Improving nuclear plant management effectiveness: Aligning strategy, systems, and people

International Nuclear Information System (INIS)

Price, K.F.

1991-01-01

The effectiveness of any organization requires alignment of the appropriate financial, physical, and human resources. The manager's role is to efficiently utilize the right combination of these resources to achieve organizational objectives. In-depth studies of the nuclear programs of three major investor-owned utilities using a culture assessment process called the communication, values, and rewards (CVR) assessment have shown significant misalignments in those organizations' strategies, systems and people management. The CVR assessment related employees' perceptions of what drives their company's culture with the stated company strategic direction and management philosophies. Specifically, CVR provides a comparison of employee-held work-related values with those desired by management. Data obtained by a CVR assessment can be used to understand organizational misalignment and make changes to bring systems into alignment with corporate strategy and culture

Organizational performance, Marketing strategy, and Financial strategic alignment: an empirical study on Iranian pharmaceutical firms.

Science.gov (United States)

Mohammadzadeh, Mehdi; Aarabi, Sied Mohammad; Salamzadeh, Jamshid

2013-08-02

Strategic Functional-level planning should be aligned with business level and other functional strategies of a company. It is presumed that assimilating the strategies could have positive contribution to business performance, in this regard alignment between marketing strategy and financial strategy seems to be the most important strategies being studied. An empirical work in generic pharmaceutical manufacturing companies for evaluating effect of alignment between these two functions on organizational performance was developed in this paper. All Iranian pharmaceutical generic manufactures listed in Tehran stock market have been tested for period of five years between 2006-2010 and their marketing strategies were determined by using Slater and Olson taxonomy and their financial strategies have been developed by calculating total risk and total return of sample companies for five years based on rate of risk and return in the frame of a 2 × 2 matrix. For the business performance three profitability indices including Q-Tubin (Rate of market value to net asset value), ROA (Return on Asset), ROE (Return on Equity) have been tested. For analysis, a series of one-way ANOVAs as a collection of statistical models within marketing strategies considering financial strategy as independent variable and the three performance measures as dependent variables was used. Results show strategic alignment between financial and marketing has significant impact on profitability of company resulting in arise of all three profitability indices. Q tubing's rate were 2.33,2.09,2.29,2.58 and rate of ROA were 0.21,0.194,0.25,0.22 and rate of ROE were 0.44,0.46,0.45,0.42 for matched strategy types, respectively the rates shown here are more than average meaning that specific type of marketing strategy is fitted with specific type of financial strategy. Managers should not consider decisions regarding marketing strategy independently of their financial strategy.

Aligning corporate real estate with the corporate strategies of higher education institutions

NARCIS (Netherlands)

Beckers, R; van der Voordt, Theo; Dewulf, G

2015-01-01

Purpose
The purpose of this paper is to explore how corporate real estate (CRE) managers of higher education institutions formulate their CRE strategies and CRE operating decisions to align CRE with the corporate strategies of these institutions.

Design/methodology/approach
An

Aligning corporate real estate with the corporate strategies of higher education institutions

NARCIS (Netherlands)

Theo van der Voordt; Geert Dewulf; Ronald Beckers

2015-01-01

Purpose – The purpose of this paper is to explore how corporate real estate (CRE) managers of higher education institutions formulate their CRE strategies and CRE operating decisions to align CRE with the corporate strategies of these institutions. Design/methodology/approach – An analytical

Managing the Right Projects: Best Practices to Align Project and Corporate Strategies

Science.gov (United States)

Watkins, Bobby

2012-01-01

If there's a human endeavor that exemplifies teamwork, it is space exploration. And that teamwork absolutely cannot happen effectively if the boots on the ground the people doing the work - don't understand how their work aligns with the larger goal. This presentation will discuss some best management practices from NASA's Marshall Space Flight Center that have succeeded in helping employees become informed, engaged and committed to the space agency's important missions. Specific topics include: Alignment Criteria: Linking Projects To Corporate Strategy. Resource Management: Best Practices For Resource Management. Strategic Analysis: Supporting Decision Making In A Changing Environment. Communication Strategies: Best Practices To Communicate Change. Benefits Achieved And Lessons Learned.

How to align the organization of the CREM-department to strategy during a recession

OpenAIRE

Thijs Ploumen; Rianne Appel Meulenbroek; Jos Smeets

2015-01-01

Purpose - In times of recession a lot of companies need to reduce costs. This also affects the budgets that are available for corporate real estate (CRE). Therefore it is important that the organization of the CRE management (CREM)-department is optimally aligned with CRE-strategy. This study provides a tool for evaluating the organization of the CREM-department when applying the CRE-strategy of cost reduction.Design/methodology/approach - The evaluation tool for alignment of the organization...

Probing strategy-project alignment: The case of the South African Social Security Agency

Directory of Open Access Journals (Sweden)

Gerrit Van Der Waldt

2016-12-01

Full Text Available Public institutions, such as the South African Social Security Agency (SASSA increasingly function in multi-project environments to translate strategies successfully into service-delivery initiatives. However, this ‘projectification’ often causes projects to be designed and executed haphazardly. This can lead to budget and schedule overruns, and the general wastage of an organisation’s resources. Project failures often occur where organisations do not ensure that specific projects are aligned with their core strategies. The purpose of this article is to combine the theories and principles of organisation, management, strategic management, and project management in an effort to pinpoint core determinants that can help establish the extent to which an organisation manages the alignment of its strategic projects. In the present study, the author applied the principles of interdisciplinarity, systems thinking, and organisational integration. The combined core determinants that were uncovered were then used in an empirical investigation of SASSA. The purpose of this investigation is to identify particular challenges the organisation faces in aligning their strategies and projects successfully. Thereafter, a number of recommendations follow to address these challenges.

Organizational performance, Marketing strategy, and Financial strategic alignment: an empirical study on Iranian pharmaceutical firms

Science.gov (United States)

2013-01-01

Background Strategic Functional-level planning should be aligned with business level and other functional strategies of a company. It is presumed that assimilating the strategies could have positive contribution to business performance, in this regard alignment between marketing strategy and financial strategy seems to be the most important strategies being studied. An empirical work in generic pharmaceutical manufacturing companies for evaluating effect of alignment between these two functions on organizational performance was developed in this paper. Methods All Iranian pharmaceutical generic manufactures listed in Tehran stock market have been tested for period of five years between 2006–2010 and their marketing strategies were determined by using Slater and Olson taxonomy and their financial strategies have been developed by calculating total risk and total return of sample companies for five years based on rate of risk and return in the frame of a 2 × 2 matrix. For the business performance three profitability indices including Q-Tubin (Rate of market value to net asset value), ROA (Return on Asset), ROE (Return on Equity) have been tested. For analysis, a series of one-way ANOVAs as a collection of statistical models within marketing strategies considering financial strategy as independent variable and the three performance measures as dependent variables was used. Results Results show strategic alignment between financial and marketing has significant impact on profitability of company resulting in arise of all three profitability indices. Q tubing’s rate were 2.33,2.09,2.29,2.58 and rate of ROA were 0.21,0.194,0.25,0.22 and rate of ROE were 0.44,0.46,0.45,0.42 for matched strategy types, respectively the rates shown here are more than average meaning that specific type of marketing strategy is fitted with specific type of financial strategy. Conclusion Managers should not consider decisions regarding marketing strategy independently of their financial

Organizational Performance, Marketing Strategy, and Financial Strategic Alignment: an Empirical Study on Iranian Pharmaceutical Firms

Directory of Open Access Journals (Sweden)

Mehdi Mohammadzadeh

2013-08-01

Full Text Available Background:Strategic Functional-level planning should be aligned with business level and other functional strategies of a company. It is presumed that assimilating the strategies could have positive contribution to business performance, in this regard alignment between marketing strategy and financial strategy seems to be the most important strategies being studied. An empirical work in generic pharmaceutical manufacturing companies for evaluating effect of alignment between these two functions on organizational performance was developed in this paper.Methods:All Iranian pharmaceutical generic manufactures listed in Tehran stock market have been tested for period of five years between 2006--2010 and their marketing strategies were determined by using Slater and Olson taxonomy and their financial strategies have been developed by calculating total risk and total return of sample companies for five years based on rate of risk and return in the frame of a 2 x 2 matrix. For the business performance three profitability indices including Q-Tubin (Rate of market value to net asset value, ROA (Return on Asset, ROE (Return on Equity have been tested. For analysis, a series of one-way ANOVAs as a collection of statistical models within marketing strategies considering financial strategy as independent variable and the three performance measures as dependent variables was used.Results:Results show strategic alignment between financial and marketing has significant impact on profitability of company resulting in arise of all three profitability indices. Q tubing's rate were 2.33,2.09,2.29,2.58 and rate of ROA were 0.21,0.194,0.25,0.22 and rate of ROE were 0.44,0.46,0.45,0.42 for matched strategy types, respectively the rates shown here are more than average meaning that specific type of marketing strategy is fitted with specific type of financial strategy.Conclusion:Managers should not consider decisions regarding marketing strategy independently of their

Educational Leaders' Doctoral Research That Informed Strategies to Steer Their Organizations towards Cultural Alignment

Science.gov (United States)

Taysum, Alison

2016-01-01

This research generates new knowledge about how 24 educational leaders in the USA and England used their doctoral research to build narrative capital to inform strategies to steer their organizations towards cultural alignment. Cultural alignment prevents forms of segregation rooted in nation-states' wider historiography of education segregation…

Management strategies for aligning higher education accomodation with the user needs

NARCIS (Netherlands)

Theo van der Voordt; Ronald Beckers; Geert Dewulf

2015-01-01

Purpose This paper aims to explore the management strategies of facility managers and corporate real estate managers to align corporate real estate (CRE) with the needs of their organization and the end users in a changing context. Design/methodology/approach The paper first outlines the

Strategy and validation of fiducialisation for the pre-alignment of CLIC components

CERN Document Server

Griffet, S; Kemppinen, J; Mainaud Durand, H; Rude, V; Sterbini, G

2012-01-01

The feasibility of the high energy e+ e- linear collider CLIC (Compact Linear Collider) is very dependent on the ability to accurately pre-align its components. There are two 20 km long Main Linacs which meet in an interaction point (IP). The Main Linacs are composed of thousands of 2 m long modules. One of the challenges is to meet very tight alignment tolerances at the level of CLIC module: for example, the magnetic centre of a Drive Beam Quad needs to be aligned within 20 µm rms with respect to a straight line. Such accuracies cannot be achieved using usual measurement devices. Thus it is necessary to work in close collaboration with the metrology lab. To test and improve many critical points, including alignment, a CLIC mock-up is being assembled at CERN. This paper describes the application of the strategy of fiducialisation for the pre-alignment of CLIC mock-up components. It also deals with the first results obtained by performing measurements using a CMM (Coordinate Measuring Machine) to ensure the f...

An overview of steps and tools for the corporate real estate strategy alignment process

NARCIS (Netherlands)

Appel - Meulenbroek, H.A.J.A.; Haynes, B.

2014-01-01

Strategic thinking is a continuous process, alternating between thinking, planning and evaluating. Corporate real estate management (CREM) practitioners need to align their strategy and activities with corporate strategy during the entire process that the organisation goes through. Along the way,

Management strategies for aligning higher education accommodation with the user needs

NARCIS (Netherlands)

Beckers, R; van der Voordt, Theo; Dewulf, G

2015-01-01

Purpose – This paper aims to explore the management strategies of facility managers and corporate real estate managers to align corporate real estate (CRE) with the needs of their organization and the end users in a changing context. Design/methodology/approach – The paper first outlines the

The alignment of organisation strategy and risk appetite in the financial services industry

OpenAIRE

2014-01-01

M.Com. (Business Management) This study concerns itself with the concepts of strategy, risk management and risk appetite. Strategy and risk management playa very important role in any business, but it is very difficult to determine the interrelationship between strategy and risk. There is no scientific/academic proof and there is no model or framework on what the alignment between an organisation's strategy and risk appetite is. Therefore, the purpose of this study is to develop a risk app...

Coordination of Project and Current Activities on the Basis of the Strategy Alignment Metamodel in the Oil and Gas Company

Directory of Open Access Journals (Sweden)

R. Yu. Dashkov

2017-01-01

Full Text Available Purpose: the purpose of this article is to describe the Strategy Alignment Metamodel of the project and current activities, which allows us to connect the Goals and Strategies for Phases of the project with the Goals and Strategies of the company at all levels of the organization through targeted measurement and application of Interpretive Models. Building Networks of Goals and Strategies, and adopting organizational solutions, you coordinate the interaction of the Project office and departments of the company. This methodology is based on a Logical Rationale of the Contexts and Assumptions for establishing Goals and Strategies both for the project and for the company, and on preparation of Contexts and Assumptions, Goals and Strategies Alignment Matrices, which provides a flexible adaptation to the internal and external environment in the process of selecting the most successful Strategies to achieve the Goals. Methods: this article is based on the concept of Goals-Questions-Metrics+ Strategies, which is adapted as another concept of strategic monitoring and control system of projects: Goals-Phases-Metrics+Strategies. These concepts have formed the basis of the Strategy Alignment Metamodel, where a technology of Phases Earned Value Management is used as a measurement system for the project activity, and Balanced scorecard is applied for current operations. Results: strategy Alignment Metamodel of the project and current activities of the company is proposed hereby. It uses modern strategic monitoring and control systems for projects: Goals-Phases-Metrics+Strategies, and for the company: Goals-Questions-Metrics+ Strategies. The interaction between these systems is based on Contexts and Assumptions, Goals and Strategies Alignment Matrices. The existence of such matrices greatly simplifies management decisions and prevents the risk of delays in the execution of project Phases based on rational participation and coordination of the company�

Revisiting the Relationship of CSR and Corporate Philanthropy by Using Alignment Theory

OpenAIRE

von Schnurbein, Georg; Stühlinger, Sara

2015-01-01

Both, CSR and corporate philanthropy are expressions of the interferences between the company and its societal environment. However, the question of the relationship between CSR and corporate philanthropy remains unclear. We apply alignment theory to shed light on the interdependencies of CSR and corporate philanthropy. The relationship may be based on alignment, misalignment, or non-alignment. Our research is based on an empiric analysis of the sustainability rating of U.S. companies and it...

Exploratory Study on Alignment Between IT and Business Strategies

Directory of Open Access Journals (Sweden)

Wahyuni Reksoatmodjo

2012-05-01

Full Text Available Interaction and linkages between business and information technology (IT strategies remain a primary concern among executives. This study aims to gain an in depth understanding of how companies achieve alignment and the policy framework that underlies the efforts, particularly those that are associated with the most dominant factor that contributes to the establishment of strategic alignment, namely IT infrastructure flexibility. For that purpose, the study explored four companies engaged in the field of oil, electricity, and communication by adopting interpretive case study. Data were gathered using triangulation methods via field interviews, artifacts, document analysis, as well as direct observation. The textual data were elaborated by an intentional analysis in order to guide the study in exploring the phenomenon. The study identified elements that reflect IT infrastructure flexibilities namely connectivity, compatibility, modularity, IT staff knowledge and skills, and integration. Those elements cover both technical and behavioral dimensions of a company’s components that need to be included in the consideration during the planning phase

Aligning the unalignable: bacteriophage whole genome alignments.

Science.gov (United States)

Bérard, Sèverine; Chateau, Annie; Pompidor, Nicolas; Guertin, Paul; Bergeron, Anne; Swenson, Krister M

2016-01-13

In recent years, many studies focused on the description and comparison of large sets of related bacteriophage genomes. Due to the peculiar mosaic structure of these genomes, few informative approaches for comparing whole genomes exist: dot plots diagrams give a mostly qualitative assessment of the similarity/dissimilarity between two or more genomes, and clustering techniques are used to classify genomes. Multiple alignments are conspicuously absent from this scene. Indeed, whole genome aligners interpret lack of similarity between sequences as an indication of rearrangements, insertions, or losses. This behavior makes them ill-prepared to align bacteriophage genomes, where even closely related strains can accomplish the same biological function with highly dissimilar sequences. In this paper, we propose a multiple alignment strategy that exploits functional collinearity shared by related strains of bacteriophages, and uses partial orders to capture mosaicism of sets of genomes. As classical alignments do, the computed alignments can be used to predict that genes have the same biological function, even in the absence of detectable similarity. The Alpha aligner implements these ideas in visual interactive displays, and is used to compute several examples of alignments of Staphylococcus aureus and Mycobacterium bacteriophages, involving up to 29 genomes. Using these datasets, we prove that Alpha alignments are at least as good as those computed by standard aligners. Comparison with the progressive Mauve aligner - which implements a partial order strategy, but whose alignments are linearized - shows a greatly improved interactive graphic display, while avoiding misalignments. Multiple alignments of whole bacteriophage genomes work, and will become an important conceptual and visual tool in comparative genomics of sets of related strains. A python implementation of Alpha, along with installation instructions for Ubuntu and OSX, is available on bitbucket (https://bitbucket.org/thekswenson/alpha).

Alignment methods: strategies, challenges, benchmarking, and comparative overview.

Science.gov (United States)

Löytynoja, Ari

2012-01-01

Comparative evolutionary analyses of molecular sequences are solely based on the identities and differences detected between homologous characters. Errors in this homology statement, that is errors in the alignment of the sequences, are likely to lead to errors in the downstream analyses. Sequence alignment and phylogenetic inference are tightly connected and many popular alignment programs use the phylogeny to divide the alignment problem into smaller tasks. They then neglect the phylogenetic tree, however, and produce alignments that are not evolutionarily meaningful. The use of phylogeny-aware methods reduces the error but the resulting alignments, with evolutionarily correct representation of homology, can challenge the existing practices and methods for viewing and visualising the sequences. The inter-dependency of alignment and phylogeny can be resolved by joint estimation of the two; methods based on statistical models allow for inferring the alignment parameters from the data and correctly take into account the uncertainty of the solution but remain computationally challenging. Widely used alignment methods are based on heuristic algorithms and unlikely to find globally optimal solutions. The whole concept of one correct alignment for the sequences is questionable, however, as there typically exist vast numbers of alternative, roughly equally good alignments that should also be considered. This uncertainty is hidden by many popular alignment programs and is rarely correctly taken into account in the downstream analyses. The quest for finding and improving the alignment solution is complicated by the lack of suitable measures of alignment goodness. The difficulty of comparing alternative solutions also affects benchmarks of alignment methods and the results strongly depend on the measure used. As the effects of alignment error cannot be predicted, comparing the alignments' performance in downstream analyses is recommended.

Measuring the Maturity of IT and Business Strategies Alignment in Organization: Case Study of SAIPA-Yadak Company

Directory of Open Access Journals (Sweden)

Mohmmad Reza Taghva

2010-04-01

Full Text Available IT strategic planning towards realizing organizational is one of the most important topics among managers of leading companies. It is known as alignment of IT and business strategies. The alignment factors identified in Luftman model on IT-Business Alignment form the basis of the present study. Luftman model is comprised of five levels, each level consisting of six factors. A questionnaire was designed and distributed among managemers in Saipa Yadak in order to identify the impact of each alignment factor. Thereafter in order to measure the extent of IT-Business alignment, another questionnaire was devised to determine company’s current status. Finally a balanced alignment factor was calculated. Results indicate that Saipa Yadak is at the third alignment level according to Luftman model. This illustrates a stage of total focus. Tactics are offered for approaching the fourth level of alignment.

Societal response to nanotechnology: converging technologies–converging societal response research?

International Nuclear Information System (INIS)

Ronteltap, Amber; Fischer, Arnout R. H.; Tobi, Hilde

2011-01-01

Nanotechnology is an emerging technology particularly vulnerable to societal unrest, which may hinder its further development. With the increasing convergence of several technological domains in the field of nanotechnology, so too could convergence of social science methods help to anticipate societal response. This paper systematically reviews the current state of convergence in societal response research by first sketching the predominant approaches to previous new technologies, followed by an analysis of current research into societal response to nanotechnology. A set of 107 papers on previous new technologies shows that rational actor models have played an important role in the study of societal response to technology, in particular in the field of information technology and the geographic region of Asia. Biotechnology and nuclear power have, in contrast, more often been investigated through risk perception and other affective determinants, particularly in Europe and the USA. A set of 42 papers on societal response to nanotechnology shows similarities to research in biotechnology, as it also builds on affective variables such as risk perception. Although there is a tendency to extend the rational models with affective variables, convergence in social science approaches to response to new technologies still has a long way to go. The challenge for researchers of societal response to technologies is to converge to some shared principles by taking up the best parts from the rational actor models dominant in information technology, whilst integrating non-rational constructs from biotechnology research. The introduction of nanotechnology gives a unique opportunity to do so.

Bridging the Gap: Development of the Entrepreneurial Philanthropy Alignment Model

NARCIS (Netherlands)

Rath, Jos; Schuyt, T.N.M.

2017-01-01

Partnerships are increasingly considered to have the potential to address societal problems that one single actor cannot solve. This paper rationalises the development of partnerships between entrepreneurs and non-profit organisations by the effects of its alignment. In organisations, the process of

Evaluating the Societal Impact of Using Drones to Support Urban Upgrading Projects

Directory of Open Access Journals (Sweden)

Caroline M. Gevaert

2018-03-01

Full Text Available Unmanned Aerial Vehicles (UAVs, or drones, have been gaining enormous popularity for many applications including informal settlement upgrading. Although UAVs can be used to efficiently collect highly detailed geospatial information, there are concerns regarding the ethical implications of its usage and the potential misuse of data. The aim of this study is therefore to evaluate the societal impacts of using UAVs for informal settlement mapping through two case studies in Eastern Africa. We discuss how the geospatial information they provide is beneficial from a technical perspective and analyze how the use of UAVs can be aligned with the values of: participation, empowerment, accountability, transparency, and equity. The local concept of privacy is investigated by asking citizens of the informal settlements to identify objects appearing in UAV images which they consider to be sensitive or private. As such, our research is an explicit example of how to increase citizen participation in the discussion of geospatial data security and privacy issues over urban areas and provides a framework of strategies illustrating how such issues can be addressed.

Alignment of Supply Chain Strategy with Marketing and Sales activities in Bosnian Small and Medium Enterprises

OpenAIRE

Muhammed Kürşad Özlen; Azra Muratovic; Nedzma Begic

2013-01-01

The objective of this research is to identify the alignment of supply chain strategies with marketing and financial activities in Bosnian small and medium enterprises. Regarding the methodology used, we have conducted a survey and collected the data in an excel spreadsheet and then analyzed descriptively. The research achieved poor marketing strategies and no customer centric view in these marketing strategies, furthermore, not efficient and effective supply chain management strategy and comp...

Reflecting Societal Values in Designing Flood Risk Management Strategies

Directory of Open Access Journals (Sweden)

Adamson Mark

2016-01-01

Full Text Available In 2006, the Office of Public Works (OPW began the National Catchment-based Flood Risk Assessment and Management (CFRAM Programme through a series of pilot studies. A Multi-Criteria Analysis (MCA Framework was developed through the pilot studies that integrated a number of objectives related to a wide range of potential impacts and benefits into the core of process of appraising and selecting suitable flood risk management measures for a given area or location, and then for prioritising national investments for different schemes and projects. This MCA Framework, that provides a systematic process of developing a non-monetised but numerical indicator of benefit and impact, has since been implemented nationally in the preparation of the Flood Risk Management Plans (FRMPs. A key feature of the MCA is that it should represent societal values. To this end, nationally representative quantitative research was undertaken to determine global weights that reflect the perceived importance of each of the objectives for reducing economic, social and environmental / cultural risks in flood management strategies. Saaty’s Analytical Hierarchy Process (AHP, in conjunction with a pair-wise comparison of criteria relating to these risks, was utilised to determine weights. In excess of 1,000 structured interviews were completed where the relative importance of these objectives were assessed using a seven-point scale. The weighting given to each of the 13 specific objectives identified broadly followed expectations, with risk to people followed by risk to homes and properties being respectively the first and second most important, although some were given greater or less weighting than expected. The national application of the MCA Framework, using the weighted objectives based on this process, through the CFRAM Programme has generally lead to the identification of appropriate and, based on local consultation, acceptable options for each community.

Aligning business strategy of incubator center and tenants

Science.gov (United States)

Prasetyawan, Yudha; Agustiani, Elly; Jumayla, Sari

2017-06-01

Incubator center is developed to help a particular group of small business players to achieve the expected business growth. In this center, business players often called as tenants will get assistances in pertaining with space, professional network, marketing, investment or funding, and training to improve their business capability. There are three types of incubator center, namely universities that help their alumni or business people in their surrounded area, company that supports small business as the corporate social responsibility, and independent organizations that have specialties in the business development. Some might success in increasing the capacity of the tenants, while other can have difficulties to increase the simplest business capability, e.g., to define the production cost to measure the profit. This study was intended to propose a model to align the business strategy between incubator center and its tenants. The sales and profit growth are the main priorities for the tenants together with their business capability and sustainability. The proposed alignment model provides measurement tools that link the motivation of tenants for joining the incubation process with the mission of incubator center. The linkage covered the key performance indicators (KPI), steps to achieve the target and evaluation tools to improve the current handicaps. An experiment on 4 (four) diverse business fields of the tenants of an incubator center was performed to test the model. As a result, the increase of KPI of incubator center will simultaneously yield a higher value of the tenants' sales.

Chinese business students’ changes in beliefs and strategy use in a constructively aligned PBL course

DEFF Research Database (Denmark)

Zhao, Ke; Zhang, Jie; Du, Xiangyun

2017-01-01

This study adopted a longitudinal retrospective case study approach to investigate Chinese business students’ transitional learning experience in a problem-based learning (PBL) course with innovative assessment practices. The study focused on students’ beliefs and strategy use in a constructively...... that align social constructivist learning principles with students’ beliefs and strategies. The results also highlight the importance of developing appropriate assessment rubrics to enhance student engagement with PBL learning for improved outcomes....

Business-IT alignment and service oriented architecture: a proposal of a service-oriented strategic alignment model

NARCIS (Netherlands)

Cuenca, L.; Boza, A.; Ortiz, A.; Trienekens, J.J.M.; Hammoudi, S.; Cordeiro, J.; Maciaszek, L

2014-01-01

Since its inception, SOA has been postulated as the solution to the problems of alignment between business and IT. However, these problems still remain, especially at external level where the business strategy should be aligned with the IT strategy. Based on the Henderson and Venkatraman’s strategic

A practical strategy for the accurate measurement of residual dipolar couplings in strongly aligned small molecules

Science.gov (United States)

Liu, Yizhou; Cohen, Ryan D.; Martin, Gary E.; Williamson, R. Thomas

2018-06-01

Accurate measurement of residual dipolar couplings (RDCs) requires an appropriate degree of alignment in order to optimize data quality. An overly weak alignment yields very small anisotropic data that are susceptible to measurement errors, whereas an overly strong alignment introduces extensive anisotropic effects that severely degrade spectral quality. The ideal alignment amplitude also depends on the specific pulse sequence used for the coupling measurement. In this work, we introduce a practical strategy for the accurate measurement of one-bond 13C-1H RDCs up to a range of ca. -300 to +300 Hz, corresponding to an alignment that is an order of magnitude stronger than typically employed for small molecule structural elucidation. This strong alignment was generated in the mesophase of the commercially available poly-γ-(benzyl-L-glutamate) polymer. The total coupling was measured by the simple and well-studied heteronuclear two-dimensional J-resolved experiment, which performs well in the presence of strong anisotropic effects. In order to unequivocally determine the sign of the total coupling and resolve ambiguities in assigning total couplings in the CH2 group, coupling measurements were conducted at an isotropic condition plus two anisotropic conditions of different alignment amplitudes. Most RDCs could be readily extracted from these measurements whereas more complicated spectral effects resulting from strong homonuclear coupling could be interpreted either theoretically or by simulation. Importantly, measurement of these very large RDCs actually offers significantly improved data quality and utility for the structure determination of small organic molecules.

Productive interactions for societal impact: Developing a research information system for agriculture (RIS-Agric) at Stellenbosch University, South Africa

Energy Technology Data Exchange (ETDEWEB)

Boshoff, N.; Esterhuyse, H.

2016-07-01

Assessments of the societal impact of research rely on primary data as input to the relevant indicators. In the current project, the data collection for indicator construction is guided by the SIAMPI approach to societal impact assessment. According to SIAMPI, the achievement of societal impact involves two elements: stakeholders and productive interactions. The latter includes three kinds of interactions: direct personal interactions; indirect interactions where contact is mediated by a material or human ‘carrier’; and financial interactions that refer to the economic exchanges between researchers and stakeholders. The question to be explored is whether the assessment of the societal impact of research can be facilitated by capturing any direct, indirect and financial interactions between researchers and societal stakeholders in a research information system. CREST/SciSTIP is developing such a system, called RIS-Agric, in cooperation with the Faculty of AgriSciences at Stellenbosch University and four agricultural research funders in South Africa that represent different agricultural commodities. A RIS with productive interactions at its core – and the funded research project as the unit of observation – will produce the necessary data for indicators linked to the societal impact of research, in addition to generating insights about the ‘pathway’ from research to societal impact. The indicators need to be ‘socially robust’ in the sense that their validation processes should include the research beneficiaries and their representatives. In doing so, RIS-Agric will produce a useful, standardised measurement mechanism that is aligned across the different commodities. The focus on productive interactions will be supplemented by other methods in order to enable the quantification of societal impact in the form of ‘impact scores’. (Author)

Biodiesel and Integrated STEM: Vertical Alignment of High School Biology/Biochemistry and Chemistry

Science.gov (United States)

Burrows, Andrea C.; Breiner, Jonathan M.; Keiner, Jennifer; Behm, Chris

2014-01-01

This article explores the vertical alignment of two high school classes, biology and chemistry, around the core concept of biodiesel fuel production. High school teachers and university faculty members investigated biodiesel as it relates to societal impact through a National Science Foundation Research Experience for Teachers. Using an action…

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G. Gomez

Since December, the muon alignment community has focused on analyzing the data recorded so far in order to produce new DT and CSC Alignment Records for the second reprocessing of CRAFT data. Two independent algorithms were developed which align the DT chambers using global tracks, thus providing, for the first time, a relative alignment of the barrel with respect to the tracker. These results are an important ingredient for the second CRAFT reprocessing and allow, for example, a more detailed study of any possible mis-modelling of the magnetic field in the muon spectrometer. Both algorithms are constructed in such a way that the resulting alignment constants are not affected, to first order, by any such mis-modelling. The CSC chambers have not yet been included in this global track-based alignment due to a lack of statistics, since only a few cosmics go through the tracker and the CSCs. A strategy exists to align the CSCs using the barrel as a reference until collision tracks become available. Aligning the ...

Regarding Societal Change

Directory of Open Access Journals (Sweden)

Leda Blackwood

2013-12-01

Full Text Available In this paper we introduce our special thematic section on societal change. We begin by providing an overview of the aims of the section, and how these aims grew out of a need to address conceptual and empirical challenges in the study of societal change. In response to these challenges, the section was intended to provide a forum for theoretical and empirical work from a range of disciplinary perspectives on how societies change, and how such change can be understood. Together, the contributions argue for (1 the need to contextualize the study of societal change, (2 the value of considering factors and processes other than collective action in transforming societies, (3 the importance of ideology and its operation through social institutions such as news media, and (4 an imperative to ensure that our research is fully engaged with society in terms of its grounding in social issues, its sensitivity to our own social context as researchers, and in its practices and outcomes.

The Relevance of IT Service Management Maturity for IT Alignment and Its Strategy and Organization Size Contingencies

DEFF Research Database (Denmark)

Winkler, Till J.; Wulf, Jochen; Brenner, Walter

2014-01-01

to address whether and in which contingent contexts the institutionalization of ITSM frameworks, understood as collections of IT governance mechanisms, may contribute to IT alignment, a widely recognized prerequisite for superior IT performance. This workshop contribution is based on a cross-sectional survey...... with ITSM experts in which we measure levels of maturity of different ITSM planning and execution processes and focus on the organizations’ IS strategy (innovative versus conservative) as well as organization size as contingency factors hypothesized to moderate the effect of ITSM maturity on IT alignment....... Our findings strengthen the view that ITSM frameworks like ITIL incorporate governance mechanisms that can enhance the effect of the established relational antecedents of IT alignment. In addition, our data particularly provide evidence for the relevance of execution-level ITSM processes and suggest...

Articulation: how societal goals matter in nanotechnology

NARCIS (Netherlands)

Bos, C.|info:eu-repo/dai/nl/338018387

2016-01-01

Science policies try to steer scientists to conduct societally relevant research. This societal relevance is often expressed in large societal goals, such as addressing sustainability or helping with the problems that an ageing society might bring. Emerging technologies, like nanotechnology, are

Comparison of societal risks

International Nuclear Information System (INIS)

Bennett, C.A.

1976-01-01

The utility of the societal risk approach to the design and evaluation of safeguards systems is examined with particular reference to the comparison of the relative effectiveness of various safeguards mechanisms. Research on threat evaluation is reviewed, and the need for further research on consequences is discussed in terms of the extension of the definition of the safeguards objective from system capability to societal consequences and the establishment of public confidence. 14 references

Post-communist democracy vs. totalitarianism: Contrasting patterns of need satisfaction and societal frustration.

