or in combination for 12 weeks, on body composition, functional fitness, and oxidative stress among elderly Malays with sarcopenia. Sixty five sarcopenic elderly Malays aged 60-74 years were assigned to the control group, exercise group (ExG, protein supplementation group (PrG, or the combination of exercise and protein supplementation group. A significant interaction effect between body weight and body mass index (BMI was observed, with the PrG (-2.1% body weight, -1.8% BMI showing the highest reductions. Further, there was a decrease in % body fat (-4.5% and an increase in fat-free mass (kg (+5.7% in the ExG after 12 weeks (P < 0.05. The highest increments in lower and upper body strength were observed in the PrG

  18. La stesura della procedura generale nell'ambito dell'applicazione della norma UNI EN ISO 9001: 2000 alle direzioni Sanitarie di presidio dell'Azienda Ospedaliera G. Salvini di Garbagnate Milanese

    Directory of Open Access Journals (Sweden)

    A. Ilardo

    2003-05-01

    Full Text Available

    Obiettivi: creare una migliore omogeneizzazione e un linguaggio comune per un modus operandi, dove possibile, univoco tra i diversi Presidi che compongono l’Azienda; fornire il mezzo di confronto e di scambio di informazioni.

    Metodi: il percorso verso la Certificazione ISO 9001:2000 delle Direzioni Sanitarie di Presidio è stato suddiviso in fasi documentali di carattere descrittivo, condivise tra i gruppi di lavoro appositamente costituiti all’interno delle Direzioni, e altre applicative, proprie di ogni Presidio. La stesura della Procedura Generale, iniziata con l’individuazione di tutti i processi lavorativi e con la selezione tra essi di quelli che per primi dovranno essere certificati fa parte della fase documentale. I gruppi di lavoro di ogni Presidio oltre alle riunioni a cui partecipavano solo i rappresentanti per qualità delle tre Direzioni di Presidio sono stati anche coinvolti in incontri estesi ai settori Aziendali già certificati. Scopo di questi ultimi incontri era la presentazione della Vision 2000 e la condivisione di esperienze tra i “certificati e i non certificati”.

    Risultati: un importante risultato della fase documentale è stato l’elaborazione della Procedura Generale/PRG nelle cui pagine sono descritti: lo Scopo e il campo di applicazione; i Riferimenti (Norme e linee Guida di riferimento, Abbreviazioni, Definizioni; Responsabilità; Presentazione e Obiettivi della Direzione Sanitaria; Organigramma dell’Unità; Organizzazione dell’Unità; Descrizione dei processi suddivisi in: Fase, Attività, Documenti del Sistema Qualità; Allegati. Non ultimo va ricordato che la descrizione dei processi nella PRG, facilità l’individuazione di indicatori.

    Conclusioni: la PRG è uno strumento guida, che partendo dall’analisi e dalla revisione dell’Organizzazione da certificare, coinvolge il personale a tutti

  19. More milk from forage: Milk production, blood metabolites, and forage intake of dairy cows grazing pasture mixtures and spatially adjacent monocultures.

    Science.gov (United States)

    Pembleton, Keith G; Hills, James L; Freeman, Mark J; McLaren, David K; French, Marion; Rawnsley, Richard P

    2016-05-01

    There is interest in the reincorporation of legumes and forbs into pasture-based dairy production systems as a means of increasing milk production through addressing the nutritive value limitations of grass pastures. The experiments reported in this paper were undertaken to evaluate milk production, blood metabolite concentrations, and forage intake levels of cows grazing either pasture mixtures or spatially adjacent monocultures containing perennial ryegrass (Lolium perenne), white clover (Trifolium repens), and plantain (Plantago lanceolata) compared with cows grazing monocultures of perennial ryegrass. Four replicate herds, each containing 4 spring-calving, cross-bred dairy cows, grazed 4 different forage treatments over the periods of early, mid, and late lactation. Forage treatments were perennial ryegrass monoculture (PRG), a mixture of white clover and plantain (CPM), a mixture of perennial ryegrass, white clover, and plantain (RCPM), and spatially adjacent monocultures (SAM) of perennial ryegrass, white clover, and plantain. Milk volume, milk composition, blood fatty acids, blood β-hydroxybutyrate, blood urea N concentrations, live weight change, and estimated forage intake were monitored over a 5-d response period occurring after acclimation to each of the forage treatments. The acclimation period for the early, mid, and late lactation experiments were 13, 13, and 10 d, respectively. Milk yield (volume and milk protein) increased for cows grazing the RCPM and SAM in the early lactation experiment compared with cows grazing the PRG, whereas in the mid lactation experiment, milk fat increased for the cows grazing the RCPM and SAM when compared with the PRG treatments. Improvements in milk production from grazing the RCPM and SAM treatments are attributed to improved nutritive value (particularly lower neutral detergent fiber concentrations) and a potential increase in forage intake. Pasture mixtures or SAM containing plantain and white clover could be a

  20. Landslide susceptibility map: from research to application

    Science.gov (United States)

    Fiorucci, Federica; Reichenbach, Paola; Ardizzone, Francesca; Rossi, Mauro; Felicioni, Giulia; Antonini, Guendalina

    2014-05-01

    Susceptibility map is an important and essential tool in environmental planning, to evaluate landslide hazard and risk and for a correct and responsible management of the territory. Landslide susceptibility is the likelihood of a landslide occurring in an area on the basis of local terrain conditions. Can be expressed as the probability that any given region will be affected by landslides, i.e. an estimate of "where" landslides are likely to occur. In this work we present two examples of landslide susceptibility map prepared for the Umbria Region and for the Perugia Municipality. These two maps were realized following official request from the Regional and Municipal government to the Research Institute for the Hydrogeological Protection (CNR-IRPI). The susceptibility map prepared for the Umbria Region represents the development of previous agreements focused to prepare: i) a landslide inventory map that was included in the Urban Territorial Planning (PUT) and ii) a series of maps for the Regional Plan for Multi-risk Prevention. The activities carried out for the Umbria Region were focused to define and apply methods and techniques for landslide susceptibility zonation. Susceptibility maps were prepared exploiting a multivariate statistical model (linear discriminant analysis) for the five Civil Protection Alert Zones defined in the regional territory. The five resulting maps were tested and validated using the spatial distribution of recent landslide events that occurred in the region. The susceptibility map for the Perugia Municipality was prepared to be integrated as one of the cartographic product in the Municipal development plan (PRG - Piano Regolatore Generale) as required by the existing legislation. At strategic level, one of the main objectives of the PRG, is to establish a framework of knowledge and legal aspects for the management of geo-hydrological risk. At national level most of the susceptibility maps prepared for the PRG, were and still are obtained

  1. Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development

    DEFF Research Database (Denmark)

    Jakobsen, L.P.; Borup, R.; Vestergaard, J.

    2009-01-01

    . Moreover, selected differentially expressed genes were analyzed by quantitative RT-PCR, and by immunohistochemical staining of craniofacial tissue from human embryos. Osteopontin (SPP1) and other immune related genes were significantly higher expressed in palate tissue from patients with CLP compared to CP...... and palate (CLP). In order to understand the biological basis in these cleft lip and palate subgroups better we studied the expression profiles in human tissue from patients with CL/P. In each of the CL/P subgroups, samples were obtained from three patients and gene expression analysis was performed...... and immunostaining in palatal shelves against SPP1, chemokine receptor 4 (CXCR4) and serglycin (PRG1) in human embryonic craniofacial tissue were positive, supporting a role for these genes in palatal development. However, gene expression profiles are subject to variations during growth and therefore we recommend...

  2. Preliminary remediation goals for use at the US Department of Energy Oak Ridge Operations Office. Revision 1

    International Nuclear Information System (INIS)

    1996-05-01

    This technical memorandum presents Preliminary Remediation Goals (PRGs) for use in human health risk assessment efforts under the United States Department of Energy, Oak Ridge Operations Office Environmental Restoration (ER) Division. This document provides the ER Division with standardized PRGs which are integral to the Remedial Investigation/Feasibility Study process. They are used during project scooping (Data Quality Objectives development), in screening level risk assessments to support early action or No Further Investigation decisions, and in the baselines risk assessment where they are employed in the selection of chemicals of potential concern. The primary objective of this document is to standardize these values and eliminate any duplication of effort by providing PRGs to all contractors involved in risk activities. In addition, by managing the assumptions and systems used in PRG derivation, the ER Risk Assessment Program will be able to control the level of quality assurance associated with these risk-based guideline values

  3. OECD MCCI project Melt Eruption Test (MET) design report, Rev. 2. April 15, 2003

    International Nuclear Information System (INIS)

    Farmer, M.T.; Lomperski, S.; Kilsdonk, D.J.; Aeschlimann, R.W.; Basu, S.

    2011-01-01

    The Melt Attack and Coolability Experiments (MACE) program at Argonne National Laboratory addressed the issue of the ability of water to cool and thermally stabilize a molten core-concrete interaction when the reactants are flooded from above. These tests provided data regarding the nature of corium interactions with concrete, the heat transfer rates from the melt to the overlying water pool, and the role of noncondensable gases in the mixing processes that contribute to melt quenching. The Melt Coolability and Concrete Interaction (MCCI) program is pursuing separate effect tests to examine the viability of the melt coolability mechanisms identified as part of the MACE program. These mechanisms include bulk cooling, water ingression, volcanic eruptions, and crust breach. At the second PRG meeting held at ANL on 22-23 October 2002, a preliminary design1 for a separate effects test to investigate the melt eruption cooling mechanism was presented for PRG review. At this meeting, NUPEC made several recommendations on the experiment approach aimed at optimizing the chances of achieving a floating crust boundary condition in this test. The principal recommendation was to incorporate a mortar sidewall liner into the test design, since data from the COTELS experiment program indicates that corium does not form a strong mechanical bond with this material. Other recommendations included: (i) reduction of the electrode elevation to well below the melt upper surface elevation (since the crust may bond to these solid surfaces), and (ii) favorably taper the mortar liner to facilitate crust detachment and relocation during the experiment. Finally, as a precursor to implementing these modifications, the PRG recommended the development of a design for a small-scale scoping test intended to verify the ability of the mortar liner to preclude formation of an anchored bridge crust under core-concrete interaction conditions. This revised Melt Eruption Test (MET) plan is intended to

  4. Military Standard Generators Prototype Modifications. Volume 2. 30 kW DoD Generator Set

    Science.gov (United States)

    1988-03-31

    GE14 SET S,./14 KZO 5EJ41 70 KM,,*68 ý0 GEN S¢ET SIRN tɘ 5841 C 1 EXHAUST ± 484.71 DEG. F C I EXHAUST ± 545. 67 DEG. F C 2 EXHAUST 2 473.2-9 DEG. F...584t ý󈧣 Kid.- N Z GE14 SET SoN K20 584 ±i EXHAUST ± 85.64 bEG. F C. EXHAUST 1 062.12 DEG. F C 2 EXHAUSIT 2 75854 PEG.F C 2 EXHAUST 2 7M2± DEG. F c 7...E: 2ŗ GE14 . UVLT. P.RG. 78. 165 DEIG. F AL". C 23 GEN. UDLT. RIG. 69..945 DEG. F AL? C: 24 r:D[4TROL PANEL 68S.7 35% DEG. F ALM! C 24 CO4TRTOL PANEL

  5. In Vitro Evaluation of Beneficial Properties of Bacteriocinogenic Lactobacillus plantarum ST8Sh.

    Science.gov (United States)

    Todorov, Svetoslav Dimitrov; Holzapfel, Wilhelm; Nero, Luis Augusto

    2017-06-01

    Lactobacillus plantarum ST8Sh, isolated from Bulgarian salami "shpek" and previously characterized as bacteriocin producer, was evaluated for its beneficial properties. Based on the PCR analysis, Lb. plantarum ST8Sh was shown to host a gene related to the production of adhesion proteins such as Mab, Mub, EF, and PrgB. Genetic and physiological tests suggest Lb. plantarum ST8Sh to represent a potential probiotic candidate, including survival in the presence of low levels of pH and high levels of ox bile, production of β-galactosidase, bile salt deconjugation, high level of hydrophobicity, functional auto- and co-aggregation properties, and adhesion to cell lines. Application of semi-purified bacteriocin produced by Lb. plantarum ST8Sh in combination with ciprofloxacin presented synergistic effect on inhibition of Listeria monocytogenes Scott A. Based on observed properties, Lb. plantarum ST8Sh can be considered as a potential probiotic candidate with additional bacteriocinogenic properties.

  6. Preliminary remediation goals for use at the US Department of Energy Oak Ridge Operations Office. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    This technical memorandum presents Preliminary Remediation Goals (PRGs) for use in human health risk assessment efforts under the United States Department of Energy, Oak Ridge Operations Office Environmental Restoration (ER) Division. This document provides the ER Division with standardized PRGs which are integral to the Remedial Investigation/Feasibility Study process. They are used during project scooping (Data Quality Objectives development), in screening level risk assessments to support early action or No Further Investigation decisions, and in the baselines risk assessment where they are employed in the selection of chemicals of potential concern. The primary objective of this document is to standardize these values and eliminate any duplication of effort by providing PRGs to all contractors involved in risk activities. In addition, by managing the assumptions and systems used in PRG derivation, the ER Risk Assessment Program will be able to control the level of quality assurance associated with these risk-based guideline values.

  7. PERAWATAN ENDODONTIK KONVENSIONAL PADA GIGI INSISIF LATERAL ATAS DENGAN KISTA RADIKULAR (LAPORAN KASUS

    Directory of Open Access Journals (Sweden)

    Buddiwati Punta

    2015-07-01

    Full Text Available It has been shown that more than 40 percent of the apical radiolucencies are radicular cyst, numerous endodontist claims that from 85 to 90 percent of apical lesions disappear or become reduced in size following conservative endodontic treatment and do not require surgical intervention. Maxillary teeth are more frequently susceptible to trauma and there are numerous morphologic anomalies associated with maxillary incisors especially lateral incisors its call palato-radicular groove (PRG, its caused non vital have been implicated in formation of periapical lesions. Periapical lesions can be cured by conventional endodontic treatment used Ca(OH2 as an intracanal medication. One case with radicular cyst on the maxillary lateral incisors because of trauma 2 years ago will be presented. Fiffteenth months during treatment showed that the cyst reduced in size and symptomless.

