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Sample records for soo kim jinsookim

  1. EDRA galeriis SooSoo

    Index Scriptorium Estoniae

    2008-01-01

    Itaalia disainmööbli tootja EDRA tooted on alates 2007. a. detsembrist esindatud galeriis SooSoo. Massimo Morozzi juhtimisel valmivates kollektsioonides on ühendatud moodsad tehnoloogiad ja traditsiooniline käsitöö

  2. State of the SOOS GCMD Portal

    Science.gov (United States)

    Ritz, Scott

    2018-01-01

    A brief status update on NASA’s latest Global Change Master Directory (GCMD) keyword update, description of the differences between DIF-9 and DIF-10 formats in advance of the deprecation of DIF-9 support in Earth Observing System Data and Information System (EOSDIS) with specifics on the DIF-10.3 schema, transition schedule, and some usage metrics for the GCMD Southern Ocean Observing System (SOOS) Portal.

  3. Results from KIMS

    International Nuclear Information System (INIS)

    Myung, S. S.; Bhang, H. C.; Choi, J. H.; Kim, D. W.; Kim, S. C.; Kim, S. K.; Kwak, J. W.; Lee, J.; Lee, J. H.; Lee, M. J.; Lee, S. J.; Ryu, S.; Kang, W. G.; Kim, Y. D.; Lee, J. I.; Jung, S. W.; Kim, H. J.; So, J. H.; Hahn, I. S.; Hwang, M. J.

    2008-01-01

    KIMS is a dark matter search experiment using low background CsI(TB) crystals at Yangyang Underground Laboratory in Korea. With a total exposure of 3409 kg·d data, we set a new limit on WIMP-nucleon cross section. We achieved the most stringent limit on the spin-dependent interaction for a pure proton case. We were able to exclude the DAMA signal region for both spin-dependent and spin-independent interaction for the WIMP mass greater than 20 GeV/c 2 . KIMS experiment is upgraded with 12 CsI(TB) crystals corresponding to a total mass of 104 kg and accumulating data since Jan. 2008.

  4. The ten thousand Kims

    Science.gov (United States)

    Baek, Seung Ki; Minnhagen, Petter; Kim, Beom Jun

    2011-07-01

    In Korean culture, the names of family members are recorded in special family books. This makes it possible to follow the distribution of Korean family names far back in history. It is shown here that these name distributions are well described by a simple null model, the random group formation (RGF) model. This model makes it possible to predict how the name distributions change and these predictions are shown to be borne out. In particular, the RGF model predicts that for married women entering a collection of family books in a certain year, the occurrence of the most common family name 'Kim' should be directly proportional to the total number of married women with the same proportionality constant for all the years. This prediction is also borne out to a high degree. We speculate that it reflects some inherent social stability in the Korean culture. In addition, we obtain an estimate of the total population of the Korean culture down to the year 500 AD, based on the RGF model, and find about ten thousand Kims.

  5. The ten thousand Kims

    International Nuclear Information System (INIS)

    Baek, Seung Ki; Minnhagen, Petter; Kim, Beom Jun

    2011-01-01

    In Korean culture, the names of family members are recorded in special family books. This makes it possible to follow the distribution of Korean family names far back in history. It is shown here that these name distributions are well described by a simple null model, the random group formation (RGF) model. This model makes it possible to predict how the name distributions change and these predictions are shown to be borne out. In particular, the RGF model predicts that for married women entering a collection of family books in a certain year, the occurrence of the most common family name 'Kim' should be directly proportional to the total number of married women with the same proportionality constant for all the years. This prediction is also borne out to a high degree. We speculate that it reflects some inherent social stability in the Korean culture. In addition, we obtain an estimate of the total population of the Korean culture down to the year 500 AD, based on the RGF model, and find about ten thousand Kims.

  6. Monte Carlo lattice program KIM

    International Nuclear Information System (INIS)

    Cupini, E.; De Matteis, A.; Simonini, R.

    1980-01-01

    The Monte Carlo program KIM solves the steady-state linear neutron transport equation for a fixed-source problem or, by successive fixed-source runs, for the eigenvalue problem, in a two-dimensional thermal reactor lattice. Fluxes and reaction rates are the main quantities computed by the program, from which power distribution and few-group averaged cross sections are derived. The simulation ranges from 10 MeV to zero and includes anisotropic and inelastic scattering in the fast energy region, the epithermal Doppler broadening of the resonances of some nuclides, and the thermalization phenomenon by taking into account the thermal velocity distribution of some molecules. Besides the well known combinatorial geometry, the program allows complex configurations to be represented by a discrete set of points, an approach greatly improving calculation speed

  7. Die brein soos beskou deur die Grieke en Romeine

    Directory of Open Access Journals (Sweden)

    Francois P. Retief

    2015-02-01

    Full Text Available In Ou Egipte is mummifikasie met uitgebreide reseksie of uitsnyding van organe geassosieer, maar geen kennis is geneem van die morfologie van die brein nie. Griekse skrywers van die sesde en vyfde eeue v.C. het die brein aanvanklik gesien as die setel van intelligensie, die orgaan van sensoriese waarneming en gedeeltelik die oorsprong van sperma. Pneuma het ’n belangrike rol in breinfunksie gespeel. Hippokrates was die eerste om die brein te beskryf as ’n dubbele orgaan, wat met harsingvlies (meninges bedek, funksioneel van pneuma afhanklik en vertolker van begrip is. Tydgenote soos Plato, Aristoteles en Diokles het tot die beskrywing bygedra, maar laasgenoemde twee het beweer dat die hart die middelpunt van intelligensie is en nie die brein nie. Gedurende die laaste helfte van die vierde eeu v.C. is disseksie van die menslike liggaam tydelik aan die mediese skool van Alexandrië toegelaat en het dit tot merkwaardige vooruitgang in die begrip van die menslike anatomie en fisiologie gelei. Herofilus en Erasistratus het uitstekende beskrywings van die struktuur en funksie van die brein gegee wat eers in die tweede eeu n.C. deur Galenus geëwenaar is.

  8. Introductory Statement by Won-Soo Kim [International Conference on Nuclear Security: Commitments and Actions, Vienna (Austria), 5-9 December 2016

    International Nuclear Information System (INIS)

    Kim, Won-Soo

    2017-01-01

    We need to treat WMD risks and threats holistically. Lessons learned in one area can be emulated in another. The IAEA has learned valuable lessons through its own emergency management work and partnership with other UN agencies, including through the UN Counter-Terrorism Implementation Task Force. These lessons could be beneficial in developing response mechanisms for biological incidents.

  9. Měkkýši Národní přírodní rezervace Soos Molluscs (Mollusca of the Soos National Nature Reserve

    Directory of Open Access Journals (Sweden)

    Jitka Horáčková

    2012-12-01

    Full Text Available The Soos National Nature Reserve nearby Františkovy Lázně Town (Western Bohemia, Czech Republic is a spectacular peatbog site with the occurrence of fens on numerous mineral spring effluents, emanations of pure carbon dioxide in mofettes (i.e. false mud volcanoes, parts with saltwater wetlands, and diatomite mantel in its central part. These natural conditions affect general character of all habitats, vegetation and malacocoenoses in the reserve. Altogether, 31 mollusc species were found there, but only two of them are considered as near threatened (Pisidium obtusale and Vertigo substriata. The majority of recorded assemblage was composed of common and generalist mollusc species.

  10. Kim Dotcomi kättemaks / Andy Greenberg

    Index Scriptorium Estoniae

    Greenberg, Andy

    2013-01-01

    Skandaalne Internetimagnaat Kim Schmitz, rohkem tuntud kui Kim Dotcom, on veendunud, et tema loodud failivahetusprogrammi Megauploadi mahavõtmisega ja autoriõiguste rikkumise süüdistusega tehti talle liiga ning ta on asunud raevukalt vastulöögile USA valitsuse vastu

  11. Projecting Pyongyang: The Future of North Korea's Kim Jong IL Regime

    National Research Council Canada - National Science Library

    Scobell, Andrew

    2008-01-01

    .... In this monograph, the focus is on the fate of the regime dominated by the Kim Dynasty, initially ruled by Kim Il Sung and then led by his son, Kim Jong Il, following the former's death in 1994...

  12. Bonding in Sulfur-Oxygen Compounds-HSO/SOH and SOO/OSO: An Example of Recoupled Pair π Bonding.

    Science.gov (United States)

    Lindquist, Beth A; Takeshita, Tyler Y; Woon, David E; Dunning, Thom H

    2013-10-08

    The ground states (X(2)A″) of HSO and SOH are extremely close in energy, yet their molecular structures differ dramatically, e.g., re(SO) is 1.485 Å in HSO and 1.632 Å in SOH. The SO bond is also much stronger in HSO than in SOH: 100.3 kcal/mol versus 78.8 kcal/mol [RCCSD(T)-F12/AVTZ]. Similar differences are found in the SO2 isomers, SOO and OSO, depending on whether the second oxygen atom binds to oxygen or sulfur. We report generalized valence bond and RCCSD(T)-F12 calculations on HSO/SOH and OSO/SOO and analyze the bonding in all four species. We find that HSO has a shorter and stronger SO bond than SOH due to the presence of a recoupled pair bond in the π(a″) system of HSO. Similarly, the bonding in SOO and OSO differs greatly. SOO is like ozone and has substantial diradical character, while OSO has two recoupled pair π bonds and negligible diradical character. The ability of the sulfur atom to form recoupled pair bonds provides a natural explanation for the dramatic variation in the bonding in these and many other sulfur-oxygen compounds.

  13. Coenite seiklused ja Kim Ki-duki huumor / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

  14. Prikljutshenija Koenov i jumor Kim Ki-duka / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2007-01-01

    60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

  15. The New North Korean Problem: History and Responsibilities in the Age of Kim Jong Un

    Science.gov (United States)

    2012-03-29

    Kim Jong Un is the youngest of Kim Jong Il’s three male children. The oldest, Kim Jong Nam was once favored to...passport.49 In a series of interviews with Japanese reporter Yogi Gomi, Kim Jong Nam related his concerns about the future of North Korea and the...4. TITLE AND SUBTITLE THE NEW NORTH KOREAN PROBLEM: HISTORY AND RESPONSIBILITIES IN THE AGE OF KIM JONG UN 5. FUNDING NUMBERS

  16. Global Policing and the Case of Kim Dotcom

    OpenAIRE

    Darren Palmer; Ian J Warren

    2013-01-01

    In early 2012, 76 heavily armed police conducted a raid on a house in Auckland, New Zealand. The targets were Kim Dotcom, a German national with a NZ residency visa, and several colleagues affiliated with Megaupload, an online subscription-based peer-to-peer (P2P) file sharing facility. The alleged offences involved facilitating unlawful file sharing and United States federal criminal copyright violations. Following the raid, several court cases provide valuable insights into emerging ‘global...

  17. Chang Sei Kim's Activities on Public Health in Colonial Korea

    Directory of Open Access Journals (Sweden)

    Park Yunjae

    2006-12-01

    Full Text Available After graduating from Severance Medical College in 1916, Chang Sei Kim went to Shanghai to work as a missionary in a adventist hospital. The establishment of the Korean Provisional Government led him to participate in the independence movement. Educating nurses to assist the forthcoming war for independence, he seemed to realize the fact that the health of Koreans would be a key factor for achieving independence. He left for the U.S. to conduct comprehensive research on medicine. Chang Sei Kim was the first Korean to receive a Ph. D. degree of Public Health, graduating from the Johns Hopkins School of Hygiene and Public Health in 1925. He then gained an opportunity to work for Korea as a professor at Severance Medical College. His objective was the 'Reconstruction of the Korean People In Terms of Physical Constitution.' He pointed out that Koreans' weak state of health was a major reason for Korea's colonization. To gain independence, he emphasized that the Korean people should receive education on public health in order to improve the primitive conditions of sanitation. There is little doubt that Chang Sei Kim's ideas developed Heungsadan's views on medicine in terms of its stress on cultivation of ability, especially considering the fact that he was a member of the organization. As a member of the colonized who could not participate in the developing official policy, Chang Sei Kim was not able to implement his ideas fully, because an individual or a private organization could not carry out policy on public health as large a scale as the government did. Never giving up his hopes for Korean independence, he rejected requests to assume official posts in the Government-General. That was why he was particularly interested in the Self-Governing Movement in 1920s Korea. If the movement had attained its goal, he might have worked for the enhancement of sanitary environment as a director of Sanitary Department. His application for funding to establish

  18. Anmeldelse af Kim Wind Andersen: Overblik over selskabers underskudsfremførsel

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2011-01-01

    Artiklen anmelder Kim Wind Andersen: Overblik over selskabers underskudsfremførsel (Thomson Reuters Professional, 2010)......Artiklen anmelder Kim Wind Andersen: Overblik over selskabers underskudsfremførsel (Thomson Reuters Professional, 2010)...

  19. Kim C. Sturgess. Shakespeare and the American Nation.

    Directory of Open Access Journals (Sweden)

    Jean‑Louis Claret

    2006-04-01

    Full Text Available The front page of Kim C Sturgess’s recent book entitled Shakespeare and the American Nation is particularly mind‑teasing insofar as it represents the famous Droeshout engraving of the bard (it illustrated the front‑page of the 1623 edition of Shakespeare’s works standing out against a background that superimposes the head of the Statue of Liberty on the spangled banner. The starting point of Sturgess’s 234‑page demonstration endorsed by Cambridge University Press is a paradox that the Britis...

  20. Kim C. Sturgess. Shakespeare and the American Nation.

    OpenAIRE

    Claret, Jean‑Louis

    2006-01-01

    The front page of Kim C Sturgess’s recent book entitled Shakespeare and the American Nation is particularly mind‑teasing insofar as it represents the famous Droeshout engraving of the bard (it illustrated the front‑page of the 1623 edition of Shakespeare’s works) standing out against a background that superimposes the head of the Statue of Liberty on the spangled banner. The starting point of Sturgess’s 234‑page demonstration endorsed by Cambridge University Press is a paradox that the Britis...

  1. Sexualidad violenta en el cine de Kim Ki-duk

    Directory of Open Access Journals (Sweden)

    Daniel Muñoz Ruiz

    2011-07-01

    Full Text Available En sus más de 110 años de vida el cine ha representado la sexualidad humana en todas sus modalidades y desde los más variados puntos de vista. El cine de Kim Ki-duk ha sorprendido y escandalizado al público por su crudeza y, a veces, excesiva violencia. El director surcoreano ha explorado a lo largo de su filmografía el tema del sexo siempre desde puntos de vista dramáticos y hasta truculentos. En sus películas la mayoría de las relaciones sexuales carecen de amor y afecto. Nunca son placenteras. La violación, la prostitución, la violencia de género y las frustraciones sexuales son temas recurrentes en su cine.

  2. Materialismo percettivo. Da Democrito a Lenin, da Hobbes a Kim

    Directory of Open Access Journals (Sweden)

    Michele Gardini

    2012-05-01

    Full Text Available The paper tries to outline something like a short “critique of pure materialism” in the domain of perception, a sketch showing – through a series of examples, picked out in an apparently heterogeneous fashion from the Western philosophical tradition – how this epistemological model each time, and in everyone of its forms, fails in giving account of the basic features of perceiving.  After giving a survey of authors like Democritus, Hobbes, De Sade, Lenin, the final appendix, devoted to the concept of “supervenience” and its treatment in Davidson and Kim, aims at summarizing the whole problem through the categories of the contemporary philosophy of mind. The conclusion is that a pure materialistic approach is incapable to give reason to some of the fundamental characteristics of perception, that make it one of the basic moods of “being-in-the-world”.

  3. Global Policing and the Case of Kim Dotcom

    Directory of Open Access Journals (Sweden)

    Darren Palmer

    2013-11-01

    Full Text Available In early 2012, 76 heavily armed police conducted a raid on a house in Auckland, New Zealand. The targets were Kim Dotcom, a German national with a NZ residency visa, and several colleagues affiliated with Megaupload, an online subscription-based peer-to-peer (P2P file sharing facility. The alleged offences involved facilitating unlawful file sharing and United States federal criminal copyright violations. Following the raid, several court cases provide valuable insights into emerging ‘global policing’ practices (Bowling and Sheptycki 2012 based on communications between sovereign enforcement agencies.  This article uses these cases to explore the growth of ‘extraterritorial’ police powers that operate ‘across borders’ (Nadelmann 1993 as part of several broader transformations of global policing in the digital age.

  4. Magnetic flux creep in HTSC and Anderson-Kim theory

    International Nuclear Information System (INIS)

    Lykov, A.N.

    2014-01-01

    The theoretical and experimental data on flux creep in high-temperature superconductors (HTSC) were analyzed in the review paper. On the one hand, the main attention is paid to the most striking experimental results which have had a significant influence on the investigations of flux creep in HTSC. On the other hand, the analysis of theoretical studies is concentrated on the works, which explain the features of flux creep on the basis of the Anderson-Kim (AK) theory modifications, and received previously unsufficient attention. However, it turned out that the modified AK theory could explain a lot of features of flux creep in HTSC: the scaling behaviour of current-voltage curves of HTSC, the finite rate of flux creep at ultra low temperatures, the logarithmic dependence of effective pinning potential as a function of transport current and its decrease with temperature. The harmonic potential field which is used in this approach makes it possible to solve accurately the both problems: viscous vortex motion and flux creep in this field. Moreover the distribution of pinning potential and the interaction of vortices with each other are taken into account in the approach. Thus, the modification of the AK theory consists, essentially, in its detailed elaboration and approaching to real situations in superconductors

  5. A STUDY OF MICROBES IN FRUIT JUICES, KIMS-AMALAPURAM

    Directory of Open Access Journals (Sweden)

    Nagaraja

    2015-12-01

    Full Text Available INTRODUCTION Fruit and sugarcane juices are nutritious drinks with great taste and health benefits. Food borne illnesses associated with consumption of Fruit and sugarcane juices at several places in India and elsewhere. Fruit juices were served with added ice pieces. Hygienic standards are not maintained while transporting from the field to the place of extraction and preparation. Hence a rapid review of the fruit juices from street vendors has been undertaken along with sugarcane juice. Raw sugarcane juice is a refreshing juice in many parts of Andhra Pradesh. The present study is to assess the prevalence of different organisms from different fruit juices collected from street vendors. METHODS Fruit juices are collected namely sugarcane, sweet lemon, orange, grape apple, pineapple pomegranate. A total 100 samples of fruit juices were collected from road side from different vendors. 150 ml of each variety of fruit juices were collected from different vendors in screw capped bottles and subjected to microbial analysis, processed with in 30mts in the department of microbiology at KIMS by standard methods. RESULTS The analysed samples of fruit juices are found to be contaminated with different bacteria, Escherichia coli 30% Klebsiella pneumoniae 10% Staphylococcus aureus 20% Enterococcus faecalis 04% Pseudomonas aeruginosa 10% ASB 04% (aerobic spore bearers Micrococci 02% Proteus 20% Salmonella. Shigella and Vibrios were not isolated. CONCLUSION It is high time that street vendors should have health education by volunteers, health workers from PHC (primary health centers and people well versed with community medicine practice for implementation of standard hygienic protocols may reduce contamination of fruit and sugarcane juices The concerned health authorities need to ensure and insist to follow the protocols by the vendors and license holders to the vendors.

  6. REPRESENTATION OF KIM JONG-UN’S SUCCESSION IN BBC NEWS: A CRITICAL DISCOURSE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Hendra Nugraha

    2016-04-01

    Full Text Available This research attempts to reveal representation of Kim Jong-Un’s succession in BBC News through textual and discursive practice analysis. The data of this thesis are taken from BBC News website on 29 and 31 December 2011. The theory applied to seek the objective of the research is Critical Discourse Analysis developed by Fairclough. Through textual and discursive practice analysis, the writer finds pthat BBC employs more passive material clauses than active material clauses in depicting Kim Jong-Un’s succession. BBC also represents Kim Jong-Un’s succession as premature process where Kim Jong-Un is portrayed as a young and inexperienced leader. Besides the prematurity of the succession, the present writer finds that BBC represents Kim Jong-Un’s succession as continuity of Kim’s family dynasty. Thus, the succession is based on his resemblance to Kim Il-Sung, the founder of Democratic People’s Republic of Korea, rather than Kim Jong-Un ability and competency.

  7. [Status of diagnosis and treatment devices of acupuncture based on SooPAT and bibliometrics in China].

    Science.gov (United States)

    Bai, Lin; Ren, Yulan; Guo, Taipin; Chen, Lin; Zhou, Yumei; Feng, Shuwei; Li, Ji; Liang, Fanrong

    2016-11-12

    To perform a bibliometrics analysis on patent literature regarding diagnosis and treatment devices of acupuncture in China, aiming to provide references for the development of diagnosis and treatment devices of acupuncture. Based on SooPAT, a patent database, the patent literature regarding diagnosis and treatment devices of acupuncture in China was collected. With bibliometrics methods, the annual distribution of type, quantity, classification and content of diagnosis and treatment devices of acupuncture were analyzed. The number of acupuncture diagnosis and treatment devices reached its peak in 2012 and 2013 in China. The A61N in patent and utility model patent were the most, which were mainly related to electrotherapy, magnetic therapy, radioactive therapy and ultrasound therapy, etc. The main content was acupuncture treatment devices and meridian treatment devices. The 24-01 in design patent was the most, involving fixation devices used by doctors, hospitals and laboratories, etc. Currently the majority of diagnosis and treatment devices of acupuncture is therapeutic apparatus, while the acupuncture diagnosis devices are needed.

  8. [KIM-1 and NGAL as potential biomarkers for the diagnosis and cancer progression].

    Science.gov (United States)

    Marchewka, Zofia; Tacik, Aneta; Piwowar, Agnieszka

    2016-04-18

    On the basis of scientific literature, there is growing evidence that KIM-1 and NGAL are interesting and promising biomarkers not only in acute and chronic inflammatory processes but also in oncogenesis. There are a number of studies which investigate their possible use in diagnosis, treatment and monitoring of therapy effectiveness. The results of recent research suggests that they may play an important role in standard oncology practice. Simultaneous measurement of KIM-1 and NGAL in urine can play a crucial role in carcinogenesis assessment and cancer progression. In the future, they can become rapid diagnostic indicators, which allow one to determine cancer subtype leading to biopsy replacement and therapy improvement. In the present work, beside biochemical characteristics of KIM-1 and NGAL, we will also discuss their role in the diagnosis and assessment of development of cancer.

  9. KIM-1 and NGAL as potential biomarkers for the diagnosis and cancer progression

    Directory of Open Access Journals (Sweden)

    Zofia Marchewka

    2016-04-01

    Full Text Available On the basis of scientific literature, there is growing evidence that KIM-1 and NGAL are interesting and promising biomarkers not only in acute and chronic inflammatory processes but also in oncogenesis. There are a number of studies which investigate their possible use in diagnosis, treatment and monitoring of therapy effectiveness. The results of recent research suggests that they may play an important role in standard oncology practice. Simultaneous measurement of KIM-1 and NGAL in urine can play a crucial role in carcinogenesis assessment and cancer progression. In the future, they can become rapid diagnostic indicators, which allow one to determine cancer subtype leading to biopsy replacement and therapy improvement. In the present work, beside biochemical characteristics of KIM-1 and NGAL, we will also discuss their role in the diagnosis and assessment of development of cancer.

  10. Bridging communication between public and government: a case study on kim surabaya

    Science.gov (United States)

    Aji, G. G.; Tsuroyya; Dewi, P. A. R.

    2018-01-01

    In democratic era, the public communication paradigm has shifted from a one-way socialization to more interactive one. As a consequence of freedom of speech, the public can Actively communicate with the government and vice versa. The problem is government is almost impossible to reach all public groups. Therefore, they has created the concept of social institutions as a communication hub between the government and its public, named the Kelompok Informasi Masyarakat (KIM). This research examines the activity of KIM in Surabaya on bridging public between government and the public. Using a case study approach, this research utilized various techniques of data collection such as: interviews, observation, and documentation. The results Showed that KIM plays a role in the two-way flow of information; to diseminate program and submit complaints and suggestions from the public about the policy. This study confirm the urgency of utilization on various channels in communicating with the public.

  11. Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers

    Directory of Open Access Journals (Sweden)

    Mijušković Mirjana

    2016-01-01

    Full Text Available Background/Aim. Kidney injury molecule-1 (KIM-1 and aquaporin-1 (AQP-1 are potential early urinary biomarkers of clear renal cell carcinoma (cRCC. The aim of this study was to ascertain relationship between the urine concentrations KIM-1 and AQP-1 with tumor size, grade, pT stage and type of operation (radical or partial nephrectomy in patients with cRCC. Methods. Urinary concentrations of urinary KIM-1 (uKIM-1 and urinary AQP-1 (uAQP-1 were determined by commercially available ELISA kits. The analysis included 40 patients undergoing partial or radical nephrectomy for cRCC and 40 age- and sex-matched healthy adult volunteers. Results. The median preoperative concentrations of KIM-1 in the cRCC group [0.724 ± 1.120 ng/mg urinary creatinine (Ucr] were significantly greater compared with controls (healthy volunteers (0.210 ± 0.082 ng/mgUcr (p = 0.0227. Postoperatively, uKIM-1 concentration decreased significantly to control values (0.177 ± 0.099 ng/mgUcr vs 0.210 ± 0.082 ng/mgUcr, respectively. The size, grade and stage of tumor were correlated positively with preoperative uKIM-1 concentrations. Contrary to these results, concentrations of uAQP-1 in the cRCC group were significantly lower (0.111 ± 0.092 ng/mgUcr compared with the control group (0.202 ± 0.078 ng/mgUcr (p = 0.0014. Postoperatively, the concentrations of uAQP-1 increased progressively up to control values, approximately. We find no significant correlation between preoperative uAQP-1 concentrations and tumor size, grade and stage. Conclusion. uKIM-1 was found to be a reliable diagnostic marker of cRCC, based on its significantly increased values before and decreased values after the nephrectomy. [Projekat Ministarstva nauke Republike Srbije, br. III41018

  12. Against the Nihilism of Suffering and Death: Richard E. K. Kim and His Works

    Directory of Open Access Journals (Sweden)

    Jooyeon Rhee

    2016-03-01

    Full Text Available This article examines the life and works of Richard E. K. Kim (1932–2009, a first-generation Korean diasporic writer in the United States. It focuses on how Kim struggled to overcome the nihilism of suffering and death that derived from colonialism and the Korean War through his literary works. Kim witnessed firsthand these two major historical events, which caused irrevocable psychological and physical damage to many people of his generation. In his autobiographical fiction, he conveys painful memories of the events by reviving the voices of people in that era. What his works offer us goes beyond vivid memories of the past, however; they also present the power of forgiveness as a condition to overcome the nihilism of suffering and death. Remembrance and forgiveness are, therefore, two major thematic pillars of his works that enable us to connect to these difficult and traumatic times. These themes are portrayed in such a gripping way mainly because Kim tried to maintain a certain distance—an emotional and linguistic distance—from the familiar, in order to elucidate the reality of the human condition: an ontological position of the exile from which he produced his works. This article argues that Kim’s works provide us the possibility to transcend the nihilism of historical trauma through articulating the meaning of remembrance and forgiveness from his self-assumed position of exile.

  13. Non-integrability of the Armbruster-Guckenheimer-Kim quartic Hamiltonian through Morales-Ramis theory

    OpenAIRE

    Acosta-Humánez, P.; Alvarez-Ramírez, M.; Stuchi, T.

    2017-01-01

    We show the non-integrability of the three-parameter Armburster-Guckenheimer-Kim quartic Hamiltonian using Morales-Ramis theory, with the exception of the three already known integrable cases. We use Poincar\\'e sections to illustrate the breakdown of regular motion for some parameter values.

  14. Arhitektuurimuuseum vaatab Aasiasse / Kim Sung Hong ; intervjueerinud Karin Hallas-Murula

    Index Scriptorium Estoniae

    Kim Sung Hong

    2009-01-01

    Näituse kuraatori Kim Sung Hongiga 21. aprillini Eesti Arhitektuurimuuseumis avatud Lõuna-Korea kaasaegse arhitektuuri näitusest "Megacity network" ("Megalinna võrgustik"), Korea arhitektuurist, arhitektidest, muinsuskaitsest ja avalikust ruumist. Näituse kujundas Hwang Doo Jin

  15. A Misleading Review of Response Bias: Comment on McGrath, Mitchell, Kim, and Hough (2010)

    Science.gov (United States)

    Rohling, Martin L.; Larrabee, Glenn J.; Greiffenstein, Manfred F.; Ben-Porath, Yossef S.; Lees-Haley, Paul; Green, Paul; Greve, Kevin W.

    2011-01-01

    In the May 2010 issue of "Psychological Bulletin," R. E. McGrath, M. Mitchell, B. H. Kim, and L. Hough published an article entitled "Evidence for Response Bias as a Source of Error Variance in Applied Assessment" (pp. 450-470). They argued that response bias indicators used in a variety of settings typically have insufficient data to support such…

  16. Lõuna-Korea teatel võib Kim peagi surra / Evelyn Kaldoja

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2009-01-01

    Viidates Lõuna-Korea ja Hiina luureandmetele, väidab Lõuna-Korea meedia, et Põhja-Korea liidril Kim Jong-ilil on kõhunäärmevähk ja talle pole antud elada rohkem kui 5 aastat. Põhja-Korea valitsejadünastia

  17. North Korean Leadership Dynamics and Decision-making under Kim Jong-un: A Second Year Assessment

    Science.gov (United States)

    2014-03-01

    Kim Kyong-hui was critically ill. Kim has a reported history of alcoholism and depression , which was exacerbated in the mid-2000s with her mari- tal...problems and the death of her daughter, Jang Kum-song, who com- mitted suicide in 2006. Some reports claim that she is also suffering from... teens , were

  18. The diagnostic importance of the new marker KIM-1 in kidney damage

    Directory of Open Access Journals (Sweden)

    Zofia Marchewka

    2013-07-01

    Full Text Available In recent years, the rapid development of scientific research led to the introduction of strategies based on new markers that allow for estimation of the latent disease period before the clinical symptoms of actual kidney failure are revealed.The experimental tests carried out on animals and cell lines derived from the proximal tubule have made possible the detection of genes that are induced early after hypoxia [1].The protein products of these genes can be considered as useful markers for the diagnosis of renal failure. The induction of gene KIM-1 (called Kidney Injury Molecule-1 results in the formation of protein that can be considered as a diagnostic marker.This work describes the data on the structure, biological function and importance of determining the concentrations of KIM-1 in the diagnosis of drug-induced toxicity and kidney damage.

  19. [The diagnostic importance of the new marker KIM-1 in kidney damage].

    Science.gov (United States)

    Marchewka, Zofia; Płonka, Joanna

    2013-07-24

    In recent years, the rapid development of scientific research led to the introduction of strategies based on new markers that allow for estimation of the latent disease period before the clinical symptoms of actual kidney failure are revealed. The experimental tests carried out on animals and cell lines derived from the proximal tubule have made possible the detection of genes that are induced early after hypoxia. The protein products of these genes can be considered as useful markers for the diagnosis of renal failure. The induction of gene KIM-1 (called Kidney Injury Molecule-1) results in the formation of protein that can be considered as a diagnostic marker. This work describes the data on the structure, biological function and importance of determining the concentrations of KIM-1 in the diagnosis of drug-induced toxicity and kidney damage.

  20. Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus.

    Directory of Open Access Journals (Sweden)

    In O Sun

    Full Text Available The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL and kidney injury molecule-1 (KIM-1 for acute kidney injury (AKI in patients with scrub typhus.From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least 3 months. We measured serum and urine NGAL and KIM-1 levels and evaluated prognostic factors affecting scrub typhus-associated AKI.Of the 138 patients, 25 had scrub typhus-associated AKI. The incidence of AKI was 18.1%; of which 11.6%, 4.3%, and 2.2% were classified as risk, injury, and failure, respectively, according to RIFLE criteria. Compared with patients in the non-AKI group, patients in the AKI group were older and showed higher total leukocyte counts and hypoalbuminemia or one or more comorbidities such as hypertension (72% vs 33%, p<0.01, diabetes (40% vs 14%, p<0.01, or chronic kidney disease (32% vs 1%, p<0.01. In addition, serum NGAL values (404± 269 vs 116± 78 ng/mL, P<0.001, KIM-1 values (0.80± 0.52 vs 0.33± 0.68 ng/mL, P<0.001, urine NGAL/creatinine values (371± 672 vs 27± 39 ng/mg, P<0.001 and urine KIM-1/creatinine values (4.04± 2.43 vs 2.38± 1.89 ng/mg, P<0.001 were higher in the AKI group than in the non-AKI group. By multivariate logistic regression, serum NGAL and the presence of chronic kidney disease were significant predictors of AKI.Serum NGAL might be an additive predictor for scrub typhus-associated AKI.

  1. North Korea after Kim Chong-il: Leadership Dynamics and Potential Crisis Scenarios

    Science.gov (United States)

    2011-11-01

    legal responsibility, and with specified procedures , the actual process is different.3 To date, regime dynamics in the Kim Chong-il era have been... procedures and regulations provide the outlines of formal rule, the 3 For a detailed examination of how...was also made an alternate member. It is also worth noting that 10 of the 12 members of the NDC were represented in the new Politburo lineup , thus

  2. The first clinical treatment with kilovoltage intrafraction monitoring (KIM): A real-time image guidance method

    DEFF Research Database (Denmark)

    Keall, Paul J.; Aun Ng, Jin; O'Brien, Ricky

    2015-01-01

    on September 16, 2014. Methods: KIM uses current and prior 2D x-ray images to estimate the 3D target position during cancer radiotherapy treatment delivery. KIM software was written to process kilovoltage (kV) images streamed from a standard C-arm linear accelerator with a gantry-mounted kV x-ray imaging...... system. A 120° pretreatment kV imaging arc was acquired to build the patient-specific 2D to 3D motion correlation. The kV imager was activated during the megavoltage (MV) treatment, a dual arc VMAT prostate treatment, to estimate the 3D prostate position in real-time. All necessary ethics, legal......, and regulatory requirements were met for this clinical study. The quality assurance processes were completed and peer reviewed. Results: During treatment, a prostate position offset of nearly 3 mm in the posterior direction was observed with KIM. This position offset did not trigger a gating event. After...

  3. Ab initio and Gordon--Kim intermolecular potentials for two nitrogen molecules

    International Nuclear Information System (INIS)

    Ree, F.H.; Winter, N.W.

    1980-01-01

    Both ab initio MO--LCAO--SCF and the electron-gas (or Gordon--Kim) methods have been used to compute the intermolecular potential (Phi) of N 2 molecules for seven different N 2 --N 2 orientations. The ab initio calculations were carried out using a [4s3p] contracted Gaussian basis set with and without 3d polarization functions. The larger basis set provides adequate results for Phi>0.002 hartree or intermolecular separations less than 6.5--7 bohr. We use a convenient analytic expression to represent the ab initio data in terms of the intermolecular distance and three angles defining the orientations of the two N 2 molecules. The Gordon--Kim method with Rae's self-exchange correction yields Phi, which agrees reasonably well over a large repulsive range. However, a detailed comparison of the electron kinetic energy contributions shows a large difference between the ab initio and the Gordon--Kim calculations. Using the ab initio data we derive an atom--atom potential of the two N 2 molecules. Although this expression does not accurately fit the data at some orientations, its spherical average agrees with the corresponding average of the ab initio Phi remarkably well. The spherically averaged ab initio Phi is also compared with the corresponding quantities derived from experimental considerations. The approach of the ab initio Phi to the classical quadrupole--quadrupole interaction at large intermolecular separation is also discussed

  4. North Korean Leadership Dynamics and Decision-making under Kim Jong-un: A First Year Assessment

    Science.gov (United States)

    2013-09-01

    Kim Jong-un’s ’Sick’ Aunt Resurfaces,” Chosun Ilbo Online, 27 July 2013. Kim has a reported history of alcoholism and depression , which was...exacer- bated in the mid-2000s with her marital problems and the death of her daughter, Jang Kum-song, who committed suicide in 2006. Some reports claim...the Party and state apparatus. She was born in 1974, and, when in her teens , began work in Kim Il-sung’s Presidential Office. She moved over to the

  5. Urinary NGAL, KIM-1 and L-FABP concentrations in antenatal hydronephrosis.

    Science.gov (United States)

    Noyan, Aytul; Parmaksiz, Gonul; Dursun, Hasan; Ezer, Semire Serin; Anarat, Ruksan; Cengiz, Nurcan

    2015-10-01

    The clinical tests currently in use for obstructive nephropathy (such as renal ultrasonography, differential radionuclide renal scans and urinary creatinine concentration data) are not efficient predictors of the subsequent clinical course. Novel and simple biomarkers are required which, if proven, could be clinically beneficial in determining if a patient is eligible for surgery or reno-protective therapy. More recently, the interest of clinicians has focused on the potential of urinary neutrophil gelatinase-associated lipocalin (uNGAL), urinary kidney injury molecule-1 (uKIM-1) and urinary liver-type fatty acid-binding proteins (uL-FABP) as biomarkers for renal function in children with hydronephrosis (HN). The purpose of this study was to investigate possible clinical applications of uNGAL, uKIM-1 and uL-FABP as beneficial non-invasive biomarkers to determine whether or not surgical intervention is required in children with HN. Renal ultrasonography and radionuclide renal scans were used as diagnostic tools to detect HN. Patients were divided into two groups based on the antero-posterior diameter of their renal pelvis and the presence of dysfunction. Group 1 included 26 children with severe HN (with dysfunction), and group 2 consisted of 36 children with mild HN (without dysfunction). Urine samples were collected from 62 children with HN and 20 healthy children. Hydronephrosis was more common in males than in females, with a male to female ratio of 9:1 in the study sample. The incidence of left kidney involvement (32 patients) was slightly higher than right kidney involvement (28 patients). Compared with controls and group 2, the ratio of uNGAL to creatinine was significantly higher in group 1 (p hydronephrosis and dysfunction had significantly increased uNGAL, and uNGAL/Cr concentrations. However, uKIM-1, uKIM-1/Cr, uL-FABP and uL-FABP/Cr concentrations were not significantly different when compared with controls. These results support the use of u

  6. Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus.

    Science.gov (United States)

    Sun, In O; Shin, Sung Hye; Cho, A Young; Yoon, Hyun Ju; Chang, Mi Yok; Lee, Kwang Young

    2017-01-01

    The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for acute kidney injury (AKI) in patients with scrub typhus. From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least 3 months. We measured serum and urine NGAL and KIM-1 levels and evaluated prognostic factors affecting scrub typhus-associated AKI. Of the 138 patients, 25 had scrub typhus-associated AKI. The incidence of AKI was 18.1%; of which 11.6%, 4.3%, and 2.2% were classified as risk, injury, and failure, respectively, according to RIFLE criteria. Compared with patients in the non-AKI group, patients in the AKI group were older and showed higher total leukocyte counts and hypoalbuminemia or one or more comorbidities such as hypertension (72% vs 33%, pscrub typhus-associated AKI.

  7. Children on Social Media, Twiter and Facebook (profile of Beyonce and Kim Kardashian

    Directory of Open Access Journals (Sweden)

    Anamarija Bilan

    2017-09-01

    Full Text Available Publishing children’s photos in the media violates their privacy right, which is protected, guaranteed and regulated by numerous international and Croatian laws and regulations. Likewise, publishing photos of children on social network profiles, such as Facebook or Twitter, violates the right to privacy. In this paper it will be researched the extent to which children’s photos are being disclosed and their privacy is being undermined in case of two Facebook and two Twitter profiles - Beyonce Knowles and Kim Kardashian. It will also research whether children are used for business purposes, whether they are advertising some of their products or shows, and so on, with the photographs of children. The content analysis methodology analyzed the Facebook and Twitter profiles of two respondents in the period from January 1 to February 22, 2016, during which they published a total of 459 posts on profiles of both networks. The analysis found that the total number of “posts” shows a small number of photographs of children but also that those published by Kim Kardashian are often used to promote or promote some of the products or programs, which violates the privacy of children and increases the number “like”.

  8. Prospects for 6-party talks: Nuclear weapons are a means of survival for Kim Jong Un

    International Nuclear Information System (INIS)

    Miyake, Kunihiko

    2012-04-01

    The author considers the impact of leader Kim Jong Il's death on 6-party talks surrounding the nuclear issue. Firstly, the history of these 6-party talks has to be reexamined to ensure an accurate understanding of their 'objectives and limitations' because the author believes that there are 3 'unpleasant truths' behind these talks, held 6 times since the summer of 2003, that no one wants to talk about. 1. North Korea has no interest in abandoning nuclear weapons; 2. Japan, the U.S., China, and South Korea do not want war; 3. The nuclear issue will not be resolved by 6-party talks. In fact, there is little potential that 6-party talks which aim to resolve the North Korean nuclear issue will move towards a new substantive agreement

  9. Data and statistical summaries of background concentrations of metals in soils and streambed sediments in part of Big Soos Creek drainage basin, King County, Washington

    Science.gov (United States)

    Prych, E.A.; Kresch, D.L.; Ebbert, J.C.; Turney, G.L.

    1995-01-01

    Twenty-nine soil samples from 14 holes at 9 sites in part of the Big Soos Creek drainage basin in southwest King County, Washington, were collected and analyzed to obtain data on the magnitude and variability of background concentrations of metals in soils. Seven streambed-sediment samples and three streamwater samples from three sites also were collected and analyzed. These data are needed by regulating government agencies to determine if soils at sites of suspected contamination have elevated concentrations of metals, and to evaluate the effectiveness of remediation at sites with known contamination. Concentrations of 43 metals were determined by a total method, and concentrations of 17 metals were determined by a total-recoverable method and two different leaching methods. Metals analyzed for by all methods included most of those on the U.S. Environmental Protection agency list of priority pollutants, plus alluminum, iron, and manganese. Ranges of concentrations of metals determined by the total method are within ranges found by others for the conterminous United States. Concentrations of mercury, manganese, phosphorus, lead, selenium, antimony, and zinc as determined by the total method, and of some of these plus other metals as determined by the other methods were larger in shallow soil (less than 12 inches deep) than in deep soil (greater than 12 inches). Concentrations of metals in streambed sediments were more typical of shallow than deep soils.

  10. Social influence of a religious hero: the late Cardinal Stephen Kim Sou-hwan's effect on cornea donation and volunteerism.

    Science.gov (United States)

    Bae, Hyuhn-Suhck; Brown, William J; Kang, Seok

    2011-01-01

    This study examined the mediated influence of a celebrated religious hero in South Korea, Cardinal Stephen Kim, through two forms of involvement--parasocial interaction and identification--on intention toward cornea donation and volunteerism, and it investigated how the news media diffused of his death. A structural equation modeling analysis with a Web-based voluntary survey of more than 1,200 people in South Korea revealed a multistep social influence process, beginning with parasocial interaction with Cardinal Kim, leading to identification with him, which predicted intention toward cornea donation and volunteerism. Additional investigations found that news of Cardinal Kim's death diffused rapidly through media and interpersonal communication. Results of this study demonstrate that religious leaders who achieve a celebrity hero status can prompt public discussion of important issues rather quickly through extensive media coverage, enabling them to promote prosocial behavior and positively affect public health.

  11. Die dagboek van Bertha Marks as ‘n heterotopia, soos verwoord in die kunswerk, The Futility of Writing 24-Page Letters

    Directory of Open Access Journals (Sweden)

    Leora Farber

    2012-11-01

    Full Text Available Hierdie artikel ondersoek die konsepsie, historiese konteks en teoretiese raamwerk van Leora Farber se 2010 kunswerk The Futility of Writing 24-Page Letters wat ‘n voortsetting is van haar uitstalling Dis-Location/Re-Location. The Futility of Writing 24-Page Letters val binne die tematiek van Dis-Location/Re-Location, maar beklemtoon één aspek van laasgenoemde, naamlik hoe fin-de-siècle Joodse koloniale immigrante vrouens in Suiderlike-Afrika – soos versinnebeeld in die persona van Bertha Marks (1862–1934 – negentiende-eeuse, Viktoriaanse genderideologieë ervaar het. Hierdie vrouens se lewenservarings het dikwels verset teenoor hul posisies as subjekte van ‘n patriargale sosiale sisteem behels, tog, as vrouens, was hul tegelykertyd medepligtig aan die onderskraging van diskriminerende koloniale ideologieë, en aan die handhawing van die rasse, sosiale en kulturele vooroordele, asook vorms van onderdrukking, wat hierdie ideologieë ingelig het. Daar word geargumenteer dat Bertha Marks ‘n verpersoonlikte heterotopia bewoon het; terwyl sy haar plek binne die struktuur van die rasse- en sosiale vooroordele van die koloniale tydperk ten volle ingeneem het, was sy terselfdertyd beperk deur haar posisionering binne dié raamwerk. Hierdie heterotopiese lewenservaring word weerspieël in die dagboekuittreksels waaruit The Futility of Writing 24-Page Letters bestaan. Daarin word haar teenstrydige posisies as slagoffer, getuie, bystander, meeloper en begunstigde van koloniale onreg en uitbuiting geopenbaar, en aanvaar sy in wisselende mate mede-verantwoordelikheid en mede-aanspreeklikheid vir haar rol en optrede.

  12. Moral is political Notions of ideal citizenship in Lie Kim Hok’s Hikajat Khonghoetjoe

    Directory of Open Access Journals (Sweden)

    Evi Sutrisno

    2017-04-01

    Full Text Available This paper argues that the Hikajat Khonghoetjoe (The life story of Confucius, written by Lie Kim Hok in 1897, is a medium to propose modern ideas of flexible subjectivity, cosmopolitanism, active citizenship and the concepts of good governance to the Chinese Peranakans who experienced political and racial discrimination under Dutch colonization. Using the figure of Confucius, Lie aimed to cultivate virtuous subjects who apply their faith and morality in political sphere. He intended to raise political awareness and rights among the Chinese as colonial subjects and to valorize their bargaining power with the Dutch colonial government. By introducing Confucianism, Lie proposed that the Chinese reconnect themselves with China as an alternative patronage which could subvert White supremacy. Instead of using sources in Chinese, Lie translated the biography of Confucius from the European texts. In crafting his story, Lie applied conglomerate authorship, a technique commonly practised by Malay authors. It allowed him to select, combine and appropriate the source texts. To justify that Confucius' virtue and his teaching were superb and are applicable to contemporary life, Lie borrowed and emphasized European writers’ high appraisal of Confucianism, instead of using his own arguments and opinions. I call this writing technique “indirect agency”.

  13. "Sundiata, Lion King of Mali." Adapted by Kim Hines, Featuring Griot Alhaji Papa Susso, Cue Sheet for Students.

    Science.gov (United States)

    Freeman, Aakhu TuahNera

    This performance guide is designed for teachers to use with students before and after a performance of "Sundiata: Lion King of Mali," adapted by Kim Hines and featuring Griot Alhaji Papa Susso. The guide, called a "Cuesheet," contains seven activity sheets for use in class, addressing: (1) Sundiata: Man & Myth (discusses…

  14. Kim Wŏn-haeng’s Intellectual Influences on Hong Tae-yong: The Case of Relations between

    Directory of Open Access Journals (Sweden)

    Login Lok-yin Law

    2015-08-01

    Full Text Available In the 18th century Chosŏn (1392-1910, some scholars, such as Hong Tae-yong (1731-1783 advocated that Chosŏn should learn the advantages of the Qing (1644-1912 society to reform the social structure and government of Chosŏn. The school of these advocates has been known as Pukhak by historians. The intellectual factors of the school of Pukhak’s formation and development have been overlooked by the academia of Chosŏn intellectual history. In fact, Pukhak was closely related to the idea of the school of Nakhak which believed that nature of things was equivalent to humans. Kim Wŏn-haeng, was one of the supporters of Nakhak and Hong Tae-yong was one of the students of Kim. Hong’s thought and writing exposed that his thought was profoundly influenced by Kim Wŏn-haeng. Hong was deemed to be the first prominent scholar of the Pukhak School during the 18th century Chosŏn. Hong and other scholars of Pukhak advocated learning the new knowledge from Qing China even though it was a barbarian society. Therefore, this paper will investigate the intellectual relationships between Hong Tae-yong and Kim Wŏn-haeng to reveal how intellectuals of Nakhak shaped the formation of Pukhak School and exposed the idea of learning from Qing China.

  15. Language and Family Dispersion: North Korean Linguist Kim Su-gyŏng and the Korean War

    Directory of Open Access Journals (Sweden)

    Ryuta Itagaki

    2017-03-01

    Full Text Available This article analyzes the unpublished memoir of Kim Su-gyŏng (1918–2000, a linguist who was active in North Korea from the mid-1940s until the late 1960s, and situates his account of his experience of the Korean War within the context of his linguistic essays and correspondence. In doing so, the article considers the role that the personal and the social play in language, utilizing Saussure’s theoretical framework, with which Kim himself was well versed. Kim wrote his memoirs in the 1990s to his family, from whom he had become separated during the Korean War and who now lived in Toronto. In this text, he writes in “personal” language that reveals his uncertainty and his feelings for his family, but then immediately negates these feelings through the use of “social” language, which resonates with his interpretation of the linguistic thesis that Josef Stalin developed during the Korean War on language and national identity. For Kim, the relationship between language and nation was not at all self-evident, but something that he idealized in response to the dispersal of his family. By offering a reflexive reading of a memoir written by a North Korean linguist, this article makes a breakthrough in the investigation of North Korean wartime academic history, which has not risen above the level of analyzing articles in the field of linguistics that were published at the time.

  16. A STUDY OF METABOLIC SYNDROME IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY AT KIMS HOSPITAL, HUBBALLI, KARNATAKA, INDIA

    Directory of Open Access Journals (Sweden)

    Chandrashekar K

    2018-01-01

    Full Text Available BACKGROUND Coronary heart disease has become an epidemic since 20th century. Deaths due to the same are increasing of around 17.5 million deaths in year 2012. The deaths are increasing more in developing countries and metabolic syndrome is a cluster of disorders, which are promoting the development of coronary artery diseases. The disorders include central obesity, insulin resistance, dyslipidaemia and hypertension. Increasing prevalence, changing lifestyle and progression of the disease without obvious symptoms had led to increasing morbidity and mortality. The non-infectious epidemic of the century is posing great challenges to healthcare and research in development of more infrastructure and funds to prevent and treat the disease. MATERIALS AND METHODS A total of 100 patients diagnosed with CAD and posted for Coronary Angiogram (CAG in ICCU at KIMS Hospital, Hubballi, were studied over a period of one and a half year. Cases were categorised according to ATPIII and new IDF criteria for metabolic syndrome and compared. Clinical evaluation, ECG, lipid profile and 2D-echo was done. Statistical analysis done using unpaired t-test, Mann-Whitney tests, Chi-square test and Kappa statistics. RESULTS Of the total 100, 57 had metabolic syndrome by either ATP criteria or IDF criteria. Kappa=0.859 (p-value 150 mg/dL and DM or FBS >100 mg/dL (p value <0.001. The mean values of SBP (144.0 vs. 120.8, DBP (85.6 vs. 73.8 and waist circumference (95.4 vs. 87.7 was statistically significant (p value <0.01 between patients with metabolic syndrome and without metabolic syndrome with IDF criteria (p value <0.001. It was observed LAD (28.1% was the most common vessel involved individually. There was no much significance related to metabolic syndrome. Incidence of CAD was more common in patients with metabolic syndrome than other group. CONCLUSION The prevalence of metabolic syndrome was high in patients with CAD. Both metabolic syndrome definitions identify subset

  17. Report on visit from Prof. Kim Lutzen: Friday, 6 November 1998, Korolinska Institute (dept of nursing Stockholm, Sweden

    Directory of Open Access Journals (Sweden)

    Kim Lutzen

    1999-10-01

    Full Text Available Prof. Kim Lutzen contacted the Department of Advanced Nursing Sciences, Unisa, via the Department's Web Page. Prof. Lutzen is the Chair of the Department of Nursing, which offers undergraduate, master and doctoral programmes. This Department of Nursing is situated within the Karolinska Institute, which comprises 29 Departments of Health Sciences, including a number of Medical Departments, Dentistry, Occupational Therapy, Physiotherapy, and Nursing. Prof. Lutzen emphasised that there is no Swedish phrase similar to "nursing science", consequently this t e n seems to be somewhat unfamiliar to the Swedish nurses. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  18. The complete larval development of Eurypanopeus canalensis Abele and Kim, 1989 (Crustacea: Brachyura: Panopeidae described from laboratory reared material

    Directory of Open Access Journals (Sweden)

    Marcelo U. García-Guerrero

    2005-09-01

    Full Text Available The estuarine panopeid crab Eurypanopeus canalensis Abele and Kim, 1989, is an eastern tropical Pacific species with a known distribution from the southeastern Gulf of California, Mexico, to Panama. Its complete larval development is fully described and illustrated from laboratory-reared material. The four zoeal stages and the megalopa are compared with two congeneric species from the West Atlantic, E. abbreviatus (Stimpson, 1860 and E. depressus (Smith, 1869. The main differences between larvae of E. canalensis and those of these two species include telson setation and the presence/absence of a stout hook-like spine in the megalopae cheliped ischium.

  19. An Inquiry of Intentions in Kim Hye-yong's 'First Meeting': A North Korean Short Story in Korea Today (2007).

    OpenAIRE

    Alzo David-West

    2013-01-01

    This paper examines the problem of the intentional fallacy in the North Korean short story 'First Meeting' by Kim Hye-yong. Serially published in Korea Today in 2007, the nationalist allegory centres on Shin Ch'ong-mi, a young female journalist in Pyongyang, who falls in love with her penfriend Song-u, a soldier in the Korean People's Army, and struggles to remain devoted to him when he suddenly stops writing. With the literary-critical method of counterintuitive reading, the inquiry analyses...

  20. Teasing out the compressed education debates in contemporary South Korea: Media portrayal of figure skater Yuna Kim

    OpenAIRE

    Kim, Hye Jin

    2013-01-01

    In this thesis, I argue that the heated debates about South Korea’s education policy consist of problems that arise from different genres of discourses that in turn belong to different historical moments and education values. I engage in a media discourse analysis of the reportage on South Korean international sport celebrity Yuna Kim that highlight the key education debates currently taking place in South Korea. First, I deal with the neologism umchinttal (my mom’s friend’s daughter) as an i...

  1. The Expression of the Femininity and Imperialism : Through comparison study of works of Toshiko Tamura and Myung-soon Kim

    OpenAIRE

    金, 玟妵

    2005-01-01

    Toshiko Tamura and Myung-soon Kim flourished in 1910-20 in Japan and Korea. In those days it was an act of a man to write. The feminine was demanded above all to the thing which a woman wrote by the literary world and the society, so that woman does not invade a domain of a man. A lot of studies about that the motherhood is one of a model of feminine, it was used to mobilize a woman for war, while militarism advances. Then is what kind of position was there the femininity at socially and cult...