Czech Academy of Sciences Publication Activity Database

Klicperová-Baker, Martina; Košťál, Jaroslav

2017-01-01

Roč. 50, č. 2 (2017), s. 99-111 ISSN 0967-067X R&D Projects: GA ČR GA15-11062S Grant - others:AV ČR(CZ) StrategieAV21/14 Program:StrategieAV Institutional support: RVO:68081740 Keywords : Totalitarianism * Post- communism * Frustration * Societal frustration * Democracy * Memory * Maslow * Hierarchy of needs Subject RIV: AN - Psychology OBOR OECD: Psychology (including human - machine relations) Impact factor: 0.607, year: 2016

Post-communist democracy vs. totalitarianism: Contrasting patterns of need satisfaction and societal frustration.

Czech Academy of Sciences Publication Activity Database

Klicperová-Baker, Martina; Košťál, Jaroslav

2017-01-01

Roč. 50, č. 2 (2017), s. 99-111 ISSN 0967-067X R&D Projects: GA ČR GA15-11062S Grant - others:AV ČR(CZ) StrategieAV21/14 Program:StrategieAV Institutional support: RVO:68081740 Keywords : Totalitarianism * Post-communism * Frustration * Societal frustration * Democracy * Memory * Maslow * Hierarchy of needs Subject RIV: AN - Psychology OBOR OECD: Psychology (including human - machine relations) Impact factor: 0.607, year: 2016

Cultural diversity, economic development and societal instability

Science.gov (United States)

Nettle, D.; Grace, J.B.; Choisy, M.; Cornell, H.V.; Guegan, J.-F.; Hochberg, M.E.

2007-01-01

Background. Social scientists have suggested that cultural diversity in a nation leads to societal instability. However, societal instability may be affected not only by within-nation on ?? diversity, but also diversity between a nation and its neighbours or ?? diversity. It is also necessary to distinguish different domains of diversity, namely linguistic, ethnic and religious, and to distinguish between the direct effects of diversity on societal instability, and effects that are mediated by economic conditions. Methodology/Principal Findings. We assembled a large cross-national dataset with information on ?? and ?? cultural diversity, economic conditions, and indices of societal instability. Structural equation modeling was used to evaluate the direct and indirect effects of cultural diversity on economics and societal stability. Results show that different type and domains of diversity have interacting effects. As previously documented, linguistic ?? diversity has a negative effect on economic performance, and we show that it is largely through this economic mechanism that it affects societal instability. For ?? diversity, the higher the linguistic diversity among nations in a region, the less stable the nation. But, religious ?? diversity has the opposite effect, reducing instability, particularly in the presence of high linguistic diversity. Conclusions. Within-nation linguistic diversity is associated with reduced economic performance, which, in turn, increases societal instability. Nations which differ linguistically from their neighbors are also less stable. However, religious diversity between, neighboring nations has the opposite effect, decreasing societal instability.

Cultural diversity, economic development and societal instability.

Science.gov (United States)

Nettle, Daniel; Grace, James B; Choisy, Marc; Cornell, Howard V; Guégan, Jean-François; Hochberg, Michael E

2007-09-26

Social scientists have suggested that cultural diversity in a nation leads to societal instability. However, societal instability may be affected not only by within-nation or alpha diversity, but also diversity between a nation and its neighbours or beta diversity. It is also necessary to distinguish different domains of diversity, namely linguistic, ethnic and religious, and to distinguish between the direct effects of diversity on societal instability, and effects that are mediated by economic conditions. We assembled a large cross-national dataset with information on alpha and beta cultural diversity, economic conditions, and indices of societal instability. Structural equation modeling was used to evaluate the direct and indirect effects of cultural diversity on economics and societal stability. Results show that different types and domains of diversity have interacting effects. As previously documented, linguistic alpha diversity has a negative effect on economic performance, and we show that it is largely through this economic mechanism that it affects societal instability. For beta diversity, the higher the linguistic diversity among nations in a region, the less stable the nation. But, religious beta diversity has the opposite effect, reducing instability, particularly in the presence of high linguistic diversity. Within-nation linguistic diversity is associated with reduced economic performance, which, in turn, increases societal instability. Nations which differ linguistically from their neighbors are also less stable. However, religious diversity between neighboring nations has the opposite effect, decreasing societal instability.

Societal embedding of climate-friendly innovations

International Nuclear Information System (INIS)

Vaeyrynen, E.; Kivisaari, Sirkku; Lovio, R.

2002-01-01

This project assesses the possibilities of constructing a market for climate-friendly energy technologies by applying the process of 'societal embedding of innovations'. The term refers to an interactive learning process amongst three groups of key actors: producers, users and societal actors. Their co-operation shapes the innovation to fit the needs of the market and contributes to creation of conditions in which the innovation can be adopted. The project consists of two case studies: (1) Shaping of the ESCO energy service concept in Finnish municipalities and (2) Increasing the use of wood pellets in single-family houses. The case studies have illustrated the possibilities and limitations concerning the application of societal embedding in the energy sector. The project indicates that societal embedding may promote the implementation of climate-friendly energy technologies in at least three ways. Firstly, the process mobilises key actors to cooperation. This generates interactive learning on the problem and its solving. Market construction is forged ahead by mutual adaptation of the innovation and its environment. Secondly, this approach offers a tool to examine the societal quality of the innovation, a question related vitally to climate change. Thirdly, by producing new knowledge of the needs on the market this approach supports the societal actors in choosing different instruments to induce the intended transition to sustainability. (orig.)

Ethical, legal and societal considerations on Zika virus epidemics complications in scaling-up prevention and control strategies.

Science.gov (United States)

Tambo, Ernest; Madjou, Ghislaine; Khayeka-Wandabwa, Christopher; Olalubi, Oluwasogo A; Chengho, Chryseis F; Khater, Emad I M

2017-08-25

Much of the fear and uncertainty around Zika epidemics stem from potential association between Zika virus (ZIKV) complications on infected pregnant women and risk of their babies being born with microcephaly and other neurological abnormalities. However, much remains unknown about its mode of transmission, diagnosis and long-term pathogenesis. Worries of these unknowns necessitate the need for effective and efficient psychosocial programs and medical-legal strategies to alleviate and mitigate ZIKV related burdens. In this light, local and global efforts in maintaining fundamental health principles of moral, medical and legal decision-making policies, and interventions to preserve and promote individual and collectiveHuman Rights, autonomy, protection of the most vulnerable, equity, dignity, integrity and beneficence that should not be confused and relegated by compassionate humanitarian assistance and support. This paper explores the potential medical and ethical-legal implications of ZIKV epidemics emergency response packages and strategies alongside optimizing reproductive and mental health policies, programs and best practice measures. Further long-term cross-borders operational research is required in elucidating Zika-related population-based epidemiology, ethical-medical and societal implications in guiding evidence-based local and global ZIKV maternal-child health complications related approaches and interventions. Core programs and interventions including future Zika safe and effective vaccines for global Zika immunization program in most vulnerable and affected countries and worldwide should be prioritized.

Broader Societal Issues of Nanotechnology

International Nuclear Information System (INIS)

Roco, M.C.

2003-01-01

Nanoscale science and engineering are providing unprecedented understanding and control over the basic building blocks of matter, leading to increased coherence in knowledge, technology, and education. The main reason for developing nanotechnology is to advance broad societal goals such as improved comprehension of nature, increased productivity, better healthcare, and extending the limits of sustainable development and of human potential. This paper outlines societal implication activities in nanotechnology R and D programs. The US National Nanotechnology Initiative annual investment in research with educational and societal implications is estimated at about $30 million (of which National Science Foundation (NSF) awards about $23 million including contributions to student fellowships), and in nanoscale research with relevance to environment at about $50 million (of which NSF awards about $30 million and EPA about $6 million). An appeal is made to researchers and funding organizations worldwide to take timely and responsible advantage of the new technology for economic and sustainable development, to initiate societal implications studies from the beginning of the nanotechnology programs, and to communicate effectively the goals and potential risks with research users and the public

Broader Societal Issues of Nanotechnology

Science.gov (United States)

Roco, M. C.

2003-08-01

Nanoscale science and engineering are providing unprecedented understanding and control over the basic building blocks of matter, leading to increased coherence in knowledge, technology, and education. The main reason for developing nanotechnology is to advance broad societal goals such as improved comprehension of nature, increased productivity, better healthcare, and extending the limits of sustainable development and of human potential. This paper outlines societal implication activities in nanotechnology R&D programs. The US National Nanotechnology Initiative annual investment in research with educational and societal implications is estimated at about 30 million (of which National Science Foundation (NSF) awards about 23 million including contributions to student fellowships), and in nanoscale research with relevance to environment at about 50 million (of which NSF awards about 30 million and EPA about 6 million). An appeal is made to researchers and funding organizations worldwide to take timely and responsible advantage of the new technology for economic and sustainable development, to initiate societal implications studies from the beginning of the nanotechnology programs, and to communicate effectively the goals and potential risks with research users and the public.

Broader Societal Issues of Nanotechnology

Energy Technology Data Exchange (ETDEWEB)

Roco, M.C. [National Science Foundation (NSF) (United States)], E-mail: mroco@nsf.gov

2003-08-15

Nanoscale science and engineering are providing unprecedented understanding and control over the basic building blocks of matter, leading to increased coherence in knowledge, technology, and education. The main reason for developing nanotechnology is to advance broad societal goals such as improved comprehension of nature, increased productivity, better healthcare, and extending the limits of sustainable development and of human potential. This paper outlines societal implication activities in nanotechnology R and D programs. The US National Nanotechnology Initiative annual investment in research with educational and societal implications is estimated at about $30 million (of which National Science Foundation (NSF) awards about $23 million including contributions to student fellowships), and in nanoscale research with relevance to environment at about $50 million (of which NSF awards about $30 million and EPA about $6 million). An appeal is made to researchers and funding organizations worldwide to take timely and responsible advantage of the new technology for economic and sustainable development, to initiate societal implications studies from the beginning of the nanotechnology programs, and to communicate effectively the goals and potential risks with research users and the public.

The alignment of product strategy to supply chain practices of craft businesses in Gauteng Province, South Africa

Directory of Open Access Journals (Sweden)

Craig Voortman

2014-11-01

Full Text Available External factors such as blurring market boundaries, escalating customer diversity and increasing global competitive threats have forced businesses to build strategies around key products and formulate market-driven strategies that are integrated with relationship and supply chain strategies to deliver superior customer value. Indeed, in the modern era of supply chain management, organisations are getting more integrated with their suppliers and customers as a way to manage the total supply chain. The purpose of this research was to determine if product strategies and supply chain practices of small craft business are aligned. Personal in-depth interviews were conducted with nine craft businesses operating in Gauteng Province, South Africa. The findings revealed that craft businesses struggle to match their product strategies with their supply chain strategies. Craft businesses also exhibited some inbound supply chain weaknesses.

Archives and societal provenance Australian essays

CERN Document Server

Piggott, Michael

2012-01-01

Records and archival arrangements in Australia are globally relevant because Australia's indigenous people represent the oldest living culture in the world, and because modern Australia is an ex-colonial society now heavily multicultural in outlook. Archives and Societal Provenance explores this distinctiveness using the theoretical concept of societal provenance as propounded by Canadian archival scholars led by Dr Tom Nesmith. The book's seventeen essays blend new writing and re-workings of earlier work, comprising the fi rst text to apply a societal provenance perspective to a national sett

Growth, financial development, societal norms and legal institutions

NARCIS (Netherlands)

Garretsen, Harry; Lensink, Robert; Sterken, Elmer

2002-01-01

This paper analyses whether societal norms help to explain cross-country differences in financial development. We analyze whether societal norms in addition to legal institutions have an impact on financial development. We address the implications of the inclusion of societal norms for the analysis

Electron Beam Alignment Strategy in the LCLS Undulators

International Nuclear Information System (INIS)

Nuhn, H

2007-01-01

The x-ray FEL process puts very tight tolerances on the straightness of the electron beam trajectory (2 (micro)m rms) through the LCLS undulator system. Tight but less stringent tolerances of 80 (micro)m rms vertical and 140 (micro)m rms horizontally are to be met for the placement of the individual undulator segments with respect to the beam axis. The tolerances for electron beam straightness can only be met through beam-based alignment (BBA) based on electron energy variations. Conventional alignment will set the start conditions for BBA. Precision-fiducialization of components mounted on remotely adjustable girders and the use of beam-finder wires (BFW) will satisfy placement tolerances. Girder movement due to ground motion and temperature changes will be monitored continuously by an alignment monitoring system (ADS) and remotely corrected. This stabilization of components as well as the monitoring and correction of the electron beam trajectory based on BPMs and correctors will increase the time between BBA applications. Undulator segments will be periodically removed from the undulator Hall and measured to monitor radiation damage and other effects that might degrade undulator tuning

Alignment Strategy for Constricted Maxillary Dental Arch in Patients With Unilateral Cleft Lip and Palate Using Fixed Orthodontic Appliance.

Science.gov (United States)

Park, Yoon-Hee; Park, Sumin; Baek, Seung-Hak

2018-03-01

The purpose of this study was to compare the alignment pattern of the constricted maxillary dental arch by fixed orthodontic treatment (FOT) in the well-aligned and constricted arches of unilateral cleft lip and palate (UCLP) patients. 19 UCLP patients were divided into Group 1 (well-aligned arch, n = 9) and Group 2 (constricted arch, n = 10). After the cephalometric and maxillary dental arch variables before (T1) and after FOT (T2) were measured, statistical analysis was performed. There were no significant differences in the surgical timing of cheiloplasty, palatoplasty, and secondary alveolar bone grafting and in the surgical method of cheiloplasty between the 2 groups. However, Group 2 had a higher percentage of palatoplasty method, which could leave the denuded bone for secondary healing than Group 1 (P dental arch compared to Group 1 at the T1 stage (inter-second premolar width, greater segment angle [GSA], and lesser segment angle [LSA], all P dental arch shape, different strategy is necessary to obtain proper alignment by FOT.

The societal impact value of risk

International Nuclear Information System (INIS)

Simpson, D.E.

1995-04-01

A key ill-defined issue in the management and regulation of potentially hazardous conditions is that of the value to be associated with a reduction (or existence) of human health risks, such as radiation exposure or hazardous substance ingestion. Empirical observations of societal behavior patterns lead to a relationship for the quantitative value of societal risk impact which is consistent with general societal risk acceptance, is not inconsistent with ''de facto'' risk regulation, and is suitable and appropriate as a specification or guide for risk management and risk regulation. This societal risk impact expression is: Impact ($/year) = (8 x 10 7 ) NR i 4/3 where Ri = individual annual mortality risk; N = number of persons in the population sharing the risk and benefits. The change in Impact which can be derived from a regulation or risk management activity is the value of annual benefit which society would expect to forego (or annual equivalent cost to incur) in consideration of the activity

Societal response to nanotechnology: converging technologies–converging societal response research?

NARCIS (Netherlands)

Ronteltap, A.; Fischer, A.R.H.; Tobi, H.

2011-01-01

Nanotechnology is an emerging technology particularly vulnerable to societal unrest, which may hinder its further development. With the increasing convergence of several technological domains in the field of nanotechnology, so too could convergence of social science methods help to anticipate

What successful math teachers do, grades 6-12 80 research-based strategies for the common core-aligned classroom

CERN Document Server

Posamentier, Alfred S (Steven); Jaye, Daniel I

2013-01-01

The math teacher's go-to resource-now updated for the Common Core! What works in math and why has never been the issue; the research is all out there. Where teachers struggle is the "how." That's the big service What Successful Math Teachers Do provides.  It's a powerful portal to what the best research looks like in practice strategy by strategy-now aligned to both the Common Core and the NCTM Standards. For each of the book's 80 strategies, the authors present A brief description A summary of supporting research The corresponding NCTM and Common Core Standards Classroom applications Possible pitfalls Recommended reading and research.

Strategic alignment of Corporate Real Estate

NARCIS (Netherlands)

Appel - Meulenbroek, H.A.J.A.; Brown, M.G.; Ramakers, Y

2010-01-01

Purpose/value: With the growing complexity of organizations, it becomes increasingly important to tune the strategies of different business functions. In order to add maximum value to the organization, real estate strategies have to be aligned with corporate strategy. The purpose of this paper is to

How do we Take Care of Strategic Alignment?

DEFF Research Database (Denmark)

Simonsen, Jesper

1999-01-01

The article reviews the concept of ‘strategic alignment’ and presents the critique by Ciborra in SJIS (Vol. 9, No. 1) entitled “De profundis? Deconstructing the concept of strategic alignment”. We present a design approach that suggests how designers, conducting design projects in a specific orga...... environmental conditions, business strategies, and plans for IT are changing and hence challenge traditional approaches to strategic alignment. The results from the design project are described and related to IS literature and to Ciborra’s article.......The article reviews the concept of ‘strategic alignment’ and presents the critique by Ciborra in SJIS (Vol. 9, No. 1) entitled “De profundis? Deconstructing the concept of strategic alignment”. We present a design approach that suggests how designers, conducting design projects in a specific...... organization, can take care of and ensure that the design of IT is appropriately aligned with the organization’s overall business strategy. We describe a design project using this approach. The project presented took place in a small public organization. Focusing on alignment as part of the design process had...

IS ENVIRONMENTAL ALIGNMENT AND BUSINESS PERFORMANCE: A CONCEPTUAL APPROACH

Directory of Open Access Journals (Sweden)

K. Garg

2012-01-01

Full Text Available

ENGLISH ABSTRACT: This paper proposes a conceptual model termed "IS environmental alignment" that focuses on the support provided by IS strategy to minimize the gap between perceived environmental uncertainty and realized/objective environmental conditions. The model uses the Chan et al [9] alignment measurement method to measure IS strategic alignment as it provides a quantitative measure. In due course the proposed model would be tested in industry and would examine the affect of IS environmental alignment on business performance. The implication of the model lies in the effective use of deployed IS systems by organizations.

AFRIKAANSE OPSOMMING: 'n Konsepmodel word voorgelê wat handel oor "IS-omgewingsaanpassing". IS-strategie-ondersteuning by die minimisering van die gaping tussen waargenome omgewingsonsekerheid en gerealiseerde/objektiewe omgewingstoestande. Die model maak gebruik van die Chan et al [9] aanpassingsmeetmetode om IS-strategie-aanpassing op 'n kwantitatiewe basis te bepaal. Met die verloop van tyd sal die konsepmodel in die praktyk getoets word om te toon hoe IS-strategie-aanpassing sakevertoning affekteer. Die effektiewe ontplooiing van IS-stelsels by ondernemings word voorgehou.

The Influence Factors and Mechanism of Societal Risk Perception

Science.gov (United States)

Zheng, Rui; Shi, Kan; Li, Shu

Risk perception is one of important subjects in management psychology and cognitive psychology. It is of great value in the theory and practice to investigate the societal hazards that the public cares a lot especially in Socio-economic transition period. A survey including 30 hazards and 6 risk attributes was designed and distributed to about 2, 485 residents of 8 districts, Beijing. The major findings are listed as following: Firstly, a scale of societal risk perception was designed and 2 factors were identified (Dread Risk & Unknown Risk). Secondly, structural equation model was used to analyze the influence factors and mechanism of societal risk perception. Risk preference, government support and social justice could influence societal risk perception directly. Government support fully moderated the relationship between government trust and societal risk perception. Societal risk perception influenced life satisfaction, public policy preferences and social development belief.

Strategy for alignment of electron beam trajectory in LEReC cooling section

Energy Technology Data Exchange (ETDEWEB)

Seletskiy, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blaskiewicz, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Fedotov, A. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kayran, D. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kewisch, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Michnoff, R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Pinayev, I. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2016-09-23

We considered the steps required to align the electron beam trajectory through the LEReC cooling section. We devised a detailed procedure for the beam-based alignment of the cooling section solenoids. We showed that it is critical to have an individual control of each CS solenoid current. Finally, we modeled the alignment procedure and showed that with two BPM fitting the solenoid shift can be measured with 40 um accuracy and the solenoid inclination can be measured with 30 urad accuracy. These accuracies are well within the tolerances of the cooling section solenoid alignment.

Anticipating the Future, Influencing the Present: Assessing the Societal Implications of Emerging Technologies

Science.gov (United States)

Michelson, Evan S.

A growing challenge for the American policymaking system is to respond effectively to a wide range of interconnected, complex, long-term science and technology issues. Simultaneously, current approaches and institutions of governance are ill suited to address these multidimensional challenges. As the next generation of innovations in science and technology is arriving at an accelerating rate, the governance system is lagging behind. This realization leads to a vital overarching consideration that steers this study: What approaches are well suited to anticipate the longer-term societal implications of emerging technologies in the 21st Century? This study identifies and examines strategies for anticipating the longer-term societal implications of emerging technologies by way of a qualitative case study. It explores one area of technology (nanotechnology), in one particular governance system (the United States), and with a focus on one high profile non-governmental organization (NGO) involved in addressing a range of nanotechnology's societal and policy implications: the Project on Emerging Nanotechnologies (PEN). Based at the Woodrow Wilson International Center for Scholars, PEN's goal was to ensure "that as nanotechnologies advance, possible risks are minimized, public and consumer engagement remains strong, and the potential benefits of these new technologies are realized." The conceptual framework of anticipatory governance guides the research, which offers a real-world example about how anticipatory governance applies in the nongovernmental sector and shows how this idea links to broader theoretical debates about the policymaking process. The study's main conclusion is that PEN utilized a set of interconnected strategies related to advancing foresight, operating in a boundary-spanning role, and promoting communications and public engagement in its attempt to influence, anticipate, and shape the societal implications of emerging technologies. The findings are

Gauging the societal impacts of natural disasters using a capability approach.

Science.gov (United States)

Gardoni, Paolo; Murphy, Colleen

2010-07-01

There is a widely acknowledged need for a single composite index that provides a comprehensive picture of the societal impact of disasters. A composite index combines and logically organizes important information policy-makers need to allocate resources for the recovery from natural disasters; it can also inform hazard mitigation strategies. This paper develops a Disaster Impact Index (DII) to gauge the societal impact of disasters on the basis of the changes in individuals' capabilities. The DII can be interpreted as the disaster impact per capita. Capabilities are dimensions of individual well-being and refer to the genuine opportunities individuals have to achieve valuable states and activities (such as being adequately nourished or being mobile). After discussing the steps required to construct the DII, this article computes and compares the DIIs for two earthquakes of similar magnitude in two societies at different levels of development and of two disasters (earthquake and wind storm) in the same society.

Societal health and urban sustainability indicators

Energy Technology Data Exchange (ETDEWEB)

Petrich, C.H.; Tonn, B.E.

1996-08-27

Without the social will, no city can successfully Undertake the planning and programs necessary for meaningful progress toward sustainability. Social will derives from wellsprings of vital societal health. This paper presents an approach to helping cities in APEC member economies initiate a program for developing indicators of sustainability. Representative indicators of social capital and other aspects of civic engagement, as proxies for societal health, are presented.

An aligned porous electrospun fibrous membrane with controlled drug delivery - An efficient strategy to accelerate diabetic wound healing with improved angiogenesis.

Science.gov (United States)

Ren, Xiaozhi; Han, Yiming; Wang, Jie; Jiang, Yuqi; Yi, Zhengfang; Xu, He; Ke, Qinfei

2018-04-01

A chronic wound in diabetic patients is usually characterized by poor angiogenesis and delayed wound closure. The exploration of efficient strategy to significantly improve angiogenesis in the diabetic wound bed and thereby accelerate wound healing is still a significant challenge. Herein, we reported a kind of aligned porous poly (l-lactic acid) (PlLA) electrospun fibrous membranes containing dimethyloxalylglycine (DMOG)-loaded mesoporous silica nanoparticles (DS) for diabetic wound healing. The PlLA electrospun fibers aligned in a single direction and there were ellipse-shaped nano-pores in situ generated onto the surface of fibers, while the DS were well distributed in the fibers and the DMOG as well as Si ion could be controlled released from the nanopores on the fibers. The in vitro results revealed that the aligned porous composite membranes (DS-PL) could stimulate the proliferation, migration and angiogenesis-related gene expression of human umbilical vein endothelial cells (HUVECs) compared with the pure PlLA membranes. The in vivo study further demonstrated that the prepared DS-PL membranes significantly improved neo-vascularization, re-epithelialization and collagen formation as well as inhibited inflammatory reaction in the diabetic wound bed, which eventually stimulated the healing of the diabetic wound. Collectively, these results suggest that the combination of hierarchical structures (nanopores on the aligned fibers) with the controllable released DMOG drugs as well as Si ions from the membranes, which could create a synergetic effect on the rapid stimulation of angiogenesis in the diabetic wound bed, is a potential novel therapeutic strategy for highly efficient diabetic wound healing. A chronic wound in diabetic patients is usually characterized by the poor angiogenesis and the delayed wound closure. The main innovation of this study is to design a new kind of skin tissue engineered scaffold, aligned porous poly (l-lactic acid) (PlLA) electrospun

Public Leadership and processes of societal innovations

NARCIS (Netherlands)

Termeer, C.J.A.M.

2007-01-01

Societal actors can come against problems that cross the traditional boundaries of sectors, organisations and routines. Processes of societal innovation are started on the way to an unknown future, creating new solutions and new corporations. In this paper I focus on the question how public leaders

Strategic alignment of the South African retail sector with the national development plan

Directory of Open Access Journals (Sweden)

Roger B Mason

2014-12-01

Full Text Available This paper provides an evaluation of the strategy alignment of the South African retail sector with the National Development Plan (NDP governance values and objectives. The paper considers the commercial realities which form the framework for retail decision-makers when they address the challenges in aligning their business growth strategies with the regulatory framework of a capable, developmental state. Within that context, the outcomes of a retail stakeholder alignment study of the NDP strategy themes are analysed. The method involved a policy survey of a purposive sample of retail business and governance stakeholders. The survey findings reflect retailer alignment with many NDP regulatory and ‘active citizenry’ strategies, but with strong beliefs that others are not the retail business sector’s governance responsibility.

STELLAR: fast and exact local alignments

Directory of Open Access Journals (Sweden)

Weese David

2011-10-01

Full Text Available Abstract Background Large-scale comparison of genomic sequences requires reliable tools for the search of local alignments. Practical local aligners are in general fast, but heuristic, and hence sometimes miss significant matches. Results We present here the local pairwise aligner STELLAR that has full sensitivity for ε-alignments, i.e. guarantees to report all local alignments of a given minimal length and maximal error rate. The aligner is composed of two steps, filtering and verification. We apply the SWIFT algorithm for lossless filtering, and have developed a new verification strategy that we prove to be exact. Our results on simulated and real genomic data confirm and quantify the conjecture that heuristic tools like BLAST or BLAT miss a large percentage of significant local alignments. Conclusions STELLAR is very practical and fast on very long sequences which makes it a suitable new tool for finding local alignments between genomic sequences under the edit distance model. Binaries are freely available for Linux, Windows, and Mac OS X at http://www.seqan.de/projects/stellar. The source code is freely distributed with the SeqAn C++ library version 1.3 and later at http://www.seqan.de.

A Psycho-Societal Approach

DEFF Research Database (Denmark)

Mellon, Karsten

This is a project about Danish vocational bachelor students admitted on the basis of an Individual Competency Assessment (VPL/IKV) in light of a Psycho-Societal Approach. The core idea of this paper is to present a PhD project which aims to contribute findings regarding students enrolled in a Dan...... in a Danish vocational Bachelor’s education program (teachers program under the frame of University College) through Validation of Prior Learning by the use of an Individual Competencies Assessment (VPL/IKV).......This is a project about Danish vocational bachelor students admitted on the basis of an Individual Competency Assessment (VPL/IKV) in light of a Psycho-Societal Approach. The core idea of this paper is to present a PhD project which aims to contribute findings regarding students enrolled...

PROSPECTIVE LEADERS' VIEW ON ROMANIAN SOCIETAL CULTURE

Directory of Open Access Journals (Sweden)

CATANA GHEORGHE ALEXANDRU

2010-07-01

Full Text Available This study deals with Romanian prospective leaders’ perceptions and expectations concerning the societal culture. It is a part of a European research project, GLOBE Students, dealing with the interrelations between societal culture and leadership. The basic theoretical constructs and methodological framework of investigation are those developed by GLOBE international research project. In adapting our research to student population peculiarities, GLOBE Beta questionnaire was altered through adding new items (scales. The sample consists in 429 students in business/economics and engineering, belonging to three Romanian universities. The findings show that in student’s opinion there are significant differences between societal culture practices and values (expectations on all nine cultural dimensions in GLOBE model.

Ethical issues and societal expectations

International Nuclear Information System (INIS)

Metlay, D.

2010-01-01

Daniel Metlay (NWTRB) declared that institutions had always recognised an ethical obligation to manage high- level radioactive waste in unprecedented ways. This obligation has not only endured, but has become more explicit and multidimensional and it now subsumed under a more general rubric of 'societal expectations'. D. Metlay directed attention toward the proceedings of previous RWMC-RF workshop ', which contains five essays, authored by Kjell Andersson, Andrew Blowers, Carl-Reinhold Braakenhielm, Francois Dermange, and Patricia Fleming, that are relevant to the question of ethical issues and societal expectations. D. Metlay observed that 'societal expectations' are hard to define and thus very hard to measure. They may vary considerably with time and from country to country. As an illustration he referred to an inquiry performed by a task group 30 years ago in a document entitled 'Proposed Goals for Radioactive Waste Management' (NUREG-0300) on behalf of the U.S. Nuclear Regulatory Commission. Conclusions from D. Metlay are that, for the most part, societal expectations in the United States appear to be quite stable over a period of more than 30 years. In two areas, however, there are clear differences in emphasis between expectations articulated in the last few years and those recorded in 1978. (1) While then there was emphasis on the operational reliability of organisations and institutions. In particular, much care was taken to discuss the inherent limitations on bureaucratic error-correction in the future. The focus is nowadays more on bureaucratic behaviours associated with carrying out decision-making processes in the present. (2) While there is current emphasis on the importance of trust, transparency, and accountability, the NRC document may cast some doubt on the reliability of a stepwise decision-making process. In the domain of radioactive waste management, error signals are notoriously unclear, and strong disagreements over objectives and value trade

Influencing governance of a public-private partnership in plant genomics: The societal interface group as a new instrument for public involvement.

Science.gov (United States)

Hanssen, Lucien; Gremmen, Bart

2013-08-01

The Centre for BioSystems Genomics (CBSG) is a Dutch public-private partnership in plant genomics active in potato and tomato research and exploitation. Its Societal Interface Group (SIG) has been developed to inform its communication strategy and governance practice. This new instrument identifies and discusses early signals from society by bringing together people from different societal backgrounds with members of CBSG management. This interactive learning process facilitates the inclusion of public concerns and needs in scientific developments in the field of plant genomics, and simultaneously enables genomics scientists to search for more societal aims, meanings, and starting points for their research agenda. Analysis of the SIG sessions revealed that the input of public expertise is not threatening or irrational, but provides the opportunity to harness the creative potential of future users highly relevant for the development of societal practices in which plant genomics plays a role.

PENGUKURAN TINGKAT KEMATANGAN PENYELARASAN STRATEGI TEKNOLOGI INFORMASI TERHADAP STRATEGI BISNIS ANALISIS MENGGUNAKAN FRAMEWORK COBIT 4.1 (Studi Kasus PT. BRI, Tbk

Directory of Open Access Journals (Sweden)

Adityawarman Adityawarman

2012-05-01

Full Text Available Strategic alignment between Information Technology (IT and business has become CIOs andCEOs primary concern nowadays. This shows that strategic alignment is needed to achievebusiness goals. Every function in organization have their own strategies in achieving there goal,these strategies should fit each other and aligned. The same thing should happen in the strategiesof IT in organization, IT strategy should in harmony with business strategy. One of the mainissues for the next step is how to asses the maturity level of strategic alignment. By knowing thestrategic alignment level, organization should be able to identify its current position, and decidewhat practices shoud perform in order to achieve continuous improvement. The assessment ofstrategic alignment maturity level as a tool for assessing alignment level of IT strategy withbusiness strategy. This research assesses maturity alignment level of IT strategy with businessstrategy at PT. Bank BRI, Tbk, using IT Strategic Plan 2003–2008 as a framework and usingCOBIT 4.1 maturity model for assessment. Result of this research shows that level of maturityalignment of IT strategy with business strategy approaching defined level at 2.90 score. The resultshows that procedures have been standardized and documented, and communicated throughtraining. It is mandated that these processes should be followed. However, it is unlikely thatdeviations will be detected. The procedures themselves are not sophisticated but are theformalization of existing practices. Keywords:business, IT strategic alignment, COBIT 4.1 maturity model, IT balance scorecard, strategicalignment measurement, maturity measurement.

Investigating the Supply Chain Strategies and Information System Strategies Alignment and its Effects on Supply Chain Management Performance (Case Study: Manufacturing Firms in Khuzestan Province, Iran

Directory of Open Access Journals (Sweden)

Belghis Bavarsad

2016-12-01

Full Text Available The purpose of the present study is to investigate the supply chain strategies and information system strategies alignment and the impact of these two strategies on supply chain management performance of manufacturing firms in Khuzestan province. The population of this applied research consisted of 1716 manufacturing firms and with using Cochran's formula for limited society, 231 firms were selected. Statistical unit of society were the purchasing / logistic managers of said firms and research questionnaire was distributed to them for each firm. The data collection instrument is Qrunfleh (2010 questionnaire, which its content validity was evaluated through experts and academics and its construct validity was confirmed through confirmatory factor analysis. Structural equation models and SPSS 22 have been used in order to analysis the data. The results showed that, all components of supply chain strategies (lean, agile and hybrid have a positive and significant impact on supply chain management performance and the moderate role of Information system strategies (efficient, flexible and comprehensive on supply chain management Performance also conformed.