  8. A model of synovial fluid lubricant composition in normal and injured joints

    Directory of Open Access Journals (Sweden)

    M E Blewis

    2007-03-01

    Full Text Available The synovial fluid (SF of joints normally functions as a biological lubricant, providing low-friction and low-wear properties to articulating cartilage surfaces through the putative contributions of proteoglycan 4 (PRG4, hyaluronic acid (HA, and surface active phospholipids (SAPL. These lubricants are secreted by chondrocytes in articular cartilage and synoviocytes in synovium, and concentrated in the synovial space by the semi-permeable synovial lining. A deficiency in this lubricating system may contribute to the erosion of articulating cartilage surfaces in conditions of arthritis. A quantitative intercompartmental model was developed to predict in vivo SF lubricant concentration in the human knee joint. The model consists of a SF compartment that (a is lined by cells of appropriate types, (b is bound by a semi-permeable membrane, and (c contains factors that regulate lubricant secretion. Lubricant concentration was predicted with different chemical regulators of chondrocyte and synoviocyte secretion, and also with therapeutic interventions of joint lavage and HA injection. The model predicted steady-state lubricant concentrations that were within physiologically observed ranges, and which were markedly altered with chemical regulation. The model also predicted that when starting from a zero lubricant concentration after joint lavage, PRG4 reaches steady-state concentration ~10-40 times faster than HA. Additionally, analysis of the clearance rate of HA after therapeutic injection into SF predicted that the majority of HA leaves the joint after ~1-2 days. This quantitative intercompartmental model allows integration of biophysical processes to identify both environmental factors and clinical therapies that affect SF lubricant composition in whole joints.

  9. Abnormalities in gray and white matter volumes associated with explicit memory dysfunction in patients with generalized anxiety disorder.

    Science.gov (United States)

    Moon, Chung-Man; Jeong, Gwang-Woo

    2017-03-01

    Background The neuroanatomical abnormalities associated with behavioral dysfunction on explicit memory in patients generalized anxiety disorder (GAD) have not yet been clearly identified. Purpose To investigate the regional gray matter (GM) and white matter (WM) volume alterations over the whole brain in patients with GAD, as well as the correlation between the brain structural abnormality and explicit memory dysfunction. Material and Methods Twenty patients with GAD and 20 healthy controls matched for age, sex, and education level underwent high-resolution T1-weighted magnetic resonance imaging (MRI). The participants performed the explicit memory tasks with the neutral and anxiety-inducing words. Results Patients with GAD showed significantly reduced GM volumes in the midbrain (MB), thalamus, hippocampus (Hip), insula, and superior temporal gyrus (STG); and reduced WM volumes in the MB, anterior limb of the internal capsule (ALIC), dorsolateral prefrontal cortex (DLPFC), and precentral gyrus (PrG). It is important to note that the GM volume of the Hip and the WM volume of the DLPFC were positively correlated with the recognition accuracy (%) in the explicit memory tasks with neutral and anxiety-inducing words, respectively. On the other hand, the WM volume of the PrG was negatively correlated with the reaction time in the same memory tasks. Conclusion This study demonstrated the regional volume changes on whole-brain GM and WM and the correlation between the brain structural alteration and explicit memory dysfunction in GAD patients. These findings would be helpful to understand the association between the brain structure abnormality and the functional deficit in the explicit memory in GAD.

  10. SU-C-207A-05: Feature Based Water Equivalent Path Length (WEPL) Determination for Proton Radiography by the Technique of Time Resolved Dose Measurement

    International Nuclear Information System (INIS)

    Zhang, R; Jee, K; Sharp, G; Flanz, J; Lu, H

    2016-01-01

    Purpose: Studies show that WEPL can be determined from modulated dose rate functions (DRF). However, the previous calibration method based on statistics of the DRF is sensitive to energy mixing of protons due to scattering through different materials (termed as range mixing here), causing inaccuracies in the determination of WEPL. This study intends to explore time-domain features of the DRF to reduce the effect of range mixing in proton radiography (pRG) by this technique. Methods: An amorphous silicon flat panel (PaxScan™ 4030CB, Varian Medical Systems, Inc., Palo Alto, CA) was placed behind phantoms to measure DRFs from a proton beam modulated by a specially designed modulator wheel. The performance of two methods, the previously used method based on the root mean square (RMS) and the new approach based on time-domain features of the DRF, are compared for retrieving WEPL and RSP from pRG of a Gammex phantom. Results: Calibration by T_8_0 (the time point for 80% of the major peak) was more robust to range mixing and produced WEPL with improved accuracy. The error of RSP was reduced from 8.2% to 1.7% for lung equivalent material, with the mean error for all other materials reduced from 1.2% to 0.7%. The mean error of the full width at half maximum (FWHM) of retrieved inserts was decreased from 25.85% to 5.89% for the RMS and T_8_0 method respectively. Monte Carlo simulations in simplified cases also demonstrated that the T_8_0 method is less sensitive to range mixing than the RMS method. Conclusion: WEPL images have been retrieved based on single flat panel measured DRFs, with inaccuracies reduced by exploiting time-domain features as the calibration parameter. The T_8_0 method is validated to be less sensitive to range mixing and can thus retrieve the WEPL values in proximity of interfaces with improved numerical and spatial accuracy for proton radiography.

  11. A genitália externa na tribo Bolboderini (Hemiptera, Reduviidae, Triatominae

    Directory of Open Access Journals (Sweden)

    Herman Lent

    1984-03-01

    Full Text Available Sete espécies da tribo bolboderini, pertencentes aos gêneros Bolbodera, Belminus, Microtriatoma e Parabelminus, duas das quais já encontradas naturalmente infectadas com Trypanosoma cruzi, foram analisadas e comparadas tendo como enfoque oito estruturas da genitália externa dos machos: Processo mediano do pigóforo (PrP, Processo da conjuntiva (PrCj, Extensão mediana da placa basal (EPIb, Processo do endosoma (PrEn, Suporte do falosoma (SPh, Falosoma (Ph, Processo do gonoporo (PrG e a Vesica (V. Microtriatoma trinidadensis (lent, 1951 e M. borbai Lent & Wygodzinsky, 1979 mostraram um plano estrutural morfológico semelhante a Parabelminus yurupucu Lent & Wygodzinsky, 1979 e P. carioca Lent, 1943 e deferindo nitidamente de Belminus peruvianus Herrer, Lent & Wygodzinsky, 1954 e B. herreri Lent & Wygodzinsky, 1979 e de Bolbodera scabrosa, Valdés, 1910, não só pela ausência como pela forma de determinadas estruturas. Estas observações comparativas confirmam as afinidades entre Microtriatoma e Parabelminus e suas relações com belminus e Bolbodera.Seven species of the Bolboderini tribe belonging to the genera bolbodera, Belminus, Microtriatoma and Parabelminus, two of them found naturally infected with Trypanosoma cruzi, were analysed and compared emphasizing eight structures of the male external genitalia: median process of pygophore (PrP, conjunctiva process (PrCj, pedicel (EP1b, endosoma process (PrEn, struts (SPh, phallosoma (Ph, medium bridge (PrG and vesica (V. Microtriatoma trinidadensis (Lent, 1951 and M. borbai Lent & Wygodzinsky, 1979 have shown a structural morphological aspect similar to Parabelminus yurupucu Lent & Wygodzinsky, 1979 and P. carioca Lent, 1943 differing clearly from Belminus peruvianus Herrer, Lent & Wygodzinsky, 1954, B. herreri Lent & Wygodzinsky, 1979 and Bolbodera scabrosa valdés, 1910, not only by the absence but by the shape of some structures. These comparative observations confirm the affinity between

  12. Temporal metagenomic and metabolomic characterisation of fresh perennial ryegrass degradation by rumen bacteria

    Directory of Open Access Journals (Sweden)

    Olga Mayorga

    2016-11-01

    Full Text Available Understanding the relationship between ingested plant material and the attached microbiome is essential for developing methodologies to improve ruminant nutrient use efficiency. We have previously shown that perennial ryegrass (PRG rumen bacterial colonisation events follow a primary (up to 4 h and secondary (after 4 h pattern based on the differences in diversity of the attached bacteria. In this study we investigated temporal niche specialisation of primary and secondary populations of attached rumen microbiota using metagenomic shotgun sequencing as well as monitoring changes in the plant chemistry using mid-infrared spectroscopy (FT-IR. Metagenomic Rapid Annotation using Subsystem Technology (MG-RAST taxonomical analysis of shotgun metagenomic sequences showed that the genera Butyrivibrio, Clostridium, Eubacterium, Prevotella and Selenomonas dominated the attached microbiome irrespective of time. MG-RAST also showed that Acidaminococcus, Bacillus, Butyrivibrio and Prevotella rDNA increased in read abundance during secondary colonisation, whilst Blautia decreased in read abundance. MG-RAST Clusters of Orthologous Groups (COG functional analysis also showed that the primary function of the attached microbiome was categorised broadly within ‘metabolism’; predominantly amino acid, carbohydrate, and lipid metabolism and transport. Most sequence read abundances (51.6, 43.8, and 50.0% of COG families pertaining to amino acid, carbohydrate and lipid metabolism, respectively within these categories were higher in abundance during secondary colonisation. Kyoto encyclopedia of genes and genomes (KEGG pathways analysis confirmed that the PRG- attached microbiota present at 1 and 4 h of rumen incubation possess a similar functional capacity, with only a few pathways being uniquely found in only one incubation time point only. FT-IR data for the plant residues also showed that the main changes in plant chemistry between primary and secondary

  13. Study of new interactions of glitazone's stereoisomers and the endogenous ligand 15d-PGJ2 on six different PPAR gamma proteins.

    Science.gov (United States)

    Álvarez-Almazán, Samuel; Bello, Martiniano; Tamay-Cach, Feliciano; Martínez-Archundia, Marlet; Alemán-González-Duhart, Diana; Correa-Basurto, José; Mendieta-Wejebe, Jessica Elena

    2017-10-15

    Diabetes mellitus is a chronic disease characterized by hyperglycemia, insulin resistance and hyperlipidemia. Glitazones or thiazolidinediones (TZD) are drugs that act as insulin-sensitizing agents whose molecular target is the peroxisome proliferator-activated receptor gamma (PPARγ). The euglycemic action of TZD has been linked with the induction of type 4 glucose transporter. However, it has been shown that the effect of TZD depends on the specific stereoisomer that interacts with PPARγ. Therefore, this work is focused on exploring the interactions and geometry adopted by glitazone's stereoisomers and one endogenous ligand on different conformations of the six crystals of the PPARγ protein using molecular docking and molecular dynamics (MD) simulations accompanied by the MMGBSA approach. Specifically, the 2,4-thiazolidinedione ring, pioglitazone (PIO), rosiglitazone (ROSI) and troglitazone (TRO) stereoisomers (exogenous ligands), as well as the endogenous ligand 15d-PGJ2, were evaluated. The six crystallographic structures of PPARγ are available at Protein Data Bank as the PDB entries 2PRG, 4PRG, 3T03, 1I7I, 1FM6, and 4EMA. According to the results, a boomerang shape and a particular location of ligands were found with low variations according to the protein conformations. The 15d-PGJ2, TZD, PIO, ROSI and (S,S)-TRO enantiomers were mostly stabilized by twenty hydrophobic residues: Phe226, Pro227, Leu228, Ile281, Phe282, Cys285, Ala292, Ile296, Ile326, Tyr327, Met329, Leu330, Leu333, Met334, Val339, Ile341, Met348, Leu353, Phe363 and Met364. Most hydrogen bond interactions were found between the polar groups of ligands with Arg288, Ser289, Lys367, Gln286, His323, Glu343 and His449 residues. An energetic analysis revealed binding free energy trends that supported known experimental findings of other authors describing better binding properties for PIO, ROSI and (S,S)-TRO than for 15d-PGJ2 and the TZD ring. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. 3C 220.3: A radio galaxy lensing a submillimeter galaxy

    Energy Technology Data Exchange (ETDEWEB)

    Haas, Martin; Westhues, Christian; Chini, Rolf [Astronomisches Institut, Ruhr Universität, Bochum (Germany); Leipski, Christian; Klaas, Ulrich; Meisenheimer, Klaus [Max-Planck-Institut für Astronomie, Heidelberg (Germany); Barthel, Peter; Koopmans, Léon V. E. [Kapteyn Astronomical Institute, University of Groningen (Netherlands); Wilkes, Belinda J.; Bussmann, R. Shane; Willner, S. P.; Ashby, Matthew L. N.; Kuraszkiewicz, Joanna [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Vegetti, Simona [Max-Planck-Institut für Astrophysik, Garching (Germany); Clements, David L. [Imperial College, London (United Kingdom); Fassnacht, Christopher D. [University of California, Davis, CA (United States); Horesh, Assaf [Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA (United States); Lagattuta, David J. [Centre for Astrophysics and Supercomputing, Swinburne University of Technology, Hawthorn (Australia); Stern, Daniel; Wylezalek, Dominika, E-mail: haas@astro.rub.de [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA (United States)

    2014-07-20

    Herschel Space Observatory photometry and extensive multiwavelength follow-up have revealed that the powerful radio galaxy (PRG) 3C 220.3 at z = 0.685 acts as a gravitational lens for a background submillimeter galaxy (SMG) at z = 2.221. At an observed wavelength of 1 mm, the SMG is lensed into three distinct images. In the observed near infrared, these images are connected by an arc of ∼1''.8 radius forming an Einstein half-ring centered near the radio galaxy. In visible light, only the arc is apparent. 3C 220.3 is the only known instance of strong galaxy-scale lensing by a PRG not located in a galaxy cluster and therefore it offers the potential to probe the dark matter content of the radio galaxy host. Lens modeling rejects a single lens, but two lenses centered on the radio galaxy host A and a companion B, separated by 1''.5, provide a fit consistent with all data and reveal faint candidates for the predicted fourth and fifth images. The model does not require an extended common dark matter halo, consistent with the absence of extended bright X-ray emission on our Chandra image. The projected dark matter fractions within the Einstein radii of A (1''.02) and B (0''.61) are about 0.4 ± 0.3 and 0.55 ± 0.3. The mass to i-band light ratios of A and B, M/L{sub i}∼8±4 M{sub ⊙} L{sub ⊙}{sup −1}, appear comparable to those of radio-quiet lensing galaxies at the same redshift in the CfA-Arizona Space Telescope LEns Survey, Lenses Structure and Dynamics, and Strong Lenses in the Legacy Survey samples. The lensed SMG is extremely bright with observed f(250 μm) = 440 mJy owing to a magnification factor μ ∼ 10. The SMG spectrum shows luminous, narrow C IV λ1549 Å emission, revealing that the SMG houses a hidden quasar in addition to a violent starburst. Multicolor image reconstruction of the SMG indicates a bipolar morphology of the emitted ultraviolet (UV) light suggestive of cones through which UV light escapes a