  2. New Nordic Exceptionalism: Jeuno JE Kim and Ewa Einhorn's The United Nations of Norden and other realist utopias

    Directory of Open Access Journals (Sweden)

    Mathias Danbolt

    2016-11-01

    Full Text Available At the 2009 Nordic Culture Forum summit in Berlin that centered on the profiling and branding of the Nordic region in a globalized world, one presenter stood out from the crowd. The lobbyist Annika Sigurdardottir delivered a speech that called for the establishment of “The United Nations of Norden”: A Nordic union that would gather the nations and restore Norden's role as the “moral superpower of the world.” Sigurdardottir's presentation generated such a heated debate that the organizers had to intervene and reveal that the speech was a performance made by the artists Jeuno JE Kim and Ewa Einhorn. This article takes Kim and Einhorn's intervention as a starting point for a critical discussion of the history and politics of Nordic image-building. The article suggests that the reason Kim and Einhorn's speech passed as a serious proposal was due to its meticulous mimicking of two discursive formations that have been central to the debates on the branding of Nordicity over the last decades: on the one hand, the discourse of “Nordic exceptionalism,” that since the 1960s has been central to the promotion of a Nordic political, socio-economic, and internationalist “third way” model, and, on the other hand, the discourse on the “New Nordic,” that emerged out of the New Nordic Food-movement in the early 2000s, and which has given art and culture a privileged role in the international re-fashioning of the Nordic brand. Through an analysis of Kim and Einhorn's United Nations of Norden (UNN-performance, the article examines the historical development and ideological underpinnings of the image of Nordic unity at play in the discourses of Nordic exceptionalism and the New Nordic. By focusing on how the UNN-project puts pressure on the role of utopian imaginaries in the construction of Nordic self-images, the article describes the emergence of a discursive framework of New Nordic Exceptionalism.

  3. Validation Study of Kim's Sham Needle by Measuring Facial Temperature: An N-of-1 Randomized Double-Blind Placebo-Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Sanghun Lee

    2012-01-01

    Full Text Available Introduction. In 2008, Kim's sham needle was developed to improve the quality of double-blinded studies. The aim of this study is to validate Kim's sham needle by measuring facial temperature. Methods. We designed “N-of-1” trials involving 7 smokers. One session was composed of 2 stimulations separated by a 2 h washout period. Six sessions were applied daily for all subjects. Infrared thermal imaging was used to examine the effects of acupuncture (HT8, KI2 on facial temperature following smoking-induced decrease. Results. All subjects demonstrated decreased temperatures after sham needle treatment, but 5 of the 7 subjects showed increased temperatures after real needle treatment. 6 of the 7 subjects showed a significant difference (P<0.05 between treatments with real and sham needles. Thus, the physiological stimulation of Kim's sham needle is different from that of a real needle, suggesting that Kim's sham needle is a potential inactive control intervention.

  4. Muusikauudised : Lu : k ja Jäääär koos laval. Britney Spears tegutseb. Lenny Kravitz ja Mick Jagger. Kim Wilde

    Index Scriptorium Estoniae

    2001-01-01

    Tartus Sõbra majas toimunud kontserdist. Videost "Britney: The video". Heliplaatidest: "Britney", "The Best of Pink Floyd", "Lenny", Mick Jagger "Goddess In The Doorway", "The Very Best Of Kim Wilde"

  5. Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

    Science.gov (United States)

    Nozaki, Yuji; Nikolic-Paterson, David J; Snelgrove, Sarah L; Akiba, Hisaya; Yagita, Hideo; Holdsworth, Stephen R; Kitching, A Richard

    2012-05-01

    The T-cell immunoglobulin mucin 1 (Tim-1) modulates CD4(+) T-cell responses and is also expressed by damaged proximal tubules in the kidney where it is known as kidney injury molecule-1 (Kim-1). We sought to define the role of endogenous Tim-1 in experimental T-cell-mediated glomerulonephritis induced by sheep anti-mouse glomerular basement membrane globulin acting as a planted foreign antigen. Tim-1 is expressed by infiltrating activated CD4(+) cells in this model, and we studied the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) on immune responses and glomerular disease. Crescentic glomerulonephritis, proliferative injury, and leukocyte accumulation were attenuated following treatment with anti-Tim-1 antibodies, but interstitial foxp3(+) cell accumulation and interleukin-10 mRNA were increased. T-cell proliferation and apoptosis decreased in the immune system along with a selective reduction in Th1 and Th17 cellular responses both in the immune system and within the kidney. The urinary excretion and renal expression of Kim-1 was reduced by anti-Tim-1 antibodies reflecting diminished interstitial injury. The effects of anti-Tim-1 antibodies were not apparent in the early phase of renal injury, when the immune response to sheep globulin was developing. Thus, endogenous Tim-1 promotes Th1 and Th17 nephritogenic immune responses and its neutralization reduces renal injury while limiting inflammation in cell-mediated glomerulonephritis.

  6. Viscous flux flow velocity and stress distribution in the Kim model of a long rectangular slab superconductor

    Science.gov (United States)

    Yang, Yong; Chai, Xueguang

    2018-05-01

    When a bulk superconductor endures the magnetization process, enormous mechanical stresses are imposed on the bulk, which often leads to cracking. In the present work, we aim to resolve the viscous flux flow velocity υ 0/w, i.e. υ 0 (because w is a constant) and the stress distribution in a long rectangular slab superconductor for the decreasing external magnetic field (B a ) after zero-field cooling (ZFC) and field cooling (FC) using the Kim model and viscous flux flow equation simultaneously. The viscous flux flow velocity υ 0/w and the magnetic field B* at which the body forces point away in all of the slab volumes during B a reduction, are determined by both B a and the decreasing rate (db a /dt) of the external magnetic field normalized by the full penetration field B p . In previous studies, υ 0/w obtained by the Bean model with viscous flux flow is only determined by db a /dt, and the field B* that is derived only from the Kim model is a positive constant when the maximum external magnetic field is chosen. This means that the findings in this paper have more physical contents than the previous results. The field B* stress changing with decreasing field B a after ZFC if B* ≤ 0. The effect of db a /dt on the stress is significant in the cases of both ZFC and FC.

  7. Helen Kim as New Woman and Collaborator: A Comprehensive Assessment of Korean Collaboration under Japanese Colonial Rule

    Directory of Open Access Journals (Sweden)

    AhRan Ellie Bae

    2017-02-01

    Full Text Available Although almost seventy years has passed since Korea's liberation from Japanese rule, the issue of collaboration still haunts Korea today. Attempts to resolve this issue have tended to focus attention on the traitorous actions of "collaborators" without considering the gray areas that surround their actions such as the circumstances that influenced the accused to commit their alleged traitorous acts and the intentions that drove their decisions. Helen Kim, as a "new woman" and an educator, valued the necessity of providing education for women. Yet, her efforts to realize this goal, to the contrary, forced her into actions that would later be used to construct a reputation as a Japanese collaborator. Korea's nationalist historiography has a tendency to polarize this issue by categorizing a "collaborator" as either a traitor or a patriot. However, when we take a closer look at these collaborators' lives, we discover that most collaboration happened in gray areas where it is often difficult to clearly draw a line between treason and collaboration. Helen Kim's case suggests that the issue of collaboration cannot be fully explained by nationalist historiography's framework and we must give attention to these gray areas. Through her story I hope to complicate the issue of collaboration by raising questions that address the gray areas that surround the actions of "collaborators." In doing so, I hope to challenge the nationalist historiography's propensity to oversimplify this issue and present a more nuanced understanding of it.

  8. An Inquiry of Intentions in Kim Hye-yong's 'First Meeting': A North Korean Short Story in Korea Today (2007.

    Directory of Open Access Journals (Sweden)

    Alzo David-West

    2013-11-01

    Full Text Available This paper examines the problem of the intentional fallacy in the North Korean short story 'First Meeting' by Kim Hye-yong. Serially published in Korea Today in 2007, the nationalist allegory centres on Shin Ch'ong-mi, a young female journalist in Pyongyang, who falls in love with her penfriend Song-u, a soldier in the Korean People's Army, and struggles to remain devoted to him when he suddenly stops writing. With the literary-critical method of counterintuitive reading, the inquiry analyses the structural relations of the narrative, its discourse on desire, its apparent intentions, and its contravening elements, revealing an incidental unstable narrative that is symbolically protesting of the moral of the story to affectionately embrace the political authority of the North Korean party-army regime in the military-first (songun era.

  9. Cooling Simulation and Thermal Abuse Modeling of Lithium-Ion Batteries Using the Newman, Tiedemann, Gu, and Kim (NTGK) Model

    DEFF Research Database (Denmark)

    Saeed Madani, Seyed; Swierczynski, Maciej Jozef; Kær, Søren Knudsen

    2017-01-01

    This paper gives insight into the cooling simulation and thermal abuse modeling of lithium-ion batteries by ANSYS FLUENT. Cooling strategies are important issues in the thermal management of lithium-ion battery systems, and it is essential to investigate them attentively in order to maintain...... the functioning temperature of batteries within an optimum range. The high temperature is able not only to decrease the efficiency of batteries but also may lead to the thermal runaway. To comprehend further, the thermal abuse behavior of lithium-ion batteries based on The Newman, Tiedemann, Gu, and Kim (NTGK......) model has been implemented in ANSYS FLUENT software. The results show that to achieve an optimum energy consumption for battery cooling, a minimum value of average heat transfer coefficient can be selected in order to keep the functioning temperature of batteries within an optimum range....

  10. Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography.

    Science.gov (United States)

    Torregrosa, Isidro; Montoliu, Carmina; Urios, Amparo; Andrés-Costa, María Jesús; Giménez-Garzó, Carla; Juan, Isabel; Puchades, María Jesús; Blasco, María Luisa; Carratalá, Arturo; Sanjuán, Rafael; Miguel, Alfonso

    2015-11-01

    Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early detection of AKI in these patients, comparing their performance with another group of cardiac surgery patients. Biomarkers were measured in 193 patients, 12 h after intervention. In the ROC analysis, AUC for KIM-1, NGAL and L-FABP was 0.713, 0.958 and 0.642, respectively, in the coronary angiography group, and 0.716, 0.916 and 0.743 in the cardiac surgery group. Urinary KIM-1 12 h after intervention is predictive of AKI in adult patients undergoing coronary angiography, but NGAL shows higher sensitivity and specificity. L-FABP provides inferior discrimination for AKI than KIM-1 or NGAL in contrast to its performance after cardiac surgery. This is the first study showing the predictive capacity of KIM-1 for AKI after coronary angiography. Further studies are still needed to answer relevant questions about the clinical utility of biomarkers for AKI in different clinical settings.

  11. Procjena citomorfologije, HPV statusa i HPV 16 genotipa u predikciji ishoda bolesti kod pacijentica s citološkim nalazom ASCUS i LSIL

    OpenAIRE

    Vrdoljak-Mozetič, Danijela; Štemberger-Papić, Snježana; Verša Ostojić, Damjana; Rubeša-Mihaljević, Roberta; Dinter, Morana; Brnčić-Fischer, Alemka; Krašević, Maja

    2016-01-01

    Cilj: Istražiti međusobnu povezanost i prognostički značaj HPV statusa (humani papiloma-virus), HPV 16 genotipa i citomorfologije kod pacijentica s citološkim nalazom abnormalnih stanica pločastog epitela vrata maternice graničnog i blagog stupnja. Materijali i metode: U studiju su uključene pacijentice s inicijalnim citološkim nalazom vrata maternice atipičnih skvamoznih stanica neodređenog značenja (ASCUS, N = 160) i skvamozne intraepitelne lezije niskog stupnja (LSIL, N = 155). Analizirane...

  12. KIM, Steady-State Transport for Fixed Source in 2-D Thermal Reactor by Monte-Carlo

    International Nuclear Information System (INIS)

    Cupini, E.; De Matteis, A.; Simonini, R.

    1980-01-01

    1 - Description of problem or function: KIM (K-infinite Monte Carlo) is a program which solves the steady-state linear transport equation for a fixed-source problem (or, by successive fixed-source runs, for the eigenvalue problem) in a two-dimensional infinite thermal reactor lattice. The main quantities computed in some broad energy groups are the following: - Fluxes and cross sections averaged over the region (i.e. a space portion that can be unconnected but contains everywhere the same homogeneous material), grouping of regions, the whole element. - Average absorption and fission rates per nuclide. - Average flux, absorption and production distributions versus energy. 2 - Method of solution: Monte Carlo simulation is used by tracing particle histories from fission birth down through the resonance region until absorption in the thermal range. The program is organised in three sections for fast, epithermal and thermal simulation, respectively; each section implements a particular model for both numerical techniques and cross section representation (energy groups in the fast section, groups or resonance parameters in the epithermal section, points in the thermal section). During slowing down (energy above 1 eV) nuclei are considered as stationary, with the exception of some resonance nuclei whose spacing between resonances is much greater than the resonance width. The Doppler broadening of s-wave resonances of these nuclides is taken into account by computing cross sections at the current neutron energy and at the temperature of the nucleus hit. During thermalization (energy below 1 eV) the thermal motion of some nuclides is also considered, by exploiting scattering kernels provided by the library for light water, heavy water and oxygen at several temperatures. KIM includes splitting and Russian roulette. A characteristic feature of the program is its approach to the lattice geometry. In fact, besides the usual continuous treatment of the geometry using the well

  13. Kim Magrini | NREL

    Science.gov (United States)

    System Control software Education Ph.D., Physical Chemistry, University of Colorado at Boulder, 1984-1989 But Converges During Decomposition-Transformation," Soil Biology and Biochemistry (2013) " Catalytic Conditioning of Biomass-Derived Syngas," Topics in Catalysis (2012) "Transformation of

  14. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time

    NARCIS (Netherlands)

    Kramer, Andrea B.; van Timmeren, Mirjan M.; Schuurs, Theo A.; Vaidya, Vishal S.; Bonventre, Joseph V.; van Goor, Harry; Navis, Gerjan

    Kramer AB, van Timmeren MM, Schuurs TA, Vaidya VS, Bonventre JV, van Goor H, Navis G. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time. Am J Physiol Renal Physiol 296: F1136-F1145, 2009. First published February

  15. Evaluation of a commercially available ELISA kit for quantifying imidacloprid residues in Erthrina sandwicensis leaves for management of the Erythrina gall wasp, Quadrastichus erythrinae Kim.

    Science.gov (United States)

    Joseph Fischer; Brian Strom; Sheri Smith

    2009-01-01

    The erythrina gall wasp (EGW), Quadrastichus erythrinae Kim 2004, was first detected in Hawaii in 2005 and has been infesting and killing Erythrina trees throughout the island chain since. It is believed EGW originated from Africa (Messing et al. 2009). Its host range appears to be limited to Erythrina; its...

  16. The trouble with halos: invited commentary on Kim, S., & Harris, P. L. (2014). Children prefer to learn from mind-readers. British Journal of Developmental Psychology.

    Science.gov (United States)

    Richert, Rebekah A

    2014-11-01

    This commentary on Kim and Harris (2014) addresses the authors' interpretation of the halo effect, in which 5- to 6-year-old children preferentially agreed with an informant who could read other people's minds, regardless of domain of knowledge. © 2014 The British Psychological Society.

  17. Understanding internal backgrounds in NaI(Tl) crystals toward a 200 kg array for the KIMS-NaI experiment

    Energy Technology Data Exchange (ETDEWEB)

    Adhikari, P.; Adhikari, G.; Oh, S.Y. [Sejong University, Department of Physics, Seoul (Korea, Republic of); Choi, S.; Joo, H.W.; Kim, K.W.; Kim, S.K. [Seoul National University, Department of Physics and Astronomy, Seoul (Korea, Republic of); Ha, C.; Jeon, E.J.; Kang, W.G.; Kim, H.O.; Kim, N.Y.; Lee, H.S.; Lee, J.H.; Lee, M.H.; Leonard, D.S.; Li, J.; Olsen, S.L.; Park, H.K.; Park, K.S.; So, J.H.; Yoon, Y.S. [Institute for Basic Science, Center for Underground Physics, Daejeon (Korea, Republic of); Hahn, I.S. [Ewha Womans University, Department of Science Education, Seoul (Korea, Republic of); Kim, H.J. [Kyungpook National University, Department of Physics, Daegu (Korea, Republic of); Kim, Y.D. [Sejong University, Department of Physics, Seoul (Korea, Republic of); Institute for Basic Science, Center for Underground Physics, Daejeon (Korea, Republic of); Kim, Y.H. [Institute for Basic Science, Center for Underground Physics, Daejeon (Korea, Republic of); Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of); Park, H.S. [Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of)

    2016-04-15

    The Korea Invisible Mass Search (KIMS) collaboration has developed low-background NaI(Tl) crystals that are suitable for the direct detection of WIMP dark matter. Building on experience accumulated during the KIMS-CsI programs, the KIMS-NaI experiment will consist of a 200 kg NaI(Tl) crystal array surrounded by layers of shielding structures and will be operated at the Yangyang underground laboratory. The goal is to provide an unambiguous test of the DAMA/LIBRA annual modulation signature. Measurements of six prototype crystals show progress in the reduction of internal contamination from radioisotopes. Based on our understanding of these measurements, we expect to achieve a background level in the final detector configuration that is less than 1 count/day/keV/kg for recoil energies around 2 keV. The annual modulation sensitivity for the KIMS-NaI experiment shows that an unambiguous 7σ test of the DAMA/LIBRA signature would be possible with a 600 kg year exposure with this system. (orig.)

  18. Anthropocene Knowledge Practices in McKenzie Wark’s Molecular Red and Kim Stanley Robinson’s Aurora

    Directory of Open Access Journals (Sweden)

    Gib Prettyman

    2018-02-01

    Full Text Available Through a close reading of McKenzie Wark’s theoretical treatise 'Molecular Red' (2015 and Kim Stanley Robinson’s novel 'Aurora' (2015, this essay examines how Anthropocene knowledge practices challenge our conceptions of human agency in provocative and potentially productive ways. For example, our knowledge of climate science arises through global material infrastructures. As material components of Anthropocene knowledge practices, these infrastructures reveal the material labors and cyborg structures by means of which our knowledge is produced. Wark sees the heterogenous materiality of Anthropocene knowledge practices as evidence for the value of ‘low theories’ based on a ‘labor point of view.’ At the same time, Anthropocene knowledge practices reveal ‘eco-logical’ complexities and fundamental recognitions of the ‘intra-action’ of entangled matter. These complexities produce very estranged views of human agency. Robinson’s novel highlights the eco-logical implications of contemporary knowledge practices by imagining an interstellar ship that must function as a completely artificial ecosystem for a 170-year voyage to another solar system. The significance of knowledge practices and eco-logical complexity is most evident when failures or crises arise, and 'Aurora' tells the story of many such failures. However, I argue that Robinson’s novel and Wark’s ‘low theory’ ultimately function as hopeful accounts of Anthropocene knowledge practices. Among other things, these practices show the material importance of storytelling and point the way toward more complexly realist theories of human agency.

  19. Concept development of "compassion fatigue" in clinical nurses: Application of Schwartz-Barcott and Kim's hybrid model

    Directory of Open Access Journals (Sweden)

    Mahdieh Sabery

    2017-06-01

    Full Text Available Compassion fatigue is not a new concept in nursing; yet, it is not well known and there is no fixed clear definition of the term. The ambiguity surrounding how to define compassion fatigue has challenged its measurement and evaluation. Thus, any attempt to determine attributes of this underdeveloped concept and studying it in a new socio-cultural context requires concept development. The purpose of this study is to clarify the concept of compassion fatigue through concept development and to produce a vivid and tentative definition of this concept in clinical practice. Concept development was conducted using a three-step hybrid concept analysis including theoretical, fieldwork, and final analysis phases according to Schwartz-Barcott and Kim's method. We reviewed and analyzed 48 articles that met the inclusion criteria. Following, the first author conducted 13 interviews with clinical nurses followed by an inductive content analysis. Finally, a comprehensive definition of compassion fatigue in nurses was attained. Compassion fatigue in nurses can be explained as a cumulative and progressive process of absorption of the patient’s pain and suffering formed from the sympathetic and caring interactions with the patients and their families. The physical, emotional, intellectual, spiritual, social, and organizational consequences of compassion fatigue are so extensive that they threaten the existential integrity of the nurse. Context-based variables (culture, family, and community such as personality features like devotion behaviors and commitment towards the patient, exposure to multiple stressors, organizational challenges, and lack of self-care are factors associated with an increased risk of compassion fatigue. Concept development of compassion fatigue is the first step in the protection of nurses against the destructive consequences of compassion fatigue and to improve quality of care.

  20. Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka.

    Science.gov (United States)

    De Silva, Pallagae Mangala C S; Mohammed Abdul, Khaja Shameem; Eakanayake, Eakanayake M D V; Jayasinghe, Sudheera Sammanthi; Jayasumana, Channa; Asanthi, Hewa Bandulage; Perera, Hettiarachigae S D; Chaminda, Gamage G Tushara; Chandana, Ediriweera P S; Siribaddana, Sisira H

    2016-09-01

    Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734) were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence) and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1) and Bandagiriya (EL2). Albuminuria (ACR ≥ 30mg/g); serum creatinine based estimation of glomerular filtration rate (eGFR); creatinine normalized urinary kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were measured. Fourteen new CKDu cases (18%) from EL1 and nine CKDu cases (9%) from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr). No CKDu cases were identified in non-endemic study locations in Matara (CM) and Nuwara Eliya (CN). Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal injury

  1. Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka

    Science.gov (United States)

    Mohammed Abdul, Khaja Shameem; Eakanayake, Eakanayake M. D. V.; Jayasinghe, Sudheera Sammanthi; Jayasumana, Channa; Asanthi, Hewa Bandulage; Perera, Hettiarachigae S. D.; Chaminda, Gamage G. Tushara; Chandana, Ediriweera P. S.; Siribaddana, Sisira H.

    2016-01-01

    Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734) were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence) and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1) and Bandagiriya (EL2). Albuminuria (ACR ≥ 30mg/g); serum creatinine based estimation of glomerular filtration rate (eGFR); creatinine normalized urinary kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were measured. Fourteen new CKDu cases (18%) from EL1 and nine CKDu cases (9%) from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr). No CKDu cases were identified in non-endemic study locations in Matara (CM) and Nuwara Eliya (CN). Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal injury

  2. Can You Anchor a Shimmering Nation State via Regional Indigenous Roots? Kim Scott talks to Anne Brewster about That Deadman Dance

    Directory of Open Access Journals (Sweden)

    Anne Brewster

    2011-10-01

    Full Text Available This interview focuses mainly on Kim Scott’s new novel That Deadman Dance which won the regional Commonwealth Writers Prize (Southeast Asian and Pacific region and the Miles Franklin Award. The topics of conversation include Scott’s involvement in the Noongar language project (and the relationship of this project to the novel, the novel itself, the challenges of writing in English, the resistance paradigm and indigenous sovereignty and nationalism.

  3. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus.

    Science.gov (United States)

    Fufaa, Gudeta D; Weil, E Jennifer; Nelson, Robert G; Hanson, Robert L; Bonventre, Joseph V; Sabbisetti, Venkata; Waikar, Sushrut S; Mifflin, Theodore E; Zhang, Xiaoming; Xie, Dawei; Hsu, Chi-Yuan; Feldman, Harold I; Coresh, Josef; Vasan, Ramachandran S; Kimmel, Paul L; Liu, Kathleen D

    2015-01-01

    Kidney injury molecule 1 (KIM-1), liver fatty acid-binding protein (L-FABP), N-acetyl-β-D-glucosaminidase (NAG) and neutrophil gelatinase-associated lipocalin (NGAL) are urinary biomarkers of renal tubular injury. We examined their association with incident end-stage renal disease (ESRD) and all-cause mortality in American Indians with type 2 diabetes. Biomarker concentrations were measured in baseline urine samples in 260 Pima Indians who were followed for a median of 14 years. HRs were reported per SD of creatinine (Cr)-normalised log-transformed KIM-1, NAG and NGAL, and for three categories of L-FABP. During follow-up, 74 participants developed ESRD and 101 died. Median concentrations of KIM-1/Cr, NAG/Cr and NGAL/Cr and the proportion of detectable L-FABP were highest in those with macroalbuminuria (p associated with ESRD (HR 1.59, 95% CI 1.20, 2.11) and mortality (HR 1.39, 95% CI 1.06, 1.82); L-FABP/Cr was inversely associated with ESRD (HR [for highest vs lowest tertile] 0.40, 95% CI 0.19, 0.83). Addition of NGAL/Cr to models that included albuminuria and glomerular filtration rate increased the c-statistic for predicting ESRD from 0.828 to 0.833 (p = 0.001) and for death from 0.710 to 0.722 (p = 0.018). Addition of L-FABP/Cr increased the c-statistic for ESRD from 0.828 to 0.832 (p = 0.042). In Pima Indians with type 2 diabetes, urinary concentrations of NGAL and L-FABP are associated with important health outcomes, but they are unlikely to add to risk prediction with standard markers in a clinically meaningful way given the small increase in the c-statistic.

  4. Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu among Agricultural Communities in Sri Lanka.

    Directory of Open Access Journals (Sweden)

    Pallagae Mangala C S De Silva

    2016-09-01

    Full Text Available Chronic Kidney Disease of uncertain etiology (CKDu is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734 were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1 and Bandagiriya (EL2. Albuminuria (ACR ≥ 30mg/g; serum creatinine based estimation of glomerular filtration rate (eGFR; creatinine normalized urinary kidney injury molecule (KIM-1 and neutrophil gelatinase-associated lipocalin (NGAL were measured. Fourteen new CKDu cases (18% from EL1 and nine CKDu cases (9% from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr. No CKDu cases were identified in non-endemic study locations in Matara (CM and Nuwara Eliya (CN. Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal

  5. „Ritualno” i „struktuirano” odbacivanje u arheološkim interpretacijama: primer sistema za vodosnabdevanje na lokalitetu „Kale” u Krševici

    Directory of Open Access Journals (Sweden)

    Ivan Vranić

    2016-11-01

    Full Text Available Pitanja vezana za rituale, kultove, religiju ili magiju predstavljaju važne ali u značajnoj meri zanemarene i teorijski nedovoljno precizno utemeljene teme u savremenim arheološkim interpretacijama. Cilj rada jeste da na konkretnim primerima potencijalno ritualnih aktivnosti vezanih za izgradnju i moguće „ritualno ubijanje” sistema za vodosnabdevanje na lokalitetu „Kale” u Krševici pokaže kako ovo zanemarivanje nije samo posledica aktuelnosti i trendova o odabiru istraživačkih tema, već se radi o ozbiljnijem problemu koji pokazuje određene nedostatke savremenih pristupa vezanih za arheologiju identiteta i koncepte struktuiranog ili simboličkog odbacivanja.

  6. The prevalence of musculoskeletal disorders and occupational risk factors in Kashan SAIPA automobile industry workers by key indicator method (KIM, 1390

    Directory of Open Access Journals (Sweden)

    2012-05-01

    Full Text Available Introduction: work related musculoskeletal disorders are the most wide spread type of occupational diseases among workers. Awkward body postures during work and manual material handling are among the most important risk factors of musculoskeletal disorders in different jobs. Due to importance of recognizing these factors prevalence and risk factor of work related musculoskeletal disorders, this research was aimed to study the among employees of Kashan City’s Saipa automobile industry in 2011. .Material and Method: This study is a descriptive-cross sectional study conducted among workers with manual material handling 37 activities and 84 work duties. To recognize musculoskeletal disorders, body map questionnaire was applied and occupational risk factors were evaluated using Key Index Method (KIM. Data was analyzed using SPSS and Excel software. .Result: Highest prevalence of musculoskeletal disorders was in low and upper back region (%92. Based on the results from KIM, workers in the installing the tire, shuttle-aided fitting of seat, and engine work station had higher risk level with the scores of 66, 52 and 52, respectively. Risk level among three individuals (%3.6 was at 1, 40 (%47.6 at 2, 38 (%45.2 risk level 3, and 3 (%3.6 at 4. .Conclusion: Awkward body posture, improper twisting and flexion of low back were major risk factor among worker doing manual material handling tasks. Regarding the high prevalence of musculoskeletal disorders, appropriate ergonomic interventions such as engineering and organization interactions can reduce this risk factors (posture, heavy load, duration, workplace conditions as much as the risk level reach to an acceptable level.

  7. "The Day All of the Different Parts of Me Can Come Along": Intersectionality and U.S. Third World Feminism in the Poetry of Pat Parker and Willyce Kim.

    Science.gov (United States)

    Van Ausdall, Mimi Iimuro

    2015-01-01

    This article brings to light the poetry of Pat Parker and Willyce Kim, two key figures within the 1970s and '80s women in print movement. While Parker and Kim have been rightly placed within African-American and Asian-American histories, respectively, and working-class and lesbian-feminist literary histories, their work is most fully understood within the context of U.S. Third World Feminism. Through close readings of poetic form and content in addition to engagement with current debates about intersectionality as a methodology, the article links Kim and Parker's works to central contributions of U.S. Third World Feminism such as intersectionality and power across and within difference that continue to influence feminist theory today.

  8. Soo soomlaste südames ja soo lugudes / Piret Paal

    Index Scriptorium Estoniae

    Paal, Piret, 1977-

    2011-01-01

    Tutvustus: Laurén, Kirsi. Suo - sisulla ja sydämellä : suomalaisten suokokemukset ja -kertomukset kulttuurisen luontosuhteen ilmentäjinä. Helsinki : Suomalaisen Kirjallisuuden Seura, 2006 (doktoritöö)

  9. Analysis of the coexisting pathways for NO and N2O formation in Chernozem using the (15)N-tracer SimKIM-Advanced model.

    Science.gov (United States)

    Stange, Claus Florian; Spott, Oliver; Russow, Rolf

    2013-01-01

    The nitrogen (N) cycle consists of a variety of microbial processes. These processes often occur simultaneously in soils, but respond differently to local environmental conditions due to process-specific biochemical restrictions (e.g. oxygen levels). Hence, soil nitrogen cycling (e.g. soil N gas production through nitrification and denitrification) is individually affected through these processes, resulting in the complex and highly dynamic behaviour of total soil N turnover. The development and application of methods that facilitate the quantification of individual contributions of coexisting processes is a fundamental prerequisite for (i) understanding the dynamics of soil N turnover and (ii) implementing these processes in ecosystem models. To explain the unexpected results of the triplet tracer experiment (TTE) of Russow et al. (Role of nitrite and nitric oxide in the processes of nitrification and denitrification in soil: results from (15)N tracer experiments. Soil Biol Biochem. 2009;41:785-795) the existing SimKIM model was extended to the SimKIM-Advanced model through the addition of three separate nitrite subpools associated with ammonia oxidation, oxidation of organic nitrogen (Norg), and denitrification, respectively. For the TTE, individual treatments with (15)N ammonium, (15)N nitrate, and (15)N nitrite were conducted under oxic, hypoxic, and anoxic conditions, respectively, to clarify the role of nitric oxide as a denitrification intermediate during N2O formation. Using a split nitrite pool, this analysis model explains the observed differences in the (15)N enrichments in nitric oxide (NO) and nitrous oxide (N2O) which occurred in dependence on different oxygen concentrations. The change from oxic over hypoxic to anoxic conditions only marginally increased the NO and N2O release rates (1.3-fold). The analysis using the model revealed that, under oxic and hypoxic conditions, Norg-based N2O production was the dominant pathway, contributing to 90 and 50

  10. Urinary Vitamin D Binding Protein and KIM-1 Are Potent New Biomarkers of Major Adverse Renal Events in Patients Undergoing Coronary Angiography.

    Directory of Open Access Journals (Sweden)

    Lyubov Chaykovska

    Full Text Available Vitamin-D-binding protein (VDBP is a low molecular weight protein that is filtered through the glomerulus as a 25-(OH vitamin D 3/VDBP complex. In the normal kidney VDBP is reabsorbed and catabolized by proximal tubule epithelial cells reducing the urinary excretion to trace amounts. Acute tubular injury is expected to result in urinary VDBP loss. The purpose of our study was to explore the potential role of urinary VDBP as a biomarker of an acute renal damage.We included 314 patients with diabetes mellitus or mild renal impairment undergoing coronary angiography and collected blood and urine before and 24 hours after the CM application. Patients were followed for 90 days for the composite endpoint major adverse renal events (MARE: need for dialysis, doubling of serum creatinine after 90 days, unplanned emergency rehospitalization or death.Increased urine VDBP concentration 24 hours after contrast media exposure was predictive for dialysis need (no dialysis: 113.06 ± 299.61 ng/ml, n = 303; need for dialysis: 613.07 ± 700.45 ng/ml, n = 11, Mean ± SD, p<0.001, death (no death during follow-up: 121.41 ± 324.45 ng/ml, n = 306; death during follow-up: 522.01 ± 521.86 ng/ml, n = 8; Mean ± SD, p<0.003 and MARE (no MARE: 112.08 ± 302.00 ng/ml, n = 298; MARE: 506.16 ± 624.61 ng/ml, n = 16, Mean ± SD, p<0.001 during the follow-up of 90 days after contrast media exposure. Correction of urine VDBP concentrations for creatinine excretion confirmed its predictive value and was consistent with increased levels of urinary Kidney Injury Molecule-1 (KIM-1 and baseline plasma creatinine in patients with above mentioned complications. The impact of urinary VDBP and KIM-1 on MARE was independent of known CIN risk factors such as anemia, preexisting renal failure, preexisting heart failure, and diabetes.Urinary VDBP is a promising novel biomarker of major contrast induced nephropathy-associated events 90 days after contrast media exposure.

  11. Kim Davis: A Mother's Dilemma.

    Science.gov (United States)

    Hudecki, Michael S.

    2000-01-01

    Presents a discussion case in which parents must decide whether or not to enroll their sons in an experimental treatment program for muscular dystrophy. Identifies teaching objectives and discusses the key issues of the case--muscle structure and function, muscular dystrophy, scientists and money, scientific method and the FDA, and family health…

  12. Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine.

    Science.gov (United States)

    Zhang, Jun; Goering, Peter L; Espandiari, Parvaneh; Shaw, Martin; Bonventre, Joseph V; Vaidya, Vishal S; Brown, Ronald P; Keenan, Joe; Kilty, Cormac G; Sadrieh, Nakissa; Hanig, Joseph P

    2009-08-01

    The present study compared the immunolocalization of Kim-1, renal papillary antigen (RPA)-1, and RPA-2 with that of inducible nitric oxide synthase (iNOS) and nitrotyrosine in kidneys of gentamicin sulfate (Gen)- and cisplatin (Cis)-treated rats. The specificity of acute kidney injury (AKI) biomarkers, iNOS, and nitrotyrosine was evaluated by dosing rats with valproic acid (VPA). Sprague-Dawley (SD) rats were injected subcutaneously (sc) with 100 mg/kg/day of Gen for six or fourteen days; a single intraperitoneal (ip) dose of 1, 3, or 6 mg/kg of Cis; or 650 mg/kg/day of VPA (ip) for four days. In Gen-treated rats, Kim-1 was expressed in the epithelial cells, mainly in the S1/S2 segments but less so in the S3 segment, and RPA-1 was increased in the epithelial cells of collecting ducts (CD) in the cortex. Spatial expression of iNOS or nitrotyrosine with Kim-1 or RPA-1 was detected. In Cis-treated rats, Kim-1 was expressed only in the S3 segment cells, and RPA-1 and RPA-2 were increased in the epithelial cells of medullary CD or medullary loop of Henle (LH), respectively. Spatial expression of iNOS or nitrotyrosine with RPA-1 or RPA-2 was also identified. These findings suggest that peroxynitrite formation may be involved in the pathogenesis of Gen and Cis nephrotoxicity and that Kim-1, RPA-1, and RPA-2 have the potential to serve as site-specific biomarkers for Gen or Cis AKI.

  13. Standards of Justice for Human Being and Doing in Kim Stanley Robinson’s 2312 and C. S. Friedman’s This Alien Shore

    Directory of Open Access Journals (Sweden)

    Claire P. Curtis

    2017-09-01

    Full Text Available The creation of superior societies and communities in which bodies live better and thrive depends on richly detailed accounts of imagined societies including flexible theories of justice that can be used to evaluate them. Both Kim Stanley Robinson’s '2312' (2012 and C. S. Friedman’s 'This Alien Shore' (1998 attempt to rethink what bodies can do and be, by exploring ways of living together among those with different, and differently compatible, bodies. The novels are set in future spacefaring societies away from the Earth, which nevertheless struggle with the fact of Earth’s existence. Each novel describes radical cognitive and bodily change: chosen alteration in '2312' and environmental transformation in 'This Alien Shore'. In each novel, the body, and what bodies can do and be, is a central issue. But how might we evaluate the societies these novels describe to gauge their contributions to articulating desires for a better way of being? In this article I employ Martha Nussbaum’s ‘capabilities approach’ (encompassing life, bodily health, bodily integrity, senses, emotions, reason, affiliation, play, other species, control over environment to think about justice in the articulation of evaluative standards. In so doing the analysis I develop addresses some key questions raised by these novels, including: Whose body will matter? Will there be bodily norms? How will communities confront different bodily abilities? How can we enhance our own thinking about how to live in and among bodies? How does (and should the idea of the body politic change when our expectations about bodies changes?

  14. Supplementary data: Association of CTLA4, CD28 and ICOS gene ...

    Indian Academy of Sciences (India)

    Supplementary data: Association of CTLA4, CD28 and ICOS gene polymorphisms with clinicopathologic characteristics of childhood IgA nephropathy in Korean population. Hak-Jae Kim, Joo-Ho Chung, Sungwook Kang, Su-Kang Kim, Byoung-Soo Cho, Sung-Do Kim and Won-Ho Hahn. J. Genet. 90, 151–155. Table 1.

  15. Gevalle van positiewe taalbeplanning soos gerapporteer in die ...

    African Journals Online (AJOL)

    Southern African Linguistics and Applied Language Studies ... Conversely, however, cases of positive language planning in respect of the languages ... generally and enthusiastically treated as part of a general policy, it would not have been ...

  16. 'n Godsleer van Openbaring soos vervat in die himnes

    Directory of Open Access Journals (Sweden)

    E. Meyer

    1997-07-01

    Full Text Available A Theology of Revelations as imbedded in the hymns. This anicle is based on a twofold hypothesis, namely that the author of Revelation not only wrote the hymns in this book,' he also used them specifically to express his theology. The narrator utilises the hymnes to lay words in the mouths of the characters in order to establish a complete theology as well as christology. These hymns can even be used today to offer mankind real hope by calling one and all to the centre and true reason for our existence: Worship God!

  17. Kuidas tagada efektiivne riigi õigusabi kriminaalmenetluses? / Anneli Soo

    Index Scriptorium Estoniae

    Soo, Anneli, 1984-

    2014-01-01

    Riigi vastutusest efektiivse kaitse õiguse rikkumise korral. Kohtulikust järelevalvest kaitsjate tegevuse üle kriminaalmenetluses. Efektiivse süsteemi väljatöötamisest riigi õigusabi andmiseks

  18. High frequency plant regeneration from mature seed- derived callus ...

    African Journals Online (AJOL)

    PRECIOUS

    2009-12-15

    Dec 15, 2009 ... Ki-Won Lee, Gi Jun Choi, Ki-Yong Kim, Hee Chung Ji, Hyung Soo Park, Sei Hyung Yoon and ... Gramineae family plants (Ha et al., 2001; Dong and Qu, ..... Lee SH, Ahsan N, Lee KW, Kim DH, Lee DG, Kwak SS, Kwon SY, ...

  19. Baseline characteristics and response to 2 years of growth hormone (GH) replacement of hypopituitary patients with GH deficiency due to adult-onset craniopharyngioma in comparison with patients with nonfunctioning pituitary adenoma: data from KIMS (Pfizer International Metabolic Database).

    Science.gov (United States)

    Verhelst, Johan; Kendall-Taylor, Pat; Erfurth, Eva Marie; Price, David Anthony; Geffner, Mitchell; Koltowska-Häggström, Maria; Jönsson, Peter J; Wilton, Patrick; Abs, Roger

    2005-08-01

    In epidemiological studies, hypopituitary adults show increased mortality compared with population controls. Patients with hypopituitarism caused by a craniopharyngioma (CP) and/or its treatment have a higher mortality than patients with other etiologies, such as a nonfunctioning pituitary adenoma (NFPA). To analyze this difference, we used the KIMS database (Pfizer International Metabolic Database) comparing CP and NFPA patients in terms of baseline characteristics and responses to GH replacement. Baseline characteristics were studied in 351 CP patients (189 men and 162 women; mean age, 42.5 yr) and compared with 370 NFPA patients, matched for age and sex (185 men and 185 women; mean age, 42.5 yr). The effects of 2 yr of GH replacement were analyzed in a subgroup of 183 CP and 209 NFPA patients. At baseline, both CP and NFPA patients had characteristic features of GH deficiency, with low serum IGF-I, increased body fat, dyslipidemia, and reduced quality of life. Male CP patients were significantly more obese (30.0 vs. 28.2 kg/m2; P = 0.0003) compared with NFPA patients, had a higher waist/hip ratio (P = 0.004), higher triglycerides (P = 0.003), and lower high-density lipoprotein cholesterol (P = 0.03). Similar, but much smaller, differences were seen in female CP compared with NFPA patients, only reaching significance for waist/hip ratio (P = 0.05) and triglycerides (P = 0.0004). CP patients had more often undergone surgery by the transcranial route (68.8% vs. 30.9%; P NFPA patients (58.7% vs. 19.8%; P NFPA patients. After 2 yr of GH replacement therapy, similar significant improvements were evident in both groups in fat-free mass, total and low-density lipoprotein cholesterol, and Quality-of-Life-Assessment in GH Deficient Adults score compared with baseline. In contrast to NFPA patients, CP patients had no significant decrease in body fat with GH therapy. In the KIMS database, patients with CP have more often undergone surgery by the transcranial route than

  20. Retarderi na teškim vozilima

    Directory of Open Access Journals (Sweden)

    Joško Rapanić

    2012-10-01

    Full Text Available The objective of all the braking systems fitted in vehicles isto reduce the speed, as well as to keep them at a standstill. Inorder to increase the active road traffic safety, the experts inthe leading vehicle manufacturer companies are trying from day to day to find a more efficient solution of the highest possiblequality. Braking problems, i.e. problems of stopping the vehiclesare closely related to time, forces, momentum, mass andother physical quantities. This is best seen in the braking ofheavy duty vehicles, trucks, buses, where the braking efficacyis questionable due to high inertia forces caused by heavyweight and more recently relatively high speeds. Such vehiclesare fitted with system of brakes that operate on compressed airor combination of pneumatics and hydraulics, since the driverhas not got enough power to achieve appropriate braking effect.However, the biggest problems occur by trucks runningdownhill, when the braking system is operated continuously fora longer period of time. This causes heating and overheating ofthe system elements ("fading", thus reducing the braking effect.In extreme cases, particularly if the system is poorly maintained,it can eventually fail completely.Because of the mentioned reasons for difficulties in brakingof trucks, such vehicles have been recently fitted with anauxiliary slow-down system. This system is completely independentfromthe main one on the wheels and is used exclusivelyfor slowing down or for maintaining of speed.

  1. Ajateenistusest, ausalt! / Kim Järvepõld

    Index Scriptorium Estoniae

    Järvepõld, Kim

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 9. apr. 2007, lk. 7. Autor leiab, et põhiseaduslik nõue, mille järgi on kõik Eesti kodanikud kohustatud osa võtma riigikaitsest, pole vastavuses tegeliku olukorraga, ning arvab, et kohustuslik ajateenistus tuleb kaotada või viia kooskõlla põhiseadusega

  2. kim Tasarım ve Ekşi Sözlük: İnternet’in Dönüşümünü Anlamak

    Directory of Open Access Journals (Sweden)

    Babacan Taşdemir

    2014-02-01

    Full Text Available Son yıllarda bir yanda devletler, diğer yanda sermaye kuruluşları, siyasi, idari ve ticari amaçları ile İnternet ortamını gittikçe daha fazla kolonileştirmektedirler. Bu da siyasi ve ticari baskılardan azade bir özgürlük alanı olarak görülen İnternet’e ilişkin toplumsal beklentilere zıt bir durum ortaya çıkarmaktadır. Çalışmamız, İnternet’teki bu dönüşümü üretim gücü ve üretim ilişkileri kavramları üzerinden eleştirel bir gözle değerlendirmeyi önermektedir. Dönüşüm, ‘Teknolojik Değişimin Döngüsel Modeli’ndeki ‘mayalanma dönemi’ ve ‘hâkim tasarım’ kavramlarının sunduğu potansiyelden faydalanılarak açıklanmaya çalışılmaktadır.  Burada ‘mayalanma dönemi’ ile İnternette ifade özgürlüğü açısından daha uygun olan ilk dönemlere, ‘hâkim tasarım’ ile ise yerleşik üretim ve iktidar ilişkilerinin daha fazla nüfuz ettiği yakın döneme gönderme yapılmaktadır. Ekşi Sözlük örneği ile de savlarını destekleyen çalışmamız, üç kategori üzerinden örnek olaylarla Sözlük’ün dönüşümünü değerlendirmektedir: İş çevreleriyle ticari ilişkilere bağlı dönüşüm, İnternet’in düzenlenmesine dair hukuki çerçeve ve kamu otoriteleri ile ilişkilere bağlı olarak geçirilen dönüşüm, Sözlük kullanıcıları ve sahipleri arasındaki örgütsel ilişkinin değişimi dolayımında geçirilen dönüşüm. Sonuç olarak, İnternet’in ‘mayalanma döneminde’, yani görece serbest bir ortamda, Ekşi Sözlük popülaritesini ve saygınlığını, yaratıcı ve muhalif duruş ile karakterize olan bir ifade alanı olarak kazansa da, zaman içinde tamamen kâr merkezli bir işletmeye dönüşmektedir. Böylece bir yandan pazarlama stratejilerinin ana mecralarından biri diğer yandan da politik baskıya tabii sıradan bir forum ve paylaşım sitesi haline gelmektedir. Sözlük’ün gelişimine ilişkin örnek olaylar ele

  3. Kim, czym, kiedy, gdzie i dlaczego są polscy Żydzi? Wyobrażanie, konstruowanie i zawłaszczanie Żydów polskich

    Directory of Open Access Journals (Sweden)

    Scott Ury

    2017-12-01

    Full Text Available Who, what, when, where, and why is Polish Jewry? Envisioning, constructing, and possessing Polish Jewry This article examines the different ways that various communities of scholars imagine, research and teach about “Polish Jewry.” Focusing on scholarship written in Israel, Poland and the United States over the past generation or two, the article argues that each particular community of scholars constructs a particular version of Polish Jewry and that each of these versions is deeply influenced by contemporary social, political and communal needs and demands. As a result, scholars very often end up constructing radically different versions of Polish Jewish history and society. These scholarly differences reflect many of the challenges and difficulties related to researching and writing about the history and culture of Polish Jews since 1989.   Kim, czym, kiedy, gdzie i dlaczego są polscy Żydzi? Wyobrażanie, konstruowanie i zawłaszczanie Żydów polskich Artykuł stanowi omówienie odmiennych sposobów, jakimi różne społeczności badaczy wyobrażają grupę polskich Żydów, badają ją i nauczają o niej. Na podstawie analizy działalności naukowej badaczy z Izraela, Polski i Stanów Zjednoczonych ostatnich dwóch pokoleń autor pokazuje, że każda społeczność badaczy konstruuje własny, specyficzny obraz grupy zwanej „polskimi Żydami” i że obrazy te pozostają pod przemożnym wpływem współczesnych potrzeb i wymogów o naturze społecznej, politycznej i wspólnotowej. Na skutek tych różnic uczeni tworzą często radykalnie odmienne obrazy historii i społeczeństwa polskich Żydów. Różnice stanowią odzwierciedlenie przeszkód i utrudnień, jakie po 1989 roku wiążą się z badaniem i opisywaniem historii i kultury polskich Żydów.

  4. Keeping Kim; How the Kim Conundrum Best Serves American Interests in the Asia Pacific

    Science.gov (United States)

    2018-04-18

    Bombs South Korea’s Yeonpyeong Island," The Telegraph, November 23. 2010. http://www.telegraph.co.uk/news/worldnews/asia...southkorea/8153000/North-Korea- bombs -South-Koreas- Yeonpyeong-Island.html (accessed 01/05/2017, 2017). 25 A key initiative during the Sunshine Policy was...tr ad in g pa rt ne r Sa m e et hn ic ity ; di ff er en t sy st em o f go ve rn an ce So ve re ig nt y iss ue s a lw ay s co ns id er ed

  5. El individuo en el cambio: la transformación de las relaciones bilaterales entre la República de Corea y la República Popular Democrática de Corea, bajo la figura del presidente surcoreano Kim Dae-Jung

    OpenAIRE

    Perilla Moreno, Jairo Andrés

    2017-01-01

    Este artículo busca interpretar el proceso mediante el cual las ideas y presupuestos políticos y sociales del expresidente surcoreano Kim Dae-Jung, permitieron una transformación significativa de las relaciones bilaterales entre Corea del Sur y Corea del Norte, durante su periodo presidencial entre los años 1998 y 2003. Inicialmente, dichas relaciones estuvieron caracterizadas por una incesante tensión militar como resultado de la Guerra de Corea, escenario dentro del cual apareció la figura ...

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Eul-Won Hwang1 Kyung-A Kim1 Soo-Chul Park2 Mi-Jeong Jeong2 Myung-Ok Byun2 Hawk-Bin Kwon1. Division of Applied Biological Sciences, Sunmoon University, Asan, 336-708, Korea; Abiotic and Biotic Stress Team, National Institute of Agricultural Biotechnology, Suwon 441-707, Korea ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 32; Issue 4. Molecular cloning and expression of the C-terminus of spider flagelliform silk protein from Araneus ventricosus. Kwang Sik Lee Bo Yeon Kim Yeon Ho Je Soo Dong Woo Hung Dae Sohn Byung Rae Jin. Articles Volume 32 Issue 4 June 2007 pp 705-712 ...

  8. Growth characteristics and productivity of cold-tolerant “Kowinearly ...

    African Journals Online (AJOL)

    Growth characteristics and productivity of cold-tolerant “Kowinearly” Italian ryegrass in the northern part of South Korea. Gi Jun Choi, Hee Chung Ji, Ki-Yong Kim, Hyung Soo Park, Sung Seo, Ki-Won Lee, Sang-Hoon Lee ...

  9. kim Seyyid Mehmed And His Book Called Nazire-i Hilye-i Hâkanî / HÂKİM SEYYİD MEHMED EFENDİ’NİN “NAZİRE-İ HİLYE-İ HÂKANΔ ADLI ESERİ

    Directory of Open Access Journals (Sweden)

    Yakup POYRAZ (M.A.H.

    2007-08-01

    Full Text Available As a result of the deep divine love people had for our Prophet, various literarytypes such as mevlit and na’t appeared. Of these types, hilye is one of the morepopular ones. Hilyes describe our Prophet physically and morally and theyusually convey the divine love poets have for him. The best-known hilye inTurkish literature, Hilye-i Hâkanî, was written by Hâkanî Mehmet Bey in 16thcentury. One of the nazires written in this hilye belongs to Hâkim SeyyidMehmed who was an 8th century poet. This nazire is usually regarded as one ofthe best in Hilye-i Hâkanî. In this article investigated Hilye-i Hâkanî and madeuseful form to literature.

  10. Pidamata jäänud kõne / Imre Sooäär

    Index Scriptorium Estoniae

    Sooäär, Imre, 1969-

    2007-01-01

    Ilmunud ka: Lääne Elu, 10. apr. 2007, lk. 2; Hiiu Leht, 10. apr. 2007, lk. 2; Põhjarannik, 10. apr. 2007, lk. 2; Severnoje Poberezhje, 10. apr. 2007, lk. 2; Harjumaa, 10. apr. 2007, lk. 2; Virumaa Teataja, 12. apr. 2007, lk. 11; Nädaline, 12. apr. 2007, lk. 2; Sakala, 13. apr. 2007, lk. 2; Harju Ekspress, 13. apr. 2007, lk. 6; Vali Uudised, 13. apr. 2007, lk. 2; Järva Teataja, 14. apr. 2007, lk. 2; Vooremaa, 14. apr. 2007, lk. 2. Parlamendiliige leiab, et Ene Ergma oli parim Riigikogu XI koosseisu kandidaat spiikri kohale

  11. Die “kerklike gesag” van kerkvergaderings soos in die kerkorde van die Nederduitse Gereformeerde Kerk

    Directory of Open Access Journals (Sweden)

    P. J. Strauss

    2008-07-01

      This means that ecclesiastical authority is founded and based on the Word of God by which it sumultaneously is limited. In exercising it’s authority, an assembly is also bound to do it in accordance with the character of the church. To speak of authority in the church is not in conflict with the character of the church as a community of believers connected by love.

  12. 77 FR 66912 - Soo Line Railroad Company-Abandonment Exemption-in Cook County, IL

    Science.gov (United States)

    2012-11-07

    ... governmental agencies) have been met. As a condition to this exemption, any employee adversely affected by the... condition adequately protects affected employees, a petition for partial revocation under 49 U.S.C. 10502(d..., if any, of the abandonment on the environment and historic resources. OEA will issue an environmental...

  13. Kotkaklubi müttas soomlaste kurge otsides Venemaal soos / Marko Püüa

    Index Scriptorium Estoniae

    Püüa, Marko

    2007-01-01

    Vt. Postimees : na russkom jazõke 20. apr., lk. 11. Eesti kotkaklubi liikmed ajasid Venemaal sookure Suhmura jälgi. Soomes Karjala põhjaosas sündinud noor isaslind sai mullu augustis endale selga GPS-saatja, mis andis satelliidi kaudu viimase signaali Pihkva ja Novgorodi oblasti piiri lähedalt

  14. Die selfverstaan van die Samaritane soos dit uit- drukking vind in die feesliturgie צלות מוצד השמיני

    Directory of Open Access Journals (Sweden)

    J. Beyers

    1999-12-01

    Full Text Available The self-understanding of the Samaritans, as expressed in the liturgy of the צלות מוצד השמיני festival This study is concerned with the identity and religion of the Samaritans. The way in which the Samaritans understood their identity is highlighted by their perception of God, by the traditions they adhered to and by the selection of texts from the Pentateuch they used in their liturgy. The beliefs and rituals of the Samarium faith found their way into the Samaritan Liturgy. The study of a part of the Samaritan Liturgy shows that the Samaritans are heirs to the religion of the northern tibes of Israel.

  15. Misdaad in die Suid-Afrikaanse onderwys soos weerspieël in die ...

    African Journals Online (AJOL)

    Erna Kinsey

    gebruikers via die Internet beskikbaar (http://www.samedia.uovs.ac.za). ...... From newspaper reports one can deduce that a culture of crime and violence prevails in South African ..... Vandals trash Mitchell's Plain primary school. Cape Argus, 3.

  16. 30 CFR 250.175 - When may the Regional Supervisor grant an SOO?

    Science.gov (United States)

    2010-07-01

    ... salt sheet; (ii) That all or a portion of a potential hydrocarbon-bearing formation may lie beneath or adjacent to the salt sheet; and (iii) The salt sheet interferes with identification of the potential hydrocarbon-bearing formation. (3) The interpreted geophysical information required under paragraph (b)(2) of...

  17. Eesti õpetajate roll laste internetikasutuse sotsiaalses vahendamises / Kadri Soo, Veronika Kalmus, Mare Ainsaar

    Index Scriptorium Estoniae

    Soo, Kadri

    2015-01-01

    Artiklis käsitletakse õpetajate rolli laste ettevalmistamisel internetimaailma ohtudega toimetulekuks ning analüüsitakse Eesti õpetajate tegevust 9-16aastaste laste internetikasutuse sotsiaalses vahendamises

  18. Urmas Kruuse: ma ei häbene öelda, et olen õnnelik / Kadi Soo

    Index Scriptorium Estoniae

    Soo, Kadi

    2007-01-01

    Ilmunud ka: Linnaleht : Pärnu, 21. dets. 2007, lk. 7-8; Linnaleht : Tartu, 21. dets. 2007, lk. 9-10. Tartu linnapea Urmas Kruuse perekonnast, tööst ja muusika- ja spordihuvist. Lisa: Curriculum vitae

  19. RAZLIKE U MOTORIČKIM SPOSOBNOSTIMA BOKSERA I NESPORTISTA

    Directory of Open Access Journals (Sweden)

    Benin Murić

    2011-03-01

    Full Text Available This research was conducted with the aim to define differences in motor abilities and morphological characteristics between judists and non/athletes of the same age. Sample encompassed 120 subjects having 60 students non/athletes and 60 students actively engaged in sports. For the evaluation of motor abilities there were conducted 12 measuring instruments. Testing of the posted hypotheses was performed on the basis of statistical data. The obtained results of this research in motor area have shown that there is statistically significant difference between selected boxsers and students not going in for box. This difference is defined by significantly better values and results in motor tests performed by the selected boxers.