Ultrasonic inspections of fuel alignment pins

International Nuclear Information System (INIS)

Rathgeb, W.; Schmid, R.

1994-01-01

As a remedy to the practical problem of defects in fuel alignment pins made of Inconel X750, an inspection technique has been developed which fully meets the requirements of detecting defects. The newly used fuel alignment pins made of austenite are easy to test and therefore satisfy the necessity of further inspections.For the fuel alignment pins of the upper core structure a safe and fast inspection technique was made available. The inspection sensitivity is high and it is possible to give quantitative directions concerning defect orientation and depth. After the required inspections had been concluded in 1989, a total of 18 inspections were carried out in various national and international nuclear power plants in the following years. During this time more than 6000 fuel alignment pines were examined.For the fuel alignment pins the inspection technique provided could increase the understanding of the defect process. This technique contributed to the development of an adaptive and economical repair strategy. ((orig.))

The Societal Nature of Subjectivity

DEFF Research Database (Denmark)

Olesen, Henning Salling

2013-01-01

The HSR Focus presents a psycho-societal approach to qualitative empirical research in several areas of everyday social life. It is an approach which integrates a theory of subjectivity and an interpretation methodology which integrates hermeneutic experiences from text analysis and psychoanalysis....... In terms of methodology it revives the themes originally launched in FOS exactly ten years ago: "Subjectivity and Reflectivity in Qualitative Research" (Breuer, Mruck and Roth 2002; Mruck and Breuer 2003). This editorial introduction presents the intellectual background of the psycho-societal methodology......, reflects on its relevance and critical perspectives in a contemporary landscape of social science, and comments the way in which an international and interdisciplinary research group has developed this approach to profane empirical research....

Children's proximal societal conditions

DEFF Research Database (Denmark)

Stanek, Anja Hvidtfeldt

2018-01-01

that is above or outside the institutional setting or the children’s everyday life, but something that is represented through societal structures and actual persons participating (in political ways) within the institutional settings, in ways that has meaning to children’s possibilities to participate, learn...... and develop. Understanding school or kindergarten as (part of) the children’s proximal societal conditions for development and learning, means for instance that considerations about an inclusive agenda are no longer simply thoughts about the school – for economic reasons – having space for as many pupils...... as possible (schools for all). Such thoughts can be supplemented by reflections about which version of ‘the societal’ we wish to present our children with, and which version of ‘the societal’ we wish to set up as the condition for children’s participation and development. The point is to clarify or sharpen...

A MEMORY EFFICIENT HARDWARE BASED PATTERN MATCHING AND PROTEIN ALIGNMENT SCHEMES FOR HIGHLY COMPLEX DATABASES

OpenAIRE

Bennet, M.Anto; Sankaranarayanan, S.; Deepika, M.; Nanthini, N.; Bhuvaneshwari, S.; Priyanka, M.

2017-01-01

Protein sequence alignment to find correlation between different species, or genetic mutations etc. is the most computational intensive task when performing protein comparison. To speed-up the alignment, Systolic Arrays (SAs) have been used. In order to avoid the internal-loop problem which reduces the performance, pipeline interleaving strategy has been presented. This strategy is applied to an SA for Smith Waterman (SW) algorithm which is an alignment algorithm to locally align two proteins...

Corporate real estate alignment strategies in dutch higher education

NARCIS (Netherlands)

Theo van der Voordt; Ronald Beckers

2014-01-01

This paper aims to explore the management approaches concerned with the process of aligning Corporate Real Estate (CRE) with organizational goals on a strategic level and regarding day-to-day operating activities in higher education institutes.

Differences Between Individual and Societal Health State Valuations

Science.gov (United States)

Chapman, Benjamin P.; Franks, Peter; Duberstein, Paul R.; Jerant, Anthony

2009-01-01

Objective The concept of “adaptation” has been proposed to account for differences between individual and societal valuations of specific health states in patients with chronic diseases. Little is known about psychological indices of adaptational capacity, which may predict differences in individual and societal valuations of health states. We investigated whether such differences were partially explained by personality traits in chronic disease patients. Research Design Analysis of baseline data of randomized controlled trial. Subjects Three hundred seventy patients with chronic disease. Measures The NEO-five factor inventory measure of personality, EuroQoL-5D (EQ-5D) societal-based, and the EQ visual analogue scale individually-based measures of health valuation. Results Regression analyses modeled Dev, a measure of difference between the EQ-Visual Analogue Scale and EQ-5D, as a function of personality traits, sociodemographic factors, and chronic diseases. Individual valuations were significantly and clinically higher than societal valuations among patients in the second and third quartile of conscientiousness (Dev = 0.08, P = 0.01); among covariates, only depression (Dev = -0.04, P = 0.046) was also associated with Dev. Conclusion Compared with societal valuations of a given health state, persons at higher quartiles of conscientiousness report less disutility associated with poor health. The effect is roughly twice that of some estimates of minimally important clinical differences on the EQ-5D and of depression. Although useful at the aggregate level, societal preference measures may systematically undervalue the health states of more conscientious individuals. Future work should examine the impact this has on individual patient outcome evaluation in clinical studies. PMID:19543121

Business-IT Alignment in Trade Facilitation: A Case Study

Science.gov (United States)

Adaba, Godfried; Rusu, Lazar; El-Mekawy, Mohamed

In the information age, no organization can thrive without harnessing the power of IT. The effective deployment of IT to achieve business goals and gain competitive advantage requires the alignment of business and IT strategies of organizations. Using the Strategic Alignment Maturity model, this paper evaluates strategic alignment maturity of Customs Excise Preventive service, a frontline public organization charged with trade facilitation in Ghana. Strategic alignment maturity is at level 3; which implies the existence of an established process to leverage IT for efficiency and effectiveness. Efforts are required to strengthen alignment and fully harness the potential of IT to facilitate trade in Ghana.

Georgia science curriculum alignment and accountability: A blueprint for student success

Science.gov (United States)

Reining-Gray, Kimberly M.

Current trends and legislation in education indicate an increased dependency on standardized test results as a measure for learner success. This study analyzed test data in an effort to assess the impact of curriculum alignment on learner success as well as teacher perceptions of the changes in classroom instruction due to curriculum alignment. Qualitative and quantitative design methods were used to determine the impact of science curriculum alignment in grades 9-12. To determine the impact of science curriculum alignment from the Quality Core Curriculum (QCC) to the Georgia Performance Standards (GPS) test data and teacher opinion surveys from one Georgia School system were examined. Standardized test scores before and after curriculum alignment were analyzed as well as teacher perception survey data regarding the impact of curriculum change. A quantitative teacher perception survey was administered to science teachers in the school system to identify significant changes in teacher perceptions or teaching strategies following curriculum realignment. Responses to the survey were assigned Likert scale values for analysis purposes. Selected teachers were also interviewed using panel-approved questions to further determine teacher opinions of curriculum realignment and the impact on student success and teaching strategies. Results of this study indicate significant changes related to curriculum alignment. Teachers reported a positive change in teaching strategies and instructional delivery as a result of curriculum alignment and implementation. Student scores also showed improvement, but more research is recommended in this area.

The alignment system of the ATLAS muon end-cap spectrometer

International Nuclear Information System (INIS)

Schricker, A.

2002-08-01

The Large Hadron Collider at CERN will offer an unparalleled opportunity to probe fundamental physics at an energy scale well beyond that reached by current experiments. The ATLAS detector is being designed to fully exploit the potential of the LHC for revealing new aspects of the fundamental structure of nature. The muon spectrometer itself must measure with a momentum resolution of s10 % for muons with a transverse momentum of p T =1TeV, to fully exploit the advantages offered by the open superconducting air core muon toroid magnet system. At this level of momentum resolution the muon spectrometer relies heavily on the ability to master the alignment of the large muon chambers spaced far apart. The overall contribution of the alignment to the total sagitta error must be less than 30 μm r.m.s. In order to meet the stringent alignment requirements the positions of the muon chambers are constantly monitored with optical alignment technologies. The end-caps of this spectrometer are therefore embedded in an alignment grid that must allow for an absolute position measurement of the chambers. This alignment grid employs up to 9.6m long precision rulers (alignment bars) which have to provide the position and orientation of all alignment sensors permeating the end-caps. Simulation studies have shown that the shape of these bars must be known to 30 μm r.m.s. and the length must be known to 20 μm r.m.s. The principles of alignment and survey techniques used to do this are introduced and the current activities concerning the alignment strategy for the ATLAS muon end-cap spectrometer are presented. After consideration of the motivation and requirements, the measurement strategy and the design of the alignment bars is given. An optical and thermal in-bar instrumentation is used to provide shape information of discrete points on the bar. The strategy to calibrate the in-bar instrumentation and to measure an initial bar shape with a large coordinate measuring machine, leads

Assessing and Responding to the Risks of Global and Societal Changes in the MENA Region

Science.gov (United States)

Lange, Manfred

2017-04-01

combined risks posed by the MENA region being considered a climatic and a societal "hot spot", as described above. These risks will have to be effectively communicated to stakeholders and the research community in order to outline, specify and implement research towards efficacious mitigation and adaption strategies aimed to minimize adverse effects of challenges posed by global and societal changes in the MENA region. The paper will describe the current state of advancing such a process and will introduce a first draft of a "Future Earth Research Strategy for the MENA Region", as formulated by the FEMRC and its Regional Advisory Committee.

Can value-based insurance impose societal costs?

Science.gov (United States)

Koenig, Lane; Dall, Timothy M; Ruiz, David; Saavoss, Josh; Tongue, John

2014-09-01

Among policy alternatives considered to reduce health care costs and improve outcomes, value-based insurance design (VBID) has emerged as a promising option. Most applications of VBID, however, have not used higher cost sharing to discourage specific services. In April 2011, the state of Oregon introduced a policy for public employees that required additional cost sharing for high-cost procedures such as total knee arthroplasty (TKA). Our objectives were to estimate the societal impact of higher co-pays for TKA using Oregon as a case study and building on recent work demonstrating the effects of knee osteoarthritis and surgical treatment on employment and disability outcomes. We used a Markov model to estimate the societal impact in terms of quality of life, direct costs, and indirect costs of higher co-pays for TKA using Oregon as a case study. We found that TKA for a working population can generate societal benefits that offset the direct medical costs of the procedure. Delay in receiving surgical care, because of higher co-payment or other reasons, reduced the societal savings from TKA. We conclude that payers moving toward value-based cost sharing should consider consequences beyond direct medical expenses. Copyright © 2014 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

A psycho-societal approach to life histories

DEFF Research Database (Denmark)

Olesen, Henning Salling

2016-01-01

Life histories represent lived lives past, present and anticipated future. As such they are interpretations of individuals’ experiences of the way in which societal dynamics take place in the individual body and mind, either by the individual him/herself or by another biographer. I have been...... particularly interested in the relations between the culturally mediated and the sensory/bodily aspects of experience processes because this is the boundary zones of knowledge and seat of the dynamics of learning. My psycho-societal approach was developing from interpreting autobiographical and later certain...... other forms of language interactive material as moments of life history, i.e. it is basically a hermeneutic approach. Talking about a psycho-societal approach indicates the ambition of attacking the dichotomy of the social and the psychic, both in the interpretation procedure and in some main...

Alignment of Human Resource Practices and Teacher Performance Competency

Science.gov (United States)

Heneman III, Herbert G.; Milanowski, Anthony T.

2004-01-01

In this article, we argue that human resource (HR) management practices are important components of strategies for improving student achievement in an accountability environment. We present a framework illustrating the alignment of educational HR management practices to a teacher performance competency model, which in turn is aligned with student…

Information Technology Governance Maturity: Examining the Moderating Effect on the Relationship between Strategic Alignment Maturity and Information Technology Effectiveness

Science.gov (United States)

Kouakou, Claude N.

2013-01-01

The positive contribution of information technology (IT) in an organization is undeniable. Most organizations take advantage of that contributive benefit by aligning their business strategy with their IT strategy. This alignment is known as IT-business strategic alignment. Strategic alignment involves making the best possible use of corporate IT…

Alignment performance monitoring for ASML systems

Science.gov (United States)

Chung, Woong-Jae; Temchenko, Vlad; Hauck, Tarja; Schmidt, Sebastian

2006-03-01

In today's semiconductor industry downscaling of the IC design puts a stringent requirement on pattern overlay control. Tighter overlay requirements lead to exceedingly higher rework rates, meaning additional costs to manufacturing. Better alignment control became a target of engineering efforts to decrease rework rate for high-end technologies. Overlay performance is influenced by known parameters such as "Shift, Scaling, Rotation, etc", and unknown parameters defined as "Process Induced Variation", which are difficult to control by means of a process automation system. In reality, this process-induced variation leads to a strong wafer to wafer, or lot to lot variation, which are not easy to detect in the mass-production environment which uses sampling overlay measurements for only several wafers in a lot. An engineering task of finding and correcting a root cause for Process Induced Variations of overlay performance will be greatly simplified if the unknown parameters could be tracked for each wafer. This paper introduces an alignment performance monitoring method based on analysis of automatically generated "AWE" files for ASML scanner systems. Because "AWE" files include alignment results for each aligned wafer, it is possible to use them for monitoring, controlling and correcting the causes of "process induced" overlay performance without requiring extra measurement time. Since "AWE" files include alignment information for different alignment marks, it is also possible to select and optimize the best alignment recipe for each alignment strategy. Several case studies provided in our paper will demonstrate how AWE file analysis can be used to assist engineer in interpreting pattern alignment data. Since implementing our alignment data monitoring method, we were able to achieve significant improvement of alignment and overlay performance without additional overlay measurement time. We also noticed that the rework rate coming from alignment went down and

Corporate real estate alignment strategies in Dutch higher education

NARCIS (Netherlands)

Theo van der Voordt; Ronald Beckers

2014-01-01

Purpose – This paper aims to explore the management approaches concerned with the process of aligning Corporate Real Estate (CRE) with organizational goals on a strategic level and regarding day-to-day operating activities in higher education institutes. Methodology/approach – The paper first

The societal costs of insomnia

Directory of Open Access Journals (Sweden)

Alan G Wade

2010-12-01

Full Text Available Alan G WadeCPS Research, Glasgow, ScotlandObjective: Insomnia can be broadly defined as difficulty initiating or maintaining sleep, or sleep that is not refreshing or of poor quality with negative effect on daytime function. Insomnia can be a primary condition or comorbid to an underlying disorder. Subjective measures of insomnia used in population studies, usually based on complaints of unsatisfactory sleep, put the prevalence at about 10%. Insomnia is more common in the elderly and in women, and is often associated with medical and psychiatric disorders. This review examines the measures used to assess quality of sleep (QOS and daytime functioning and the impact of insomnia on society using these measures.Methods: Literature searches were performed to identify all studies of insomnia (primary and comorbid in adults (aged 18–64 years and the elderly (aged ≥ 65 years with baseline and/or outcomes relating to QOS or daytime functioning. The impact of poor QOS on quality of life (QOL, psychomotor and cognitive skills, health care resource utilization, and other societal effects was examined.Results: Although definitions and measurement scales used to assess sleep quality vary widely, it is clear that the societal consequences of insomnia are substantial and include impaired QOL and increased health care utilization. The impact of poor QOS and impaired daytime functioning common in insomnia can lead to indirect effects such as lower work productivity, increased sick leave, and a higher rate of motor vehicle crashes.Conclusions: Insomnia is associated with substantial direct and indirect costs to society. It is almost impossible to separate the costs associated with primary and comorbid insomnia. More studies are required which control for the severity of any primary disorder to accurately evaluate the costs of comorbid insomnia. Development of standardized diagnostic and assessment scales will enable more accurate quantification of the true

Aligning Mathematical Tasks to the Common Core Standards for Mathematical Practice

OpenAIRE

Johnson, Raymond

2016-01-01

How do algebra teachers align mathematical tasks to the CCSSM Standards of Mathematical Practice? Using methods of design-based implementation research, we identified difficulties of alignment to practices and developed strategies identifying high-quality tasks.

Societal transformation and adaptation necessary to manage dynamics in flood hazard and risk mitigation (TRANS-ADAPT)

Science.gov (United States)

Fuchs, Sven; Thaler, Thomas; Bonnefond, Mathieu; Clarke, Darren; Driessen, Peter; Hegger, Dries; Gatien-Tournat, Amandine; Gralepois, Mathilde; Fournier, Marie; Mees, Heleen; Murphy, Conor; Servain-Courant, Sylvie

2015-04-01

Facing the challenges of climate change, this project aims to analyse and to evaluate the multiple use of flood alleviation schemes with respect to social transformation in communities exposed to flood hazards in Europe. The overall goals are: (1) the identification of indicators and parameters necessary for strategies to increase societal resilience, (2) an analysis of the institutional settings needed for societal transformation, and (3) perspectives of changing divisions of responsibilities between public and private actors necessary to arrive at more resilient societies. This proposal assesses societal transformations from the perspective of changing divisions of responsibilities between public and private actors necessary to arrive at more resilient societies. Yet each risk mitigation measure is built on a narrative of exchanges and relations between people and therefore may condition the outputs. As such, governance is done by people interacting and defining risk mitigation measures as well as climate change adaptation are therefore simultaneously both outcomes of, and productive to, public and private responsibilities. Building off current knowledge this project will focus on different dimensions of adaptation and mitigation strategies based on social, economic and institutional incentives and settings, centring on the linkages between these different dimensions and complementing existing flood risk governance arrangements. The policy dimension of adaptation, predominantly decisions on the societal admissible level of vulnerability and risk, will be evaluated by a human-environment interaction approach using multiple methods and the assessment of social capacities of stakeholders across scales. As such, the challenges of adaptation to flood risk will be tackled by converting scientific frameworks into practical assessment and policy advice. In addressing the relationship between these dimensions of adaptation on different temporal and spatial scales, this

The Alignment of Pay-For-Performance with the Strategy in Environment of Balanced Scorecard

Directory of Open Access Journals (Sweden)

Kleber Albuquerque de Vasconcelos

2013-09-01

Full Text Available According to Kaplan and Norton (1997 a fixed compensation no longer meets the diverse expectations of reward and remuneration of staff. In this scenario, the economic agents seek business management tools that allow connecting individual performance to organizational performance. Taking these in considerations, this study aims to analyze if the criteria for the use of pay-for-performance is in accordance with the organization's strategy expressed by the indicators and goals used in the Balanced Scorecard (BSC. A qualitative approach was through a field survey of descriptive character, using, for data collection, a structured questionnaire with open and closed questions. The sample consists of 17 Brazilian companies in three business segments (heavy construction, industry and technology / services and leaders in the market in which they operate. The results showed that, although it was clear the use of indicators associated with the use of BSC, the pay-for-performance models studied did not included in a balanced way, the indicators associated with BSC. There is a dissonance between corporate rhetoric and practice and mainly, the non-recognition of compensation management as a tool for alignment and support business strategies

Societal output and use of research performed by health research groups

Directory of Open Access Journals (Sweden)

van Ark Gerrit

2010-10-01

Full Text Available Abstract The last decade has seen the evaluation of health research pay more and more attention to societal use and benefits of research in addition to scientific quality, both in qualitative and quantitative ways. This paper elaborates primarily on a quantitative approach to assess societal output and use of research performed by health research groups (societal quality of research. For this reason, one of the Dutch university medical centres (i.e. the Leiden University Medical Center (LUMC was chosen as the subject of a pilot study, because of its mission to integrate top patient care with medical, biomedical and healthcare research and education. All research departments were used as units of evaluation within this university medical centre. The method consisted of a four-step process to reach a societal quality score per department, based on its (research outreach to relevant societal stakeholders (the general public, healthcare professionals and the private sector. For each of these three types of stakeholders, indicators within four modes of communication were defined (knowledge production, knowledge exchange, knowledge use and earning capacity. These indicators were measured by a bottom-up approach in a qualitative way (i.e. all departments of the LUMC were asked to list all activities they would consider to be of societal relevance, after which they were converted into quantitative scores. These quantitative scores could then be compared to standardised scientific quality scores that are based on scientific publications and citations of peer-reviewed articles. Based on the LUMC pilot study, only a weak correlation was found between societal and scientific quality. This suggests that societal quality needs additional activities to be performed by health research groups and is not simply the consequence of high scientific quality. Therefore we conclude that scientific and societal evaluation should be considered to be synergistic in terms

Does alignment of constructivist teaching, curriculum, and assessment strategies promote meaningful learning?

Science.gov (United States)

Jimarez, Teresa

Despite our national efforts to attract more students to the science, technology, engineering, and mathematics (STEM) fields, the number of students continues to be small. Empirical studies have suggested that in order to actively engage students in the science learning processes, lessons need to be designed which consider student prior experiences and provide a sound curriculum, within an environment promoting social interaction---that is, allowing for sharing and negotiation of those ideas which promote reflective thinking. These premises require an embedded assessment system that continuously provides feedback to both student and teacher. This technique allows adaptation and modification of lessons to better facilitate conceptual understanding. This study focused on the use of constructivist strategies that, when aligned, promoted conceptual understanding while facilitating development of science process skills. Skill development leads to meaningful learning, known to promote a change of attitude toward science. A mixed research design embedded in a case study approach was used to understand the complexity of the variables examined in this study. Both quantitative and qualitative methods of data collection were used to strengthen the validity and interpretation of the findings. Students from one of three ninth-grade physical science classes were selected for this study. The students numbered 29, 13 boys and 16 girls; the majority of these students were of Hispanic background. The analysis of data suggested that the use of constructivist strategies promotes conceptual understanding of science concepts and development of science process skills and a change of attitude towards science. This study concluded that selecting teaching and multiple assessment strategies is vital to engage students in science careers. Due to the limited nature of this case study, the researcher recommends a replication or followup with a different teacher and school, including a control

Energy Saving Alignment Strategy: Achieving energy efficiency in urban buildings by matching occupant temperature preferences with a building’s indoor thermal environment

International Nuclear Information System (INIS)

Xu, Xiaoqi; Culligan, Patricia J.; Taylor, John E.

2014-01-01

Highlights: • A novel strategy for energy savings in multi-family buildings is presented. • A household’s thermal preferences are matched with a unit’s thermal environment. • Potential energy savings are examined using public housing as a test case. • 2.1–42.0% primary energy savings are shown, depending on climate location. - Abstract: Existing strategies for residential energy savings through physical renovation or motivating occupant energy conservation behavior can be costly and/or have transitory effects. Focusing on multi-family dwellings, an important subset of the urban residential sector, we propose an Energy Saving Alignment Strategy (ESAS) that has advantageous cost-effectiveness and a long-lasting influence. By aligning the distribution of residents’ thermostat preferences with the indoor temperature, ESAS aims to maximize thermal comfort and, accordingly, energy savings in multi-family buildings where indoor temperatures vary between apartments as a function of apartment orientation and floor level. Using a case study of a 1084-apartment public housing complex in New York, we classify both occupants’ thermostat preferences and apartments’ operative temperatures into five groups, and optimize energy efficiency by assigning each group of occupants to the group of apartments that best aligns with their thermostat preference. We test ESAS in eight cities representing all four U.S. census regions and six climate zones. Simulation results reveal 2.1–42.0% in energy savings compared to random apartment assignments depending on geographic location, with the highest energy reductions occurring in cities with mild climates, where the range of occupant thermostat preferences coincides with the natural indoor temperature range. We conclude by providing suggested guidelines on how ESAS might work in practice, and recommendations for extending ESAS research

HOW FUTURE MANAGERS VIEW SOCIETAL CULTURE: A CROSS-COUNTRY COMPARISON

OpenAIRE

CATANA DOINA; CATANA GHEORGHE ALEXANDRU

2011-01-01

Our study aims at enriching the existing literature about the prospective managers view of an ideal societal value system and the existing cultural practices in their society. The findings about the students' perception on cultural practices and their expectations about societal culture are helpful in imagining the societal culture in its dynamics. The research sample consists of 727 students in business and engineering on undergraduate and graduate levels from Romania and Slovenia. The reaso...

LHCb's Time-Real Alignment in RunII

CERN Multimedia

Batozskaya, Varvara

2015-01-01

LHCb has introduced a novel real-time detector alignment and calibration strategy for LHC Run 2. Data collected at the start of the fill will be processed in a few minutes and used to update the alignment, while the calibration constants will be evaluated for each run. This procedure will improve the quality of the online alignment. Critically, this new real-time alignment and calibration procedure allows identical constants to be used in the online and offline reconstruction, thus improving the correlation between triggered and offline selected events. This offers the opportunity to optimise the event selection in the trigger by applying stronger constraints. The required computing time constraints are met thanks to a new dedicated framework using the multi-core farm infrastructure for the trigger. The motivation for a real-time alignment and calibration of the LHCb detector is discussed from both the operational and physics performance points of view. Specific challenges of this novel configur...

Model-Based Exploration of Societal Aging in the Netherlands

NARCIS (Netherlands)

Pruyt, E.; Logtens, T.W.A.

2015-01-01

Mismanagement of societal aging is an important threat to health care, social security, and the economy of many nations. A System Dynamics simulation model related to societal aging in the Netherlands and its implications for the Dutch welfare system is used here to generate exploratory scenarios

Minimal-effort planning of active alignment processes for beam-shaping optics

Science.gov (United States)

Haag, Sebastian; Schranner, Matthias; Müller, Tobias; Zontar, Daniel; Schlette, Christian; Losch, Daniel; Brecher, Christian; Roßmann, Jürgen

2015-03-01

In science and industry, the alignment of beam-shaping optics is usually a manual procedure. Many industrial applications utilizing beam-shaping optical systems require more scalable production solutions and therefore effort has been invested in research regarding the automation of optics assembly. In previous works, the authors and other researchers have proven the feasibility of automated alignment of beam-shaping optics such as collimation lenses or homogenization optics. Nevertheless, the planning efforts as well as additional knowledge from the fields of automation and control required for such alignment processes are immense. This paper presents a novel approach of planning active alignment processes of beam-shaping optics with the focus of minimizing the planning efforts for active alignment. The approach utilizes optical simulation and the genetic programming paradigm from computer science for automatically extracting features from a simulated data basis with a high correlation coefficient regarding the individual degrees of freedom of alignment. The strategy is capable of finding active alignment strategies that can be executed by an automated assembly system. The paper presents a tool making the algorithm available to end-users and it discusses the results of planning the active alignment of the well-known assembly of a fast-axis collimator. The paper concludes with an outlook on the transferability to other use cases such as application specific intensity distributions which will benefit from reduced planning efforts.

Implementation of a Parallel Protein Structure Alignment Service on Cloud

Directory of Open Access Journals (Sweden)

Che-Lun Hung

2013-01-01

Full Text Available Protein structure alignment has become an important strategy by which to identify evolutionary relationships between protein sequences. Several alignment tools are currently available for online comparison of protein structures. In this paper, we propose a parallel protein structure alignment service based on the Hadoop distribution framework. This service includes a protein structure alignment algorithm, a refinement algorithm, and a MapReduce programming model. The refinement algorithm refines the result of alignment. To process vast numbers of protein structures in parallel, the alignment and refinement algorithms are implemented using MapReduce. We analyzed and compared the structure alignments produced by different methods using a dataset randomly selected from the PDB database. The experimental results verify that the proposed algorithm refines the resulting alignments more accurately than existing algorithms. Meanwhile, the computational performance of the proposed service is proportional to the number of processors used in our cloud platform.

Encouraging Spontaneous Synchronisation with D-Jogger, an Adaptive Music Player That Aligns Movement and Music

Science.gov (United States)

Moens, Bart; Muller, Chris; van Noorden, Leon; Franěk, Marek; Celie, Bert; Boone, Jan; Bourgois, Jan; Leman, Marc

2014-01-01

In this study we explore how music can entrain human walkers to synchronise to the musical beat without being instructed to do so. For this, we use an interactive music player, called D-Jogger, that senses the user's walking tempo and phase. D-Jogger aligns the music by manipulating the timing difference between beats and footfalls. Experiments are reported that led to the development and optimisation of four alignment strategies. The first strategy matched the music's tempo continuously to the runner's pace. The second strategy matched the music's tempo at the beginning of a song to the runner's pace, keeping the tempo constant for the remainder of the song. The third alignment starts a song in perfect phase synchrony and continues to adjust the tempo to match the runner's pace. The fourth and last strategy additionally adjusts the phase of the music so each beat matches a footfall. The first two strategies resulted in a minor increase of steps in phase synchrony with the main beat when compared to a random playlist, the last two strategies resulted in a strong increase in synchronised steps. These results may be explained in terms of phase-error correction mechanisms and motor prediction schemes. Finding the phase-lock is difficult due to fluctuations in the interaction, whereas strategies that automatically align the phase between movement and music solve the problem of finding the phase-locking. Moreover, the data show that once the phase-lock is found, alignment can be easily maintained, suggesting that less entrainment effort is needed to keep the phase-lock, than to find the phase-lock. The different alignment strategies of D-Jogger can be applied in different domains such as sports, physical rehabilitation and assistive technologies for movement performance. PMID:25489742

Societal costs of multiple sclerosis in Ireland.

Science.gov (United States)

Carney, Peter; O'Boyle, Derek; Larkin, Aidan; McGuigan, Christopher; O'Rourke, Killian

2018-05-01

This paper evaluates the impact of multiple sclerosis (MS) in Ireland, and estimates the associated direct, indirect, and intangible costs to society based on a large nationally representative sample. A questionnaire was developed to capture the demographics, disease characteristics, healthcare use, informal care, employment, and wellbeing. Referencing international studies, standardized survey instruments were included (e.g. CSRI, MFIS-5, EQ-5D) or adapted (EDSS) for inclusion in an online survey platform. Recruitment was directed at people with MS via the MS Society mailing list and social media platforms, as well as in traditional media. The economic costing was primarily conducted using a 'bottom-up' methodology, and national estimates were achieved using 'prevalence-based' extrapolation. A total of 594 people completed the survey in full. The sample had geographic, disease, and demographic characteristics indicating good representativeness. At an individual level, average societal cost was estimated at €47,683; the average annual costs for those with mild, moderate, and severe MS were calculated as €34,942, €57,857, and €100,554, respectively. For a total Irish MS population of 9,000, the total societal costs of MS amounted to €429m. Direct costs accounted for just 30% of the total societal costs, indirect costs amounted to 50% of the total, and intangible or QoL costs represented 20%. The societal cost associated with a relapse in the sample is estimated as €2,438. The findings highlight that up to 70% of the total costs associated with MS are not routinely counted. These "hidden" costs are higher in Ireland than the rest of Europe, due in part to significantly lower levels of workforce participation, a higher likelihood of permanent workforce withdrawal, and higher levels of informal care needs. The relationship between disease progression and costs emphasize the societal importance of managing and slowing the progression of the illness.

Automated whole-genome multiple alignment of rat, mouse, and human

Energy Technology Data Exchange (ETDEWEB)

Brudno, Michael; Poliakov, Alexander; Salamov, Asaf; Cooper, Gregory M.; Sidow, Arend; Rubin, Edward M.; Solovyev, Victor; Batzoglou, Serafim; Dubchak, Inna

2004-07-04

We have built a whole genome multiple alignment of the three currently available mammalian genomes using a fully automated pipeline which combines the local/global approach of the Berkeley Genome Pipeline and the LAGAN program. The strategy is based on progressive alignment, and consists of two main steps: (1) alignment of the mouse and rat genomes; and (2) alignment of human to either the mouse-rat alignments from step 1, or the remaining unaligned mouse and rat sequences. The resulting alignments demonstrate high sensitivity, with 87% of all human gene-coding areas aligned in both mouse and rat. The specificity is also high: <7% of the rat contigs are aligned to multiple places in human and 97% of all alignments with human sequence > 100kb agree with a three-way synteny map built independently using predicted exons in the three genomes. At the nucleotide level <1% of the rat nucleotides are mapped to multiple places in the human sequence in the alignment; and 96.5% of human nucleotides within all alignments agree with the synteny map. The alignments are publicly available online, with visualization through the novel Multi-VISTA browser that we also present.

libgapmis: extending short-read alignments.

Science.gov (United States)

Alachiotis, Nikolaos; Berger, Simon; Flouri, Tomáš; Pissis, Solon P; Stamatakis, Alexandros

2013-01-01

A wide variety of short-read alignment programmes have been published recently to tackle the problem of mapping millions of short reads to a reference genome, focusing on different aspects of the procedure such as time and memory efficiency, sensitivity, and accuracy. These tools allow for a small number of mismatches in the alignment; however, their ability to allow for gaps varies greatly, with many performing poorly or not allowing them at all. The seed-and-extend strategy is applied in most short-read alignment programmes. After aligning a substring of the reference sequence against the high-quality prefix of a short read--the seed--an important problem is to find the best possible alignment between a substring of the reference sequence succeeding and the remaining suffix of low quality of the read--extend. The fact that the reads are rather short and that the gap occurrence frequency observed in various studies is rather low suggest that aligning (parts of) those reads with a single gap is in fact desirable. In this article, we present libgapmis, a library for extending pairwise short-read alignments. Apart from the standard CPU version, it includes ultrafast SSE- and GPU-based implementations. libgapmis is based on an algorithm computing a modified version of the traditional dynamic-programming matrix for sequence alignment. Extensive experimental results demonstrate that the functions of the CPU version provided in this library accelerate the computations by a factor of 20 compared to other programmes. The analogous SSE- and GPU-based implementations accelerate the computations by a factor of 6 and 11, respectively, compared to the CPU version. The library also provides the user the flexibility to split the read into fragments, based on the observed gap occurrence frequency and the length of the read, thereby allowing for a variable, but bounded, number of gaps in the alignment. We present libgapmis, a library for extending pairwise short-read alignments. We

Taxonomic bias in biodiversity data and societal preferences.