  15. The common structural architecture of Shigella flexneri and Salmonella typhimurium type three secretion needles.

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Demers

    2013-03-01

    Full Text Available The Type Three Secretion System (T3SS, or injectisome, is a macromolecular infection machinery present in many pathogenic Gram-negative bacteria. It consists of a basal body, anchored in both bacterial membranes, and a hollow needle through which effector proteins are delivered into the target host cell. Two different architectures of the T3SS needle have been previously proposed. First, an atomic model of the Salmonella typhimurium needle was generated from solid-state NMR data. The needle subunit protein, PrgI, comprises a rigid-extended N-terminal segment and a helix-loop-helix motif with the N-terminus located on the outside face of the needle. Second, a model of the Shigella flexneri needle was generated from a high-resolution 7.7-Å cryo-electron microscopy density map. The subunit protein, MxiH, contains an N-terminal α-helix, a loop, another α-helix, a 14-residue-long β-hairpin (Q51-Q64 and a C-terminal α-helix, with the N-terminus facing inward to the lumen of the needle. In the current study, we carried out solid-state NMR measurements of wild-type Shigella flexneri needles polymerized in vitro and identified the following secondary structure elements for MxiH: a rigid-extended N-terminal segment (S2-T11, an α-helix (L12-A38, a loop (E39-P44 and a C-terminal α-helix (Q45-R83. Using immunogold labeling in vitro and in vivo on functional needles, we located the N-terminus of MxiH subunits on the exterior of the assembly, consistent with evolutionary sequence conservation patterns and mutagenesis data. We generated a homology model of Shigella flexneri needles compatible with both experimental data: the MxiH solid-state NMR chemical shifts and the state-of-the-art cryoEM density map. These results corroborate the solid-state NMR structure previously solved for Salmonella typhimurium PrgI needles and establish that Shigella flexneri and Salmonella typhimurium subunit proteins adopt a conserved structure and orientation in their

  16. Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo

    Science.gov (United States)

    Nakagawa, Yusuke; Muneta, Takeshi; Otabe, Koji; Ozeki, Nobutake; Mizuno, Mitsuru; Udo, Mio; Saito, Ryusuke; Yanagisawa, Katsuaki; Ichinose, Shizuko; Koga, Hideyuki; Tsuji, Kunikazu; Sekiya, Ichiro

    2016-01-01

    Objective Lubricin expression in the superficial cartilage will be a crucial factor in the success of cartilage regeneration. Mesenchymal stem cells (MSCs) are an attractive cell source and the use of aggregates of MSCs has some advantages in terms of chondrogenic potential and efficiency of cell adhesion. Lubricin expression in transplanted MSCs has not been fully elucidated so far. Our goals were to determine (1) whether cartilage pellets of human MSCs expressed lubricin in vitro chondrogenesis, (2) whether aggregates of human MSCs promoted lubricin expression, and (3) whether aggregates of MSCs expressed lubricin in the superficial cartilage after transplantation into osteochondral defects in rats. Methods For in vitro analysis, human bone marrow (BM) MSCs were differentiated into cartilage by pellet culture, and also aggregated using the hanging drop technique. For an animal study, aggregates of BM MSCs derived from GFP transgenic rats were transplanted to the osteochondral defect in the trochlear groove of wild type rat knee joints. Lubricin expression was mainly evaluated in differentiated and regenerated cartilages. Results In in vitro analysis, lubricin was detected in the superficial zone of the pellets and conditioned medium. mRNA expression of Proteoglycan4 (Prg4), which encodes lubricin, in pellets was significantly higher than that of undifferentiated MSCs. Aggregates showed different morphological features between the superficial and deep zone, and the Prg4 mRNA expression increased after aggregate formation. Lubricin was also found in the aggregate. In a rat study, articular cartilage regeneration was significantly better in the MSC group than in the control group as shown by macroscopical and histological analysis. The transmission electron microscope showed that morphology of the superficial cartilage in the MSC group was closer to that of the intact cartilage than in the control group. GFP positive cells remained in the repaired tissue and

  17. The strategic plan for the Committee on the Safety of Nuclear Installations

    International Nuclear Information System (INIS)

    2000-01-01

    Following the request from the NEA that all the committees should develop Strategic Plans and the report of the Effectiveness Review Group (ERG) on the effectiveness of CSNI's activities, CSNI created a Strategic Planning Group to review their working processes. In developing a five year rolling Strategic Plan, the Group has considered the need for more top-down direction by CSNI, stricter control on time limited Task Groups and improved communications including timely review and publication of reports. The Strategic Planning Group, after reviewing the current work structure of CSNI and the current technical issues as laid out in the SESAR series of reports and the CNRA report on Regulatory Effectiveness, have made the following recommendations. The basic elements of the CSNI will continue to be the Principal Working Groups, which will be known in future simply as Working Groups. The number of Working Groups and their areas of expertise will be reviewed periodically when the strategic plan undergoes a review. It is recommended that this Plan be reviewed every five years. In order to provide better top-down direction by the CSNI, it is recommended that a small Programme Review Group (PRG) be created. The PRG will assist the CSNI Bureau to review proposals from the Working Groups, and enable the review of major reports to ensure high quality. To ensure timely management of projects and reviews of proposals and reports it is recommended that CSNI have a second full meeting in early summer. It is recommended that Special Expert Groups (SEGs) be created reporting directly to CSNI. These Groups would deal with issues that cut across the disciplines of more than one Working Group and be assigned clear time-limited mandates. The creation of SEGs on Fuel Safety Margins and on Human and Organisational Factors is proposed at this time. Restructuring of the five Principal Working Groups into four Working Groups is recommended. This would be accomplished by merging the former

  18. Epigenome-wide DNA methylation study of IgE concentration in relation to self-reported allergies.

    Science.gov (United States)

    Ek, Weronica E; Ahsan, Muhammad; Rask-Andersen, Mathias; Liang, Liming; Moffatt, Miriam F; Gyllensten, Ulf; Johansson, Åsa

    2017-04-01

    Epigenetic mechanisms are critical for normal immune development and epigenetic alterations might therefore be possible contributors to immune diseases. To investigate if DNA methylation in whole blood is associated with total and allergen-specific IgE levels. We performed an epigenome-wide association study to investigate the association between DNA methylation and IgE level, allergen-specific IgE and self-reported immune diseases and allergies in 728 individuals. We identified and replicated 15 CpG sites associated with IgE, mapping to biologically relevant genes, including ACOT7, ILR5A, KCNH2, PRG2 and EPX. A total of 331 loci were associated with allergen-specific IgE, but none of these CpG sites were associated with self-reported allergies and immune diseases. This study shows that IgE levels are associated with DNA methylation levels at numerous CpG sites, which might provide new leads for investigating the links between IgE and allergic inflammation.

  19. Screening-level ecological and human health risk assessment of polycyclic aromatic hydrocarbons in stormwater detention pond sediments of Coastal South Carolina, USA

    Energy Technology Data Exchange (ETDEWEB)

    Weinstein, John E., E-mail: john.weinstein@citadel.edu [Department of Biology, The Citadel, Charleston, SC (United States); Crawford, Kevin D. [Department of Chemistry, University of Wisconsin-Oshkosh, Oshkosh, WI (United States); Garner, Thomas R. [Institute of Environmental Toxicology, Clemson University, Pendleton, SC (United States); Flemming, Alan J. [South Carolina Department of Health and Environmental Control, Charleston, SC (United States)

    2010-06-15

    Screening-level ecological and human health assessments were performed for polycyclic aromatic hydrocarbon (PAH) contamination in the sediments of 19 stormwater detention ponds located in coastal South Carolina. For ecological screening benchmarks, we used threshold and probable effect concentrations (TEC and PEC) derived from consensus-based sediment quality guidelines for individual PAH analytes and equilibrium partitioning sediment benchmarks-toxic units ({Sigma}ESB-TU) derived for PAH mixtures. For human health benchmarks, we used preliminary remediation goals (PRGs). Sediments of five stormwater ponds (four commercial ponds and one residential pond with a large drainage area) exceeded PEC values for several PAH analytes and the {Sigma}ESB-TU safe value of 1 for PAH mixtures. These same five stormwater ponds also exceeded the PRG values for five carcinogenic PAH analytes. These results suggest that the PAH levels in sediments from certain commercial and residential ponds have the potential to pose moderate to high risks for adverse, chronic effects to benthic organisms in situ and an increased risk of cancer to humans ex situ following excavation and on-site disposal. We recommend that sediment from these stormwater ponds be tested prior to excavation to determine the appropriate method of disposal. We also recommend that regulatory agencies enforce guidelines for periodic sediment removal as this should reduce both in situ and ex situ risks resulting from sediment PAH exposure.

  20. Screening-level ecological and human health risk assessment of polycyclic aromatic hydrocarbons in stormwater detention pond sediments of Coastal South Carolina, USA

    International Nuclear Information System (INIS)

    Weinstein, John E.; Crawford, Kevin D.; Garner, Thomas R.; Flemming, Alan J.

    2010-01-01

    Screening-level ecological and human health assessments were performed for polycyclic aromatic hydrocarbon (PAH) contamination in the sediments of 19 stormwater detention ponds located in coastal South Carolina. For ecological screening benchmarks, we used threshold and probable effect concentrations (TEC and PEC) derived from consensus-based sediment quality guidelines for individual PAH analytes and equilibrium partitioning sediment benchmarks-toxic units (ΣESB-TU) derived for PAH mixtures. For human health benchmarks, we used preliminary remediation goals (PRGs). Sediments of five stormwater ponds (four commercial ponds and one residential pond with a large drainage area) exceeded PEC values for several PAH analytes and the ΣESB-TU safe value of 1 for PAH mixtures. These same five stormwater ponds also exceeded the PRG values for five carcinogenic PAH analytes. These results suggest that the PAH levels in sediments from certain commercial and residential ponds have the potential to pose moderate to high risks for adverse, chronic effects to benthic organisms in situ and an increased risk of cancer to humans ex situ following excavation and on-site disposal. We recommend that sediment from these stormwater ponds be tested prior to excavation to determine the appropriate method of disposal. We also recommend that regulatory agencies enforce guidelines for periodic sediment removal as this should reduce both in situ and ex situ risks resulting from sediment PAH exposure.

  1. Phenotypic and genotypic antimicrobial resistance and virulence genes of Salmonella enterica isolated from pet dogs and cats

    Science.gov (United States)

    Srisanga, Songsak; Angkititrakul, Sunpetch; Sringam, Patcharee; Le Ho, Phuong T.; Vo, An T. T.

    2017-01-01

    Salmonella enterica isolates (n = 122), including 32 serotypes from 113 dogs and 9 cats, were obtained from household dogs (n = 250) and cats (n = 50) during 2012–2015. The isolates were characterized by serotyping, antimicrobial resistance phenotyping and genotyping, and virulence gene screening. Serovars Weltevreden (15.6%) and Typhimurium (13.9%) were the most common. The majority (43%) of the isolates were multidrug resistant. The dog isolates (12.3%) harbored class 1 integrons, of which the dfrA12-aadA2 cassette was most frequent (66.7%). The only class integron in serovar Albany was located on a conjugative plasmid. Two ESBL-producing isolates (i.e., a serovar Krefeld and a serovar Enteritridis) carried blaTEM and blaCTX-M, and the blaTEM gene in both was horizontally transferred. Of the plasmid-mediated quinolone resistance genes tested, only qnrS (4.9%) was detected. Most Salmonella isolates harbored invA (100%), prgH (91.8%), and sipB (91%). Positive associations between resistance and virulence genes were observed for blaPSE-1/orgA, cmlA/spaN, tolC, and sul1/tolC (p resistance and virulence genes and that antimicrobial use in companion animals may select for the examined Salmonella virulence factors. PMID:27586467

  2. Enhancing wear resistance of working bodies of grinder through lining crushed material

    Science.gov (United States)

    Romanovich, A. A.; Annenko, D. M.; Romanovich, M. A.; Apukhtina, I. V.

    2018-03-01

    The article presents the analysis of directions of increasing wear resistance of working surfaces of rolls. A technical solution developed at the level of the invention is proposed, which is simple to implement in production conditions and which makes it possible to protect the roll surface from heavy wear due to surfacing of wear-resistant mesh material, cells of which are filling with grinding material in the process of work. Retaining them enables one to protect the roll surface from wear. The paper dwells on conditions of pressing materials in cells of eccentric rolls on the working surface with a grid of rectangular shape. The paper presents an equation for calculation of the cell dimension that provides the lining of the working surface by a mill material with respect to its properties. The article presents results of comparative studies on the grinding process of a press roller grinder (PRG) between rolls with and without a fusion-bonded mesh. It is clarified that the lining of rolls working surface slightly reduces the quality of the grinding, since the material thickness in the cell is small and has a finely divided and compacted structure with high strength.

  3. Multitemporal analysis of the change of earth covering; high basin Guatiquia River - Low Sector

    International Nuclear Information System (INIS)

    Prieto Gonzalez, Jose Luis

    1999-01-01

    One of the basic functions inside the environmental administration has been the record of the variables of the natural environment. The earth covering corresponds to one of the elements that to the registered being and analyzed, shows with more fidelity the evolution of the environment. At the present time, and from their creation in 1992, the project Guatiquia River - PRG that covers 90.000 approximately has. Located between the Cundinamarca and Meta Departments, it has looked for to obtain the necessary technical elements to achieve a sustainable handling in the area, for it, it intended to be ahead a study that allows to quantify and to analyze the changes of the earth covering, reason for which, it was ahead the present study: multitemporal analysis of the change of earth covering high basin of the Guatiquia River low sector, for a total surface of 13997.64 hectares (corresponding to 15.8% of the area of action of the Project Guatiquia River), and having as basic tools the remote perception and the geographical information systems, it was carried out the prosecution of the information of earth covering in the study area for the years 1993 and 1997 starting from which, were determined and analyzed the changes of earth covering, they were presented in cartographic documents to scale 1:25.000, corresponding to a detailed study

  4. The lower limiting values of collector properties based on core data

    Energy Technology Data Exchange (ETDEWEB)

    Mitrofanov, V P; Tul' bovich, B I

    1982-01-01

    There are numerous methods for determining the lower limiting values of collector properties; which is caused by complexity of studying objects, the utilization of different petrophysical parameters and characteristics of formation productiveness. Based on laboratory studies conducted at PermNIPIneft', two methods of determining the limited values of collector properties were examined with consideration of data from existing literature: 1) from the critical water saturation content K /SUB b/ *; 2) using the phase permeability for kerosene or oil K /SUB prk/. In the first case the value of K /SUB b/ * is determined from the presence of filtering of a two-face flow with the oil fraction not less than 2%. Knowing the value of K /SUB b/ *, the limiting values of collector properties are evaluated by using the petrophysical relationships, which reflect the connection between residual water saturation, permeability for a gas, porosity, the complex parameter ..sqrt.. K /SUB prg/ /K /SUB p/, and also by the effective porosity. In the second case determination of the phase permeability K /SUB prk/ for collectors with low permeability allows one to establish limiting values of collector properties of permeability. Transition to the porosity limit is achieved by the relationship of gas permeability to open or effective porosity. The examining methods for determining lower limiting values of collector properties are used in calculating the reserve of 9 deposits in the Permian region.