  20. Belarus - a unique case in the European context? / Kim Lausten

    Index Scriptorium Estoniae

    Lausten, Kim

    2003-01-01

    Valgevene presidendi Aleksander Lukashenko autoritaarsest režiimist, sellega seonduvatest võimalikest ohtudest Valgevene naaberriikide julgeolekule. Autor analüüsib Lukashenko režiimi institutsioonilisi ning sotsiaalpoliitilisi tagamaid

  1. [Recent books on international law] / Yoonie Kim, Paul R Williams

    Index Scriptorium Estoniae

    Kim, Yoonie

    2005-01-01

    Arvustus: Lauri Mälksoo. Illegal Annexation and State Continuity : The Case of the Incorporation of the Baltic States by the USSR. Study of the Tension between Normativity and Power in International Law. Leiden ; Boston, 2003

  2. Safety assessment of silica and zinc oxide nanoparticles

    OpenAIRE

    An, Seong Soo A; Kim, Meyoung-Kon

    2014-01-01

    Seong Soo A An,1 Meyoung-Kon Kim2 1Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, Gyeonggi, Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, KoreaThe current volume is a special issue focusing on a safety assessment of nanoparticles, from their physicochemical properties to government regulations. It features twenty-five papers, discussing general issues with the possible harmfulness...

  3. Karistusseadustiku § 119¹ ehk tõenduslike probleemide ületamine materiaalõiguse abil / Anneli Soo, Birgit Sisask

    Index Scriptorium Estoniae

    Soo, Anneli, 1984-

    2015-01-01

    1. jaanuaril 2015 jõustus karistusseadustikus rida muudatusi, sh lisandus § 119¹, mis käsitleb kakluses osalemist. Karistusõiguslikest ja põhiseaduslikest põhimõtetest, millega § 119¹ läheb vastuollu

  4. Die doel, taak en terrein van die opvoedkunde soos beoefen aan die PU vir CHO (1935-1985

    Directory of Open Access Journals (Sweden)

    J. L. van der Walt

    1986-03-01

    Full Text Available In agreement with the method of historical weight it was hypothesized that the academic leaders of a Faculty of Education (i.e . the five deans who served in the PU for CHE's Faculty of Education in the period 1935-1985 can be regarded as the tuning fork regarding the aims of the science of education practised in that particular Faculty. The Faculty of Education of the PU for CHE celebrated a half-century of academic work in 1985. This article reports on an analysis of the views of the five deans who served (the last one is still serving in the Faculty, on the aims and the task of the science of education. It was found that interalia one ideal was kept alive by all the deans: to practise education in a Scriptural/Christian way. Also, they all tried to either explain how Scriptural education (Pedagogics works or what efforts should be con­ trived to ensure this form of scientific work. It was also found that certain developments in the views on the roles of norms and facts in the process of scientific work took place as the years went by and greater in sigh t was gained in the philosophy of (educational science.

  5. The role of relA and spoT in Yersinia pestis KIM5 pathogenicity.

    Directory of Open Access Journals (Sweden)

    Wei Sun

    2009-08-01

    Full Text Available The ppGpp molecule is part of a highly conserved regulatory system for mediating the growth response to various environmental conditions. This mechanism may represent a common strategy whereby pathogens such as Yersinia pestis, the causative agent of plague, regulate the virulence gene programs required for invasion, survival and persistence within host cells to match the capacity for growth. The products of the relA and spoT genes carry out ppGpp synthesis. To investigate the role of ppGpp on growth, protein synthesis, gene expression and virulence, we constructed a Delta relA Delta spoT Y. pestis mutant. The mutant was no longer able to synthesize ppGpp in response to amino acid or carbon starvation, as expected. We also found that it exhibited several novel phenotypes, including a reduced growth rate and autoaggregation at 26 degrees C. In addition, there was a reduction in the level of secretion of key virulence proteins and the mutant was > 1,000-fold less virulent than its wild-type parent strain. Mice vaccinated subcutaneously (s.c. with 2.5x10(4 CFU of the Delta relA Delta spoT mutant developed high anti-Y. pestis serum IgG titers, were completely protected against s.c. challenge with 1.5x10(5 CFU of virulent Y. pestis and partially protected (60% survival against pulmonary challenge with 2.0x10(4 CFU of virulent Y. pestis. Our results indicate that ppGpp represents an important virulence determinant in Y. pestis and the Delta relA Delta spoT mutant strain is a promising vaccine candidate to provide protection against plague.

  6. Concept Development of “Nursing Presence”: Application of Schwartz-Barcott and Kim's Hybrid Model

    Directory of Open Access Journals (Sweden)

    Fatemeh Mohammadipour, PhD

    2017-03-01

    Conclusion: Co-constructed interaction underscored the value of the nursing presence as an integral component of caring with humanistic and patient-centered approaches. The findings could help clinical nurses have a better understanding of the nursing presence. Findings also can improve educators' and managers' knowledge for developing and conducting appropriate education strategies and caring activities to facilitate the promotion of nursing presence.

  7. Hlapivi spojevi arome dalmatinske pancete proizvedene u različitim tehnološkim uvjetima

    OpenAIRE

    Krvavica, Marina; Milak, Vedrana

    2017-01-01

    Cilj ovog istraživanja bio je utvrditi u kojoj mjeri razlike u načinu soljenja (sa ili bez aditiva, utrošak soli/salamure, duljina faze soljenja), načinu dimljenja (ložište unutar ili izvan objekta i temperatura dima) te duljina sušenja i zrenja, utječu na sastav hlapivih spojeva arome dalmatinske pancete. U navedenu svrhu uzeta su po 2 uzorka dalmatinske pancete iz dva različita preradbena objekta na području Dalmacije, u kojima je panceta proizvedena na sljedeći način: objekt A – salamurenj...

  8. RAZLIKE U MOTORIČKIM SPOSOBNOSTIMA ODBOJKAŠA I NETRENIRANIH UČENIKA

    Directory of Open Access Journals (Sweden)

    Petar Karadžić

    2011-09-01

    Full Text Available Volleyball is a typical sport of polistructural motion. It is abundant in fast and varied body motions such as jumping, half-roll, rolling and throwing with fast reactions to various situations. This study was conducted with the aim of determining the difference between general motor skills of young volleyball players and untrained boys of the same age. The sample of examinees for this survey was taken from the population of boys aged 15 and 16 years. The experimental group was comprised of 16 male players from VC “Buducnost PB”.. The control group was comprised of 15 eighth grade boys from elementary school "Vuk Karadzic" from Podgorica. Testing of motor abilities in this study was conducted using the following variables: japan test, sargent’s test, standing long jump, throwing a medicine ball from lying position, raising the trunk from the ground, push-ups on the ground, hand taping, and a deep bend on the bench. From the area of comparative parametric statistics, for independent samples, T-test was applied. It was found that between the two groups (trained young volleyball players and their untrained peers in the control group, generally, there is no significant statistical difference in terms of basic motor skills. Statistically significant difference was found only in the test of raising the trunk from the ground which was used to hypothetically evaluate the repetitive potential of abdominal muscles. Only in this test, namely, the realized level of significance was below the theoretical limit (Sig. <.05.. We can assume that volleyball training has an abundance of stimulus that aim on development of abdominal muscles

  9. A Grand Challenge: Immortal Information and Through-Life Knowledge Management (KIM

    Directory of Open Access Journals (Sweden)

    Alexander Ball

    2006-11-01

    Full Text Available ‘Immortal information and through-life knowledge management: strategies and tools for the emerging product-service business paradigm’, is a Grand Challenge project involving eleven different UK universities and incorporating substantial industry collaboration. It is investigating a range of issues associated with the move towards a product-service paradigm in the engineering sector, in particular the long-term curation of digital data, learning from production and use, and appropriate governance and management techniques.

  10. Matematika u vojnotehničkim dostignućima / Mathematics in military-technical achievements

    Directory of Open Access Journals (Sweden)

    Natalija B. Jelenković

    2010-10-01

    Full Text Available Matematika se definiše kao vrsta filozofije ili pogleda na svet, sredstvo za razvijanje apstraktnog mišljenja, a služi i za pojednostavljenje prirodnih nauka. Prilično je specijalna - izučava količinu i poredak; uopšteno, to je nauka o formalnim strukturama. Ona je i kombinacija slobode kreativne misli i strogih logičkih pravila, ali i deduktivna nauka koja daje pravila i zakone pomoću kojih baratamo brojevima i prostorom. Kao takva, matematika je i savremeni alat za vojnotehnička dostignuća modernog doba, kao što su: sve vrste radio i radio-relejnih veza, radarska sredstva, sredstva za upravljanje, navigaciju, televizijska, optoelektronska, hidro- akustična sredstva, sredstva za protivelektronsku borbu, kao i mnoga elektronska tehnička sredstava, naoružanje i vojna oprema Kopnene vojske, Vazduhoplovstva i protiv-vazduhoplovne odbrane, Ratne mornarice. Prethodno istaknute definicije matematike su korišćene kao osnova za uopšteno sistematizovano izlaganje metodom uporednog opisivanja, nabrajanjem činjenica, definisanjem pojmova. Cilj članka je da se na osnovu nabrojanja postojećih primena matematike i proširivanjem znanja može dalje napredovati u istraživanju mnogih vojnih oblasti. Pored toga, članak ima i pedagoški cilj, a to je da kroz opise i karakteristike sredstava ratne tehnike zainteresuje i afirmiše značaj i lepotu vojnog poziva. Rezultati razvoja informacionih tehnologija su, pored ostalog, i savršenija vojnotehnička dostignuća, a predstavljaju i inspiraciju za mnoge inovacije i uspehe. / In this article, mathematics is dealt with as a science necessary for the design, development and implementation of certain military-technical achievements such as many electronic devices, smart missiles, miniature antennas, camouflage military clothing and other military equipment. Some areas of applied, discrete and continuous mathematics are underlined in particular. Application of mathematics The importance of mathematics for military-technical achievements is reflected in the fact that mathematics allowed the existence and development of military disciplines such as: fortifications, military statistics, military economics, cryptography, military psychology, air force, military-technical and military information science. There are also many applications using mathematical models and linear programming. Mathematics is thus necessary and indispensable as a tool, a way of expression and communication, as well as the basic creation of further progress. This article reveals the connection of mathematics and certain military areas that are important for the development of the armed forces and war materiel. The application of mathematics in military- technical achievements is entailed in the connection of mathematics with military disciplines. Information technology - Basic concepts Some identified problems occurring in military purposes are mentioned through some basic concepts and benefits related to information technology. Comparative description and listing of characteristic traits resulting in the noticed and given advantages and disadvantages highlighted the creation of information technologies, first by using conventional programs and programming and then by using artificial intelligence and expert systems.

  11. Systemically applied insecticides for treatment of erythrina gall wasp, quadrastichus erythrinae kim hymenoptera: Eulophidae

    Science.gov (United States)

    Doccola, J.J.; Smith, S.L.; Strom, B.L.; Medeiros, A.C.; Von Allmen, E.

    2009-01-01

    Abstract The erythrina gall wasp (EGW), believed native to Africa, is a recently described species and now serious invasive pest of Erythrina (coral trees) in tropical and subtropical locales. Erythrina are favored ornamental and landscape trees, as well as native members of threatened ecosystems. The EGW is a tiny, highly mobile, highly invasive wasp that deforms (galls) host trees causing severe defoliation and tree death. The first detection of EGW in the United States was in O'ahu, Hawai'i in April 2005. It quickly spread through the Hawai'ian island chain (U.S.) killing ornamental and native Erythrina in as little as two years. At risk are endemic populations of Erythrinaas well as ornamental landscape species in the same genus, the latter of which have already been killed and removed from O'ahu at a cost of more than USD $1 million. Because EGW are so small and spread so quickly, host injury is usually detected before adult wasps are observed, making prophylactic treatments less likely than therapeutic ones. This study evaluates two stem-injected insecticides, imidacloprid (IMA-jet??) and emamectin benzoate, delivered through Arborjet Tree I.V.?? equipment, for their ability to affect E. sandwicensis (wiliwili) canopy demise under severe EGW exposure. IMA-jet, applied at a rate of 0.16 g AI/cm basal diameter (0.4 g AI/in. dia.), was the only effective treatment for maintaining canopy condition of wiliwili trees. Emamectin benzoate, applied at a rate of -0.1 g AI/cm basal diameter (-0.25 g AI/in. dia.), was not effective in this application, although it was intermediate in effect between IMA-jet and untreated trees. The relatively high concentrations of imidacloprid in leaves, and its durability for at least 13 months in native wiliwili growing on a natural, dryland site, suggest that treatment applications against EGW can impact canopy recovery even under suboptimal site and tree conditions. ?? 2009 International Society of Arboriculture.

  12. RAZLIKE U MOTORIČKIM SPOSOBNOSTIMA UČENIKA SPORTISTA I UČENIKA NESPORTISTA

    Directory of Open Access Journals (Sweden)

    Hasim Mekić

    2011-09-01

    Full Text Available Teaching physical education in primary schools takes more character to growing concerns that stem from the personal attitude of the students teaching on the one hand, and poor motivation of teachers due to lack of adequate working conditions for the other. As the official attitude of the community not to allow such a situation, the more we meet with the appearance of lack of justification to continue the spread of pronunciation, and very little to takemeasures to combat such a situation. Testing in sport and physical education, at the present time is the present phenomenon than it was before. Course planned test involves measuring the organized team sports, students in specialized conditions (laboratories. However, testing is a term that includes the daily, routine measurement of results in the function of training process monitoring results as either transverse or longitudinal cross-section of states. Motor skills are one of the psychosomatic status, which expresses the efficiency of motor response and motor behavior of humans. Motor skills are very important part during the building of sports performance in most sports. One part of the motor abilities under significant influence of genetic factors, while the other part subject to the influence of various external factors, especially in sports exercise which is represented in physical education and sports training for children and youth, sports and recreation for adults.

  13. Primena GIS-a u hidrološkim istraživanjima - primer reke Lepenice

    Directory of Open Access Journals (Sweden)

    Milanović Ana

    2007-01-01

    Full Text Available The basic component of GIS technology (Geographical Information Systems is the base of graphical data, which can be used for geographical definition of spaces elements- entities. As a new, modern, technology, it has more application in different hydrological researches. In GIS creation Lepenica river basin, it was applied softwares: Micro Station, GeoMedia, Surfer 7. Map and AutoCAD. After data base creation, it was enabled for users to get different information of Lepenica river basin on the simple way. Getting data are used for creation of three thematic maps (altitude zones map, hydrographical net map and precipitation isoline map.

  14. Dr Jung Hyun KIM Vice Minister for Education, Science and Technology MEST Republic of Korea

    CERN Multimedia

    Jean-Claude Gadmer

    2010-01-01

    He learnt about CERN's LHC computing grid project from Frédéric Hemmer, head of the information technology department. In addition, the vice-minister toured the ATLAS visitor centre, the CMS control centre, the ALICE experiment's exhibition and control room, and he met Korean scientists at CERN.

  15. Obredi i teologija u mistagoškim katehezama Ćirila Jeruzalemskoga

    OpenAIRE

    Mandac, Marijan

    2002-01-01

    U uvodnom dijelu donosi se kratki životopis sv. Ćirila Jeruzalemskoga i prikaz njegovih Mistagoških kateheza kojima se najavljuje hrvatski prijevod. Potom se predstavlja kratak sadržaj svih pet mistagoških kateheza: Prva s obredima odricanja od Sotone, pristajanje uz Krista i ispovijed vjere; Druga s obredom pomazanja i odijevanja posebne krsne odjeće; Treća je posvećena potvrdi i predstavlja nezaobilazno djelo patrističke literature o tome; Četvrta izlaže otajstvo euharistije, a peta tumači ...

  16. RAZLIKE U MOTORIČKIM SPOSOBNOSTIMA UČENIKA SPORTISTA I UČENIKA NESPORTISTA

    OpenAIRE

    Hasim Mekić; Benin Murić; Vladan Milić; Fahrudin Mavrić

    2011-01-01

    Teaching physical education in primary schools takes more character to growing concerns that stem from the personal attitude of the students teaching on the one hand, and poor motivation of teachers due to lack of adequate working conditions for the other. As the official attitude of the community not to allow such a situation, the more we meet with the appearance of lack of justification to continue the spread of pronunciation, and very little to takemeasures to combat such a situation. Test...

  17. Sinise ookeani strateegia : konkurentsi vältimise kunst / W. Chan Kim, Renee Mauborgne

    Index Scriptorium Estoniae

    Kim, W. Chan, 1952-

    2006-01-01

    Sinise ookeani strateegia õpetab, kuidas tegutseda konkurentidest vabal turul. Kommenteerib Hansapanga juhatuse esimees Erkki Raasuke. Lisad: Sinine ookean Tartus; Punane ookean versus sinine ookean. Tabel: Sinise ookeani loomise ajaloost

  18. North Korea’s Provocation and Escalation Calculus: Dealing with the Kim Jong-un Regime

    Science.gov (United States)

    2015-08-01

    regime. “The Interview” In the early 2000s, Seth Rogan and Evan Goldberg conceived of a plot for a comic take on the assassination of a world...responsible for the education and training of the regime’s cyber warriors.55  The State Security Department’s (secret police) communications monitoring and...is young and lacks the expansive and deep education his father had before taking the reins of power. This has created a certain narrative in the

  19. Lessons learned from 15 years of KIMS and 5 years of ACROSTUDY

    DEFF Research Database (Denmark)

    Luger, Anton; Feldt-Rasmussen, Ulla; Abs, Roger

    2011-01-01

    -deficient adults for 15 years. Approximately 5 years ago, the ACROSTUDY database was established to monitor the long-term safety and effectiveness of pegvisomant in patients with acromegaly. CONCLUSIONS: By collecting data on the treatment of relatively rare conditions in routine clinical practice...

  20. TIP ORGANIZACIJE GRUPE U KOŠARKAŠKIM TIMOVIMA 1. LIGE SRBIJE I CRNE GORE

    Directory of Open Access Journals (Sweden)

    Igor Vučković

    2006-06-01

    Full Text Available In this study were analysed the differences between better placed and worse placed teams of the First basketaball league of Serbia and Montenegro in The type of group organization. The aim was to see in which type of group organization (extrovert or introvert mentioned teams belong, and then to relate it with the final position of their team on the standing. After discriminant analysis it was concluded that there are significant differences between better placed and worse placed teams in The type of group organization with the benefit of the better placed teams.

  1. Type 2-diabetes--en heterogen sygdom med kim i fostertilstanden

    DEFF Research Database (Denmark)

    Vaag, Allan

    2012-01-01

    Type 2 diabetes (T2D) is a heterogeneous disease with a multifactorial aetiology involving defects in the pancreatic beta cells, liver, muscles, adipose tissue, guts, brain, kidneys and heart. While genetics may only explain a minor proportion of T2D, the contribution of an adverse intrauterine...... environment may take centre stage in the global propagation of T2D. Impaired expandability of subcutaneous adipose tissue in persons with low birthweight may cause T2D due to lipotoxicity in non-adipose organs. Future implications include a stronger focus on individualized treatments in T2D patients...

  2. Fluorinated Materials for Air-stable and Moisture-resistant Flexible Optoelectronics

    Science.gov (United States)

    2014-01-02

    Kim Jong , H.; Shin, S.; Yang, H.; An, B.-K.; Yang, L.; Park Soo, Y. Adv Mater 2012, 24, 911-915; (c) Geng, Y.; Li, H.-B.; Wu, S.-X.; Su, Z.-M. J...Park, J.-U.; Shir, D. J.-L.; Nam , Y.-S.; Jeon, S.; Rogers, J. A. Chem. Rev. 2007, 107, 1117-1160; (g) Murphy, A. R.; Frechet, J. M. J. Chem. Rev. 2007...2649-2655; (w) Song, H.-J.; Kim , D.-H.; Lee, E.-J.; Heo, S.-W.; Lee, J.-Y.; Moon, D.-K. Macromolecules (Washington, DC, U. S.) 2012, 45, 7815- 7822; (x

  3. Silica nanoparticle-based dual imaging colloidal hybrids: cancer cell imaging and biodistribution

    Directory of Open Access Journals (Sweden)

    Lee H

    2015-08-01

    Full Text Available Haisung Lee,1 Dongkyung Sung,2 Jinhoon Kim,3 Byung-Tae Kim,3 Tuntun Wang,4 Seong Soo A An,5 Soo-Won Seo,6 Dong Kee Yi4 1Molecular Diagnostics, In Vitro Diagnostics Unit, New Business Division, SK Telecom, 2Department of Life Sciences, Graduate School of Korea University, 3Interdisciplinary Graduate Program of Biomedical Engineering, School of Medicine, Sungkyunkwan University, Samsung Medical Center, 4Department of Chemistry, Myongji University, Seoul, 5Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, 6Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea Abstract: In this study, fluorescent dye-conjugated magnetic resonance (MR imaging agents were investigated in T mode. Gadolinium-conjugated silica nanoparticles were successfully synthesized for both MR imaging and fluorescence diagnostics. Polyamine and polycarboxyl functional groups were modified chemically on the surface of the silica nanoparticles for efficient conjugation of gadolinium ions. The derived gadolinium-conjugated silica nanoparticles were investigated by zeta potential analysis, transmission electron microscopy, inductively coupled plasma mass spectrometry, and energy dispersive x-ray spectroscopy. MR equipment was used to investigate their use as contrast-enhancing agents in T1 mode under a 9.4 T magnetic field. In addition, we tracked the distribution of the gadolinium-conjugated nanoparticles in both lung cancer cells and organs in mice. Keywords: dual bioimaging, MR imaging, silica colloid, T1 contrast imaging, nanohybrid

  4. Enesekaitsesituatsioonides vahetu sunni kasutamine vanglas. Karistusõiguslik ja haldusõiguslik analüüs / Anneli Soo, Kaidi Tarros

    Index Scriptorium Estoniae

    Soo, Anneli, 1984-

    2015-01-01

    Vanglaametniku poolt vahetu sunni kasutamisest enese või teise isiku kaitseks. Vahetu sunni kasutamise nõuetest vangistusõiguses, vanglaamentiku vastutuse välistamise tingimustest karistusseadustiku (KarS) alusel ning distsiplinaarvastutusest ja riigivastutusest. Asjakohasest kohtupraktikast

  5. Ekologiese waarnemings van 'n Bergskilpadpopulasie, Geochelone pardalis Bell, 1828, soos aangeteken in die Soetdoring-Natuurreser-vaat in die Oranje-Vrystaat

    Directory of Open Access Journals (Sweden)

    M. Rall

    1985-12-01

    Full Text Available Hierdie studie poog om vas te stel of die bergskilpad Geochelone pardalis Bell, 1828, habitatsvoorkeure asook territoriale neigings toon. Geen territorialiteit bestaan nie maar wel loopgebiede waarbinne die skilpad meeste van sy aktiwiteite bedryf. Bewegingspatrone van 'n aantal individuele skilpaaie word bespreek. This study ascertains whether the mountain tortoise Geochelone pardalis Bell, 1828, shows habitat preferences and territorial tendencies. No territorialism was found but most activities took place within a certain range. Movement patterns of a number of individual tortoises are described.

  6. Üks kord lõika, üheksa korda mõõda / Imre Sooäär

    Index Scriptorium Estoniae

    Sooäär, Imre, 1969-

    2004-01-01

    Ilmunud ka: Severnoje Poberezhje, 27. märts 2004, lk. 2; Vooremaa, 30. märts 2004, lk. 2; Hiiu Leht, 30. märts 2004, lk. 2; Nädaline, 30. märts 2004, lk. 4; Meie Maa, 30. märts 2004, lk. 2; Pärnu Postimees, 2. apr. 2004, lk. 15; Valgamaalane, 6. apr. 2004, lk. 2. Euroopa ühise põllumajanduspoliitika rakendamise seaduse vastuvõtmisest Riigikogus

  7. Aspekte van die genetiese proses by Opperman soos afgelei uit ’n variantestudie van 'Gedagtes by ’n sarkofaag'

    Directory of Open Access Journals (Sweden)

    E. Meihuizen

    2003-08-01

    Full Text Available Aspects of the genetic process in the poetry of D.J. Opperman based on an analysis of different versions of the poem 'Gedagtes by ’n sarkofaag' (Thoughts on a sarcophagus A study of the genesis of a literary text reveals the systematic changes effected by the author during the creative process, and an understanding of these creative tendencies foregrounds structural principles of the final text. In studying a larger corpus of the author’s work, scrutiny of text development affords the means to gain insight into stylistic, semantic and thematic characteristics of the author’s oeuvre. This article focuses on the genesis of D.J. Opperman’s poem “Gedagtes by ’n sarkofaag” within the theoretical framework of Dutch edition theory as represented by Dorleijn (1984, Mathijsen (1997 and De Bruijn (2000 in particular. The different phases of development in the genesis of “Gedagtes by ’n sarkofaag” are identified and represented in a synoptic apparatus. In the analysis of the textual development particular attention is paid to the creation of a symbolic level.

  8. ʼn Studie van die gesondheid van die Olifantsrivier soos weerspieël deur die makro-invertebraatbiodiversiteit en geselekteerde abiotiese faktore

    Directory of Open Access Journals (Sweden)

    M. Kemp

    2012-03-01

    Full Text Available Riviere in Suid-Afrika is ‘n belangrike waterbron en onderhou ‘n ryk biodiversiteit van fauna en flora. Toenemende druk op hierdie riviere en hulle opvanggebiede kan ʼn enorme impak op die lewe wat hulle onderhou, uitoefen.

  9. Laste seksuaalne väärkohtlemine - selle ennetamise võimalikkusest : [bakalaureusetöö] / Janika Soo ; Õigusinstituut ; juhendaja: Airi Ross

    Index Scriptorium Estoniae

    Soo, Janika

    2002-01-01

    Laste seksuaalse väärkohtlemise olemus, liigid, soodustavad asjaolud, viitavad märgid ja nende äratundmine, laste õigusi kaitsvad organisatsioonid, kehtiv õiguslik regulatsioon, juhtumi analüüs

  10. Tahtluse vormid ning nende eristamine teoorias ja praktikas : [bakalaureusetöö] / Mattias Jõgi ; Tartu Ülikool, õigusteaduskond ; juhendaja: Anneli Soo

    Index Scriptorium Estoniae

    Jõgi, Mattias

    2010-01-01

    Tahtlusest Ameerika Ühendriikides ja mandri-Euroopas, tahtluse vormidest Eestis 1935. a. kriminaalseadustiku ja 1961. a. kriminaalkoodeksi järgi, tahtluse vormide eristamisest ja esinemisest kehtivas karistusseadustikus, kelmusest ja selle erikoosseisudest, kohtuotsustes tahtluse vormide eristamisest

  11. Kuritegeliku ühenduse mõiste : ne bis in idem põhimõte. Riigikohtu kriminaalkolleegiumi otsus asjas 3-1-1-57-09 / Anneli Soo

    Index Scriptorium Estoniae

    Soo, Anneli, 1984-

    2010-01-01

    Riigikohtu otsusest asjas 3-1-1-57-09: N. Kohtovi kaitsja vandeadvokaat Tarmo Pilve kassatsioon Tartu Ringkonnakohtu 18. veebruari 2009. a kohtuotsuse peale kriminaalasi N. Kohtovi süüdistuses KarS § 256 lg 1, § 120 ja § 121 järgi

  12. Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

    Directory of Open Access Journals (Sweden)

    Kim MS

    2016-12-01

    Full Text Available Min Soo Kim,1,* Dong Woo Yeom,1,* Sung Rae Kim,1 Ho Yub Yoon,1 Chang Hyun Kim,1 Ho Yong Son,1 Jin Han Kim,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, South Korea *These authors contributed equally to this work Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS was developed, which consisted of chitosan (CTN based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two-level factorial design method. Drug-release characteristics in terms of dissolution efficiency and controlled-release duration were evaluated in various dissolution media, such as simulated colonic fluid in the presence or absence of CTNase. Microflora activation and a stepwise mechanism for drug release were postulated. Consequently, the optimized DL-CDDS showed drug release in a controlled manner by inhibiting drug release in the stomach and intestine, but releasing the drug gradually in the colon (approximately 40% at 10 hours and 92% at 24 hours in CTNase-supplemented simulated colonic fluid, indicating its feasibility as a novel platform for CDD. Keywords: chitosan, colon-specific delivery, acidification, microflora, factorial design, controlled release

  13. Spotlight on nano-theranostics in South Korea: applications in diagnostics and treatment of diseases

    Directory of Open Access Journals (Sweden)

    Lee S

    2015-08-01

    Full Text Available Sangwha Lee,1,* Jongsung Kim,1,* Chung Wung Bark,2 Bonghee Lee,3 Heongkyu Ju,4 Se Chan Kang,5 TaeYoung Kim,6 Moon Il Kim,6 Young Tag Ko,3 Jeong-Seok Nam,3 Hyon Hee Yoon,1 Kyu-Sik Yun,1,6 Young Soo Yoon,1 Seong Soo A An,1,6 John Hulme6 1BioNano Sensor Research Center, 2Department of Electrical Engineering, Gachon University, Seongnam-si, 3Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 4Department of Nano-Physics, 5Department of Life Science, Gachon University, 6Department of BioNano Technology, Gachon BioNano Research Institute, Seongnam-si, South Korea *These authors contributed equally to this work Abstract: From the synergistic integration and the multidisciplinary strengths of the BioNano Sensor Research Center, Gachon Bionano Research Institute, and Lee GilYa Cancer and Diabetes Institute, researchers, students, and faculties at Gachon University in collaboration with other institutions in Korea, Australia, France, America, and Japan have come together to produce a special issue on the diverse applications of nano-theranostics in nanomedicine. This special issue will showcase new research conducted by various scientific groups in Gyonggi-do and Songdo/Incheon, South Korea. The objectives of this special issue are as follows: 1 to bring together and demonstrate some of the latest research results in the field, 2 to introduce new multifunctional nanomaterials and their applications in imaging and detection methods, and 3 to stimulate collaborative interdisciplinary research at both national and international levels in nanomedicine. Keywords: cancer, imaging and therapeutics, antibacterial, disease, neurodegenerative

  14. Savremene metode analize ulja u tehničkim sistemima / Modern methods of oil analysis in technical systems

    Directory of Open Access Journals (Sweden)

    Sreten R. Perić

    2010-01-01

    Full Text Available Analiza ulja na osnovu pravilno definisanog programa predstavlja veoma efikasan metod monitoringa stanja tehničkih sistema koji obezbeđuje rane upozoravajuće znake potencijalnih problema, koji vode ka otkazu i zastoju tehničkih sistema. Ova analiza je veoma efikasan alat programa za monitoring stanja tehničkih sistema. Mnogobrojni uređaji i testovi za analizu ulja omogućavaju kvalitetan monitoring i dijagnosticiranje problema koji nastaju u procesu podmazivanja. Korišćenjem programa za analizu motornih ulja: skraćuje se neplanirano vreme otkaza vozila, poboljšava pouzdanost vozila, produžava radni vek motora, optimizira interval zamene ulja i smanjuju troškovi održavanja vozila. / Different technical systems require an appropriate lubricant to be used at an appropriate place, at appropriate time and in appropriate quantity. Determination of technical systems condition has a very important role in the development of theory and practice of friction, wear and lubrication. Lubricant is, as a contact element of tribomechanical systems, a carrier of information about the state of the whole system, from the aspect of tribological and other ageing processes. The analysis of oils, based on a properly defined program, thus represents a very effective method for monitoring the condition of technical systems, which ensures early warning signals of potential problems that could lead to failure and break down of technical systems. Introduction It is not always simple to determine a type of lubricant, frequency of lubrication and the quantity of lubricant to be used. The optimal recommendation would be to follow specifications of technical system manufacturers, experience, lab research or professional recommendation of lubricant suppliers. Rational lubricant consumption can be obtained by timely oil replacement, which then enables a maximum possible period of use as well as high-quality lubrication. Since the primary role of lubricants is to reduce negative effects of tribological processes related to friction, wear and temperature increase in tribomechanical systems, all types of maintenance include lubrication as a very important part of the whole procedure. On the other hand, lubricant is, as a contact element of the system, a carrier of information about the condition of the whole system, from the aspect of tribological and other ageing processes. Therefore, an analysis of oils, based on a properly defined program, represents a very effective method for monitoring the condition of technical systems, which ensures early warning signals of potential problems that could lead to failure and break down of technical systems. Besides mechanical components in a system structure, the condition of lubricant itself is also affected, which leads to a loss of lubricating properties. Contamination and degradation of lubricating oils There are numerous opportunities for contamination and degradation of lubricating oils. Contamination and degradation of oil exploitation cannot be completely prevented, but can be significantly reduced, which is very important both for oil and for a technical system itself. The rate and degree of degradation of oil are proportional to the rate and extent of contamination. It is therefore important to prevent rapid contamination of oil, before and during use. The spectrum of oil contaminants is considerably wide. Any contaminant destructive impact on oil, reducing its physical-chemical and working properties, results in shortening its service life as well as the service life of the technical system in question. During oil exploitation, changes occur in: chemical compositions and properties of base oils, chemical compositions and properties of additives, and consequently chemical compositions of oils in general, as a result of contamination and degradation. The most significant oil contaminants are base oils degradation products, additives degradation products, metal particles as a result of wear processes, solid particles from the environment, water and products of fuel combustion. During the operation the following changes occur: contamination of oil by the products of its own degradation, by products of incomplete combustion of fuel and by contaminants of various origin. The main objectives of the analysis and monitoring of oil exploitation in vehicles The main objectives of the analysis and monitoring of oil exploitation in vehicles are: - analysis of system element wear processes, - analysis of lubricant contamination processes, - monitoring changes in the properties of lubricants in order to optimize the life of system functionality control (penetration of contaminants, temperature and pressure, filter efficiency, etc. and - determining the extent of damage and causes of failure. The analysis of the contents of different metals in lubricants is very important. Metal particles are abrasive, and act as catalysts in oil oxidation. In motor oils, they can originate from additives, wear processes, fuel, air and cooling liquid. Metals from additives may be Zn, Ca, Ba, or Mg and they indicate additive deterioration. Metals originating from wear are: Fe, Pb, Cu, Cr, Al, Mn, Ag, Sn, and they point to increased wear in these systems. The elements originating from cooling liquids are Na and B, and their increased content indicates the penetration of cooling liquid in the lubricant. The increased content of Si or Ca, which originate from the air, points to a malfunction of the air filter. Condition monitoring through oil analysis tests There are many different types of oil analysis tests that are used to evaluate lubricants. The tests must cover three areas: technical system condition, contamination condition, and lubricant condition. From the technical system condition aspect, attention should be paid to the presence of any metal particles in oil and the tendencies in their change. The second focus would be the lubricant condition, especially viscosity change, increase in oxidation, and signs of additive depletion. The third focus would be impurities, where the emphasis should be placed on particle number, water content and metal impurities. Theoretically, oil analyses are divided into three classes. In reality, all three condition-monitoring classes are interrelated and must be considered as a whole. For example, an increase in viscosity could be an indication that a lubricant is oxidizing. But oxidation could be an incorrect conclusion, if there is no indication of an increasing oxidation tendency obtained either by the acid number (AN values analysis or the Fourier Transform-Infrared (FT-IR analysis. Lubricant monitoring enables its refreshing or replacement before serious technical system damage occurs. If damage is noticed in the course of operation, and is caused by impurities or lubricant problems, the technical system condition can be monitored and the system may be shut down immediately to minimize damage. There are the two types of alarms, i.e. warning signs used in oil analysis: absolute and statistical alarms. An effective oil analysis relies on the combination of both types. The warning limit is the absolute alarm. The statistical tendency takes into account variability based on oil sampling and its contamination and represents the standard deviation. The deviation from the normal variability indicates serious problems, which is the first signal for taking action and dealing with the problem. As the deviation tendency approaches the warning limit, oil replacement, oil purification or a system inspection is required. Metal particles content and viscosity or some other parameters can be tested. The normal variability range takes into account minor variations caused by analytical accuracy, sample homogeneity, etc. Statistical alarms, which provide the earliest possible warning without false alarms, are difficult to achieve. The factors such as oil adding or changing, filter changes and a sampling technique can distort the results. The following tests are most frequently used in technical system condition monitoring: - Spectrometric Analysis, - Analytical Ferrography, - Rotrode Filter Spectroscopy (RFS, - Infrared Analysis (FT-IR, - Viscosity, - Total acid number (TAN, - Total Base Number (TBN - Water and Particle Count.

  15. PROMENE KRVNOG PRITISKA U TOKU TESTA FIZIČKIM OPTEREĆENJEM KOD NORMOTENZIVNIH I HIPERTENZIVNIH REKREATIVACA

    Directory of Open Access Journals (Sweden)

    Mirko Šaranović

    2008-08-01

    Full Text Available Background. Arterial hypertension is a leading cause of morbidity in developed countries. It often decreases functional capacities of the cardiovascular system. Changes of pressure during physical exercise are a very significant a prognostic factor. Aim. The aim of this investigation was to assess changes of blood pressure and heart rate during exercise in normotensive and hypertensive men involved in recreational physical activity. Methods. The study included 90 young men (aged 30-40 years involved in recreation (60 with hypertension, 30 with normal pressure. The bicycle ergometer test was performed after rest, the load increased gradually from 50 to 125W. Blood pressure and heart rate were measured at rest and during the exercise. Results. Systolic and diastolic pressure increased signifi cantly in both groups during the ergometry test, compared to the values at rest. This increase was higher among hypertensive men for every graduation of test load (p<0.05. Heart rate was similar in both groups at rest, but higher values were noted among hypertensive men (p<0.05.

  16. Growth of a plasmid-bearing (pYV) Yersinia pestis KIM5 in retail raw ground pork

    Science.gov (United States)

    Yersinia pestis can cause oro-pharyngeal plague as a result of consumption or handling of meat from infected animals. Thus, food naturally or intentionally contaminated can have a role in the dissemination of human plague. The growth of a conditionally virulent plasmid (pYV)-bearing rifampicin-res...

  17. VizieR Online Data Catalog: Low-resolution near-infrared stellar spectra from CIBER (Kim+, 2017)

    Science.gov (United States)

    Kim, M. G.; Lee, H. M.; Arai, T.; Bock, J.; Cooray, A.; Jeong, W.-S.; Kim, S. J.; Korngut, P.; Lanz, A.; Lee, D. H.; Lee, M. G.; Matsumoto, T.; Matsuura, S.; Nam, U. W.; Onishi, Y.; Shirahata, M.; Smidt, J.; Tsumura, K.; Yamamura, I.; Zemcov, M.

    2017-06-01

    We present flux-calibrated near-infrared spectra of 105 stars from 0.8{skin, we do not use the first flight data in this work. The star spectral types are determined by fitting known spectral templates to the measured LRS spectra. We use the Infrared Telescope Facility (IRTF) and Pickles 1998 (Cat. J/PASP/110/863) templates for the SED fitting. The SpeX instrument installed on the IRTF observed stars using a medium-resolution spectrograph (R=2000). The template library contains spectra for 210 cool stars (F to M type) with wavelength coverage from 0.8 to 2.5μm (Cushing 2005ApJ...623.1115C; Rayner 2009ApJS..185..289R). The Pickles library is a synthetic spectral library that combines spectral data from various observations to achieve wavelength coverage from the UV (0.115μm) to the near-infrared (2.5μm). It contains 131 spectral templates for all star types (i.e., O to M type) with a uniform sampling interval of 5Å. (6 data files).

  18. Estimation of spawning area of Pisodonophis sangjuensis Ji and Kim, 2011 (Pisces: Ophichthidae) based on leptocephali size and distribution

    Science.gov (United States)

    Ji, Hwan-Sung; Hwang, Kangseok; Choi, Jung Hwa; Cha, Hyung-Kee; Kim, Jin-Koo

    2017-06-01

    Pre-metamorphic leptocephali of Pisodonophis sangjuensis ( n = 91, 10.4-90.2 mm in total length, TL) were collected in the East China Sea for the first time. Pre-metamorphic leptocephali of P. sangjuensis, which were identified using mitochondrial DNA cytochrome c oxidase subunit I gene (mtDNA COI), are characterized by various combinations of morphological characters: 8 moderate to pronounced gut loops with the kidney terminating on the 6-7th loops; and 8 subcutaneous pigment patches on the tail just ventral to the notochord. Pisodonophis sangjuensis leptocephali were more numerously collected offshore than inshore around Jeju Island. The smallest leptocephali ( 100.0 mm TL) were collected from around Jeju Island and the southern coast of Korea. Our findings indicate that P. sangjuensis spawns offshore south of Jeju Island that is an area associated with high water temperature, and then the hatched leptocephali are transported to Jeju Island or the southern coast of Korea by the Tsushima Warm Current.

  19. Support for harmful treatment and reduction of empathy toward blacks: "Remnants" of stereotype activation involving Hurricane Katrina and "Lil' Kim"

    NARCIS (Netherlands)

    Johnson, J.D.; Bushman, B.J.

    2008-01-01

    Two experiments involving White participants tested the influence of media-based Black stereotypes on subsequent responses to Black and White persons-in-need. Experiment 1 showed that priming the "Black criminal" stereotype through exposure to photographs of Blacks looting after Hurricane Katrina

  20. Report on the Second KIMS-CNA Conference: The PLA Navys Build-Up and ROK-USN Cooperation

    Science.gov (United States)

    2009-02-01

    Modernization (London and Washington, DC: Kegan Paul International and The AEI Press, 1996), p. 274. See also his “China’s Push Through the South China Sea...to change its nature of the PLA Navy naval strategy from “brown water” force to “ green /blue water” navy enable to secure its vast maritime...and “full ocean-going green water fleet.” It is conceivable that the Chinese navy’s goal of its operational capability is not “blue water navy,” but

  1. VizieR Online Data Catalog: ChaMP X-ray point source catalog (Kim+, 2007)

    Science.gov (United States)

    Kim, M.; Kim, D.-W.; Wilkes, B. J.; Green, P. J.; Kim, E.; Anderson, C. S.; Barkhouse, W. A.; Evans, N. R.; Ivezic, Z.; Karovska, M.; Kashyap, V. L.; Lee, M. G.; Maksym, P.; Mossman, A. E.; Silverman, J. D.; Tananbaum, H. D.

    2009-01-01

    We present the Chandra Multiwavelength Project (ChaMP) X-ray point source catalog with ~6800 X-ray sources detected in 149 Chandra observations covering ~10deg2. The full ChaMP catalog sample is 7 times larger than the initial published ChaMP catalog. The exposure time of the fields in our sample ranges from 0.9 to 124ks, corresponding to a deepest X-ray flux limit of f0.5-8.0=9x10-16ergs/cm2/s. The ChaMP X-ray data have been uniformly reduced and analyzed with ChaMP-specific pipelines and then carefully validated by visual inspection. The ChaMP catalog includes X-ray photometric data in eight different energy bands as well as X-ray spectral hardness ratios and colors. To best utilize the ChaMP catalog, we also present the source reliability, detection probability, and positional uncertainty. (10 data files).

  2. VizieR Online Data Catalog: NIR polarimetric study in the LMC N159/N160 field (Kim+, 2017)

    Science.gov (United States)

    Kim, J.; Jeong, W.-S.; Pyo, J.; Pak, S.; Park, W.-K.; Kwon, J.; Tamura, M.

    2018-04-01

    Simultaneous JHKs polarimetric observations of the N159/N160 c were performed on 2007 February 3 and 5. We used the near-infrared camera SIRIUS (Nagayama et al. 2003SPIE.4841..459N) and the polarimeter SIRPOL (Kandori et al. 2006SPIE.6269E..51K) of the Infrared Survey Facility (IRSF) 1.4 m telescope at the South African Astronomical Observatory in Sutherland, South Africa. The camera has a field of view of 7.7"x7.7" and a pixel scale of 0.45"/pixel. One set of observations for a target field consisted of 20 s exposures at 10 dithered positions for four wave-plate angles (0°, 45°, 22.5°, and 67.5°) in the J, H, and Ks bands, and the whole sequence is repeated 10 and 9 times for the N159 and N160 fields centered at (α, δ)2000=(5h39m37.1s, -69°43'45.1") and (5h40m05.6s, -69°36'25.8"), respectively. (2 data files).

  3. ANALYSIS OF CORNEAL ASTIGMATISM BEFORE AND AFTER PTERYGIUM SURGERY- A PROSPECTIVE STUDY IN PATIENTS ATTENDING KIMS, HUBLI

    Directory of Open Access Journals (Sweden)

    Y. B. Bajantri

    2017-10-01

    Full Text Available BACKGROUND Pterygium is a very common degenerative condition seen in Indian subcontinent. It is a wing-shaped fibrovascular encroaching up on the cornea from either sides. The prevalence rate is 5.2%. Pterygium is known to affect refractive astigmatism. The induced astigmatism may become significant to cause visual distortion, even though the pterygium remains distant from visual axis induced astigmatism maybe either “with-the-rule” or “against-the-rule.” The aim of the study is to- 1. Compare preoperative with postoperative astigmatism in case of pterygium. 2. Assess the amount of astigmatism in case of pterygia of different lengths measured from the limbus over the cornea. MATERIALS AND METHODS The study included 70 eyes of 70 patients with primary pterygium. Preoperative evaluation included pterygium size, visual acuity, keratometry and refraction with subjective correction. Patients included in the study were divided into three groups based on length of pterygium encroaching on cornea (1 to 2 mm, 2 to 3 mm, >3 mm. Each eye underwent bare sclera pterygium excision. Postoperative visual acuity, keratometry and refraction were evaluated on 1st day, at the end of 1st week, 4 th week and 9th week. The pre and postoperative results were compared and analysed. RESULTS An average of all 70 cases with mean pterygium length 3.2 mm had a mean keratometry astigmatism of 1.84 ± 0.89D preoperatively and 0.514 ± 0.52D postoperatively indicating a reduction of pterygium-induced corneal astigmatism by 1.45 ± 0.77D (p value <0.0001, which was statistically significant. CONCLUSION Pterygium-induced corneal astigmatism is directly proportional to the size of the pterygium. Thus, early surgical excision reduces the corneal astigmatism, and hence, improves the visual acuity.

  4. Subsurface temperature estimation from climatology and satellite SST for the sea around Korean Peninsula 1Bong-Guk, Kim, 1Yang-Ki, Cho, 1Bong-Gwan, Kim, 1Young-Gi, Kim, 1Ji-Hoon, Jung 1School of Earth and Environmental Sciences, Seoul National University

    Science.gov (United States)

    Kim, Bong-Guk; Cho, Yang-Ki; Kim, Bong-Gwan; Kim, Young-Gi; Jung, Ji-Hoon

    2015-04-01

    Subsurface temperature plays an important role in determining heat contents in the upper ocean which are crucial in long-term and short-term weather systems. Furthermore, subsurface temperature affects significantly ocean ecology. In this study, a simple and practical algorithm has proposed. If we assume that subsurface temperature changes are proportional to surface heating or cooling, subsurface temperature at each depth (Sub_temp) can be estimated as follows PIC whereiis depth index, Clm_temp is temperature from climatology, dif0 is temperature difference between satellite and climatology in the surface, and ratio is ratio of temperature variability in each depth to surface temperature variability. Subsurface temperatures using this algorithm from climatology (WOA2013) and satellite SST (OSTIA) where calculated in the sea around Korean peninsula. Validation result with in-situ observation data show good agreement in the upper 50 m layer with RMSE (root mean square error) less than 2 K. The RMSE is smallest with less than 1 K in winter when surface mixed layer is thick, and largest with about 2~3 K in summer when surface mixed layer is shallow. The strong thermocline and large variability of the mixed layer depth might result in large RMSE in summer. Applying of mixed layer depth information for the algorithm may improve subsurface temperature estimation in summer. Spatial-temporal details on the improvement and its causes will be discussed.

  5. Panel discussion on rock mechanics issues in repository design

    International Nuclear Information System (INIS)

    Bieniawski, Z.T.; Kim, K.S.; Nataraja, M.

    1996-01-01

    The panel discussion was introduced by Mr. Z.T.(Richard) Bieniawski and then continued with five additional speakers. The topics covered in the discussion included rock mechanics pertaining to the design of underground facilities for the disposal of radioactive wastes and the safety of such facilities. The speakers included: Mr. Kun-Soo Kim who is a specialist in the area of rock mechanics testing during the Basalt Waste Isolation Project; Dr. Mysore Nataraja who is the senior project manager with the NRC; Dr. Michael Voegele who is the project manager for Science Applications International Corporation (SAIC) on the Yucca Mountain Project; Dr. Edward Cording who is a member of the Nuclear Waste Technical Review Board; and Dr. Hemendra Kalia who is employed by Los Alamos National Laboratory and coordinates various activities of testing programs at the Yucca Mountain Site

  6. Safety assessment of silica and zinc oxide nanoparticles

    Directory of Open Access Journals (Sweden)

    An SSA

    2014-12-01

    Full Text Available Seong Soo A An,1 Meyoung-Kon Kim2 1Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, Gyeonggi, Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, KoreaThe current volume is a special issue focusing on a safety assessment of nanoparticles, from their physicochemical properties to government regulations. It features twenty-five papers, discussing general issues with the possible harmfulness of two different types of nanoparticles (NPs; silica (SiO2 and zinc oxide (ZnO. Six papers describe detailed analyses from 90-day repeated administrations of NPs, and finally there is a series of technical reports, formatted by the National Toxicology Program (NTP, dealing with safety issues regarding international cooperation with the OECD (Organisation for Economic Co-operation and Development Working Party on Manufactured Nanomaterials (WPMN.

  7. Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process

    Directory of Open Access Journals (Sweden)

    Kim MS

    2011-11-01

    Full Text Available Min-Soo Kim1, Jeong-Soo Kim1, Hee Jun Park1, Won Kyung Cho1,3, Kwang-Ho Cha1,3, Sung-Joo Hwang2,31College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea, 2College of Pharmacy, 3Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of KoreaBackground: The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS process.Methods: First, excipients for enhancing the stability and solubility of sirolimus were screened. Second, using the SAS process, solid dispersions of sirolimus-polyvinylpyrrolidone (PVP K30 nanoparticles were prepared with or without surfactants such as sodium lauryl sulfate (SLS, tocopheryl propylene glycol succinate, Sucroester 15, Gelucire 50/13, and Myrj 52. A mean particle size of approximately 250 nm was obtained for PVP K30-sirolimus nanoparticles. Solid state characterization, kinetic solubility, powder dissolution, stability, and pharmacokinetics were analyzed in rats.Results: X-ray diffraction, differential scanning calorimetry, and high-pressure liquid chromatography indicated that sirolimus existed in an anhydrous amorphous form within a solid dispersion of nanoparticles and that no degradation occurred after SAS processing. The improved supersaturation and dissolution of sirolimus as a solid dispersion of nanoparticles appeared to be well correlated with enhanced bioavailability of oral sirolimus in rats. With oral administration of a solid dispersion of PVP K30-SLS-sirolimus nanoparticles, the peak concentration and AUC0→12h of sirolimus were increased by approximately 18.3-fold and 15.2-fold, respectively.Conclusion: The results of this study suggest that preparation of PVP K30-sirolimus-surfactant nanoparticles using the SAS process may be a promising approach for improving the bioavailability of sirolimus

  8. Article 12 of the Directive 2013/48/EU: A Starting Point for Discussion on a Common Understanding of the Criteria for Effective Remedies of Violation of the Right to Counsel / Anneli Soo

    Index Scriptorium Estoniae

    Soo, Anneli, 1984-

    2017-01-01

    Euroopa Liidu direktiivi, mis käsitleb õigust kaitsjale kriminaalmenetluses ja Euroopa vahistamismäärusega seotud menetluses ning õigust lasta teavitada vabaduse võtmisest kolmandat isikut ja suhelda vabaduse võtmise ajal kolmandate isikute ja konsulaarasutustega,õiguskaitsevahendeid käsitlevast artiklist 12

  9. ’n Vergelyking van die Mollusca-diversiteit in die Mooirivier (Noordwes-Provinsie soos gevind met opnames wat gemaak is in 1963 en weer 50 jaar later

    Directory of Open Access Journals (Sweden)

    Cornelius T. Wolmarans

    2015-02-01

    Full Text Available Die hoogste getal gedokumenteerde uitsterwings van enige belangrike taksonomiese groepword aan die Mollusca toegedig. Faktore wat hoofsaaklik hiervoor verantwoordelik is, sluitonder meer omgewingsveranderinge en antropogeniese impakte in wat tot die tot niet gaanvan die habitat aanleiding gee. Daarbenewens is die bewaringstatus van minder as 2% van dieongeveer 7000 molluskspesies wêreldwyd bekend tot dusver nog nie behoorlik geassesseernie. Die doel van die huidige ondersoek wat in 2014 uitgevoer is, was om die molluskdiversiteitvan die Mooirivier met die resultate van 1963 te vergelyk. Dit is gedoen deur ’n opnameuit te voer van die molluskdiversiteit by dieselfde lokaliteite as in 1963. Twee opnames isgemaak tydens ’n vroeë- en laatlaagvloeiperiode in 2014 by agt lokaliteite wat met dié vandie 1963-opnames ooreenstem. Die pH, elektriese geleiding (EG en temperatuur is ook byelk van die lokaliteite gemeet. Die identiteit van die 14 slakspesies wat in 1963 gevind is, hetooreengestem met 14 van die 15 in 2014. Die uitheemse indringerspesie Physa acuta is tydensdie 2014-opname vir die eerste keer in hierdie rivier gevind, waarskynlik weens ’n toename inorganiese verryking. In die 1963-opname is Burnupia mooiensis en Pisidium langlyanum by diemeeste lokaliteite gevind, en in 2014 Gyraulus connollyi en Ferrissia cawstoni. Die meeste van diemolluske uit hierdie gebied wat voorheen op rekord gestel is, is in 2014 gevind. Die pH watin 2014 ’n geringe tot aansienlike verlaging getoon het, word aan mynversuring toegeskryfen het nie ’n merkbare invloed op die molluskdiversiteit gehad nie. Die hoër elektriesegeleiding wat tydens die 2014-opname gemeet is, het vanweë die verdraagsaamheid vanvarswatermolluske in hierdie verband, ook geen verandering in die molluskdiversiteit teweeggebring nie. Die temperatuur was in die laatlaagvloei deurgaans hoër. Ondanks die feit dathierdie studies vyf dekades uitmekaar gedoen is en antropogeniese impakte toegeneem het, isgeen noemenswaardige verandering in die molluskdiversiteit waargeneem nie.

  10. Remuneration of Graduates, as at 1 July 1994. Legal, Religious, Social Science, Humanities and Related Occupations = Vergoeding van Gegradueerdes, soos op 1 Julie 1994. Regs-, Godsdiens-, Sosiaal- en Verwante Geesteswetenskaplike Beroepe.