Science.gov (United States)

Troudet, Julien; Grandcolas, Philippe; Blin, Amandine; Vignes-Lebbe, Régine; Legendre, Frédéric

2017-08-22

Studying and protecting each and every living species on Earth is a major challenge of the 21 st century. Yet, most species remain unknown or unstudied, while others attract most of the public, scientific and government attention. Although known to be detrimental, this taxonomic bias continues to be pervasive in the scientific literature, but is still poorly studied and understood. Here, we used 626 million occurrences from the Global Biodiversity Information Facility (GBIF), the biggest biodiversity data portal, to characterize the taxonomic bias in biodiversity data. We also investigated how societal preferences and taxonomic research relate to biodiversity data gathering. For each species belonging to 24 taxonomic classes, we used the number of publications from Web of Science and the number of web pages from Bing searches to approximate research activity and societal preferences. Our results show that societal preferences, rather than research activity, strongly correlate with taxonomic bias, which lead us to assert that scientists should advertise less charismatic species and develop societal initiatives (e.g. citizen science) that specifically target neglected organisms. Ensuring that biodiversity is representatively sampled while this is still possible is an urgent prerequisite for achieving efficient conservation plans and a global understanding of our surrounding environment.

Children’s proximal societal conditions

DEFF Research Database (Denmark)

Stanek, Anja Hvidtfeldt

or the children’s everyday life, but something that is represented through societal structures and actual persons participating (in political ways) within the institutional settings, in ways that has meaning to children’s possibilities to participate, learn and develop. Understanding school or daycare as (part of......) the children’s proximal societal conditions for development and learning, means for instance that considerations about an inclusive agenda in a (Danish) welfare state with well-developed school- and daycare system, are no longer simply thoughts about the school having space for as many pupils as possible...... (schools for all). Such thoughts can or should be supplemented by reflections about which version of ‘the societal’ we wish to present our children with, and which version of ‘the societal’ we wish to set up as the condition for children’s participation and development. These questions require an ethical...

Modeled effects of an improved building insulation scenario in Europe on air pollution, health and societal costs

DEFF Research Database (Denmark)

Bønløkke, Jakob Hjort; Holst, Gitte Juel; Sigsgaard, Torben

2015-01-01

scenario in Europe would have substantial benefits on health through improvements in air pollution. Health effects and societal cost savings may significantly counterbalance investment costs and should be taken into account when evaluating strategies for mitigation of global warming....... with extensions. Mean annual changes in the main air pollutants were derived for each country. World Health Organization (WHO) and European Union (EU) data on populations and on impacts of pollutants were used to derive health effects and costs. Effects on indoor air quality were not assessed. Results: Projected...... 78678 LY in Europe. A total of 7173 cases of persistent chronic bronchitis could be avoided annually. Several other health outcomes improved similarly. The saved societal costs totaled 6.64 billion € annually. Conclusions: In addition to carbon emission reductions, an improved building insulation...

Societal Dynamics Understanding Social Knowledge and Wisdom

CERN Document Server

Betz, Frederick

2012-01-01

At both a micro-information level and a macro-societal level, the concepts of “knowledge” and “wisdom” are complementary – in both decisions and in social structures and institutions.  At the decision level, knowledge is concerned with how to make a proper choice of means, where “best” is measured as the efficiency toward achieving an end.  Wisdom is concerned with how to make a proper choice of ends  that attain “best” values. At a societal level, knowledge is managed through science/technology and innovation.  And while science/technology is society's way to create new means with high efficiencies, they reveal nothing about values.  Technology can be used for good or for evil, to make the world into a garden or to destroy all life.  It is societal wisdom which should influence the choice of proper ends -- ends to make the world a garden. How can society make progress in wisdom as well as knowledge?  Historically, the disciplines of the physical sciences and biology have provided sci...

Market Reform, Programmatic (DeAlignment and Party System Stability in Latin America

Directory of Open Access Journals (Sweden)

Kenneth M. ROBERTS

2013-07-01

Full Text Available Although democratic regimes in Latin America since the early 1980s have been surprisingly durable, party systems in much of the region continue to experience very high levels of electoral instability. A critical juncture approach to institutional change suggests that variation in party system stability is related to the impact of market liberalization in the 1980s and 90s on the programmatic alignment –or (dealignment– of partisan competition. Market reforms that were adopted by conservative leaders and opposed by a major leftist rival aligned party systems programmatically, allowing societal opposition to be channeled into institutionalized forms of competition that were highly stable in the post-adjustment era. By contrast, «bait-and-switch» reforms adopted by populist or leftist leaders were programmatically de-aligning for party systems, leaving them vulnerable to highly destabilizing reactive sequences in the aftermath to the reform process-including mass social protests, the demise of historic conservative parties, and the outflanking of traditional populist or leftist parties by more radical, anti-neoliberal outsiders. The political dynamics of market-based economic adjustment thus heavily conditioned the ways in which party systems would process the post-adjustment revival of populist and leftist alternatives in the region.

La Società Umanitaria e la diffusione del Metodo Montessori (1908-1923

Directory of Open Access Journals (Sweden)

Irene Pozzi

2015-07-01

Full Text Available The Società Umanitaria ofMilan, between 1918 and 1923, played an essential role in spreading and developing the Montessori Method. Studying in the Historical Archive of Società Umanitaria the numerous documents there collected, the author reconstructed the crucial moments of the extremely significant collaboration between Maria Montessori and Augusto Osimo, General Secretary of the Società Umanitaria.This complex and in-depth investigation was guided by the analysis, in specific, of the training courses for Montessori teachers organised by Società Umanitaria, essentially unexamined before this study, that allowed the researcher to have a deep insight into the action of Società Umanitaria aimed to promote and implement the Montessori Method in Italy and all around the world.

Business-IT alignment in PSS value networks : a capability-based framework

NARCIS (Netherlands)

Bagheri, S.; Kusters, R.J.; Trienekens, J.J.M.; Camarinha-Matos, L.M.; Afsarmanesh, H.

2014-01-01

Advanced information technology (IT) is regarded as a foundation for the operation of product-service system (PSS) value networks. This requires alignment between IT and PSS business strategy. Business‐IT alignment (BIA) in a value network can raise the ability of partners to collaborate effectively

Stimulating Strategically Aligned Behaviour Among Employees

NARCIS (Netherlands)

C.B.M. van Riel (Cees); G.A.J.M. Berens (Guido); M. Dijkstra (Majorie)

2007-01-01

textabstractIn recent years it has become increasingly important for companies to ensure strategically aligned behaviour, i.e., employee actions that are consistent with the company’s strategy. This study provides insights into the way companies can stimulate such behaviour through motivating and

Stimulating Strategically Aligned Behaviour among Employees

NARCIS (Netherlands)

C.B.M. van Riel (Cees); G.A.J.M. Berens (Guido); M. Dijkstra (Majorie)

2008-01-01

textabstractStrategically aligned behaviour (SAB), i.e., employee action that is consistent with the company’s strategy, is of vital importance to companies. This study provides insights into the way managers can promote such behaviour among employees by stimulating employee motivation and by

Technology Education and Societal Change.

Science.gov (United States)

Gilberti, Anthony F.

1994-01-01

Citizens in a democracy should understand the relationship of technological development to societal change. The rationale for universal technological education stems from the ideals of cultural education, the responsibilities of democratic life, and the need for economic security. Technology education furthers understanding of our technological…

Commissioning the CMS Alignment and Calibration Framework

CERN Document Server

Futyan, David

2009-01-01

The CMS experiment has developed a powerful framework to ensure the precise and prompt alignment and calibration of its components, which is a major prerequisite to achieve the optimal performance for physics analysis. The prompt alignment and calibration strategy harnesses computing resources both at the Tier-0 site and the CERN Analysis Facility (CAF) to ensure fast turnaround for updating the corresponding database payloads. An essential element is the creation of dedicated data streams concentrating the specific event information required by the various alignment and calibration workflows. The resulting low latency is required for feeding the resulting constants into the prompt reconstruction process, which is essential for achieving swift physics analysis of the LHC data. This report discusses the implementation and the computational aspects of the alignment and calibration framework. Recent commissioning campaigns with cosmic muons, beam halo and simulated data have been used to gain detailed experience...

Development of an Updated Societal-Risk Goal for Nuclear Power Safety

Energy Technology Data Exchange (ETDEWEB)

Vicki Bier; Michael Corradini; Robert Youngblood; Caleb Roh; Shuji Liu

2014-07-01

This report briefly summarizes work done in FY 2013 on the subject LDRD. The working hypothesis is that societal disruption should be addressed in a safety goal. This is motivated by the point that the Fukushima disaster resulted in very little public dose, but enormous societal disruption; a goal that addressed societal disruption would fill a perceived gap in the US NRC safety goal structure. This year's work entailed analyzing the consequences of postulated accidents at various reactor sites in the US, specifically with a view to quantifying the number of people relocated and the duration of their relocation, to see whether this makes sense as a measure of societal disruption.

Influencing governance of a public-private partnership in plant genomics: The societal interface group as a new instrument for public involvement

NARCIS (Netherlands)

Hanssen, L.; Gremmen, B.

2013-01-01

The Centre for BioSystems Genomics (CBSG) is a Dutch public-private partnership in plant genomics active in potato and tomato research and exploitation. Its Societal Interface Group (SIG) has been developed to inform its communication strategy and governance practice. This new instrument identifies

Strategy-aligned fuzzy approach for market segment evaluation and selection: a modular decision support system by dynamic network process (DNP)

Science.gov (United States)

Mohammadi Nasrabadi, Ali; Hosseinpour, Mohammad Hossein; Ebrahimnejad, Sadoullah

2013-05-01

In competitive markets, market segmentation is a critical point of business, and it can be used as a generic strategy. In each segment, strategies lead companies to their targets; thus, segment selection and the application of the appropriate strategies over time are very important to achieve successful business. This paper aims to model a strategy-aligned fuzzy approach to market segment evaluation and selection. A modular decision support system (DSS) is developed to select an optimum segment with its appropriate strategies. The suggested DSS has two main modules. The first one is SPACE matrix which indicates the risk of each segment. Also, it determines the long-term strategies. The second module finds the most preferred segment-strategies over time. Dynamic network process is applied to prioritize segment-strategies according to five competitive force factors. There is vagueness in pairwise comparisons, and this vagueness has been modeled using fuzzy concepts. To clarify, an example is illustrated by a case study in Iran's coffee market. The results show that success possibility of segments could be different, and choosing the best ones could help companies to be sure in developing their business. Moreover, changing the priority of strategies over time indicates the importance of long-term planning. This fact has been supported by a case study on strategic priority difference in short- and long-term consideration.

Knowledge as Public Property : The Societal Relevance of Scientific Research

NARCIS (Netherlands)

Bouter, Lex M

2008-01-01

Universities are funded by public means to a large extend. It’s reasonable to expect that society benefits from the results. For scientific research this means that it should at least have a potential societal impact. Universities and individual investigators must explicitly consider the societal

Risk management: Role of societal factors in major industrial accidents

International Nuclear Information System (INIS)

Hovden, J.; Rausand, M.; Sergeev, G.

1995-01-01

The paper discusses factors influencing the occurrence of major accidents in complex technological systems. Societal factors are identified as most significant in this context. Important types of societal factors are pin-pointed and discussed. The safety situation in the former Soviet Union and in today's Russian is described. The calamities at Chernobyl, Three Mile Island, and partly also Bhopal are discussed, and the role of societal factors identified. A main point of view is that it is not surprising that these catastrophes happened in the then existing conditions. What is surprising is that they did not happen earlier exclamation point

Influence of Information Technology on Organization Strategy

Directory of Open Access Journals (Sweden)

Sibanda Mabutho

2017-02-01

Full Text Available The exponential development of information technology has presented many opportunities to organizations; however, it has also presented several challenges. A key challenge is how do organizations effectively use information technology and incorporate it into their strategies to make full use of its capabilities as an enabler. The fast-changing nature of information technology has resulted in little empirical evidence on how it influences organization strategy. The Strategic Alignment Model was a popular model created to assist organizations to align their information technology and their business strategy; however, the growth of technology may have made this model irrelevant in this age. Therefore, organizations need to determine what factors drive this alignment. Using hermeneutic phenomenology, 12 in-depth interviews were conducted within IBM South Africa to determine real-life drivers that help create this alignment. The themes derived from the interview texts reveal that consumers are becoming more empowered; therefore, organizations need to be more flexible in their business models and strategies. Furthermore, the integration of cross-functional roles in the organization at the management level allow for improved alignment between information technology and strategy as better integrated roles bring a combination of these two elements.

A First Look at Gender Inequality as a Societal Risk Factor for Dating Violence.

Science.gov (United States)

Gressard, Lindsay A; Swahn, Monica H; Tharp, Andra Teten

2015-09-01

One of ten U.S. high school students is a victim of adolescent dating violence (ADV). Understanding ADV risk factors guides prevention efforts; however, research examining community- and societal-level risk factors is scant. Societal gender inequality is a known risk factor for violence against women, but has yet to be explored in relation to ADV. This study aims to determine whether the Gender Inequality Index (GII) correlates with levels of physical and sexual ADV victimization across U.S. states. State-representative prevalence rates of self-reported physical and sexual ADV victimization were obtained from the 2013 Youth Risk Behavior Survey. The state GII includes five indicators: (1) maternal mortality; (2) adolescent birth rate; (3) government representation; (4) educational attainment; and (5) labor force participation. Pearson correlation coefficients determined the association between physical and sexual ADV victimization, the GII, and GII indicators. Analyses were conducted in August 2014. Among U.S. states, the prevalence of physical ADV victimization in 2013 ranged from 7.0% to 14.8%, and the prevalence of sexual ADV victimization ranged from 7.8% to 13.8%. The GII was significantly associated with the state prevalence of female physical ADV victimization (r=0.48, pgender inequality may be a societal-level risk factor for female physical ADV victimization. As ADV prevention strategies are implemented at the state level, further research examining the effect of gender inequality on ADV is needed. Published by Elsevier Inc.

Calibration and alignment of the CMS silicon tracking detector

International Nuclear Information System (INIS)

Stoye, M.

2007-07-01

The Large Hadron Collider (LHC) will dominate the high energy physics program in the coming decade. The discovery of the standard model Higgs boson and the discovery of super-symmetric particles are within the reach at the energy scale explored by the LHC. However, the high luminosity and the high energy of the colliding protons lead to challenging demands on the detectors. The hostile radiation environment requires irradiation hard detectors, where the innermost subdetectors, consisting of silicon modules, are most affected. This thesis is devoted to the calibration and alignment of the silicon tracking detector. Electron test beam data, taken at DESY, have been used to investigate the performance of detector modules which previously were irradiated with protons up to a dose expected after 10 years of operation. The irradiated sensors turned out to be still better than required. The performance of the inner tracking systems will be dominated by the degree to which the positions of the sensors can be determined. Only a track based alignment procedure can reach the required precision. Such an alignment procedure is a major challenge given that about 50000 geometry constants need to be measured. Making use of the novel χ 2 minimization program Millepede II an alignment strategy has been developed in which all detector components are aligned simultaneously, as many sources of information as possible are used, and all correlations between the position parameters of the detectors are taken into account. Utilizing simulated data, a proof of concept of the alignment strategy is shown. (orig.)

Calibration and alignment of the CMS silicon tracking detector

Energy Technology Data Exchange (ETDEWEB)

Stoye, M.

2007-07-15

The Large Hadron Collider (LHC) will dominate the high energy physics program in the coming decade. The discovery of the standard model Higgs boson and the discovery of super-symmetric particles are within the reach at the energy scale explored by the LHC. However, the high luminosity and the high energy of the colliding protons lead to challenging demands on the detectors. The hostile radiation environment requires irradiation hard detectors, where the innermost subdetectors, consisting of silicon modules, are most affected. This thesis is devoted to the calibration and alignment of the silicon tracking detector. Electron test beam data, taken at DESY, have been used to investigate the performance of detector modules which previously were irradiated with protons up to a dose expected after 10 years of operation. The irradiated sensors turned out to be still better than required. The performance of the inner tracking systems will be dominated by the degree to which the positions of the sensors can be determined. Only a track based alignment procedure can reach the required precision. Such an alignment procedure is a major challenge given that about 50000 geometry constants need to be measured. Making use of the novel {chi}{sup 2} minimization program Millepede II an alignment strategy has been developed in which all detector components are aligned simultaneously, as many sources of information as possible are used, and all correlations between the position parameters of the detectors are taken into account. Utilizing simulated data, a proof of concept of the alignment strategy is shown. (orig.)

Efficient strategy to Cu/Si catalyst into vertically aligned carbon ...

Indian Academy of Sciences (India)

Abstract. Bamboo-shaped vertically aligned carbon nanotubes (bs-VACNTs) were fabricated on Cu/Si catalyst by ... on Si wafer material when compared to the other commer- ..... [3] Li H, Zhao N, He C, Shi C, Du X, Li J and Cui Q 2008 Mater.

Commissioning the CMS alignment and calibration framework

International Nuclear Information System (INIS)

Futyan, David

2010-01-01

The CMS experiment has developed a powerful framework to ensure the precise and prompt alignment and calibration of its components, which is a major prerequisite to achieve the optimal performance for physics analysis. The prompt alignment and calibration strategy harnesses computing resources both at the Tier-0 site and the CERN Analysis Facility (CAF) to ensure fast turnaround for updating the corresponding database payloads. An essential element is the creation of dedicated data streams concentrating the specific event information required by the various alignment and calibration workflows. The resulting low latency is required for feeding the resulting constants into the prompt reconstruction process, which is essential for achieving swift physics analysis of the LHC data. This report discusses the implementation and the computational aspects of the alignment and calibration framework. Recent commissioning campaigns with cosmic muons, beam halo and simulated data have been used to gain detailed experience with this framework, and results of this validation are reported.

Alignment Challenges for a Future Linear Collider

CERN Document Server

Durand, H; Stern, G

2013-01-01

The preservation of ultra-low emittances in the main linac and Beam Delivery System area is one of the main challenges for linear colliders. This requires alignment tolerances never achieved before at that scale, down to the micrometre level. As a matter of fact, in the LHC, the goal for the smoothing of the components was to obtain a 1σ deviation with respect to a smooth curve of 0.15 mm over a 150 m long sliding window, while for the CLIC project for example, it corresponds to 10 μm over a sliding window of 200 m in the Beam Delivery System area. Two complementary strategies are being studied to fulfil these requirements: the development and validation of long range alignment systems over a few hundreds of metres and short range alignment systems over a few metres. The studies undertaken, with associated tests setups and the latest results will be detailed, as well as their application for the alignment of both CLIC and ILC colliders.

Societal costs and burden of otitis media in Portugal

Directory of Open Access Journals (Sweden)

Speets AM

2011-04-01

Full Text Available Anouk Speets1, Judith Wolleswinkel1, Cristina Cardoso21Pallas health research and consultancy, Rotterdam, the Netherlands; 2GlaxoSmithKline, Algés, PortugalAbstract: This study aimed to estimate the resource consumption and societal impact of otitis media (OM in children younger than five years of age in Portugal. An Internet survey on generic childhood symptoms and diseases was administered to a sample of parents. This self-report survey had been previously implemented in other European countries. Medically confirmed OM was defined as symptoms of earache or “running ear” and/or a diagnosis of OM provided by a medical doctor. Direct medical, nonmedical, and indirect nonmedical costs were calculated for individual cases. Mean total costs per OM episode were estimated at €334. This corresponds to an estimated societal impact of 72 million €/year, of which 39% were indirect nonmedical costs. An epidemiological study should help to confirm the results of this study, and evaluate whether an intervention to reduce the occurrence and/or duration of OM may have an impact on societal costs and quality of life for affected families.Keywords: otitis media, costs, societal burden, Portugal

Factors influencing societal response of nanotechnology: an expert stakeholder analysis

International Nuclear Information System (INIS)

Gupta, Nidhi; Fischer, Arnout R. H.; Lans, Ivo A. van der; Frewer, Lynn J.

2012-01-01

Nanotechnology can be described as an emerging technology and, as has been the case with other emerging technologies such as genetic modification, different socio-psychological factors will potentially influence societal responses to its development and application. These factors will play an important role in how nanotechnology is developed and commercialised. This article aims to identify expert opinion on factors influencing societal response to applications of nanotechnology. Structured interviews with experts on nanotechnology from North West Europe were conducted using repertory grid methodology in conjunction with generalized Procrustes analysis to examine the psychological constructs underlying societal uptake of 15 key applications of nanotechnology drawn from different areas (e.g. medicine, agriculture and environment, chemical, food, military, sports, and cosmetics). Based on expert judgement, the main factors influencing societal response to different applications of nanotechnology will be the extent to which applications are perceived to be beneficial, useful, and necessary, and how 'real' and physically close to the end-user these applications are perceived to be by the public.

Factors influencing societal response of nanotechnology: an expert stakeholder analysis

Science.gov (United States)

Gupta, Nidhi; Fischer, Arnout R. H.; van der Lans, Ivo A.; Frewer, Lynn J.

2012-05-01

Nanotechnology can be described as an emerging technology and, as has been the case with other emerging technologies such as genetic modification, different socio-psychological factors will potentially influence societal responses to its development and application. These factors will play an important role in how nanotechnology is developed and commercialised. This article aims to identify expert opinion on factors influencing societal response to applications of nanotechnology. Structured interviews with experts on nanotechnology from North West Europe were conducted using repertory grid methodology in conjunction with generalized Procrustes analysis to examine the psychological constructs underlying societal uptake of 15 key applications of nanotechnology drawn from different areas (e.g. medicine, agriculture and environment, chemical, food, military, sports, and cosmetics). Based on expert judgement, the main factors influencing societal response to different applications of nanotechnology will be the extent to which applications are perceived to be beneficial, useful, and necessary, and how 'real' and physically close to the end-user these applications are perceived to be by the public.

A paedophile scan to prevent child sexual abuse in child care? A thought experiment to problematize the notion of alignment in Responsible Research and Innovation.

Science.gov (United States)

de Jong, Irja Marije; Kupper, Frank; de Ruiter, Corine; Broerse, Jacqueline

2017-12-01

Responsible Research and Innovation (RRI) is a science policy concept that gained traction from 2000 onwards in the EU and US, in which alignment on purposes and values between different stakeholders is a key aspect. This thought experiment problematizes this particular notion: ethically acceptable and societally desirable outcomes are not necessarily achieved when alignment is a consequence of early closure. To argue this point, we took the example of the potential development of scanning technology for the detection of paedophilia among job applicants, for which indicators of broad societal support were found in an RRI project on neuroimaging. We analysed this case by looking through several lenses, obtained by structured and non-structured literature searches. We explored how facts and values are masked when a taboo topic is considered. This results in the black boxing of the problem definition, potential solutions and development trajectories. Complex unstructured problems can thus be perceived as manageable structured problems, which can in turn lead to irresponsible policies surrounding technology development. Responsible processes of research and technology development thus require the involvement of a critical reflector who is alert to signs of early closure and who prevents foreclosure of ongoing reflexive deliberation. There is an important role for ethical, legal and societal aspect studies within the framework of RRI. This paper shows that the concepts of "value/fact diversity masking" and "early discursive closure" are new avenues for RRI research.

Alignment of Short Reads: A Crucial Step for Application of Next-Generation Sequencing Data in Precision Medicine

Directory of Open Access Journals (Sweden)

Hao Ye

2015-11-01

Full Text Available Precision medicine or personalized medicine has been proposed as a modernized and promising medical strategy. Genetic variants of patients are the key information for implementation of precision medicine. Next-generation sequencing (NGS is an emerging technology for deciphering genetic variants. Alignment of raw reads to a reference genome is one of the key steps in NGS data analysis. Many algorithms have been developed for alignment of short read sequences since 2008. Users have to make a decision on which alignment algorithm to use in their studies. Selection of the right alignment algorithm determines not only the alignment algorithm but also the set of suitable parameters to be used by the algorithm. Understanding these algorithms helps in selecting the appropriate alignment algorithm for different applications in precision medicine. Here, we review current available algorithms and their major strategies such as seed-and-extend and q-gram filter. We also discuss the challenges in current alignment algorithms, including alignment in multiple repeated regions, long reads alignment and alignment facilitated with known genetic variants.

Capillary Self-Alignment of Microchips on Soft Substrates

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Bo Chang

2016-03-01

Full Text Available Soft micro devices and stretchable electronics have attracted great interest for their potential applications in sensory skins and wearable bio-integrated devices. One of the most important steps in building printed circuits is the alignment of assembled micro objects. Previously, the capillary self-alignment of microchips driven by surface tension effects has been shown to be able to achieve high-throughput and high-precision in the integration of micro parts on rigid hydrophilic/superhydrophobic patterned surfaces. In this paper, the self-alignment of microchips on a patterned soft and stretchable substrate, which consists of hydrophilic pads surrounded by a superhydrophobic polydimethylsiloxane (PDMS background, is demonstrated for the first time. A simple process has been developed for making superhydrophobic soft surface by replicating nanostructures of black silicon onto a PDMS surface. Different kinds of PDMS have been investigated, and the parameters for fabricating superhydrophobic PDMS have been optimized. A self-alignment strategy has been proposed that can result in reliable self-alignment on a soft PDMS substrate. Our results show that capillary self-alignment has great potential for building soft printed circuits.

Societal risk approach to safeguards design and evaluation

International Nuclear Information System (INIS)

Murphey, W.M.; Sherr, T.S.; Bennett, C.A.

1975-01-01

A comprehensive rationale for safeguards design and evaluation, and a framework for continuing systematic assessment of the system's effectiveness and efficient allocation of available safeguards resources for balanced protection, were developed. The societal risk approach employed considers the likelihood of successful destructive acts involving nuclear materials or facilities and the magnitude of the effects on society. The safeguards problem is described in terms of events affecting societal risk and adversary actions. Structure of the safeguards system and the evaluation of its adequacy are discussed. Adversary characteristics are also discussed

Societal Forces That ERODE Creativity

Science.gov (United States)

Sternberg, Robert; Kaufman, James C.

2018-01-01

Background/Context: Creativity is an indispensable force in intellectual, social, cultural, and economic development. Yet societal forces conspire to erode it. Educators have despaired for many years over how schools often fail to encourage creativity, but society as a whole is just as guilty. But how do schools and society fail to encourage, or…

The societal cost of Taenia solium cysticercosis in Tanzania

DEFF Research Database (Denmark)

Trevisan, Chiara; Devleesschauwer, Brecht; Schmidt, Veronika

2017-01-01

was to estimate the societal cost of T. solium cysticercosis in Tanzania, by assessing both the health and economic burden. The societal cost of T. solium cysticercosis was assessed in humans and pigs based on data obtained by a systematic review. Experts' opinion was sought in cases where data were...... losses due to porcine cysticercosis. Based on data retrieved from the systematic review and burden assessments, T. solium cysticercosis contributed to a significant societal cost for the population. The annual number of NCC-associated epilepsy incident cases and deaths were 17,853 (95% Uncertainty......Taenia solium is a zoonotic parasite prevalent in many low income countries throughout Latin America, Asia and sub-Saharan Africa, including Tanzania. The parasite is recognized as a public health threat; however the burden it poses on populations of Tanzania is unknown. The aim of this study...

Factors influencing societal response of nanotechnology: an expert stakeholder analysis

Energy Technology Data Exchange (ETDEWEB)

Gupta, Nidhi, E-mail: nidhi.gupta@wur.nl; Fischer, Arnout R. H., E-mail: arnout.fischer@wur.nl; Lans, Ivo A. van der, E-mail: Ivo.vanderLans@wur.nl [Wageningen University, Marketing and Consumer Behaviour Group (Netherlands); Frewer, Lynn J., E-mail: lynn.frewer@newcastle.ac.uk [Newcastle University, School of Agriculture, Food and Rural Development (United Kingdom)

2012-05-15

Nanotechnology can be described as an emerging technology and, as has been the case with other emerging technologies such as genetic modification, different socio-psychological factors will potentially influence societal responses to its development and application. These factors will play an important role in how nanotechnology is developed and commercialised. This article aims to identify expert opinion on factors influencing societal response to applications of nanotechnology. Structured interviews with experts on nanotechnology from North West Europe were conducted using repertory grid methodology in conjunction with generalized Procrustes analysis to examine the psychological constructs underlying societal uptake of 15 key applications of nanotechnology drawn from different areas (e.g. medicine, agriculture and environment, chemical, food, military, sports, and cosmetics). Based on expert judgement, the main factors influencing societal response to different applications of nanotechnology will be the extent to which applications are perceived to be beneficial, useful, and necessary, and how 'real' and physically close to the end-user these applications are perceived to be by the public.

Face Alignment Using Boosting and Evolutionary Search

NARCIS (Netherlands)

Zhang, Hua; Liu, Duanduan; Poel, Mannes; Nijholt, Antinus; Zha, H.; Taniguchi, R.-I.; Maybank, S.

2010-01-01

In this paper, we present a face alignment approach using granular features, boosting, and an evolutionary search algorithm. Active Appearance Models (AAM) integrate a shape-texture-combined morphable face model into an efficient fitting strategy, then Boosting Appearance Models (BAM) consider the

Ontology Alignment Repair through Modularization and Confidence-Based Heuristics.

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Emanuel Santos

Full Text Available Ontology Matching aims at identifying a set of semantic correspondences, called an alignment, between related ontologies. In recent years, there has been a growing interest in efficient and effective matching methods for large ontologies. However, alignments produced for large ontologies are often logically incoherent. It was only recently that the use of repair techniques to improve the coherence of ontology alignments began to be explored. This paper presents a novel modularization technique for ontology alignment repair which extracts fragments of the input ontologies that only contain the necessary classes and relations to resolve all detectable incoherences. The paper presents also an alignment repair algorithm that uses a global repair strategy to minimize both the degree of incoherence and the number of mappings removed from the alignment, while overcoming the scalability problem by employing the proposed modularization technique. Our evaluation shows that our modularization technique produces significantly small fragments of the ontologies and that our repair algorithm produces more complete alignments than other current alignment repair systems, while obtaining an equivalent degree of incoherence. Additionally, we also present a variant of our repair algorithm that makes use of the confidence values of the mappings to improve alignment repair. Our repair algorithm was implemented as part of AgreementMakerLight, a free and open-source ontology matching system.

Ontology Alignment Repair through Modularization and Confidence-Based Heuristics.

Science.gov (United States)

Santos, Emanuel; Faria, Daniel; Pesquita, Catia; Couto, Francisco M

2015-01-01

Ontology Matching aims at identifying a set of semantic correspondences, called an alignment, between related ontologies. In recent years, there has been a growing interest in efficient and effective matching methods for large ontologies. However, alignments produced for large ontologies are often logically incoherent. It was only recently that the use of repair techniques to improve the coherence of ontology alignments began to be explored. This paper presents a novel modularization technique for ontology alignment repair which extracts fragments of the input ontologies that only contain the necessary classes and relations to resolve all detectable incoherences. The paper presents also an alignment repair algorithm that uses a global repair strategy to minimize both the degree of incoherence and the number of mappings removed from the alignment, while overcoming the scalability problem by employing the proposed modularization technique. Our evaluation shows that our modularization technique produces significantly small fragments of the ontologies and that our repair algorithm produces more complete alignments than other current alignment repair systems, while obtaining an equivalent degree of incoherence. Additionally, we also present a variant of our repair algorithm that makes use of the confidence values of the mappings to improve alignment repair. Our repair algorithm was implemented as part of AgreementMakerLight, a free and open-source ontology matching system.

Experiences from the anatomy track in the ontology alignment evaluation initiative.

Science.gov (United States)

Dragisic, Zlatan; Ivanova, Valentina; Li, Huanyu; Lambrix, Patrick

2017-12-04

One of the longest running tracks in the Ontology Alignment Evaluation Initiative is the Anatomy track which focuses on aligning two anatomy ontologies. The Anatomy track was started in 2005. In 2005 and 2006 the task in this track was to align the Foundational Model of Anatomy and the OpenGalen Anatomy Model. Since 2007 the ontologies used in the track are the Adult Mouse Anatomy and a part of the NCI Thesaurus. Since 2015 the data in the Anatomy track is also used in the Interactive track of the Ontology Alignment Evaluation Initiative. In this paper we focus on the Anatomy track in the years 2007-2016 and the Anatomy part of the Interactive track in 2015-2016. We describe the data set and the changes it went through during the years as well as the challenges it poses for ontology alignment systems. Further, we give an overview of all systems that participated in the track and the techniques they have used. We discuss the performance results of the systems and summarize the general trends. About 50 systems have participated in the Anatomy track. Many different techniques were used. The most popular matching techniques are string-based strategies and structure-based techniques. Many systems also use auxiliary information. The quality of the alignment has increased for the best performing systems since the beginning of the track and more and more systems check the coherence of the proposed alignment and implement a repair strategy. Further, interacting with an oracle is beneficial.