  5. Analysis of lipid experiments (ALEX: a software framework for analysis of high-resolution shotgun lipidomics data.

    Directory of Open Access Journals (Sweden)

    Peter Husen

    Full Text Available Global lipidomics analysis across large sample sizes produces high-content datasets that require dedicated software tools supporting lipid identification and quantification, efficient data management and lipidome visualization. Here we present a novel software-based platform for streamlined data processing, management and visualization of shotgun lipidomics data acquired using high-resolution Orbitrap mass spectrometry. The platform features the ALEX framework designed for automated identification and export of lipid species intensity directly from proprietary mass spectral data files, and an auxiliary workflow using database exploration tools for integration of sample information, computation of lipid abundance and lipidome visualization. A key feature of the platform is the organization of lipidomics data in "database table format" which provides the user with an unsurpassed flexibility for rapid lipidome navigation using selected features within the dataset. To demonstrate the efficacy of the platform, we present a comparative neurolipidomics study of cerebellum, hippocampus and somatosensory barrel cortex (S1BF from wild-type and knockout mice devoid of the putative lipid phosphate phosphatase PRG-1 (plasticity related gene-1. The presented framework is generic, extendable to processing and integration of other lipidomic data structures, can be interfaced with post-processing protocols supporting statistical testing and multivariate analysis, and can serve as an avenue for disseminating lipidomics data within the scientific community. The ALEX software is available at www.msLipidomics.info.

  6. Analysis of lipid experiments (ALEX): a software framework for analysis of high-resolution shotgun lipidomics data.

    Science.gov (United States)

    Husen, Peter; Tarasov, Kirill; Katafiasz, Maciej; Sokol, Elena; Vogt, Johannes; Baumgart, Jan; Nitsch, Robert; Ekroos, Kim; Ejsing, Christer S

    2013-01-01

    Global lipidomics analysis across large sample sizes produces high-content datasets that require dedicated software tools supporting lipid identification and quantification, efficient data management and lipidome visualization. Here we present a novel software-based platform for streamlined data processing, management and visualization of shotgun lipidomics data acquired using high-resolution Orbitrap mass spectrometry. The platform features the ALEX framework designed for automated identification and export of lipid species intensity directly from proprietary mass spectral data files, and an auxiliary workflow using database exploration tools for integration of sample information, computation of lipid abundance and lipidome visualization. A key feature of the platform is the organization of lipidomics data in "database table format" which provides the user with an unsurpassed flexibility for rapid lipidome navigation using selected features within the dataset. To demonstrate the efficacy of the platform, we present a comparative neurolipidomics study of cerebellum, hippocampus and somatosensory barrel cortex (S1BF) from wild-type and knockout mice devoid of the putative lipid phosphate phosphatase PRG-1 (plasticity related gene-1). The presented framework is generic, extendable to processing and integration of other lipidomic data structures, can be interfaced with post-processing protocols supporting statistical testing and multivariate analysis, and can serve as an avenue for disseminating lipidomics data within the scientific community. The ALEX software is available at www.msLipidomics.info.

  7. Identification of phosphoproteins coupled to initiation of motility in live epididymal mouse sperm

    Science.gov (United States)

    Tash, J. S.; Bracho, G. E.

    1998-01-01

    A method for collecting live immotile cauda epididymal mouse sperm that initiate motility by dilution into an activation buffer is described. Sperm in collection buffer showed low percent motility (MOT) and population progression (PRG) that increased 10-fold and 9-fold, respectively, during the first 2 min after dilution into activation buffer. Western phosphoserine (pS), phosphothreonine (pT), and phosphotyrosine (pY) analysis revealed a 120 kDa protein that markedly increased in pT content during initiation of motility and may be related to FP130, the motility-coupled axonemal protein of sea urchin sperm. A prominent 82 kDa protein that was pS and pT-phosphorylated in immotile and motile sperm is likely the fibrous sheath component AKAP82 that is phosphorylated during spermatogenesis. Analysis of live human sperm also identified a prominent 120 kDa pT protein. Thus it appears that phosphorylation of FP130 and related 120 kDa proteins in mouse, and perhaps human sperm, represent common targets during motility initiation in sperm. Copyright 1998 Academic Press.

  8. Maximizing the sensitivity and reliability of peptide identification in large-scale proteomic experiments by harnessing multiple search engines.

    Science.gov (United States)

    Yu, Wen; Taylor, J Alex; Davis, Michael T; Bonilla, Leo E; Lee, Kimberly A; Auger, Paul L; Farnsworth, Chris C; Welcher, Andrew A; Patterson, Scott D

    2010-03-01

    Despite recent advances in qualitative proteomics, the automatic identification of peptides with optimal sensitivity and accuracy remains a difficult goal. To address this deficiency, a novel algorithm, Multiple Search Engines, Normalization and Consensus is described. The method employs six search engines and a re-scoring engine to search MS/MS spectra against protein and decoy sequences. After the peptide hits from each engine are normalized to error rates estimated from the decoy hits, peptide assignments are then deduced using a minimum consensus model. These assignments are produced in a series of progressively relaxed false-discovery rates, thus enabling a comprehensive interpretation of the data set. Additionally, the estimated false-discovery rate was found to have good concordance with the observed false-positive rate calculated from known identities. Benchmarking against standard proteins data sets (ISBv1, sPRG2006) and their published analysis, demonstrated that the Multiple Search Engines, Normalization and Consensus algorithm consistently achieved significantly higher sensitivity in peptide identifications, which led to increased or more robust protein identifications in all data sets compared with prior methods. The sensitivity and the false-positive rate of peptide identification exhibit an inverse-proportional and linear relationship with the number of participating search engines.

  9. Combining Search Engines for Comparative Proteomics

    Science.gov (United States)

    Tabb, David

    2012-01-01

    Many proteomics laboratories have found spectral counting to be an ideal way to recognize biomarkers that differentiate cohorts of samples. This approach assumes that proteins that differ in quantity between samples will generate different numbers of identifiable tandem mass spectra. Increasingly, researchers are employing multiple search engines to maximize the identifications generated from data collections. This talk evaluates four strategies to combine information from multiple search engines in comparative proteomics. The “Count Sum” model pools the spectra across search engines. The “Vote Counting” model combines the judgments from each search engine by protein. Two other models employ parametric and non-parametric analyses of protein-specific p-values from different search engines. We evaluated the four strategies in two different data sets. The ABRF iPRG 2009 study generated five LC-MS/MS analyses of “red” E. coli and five analyses of “yellow” E. coli. NCI CPTAC Study 6 generated five concentrations of Sigma UPS1 spiked into a yeast background. All data were identified with X!Tandem, Sequest, MyriMatch, and TagRecon. For both sample types, “Vote Counting” appeared to manage the diverse identification sets most effectively, yielding heightened discrimination as more search engines were added.

  10. Use of Noninvasive Ventilation During Feeding Tube Placement.

    Science.gov (United States)

    Banfi, Paolo; Volpato, Eleonora; Valota, Chiara; D'Ascenzo, Salvatore; Alunno, Chiara Bani; Lax, Agata; Nicolini, Antonello; Ticozzi, Nicola; Silani, Vincenzo; Bach, John R

    2017-11-01

    Parenteral nutrition is indicated in amyotrophic lateral sclerosis (ALS) when dysphagia, loss of appetite, and difficulty protecting the airways cause malnutrition, severe weight loss, dehydration, and increased risk of aspiration pneumonia. The aim of this review is to compare percutaneous endoscopic gastrostomy (PEG), radiologically inserted G-tube (RIG), and percutaneous radiologic gastrostomy (PRG) in patients with ALS, performed with or without noninvasive ventilation (NIV). We searched PubMed, MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), the EBSCO Online Research Database, and Scopus up to December 2015. A priori selection included all randomized controlled trials (RCTs), quasi-randomized trials, and prospective and retrospective studies. The primary outcome was 30-d survival. We found no RCTs or quasi-RCTs. Seven studies about the implementation of the PEG/RIG procedure during the use of NIV and 5 studies without NIV were included. In another study of 59 subjects undergoing open gastrostomy, all with vital capacity NIV at full ventilatory support settings, there were no respiratory complications. Thus, the use of NIV during the implementation of these procedures, especially when used at full ventilatory support settings of pressure preset 18-25 cm H 2 O, can support alveolar ventilation before, during, and after the procedures and prevent respiratory complications. The procedures investigated appear equivalent, but the methodological quality of the studies could be improved. Possible benefits with regard to nutrition parameters, quality of life, and psychological features need to be further investigated. Copyright © 2017 by Daedalus Enterprises.

  11. FPGA platform for MEMS Disc Resonance Gyroscope (DRG) control

    Science.gov (United States)

    Keymeulen, Didier; Peay, Chris; Foor, David; Trung, Tran; Bakhshi, Alireza; Withington, Phil; Yee, Karl; Terrile, Rich

    2008-04-01

    Inertial navigation systems based upon optical gyroscopes tend to be expensive, large, power consumptive, and are not long lived. Micro-Electromechanical Systems (MEMS) based gyros do not have these shortcomings; however, until recently, the performance of MEMS based gyros had been below navigation grade. Boeing and JPL have been cooperating since 1997 to develop high performance MEMS gyroscopes for miniature, low power space Inertial Reference Unit applications. The efforts resulted in demonstration of a Post Resonator Gyroscope (PRG). This experience led to the more compact Disc Resonator Gyroscope (DRG) for further reduced size and power with potentially increased performance. Currently, the mass, volume and power of the DRG are dominated by the size of the electronics. This paper will detail the FPGA based digital electronics architecture and its implementation for the DRG which will allow reduction of size and power and will increase performance through a reduction in electronics noise. Using the digital control based on FPGA, we can program and modify in real-time the control loop to adapt to the specificity of each particular gyro and the change of the mechanical characteristic of the gyro during its life time.

  12. The U.S. Department of Energy SARP review training program

    International Nuclear Information System (INIS)

    Mauck, C.J.

    1988-01-01

    In support of its radioactive material packaging certification program, the U.S. Department of Energy (DOE) has established a special training workshop. The purpose of the two-week workshop is to develop skills in reviewing Safety Analysis Reports for Packagings (SARPs) and performing confirmatory analyses. The workshop, conducted by the Lawrence Livermore National Laboratory (LLNL) for DOE, is divided into two parts: methods of review and methods of analysis. The sessions covering methods of review are based on the DOE document, ''Packaging Review Guide for Reviewing Safety Analysis Reports for Packagings'' (PRG). The sessions cover relevant DOE Orders and all areas of review in the applicable Nuclear Regulatory Commission (NRC) Regulatory Guides. The technical areas addressed include structural and thermal behavior, materials, shielding, criticality, and containment. The course sessions on methods of analysis provide hands-on experience in the use of calculational methods and codes for reviewing SARPs. Analytical techniques and computer codes are discussed and sample problems are worked. Homework is assigned each night and over the included weekend; at the conclusion, a comprehensive take-home examination is given requiring six to ten hours to complete

  13. Differential involvement of corticospinal tract (CST fibers in UMN-predominant ALS patients with or without CST hyperintensity: A diffusion tensor tractography study

    Directory of Open Access Journals (Sweden)

    Venkateswaran Rajagopalan

    2017-01-01

    DTT revealed subcortical loss ('truncation' of virtual motor CST fibers (presumably projecting from the precentral gyrus (PrG in ALS patients but not in controls; in contrast, virtual fibers (presumably projecting to the adjacent postcentral gyrus (PoG were spared. No significant differences in virtual CST fiber length were observed between controls and ALS patients. However, the frequency of CST truncation was significantly higher in the ALS-CST+ subgroup (9 of 21 than in the ALS-CST− subgroup (4 of 24; p = 0.049, suggesting this finding could differentiate these ALS subgroups. Also, because virtual CST truncation occurred only in the ALS patient group and not in the control group (p = 0.018, this DTT finding could prove to be a diagnostic biomarker of ALS. Significantly shorter disease duration and faster disease progression rate were observed in ALS patients with CST fiber truncation than in those without (p  0.05 in any of the ROIs. In addition, comparing FA values between ALS patients with CST truncation and those without in the aforementioned four ROIs, revealed no significant differences in either hemisphere. However, visual evaluation of DTT was able to identify UMN degeneration in patients with ALS, particularly in those with a more aggressive clinical disease course and possibly different pathologic processes.

  14. IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells.

    Science.gov (United States)

    Hashiguchi, Masaaki; Kashiwakura, Yuji; Kojima, Hidefumi; Kobayashi, Ayano; Kanno, Yumiko; Kobata, Tetsuji

    2015-03-01

    Eosinophils are multifunctional leukocytes involved in allergic reactions as well as adipose tissue regulation. IL-5 is required for eosinophil survival; however, the in vivo mechanisms of eosinophil regulation are not fully understood. A tg mouse model with il5 promoter-driven EGFP expression was established for detecting the IL-5-producing cells in vivo. Il5-egfp tg mice expressed high levels of EGFP in gonadal adipose tissue (GAT) cells. EGFP(+) cells in GAT were mainly group 2 innate lymphoid cells (ILCs). IL-33 preferentially expanded EGFP(+) cells and eosinophils in GAT in vivo. EGFP(+) ILCs were found to upregulate prg2 mRNA expression in GAT eosinophils. These results demonstrate that ILCs activate eosinophils in GAT. The blockage of IL-33Rα, on the other hand, did not impair EGFP(+) ILC numbers but did impair eosinophil numbers in vivo. GAT eosinophils expressed IL-33Rα and IL-33 expanded eosinophil numbers in CD90(+) cell-depleted mice. IL-33 was further observed to induce the expression of retnla and epx mRNA in eosinophils. These findings demonstrate that IL-33 directly activates eosinophils in GAT, and together with our other findings described above, our findings show that IL-33 has dual pathways via which it activates eosinophils in vivo: a direct activation pathway and a group 2 ILC-mediated pathway. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Effects of polishing on surface roughness, gloss and color of surface reaction type pre-reacted glass-ionomer filled resin composite.

    Science.gov (United States)

    Hosoya, Yumiko; Shiraishi, Takanobu; Odatsu, Tetsuro; Miyazaki, Masashi; García-Godoy, Franklin

    2011-06-01

    To evaluate the effects of polishing on surface roughness, gloss and color of different shades of surface reaction type pre-reacted glass-ionomer (S-PRG) filled nano-hybrid resin composite. Resin disks of 15 mm diameter and 2 mm thickness and final polish with 1000-grit SiC paper, super fine cut diamond (FG) point, silicon (MFR) point and Super-Snap mini-disk red (SNAP) were made with Beautifil II shades: A2, A20, Inc). One week after curing, the surface roughness, gloss and color were measured. Data was analyzed with ANOVA and Fisher's PLSD with alpha= 0.05 For all shades, the order of roughness (Ra) ranked according to groups of 1000-grit SiC > FG > MFR > SNAP with significant differences among all groups. For all shades, the order of gloss ranked according to groups of SNAP > MFR > FG > 1000-grit SiC with significant differences among the groups except for between MFR and FG without significant difference. The influence of the surface roughness on color differed among the polishing groups and shades. However, the values of the color differences (deltaE*ab) between the polishing groups of all shades were imperceptible to the naked eye.

  16. Development of design Criteria for ITER In-vessel Components

    International Nuclear Information System (INIS)

    Sannazzaro, G.; Barabash, V.; Kang, S.C.; Fernandez, E.; Kalinin, G.; Obushev, A.; Martínez, V.J.; Vázquez, I.; Fernández, F.; Guirao, J.