    Science.gov (United States)

    Jacobs, Johan

    This document, which is based on data gathered during a September 1994 mail survey of 215,284 South African graduates that elicited a total response rate of 18.3%, details the remuneration of graduates (as of July 1, 1994) in a wide range of occupations in the following categories: legal; religious; social science; humanities; and art, sport, and…

  11. Karistusõiguslik hädakaitse ja hädaseisund põhiõiguste piiramise alusena koolides ning nende suhestumine 1. jaanuaril 2016 jõustuva lastekaitseseaduse § 24 lõikega 3 / Anneli Soo

    Index Scriptorium Estoniae

    Soo, Anneli, 1984-

    2015-01-01

    Analüüs 1. jaanuaril 2016 jõustuva LaKS § 24 lõike 3 tähendusest teo õigusvastasust välistava asjaoluna ning kas see harmoneerub karistusõiguse dogmaatikaga hädakaitse ja hädaseisundi valdkonnas. Füüsilise vägivalla kasutamisest hädakaitse ja hädaseisundi olukorras koolis, vastavast kohtupraktikast

  12. Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles

    Directory of Open Access Journals (Sweden)

    Naeem M

    2015-07-01

    Full Text Available Muhammad Naeem, Jiafu Cao, Moonjeong Choi, Woo Seong Kim, Hyung Ryong Moon, Bok Luel Lee, Min-Soo Kim, Yunjin Jung, Jin-Wook Yoo College of Pharmacy, Pusan National University, Busan, South Korea Abstract: Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive methacrylate copolymer for the treatment of colitis. The therapeutic potential of the enzyme/pH dual-sensitive nanoparticles was evaluated using a rat colitis model and compared to single pH-triggered nanoparticles. Clinical activity scores, colon/body weight ratios, myeloperoxidase activity, and proinflammatory cytokine levels were markedly decreased by dual-sensitive nanoparticles compared to single pH-triggered nanoparticles and budesonide solution. Moreover, dual-sensitive nanoparticles accumulated selectively in inflamed segments of the colon. In addition, dual-sensitive nanoparticle plasma concentrations were lower than single pH-triggered nanoparticles, and no noticeable in vitro or in vivo toxicity was observed. Our results demonstrate that enzyme/pH dual-sensitive nanoparticles are an effective and safe colon-targeted delivery system for colitis therapy. Keywords: azo-polyurethane, methacrylate copolymer, budesonide, colon-targeted nanoparticles, colitis

  13. The prevalence of musculoskeletal disorders and occupational risk factors in Kashan SAIPA automobile industry workers by key indicator method (KIM), 1390

    OpenAIRE

    2012-01-01

    Introduction: work related musculoskeletal disorders are the most wide spread type of occupational diseases among workers. Awkward body postures during work and manual material handling are among the most important risk factors of musculoskeletal disorders in different jobs. Due to importance of recognizing these factors prevalence and risk factor of work related musculoskeletal disorders, this research was aimed to study the among employees of Kashan City’s Saipa automobile industry in 2...

  14. First experience under the exemption regime of EC Regulation 1228/2003 on Conditions for Access to the Network of Cross-Border Exchanges in Electricity / Kim Talus

    Index Scriptorium Estoniae

    Talus, Kim

    2005-01-01

    23. aprillil 2005 Euroopa Komisjoni poolt vastu võetud otsusest anda roheline tuli Estlink'i projektile, mis tähendab koostööd Eesti ja Soome elektrivõrkude vahel ; Euroopa Komisjon võttis aluseks regulatsiooni nr. 1228/2003 artikli 7

  15. Whole-genome sequencing reveals that Shewanella haliotis Kim et al. 2007 can be considered a later heterotypic synonym of Shewanella algae Simidu et al. 1990.

    Science.gov (United States)

    Szeinbaum, Nadia; Kellum, Cailin E; Glass, Jennifer B; Janda, J Michael; DiChristina, Thomas J

    2018-04-01

    Previously, experimental DNA-DNA hybridization (DDH) between Shewanellahaliotis JCM 14758 T and Shewanellaalgae JCM 21037 T had suggested that the two strains could be considered different species, despite minimal phenotypic differences. The recent isolation of Shewanella sp. MN-01, with 99 % 16S rRNA gene identity to S. algae and S. haliotis, revealed a potential taxonomic problem between these two species. In this study, we reassessed the nomenclature of S. haliotis and S. algae using available whole-genome sequences. The whole-genome sequence of S. haliotis JCM 14758 T and ten S. algae strains showed ≥97.7 % average nucleotide identity and >78.9 % digital DDH, clearly above the recommended species thresholds. According to the rules of priority and in view of the results obtained, S. haliotis is to be considered a later heterotypic synonym of S. algae. Because the whole-genome sequence of Shewanella sp. strain MN-01 shares >99 % ANI with S. algae JCM 14758 T , it can be confidently identified as S. algae.

  16. Acceptance of Gold Medal From the Catalan Society of Transplantation by Drs. Lorraine Racusen and Kim Solez - With Remarks on the Banff Meeting Spirit.

    Science.gov (United States)

    Racusen, L C; Solez, K

    2017-12-01

    The awarding of the gold medal from the Catalan Society of Transplantation to the organizers of the Banff Transplant Pathology meetings is an opportunity to acknowledge gratitude to all the people who have helped make these meetings a success over the past 26 years. Other large organizations have given up consensus conferences, but the Banff consensus process is thriving. It is unusual for any organization to have the same leadership for 26 years. It has only worked for the Banff meetings because the leadership was flexible and able to change with the times. People have often talked about the "special Banff spirit." This year's meeting gave us the opportunity to examine this spirit in detail by analyzing how the meeting consensus sessions and social events functioned. The meeting has never used expert facilitators, but instead has employed experts within the transplant pathology community to moderate discussions. The size of the working sessions is important; they have usually been less than 150 people, which is within "Dunbar's number," meaning that in gatherings of that size one can have empathetic feeling for all the people there. In larger gatherings one loses that "we are all in this together" feeling and people begin thinking "us" versus "them" thoughts. For "unknown" young people the ability to easily talk to well-known leaders in the field is rewarding and keeps them coming back for more time after time. Images of the social events do not suggest any sort of hierarchy; everyone interacts with everyone else. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  17. A. Kim, k.f. Anderson, j. Berliner, j. Hassan, j. Jensen, h.j. Mertz, h. Pietsch, a. Rao, R. Scherer, and a. Sutterfield.

    Science.gov (United States)

    Kim, A; Anderson, K F; Berliner, J; Hassan, J; Jensen, J; Mertz, H J; Pietsch, H; Rao, A; Scherer, R; Sutterfield, A

    2003-10-01

    In this study, three dummies were evaluated on the component level and as a whole. Their responses were compared with available volunteer and embalmed Post Mortem Human Subject (PMHS) data obtained under similar test conditions to evaluate their biofidelity. The volunteer and PMHS data, used as comparators in this study, were used previously to establish some of the biofidelity requirements of the Hybrid III. The BioRID II, the Hybrid III, and the RID2 were all subjected to rear impact HYGE sled tests with deltaVs of 17 and 28 km/hr to determine their biofidelity in these conditions. A static pull test, where a load was manually applied to the head of each dummy, was used to evaluate the static strength of their necks in flexion and extension. Finally, pendulum tests were conducted with the Hybrid III and RID2 to evaluate the dynamic characteristics of their necks in flexion and extension. The sled test results indicate that out of the three dummies, the overall flexibility of the Hybrid III is comparable to that of the volunteer anticipating the impact. The overall flexibilities of the BioRID II and the RID2 are greater than those of all the comparators used in this study (the tensed volunteer and the two embalmed PMHSs). The responses of the Hybrid III are closer to those of the tensed volunteer than those of the PMHSs. The responses of the BioRID II and the RID2 are closer to those of the PMHSs than to the tensed volunteer.

  18. RAZLIKE U NEKIM MOTORIČKIM SPOSOBNOSTIMA KOD UČENIKA OBUHVAĆENIM NASTAVNIM I VANNASTAVNIM AKTIVNOSTIMA IZ KOŠARKE

    Directory of Open Access Journals (Sweden)

    Miodrag Kocić

    2005-05-01

    Full Text Available The aim of this research was to determine the effects that the third class of physical education during one term had on the mobility of the students tested. 101 students, who were divided into two groups, took part in the research. The first group, which was the control group, was made up of 50 students and the second group was made up of the remaining 51 students who were members of the basketball section. The system for measuring mobility encompassed six different disciplines: the high jump, 20 meters high start race, pull-ups, press-ups, forward bend (and lifting the upper part of the body on the bench. All the results of the research were processed in a usual way giving the information on central and dispersion statistics for all disciplines. The differences between the groups were determined by discriminative analysis

  19. Upotreba Kaizen filozofije u upravljačkim strukturama kompanija u Srbiji / The Use of Keizen Philosophy in the Managing Structures in the Companies in Serbia

    Directory of Open Access Journals (Sweden)

    Simona Žikić

    2016-11-01

    Full Text Available In the moment when there is a question mark over the economy of every country and the markets are not stable, but ever changing, moving forward, and/or collapsing, one of the most successful approaches to the survival and improvement of the management of the companies is Keizen concept. Keizen concept of management is philosophy that is initially used in Japan, where it comes from, but in other places all around the world as well, mostly in America and the countries in Western civilization. Keizen philosophy is the concept of continuous improvement, which, strategically observed, contributes improvement and prosperity of the companies. Having in mind its occurrence, the first results of Keizen philosophy’s approach can be identified in the development of Japanese economy, which reached unbelievable results and improvement only few years after the Second World War. Japanese companies very soon became competitive at the global market thanks to Kaizen philosophy, no matter the fact that his approach includes managing concepts and concepts of business organization which are diametrically opposite to the current dominant opinion and application of the concepts of managing business organization from the Western companies. This is the reason why the idea of this paper is to show the main values that are in the core of Kaizen philosophy and to show that the application of this business  concept is possible in Serbia, besides the small number of those who already did it. The aim of this paper is to bring closer the importance of the development of human resources and their influence on the structure of the companies’ management, because only with the human resources department based well, there is a possibility of Keizen philosophy application.

  20. Analisis Kandungan Timbal (Pb) Dan Kadmium (Cd) Pada Kangkung Air (Ipomoea aquatica Forssk) DAN kangkung Darat (Ipomoea reptans Poir) Di Daerah Mabar-Kim Secara Spektrofotometri Serapan Atom

    OpenAIRE

    Sari, Arisa Dian

    2011-01-01

    Kangkung is a kind of vegetables that is commonly consumed by people and it contains a lot of vitamin A. Surrounding the Industry Area in Medan such as Mabar, vegetables are planted by people, one of them is kangkung. Since the industries growth in the area of the vegetables are expanded, it is wondered that the kangkung has been contaminated by lead and cadmium metals. The purpose of this research is to know the lead and cadmium metals of water kangkung and land kangkung planted in Mabar the...

  1. In vitro cytotoxicity of SiO2 or ZnO nanoparticles with different sizes and surface charges on U373MG human glioblastoma cells

    Directory of Open Access Journals (Sweden)

    Kim JE

    2014-12-01

    Full Text Available Jung-Eun Kim,1,* Hyejin Kim,1,* Seong Soo A An,2 Eun Ho Maeng,3 Meyoung-Kon Kim,4 Yoon-Jae Song1 1Department of Life Science, 2Department of Bionano Technology, Gachon University, Seongnam-Si, South Korea; 3Korea Testing and Research Institute, Seoul, South Korea; 4Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea *These authors contributed equally to this work Abstract: Silicon dioxide (SiO2 and zinc oxide (ZnO nanoparticles are widely used in various applications, raising issues regarding the possible adverse effects of these metal oxide nanoparticles on human cells. In this study, we determined the cytotoxic effects of differently charged SiO2 and ZnO nanoparticles, with mean sizes of either 100 or 20 nm, on the U373MG human glioblastoma cell line. The overall cytotoxicity of ZnO nanoparticles against U373MG cells was significantly higher than that of SiO2 nanoparticles. Neither the size nor the surface charge of the ZnO nanoparticles affected their cytotoxicity against U373MG cells. The 20 nm SiO2 nanoparticles were more toxic than the 100 nm nanoparticles against U373MG cells, but the surface charge had little or no effect on their cytotoxicity. Both SiO2 and ZnO nanoparticles activated caspase-3 and induced DNA fragmentation in U373MG cells, suggesting the induction of apoptosis. Thus, SiO2 and ZnO nanoparticles appear to exert cytotoxic effects against U373MG cells, possibly via apoptosis. Keyword: apoptosis

  2. AXENIC IN-VITRO NITROGEN AND PHOSPHORUS RESPONSES OF SOME DUTCH MARSH ORCHIDS

    NARCIS (Netherlands)

    DIJK, E; ECK, N

    1995-01-01

    Seedlings of Dactylorhiza majalis (Reichb.) Hunt & Summerh., D. praetermissa (Druce) Soo var.junialis (Vermen.) Sengh., D. incarnata (L.) Soo and D. maculata (L.) Soo ssp. maculata were grown axenically in vitro at various concentrations of ammonium nitrate and phosphate to assess the extent of

  3. Enhancement of the dissolution rate and bioavailability of fenofibrate by a melt-adsorption method using supercritical carbon dioxide

    Directory of Open Access Journals (Sweden)

    Cha KH

    2012-10-01

    Full Text Available Kwang-Ho Cha,1,3 Kyung-Jin Cho,3 Min-Soo Kim,4 Jeong-Soo Kim,3 Hee Jun Park,1,3 Junsung Park,1,3 Wonkyung Cho,1,3 Jeong-Sook Park,3 Sung-Joo Hwang1,21Yonsei Institute of Pharmaceutical Sciences, 2College of Pharmacy, Yonsei University, Incheon, Republic of Korea; 3College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; 4Department of Pharmaceutical Engineering, Inje University, Gimhae, Republic of KoreaBackground: The aim of this study was to enhance the bioavailability of fenofibrate, a poorly water-soluble drug, using a melt-adsorption method with supercritical CO2.Methods: Fenofibrate was loaded onto Neusilin® UFL2 at different weight ratios of fenofibrate to Neusilin UFL2 by melt-adsorption using supercritical CO2. For comparison, fenofibrate-loaded Neusilin UFL2 was prepared by solvent evaporation and hot melt-adsorption methods. The fenofibrate formulations prepared were characterized by differential scanning calorimetry, powder x-ray diffractometry, specific surface area, pore size distribution, scanning electron microscopy, and energy-dispersive x-ray spectrometry. In vitro dissolution and in vivo bioavailability were also investigated.Results: Fenofibrate was distributed into the pores of Neusilin UFL2 and showed reduced crystal formation following adsorption. Supercritical CO2 facilitated the introduction of fenofibrate into the pores of Neusilin UFL2. Compared with raw fenofibrate, fenofibrate from the prepared powders showed a significantly increased dissolution rate and better bioavailability. In particular, the area under the drug concentration-time curve and maximal serum concentration of the powders prepared using supercritical CO2 were 4.62-fold and 4.52-fold greater than the corresponding values for raw fenofibrate.Conclusion: The results of this study highlight the usefulness of the melt-adsorption method using supercritical CO2 for improving the bioavailability of fenofibrate.Keywords: fenofibrate

  4. Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

    Directory of Open Access Journals (Sweden)

    Ha ES

    2015-08-01

    Full Text Available Eun-Sol Ha,1 Jeong-Soo Kim,2 In-hwan Baek,3 Jin-Wook Yoo,1 Yunjin Jung,1 Hyung Ryong Moon,1 Min-Soo Kim1 1College of Pharmacy, Pusan National University, 2Dong-A ST Co Ltd, Yongin, 3College of Pharmacy, Kyungsung University, Busan, South Korea Abstract: In the present study, solid dispersion nanoparticles with a hydrophilic polymer and surfactant were developed using the supercritical antisolvent (SAS process to improve the dissolution and oral absorption of megestrol acetate. The physicochemical properties of the megestrol acetate solid dispersion nanoparticles were characterized using scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction, and a particle-size analyzer. The dissolution and oral bioavailability of the nanoparticles were also evaluated in rats. The mean particle size of all solid dispersion nanoparticles that were prepared was <500 nm. Powder X-ray diffraction and differential scanning calorimetry measurements showed that megestrol acetate was present in an amorphous or molecular dispersion state within the solid dispersion nanoparticles. Hydroxypropylmethyl cellulose (HPMC solid dispersion nanoparticles significantly increased the maximum dissolution when compared with polyvinylpyrrolidone K30 solid dispersion nanoparticles. The extent and rate of dissolution of megestrol acetate increased after the addition of a surfactant into the HPMC solid dispersion nanoparticles. The most effective surfactant was Ryoto sugar ester L1695, followed by d-a-tocopheryl polyethylene glycol 1000 succinate. In this study, the solid dispersion nanoparticles with a drug:HPMC:Ryoto sugar ester L1695 ratio of 1:2:1 showed >95% rapid dissolution within 30 minutes, in addition to good oral bioavailability, with approximately 4.0- and 5.5-fold higher area under the curve (0–24 hours and maximum concentration, respectively, than raw megestrol acetate powder. These results suggest that the preparation of megestrol

  5. Optimized formulation of solid self-microemulsifying sirolimus delivery systems

    Directory of Open Access Journals (Sweden)

    Cho W

    2013-04-01

    Full Text Available Wonkyung Cho,1,2 Min-Soo Kim,3 Jeong-Soo Kim,2 Junsung Park,1,2 Hee Jun Park,1,2 Kwang-Ho Cha,1,2 Jeong-Sook Park,2 Sung-Joo Hwang1,4 1Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea; 2College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; 3Department of Pharmaceutical Engineering, Inje University, Gimhae, Republic of Korea; 4College of Pharmacy, Yonsei University, Incheon, Republic of Korea Background: The aim of this study was to develop an optimized solid self-microemulsifying drug delivery system (SMEDDS formulation for sirolimus to enhance its solubility, stability, and bioavailability. Methods: Excipients used for enhancing the solubility and stability of sirolimus were screened. A phase-separation test, visual observation for emulsifying efficiency, and droplet size analysis were performed. Ternary phase diagrams were constructed to optimize the liquid SMEDDS formulation. The selected liquid SMEDDS formulations were prepared into solid form. The dissolution profiles and pharmacokinetic profiles in rats were analyzed. Results: In the results of the oil and cosolvent screening studies, Capryol™ Propylene glycol monocaprylate (PGMC and glycofurol exhibited the highest solubility of all oils and cosolvents, respectively. In the surfactant screening test, D-α-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS was determined to be the most effective stabilizer of sirolimus in pH 1.2 simulated gastric fluids. The optimal formulation determined by the construction of ternary phase diagrams was the T32 (Capryol™ PGMC:glycofurol:vitamin E TPGS = 30:30:40 weight ratio formulation with a mean droplet size of 108.2 ± 11.4 nm. The solid SMEDDS formulations were prepared with Sucroester 15 and mannitol. The droplet size of the reconstituted solid SMEDDS showed no significant difference compared with the liquid SMEDDS. In the dissolution study, the release amounts of

  6. Optimization and physicochemical characterization of a cationic lipid-phosphatidylcholine mixed emulsion formulated as a highly efficient vehicle that facilitates adenoviral gene transfer

    Directory of Open Access Journals (Sweden)

    Kim SY

    2017-10-01

    Full Text Available Soo-Yeon Kim,1,2 Sang-Jin Lee,2 Jin-Ki Kim,3 Han-Gon Choi,3 Soo-Jeong Lim1 1Department of Bioscience and Bioengineering, Sejong University, Seoul, Kwangjin-gu, Seoul, 2Immunotherapeutics Branch, Research Institute, National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do, 3College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, Sangnok-gu, Ansan, Republic of Korea Abstract: Cationic lipid-based nanoparticles enhance viral gene transfer by forming electrostatic complexes with adenoviral vectors. We recently demonstrated the superior complexation capabilities of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP emulsion compared with a liposomal counterpart but the cytotoxicity of DOTAP emulsions remained a challenge. The present study is aimed at formulating an emulsion capable of acting as a highly effective viral gene transfer vehicle with reduced cytotoxicity and to physicochemically characterize the structures of virus-emulsion complexes in comparison with virus–liposome complexes when the only difference between emulsions and liposomes was the presence or absence of inner oil core. The emulsion formulation was performed by 1 reducing the content of DOTAP while increasing the content of zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC, and 2 optimizing the oil content. The complexation capability of formulated DOTAP:DMPC mixed emulsions was similar to those of emulsions containing DOTAP alone while displaying significantly lower cytotoxicity. The complexation capabilities of the DOTAP:DMPC mixed emulsion were serum-compatible and were monitored in a variety of cell types, whereas its liposomal counterpart was totally ineffective. Characterization by scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and dynamic light scattering studies indicated that the optimized emulsions spontaneously surrounded the virus particles to generate emulsions that

  7. Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate

    Directory of Open Access Journals (Sweden)

    Yousaf AM

    2016-01-01

    Full Text Available Abid Mehmood Yousaf,1,2 Omer Mustapha,1 Dong Wuk Kim,1 Dong Shik Kim,1 Kyeong Soo Kim,1 Sung Giu Jin,1 Chul Soon Yong,3 Yu Seok Youn,4 Yu-Kyoung Oh,5 Jong Oh Kim,3 Han-Gon Choi1 1College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi, South Korea; 2Faculty of Pharmacy, University of Central Punjab, Johar, Lahore, Pakistan; 3College of Pharmacy, Yeungnam University, Gyongsan, North Gyeongsang, 4School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi, 5College of Pharmacy, Seoul National University, Seoul, South Korea Purpose: The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate.Methods: Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP and Labrafil® M 2125 as carriers using the electrospray technique, and the effect of the carriers on drug solubility and solvation was assessed. The solid state characterization of an optimized formulation was conducted by scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopic analyses. Oral bioavailability in rats was also evaluated for the formulation of an optimized nanospherule in comparison with free drug and a conventional fenofibrate-loaded solid dispersion.Results: All of the electrosprayed nanospherule formulations had remarkably enhanced aqueous solubility and dissolution compared with free drug. Moreover, Labrafil M 2125, a surfactant, had a positive influence on the solubility and dissolution of the drug in the electrosprayed nanospherule. Increases were observed as the PVP/drug ratio increased to 4:1, but higher ratios gave no significant increases. In particular, an electrosprayed nanospherule composed of fenofibrate, PVP, and Labrafil M 2125 at the weight ratio of 1

  8. Three-dimensional culture and interaction of cancer cells and dendritic cells in an electrospun nano-submicron hybrid fibrous scaffold

    Directory of Open Access Journals (Sweden)

    Kim TE

    2016-03-01

    Full Text Available Tae-Eon Kim,1–3,* Chang Gun Kim,1–3,* Jin Soo Kim,4 Songwan Jin,4 Sik Yoon,5 Hae-Rahn Bae,6 Jeong-Hwa Kim,7,8 Young Hun Jeong,7,8 Jong-Young Kwak1–3 1Department of Pharmacology, School of Medicine, 2Department of Biomedical Sciences, The Graduate School, Ajou University, Suwon, South Korea; 3Immune Network Pioneer Research Center, Ajou University Medical Center, Suwon, South Korea; 4Department of Mechanical Engineering, Korea Polytechnic University, Gyeonggi, South Korea; 5Department of Anatomy, School of Medicine, Pusan National University, Yangsan, South Korea; 6Department of Physiology, College of Medicine, Dong-A University, Busan, South Korea; 7School of Mechanical Engineering, 8Department of Mechanical Engineering, Graduate School, Kyungpook National University, Daegu, South Korea *These authors contributed equally to this work Abstract: An artificial three-dimensional (3D culture system that mimics the tumor microenvironment in vitro is an essential tool for investigating the cross-talk between immune and cancer cells in tumors. In this study, we developed a 3D culture system using an electrospun poly(ε-caprolactone (PCL nanofibrous scaffold (NFS. A hybrid NFS containing an uninterrupted network of nano- and submicron-scale fibers (400 nm to 2 µm was generated by deposition onto a stainless steel mesh instead of an aluminum plate. The hybrid NFS contained multiplanar pores in a 3D structure. Surface-seeded mouse CT26 colon cancer cells and bone marrow-derived dendritic cells (BM-DCs were able to infiltrate the hybrid NFS within several hours. BM-DCs cultured on PCL nanofibers showed a baseline inactive form, and lipopolysaccharide (LPS-activated BM-DCs showed increased expression of CD86 and major histocompatibility complex Class II. Actin and phosphorylated FAK were enriched where unstimulated and LPS-stimulated BM-DCs contacted the fibers in the 3D hybrid NFS. When BM-DCs were cocultured with mitoxantrone-treated CT26 cells in

  9. Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement

    Directory of Open Access Journals (Sweden)

    Yum S

    2015-08-01

    Full Text Available Soohwan Yum, Seongkeun Jeong, Sunyoung Lee, Joon Nam, Wooseong Kim, Jin-Wook Yoo, Min-Soo Kim, Bok Luel Lee, Yunjin Jung College of Pharmacy, Pusan National University, Busan, Republic of Korea Abstract: Piceatannol (PCT, an anti-colitic natural product, undergoes extensive Phase II hepatic metabolism, resulting in very low bioavailability. We investigated whether colon-targeted delivery of PCT could enhance anti-colitic effects and how therapeutic enhancement occurred at the molecular level. Molecular effects of PCT were examined in human colon carcinoma cells and inflamed colons. The anti-colitic effects of PCT in a colon-targeted capsule (colon-targeted PCT were compared with PCT in a gelatin capsule (conventional PCT in a trinitrobenzene sulfonic acid-induced rat colitis model. Colon-targeted PCT elicited greatly enhanced recovery of the colonic inflammation. In HCT116 cells, PCT inhibited nuclear factor kappaB while activating anti-colitic transcription factors, nuclear factor-erythroid 2 (NF-E2 p45-related factor 2, and hypoxia-inducible factor-1. Colon-targeted PCT, but not conventional PCT, modulated production of the target gene products of the transcription factors in the inflamed colonic tissues. Rectal administration of PCT, which simulates the therapeutic action of colon-targeted PCT, also ameliorated rat colitis and reproduced the molecular effects in the inflamed colonic tissues. Colon-targeted delivery increased therapeutic efficacy of PCT against colitis, likely resulting from multitargeted effects exerted by colon-targeted PCT. The drug delivery technique may be useful for therapeutic optimization of anti-colitic lead compounds including natural products. Keywords: piceatannol, colitis, colon-targeted delivery, multitarget, polypharmacology

  10. Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride

    Directory of Open Access Journals (Sweden)

    Baek I

    2015-06-01

    Full Text Available In-hwan Baek,1,* Eun-Sol Ha,2,* Jin-Wook Yoo,2 Yunjin Jung,2 Min-Soo Kim21College of Pharmacy, Kyungsung University, 2College of Pharmacy, Pusan National University, Busan, Republic of Korea*These authors contributed equally to this workAbstract: In this study, a gelatin microparticle-containing self-microemulsifying formulation (SMF was developed using a spray-drying method to enhance the oral delivery of the poorly water-soluble therapeutic dutasteride. The effect of the amount of gelatin and the type and amount of hydrophilic additives, namely, Gelucire® 44/14, poloxamer 407, sodium lauryl sulfate, Soluplus®, Solutol™ HS15, and D-α-tocopheryl polyethylene glycol 1000 succinate, on the droplet size, dissolution, and oral absorption of dutasteride from the SMF was investigated. Upon dispersion of the gelatin microparticle-containing SMF in water after spray-drying, the mean droplet size of the aqueous dispersion was in the range of 110–137 nm. The in vitro dissolution and recrystallization results showed that gelatin could be used as a solid carrier and recrystallization inhibitor for the SMF of dutasteride. Furthermore, combination of the gelatin microparticle-containing SMF and Soluplus enhanced the dissolution properties and oral absorption of dutasteride. The results of our study suggest that the gelatin microparticle-containing SMF in combination with Soluplus could be useful to enhance the oral absorption of dutasteride.Keywords: dissolution, solubility, bioavailability, dutasteride

  11. Diagnosis of prostate cancer via nanotechnological approach

    Directory of Open Access Journals (Sweden)

    Kang BJ

    2015-10-01

    Full Text Available Benedict J Kang,1,2,* Minhong Jeun,1,2,* Gun Hyuk Jang,1,2 Sang Hoon Song,3 In Gab Jeong,3 Choung-Soo Kim,3 Peter C Searson,4 Kwan Hyi Lee1,2 1KIST Biomedical Research Institute, 2Department of Biomedical Engineering, Korea University of Science and Technology (UST, 3Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 4Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA *These authors contributed equally to this work Abstract: Prostate cancer is one of the leading causes of cancer-related deaths among the Caucasian adult males in Europe and the USA. Currently available diagnostic strategies for patients with prostate cancer are invasive and unpleasant and have poor accuracy. Many patients have been overly or underly treated resulting in a controversy regarding the reliability of current conventional diagnostic approaches. This review discusses the state-of-the-art research in the development of novel noninvasive prostate cancer diagnostics using nanotechnology coupled with suggested diagnostic strategies for their clinical implication.Keywords: bioassay, nanomaterial, nanodevice, PSA, non-PSA biomarker, bodily fluid

  12. Improvement in the amine glass platform by bubbling method for a DNA microarray

    Directory of Open Access Journals (Sweden)

    Jee SH

    2015-10-01

    Full Text Available Seung Hyun Jee,1 Jong Won Kim,2 Ji Hyeong Lee,2 Young Soo Yoon11Department of Chemical and Biological Engineering, Gachon University, Seongnam, Gyeonggi, Republic of Korea; 2Genomics Clinical Research Institute, LabGenomics Co., Ltd., Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of KoreaAbstract: A glass platform with high sensitivity for sexually transmitted diseases microarray is described here. An amino-silane-based self-assembled monolayer was coated on the surface of a glass platform using a novel bubbling method. The optimized surface of the glass platform had highly uniform surface modifications using this method, as well as improved hybridization properties with capture probes in the DNA microarray. On the basis of these results, the improved glass platform serves as a highly reliable and optimal material for the DNA microarray. Moreover, in this study, we demonstrated that our glass platform, manufactured by utilizing the bubbling method, had higher uniformity, shorter processing time, lower background signal, and higher spot signal than the platforms manufactured by the general dipping method. The DNA microarray manufactured with a glass platform prepared using bubbling method can be used as a clinical diagnostic tool. Keywords: DNA microarray, glass platform, bubbling method, self-assambled monolayer

  13. Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization

    Directory of Open Access Journals (Sweden)

    Ha ES

    2015-06-01

    Full Text Available Eun-Sol Ha,1 In-hwan Baek,2 Jin-Wook Yoo,1 Yunjin Jung,1 Min-Soo Kim1 1College of Pharmacy, Pusan National University, 2College of Pharmacy, Kyungsung University, Busan, Republic of Korea Abstract: The present study was carried out to develop an oral formulation of pranlukast hemihydrate with improved dissolution and oral bioavailability using a surface-modified microparticle. Based on solubility measurements, surface-modified pranlukast hemihydrate microparticles were manufactured using the spray-drying method with hydroxypropylmethyl cellulose, sucrose laurate, and water and without the use of an organic solvent. The hydrophilicity of the surface-modified pranlukast hemihydrate microparticle increased, leading to enhanced dissolution and oral bioavailability of pranlukast hemihydrate without a change in crystallinity. The surface-modified microparticles with an hydroxypropylmethyl cellulose/sucrose laurate ratio of 1:2 showed rapid dissolution of up to 85% within 30 minutes in dissolution medium (pH 6.8 and oral bioavailability higher than that of the commercial product, with approximately 2.5-fold and 3.9-fold increases in area under the curve (AUC0→12 h and peak plasma concentration, respectively. Therefore, the surface-modified microparticle is an effective oral drug delivery system for the poorly water-soluble therapeutic pranlukast hemihydrate. Keywords: solubility, wettability, sucrose laurate, cellulose

  14. Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats

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    Lee JA

    2014-12-01

    Full Text Available Jeong-A Lee,1 Mi-Kyung Kim,1 Hee-Jeong Paek,1 Yu-Ri Kim,2 Meyoung-Kon Kim,2 Jong-Kwon Lee,3 Jayoung Jeong,3 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, Republic of Korea; 3Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk–do, Republic of Korea Purpose: The effects of particle size on the tissue distribution and excretion kinetics of silica nanoparticles and their biological fates were investigated following a single oral administration to male and female rats. Methods: Silica nanoparticles of two different sizes (20 nm and 100 nm were orally administered to male and female rats, respectively. Tissue distribution kinetics, excretion profiles, and fates in tissues were analyzed using elemental analysis and transmission electron microscopy. Results: The differently sized silica nanoparticles mainly distributed to kidneys and liver for 3 days post-administration and, to some extent, to lungs and spleen for 2 days post-administration, regardless of particle size or sex. Transmission electron microscopy and energy dispersive spectroscopy studies in tissues demonstrated almost intact particles in liver, but partially decomposed particles with an irregular morphology were found in kidneys, especially in rats that had been administered 20 nm nanoparticles. Size-dependent excretion kinetics were apparent and the smaller 20 nm particles were found to be more rapidly eliminated than the larger 100 nm particles. Elimination profiles showed 7%–8% of silica nanoparticles were excreted via urine, but most nanoparticles were excreted via feces, regardless of particle size or sex. Conclusion: The kidneys, liver, lungs, and spleen were found to be the target organs of orally-administered silica nanoparticles in rats, and this organ

  15. Comparative analysis of nanotechnology awareness in consumers and experts in South Korea

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    Kim YR

    2014-12-01

    Full Text Available Yu-Ri Kim,1 Eun Jeong Lee,1 Sung Ha Park,2 Hyo Jin Kwon,3 Seong Soo A An,4 Sang Wook Son,5 Young Rok Seo,6 Jae-Eun Pie,7 Myoung Yoon,8 Ja Hei Kim,8 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 2Department of Biochemistry, University of Bath, Bath, UK; 3Department of Medical Education, Korea University Medical School and College, Seoul, South Korea; 4Department of Bionanotechnology, Gachon University, Seongnam, Gyeonggi, South Korea; 5Department of Dermatology, Korea University Medical School and College, Seoul, South Korea; 6Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University, Seoul, South Korea; 7Department of Food and Nutrition, College of Science and Engineering, Anyang University, Anyang, Gyeonggi, South Korea; 8Consumers Korea, Seoul, South Korea Purpose: This study examined the need for public communication about nanotechnologies and nanoparticles by providing a comparative analysis of the differences in risk awareness of nanotechnologies and nanoparticles between consumers and experts. Methods: A total of 1,007 consumers and 150 experts participated in this study. A questionnaire was prepared examining their awareness of nanotechnologies and nanomaterials and their view of the necessity for information and education about the latest nanotechnologies and nanomaterials. Results: Our results indicated that the expert group recognized that they knew more than consumers about nanotechnology and that there was a need for relevant education in nanotechnology and nanomaterials among consumers. We found that the consumer group had a more positive attitude toward nanotechnology, even though they did not know much about it. Moreover, the consumer group was inconclusive about the type of information on nanotechnology deemed necessary for the public, as well as the suitable party to be responsible for education

  16. Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

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    Kim CO

    2016-11-01

    Full Text Available Choon Ok Kim,1 Eun Sil Oh,2 Chungam Choi,1 Yeonjoo Kim,3 Sera Lee,4 Semi Kim,4 Min Soo Park1,5 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Pharmaceutical Medicines and Regulatory Science, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, 3Chong Kun Dang Clinical Research, Chong Kun Dang Pharmaceutical Corp., 4Chong Kun Dang Research Institute, Chong Kun Dang Pharmaceutical Corp., 5Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea Abstract: CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. We investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of CKD-519 in healthy adult subjects. A randomized, double-blinded, placebo-controlled, single ascending dose study was performed. Eight healthy subjects were enrolled in each CKD-519 dose group (25, 50, 100, 200, or 400 mg and randomized to CKD-519 (n=6 or matching placebo (n=2. CKD-519 reached the maximum plasma concentration (Cmax at 5–6 h post-dose, and had a long terminal half-life ranging between 40–70 h. The area under the plasma concentration–time curve (AUC and Cmax increased with the dose, however, Cmax and AUC normalized by dose decreased with each incremental dose. CETP activity decreased with dose, and the maximum decrease (63%–83% was observed at 6–8 h post-dose. A sigmoid Emax model best described the relationship between CKD-519 plasma concentrations and CETP activity with an EC50 of 17.3 ng/mL. Overall, 11 adverse events (AEs were observed. All AEs were mild or moderate in intensity, and resolved without any complications. There were no clinically significant effects on blood pressure. In conclusion, single doses of CKD-519 up to 400 mg were well tolerated and showed potent

  17. Interactive survey of consumer awareness of nanotechnologies and nanoparticles in consumer products in South Korea

    Directory of Open Access Journals (Sweden)

    Kim YR

    2014-12-01

    Full Text Available Yu-Ri Kim,1 Eun Jeong Lee,1 Sung Ha Park,2 Hyo Jin Kwon,3 Seong Soo A An,4 Sang Wook Son,5 Young Rok Seo,6 Jae-Eun Pie,7 Myoung Yoon,8 Ja Hei Kim,8 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 2Department of Biochemistry, University of Bath, Bath, UK; 3Department of Medical Education, Korea University Medical School and College, Seoul, South Korea; 4Department of Bionanotechnology, Gachon University, Seongnam, South Korea; 5Department of Dermatology, Korea University Medical School and College, 6Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University, Seoul, South Korea; 7Department of Food and Nutrition, College of Science and Engineering, Anyang University, Anyang, Korea; 8Consumers Korea, Seoul, South Korea Background: The purpose of our study was to understand consumers' risk awareness and need for relevant information about nanotechnology and nanoparticles contained in products currently being sold in Korea. Methods: One thousand and seven adult consumers (aged 20–50 years were randomly selected from all over South Korea between November 1 and 9, 2010. We surveyed the origin and degree of their concern and their need for information and education regarding nanomaterials. Results: Analysis of the survey results showed no significant differences in responses by sex, age, and level of education, but significant differences were found in responses based on average monthly household income. Our research showed that consumers have vague expectations for and positive image of nanotechnology and nanoproducts but do not clearly understand what they are. In addition, we found that preparing and disseminating information to consumers is required in order to provide correct information about nanotechnology to the public. Conclusion: A communication system should be established among the multiple stakeholders involved

  18. NANOTECHNOLOGY, NANOMEDICINE; ETHICAL ASPECTS

    OpenAIRE

    G?K?AY, Banu; ARDA, Berna

    2015-01-01

    Nanotechnology is a field that we often hear of its name nowadays. Altough what we know about it is soo poor, we admire this field of technlogy, moreover some societies even argues that nanotechnology will cause second endustrial revolution. In addition, nanotechnology makes our basic scientific knowledge upside down and is soo powerfull that it is potent in nearly every scientific field. Thereby, it is imposible to say that nanotechnology; which is soo effective on human and human life; will...

  19. Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans

    Directory of Open Access Journals (Sweden)

    Min JS

    2016-09-01

    Full Text Available Jee Sun Min,1 Doyun Kim,1 Jung Bae Park,1 Hyunjin Heo,1 Soo Hyeon Bae,2 Jae Hong Seo,1 Euichaul Oh,1 Soo Kyung Bae1 1Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon, 2Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, South Korea Background: Evaluating the potential risk of metabolic drug–drug interactions (DDIs is clinically important. Objective: To develop a physiologically based pharmacokinetic (PBPK model for sarpogrelate hydrochloride and its active metabolite, (R,S-1-{2-[2-(3-methoxyphenylethyl]-phenoxy}-3-(dimethylamino-2-propanol (M-1, in order to predict DDIs between sarpogrelate and the clinically relevant cytochrome P450 (CYP 2D6 substrates, metoprolol, desipramine, dextromethorphan, imipramine, and tolterodine. Methods: The PBPK model was developed, incorporating the physicochemical and pharmacokinetic properties of sarpogrelate hydrochloride, and M-1 based on the findings from in vitro and in vivo studies. Subsequently, the model was verified by comparing the predicted concentration-time profiles and pharmacokinetic parameters of sarpogrelate and M-1 to the observed clinical data. Finally, the verified model was used to simulate clinical DDIs between sarpogrelate hydrochloride and sensitive CYP2D6 substrates. The predictive performance of the model was assessed by comparing predicted results to observed data after coadministering sarpogrelate hydrochloride and metoprolol. Results: The developed PBPK model accurately predicted sarpogrelate and M-1 plasma concentration profiles after single or multiple doses of sarpogrelate hydrochloride. The simulated ratios of area under the curve and maximum plasma concentration of metoprolol in the presence of sarpogrelate hydrochloride to baseline were in good agreement with the observed ratios. The predicted fold-increases in the area under the curve ratios of metoprolol

  20. Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

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    Han S

    2015-09-01

    Full Text Available Seunghoon Han,1,2 Sangil Jeon,1,2 Taegon Hong,1,2 Jongtae Lee,1,2 Soo Hyeon Bae,1,2 Wan-su Park,1,2 Gab-jin Park,1,2 Sunil Youn,1,2 Doo Yeon Jang,1,2 Kyung-Soo Kim,3 Dong-Seok Yim1,2 1Department of Pharmacology, College of Medicine, The Catholic University of Korea, 2Pharmacometrics Institute for Practical Education and Training, 3Department of Family Medicine, Seoul St Mary’s Hospital, Seochogu, Seoul, Republic of KoreaAbstract: No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure–response model of sibutramine mesylate that can be applied during clinical development of other weight-control drugs. Additionally, we provide a model-based evaluation of sibutramine efficacy. Data from a double-blind, randomized, placebo-controlled, multicenter study were used (N=120. Subjects in the treatment arm were initially given 8.37 mg sibutramine base daily, and those who lost <2 kg after 4 weeks’ treatment were escalated to 12.55 mg. The duration of treatment was 24 weeks. Drug concentration and body weight were measured predose and at 4 weeks, 8 weeks, and 24 weeks after treatment initiation. Exposure and response to sibutramine, including the placebo effect, were modeled using NONMEM 7.2. An asymptotic model approaching the final body weight was chosen to describe the time course of weight loss. Extent of weight loss was described successfully using a sigmoidal exposure–response relationship of the drug with a constant placebo effect in each individual. The placebo effect was influenced by subjects’ sex and baseline body mass index. Maximal weight loss was predicted to occur around 1 year after treatment initiation. The difference in mean weight loss between the sibutramine (daily 12.55 mg and placebo groups was predicted to be 4.5% in a simulation of 1 year of treatment, with considerable overlap of prediction intervals. Our exposure–response model, which

  1. Review: Margaret A. Morrison, Eric Haley, Kim Bartel Sheehan & Ronal E. Taylor (2002. Using Qualitative Research in Advertising: Strategies, Techniques, and Applications / Shay Sayre (2001. Qualitative Methods for Marketplace Research

    Directory of Open Access Journals (Sweden)

    Susanne Friese

    2004-01-01

    Full Text Available The review discusses two books, both covering very similar contents and addressing more or less the same audience. The book by SAYRE is about the use of qualitative method in marketplace research in general and is aimed at marketing students and practitioners; the book by MORRISON, HALEY, SHEEHAN and TAYLOR focuses more specifically on one area of mar­keting, namely advertising research. MORRISON et al. provide the more practical perspective, a fact that is also reflected in the writing style of the book. It is stimulating to read, even for readers fa­miliar with qualitative methods. It provides insights from the perspective of advertising agency plan­ners and demonstrates how qualitative methods are applied in a commercial context. SAYRE, in comparison, provides more details and builds her book around five theoretical perspectives. It is writ­ten by an academic for a largely academic audi­ence, containing all the basics that one needs to know when embarking on a qualitative research project. It differs from other qualitative method books in that the various steps along the way are illustrated by examples from the field of marketing. The book will, therefore, resonate well with mar­ket­ing students. Nonetheless, both books can be recommended as text books for qualitative method courses in marketing—SAYRE's book for market­ing students in general, and MORRISON et al.'s book for students specializing in the field of adver­tising. When used in a course where students conduct a small scale research project on their own, both books need to be supplemented by further readings or teacher input. Specifically, the sections on qualitative data analysis are too thin in MORRISON et al. and too broad in SAYRE in order to be useful to students without further explanation and training. Nonetheless, the two books are the best I have seen so far when it comes to selecting a book to be used in a qualitative method course for marketing students. URN: urn:nbn:de:0114-fqs0401258

  2. Comment on "Combination of cupric ion with hydroxylamine and hydrogen peroxide for the control of bacterial biofilms on RO membranes by Hye-Jin Lee, Hyung-Eun Kim, Changha Lee [Water Research 110, 2017, 83-90]".

    Science.gov (United States)

    Chen, Long; Peng, Ying; Tang, Min; Wu, Feng

    2017-07-01

    The methodology employed by Lee et al. to terminate their bactericidal assays was found to be flawed via our demonstrations. Briefly, EDTA or sulfite combining with cupric ion did not fully terminate, and instead even boosted the P. aeruginosa death. We therefore suggested them to seek for other means of reaction termination, such as the combination of buffering agent PBS and Cu(II)-complexing agent EDTA. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Oral vaccination with LcrV from Yersinia pestis KIM delivered by live attenuated Salmonella enterica serovar Typhimurium elicits a protective immune response against challenge with Yersinia pseudotuberculosis and Yersinia enterocolitica.

    Science.gov (United States)

    Branger, Christine G; Torres-Escobar, Ascención; Sun, Wei; Perry, Robert; Fetherston, Jacqueline; Roland, Kenneth L; Curtiss, Roy

    2009-08-27

    The use of live recombinant attenuated Salmonella vaccines (RASV) synthesizing Yersinia proteins is a promising approach for controlling infection by Yersinia species. In this study, we constructed attenuated Salmonella strains which synthesize a truncated form of LcrV, LcrV196 and evaluated the immune response and protective efficacy elicited by these strains in mice against two other major species of Yersinia: Yersinia pseudotuberculosis and Yersinia enterocolitica. Surprisingly, we found that the RASV strain alone was sufficient to afford nearly full protection against challenge with Y. pseudotuberculosis, indicating the likelihood that Salmonella produces immunogenic cross-protective antigens. In contrast, lcrV196 expression was required for protection against challenge with Y. enterocolitica strain 8081, but was not sufficient to achieve significant protection against challenge with Y. enterocolitica strain WA, which expressed a divergent form of lcrV. Nevertheless, we are encouraged by these findings to continue pursuing our long-term goal of developing a single vaccine to protect against all three human pathogenic species of Yersinia.

  4. Exercise for frail elders Exercise for frail elders Best-Martini Elizabeth Kim A Product Botenhagen-Di Genova Human Kinetics £24.50 0 73603 687 3 0736036873.

    Science.gov (United States)

    2003-09-01

    Department of Health Publications Free 208 pp This guide provides practical advice on how to obtain information, services and equipment. It is aimed at people who are older, disabled or who have mental health problems and those who support them. Copies are available in Braille, audio cassette, disk, large print and in a range of languages. Tel: 0800 555777. www.doh.gov.uk /disabledguide.

  5. Report on the KIMS-CNA Conference (2nd): The PLA Navy’s Build-Up and ROK-USN Cooperation, Held in Seoul, Korea on 20 November 2008

    Science.gov (United States)

    2009-02-01

    Kegan Paul International and The AEI Press, 1996), p. 274. See also his "China’s Push Through the South China Sea: The Interaction of Bureaucratic and...to " green /blue water" navy enable to secure its vast maritime territorial claims with modern combat capability. For long time, the Chinese navy...operational capability placed somewhat between "coastal defense" and "full ocean-going green water fleet." It is conceivable that the Chinese navy’s

  6. A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats

    Directory of Open Access Journals (Sweden)

    Park HS

    2014-12-01

    Full Text Available Hark-Soo Park,1 Seon-Ju Kim,1 Taek-Jin Lee,1 Geon-Yong Kim,1 EunHo Meang,1 Jeong-Sup Hong,1 Su-Hyon Kim,1 Sang-Bum Koh,1 Seung-Guk Hong,1 Yle-Shik Sun,1 Jin Seok Kang,2 Yu-Ri Kim,3 Meyoung-Kon Kim,3 Jayoung Jeong,4 Jong-Kwon Lee,4 Woo-Chan Son,5 Jae-Hak Park61General Toxicology Team, Korea Testing and Research Institute, Seoul, 2Department of Biomedical Laboratory Science, Namseoul University, Cheonan, 3Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, 4National Institute of Food and Drug Safety Evaluation, Seoul, 5Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 6Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, KoreaPurpose: The study reported here was conducted to determine the systemic oral toxicity and to find the no-observed-adverse-effect level of 20 nm positively charged zinc oxide (ZnOSM,20(+ nanoparticles in Sprague Dawley rats for 90 days.Methods: For the 90-day toxicity study, the high dose was set as 500 mg per kg of body weight (mg/kg and the middle and low dose were set to 250 mg/kg and 125 mg/kg, respectively. The rats were held for a 14-day recovery period after the last administration, to observe for the persistence or reduction of any toxic effects. A distributional study was also carried out for the systemic distribution of ZnOSM,20(+ NPs.Results: No rats died during the test period. There were no significant clinical changes due to the test article during the experimental period in functional assessment, body weight, food and water consumption, ophthalmological testing, urine analysis, necropsy findings, or organ weights, but salivation was observed immediately after administration in both sexes. The total red blood cell count was increased, and hematocrit, albumin, mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration were decreased significantly compared with

  7. Immunotoxicity of zinc oxide nanoparticles with different size and electrostatic charge

    Directory of Open Access Journals (Sweden)

    Kim CS

    2014-12-01

    Full Text Available Cheol-Su Kim,1,* Hai-Duong Nguyen,1,* Rosa Mistica Ignacio,2 Jae-Hyun Kim,1 Hyeon-Cheol Cho,1 Eun Ho Maeng,3 Yu-Ri Kim,4 Meyoung-Kon Kim,4 Bae-Keun Park,5 Soo-Ki Kim1,5 1Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju-si, Gangwon-do, Republic of Korea; 2Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju-si, Gangwon-do, Republic of Korea; 3Healthcare Laboratory, Medical Device Evaluation Team, Korea Testing and Research Institute, Gimpo-si, Gyeonggi-do, Republic of Korea; 4Department of Biochemistry and Molecular Biology, Medical School and College, Korea University, Seoul, Republic of Korea; 5Institute of Lifestyle Medicine, Wonju College of Medicine, Yonsei University, Wonju-si, Gangwon-do, Republic of Korea *These authors contributed equally to this work Abstract: While zinc oxide (ZnO nanoparticles (NPs have been recognized to have promising applications in biomedicine, their immunotoxicity has been inconsistent and even contradictory. To address this issue, we investigated whether ZnO NPs with different size (20 or 100 nm and electrostatic charge (positive or negative would cause immunotoxicity in vitro and in vivo, and explored their underlying molecular mechanism. Using Raw 264.7 cell line, we examined the immunotoxicity mechanism of ZnO NPs as cell viability. We found that in a cell viability assay, ZnO NPs with different size and charge could induce differential cytotoxicity to Raw 264.7 cells. Specifically, the positively charged ZnO NPs exerted higher cytotoxicity than the negatively charged ones. Next, to gauge systemic immunotoxicity, we assessed immune responses of C57BL/6 mice after oral administration of 750 mg/kg/day dose of ZnO NPs for 2 weeks. In parallel, ZnO NPs did not alter the cell-mediated immune response in mice but suppressed innate immunity such as natural killer cell activity. The CD4+/CD8+ ratio, a marker for matured T-cells was slightly

  8. Dzhässimaal, avalik loomevabadus / Tui Hirv

    Index Scriptorium Estoniae

    Hirv, Tui, 1984-

    2008-01-01

    20. aprillil Tallinna Kunstihoones toimunud üritusest Dzhässimaal, kus improviseeris 20.04.2008 Estonian Guitar Octet koosseisus Jaak Sooäär, Paul Daniel, Robert Jürjendal, Tõnis Leemets, Virgo Sillamaa, Mart Soo, Kalle Tikas ja Tarvo Kaspar Toome. Samal ajal maalisid pilte noored kunstnikud Tallinna kunstikoolist, Sally stuudiost ja Pelgulinna kunstigümnaasiumist

  9. Factors that influence the selection of learning opportunities for ...

    African Journals Online (AJOL)

    Sekere knelpunte het egter opgeduik wat as temas beskryf is, naamlik: Bestuursknelpunte, Onderrigknelpunte. Wat betref ";bestuursknelpunte"; as tema is verskeie kategorieë soos werkslading, verpleegtekorte, en kommunikasie probleme geïdentifiseer. Die tema ";onderrigknelpunte"; het kategorieë soos 'n gebrek aan ...

  10. Kanna hy kô hystoe, Joanie Galant-hulle en

    African Journals Online (AJOL)

    Owner

    Vermeulen (3) beskryf dié agtergrond soos volg: “Kanna hy kô hystoe(1965) wortel, soos. Adam Small se ... ten opsigte van die titelkarakters in Van Wyk Louw se dramas Dias(1952) en Germanicus ...... tesis, U van Witwatersrand, 1984. Olivier ...

  11. Islandi-elamus

    Index Scriptorium Estoniae

    2008-01-01

    Galeriis SooSoo on müügil islandi noorte disainerite tööd: Gudrun Lilja Gunnlaugsdottiri laserlõiketehnoloogias raamaturiiulid "Fairytale", Ingibjörg Hanna Bjarnadottiri riidepuud "Raven", Tinna Gunnarsdottiri kummist laualinikud "Samurai", Katrin Olina riidenagid "Tree" ja portselannõud

  12. Die huwelik in die eerste-eeuse Mediterreense wêreld (I): Vroue in ...

    African Journals Online (AJOL)

    p1243322

    huwelikstrategie gekoppel aan sekere tydperke in die geskiedenis van Israel en die Jodedom. .... eeuse Mediterreense wêreld soos volg: “Unlike our Western guilt-focused society, the pivotal value of the ... soos volg: “[Honor] is recognized as the 'pivotal value' of the ancient Mediterranean world, and 'love of honor' ...

  13. Disainiöös / Kaija-Luisa Kurik

    Index Scriptorium Estoniae

    Kurik, Kaija-Luisa

    2008-01-01

    26.-28. sept. 2008 Tallinnas toimunud festivalist "Arts and Lights" ja disainiööst "Kummardus loovusele!". Anti üle disainiauhinnad Bruno tootedisaini kategoorias Mare Kelpmanile ning disainiprojekti kategoorias Tarmo Luisule. Islandi disaini näitusest Kultuurikatlas ja poola disaini näitusest SooSoo galeriis. Üritusest Pecha Kucha Night

  14. Pehkinud palkseintega luksusvilla / Jana Rand

    Index Scriptorium Estoniae

    Rand, Jana, 1963-

    2005-01-01

    Pädaste mõisa (omanikud Imre Sooäär ja Martin Breuer) 350-aastase moonakatemaja renoveerimine puhkemajaks. Nõu ümberehitamiseks andis soome disainer Ristomatti Ratia. Sisekujunduse autor Imre Sooäär, tema kommentaarid. 10 värv. ill

  15. EFFECTS OF MYCORRHIZAL FUNGI ON IN-VITRO NITROGEN RESPONSE OF SOME DUTCH INDIGENOUS ORCHID SPECIES

    NARCIS (Netherlands)

    DIJK, E; ECK, ND

    The effect of mycorrhizal infection on the response to mineral nitrogen was studied in Orchis morio L., Dactylorhiza praetermissa (Druce) Soo var. junialis (Vermin.) Sengh., Dactylorhiza majalis (Reichb.) Hunt & Summerh., and Dactylorhiza incarnara (L.) Soo, using two strains of Ceratorhiza sp. and

  16. Tase '08 - kui tase siis ikkagi? / Maarin Ektermann

    Index Scriptorium Estoniae

    Ektermann, Maarin

    2008-01-01

    Eesti Kunstiakadeemia lõputööde näitustest, mis toimuvad festivali "Tase '08" raames: vabade kunstide teaduskonna magistritööde väljapanekust Kumu Kunstimuuseumis; disainiteaduskonna lõputööde, mis valmisid koostöös IT Kolledzhi üliõpilastega, näitusest "Arukalt" "SooSoo" galeriis

  17. Clinical Feasibility of Continuously Monitored Data for Heart Rate, Physical Activity, and Sleeping by Wearable Activity Trackers in Patients with Thyrotoxicosis: Protocol for a Prospective Longitudinal Observational Study.