The alignment of the ATLAS Inner Detector in Run 2

CERN Document Server

Ripellino, Giulia; The ATLAS collaboration

2016-01-01

The ATLAS reconstruction of charged particle trajectories relies on the Inner Detector tracking system. The accuracy of the reconstruction is limited by the finite resolution of the detector elements and the knowledge about their positions. A precise alignment of the detector is therefore essential. In this poster we present the strategy and the status of the Inner Detector alignment in ATLAS during the LHC Run 2.

Linking soil systems to societal value systems

Science.gov (United States)

Helming, Katharina; Daedlow, Katrin; Techen, Anja; Kaiser, David Brian

2017-04-01

Sustainable management of soils is needed to avoid soil degradation and to maintain soil functions. This requires the assessment of how human activities drive soil management, how soil management affect soil functions and soil degradation, which trade-offs occur and how they compromise sustainable development targets. In the frame of the German research programme "Soils as a sustainable resource for the bio-economy - BonaRes", we developed an enhanced approach of the DPSIR (driver-pressure-state-impact-response) cycle which helps to assess these interrelations. Because not all soil functions can be maximized simultaneously in space and time and trade-offs are inevitable, it depends on the societal value system to decide which management practices and respective soil functional performances are valued sustainably. We analysed the applicability of three valuation concepts being prominent in research about social-ecological systems, namely resource efficiency, ecosystem services, and ethics and equity. The concept of resource efficiency is based in the life-cycle thinking and is often applied at the level of the farming systems and in the context of bio-economy strategies. It covers the use of natural (water, energy, nutrients, land) and economic resources. At the landscape level, the concept of ecosystem services is prominent. Here, the contribution of soils to the provisioning, regulating and cultural services of the natural ecosystems is considered. Ethical considerations include the intrinsic values of nature as well as issues of local and global equity between different societal groups, generations, and localities. The three concepts cover different problem dimensions and complexity levels of soil management and decision making. Alone, none of them are capable to discover complex questions of sustainable soil management and development. Rather, the exact spatial and temporal framing of the sustainability problem at stake determines which combination of the value

AlignMe—a membrane protein sequence alignment web server

Science.gov (United States)

Stamm, Marcus; Staritzbichler, René; Khafizov, Kamil; Forrest, Lucy R.

2014-01-01

We present a web server for pair-wise alignment of membrane protein sequences, using the program AlignMe. The server makes available two operational modes of AlignMe: (i) sequence to sequence alignment, taking two sequences in fasta format as input, combining information about each sequence from multiple sources and producing a pair-wise alignment (PW mode); and (ii) alignment of two multiple sequence alignments to create family-averaged hydropathy profile alignments (HP mode). For the PW sequence alignment mode, four different optimized parameter sets are provided, each suited to pairs of sequences with a specific similarity level. These settings utilize different types of inputs: (position-specific) substitution matrices, secondary structure predictions and transmembrane propensities from transmembrane predictions or hydrophobicity scales. In the second (HP) mode, each input multiple sequence alignment is converted into a hydrophobicity profile averaged over the provided set of sequence homologs; the two profiles are then aligned. The HP mode enables qualitative comparison of transmembrane topologies (and therefore potentially of 3D folds) of two membrane proteins, which can be useful if the proteins have low sequence similarity. In summary, the AlignMe web server provides user-friendly access to a set of tools for analysis and comparison of membrane protein sequences. Access is available at http://www.bioinfo.mpg.de/AlignMe PMID:24753425

SOCIETAL CULTURE: A COMPARISON OF ROMANIAN, AUSTRIAN AND GERMAN STUDENTS PERSPECTIVE

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CATANA DOINA

2012-07-01

Full Text Available Our study compares the students’ view on the existing cultural practices with their ideal societal value system in compared societies. For the purpose of this investigation, Austria and Germany were selected to represent Central European values since they are seen as a ‘bridge’ between Eastern and Western European societal values. The research findings are helpful in identifying signs of cultural convergence of Romanian societal culture with Central European values. In doing so, our study will hopefully broaden the body of knowledge about the cultural harmonization between newer and older members of European Union. As seen in the literature review section, such studies started only a few years ago. Comparison of Romanian, Austrian and German students’ perspective on societal culture is performed for the first time by the authors of this study. \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\r\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\

Traditional acupuncturists and higher education in Britain: the dual, paradoxical impact of biomedical alignment on the holistic view.

Science.gov (United States)

Givati, Assaf; Hatton, Kieron

2015-04-01

Traditional acupuncturists' quest for external legitimacy in Britain involves the standardization of their knowledge bases through the development of training schools and syllabi, formal educational structures, and, since the 1990s, the teaching of undergraduate courses within (or validated by) Higher Education Institutions (HEIs), a process which entails biomedical alignment of the curriculum. However, as holistic discourses were commonly used as a rhetorical strategy by CAM practitioners to distance themselves from biomedicine and as a source of public appeal, this 'mainstreaming' process evoked practitioners' concerns that their holistic claims are being compromised. An additional challenge is being posed by a group of academics and scientists in Britain who launched an attack on CAM courses taught in HEIs, accusing them of being 'unscientific' and 'non-academic' in nature. This paper explores the negotiation of all these challenges during the formalization of traditional acupuncture education in Britain, with a particular focus on the role of HEIs. The in-depth qualitative investigation draws on several data sets: participant observation in a university validated acupuncture course; in-depth interviews; and documentary analysis. The findings show how, as part of the formalization process, acupuncturists in Britain (re)negotiate their holistic, anti-reductionist discourses and claims in relation to contemporary societal, political and cultural forces. Moreover, the teaching and validation of acupuncture courses by HEIs may contribute to broadening acupuncturists' 'holistic awareness' of societal and cultural influences on individuals' and communities' ill-health. This investigation emphasises the dynamic and context-specific (rather than fixed and essentialized) nature of acupuncture practice and knowledge. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Societal and Economic Value of Rotator Cuff Repair

Science.gov (United States)

Mather, Richard C.; Koenig, Lane; Acevedo, Daniel; Dall, Timothy M.; Gallo, Paul; Romeo, Anthony; Tongue, John; Williams, Gerald

2013-01-01

Background: Although rotator cuff disease is a common musculoskeletal problem in the United States, the impact of this condition on earnings, missed workdays, and disability payments is largely unknown. This study examines the value of surgical treatment for full-thickness rotator cuff tears from a societal perspective. Methods: A Markov decision model was constructed to estimate lifetime direct and indirect costs associated with surgical and continued nonoperative treatment for symptomatic full-thickness rotator cuff tears. All patients were assumed to have been unresponsive to one six-week trial of nonoperative treatment prior to entering the model. Model assumptions were obtained from the literature and data analysis. We obtained estimates of indirect costs using national survey data and patient-reported outcomes. Four indirect costs were modeled: probability of employment, household income, missed workdays, and disability payments. Direct cost estimates were based on average Medicare reimbursements with adjustments to an all-payer population. Effectiveness was expressed in quality-adjusted life years (QALYs). Results: The age-weighted mean total societal savings from rotator cuff repair compared with nonoperative treatment was $13,771 over a patient’s lifetime. Savings ranged from $77,662 for patients who are thirty to thirty-nine years old to a net cost to society of $11,997 for those who are seventy to seventy-nine years old. In addition, surgical treatment results in an average improvement of 0.62 QALY. Societal savings were highly sensitive to age, with savings being positive at the age of sixty-one years and younger. The estimated lifetime societal savings of the approximately 250,000 rotator cuff repairs performed in the U.S. each year was $3.44 billion. Conclusions: Rotator cuff repair for full-thickness tears produces net societal cost savings for patients under the age of sixty-one years and greater QALYs for all patients. Rotator cuff repair is cost

Alignment 2.0: Strategic use of new internet technologies in government

NARCIS (Netherlands)

Meijer, A.J.; Thaens, M.

2010-01-01

This paper challenges the view that strategies for using Web 2.0 should primarily be based upon technological characteristics. The value of the organizational strategic alignment approach for developing specific operational Web 2.0 strategies for government organizations is explored both

Understanding Societal Impact in Research and Technology Organisations using Productive Interactions

NARCIS (Netherlands)

van Dorp, Aad; Löwik, Sandor; de Weerd-Nederhof, Petra

2017-01-01

Research organisations receiving at least partly public funding are increasingly required to show their societal impact. Assessing societal impact is a complex task, because it involves very different aspects, is prone to bias from the assessor and even may be contradictory. Using the process and

Aligning innovation with grand societal challenges

DEFF Research Database (Denmark)

Ricard, Lykke Margot

2016-01-01

This paper investigates the European Technology Platforms (ETPs) in wind power and in CO2 capture and storage supported by the European Commission (EC). It examines the role of these Platforms in shaping the trajectory of European energy technology policy, and shows that the EC’s support for the ......This paper investigates the European Technology Platforms (ETPs) in wind power and in CO2 capture and storage supported by the European Commission (EC). It examines the role of these Platforms in shaping the trajectory of European energy technology policy, and shows that the EC’s support...... for the ETPs marks a change from a solely evidence-based policy approach to the use of bottom-up policies designed to mobilize human capital based on social actors’ expectations, uncertainties and visions. These two ETPs include hitherto missing ‘key players’ who can enhance commercial legitimacy on both...... a valuable first qualitative analysis of this phenomenon which is emerging as a new policy instrument....

A cross-national exploration of societal-level factors associated with child physical abuse and neglect.

Science.gov (United States)

Klevens, Joanne; Ports, Katie A; Austin, Chelsea; Ludlow, Ivan J; Hurd, Jacqueline

2017-11-28

Children around the world experience violence at the hands of their caregivers at alarming rates. A recent review estimates that a minimum of 50% of children in Asia, Africa, and North America experienced severe physical violence by caregivers in the past year, with large variations between countries. Identifying modifiable country-level factors driving these geographic variations has great potential for achieving population-level reductions in rates of child maltreatment. This study builds on previous research by focusing on caregiver-reported physical abuse and neglect victimisation, examining 22 societal factors representing 11 different constructs among 42 countries from 5 continents at different stages of development. Our findings suggest that gender inequity may be important for both child physical abuse and neglect. Indicators of literacy and development may also be important for child neglect. Given the limitations of the correlational findings and measurement issues, it is critical to continue to investigate societal-level factors of child maltreatment so that interventions and prevention efforts can incorporate strategies that have the greatest potential for population-level impact.

GraphAlignment: Bayesian pairwise alignment of biological networks

Directory of Open Access Journals (Sweden)

Kolář Michal

2012-11-01

Full Text Available Abstract Background With increased experimental availability and accuracy of bio-molecular networks, tools for their comparative and evolutionary analysis are needed. A key component for such studies is the alignment of networks. Results We introduce the Bioconductor package GraphAlignment for pairwise alignment of bio-molecular networks. The alignment incorporates information both from network vertices and network edges and is based on an explicit evolutionary model, allowing inference of all scoring parameters directly from empirical data. We compare the performance of our algorithm to an alternative algorithm, Græmlin 2.0. On simulated data, GraphAlignment outperforms Græmlin 2.0 in several benchmarks except for computational complexity. When there is little or no noise in the data, GraphAlignment is slower than Græmlin 2.0. It is faster than Græmlin 2.0 when processing noisy data containing spurious vertex associations. Its typical case complexity grows approximately as O(N2.6. On empirical bacterial protein-protein interaction networks (PIN and gene co-expression networks, GraphAlignment outperforms Græmlin 2.0 with respect to coverage and specificity, albeit by a small margin. On large eukaryotic PIN, Græmlin 2.0 outperforms GraphAlignment. Conclusions The GraphAlignment algorithm is robust to spurious vertex associations, correctly resolves paralogs, and shows very good performance in identification of homologous vertices defined by high vertex and/or interaction similarity. The simplicity and generality of GraphAlignment edge scoring makes the algorithm an appropriate choice for global alignment of networks.

Geological disposal of nuclear waste: II. From laboratory data to the safety analysis – Addressing societal concerns

International Nuclear Information System (INIS)

Grambow, Bernd; Bretesché, Sophie

2014-01-01

Highlights: • Models for repository safety can only partly be validated. • Long term risks need to be translated in the context of societal temporalities. • Social sciences need to be more strongly involved into safety assessment. - Abstract: After more than 30 years of international research and development, there is a broad technical consensus that geologic disposal of highly-radioactive waste will provide for the safety of humankind and the environment, now, and far into the future. Safety analyses have demonstrated that the risk, as measured by exposure to radiation, will be of little consequence. Still, there is not yet an operating geologic repository for highly-radioactive waste, and there remains substantial public concern about the long-term safety of geologic disposal. In these two linked papers, we argue for a stronger connection between the scientific data (paper I, Grambow et al., 2014) and the safety analysis, particularly in the context of societal expectations (paper II). In this paper (II), we assess the meaning of the technical results and derived models (paper I) for the determination of the long-term safety of a repository. We consider issues of model validity and their credibility in the context of a much broader historical, epistemological and societal context. Safety analysis is treated in its social and temporal dimensions. This perspective provides new insights into the societal dimension of scenarios and risk analysis. Surprisingly, there is certainly no direct link between increased scientific understanding and a public position for or against different strategies of nuclear waste disposal. This is not due to the public being poorly informed, but rather due to cultural cognition of expertise and historical and cultural perception of hazards to regions selected to host a geologic repository. The societal and cultural dimension does not diminish the role of science, as scientific results become even more important in distinguishing

Societal Aging in the Netherlands : Exploratory System Dynamics Modeling and Analysis

NARCIS (Netherlands)

Logtens, T.; Pruyt, E.; Gijsbers, G.W.

2012-01-01

Mismanagement of societal aging is an important threat to health care systems, social security systems, and the economy of many nations. a System Dynamics simulation model related to societal aging in the Netherlands and its implications for the Dutch welfare system is used here as a scenario

Theoretical and practical feasibility demonstration of a micrometric remotely controlled pre-alignment system for the CLIC linear collider

CERN Document Server

Mainaud Durand, H; Chritin, N; Griffet, S; Kemppinen, J; Sosin, M; Touze, T

2011-01-01

The active pre-alignment of the Compact Linear Collider (CLIC) is one of the key points of the project: the components must be pre-aligned w.r.t. a straight line within a few microns over a sliding window of 200 m, along the two linacs of 20 km each. The proposed solution consists of stretched wires of more than 200 m, overlapping over half of their length, which will be the reference of alignment. Wire Positioning Sensors (WPS), coupled to the supports to be pre-aligned, will perform precise and accurate measurements within a few microns w.r.t. these wires. A micrometric fiducialisation of the components and a micrometric alignment of the components on common supports will make the strategy of pre-alignment complete. In this paper, the global strategy of active pre-alignment is detailed and illustrated by the latest results demonstrating the feasibility of the proposed solution.

Insights into the concept of vitality: associations with participation and societal costs.

Science.gov (United States)

van Steenbergen, E; van Dongen, J M; Wendel-Vos, G C W; Hildebrandt, V H; Strijk, J E

2016-04-01

In healthcare, the focus is currently shifting from someone's disabilities to someone's abilities, which is also evident from the increasing focus on vitality. Vitality (here defined as energy, motivation and resilience) is an often used concept, which also aims at someone's capabilities. However, little is known about vitality yet; in particular about its association with participation and societal costs. Within a cross-sectional design, information regarding vitality, participation and societal costs was collected among 8015 Dutch adults aged 20 years and over. Vitality was measured using the validated Dutch Vitality Questionnaire (Vita-16). Information on economic (i.e. want/able to work, work absenteeism, work performance), societal (i.e. voluntary work, informal care giving) and social participation (i.e. quantity and quality of social contacts) and societal costs (i.e. healthcare and work-related costs) was collected using an internet survey. Significant associations were found between vitality and various economic (i.e.sustainable employability:want to work: β = 1.21, 95% CI: 0.99-1.43,able to work:β = 2.09, 95% CI: 1.79-2.38;work absenteeism: OR = 0.75, 95% CI: 0.71-0.79;work performance:β = 0.49, 95% CI: 0.46-0.52), societal (i.e.voluntary work, informal care) and social (i.e.quantity and quality of social contacts) participation measures, as well as between vitality and societal costs (i.e.healthcare costs:β = -213.73, 95% CI: €-311.13 to €-107.08),absenteeism costs: β = -338.57, 95% CI: €-465.36 to €-214.14 and presenteeism costs:β = -1293.31, 95% CI: €-1492.69 to €-1088.95). This study showed significant positive associations between vitality and economic, societal and social participation and negative associations between vitality and societal costs. This may stimulate research on interventions enhancing and maintaining vitality and thereby contributing to improved participation and reduced costs. © The Author 2015. Published by

Genomic multiple sequence alignments: refinement using a genetic algorithm

Directory of Open Access Journals (Sweden)

Lefkowitz Elliot J

2005-08-01

Full Text Available Abstract Background Genomic sequence data cannot be fully appreciated in isolation. Comparative genomics – the practice of comparing genomic sequences from different species – plays an increasingly important role in understanding the genotypic differences between species that result in phenotypic differences as well as in revealing patterns of evolutionary relationships. One of the major challenges in comparative genomics is producing a high-quality alignment between two or more related genomic sequences. In recent years, a number of tools have been developed for aligning large genomic sequences. Most utilize heuristic strategies to identify a series of strong sequence similarities, which are then used as anchors to align the regions between the anchor points. The resulting alignment is globally correct, but in many cases is suboptimal locally. We describe a new program, GenAlignRefine, which improves the overall quality of global multiple alignments by using a genetic algorithm to improve local regions of alignment. Regions of low quality are identified, realigned using the program T-Coffee, and then refined using a genetic algorithm. Because a better COFFEE (Consistency based Objective Function For alignmEnt Evaluation score generally reflects greater alignment quality, the algorithm searches for an alignment that yields a better COFFEE score. To improve the intrinsic slowness of the genetic algorithm, GenAlignRefine was implemented as a parallel, cluster-based program. Results We tested the GenAlignRefine algorithm by running it on a Linux cluster to refine sequences from a simulation, as well as refine a multiple alignment of 15 Orthopoxvirus genomic sequences approximately 260,000 nucleotides in length that initially had been aligned by Multi-LAGAN. It took approximately 150 minutes for a 40-processor Linux cluster to optimize some 200 fuzzy (poorly aligned regions of the orthopoxvirus alignment. Overall sequence identity increased only

Installation and alignment of the DAΦNE accelerators

International Nuclear Information System (INIS)

Biscari, C.; Sgamma, F.

1998-01-01

Installation, alignment and survey of the magnetic elements and vacuum chambers of DAΦNE are described. The networks of the Damping Ring and two Main Rings are described, focusing the techniques chosen to obtain the required precision. A description of the mechanical measurements, coupled to the magnetic ones, to refer the magnetic axis of quadrupoles and sextupoles to their fiducial is underlined: emPHIasis is put on the strategy to couple precision with quickness. The results of first PHIase alignment job and its refinement are analyzed using the orbit measurement

A rank-based sequence aligner with applications in phylogenetic analysis.

Directory of Open Access Journals (Sweden)

Liviu P Dinu

Full Text Available Recent tools for aligning short DNA reads have been designed to optimize the trade-off between correctness and speed. This paper introduces a method for assigning a set of short DNA reads to a reference genome, under Local Rank Distance (LRD. The rank-based aligner proposed in this work aims to improve correctness over speed. However, some indexing strategies to speed up the aligner are also investigated. The LRD aligner is improved in terms of speed by storing [Formula: see text]-mer positions in a hash table for each read. Another improvement, that produces an approximate LRD aligner, is to consider only the positions in the reference that are likely to represent a good positional match of the read. The proposed aligner is evaluated and compared to other state of the art alignment tools in several experiments. A set of experiments are conducted to determine the precision and the recall of the proposed aligner, in the presence of contaminated reads. In another set of experiments, the proposed aligner is used to find the order, the family, or the species of a new (or unknown organism, given only a set of short Next-Generation Sequencing DNA reads. The empirical results show that the aligner proposed in this work is highly accurate from a biological point of view. Compared to the other evaluated tools, the LRD aligner has the important advantage of being very accurate even for a very low base coverage. Thus, the LRD aligner can be considered as a good alternative to standard alignment tools, especially when the accuracy of the aligner is of high importance. Source code and UNIX binaries of the aligner are freely available for future development and use at http://lrd.herokuapp.com/aligners. The software is implemented in C++ and Java, being supported on UNIX and MS Windows.

Construct Validity of the Societal Outreach Scale (SOS).

Science.gov (United States)

Fike, David S; Denton, Jason; Walk, Matt; Kish, Jennifer; Gorman, Ira

2018-04-01

The American Physical Therapy Association (APTA) has been working toward a vision of increasing professional focus on societal-level health. However, performance of social responsibility and related behaviors by physical therapists remain relatively poorly integrated into practice. Promoting a focus on societal outreach is necessary for all health care professionals to impact the health of their communities. The objective was to document the validity of the 14-item Societal Outreach Scale (SOS) for use with practicing physical therapists. This study used a cross-sectional survey. The SOS was transmitted via email to all therapists who were licensed and practicing in 10 states in the United States that were purposefully selected to assure a broad representation. A sample of 2612 usable responses was received. Factor analysis was applied to assess construct validity of the instrument. Of alternate models, a 3-factor model best demonstrated goodness of fit with the sample data according to conventional indices (standardized root mean squared residual = .03, comparative fit index .96, root mean square error of approximation = .06). The 3 factors measured by the SOS were labeled Societal-Level Health Advocacy, Community Engagement/Social Integration, and Political Engagement. Internal consistency reliability was 0.7 for all factors. The 3-factor SOS demonstrated acceptable validity and reliability. Though the sample included a broad representation of physical therapists, this was a single cross-sectional study. Additional confirmatory factor analysis, reliability testing, and word refinement of the tool are warranted. Given the construct validity and reliability of the 3-factor SOS, it is recommended for use as a validated instrument to measure physical therapists' performance of social responsibility and related behaviors.

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G.Gomez.

Since June of 2009, the muon alignment group has focused on providing new alignment constants and on finalizing the hardware alignment reconstruction. Alignment constants for DTs and CSCs were provided for CRAFT09 data reprocessing. For DT chambers, the track-based alignment was repeated using CRAFT09 cosmic ray muons and validated using segment extrapolation and split cosmic tools. One difference with respect to the previous alignment is that only five degrees of freedom were aligned, leaving the rotation around the local x-axis to be better determined by the hardware system. Similarly, DT chambers poorly aligned by tracks (due to limited statistics) were aligned by a combination of photogrammetry and hardware-based alignment. For the CSC chambers, the hardware system provided alignment in global z and rotations about local x. Entire muon endcap rings were further corrected in the transverse plane (global x and y) by the track-based alignment. Single chamber track-based alignment suffers from poor statistic...

International Conference on Informatics and Communication Technologies for Societal Developmen

CERN Document Server

Bhojan, Anand; Peter, J

2015-01-01

This volume comprises research papers presented at the International Conference on Informatics and Communication Technologies for Societal Development (ICICTS 2014) held at Karunya University, India. The content focuses on the recent advancements in image or signal processing, computer vision, communication technologies, soft computing, advanced computing, data mining, and knowledge discovery. The primary objective of this volume is to facilitate advancement and application of the knowledge and to promote ideas that solve problems faced by society through cutting-edge technologies. The chapters contain selected articles from academicians, researchers, and industry experts in the form of frameworks, models, and architectures. Practical approaches, observations, and results of research that promotes societal development are also incorporated. This volume will serve as a useful compendium for interested readers and researchers working towards societal development from the technological perspective.

The Lisbon Strategy and the alignment of economic and social concerns

DEFF Research Database (Denmark)

Triantafillou, Peter; Hansen, Magnus

2011-01-01

-development and employment is seen to go hand-in-hand with economic innovation and competitiveness. This alignment, which is expressed through the worshipping of the Nordic welfare model in general and the notion of flexicurity in particular, seems to have a strong depoliticizing effect....

Anti-profit beliefs: How people neglect the societal benefits of profit.

Science.gov (United States)

Bhattacharjee, Amit; Dana, Jason; Baron, Jonathan

2017-11-01

Profit-seeking firms are stereotypically depicted as immoral and harmful to society. At the same time, profit-driven enterprise has contributed immensely to human prosperity. Though scholars agree that profit can incentivize societally beneficial behaviors, people may neglect this possibility. In 7 studies, we show that people see business profit as necessarily in conflict with social good, a view we call anti-profit beliefs . Studies 1 and 2 demonstrate that U.S. participants hold anti-profit views of real U.S. firms and industries. Study 3 shows that hypothetical organizations are seen as doing more harm when they are labeled "for-profit" rather than "non-profit," while Study 4 shows that increasing harm to society is viewed as a strategy for increasing a hypothetical firm's long-run profitability. Studies 5-7 demonstrate that carefully prompting subjects to consider the long run incentives of profit can attenuate anti-profit beliefs, while prompting short run thinking does nothing relative to a control. Together, these results suggest that the default view of profits is zero-sum. While people readily grasp how profit can incentivize firms to engage in practices that harm others, they neglect how it can incentivize firms to engage in practices that benefit others. Accordingly, people's stereotypes of profit-seeking firms are excessively negative. Even in one of the most market-oriented societies in history, people doubt the contributions of profit-seeking industry to societal progress. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

SOAP2: an improved ultrafast tool for short read alignment

DEFF Research Database (Denmark)

Li, Ruiqiang; Yu, Chang; Li, Yingrui

2009-01-01

SUMMARY: SOAP2 is a significantly improved version of the short oligonucleotide alignment program that both reduces computer memory usage and increases alignment speed at an unprecedented rate. We used a Burrows Wheeler Transformation (BWT) compression index to substitute the seed strategy...... for indexing the reference sequence in the main memory. We tested it on the whole human genome and found that this new algorithm reduced memory usage from 14.7 to 5.4 GB and improved alignment speed by 20-30 times. SOAP2 is compatible with both single- and paired-end reads. Additionally, this tool now supports...... multiple text and compressed file formats. A consensus builder has also been developed for consensus assembly and SNP detection from alignment of short reads on a reference genome. AVAILABILITY: http://soap.genomics.org.cn....

A Global Network Alignment Method Using Discrete Particle Swarm Optimization.

Science.gov (United States)

Huang, Jiaxiang; Gong, Maoguo; Ma, Lijia

2016-10-19

Molecular interactions data increase exponentially with the advance of biotechnology. This makes it possible and necessary to comparatively analyse the different data at a network level. Global network alignment is an important network comparison approach to identify conserved subnetworks and get insight into evolutionary relationship across species. Network alignment which is analogous to subgraph isomorphism is known to be an NP-hard problem. In this paper, we introduce a novel heuristic Particle-Swarm-Optimization based Network Aligner (PSONA), which optimizes a weighted global alignment model considering both protein sequence similarity and interaction conservations. The particle statuses and status updating rules are redefined in a discrete form by using permutation. A seed-and-extend strategy is employed to guide the searching for the superior alignment. The proposed initialization method "seeds" matches with high sequence similarity into the alignment, which guarantees the functional coherence of the mapping nodes. A greedy local search method is designed as the "extension" procedure to iteratively optimize the edge conservations. PSONA is compared with several state-of-art methods on ten network pairs combined by five species. The experimental results demonstrate that the proposed aligner can map the proteins with high functional coherence and can be used as a booster to effectively refine the well-studied aligners.

Understanding the Societal Impact of Humanities Scholarship

DEFF Research Database (Denmark)

Pedersen, David Budtz; Johansson, Lasse Gøhler

2016-01-01

in society. An important assumption in this paper is that impact should be studied both from conceptual, qualitative and quantitative perspectives. Any approach that focuses merely on scientific outputs (such as publications or citations) or that relies on purely bibliometric indicators will result...... both quantitative and qualitative tools, the paper argues that we need a better and more comprehensive understanding of the role the humanities as part of a wider web of societal institutions, networks, and agents. Granted that the impact of humanities breakthroughs cannot be located at clearly......The critical problem for understanding the societal impact of humanities scholarship is that we currently have no satisfactory tools for understanding how wider social impacts occur and, by implication, very few guidelines for stimulating a reflexive dialogue about the influence of the humanities...

Novel Real-time Calibration and Alignment Procedure for LHCb Run II

CERN Multimedia

Prouve, Claire

2016-01-01

In order to achieve optimal detector performance the LHCb experiment has introduced a novel real-time detector alignment and calibration strategy for Run II of the LHC. For the alignment tasks, data is collected and processed at the beginning of each fill while the calibrations are performed for each run. This real time alignment and calibration allows the same constants being used in both the online and offline reconstruction, thus improving the correlation between triggered and offline selected events. Additionally the newly computed alignment and calibration constants can be instantly used in the trigger, making it more efficient. The online alignment and calibration of the RICH detectors also enable the use of hadronic particle identification in the trigger. The computing time constraints are met through the use of a new dedicated framework using the multi-core farm infrastructure for the LHCb trigger. An overview of all alignment and calibration tasks is presented and their performance is shown.

Factors influencing societal response of nanotechnology : an expert stakeholder analysis

OpenAIRE

Gupta, N.; Fischer, A.R.H.; Lans, van der, I.A.; Frewer, L.J.

2012-01-01

Nanotechnology can be described as an emerging technology and, as has been the case with other emerging technologies such as genetic modification, different socio-psychological factors will potentially influence societal responses to its development and application. These factors will play an important role in how nanotechnology is developed and commercialised. This article aims to identify expert opinion on factors influencing societal response to applications of nanotechnology. Structured i...

Factors influencing societal response of nanotechnology: an expert stakeholder analysis

OpenAIRE

Gupta, Nidhi; Fischer, Arnout R. H.; van der Lans, Ivo A.; Frewer, Lynn J.

2012-01-01

Nanotechnology can be described as an emerging technology and, as has been the case with other emerging technologies such as genetic modification, different socio-psychological factors will potentially influence societal responses to its development and application. These factors will play an important role in how nanotechnology is developed and commercialised. This article aims to identify expert opinion on factors influencing societal response to applications of nanotechnology. Structured i...

Conspiracy theories as part of history : The role of societal crisis situations

NARCIS (Netherlands)

van Prooijen, Jan Willem; Douglas, Karen M.

2017-01-01

In the present contribution, we examine the link between societal crisis situations and belief in conspiracy theories. Contrary to common assumptions, belief in conspiracy theories has been prevalent throughout human history. We first illustrate historical incidents suggesting that societal crisis

Infrastructures and societal change. A view from the large technical systems field

NARCIS (Netherlands)

Vleuten, van der E.B.A.

2004-01-01

Infrastructural and societal changes intertwine in multiple ways. This makes the societal implications of infrastructural projects difficult to assess and anticipate. Yet in present day network societies this task is particularly urgent. This paper first identifies two positions that tend to

Formatt: Correcting protein multiple structural alignments by incorporating sequence alignment

Directory of Open Access Journals (Sweden)

Daniels Noah M

2012-10-01

Full Text Available Abstract Background The quality of multiple protein structure alignments are usually computed and assessed based on geometric functions of the coordinates of the backbone atoms from the protein chains. These purely geometric methods do not utilize directly protein sequence similarity, and in fact, determining the proper way to incorporate sequence similarity measures into the construction and assessment of protein multiple structure alignments has proved surprisingly difficult. Results We present Formatt, a multiple structure alignment based on the Matt purely geometric multiple structure alignment program, that also takes into account sequence similarity when constructing alignments. We show that Formatt outperforms Matt and other popular structure alignment programs on the popular HOMSTRAD benchmark. For the SABMark twilight zone benchmark set that captures more remote homology, Formatt and Matt outperform other programs; depending on choice of embedded sequence aligner, Formatt produces either better sequence and structural alignments with a smaller core size than Matt, or similarly sized alignments with better sequence similarity, for a small cost in average RMSD. Conclusions Considering sequence information as well as purely geometric information seems to improve quality of multiple structure alignments, though defining what constitutes the best alignment when sequence and structural measures would suggest different alignments remains a difficult open question.

The greening of black gold. Towards international environmental alignment in the petroleum industry

Energy Technology Data Exchange (ETDEWEB)

Van de Wateringen, S.L.