    2013-01-01

    Absrtract: The components located inside the ITER vacuum chamber (in-vessel components – IC), due to their specific nature and the environments they are exposed to (neutron radiation, high heat fluxes, electromagnetic forces, etc.), have specific design criteria which are, in this paper, referred as Structural Design Criteria for In-vessel Components (SDC-IC). The development of these criteria started in the very early phase of the ITER design and followed closely the criteria of the RCC-MR code. Specific rules to include the effect of neutron irradiation were implemented. In 2008 the need of an update of the SDC-IC was identified to add missing specifications, to implement improvements, to modernise rules including recent evolutions in international codes and regulations (i.e. PED). Collaboration was set up between ITER Organization (IO), European (EUDA) and Russian Federation (RFDA) Domestic Agencies to generate a new version of SDC-IC. A Peer Review Group (PRG) composed by members of the ITER Organization and all ITER Domestic Agencies and code experts was set-up to review the proposed modifications, to provide comments, contributions and recommendations

  17. Mastimännid ja muu mets : mitmekülgsuse võlu Eesti proosast aastal 2007 / Sirje Olesk

    Index Scriptorium Estoniae

    Olesk, Sirje, 1954-

    2008-01-01

    Ülevaade 2007. aasta eesti proosast. Käsitletakse järgimisi autoreid ja nende teoseid: Ene Mihkelson "Katkuhaud", Andrus Kivirähk "Mees, kes teadis ussisõnu", Jaan Kaplinski "Seesama jõgi", Tõnu Õnnepalu "Flandria päevik", Toomas Vint "Mäluauguga naine", Indrek Hargla "French ja Koulu Tarbatus", Kalle Käsper "Buridanid IV", Jaan Tooming "Teekond mäe südamesse", Ustav Mikelsaar "Tunnimehed", Henn Mikelsaar "Teema variatsioonidega", Reet Kudu "Pidupäevad võõrsil", Mara Maret Aronovich "Tagasikäiguga edasi", Aimée Beekman "Proovielu", Valentine Nõlvak "Ellujääja : mälestused", Mehis Heinsaar "Rändaja õnn", Maimu Berg "Unustatud inimesed", Mats Traat "Sarviku armastus : valik kultuuriloolisi novelle", Mihkel Mutt "Siseemigrant : novellid Rui taevalike kommentaaridega", Paavo Kivine "Kaks kavaleri", Kärt Hellerma "Ma armastasin David Copperfieldi", Piret Bristol "Paralleelmeri", Imre Siil "Mereröövlite loss", Kalju Saaber "Issanda loomaaed. Viru sektor", Veiko Märka "Lendas üle marmortahvli", Vahur Afanasjev "Kaadrid otsustavad, ehk, Sööbik ja Pisik seiklevad jälle, ehk, Eesti rahva lühike, kuid õnnelik ajalugu, Ehk kirjalik komejant tühjusest", Aarne Ruuben "Lugusid Anveltist ja Kingissepast", Epp Annus "Sina, Matilda", Peeter Helme "Puudutus", Ivar Sild "Tantsiv linn", Tui Hirv "Tähe tänav. Per musica ad astra", Tiina Laanem "Väikesed vanamehed", Angela Hofberg (pseud.) "Päev nagu elu", Marion Andra "Vähemalt...", Olle Lauli "Niguliste õpilased", Aarne Biin "Linna valitsemine", Erik Tohvri "Mürgiliblikas", Riina Kangur "Elisa", Kerttu Rakke "Küpsiseparadiis", Epp Petrone ja Dagmar Reintam "Õun ära süüa?", Elme Väljaste "Päriselu Proletariaadi puiesteel", Ketlin Priilinn "Hõbeingel", Ira Lember "Kohvik pärnade all", Paul Pajos "Krimijutud edasijõudnuile", Andres Anvelt "Punane elavhõbe", Klaara ja Kaarel Kivi "Mõrvasügis", Tiit Sepa "Hommik ühele", Lembit Uustulnd "Ruutuemanda sündroom : rahvusvaheline

  18. Initial-value problem for the Gardner equation applied to nonlinear internal waves

    Science.gov (United States)

    Rouvinskaya, Ekaterina; Kurkina, Oxana; Kurkin, Andrey; Talipova, Tatiana; Pelinovsky, Efim

    2017-04-01

    solitons (family with positive polarity, and family with negative polarity bounded below by the amplitude of 2) and two-parametric family of breathers (oscillatory wave packets). In this case varying amplitude and width of bell-shaped initial impulse leads to plenty of different evolutionary scenarios with the generation of solitary waves, breathers, solibores and nonlinear Airy wave in their various combinations. Statistical analysis of the wave field in time shows almost permanent substantial exceedance of the level of the significant wave height in some position in spatial coordinate. Evolution of Fourier spectrum of the wave field is also analyzed, and its behavior after a long time of initial wave evolution demonstrates the power asymptotic for small wave numbers and exponential asymptotic for large wave numbers. The presented results of research are obtained with the support of the grant of the President of the Russian Federation for state support of the young Russian scientists - Candidates of Sciences (MK-5208.2016.5) and Russian Foundation for Basic Research grant 16-05-00049. References: Grimshaw R., Pelinovsky D., Pelinovsky E and Slunyaev A. Generation of large-amplitude solitons in the extended Korteweg-de Vries equation // Chaos, 2002. - V.12. - No 4. - 1070-1076. Grimshaw, R., Slunyaev, A., and Pelinovsky, E. Generation of solitons and breathers in the extended Korteweg-de Vries equation with positive cubic nonlinearity //Chaos, 2010. - vol. 20.-013102. Kurkina O.E., Kurkin A.A., Soomere T., Pelinovsky E.N., Rouvinskaya E.A. Higher-order (2+4) Korteweg-de Vries - like equation for interfacial waves in a symmetric three-layer fluid // Physics of Fluids, 2011. - Volume 23. - Issue 11. - p.116602--1--13. Kurkina O., Rouvinskaya E., Talipova T., Kurkin A., Pelinovsky E. Nonlinear disintegration of sine wave in the framework of the Gardner equation // Physica D: Nonlinear Phenomena, 2015. - doi:10.1016/j.physd.2015.12.007. Pelinovsky E., Polukhina O., Slunyaev A

  19. Detection of abnormalities in the superficial zone of cartilage repaired using a tissue engineered construct derived from synovial stem cells

    Directory of Open Access Journals (Sweden)

    W Ando

    2012-09-01

    Full Text Available The present study investigated the surface structure and mechanical properties of repair cartilage generated from a tissue engineered construct (TEC derived from synovial mesenchymal stem cells at six months post-implantation compared to those of uninjured cartilage. TEC-mediated repair tissue was cartilaginous with Safranin O staining, and had comparable macro-scale compressive properties with uninjured cartilage. However, morphological assessments revealed that the superficial zone of TEC-mediated tissue was more fibrocartilage-like, in contrast to the middle or deep zones that were more hyaline cartilage-like with Safranin O staining. Histological scoring of the TEC-mediated tissue was significantly lower in the superficial zone than in the middle and deep zones. Scanning electron microscopy showed a thick tangential bundle of collagen fibres at the most superficial layer of uninjured cartilage, while no corresponding structure was detected at the surface of TEC-mediated tissue. Immunohistochemical analysis revealed that PRG4 was localised in the superficial area of uninjured cartilage, as well as the TEC-mediated tissue. Friction testing showed that the lubrication properties of the two tissues was similar, however, micro-indentation analysis revealed that the surface stiffness of the TEC-repair tissue was significantly lower than that of uninjured cartilage. Permeability testing indicated that the TEC-mediated tissue exhibited lower water retaining capacity than did uninjured cartilage, specifically at the superficial zone. Thus, TEC-mediated tissue exhibited compromised mechanical properties at the superficial zone, properties which need improvement in the future for maintenance of long term repair cartilage integrity.

  20. Detection of abnormalities in the superficial zone of cartilage repaired using a tissue engineered construct derived from synovial stem cells.

    Science.gov (United States)

    Ando, Wataru; Fujie, Hiromichi; Moriguchi, Yu; Nansai, Ryosuke; Shimomura, Kazunori; Hart, David A; Yoshikawa, Hideki; Nakamura, Norimasa

    2012-09-28

    The present study investigated the surface structure and mechanical properties of repair cartilage generated from a tissue engineered construct (TEC) derived from synovial mesenchymal stem cells at six months post-implantation compared to those of uninjured cartilage. TEC-mediated repair tissue was cartilaginous with Safranin O staining, and had comparable macro-scale compressive properties with uninjured cartilage. However, morphological assessments revealed that the superficial zone of TEC-mediated tissue was more fibrocartilage-like, in contrast to the middle or deep zones that were more hyaline cartilage-like with Safranin O staining. Histological scoring of the TEC-mediated tissue was significantly lower in the superficial zone than in the middle and deep zones. Scanning electron microscopy showed a thick tangential bundle of collagen fibres at the most superficial layer of uninjured cartilage, while no corresponding structure was detected at the surface of TEC-mediated tissue. Immunohistochemical analysis revealed that PRG4 was localised in the superficial area of uninjured cartilage, as well as the TEC-mediated tissue. Friction testing showed that the lubrication properties of the two tissues was similar, however, micro-indentation analysis revealed that the surface stiffness of the TEC-repair tissue was significantly lower than that of uninjured cartilage. Permeability testing indicated that the TEC-mediated tissue exhibited lower water retaining capacity than did uninjured cartilage, specifically at the superficial zone. Thus, TEC-mediated tissue exhibited compromised mechanical properties at the superficial zone, properties which need improvement in the future for maintenance of long term repair cartilage integrity.

  1. Morphine hyposensitivity in streptozotocin-diabetic rats: Reversal by dietary l-arginine treatment.

    Science.gov (United States)

    Lotfipour, Shahrdad; Smith, Maree T

    2018-01-01

    Painful diabetic neuropathy (PDN) is a long-term complication of diabetes. Defining symptoms include mechanical allodynia (pain due to light pressure or touch) and morphine hyposensitivity. In our previous work using the streptozotocin (STZ)-diabetic rat model of PDN, morphine hyposensitivity developed in a temporal manner with efficacy abolished at 3 months post-STZ and maintained for 6 months post-STZ. As this time course mimicked that for the temporal development of hyposensitivity to the pain-relieving effects of the furoxan nitric oxide (NO) donor, PRG150 (3-methylfuroxan-4-carbaldehyde) in STZ-diabetic rats, we hypothesized that progressive depletion of endogenous NO bioactivity may underpin the temporal loss of morphine sensitivity in STZ-diabetic rats. Furthermore, we hypothesized that replenishment of NO bioactivity may restore morphine sensitivity in these animals. Diabetes was induced in male Dark Agouti rats by intravenous injection of STZ (85 mg/kg). Diabetes was confirmed on day 7 if blood glucose concentrations were ≥15 mmol/L. Mechanical allodynia was fully developed in the bilateral hindpaws by 3 weeks of STZ-diabetes in rats and this was maintained for the study duration. Morphine hyposensitivity developed in a temporal manner with efficacy abolished by 3 months post-STZ. Administration of dietary l-arginine (NO precursor) at 1 g/d to STZ-diabetic rats according to a 15-week prevention protocol initiated at 9 weeks post-STZ prevented abolition of morphine efficacy. When given as an 8-week intervention protocol in rats where morphine efficacy was abolished, dietary l-arginine at 1 g/d progressively rescued morphine efficacy and potency. Our findings implicate NO depletion in the development of morphine hyposensitivity in STZ-diabetic rats. © 2017 John Wiley & Sons Australia, Ltd.

  2. Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (II) Physiological and Symptomatic Responses of Early-Postmenopausal Women to Standardized doses of Maca in Double Blind, Randomized, Placebo-Controlled, Multi-Centre Clinical Study.

    Science.gov (United States)

    Meissner, H O; Mscisz, A; Reich-Bilinska, H; Kapczynski, W; Mrozikiewicz, P; Bobkiewicz-Kozlowska, T; Kedzia, B; Lowicka, A; Barchia, I

    2006-12-01

    This was a double-blind, randomized, placebo-corrected, outpatient, multi-centre (five sites) clinical study, in which a total of 168 Caucasian early-postmenopausal women volunteers (age>49 years) participated after fulfilling the criteria: follicle stimulating hormone (FSH) >30 IU/ml and estrogen (E2) Maca (Maca-GO) treatment, according to different monthly treatment sequences scheduled for each site. Two 500 mg vegetable hard gel capsules with Maca-GO or Placebo powder were self-administered twice daily with meals (total 2 g/day) during three (Trial I; n=102) or four (Trial II; n=66) months study periods. At the baseline and follow- up monthly intervals, blood levels of FSH, E2, progesterone (PRG) and lutinizing hormone (LH), as well as serum cholesterol (CHOL), triglycerides (TRG), high- and low density lipoproteins (HDL and LDL) were measured. Menopausal symptoms were assessed according to Greene's Score (GMS) and Kupperman's Index (KMI). Data were analyzed using multivariate technique on blocs of monthly results in one model and Maca versus Placebo contrast in another model. A total of 124 women concluded the study. Maca-GO significantly stimulated production of E2 (PMaca-GO significantly reduced both frequency and severity of individual menopausal symptoms (hot flushes and night sweating in particular) resulting in significant (P<0.001) alleviation of KMI (from 22 to 10), thus, offering an attractive non-hormonal addition to the choices available to early-postmenopausal women in the form of a natural plant alternative to Hormone Replacement Therapy (HRT) - hence, reducing dependence on hormone therapy programs.

  3. Talking about social conflict in the MRI scanner: neural correlates of being empathized with.

    Science.gov (United States)

    Seehausen, Maria; Kazzer, Philipp; Bajbouj, Malek; Heekeren, Hauke R; Jacobs, Arthur M; Klann-Delius, Gisela; Menninghaus, Winfried; Prehn, Kristin

    2014-01-01

    This study investigated the emotional effects and neural correlates of being empathized with while speaking about a currently experienced real-life social conflict during fMRI. Specifically, we focused on the effects of cognitive empathy in the form of paraphrasing, a technique regularly used in conflict resolution. 22 participants underwent fMRI while being interviewed on their social conflict and receiving empathic or unempathic responses from the interviewer. Skin conductance response (SCR) and self-report ratings of feeling understood and emotional valence were used to assess emotional responses. Results confirm previous findings indicating that cognitive empathy exerts a positive short-term effect on emotions in social conflict, while at the same time increasing autonomic arousal reflected by SCR. Effects of paraphrasing and unempathic interventions as indicated by self-report ratings varied depending on self-esteem, pre-interview negative affect, and participants' empathy quotient. Empathic responses engaged a fronto-parietal network with activity in the right precentral gyrus (PrG), left middle frontal gyrus (MFG), left inferior parietal gyrus (IPG), and right postcentral gyrus (PoG). Processing unempathic responses involved a fronto-temporal network with clusters peaking in the left inferior frontal gyrus, pars triangularis (IFGTr), and right temporal pole (TP). A specific modeling of feeling misunderstood activated a network consisting of the IFG, left TP, left Heschl gyrus, IFGTr, and right precuneus, extending to several limbic regions, such as the insula, amygdala, putamen, and anterior cingulate cortex/right middle cingulum (ACC/MCC). The results support the effectiveness of a widely used conflict resolution technique, which may also be useful for professionals who regularly deal with and have to de-escalate situations highly charged with negative emotion, e.g. physicians or judges. © 2013 Elsevier Inc. All rights reserved.