    Science.gov (United States)

    Lee, Jie-Eun; Lee, Dong Hwa; Oh, Tae Jung; Kim, Kyoung Min; Choi, Sung Hee; Lim, Soo; Park, Young Joo; Park, Do Joon; Jang, Hak Chul; Moon, Jae Hoon

    2018-02-21

    Thyrotoxicosis is a common disease caused by an excess of thyroid hormones. The prevalence of thyrotoxicosis about 2% and 70-90% of thyrotoxicosis cases are caused by Graves' disease, an autoimmune disease, which has a high recurrence rate when treated with antithyroid drugs such as methimazole or propylthiouracil. The clinical symptoms and signs of thyrotoxicosis include palpitation, weight loss, restlessness, and difficulty sleeping. Although these clinical changes in thyrotoxicosis can be detected by currently available wearable activity trackers, there have been few trials of the clinical application of wearable devices in patients with thyrotoxicosis. The aim of this study is to investigate the clinical applicability of wearable device-generated data to the management of thyrotoxicosis. We are analyzing continuously monitored data for heart rate, physical activity, and sleep in patients with thyrotoxicosis during their clinical course after treatment. Thirty thyrotoxic patients and 10 control subjects were enrolled in this study at Seoul National University Bundang Hospital. Heart rate, physical activity, and sleep are being monitored using a Fitbit Charge HR or Fitbit Charge 2. Clinical data including anthropometric measures, thyroid function test, and hyperthyroidism symptom scale are recorded. Study enrollment began in December 2016, and the intervention and follow-up phases are ongoing. The results of the data analysis are expected to be available by September 2017. This study will provide a foundational feasibility trial of the clinical applications of biosignal measurements to the differential diagnosis, prediction of clinical course, early detection of recurrence, and treatment in patients with thyrotoxicosis. ClinicalTrials.gov NCT03009357; https://clinicaltrials.gov/ct2/show/NCT03009357 (Archived by WebCite at http://www.webcitation.org/6wh4MWPm2). ©Jie-Eun Lee, Dong Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Sung Hee Choi, Soo Lim, Young Joo Park, Do

  18. Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation

    Directory of Open Access Journals (Sweden)

    Al-Amin M

    2016-12-01

    Full Text Available Md Al-Amin, Jiafu Cao, Muhammad Naeem, Hasanul Banna, Min-Soo Kim, Yunjin Jung, Hae Young Chung, Hyung Ryong Moon, Jin-Wook Yoo College of Pharmacy, Pusan National University, Busan, South Korea Abstract: Hyperpigmentation caused by melanin overproduction is a major skin disorder in humans. Inhibition of tyrosinase, a key regulator of melanin production, has been used as an effective strategy to treat hyperpigmentation. In this study, we investigated the use of solid lipid nanoparticles (SLNs as a highly effective and nontoxic means to deliver a newly synthesized potent tyrosinase inhibitor, MHY498, and to target melanocytes through the skin. MHY498-loaded SLNs (MHY-SLNs were prepared by an oil-in-water emulsion solvent-evaporation method, and their morphological and physicochemical properties were characterized. MHY-SLNs showed a prolonged drug-release profile and higher skin permeation than that of MHY solution. In an in vivo evaluation of antimelanogenic activity, MHY-SLNs showed a prominent inhibitory effect against ultraviolet B-induced melanogenesis, resulting in no change in the skin color of C57BL/6 mouse, compared with that observed in an MHY solution-treated group and an untreated control group. The antimelanogenic effect of MHY-SLNs was further confirmed through Fontana–Masson staining. Importantly, MHY-SLNs did not induce any toxic effects in the L929 cell line. Overall, these data indicate that MHY-SLNs show promise in the topical treatment of hyperpigmentation. Keywords: melanogenesis, hyperpigmentation, MHY498, solid lipid nanoparticles, skin delivery

  19. The genetics of Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Bagyinszky E

    2014-04-01

    Full Text Available Eva Bagyinszky,1 Young Chul Youn,2 Seong Soo A An,1,* SangYun Kim3,*1Department of BioNano Technology Gachon University, Gyeonggi-do, 2Department of Neurology, Chung-Ang University College of Medicine, Seoul, 3Department of Neurology, Seoul National University Budang Hospital, Gyeonggi-do, South Korea*These authors contributed equally to this workAbstract: Alzheimer's disease (AD is a complex and heterogeneous neurodegenerative disorder, classified as either early onset (under 65 years of age, or late onset (over 65 years of age. Three main genes are involved in early onset AD: amyloid precursor protein (APP, presenilin 1 (PSEN1, and presenilin 2 (PSEN2. The apolipoprotein E (APOE E4 allele has been found to be a main risk factor for late-onset Alzheimer's disease. Additionally, genome-wide association studies (GWASs have identified several genes that might be potential risk factors for AD, including clusterin (CLU, complement receptor 1 (CR1, phosphatidylinositol binding clathrin assembly protein (PICALM, and sortilin-related receptor (SORL1. Recent studies have discovered additional novel genes that might be involved in late-onset AD, such as triggering receptor expressed on myeloid cells 2 (TREM2 and cluster of differentiation 33 (CD33. Identification of new AD-related genes is important for better understanding of the pathomechanisms leading to neurodegeneration. Since the differential diagnoses of neurodegenerative disorders are difficult, especially in the early stages, genetic testing is essential for diagnostic processes. Next-generation sequencing studies have been successfully used for detecting mutations, monitoring the epigenetic changes, and analyzing transcriptomes. These studies may be a promising approach toward understanding the complete genetic mechanisms of diverse genetic disorders such as AD.Keywords: dementia, amyloid precursor protein, presenilin 1, presenilin 2, APOE, mutation, diagnosis, genetic testing

  20. Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system

    Directory of Open Access Journals (Sweden)

    Yeom DW

    2017-05-01

    Full Text Available Dong Woo Yeom,1,* Bo Ram Chae,2,* Ho Yong Son,1 Jin Han Kim,1 Jun Soo Chae,1 Seh Hyon Song,2 Dongho Oh,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2Daewon Pharm. Co., Ltd, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST, a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol® P. The amounts of SMEDDS and Poloxamer 407 were chosen as formulation variables for a 3-level factorial design. Further optimization was established by weighting different levels of importance on response variables for dissolution and total quantity, resulting in an optimal S-SMEDDS in large quantity (S-SMEDDS_LQ; 352 mg in total and S-SMEDDS in reduced quantity (S-SMEDDS_RQ; 144.6 mg in total. Good agreement was observed between predicted and experimental values for response variables. Consequently, compared with VST powder or suspension and SMEDDS, both S-SMEDDS_LQ and S-SMEDDS_RQ showed excellent in vitro dissolution and in vivo oral bioavailability in rats. The magnitude of dissolution and absorption-enhancing capacities using quantity-based comparisons was in the order S-SMEDDS_RQ > S-SMEDDS_LQ > SMEDDS > VST powder or suspension. Thus, we concluded that, in terms of developing an effective SMEDDS preparation with minimal total quantity, S-SMEDDS_RQ is a promising candidate. Keywords: valsartan, SMEDDS, supersaturation, factorial design, optimization, bio­availability 

  1. Analysis of zinc oxide nanoparticles binding proteins in rat blood and brain homogenate

    Directory of Open Access Journals (Sweden)

    Shim KH

    2014-12-01

    Full Text Available Kyu Hwan Shim,1 John Hulme,1 Eun Ho Maeng,2 Meyoung-Kon Kim,3 Seong Soo A An1 1Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Sungnam-si, Gyeonggi-do, South Korea; 2Department of Analysis, KTR, Kimpo, Gyeonggi-do, South Korea; 3Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea Abstract: Nanoparticles (NPs are currently used in chemical, cosmetic, pharmaceutical, and electronic products. Nevertheless, limited safety information is available for many NPs, especially in terms of their interactions with various binding proteins, leading to potential toxic effects. Zinc oxide (ZnO NPs are included in the formulation of new products, such as adhesives, batteries, ceramics, cosmetics, cement, glass, ointments, paints, pigments, and supplementary foods, resulting in increased human exposures to ZnO. Hence, we investigated the potential ZnO nanotoxic pathways by analyzing the adsorbed proteins, called protein corona, from blood and brain from four ZnO NPs, ZnOSM20(-, ZnOSM20(+, ZnOAE100(-, and ZnOAE100(+, in order to understand their potential mechanisms in vivo. Through this study, liquid chromatography–mass spectroscopy/mass spectroscopy technology was employed to identify all bound proteins. Totals of 52 and 58 plasma proteins were identified as being bound to ZnOSM20(- and ZnOSM20(+, respectively. For ZnOAE100(- and ZnOAE100(+, 58 and 44 proteins were bound, respectively. Similar numbers of proteins were adsorbed onto ZnO irrespective of size or surface charge of the nanoparticle. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Interactions between diverse proteins and ZnO nanoparticles could result in an alteration of their functions, conformation, and clearance, eventually affecting many biological processes. Keywords: brain

  2. Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration

    Directory of Open Access Journals (Sweden)

    La WG

    2014-05-01

    Full Text Available Wan-Geun La,1 Min Jin,1 Saibom Park,1,2 Hee-Hun Yoon,1 Gun-Jae Jeong,1 Suk Ho Bhang,1 Hoyoung Park,1,2 Kookheon Char,1,2 Byung-Soo Kim1,31School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea; 2The National Creative Research Initiative Center for Intelligent Hybrids, Seoul National University, Seoul, Republic of Korea; 3Institute of Bioengineering, Institute of Chemical Processes, Engineering Research Institute, Seoul National University, Seoul, Republic of KoreaAbstract: In this study, we demonstrate that graphene oxide (GO can be used for the delivery of bone morphogenetic protein-2 (BMP-2 and substance P (SP, and that this delivery promotes bone formation on titanium (Ti implants that are coated with GO. GO coating on Ti substrate enabled a sustained release of BMP-2. BMP-2 delivery using GO-coated Ti exhibited a higher alkaline phosphatase activity in bone-forming cells in vitro compared with bare Ti. SP, which is known to recruit mesenchymal stem cells (MSCs, was co-delivered using Ti or GO-coated Ti to further promote bone formation. SP induced the migration of MSCs in vitro. The dual delivery of BMP-2 and SP using GO-coated Ti showed the greatest new bone formation on Ti implanted in the mouse calvaria compared with other groups. This approach may be useful to improve osteointegration of Ti in dental or orthopedic implants.Keywords: bone morphogenetic protein-2, bone regeneration, graphene oxides, stem cell recruitment, substance P

  3. The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease

    Directory of Open Access Journals (Sweden)

    Kim YW

    2015-05-01

    Full Text Available Yeon Wook Kim,1 Kwang-Nam Jin,2 Eun Young Heo,3 Sung Soo Park,3 Hee Soon Chung,3 Deog Kyeom Kim31Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; 2Department of Radiology, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of KoreaBackground: Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD, a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway inflammatory disease. This study evaluated the association between bronchiectasis and lung cancer in patients with COPD.Methods: A matched case–control study was conducted in a referral hospital in South Korea. Among COPD patients with moderate to very severe airflow limitation (forced expiratory volume in one second/forced vital capacity <0.7 and forced expiratory volume in one second ≤70% [% predicted] who underwent chest computed tomography (CT between January 1, 2010 and May 30, 2013, patients with lung cancer and controls matched for age, sex, and smoking history were selected. The risk of lung cancer was assessed according to the presence of underlying bronchiectasis confirmed by chest CT.Results: The study enrolled 99 cases and 198 controls. Combined bronchiectasis on chest CT was inversely associated with the risk of lung cancer compared with controls (odds ratio [OR] 0.25, 95% confidence interval [CI] 0.12–0.52, P<0.001. Significant associations were found in

  4. PSEN1 L226F mutation in a patient with early-onset Alzheimer’s disease in Korea

    Directory of Open Access Journals (Sweden)

    Bagyinszky E

    2016-10-01

    Full Text Available Eva Bagyinszky,1,* Sun Ah Park,2,* Hyung Jun Kim,2 Seong Hye Choi,3 Seong Soo A An,1 SangYun Kim4 1Department of BioNano Technology, Gachon University, Seongnam-si, 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, 3Department of Neurology, Inha University School of Medicine, Incheon, 4Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea *These authors contributed equally to this work Abstract: In this study, we report a first 226leucine (Leu mutation to phenylalanine (Phe in (PSEN1, CTC>TTC, L226F in Asia from a Korean early-onset Alzheimer’s disease (EOAD patient. Polymerase chain reaction (PCR–single strand conformation polymorphism, sequencing, and in silico predictions were performed. Previously, L226F was reported in EOAD patients by Zekanowski et al and Gómez-Tortosa et al. Disease phenotypes appeared in their thirties, and family history was positive in both cases. In our patient, age of onset was similar (37 years of age, but the mutation seemed to be de novo, since no affected family member was found. This leucine to phenylalanine substitution may cause additional stresses inside the transmembrane region due to large aromatic side chain and increased hydrophobic interactions with hydrocarbon chains in the membrane and its binding partners. Clinical phenotype of the mutation was aggressive progression into neurodegeneration, resulting in rapid cognitive decline. One of the patients was initially diagnosed with frontotemporal dementia, but the diagnosis was revised to AD upon postmortem studies in which Aβ plaques were seen. A second mutation, L226R, was found for the L226 residue. Similar to L226F, the patient with L226R also developed the first symptoms in his 30s, but EOAD was diagnosed in his 40s. These findings suggested that L226 might be an important residue in PSEN1

  5. Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation

    Directory of Open Access Journals (Sweden)

    Yoon TH

    2012-03-01

    Full Text Available Ki-Chun Yoo1, Chang-Hwan Yoon1, Dongwook Kwon2, Kyung-Hwan Hyun1, Soo Jung Woo1, Rae-Kwon Kim1, Eun-Jung Lim1, Yongjoon Suh1, Min-Jung Kim1, Tae Hyun Yoon2, Su-Jae Lee11Laboratory of Molecular Biochemistry, 2Laboratory of Nanoscale Characterization and Environmental Chemistry, Department of Chemistry, Hanyang University, Seoul, Republic of KoreaBackground: Titanium dioxide (TiO2 has been widely used in many areas, including biomedicine, cosmetics, and environmental engineering. Recently, it has become evident that some TiO2 particles have a considerable cytotoxic effect in normal human cells. However, the molecular basis for the cytotoxicity of TiO2 has yet to be defined.Methods and results: In this study, we demonstrated that combined treatment with TiO2 nanoparticles sized less than 100 nm and ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-dependent upregulation of Fas and conformational activation of Bax in normal human cells. Treatment with P25 TiO2 nanoparticles with a hydrodynamic size distribution centered around 70 nm (TiO2P25–70 together with ultraviolet A irradiation-induced caspase-dependent apoptotic cell death, accompanied by transcriptional upregulation of the death receptor, Fas, and conformational activation of Bax. In line with these results, knockdown of either Fas or Bax with specific siRNA significantly inhibited TiO2-induced apoptotic cell death. Moreover, inhibition of reactive oxygen species with an antioxidant, N-acetyl-L-cysteine, clearly suppressed upregulation of Fas, conformational activation of Bax, and subsequent apoptotic cell death in response to combination treatment using TiO2P25–70 and ultraviolet A irradiation.Conclusion: These results indicate that sub-100 nm sized TiO2 treatment under ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-mediated upregulation of the death receptor, Fas, and activation of the preapoptotic protein

  6. Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?

    Directory of Open Access Journals (Sweden)

    Kim CO

    2017-02-01

    Full Text Available Choon Ok Kim,1 Eun Sil Oh,2 Hohyun Kim,3 Min Soo Park1,4 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Pharmaceutical Medicine and Regulatory Sciences, College of Medicine and Pharmacy, Yonsei University, Incheon, 3Korea Medicine Research Institute, Inc., Seongnam, 4Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea Abstract: To improve cardiovascular outcomes, dyslipidemia in patients with diabetes needs to be treated. Thus, these patients are likely to take glimepiride and rosuvastatin concomitantly. Therefore, this study aimed to evaluate the pharmacokinetic (PK interactions between these two drugs in healthy males and to explore the effect of SLCO1B1 and CYP2C9 polymorphisms on their interactions in two randomized, open-label crossover studies. Glimepiride was studied in part 1 and rosuvastatin in part 2. Twenty-four participants were randomly assigned to each part. All subjects (n=24 completed part 1, and 22 subjects completed part 2. A total of 38 subjects among the participants of the PK interaction studies were enrolled in the genotype study to analyze their SLCO1B1 and CYP2C9 polymorphisms retrospectively (n=22 in part 1, n=16 in part 2. Comparison of the PK and safety of each drug alone with those of the drugs in combination showed that both glimepiride and rosuvastatin did not interact with each other and had tolerable safety profiles in all subjects. However, with regard to glimepiride PK, the SLCO1B1 521TC group had a significantly higher maximum plasma concentration (Cmax,ss and area under the plasma concentration–time curve during the dose interval at steady state (AUCt,ss for glimepiride in combination with rosuvastatin than those for glimepiride alone. However, other significant effects of the SLCO1B1 or CYP2C9 polymorphism on the interaction between the two drugs were not observed. In conclusion, there were no significant PK

  7. A Study of China’s Possible Military Intervention in the Event of a Sudden Change in North Korea

    Science.gov (United States)

    2011-06-10

    Kim Jong - nam , Kim Jong -chul or Kim Jong -un as Kim‘s successor. Some have asserted that there might not be a third generation of Kim ...The power struggle between Kim Jong - nam (eldest son) who is residing in China and Kim Jong -un has been observed in many places over time. Kim 29... Jong - nam , who is known to be receiving Chinese support, revealed his opposition to a third generation of dynastic succession in

  8. Effect of self-assembled peptide–mesenchymal stem cell complex on the progression of osteoarthritis in a rat model

    Directory of Open Access Journals (Sweden)

    Kim JE

    2014-05-01

    Full Text Available Ji Eun Kim,1 Sang Mok Lee,2 Soo Hyun Kim,1 Phil Tatman,3 Albert O Gee,4 Deok-Ho Kim,3,5 Kyung Eun Lee,6 Youngmee Jung,1 Sang Jun Kim21Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, South Korea; 2Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Seoul, South Korea; 3Department of Bioengineering, 4Department of Orthopaedics and Sports Medicine, 5Institute for Stem Cell and Regenerative Medicine and Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA; 6Advanced Analysis Center, Korea Institute of Science and Technology, Seoul, South KoreaPurpose: To evaluate the efficacy of mesenchymal stem cells (MSCs encapsulated in self-assembled peptide (SAP hydrogels in a rat knee model for the prevention of osteoarthritis (OA progression.Materials and methods: Nanostructured KLD-12 SAPs were used as the injectable hydrogels. Thirty-three Sprague Dawley rats were used for the OA model. Ten rats were used for the evaluation of biotin-tagged SAP disappearance. Twenty-three rats were divided into four groups: MSC (n=6, SAP (n=6, SAP-MSC (n=6, and no treatment (n=5. MSCs, SAPs, and SAP-MSCs were injected into the knee joints 3 weeks postsurgery. Histologic examination, immunofluorescent staining, measurement of cytokine levels, and micro-computed tomography analysis were conducted 6 weeks after injections. Behavioral studies were done to establish baseline measurements before treatment, and repeated 3 and 6 weeks after treatment to measure the efficacy of SAP-MSCs.Results: Concentration of biotinylated SAP at week 1 was not significantly different from those at week 3 and week 6 (P=0.565. Bone mineral density was significantly lower in SAP-MSC groups than controls (P=0.002. Significant differences in terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling staining between the control group and all other groups were observed. Caspase-8, tissue inhibitor of

  9. A genetic screen of the mutations in the Korean patients with early-onset Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    An SS

    2016-12-01

    Full Text Available Seong Soo An,1,* Sun Ah Park,2,* Eva Bagyinszky,1 Sun Oh Bae,1 Yoon-Jeong Kim,2 Ji Young Im,2 Kyung Won Park,3 Kee Hyung Park,4 Eun-Joo Kim,5 Jee Hyang Jeong,6 Jong Hun Kim,7 Hyun Jeong Han,8 Seong Hye Choi,9 SangYun Kim10 1Department of Bionano Technology, Gachon University, Seongnam-si, 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, 3Department of Neurology, Dong-A University College of Medicine and Institute of Convergence Bio-Health, Busan, 4Department of Neurology, Gachon University Gil Medical Center, Incheon, 5Department of Neurology, Pusan National University Hospital, Busan, 6Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, 7Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, 8Department of Neurology, Myongii Hospital, Goyang, 9Department of Neurology, Inha University School of Medicine, Incheon, 10Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea *These authors contributed equally to this work Abstract: Early-onset Alzheimer’s disease (EOAD has distinct clinical characteristics in comparison to late-onset Alzheimer’s disease (LOAD. The genetic contribution is suggested to be more potent in EOAD. However, the frequency of causative mutations in EOAD could be variable depending on studies. Moreover, no mutation screening study has been performed yet employing large population in Korea. Previously, we reported that the rate of family history of dementia in EOAD patients was 18.7% in a nationwide hospital-based cohort study, the Clinical Research Center for Dementia of South Korea (CREDOS study. This rate is much lower than in other countries and is even comparable to the frequency of LOAD patients in our country. To understand the genetic characteristics of EOAD in Korea, we screened the common Alzheimer’s disease (AD

  10. Yerli ve Yabancı Kökenli Bazı Zeytinyağlarının Trigliserit Düzeylerine Göre Kemometrik Sınıflandırılması

    Directory of Open Access Journals (Sweden)

    Harun Dıraman

    2015-02-01

    Full Text Available Bu çalışmada Türkiye’den (2 KKTC, 2 Güneydoğu Anadolu, 3 Akdeniz, 9 Kuzey Ege, 3 İzmir Yarımdası, 16 Güney Ege, 11 Akhisar-Manisa, 4 Marmara ve diğer ülkelerden (1 Ürdün, 1 Filistin, 3 İspanya,1 Portekiz, 2 İtalya, 2 Yunanistan olmak üzere toplam 60 adet ticari natürel zeytinyağı örneği, kemometrik yöntemler (Temel Bileşenler [PCA] Kümeleme [HCA] analizleri yardımıyla triaçilgliserol (TAG bileşenlerine göre sınıflandırılmış ve karakterize edilmişlerdir. Yağ örneklerinin TAG profilleri (ECN 42–ECN 50,LLL ve ana bileşenleri LOO, OOO, POO, PLO ve SOO Avrupa Komisyonu (ABK tarafından onaylanmış Yüksek Basınç Sıvı Kromatografisi ile belirlenmiştir. Türk natürel zeytinyağlarının TAG bileşenlerinin diğer zeytinyağı üreten ülkelerin ürünleri ile benzer olduğu ve bir örnek hariç (Filistin analiz edilen tüm yağ örneklerindeki trilinolein (LLL düzeylerinin, ABK tarafından farklı zeytinyağları için verilen en çok %0.5 düzeyini aşmadığı görülmüştür. Kümeleme analizi (HCA sonuçlarına göre, Türk ve yabancı zeytinyağı örnekleri sırasıyla beş gruba ayrılmıştır. Temel bileşenler analizine (PCA göre, Güney Ege (hâkim çeşit Memecik yağ örneklerinin sınıflandırılmasında LOO/POO, OOO/POO ve OOO düzeylerinin sorumlu olduğu gözlenmiştir. Kuzey Ege (hâkim çeşit Ayvalık örneklerinin ayrımında LOO parametresi büyük rol oynamıştır. Akhisar–Manisa yöresi örnekleri ise ECN48 ve ECN48/ECN46 parametreleri ile karakterize olmuştur. Bu çalışmada Türkiye’den (2 KKTC, 2 Güneydoğu Anadolu, 3 Akdeniz, 9 Kuzey Ege, 3 İzmir Yarımdası, 16 Güney Ege, 11 Akhisar-Manisa, 4 Marmara ve diğer ülkelerden (1 Ürdün, 1 Filistin, 3 İspanya,1 Portekiz, 2 İtalya, 2 Yunanistan olmak üzere toplam 60 adet ticari natürel zeytinyağı örneği, kemometrik yöntemler (Temel Bileşenler [PCA] Kümeleme [HCA] analizleri yardımıyla tria

  11. Uudised

    Index Scriptorium Estoniae

    2007-01-01

    Kalev Saare näitus "Portfolio" Võru Linnagaleriis kuni 2. III. Arhitektuurinäitused "Praha kubism" ja Jozhe Plechnik" Eesti Arhitektuurimuuseumis 03.-04. 2007. Tallinnas Soo 4 avatud kunsti- ja sisustusgaleriist SooSoo (galeristid Kadi Kõpper, Ülle Jehe), kus avanäitusena on kuni 17. III väljas Martin Pedaniku graafikaseeria "Kizoo". Hando Tamme maalinäitus "Meie aja kangelased vol 2" Jõhvi Kunstikooli galeriis 5.-31. III. Kunstiteaduste Instituudi Talvefoorum 007 ja muusikaürituste sari Müsteerium 3.-4. III Juurus. Loetletud "Kujundite taaskasutusel" esinejaid

  12. The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices

    Directory of Open Access Journals (Sweden)

    Lee JA

    2015-03-01

    Full Text Available Jeong-A Lee,1,* Mi-Kyung Kim,1,* Hyoung-Mi Kim,2,* Jong Kwon Lee,3 Jayoung Jeong,4 Young-Rok Kim,5 Jae-Min Oh,2 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Republic of Korea; 3Hazard Substances Analysis Division, Gwangju Regional Food and Drug Administration, Ministry of Food and Drug Safety, Gwangju, Republic of Korea; 4Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungcheongbuk-do, Republic of Korea; 5Department of Food Science and Biotechnology, Kyung Hee University, Yongin, Republic of Korea *These authors contributed equally to this work Background: Orally administered particles rapidly interact with biological fluids containing proteins, enzymes, electrolytes, and other biomolecules to eventually form particles covered by a corona, and this corona potentially affects particle uptake, fate, absorption, distribution, and elimination in vivo. This study explored relationships between the biological interactions of calcium carbonate particles and their biokinetics.Methods: We examined the effects of food grade calcium carbonates of different particle size (nano [N-Cal] and bulk [B-Cal]: specific surface areas of 15.8 and 0.83 m2/g, respectively on biological interactions in in vitro simulated physiological fluids, ex vivo biofluids, and in vivo in gastrointestinal fluid. Moreover, absorption and tissue distribution of calcium carbonates were evaluated following a single dose oral administration to rats.Results: N-Cal interacted more with biomatrices than bulk materials in vitro and ex vivo, as evidenced by high fluorescence quenching ratios, but it did not interact more actively with biomatrices in vivo. Analysis of coronas revealed that immunoglobulin, apolipoprotein, thrombin, and fibrinogen

  13. Organization of research team for nano-associated safety assessment in effort to study nanotoxicology of zinc oxide and silica nanoparticles

    Directory of Open Access Journals (Sweden)

    Kim YR

    2014-12-01

    Full Text Available Yu-Ri Kim,1,* Sung Ha Park,2,* Jong-Kwon Lee,3 Jayoung Jeong,3 Ja Hei Kim,4 Eun-Ho Meang,5 Tae Hyun Yoon,6 Seok Tae Lim,7 Jae-Min Oh,8 Seong Soo A An,9 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 2Department of Biochemistry, University of Bath, Bath, UK; 3Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk-do, 4Consumers Korea, Chongro-ku, 5General toxicology team, Korea Testing and Research Institute, 6Laboratory of Nanoscale Characterization and Environmental Chemistry, Department of Chemistry, College of Natural Sciences, Hanyang University, Seoul, 7Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Jellabuk-Do, 8Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Gangwon-do, 9Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, South Korea *Authors contributed equally to this work Abstract: Currently, products made with nanomaterials are used widely, especially in biology, biotechnologies, and medical areas. However, limited investigations on potential toxicities of nanomaterials are available. Hence, diverse and systemic toxicological data with new methods for nanomaterials are needed. In order to investigate the nanotoxicology of nanoparticles (NPs, the Research Team for Nano-Associated Safety Assessment (RT-NASA was organized in three parts and launched. Each part focused on different contents of research directions: investigators in part I were responsible for the efficient management and international cooperation on nano-safety studies; investigators in part II performed the toxicity evaluations on target organs such as assessment of genotoxicity, immunotoxicity, or skin penetration; and investigators in part III evaluated the toxicokinetics of NPs with newly developed

  14. Urologic symptoms and burden of frailty and geriatric conditions in older men: the Aging Study of PyeongChang Rural Area

    Directory of Open Access Journals (Sweden)

    Jang IY

    2018-02-01

    Full Text Available Il-Young Jang,1,2 Chang Ki Lee,3 Hee-Won Jung,4,5 Sang Soo Yu,2 Young Soo Lee,1 Eunju Lee,1 Dae Hyun Kim6,7 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 2PyeongChang Health Center & County Hospital, PyeongChang, Gangwon-Do, Republic of Korea; 3Goldman Urology Clinic, Seoul, Republic of Korea; 4Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST, Daejeon, Republic of Korea; 5Geriatric Center, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-Do, Republic of Korea; 6Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; 7Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA Purpose: Frailty is an important consideration in the management of lower urinary tract symptoms and erectile dysfunction in older men; frailty increases vulnerability to treatment-related adverse outcomes, but its burden is not known. The authors aimed to examine the burden of frailty and associated geriatric conditions in community-dwelling older men.Patients and methods: A cross-sectional study was conducted with 492 community-dwelling older men (mean age, 74.2 years; standard deviation, 5.6 years. All the participants were administered the International Prostate Symptom Score (IPSS (range: 0–35 and a five-item version of the International Index of Erectile Function (IIEF-5 (range: 5–25. Frailty phenotype was assessed based on exhaustion, inactivity, slowness, weakness, and weight loss. Prevalence of frailty phenotype and geriatric conditions were assessed by the IPSS severity category (mild, 0–7; moderate, 8–19; severe, 20–35 points and the first IIEF-5 question, which assesses the confidence in erectile function (low, 1–2; moderate, 3; high, 4–5 points.Results: Older men with severe urologic

  15. Kuula. Kuu artist Sam Sparro. Kuu plaat / Mart Juur

    Index Scriptorium Estoniae

    Juur, Mart, 1964-

    2008-01-01

    Artistist Sam Sparrost. Heliplaatidest: "Sex And The City" Original Motion Picture Soundtrack, "Maestro: Blue Note Trip", Melvin/Soo/Remmel/Julm "Geografix", Alanis Morrisette "Flavors Of Entanglement", Guillemots "Red"

  16. Investor Laaril esimene miljon teenitud / Kertu Ruus, Raivo Sormunen

    Index Scriptorium Estoniae

    Ruus, Kertu, 1977-

    2007-01-01

    Mart Laar, Imre Sooäär ja Kristen Michal oma aktsiaportfellist ja investeerimisstrateegiast. Edetabel: Riigikogus kolm miljonärist väikeinvestorit. Tabel: Ekspeaminister Laar on investeerinud erinevatesse piirkondadesse. Kommenteerivad Peeter Luikmel ja Pertti Rahnel

  17. Plaadid / Kaur Garshnek, Mart Niineste, Tui Hirv...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Uutest heliplaatidest Tuule Kann/Jaak Sooäär "Õhtu ilu", The Mars Volta "The Bedlam In Goliath", Eva Dahlgren "Petroleum Och Tang", Lenny Kravitz "It's Time For A Love revolution", "Flyleaf ", New Project "Ultraviolent Light"

  18. 11 Resensie-artikel Stimie WEB 02.pmd

    African Journals Online (AJOL)

    Owner

    Keywords: Afrikaans oratorio, classical music, corporate entertainment. .... soos FNB, Morning Star Express Hotel, kykNET, Packed House Productions, .... of feeling which represents the character of the people who speak that language.

  19. Phillip Louw: Oxford Afrikaans-Engels / English-Afrikaans Skoolwoordeboek / School Dictionary

    Directory of Open Access Journals (Sweden)

    Anton F. Prinsloo

    2011-10-01

    Full Text Available Die Oxford Afrikaans–Engels/English–Afrikaans Skoolwoordeboek is as skoolwoor-deboek 'n puik hulpbron vir leerders. Dit is egter meer as net 'n woordeboek, soos wat 'n oorsig dadelik toon.

  20. Värske kõrvaga kuuldud uuest Eesti muusikast / Elo Masing

    Index Scriptorium Estoniae

    Masing, Elo

    2011-01-01

    Eksperimentaalset Eesti muusikat tutvustava heliplaadi "Estonian Music Now 2011 - Exploratory Music From Estonia" esitluskontserdist 31. oktoobril Londonis Cafe OTOs, kus esinesid duo Taavi Kerikmäe - Mart Soo, Taavo Remmel ning Free Tallinn Trio

  1. Traditsioonist ja uuendusest korea modernkunstis / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2005-01-01

    Souli galeriides ja muuseumides valitseb eeldatud kõrgtehnoloogilise kunsti asemel maalikunst. Pikemalt naiskunstnik Wook-kyung Choi (1940-1985) ja Jong-gu Lee näitustest ning soo- ja naisuuringute kongressist "Women's World 2005"

  2. "Improtest" kui "improbleem" / Tõnis Kahu

    Index Scriptorium Estoniae

    Kahu, Tõnis, 1962-

    2009-01-01

    Improvisatsioonilise muusika kontserdisarjast "Improtest", sarja hooaja avakontserdist, kus esines prantsuse kitarrist Jean-Francois Pauvros. "Improtesti" eestvedajad Taavi Kerikmäe ja Mart Soo vastavad küsimustele

  3. Production and characterization of pectinases obtained from ...

    African Journals Online (AJOL)

    Production and characterization of pectinases obtained from Aspergillus fumigatus in submerged fermentation system using pectin extracted from mango peels as carbon source. AL Ezugwu, SOO Eze, FC Chilaka, CU Anyanwu ...

  4. Vintage: suvaline eriline vastikult eklektiline rohujuure disain = Vintage: arbitrary and peculiar, obnoxiously eclectic grassroots design / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2013-01-01

    Sisearhitekt Priit Põldme vintage stiilist. Armastusväärse kujundusega kohvikutest Eestis. Pikemalt kohvikust "Boheem" (Kopli t. 18, sisearhitekt Maris Kerge), "Kukeke" (Telliskivi t.), baarist "Pudel" (Telliskivi loomelinnak, sisekujundus: Pink) ja "Tops" (Soo t.) Tallinnas

  5. Eesti 15-16 aastaste koolinoorte uimastitarbimine : 1995., 1999. ja 2003. aasta uurimuste võrdlus / Airi-Alina Allaste

    Index Scriptorium Estoniae

    Allaste, Airi-Alina, 1967-

    2004-01-01

    Rahvusvaheliste uurimuste ESPAD käigus koguti andmeid uimastite tarvitamisega seotud käitumise kohta koolinoorte hulgas; Joon.: uimastite tarvitamine soo ja õppekeele järgi, tubakaga katsetajad ja regulaarsed suitsetajad, kanepisuitsetajad

  6. Frees-jääksoode [looduslik] taimestumine / J. Paal, E. Leiner, T. Paal, T. Triisberg

    Index Scriptorium Estoniae

    2011-01-01

    Lui looduslikus soos levivad paljud taimed eelkõige vegetatiivselt, siis jääksoos, eriti kui see ei piirne loodusliku sooga, seda toimuda ei saa, seega jääb seemneline uuendumine peamiselt tuulekandeliseks

  7. pastorale begeleiding van die emosioneel verwonde tiener

    African Journals Online (AJOL)

    1 Met emosionele verwonding word verwys na die gevolge van aspekte soos verwerping ..... gevind dat getraumatiseerde kinders geneig is om hul onverwerkte trauma ..... The changing face of the South African family: single moms now the.

  8. AVA Muusika plaadistab loova mõtlemisega artiste

    Index Scriptorium Estoniae

    2004-01-01

    AVA Muusika tegevusest eesti alternatiivse uue muusika salvestamisel, esimesest heliplaadist duo Erdmann/Sooäär Dessert Time'i ühisest albumist "Peer Gynt & Other Stories", plaadi esitlusest 5. nov. Berliinis

  9. Debora Vaarandi kodumaa / Maie Kalda

    Index Scriptorium Estoniae

    Kalda, Maie, 1929-2013

    2007-01-01

    Debora Vaarandi luulest: "Põleva laotuse linn", "Kohav rand", "Talgud Lööne soos", "Selgel hommikul", "Nii ma näen Eestimaad", "Unistaja aknal" ja "Rannalageda leib", "Eesti mullad". Ka Põhjamaa-teemast

  10. Statistika = Statistics

    Index Scriptorium Estoniae

    2004-01-01

    Andmeid maksuameti töötajate jagunemisest hariduse, soo, staazhi, vanuse järgi; koolitused 2001-2003, koolitusel osalejate arv; füüsilise isiku tuludeklaratsioon; tulu- ja sotsiaalmaksu maksudeklaratsioon; käibedeklaratsioon

  11. Pandi ja Hanschmidti spaa sai EASilt 10 miljonit krooni / Ralf-Martin Soe

    Index Scriptorium Estoniae

    Soe, Ralf-Martin

    2007-01-01

    Ettevõtluse Arendamise Sihtasutus finantseeris 2006. aastal 10 miljoni krooniga Tallinki juhtfiguuride osalusega AS-i Heal uue spaa ehitust Haapsalus. Diagramm: Osalused AS-is Heal. Vt. samas: Kilgile ja Sooäärele samuti 10 miljonit

  12. Download this PDF file

    African Journals Online (AJOL)

    2009-08-03

    Aug 3, 2009 ... Leefwysesiektes soos obesiteit word verwaarloos in ontwikkelende lande weens die fokus op ..... the 25% attributable to infectious diseases (Bradshaw et al. .... UNESCO Institute for Statistics, 2008, Glossary: Pupil-teacher.

  13. Plaadid / Kaur Garshnek, Ave Randviir, Priit Pruul...[jt.

    Index Scriptorium Estoniae

    2007-01-01

    Uutest heliplaatidest Jaak Sooäär, Raul Vaigla, Tanel Ruben "No99 Jazzklubis", Black Strobe "Burn Your Own Church", The Quantic Soul Orchestra "Tropidelico", Uni "Kosmikud II", Bugge Wesseltoft "IM", Gabrielle "Always"

  14. A Different Kind of Web-Based Knowledge Management: The DTRA Acquisition ToolBook

    Science.gov (United States)

    2008-12-01

    Reimbursement Order MIPR: Military Interdepartmental Purchase Request PWS: Performance Work Statement SOO: Statement of Objectives SOW: Scope of Work Figure 1...Competitive BAA: Broad Agency Announcement IACRO: Inter-Agency Cost Reimbur ement Order MIPR: Military Interdepartmental Purchas Request PWS

  15. Adapting a historical dictionary for the modern online user: The case ...

    African Journals Online (AJOL)

    user

    accommodate new users and to bring the DSAEHist into the digital era (with regard to standard web and mobile ... digitale era. Soos met talle ander gedrukte woordeboeke wat omgeskakel word na elektroniese ...... marketing perspective.

  16. Pädaste mõis pakub nii uut kui vana! / Aale Kask

    Index Scriptorium Estoniae

    Kask, Aale

    2008-01-01

    Renoveeritud Pädaste mõisa peahoonest (1875). Omanikud Imre Sooäär ja Martin Breuer. Mõisaansambli restaureerimine toimus aastail 1996-2008. Restaureerimisarhitekt Katrin Etverk. Sisearhitektuur: Imre Sooäär, Kärt Kukkur. Restoranisaal kasvab üle talveaiaks. Kärt Kukkuri, Katrin Etverki ja Ülle Grishakovi kommentaarid. Värv. välisvaade, 14 sisevaadet

  17. Analysis of SiO2 nanoparticles binding proteins in rat blood and brain homogenate

    Directory of Open Access Journals (Sweden)

    Shim KH

    2014-12-01

    Full Text Available Kyu Hwan Shim,1 John Hulme,1 Eun Ho Maeng,2 Meyoung-Kon Kim,3 Seong Soo A An1 1Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Sungnam-si, 2Department of Analysis, KTR, Kimpo, Gyeonggi-do, 3Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea Abstract: A multitude of nanoparticles, such as titanium oxide (TiO2, zinc oxide, aluminum oxide, gold oxide, silver oxide, iron oxide, and silica oxide, are found in many chemical, cosmetic, pharmaceutical, and electronic products. Recently, SiO2 nanoparticles were shown to have an inert toxicity profile and no association with an irreversible toxicological change in animal models. Hence, exposure to SiO2 nanoparticles is on the increase. SiO2 nanoparticles are routinely used in numerous materials, from strengthening filler for concrete and other construction composites, to nontoxic platforms for biomedical application, such as drug delivery and theragnostics. On the other hand, recent in vitro experiments indicated that SiO2 nanoparticles were cytotoxic. Therefore, we investigated these nanoparticles to identify potentially toxic pathways by analyzing the adsorbed protein corona on the surface of SiO2 nanoparticles in the blood and brain of the rat. Four types of SiO2 nanoparticles were chosen for investigation, and the protein corona of each type was analyzed using liquid chromatography-tandem mass spectrometry technology. In total, 115 and 48 plasma proteins from the rat were identified as being bound to negatively charged 20 nm and 100 nm SiO2 nanoparticles, respectively, and 50 and 36 proteins were found for 20 nm and 100 nm arginine-coated SiO2 nanoparticles, respectively. Higher numbers of proteins were adsorbed onto the 20 nm sized SiO2 nanoparticles than onto the 100 nm sized nanoparticles regardless of charge. When proteins were compared between the two charges, higher numbers of proteins were

  18. Scoping Review of Dance for Adults With Fibromyalgia: What Do We Know About It?

    Science.gov (United States)

    Bidonde, Julia; Boden, Catherine; Kim, Soo; Busch, Angela J; Goes, Suelen M; Knight, Emily

    2018-05-10

    studies evaluated the safety or adverse events systematically which is a major weakness of the literature. There are few studies in the field of dance and fibromyalgia, suggesting research is in its infancy but slowly growing. They are of European and South American origin, focusing on female participants and a limited number of dance modes. Because the body of literature is small, of low quality and highly heterogeneous, we concluded that a systematic review of interventions on dance is not warranted at this time. ©Julia Bidonde, Catherine Boden, Soo Kim, Angela J Busch, Suelen M Goes, Emily Knight. Originally published in JMIR Rehabilitation and Assistive Technology (http://rehab.jmir.org), 10.05.2018.

  19. A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects

    Directory of Open Access Journals (Sweden)

    Jung JA

    2015-03-01

    Full Text Available Jin Ah Jung,1 Soo-Yun Lee,2 Jung-Ryul Kim,1 Jae-Wook Ko,1,2 Seong Bok Jang,3 Su Youn Nam,3 Wooseong Huh1,41Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, 2Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, 3Yuhan Research Institute, Yuhan Corporation, 4Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaPurpose: Valsartan, an angiotensin-receptor blocker, and rosuvastatin, a competitive inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are frequently coadministered to treat patients with hypertension and dyslipidemia. The study reported here sought to evaluate the pharmacokinetic and pharmacodynamic interactions between rosuvastatin and valsartan in healthy Korean subjects. Subjects and methods: Thirty healthy male Korean subjects were administered with rosuvastatin (20 mg/day, valsartan (160 mg/day, and both drugs concomitantly for 4 days in a randomized, open-label, multiple-dose, three-treatment, three-period crossover study. Plasma concentrations of rosuvastatin, N-desmethyl rosuvastatin, and valsartan were determined using validated high-performance liquid chromatography with tandem mass spectrometry. Lipid profiles and vital signs (systolic and diastolic blood pressure and pulse rate were measured for the pharmacodynamic assessment.Results: For rosuvastatin, the geometric mean ratios (90% confidence intervals [CIs] of coadministration to mono-administration were 0.8809 (0.7873-0.9857 for maximum plasma concentration at steady state and 0.9151 (0.8632-0.9701 for area under the concentration–time curve (AUC over a dosing interval at steady state. For valsartan, the geometric mean ratios (90% CIs of those were 0.9300 (0.7946-1.0884 and 1.0072 (0.8893-1.1406, respectively. There were no significant differences in the metabolic ratio of N

  20. Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

    Directory of Open Access Journals (Sweden)

    Jang K

    2017-03-01

    Full Text Available Kyungho Jang,1,2,* Min-Kyoung Kim,3,4,* Jaeseong Oh,1 SeungHwan Lee,1 Joo-Youn Cho,1 Kyung-Sang Yu,1 Tai Kiu Choi,3 Sang-Hyuk Lee,3,4 Kyoung Soo Lim4 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 2Center for Clinical Pharmacology and Biomedical Research Institute, Chonbuk National University Medical School, Jeonju, 3Department of Psychiatry, 4Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea *These authors contributed equally to this work Purpose: Oseltamivir is widely used in the treatment and prophylaxis of influenza A and B viral infections. It is ingested as an oral prodrug that is rapidly metabolized by carboxylesterase 1 (CES1 to its active form, oseltamivir carboxylate. Dexamethasone is also used in the treatment of acute respiratory distress syndrome, a severe complication of influenza; however, its influence on the pharmacokinetics (PK of oseltamivir is controversial. The aim of this study was to investigate the effects of coadministering oseltamivir and dexamethasone on the PK of oseltamivir in healthy volunteers. Methods: An open-label, two-period, one-sequence, multiple-dose study was conducted in 19 healthy male volunteers. Oseltamivir (75 mg was orally administered on Day 1 and Day 8, and dexamethasone (1.5 mg was administered once daily from Day 3 to Day 8. Serial blood and urine samples were collected for PK analysis of oseltamivir and oseltamivir carboxylate on Day 1 and Day 8. Oseltamivir and oseltamivir carboxylate concentrations in plasma and urine were determined using liquid chromatography–tandem mass spectrometry. Results: Area under the plasma concentration–time curve (AUC of oseltamivir and oseltamivir carboxylate decreased after dexamethasone treatment for 6 days. The geometric mean ratio (90% confidence interval of the metabolic ratio

  1. Identification of two novel mutations, PSEN1 E280K and PRNP G127S, in a Malaysian family

    Directory of Open Access Journals (Sweden)

    Ch’ng GS

    2015-09-01

    Full Text Available Gaik-Siew Ch’ng,1,* Seong Soo A An,2,* Sun Oh Bae,2 Eva Bagyinszky,2 SangYun Kim3,41Department of Genetics, Kuala Lumpur Hospital, Malaysia; 2Department of Bionano Technology, Gachon University, 3Department of Neurology, Seoul National University College of Medicine, 4Seoul National University Bundang Hospital, South Korea*These authors contributed equally to this workAbstract: Alzheimer’s disease (AD is the most common form of dementia, which can be categorized into two main forms: early onset AD and late onset AD. The genetic background of early onset AD is well understood, and three genes, the APP, PSEN1, and PSEN2 have been identified as causative genes. In the current study, we tested three siblings from Malaysia who were diagnosed with early onset dementia, as well as their available family members. The family history was positive as their deceased father was similarly affected. Patients were tested for mutations in APP, PSEN1, PSEN2, and PRNP. A novel variant, E280K, was discovered in exon 8 of PSEN1 in the three siblings. In silico analyses with SIFT, SNAP, and PolyPhen2 prediction tools and three-dimensional modeling were performed, and the results suggested that the mutation is probably a pathogenic variant. Two additional pathogenic mutations were previously been described for codon 280, E280A, and E280G, which could support the importance of the E280 residue in the PS1 protein contributing to the pathogenic nature of E280K. Additional ten family members were screened for the E280K mutation, and all of them were negative. Six of them presented with a variety of neuropsychiatric symptoms, including learning disabilities, epilepsy, and schizophrenia, while four family members were asymptomatic. A novel PRNP G127S mutation was found in a step-niece of the three siblings harboring the PSEN1 E280K mutation. In silico predictions for PRNP G127S mutation suggested that this might be possibly a damaging variant. Additional studies to

  2. Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

    Directory of Open Access Journals (Sweden)

    Lee SY

    2015-08-01

    Full Text Available Soo-Yun Lee,1 Wooseong Huh,2 Jin Ah Jung,3 Hye Min Yoo,2 Jae-Wook Ko,1,2 Jung-Ryul Kim2,4 1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 2Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Seoul, 3Department of Clinical Pharmacology, Inje University, Busan Paik Hospital, Busan, 4Department of Clinical Research and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea Abstract: Valproic acid (VPA is mainly metabolized via glucuronide, which is hydrolyzed by β-glucuronidase and undergoes enterohepatic circulation. Amoxicillin/clavulanic acid (AMC administration leads to decreased levels of β-glucuronidase-producing bacteria, suggesting that these antibiotics could interrupt enterohepatic circulation and thereby alter the pharmacokinetics of VPA. This study aimed to evaluate the effects of AMC on the pharmacokinetics of VPA. This was an open-label, two-treatment, one-sequence study in 16 healthy volunteers. Two treatments were evaluated; treatment VPA, in which a single dose of VPA 500 mg was administered, and treatment AMC + VPA, in which multiple doses of AMC 500/125 mg were administered three times daily for 7 days and then a single dose of VPA was administered. Blood samples were collected up to 48 hours. Pharmacokinetic parameters were calculated using noncompartmental methods. Fifteen subjects completed the study. Systemic exposures and peak concentrations of VPA were slightly lower with treatment AMC + VPA than with treatment VPA (AUClast, 851.0 h·mg/L vs 889.6 h·mg/L; Cmax, 52.1 mg/L vs 53.0 mg/L. There were no significant between-treatment effects on pharmacokinetics (95% confidence interval [CI] of AUClast and Cmax (95.7 [85.9–106.5] and 98.3 [91.6–105.6], respectively. Multiple doses of AMC had no significant effects on the pharmacokinetics of VPA; thus, no dose adjustment is necessary. Keywords: drug–drug interaction, pharmacokinetics

  3. Dance for Adults With Fibromyalgia-What Do We Know About It? Protocol for a Scoping Review.

    Science.gov (United States)

    Bidonde, Julia; Boden, Catherine; Busch, Angela J; Goes, Suelen M; Kim, Soo; Knight, Emily

    2017-02-22

    the results, (6) consulting, and (7) disseminating the knowledge. The search, title, and abstract are now completed; full text screening was carried out and authors are awaiting interlibrary loans and translations. Data extraction will start shortly after full text 'screening' is completed. Completion is expected in Fall 2017. To our knowledge this will be the first attempt to systematically identify knowledge of dance as a potential intervention for adults with fibromyalgia. This scoping review offers a feasible means for describing the evidence specific to dance and fibromyalgia; results will provide unique insights concerning the breadth and depth of literature in the area. An analysis of this body of literature as a whole may reveal new research directions or unknown ways this intervention could strengthen current management approaches of the disease. ©Julia Bidonde, Catherine Boden, Angela J Busch, Suelen M Goes, Soo Kim, Emily Knight. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 22.02.2017.

  4. Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

    Directory of Open Access Journals (Sweden)

    Naeem M

    2015-07-01

    Full Text Available Muhammad Naeem,1 Moonjeong Choi,1 Jiafu Cao,1 Yujeong Lee,1 Muhammad Ikram,2 Sik Yoon,2 Jaewon Lee,1 Hyung Ryong Moon,1 Min-Soo Kim,1 Yunjin Jung,1 Jin-Wook Yoo11College of Pharmacy, Pusan National University, Busan, 2Pusan National University School of Medicine, Yangsan, South KoreaAbstract: Single pH-dependent drug delivery systems have been widely used for colon-targeted delivery, but their efficiency is often hampered by the variation in gut pH. To overcome the limitation of single pH-dependent delivery systems, in this study, we developed and evaluated the therapeutic potential of budesonide-loaded dual pH/time-dependent nanoparticles (NPs for the treatment of colitis. Eudragit FS30D was used as a pH-dependent polymer, and Eudragit RS100 as a time-dependent controlled release polymer. Single pH-dependent NPs (pH_NPs, single time-dependent NPs (Time_NPs, and dual pH/time-dependent NPs (pH/Time_NPs were prepared using the oil-in-water emulsion method. The physicochemical properties and drug release profiles of these NPs in gastrointestinal (GI tract conditions were investigated. The therapeutic potential and in vivo distribution of the NPs were evaluated in a dextran sulfate sodium (DSS-induced colitis mice model. The pH/Time_NPs prevented a burst drug release in acidic pH conditions and showed sustained release at a colonic pH. The in vivo distribution study in the mice GI tract demonstrated that pH/Time_NPs were more efficiently delivered to the inflamed colon than pH_NPs were. Compared to the single pH_NPs-treated group, the pH/Time_NPs-treated group showed increased body weight and colon length and markedly decreased disease activity index, colon weight/length ratios, histological damage, and inflammatory cell infiltration in colon tissue. Our results demonstrate that the dual pH/time-dependent NPs are an effective oral colon-targeted delivery system for colitis therapy.Keywords: colon-specific delivery, dual-sensitive delivery

  5. Toward Predicting Social Support Needs in Online Health Social Networks.

    Science.gov (United States)

    Choi, Min-Je; Kim, Sung-Hee; Lee, Sukwon; Kwon, Bum Chul; Yi, Ji Soo; Choo, Jaegul; Huh, Jina

    2017-08-02

    data to evaluate the feasibility of the framework. Our study contributes to providing personalized social support in OHSNs. ©Min-Je Choi, Sung-Hee Kim, Sukwon Lee, Bum Chul Kwon, Ji Soo Yi, Jaegul Choo, Jina Huh. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 02.08.2017.