2005-06-24

The aim of this research is to expand the knowledge on the integration of environmental issues in the organisation and management of multinational corporations (MNCs). The present study analyses the characteristics and determining factors of the environmental strategy and the organisation of environmental management (structure) in the petroleum industry, driven by the following general question: (1) Which factors influence the relationship between environmental strategy and environmental structure in a multinational corporation? Sub-questions have been formulated to enable this analysis for the international petroleum industry: Q1: How can external contextual characteristics be classified in such a way that a relationship with environmental strategy and environmental structure can be studied?; Q2: How can internal characteristics of MNCs be characterised, in such a way that a relationship with environmental strategy and environmental structure can be studied?; and Q3: How can environmental strategy and structure of large MNCs be characterised, in such a way that influencing factors can be identified? To these ends, the research project has adjusted the strategic alignment model for environmental issues in MNCs. It is introduced as the 'International Environmental Alignment Framework'. As further discussed in Chapter 3, strategic alignment examines the cooperative and/or conflicting relationship between strategy and structure with the aim of improving efficiency and performance. Building on the concepts of strategic fit and functional integration, this model assumes that decisions need to be coordinated to achieve value. The International Environmental Alignment Framework copied the distinction between an internal, functional domain and an external, strategic domain. This allows for the inclusion of company, sector and country variables. Furthermore, the framework distinguishes three different orders of alignment (simple consistency, mutual reinforcement

Multi-path mapping for alignment strategies in emerging science and technologies

NARCIS (Netherlands)

Robinson, D.K.R.; Propp, T.; Propp, Tilo

2008-01-01

Roadmapping serves both short and long term (strategic) alignment in science and technology (S&T). Forecasts of the likely future development of S&T are generated; then research and development (R&D) efforts necessary to realize various goals are backcast. But for new and emerging S&T this trusted

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G.Gomez

2010-01-01

The main developments in muon alignment since March 2010 have been the production, approval and deployment of alignment constants for the ICHEP data reprocessing. In the barrel, a new geometry, combining information from both hardware and track-based alignment systems, has been developed for the first time. The hardware alignment provides an initial DT geometry, which is then anchored as a rigid solid, using the link alignment system, to a reference frame common to the tracker. The “GlobalPositionRecords” for both the Tracker and Muon systems are being used for the first time, and the initial tracker-muon relative positioning, based on the link alignment, yields good results within the photogrammetry uncertainties of the Tracker and alignment ring positions. For the first time, the optical and track-based alignments show good agreement between them; the optical alignment being refined by the track-based alignment. The resulting geometry is the most complete to date, aligning all 250 DTs, ...

How fair is safe enough? The cultural approach to societal technology choice

International Nuclear Information System (INIS)

Rayner, S.; Cantor, R.

1987-01-01

This paper consists of an argument and a pilot study. First is a general, perhaps philosophical, argument against the National Academy's viewpoint that dealing with risk is a two-stage process consisting of (a) assessment of facts, and (b) evaluation of facts in sociopolitical context. They argue that societal risk intrinsically revolves around social relations as much as around evaluations of probability. Second, they outline one particular approach to analyzing societal risk management styles. They call this the fairness hypothesis. Rather than focusing on probabilities and magnitudes of undesired events, this approach emphasizes societal preferences for principles of achieving consent to a technology, distributing liabilities, and investing trust in institutions. Conflict rather than probability is the chief focus of this approach to societal risk management. This view is illustrated by a recent empirical pilot study that explored the fairness hypothesis in the context of new nuclear technologies

Societal costs of diabetes mellitus in Denmark

DEFF Research Database (Denmark)

Sortsø, C; Green, A; Jensen, Peter Bjødstrup

2016-01-01

AIM: To provide comprehensive real-world evidence on societal diabetes-attributable costs in Denmark. METHODS: National register data are linked on an individual level through unique central personal registration numbers in Denmark. All patients in the Danish National Diabetes Register in 2011 (N...... = 318 729) were included in this study. Complication status was defined according to data from the Danish National Hospital Register. Diabetes-attributable costs were calculated as the difference between costs of patients with diabetes and the expected costs given the annual resource consumption...... of the diabetes-free population. RESULTS: Societal costs attributable to diabetes were estimated to be at least 4.27 billion EUR in 2011, corresponding to 14,349 EUR per patient-year. A twofold higher healthcare resource usage was found for patients with diabetes as compared with the diabetes-free population...

Differences between individual and societal health state valuations: any link with personality?

Science.gov (United States)

Chapman, Benjamin P; Franks, Peter; Duberstein, Paul R; Jerant, Anthony

2009-08-01

The concept of "adaptation" has been proposed to account for differences between individual and societal valuations of specific health states in patients with chronic diseases. Little is known about psychological indices of adaptational capacity, which may predict differences in individual and societal valuations of health states. We investigated whether such differences were partially explained by personality traits in chronic disease patients. Analysis of baseline data of randomized controlled trial. Three hundred seventy patients with chronic disease. The NEO-five factor inventory measure of personality, EuroQoL-5D (EQ-5D) societal-based, and the EQ visual analogue scale individually-based measures of health valuation. Regression analyses modeled Dev, a measure of difference between the EQ-Visual Analogue Scale and EQ-5D, as a function of personality traits, sociodemographic factors, and chronic diseases. Individual valuations were significantly and clinically higher than societal valuations among patients in the second and third quartile of conscientiousness (Dev = 0.08, P = 0.01); among covariates, only depression (Dev = -0.04, P = 0.046) was also associated with Dev. Compared with societal valuations of a given health state, persons at higher quartiles of conscientiousness report less disutility associated with poor health. The effect is roughly twice that of some estimates of minimally important clinical differences on the EQ-5D and of depression. Although useful at the aggregate level, societal preference measures may systematically undervalue the health states of more conscientious individuals. Future work should examine the impact this has on individual patient outcome evaluation in clinical studies.

Magnetic Alignment of Block Copolymer Microdomains by Intrinsic Chain Anisotropy.

Science.gov (United States)

Rokhlenko, Yekaterina; Gopinadhan, Manesh; Osuji, Chinedum O; Zhang, Kai; O'Hern, Corey S; Larson, Steven R; Gopalan, Padma; Majewski, Paweł W; Yager, Kevin G

2015-12-18

We examine the role of intrinsic chain susceptibility anisotropy in magnetic field directed self-assembly of a block copolymer using in situ x-ray scattering. Alignment of a lamellar mesophase is observed on cooling across the disorder-order transition with the resulting orientational order inversely proportional to the cooling rate. We discuss the origin of the susceptibility anisotropy, Δχ, that drives alignment and calculate its magnitude using coarse-grained molecular dynamics to sample conformations of surface-tethered chains, finding Δχ≈2×10^{-8}. From field-dependent scattering data, we estimate that grains of ≈1.2  μm are present during alignment. These results demonstrate that intrinsic anisotropy is sufficient to support strong field-induced mesophase alignment and suggest a versatile strategy for field control of orientational order in block copolymers.

Differential evolution-simulated annealing for multiple sequence alignment

Science.gov (United States)

Addawe, R. C.; Addawe, J. M.; Sueño, M. R. K.; Magadia, J. C.

2017-10-01

Multiple sequence alignments (MSA) are used in the analysis of molecular evolution and sequence structure relationships. In this paper, a hybrid algorithm, Differential Evolution - Simulated Annealing (DESA) is applied in optimizing multiple sequence alignments (MSAs) based on structural information, non-gaps percentage and totally conserved columns. DESA is a robust algorithm characterized by self-organization, mutation, crossover, and SA-like selection scheme of the strategy parameters. Here, the MSA problem is treated as a multi-objective optimization problem of the hybrid evolutionary algorithm, DESA. Thus, we name the algorithm as DESA-MSA. Simulated sequences and alignments were generated to evaluate the accuracy and efficiency of DESA-MSA using different indel sizes, sequence lengths, deletion rates and insertion rates. The proposed hybrid algorithm obtained acceptable solutions particularly for the MSA problem evaluated based on the three objectives.

Influence of new societal factors on neovascular age-related macular degeneration outcomes.

Science.gov (United States)

Giocanti-Aurégan, Audrey; Chbat, Elige; Darugar, Adil; Morel, Christophe; Morin, Bruno; Conrath, John; Devin, François

2018-02-01

To assess the impact of unstudied societal factors for neovascular age-related macular degeneration (nAMD) on functional outcomes after anti-VEGFs. Charts of 94 nAMD patients treated in the Monticelli-Paradis Centre, Marseille, France, were reviewed. Phone interviews were conducted to assess societal factors, including transportation, living status, daily reading and social security scheme (SSS). Primary outcome was the impact of family support and disease burden on functional improvement in nAMD. Between baseline and month 24 (M24), 42.4% of the variability in best-corrected visual acuity (BCVA) was explained by the cumulative effect of the following societal factors: intermittent out-patient follow-up, marital status, daily reading, transportation type, commuting time. No isolated societal factor significantly correlated with ETDRS BCVA severity at M24. A trend to correlation was observed between the EDTRS score at M24 and the SSS (P = 0.076), economic burden (P = 0.075), time between diagnosis and treatment initiation (P = 0.070). A significant correlation was found for the disease burdensome on the patient (P = 0.034) and low vision rehabilitation (P = 0.014). Societal factors could influence functional outcomes in nAMD patients treated with anti-VEGFs. They could contribute to the healing process or sustain disease progression.

A psycho-societal perspective on neoliberal welfare services in Denmark

DEFF Research Database (Denmark)

Andersen, Linda Lundgaard

2016-01-01

This article introduces a psycho-societal approach to the micro-processes of Danish neoliberal welfare services, elaborating a learning and identity perspective. My many years of encounters with professionals in welfare services have illuminated how they display a strong identification with...... of neoliberal policies and practices has dominated the Danish welfare sector. By applying a psycho-societal conceptual approach - illustrated by an empirical example - I sketch out how identification, ambivalence and defence are significant features of welfare service professionals’ learning and practices...

The Globalization of Higher Education as a Societal and Cultural Security Problem

Science.gov (United States)

Samier, Eugenie A.

2015-01-01

In this article, I propose a theory of the globalization of higher education as societal and cultural security problems for many regions of the world. The first section examines the field of security studies for theoretical frameworks appropriate to critiquing globalized higher education, including critical human, societal and cultural security…

Allocentric and contra-aligned spatial representations of a town environment in blind people.

Science.gov (United States)

Chiesa, Silvia; Schmidt, Susanna; Tinti, Carla; Cornoldi, Cesare

2017-10-01

Evidence concerning the representation of space by blind individuals is still unclear, as sometimes blind people behave like sighted people do, while other times they present difficulties. A better understanding of blind people's difficulties, especially with reference to the strategies used to form the representation of the environment, may help to enhance knowledge of the consequences of the absence of vision. The present study examined the representation of the locations of landmarks of a real town by using pointing tasks that entailed either allocentric points of reference with mental rotations of different degrees, or contra-aligned representations. Results showed that, in general, people met difficulties when they had to point from a different perspective to aligned landmarks or from the original perspective to contra-aligned landmarks, but this difficulty was particularly evident for the blind. The examination of the strategies adopted to perform the tasks showed that only a small group of blind participants used a survey strategy and that this group had a better performance with respect to people who adopted route or verbal strategies. Implications for the comprehension of the consequences on spatial cognition of the absence of visual experience are discussed, focusing in particular on conceivable interventions. Copyright © 2017 Elsevier B.V. All rights reserved.

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G.Gomez

2010-01-01

Most of the work in muon alignment since December 2009 has focused on the geometry reconstruction from the optical systems and improvements in the internal alignment of the DT chambers. The barrel optical alignment system has progressively evolved from reconstruction of single active planes to super-planes (December 09) to a new, full barrel reconstruction. Initial validation studies comparing this full barrel alignment at 0T with photogrammetry provide promising results. In addition, the method has been applied to CRAFT09 data, and the resulting alignment at 3.8T yields residuals from tracks (extrapolated from the tracker) which look smooth, suggesting a good internal barrel alignment with a small overall offset with respect to the tracker. This is a significant improvement, which should allow the optical system to provide a start-up alignment for 2010. The end-cap optical alignment has made considerable progress in the analysis of transfer line data. The next set of alignment constants for CSCs will there...

Linking the Observation of Essential Variables to Societal Benefits

Science.gov (United States)

Sylak-Glassman, E.

2017-12-01

Different scientific communities have established sets of commonly agreed upon essential variables to help coordinate data collection in a variety of Earth observation areas. As an example, the World Meteorological Organization Global Climate Observing System has identified 50 Essential Climate Variables (ECVs), such as sea-surface temperature and carbon dioxide, which are required to monitoring the climate and detect and attribute climate change. In addition to supporting climate science, measuring these ECVs deliver many types of societal benefits, ranging from disaster mitigation to agricultural productivity to human health. While communicating the value in maintaining and improving observational records for these variables has been a challenge, quantifying how the measurement of these ECVs results in the delivery of many different societal benefits may help support their continued measurement. The 2016 National Earth Observation Assessment (EOA 2016) quantified the impact of individual Earth observation systems, sensors, networks, and surveys (or Earth observation systems, for short) on the achievement of 217 Federal objectives in 13 societal benefit areas (SBAs). This study will demonstrate the use of the EOA 2016 dataset to show the different Federal objectives and SBAs that are impacted by the Earth observation systems used to measure ECVs. Describing how the measurements from these Earth observation systems are used not only to maintain the climate record but also to meet additional Federal objectives may help articulate the continued measurement of the ECVs. This study will act as a pilot for the use of the EOA 2016 dataset to map between the measurements required to observe additional sets of variables, such as the Essential Ocean Variables and Essential Biodiversity Variables, and the ability to achieve a variety of societal benefits.

Organizational Alignment Supporting Distance Education in Post-Secondary Institutions.

Science.gov (United States)

Prestera, Gustavo E.; Moller, Leslie A.

2001-01-01

Applies an established model of organizational alignment to distance education in postsecondary institutions and recommends performance-oriented approaches to support growth by analyzing goals, structure, and management practices across the organization. Presents performance improvement strategies such as benchmarking and documenting workflows,…

The voice of the visual : visual learning strategies for problem analysis, social dialogue and mediated participation

NARCIS (Netherlands)

Witteveen, L.M.

2009-01-01

The changing needs for innovative learning strategies in the life sciences results from the growing complexity of societal issues. Nowadays, complex societal issues are also called ‘wicked problems.’ Wicked problems are problems that do not have one single solution that is right or wrong, good or

Long Read Alignment with Parallel MapReduce Cloud Platform

Science.gov (United States)

Al-Absi, Ahmed Abdulhakim; Kang, Dae-Ki

2015-01-01

Genomic sequence alignment is an important technique to decode genome sequences in bioinformatics. Next-Generation Sequencing technologies produce genomic data of longer reads. Cloud platforms are adopted to address the problems arising from storage and analysis of large genomic data. Existing genes sequencing tools for cloud platforms predominantly consider short read gene sequences and adopt the Hadoop MapReduce framework for computation. However, serial execution of map and reduce phases is a problem in such systems. Therefore, in this paper, we introduce Burrows-Wheeler Aligner's Smith-Waterman Alignment on Parallel MapReduce (BWASW-PMR) cloud platform for long sequence alignment. The proposed cloud platform adopts a widely accepted and accurate BWA-SW algorithm for long sequence alignment. A custom MapReduce platform is developed to overcome the drawbacks of the Hadoop framework. A parallel execution strategy of the MapReduce phases and optimization of Smith-Waterman algorithm are considered. Performance evaluation results exhibit an average speed-up of 6.7 considering BWASW-PMR compared with the state-of-the-art Bwasw-Cloud. An average reduction of 30% in the map phase makespan is reported across all experiments comparing BWASW-PMR with Bwasw-Cloud. Optimization of Smith-Waterman results in reducing the execution time by 91.8%. The experimental study proves the efficiency of BWASW-PMR for aligning long genomic sequences on cloud platforms. PMID:26839887

Sensing Characteristics of A Precision Aligner Using Moire Gratings for Precision Alignment System

Institute of Scientific and Technical Information of China (English)

ZHOU Lizhong; Hideo Furuhashi; Yoshiyuki Uchida

2001-01-01

Sensing characteristics of a precision aligner using moire gratings for precision alignment sysem has been investigated. A differential moire alignment system and a modified alignment system were used. The influence of the setting accuracy of the gap length and inclination of gratings on the alignment accuracy has been studied experimentally and theoretically. Setting accuracy of the gap length less than 2.5μm is required in modified moire alignment. There is no influence of the gap length on the alignment accuracy in the differential alignment system. The inclination affects alignment accuracies in both differential and modified moire alignment systems.

MUON DETECTORS: ALIGNMENT

CERN Multimedia

Z. Szillasi and G. Gomez.

2013-01-01

When CMS is opened up, major components of the Link and Barrel Alignment systems will be removed. This operation, besides allowing for maintenance of the detector underneath, is needed for making interventions that will reinforce the alignment measurements and make the operation of the alignment system more reliable. For that purpose and also for their general maintenance and recalibration, the alignment components will be transferred to the Alignment Lab situated in the ISR area. For the track-based alignment, attention is focused on the determination of systematic uncertainties, which have become dominant, since now there is a large statistics of muon tracks. This will allow for an improved Monte Carlo misalignment scenario and updated alignment position errors, crucial for high-momentum muon analysis such as Z′ searches.

Triangular Alignment (TAME). A Tensor-based Approach for Higher-order Network Alignment

Energy Technology Data Exchange (ETDEWEB)

Mohammadi, Shahin [Purdue Univ., West Lafayette, IN (United States); Gleich, David F. [Purdue Univ., West Lafayette, IN (United States); Kolda, Tamara G. [Sandia National Laboratories (SNL-CA), Livermore, CA (United States); Grama, Ananth [Purdue Univ., West Lafayette, IN (United States)

2015-11-01

Network alignment is an important tool with extensive applications in comparative interactomics. Traditional approaches aim to simultaneously maximize the number of conserved edges and the underlying similarity of aligned entities. We propose a novel formulation of the network alignment problem that extends topological similarity to higher-order structures and provide a new objective function that maximizes the number of aligned substructures. This objective function corresponds to an integer programming problem, which is NP-hard. Consequently, we approximate this objective function as a surrogate function whose maximization results in a tensor eigenvalue problem. Based on this formulation, we present an algorithm called Triangular AlignMEnt (TAME), which attempts to maximize the number of aligned triangles across networks. We focus on alignment of triangles because of their enrichment in complex networks; however, our formulation and resulting algorithms can be applied to general motifs. Using a case study on the NAPABench dataset, we show that TAME is capable of producing alignments with up to 99% accuracy in terms of aligned nodes. We further evaluate our method by aligning yeast and human interactomes. Our results indicate that TAME outperforms the state-of-art alignment methods both in terms of biological and topological quality of the alignments.

Active manipulation of the selective alignment by two laser pulses

International Nuclear Information System (INIS)

Zeng-Qiang, Yang; Zhi-Rong, Guo; Gui-Xian, Ge

2010-01-01

This paper solves numerically the full time-dependent Schrödinger equation based on the rigid rotor model, and proposes a novel strategy to determine the optimal time delay of the two laser pulses to manipulate the molecular selective alignment. The results illustrate that the molecular alignment generated by the first pulse can be suppressed or enhanced selectively, the relative populations of even and odd rotational states in the final rotational wave packet can be manipulated selectively by precisely inserting the peak of the second laser pulse at the time when the slope for the alignment parameter by the first laser locates a local maximum for the even rotational states and a local minimum for the odds, and vice versa. The selective alignment can be further optimised by selecting the intensity ratio of the two laser pulses on the condition that the total laser intensity and pulse duration are kept constant. (atomic and molecular physics)

A societal cost-of-illness study of hemodialysis in Lebanon.

Science.gov (United States)

Rizk, Rana; Hiligsmann, Mickaël; Karavetian, Mirey; Salameh, Pascale; Evers, Silvia M A A

2016-12-01

Renal failure is a growing public health problem, and is mainly treated by hemodialysis. This study aims to estimate the societal costs of hemodialysis in Lebanon. This was a quantitative, cross-sectional cost-of-illness study conducted alongside the Nutrition Education for Management of Osteodystrophy trial. Costs were assessed with a prevalence-based, bottom-up approach, for the period of June-December 2011. The data of 114 patients recruited from six hospital-based units were collected through a questionnaire measuring healthcare costs, costs to patients and family, and costs in other sectors. Recall data were used for the base-case analysis. Sensitivity analyses employing various sources of resources use and costs were performed. Costs were uprated to 2015US$. Multiple linear regression was conducted to explore the predictors of societal costs. The mean 6-month societal costs were estimated at $9,258.39. The larger part was attributable to healthcare costs (91.7%), while costs to patient and family and costs in other sectors poorly contributed to the total costs (4.2% and 4.1%, respectively). In general, results were robust to sensitivity analyses. Using the maximum value for hospitalization resulted in the biggest difference (+15.5% of the base-case result). Female gender, being widowed/divorced, having hypertension comorbidity, and higher weekly time on dialysis were significantly associated with greater societal costs. Information regarding resource consumption and cost were not readily available. Rather, they were obtained from a variety of sources, with each having its own strengths and limitations. Hemodialysis represents a high societal burden in Lebanon. Using extrapolation, its total annual cost for the Lebanese society is estimated at $61,105,374 and the mean total annual cost ($18,516.7) is 43.70% higher than the gross domestic product per capita forecast for 2015. Measures to reduce the economic burden of hemodialysis should be taken, by promoting

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G. Gomez and J. Pivarski

2011-01-01

Alignment efforts in the first few months of 2011 have shifted away from providing alignment constants (now a well established procedure) and focussed on some critical remaining issues. The single most important task left was to understand the systematic differences observed between the track-based (TB) and hardware-based (HW) barrel alignments: a systematic difference in r-φ and in z, which grew as a function of z, and which amounted to ~4-5 mm differences going from one end of the barrel to the other. This difference is now understood to be caused by the tracker alignment. The systematic differences disappear when the track-based barrel alignment is performed using the new “twist-free” tracker alignment. This removes the largest remaining source of systematic uncertainty. Since the barrel alignment is based on hardware, it does not suffer from the tracker twist. However, untwisting the tracker causes endcap disks (which are aligned ...

MUON DETECTORS: ALIGNMENT

CERN Multimedia

Gervasio Gomez

The main progress of the muon alignment group since March has been in the refinement of both the track-based alignment for the DTs and the hardware-based alignment for the CSCs. For DT track-based alignment, there has been significant improvement in the internal alignment of the superlayers inside the DTs. In particular, the distance between superlayers is now corrected, eliminating the residual dependence on track impact angles, and good agreement is found between survey and track-based corrections. The new internal geometry has been approved to be included in the forthcoming reprocessing of CRAFT samples. The alignment of DTs with respect to the tracker using global tracks has also improved significantly, since the algorithms use the latest B-field mapping, better run selection criteria, optimized momentum cuts, and an alignment is now obtained for all six degrees of freedom (three spatial coordinates and three rotations) of the aligned DTs. This work is ongoing and at a stage where we are trying to unders...

A Multi-Objective Method to Align Human Resource Allocation with University Strategy

Science.gov (United States)

Bouillard, Philippe

2016-01-01

Universities are currently under considerable pressure to reach their stakeholders' expectations. Management tools that use strategic plans, key performance indicators and quality assurance methods are increasingly deployed. This paper aims to demonstrate how resource allocation can be aligned with institutional strategic plans with a very simple…

Beyond Climate and Weather Science: Expanding the Forecasting Family to Serve Societal Needs

Science.gov (United States)

Barron, E. J.

2009-05-01

The ability to "anticipate" the future is what makes information from the Earth sciences valuable to society - whether it is the prediction of severe weather or the future availability of water resources in response to climate change. An improved ability to anticipate or forecast has the potential to serve society by simultaneously improving our ability to (1) promote economic vitality, (2) enable environmental stewardship, (3) protect life and property, as well as (4) improve our fundamental knowledge of the earth system. The potential is enormous, yet many appear ready to move quickly toward specific mitigation and adaptation strategies assuming that the science is settled. Five important weakness must be addressed first: (1) the formation of a true "climate services" function and capability, (2) the deliberate investment in expanding the family of forecasting elements to incorporate a broader array of environmental factors and impacts, (3) the investment in the sciences that connect climate to society, (4) a deliberate focus on the problems associated with scale, in particular the difference between the scale of predictive models and the scale associated with societal decisions, and (5) the evolution from climate services and model predictions to the equivalent of "environmental intelligence centers." The objective is to bring the discipline of forecasting to a broader array of environmental challenges. Assessments of the potential impacts of global climate change on societal sectors such as water, human health, and agriculture provide good examples of this challenge. We have the potential to move from a largely reactive mode in addressing adverse health outcomes, for example, to one in which the ties between climate, land cover, infectious disease vectors, and human health are used to forecast and predict adverse human health conditions. The potential exists for a revolution in forecasting, that entrains a much broader set of societal needs and solutions. The

Shaping Societal Impact: between control and cooperation

NARCIS (Netherlands)

Messemaker, M.; Wolbers, J.J.; Treurniet, W.; Boersma, F.K.; Comes, T; Fiedrich, F; Fortier, S; Geldermann, J; Muller, T

2013-01-01

In our modern society, the impact of large-scale safety and security incidents can be large and diverse. Yet, this societal impact is makeable and controllable to a limited extent. At best, the effect of concrete response actions is that the direct damage is somewhat reduced and that the recovery is

Atomoxetine's Effect on Societal Costs in Sweden

Science.gov (United States)

Myren, Karl-Johan; Thernlund, Gunilla; Nylen, Asa; Schacht, Alexander; Svanborg, Par

2010-01-01

Objective: To compare societal costs between patients treated with atomoxetine and placebo in Sweden. Method: Ninety-nine pediatric ADHD patients were randomized to a 10-week double-blind treatment with atomoxetine (n = 49) or placebo (n = 50). All parents received four sessions of psycho-education. Parents filled out a resource utilization…

Societe d'energie de la Baie James, progress report 1991

International Nuclear Information System (INIS)

1992-01-01

The Societe d'energie de la Baie James is a wholly owned subsidiary of Hydro-Quebec and is responsible for harnessing the hydroelectric resources of the James Bay territory. The Societe executes, manages, and administers the design and construction of hydroelectric development projects in the James Bay territory as well as any other project assigned by Hydro-Quebec. In 1991, the Societe saw its strongest surge of activity since development projects were resumed in 1986. Work at the La Grande -2A, La Grande-1, Laforge-1, and Brisay developments, representing over 4,500 MW of installed capacity, continued in compliance with schedules and cost projections. The first three turbine generator units of La Grande-2A were commissioned and detailed design continued for Laforge-2 and Eastmain-1. At LaGrande-1, the spillway and two embankments were completed; at Brisay,excavation of headrace tunnels and the tailbay of the power station were completed; and in total, over $500 million in contracts and $54 million in purchases were made in 1991. 15 figs., 2 tabs

Societal impact metrics for non-patentable research in dentistry

Energy Technology Data Exchange (ETDEWEB)

Hicks, D.; Isett, K.; Melkers, J.; Song, L.; Trivedi, R.

2016-07-01

Indicators of research impact tend to revolve around patents, licenses and startups. However, much university research is non-patentable and therefore doesn’t register in those metrics. That does not mean such research lacks impact, just that it follows different pathways to use in society. Without the visibility of patents, license income and jobs created in startups, society risks ignoring or discounting the societal impact of such research and therefore of undervaluing the research itself. In order to make visible the importance of research advances underpinning broader societal advance, in this project we explore the possibility of developing metrics of research impact for research whose results are relevant to professional practice. (Author)

Grand societal challenges in information systems research and education

CERN Document Server

vom Brocke, Jan; Hofmann, Sara; Tumbas, Sanja

2015-01-01

This book examines how information systems research and education can play a major role in contributing to solutions to the Societal Grand Challenges formulated in "The Millennium Project" (millenium-project.org). Individual chapters focus on specific challenges, review existing approaches and contributions towards solutions in information systems research and outline a research agenda for these challenges. The topics considered in this volume range from climate change, population growth, global ICT availability, breakthroughs in science and technology and energy demand to ethical decision-making, policymaking, gender status and transnational crime prevention. It is the first book to present ideas on how the Information Systems discipline can contribute to the solution on this wide spectrum of grand societal challenges.

Understanding societal impact through productive interactions: ICT research as a case

OpenAIRE

Stefan de Jong; Katharine Barker; Deborah Cox; Thordis Sveinsdottir; Peter Van den Besselaar

2014-01-01

Universities are increasingly expected to fulfill a third mission in addition to those of research and education. Universities must demonstrate engagement with society through the application and exploitation of knowledge. As societal impact of research is uncertain, long term and always dependent on other factors, we argue here that evaluation should focus on the conditions under which societal impact is generated rather than on the impact itself. Here we focus on a specific set of those con...

Coastal defence and societal activities in the coastal zone: Compatible or conflicting interests?

NARCIS (Netherlands)

van Vuren, Saskia; Kok, Matthijs; Jorissen, Richard E.

2004-01-01

World-wide coastal zones are subject to physical and societal changes. Due to climate change sea level is expected to rise and storm conditions may become more intensive. Both may lead to shore erosion intensification in the coastal zone. Moreover, the coastal zone is intensely used for societal

When Inequality Fails: Power, Group Dominance, and Societal Change

Directory of Open Access Journals (Sweden)

Felicia Pratto

2013-12-01

Full Text Available Social dominance theory was developed to account for why societies producing surplus take and maintain the form of group-based dominance hierarchies, in which at least one socially-constructed group has more power than another, and in which men are more powerful than women and adults more powerful than children. Although the theory has always allowed for societies to differ in their severity of group-based dominance and how it is implemented, it has predicted that alternative forms of societal organization will occur rarely and not last. This paper revisits aspects of the theory that allow for the possibility of societal alternatives and change. We also consider boundary conditions for the theory, and whether its current theoretical apparatus can account for societal change. By expanding the typical three-level dynamic system to describe societies (micro-meso-macro into four levels (including meta to consider how societies relate to one another, we identify political tensions that are unstable power structures rather than stable hierarchies. In research on institutions, we identify smaller-scale alternative forms of social organization. We identify logical, empirical, and theoretical shortcomings in social dominance theory’s account of stability and change, consider alternative forms of social organization, and suggest fruitful avenues for theoretical extension.

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G.Gomez

2011-01-01

The Muon Alignment work now focuses on producing a new track-based alignment with higher track statistics, making systematic studies between the results of the hardware and track-based alignment methods and aligning the barrel using standalone muon tracks. Currently, the muon track reconstruction software uses a hardware-based alignment in the barrel (DT) and a track-based alignment in the endcaps (CSC). An important task is to assess the muon momentum resolution that can be achieved using the current muon alignment, especially for highly energetic muons. For this purpose, cosmic ray muons are used, since the rate of high-energy muons from collisions is very low and the event statistics are still limited. Cosmics have the advantage of higher statistics in the pT region above 100 GeV/c, but they have the disadvantage of having a mostly vertical topology, resulting in a very few global endcap muons. Only the barrel alignment has therefore been tested so far. Cosmic muons traversing CMS from top to bottom are s...

Review of alignment activities for indus-1 and 2 at CAT

International Nuclear Information System (INIS)

Nema, P.K.; Sahu, R.K.; Prasad, V.

1999-01-01

Survey and alignment activities at CAT (Centre for Advanced Technology - India) are related to two accelerator projects called INDUS-1 and INDUS -2. Former is a 450 MeV SRS and latter is a 2.5 GeV SRS. Both the machines use a 450/700 MeV booster synchrotron and 20 MeV pre-injector microtron for injection. Indus-1 was commissioned with 100 mA stored beam current in May 1999. Indus-2 is under construction and expected to be commissioned within next 4 years. Survey and alignment work of booster synchrotron and Indus-1 (storage ring) was accomplished using optical surveying techniques with software ECDS-2 of Kern. That was possible due to small size of machines of Indus-1. For Indus-2 with circumference of 172.47 m, the network surveying and alignment scheme has been planned. Indus-2 is a high brilliance machine and this puts more stringent requirements on alignment. This paper describes methodology and performance results of Indus-1 alignment and strategy for Indus-2. (authors)

Prospective of Societal and Environmental Benefits of Piezoelectric Technology in Road Energy Harvesting

Directory of Open Access Journals (Sweden)

Lubinda F. Walubita

2018-02-01

Full Text Available Road energy harvesting is an ingenious horizon for clean and renewable energy production. The concept is very compatible with current traffic trends and the ongoing depletion of natural resources. Yet, the idea of harvesting roadway energy is still in its genesis, and only a few real-time implementation projects have been reported in the literature. This review article summarizes the current state of the art in road energy harvesting technology, with a focus on piezoelectric systems, including an analysis of the impact of the technology from social and environmental standpoints. Based on an extensive desktop review study, this article provides a comprehensive insight into roadway energy harvesting technologies. Specifically, the article discusses the societal and environmental benefits of road energy harvesting technologies, as well as the challenges. The study outlined the meaningful benefits that positively align with the concept of sustainability. Overall, the literature findings indicate that the expansion of the roadway energy harvesting technology to a large practical scale is feasible, but such an undertaking should be wisely weighed from broader perspectives. Ultimately, the article provides a positive outlook of the potential contributions of road energy harvesting technologies to the ongoing energy and environmental challenges of human society.

Empowering Graduate Students to Lead on Interdisciplinary Societal Issues

Science.gov (United States)

Grubert, E.

2015-12-01

than problem-spotting activities with stakeholders. The ELISS strategy of establishing a cultural norm that young scientists can and should engage global societal issues is a novel approach to fostering leadership skills and interdisciplinary comfort that can readily be translated to both academic and nonacademic success.

Automated alignment of optical components for high-power diode lasers

Science.gov (United States)

Brecher, C.; Pyschny, N.; Haag, S.; Guerrero Lule, V.