  4. Age-Specific Normal Reference Range for Serum Anti-Müllerian Hormone in Healthy Chinese Han Women: A nationwide Population-Based Study.

    Science.gov (United States)

    Du, Xiaofang; Ding, Ting; Zhang, Hanwang; Zhang, Cuilian; Ma, Wenmin; Zhong, Ying; Qu, Wenyu; Zheng, Jie; Liu, Yi; Li, Zhiying; Huang, Kecheng; Deng, Song; Ma, Lanfang; Yang, Jun; Jiang, Jingjing; Yang, Shuhong; Huang, Jia; Wu, Meng; Fang, Li; Lu, Yunping; Luo, Aiyue; Wang, Shixuan

    2016-08-01

    The increasing use of anti-Müllerian hormone (AMH) in clinic has raised concerns regarding the reliable reference range for this test. However, the reference range for AMH in normal Chinese female population has not been established. Furthermore, relationship between AMH and other clinical markers such as body mass index (BMI) and antral follicle counts (AFCs) and other sex-related hormones have not been examined in normal population-based women. We aimed to determine the age-specific reference range for serum AMH in healthy Chinese women throughout reproductive age to menopause and to estimate relationship between AMH and other clinical markers in healthy women. In this multicenter and nationwide study, advertisements were used to recruit 2055 women, aged 20 to 55 years, from 6 different regions in China; 1590 (77.37%) women met the inclusion criteria for the reference range population. We measured the baseline serum AMH levels using new Beckman Coulter Gen II assay. Serum concentration of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), prolactin (PRL), progesterone (PRG), and AFCs were also determined in the follicular phase. The AMH-Age nomogram and AMH levels of different age-groups and the relationship between AMH and other clinical markers. Serum AMH concentrations declined progressively with age. A quadratic model defined as log (AMH) = (-1.970 + 0.296 × Age - 0.006 × Age(2)) fitted best the decline of AMH with age. The median AMH levels were 6.23, 5.65, 4.55, 3.74, 2.78, and 1.09 ng/mL for the 20 ≤ age women. © The Author(s) 2016.

  5. Influence of extremely low frequency, low energy electromagnetic fields and combined mechanical stimulation on chondrocytes in 3-D constructs for cartilage tissue engineering.

    Science.gov (United States)

    Hilz, Florian M; Ahrens, Philipp; Grad, Sibylle; Stoddart, Martin J; Dahmani, Chiheb; Wilken, Frauke L; Sauerschnig, Martin; Niemeyer, Philipp; Zwingmann, Jörn; Burgkart, Rainer; von Eisenhart-Rothe, Rüdiger; Südkamp, Norbert P; Weyh, Thomas; Imhoff, Andreas B; Alini, Mauro; Salzmann, Gian M

    2014-02-01

    Articular cartilage, once damaged, has very low regenerative potential. Various experimental approaches have been conducted to enhance chondrogenesis and cartilage maturation. Among those, non-invasive electromagnetic fields have shown their beneficial influence for cartilage regeneration and are widely used for the treatment of non-unions, fractures, avascular necrosis and osteoarthritis. One very well accepted way to promote cartilage maturation is physical stimulation through bioreactors. The aim of this study was the investigation of combined mechanical and electromagnetic stress affecting cartilage cells in vitro. Primary articular chondrocytes from bovine fetlock joints were seeded into three-dimensional (3-D) polyurethane scaffolds and distributed into seven stimulated experimental groups. They either underwent mechanical or electromagnetic stimulation (sinusoidal electromagnetic field of 1 mT, 2 mT, or 3 mT; 60 Hz) or both within a joint-specific bioreactor and a coil system. The scaffold-cell constructs were analyzed for glycosaminoglycan (GAG) and DNA content, histology, and gene expression of collagen-1, collagen-2, aggrecan, cartilage oligomeric matrix protein (COMP), Sox9, proteoglycan-4 (PRG-4), and matrix metalloproteinases (MMP-3 and -13). There were statistically significant differences in GAG/DNA content between the stimulated versus the control group with highest levels in the combined stimulation group. Gene expression was significantly higher for combined stimulation groups versus static control for collagen 2/collagen 1 ratio and lower for MMP-13. Amongst other genes, a more chondrogenic phenotype was noticed in expression patterns for the stimulated groups. To conclude, there is an effect of electromagnetic and mechanical stimulation on chondrocytes seeded in a 3-D scaffold, resulting in improved extracellular matrix production. © 2013 Wiley Periodicals, Inc.

  6. Building 235-F Goldsim Fate And Transport Model

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, G. A.; Phifer, M. A.

    2012-09-14

    Savannah River National Laboratory (SRNL) personnel, at the request of Area Completion Projects (ACP), evaluated In-Situ Disposal (ISD) alternatives that are under consideration for deactivation and decommissioning (D&D) of Building 235-F and the Building 294-2F Sand Filter. SRNL personnel developed and used a GoldSim fate and transport model, which is consistent with Musall 2012, to evaluate relative to groundwater protection, ISD alternatives that involve either source removal and/or the grouting of portions or all of 235-F. This evaluation was conducted through the development and use of a Building 235-F GoldSim fate and transport model. The model simulates contaminant release from four 235-F process areas and the 294-2F Sand Filter. In addition, it simulates the fate and transport through the vadose zone, the Upper Three Runs (UTR) aquifer, and the Upper Three Runs (UTR) creek. The model is designed as a stochastic model, and as such it can provide both deterministic and stochastic (probabilistic) results. The results show that the median radium activity concentrations exceed the 5 ?Ci/L radium MCL at the edge of the building for all ISD alternatives after 10,000 years, except those with a sufficient amount of inventory removed. A very interesting result was that grouting was shown to basically have minimal effect on the radium activity concentration. During the first 1,000 years grouting may have some small positive benefit relative to radium, however after that it may have a slightly deleterious effect. The Pb-210 results, relative to its 0.06 ?Ci/L PRG, are essentially identical to the radium results, but the Pb-210 results exhibit a lesser degree of exceedance. In summary, some level of inventory removal will be required to ensure that groundwater standards are met.

  7. Mice Lacking the β2 Adrenergic Receptor Have a Unique Genetic Profile before and after Focal Brain Ischaemia

    Directory of Open Access Journals (Sweden)

    Robin E White

    2012-08-01

    Full Text Available The role of the β2AR (β2 adrenergic receptor after stroke is unclear as pharmacological manipulations of the β2AR have produced contradictory results. We previously showed that mice deficient in the β2AR (β2KO had smaller infarcts compared with WT (wild-type mice (FVB after MCAO (middle cerebral artery occlusion, a model of stroke. To elucidate mechanisms of this neuroprotection, we evaluated changes in gene expression using microarrays comparing differences before and after MCAO, and differences between genotypes. Genes associated with inflammation and cell deaths were enriched after MCAO in both genotypes, and we identified several genes not previously shown to increase following ischaemia (Ccl9, Gem and Prg4. In addition to networks that were similar between genotypes, one network with a central core of GPCR (G-protein-coupled receptor and including biological functions such as carbohydrate metabolism, small molecule biochemistry and inflammation was identified in FVB mice but not in β2KO mice. Analysis of differences between genotypes revealed 11 genes differentially expressed by genotype both before and after ischaemia. We demonstrate greater Glo1 protein levels and lower Pmaip/Noxa mRNA levels in β2KO mice in both sham and MCAO conditions. As both genes are implicated in NF-κB (nuclear factor κB signalling, we measured p65 activity and TNFα (tumour necrosis factor α levels 24 h after MCAO. MCAO-induced p65 activation and post-ischaemic TNFα production were both greater in FVB compared with β2KO mice. These results suggest that loss of β2AR signaling results in a neuroprotective phenotype in part due to decreased NF-κB signalling, decreased inflammation and decreased apoptotic signalling in the brain.

  8. Optimization of Methods for Articular Cartilage Surface Tissue Engineering: Cell Density and Transforming Growth Factor Beta Are Critical for Self-Assembly and Lubricin Secretion.

    Science.gov (United States)

    Iwasa, Kenjiro; Reddi, A Hari

    2017-07-01

    Lubricin/superficial zone protein (SZP)/proteoglycan4 (PRG4) plays an important role in boundary lubrication in articular cartilage. Lubricin is secreted by superficial zone chondrocytes and synoviocytes of the synovium. The specific objective of this investigation is to optimize the methods for tissue engineering of articular cartilage surface. The aim of this study is to investigate the effect of cell density on the self-assembly of superficial zone chondrocytes and lubricin secretion as a functional assessment. Superficial zone chondrocytes were cultivated as a monolayer at low, medium, and high densities. Chondrocytes at the three different densities were treated with transforming growth factor beta (TGF-β)1 twice a week or daily, and the accumulated lubricin in the culture medium was analyzed by immunoblots and quantitated by enzyme-linked immunosorbent assay (ELISA). Cell numbers in low and medium densities were increased by TGF-β1; whereas cell numbers in high-density cell cultures were decreased by twice-a-week treatment of TGF-β1. On the other hand, the cell numbers were maintained by daily TGF-β treatment. Immunoblots and quantitation of lubricin by ELISA analysis indicated that TGF-β1 stimulated lubricin secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-β treatment. It is noteworthy that the daily treatment of TGF-β1 increased lubricin much higher compared with twice-a-week treatment. These data demonstrate that daily treatment is optimal for the TGF-β1 response in a higher density of monolayer cultures. These findings have implications for self-assembly of surface zone chondrocytes of articular cartilage for application in tissue engineering of articular cartilage surface.

  9. Reconsidering the Grenada revolution

    Directory of Open Access Journals (Sweden)

    Jay R. Mandle

    1995-01-01

    Full Text Available [First paragraph] Caribbean Revolutions and Revolutionary Theory: An Assessment of Cuba, Nicaragua and Grenada. BRIAN MEEKS. London: Macmillan Caribbean, 1993. ix + 210 pp. (Paper n.p. The Grenada Invasion: Politics, Law, and Foreign Policy Decisionmaking. ROBERT J. BECK. Boulder: Westview, 1993. xiv + 263 pp. (Cloth US$ 49.95 The Gorrión Tree: Cuba and the Grenada Revolution. JOHN WALTON COTMAN. New York: Peter Lang, 1993. xvi + 272 pp. (Cloth US$ 48.95 These three books might be thought of as a second generation of studies concerned with the rise, rule, and destruction of the People's Revolutionary Government (PRG in Grenada. The circumstances surrounding the accession to power in 1979 of the government led by Maurice Bishop, the nature of its rule, and its violent demise in 1983 resulted in the appearance during the mid-1980s of an extensive literature on the Grenada Revolution. Some of these works were scholarly, others polemical. But what they all had in common was the desire to examine, either critically or otherwise, something which was unique in the historical experience of the English-speaking Caribbean. Never, before the rule of the New JEWEL Movement (NJM in Grenada, had a Leninist party come to power; never had a violent coup initiated a new political regime; never had a Caribbean government so explicitly rejected U.S. hegemony in the area; and never, before October 1983, had a government experienced quite so dramatic a crisis as that in Grenada, one which resulted in the killing of the Prime Minister and numerous others of his supporters.

  10. CT-guided percutaneous gastrostomy: success rate, early and late complications; CT-gesteuerte perkutane Gastrostomie: Technischer Erfolg, Frueh- und Spaetkomplikationen

    Energy Technology Data Exchange (ETDEWEB)

    Gottschalk, A.; Voelk, M. [Radiologie, Bundeswehrkrankenhaus Ulm (Germany); Strotzer, M. [Radiologie, Klinikum Hohe Warte (Germany); Feuerbach, S.; Rogler, G. [Radiologie, Klinikum der Universitaet Regensburg (Germany); Seitz, J. [Radiologie, MVZ Dr. Neumaier und Kollegen (Germany)

    2007-04-15

    Purpose: Percutaneous endoscopic gastrostomy (PEG) and percutaneous radiologic gastrostomy (PRG) are the standard methods of ensuring long-term enteral food intake in patients with dysphagia caused by neoplasia or neurological disorders. High-grade obstructions of the upper digestive tract or inadequate transillumination can prevent PEG. CT-guided percutaneous gastrostomy (PG) represents a special technique for enabling gastrostomy in patients for whom the endoscopic method is impossible. The aim of this study was to evaluate the results and complications of CT-guided percutaneous gastrostomy. Materials and Methods: CT-guided PG was performed in 83 patients, mostly with malignancy of the upper respiratory or digestive tract. Medical records for these patients were reviewed, and the results and complications of the CT-guided PG were analyzed retrospectively. Complications were grouped into four categories: Major and minor complications as well as early and late complications. Results: In 95.2 % of all cases (79/83), CT-guided PG was successful in the first attempt. Within the first 3 days, 5 major complications including 4 tube dislocations and one case of peritonitis were found in 4/79 patients (5.1 %). One of these patients experienced two early major complications. Early minor complications, mainly local skin irritations and temporary stomachache, were observed in 31 patients (39.2 %). Three days after CT-guided PG, 4 cases of major complications were documented, yielding a total rate of major complications was 8.7 % (7/79). Hemorrhage requiring blood transfusion or perforation after gastrostomy was not observed. 29.1 % of the patients (23/79) experienced late minor complications. (orig.)

  11. Building 235-F Goldsim Fate And Transport Model

    International Nuclear Information System (INIS)

    Taylor, G. A.; Phifer, M. A.