  6. PEGylated apoptotic protein-loaded PLGA microspheres for cancer therapy

    Directory of Open Access Journals (Sweden)

    Byeon HJ

    2015-01-01

    Full Text Available Hyeong Jun Byeon,1 Insoo Kim,1 Ji Su Choi,1 Eun Seong Lee,2 Beom Soo Shin,3 Yu Seok Youn11Department of Pharmaceutical Sciences, School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea; 2Division of Biotechnology, The Catholic University of Korea, Bucheon-si, Republic of Korea; 3Department of Pharmacy, College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Republic of KoreaAbstract: The aim of the current study was to investigate the antitumor potential of poly(D,L-lactic-co-glycolic acid microspheres (PLGA MSs containing polyethylene glycol (PEG-conjugated (PEGylated tumor necrosis factor–related apoptosis-inducing ligand (PEG-TRAIL. PEG-TRAIL PLGA MSs were prepared by using a water-in-oil-in-water double-emulsion method, and the apoptotic activities of supernatants released from the PLGA MSs at days 1, 3, and 7 were examined. The antitumor effect caused by PEG-TRAIL PLGA MSs was evaluated in pancreatic Mia Paca-2 cell-xenografted mice. PEG-TRAIL PLGA MS was found to be spherical and 14.4±1.06 µm in size, and its encapsulation efficiency was significantly greater than that of TRAIL MS (85.7%±4.1% vs 43.3%±10.9%, respectively. The PLGA MS gradually released PEG-TRAIL for 14 days, and the released PEG-TRAIL was shown to have clear apoptotic activity in Mia Paca-2 cells, whereas TRAIL released after 1 day had a negligible activity. Finally, PEG-TRAIL PLGA MS displayed remarkably greater antitumor efficacy than blank or TRAIL PLGA MS in Mia Paca-2 cell-xenografted mice in terms of tumor volume and weight, apparently due to increased stability and well-retained apoptotic activity of PEG-TRAIL in PLGA MS. We believe that this PLGA MS system, combined with PEG-TRAIL, should be considered a promising candidate for treating pancreatic cancer.Keywords: Poly(D,L-lactic-co-glycolic acid, controlled release, PEGylation, TRAIL, pancreatic cancer

  7. Photothermal-modulated drug delivery and magnetic relaxation based on collagen/poly(γ-glutamic acid hydrogel

    Directory of Open Access Journals (Sweden)

    Cho SH

    2017-03-01

    Full Text Available Sun-Hee Cho,1,* Ahreum Kim,1,* Woojung Shin,2 Min Beom Heo,1 Hyun Jong Noh,1 Kwan Soo Hong,3,4 Jee-Hyun Cho,3,4 Yong Taik Lim1,2 1SKKU Advanced Institute of Nanotechnology (SAINT, 2School of Chemical Engineering, Sungkyunkwan University, Suwon, 3Bioimaging Research Team, Korea Basic Science Institute, Cheongju, 4Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea *These authors contributed equally to this work Abstract: Injectable and stimuli-responsive hydrogels have attracted attention in molecular imaging and drug delivery because encapsulated diagnostic or therapeutic components in the hydrogel can be used to image or change the microenvironment of the injection site by controlling various stimuli such as enzymes, temperature, pH, and photonic energy. In this study, we developed a novel injectable and photoresponsive composite hydrogel composed of anticancer drugs, imaging contrast agents, bio-derived collagen, and multifaceted anionic polypeptide, poly (γ-glutamic acid (γ-PGA. By the introduction of γ-PGA, the intrinsic temperature-dependent phase transition behavior of collagen was modified to a low viscous sol state at room temperature and nonflowing gel state around body temperature. The modified temperature-dependent phase transition behavior of collagen/γ-PGA hydrogels was also evaluated after loading of near-infrared (NIR fluorophore, indocyanine green (ICG, which could transform absorbed NIR photonic energy into thermal energy. By taking advantage of the abundant carboxylate groups in γ-PGA, cationic-charged doxorubicin (Dox and hydrophobic MnFe2O4 magnetic nanoparticles were also incorporated successfully into the collagen/γ-PGA hydrogels. By illumination of NIR light on the collagen/γ-PGA/Dox/ICG/MnFe2O4 hydrogels, the release kinetics of Dox and magnetic relaxation of MnFe2O4 nanoparticles could be modulated. The experimental results suggest that

  8. Reklamların ve Cinsiyet Kimliği Rolünün Tüketicilerin Satın Alma Davranışları Üzerindeki Etkisi = The Effect of Advertisements and Gender Identity Role on Consumer Buying Behavior

    Directory of Open Access Journals (Sweden)

    Mehmet İsmail YAĞCI

    2010-01-01

    Full Text Available Gender is a segmentation criterion which has been used for a long time especially for the analyses of consumer behavior in traditional marketing. However an obligation has aroused to digress the traditional patterns in order to understand consumer behavior in our rapidly changing world. At this point, “gender identity role” concept which is frequently encountered in the literature reminded may help researchers in understanding complex consumer buying behavior. In this study, consumer’s gender identity’s impact on their response to advertisements and whether their socio-economic status levels’ effect their gender identities or not have been analyzed and some significant relations have been found.

  9. Informatics Observed [and] Agenda: A Tool for Agenda Setting Research [and] Telos Language Partner: Multimedia Language Learning, Authoring and Customisation [and] Towards a Consumer Perspective on Information Behaviour Research [and] The Digital Library as Access Management Facilitator [and] Knowledge and Information Management (KIM'21) [and] Perspectives of ICT in Professional Development and Education.

    Science.gov (United States)

    Cawkell, Tony; Kok, Yeong Haur; Goh, Angela; Holaday, Duncan; Hoffstaedter, Petra; Kohn, Kurt; Rowley, Jennifer; van Halm, Johan; Pye, Jo

    1999-01-01

    The following collection of articles reprinted from "CD ROM and Online Review" include "a new way of learning." Discuses research and development funding in educational technology and recommends to offer vast sums to investigate the best way of teaching a particular topic, and through that to fund the use of computers as an incidental part of the…

  10. 1942-1943 Arası Dönemde Kıbrıs Türk Kimliğinin İlk Kurumsallaşma Hareketleri Early Movements of Institutionalizing the Cypriot Turkish Identity Between 1942 and 1943

    Directory of Open Access Journals (Sweden)

    Sibel AKGÜN

    2012-09-01

    Full Text Available Cyprus has been occupying the agenda of international relationssince the mid-20th Century, and it still remains among the unsolvedproblems in the world. The island has a political history that is definedby contrasting interests and political demands in the EasternMediterranean. Apart from global and local balances, the main problem in Cyprus is the idea of nationalism that emerged mostly in 1878 and has crystallized in the process of ethnic differentiation between the two major ethnic and religious communities living in the island. This idea has been consolidated by the policies pursued by the British colonial administration and by the influences of local elites; and thus two conflicting identities emerged. How these two identities, whose objectives and methods are different from one another, firstly emerged in a serious manner is of importance in political-cultural-sociocultural terms. The factors that triggered these processes and helped them get institutionalized constitute an important issue that needs to be addressed as much as their origins. It was the 1940s when those organizations firstly formed, which would serve as social carriers in the fields of media and political and professional organization. This process, which was triggered by international developments, will be addressed by examining each of the organizations such as KATAK and Halkın Sesi. While addressing this process, whose institutional foundations were Enosis, British colonial administration policies and Cypriot Turkish nationalism; the developments of the time will also be taken into consideration. The main subject of the study, on the other hand, will be the dynamics and development of these foundations in the 1940s in terms of organization for the Cypriot Turkish community. Kıbrıs, 20. yüzyılın ortasından itibaren uluslararası ilişkileringündeminde olup, günümüzün çözümlenmemiş sorunlarından biriniteşkil etmektedir. Ada, Doğu Akdeniz’de birbirine karşıt çıkarların vesiyasi isteklerin belirlediği siyasi tarihi ile hareketli bir geçmişe sahiptir.Küresel ve bölgesel dengelerin dışında, Kıbrıs’ta asıl sorun, büyükölçüde 1878 yılından başlayan ve adanın iki büyük etnik ve dinsel halkıarasında, etnik farklılaşma süreci ile belirginleşmiş olan milliyetçilikolgusudur. Bu olguya, İngiliz sömürge yönetiminin izlediği politikalar veyerel seçkin denilen aydınlar ve elitlerin etkisi de eklenince birbirinekarşıt, çatışan bir kimlik ikiliği ortaya çıkmıştır. Amaçları ve yönelimlerifarklı olan bu kimliklerin, oluşma süreci dışında politik - kültürel -sosyo ekonomik olarak ciddi anlamda ilk ortaya çıkma süreçleriönemlidir. Bu süreci tetikleyen ve kurumsallaşmasına neden olanfaktörler, ilk oluşmaya başlama dönemleri kadar önemli ve üzerindedurulması gereken bir konudur.Kıbrıs Türk halkı içinde basın yayın, siyasi ve meslekiörgütlenme alanlarında birer sosyal taşıyıcı olan yapılarınoluşturulması 1940’lı yıllara denk gelmektedir. Uluslararasıgelişmelerin etkisi ile başlayan bu süreç, tek tek KATAK, Halkın Sesigibi sosyal taşıyıcı yapıların incelenmesi ile ele alınacaktır. Kurumsaltemelinde Enosis, İngiliz sömürge yönetimi politikaları ve Kıbrıs Türkmilliyetçiliği olan bu süreç ele alınırken, dönemin gelişmeleri de gözönünde bulundurularak bir çözümleme yapılacaktır. Ayrı ayrı elealınabilecek olan bu temellerin, Kıbrıs Türk halkı için kurumsallaşmaanlamında 1940’lı yıllardaki dinamiği ve gelişimi ise çalışmanın anakonusu olacaktır.

  11. Tracking Theory Building and Use Trends in Selected LIS Journals: More Research is Needed. A review of: Kim, Sung‐Jin, and Dong Y. Jeong. “An Analysis of the Development and Use of Theory in Library and Information Science Research Articles.” Library & Information Science Research 28.4 (Sept. 2006: 548‐62.

    Directory of Open Access Journals (Sweden)

    Carol Perryman

    2007-09-01

    Full Text Available Objective ‐ The authors measure theory incidents occurring in four LIS journals between 1984‐2003 in order to examine their number and quality and to analyze them by topic. A third objective, only identified later in the text of the study, was to compare theory development and use between Korean and international journals. Research questions asked include whether LIS has its own theoretical base as a discipline, and what characteristics the theoretical framework has.Design – Bibliometric study.Setting – Journal issues selected from four LIS journals for the time span from 1984 ‐ 2003.Subjects – Two international journals, Journal of the American Society for Information Science and Technology (JASIST and Library and Information Science Research (LISR were selected based on their high ranking in the Social Sciences Citation Index (SSCI impact factors. Two Korean journals, Journal of the Korean Society for Information Management (JKSIM and Journal of the Korean Society for Library and Information Science (JKSLIS were selected.Methods ‐ After having determined a definition of theory, and identifying different levels of theory, the authors set up rules for the identification of theory incidents, which are defined as “events in which the author contributed to the development or the use of theory in his/her own paper” (550. Content analysis of 1661 research articles was performed to measure theory incidents according to working definitions. Interrater reliability was ensured by conducting independent coding for “subfield classification, identification of theory incidents, and quality measurement” (555,using a sample of 199 articles (random selection not specified, achieving 94‐97% interrater reliability. Incidents, once identified, were evaluated for quality using Dubin’s “efficiency of law” criteria, involving measures of relatedness, directionality, co‐variation, rate of change, and “profundity,” defined as the depth to which theory is incorporated into the research study.Main Results ‐ 21.79% (n=362 of the articles contained theory incidents that were analyzed and evaluated. Trend measurement indicated an overall increase, although a slight decrease was shown in the year range 1993‐2003. International journals accounted for 61.33% of theory incidents, compared to 38.67% for the Korean journals. T‐testing showed that differences in means between Korean and international journals were not statistically significant. Topical theory areas were ranked by frequency. The top five areas were shown to be nearly identical between Korean and international journals. ANOVA was performed with significant results in the difference between efficiency ratings. Conclusion – The authors find that the overall proportion of theory incidents including both theory development and use increased through the 20‐year time span examined, and that LIS has established its own theoretical framework based upon the frequency of incidents.

  12. Fall proof: improving mobility and balance Elizabeth Best-Martini Fall proof: improving mobility and balance and Kim A Botenhagen-Di Genova Human Kinetics £24.50 0 73603 687 3 0736036873 Debra Rose Human Kinetics £38 0 73604 088 9 0736040889.

    Science.gov (United States)

    2003-09-01

    A structured balance and mobility-training programme specifically designed to reduce physical frailty and the rising incidence of falls among older people. This practical manual blends theory into practical applications and covers an introduction to the body systems, balance assessments and a discussion of contemporary motor learning principles. Tel: Customer Services 0113 255 5665. Email: hk@hkeurope.com.

  13. X-ray crystal structures of the pheromone-binding domains of two quorum-hindered transcription factors, YenR of Yersinia enterocolitica and CepR2 of Burkholderia cenocepacia: KIM et al.

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Youngchang [Midwest Center for Structural Genomics, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Chhor, Gekleng [Midwest Center for Structural Genomics, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Tsai, Ching-Sung [Department of Microbiology, Cornell University, Ithaca New York 14853; Fox, Gabriel [Department of Microbiology, Cornell University, Ithaca New York 14853; Chen, Chia-Sui [Department of Microbiology, Cornell University, Ithaca New York 14853; Winans, Nathan J. [Department of Microbiology, Cornell University, Ithaca New York 14853; Jedrzejczak, Robert [Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Joachimiak, Andrzej [Midwest Center for Structural Genomics, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago Illinois 60637; Winans, Stephen C. [Department of Microbiology, Cornell University, Ithaca New York 14853

    2017-07-24

    The ability of LuxR-type proteins to regulate transcription is controlled by bacterial pheromones, N-acylhomoserine lactones (AHLs). Most LuxR-family proteins require their cognate AHLs for activity, and some of them require AHLs for folding and stability, and for protease-resistance. However, a few members of this family are able to fold, dimerize, bind DNA, and regulate transcription in the absence of AHLs; moreover, these proteins are antagonized by their cognate AHLs. One such protein is YenR of Yersinia enterocolitica, which is antagonized by N-3-oxohexanoyl-l-homoserine lactone (OHHL). This pheromone is produced by the OHHL synthase, a product of the adjacent yenI gene. Another example is CepR2 of Burkholderia cenocepacia, which is antagonized by N-octanoyl-l-homoserine lactone (OHL), whose synthesis is directed by the cepI gene of the same bacterium. Here, we describe the high-resolution crystal structures of the AHL binding domains of YenR and CepR2. YenR was crystallized in the presence and absence of OHHL. While this ligand does not cause large scale changes in the YenR structure, it does alter the orientation of several highly conserved YenR residues within and near the pheromone-binding pocket, which in turn caused a significant movement of a surface-exposed loop.

  14. Osman Turan'ın Siyasetçi Kimliği ve Yassıada'da Yargılanması (1954-1961 Political Identity Of Osman Turan And His Trial In Yassıada (1954-1961

    Directory of Open Access Journals (Sweden)

    Zehra ARSLAN

    2013-09-01

    Full Text Available Osman Turan entered politics as the parliamentarian of Trabzonfrom Democrat Party after the elections held on 2nd of May 1954. Hecontinued his service until 1960 coup d’etat. During his service, heexpressed that he did not approve some of the enforcements ofDemocrat Party, to which he was a member, such as making Kırşehir adistrict, arrangements at universities and cautions against theopposition during the speeches he gave in Grand National Assembly ofTurkey and party group. In the post-1960 coup d’etat period (27th ofMay, a Grand Jury was constituted which led the accusations madetowards DP members after the coup d’etat and some laws grantingextraordinary authorities were enacted. Osman Turan was not presentin the Assembly due to health problems which prevented him fromrating either favorably or unfavorably. His name was mentioned withthose of oppositions since he sometimes contradicted Menderes. Therewere even rumors that he would be expelled. However, Osman Turanpreferred to keep his battle within DP. He was arrested after coup d’etatand he gave his testimony on 30th of June in 1960 for the first time. Hewas put on trial within the scope of articles no. 141 and 146 fromTurkish Penal Code in the bylaw prepared by prosecution. The onlyaccusation made in the name of Osman Turan in the bylaw was theclaim that he received a certain amount of foreign currency. As a resultof evidence he provided in addition to his defense and investigation, itwas proven that the claims against him were unreal. He experiencedsome health problems during his arrest which lasted for 16.5 months.He could not attend all of the trials for he was being treated in thehospital located in garrison. Osman Turan was one of the 45 defendantswho were arrested due to violation of constitutional law on 15th ofSeptember 1961 and acquitted later on. 2 Mayıs 1954 seçimleri ile Demokrat Parti Trabzon Milletvekili olarak aktif siyasete atılan Osman Turan, 27 Mayıs 1960 Darbesi'ne kadar bu görevini sürdürmüştür. Milletvekilliği süresince mensubu bulunduğu Demokrat Partinin Kırşehir'in ilçe haline getirilmesi, üniversitelerde yapılan düzenlemeler, muhalefete karşı alınan tedbirler vb. uygulamalarını tasvip etmediğini TBMM ve parti grubunda yaptığı konuşmalarda dile getirmiştir. 27 Mayıs Darbesi sonrası DP mensuplarına yönelik suçlamaların başını çeken Tahkikat Encümeni oluşturulması ve bu encümene olağanüstü yetkiler veren kanunların çıkartılması sırasında da Osman Turan, sağlık problemleri nedeniyle mecliste bulunamamış dolayısı ile bu kanunlara lehte veya aleyhte oy vermemiştir. Menderes'le zaman zaman ters düştüğü için parti içerisinde adı, muhaliflerle birlikte anılmış hatta ihraç edileceği yönünde söylentiler ortaya atılmıştı. Fakat mücadelesini DP içerisinde sürdürme yolunu seçen Osman Turan, darbe ile birlikte tutuklanmış, ilk ifadesini de 30 Haziran 1960 tarihinde vermiştir. İddia makamı tarafından hazırlanan kararnamede, Türk Ceza Kanununun 141 ve 146ncı maddeleri kapsamında yargılanmıştır. Kararnamede Osman Turan'ın adının geçtiği tek suçlama ise bir miktar döviz aldığı iddiası olmuştur. Savunmasına ek olarak sunduğu deliller ve yapılan soruşturmalar sonucunda aleyhinde yapılan suçlamaların gerçek dışı olduğu kanıtlanmıştır. Toplam 16,5 ay tutukluluk döneminde sağlık problemleri yaşamış ve garnizondaki hastanede tedavi altına alındığı için duruşmaların tümüne iştirak edememiştir. Osman Turan, 15 Eylül 1961 tarihinde anayasayı ihlal suçundan tutuklu bulunup beraatına karar verilen 45 sanık arasında yer almıştır.

  15. Application of the Single Hardening Model in the Finite Element Program ABAQUS

    DEFF Research Database (Denmark)

    Jakobsen, Kim Parsberg

    model, developed by Lade and Kim (Kim & Lade 1988, Lade & Kim 1988a, Lade & Kim 1988b) is implemented as a user defined material module, UMAT, in the commercial finite element program, ABAQUS. The advantages of the Single Hardening Model Iie in its ability to predict elastic and plastic displacements...

  16. In situ rumen degradability characteristics of rice straw, soybean ...

    African Journals Online (AJOL)

    In situ rumen degradability characteristics of rice straw, soybean curd residue and peppermint (Mentha piperita) in Hanwoo steer (Bos Taurus coreanae). Byong Tae Jeon, KyoungHoon Kim, Sung Jin Kim, Na Yeon Kim, Jae Hyun Park, Dong Hyun Kim, Mi Rae Oh, Sang Ho Moon ...

  17. Browse Title Index

    African Journals Online (AJOL)

    Items 6201 - 6250 of 11090 ... Byong Tae Jeon, KyoungHoon Kim, Sung Jin Kim, Na Yeon Kim, Jae Hyun Park, Dong Hyun Kim, Mi Rae Oh, Sang Ho Moon. Vol 10, No 65 (2011), In vitro activity of certain antimicrobial agents in combination with Augouardia letestii hexane extracts against methicillin-resistant Staphylococcus ...

  18. EDITORIAL: Focus on Plasma Medicine

    Science.gov (United States)

    Morfill, G. E.; Kong, M. G.; Zimmermann, J. L.

    2009-11-01

    -pressure microwave plasmas in an N2 and O2 gas mixture M K Singh, A Ogino and M Nagatsu Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma H J Lee, C H Shon, Y S Kim, S Kim, G C Kim and M G Kong The acidification of lipid film surfaces by non-thermal DBD at atmospheric pressure in air A Helmke, D Hoffmeister, N Mertens, S Emmert, J Schuette and W Vioel Reduction and degradation of amyloid aggregates by a pulsed radio-frequency cold atmospheric plasma jet D L Bayliss, J L Walsh, G Shama, F Iza and M G Kong The effect of low-temperature plasma on bacteria as observed by repeated AFM imaging René Pompl, Ferdinand Jamitzky, Tetsuji Shimizu, Bernd Steffes, Wolfram Bunk, Hans-Ulrich Schmidt, Matthias Georgi, Katrin Ramrath, Wilhelm Stolz, Robert W Stark, Takuya Urayama, Shuitsu Fujii and Gregor Eugen Morfill Removal and sterilization of biofilms and planktonic bacteria by microwave-induced argon plasma at atmospheric pressure Mi Hee Lee, Bong Joo Park, Soo Chang Jin, Dohyun Kim, Inho Han, Jungsung Kim, Soon O Hyun, Kie-Hyung Chung and Jong-Chul Park Cell permeabilization using a non-thermal plasma M Leduc, D Guay, R L Leask and S Coulombe Physical and biological mechanisms of direct plasma interaction with living tissue Danil Dobrynin, Gregory Fridman, Gary Friedman and Alexander Fridman Nosocomial infections-a new approach towards preventive medicine using plasmas G E Morfill, T Shimizu, B Steffes and H-U Schmidt Generation and transport mechanisms of chemical species by a post-discharge flow for inactivation of bacteria Takehiko Sato, Shiroh Ochiai and Takuya Urayama Low pressure plasma discharges for the sterilization and decontamination of surfaces F Rossi, O Kylián, H Rauscher, M Hasiwa and D Gilliland Contribution of a portable air plasma torch to rapid blood coagulation as a method of preventing bleeding S P Kuo, O Tarasenko, J Chang, S Popovic, C Y Chen, H W Fan, A Scott, M Lahiani, P Alusta, J D Drake and M Nikolic A two

  19. Comorbidities in obstructive lung disease in Korea: data from the fourth and fifth Korean National Health and Nutrition Examination Survey

    Directory of Open Access Journals (Sweden)

    Park HJ

    2015-08-01

    Full Text Available Hee Jin Park, Ah Young Leem, Sang Hoon Lee, Ju Han Song, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Kyung Soo Chung Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute of Chest Disease, Yonsei University College of Medicine, Seoul, South Korea Background: Comorbidities can occur frequently in patients with chronic obstructive pulmonary disease (COPD and can influence mortality and morbidity independently. It is increasingly recognized that many patients with COPD have comorbidities that have a major impact on their quality of life and survival. Therefore, we investigated the prevalence of comorbidities in Korean COPD populations. Methods: We used data obtained in the 6 years of the fourth and fifth Korean National Health and Nutrition Examination Survey (KNHANES IV and V. Among 50,405 subjects, 16,151 subjects aged ≥40 years who performed spirometry adequately were included in this study. Airway obstruction was defined as forced expiratory volume in 1 second/forced vital capacity <0.7, and the Global Initiative For Chronic Obstructive Lung Disease stage was used to evaluate the severity of airway obstruction. Statistical analyses were performed using SAS 9.2. Results: Among the 16,151 subjects (43.2% male, 56.8% female; mean age: 57.1 years for men and 57.2 years for women, 13.1% had obstructive lung function; 11.3%, restrictive lung function; and 75.6%, normal lung function. Among individuals with obstructive lung function, 45.3%, 49.4%, and 5.3% had mild, moderate, and severe and very severe airflow limitation. The prevalence of hypertension, diabetes mellitus (DM, underweight, and hypertriglyceridemia was higher in the obstructive lung function group than in the normal lung function group (49.6% vs 35.2%; 16.8% vs 10.5%; 3.3% vs 1.3%; 19.7% vs 17.0%. According to the severity of airway obstruction, hypertension and underweight were more common as severity increased

  20. Cut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population

    Directory of Open Access Journals (Sweden)

    Chung KS

    2016-08-01

    Full Text Available Kyung Soo Chung,1,2 Ji Ye Jung,1,2 Moo Suk Park,1,2 Young Sam Kim,1,2 Se Kyu Kim,1,2 Joon Chang,1,2 Joo Han Song1,2 1Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Institute of Chest Disease, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Background: Forced expiratory volume in 1 second (FEV1/forced expiratory volume in 6 seconds (FEV6 has been proposed as an alternative to FEV1/forced vital capacity (FVC for detecting airway obstruction. A fixed cut-off value for FEV1/FEV6 in a Korean population is lacking. We investigated a fixed cut-off for FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction.Materials and methods: We used data obtained in the 5 years of the Fifth and Sixth Korean National Health and Nutrition Examination Survey. A total of 14,978 participants aged ≥40 years who underwent spirometry adequately were the study cohort. “Airway obstruction” was a fixed cut-off FEV1/FVC <70% according to the Global Initiative for Chronic Obstructive Lung Disease guidelines. We also used European Respiratory Society/Global Lung Initiative 2012 equations for the FEV1/FVC lower limit of normal.Results: Among the 14,978 participants (43.5% male, 56.5% female; mean age: 56.9 years for men and 57.0 years for women, 14.0% had obstructive lung function according to a fixed cut-off FEV1/FVC <70%. Optimal FEV1/FEV6 cut-off for predicting FEV1/FVC <70% was 75% using receiver operating characteristic curve analyses (area under receiver operating characteristic curve =0.989, 95% confidence interval 0.987–0.990. This fixed cut-off of FEV1/FEV6 showed 93.8% sensitivity, 94.8% specificity, 74.7% positive predictive value, 98.9% negative predictive value, and 0.8 Cohen’s kappa coefficient. When compared with FEV1/FVC < lower limit of normal, FEV1/FEV6 <75% tended to over-diagnose airflow limitation (just like a fixed cut

  1. Impact of statins on risk of new onset diabetes mellitus: a population-based cohort study using the Korean National Health Insurance claims database

    Directory of Open Access Journals (Sweden)

    Lee J

    2016-10-01

    Full Text Available Jimin Lee,1 Yoojin Noh,1 Sooyoung Shin,1 Hong-Seok Lim,2 Rae Woong Park,3 Soo Kyung Bae,4 Euichaul Oh,4 Grace Juyun Kim,5 Ju Han Kim,5 Sukhyang Lee1 1Division of Clinical Pharmacy, College of Pharmacy, Ajou University, Suwon, South Korea; 2Department of Cardiology, School of Medicine, Ajou University, Suwon, South Korea; 3Department of Biomedical Informatics, School of Medicine, Ajou University, Suwon, South Korea; 4Division of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon, South Korea; 5Division of Biomedical Informatics, College of Medicine, Seoul National University, Seoul, South Korea Abstract: Statin therapy is beneficial in reducing cardiovascular events and mortalities in patients with atherosclerotic cardiovascular diseases. Yet, there have been concerns of increased risk of diabetes with statin use. This study was aimed to evaluate the association between statins and new onset diabetes mellitus (NODM in patients with ischemic heart disease (IHD utilizing the Korean Health Insurance Review and Assessment Service claims database. Among adult patients with preexisting IHD, new statin users and matched nonstatin users were identified on a 1:1 ratio using proportionate stratified random sampling by sex and age. They were subsequently propensity score matched further with age and comorbidities to reduce the selection bias. Overall incidence rates, cumulative rates and hazard ratios (HRs between statin use and occurrence of NODM were estimated. The subgroup analyses were performed according to sex, age groups, and the individual agents and intensities of statins. A total of 156,360 patients (94,370 in the statin users and 61,990 in the nonstatin users were included in the analysis. The incidence rates of NODM were 7.8% and 4.8% in the statin users and nonstatin users, respectively. The risk of NODM was higher among statin users (crude HR 2.01, 95% confidence interval [CI] 1.93–2.10; adjusted HR 1

  2. Interplay of agency and ownership: the intentional binding and rubber hand illusion paradigm combined.

    Directory of Open Access Journals (Sweden)

    Niclas Braun

    Full Text Available The sense of agency (SoA refers to the phenomenal experience of initiating and controlling an action, whereas the sense of ownership (SoO describes the feeling of myness an agent experiences towards his or her own body parts. SoA has been investigated with intentional binding paradigms, and the sense of ownership (SoO with the rubber-hand illusion (RHI. We investigated the relationship between SoA and SoO by incorporating intentional binding into the RHI. Explicit and implicit measures of agency (SoA-questionnaire, intentional binding and ownership (SoO-questionnaire, proprioceptive drift were used. Artificial hand position (congruent/incongruent and mode of agent (self-agent/other-agent were systematically varied. Reported SoO varied mainly with position (higher in congruent conditions, but also with agent (higher in self-agent conditions. Reported SoA was modulated by agent (higher in self-agent conditions, and moderately by position (higher in congruent conditions. Implicit and explicit agency measures were not significantly correlated. Finally, intentional binding tended to be stronger in self-generated than observed voluntary actions. Results provide further evidence for a partial double dissociation between SoA and SoO, empirically distinct agency levels, and moderate intentional binding differences between self-generated and observed voluntary actions.

  3. Interplay of agency and ownership: the intentional binding and rubber hand illusion paradigm combined.

    Science.gov (United States)

    Braun, Niclas; Thorne, Jeremy D; Hildebrandt, Helmut; Debener, Stefan

    2014-01-01

    The sense of agency (SoA) refers to the phenomenal experience of initiating and controlling an action, whereas the sense of ownership (SoO) describes the feeling of myness an agent experiences towards his or her own body parts. SoA has been investigated with intentional binding paradigms, and the sense of ownership (SoO) with the rubber-hand illusion (RHI). We investigated the relationship between SoA and SoO by incorporating intentional binding into the RHI. Explicit and implicit measures of agency (SoA-questionnaire, intentional binding) and ownership (SoO-questionnaire, proprioceptive drift) were used. Artificial hand position (congruent/incongruent) and mode of agent (self-agent/other-agent) were systematically varied. Reported SoO varied mainly with position (higher in congruent conditions), but also with agent (higher in self-agent conditions). Reported SoA was modulated by agent (higher in self-agent conditions), and moderately by position (higher in congruent conditions). Implicit and explicit agency measures were not significantly correlated. Finally, intentional binding tended to be stronger in self-generated than observed voluntary actions. Results provide further evidence for a partial double dissociation between SoA and SoO, empirically distinct agency levels, and moderate intentional binding differences between self-generated and observed voluntary actions.

  4. Pyongyangi leedi Macbeth tõmbab niite Põhja-Koreas / Yuriko Koike

    Index Scriptorium Estoniae

    Koike, Yuriko

    2010-01-01

    Põhja-Korea liidri Kim Jong-il'i õest Kim Kyong-hui'st. Autori, Jaapani endise kaitseministri väitel on hakatud uskuma, et Kim Jong-il võib igal hetkel määrata just Kim Kyong-hui üleminekuaja valitsejaks, kes peab korraldama tema surma järel kolmanda põlvkonna Kimi võimuletuleku, kuid Kim Kyong-hui võib ise ihata saada Kim Jong-ili mantlipärijaks

  5. Produktiwiteit en verantwoordelikheid, enkele sielkundige aspekte

    Directory of Open Access Journals (Sweden)

    A. P. Venter

    1978-11-01

    Maslow se motiveringsteorie wat uit die kliniese sielkunde ontspruit het, is ook deur bedryfsielkundiges van nader beskou, veral in hoe verre dit met produktiwiteit verband het. Enkele sielkundige aspekte word bespreek ten einde op die nut van hierdie teorie in die bedryfsituasie te wys. Die vermoede bestaan dat die teorie deur bedryfsielkundiges nie altyd korrek vertolk word soos Maslow dit self uiteensit nie; veral word die verantwoordelikheidsaspek in die selfuitlewingsbehoeftes misken en nie verreken nie; 'n Logiese konklusie is dat selfuitlewing, soos deur Maslow beskryf, wel verband met produktiwiteit het.

  6. Passacaglia van J.S. Bach en Das Passagen-Werk van Walter Benjamin - literêre montage as mosaïekwerk in Memorandum. 'n Verhaal met skilderye (2006)

    OpenAIRE

    van Vuuren, Helize

    2014-01-01

    Van Niekerk se Memorandum-narratief is 'n gedenkskrif vir die elegies-realistiese skilder, Adriaan van Zyl, wat in September 2006 sterf - soos Walter Benjamin in sy laat veertigs en insgelyks met sy kunstenaarsloopbaan onderbreek. Van Niekerk stel in Memorandum vir haarself 'n uitdagende taak (soos Wiid dit formuleer aan die begin van "Memorandum 3"): om Bach se Passacaglia en fuga in C Mineur (BWV 582) (± 1715) te "vertaal" in prosa en om 'n kleiner, Afrikaanse weergawe van Benjamin se Das P...

  7. Revealing Interactions between Human Resources, Quality of Life and Environmental Changes within Socially-oriented Observations : Results from the IPY PPS Arctic Project in the Russian North

    Science.gov (United States)

    Vlasova, Tatiana

    2010-05-01

    Socially-oriented Observations (SOO) in the Russian North have been carried out within multidisciplinary IPY PPS Arctic project under the leadership of Norway and supported by the Research Council of Norway as well as Russian Academy of Sciences. The main objective of SOO is to increase knowledge and observation of changes in quality of life conditions (state of natural environment including climate and biota, safe drinking water and foods, well-being, employment, social relations, access to health care and high quality education, etc.) and - to reveal trends in human capital and capacities (health, demography, education, creativity, spiritual-cultural characteristics and diversity, participation in decision making, etc.). SOO have been carried out in industrial cities as well as sparsely populated rural and nature protection areas in observation sites situated in different bioms (from coastal tundra to southern taiga zone) of Murmansk, Arkhangelsk Oblast and Republic of Komi. SOO were conducted according to the international protocol included in PPS Arctic Manual. SOO approaches based both on local people's perceptions and statistics help to identify main issues and targets for life quality, human capital and environment improvement and thus to distinguish leading SOO indicators for further monitoring. SOO have revealed close interaction between human resources, quality of life and environmental changes. Negative changes in human capital (depopulation, increasing unemployment, aging, declining physical and mental health, quality of education, loss of traditional knowledge, marginalization etc.), despite peoples' high creativity and optimism are becoming the major driving force effecting both the quality of life and the state of environment and overall sustainability. Human induced disturbances such as uncontrolled forests cuttings and poaching are increasing. Observed rapid changes in climate and biota (ice and permafrost melting, tundra shrubs getting taller and

  8. Teratogenicity and brain aromatase-induction of monosodium ...

    African Journals Online (AJOL)

    Teratogenicity and brain aromatase-induction of monosodium glutamate in estrogen-responsive mosaic transgenic zebra fish Danio rerio. Tamer Said Abdelkader, Chang Seo-Na, Kim Tae-Hyun, Song Juha, Kim Dongso, Jae-Hak Park ...

  9. American Vitiligo Research Foundation

    Science.gov (United States)

    ... Place Vitiligo Voices Contact Welcome to The American Vitiligo Foundation Home Page Top Isabella T., California An ... 20.00 USD 20 for - 35.00 USD Vitiligo Doesn't Scare Me by Kim Kirkland Kim ...

  10. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... J Jia B M Johnson S C Johnson K S Joo S Kametani J H Kang M Kann S S Kapoor S Kelly B Khachaturov A Khanzadeev J Kikuchi D J Kim H J Kim S Y Kim Y G Kim W W Kinnison E Kistenev A Kiyomichi C Klein-Boesing S Klinksiek L Kochenda V Kochetkov D Koehler T Kohama D Kotchetkov A Kozlov P J Kroon K Kurita ...

  11. Root and critical point behaviors of certain sums of polynomials

    Indian Academy of Sciences (India)

    Seon-Hong Kim

    2018-04-24

    Apr 24, 2018 ... Root and critical point behaviors of certain sums of polynomials. SEON-HONG KIM1,∗. , SUNG YOON KIM2, TAE HYUNG KIM2 and SANGHEON LEE2. 1Department of Mathematics, Sookmyung Women's University, Seoul 140-742, Korea. 2Gyeonggi Science High School, Suwon 440-800, Korea.

  12. Tubular kidney injury molecule-1 in protein-overload nephropathy

    NARCIS (Netherlands)

    van Timmeren, Mirjan M.; Bakker, Stephan J. L.; Vaidya, Vishal S.; Bailly, Veronique; Schuurs, Theo A.; Damman, Jeffrey; Stegeman, Coen A.; Bonventre, Joseph V.; van Goor, Harry

    Kim-1, a recently discovered membrane protein, is undetectable in normal kidneys but markedly induced in proximal tubules after ischemic and toxic injury. The function of Kim-1 is unclear, but it is implicated in damage/repair processes. The Kim-1 ectodomain is cleaved by metalloproteinases and

  13. 75 FR 69160 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2010-11-10

    ... Kendall Teresa Kennedy Christin Susan Kim Chung H. Kim Hannah Boyoung Kim Johnny Han Kin Tse Wing Kiresepi... Ronald Lao Man Bee Lao Ruperto C. Laty Fabrice S. Lau Kwok Chu Lau Lawrence Juen-Yee Lau Megan Shirley... Po Polly Tsangrides Philippos Alexandros Tse Anthony Wai Chung Tse Christopher Tung Alan Leih-Sing...

  14. Working Programme 2010. Knowledge Institute for Mobility Policy

    International Nuclear Information System (INIS)

    Jorritsma, P.; Derriks, H.; Francke, J.; Gordijn, H.; Groot, W.; Harms, L.; Van der Loop, H.; Peer, S.; Savelberg, F.; Wouters, P.

    2009-12-01

    The Dutch Knowledge Institute for Mobility Policy (KiM) provides analyses of mobility that influence the policy. As a separate institute within the Ministry of Transport, Public Works and Water management, the KiM conducts strategic outlooks and policy analyses. KiM establishes working programs annually. [nl

  15. Influence of hydrogen on chemical vapour synthesis of different ...

    Indian Academy of Sciences (India)

    Administrator

    The role of hydrogen on the surface passivation behaviour of the Ni catalyst and its ..... Chae S J, Güneş F, Kim K K, Kim E S, Han G H, Kim S M,. Shin H-J, Yoon ... Xiong Y G, Suda Y, Wang D Z, Huang Y J and Ren Z F 2005. Nanotechnology ...

  16. Kimi mantlipärija sai mõjukatele ametipostidele / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2010-01-01

    Põhja-Korea pealinnas toimunud Tööliste Partei kongressil määrati riigi liidri Kim Jong-ili noorim poeg Kim Jong-un kesksõjakomisjoni aseesimeheks ja keskkomitee liikmeks. Poliitbüroosse määrati alternatiivliikmena Kim Jong-ili õe abikaasa Chang Song-taek

  17. The impact of sugar and fatty acid on the bioactivity of N-fatty acyl-L ...

    Indian Academy of Sciences (India)

    SRIKANTH VUDHGIRI

    complex on colon cancer cells J. Food Biochem. 39. 238. 36. Kim D H, Jung E A, Sohng I S, Han J A, Kim T H and Han M J 1998 Intestinal bacterial metabolism of flavonoids and its relation to some biological activities. Arch. Pharm. Res. 21 17. 37. Kim D H 2002 Herbal medicines are activated by intesti- nal microflora Nat.

  18. Brassia campestris L. ssp. chinensis L.var. utilis Tsen et Lee

    African Journals Online (AJOL)

    omodibo

    2012-12-31

    Dec 31, 2012 ... On the basis of morphological and cultural features, the pathogen ... Alternaria isolate from Purple-Caitai showed 99% identity with other ITS sequences of .... Cho KH, Park SH, Kim KT, Kim S, Kim JS, Park BS, Woo JG, Lee HJ.

  19. Graphene Synthesis and Characterization

    Science.gov (United States)

    2015-04-08

    aplications in devices, because can be properly scaled to industrial level. It was studied the experimental parameters involved in the growth of graphene...Balakrishnan, T. Lei, H. R. Kim, Y. I. Song, Y.-J. Kim, K. S. Kim, B. Özyilmaz, J:-H Ahn, B. H. Hong and S. Iijima, Nature Nanotechnology , 5, 574, 2010. Roll

  20. Urine Kidney Injury Molecule-1: A Potential Non-invasive Biomarker for Patients with Renal Cell Carcinoma

    Science.gov (United States)

    Zhang, Ping L.; Mashni, Joseph W.; Sabbisetti, Venkata S.; Schworer, Charles M.; Wilson, George D.; Wolforth, Stacy C.; Kernen, Kenneth M.; Seifman, Brian D.; Amin, Mitual B.; Geddes, Timothy J.; Lin, Fan; Bonventre, Joseph V.; Hafron, Jason M.

    2014-01-01

    Objective To evaluate the use of urine KIM-1 as a biomarker for supporting a diagnosis of kidney cancers before operation. Methods A total of 19 patients were enrolled in the study based on preoperative imaging studies. Pre-operative and follow-up (1 month) uKIM-1 levels were measured and normalized with uCr levels and renal tumors were stained for KIM-1 using immunohistochemical techniques. Results The percentage of KIM-1 positive staining RCC cells ranged from 10 to 100% and the staining intensity ranged from 1+ to 3+. Based on the KIM-1 staining, 19 cases were divided into the KIM-1-negative staining group (n =7) and the KIM-1-positive group (n = 12). Serum creatinine (sCR) levels were significantly elevated after nephrectomy in both groups. In the KIM-1 negative group, uKIM-1/uCr remained at a similar level before (0.37 ± 0.1 ng/mg Cr) and after nephrectomy (0.32 ± 0.01 ng/mg Cr). However, in the KIM-1 positive group, elevated uKIM-1/uCr at 1.20 ± 0.31 ng/mg Cr was significantly reduced to 0.36± 0.1 ng/mg Cr, which was similar to the pre-operative uKIM-1/uCr (0.37 ± 0.1 ng/mg Cr) in the KIM-1 negative group. Conclusion Our study showed significant reduction in uKIM-1/uCr after nephrectomy, suggesting that urine KIM-1 may serve as a surrogate biomarker for kidney cancer and a non-invasive pre-operative measure to evaluate the malignant potential of renal masses. PMID:23979814

  1. 29 Resensie Botha WEB 03.pmd

    African Journals Online (AJOL)

    Owner

    Willem Anker is sedert 2004 bekend as dra- maturg wat met innoverende teaterstukke soos Slaghuis, Skrapnel en Samsa-masjien die grense van teater uitdaag. In 2007 verskyn sy bekroonde debuutroman, Siegfried, waarmee beide die bildungsroman en die sogenaamde heldereis as subgenres uitgedaag word. In.

  2. DIE MlllTERE BOUKUNS IN DIE NEDER. (1500-1800)~

    African Journals Online (AJOL)

    aatkundige verhoudings van die Middcleeue en faktore soos navwer tus3cn verskillende stcd'C, wrywings -met landshere c.d.m. in aanmerking gc~eem word, dan kan hieruit afgelei word dat stedelike militere aangeleenthede. 'n belang- rikc plek ...

  3. Elustiil = Lifestyle / Urve Kask

    Index Scriptorium Estoniae

    Kask, Urve

    2006-01-01

    Töö- ja pereaastatel on leibkonna jaoks oluline eelarve, mis annab ette kulutuste mahu. Naiste ja meeste leibkondade sissetuleku tase on erinev ja toob esile sugudevahelise tarbimisstruktuuri erinevuse. Leibkonnaliikmete tarbimisstruktuur leibkonnapea soo järgi. Lastega ja lasteta leibkondade tarbimisstruktuur. Diagrammid

  4. biologie -onderwys vir die mens en sy omgewing?: 'n kritiese ...

    African Journals Online (AJOL)

    stimulus to learn more of nature has become a dreary drudge, a mountain of indigestible facts, however vaLid. (Milstein 1984) . . • Biology teachers are becoming dinosaurs in a changing environment. (Frazier 1984). Uitsprake soos die enkele voorbeelde wat hier aan- gehaal is~ verskyn in toenemende mate in meer res-.

  5. Browse Title Index

    African Journals Online (AJOL)

    Items 401 - 450 of 473 ... Vol 6, No 1 (2003), The Effect of Animal and Plant Protein-Based Diets on the Crude Protein Requirement of Cockerel Starters, Abstract. RI Salami, SOO Oyewole, AA Odunsi, IO Ogunlade. Vol 4, No 2 (2001), The effect of calcium and phosphorus supplementation on the composition of milk and blood ...

  6. Tammsaare ja piltlugu

    Index Scriptorium Estoniae

    2006-01-01

    Anton Hansen Tammsaare muuseumi korraldatud koomiksivõistlusest "Teistmoodi Tammsaare", žürii koosseis. Esimese koha pälvis Joonas Sildre koomiks "Kuningal on külm", teise koha Elina Sildre töö "Koolis", kolmanda koha soomlase Jyrki Heikkineni töö "Soo peal". Kommenteerivad Tõnu Kaalep, Maarja Lõhmus, Ivar Laus, Meelik Mallene, Mari Laaniste

  7. Active aging through employment: a critical feminist perspective on Polish policy / Ania Zbyszewska

    Index Scriptorium Estoniae

    Zbyszewska, Ania

    2016-01-01

    Aktiivsest vananemisest, vanemaealiste tööhõivest. Üle 50-aastaste töötajate positsioonist tööjõuturul, soo ja teiste sotsiaalsete faktorite mõjust sellele. Poola aktiivse vananemise poliitikatest viimase 20 aasta jooksul

  8. n narratiewe benadering tot die pastoraat: kritiese opmerkings na ...

    African Journals Online (AJOL)

    deur Carl Rogers bekend gemaak is en wat verder in die pastoraat ontgin is deur pastorale teoloë soos Wayne Oates, Paul Johnson en Carrol Wise. (De Jongh van Arkel 1988:2). Hierdie assimilering het egter beteken dat die aanspraak van die Woord nou ondergeskik aan die behoeftes van die persoon in beraad geword ...

  9. Die terapeutiese imperatief, stories en letterkunde: 'n Repliek aan ...

    African Journals Online (AJOL)

    27 Jan 2006 ... mense soos Abraham Maslow en Carl Rogers wat “self-verwerkliking” tot doelwit verhef het. Die soort individu wat sentraal staan in die ego-sielkunde verskil hemelsbreed van die individu kenmerkend van die Freudiaanse en Lacaniaanse psigoanalise. Die individu wat in hul benadering verskyn, is altyd ...

  10. Twee aardbewings of een? Die assosiasie van literêre motiewe in ...

    African Journals Online (AJOL)

    Net soos in die Matteus-evangeiie self, is hier geen duidelike aanduiding van 'n on- derlinge verband tussen die aardbewing en die ander verskynsels wat vermeld word nie. Sintaktiese merkers ontbreek, want die passasie bevat bloot vier frases wat asindeties op mekaar volg, plus een frase wat met 'n neweskikkende Kai ...

  11. AMMONIUM TOXICITY AND NITRATE RESPONSE OF AXENICALLY GROWN DACTYLORHIZA-INCARNATA SEEDLINGS

    NARCIS (Netherlands)

    DIJK, E; ECK, N

    1995-01-01

    The response to ammonium- and nitrate-nitrogen of seedlings of the calcicole orchid species Dactylorhiza incarnata (L.) Soo was tested in axenic in vitro culture of c. 3-month-old protocorms. A pronounced toxicity of ammonium ions was observed. Seedlings raised from plants of a coastal population

  12. The Napoleon Graves / Michael Tarm

    Index Scriptorium Estoniae

    Tarm, Michael

    2002-01-01

    Vilniuse lähedal leiti 1812. a. Isamaasõjas hukkunud prantsuse sõdurite matmispaik. Säilmete antropoloogilised uuringud võimaldavad kindlaks määrata hukkunute vanuse, soo ja tõenäolise surma põhjuse

  13. Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth

    Science.gov (United States)

    2016-08-16

    Pennsylvania, Pennsylvania State University, University Park, 16802- 4400, USA. 2Department of Biochemistry and Molecular Biology, Pennsylvania State...of Toxin- Antitoxin Activity. Cell 154, 1140–1150 (2013). 26. Osbourne, D. O., Soo, V. W. C., Konieczny, I. & Wood, T. K. Polyphosphate, cyclic AMP

  14. Health benefits of soy beans and soy products: a review | Venter ...

    African Journals Online (AJOL)

    Heel sojabone bevat 40% proteïene, terwyl sojameel, sojaproteïenkonsentraat en geïsoleerde sojaproteïen respektiewelik 50%, 70% en 90% proteïen bevat. Verskeie nie-nutriëntbestanddele soos isoflavone, protease-inhibeerders, fitiensuur, saponiene en fitosterole kom in sojabone voor en is moontlik vir sekere van die ...

  15. Plaadiesitlus

    Index Scriptorium Estoniae

    2005-01-01

    Heliplaatidest: Erdman/Sooäär" Peer Gynt & Other Stories" (esitlus 29. apr. Sakala keskuses), "Mi tango en Buenos Aires" (esitlus 24. apr. Sakala keskuses), Hinkus ja Maarja "Look Around" (esitlus 28. Rock Cafés grupiga Reel People)

  16. ,t'.: O.)IISPIIONG EN ONTWIKKELIN •• VAN ItIE ONDERRI ••F'LM

    African Journals Online (AJOL)

    4. Die onderrigfilms wat vir skole bestaan het, het aspekte soos verhale, tegniese vakke, geografie, geskiedenis, taal en higiene gedek. Bogenoemde films was egter baie beperk in terme van opvoedkundige waarde aangesien dit bestaan het uit materiaal wat vanaf kommersiele films afkomstig was en later aangepas is Die.

  17. P. J. N. Smal, Die Universalisme in die Psalms. Academisch ...

    African Journals Online (AJOL)

    Test

    dat die historiese element in Israel se Godsopenbaring en daarmee die insig in sy betekenis te kort gedoen word. Die betekenis van die studie vir die historia revelationis is daardeur gering; as duidelike „tydlose” sistematisering van Outestamentiese gegewens oor die betrokke onder- werpe, soos die laaste hoofstuk, bl.

  18. Siektes van peroksisome - 'n oorsig

    African Journals Online (AJOL)

    (x 14 SOO). Peroksisoomsiektes2. ,3,5.6. Ongeveer 12 genetiese siektes wat as gevolg van foute in die ontwikkeling of in die samestelling van peroksisome antstaan, is reeds beskryf. Volgens die omvang van die biogenetiese fout en die graad van verlies aan peroksisoomfunksies word hierdie sindrome in 3 groepe.

  19. 26 Resensie Barendse WEB 02.pmd

    African Journals Online (AJOL)

    Owner

    roman/memoir/ bundel/tesis/geskrif”. Soos die titel beloof, is die boek chaoties. Ek gee daarom 'n kort op- somming van die verhaal in 'n poging om orde te skep binne die chaos: Die boek begin met die verteller wat vanuit 'n sielkundige.

  20. Sad naslazhdeni / Galina Balashova

    Index Scriptorium Estoniae

    Balashova, Galina

    2003-01-01

    Eesti Metallikunstnike Liidu korraldatud ehtekunsti näitusest "Palve. Puudutus. Patt" Tallinna Kunstihoone galeriis. Taimi Soo kujundusest. Jaanika Pajuste, Julia Pihlaku, Urve Küttneri, Andrei Balashovi, Jaan Pärna, Lilian Linnaksi, Kärt Summataveti, Rein Metsa ja Harvi Varkki töödest näitusel

  1. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer. Soo Kyung ... DNA methylation is an epigenetic event that occurs frequently in colorectal cancer (CRC). ... The expression of PPP1R3C was inversely related to methylation status.

  2. Ontstaan, rol en betekenis van die Afrikaanse koerante

    Directory of Open Access Journals (Sweden)

    G. P. Pienaar

    1975-05-01

    Full Text Available Die koerant soos ons dit vandag ken, het pas 2 000 jaar oud geword, nou wel nie altyd gedruk en met kleurfoto’s versier nie, maar nietemin herkenbaar nuusblad. Ons dank vandag die Romein Cicero vir ons kennis van die heel oudste koerante.

  3. DIE SUID-AFRIKAANSE JEUG IN VOORTREKKERTYDPERK

    African Journals Online (AJOL)

    dien. Die planke en velie moes keer dat die assegaaie die mense tref. Voor die geveg het die vrouens en groter dogters koeels gegiet. Tydens die geveg het die seuns gehelp skiet terwyl die vrouens en dogters die gewere vir die mans gelaai het. Van die dogters soos Nellie. Botha (11 jaar oud) en haar sussie Fya (15 jaar.

  4. Press Liaison Committees

    African Journals Online (AJOL)

    19 Jun 1971 ... Soos duidelik blyk uit advertensies vir ambulansposte is dit beslis nie op die oomblik die geval nie. Een munisipaliteit verlang 'n standerd 7-sertifikaat en bied dan slegs. R1 860 aan as aanvangsalaris indien die kandidaat tussen 20 en 24 jaar oud is. Daar sal seker diegene wees wat aansoek doen en wat ...

  5. Kenmerkend van hierdie afdeling is die tema van ouderdom wat in ...

    African Journals Online (AJOL)

    8 Apr 2016 ... Kenmerkend van hierdie afdeling is die tema van ouderdom wat in menige van die stories voorkom. Hier is dit die onvermydelike aftakelingsproses van die liggaam (en verstand) wat 'n beduidende invloed op die skrywer het. In verhale soos “Wat 'n lieflike geraas”, “Die ou met die overall”, “Lofredes en ...

  6. Land van skedels. Nicola Hanekom. Pretoria: Protea Boekhuis ...

    African Journals Online (AJOL)

    tema is, soos te verwagte in 'n stuk wat werk met historiese materiaal, die tema van onthou. Reeds in die “skrywersnota” stel Nicola Hanekom dat “[o]ns moet altyd onthou om te onthou. Ons vergeet dit soms. Ons moet die dier binne ons in toom hou en probeer luister na die engele in die chaos”. Die gevaar van vergeet is.

  7. The psychological experience of women who survived HELLP ...

    African Journals Online (AJOL)

    Die tema van nie weet en beswyming en/of surrealistiese ervaring ondersteun die kognitiewe aspekte van die HELLP sindroom. Temas wat gevoelens van geen beheer, warrelwind en/of vinnige tempo en ondersteuning uitgesprek het, het saam opgetree om die ervaring te bind. Ten slotte,emosies soos woede, ...

  8. Muusikalised jutustused

    Index Scriptorium Estoniae

    2008-01-01

    Üritustest kontsertsarja Soul Spectrum raames Kumus: 14. märstsil Ursula Rucker (soojendusesinejad Riho Sibul, Jaak Sooäär ja Raul Saaremets), 15. märtsil folk-jazzlaulja Terry Callier (soojendusesinejad Tõnis Mägi ja Chalice)

  9. "Siin me oleme" staarid paljastasid Muhumaal saladusi / Katrin Pauts

    Index Scriptorium Estoniae

    Pauts, Katrin, 1977-

    2002-01-01

    Sulev Nõmmiku populaarse komöödiafilmi "Siin me oleme" (Eesti Telefilm 1978) osatäitjad Lia Laats, Kadri Jäätma, Väino Puura ja Imre Sooäär meenutasid Pädaste mõisas kokku tulles filmimise rõõme ja muresid

  10. Muusikast, muinsuskaitsest, keraamilistest lauanõudest ... : TPÜ kultuuriteaduskonna magistrantide ja doktorantide teaduskonverents 23. aprillil / Risto Paju

    Index Scriptorium Estoniae

    Paju, Risto

    2001-01-01

    Teaduskonverentsi juhatasid sisse K. Kirme, R. Pullat, H. Uibu. Ettekannetega esinesid T. Parktal, L. Suurmaa, M. Raabe, M. Loit, T. Soosõrv, M. Aarma, T. Tohver, R. Paju, O. Kozlova, A. Lõugas, M. Talvik, S. Sultson, P. Kängsep, A. Hrenova, J. Raihhelgauz

  11. Effects of calcium impurity on phase relationship, ionic conductivity ...

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 39; Issue 3. Effects of calcium impurity on phase relationship, ionic conductivity and microstructure of Na + - β / b e t a " -alumina solid electrolyte. SUNG-TAE LEE DAE-HAN LEE SANG-MIN LEE SANG-SOO HAN SANG-HYUNG LEE SUNG-KI LIM. Volume 39 Issue 3 ...

  12. Eesti sigaretiturg 2005. aastal / E Ahermaa

    Index Scriptorium Estoniae

    Ahermaa, E

    2006-01-01

    Ülevaade Eesti sigaretiturul 2005. aastal aset leidnud muutustest. Tabelid: Suitsetajate osakaal soo järgi (% vastanutest); Sigarettide illegaalse kaubanduse maht ja arvestuslik maksutulukaotus. Diagrammid: Legaalsete ja illegaalsete sigarettide vahel valiku tegemine; Sigarettide hinna ja aktsiisi võrdlus Eestis 2005. ja 2009. aastal

  13. Die verhouding tussen kerk en staat: Enkele modelle met verwysing ...

    African Journals Online (AJOL)

    ook ingaan op die vraag na die reg tot opstand teen die gesag van die staat soos dit in hierdie modelle beantwoord word. Ons wil eindig by die vraag na 'n teologiese model wat geskik is vir ons dag. 1. DIE TEOLOGIESE MODEL VAN DIE ROOMS-KATOLIEKE. KERK. Die Rooms-Katolieke Kerk se opvatting word bepaal ...