2012-03-01

Despite major progress in developing brilliant laser sources a huge potential for cost reductions can be found in simpler setups and automated assembly processes, especially for large volume applications. In this presentation, a concept for flexible automation in optics assembly is presented which is based on standard micro assembly systems with relatively large workspace and modular micromanipulators to enhance the system with additional degrees of freedom and a very high motion resolution. The core component is a compact flexure-based micromanipulator especially designed for the alignment of micro optical components which will be described in detail. The manipulator has been applied in different scenarios to develop and investigate automated alignment processes. This paper focuses on the automated alignment of fast axis collimation (FAC) lenses which is a crucial step during the production of diode lasers. The handling and positioning system, the measuring arrangement for process feedback during active alignment as well as the alignment strategy will be described. The fine alignment of the FAC lens is performed with the micromanipulator under concurrent analysis of the far and the near field intensity distribution. An optimization of the image processing chains for the alignment of a FAC in front of a diode bar led to cycle times of less than 30 seconds. An outlook on other applications and future work regarding the development of automated assembly processes as well as new ideas for flexible assembly systems with desktop robots will close the talk.

Alignment-Annotator web server: rendering and annotating sequence alignments.

Science.gov (United States)

Gille, Christoph; Fähling, Michael; Weyand, Birgit; Wieland, Thomas; Gille, Andreas

2014-07-01

Alignment-Annotator is a novel web service designed to generate interactive views of annotated nucleotide and amino acid sequence alignments (i) de novo and (ii) embedded in other software. All computations are performed at server side. Interactivity is implemented in HTML5, a language native to web browsers. The alignment is initially displayed using default settings and can be modified with the graphical user interfaces. For example, individual sequences can be reordered or deleted using drag and drop, amino acid color code schemes can be applied and annotations can be added. Annotations can be made manually or imported (BioDAS servers, the UniProt, the Catalytic Site Atlas and the PDB). Some edits take immediate effect while others require server interaction and may take a few seconds to execute. The final alignment document can be downloaded as a zip-archive containing the HTML files. Because of the use of HTML the resulting interactive alignment can be viewed on any platform including Windows, Mac OS X, Linux, Android and iOS in any standard web browser. Importantly, no plugins nor Java are required and therefore Alignment-Anotator represents the first interactive browser-based alignment visualization. http://www.bioinformatics.org/strap/aa/ and http://strap.charite.de/aa/. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Screaming at a Wall. Societal accountability from below in Bulgaria and Hungary

Directory of Open Access Journals (Sweden)

Andrea L.P. Pirro

2018-01-01

Full Text Available The article investigates engagement in anti-corruption activism in Bulgaria and Hungary. Since the late 2000s, protest events occurred in greater numbers in the two post-communist countries, addressing questions either directly or indirectly related to high-level or political corruption. Bulgarian and Hungarian collective anti-corruption actors share a common framing of the issue ('state corruption' or 'state capture', though their struggles vary in their modes and strategies ('civic self-organisation' versus the dominant role of 'transactional activism'. The article crucially reconstructs the context within which anticorruption activism took place, the different forms of mobilisation, and the specific framing of the issue by means of original interviews with prominent Bulgarian and Hungarian activists. Finally, attention is devoted to the subaltern fortunes of these struggles in attaining the aspired goal of societal accountability.

Physics of societal issues calculations on national security, environment, and energy

CERN Document Server

Hafemeister, David

2007-01-01

Why this book on the Physics of Societal Issues? The subdivisions of physics - nuclear physics, particle physics, condensed-matter physics, biophysics - have their textbooks, while the subdivision of physics and society lacks an equation-oriented text on the physics of arms, energy and the environment. Physics of Societal Issues is intended for undergraduate and doctoral students who may work on applied topics, or who simply want to know why things are the way they are. Decisions guiding policies on nuclear arms, energy and the environment often seem mysterious and contradictory. What is the science behind the deployment of MIRVed ICBMs, the quest for space-based beam weapons, the fear of powerline EM fields, the wholesale acceptance of SUVs, the issues of climactic change, and the failure of the pre-embargo market to produce buildings and appliances that now save over 50 power plants? Physics of Societal Issues is three "mini-texts" in one: National Security (5 chapters): Weapons, offense, defense, verificat...

Advances in complex societal, environmental and engineered systems

CERN Document Server

Essaaidi, Mohammad

2017-01-01

This book addresses recent technological progress that has led to an increased complexity in many natural and artificial systems. The resulting complexity research due to the emergence of new properties and spatio-temporal interactions among a large number of system elements - and between the system and its environment - is the primary focus of this text. This volume is divided into three parts: Part one focuses on societal and ecological systems, Part two deals with approaches for understanding, modeling, predicting and mastering socio-technical systems, and Part three includes real-life examples. Each chapter has its own special features; it is a self-contained contribution of distinguished experts working on different fields of science and technology relevant to the study of complex systems. Advances in Complex Systems of Contemporary Reality: Societal, Environmental and Engineered Systems will provide postgraduate students, researchers and managers with qualitative and quantitative methods for handling th...

Creating Societal Benefits and Corporate Profits

OpenAIRE

Raisch, Sebastian; Probst, Gilbert; Gomez, Peter; Zimmermann, Alexander

2014-01-01

The odds of launching a new business that creates value for both the company and the public can be improved with good planning. An in-depth analysis of how four companies created for-profit initiatives that also have high societal value suggests that each followed a similar step-by-step process to achieve what the researchers call synergistic value creation. Those steps include establishing cross-business incubators and installing multi-perspective monitoring systems.

EURRECA: development of tools to improve the alignment of micronutrient recommendations

NARCIS (Netherlands)

Matthys, C.; Bucchini, L.; Busstra, M.C.; Cavelaars, A.J.E.M.; Eleftheriou, P.; Garcia-Alvarez, A.; Fairweather-Tait, S.; Gurinovic, M.; Ommen, van B.; Contor, L.

2010-01-01

Approaches through which reference values for micronutrients are derived, as well as the reference values themselves, vary considerably across countries. Harmonisation is needed to improve nutrition policy and public health strategies. The EURRECA (EURopean micronutrient RECommendations Aligned,

Societal Conditions and the Gender Difference in Well-Being: Testing a Three-Stage Model.

Science.gov (United States)

Zuckerman, Miron; Li, Chen; Diener, Edward F

2017-03-01

Findings from a meta-analysis on gender differences in self-esteem (Zuckerman et al., 2016) suggest that the relation between the degree to which societal conditions are favorable to women and gender difference in self-esteem might be quadratic; when conditions improve, women's self-esteem (relative to that of men) trends downward but when conditions continue to improve, women's self-esteem begins to trend upward. Testing whether these relations generalize to subjective well-being, the present study found a quadratic relation between improving societal conditions and the gender difference in life satisfaction and positive affect (women are lower than men when societal conditions are moderately favorable compared to when they are at their worst and at their best); the relation was linear for negative emotion (women report more negative emotions than men when societal conditions are better). Directions for future research that will address potential explanations for these results are proposed.

Price leadership strategy or branding strategy:an empirical test of indigenous Chinese exporters

Institute of Scientific and Technical Information of China (English)

无

2008-01-01

The effects of price leadership strategies and branding strategies on the export performance of indigenous Chinese exporters with a focus on developing country markets and developed country markets are examined based on the principles of strategy-environment co-alignment and marketing segmentation theory. Findings suggest that when focusing on developing country markets, the use of a branding strategy is more likely to enhance export performance. When focusing on developed country markets, neither the use o...

HOW FUTURE MANAGERS VIEW SOCIETAL CULTURE: A CROSS-COUNTRY COMPARISON

Directory of Open Access Journals (Sweden)

CATANA DOINA

2011-07-01

Full Text Available Our study aims at enriching the existing literature about the prospective managers view of an ideal societal value system and the existing cultural practices in their society. The findings about the students' perception on cultural practices and their expectations about societal culture are helpful in imagining the societal culture in its dynamics. The research sample consists of 727 students in business and engineering on undergraduate and graduate levels from Romania and Slovenia. The reason we have chosen to compare Romanian sample with the cultural profile of the "average" future manager from Slovenia is the scientific curiosity of finding out if there are signs of cultural convergence of Romania with a previous communist country, and an older member of European Union. In doing so, our study will hopefully broaden the body of knowledge about the cultural convergence (or divergence? between the former socialist countries joining European Union. The theoretical and methodological foundation is rooted in GLOBE international research project. Our findings revealed that at practices level,Romanians perceive significant higher Power Distance and significant lower mean value for Uncertainty Avoidance. At the expectations level, the Romanians and Slovenians are very similar in the desire concerning their societies orientation toward In group/Family Collectivism, Assertiveness and Performance Orientation, and record significant differenced in all the other societal values. The fact that for all the cultural expectations the future managers assign different mean values than for the correspondent practices make us expect that they will act to change their cultural environments. Still, the cultural orientation of Romanian future middle managers will differ in many regards from the Slovenian sample averages.

Alignment of the ATLAS Inner Detector in the LHC Run II

CERN Document Server

Barranco Navarro, Laura; The ATLAS collaboration

2015-01-01

ATLAS physics goals require excellent resolution, unbiased measurement of all charged particle kinematic parameters. These critically depend on the layout and performance of the tracking system and on the quality of its offline alignment. ATLAS is equipped with a tracking system built using different technologies, silicon planar sensors (pixel and micro-strip) and gaseous drift- tubes, all embedded in a 2T solenoidal magnetic field. For the Run II of the LHC, the system was upgraded with the installation of a new pixel layer, the Insertable B-layer (IBL). An outline of the track based alignment approach and its implementation within the ATLAS software will be presented. Special attention will be paid to integration of the IBL into the alignment framework, techniques allowing to identify and eliminate tracking systematics as well as strategies to deal with time-dependent alignment. Performance from the commissioning of Cosmic data and potentially early LHC Run II proton-proton collisions will be discussed.

RevTrans: multiple alignment of coding DNA from aligned amino acid sequences

DEFF Research Database (Denmark)

Wernersson, Rasmus; Pedersen, Anders Gorm

2003-01-01

The simple fact that proteins are built from 20 amino acids while DNA only contains four different bases, means that the 'signal-to-noise ratio' in protein sequence alignments is much better than in alignments of DNA. Besides this information-theoretical advantage, protein alignments also benefit...... proteins. It is therefore preferable to align coding DNA at the amino acid level and it is for this purpose we have constructed the program RevTrans. RevTrans constructs a multiple DNA alignment by: (i) translating the DNA; (ii) aligning the resulting peptide sequences; and (iii) building a multiple DNA...

Opportunities for Increasing Societal Value of Remote Sensing Data ...

African Journals Online (AJOL)

Opportunities for Increasing Societal Value of Remote Sensing Data in South Africa's Strategic Development Priorities: A Review. ... Despite the enormous capital required to fund remote sensing initiatives, governments ... HOW TO USE AJOL.

Graceful Failure and Societal Resilience Analysis Via Agent-Based Modeling and Simulation

Science.gov (United States)

Schopf, P. S.; Cioffi-Revilla, C.; Rogers, J. D.; Bassett, J.; Hailegiorgis, A. B.

2014-12-01

Agent-based social modeling is opening up new methodologies for the study of societal response to weather and climate hazards, and providing measures of resiliency that can be studied in many contexts, particularly in coupled human and natural-technological systems (CHANTS). Since CHANTS are complex adaptive systems, societal resiliency may or may not occur, depending on dynamics that lack closed form solutions. Agent-based modeling has been shown to provide a viable theoretical and methodological approach for analyzing and understanding disasters and societal resiliency in CHANTS. Our approach advances the science of societal resilience through computational modeling and simulation methods that complement earlier statistical and mathematical approaches. We present three case studies of social dynamics modeling that demonstrate the use of these agent based models. In Central Asia, we exmaine mutltiple ensemble simulations with varying climate statistics to see how droughts and zuds affect populations, transmission of wealth across generations, and the overall structure of the social system. In Eastern Africa, we explore how successive episodes of drought events affect the adaptive capacity of rural households. Human displacement, mainly, rural to urban migration, and livelihood transition particularly from pastoral to farming are observed as rural households interacting dynamically with the biophysical environment and continually adjust their behavior to accommodate changes in climate. In the far north case we demonstrate one of the first successful attempts to model the complete climate-permafrost-infrastructure-societal interaction network as a complex adaptive system/CHANTS implemented as a ``federated'' agent-based model using evolutionary computation. Analysis of population changes resulting from extreme weather across these and other cases provides evidence for the emergence of new steady states and shifting patterns of resilience.

Societal development and the impact of information technology ...

African Journals Online (AJOL)

There are several theories on societal development, especially concerning issues that are affecting globalization. Those issues include the impact of information technology on developing countries of Africa, the social and cultural schools of thought on globalization of information technology, the defining issues that are ...

Long Read Alignment with Parallel MapReduce Cloud Platform

Directory of Open Access Journals (Sweden)

Ahmed Abdulhakim Al-Absi

2015-01-01

Full Text Available Genomic sequence alignment is an important technique to decode genome sequences in bioinformatics. Next-Generation Sequencing technologies produce genomic data of longer reads. Cloud platforms are adopted to address the problems arising from storage and analysis of large genomic data. Existing genes sequencing tools for cloud platforms predominantly consider short read gene sequences and adopt the Hadoop MapReduce framework for computation. However, serial execution of map and reduce phases is a problem in such systems. Therefore, in this paper, we introduce Burrows-Wheeler Aligner’s Smith-Waterman Alignment on Parallel MapReduce (BWASW-PMR cloud platform for long sequence alignment. The proposed cloud platform adopts a widely accepted and accurate BWA-SW algorithm for long sequence alignment. A custom MapReduce platform is developed to overcome the drawbacks of the Hadoop framework. A parallel execution strategy of the MapReduce phases and optimization of Smith-Waterman algorithm are considered. Performance evaluation results exhibit an average speed-up of 6.7 considering BWASW-PMR compared with the state-of-the-art Bwasw-Cloud. An average reduction of 30% in the map phase makespan is reported across all experiments comparing BWASW-PMR with Bwasw-Cloud. Optimization of Smith-Waterman results in reducing the execution time by 91.8%. The experimental study proves the efficiency of BWASW-PMR for aligning long genomic sequences on cloud platforms.

Severe Space Weather Events--Understanding Societal and Economic Impacts: A Workshop Report - Extended Summary

Science.gov (United States)

2009-01-01

The effects of space weather on modern technological systems are well documented in both the technical literature and popular accounts. Most often cited perhaps is the collapse within 90 seconds of northeastern Canada's Hydro-Quebec power grid during the great geomagnetic storm of March 1989, which left millions of people without electricity for up to 9 hours. This event exemplifies the dramatic impact that severe space weather can have on a technology upon which modern society critically depends. Nearly two decades have passed since the March 1989 event. During that time, awareness of the risks of severe space weather has increased among the affected industries, mitigation strategies have been developed, new sources of data have become available, new models of the space environment have been created, and a national space weather infrastructure has evolved to provide data, alerts, and forecasts to an increasing number of users. Now, 20 years later and approaching a new interval of increased solar activity, how well equipped are we to manage the effects of space weather? Have recent technological developments made our critical technologies more or less vulnerable? How well do we understand the broader societal and economic impacts of severe space weather events? Are our institutions prepared to cope with the effects of a 'space weather Katrina,' a rare, but according to the historical record, not inconceivable eventuality? On May 22 and 23, 2008, a one-and-a-half-day workshop held in Washington, D.C., under the auspices of the National Research Council's (NRC's) Space Studies Board brought together representatives of industry, the federal government, and the social science community to explore these and related questions. The key themes, ideas, and insights that emerged during the presentations and discussions are summarized in 'Severe Space Weather Events--Understanding Societal and Economic Impacts: A Workshop Report' (The National Academies Press, Washington, D

Internalized societal attitudes moderate the impact of weight stigma on avoidance of exercise.

Science.gov (United States)

Vartanian, Lenny R; Novak, Sarah A

2011-04-01

Experiences with weight stigma negatively impact both psychological outcomes (e.g., body dissatisfaction, depression) and behavioral outcomes (e.g., dieting, exercise). However, not everyone is equally affected by experiences with weight stigma. This study examined whether internalized societal attitudes about weight moderated the impact of weight stigma. Adult participants (n = 111) completed measures of experiences with weight stigma, as well as two indexes of internalized societal attitudes (the moderators): Internalized anti-fat attitudes and internalization of societal standards of attractiveness. Psychological outcomes included self-esteem, body dissatisfaction, drive for thinness, and bulimic symptoms; behavioral outcomes included avoidance of exercise and self-reported exercise behavior. Weight stigma was positively correlated with body dissatisfaction, drive for thinness, and bulimic symptoms, and was negatively correlated with state and trait self-esteem. Both indexes of internalized attitudes moderated the association between weight stigma and avoidance of exercise: Individuals high in anti-fat attitudes and high in internalization of societal standards of attractiveness were more motivated to avoid exercise if they also experienced a high degree of weight stigma; individuals low in anti-fat attitudes and low in internalization were relatively unaffected. Avoidance of exercise was negatively correlated with self-reported strenuous exercise. These findings suggest that weight stigma can negatively influence motivation to exercise, particularly among individuals who have internalized societal attitudes about weight. Reducing internalization might be a means of minimizing the negative impact of weight stigma and of facilitating healthy weight management efforts.

Acute alcohol intoxication impairs segmental body alignment in upright standing.

Science.gov (United States)

Hafstrom, A; Patel, M; Modig, F; Magnusson, M; Fransson, P A

2014-01-01

Balance control when standing upright is a complex process requiring input from several partly independent mechanisms such as coordination, feedback and feedforward control, and adaptation. Acute alcohol intoxication from ethanol is recognized as a major contributor to accidental falls requiring medical care. This study aimed to investigate if intoxication at 0.06 and 0.10% blood alcohol concentration affected body alignment. Mean angular positions of the head, shoulder, hip, and knee were measured with 3D-motion analysis and compared with the ankle position in 25 healthy adults during standing with or without perturbations, and with eyes open or closed. Alcohol intoxication had significant effects on body alignment during perturbed and unperturbed stance, and on adaptation to perturbations. It induced a significantly more posterior alignment of the knees and shoulders, and a tendency for a more posterior and left deviated head alignment in perturbed stance than when sober. The impact of alcohol intoxication was most apparent on the knee alignment, where availability of visual information deteriorated the adaptation to perturbations. Thus, acute alcohol intoxication resulted in inadequate balance control strategies with increased postural rigidity and impaired adaptation to perturbations. These factors probably contribute to the increased risk of falling when intoxicated with alcohol.

Societal entrepreneurship and its significance for a practical ...

African Journals Online (AJOL)

2011-10-05

Oct 5, 2011 ... First of all, our motivation to focus on society and social ... societal entrepreneurs are particularly focused on network .... hospitality and tourism industry (Orsmond 2008a:195−196; ..... built on previous experience and technical knowledge as ... nevertheless committed to letting their employees share in.

Lorenzo Cini, Società civile e democrazia radicale

Directory of Open Access Journals (Sweden)

Maria Chiara Pievatolo

2013-02-01

Full Text Available La nostra collana Methexis ha pubblicato ad accesso aperto il volume di Lorenzo Cini, Società civile e democrazia radicale, Firenze, Firenze University Press, 2012. La versione digitale del testo, in formato PDF, è a disposizione di tutti presso l’archivio elettronico dell'editore.

The appeal of nostalgia: the influence of societal pessimism on support for populist radical right parties

OpenAIRE

Steenvoorden, E. (Eefje); Harteveld, E. (Eelco)

2017-01-01

textabstractIn the literature, explanations of support for populist radical right (PRR) parties usually focus on voters’ socio-structural grievances, political discontent or policy positions. This article suggests an additional and possibly overarching explanation: societal pessimism. The central argument is that the nostalgic character of PRR ideology resonates with societal pessimism among its voters. Using European Social Survey data from 2012, the study compares levels of societal pessimi...

On the move to business alignment of service monitoring requirements

NARCIS (Netherlands)

de Alencar Silva, P.; Weigand, H.; van Sinderen, M.; Johnson, P.S.; de Alencar Silva, P.

2011-01-01

Current service monitoring capabilities have been not designed in alignment with business needs. We argue that service monitoring should be primarily thought of as an economic concern, with proper needs being elicited on the business strategy level and further drilled down to process and IT services

Supply chain collaboration aligns order-winning strategy with business outcomes

Directory of Open Access Journals (Sweden)

Pongpak Banchuen

2017-06-01

Full Text Available The paper aims to find out whether appropriate choice of collaboration will enable the required order-winners, leading to improved business outcomes. Structural equation modelling (SEM was employed with cross-sectional data to test the hypothesised relationships among order-winners, modes of collaboration, and business outcomes. Results indicate that firms that focus on flexibility, quality, and delivery should develop strategic collaboration with suppliers to achieve market and innovation improvement. Cost- and quality-focussed firms should develop operational collaboration to achieve resource efficiency. The model allows managers to understand the right alignment of external suppliers while working on their own order-winners being pursued to win business performance.

Mechanical alignment based on beam diagnostics

International Nuclear Information System (INIS)

Farvacque, L.; Martin, D.; Nagaoka, R.

1999-01-01

This article studies the consequences of misalignment of the different components on the displacement of the beam. 3 types of motion have been investigated: quadrupole vertical displacement, quadrupole tilt and sextupole vertical displacement. For each shift a response matrix has been designed and from this formulation, aligning quadrupoles means inverting this matrix. The strategy for correction depends on the accuracy of the response matrix and on the quality of the beam position measurements. A modelling of the corrections is proposed. (A.C.)

How the Spectre of Societal Homogeneity Undermines Equitable Healthcare for Refugees

Science.gov (United States)

Razum, Oliver; Wenner, Judith; Bozorgmehr, Kayvan

2017-01-01

Recourse to a purported ideal of societal homogeneity has become common in the context of the refugee reception crisis – not only in Japan, as Leppold et al report, but also throughout Europe. Calls for societal homogeneity in Europe originate from populist movements as well as from some governments. Often, they go along with reduced social support for refugees and asylum seekers, for example in healthcare provision. The fundamental right to health is then reduced to a citizens’ right, granted fully only to nationals. Germany, in spite of welcoming many refugees in 2015, is a case in point: entitlement and access to healthcare for asylum seekers are restricted during the first 15 months of their stay. We show that arguments brought forward to defend such restrictions do not hold, particularly not those which relate to maintaining societal homogeneity. European societies are not homogeneous, irrespective of migration. But as migration will continue, societies need to invest in what we call "globalization within." Removing entitlement restrictions and access barriers to healthcare for refugees and asylum seekers is one important element thereof. PMID:28812828

MUON DETECTORS: ALIGNMENT

CERN Multimedia

S. Szillasi

2013-01-01

The CMS detector has been gradually opened and whenever a wheel became exposed the first operation was the removal of the MABs, the sensor structures of the Hardware Barrel Alignment System. By the last days of June all 36 MABs have arrived at the Alignment Lab at the ISR where, as part of the Alignment Upgrade Project, they are refurbished with new Survey target holders. Their electronic checkout is on the way and finally they will be recalibrated. During LS1 the alignment system will be upgraded in order to allow more precise reconstruction of the MB4 chambers in Sector 10 and Sector 4. This requires new sensor components, so called MiniMABs (pictured below), that have already been assembled and calibrated. Image 6: Calibrated MiniMABs are ready for installation For the track-based alignment, the systematic uncertainties of the algorithm are under scrutiny: this study will enable the production of an improved Monte Carlo misalignment scenario and to update alignment position errors eventually, crucial...

Pediatric cryptosporidiosis: An evaluation of health care and societal costs in Peru, Bangladesh and Kenya.

Directory of Open Access Journals (Sweden)

Ellen R Rafferty

Full Text Available Cryptosporidium is a leading cause of pediatric diarrhea in resource-limited settings; yet, few studies report the health care costs or societal impacts of this protozoan parasite. Our study examined direct and indirect costs associated with symptomatic cryptosporidiosis in infants younger than 12 months in Kenya, Peru and Bangladesh. Inputs to the economic burden model, such as disease incidence, population size, health care seeking behaviour, hospital costs, travel costs, were extracted from peer-reviewed literature, government documents, and internationally validated statistical tools for each country. Indirect losses (i.e. caregiver income loss, mortality, and growth faltering were also estimated. Our findings suggest that direct treatment costs per symptomatic cryptosporidiosis episode were highest in Kenya ($59.01, followed by Peru ($23.32, and Bangladesh ($7.62. The total annual economic impacts for the 0-11 month cohorts were highest in Peru ($41.5M; range $0.88-$599.3M, followed by Kenya ($37.4M; range $1.6-$804.5M and Bangladesh ($9.6M, range $0.28-$91.5M. For all scenarios, indirect societal costs far outweighed direct treatment costs. These results highlight the critical need for innovative improvements to current prevention, diagnostic and treatment strategies available in resource poor settings, as well as the need for solutions that span multiple disciplines including food and water safety, sanitation and livestock production.

Pediatric cryptosporidiosis: An evaluation of health care and societal costs in Peru, Bangladesh and Kenya.

Science.gov (United States)

Rafferty, Ellen R; Schurer, Janna M; Arndt, Michael B; Choy, Robert K M; de Hostos, Eugenio L; Shoultz, David; Farag, Marwa

2017-01-01

Cryptosporidium is a leading cause of pediatric diarrhea in resource-limited settings; yet, few studies report the health care costs or societal impacts of this protozoan parasite. Our study examined direct and indirect costs associated with symptomatic cryptosporidiosis in infants younger than 12 months in Kenya, Peru and Bangladesh. Inputs to the economic burden model, such as disease incidence, population size, health care seeking behaviour, hospital costs, travel costs, were extracted from peer-reviewed literature, government documents, and internationally validated statistical tools for each country. Indirect losses (i.e. caregiver income loss, mortality, and growth faltering) were also estimated. Our findings suggest that direct treatment costs per symptomatic cryptosporidiosis episode were highest in Kenya ($59.01), followed by Peru ($23.32), and Bangladesh ($7.62). The total annual economic impacts for the 0-11 month cohorts were highest in Peru ($41.5M; range $0.88-$599.3M), followed by Kenya ($37.4M; range $1.6-$804.5M) and Bangladesh ($9.6M, range $0.28-$91.5M). For all scenarios, indirect societal costs far outweighed direct treatment costs. These results highlight the critical need for innovative improvements to current prevention, diagnostic and treatment strategies available in resource poor settings, as well as the need for solutions that span multiple disciplines including food and water safety, sanitation and livestock production.

`Hard science': a career option for socially and societally interested students? Grade 12 students' vocational interest gap explored

Science.gov (United States)

Struyf, Annemie; Boeve-de Pauw, Jelle; Van Petegem, Peter

2017-11-01

A key theme in science education research concerns the decline in young peoples' interest in science and the need for professionals in hard science. Goal Congruity Theory posits that an important aspect of the decision whether to pursue hard science for study or as a career is the perception that hard science careers do not fulfil social (working with people) and societal (serving or helping others) interests. In this qualitative study, we explore grade 12 students' perceptions about the social and societal orientation of hard science careers. Furthermore, we investigate the variation in students' social and societal interests. Six focus groups were conducted with 58 grade 12 students in Flanders. Our results indicate that a number of students hold stereotypical views about hard science careers' social orientation, while others believe cooperation with others is an important aspect of hard science careers nowadays. Furthermore, our results show that students believe hard science careers can be societally oriented in the sense that they often associate them with innovation or societal progress. Finally, our results indicate that students may differentiate direct versus indirect societal orientation. These findings contribute to literature regarding social and societal interests and students' perceptions of hard science careers.

MaxAlign: maximizing usable data in an alignment

DEFF Research Database (Denmark)

Oliveira, Rodrigo Gouveia; Sackett, Peter Wad; Pedersen, Anders Gorm

2007-01-01

Align. In this paper we also introduce a new simple measure of tree similarity, Normalized Symmetric Similarity (NSS) that we consider useful for comparing tree topologies. CONCLUSION: We demonstrate how MaxAlign is helpful in detecting misaligned or defective sequences without requiring manual inspection. We also...

The how and why of societal publications for citizen science projects and scientists.

Science.gov (United States)

van Vliet, Arnold J H; Bron, Wichertje A; Mulder, Sara

2014-05-01

In the scientific community, the importance of communication to society is often underestimated. Scientists and scientific organisations often lack the skills to organise such communication effectively. The Dutch citizen science phenology network Nature's Calendar has been successful in communicating to the general public via numerous newspaper articles, television appearances, presentations, websites and social media. We refer to these publications as societal publications. Due to active communication to mass media, we frequently reach millions of people. This communication helped us to involve thousands of volunteers in recording the timing of phenological events like the start of flowering, leaf unfolding and bird migration, but also several health-related events like hay fever symptoms and tick bites. In this paper, we analyse and present our experiences with the Nature's Calendar project regarding societal publications. Based on this analysis, we explain the importance of societal publications for citizen science projects and scientists in general, and we show how scientists can increase the news worthiness of scientific information and what factors and activities can increase the chances of media paying attention to this news. We show that societal publications help phenological networks by facilitating the recruitment, retention and instruction of observers. Furthermore, they stimulate the generation of new ideas and partners that lead to an increase in knowledge, awareness and behavioural change of the general public or specific stakeholders. They make projects, and scientists involved, better known to the public and increase their credibility and authority. Societal publications can catalyse the production of new publications, thereby enforcing the previous mentioned points.

The how and why of societal publications for citizen science projects and scientists

Science.gov (United States)

van Vliet, Arnold J. H.; Bron, Wichertje A.; Mulder, Sara

2014-05-01

In the scientific community, the importance of communication to society is often underestimated. Scientists and scientific organisations often lack the skills to organise such communication effectively. The Dutch citizen science phenology network Nature's Calendar has been successful in communicating to the general public via numerous newspaper articles, television appearances, presentations, websites and social media. We refer to these publications as societal publications. Due to active communication to mass media, we frequently reach millions of people. This communication helped us to involve thousands of volunteers in recording the timing of phenological events like the start of flowering, leaf unfolding and bird migration, but also several health-related events like hay fever symptoms and tick bites. In this paper, we analyse and present our experiences with the Nature's Calendar project regarding societal publications. Based on this analysis, we explain the importance of societal publications for citizen science projects and scientists in general, and we show how scientists can increase the newsworthiness of scientific information and what factors and activities can increase the chances of media paying attention to this news. We show that societal publications help phenological networks by facilitating the recruitment, retention and instruction of observers. Furthermore, they stimulate the generation of new ideas and partners that lead to an increase in knowledge, awareness and behavioural change of the general public or specific stakeholders. They make projects, and scientists involved, better known to the public and increase their credibility and authority. Societal publications can catalyse the production of new publications, thereby enforcing the previous mentioned points.

'Compromise position' image alignment to accommodate independent motion of multiple clinical target volumes during radiotherapy: A high risk prostate cancer example.

Science.gov (United States)

Rosewall, Tara; Yan, Jing; Alasti, Hamideh; Cerase, Carla; Bayley, Andrew

2017-04-01

Inclusion of multiple independently moving clinical target volumes (CTVs) in the irradiated volume causes an image guidance conundrum. The purpose of this research was to use high risk prostate cancer as a clinical example to evaluate a 'compromise' image alignment strategy. The daily pre-treatment orthogonal EPI for 14 consecutive patients were included in this analysis. Image matching was performed by aligning to the prostate only, the bony pelvis only and using the 'compromise' strategy. Residual CTV surrogate displacements were quantified for each of the alignment strategies. Analysis of the 388 daily fractions indicated surrogate displacements were well-correlated in all directions (r 2  = 0.95 (LR), 0.67 (AP) and 0.59 (SI). Differences between the surrogates displacements (95% range) were -0.4 to 1.8 mm (LR), -1.2 to 5.2 mm (SI) and -1.2 to 5.2 mm (AP). The distribution of the residual displacements was significantly smaller using the 'compromise' strategy, compared to the other strategies (p 0.005). The 'compromise' strategy ensured the CTV was encompassed by the PTV in all fractions, compared to 47 PTV violations when aligned to prostate only. This study demonstrated the feasibility of a compromise position image guidance strategy to accommodate simultaneous displacements of two independently moving CTVs. Application of this strategy was facilitated by correlation between the CTV displacements and resulted in no geometric excursions of the CTVs beyond standard sized PTVs. This simple image guidance strategy may also be applicable to other disease sites that concurrently irradiate multiple CTVs, such as head and neck, lung and cervix cancer. © 2016 The Royal Australian and New Zealand College of Radiologists.

Societal megatrends and trends in vehicle technologies

OpenAIRE

Duysinx, Pierre

2018-01-01

The confrence enviions the future trends in automotive technologies at the light of societal megatrends. Different emerging technologies for the vehicle powertrain are envisionned for the next decade: piston engines with natural gas, battery electric vehicles, plug-in hybrid electric vehicles, fuel cells systems. In addition one must also consider the arrival of autonomous driving and of the race for lightweight design of cars.

Open Source Partner Strategy: Are Your Core Businesses Aligned?

Directory of Open Access Journals (Sweden)

Susan Riekki-Odle

2010-06-01

Full Text Available Technology companies have historically viewed partnerships through myopic, one-way lenses, asking only: "What can this partner do for me?" This type of thinking is even more pervasive with channel sales partnerships, where technology vendors limit the exploration of value to short term revenue contribution. Vendors must broaden their scope and range of site when embarking on a path of partnership strategy. Ecosystem analysis, economic modeling, and creative go-to-market development are critical components of successful partnership strategies. This article discusses this critical business strategy through a real world example and an overview of best practice.