    2012-01-01

    Savannah River National Laboratory (SRNL) personnel, at the request of Area Completion Projects (ACP), evaluated In-Situ Disposal (ISD) alternatives that are under consideration for deactivation and decommissioning (D and D) of Building 235-F and the Building 294-2F Sand Filter. SRNL personnel developed and used a GoldSim fate and transport model, which is consistent with Musall 2012, to evaluate relative to groundwater protection, ISD alternatives that involve either source removal and/or the grouting of portions or all of 235-F. This evaluation was conducted through the development and use of a Building 235-F GoldSim fate and transport model. The model simulates contaminant release from four 235-F process areas and the 294-2F Sand Filter. In addition, it simulates the fate and transport through the vadose zone, the Upper Three Runs (UTR) aquifer, and the Upper Three Runs (UTR) creek. The model is designed as a stochastic model, and as such it can provide both deterministic and stochastic (probabilistic) results. The results show that the median radium activity concentrations exceed the 5 ρCi/L radium MCL at the edge of the building for all ISD alternatives after 10,000 years, except those with a sufficient amount of inventory removed. A very interesting result was that grouting was shown to basically have minimal effect on the radium activity concentration. During the first 1,000 years grouting may have some small positive benefit relative to radium, however after that it may have a slightly deleterious effect. The Pb-210 results, relative to its 0.06 ρCi/L PRG, are essentially identical to the radium results, but the Pb-210 results exhibit a lesser degree of exceedance. In summary, some level of inventory removal will be required to ensure that groundwater standards are met

  12. Quantification of the adrenal cortex hormones with radioimmunoassay

    Energy Technology Data Exchange (ETDEWEB)

    Badillo A, V.; Carrera D, A. A.; Ibarra M, C. M., E-mail: vbadillocren@hotmail.co [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Calle Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2010-10-15

    The pathologies of the adrenal cortex -adrenal insufficiency and Cushing syndrome- have their origin on the deficit or hypersecretion of some of the hormones that are secreted by the adrenal cortex, which is divided in three zones anatomically defined: the external zone, also called the zona glomerulosa, which is the main production site of aldosterone and mineralocorticoids; the internal zone, or zona reticularis, that produces androgens; and the external zone, or zone 1 orticotrop, which is responsible for producing glucocorticoids. In this work, a quantitative analysis of those hormones and their pathologic trigger was made; the quantification was made in the laboratory by means of highly sensitive and specific techniques, in this case, the radioimmunoassay, in which a radioisotope I-125 is used. This technique is based on the biochemical bond-type reaction, because it requires of a substance called the linker, which bonds to another called ligand. This reaction is also known as antigen-antibody (Ag-Ab), where the results of the reaction will depend on the quantity of antigen in the sample and on its affinity for the antibody. In this work, a 56 patients (of which 13 were men and 43 women) study was made. The cortisol, the ACTH, the androsterone and the DHEA values were very elevated in the majority of the cases corresponding to women, predominating cortisol; while in men, a notorious elevation of the 17 {alpha}-OH-PRG and of the DHEA-SO{sub 4} was observed. Based on that, we can conclude that 51 of them did not have mayor complications, because they just went to the laboratory once, while the remaining 5 had a medical monitoring, and they visited the laboratory more than one occasion, tell about a difficulty on their improvement. According to the results, an approximate relation of 8:2 women:men, respectively, becomes clear to the hormonal pathologies of the adrenal cortex. (Author)

  13. Radiation therapy for malignant tumors in patients 80 years of age or older

    International Nuclear Information System (INIS)

    Mitsuhashi, Norio; Niibe, Hideo; Hayakawa, Kazushige; Takahashi, Mitsuhiro; Nozaki, Miwako; Yamakawa, Michitaka

    1992-01-01

    We report here, results of investigation of changes in the condition of elderly patients, 80 years of age or older (EP-80), treated with radiation, and analysis of the results of radiotherapy to assess the value of radiotherapy in treating the elderly. Between 1970 and 1989, 294 EP-80 with various malignant tumors received radiation therapy at the Department of Radiology, Gunma University Hospital. The number of EP-80 treated has increased recently to about thirty per year, and their incidence among newly registered patients has also increased to over 5%. The 5-year cause specific survival rates for male and female were 14% and 32%, respectively. There was a significant difference between the survival rates for male and female (x 2 =11.89, p=0.00056) because of inclusion of a significant proportion of female patients with gynecological malignancies. The 5-year survival rate for patients in the curative radiotherapy group (CRG) was 30%, whereas no patient of the palliative radiotherapy group (PRG) has survived for 5 years (x 2 =90.23, p=0.00000). In the CRG, the survival rate for females was significantly higher than that for males (x 2 =11.48, p=0.00070). Thirty-one patients survived for 5 year. Head and neck cancer and uterine lervix cancer were the most common tumors in 5 year survivors. Age was not a significant prognostic factor in the elderly patients treated with radiation. It is considered that radiation therapy is as valuable in elderly patients as in the younger patient population. (author)

  14. Quantification of the adrenal cortex hormones with radioimmunoassay

    International Nuclear Information System (INIS)

    Badillo A, V.; Carrera D, A. A.; Ibarra M, C. M.

    2010-10-01

    The pathologies of the adrenal cortex -adrenal insufficiency and Cushing syndrome- have their origin on the deficit or hypersecretion of some of the hormones that are secreted by the adrenal cortex, which is divided in three zones anatomically defined: the external zone, also called the zona glomerulosa, which is the main production site of aldosterone and mineralocorticoids; the internal zone, or zona reticularis, that produces androgens; and the external zone, or zone 1 orticotrop, which is responsible for producing glucocorticoids. In this work, a quantitative analysis of those hormones and their pathologic trigger was made; the quantification was made in the laboratory by means of highly sensitive and specific techniques, in this case, the radioimmunoassay, in which a radioisotope I-125 is used. This technique is based on the biochemical bond-type reaction, because it requires of a substance called the linker, which bonds to another called ligand. This reaction is also known as antigen-antibody (Ag-Ab), where the results of the reaction will depend on the quantity of antigen in the sample and on its affinity for the antibody. In this work, a 56 patients (of which 13 were men and 43 women) study was made. The cortisol, the ACTH, the androsterone and the DHEA values were very elevated in the majority of the cases corresponding to women, predominating cortisol; while in men, a notorious elevation of the 17 α-OH-PRG and of the DHEA-SO 4 was observed. Based on that, we can conclude that 51 of them did not have mayor complications, because they just went to the laboratory once, while the remaining 5 had a medical monitoring, and they visited the laboratory more than one occasion, tell about a difficulty on their improvement. According to the results, an approximate relation of 8:2 women:men, respectively, becomes clear to the hormonal pathologies of the adrenal cortex. (Author)

  15. Speciation of arsenic, selenium, and chromium in wildfire impacted soils and ashes

    Science.gov (United States)

    Wolf, Ruth E.; Hoefen, Todd M.; Hageman, Philip L.; Morman, Suzette A.; Plumlee, Geoffrey S.

    2010-01-01

    In 2007-09, California experienced several large wildfires that damaged large areas of forest and destroyed many homes and buildings. The U.S. Geological Survey collected samples from the Harris, Witch, Grass Valley, Ammo, Santiago, Canyon, Jesusita, and Station fires for testing to identify any possible characteristics of the ashes and soils from burned areas that may be of concern for their impact on water quality, human health, and endangered species. The samples were subjected to analysis for bulk chemical composition for 44 elements by inductively coupled plasma mass spectrometry (ICP-MS) after acid digestion and de-ionized water leach tests for pH, alkalinity, conductivity, and anions. Water leach tests generated solutions ranging from pH 10-12, suggesting that ashes can generate caustic alkalinity in contact with rainwater or body fluids (for example, sweat and fluids in the respiratory tract). Samples from burned residential areas in the 2007 fires had elevated levels for several metals, including: As, Pb, Sb, Cu, Zn, and Cr. In some cases, the levels found were above the U.S. Environmental Protection Agency (USEPA) preliminary remediation goals (PRG) for soils. Speciation analyses were conducted on de-ionized water and simulated lung fluid leachates for As(III), As(V), Se(IV), Se(VI), Cr(III), and Cr(VI). All species were determined in the same analytical run using an ion-pairing HPLC-ICP-MS method. For leachates containing high levels of total Cr, the majority of the chromium was present in the hexavalent, Cr(VI), form. Higher total and hexavalent chromium levels were observed for samples collected from burned residential areas. Arsenic was also generally present in the more oxidized, As(V), form. Selenium (IV) and (VI) were present, but typically at levels below 2 ppb for most samples. Stability studies of leachate solutions under different storage conditions were performed and the suitability of different sample preservation methods for speciation

  16. Subsurface geology of the Lusi region: preliminary results from a comprehensive seismic-stratigraphic study.

    Science.gov (United States)

    Moscariello, Andrea; Do Couto, Damien; Lupi, Matteo; Mazzini, Adriano

    2016-04-01

    We investigate the subsurface data of a large sector in the Sidoarjo district (East Java, Indonesia) where the sudden catastrophic Lusi eruption started the 26th May 2006. Our goal is to understand the stratigraphic and structural features which can be genetically related to the surface manifestations of deep hydrothermal fluids and thus allow us to predict possible future similar phenomena in the region. In the framework of the Lusi Lab project (ERC grant n° 308126) we examined a series of densely spaced 2D reflection commercial seismic lines This allowed the reconstruction of the lateral variability of key stratigraphic horizons as well as the main tectonic features. In particular, we shed light on the deep structure of the Watukosek fault system and the associated fracture corridors crossing the entire stratigraphic successions. To the South-West, when approaching the volcanic complex, we could identify a clear contrast in seismic facies between chaotic volcanoclastic wedges and clastic-prone sedimentary successions as well as between the deeper stratigraphic units consisting of carbonates and lateral shales units. The latter show possible ductile deformation associated to fault-controlled diapirism which control in turns deformation of overlying stratigraphic units and deep geo-fluids circulation. Large collapse structures recognized in the study area (e.g. well PRG-1) are interpreted as the results of shale movement at depth. Similarly to Lusi, vertical deformation zones ("pipes"), likely associated with deeply rooted strike-slip systems seem to be often located at the interface between harder carbonate rocks forming isolated build ups and the laterally nearby clastic (shale-prone)-units. The mechanisms of deformation of structural features (strike vs dip slip systems) which may affect either the basement rock or the overlying deeper stratigraphic rocks is also being investigated to understand the relationship between deep and shallower (i.e. meteoric) fluid

  17. OECD MCCI project long-term 2-D molten core concrete interaction test design report, Rev. 0. September 30, 2002

    International Nuclear Information System (INIS)

    Farmer, M.T.; Kilsdonk, D.J.; Lomperski, S.; Aeschliman, R.W.; Basu, S.

    2011-01-01

    experiments to address remaining uncertainties related to long-term two-dimensional molten core-concrete interaction. In particular, for both wet and dry cavity conditions, there is uncertainty insofar as evaluating the lateral vs. axial power split during a core-concrete interaction due to a lack of experiment data. As a result, there are differences in the 2-D cavity erosion predicted by codes such as MELCOR, WECHSL, and COSACO. The first step towards generating this data is to produce a test plan for review by the Project Review Group (PRG). The purpose of this document is to provide this plan.

  18. Climate, environment and society in southern Italy during the last 2000 years. A review of the environmental, historical and archaeological evidence

    Science.gov (United States)

    Sadori, Laura; Giraudi, Carlo; Masi, Alessia; Magny, Michel; Ortu, Elena; Zanchetta, Giovanni; Izdebski, Adam

    2016-03-01

    This paper examines the interrelationship between the natural and human history of Sicily over the last 2000 years. It presents a close comparison of the data from the key multi-proxy site of Lago di Pergusa - located inland in the eastern part of Sicily - with the existing archaeological and textual evidence on the socio-economic processes. The article also includes a review of the available natural proxy archives from the Central Mediterranean. On the basis of the isotope and pollen data from the Lago di Pergusa core PRG2, we identified two humid periods (ca. 450-750 AD and ca. 1400-1800 AD) as well as a dry one (ca. 1100-1350 AD); our evidence corresponds closely with other environmental palaeoclimate proxies from the Mediterranean region. In our synthesis of the environmental, historical and archaeological evidence from southern Italy, we argue that during both periods of increased humidity - that is during the late antique-Byzantine times and during the late medieval and early modern periods - intense agricultural use of the Sicilian landscape developed on an unprecedented scale. This in turn contributed to the impressive demographic and economic expansion visible during these periods. A sudden period of aridity followed the first of these eras of humidity-related agricultural growth. This climatic shift, dated to around 750 AD, corresponds to a decrease in synanthropic taxa and a recovery of arboreal vegetation. We argue that in this case a climatic change contributed to socio-economic decline. Moreover, as this change occurred prior to the Arab invasion of Sicily in AD 827, the environmental processes may help to explain the collapse of Byzantine society on Sicily which, in turn made the Muslim conquest possible. After this event, there occurred a longer period of agricultural decline, lasting until around 1000 AD, after which we see the first signs of a slow recovery. Ongoing research in nearby archaeological sites will help defining if it was a local

  19. The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells.

    Science.gov (United States)

    Levato, Riccardo; Webb, William R; Otto, Iris A; Mensinga, Anneloes; Zhang, Yadan; van Rijen, Mattie; van Weeren, René; Khan, Ilyas M; Malda, Jos

    2017-10-01

    Cell-laden hydrogels are the primary building blocks for bioprinting, and, also termed bioinks, are the foundations for creating structures that can potentially recapitulate the architecture of articular cartilage. To be functional, hydrogel constructs need to unlock the regenerative capacity of encapsulated cells. The recent identification of multipotent articular cartilage-resident chondroprogenitor cells (ACPCs), which share important traits with adult stem cells, represents a new opportunity for cartilage regeneration. However, little is known about the suitability of ACPCs for tissue engineering, especially in combination with biomaterials. This study aimed to investigate the potential of ACPCs in hydrogels for cartilage regeneration and biofabrication, and to evaluate their ability for zone-specific matrix production. Gelatin methacryloyl (gelMA)-based hydrogels were used to culture ACPCs, bone marrow mesenchymal stromal cells (MSCs) and chondrocytes, and as bioinks for printing. Our data shows ACPCs outperformed chondrocytes in terms of neo-cartilage production and unlike MSCs, ACPCs had the lowest gene expression levels of hypertrophy marker collagen type X, and the highest expression of PRG4, a key factor in joint lubrication. Co-cultures of the cell types in multi-compartment hydrogels allowed generating constructs with a layered distribution of collagens and glycosaminoglycans. By combining ACPC- and MSC-laden bioinks, a bioprinted model of articular cartilage was generated, consisting of defined superficial and deep regions, each with distinct cellular and extracellular matrix composition. Taken together, these results provide important information for the use of ACPC-laden hydrogels in regenerative medicine, and pave the way to the biofabrication of 3D constructs with multiple cell types for cartilage regeneration or in vitro tissue models. Despite its limited ability to repair, articular cartilage harbors an endogenous population of progenitor cells

  20. Inventory of atmospheric pollutant and greenhouse gas emissions in France. Sectoral series and extended analyses - SECTEN Format, April 2011

    International Nuclear Information System (INIS)

    Chang, Jean-Pierre; Fontelle, Jean-Pierre; Serveau, Laetitia; Allemand, Nadine; Jeannot, Coralie; Andre, Jean-Marc; Joya, Romain; Deflorenne, Emmanuel; Martinet, Yann; Druart, Ariane; Mathias, Etienne; Gavel, Antoine; Nicco, Laetitia; Gueguen, Celine; Prouteau, Emilie; Jabot, Julien; Tuddenham, Mark; Jacquier, Guillaume; Vincent, Julien