  14. Tallinna kultuuriväärtuste ameti tunnustused

    Index Scriptorium Estoniae

    2014-01-01

    Parimatest restaureeritud mälestistest: Pagari 1, Raua 39, Õllepruuli 5, Allika 4, Kooli 9, Rahukohtu 5, Toom-Kooli 21, Toompuiestee 24. Parimatest restaureeritud majadest Tallinna miljööaladel: Köie 3, Soo 42, Vabriku 10, Kentmanni 18, Loode 14, Ristiku 4B, Sõbra 20, Valgevase 12, Wiedemanni 11

  15. die geni,rasie-ini'erva[, van dte suid-afrikaanse vleismerino 31)00

    African Journals Online (AJOL)

    met 'n afname in kuddegrootte is hierdie parameter beraam vir elke afsonderlike stratum van die teeltstruk- tuur soos diagrammaties voorgestel in Figure I en 2. Die belangrikheid hiervan is veral geled in die feit dat teeltvordering in die bedryf in 'n groot mate aangewys. f l 0. - 1 0. Int erva I. Velandering in die interval lll lare.

  16. Portrette in my gang. Dolf van Niekerk. Pretoria: Protea Boekhuis ...

    African Journals Online (AJOL)

    instink en rede kan verder afgelees word uit die metaforiese lading in 'n titel soos Nag op 'n kaal plein (wat, terloops, herinner aan die titel van Bernlef se skitterende Nederlandse vertalings van die Sweedse Nobelprysdigter Tomas. Tranströmer, Het wilde plein). Van Niekerk se belangstelling in die klassiek—in die huidige ...

  17. Die na-binne of introverte gengtheid van ^Kerk en wêreld 2000'

    African Journals Online (AJOL)

    gebeur horn aangaan. Hierdie is dan ook een van die redes waarom die NHKA daartoe oorgegaan bet om 'n werkdokument soos Kerk en wêreld 2000 daar te stel. Hy wou duidelik uitspel dat, alhoewel hy teologies dink, hy dit doen ten behoewe van die wêreld. Nadat die Kerk dit oor die verstaan van sy fondamente gesé ...

  18. Kas tüdrukud jõuavad järele? Soolise infokihistumise arengujoontest Eestis / Veronika Kalmus

    Index Scriptorium Estoniae

    Kalmus, Veronika, 1973-

    2004-01-01

    Sugudevahelistest erinevustest infotehnoloogia kasutamises ning olulise informatsiooni valdamises. 14-19-aastaste noorte seas tehtud küsitlusuuringute tulemustest. Diagrammid: Internetiühenduse olemasolu kodus (%); Interneti märkimisväärne kasutamine (%); Arvutikasutusoskuste keskmised enesehinnangud. Tabelid: Infokihistumise aspektid soo lõikes vanuserühmades 2002-03. a.; Lineaarse regressioonanalüüsi tulemused

  19. Operation and Maintenance Manual for Draw Off-Holdback (DOHB) Tension Machine

    Science.gov (United States)

    1982-12-01

    Pickling and Treatment Appendix C -Nonferrous Pipe Pickling and Treatment (copper. copper-nickel, bronze) SZf CODE IDENT NO. REV ... .. f1 .h~n A 16603...Fiand3. Fr.nC.. G&I’mory. 0,..,., Holand . India. Ilan. Italy. Jeoon Womr,c0 New4 Zedaland. Nolitril. Peu SooM Africa. Seamn. Sweal", Switzerland. Turkey

  20. 'n ope brief aan Dorian Gray en 'n peiling van die Afrikaanse ...

    African Journals Online (AJOL)

    19 Mrt. 2018 ... kritieser lesers (nie net vriende, Instagram-ondersteuners en kollegas nie) en 'n in- tensiewer ontginning van beskikbare toetsterreine. Het hy ooit gedigte voorgelê vir. NB-Uitgewers se Nuwe stemme-reeks? Sterk debutante soos Ilse van Staden, Bernard. Odendaal, Ronelda Kamfer, Loftus Marais, Hennie ...

  1. Field implementation of fiber-reinforced polymer (FRP) deck panels.

    Science.gov (United States)

    2017-06-01

    Jeffery S. Volz, S.E., P.E., Ph.D., Kamal H. Khayat, PhD, P.Eng. http://orcid.org/0000-0003-1431-0715, Soo Duck Hwang, Ph.D. http://orcid.org/0000-0003-2178-1531, Hesham Tuwair, Ph.D., Jonathan T. Drury, Amy S. Crone : Although still in their infancy...

  2. Archtecture According to Children : Tree House World / Pille Runnel

    Index Scriptorium Estoniae

    Runnel, Pille, 1974-

    2015-01-01

    Linnalaste ja -noorte teemalisest näitusest "Niisama linnas" ("Chilling Around the Town") Eesti Rahva Muuseumis 16. mai 2014-11.01 2015. Teostuse on leidnud ka onnikavandite võistlusele auto-onni idee saatnud 10-aastase poisi Artur Soo unistus - "Onn ratastel OÜ" - vanasse veoautosse ehitatud onn

  3. HIV ravi võtab peagi sadu miljoneid / Kadri Ibrus

    Index Scriptorium Estoniae

    Ibrus, Kadri

    2007-01-01

    HIV-positiivsete ravikulud on Eestis hüppeliselt kasvamas, kuna aastate eest nakatunud inimesed hakkavad nüüd vajama tõsist ravi. Lisaks diagrammid: Eestis levib HIV maailmas pea kõige kiiremini ; 2006. aastal nakatunud soo ja vanuse järgi

  4. Turism rikastab : rahvusvaheline turismikonverents

    Index Scriptorium Estoniae

    2006-01-01

    28. septembril toimus Tallinnas Rahvusraamatukogus rahvusvaheline turismikonverents"Turism rikastab". Ülevaade majandus- ja kommunikatsiooniministeeriumi majandusarengu asekantsleri Maria Värtoni, Graham Mckenzie, Linnar Viigi, Nick Skelloni, Mario Ascencao (Haagi ülikool), David Carsoni (Ulsteri ülikool), Vesa Heikkineni ja Imre Sooääre ettekannetest

  5. Kutseõppeasutuste õpetajad = Pedagogues of vocational education institutions / Tiiu-Liisa Rummo

    Index Scriptorium Estoniae

    Rummo, Tiiu-Liisa

    2007-01-01

    Eesti lähituleviku eesmärgiks on motiveerida kutsehariduse pedagooge ja spetsialiste kutseharidussüsteemis töötama. Kutseõppeasutuste pedagoogid vanuserühma, soo, ametijärgu ja haridusastme järgi. Lisatud diagramm ja tabelid

  6. Jesus Christus

    African Journals Online (AJOL)

    Test

    Hiervan is teoloë soos Karl Barth, John ..... Brunner, E., 1960, Die christliche Lehre von der Kirche, vom Glauben und von der .... Greig, P., 2007, God on mute, Survivor/Kingsway Communications, Eastbourne. Guder .... Testament in the Olivétan Bible of 1535', Koers 66(1/2) 1–22. http://dx.doi. .... Harper Collins, New York.

  7. Missionale kerkwees

    African Journals Online (AJOL)

    Test

    Paul Hooker (2008) werk die begrip soos volg uit: ...... Brunner, E., 1960, Die christliche Lehre von der Kirche, vom Glauben und von ..... P.S., 1960, Images of the church in the New Testament, Westminister John Knox, ... Testament in the Olivétan Bible of 1535', Koers 66(1/2) 1–22. http://dx.doi. .... Harper Collins, New York.

  8. Eksperiment - teeme kõige noorema Vanemuise näitleja vanaemaks

    Index Scriptorium Estoniae

    2010-01-01

    Vanemuise teatri noorim näitleja Liisa Pulk osaleb Anne-Ly Soo (grimmiala juht) ja Erle Vannuse (jumestuskunstnik) lavagrimmi eksperimendis. Artiklis teatrigrimeerija tööst lähemalt. Lisaks näitleja CV: "Liisa Pulk"

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Soo-Dong Woo1 Jae Young Choi2 Yeon Ho Je2 Byung Rae Jin3. Department of Plant Medicine, College of Agriculture, Life and Environment Sciences, Chungbuk National University, Cheongju 361-763, Korea; School of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul ...

  10. ONDERHOUD MET EDWIN ARRISON1

    African Journals Online (AJOL)

    So ons het daardie week gehad, en in daardie week het daar 'n hele klompie goed gebeur waarvan ek heeltemal onbewus was. Byvoorbeeld, ek het skielik daardie week besef iemand soos Jeremiah. Wright kom na die konferensie toe. Ek weet nie of jy vir Jeremiah Wright ken nie, maar hy was Barack Obama se pastoor ...

  11. Nooruslik kaupmeheemand kavatseb äri laiendada / Hille Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Hille, 1941-2014

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 23. märts lk. 8. Tallinnas Vana-Kalamaja tänaval paikneva Alma Äri omanik Alma Sooäär avas oma esimese poe enam kui 15 aastat tagasi Nõmmel, praegu plaanib poeomanik majapidamistarvete äri laiendamist. Kaart: Alma Äri

  12. Vrede in die boek van Esegiël

    African Journals Online (AJOL)

    14 Aug 2015 ... Die eerste en derde gedeeltes van die boek kan soos volg in verdere onderafdelings ingedeel word: • 1–24: Profesieë (van oordeel) teen Israel voor die val van Jerusalem. • 1–3: Roepingsvisioen. • 4–11: Tekens en gesigte wat oordeel oor Israel aankondig en veral teen Juda en Jerusalem gerig is.

  13. Multiobjective Optimization of Linear Cooperative Spectrum Sensing: Pareto Solutions and Refinement.

    Science.gov (United States)

    Yuan, Wei; You, Xinge; Xu, Jing; Leung, Henry; Zhang, Tianhang; Chen, Chun Lung Philip

    2016-01-01

    In linear cooperative spectrum sensing, the weights of secondary users and detection threshold should be optimally chosen to minimize missed detection probability and to maximize secondary network throughput. Since these two objectives are not completely compatible, we study this problem from the viewpoint of multiple-objective optimization. We aim to obtain a set of evenly distributed Pareto solutions. To this end, here, we introduce the normal constraint (NC) method to transform the problem into a set of single-objective optimization (SOO) problems. Each SOO problem usually results in a Pareto solution. However, NC does not provide any solution method to these SOO problems, nor any indication on the optimal number of Pareto solutions. Furthermore, NC has no preference over all Pareto solutions, while a designer may be only interested in some of them. In this paper, we employ a stochastic global optimization algorithm to solve the SOO problems, and then propose a simple method to determine the optimal number of Pareto solutions under a computational complexity constraint. In addition, we extend NC to refine the Pareto solutions and select the ones of interest. Finally, we verify the effectiveness and efficiency of the proposed methods through computer simulations.

  14. * * E rnst F uchs , Was ist Theologie1J. C. B. Mohr, Tübingen, 1953 ...

    African Journals Online (AJOL)

    Test

    waarheidgetuienis en wysbegeerte is die denkbeweging van die waarheids- soeker. Die teologie dink, terwyl dit verhelder wat dit glo; die wysbegeerte dink, terwyl dit in begrippe verhelder wat dit begryp. Die wéreld waarmee die teologie sig besighou, is die mens wat deur God opgeroep word om mens te wrees soos die ...

  15. Luuleõhtu "Sitikas suudleb kuud"

    Index Scriptorium Estoniae

    2009-01-01

    29. okt. toimub Adamson-Ericu muuseumis luuleõhtu, kus esinevad Andres Ehin luule ja häälutustega, Mart Soo kitarril ja Brian Melvin löökriistadel. Üritus toimub Kōkyō Hatanaka (sünd. 1947) näituse "Aasia minu südames. Jaapani klassikaline maal nihonga" raames

  16. 'N perd van 'n ander kleur sas somerset (1942-1986) | Wessels ...

    African Journals Online (AJOL)

    Naas die bekende vlootvaartuie soos byvoorbeeld duikbote, vliegdekskepe en missieldraende aanvalsvaartuie, is daar in die meeste vlote ter werêld ander vaartuigtipes wat soms 'n groot deel van hul leeftyd hawegebonde is, maar nogtans waardevolle diens ten behoewe van ander skepe of ter beskerming van hawens ...

  17. 'N PERD VAN 'N ANDER KLEUR SAS SOMERSET (1942-1986)

    African Journals Online (AJOL)

    Naas die bekende vlootvaartuie soos byvoorbeeld duikbote, vliegdekskepe en missieldraende aanvalsvaartuie, is daar in die meeste vlote ter wereld ander vaartuigtipes wat soms 'n groot deel van hul leeftyd hawegebonde is, maar nogtans waardevolle diens ten behoewe van ander skepe of ter beskerming van hawens ...

  18. Naised põllumajanduses = Women in agriculture / Aili Maanso

    Index Scriptorium Estoniae

    Maanso, Aili

    2006-01-01

    2005. a. struktuuriuuringu andmetel oli Eesti ligi 28 000 põllumajanduslikus majapidamises 90 850 hõivatut. Püsitööjõust (peretööjõud ja alalised töötajad) oli mehi 51,1% ja naisi 48,9%, 37% majapidamistest oli naisjuht. Majapidamiste juhid soo ja vanuse järgi. Tabelid

  19. 36 http://spilplus.journals.ac.za/

    African Journals Online (AJOL)

    behaviorisme, veral van Watson (Behaviorism, 1924) en ;.leiss (A Theoretical basis of human behaviour, 1924, hersiene uitgawe 1929). Soos bekend, is die behaviorisme die opvatting dat psigologiese verskynsels voldoende behandel en verklaar kan word deur 'n studie van die reaksies van 'n organisme op stimuli sonder ...

  20. Bleek planeet

    African Journals Online (AJOL)

    Owner

    king”) en verskynsels soos el niño word be- trek. Aardverwoesting, natuurverskynsels en die geïmpliseerde rol van die mens as (dikwels gefaalde) behoeder van die natuur word in hierdie bundel met deurdagte en suggestie- ryke taal onder woorde gebring. In Bleek planeet werk heelwat van die ge- digte intertekstueel.

  1. Jazz-muusikud tulevad kevadet tooma / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2009-01-01

    Pärnus Jazzkaare festivalil esinejatest: norra laulja Solveig Slettahjell 19. aprillil Eliisabeti kirikus, Hedvig Hanson kontserdiga "Rahvaste hällilaulud" 21. apr. Pärnu kontserdimajas, duo Jaak Sooäär - Tuule Kann 22. apr. Pärnu raekojas ja Andy Emleri trio 23. apr. Ammende villas. Jazzkaare festivali ajaloost korraldaja Anne Ermi sõnul

  2. PER 2009(4)

    African Journals Online (AJOL)

    PER Electronic Law Review - Potchefstoomse Elektroniese Regsblad

    38 In Wes-Australië is die gekodifiseerde verweer van noodweer, soos vervat in die Criminal. Code, in 2008 op grond van ... 39 In Victoria word noodweer in die algemeen deur a 9AC en 9AE Crimes Act 1958 gereël, terwyl a 9AH spesifieke ...... uitg (Printing Things Potchefstroom 2005). Roth Briefing Paper No 3/07.

  3. http://spilplus.journals.ac.za/

    African Journals Online (AJOL)

    Shakespeare (met name soos Malvolio, Benvolio), Congreve (vergelyk die volgende name, almal uit The Way of the World: Sir Willfull, Lady Wishfort, Petulant, Mirabell,. Fainall), Dickens (met sy Scrooge, Oliver Twist, Richard Swiveler), Sheridan (Lady. Sneerwell, Mrs. Candour uit The School for Scandal) en selfs Etienne ...

  4. LANGUAGE IN MILITARY SERVICE

    African Journals Online (AJOL)

    Vanaf sy stigting in 1912 tot vandag het doeltreffende taalgebruik in beide amptelike voertale 'n hoofrol gespeel en die rol is selfs verskans in die bepalings vim Artikel137 van die Verdedigingswet. 1957, soos gewysig. Hiervolgens is gelykberegtiging van die beide amptelike voertaJe die SAW se beleid. Die voertaJe in ...

  5. The Design and Development of an Intelligent Planning Aid

    Science.gov (United States)

    1986-07-01

    Corps sector, the Worthe terminal Moralrie, which uses to over SOO feet and forms a hilly spine from northwest to southeast across...European neutrals with nig- ged geography and territorial armies is the ana or hedgehog defense, which uses terrain choke points and towns which

  6. Deon Meyer

    African Journals Online (AJOL)

    Owner

    of ten minste gekontekstualiseer, word. By die gastehuis, La Petite Margaux, is daar drie lyke met drie perfekte kopskote. Twee van die oorledenes is militêre tipes, oud-SAPD- lyfwagte wat as persoonlike sekuriteitswagte vir Jeanette Louw, besturende direkteur van. Body Armour (soos in Onsigbaar en 7 dae), ge- werk het.

  7. Top 10 Estonian albums of 2004 / Igor Garshnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2004-01-01

    Heliplaatidest: Arvo Pärt "Pro et contra", Various composers "Baltic Voices 2", Raimo Kangro "Displays", Toivo Tulev "Be Lost in the Call", Indrek Vau and Mati Mikalai "Estonian Trumpet Music", Erdmann/Sooäär "Dessert Time, Peer Gynt & Other Stories", Alo Mattiisen "50 parimat laulu", Riho Sibul "Must", Rein Rannap "Tantsib klaveril", Eesti Keeled "Kella tiksumist..."

  8. Ander lewens. 'n Roman in drie dele. André P. Brink. 2007 ...

    African Journals Online (AJOL)

    Owner

    2 Jan 2009 ... de wat naas 'n werklikheid in die teks geplaas word sodat karakters kan ... wie hy nie kans gesien het om te trou nie, en. Lydia. Hy kan ... Soos die eerste ver- haal word hierdie man ook 'n vreemdeling vir homself, maar hy staan spesifiek uitgesonder as die Ander vir albei groepe in die restaurant tydens die ...

  9. Pentateugtradisies in die boek Hosea

    African Journals Online (AJOL)

    om te bepaal of die verwysing na 'n gebeure te doen het met die verre verlede of met die .... Hosea 2:1-2 JHWH se trou aan sy beloftes. ... dat huile na Egipte sal terugkeer. Die presiese bedoeiing van die woorde 'huile sal terugkeer na Egipte' is omstre- de. Kommentatore soos Rudolph meen dat dit verstaan moet word as ...

  10. uie twe

    African Journals Online (AJOL)

    dictatorships began to disturb the balance of power in Europe. tn South Africa this gave rise to a new crJsis of divided loyalties, culminating in arguments about the country's ... met leiers soos Stalin, Hitler en Mussolini het Europese ...

  11. Sirbi tegijad läbi aegade

    Index Scriptorium Estoniae

    2004-01-01

    Toimetaja asetäitjad: Katrin Kivimaa, Reet Varblane jt. Kunst, arhitektuur: Alo Hoidre, Boris Lukats, Ressi Kaera, Jaak Olep, Ike Volkov, Mirjam Peil, Tiina Käesel, Katrin Kivimaa, Vappu Vabar, Reet Varblane, Mari Laaniste. Kunstnikud (arvutikujundus): Tõnu Soo, Ann Gornischeff, Gädvi Kuklase, Piia Ruber. Fotograafid: Solomon Rosenfeldt, Endel Köster, Kalju Suur, Arno Saar, Teet Malsroos

  12. Die begrafnisdíens

    African Journals Online (AJOL)

    Num 20: 1; Jos 24: 30; Hand 5: 5 - 11). Selfs van die ... Gebruike rondom die begrafnis het van geslag tot geslag gewissel. De Vaux ... der geskied deur die hoorders 'te onderrig, te vermaan, te vertroos en te bestraf, soos dit in elke geval ..... gehandhaaf hoef te word, veral in die lig van die feit dat die predikant die kerklike.

  13. Vana mõisahoone ärkas elule / Heli Salong

    Index Scriptorium Estoniae

    Salong, Heli, 1958-

    2008-01-01

    Muhus asuva Pädaste mõisa peahoone avamist tähistati kultuuriprogrammiga. Kohal viibisid ka president Toomas Hendrik Ilves ja proua Evelin Ilves. Juuresoleval fotol Muhu kooliõpetaja Tiina Saar, mõisaomanikud Martin Breuer ja Imre Sooäär ning proua Evelin Ilves härrastemaja linti läbi lõikamas

  14. die doeltreffendheid van die afrikaanse woordelys en spelreels

    African Journals Online (AJOL)

    sluiting by die reel vir die verdubbeling van medeklinkers na 'n kort, be- klemtoonde klinker, woorde soos ballet, ballon, terras, terrein, dissipel en dissipline slegs met een konsonant na die eerste vokaal gespel moes word, omdat daardie voorafgaande vokaal onbeklemtoon is. Ook hierdie uit- sondering op die reel word ...

  15. Jazz festival offers mellow way to get into festive spirit / Aleksei Gunter

    Index Scriptorium Estoniae

    Gunter, Aleksei, 1979-

    2003-01-01

    Aafrika laulja Malia kontserdist Sakala keskuses 9. dets.; Jaak Sooääre ja taani kitarristi Pierre Dorge kontserdist Tallinna kunstihoones 4. dets.; Hedvig Hansoni ja Andre Maakeri kontserdist Niguliste kirikus 11. dets.; ameerika ansambli Gold Company Sextet kontsertidest Tallinnas 14. dets. ja Pärnus 15. dets. festivali Jõulujazz raames

  16. Eestimaa turismitöökoda MATKAMIKS 2004

    Index Scriptorium Estoniae

    2004-01-01

    Turismiseminarist "Kultuur turismis. Turism kultuuris", kus turismist ja kultuurist rääkisid Riigikogu liige Imre Sooäär, EHRL juhatuse esimees Tarmo Sumberg, ajaloolane Lauri Vahtre, lavastaja Katri Kaasik-Aaslav ning Viljandi Kultuuriakadeemia rektor Anzori Barkalaja

  17. Resource-Efficient Data-Intensive System Designs for High Performance and Capacity

    Science.gov (United States)

    2015-09-01

    76, 79, 80, and 81.] [9] Anirudh Badam, KyoungSoo Park, Vivek S. Pai, and Larry L. Peterson. HashCache: cache storage for the next billion. In Proc...Jeffrey Dean, Sanjay Ghemawat, Wilson C. Hsieh, Deborah A. Wallach, Mike Burrows , Tushar Chandra, Andrew Fikes, and Robert E. Gruber. Bigtable: A

  18. Ekwivalentverhoudings in tweetalige woordeboeke: implikasies vir ...

    African Journals Online (AJOL)

    user

    twee maal homonimies en ook twee maal polisemies is nie — dit word ook nie van die gebruiker verwag nie. Die betekeniswaardes vir "lig" word dus nie soos in algemene tweetalige woordeboeke van getalle in boskrif voorsien om homo- nieme te onderskei nie, en ook nie van Romeinse syfers om polisemiese beteke-.

  19. Die hormoonfabriek. Saskia Goldschmidt. Vertaal deur Daniel Hugo ...

    African Journals Online (AJOL)

    wat dan voortgaan met kommentaar op. “die skrywer” se boek. Die onderhawige teks, Die Hormoonfabriek, is Daniel Hugo se Afrikaanse vertaling uit Nederlands van Saskia Goldschmidt se gelyknamige debuutroman.Dit is dus, soos alle vertaalde romans, minstens twee maal geskryf: eers in Nederlands deur Goldschmidt, ...

  20. Invloed van intravaginale progestagene op estrusaktiwiteit by ...

    African Journals Online (AJOL)

    geneem: Een maal per dag vanaf 2 dae voor tot 4 dae na sponsinplasing, gevolg deur een maal per dag tot die aanvang van estrus en daarna sesuurliks tot aan die einde van die estrusperiode. Progesteroon- en LH- konsentrasie is bepaal volgens radio-immunologiese tegnieke soos onderskeidelik beskryf is deur Faure.

  1. Vlam in die sneeu. Die liefdesbriewe van André P. Brink en Ingrid ...

    African Journals Online (AJOL)

    In Vlam in die sneeu kry lesers dan vir die eerste maal indringende toegang tot. Brink en Jonker se verhouding in hulle eie woorde, vergesel van 'n aantal foto's en faksimilees van 'n paar briewe en tele- gramme. Soos Willie Burger in sy knap voorwoord tot die versameling aandui, kan hierdie stel briewe gelees word as 'n.

  2. "DE KAT"

    African Journals Online (AJOL)

    was die sivetkatte van besondere belang in ver- band met die vervaardiging van parfuum. Sivet- katte wat in gevangeskap aangehou is, kon twee maal per week van hulle reukstof ontdoen word.(14). Daar was dus, soos uit die vermelde besonder- hede duidelik blyk, geen verband tussen die eersgenoemde kat of cavalier ...

  3. PORTUGAL'S WAR IN ANGOLA 1961 - 1974

    African Journals Online (AJOL)

    Soos die skrywer self verklaor, het hierdie studie met die toekoms te make, maar door is baie oor die verlede daarin omdat enige skema of plan of oplossing vir 'n probleem min kans op sukseshet as dit die lesse van die verlede nie in aanmerking neem nie. Hy begin dus sy studie met 'n filosofiese betoog oor wat isoorlog?

  4. Die gebruik van 'n handpop as mede- terapeut en 'n vyfjarige ...

    African Journals Online (AJOL)

    p1243322

    waarmee Billy Beer werk en elemente soos humor en herhaling word gebruik om ouderdomstoepaslik teenoor haar te reageer en op so manier haar unieke. “taal” te praat. In die res van die artikel word eerstens aandag gegee aan sake van 'n metodologiese aard, insluitende die gebruik van die sentrale metafoor van 'n.

  5. CrossTalk: The Journal of Defense Software Engineering. Volume 21, Number 12

    Science.gov (United States)

    2008-12-01

    IACROs Competitive Non- Competitive BAA: Broad Agency Announcement IACRO: Inter-Agency Cost Reimbursement Order MIPR: Military Interdepartmental...IACRO: Inter-Agency Cost Reimbur ement Order MIPR: Military Interdepartmental Purchas Request PWS: Performance Work Statement SOO: Stateme t of Objectives

  6. Substitution of lucerne hay by ammoniated wheat straw in growth ...

    African Journals Online (AJOL)

    Lucerne hay (LH) was substituted by urea-ammoniated wheat straw (AWS) in four lamb-growth diets, all containing 60% roughage. ... Die ekonomiese voordeel van die verplasing van 'n hoë kwaliteit ruvoer, soos LH, met'n goedkoper bron (AKS), moet opgeweeg word teen die laer DMI en GDT, sowel as die nadelige effek ...

  7. 50 CFR 226.212 - Critical habitat for 13 Evolutionarily Significant Units (ESUs) of salmon and steelhead...

    Science.gov (United States)

    2010-10-01

    ...); Green River (47.2911, -121.9714); Jenkins Creek (47.3791, -122.0899); Little Soos Creek (47.4031, -122...) upstream to endpoint(s) in: Henry Creek (45.3328, -121.9110); Still Creek (45.2755, -121.8413); Unnamed (45...

  8. Disainiaasta / Bruno Tomberg

    Index Scriptorium Estoniae

    Tomberg, Bruno, 1925-

    2006-01-01

    Näitus "40 aastat disainiharidust Eestis" Eesti Tarbekunsti- ja Disainimuuseumis 19. VIII-17. IX ja Eesti disaini auhinna nominentide näitus Arhitektuuri- ja Disainigaleriis 18. IX-1. X. Disaini osalusest tänases tootmissüsteemis ja asendist kultuurisüsteemis. Taimi Soo1972. a. ruumiinstallatsiooni restauratsioonist

  9. Kas sugu on läbirääkimistel tähtis

    Index Scriptorium Estoniae

    2006-01-01

    Ülevaade Harvard Business Schooli uudiskirja Working Knowledge 2006. aasta veebruari numbris ilmunud Dina W. Pradel'i, Hannah Riley Bowles'i ja Kathleen L. McGinn'i artiklist inimese soo mõjust läbirääkimistele

  10. 04 John 03.pmd

    African Journals Online (AJOL)

    Owner

    29 Jul 2010 ... prys aan Melanie Grobler toegeken het vir dié bundel. Vanuit 'n juridiese perspektief lyk die heftige reaksies van literêre kritici, skrywers en uitgewers egter grootliks onnodig en oorbodig, soos duidelik blyk uit 'n onlangse regsproefskrif oor kopieregskending wat juis episodes uit die Afrikaanse letterkunde.

  11. EUNUG IN DIE ANTIEKE NABYE OOSTE

    African Journals Online (AJOL)

    rang. In Assiries beteken die woord “hoof-eunug”. Soos reeds vermeld (by 2), vorm die eunug 'n belangrike deel van die Assiriese burokrasie. Dokumente dui aan ... rang in die Babiloniese weermag, en so 'n amptenaar het saam met die rabsag ..... baie laat, in die inter-testamentêre periode, gebruik is vir 'n gekastreerde.

  12. De betekenis van Johan Buitendags stellingname in theologie der ...

    African Journals Online (AJOL)

    29 juli 2016 ... zich aan ons voordoet (Kants 'Wirklichkeit als Erscheinung'), maar over het geheel der dingen. 'soos dit kwansuis is' (Buitendag 2013:1). In Buitendags visie betekent dit dat systematische theologie probeert te begrijpen hoe de werkelijkheid in elkaar steekt wanneer wij daarmee geconfronteerd worden.

  13. A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects

    Directory of Open Access Journals (Sweden)

    Park SI

    2015-02-01

    Full Text Available Sang-In Park,1,* Howard Lee,1,2,* Jaeseong Oh,1 Kyoung Soo Lim,3 In-Jin Jang,1 Jeong-Ae Kim,4 Jong Hyuk Jung,4 Kyung-Sang Yu1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 2Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Clinical Trials Center, Seoul National University Hospital, Seoul, 3Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, 4LG Life Sciences, Ltd, Seoul, Republic of Korea *These authors contributed equally to this work Background: In type 2 diabetes mellitus, fixed-dose combination (FDC can provide the complementary benefits of correction of multiple pathophysiologic defects such as dysfunctions in glycemic or metabolic control while improving compliance compared with separate tablets taken together. The objective of the study reported here was to compare the pharmacodynamic (PD, pharmacokinetic (PK, and tolerability profiles of gemigliptin and extended-release metformin (metformin XR between FDC and separate tablets.Methods: A randomized, open-label, single-dose, two-way, two-period, crossover study was conducted in 28 healthy male volunteers. Two FDC tablets of gemigliptin/metformin 25/500 mg or separate tablets of gemigliptin (50 mg ×1 and metformin XR (500 mg ×2 were orally administered in each period. Serial blood samples were collected up to 48 hours post-dose to determine dipeptidyl peptidase 4 (DPP-4 activity using spectrophotometric assay and concentrations of gemigliptin and metformin using tandem mass spectrometry. Geometric mean ratios (GMRs of FDC to separate tablet formulations and their 90% confidence intervals (CIs were calculated to compare the PD and PK parameters between the two formulations. Tolerability was assessed throughout the study.Results: The plasma DPP-4 activity

  14. Monitoring the effects of doxorubicin on 3D-spheroid tumor cells in real-time

    Directory of Open Access Journals (Sweden)

    Baek N

    2016-11-01

    Full Text Available NamHuk Baek,1,* Ok Won Seo,1,* MinSung Kim,1 John Hulme,2 Seong Soo A An2 1Department of R & D, NanoEntek Inc., Seoul, Republic of Korea; 2Department of BioNano Technology Gachon University, Gyeonggi-do, Republic of Korea *These authors contributed equally to this work Abstract: Recently, increasing numbers of cell culture experiments with 3D spheroids presented better correlating results in vivo than traditional 2D cell culture systems. 3D spheroids could offer a simple and highly reproducible model that would exhibit many characteristics of natural tissue, such as the production of extracellular matrix. In this paper numerous cell lines were screened and selected depending on their ability to form and maintain a spherical shape. The effects of increasing concentrations of doxorubicin (DXR on the integrity and viability of the selected spheroids were then measured at regular intervals and in real-time. In total 12 cell lines, adenocarcinomic alveolar basal epithelial (A549, muscle (C2C12, prostate (DU145, testis (F9, pituitary epithelial-like (GH3, cervical cancer (HeLa, HeLa contaminant (HEp2, embryo (NIH3T3, embryo (PA317, neuroblastoma (SH-SY5Y, osteosarcoma U2OS, and embryonic kidney cells (293T, were screened. Out of the 12, 8 cell lines, NIH3T3, C2C12, 293T, SH-SY5Y, A549, HeLa, PA317, and U2OS formed regular spheroids and the effects of DXR on these structures were measured at regular intervals. Finally, 5 cell lines, A549, HeLa, SH-SY5Y, U2OS, and 293T, were selected for real-time monitoring and the effects of DXR treatment on their behavior were continuously recorded for 5 days. A potential correlation regarding the effects of DXR on spheroid viability and ATP production was measured on days 1, 3, and 5. Cytotoxicity of DXR seemed to occur after endocytosis, since the cellular activities and ATP productions were still viable after 1 day of the treatment in all spheroids, except SH-SY5Y. Both cellular activity and ATP production were

  15. Synthesis, Transfer, and Characterization of Nanoscale 2-Dimensional Materials

    Science.gov (United States)

    2015-09-01

    Shi Y, Hamsen C, Jia X, Kim KK, Reina A, Hofmann M, Kong J. Synthesis of few-layer hexagonal boron nitride thin film by chemical vapor deposition...hexagonal boron nitride layers. Nano Letters. 2010;10(8):3209–3215. 12. Kim KK, Hsu A, Jia X, Kim SM, Shi Y, Hofmann M, Kong J. Synthesis of...microscopy. Physical Review B. 2009;80(15):155425. 33. Kim KK, Hsu A, Jia X, Kim SM, Shi Y, Hofmann M, Kong J. Synthesis of monolayer hexagonal boron

  16. Electric Power Research in 1991

    International Nuclear Information System (INIS)

    1991-05-01

    This book of contents are a study of desalination by Kim, Young Bu, a study on efficiency test for nuclear power security by Jo, Sung Je; Ann, Nam Sung; Kim, Ho Gi, augmentation of EMS and RYU by Jung, Tae Hoe; Shin, Young Chuel, research on application for electric cars by Yu, Ann Gue, practical use oft robot for nuclear industry by Woo, He Gone; Shin, Hen Beom, a study on the characteristics of coolant structure in generator by Choi, Beng Hwan; Song, Young Chel; Kim, Jong Hark, and research of penetration rate of appliances by Park, Hong Ho; Kim, Beng Cheal; Kim, Dong Hwen.

  17. The relationship between fat depot-specific preadipocyte differentiation and metabolic syndrome in obese women

    Directory of Open Access Journals (Sweden)

    N V Mazurina

    2013-03-01

    Full Text Available Реферат по материалам статьи The relationship between fat depot-specific preadipocyte differentiation and metabolic syndrome in obese women. Park HТ, Lee ES, Cheon EP, Lee DR, Yang K-S, Kim YT, Hur JY, Kim SH, Lee KW, Kim T. Clinical Endocrinology 2012; 76, 59-66.

  18. Pop / Raul Saaremets

    Index Scriptorium Estoniae

    Saaremets, Raul

    2002-01-01

    Heliplaatidest Starsailor" Love is Here". Chicago Underground Quartet "Chicago Underground Quartet". Mower "Mower". Kim Wilde "The Very Best of". Mull Historical Society "Loss". Jill Scott "Experience: 826+"

  19. Assessment of the Genetic Variation in Bone Fracture Healing

    Science.gov (United States)

    2004-10-01

    9 A ppendices ............................................................................................. 10 3...injuries as well as acute trauma (Kim, 2003; Pittet et al., 2002). 6 Figure 1. Transverse (upper) and sagittal (lower) images obtained using

  20. Piezoelectric Nanogenerators for Self-Powered Nanosystems and Nanosensors

    Science.gov (United States)

    2013-05-15

    researchers 1. Sangmin Lee, Sung-Hwan Bae, Long Lin, Seunghyun Ahn, Chan Park, Seung Nam Cha, Young Jun Park, Hyuk Chang, Sang-Woo Kim and...Sohn, Seung Nam Cha, Dukhyun Choi * Zhong Lin Wang * Sang-Woo Kim * “ P-Type Polymer–Hybridized High-Performance Piezoelectric Nanogenerators”, Nano...Yoon Lee, † Sang-Woo Kim , *,$ Jae-Young Choi, *,† Jong Min Kim , † and Zhong Lin Wang *, “Flexible Hybrid Multi-Type Energy Scavenger”, Energy

  1. First results from RHIC-PHENIX£

    Indian Academy of Sciences (India)

    S C Johnson,. Ѕѕ. K S Joo, ѕї. S Kametani,. ½. J H Kang,. ¿. M Kann, їј. S S Kapoor,. ¾. S Kelly, B Khachaturov,. ¾. A Khanzadeev, їј. J Kikuchi,. ½. D J Kim,. ¿. H J Kim,. ¿. S Y Kim,. ¿. Y G Kim,. ¿. W W Kinnison,. ½. E Kistenev,. ¿. A Kiyomichi,. ¿. C Klein-Boesing, ѕѕ. S Klinksiek,. ¾. L Kochenda, їј. D Kochetkov, V Kochetkov,.

  2. Joint Services Electronics Program. Electronics Research at the University of Texas at Austin.

    Science.gov (United States)

    1986-09-30

    White, Physics Kyoung II Kim , ECE John White, Aerospace Tae Sung Kim , ECE Murray Wolinsky, Physics Taiho Koh, ECE * L.A. Wu, Physics Tom Koonce...on Acutc.SpehadSignal Processing, Vol. 1, March 1984, San Diego, California, pp. - ’ -’.,"" 27. Kyoung 11 Kim and Edward J. Powers, "Digital Estimation...Craig Farley, ECE, M.S., May 1985, "The Migration and Activation of Impurities in Ion- Implanted Semiconductors." Dae Yong Kim , ECE, M.S., May 1985

  3. Urban / Heidi Purga

    Index Scriptorium Estoniae

    Purga, Heidy, 1975-

    2005-01-01

    Uutest heliplaatidest Earth, Wind & Fire "Illumination", Kanye West "Late Registration", Stereo MC's "Paradise", Shaggy "Clothes Drop", Lil Kim "The Naked Truth", Babyface "Grown and Sexy", Sean Paul "Trinity"

  4. The Senses of Agency and Ownership: A Review.

    Science.gov (United States)

    Braun, Niclas; Debener, Stefan; Spychala, Nadine; Bongartz, Edith; Sörös, Peter; Müller, Helge H O; Philipsen, Alexandra

    2018-01-01

    Usually, we do not question that we possess a body and act upon the world. This pre-reflective awareness of being a bodily and agentive self can, however, be disrupted by different clinical conditions. Whereas sense of ownership (SoO) describes the feeling of mineness toward one's own body parts, feelings or thoughts, sense of agency (SoA) refers to the experience of initiating and controlling an action. Although SoA and SoO naturally coincide, both experiences can also be made in isolation. By using many different experimental paradigms, both experiences have been extensively studied over the last years. This review introduces both concepts, with a special focus also onto their interplay. First, current experimental paradigms, results and neurocognitive theories about both concepts will be presented and then their clinical and therapeutic relevance is discussed.

  5. Plaaslike bestuur en sy rol in fisiese beplanning

    Directory of Open Access Journals (Sweden)

    P. Z.J. van Vuuren

    1965-03-01

    Full Text Available Somaar uit die staanspoor wil ek verduidelik dat my bena- dering miskien vir sommige van u as te prakties en van te algemene aard mag voorkom en u moontlik sou verkies het dat ek meer moes uitwei oor die tegnieke en die beginsels van beplanning. Daardie aspekte laat ek egter aan die persone oor wat beter gekwalifiseer is om daaroor te praat as ek. Dit beteken egter nie dat ek, en ander soos ek, die aanvaarde en beproefde beginsels vir goeie beplanning kan ignoreer nie. Ek wil egter met hierdie inleidende woorde volstaan en dit aan u oordeel oorlaat om te besluit of u met hierdie bena- dering van my saamstem. Indien u nie met my saamstem nie, dan vertrou ek dat wat ek hier te sê het u minstens sal prikkel en u miskien sal aanspoor om die saak te stel soos u dit sien.

  6. Die wese, doel en belangrikheid van liggaamlike opvoeding in 'n moderne kulturele samelewing en die prinsipiële grondbeginsels waarop dit moet berus*

    Directory of Open Access Journals (Sweden)

    I. R. van der Merwe

    1963-03-01

    Full Text Available Om dat die begrip Liggaamlike Opvoeding in die alledaagsc taalgebruik ligtclik assosieer word o.a. m et sulke begrippe soos sport, liggaamsoefeninge, in Engels m et physical culture; in Duits m et kórpcrerziehung; in Grieks met gym nastiek en andcr moontlike m isleidende begrippe in aanverw ante tale, en om dat in die alledaagse spreek- taal daar wanopvattings ook kan bestaan i.v.m. so ’n begrip soos kultuur, wil ons dan ten einde m isverstand uit die weg te ruim , vir eers kortliks nagaan w at presies onder die begrippe K ultuur en Liggaamlike Opvoeding verstaan moet word voordat ’n poging aangewend w ord om bogenoemde onderwerp te ondersoek.

  7. Die belangrikheid van antropometrie, fisiese en motoriese vaardighede, sport spesifieke toetsing en sport visie tegnieke in die evaluering van rugbyspelers

    Directory of Open Access Journals (Sweden)

    S. Gray

    2012-03-01

    Full Text Available Sport is ‘n toenemend mededingende gebied van kundigheid, dus is dit noodsaaklik dat ‘natleet te alle tye op die hoogste moontlike vlak kan presteer. Baie afrigters en atlete is onder dievalse indruk dat prestasie uitsluitlik bepaal word deur fisiese vermoëns en as gevolg daarvanhet hulle versuim om in ag te neem faktore soos: fiksheidsvlakke, visuele vaardighede, liggaam samestelling, voedingstatus en die lewenstyl van die atlete.

  8. Kuidas EMTA osakonnad lähevad vastu kooli 100. tegevusaastale? / Ivari Ilja, Peeter Paemurru, Nadia Kurem...[jt.

    Index Scriptorium Estoniae

    2009-01-01

    Klaveriosakonna juhataja I. Ilja, keelpilliosak. juh. P. Paemurru, lauluosak. juh. N. Kurem, dirigeerimisosak. juh. T. Kapten, kammermuusikaosak. juh. H. Kapten, kompositsiooniosak. juh. T. Tulev, muusikateaduse osak. juh. U. Lippus, interpretatsioonipedagoogika instituudi juh. T. Reimann, koolimuusika inst. juh. K. Kiilu, jazzmuusika osak. juh. J. Sooäär, lavakunstikooli juh. I. Normet, kultuurikorralduse ja humanitaarainete osak. juh. G. Birnkraut, Tartu filiaali juh. K. Leivategija, pärimusmuusika eriala lektor ja koordinaator T. Bartosik oma osakondade tööst

  9. Are Shaman Paintings Material Religion or Religious Art?

    OpenAIRE

    Jong-chun Park

    2017-01-01

    Laurel Kendall, Jongsung Yang, and Yul Soo Yoon. God Pictures in Korean Contexts: The Ownership and Meaning of Shaman Paintings. Honolulu: University of Hawai'i Press, 2015. God Pictures in Korean Contexts: The Ownership and Meaning of Shaman Paintings is a pioneering work, one that explores the proverbial “road not taken” by previous research on the subject. The authors situate “the lives of Korean shaman paintings [musindo] in a complex South Korean world; in shaman shrines, private co...

  10. Array based Discovery of Aptamer Pairs (Open Access Publisher’s Version)

    Science.gov (United States)

    2014-12-11

    Array-based Discovery of Aptamer Pairs Minseon Cho,†,‡ Seung Soo Oh,‡ Jeff Nie,§ Ron Stewart,§ Monte J. Radeke,⊥ Michael Eisenstein ,†,‡ Peter J...ac504076k | Anal. Chem. 2015, 87, 821−828827 (24) Cho, M.; Oh, S. S.; Nie, J.; Stewart, R.; Eisenstein , M.; Chambers, J.; Marth, J. D.; Walker, F

  11. Need meeletud-meeletud tiirlevad plaadikettad / Immo Mihkelson

    Index Scriptorium Estoniae

    Mihkelson, Immo, 1959-

    2005-01-01

    Uutest eesti plaatidest Tafenau-Sibul-Helevä-Soo-Hasa "Siin on soe", "Vinland", Vanalinna Muusikamaja Kitarristuudio "KõlaCODA", Aimla-Arder-Agan-Mälgand "Mu süda, ärka üles", Trio Romanss & Modern Fox "Jesli ljubish, naidi...", Bonzo & Tõun "Andke tagasi maailm", Marje Sink "Jõululaulud", Jaan Tätte & MArko MAtvere "Laulude õhtu "Vana kuub"", Hannah "Live", Muschraum "Naterijeka", Smilers "Esimene Eesti tuur", Ines "uus päev"

  12. Toekomskunde as morele verantwoordelikheid

    Directory of Open Access Journals (Sweden)

    P. G. W. du Plessis

    1977-03-01

    Full Text Available Vir meeste van ons kortsigtiges het die jaar 2000 ’n veraf, ma- giese en newelagtige assosiasie. Ons praat baie makliker van ons er- varing van en herinnering aan die Smutsregering en die Tweede Wêreldoorlog wat 32 jaar gelede geëindig het. Maar ons voer vol- struispolitiek oor die jaar 2000 wat maar 23 jaar om die draai lê. Oor 23 jaar is die huidige geslag studente so oud soos baie van ons huidige personeel. *

  13. E. S. M ulder . Ds. S. H oekstra , Het Boek Leviticus. J. H . Kok, N. V. ...

    African Journals Online (AJOL)

    Test

    14:10 lees ons van een volkomen schaap van een jaar oud, Hoekstra omskryf dit as een een-jarig vrouwtjesschaap, die N.B.G. een eenjarige gave ooi. Soms kry ons minder juiste omskrywings b.v. in Lev. 26:13, waar sprake is nie van die verbreking van die juk soos die skrywer wil nie, maar van die jukskeie. Die inhoud ...

  14. Noudat slapende honde. Ronelda Kamfer. Kaapstad: Kwela Boeke ...

    African Journals Online (AJOL)

    Owner

    2 Jan 2009 ... gooidrome. Daar is 'n verlede wat jou agter- volg soos 'n skadu, 'n inslaap net om weer ontnugter wakker te word. Die gedigte weerspreek mekaar, in die gunstige sin van die woord. Daar is “'n foto van myself / op 6 jaar oud / besig in die tuin / om geheime te begrawe,” (“dood in die fam- ilie”), maar aan die ...

  15. SHIPshaping, an Interpretive Summary of a Seminar on Management of the Ship Environment to Improve Navy Effectiveness in the Future

    Science.gov (United States)

    1974-07-01

    tl tSOO /(- Wifi »«•« ’»/».C4 on •«-., V t%-y 15 that can be recruited into the Navy--how the Navy uses them will likely undergo some...out in an area. These signs include more trash on the streets, more people hanging around and so forth. On the ship it would be useful to find

  16. Intervjuu James Corneriga = Interview with James Corner / James Corner ; interv. Andres Sevtshuk

    Index Scriptorium Estoniae

    Corner, James

    2006-01-01

    Büroo Field Operations maastikuarhitekt ning Pennsylvania Ülikooli maastikuarhitektuuri osakonna juhataja James Corner oma büroost, maastikust kui "instrumendist", postindustriaalsete aladega seotud projektidest (New Yorgi High Line'i muutmine pargiks ja promenaadiks), tööst suuremahuliste maastikega (Fresh Kills'i soo, endise prügila muutmine pargialaks), maastikuarhitektuurist ja linnakujundusest (maastiku urbanism), õpetamise tähtsusest oma töös ja maastikuarhitektuuri ideede arendamisel. Bibl. lk. 24

  17. Kolme näoga Pädaste häärber / Jana Rand

    Index Scriptorium Estoniae

    Rand, Jana, 1963-

    2008-01-01

    Pädaste mõisa renoveeritud peahoonest. Mõisa ajaloost ja omanikest. Kommenteerib Pädaste mõisa omanik ja sisekujundaja Imre Sooäär, kelle kavandatud on ka hulk uuemat puitmööblit. Joonised aitas teha Kärt Kukkur. Restorani laes on šveitsi kunstniku Heinz Juleni loodud lühter. 12 värv. vaadet

  18. Saadikud annavad aru, kas ja kuidas nende palga kallale minna

    Index Scriptorium Estoniae

    2008-01-01

    Ilmunud ka: Postimees : na russkom jazõke 12. märts lk. 2. Riigikogu liikmete vastused küsimustele palga suuruse ja palgasüsteemi muutmise kohta. Lisa: Seisukohti jaganud riigikogulased. Postimees : na russkom jazõke küsimustele vastavad: Villu Reiljan, Jürgen Ligi, Imre Sooäär, Tatjana Muravjova, Evelyn Sepp, Olga Sõtnik, Vladimir Vellman, Jüri Tamm, Peeter Kreitzberg, Aleksei Lotman, Toomas Tõniste, Mart Nutt

  19. Editorial Comments/ Redaksionele Kommentaar

    Directory of Open Access Journals (Sweden)

    Marie Poggenpoel

    2006-11-01

    Full Text Available This spring edition of Health SA Gesondheid is as lively and colourful as the green leaves and blossoms that signals new life in nature. Opsomming Hierdie lente uitgawe van Health SA Gesondheid is net so lewendig en kleurvol soos die groen blare en bloeisels wat die nuwe lewe in die natuur aankondig. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  20. "Ikka öeldakse : tõde ja õigus ..." / Siiri Ushakova

    Index Scriptorium Estoniae

    Ushakova, Siiri

    2005-01-01

    6. aug. esietendus Alatskivi Hirveaias lavastus "Kus mägi, seal mõis, kus küngas, seal kõrts, talud soo ja raba sees". Idee autor Ülo Must, stsenarist ja lavastaja Reet Kruup. Esitas Alatskivi näitetrupp. Näidend kajastab sündmust, mis leidis aset Alatskivi mõisas 1905. aasta 2. märtsil

  1. A case report of suicidal behavior related to subclinical hyperthyroidism

    OpenAIRE

    Jeong, Jong-Hyun; Joo,Soo-Hyun; Hong,Seung-Chul

    2014-01-01

    Soo-Hyun Joo, Jong-Hyun Jeong, Seung-Chul HongDepartment of Psychiatry, St Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, KoreaAbstract: Abnormalities in thyroid function are associated with many psychiatric symptoms. We present a report of a 15-year-old girl who was admitted to the psychiatry inpatient unit with symptoms of suicidal behavior, irritability, and impulsivity. One year previously, she had become more short-tempered, and had started to c...

  2. Siim Nestor soovitab : Wicked Beat. President of Funk. Muuseumiööl. Springz Bashmendil / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2002-01-01

    16. mail toimub Emajõe äärses klubis Atlantis Eesti esimene nu-skool breaks õhtu Wicked Beat, kus peaesinejaks on DJ ja produtsent Databass (plaadifirma Freakaboom "juhatuse esimees" Justin Owen). 18. mail house-muusika pidu Tartus muusikagaleriis Damtan Dance. 17. mai ööl Rotermanni soolalaos triod: 1. Riho Sibul, Jaak Sooäär ja Raul Saaremets ning 2. Tõnis Leemets, Robert Jürjendal ja Aivar Tõnso. 17. mail Von Krahlis Dj Dr. Koit

  3. Ghosts in the nursery: a case study of the maternal representations of a woman who killed her baby

    Directory of Open Access Journals (Sweden)

    A Gous

    2005-11-01

    Full Text Available The maternal representations as described by Stern (1995:171-190 are used in an extreme case to illustrate the link between depression and pathogenic maternal representations. Opsomming Die moedervoorstellings soos dit deur Stern (1995:171-190 beskryf word, word in ‘n ekstreme geval gebruik om die verband tussen depressie en patogene moedervoorstellings aan te toon. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  4. Mediamonitering in die bestuur van korporatiewe beeld

    OpenAIRE

    2012-01-01

    M.Comm. Die waarde van hierdie ondersoek hou verband met die bemarking van 'n onderneming en die handhawing van 'n mededingende voordeel deur die projektering van 'n positiewe beeld (Anon., 1995a:92; Bateman & Zeithaml, 1993:75; Caminiti, 1992:50; Kotler & Armstrong, 1991:240). Hierdie aspek neem toe in belangrikheid soos wat die besigheidsmilieu in Suid-Afrika verander, veral wat betref die toetrede van buitelandse maatskappye tot die Suid-Afrikaanse mark.

  5. Download this PDF file

    African Journals Online (AJOL)

    Tom

    vrou uit die Viëtnamese adelstand te wys. In die vorm van “'n briefie aan Breyten” verwelkom die redakteur van Rapport (7.1.73) die digter en vertel hom hoe nodig die land hom as digter het: Verskoon asseblief die vleitaal, maar jy weet ons het glad te min manne soos jy. In 'n hele geslag lewer ons soms nie eens een man.

  6. 'n Eksploratiewe ondersoek na adolessente se internetgebruik en die identifisering van moontlike risikofaktore ten opsigte van hulle psigososiale welstand

    OpenAIRE

    Van Der Merwe, Petro; Jansen, Cecelia

    2015-01-01

    Nuwe digitale media, soos die internet en selfone, het 'n integrerende deel van adolessente se lewens geword. Die doel van die ondersoek waarop hierdie artikel gebaseer is, is om te bepaal watter uitwerking adolessente se gebruik van hierdie media op hulle sielkundige welstand en vlak van sosiale aanpassing het. Die betrokke hoofargument is dat kommunikasie deur middel van hierdie media ten koste van belangrike sosiale interaksie in die ware lewe plaasvind - interaksie wat noodsaaklik is om g...

  7. Raamaturott pääses lahti Tartu Loodusmajja / Andrus Okas

    Index Scriptorium Estoniae

    Okas, Andrus

    2014-01-01

    Loodusteemalisi raamatuid ja lauamängu tutvustab Andrus Okas Tartu Loodusmajast: Marvet, Ann. Metsa-, soo- ja niiduaabits : Eesti taimekoosluste määraja (Tallinn : Varrak, 2014). Vilbaste, Kristel. Jõhvikas (Tallinn : Varrak, 2014). Hermann, Elo; Nelk, Marge. Eesti lindude värviraamat. I osa Eesti ([Tartu] : Eesti Ornitoloogiaühing, 2014). Hermann, Elo; Nelk, Marge. Linnumäng : kümme kaardimängu lindude tundmaõppimiseks ([Tartu] : Eesti Ornitoloogiaühing, 2014)

  8. S. DR. O. NoREL, /iei Ge&e

    African Journals Online (AJOL)

    Test

    maal beskaamd, dikwels opgehef en getroos. Ek wys uit baie bladsye bv. op die ontleding van Jakob se gebed, Gen. 32 :9 vv. soos op bl. 92 vv. gegee, van Jesaja 63:14 — 64:12 op bl. 123 vv.; op die uit nemende verklaring van die Bybelse voorstelling van die ken van God, bl. 176 v.; op die treffende karakterisering van ...