    2011-04-01

    2009. Regarding the greenhouse gases, the trend is rather directed in a light increase (2, 2 % between 2009 and 2010 for the CO 2 and 1, 4 % in terms of PRG) because of the year 2009 is very marked by a context of economic crisis and a resumption begun in 2010. The preliminary estimations for year 2010 should therefore be considered with caution because they need to be consolidated. The results are presented at national level for each of the main sectors defined in the SECTEN format. A more detailed breakdown of each main sector is provided for the period 1990-2009. Results also focus on the different energy products and several analyses provide additional information on NMVOCs, PAHs HFCs, PFCs, global warming potential and particular sources, such as transport and off-road mobile sources (generators, machinery and vehicles used in construction, industry, agriculture and forestry, as well as household and gardening machinery). The report contains indications regarding the targets to which France has committed itself under international conventions and EU directives, in particular for climate change and for transboundary air pollution and air quality. These results show that on the whole emission trends observed are encouraging and especially reflect the reduction actions implemented. The table below summarises total emissions over the period 1990-2010 for all the above mentioned substances, as well as indicators concerning acidification and the greenhouse effect

  1. Archeologia e città: la ricostruzione della linea di costa

    Directory of Open Access Journals (Sweden)

    Daniela Giampaola

    2009-11-01

    Full Text Available Argomento del contributo è la storia del paesaggio costiero antistante il nucleo più antico della città di Napoli ricostruita attraverso la procedura dello scavo archeologico, nel corso dei lavori per la realizzazione della linea 1 e 6 della Metropolitana. L’intervento archeologico si è rivelato un’occasione irripetibile di conoscenza, per la sua ampia dimensione e per la circostanza che si è sviluppato in un comparto topografico unitario quale il water front cittadino. Esso appare straordinario per l’intreccio di fattori diversificati: per la sua complessità tecnica e metodologica, per la rilevanza delle acquisizioni scientifiche, per lo stretto rapporto con un’opera pubblica di carattere ingegneristico che è parte di una delle più importanti trasformazioni della città contemporanea, avviata attraverso il Piano comunale dei trasporti. Occorre innanzitutto sottolineare che le indagini, dal punto di vista metodologico-procedurale, documentano una precoce attività di archeologia preventiva, avviata sin dalla metà degli anni ‘90 del secolo scorso, in un momento lontano dalle leggi vigenti che regolamentano l’impatto archeologico rispetto alle opere pubbliche. Nello stesso momento dell’inserimento di norme specifiche di tutela archeologica nella variante del PRG della città di Napoli, in base ad una concertazione fra il Ministero per i Beni e le Attività Culturali, il Comune di Napoli e la Società Metropolitana, Concessionaria delle opere, si sono inserite le attività di natura archeologica , dalle prospezioni preliminari sino alle indagini estensive delle stazioni, all’interno del programma dell’opera pubblica di cui sono diventate una fase operativa preliminare e ineludibile. Il progetto della linea 1, il cui obiettivo è di collegare alla fascia collinare della città, di recente servita da un efficiente trasporto su ferro, il nucleo più antico dell’insediamento napoletano, risparmia l’area urbana di Neapolis

  2. Trasporti ed energia: strategie di pianificazione in ambito urbano

    Directory of Open Access Journals (Sweden)

    Ilaria Delponte

    2012-04-01

    Full Text Available The fight against climate changing pushed the States of the EuropeanUnion to adopt new, strong and efficient objectives to protect theenvironment and improve life condition in urban centers.Particular attention is paid to the reduction of CO2 emissions in orderto promote a more livable environment and sustainable urbandevelopment. This growing communitarian policy and vision representsa suitable context for the introduction of innovative urban planningand managing practices allowing an attentive exploitation of naturalresources.The principle of sustainable and durable development and the newconcept of “energy planning” take to a revision of existent tools(PRG-Piano Regolatore Generale, PUM-Piano Urbano della Mobilità,etc. used by Italian Public Administrations to plan and manage urbanspaces and to the introduction of new ones (PEC-Piano EnergeticoComunale, etc..From this modern point of view, the field of transport and mobilitycovers a strategic role for two main reasons. The first is the relevantcontribution of transports to the production of CO2 emissions(transports are responsible of the 30 - 40% of CO2 emissions in urbancenters and other toxic matters (PM10, NOx etc.; the second one isthe strong impact that the effectiveness of public transports can haveon citizens’ quality of life and the reduction of private cars’ use.Taking into account the wide range of fields, activities and serviceswhose efficiency and sustainability depends on that one of the urbanmobility system, a great number of actions can be proposed.The effective problem is the complexity of their mutual interaction inorder to satisfy urban exigencies and respect existing regulatoryindications.The analysis of alternative actions, technologies and scenarios thatLocal Administration can suppose to apply and/or realize might resultvery interesting taking into consideration also the recentcommunitarian policy of “20-20-20” aiming to reach a reduction of20% in greenhouse

  3. Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations.

    Science.gov (United States)

    Gormley, Matthew; Ona, Katherine; Kapidzic, Mirhan; Garrido-Gomez, Tamara; Zdravkovic, Tamara; Fisher, Susan J

    2017-08-01

    syncytiotrophoblast data highlighted the dysregulation of immune functions, morphogenesis, transport, and responses to vascular endothelial growth factor and progesterone. The invasive cytotrophoblast data provided evidence of alterations in cellular movement, which is consistent with the shallow invasion often associated with severe preeclampsia. Other dysregulated pathways included immune, lipid, oxygen, and transforming growth factor-beta responses. The data for endovascular cytotrophoblasts showed disordered metabolism, signaling, and vascular development. Additionally, the transcriptional data revealed the differential expression in severe preeclampsia of 2 classes of non-coding RNAs: long non-coding RNAs and small nucleolar RNAs. The long non-coding RNA, urothelial cancer associated 1, was the most highly up-regulated in this class. In situ hybridization confirmed severe preeclampsia-associated expression in syncytiotrophoblasts. The small nucleolar RNAs, which chemically modify RNA structure, also correlated with severe preeclampsia. Thus, we enumerated Cajal body foci, sites of small nucleolar RNA activity, in primary cytotrophoblasts that were isolated from control and severe preeclampsia placentas. In severe preeclampsia, cytotrophoblasts had approximately double the number of these foci as the control samples. A laser microdissection approach enabled the identification of novel messenger RNAs and non-coding RNAs that were misexpressed by various trophoblast subpopulations in severe preeclampsia. The results suggested new avenues of investigation, in particular, the roles of PRG2, Kell blood group determinants, and urothelial cancer associated 1 in syncytiotrophoblast diseases. Additionally, many of the newly identified dysregulated molecules might have clinical utility as biomarkers of severe preeclampsia. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  4. Local seismic network at the Olkiluoto site. Annual report for 2010

    International Nuclear Information System (INIS)

    Saari, J.; Malm, M.

    2011-11-01

    .8 to M L = 1.5 (M L = magnitude in local Richter's scale). Most of them are explosions. Three of the events are classified as induced microearthquakes. Three injection induced microearthquakes (M L = -1.6, M L = -2.1 and M L = -3.0) occurred on 16.12.2010. They can be associated with the structural orientation of the upper contact of the pegmatitic granite unit PRG44 or veined gneiss. The events locate about 50 - 80 meters above the closest excavated part of the ONKALO. Estimated peak slip values of the earthquakes are less than five μ m and the source radiuses less than five meters. According to seismic monitoring the rock mass surrounding the ONKALO has been stable in 2010. Indications of illegal or inappropriate works, which would have influence on the safety of the ONKALO, have not been found. (orig.)

  5. Local seismic network at the Olkiluoto site. Annual report for 2009

    International Nuclear Information System (INIS)

    Saari, J.; Malm, M.

    2010-06-01

    of the events are classified as excavation induced microearthquakes. Two excavation induced earthquakes (ML -0.2 and ML= -0.4) occurred on 14.10.2009. They can be associated with the lower contact of the pegmatitic granite unit PRG5 and veined gneiss as well as with brittle fault zone OL-BFZ176. The events locate about 100 - 150 meters from the closest excavated part of the ONKALO. Estimated peak slip values of the earthquakes are 37 μm and 19 μm and the source radiuses 12 and 13 meters. It was possible to calculate the fault plane solution only for the main shock, because the aftershock occurred only 30 ms after the main shock. However, it is rather likely that they have the same kind of mechanisms. The fault type is normal left-lateral oblique i.e. normal fault with a component of left-lateral strike. The main event represented mainly a pure slip along a fault plane, but it seems that a small implosion was also involved in it. In the main shock the hanging wall has moved to south, towards the excavated ONKALO and generated two microearthquakes. The direction of the slip vector correlates rather nicely with the location of the aftershock. According to seismic monitoring the rockmass surrounding the ONKALO has been stable in 2009. Indications of illegal or inappropriate works, which would have influence on the safety of the ONKALO, have not been found. (orig.)

  6. Inventory of atmospheric pollutant and greenhouse gas emissions in France. Sectoral series and extended analyses - SECTEN Format, April 2011; Inventaire des emissions de polluants atmospheriques et de gaz a effet de serre en France. Series sectorielles et analyses etendues - Format SECTEN, avril 2011

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Jean-Pierre; Fontelle, Jean-Pierre; Serveau, Laetitia; Allemand, Nadine; Jeannot, Coralie; Andre, Jean-Marc; Joya, Romain; Deflorenne, Emmanuel; Martinet, Yann; Druart, Ariane; Mathias, Etienne; Gavel, Antoine; Nicco, Laetitia; Gueguen, Celine; Prouteau, Emilie; Jabot, Julien; Tuddenham, Mark; Jacquier, Guillaume; Vincent, Julien

    2011-04-15

    rather favorable as far as the estimated level is below than observed in 2009. Regarding the greenhouse gases, the trend is rather directed in a light increase (2, 2 % between 2009 and 2010 for the CO{sub 2} and 1, 4 % in terms of PRG) because of the year 2009 is very marked by a context of economic crisis and a resumption begun in 2010. The preliminary estimations for year 2010 should therefore be considered with caution because they need to be consolidated. The results are presented at national level for each of the main sectors defined in the SECTEN format. A more detailed breakdown of each main sector is provided for the period 1990-2009. Results also focus on the different energy products and several analyses provide additional information on NMVOCs, PAHs HFCs, PFCs, global warming potential and particular sources, such as transport and off-road mobile sources (generators, machinery and vehicles used in construction, industry, agriculture and forestry, as well as household and gardening machinery). The report contains indications regarding the targets to which France has committed itself under international conventions and EU directives, in particular for climate change and for transboundary air pollution and air quality. These results show that on the whole emission trends observed are encouraging and especially reflect the reduction actions implemented. The table below summarises total emissions over the period 1990-2010 for all the above mentioned substances, as well as indicators concerning acidification and the greenhouse effect

  7. INDEPENDENT REVIEW OF THE X-701B GROUNDWATER REMEDY, PORTSMOUTH, OHIO: TECHNICAL EVALUATION AND RECOMMENDATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Eddy-Dilek, C.; Costanza, J.; Rossabi, J.; Early, T.; Skubal, K.; Magnuson, C.

    2008-12-15

    The Department of Energy Portsmouth Paducah Project Office requested assistance from Department of Energy Office of Environmental Management (EM-22) to provide independent technical experts to evaluate past and ongoing remedial activities at the Portsmouth facility that were completed to address TCE contamination associated with the X-701B groundwater plume and to make recommendations for future efforts. The Independent Technical Review team was provided with a detailed and specific charter. The charter requested that the technical team first review the past and current activities completed for the X-701B groundwater remedy for trichloroethene (TCE) in accordance with a Decision Document that was issued by Ohio EPA on December 8, 2003 and a Work Plan that was approved by Ohio EPA on September 22, 2006. The remedy for X-701B divides the activities into four phases: Phase I - Initial Source Area Treatment, Phase II - Expanded Source Area Treatment, Phase III - Evaluation and Reporting, and Phase IV - Downgradient Remediation and Confirmation of Source Area Treatment. Phase I of the remedy was completed during FY2006, and DOE has now completed six oxidant injection events within Phase II. The Independent Technical Review team was asked to evaluate Phase II activities, including soil and groundwater results, and to determine whether or not the criteria that were defined in the Work Plan for the Phase II end point had been met. The following criteria are defined in the Work Plan as an acceptable Phase II end point: (1) Groundwater samples from the identified source area monitoring wells have concentrations below the Preliminary Remediation Goal (PRG) for TCE in groundwater, or (2) The remedy is no longer effective in removing TCE mass from the source area. In addition, the charter specifies that if the Review Team determines that the Phase II endpoint has not been reached, then the team should address the following issues: (1) If additional injection events are

  8. EDITORIAL: Deep brain stimulation, deontology and duty: the moral obligation of non-abandonment at the neural interface Deep brain stimulation, deontology and duty: the moral obligation of non-abandonment at the neural interface

    Science.gov (United States)

    Fins, Joseph J.; MD; FACP

    2009-10-01

    conscious state, funded by Intelect Medical Inc. References [1] 1972 Editorial: Psychosurgery Lancet 7767 69-70 [2] Fins J J 2002 The ethical limits of neuroscience The Lancet Neurology 1 213 [3] Fins J J 2003 From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research Neurosurgery Clinics of North America 14 303-19 [4] Fins J J 2004 Deep brain stimulation Encyclopedia of Bioethics, Vol 2 3rd edn, ed S G Post (New York: MacMillan Reference) pp 629-34 [5] Fins J J 2004 Neuromodulation, free will and determinism: lessons from the psychosurgery debate Clinical Neuroscience Research 4 113-18 [6] Fins J J 2009 Deep brain stimulation: ethical issues in clinical practice and neurosurgical research Neuromodulation eds E Krames, P H Peckham and A Rezai (London: Elsevier) pp 81-91 [7] Schiff N D, Giacino J T, Kalmar K, Victor J D, Baker K, Gerber M, Fritz B, Eisenberg B, O'Connor J, Kobylarz E J, Farris S, Machado A, McCagg C, Plum F, Fins J J, Rezai A R 2007 Behavioral improvements with thalamic stimulation after severe traumatic brain injury Nature 448 600-3 [8] Schiff N D and Fins J J 2007 Deep brain stimulation and cognition: moving from animal to patient Current Opinion in Neurology 20 638-42 [9] Schiff N D, Giacino J T and Fins J J 2009 Deep brain stimulation, neuroethics and the minimally conscious state: moving beyond proof of principle Arch. Neurology 66 697-702 [10] CMS 160.24 NCD for deep brain stimulation for essential tremor and Parkinson's disease, 1~April~2003 [11] CMS Manual System 100-04 Medicare claims processing, transmittal 128, 26 March 2004 http://www.cms.hhs.gov/Transmittals/Downloads/R128CP.pdf [12] Schwalb J M, Riina H A, Skolnick B, Jaggi J L, Simuni T and Baltuch G H 2001 Revision of deep brain stimulator for tremor: technical note J. Neurosurg. 94 1010-12 [13] Speelman J D and Bosch D A 1998 Resurgence of functional neurosurgery for Parkinson's disease: a historical perspective