  9. 17 Resensies 03.pmd

    African Journals Online (AJOL)

    Tienie01

    15 Jun 2006 ... rom@n in 1999. Met Miskruier word die ver- haal van Suid-Afrika in 2009 vertel deur die oë van die joernalis Braam Fourie. Die hoofkarakter leef in 'n Suid-Afrika wat tekens van geweld ... Die Virus se “aanrol” (soos 'n miskruier wat mis aanrol) .... en die kinders en Brandon en Johnny is bloot slagoffers van ...

  10. 'n Evaluering van die 6M-Simulasie opleidingkursus vir oningewyde swart werkers

    Directory of Open Access Journals (Sweden)

    R. van Niekerk

    1984-11-01

    'n Evaluering van die 6M-Simulasie Opleidingskursus word bespreek met verwysing na die bemeestering van kursusinhoud, die invloed van opleiding op werkprestasie en reaksie van kursusgangers. Resultate dui op 'n beduidende toename in kennis ongeag tussenkomende veranderlikes soos ouderdom, opvoedkundige kwalifikasies, jare diens, huistaal, geboorteplek en werkkategorie. 'n Positiewe reaksie op 34 vrae wat verband hou met die werksituasie, en op die kursusinhoud en opleidingstegnieke word ook gerapporteer.

  11. Die Romeinse nastrewing van onsterflikheid deur middel van memoria

    Directory of Open Access Journals (Sweden)

    D. R. Fouché

    1985-05-01

    Full Text Available Benewens die omvangryke en nasionale manifestasies van die oorspronklike onsterflikheidsgedagte in die Romeinse gemeenskap, vind ons by die Romein op kleiner skaal in groepe of indiwidueel ’n strewe na onsterflikheid langs die weg van memoria. Soos aangetoon sal word, verskil die pogings van die verskillende groepe radikaal van mekaar, hoewel die strewe en einddoel dieselfde bly, naamlik om deur die daarstelling van memoria op die gebied van woord of daad onsterflikheid te bekom.

  12. “Wolmerk” (18) openbaar 'n direkte en liggaamlike ervaring van die ...

    African Journals Online (AJOL)

    8 Apr 2016 ... hemp” (43) “Tabula rasa” (46) “Vers kind” (47) en “Digterspel” (48). Reeds uit die programgedig van die bundel . “Laaste saluut” (11) blyk dat gepoog word om “vervalle” wêrelde soos dié van die standbeeld van 'n soldaat deur taal te preserveer. Die gedig “waar vind jy taal” (45) bevraagteken ...

  13. Hydrological influences on long-term gas flow trends at locations in the Vogtland/NW Bohemian seismic region (German-Czech border

    Directory of Open Access Journals (Sweden)

    J. Heinicke

    2007-06-01

    Full Text Available One of the typical methods for the identification of seismo-hydrological effects is to monitor changes in the free gas flow throughout springs or mofettes. For several years, the gas flow regime of mineral springs at Bad Brambach (Germany and mofettes in the Nature Park Soos (Czech Republic and its dependence on hydro-/meteorological parameters have been studied. The mineral spring ‘Wettinquelle’, Bad Brambach, is a well-known seismo- hydrologically sensitive location for swarmquakes at a special epicentral area of NW Bohemia. Since 2000, a slight upward trend in the gas flow of three Bad Brambach mineral springs has been observed, which became stronger after the ‘Eisenquelle’ spring capture reconstruction (winter 2003/2004. Similar behaviour could be detected at a mofette in Soos. The results correspond to a 3He/4He mantle ratio increase in gases at mofettes in the Cheb Basin (CZ traced by other authors for more than 12 years, and could give hints for a higher degassing activity of the magma body below that area. Common and special properties in the degassing regimes of the Bad Brambach and Soos locations are discussed. It is demonstrated that the long-term gas flow trend was interrupted in 2003 because of very low groundwater levels. This effect was amplified by the artificial groundwater lowering during the ‘Eisenquelle’ spring capture reconstruction.

  14. NANOTECHNOLOGY, NANOMEDICINE; ETHICAL ASPECTS.

    Science.gov (United States)

    Gökçay, Banu; Arda, Berna

    2015-01-01

    Nanotechnology is a field that we often hear of its name nowadays. Altough what we know about it is soo poor, we admire this field of technlogy, moreover some societies even argues that nanotechnology will cause second endustrial revolution. In addition, nanotechnology makes our basic scientific knowledge upside down and is soo powerfull that it is potent in nearly every scientific field. Thereby, it is imposible to say that nanotechnology; which is soo effective on human and human life; will not cause social and ethical outcomes. In general, the definition of nanotechnology is the reconfiguration of nanomaterials by human; there also are different definitions according to the history of nanotechnology and different point of views. First of all, in comparison to the other tehnology fields, what is the cause of excellence of nanotechnology, what human can do is to foresee the advantages and disadvantages of it, what are the roles of developed and developping countries for the progression of nanotechnology, what is the attitude of nanoethics and what is view of global politics to nanotechological research according to international regulations are all the focus of interests of this study. Last but not least, our apprehension capacity of nanotechnology, our style of adoption and evaluation of it and the way that how we locate nanotechnology in our lifes and ethical values are the other focus of interests.

  15. Characteristics of porous zirconia coated with hydroxyapatite as ...

    Indian Academy of Sciences (India)

    TECS

    Zirconia; porosity; hydroxyapatite; coating; compressive strength. 1. Introduction. A lot of .... typically from 300–500 μm, estimated from the SEM images. Thus, the .... Kim H W, Georgiou F, Knowles J C, Koh Y H and Kim H E. 2004 Biomaterials ...

  16. Compassion and Curiosity - TCGA

    Science.gov (United States)

    William Kim, M.D., is motivated by two things: compassion and curiosity. Dr. Kim has taken these dual motivations and created a career in which he cares directly for patients and spearheads research that may lead to improved treatment options.

  17. Determination of antidepressant activity of Cyperus rotundus L ...

    African Journals Online (AJOL)

    Tropical Journal of Pharmaceutical Research April 2017; 16 (4): 867-871 ... 1Shandong University School of Medicine, Jinan, 250012, 2Department of Psychology, People's Hospital of Linyi City, Linyi,. 276003 ..... Academic Press, 1977: 692-698. 8. Porsolt RD, Bertin A ... Lim DW, Jung JW, Park JH, Baek NI, Kim YT, Kim IH,.

  18. Studies on dehydrogenation of cyclohexanol to cyclohexanone over ...

    Indian Academy of Sciences (India)

    B SRIDEVI

    cGovernment College for Women, Osmania University, Koti, Hyderabad, ... MS received 12 September 2016; revised 22 February 2017; accepted 28 ..... Burri D R, Jun K W, Kim Y H, Kim J M, Park S E .... troscopy (New York: Plenum Press).

  19. Kidney injury molecule-1 in renal disease

    NARCIS (Netherlands)

    Waanders, Femke; van Timmeren, Mirjan M.; Stegeman, Coen A.; Bakker, Stephan J. L.; van Goor, Harry

    Kidney injury molecule-1 (KIM-1) is a marker for renal proximal tubular damage, the hallmark of virtually all proteinuric, toxic and ischaemic kidney diseases. KIM-1 has gained increasing interest because of its possible pathophysiological role in modulating tubular damage and repair. In this

  20. Effect of Renin-Angiotensin-Aidosterone System Inhibition, Dietary Sodium Restriction, and/or Diuretics on Urinary Kidney Injury Molecule 1 Excretion in Nondiabetic Proteinuric Kidney Disease : A Post Hoc Analysis of a Randomized Controlled Trial

    NARCIS (Netherlands)

    Waanders, Femke; Vaidya, Vishal S.; van Goor, Harry; Leuvenink, Henri; Damman, Kevin; Hamming, Inge; Bonventre, Joseph V.; Vogt, Liffert; Navis, Gerjan

    Background: Tubulointerstitial damage plays an important role in chronic kidney disease (CKD) with proteinuria. Urinary kidney injury molecule 1 (KIM-1) reflects tubular KIM-1 and is considered a sensitive biomarker for early tubular damage. We hypothesized that a decrease in proteinuria by using

  1. Emissive lead(II) benzenedicarboxylate metal-organic frameworks

    Indian Academy of Sciences (India)

    Abdul Malik P Peedikakkal

    2018-04-16

    Apr 16, 2018 ... Jang E, Jun S, Jang H, Lim J, Kim B and Kim Y 2010. White-light-emitting ... 2837; (b) Li Y-F, Wang D, Liao Z, Kang Y, Ding. W-H, Zheng X-J, Jin L-P 2016 .... Zuo J-L and Zhou H-C 2007 Synthesis and Characteri- zations of a ...

  2. Hydrophilic Cucurbit[7]uril-Pseudorotaxane-Anchored-Monolayer-Protected Gold Nanorods

    Science.gov (United States)

    2013-03-20

    FULL PAPER DOI:10.1002/ejic.201300010 Hydrophilic Cucurbit[7]uril-Pseudorotaxane-Anchored- Monolayer-Protected Gold Nanorods Xiang Ma,[a] Yuhua Xue... Cao , Q. Wang, H. Tian, Chem. Commun. 2011, 47, 3559–3561. [8] a) I. Hwang, K. Baek, M. Jung, Y. Kim, K. M. Park, D. W. Lee, N. Selvapalam, K. Kim, J. Am

  3. Chemical Composition and Anti-Biofilm Activity of Burdock (Arctium ...

    African Journals Online (AJOL)

    formation for cultures treated with burdock leaf fraction, thus confirming the inhibitory efficiency of .... subjected three times to 1 min of sonication ..... 15. Lee K-H, Kim B-S, KeumK-S, Yu H-H, Kim Y-H. Essential. Oil of Curcuma longa Inhibits ...

  4. Bifunctional xylanases and their potential use in biotechnology

    Digital Repository Service at National Institute of Oceanography (India)

    Khandeparker, R.; Numan, M.Th.

    . J Chromatography 919:389–394 33. Hong SY, Lee JS, Cho KM, Math RK, Kim YH, Hong SJ, Cho YU, Kim H, Yun HD (2006) Assembling a novel bifunctional cel- lulase–xylanase from Thermotoga maritima by end-to-end fusion. Biotechnol Lett 28:1857–1862 34...

  5. Efficacy of sodium bicarbonate as anaesthetic for yellow seahorse, Hippocampus kuda (Bleeker, 1852)

    Digital Repository Service at National Institute of Oceanography (India)

    Pawar, H.B.; Ingole, B.S.; Sreepada, R.A.

    .J., Ryu, B.M., Kim, M.M., Kim, S.K., 2008. Free Radical and Reactive Oxygen Species Scavenging Activities of the Extracts from Seahorse, Hippocampus kuda, Bleeler. Biotechnol. Bioprocess Eng. 13, 705- 715. 20. Ross, L.G., Ross, B., 1999. Anaesthetic...

  6. Frames and extension problems I

    DEFF Research Database (Denmark)

    Christensen, Ole

    2014-01-01

    In this article we present a short survey of frame theory in Hilbert spaces. We discuss Gabor frames and wavelet frames and set the stage for a discussion of various extension principles; this will be presented in the article Frames and extension problems II (joint with H.O. Kim and R.Y. Kim)....

  7. Gene expression profiles in adenosine-treated human mast cells ...

    African Journals Online (AJOL)

    Gene expression profiles in adenosine-treated human mast cells. ... SW Kang, JE Jeong, CH Kim, SH Choi, SH Chae, SA Jun, HJ Cha, JH Kim, YM Lee, YS ... beta 4, ring finger protein, high-mobility group, calmodulin 2, RAN binding protein, ...

  8. Gender-divergent expression of lipid and bile acid metabolism ...

    Indian Academy of Sciences (India)

    Yuji Tanaka

    2018-04-10

    Apr 10, 2018 ... mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A. J. Nutr. ... Pozo Rosado P and. Garcıa López D 2011 Positive effects of physical exercise on ... Diabetes 59 1899–1905. Kim J, Kim J and Kwon ...

  9. Synthesis of Nitrogen-doped Carbon Nanotubes with Layered ...

    African Journals Online (AJOL)

    NICO

    Nitrogen-doped carbon nanotubes (CNx) were synthesized by the catalytic chemical vapour deposition ... dispersed metal nanoparticles over oxide matrices can be obtained ..... 18 S.Y. Kim, J. Lee, C.W. Na, J. Park, K. Seo and B. Kim, Chem.

  10. Institutional Change through Assessment: Contrasting Case Studies

    Science.gov (United States)

    Deess, E. Pierre; Elliot, Norbert

    2009-01-01

    The framework for understanding the management difference is neatly captured by the "red ocean" and "blue ocean" strategies described by W. Chan Kim and Renee Mauborgne in "Blue Ocean Strategy" (Kim & Mauborgne, 2004). In the original, the terms refer to alternative market strategies. Red ocean means competition in a market defined by a zero sum…

  11. Analysis of the early response to chemotherapy in lung cancer using ...

    African Journals Online (AJOL)

    Histogram analysis based on the whole-tumor ROI method is preferred for .... displayed on the y-axis. The histogram ... Wang H, Fei B. Diffusion-weighted MRI for monitoring ... Ahn SJ, Choi SH, Kim YJ, Kim KG, Sohn CH, Han MH,. Chang KH ...

  12. Pt-Pd nanoelectrocatalyst of ultralow Pt content for the oxidation of ...

    Indian Academy of Sciences (India)

    formic acid oxidation on Pt4Pd96 nanoparticles. Keywords. ..... Choi J H, Jeong K J, Dong Y, Han J, Lim T H, Lee J S ... Rhee C K, Kim B J, Ham C, Kim Y J, Song K and Kwon ... Wang R, Liao S and Ji S 2008 J. Power Sources 180 205. 18.

  13. Symplocaceae

    African Journals Online (AJOL)

    There are only few reports on the chemical composition of ... However, literature searches have shown no report on ..... Jiang J, Feng Z, Wang Y, Zhang P. New phenolics from the roots of ... Song J, Li N, Xia Y, Gao Z, Zou SF, Kong L, Yao YJ, Jiao. YN, Yan YH ... Han YH, Kee JY, Park J, Kim HL, Jeong MY, Kim DS,. Jeon YD ...

  14. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 112; Issue 2. Sums of Two Polynomials with Each having Real Zeros Symmetric with the Other. Seon-Hong Kim. Volume 112 Issue 2 ... Author Affiliations. Seon-Hong Kim1. School of Mathematical Sciences, Seoul National University, Seoul 151-742, Korea ...

  15. Effects of glycyrrhizin pre-treatment on transient ischemic brain ...

    African Journals Online (AJOL)

    Effects of glycyrrhizin pre-treatment on transient ischemic brain injury in mice. ... on transient ischemic brain injury in mice. Chiyeon Lim, Sehyun Lim, Young-Jun Lee, Bokcheul Kong, Byoungho Lee, Chang-Hyun Kim, Buyeo Kim, Suin Cho ... induced brain damage. Keywords: Glycyrrhizin, licorice, stroke, apoptosis ...

  16. Creating Learning: A Korean Drummer's Lifelong Quest to Be the Best

    Science.gov (United States)

    Kang, Dae Joong

    2010-01-01

    In this article, the author interrogates how one famous Korean traditional drummer Mr. Myong-hwan Kim's lifelong learning is affected by the sociocultural and historical context as it contributes to the construction of his life. This article analyzed an oral history book that contains Mr. Kim's interview narratives since he died 20 years ago.…

  17. Barrier Engineered Quantum Dot Infrared Photodetectors

    Science.gov (United States)

    2015-06-01

    251108. 6. Barve, Ajit V., Saumya Sengupta, Jun Oh Kim, John Montoya , Brianna Klein, Mohammad Ali Shirazi, Marziyeh Zamiri et al., "Barrier selection... H . Kim, Z-B. Tian, and Sanjay Krishna. "Barrier Engineered Infrared Photodetectors Based on Type-II InAs/GaSb Strained Layer Superlattices." (2013

  18. Assessment of Mindfulness with the French Version of the Kentucky Inventory of Mindfulness Skills in Community and Borderline Personality Disorder Samples

    Science.gov (United States)

    Nicastro, Rosetta; Jermann, Francoise; Bondolfi, Guido; McQuillan, Annabel

    2010-01-01

    This article explores mindfulness skills in community and borderline personality disorder (BPD) samples. Study 1 includes 173 community volunteers and explores the psychometric properties of the French version of the Kentucky Inventory of Mindfulness Skills (KIMS). Study 2 explores the KIMS factor structure in 130 BPD patients and compares KIMS…

  19. African Journal of Biotechnology - Vol 11, No 48 (2012)

    African Journals Online (AJOL)

    ... brain aromatase-induction of monosodium glutamate in estrogen-responsive mosaic transgenic zebra fish Danio rerio · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Tamer Said Abdelkader, Chang Seo-Na, Kim Tae-Hyun, Song Juha, Kim Dongso, Jae-Hak Park ...

  20. Expression of porcine myosin heavy chain 1 gene in Berkshire loins ...

    African Journals Online (AJOL)

    Expression of porcine myosin heavy chain 1 gene in Berkshire loins with a high pH24 value. Jin Hun Kang, Woo Young Bang, Eun Jung Kwon, Yong Hwa Lee, Da Hye Park, Eun Seok Cho, Min Ji Kim, Jong-Soon Choi, Hwa Chun Park, Beom Young Park, Chul Wook Kim ...

  1. We Are Going to Have to Imagine Our Way Out of This One...

    DEFF Research Database (Denmark)

    De Cock, Christian

    2018-01-01

    Book reviews of: New York 2140. Kim Stanley Robinson. London: Orbit, 2017. 624 pp. £20 (hbk). ISBN 9780356508757 Science in the Capital trilogy: Forty Signs of Rain (2004 – ASIN: B01KTJYB5G), Fifty Degrees Below (2005 – ASIN: B00BS06T88), Sixty Days & Counting (2007 – ASIN: B00BS06T8I) – Kim...

  2. Effect of aging on copper nanoparticles synthesized by pulsed laser ...

    Indian Academy of Sciences (India)

    Administrator

    2009-06-23

    Jun 23, 2009 ... Hsieh C T, Chen J M, Lin H H and Shih H C 2003 Appl. Phys. Lett. 83 3383. Hsieh J H, Kuo P W, Peng K C, Liu S J, Hsueh J D and Chang. S C 2008 Thin ... Jung J H, Kim T W, Song M S, Kim Y H and Yoo K H 2007. J. Appl.

  3. The View From Pyongyang: Prospects for Survival in the 21st Century

    National Research Council Canada - National Science Library

    Neky, Patrick

    2000-01-01

    .... What course will Kim Jong II choose for himself and his country? The political structure of the DPRK has been deliberately crafted to focus all meaningful power and decision-making on the person of Kim Jong II and retains no ability to reform itself...

  4. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (81st, Baltimore, Maryland, August 5-8, 1998). Advertising.

    Science.gov (United States)

    Association for Education in Journalism and Mass Communication.

    The Advertising section of the Proceedings contains the following 18 papers: "The Birth of Adwatches: Political Advertising Becomes Front-Page News" (Jennifer Greer); "A Cross-Cultural Comparison of the Effects of Source Credibility on Attitudes and Behavioral Intentions" (Kak Yoon, Choong Hyun Kim, and Min-Sun Kim);…

  5. Strain-Induced Pseudo-Magnetic Fields Greater Than 300 Tesla in Graphene Nanobubbles

    Science.gov (United States)

    2010-07-30

    H. L. Stormer , P. Kim, Nature 438, 201 (2005). 8. K. S. Novoselov et al., Nature 438, 197 (2005). 9. K. I. Bolotin, F. Ghahari, M. D. Shulman, H. L... Stormer , P. Kim, Nature 462, 196 (2009). 10. X. Du, I. Skachko, F. Duerr, A. Luican, E. Y. Andrei, Nature 462, 192 (2009). 11. V. M. Pereira, A. H

  6. Electronic Struture and Quantum Effects of Thin Metal Film Systems Based on Silicon Carbide

    Science.gov (United States)

    2013-05-01

    324, 924 (2009). [33] K. S. Novoselov et al., Nature (London) 438, 197 (2005). [34] Y. Zhang, Y.-W. Tan, H. L. Stormer , and P. Kim, Nature (London...Zhang, Y.-W. Tan, H. L. Stormer , and P. Kim, Nature (London) 438, 201 (2005). [6] K. S. Novoselov et al., Nature Phys. 2, 177 (2006). [7] E. McCann and V

  7. Electron Transport in Graphene From a Diffusion-Drift Perspective

    Science.gov (United States)

    2010-02-24

    Tung, M.E. Schwartz, M. Takita, Y.-J. Wang, P. Kim, and H.L. Stormer , “Cyclotron resonance in bilayer graphene,” Phys. Rev. Lett. 100, 087403 (2008...Dec. 2004. [3] K. I. Bolotin, K. J. Sikes, Z. Jiang, M. Klima, G. Fudenberg, J. Hone, P. Kim, and H. L. Stormer , “Ultrahigh electron mobility in

  8. Snapshots from a leading eco-city

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2009-01-01

    The government of Singapore wants to make Singapore the leading Eco-city in Asia. Professor Kim Chuan Goh explains why this might be an achievable goal.......The government of Singapore wants to make Singapore the leading Eco-city in Asia. Professor Kim Chuan Goh explains why this might be an achievable goal....

  9. Gas sensing application of nanocrystalline zinc oxide thin films ...

    Indian Academy of Sciences (India)

    ZnO is a material with a variety of potential applications such as electronics,7 photonics,8 acoustics,9 TCO layer in ..... change, as a response to surface chemical reactions with environmental gases. ..... Wang D, Chu X and Gong M 2007 Nanotechnology 18 185601. 79. Kim K M, Hyun-Mook Jeong, Hae-Ryong Kim, Kwon-Il ...

  10. Contribution to thermodynamics and kinetics of argon, krypton and xenon at very low temperatures; Contribution a l'etude thermodynamique et cinetique de l'argon, du krypton et du xenon aux tres basses temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Levenson, L L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    A critical analysis of the main theories of condensation, which are due to Zwanzig, Cabrera, Mc Caroll and Ehrlich, Wanlass, Armand, and Yu and Soo, is made. A condensation coefficient equal to unity is expected from these theories, except Armand and Yu and Soo, when the temperature of the gas impinging on its own solid phase is equal or less than 300 K. Using a resonating quartz microbalance the sensitivity of which is 10{sup -9} g. cm{sup 2} the experimental data agree with these theories when the temperature of the solid is less than 20 K. However the agreement must be interpreted for the more sophisticated theories of Armand and Yu and Soo. Regarding the sublimation of the rare gases one is faced with the theories of Salter, Eyring, Goodman and Armand. Within an order of magnitude the experimental data given here agree with the expected values. Moreover Armand theory is able to give the physical meaning of the observed results for argon sublimation from a krypton or a xenon crystalline substrate: localized modes of surface vibration occur. The relaxation time for the thermalization of the argon deposit is found greater than twelve hours at 25 K. (author) [French] Ce travail inclut l'etude critique des principales theories de la condensation dues a Zwanzig, Cabrera, Mc Caroll et Ehrlich, Wanlass, Armand, et Yu et Soo. Ces theories, sauf les deux dernieres, prevoient un coefficient de condensation egal a 1 lorsque le gaz incident sur son propre solide a une temperature inferieure ou egale a 300 K. Les mesures effectuees a l'aide d'une microbalance a quarz resonnant sensible a 10{sup -9} g. cm{sup 2} ont confirme ces theories dans le cas ou la temperature du solide est inferieure a 20 K. Cet accord doit cependant etre interprete pour les theories plus completes d'Armand d'une part, Yu et Soo d'autre part. Pour la sublimation des gaz rares on se trouve en presence des theories de Salter, Eyring, Goodman et Armand. Leurs previsions sont en accord, a un ordre de

  11. Kilovoltage Intrafraction Monitoring for Prostate Intensity Modulated Arc Therapy: First Clinical Results

    International Nuclear Information System (INIS)

    Ng, Jin Aun; Booth, Jeremy T.; Poulsen, Per R.; Fledelius, Walther; Worm, Esben Schjødt; Eade, Thomas; Hegi, Fiona; Kneebone, Andrew; Kuncic, Zdenka; Keall, Paul J.

    2012-01-01

    Purpose: Most linear accelerators purchased today are equipped with a gantry-mounted kilovoltage X-ray imager which is typically used for patient imaging prior to therapy. A novel application of the X-ray system is kilovoltage intrafraction monitoring (KIM), in which the 3-dimensional (3D) tumor position is determined during treatment. In this paper, we report on the first use of KIM in a prospective clinical study of prostate cancer patients undergoing intensity modulated arc therapy (IMAT). Methods and Materials: Ten prostate cancer patients with implanted fiducial markers undergoing conventionally fractionated IMAT (RapidArc) were enrolled in an ethics-approved study of KIM. KIM involves acquiring kV images as the gantry rotates around the patient during treatment. Post-treatment, markers in these images were segmented to obtain 2D positions. From the 2D positions, a maximum likelihood estimation of a probability density function was used to obtain 3D prostate trajectories. The trajectories were analyzed to determine the motion type and the percentage of time the prostate was displaced ≥3, 5, 7, and 10 mm. Independent verification of KIM positional accuracy was performed using kV/MV triangulation. Results: KIM was performed for 268 fractions. Various prostate trajectories were observed (ie, continuous target drift, transient excursion, stable target position, persistent excursion, high-frequency excursions, and erratic behavior). For all patients, 3D displacements of ≥3, 5, 7, and 10 mm were observed 5.6%, 2.2%, 0.7% and 0.4% of the time, respectively. The average systematic accuracy of KIM was measured at 0.46 mm. Conclusions: KIM for prostate IMAT was successfully implemented clinically for the first time. Key advantages of this method are (1) submillimeter accuracy, (2) widespread applicability, and (3) a low barrier to clinical implementation. A disadvantage is that KIM delivers additional imaging dose to the patient.

  12. North Korean Policy Elites

    Science.gov (United States)

    2004-06-01

    by Kim’s former Japanese chef , Kenji Fujimoto, reveal that Kim could get just about anything he wanted in his personal life, from foreign delicacies...for his table to Japanese jet skis and Sony home electronics.9 Likewise, the account of Yi Nam-oak (Li Nam-ok), who grew up as a companion to Kim’s...title Kin Seinichi no Ryoryinin [Kim Jong-il’s Chef ], Tokyo: Fusosha, 2003. The title of the Korean edition is Kim Jong-il ui yorisa. FBIS translated

  13. Quality assurance for the clinical implementation of kilovoltage intrafraction monitoring for prostate cancer VMAT

    DEFF Research Database (Denmark)

    Ng, J. A.; Booth, J. T.; O'Brien, R. T.

    2014-01-01

    is being piloted in a clinical trial for prostate cancer patients treated with VMAT (NCT01742403). The purpose of this work was to develop clinical process and quality assurance (QA) practices for the clinical implementation of KIM. Methods: Informed by and adapting existing guideline documents from other...... real-time monitoring systems, KIM-specific QA practices were developed. The following five KIM-specific QA tests were included: (1) static localization accuracy, (2) dynamic localization accuracy, (3) treatment interruption accuracy, (4) latency measurement, and (5) clinical conditions accuracy. Tests...... developed and implemented for prostate cancer VMAT....

  14. A Highly Responsive Silicon Nanowire/Amplifier MOSFET Hybrid Biosensor

    Science.gov (United States)

    2015-07-21

    Hybrid Biosensor Jieun Lee1,2, Jaeman Jang1, Bongsik Choi1, Jinsu Yoon1, Jee-Yeon Kim3, Yang-Kyu Choi3, Dong Myong Kim1, Dae Hwan Kim1 & Sung-Jin Choi1...This study demonstrates a hybrid biosensor comprised of a silicon nanowire (SiNW) integrated with an amplifier MOSFET to improve the current response...of field-effect-transistor (FET)-based biosensors . The hybrid biosensor is fabricated using conventional CMOS technology, which has the potential

  15. Mitigating crystallization of saturated FAMEs in biodiesel 6: The binary phase behavior of 1, 2-dioleoyl-3-stearoyl sn-glycerol – Methyl stearate

    International Nuclear Information System (INIS)

    Mohanan, Athira; Bouzidi, Laziz; Narine, Suresh S.

    2016-01-01

    The derivatives of vegetable oils with specific chemical structures, such as TAG (triacylglycerols) having mixed straight and kinked moieties, have proven very effective in lowering the crystallization of biodiesel. SOO (1, 2-dioleoyl-3-stearoyl sn-glycerol)/MeS (methyl stearate) is part of a series of studies of TAG/FAME (fatty acid methyl ester) binary model systems conducted to establish structure–function relationships of lipid-based cold flow improvers in biodiesel with a particular attention to the effect of molecular symmetry in contrast with a previously published study of the OSO (1, 3-dioleoyl-2-stearoyl sn-glycerol)/MeS binary system. The phase behavior of several SOO/MeS mixtures were investigated at different length scales with XRD (X-ray diffraction), DSC (differential scanning calorimetry) and PLM (polarized light microscope). A complete phase diagram including the transformation lines, crystal structure and microstructure was constructed. The solubility behavior was discussed using a simple thermodynamic model based on the Hildebrand equation and pair interactions. The asymmetric position of the oleic moieties of SOO was shown to be crucial in modifying the thermal transformation behavior of MeS. The findings may be used to design effective crystallization modifiers of biodiesel based on particular structural determinants, and underscores the importance of symmetry in such designs. - Highlights: • Effect of symmetry of triglyceride on biodiesel crystallization established. • Complete phase diagram of model triacylglycerol/biodiesel binary system achieved. • Correlation between thermal transitions, crystal structure and microstructure revealed. • Transformation points useful for improving the cold flow of biodiesel identified. • Necessary knowledge gathered to design effective biodiesel cold flow improvers.

  16. Water Quality Evaluation of PET Bottled Water by Mineral Balance in the Northeast Asian Region: A Case Study of South Korea.

    Science.gov (United States)

    Houri, Daisuke; Koo, Chung Mo

    2015-09-01

    The past few years have seen a demand for drinking water in contemporary society with a focus on safety and taste. Mineral water is now marketed as a popular commercial product and, partly due to health concerns, the production. For the study, a comparison was carried out of water samples from 9 types of polyethylene terephthalate (PET) bottled water sold in South Korea as well as from tap water in the cities of Seoul and Chuncheon. These were compared with samples of Japanese PET bottled water in order to determine shared commonalities and identify individual characteristics. To evaluate water quality objectively, we quantified the elements contained in the water samples. Samples were assessed not with the usual sensory evaluation but with the evaluation approach advocated by Hashimoto et al. which employs the Water Index of Taste and the Water Index of Health. The levels of water quality obtained were compared with the "Prerequisites for Tasty Water" and the "Standards for Tasty Water" devised for city water. The PET Bottled water varieties analyzed in this study-Seoksu, Icis, Bong Pyong, Soon Soo 100, Dong Won Saem Mul, GI JANG SOO and DIAMOND-showed the Water Index of Taste ≥ 2.0 and the Water Index of Health ≥ 5.2, which we classified as tasty/healthy water. SamDaSoo and NamiNeral can be classified as tasty water due to their values of the Water Index of Taste ≥ 2.0 and the Water Index of Health water studied here fulfills the "Water Index of Taste," "Water Index of Health," "Standard for Tasty Water" and "Prerequisites for Tasty Water" that Japanese people value for city water. We can conclude that bottled water which meets water quality requirements will be considered good-tasting by a majority of people.

  17. In situ crystallization and transformation kinetics of polymorphic forms of saturated-unsaturated-unsaturated triacylglycerols: 1-palmitoyl-2,3-dioleoyl glycerol, 1-stearoyl-2,3-dioleoyl glycerol, and 1-palmitoyl-2-oleoyl-3-linoleoyl glycerol.

    Science.gov (United States)

    Bayés-García, L; Calvet, T; Cuevas-Diarte, M A; Ueno, S

    2016-07-01

    We examined the influence of dynamic thermal treatment (variation of cooling/heating rates) on the polymorphic crystallization and transformation pathways of 1-palmitoyl-2,3-dioleoyl glycerol (POO), 1-stearoyl-2,3-dioleoyl glycerol (SOO), and 1-palmitoyl-2-oleoyl-3-linoleoyl glycerol (POL), which are major saturated-unsaturated-unsaturated (SUU) triacylglycerols (TAGs) of vegetable oils and animal fats (e.g., palm oil, olive oil, and Iberian ham fat). Using mainly a combination of differential scanning calorimetry (DSC) and synchrotron radiation X-ray diffraction (SR-XRD), we analyzed the polymorphic behavior of TAGs when high (15°Cmin -1 ), intermediate (2°Cmin -1 ), and low (0.5°Cmin -1 ) cooling and heating rates were applied. Multiple polymorphic forms were detected in POO, SOO, and POL (sub-α, α, β' 2 , and β' 1 ). Transient disordered phases, defined as kinetic liquid crystal (KLC) phases, were determined in POO and SOO for the first time. The results demonstrated that more stable forms were directly obtained from the melt by decreasing the cooling rates, whereas less stable forms predominated at high cooling rates, as confirmed in our previous work. Regarding heating rate variation, we confirmed that the nature of the polymorphic transformations observed (solid-state, transformation through KLC phase, or melt-mediation) depended largely on the heating rate. These results were discussed considering the activation energies involved in each process and compared with previous studies on TAGs with different saturated-unsaturated structures (1,3-dioleoyl-2-palmitoylglycerol, 1,3-dipalmitoyl-2-oleoyl-glycerol, trioleoyl glycerol, and 1,2-dioleoyl-3-linoleoyl glycerol). Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. A MODULAR DESIGN OF A WALL-CLIMBING ROBOT AND ITS MECHATRONICS CONTROLLER

    Directory of Open Access Journals (Sweden)

    N.S. Tlale

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: The modular design of a wall-climbing robot, implementing two articulated legs per module (biped robotic modules, is presented in this paper. Modular design improves a wall-climbing robot’s manoeuvrability and flexibility during surface changes or while walking on uneven surfaces. The design of the articulated legs uses four motors to control the posture of the vacuum cups, achieving the best possible contact with the surface. Each leg can contain more than five sensors for effective feedback control, and additional sensors such as gyros, CCD sensors, etc, can be fitted on a module, depending on the robot’s application. As the number of modules used in the design of the robot is increased, the number of actuators and sensors increases exponentially. A distributed mechatronics controller of such systems is presented.

    AFRIKAANSE OPSOMMING: Modulêre ontwerp van 'n muurklim-robot met twee geskarnierde bene per module (twee-benige robotmodules word in hierdie artikel weergegee. Modulêre ontwerp verbeter die muurklim-robot se beweeglikheid en aanpasbaarheid tydens veranderings in die loopvlak of terwyl dit loop op ongelyke oppervlaktes. Ontwerp van geskarnierde bene implementeer vier motors wat die oriëntasie van vakuumsuigdoppe beheer om die bes moontlike kontak met die loopvlak te handhaaf. Elke been kan meer as vyf sensors hê vir doeltreffende terugvoerbeheer, en bykomende sensors soos giroskope, CCD sensors, ens. kan by 'n module gevoeg word soos die toepassing van die robot dit mag vereis. Soos die aantal modules wat in die ontwerp van die robot gebruik word, toeneem, neem die aantal aktiveerders en sensors eksponensiëel toe. 'n Verdeelde megatroniese beheerder van sulke stelsels word aangebied.

  19. Advanced Materials and Processing 2010

    Science.gov (United States)

    Zhang, Yunfeng; Su, Chun Wei; Xia, Hui; Xiao, Pengfei

    2011-06-01

    Strain sensors made from MWNT/polymer nanocomposites / Gang Yin, Ning Hu and Yuan Li -- Shear band evolution and nanostructure formation in titanium by cold rolling / Dengke Yang, Peter D. Hodgson and Cuie Wen -- Biodegradable Mg-Zr-Ca alloys for bone implant materials / Yuncang Li ... [et al.] -- Hydroxyapatite synthesized from nanosized calcium carbonate via hydrothermal method / Yu-Shiang Wu, Wen-Ku Chang and Min Jou -- Modeling of the magnetization process and orthogonal fluxgate sensitivity of ferromagnetic micro-wire arrays / Fan Jie ... [et al.] -- Fabrication of silicon oxide nanowires on Ni coated silicon substrate by simple heating process / Bo Peng and Kwon-Koo Cho -- Deposition of TiOxNy thin films with various nitrogen flow rate: growth behavior and structural properties / S.-J. Cho ... [et al.] -- Observation on photoluminescence evolution in 300 KeV self-ion implanted and annealed silicon / Yu Yang ... [et al.] -- Facile synthesis of lithium niobate from a novel precursor H[symbol] / Meinan Liu ... [et al.] -- Effects of the buffer layers on the adhesion and antimicrobial properties of the amorphous ZrAlNiCuSi films / Pai-Tsung Chiang ... [et al.] -- Fabrication of ZnO nanorods by electrochemical deposition process and its photovoltaic properties / Jin-Hwa Kim ... [et al.] -- Cryogenic resistivities of NbTiAlVTaLax, CoCrFeNiCu and CoCrFeNiAl high entropy alloys / Xiao Yang and Yong Zhang -- Modeling of centrifugal force field and the effect on filling and solidification in centrifugal casting / Wenbin Sheng, Chunxue Ma and Wanli Gu -- Electrochemical properties of TiO[symbol] nanotube arrays film prepared by anodic oxidation / Young-Jin Choi ... [et al.] -- Effect of Ce additions on high temperature properties of Mg-5Sn-3Al-1Zn alloy / Byoung Soo Kang ... [et al.] -- Sono-electroless plating of Ni-Mo-P film / Atsushi Chiba, Masato Kanou and Wen-Chang Wu -- Diameter dependence of giant magneto-impedance effect in co-based melt extracted amorphous

  20. Studies on bare and Mg-doped LiCoO2 as a cathode material for lithium ion batteries

    CSIR Research Space (South Africa)

    Reddy, MV

    2014-05-01

    Full Text Available at ScienceDirect Electrochimica Acta jo ur nal ho me p age: www.elsev ier .com/ locate /e lec tac ta Graphical Abstract Electrochimica Acta xxx (2013) xxx–xxx Studies on Bare and Mg-doped LiCoO2 as a cathode material for Lithium ion Batteries M.V. Reddy... for Lithium ion Batteries M.V. Reddy∗, Thor Wei Jie, Charl J. Jafta, Kenneth I. Ozoemena, Mkhulu K. Mathe, A. Sree Kumaran Nair, Soo Soon Peng, M. Sobri Idris, Geetha Balakrishna, Fabian I. Ezema, B.V.R. Chowdari • Layered compounds, Li...

  1. OBVLADOVANJE STRESA NA DELOVNEM MESTU OPERATERJA V REGIJSKEM CENTRU ZA OBVEŠČANJE

    OpenAIRE

    Piškur, Luka

    2016-01-01

    Hiter življenjski tempo sodobne družbe nas je v zadnjih letih privedel do tega, da ne najdemo kvalitetnega časa sami zase. Poslužujemo se nekvalitetne prehrane, ne najdemo časa za počitek, preplavljajo nas negativne misli in čustva. Tako doma kot na delovnem mestu se soočamo s frustracijami, roki in zahtevami, za katere se večina od nas sploh ne zaveda, kako stresni so. S prepoznavanjem simptomov stresa lahko naredimo prvi korak k temu, da izboljšamo kvaliteto našega življenja. Cilj diplo...

  2. TERT-CLPTM1 locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma

    OpenAIRE

    Lee, Hye Won; Park, Won-Jin; Heo, Yu-Ran; Park, Tae In; Park, Soo Young; Lee, Jae-Ho

    2017-01-01

    Hye Won Lee,1,* Won-Jin Park,2,* Yu-Ran Heo,2 Tae In Park,3 Soo Young Park,4 Jae-Ho Lee2,* 1Department of Pathology, Keimyung University School of Medicine, Daegu, Republic of Korea; 2Department of Anatomy, Keimyung University School of Medicine, Daegu, Republic of Korea; 3Department of Pathology, Kyungpook National University School of Medicine, Daegu, Republic of Korea; 4Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea *T...

  3. ABSENTIZEM IN FLUKTUACIJA V PODJETJU AMZS D.D., PE KRANJ

    OpenAIRE

    Perko, Anja

    2013-01-01

    Absentizem in fluktuacija sta eden od glavnih težav, s katerim se danes soočajo podjetja po vsem svetu, saj prinašata stroške, slabo organizacijsko klimo in nezadovoljstvo zaposlenih. Vse to podjetjem onemogoča, da sledijo svoji realizaciji ciljev in ostanejo konkurenčna ter uspešna na trgu, kar je v teh recesijskih časih še kako pomembno. Zato si mnogi delodajalci v današnjih slabih gospodarskih časih prizadevajo za zmanjšanje absentizma in fluktuacije v njihovih podjetjih, vendar so večinom...

  4. Die partypolitiek en die toekoms van die Afrikaanse volkskultuur

    Directory of Open Access Journals (Sweden)

    A.P. Treurnicht

    1970-03-01

    Full Text Available Reeds in 1853 het die Zuid Afrikaan hom soos volg uitgelaat: „Dis ’n dwaling wat ons reeds meermale bestry het dat ons as Britse onderdane verplig sou wees, om die Britse nasionaliteit ons s’n te maak. Die Kolonis van Hollandse oorsprong kan geen Engelsman word nie, en moet ook geen Nederlander wil wees nie. Wanneer hy weet om sy standpunt te waardeer, dan sal hy as verligte kolonis die grondtrekke van die Engelse volkskarakter met dié van die Nederlandse harmonies leer verenig en daardeur word wat hy as Kapenaar moet word.”

  5. Die nut van kriging in gravitasie-opnames

    Directory of Open Access Journals (Sweden)

    G. J. van Tonder

    1985-03-01

    Full Text Available Ondersoek is ingestel na die gebruik van kriging as hulpmiddel by die gravitasiemetode vir die opsporing van verweerde sones in die dolomitiese gebiede van Suid-Afrika. Na ’n kort bespreking van die basiese beginsels van kriging, word die metode toegepas op die Bouguer-anomaliewaardes, soos waargeneem op ’n deel van die Zuurbekomkompartement. Daar word getoon dat die aantal waarnemingspunte met tot soveel as 90 persent verminder kan word, sonder ’n noemenswaardige verlies van akkuraatheid in die bepaling van die geskatte volumes verweerde dolomiet.

  6. IZBOLJŠANJE PROCESA VZDRŽEVANJA V PODJETJU ELEKTRODE JESENICE D.O.O.

    OpenAIRE

    Filipov, Slobodan

    2016-01-01

    V podjetju Elektrode Jesenice, d. o. o., se soočajo s pomanjkljivim in neučinkovitim vzdrževanjem. Glavni namen diplomskega dela je izboljšanje procesa vzdrževanja v podjetju, saj je trenutno stanje precej neurejeno, učinkovito vzdrževanje pa je eden od pomembnih dejavnikov uspešnosti podjetja. V prvem delu diplomskega dela smo predstavili nekaj načinov vzdrževanja, ki jih podjetja dandanes najpogosteje uporabljajo. Osredotočili smo se na preventivno vzdrževanje in za vlečno-rezalno lini...

  7. ORGANIZACIJA IN TRŽENJE SPLETNE STRANI DNEVNIK.SI

    OpenAIRE

    Blatnik, Mateja

    2011-01-01

    Diplomska naloga obravnava problematiko na področju trženja spletnih strani oziroma problematiko, s katero se dnevno soočamo pri trženju v družbi Dnevnik, d.d. Predvsem menimo, da bi bilo potrebno dati poudarek na izobraževanju, strokovnih kadrih, motivaciji, izoblikovanju strategije in ciljev. Izpostaviti želimo popolnoma nov način tako trženja kot tudi nov način povečanja prodaje oglasnega prostora in s tem tržnega deleža podjetja, ugotoviti dejavnike za doseganje konkurenčne prednosti gled...

  8. NOVOSTI OBDAVČITVE SAMOSTOJNIH PODJETNIKOV

    OpenAIRE

    Sakelšek, Maruša

    2015-01-01

    Čeprav se v Sloveniji in tudi nekaterih drugih državah Evropske Unije že nekaj let soočamo z gospodarsko krizo, je porast novoustanovljenih podjetij vse večji. Cilj vsakega podjetnika je kljub temu uspešno poslovanje, zato je pred ustanovitvijo podjetja pomembno, da preuči vse možnosti – katero vrsto podjetja ustanoviti in katero vrsto obdavčitve izbrati. To je pomembno predvsem zato, ker mnogo novoustanovljenih podjetij propade ravno zaradi nepravilnega in pomanjkljivega planiranja začetka s...

  9. Maaleht soovitab : Superstaarid esinevad Taskus. Monkist "Saaremaa valsini". Muusikapidu pärimusmuusika keskuses. Suvelõpupidu Marina külas. Hortus Musicus esineb Väravatornis

    Index Scriptorium Estoniae

    2008-01-01

    18. sept. esinevad Tartus Tasku moe- ja vaba aja keskuses telekonkursil Eesti otsib Superstaari osalenud Jana Kask ja Arno Suislep ning saate "Kaks takti ette" võitja Margus Vaher. 18. sept. toimub Tallinna Kunstihoones kitarristide Tiit Pauluse ja Jaak Sooääre uue CD esitluskontsert. 19. sept. toimub Viljandi pärimusmuusika keskuses maailmamuusika-pidu. Suvelõpupeol 20. sept. Saarde vallas Grossi järve ääres Marina külas esinevad Virve Köster ja Audru Jõelaevanduse Punt. 20. sept. Tallinnas Väravatornis esineb vanamuusikaansambel Hortus Musicus

  10. Kritiese geletterdheid: Die ontmoeting tussen die Westerse sekularisme en Islamitiese spiritualiteit in geselekteerde romans vir jong volwasseness – 'n benadering

    Directory of Open Access Journals (Sweden)

    Salome Romylos

    2016-11-01

    Full Text Available Hierdie artikel het ten doel om aan te toon dat die geselekteerde romans vir jong volwassenes potensieel kragtige ruimtes kan wees vir die skep van ’n bewustheid en beter begrip van Moslems, Islam, en veral van die dra van sluiers en kopdoeke. Kritiese geletterdheid as ’n metodologie word gebruik om te demonstreer hoe leerders gelei kan word om krities betrokke te raak by tekste. Dit is noodsaaklik, omdat blote oppervlakkennis nie genoeg is wanneer leerders gekonfronteer word met ingewikkelde kwessies soos ras, spiritualiteit en kultuur nie. Westerse televisie, koerante en tydskrifte skilder ’n baie eensydige beeld van Moslems as ’n naatloos homogene groep. Baie jong volwassenes neem aktief deel aan gesprekke op digitale media, soos Twitter en Facebook, waar kwessies van kultuur en diversiteit gereeld ter sprake kom. Westerlinge kan baie negatiewe persepsies van Islam en Moslems vorm wanneer hulle oorval word met ’n stortvloed beelde van gruwelikhede wat uitgevoer word deur ekstremistegroepe soos die Islamitiese Staat van Irak en die Ooste (ISIS. Die gevolg is dat alle Moslems gestereotipeer word as fundamentaliste, terroriste en onderdrukkers van vroue. Hierdie kenniskonstruk word gemanipuleer deur die media. ’n Begrip van die redes waarom vroue ’n stuk lap – die kopdoek – dra, kan ’n beginpunt wees vir die verandering van persepsies van Moslems en hul verskillende praktyke. Opvoeders moet oppas om nie net verdraagsaamheid tussen verskillende kulturele groepe te verkondig nie, want verdraagsaamheid impliseer ’n blote bestuur van ’n mens se gevoelens van afsku vir dit wat verdra word. Vrae wat uit ’n standpunt van kritiese geletterdheid gestel kan word aan tekste soos The breadwinner-trilogie deur Deborah Ellis en The girl in the tangerine scarf by Mohja Kahf, word bespreek as voorbeelde wat in die klaskamer gebruik kan word. Hierdie tekste beeld Moslemvroue en -meisies baie anders uit en kan vergelykend gelees word

  11. Development of an Automated Airfield Dynamic Cone Penetrometer (AADCP) Prototype and the Evaluation of Unsurfaced Airfield Seismic Surveying Using Spectral Analysis of Surface Waves (SSW) Technology.

    Science.gov (United States)

    1993-12-01

    mnwwrowl «rlpl« Flar* Ijrp«. Longth 8.3 ft V« lgbt 1 lb. Signal Duration 7 soo. Figure 2.21 Aerial Penetrometer (Molineux 1955) 58 springs, for...Preliminary testing showed that the penetration rod which carried the weight of the piston apparatus did not move. The movement came from the air piston...inclined gripper teeth set inside a narrow barrel that allowed penetration in one direction but locked tight against the rod if movement occurred in

  12. Environmental Compliance Assessment System (ECAS) - Japan Settlement

    Science.gov (United States)

    1993-12-01

    substancies (se defiitidons) were released. Wa relas into die ( 1X2X3 ) cavirwiment of specific substances from a soo Verify tha the following actions were...perfonmed.: ( 1X2X3 ) and smouke emitting (ecu- ity, die izntallation has ee measure w res taken mtl Pwp h isiinspecific dud=e and may de- =!Maon took weares...Storage and Handling 2-12 through 2-14 ( 1X2X3 )(4)(5) Signs 2-15 (1)(2)(4) Worker Protection 2-16 and 2-17 (2X3) Releases 2-18 (1)(2) *CONTACT/LOCATION

  13. Presoja notranjih kontrol pri obračunu davka na dodano vrednost na primeru "Podjetja x"

    OpenAIRE

    Majcen, Borut

    2016-01-01

    Poslovanje podjetja si je ob odsotnosti notranjih kontrol nemogoče predstavljati. Podjetja so podvržena raznim tveganjem, še posebej v današnjih razmerah globalnega poslovanja, ko se podjetja soočajo z vedno novimi izzivi, kar prinaša tudi nova tveganja. Najučinkovitejši ukrep za obvladovanje tveganj predstavlja vzpostavitev sistema notranjih kontrol. Obvladovanje tveganj pa ne poteka samo na ravni podjetja kot celote, ampak je prisotno na vseh področjih delovanja podjetja, torej tudi na p...

  14. Drug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer

    OpenAIRE

    Park G; Bae SH; Park W; Han S; Park M; Shin S; Shin YG; Yim DS

    2017-01-01

    Gab-jin Park,1 Soo Hyeon Bae,1 Wan-Su Park,1 Seunghoon Han,1 Min-Ho Park,2 Seok-Ho Shin,2 Young G Shin,2 Dong-Seok Yim1,2 1Department of Clinical Pharmacology and Therapeutics, Seoul St Mary’s Hospital, PIPET (Pharmacometrics Institute for Practical Education and Training), College of Medicine, Catholic University of Korea, Seoul, South Korea; 2College of Pharmacy, Chungnam National University, Daejeon, South Korea Purpose: A microdose drug–drug interaction (DDI) study may be a ...

  15. MOBILNO POSLOVANJE NA PRIMERU UPORABE MICROSOFT DYNAMICS CRM

    OpenAIRE

    Duh, Tamara

    2016-01-01

    Hitro razvijajoči se svet nas spodbuja k hitremu reagiranju na novosti, ki se pojavljajo na trgu. Prav zaradi tega je danes zelo pomembno upravljati z mobilnimi napravami, da se lahko hitro in brez težav soočimo z morebitnimi težavami oz. zagatami. Prav iz tega razloga je mobilno poslovanje ena izmed inovativnih rešitev, ki ljudem omogoča seznanjenost z informacijami na vsakem koraku in omogoča hiter odziv na spremembe. Prav ta rešitev omogoča podjetjem, da so konkurenčna in hkrati lahko hitr...

  16. RAZVOJ IN INTEGRACIJA SISTEMA CRM ZA PODPORO REZERVACIJSKEGA SPLETNEGA PORTALA

    OpenAIRE

    Hojnik, Mitja

    2016-01-01

    V današnjem času, ko se trgi dramatično spreminjajo in se konkurenti v poslovnem svetu dnevno soočajo z velikimi izzivi, kot so globalizacija, rastoča konkurenca, zasičen trg in visoka pričakovanja ter želje strank, je izrazito pomembno, da podjetje nameni veliko pozornosti kakovostnim odnosom s strankami. Z dobrimi odnosi lahko podjetje računa na dolgoročno sodelovanje, zadovoljno in lojalno stranko in konec koncev tudi na finančno korist. Posledično si lahko s tem ustvari veliko konkuren...

  17. Die historiese betroubaarheid van die aartsvadervertellinge. 'n Beknopte bespreking van die huidige debat na aanleiding van die jongste publikasie

    Directory of Open Access Journals (Sweden)

    W. Vosloo

    1982-08-01

    Full Text Available Die afgelope twintig jaar was daar �n toenemende belangstelling in die aartsvadervertellinge in Genesis. Benewens die talle tydskrifartikels het skrywers soos die volgende ook boeke oor die onderwerp die lig laat sien: A. Parrot (1962, W. M. Clark (1964, R. Kilian (1966, R. E. Clements (1967, N. Lohfink (1967, H. Weidemann (1968, R. Martin-Achard (1969, T. L. Thompson (1974, J. van Seters (1975, J. P. Fokkelman (1975, C. Westermann (1976, R. Rendtorff (1977, J. Bright (1977, W. McKane (1979 en A. R. Millard en D. J. Wiseman (1980.

  18. Animations, games, and virtual reality for the Jing-Hang Grand Canal.

    Science.gov (United States)

    Chen, Wenzhi; Zhang, Mingmin; Pan, Zhigeng; Liu, Gengdai; Shen, Huaqing; Chen, Shengnan; Liu, Yong

    2010-01-01

    Digital heritage, an effective method to preserve and present natural and cultural heritage, is engaging many heritage preservation specialists and computer scientists. In particular, computer graphics researchers have become involved, and digital heritage has employed many CG techniques. For example, Daniel Pletinckx and his colleagues employed VR in a real museum at Ename, Belgium, and Zhigeng Pan and his colleagues applied it to construct a virtual Olympics museum. Soo-Chang Pei and his colleagues focused on restoring ancient Chinese paintings. Here, we describe how we've applied animations, computer games, and VR to China's famous Jing-Hang Grand Canal.

  19. Kaznivo dejanje prikazovanja, izdelave, posesti in posredovanja pornografskega gradiva (176. člen KZ-1)

    OpenAIRE

    Jeran, Ana

    2017-01-01

    Analiza 176. člena slovenskega kazenskega zakonika je pokazala, kako zapleteno je vprašanje prepovedi soočenja otrok s pornografskim gradivom in kako nujno potrebna je primerna inkriminacija otroške pornografije zaradi vse bolj razširjenega in dostopnega interneta. Gre za najhitreje rastoči internetni trg, zato je za boj proti tovrstnemu kriminalu potrebno sodelovanje na mednarodni ravni, ki se odraža v številnih mednarodnopravno sprejetih aktih, ki obravnavajo to materijo. Glavni cilj inkrim...

  20. VPLIV ULCEROZNEGA KOLITISA NA KAKOVOST ŽIVLJENJA

    OpenAIRE

    Dugi, Maja

    2015-01-01

    Pri vsaki bolezni je zelo pomembna kakovost življenja pacientov. Ulcerozni kolitis je kronična bolezen, ki je znana po obdobjih mirovanja in izbruhov, kar definitivno vpliva na posameznika, ki se s tem spopada. Sooča se z raznimi omejitvami, ki vplivajo na njegov vsakdan. Rezultati raziskave so pokazali, da je kakovost življenja bolnikov z ulceroznim kolitisom izrazito okrnjena. Ne le, da se spopadajo z bolečino, ampak tudi s psihičnimi in socialnimi posledicami, ki vplivajo na fizične aktivn...