Traditions and Transitions in Quantitative Societal Culture Research in Organization Studies

DEFF Research Database (Denmark)

Peterson, Mark, F.; Søndergaard, Mikael

2011-01-01

Quantitative societal culture research (QSCR) in organization studies crystallizes a configuration of social science perspectives and methods that became prominent in the 1970s. We consider the qualities of and boundaries around cultural groups that this tradition emphasizes, and other...... characteristics of cultural groups that it does not emphasize. Current debates surrounding this tradition reflect both recent social science innovations and rediscoveries of early social science perspectives. Our analysis of quantitative cross-cultural societal research in organization studies considers...... this process of crystallization, innovation and rediscovery. We suggest ways to address current controversies and promote conversations with other research approaches....

Control rod housing alignment

International Nuclear Information System (INIS)

Dixon, R.C.; Deaver, G.A.; Punches, J.R.; Singleton, G.E.; Erbes, J.G.; Offer, H.P.

1990-01-01

This patent describes a process for measuring the vertical alignment between a hole in a core plate and the top of a corresponding control rod drive housing within a boiling water reactor. It comprises: providing an alignment apparatus. The alignment apparatus including a lower end for fitting to the top of the control rod drive housing; an upper end for fitting to the aperture in the core plate, and a leveling means attached to the alignment apparatus to read out the difference in angularity with respect to gravity, and alignment pin registering means for registering to the alignment pin on the core plate; lowering the alignment device on a depending support through a lattice position in the top guide through the hole in the core plate down into registered contact with the top of the control rod drive housing; registering the upper end to the sides of the hole in the core plate; registering the alignment pin registering means to an alignment pin on the core plate to impart to the alignment device the required angularity; and reading out the angle of the control rod drive housing with respect to the hole in the core plate through the leveling devices whereby the angularity of the top of the control rod drive housing with respect to the hole in the core plate can be determined

Physical, Ecological, and Societal Indicators for the National Climate Assessment

Science.gov (United States)

Kenney, Melissa A.; Chen, Robert; Baptista, Sandra R.; Quattrochi, Dale; O'Brien, Sheila

2011-01-01

The National Climate Assessment (NCA) is being conducted under the auspices of the U.S. Global Change Research Program (USGCRP), pursuant to the Global Change Research Act of 1990, Section 106, which requires a report to Congress every 4 years. The current NCA (http://globalchange.gov/what-we-do/assessment/) differs in multiple ways from previous U.S. climate assessment efforts, being: (1) more focused on supporting the Nation s activities in adaptation and mitigation and on evaluating the current state of scientific knowledge relative to climate impacts and trends; (2) a long-term, consistent process for evaluation of climate risks and opportunities and providing information to support decision-making processes within regions and sectors; and (3) establishing a permanent assessment capacity both inside and outside of the federal government. As a part of ongoing, long-term assessment activities, the NCA intends to develop an integrated strategic framework and deploy climate-relevant physical, ecological, and societal indicators. The NCA indicators framework is underdevelopment by the NCA Development and Advisory Committee Indicators Working Group and are envisioned as a relatively small number of policy-relevant integrated indicators designed to provide a consistent, objective, and transparent overview of major variations in climate impacts, vulnerabilities, adaptation, and mitigation activities across sectors, regions, and timeframes. The potential questions that could be addressed by these indicators include: How do we know that there is a changing climate and how is it expected to change in the future? Are important climate impacts and opportunities occurring or predicted to occur in the future? Are we adapting successfully? What are the vulnerabilities and resiliencies given a changing climate? Are we preparing adequately for extreme events? It is not expected that the NCA societal indicators would be linked directly to a single decision or portfolio of

SATCHMO-JS: a webserver for simultaneous protein multiple sequence alignment and phylogenetic tree construction.

Science.gov (United States)

Hagopian, Raffi; Davidson, John R; Datta, Ruchira S; Samad, Bushra; Jarvis, Glen R; Sjölander, Kimmen

2010-07-01

We present the jump-start simultaneous alignment and tree construction using hidden Markov models (SATCHMO-JS) web server for simultaneous estimation of protein multiple sequence alignments (MSAs) and phylogenetic trees. The server takes as input a set of sequences in FASTA format, and outputs a phylogenetic tree and MSA; these can be viewed online or downloaded from the website. SATCHMO-JS is an extension of the SATCHMO algorithm, and employs a divide-and-conquer strategy to jump-start SATCHMO at a higher point in the phylogenetic tree, reducing the computational complexity of the progressive all-versus-all HMM-HMM scoring and alignment. Results on a benchmark dataset of 983 structurally aligned pairs from the PREFAB benchmark dataset show that SATCHMO-JS provides a statistically significant improvement in alignment accuracy over MUSCLE, Multiple Alignment using Fast Fourier Transform (MAFFT), ClustalW and the original SATCHMO algorithm. The SATCHMO-JS webserver is available at http://phylogenomics.berkeley.edu/satchmo-js. The datasets used in these experiments are available for download at http://phylogenomics.berkeley.edu/satchmo-js/supplementary/.

Exit-strategies

DEFF Research Database (Denmark)

Mørck, Line Lerche; Palm, Anne-Mette; Sys Møller-Andersen, Camilla

different empirical sources. To develop and extend an "exit-prototype" about conditions of importance for moving beyond a gang/criminal position, we have analyzed documents (from newspapers and books), involved ex-gang members, social workers and experts as co-researchers in interviews, "gang......This paper is about exit-strategies, constructing a theoretical and empirical informed analysis of current societal conditions that influence motor cycle gangs such as Hells Angels or Bandidos and other ‘wild' youth' possibilities and limitations for moving beyond criminal activities. We especially...... focus on the involved communities in the current Danish gang-conflict, which escalated with deadly killings in 2008, and thereby became a so called "gang-war". We will start out presenting different practice notions of exit, and we will extend and discuss understandings of "exit-strategies" by analyzing...

A Process Towards Societal Value within a Community-Based Regional Development Project

Directory of Open Access Journals (Sweden)

Anna Åslund

2012-12-01

Full Text Available Processes, activities and tasks of a community-based area development project are described. The main process has been used three times and a model is presented. An earlier developed process map has been verified. The description of the project can help other communities to plan development projects. The illustration can be valuable for entrepreneurs who are planning a societal value initiative and for decision-makers and stakeholders who can contribute to, are concerned with, or may be affected by societal entrepreneurship. Observation, participating studies, dokumentations and an interview with the project leader has been carried out. Data have been analyzed and compared with the previously developed process map to achieve a deeper understanding of the processes within societal entrepreneurship. The purpose was to study and describe the processes of a community-based area development project and to compare it with a previously developed process map and to verify the process map.

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G. Gomez

2012-01-01

  A new muon alignment has been produced for 2012 A+B data reconstruction. It uses the latest Tracker alignment and single-muon data samples to align both DTs and CSCs. Physics validation has been performed and shows a modest improvement in stand-alone muon momentum resolution in the barrel, where the alignment is essentially unchanged from the previous version. The reference-target track-based algorithm using only collision muons is employed for the first time to align the CSCs, and a substantial improvement in resolution is observed in the endcap and overlap regions for stand-alone muons. This new alignment is undergoing the approval process and is expected to be deployed as part of a new global tag in the beginning of December. The pT dependence of the φ-bias in curvature observed in Monte Carlo was traced to a relative vertical misalignment between the Tracker and barrel muon systems. Moving the barrel as a whole to match the Tracker cures this pT dependence, leaving only the &phi...

Simulation of beamline alignment operations

International Nuclear Information System (INIS)

Annese, C; Miller, M G.

1999-01-01

The CORBA-based Simulator was a Laboratory Directed Research and Development (LDRD) project that applied simulation techniques to explore critical questions about distributed control systems. The simulator project used a three-prong approach that studied object-oriented distribution tools, computer network modeling, and simulation of key control system scenarios. The National Ignition Facility's (NIF) optical alignment system was modeled to study control system operations. The alignment of NIF's 192 beamlines is a large complex operation involving more than 100 computer systems and 8000 mechanized devices. The alignment process is defined by a detailed set of procedures; however, many of the steps are deterministic. The alignment steps for a poorly aligned component are similar to that of a nearly aligned component; however, additional operations/iterations are required to complete the process. Thus, the same alignment operations will require variable amounts of time to perform depending on the current alignment condition as well as other factors. Simulation of the alignment process is necessary to understand beamline alignment time requirements and how shared resources such as the Output Sensor and Target Alignment Sensor effect alignment efficiency. The simulation has provided alignment time estimates and other results based on documented alignment procedures and alignment experience gained in the laboratory. Computer communication time, mechanical hardware actuation times, image processing algorithm execution times, etc. have been experimentally determined and incorporated into the model. Previous analysis of alignment operations utilized average implementation times for all alignment operations. Resource sharing becomes rather simple to model when only average values are used. The time required to actually implement the many individual alignment operations will be quite dynamic. The simulation model estimates the time to complete an operation using

CAB-Align: A Flexible Protein Structure Alignment Method Based on the Residue-Residue Contact Area.

Directory of Open Access Journals (Sweden)

Genki Terashi

Full Text Available Proteins are flexible, and this flexibility has an essential functional role. Flexibility can be observed in loop regions, rearrangements between secondary structure elements, and conformational changes between entire domains. However, most protein structure alignment methods treat protein structures as rigid bodies. Thus, these methods fail to identify the equivalences of residue pairs in regions with flexibility. In this study, we considered that the evolutionary relationship between proteins corresponds directly to the residue-residue physical contacts rather than the three-dimensional (3D coordinates of proteins. Thus, we developed a new protein structure alignment method, contact area-based alignment (CAB-align, which uses the residue-residue contact area to identify regions of similarity. The main purpose of CAB-align is to identify homologous relationships at the residue level between related protein structures. The CAB-align procedure comprises two main steps: First, a rigid-body alignment method based on local and global 3D structure superposition is employed to generate a sufficient number of initial alignments. Then, iterative dynamic programming is executed to find the optimal alignment. We evaluated the performance and advantages of CAB-align based on four main points: (1 agreement with the gold standard alignment, (2 alignment quality based on an evolutionary relationship without 3D coordinate superposition, (3 consistency of the multiple alignments, and (4 classification agreement with the gold standard classification. Comparisons of CAB-align with other state-of-the-art protein structure alignment methods (TM-align, FATCAT, and DaliLite using our benchmark dataset showed that CAB-align performed robustly in obtaining high-quality alignments and generating consistent multiple alignments with high coverage and accuracy rates, and it performed extremely well when discriminating between homologous and nonhomologous pairs of proteins

CAB-Align: A Flexible Protein Structure Alignment Method Based on the Residue-Residue Contact Area.

Science.gov (United States)

Terashi, Genki; Takeda-Shitaka, Mayuko

2015-01-01

Proteins are flexible, and this flexibility has an essential functional role. Flexibility can be observed in loop regions, rearrangements between secondary structure elements, and conformational changes between entire domains. However, most protein structure alignment methods treat protein structures as rigid bodies. Thus, these methods fail to identify the equivalences of residue pairs in regions with flexibility. In this study, we considered that the evolutionary relationship between proteins corresponds directly to the residue-residue physical contacts rather than the three-dimensional (3D) coordinates of proteins. Thus, we developed a new protein structure alignment method, contact area-based alignment (CAB-align), which uses the residue-residue contact area to identify regions of similarity. The main purpose of CAB-align is to identify homologous relationships at the residue level between related protein structures. The CAB-align procedure comprises two main steps: First, a rigid-body alignment method based on local and global 3D structure superposition is employed to generate a sufficient number of initial alignments. Then, iterative dynamic programming is executed to find the optimal alignment. We evaluated the performance and advantages of CAB-align based on four main points: (1) agreement with the gold standard alignment, (2) alignment quality based on an evolutionary relationship without 3D coordinate superposition, (3) consistency of the multiple alignments, and (4) classification agreement with the gold standard classification. Comparisons of CAB-align with other state-of-the-art protein structure alignment methods (TM-align, FATCAT, and DaliLite) using our benchmark dataset showed that CAB-align performed robustly in obtaining high-quality alignments and generating consistent multiple alignments with high coverage and accuracy rates, and it performed extremely well when discriminating between homologous and nonhomologous pairs of proteins in both

BinAligner: a heuristic method to align biological networks.

Science.gov (United States)

Yang, Jialiang; Li, Jun; Grünewald, Stefan; Wan, Xiu-Feng

2013-01-01

The advances in high throughput omics technologies have made it possible to characterize molecular interactions within and across various species. Alignments and comparison of molecular networks across species will help detect orthologs and conserved functional modules and provide insights on the evolutionary relationships of the compared species. However, such analyses are not trivial due to the complexity of network and high computational cost. Here we develop a mixture of global and local algorithm, BinAligner, for network alignments. Based on the hypotheses that the similarity between two vertices across networks would be context dependent and that the information from the edges and the structures of subnetworks can be more informative than vertices alone, two scoring schema, 1-neighborhood subnetwork and graphlet, were introduced to derive the scoring matrices between networks, besides the commonly used scoring scheme from vertices. Then the alignment problem is formulated as an assignment problem, which is solved by the combinatorial optimization algorithm, such as the Hungarian method. The proposed algorithm was applied and validated in aligning the protein-protein interaction network of Kaposi's sarcoma associated herpesvirus (KSHV) and that of varicella zoster virus (VZV). Interestingly, we identified several putative functional orthologous proteins with similar functions but very low sequence similarity between the two viruses. For example, KSHV open reading frame 56 (ORF56) and VZV ORF55 are helicase-primase subunits with sequence identity 14.6%, and KSHV ORF75 and VZV ORF44 are tegument proteins with sequence identity 15.3%. These functional pairs can not be identified if one restricts the alignment into orthologous protein pairs. In addition, BinAligner identified a conserved pathway between two viruses, which consists of 7 orthologous protein pairs and these proteins are connected by conserved links. This pathway might be crucial for virus packing and

Prediction of molecular alignment of nucleic acids in aligned media

International Nuclear Information System (INIS)

Wu Bin; Petersen, Michael; Girard, Frederic; Tessari, Marco; Wijmenga, Sybren S.

2006-01-01

We demonstrate - using the data base of all deposited DNA and RNA structures aligned in Pf1-medium and RDC refined - that for nucleic acids in a Pf1-medium the electrostatic alignment tensor can be predicted reliably and accurately via a simple and fast calculation based on the gyration tensor spanned out by the phosphodiester atoms. The rhombicity is well predicted over its full range from 0 to 0.66, while the alignment tensor orientation is predicted correctly for rhombicities up to ca. 0.4, for larger rhombicities it appears to deviate somewhat more than expected based on structural noise and measurement error. This simple analytical approach is based on the Debye-Huckel approximation for the electrostatic interaction potential, valid at distances sufficiently far away from a poly-ionic charged surface, a condition naturally enforced when the charge of alignment medium and solute are of equal sign, as for nucleic acids in a Pf1-phage medium. For the usual salt strengths and nucleic acid sizes, the Debye-Huckel screening length is smaller than the nucleic acid size, but large enough for the collective of Debye-Huckel spheres to encompass the whole molecule. The molecular alignment is then purely electrostatic, but it's functional form is under these conditions similar to that for steric alignment. The proposed analytical expression allows for very fast calculation of the alignment tensor and hence RDCs from the conformation of the nucleic acid molecule. This information provides opportunities for improved structure determination of nucleic acids, including better assessment of dynamics in (multi-domain) nucleic acids and the possibility to incorporate alignment tensor prediction from shape directly into the structure calculation process. The procedures are incorporated into MATLAB scripts, which are available on request

A new prosthetic alignment device to read and record prosthesis alignment data.

Science.gov (United States)

Pirouzi, Gholamhossein; Abu Osman, Noor Azuan; Ali, Sadeeq; Davoodi Makinejad, Majid

2017-12-01

Prosthetic alignment is an essential process to rehabilitate patients with amputations. This study presents, for the first time, an invented device to read and record prosthesis alignment data. The digital device consists of seven main parts: the trigger, internal shaft, shell, sensor adjustment button, digital display, sliding shell, and tip. The alignment data were read and recorded by the user or a computer to replicate prosthesis adjustment for future use or examine the sequence of changes in alignment and its effect on the posture of the patient. Alignment data were recorded at the anterior/posterior and medial/lateral positions for five patients. Results show the high level of confidence to record alignment data and replicate adjustments. Therefore, the device helps patients readjust their prosthesis by themselves, or prosthetists to perform adjustment for patients and analyze the effects of malalignment.

Societal learning in epidemics: intervention effectiveness during the 2003 SARS outbreak in Singapore.

Directory of Open Access Journals (Sweden)

John M Drake

Full Text Available BACKGROUND: Rapid response to outbreaks of emerging infectious diseases is impeded by uncertain diagnoses and delayed communication. Understanding the effect of inefficient response is a potentially important contribution of epidemic theory. To develop this understanding we studied societal learning during emerging outbreaks wherein patient removal accelerates as information is gathered and disseminated. METHODS AND FINDINGS: We developed an extension of a standard outbreak model, the simple stochastic epidemic, which accounts for societal learning. We obtained expressions for the expected outbreak size and the distribution of epidemic duration. We found that rapid learning noticeably affects the final outbreak size even when learning exhibits diminishing returns (relaxation. As an example, we estimated the learning rate for the 2003 outbreak of severe acute respiratory syndrome (SARS in Singapore. Evidence for relaxation during the first eight weeks of the outbreak was inconclusive. We estimated that if societal learning had occurred at half the actual rate, the expected final size of the outbreak would have reached nearly 800 cases, more than three times the observed number of infections. By contrast, the expected outbreak size for societal learning twice as effective was 116 cases. CONCLUSION: These results show that the rate of societal learning can greatly affect the final size of disease outbreaks, justifying investment in early warning systems and attentiveness to disease outbreak by both government authorities and the public. We submit that the burden of emerging infections, including the risk of a global pandemic, could be efficiently reduced by improving procedures for rapid detection of outbreaks, alerting public health officials, and aggressively educating the public at the start of an outbreak.

Access. Challenge for Change/Societe Nouvelle Number Eleven.

Science.gov (United States)

Prinn, Elizabeth, Ed.

Access is a journal published three or four times a year by Challenge for Change/Societe Nouvelle (CCSN). CCSN is an experimental program established by the Government of Canada as a cooperative effort between the National Film Board of Canada and certain of the Government's departments. Its purposes are to improve communications, create greater…

Impacts of National Decarbonization Targets for Subnational Societal Priorities

Science.gov (United States)

Peng, W.; Iyer, G.

2017-12-01

Carbon mitigation has well-recognized linkages with other environmental and socioeconomic priorities, such as air pollution, economic development, employment, etc. While climate change is a global issue, many other societal priorities are local concerns. Since local efforts form the pillars of achieving co-benefits and avoiding dis-benefits at the national level, it is critical to go beyond national-level analyses and focus on the synergies and tradeoffs at the subnational level. Here we use the United States as an example to evaluate the impacts of mid-century national-level deep decarbonization target for state-level societal priorities. Based on the Global Change Assessment Model with state-level details for the US (GCAM-USA), we design two mid-century scenarios: A Reference scenario that assumes the U.S. undertakes no additional climate mitigation policy, and a Deep Decarbonization Scenario that assumes the U.S. achieves the NDC goal through 2025 (26-28% reduction relative to 2005 levels) and then follows a straight-line trajectory to 80% reductions in economy-wide GHG emissions by 2050 relative to 2005. We then compare these two scenarios for a variety of metrics of carbon mitigation and other societal priorities in 2050. We highlight two findings. First, the synergies and tradeoffs of carbon mitigation with other societal goals at the subnational level can be quite different from the national level. For example, while deep decarbonization could improve national energy security by reducing the overall dependence on energy imports, it may exacerbate energy independence goals for some states by increasing inter-state electricity imports. Second, achieving national-level decarbonization target could result in unequal regional impacts across states. We find uneven geographic impacts for air pollution (more co-reductions occur in the eastern states), economic costs (energy prices increase more in the northeastern states) and employment (jobs increase in the western

Aligning the systems of environmental accounting: From EU to Stockholm and vice versa

Energy Technology Data Exchange (ETDEWEB)

Burstroem, F.; Frostell, B. [Royal Inst. of Technology, Stockholm (Sweden). Dept. of Environmental Technology and Work Science

2001-07-01

During the last decade, authorities in local and regional communities, nations and international governance organisations, like the European Union (EU), have developed several systems for environmental accounting. An important issue in this development is the collection and collation of data. Except for the question of what data to collect, there is also a question of how to collect data. Focusing in particular on developments of physical environmental accounting systems in Sweden, a member nation of the EU, and drawing from experiences from work with materials accounting in the City of Stockholm, this paper discusses the need to align environmental accounting systems of different societal levels. It is argued that the systems of collecting 'environmental' data have to be better aligned with the objectives and strategies of environmental management and policy making, taking into account all aspects of utilisation of the basic data to be collected. If not, the result will be a conservation of the fragmented point solutions of environmental accounting systems we face today, resulting in inconsistency of data, duplication of data collection and processing efforts, and inflexibility to deal with changes. From this, it is also argued that the collection of data for physical environmental accounting (i.e. data on flows and stocks of materials and substances in society and the environment), would preferably be performed by a local/regional authority, but co-ordinated by national authorities and a national statistical office, under supervision of international authorities and statistical offices. Finally, the paper presents a structural framework for regional materials accounting, which combines a product-oriented strand with a substance-oriented strand of materials accounting, and allows for accounting and analysis on different levels of aggregation. This framework, which has been developed in co-operation with the City of Stockholm, should mainly be considered

Effects of variable attachment shapes and aligner material on aligner retention.

Science.gov (United States)

Dasy, Hiltrud; Dasy, Andreas; Asatrian, Greg; Rózsa, Noémi; Lee, Hao-Fu; Kwak, Jin Hee

2015-11-01

To evaluate the retention of four types of aligners on a dental arch with various attachments. For this study, three casts were manufactured, two of which contained attachments (ellipsoid and beveled), and one without any attachments to serve as a control. Four types of aligners were thermoformed: Clear-Aligner (CA)-soft, CA-medium, and CA-hard, with various thicknesses, and Essix ACE. Measurements of vertical displacement force during aligner removal were performed with the Gabo Qualimeter Eplexor. Means and standard deviations were next compared between different aligner thicknesses and attachment shapes. CA-soft, CA-medium, and CA-hard did not present a significant increase in retention, except when used in the presence of attachments. Additionally, CA-medium and CA-hard required significantly more force for removal. Essix ACE demonstrated a significant decrease in retention when used with ellipsoid attachments. The force value for Essix ACE removal from the cast with beveled attachments was comparable to that of CA-medium. Forces for aligner removal from the model without attachments showed a linear trend. Essix ACE did not show a continuous increase in retention for each model. Overall, ellipsoid attachments did not present a significant change in retention. In contrast, beveled attachments improved retention. Ellipsoid attachments had no significant influence on the force required for aligner removal and hence on aligner retention. Essix ACE showed significantly less retention than CA-hard on the models with attachments. Furthermore, beveled attachments were observed to increase retention significantly, compared with ellipsoid attachments and when using no attachments.

Vertically aligned single-walled carbon nanotubes by chemical assembly--methodology, properties, and applications.

Science.gov (United States)

Diao, Peng; Liu, Zhongfan

2010-04-06

Single-walled carbon nanotubes (SWNTs), as one of the most promising one-dimension nanomaterials due to its unique structure, peculiar chemical, mechanical, thermal, and electronic properties, have long been considered as an important building block to construct ordered alignments. Vertically aligned SWNTs (v-SWNTs) have been successfully prepared by using direct growth and chemical assembly strategies. In this review, we focus explicitly on the v-SWNTs fabricated via chemical assembly strategy. We provide the readers with a full and systematic summary covering the advances in all aspects of this area, including various approaches for the preparation of v-SWNTs using chemical assembly techniques, characterization, assembly kinetics, and electrochemical properties of v-SWNTs. We also review the applications of v-SWNTs in electrochemical and bioelectrochemical sensors, photoelectric conversion, and scanning probe microscopy.

Coping with Complex Environmental and Societal Flood Risk Management Decisions: An Integrated Multi-criteria Framework

Directory of Open Access Journals (Sweden)

Love Ekenberg

2011-08-01

Full Text Available During recent years, a great deal of attention has been focused on the financial risk management of natural disasters. One reason behind is that the economic losses from floods, windstorms, earthquakes and other disasters in both the developing and developed countries are escalating dramatically. It has become apparent that an integrated water resource management approach would be beneficial in order to take both the best interests of society and of the environment into consideration. One improvement consists of models capable of handling multiple criteria (conflicting objectives as well as multiple stakeholders (conflicting interests. A systems approach is applied for coping with complex environmental and societal risk management decisions with respect to flood catastrophe policy formation, wherein the emphasis is on computer-based modeling and simulation techniques combined with methods for evaluating strategies where numerous stakeholders are incorporated in the process. The resulting framework consists of a simulation model, a decision analytical tool, and a set of suggested policy strategies for policy formulation. The framework will aid decision makers with high risk complex environmental decisions subject to significant uncertainties.

Alignment Effectiveness for Value Creation with Information Systems

Directory of Open Access Journals (Sweden)

Martina MITAMBO

2014-08-01

Full Text Available Enterprises often face problems while executing business strategies to exploit opportunities or solve problems. Within enterprises, strategy blindness could be affected by mistranslation of strategic intent, flexibility of the information system, or cognitive entrenchment. The alignment between business strategy and business processes is a critical factor in the ability of enterprises to overcome the phenomenon. Opportunities for value creation include magnifying the positive spread in cash flow or pursuing growth opportunities. Information systems could greatly simplify the processes involved in business strategy by integrating process-related decision-making with the business strategy. Decision support tools such as knowledge management, decision strategy, decision content, and expert groups, customised for organisational information systems can help enterprises optimise operations in a variety of ways such as becoming more responsive to changing market conditions in hypercompetitive markets. Greatest opportunities for decision support are incorporating external sources of data such as economic data and user behaviour analytics. Benefits are more effective utilisation of resources, larger product portfolio, better product or service quality, and shorter delivery times.

On the societal nature of praxis and organic research

Science.gov (United States)

Roth, Wolff-Michael

2016-03-01

In its focus on social practices, the feature article presents an interesting theoretical framework for rethinking not only where and how knowing and learning in science education exhibit themselves but also we might change our own research practice. The framework is not new to me, as I have advocated it explicitly for more than 15 years. But over time it became apparent to me that some particularities of participation in practice may be grounded more strongly in an orientation towards the societal nature of any human praxis. In this forum contribution, I present a theoretical approach built on societal-historical activity theory that also takes activism as a major category for theorizing participation. This approach not only covers the extent of the social practice framework but also allows us to make thematic the production of inequity and restrictions to access science and engineering that are characteristic of many societies.

Evolution of the societal value of water resources for economic development versus environmental sustainability in Australia from 1843 to 2011

Science.gov (United States)

Wei, Y.; Wei, J., , Dr; Western, A. W.

2017-12-01

The scale of human activity in the last 200 years has reached a point where our actions are affecting the global biophysical environment to such a degree and at such a speed that irreversible effects are being observed. Societal values are generally seen as leading to changes in human decisions and actions, but have not been addressed adequately in current water management, which is blind to changes in the social drivers for, or societal responses to, management decisions. This paper describes the evolution of societal value of water resources in Australia over a period of 169 years. These values were classified into two groups: supporting economic development versus supporting environmental sustainability. The Sydney Morning Herald newspaper was used as the main data source to track the changes in the societal value of water resources. Content analysis was used to create a description of the evolution of these societal values. Mathematical regression analysis, in combination of transition theory, was used to determine the stages of transition of the societal value, and the co-evolved social-ecological framework was used to explain how the evolution of societal values interacted with water management policies/practices and droughts. Key findings included that the transition of the societal value of water resources fitted the sigmoid curve - a conceptual S curve for the transition of social systems. Also, the transition of societal value of water resources in Australia went through three stages: (1) pre-development (1900s-1960s), when the societal value of water resources was dominated by economic development; (2) take-off (1962-1980), when the societal value of water resources reflected the increasing awareness of the environment due to the outbreak of pollution events; (3) acceleration (1981-2011), when the environment-oriented societal value of water resources combined with the Millennium Drought to trigger a package of policy initiatives and management practices

Individual and societal consequences of hypoglycemia

DEFF Research Database (Denmark)

Dømgaard, Mikala; Bagger, Malene; Rhee, Nicolai Alexander

2015-01-01

BACKGROUND: Hypoglycemia and fear of hypoglycemia threaten individuals' ability to work and drive. We studied the effect of hypoglycemia on the individual and society, with a focus on possible implications of new European union legislation on patients' continued ability to drive. METHODS: A cross......-sectional survey of Danish Diabetes Association members was conducted to investigate individual and societal consequences of hypoglycemia. RESULTS: A total of 3117/9951 individuals with type 1 diabetes (T1DM) (32.2%) or type 2 diabetes (T2DM) (67.8%) completed the survey. The calculated incidence rates of self...

Integrating Socioeconomic Data into GEOSS to Enable Societal Benefits

Science.gov (United States)

Chen, R. S.; Yetman, G.

2009-12-01

Achieving the GEOSS vision of societal benefits from Earth observation data is a multi-faceted challenge. Linking Earth observation systems into an interoperable system of systems is an important first step, but not sufficient on its own to fulfill the ambitious GEOSS goal of improving decision making for disaster mitigation, public health, ecosystem and resource management, agriculture, and the other societal benefit areas. Significant attention needs to be given to interdisciplinary data integration, especially with regard to incorporating data and information on human activities and welfare into monitoring, modeling, and prediction activities. For example, the ability to assess, monitor, and predict the risks posed by different natural hazards is predicated on an understanding of the underlying exposure and vulnerability of different human populations and their economic assets to past, present, and future hazardous events. The NASA Socioeconomic Data and Applications Center (SEDAC) has pioneered the integration of socioeconomic data with remote sensing data within the NASA Earth Observing System Data and Information System (EOSDIS) and has contributed actively to both phase 1 and 2 of the GEOSS Architecture Implementation Pilot. We present here several use cases for socioeconomic data integration in GEOSS and recent experience in developing an interoperable Web Processing Service (WPS) for estimating population exposure as part of the GEOSS initial operating capability. We also discuss key scientific, technical, and policy challenges to developing GEOSS products and services that will be able to meet the needs of both interdisciplinary and applied users and in so doing help achieve the GEOSS goal of generating significant societal benefits.

Strategies towards Evaluation beyond Scientific Impact. Pathways not only for Agricultural Research

Directory of Open Access Journals (Sweden)

Birge M. Wolf

2013-12-01

Full Text Available Various research fields, like organic agricultural research, are dedicated to solving real-world problems and contributing to sustainable development. Therefore, systems research and the application of interdisciplinary and transdisciplinary approaches are increasingly endorsed. However, research performance depends not only on self-conception, but also on framework conditions of the scientific system, which are not always of benefit to such research fields. Recently, science and its framework conditions have been under increasing scrutiny as regards their ability to serve societal benefit. This provides opportunities for (organic agricultural research to engage in the development of a research system that will serve its needs. This article focuses on possible strategies for facilitating a balanced research evaluation that recognises scientific quality as well as societal relevance and applicability. These strategies are (a to strengthen the general support for evaluation beyond scientific impact, and (b to provide accessible data for such evaluations. Synergies of interest are found between open access movements and research communities focusing on global challenges and sustainability. As both are committed to increasing the societal benefit of science, they may support evaluation criteria such as knowledge production and dissemination tailored to societal needs, and the use of open access. Additional synergies exist between all those who scrutinise current research evaluation systems for their ability to serve scientific quality, which is also a precondition for societal benefit. Here, digital communication technologies provide opportunities to increase effectiveness, transparency, fairness and plurality in the dissemination of scientific results, quality assurance and reputation. Furthermore, funders may support transdisciplinary approaches and open access and improve data availability for evaluation beyond scientific impact. If they begin to

Mask alignment system for semiconductor processing

Science.gov (United States)

Webb, Aaron P.; Carlson, Charles T.; Weaver, William T.; Grant, Christopher N.

2017-02-14

A mask alignment system for providing precise and repeatable alignment between ion implantation masks and workpieces. The system includes a mask frame having a plurality of ion implantation masks loosely connected thereto. The mask frame is provided with a plurality of frame alignment cavities, and each mask is provided with a plurality of mask alignment cavities. The system further includes a platen for holding workpieces. The platen may be provided with a plurality of mask alignment pins and frame alignment pins configured to engage the mask alignment cavities and frame alignment cavities, respectively. The mask frame can be lowered onto the platen, with the frame alignment cavities moving into registration with the frame alignment pins to provide rough alignment between the masks and workpieces. The mask alignment cavities are then moved into registration with the mask alignment pins, thereby shifting each individual mask into precise alignment with a respective workpiece.

Access. Challenge for Change/Societe Nouvelle Number Twelve.

Science.gov (United States)

Prinn, Elizabeth, Ed.; Henaut, Dorothy Todd, Ed.

This issue of Access, the journal issued periodically by Challenge for Change/Societe Nouvelle, contains two groups of articles. The first focuses upon the Skyriver Project, relating how a project was developed which used film and video tape as a means of helping Alaskan communities to assess their own needs and to advocate for themselves the…

Aligning the Culture and Strategy for Success

Science.gov (United States)

Tosti, Donald T.

2007-01-01

One way to define culture is "the way a group of people prefer to behave." The trick for organizational leaders is to find ways to ensure that the company culture, that is the way their people prefer to behave, is supportive of what is needed to successfully deliver the company strategy. Using a criteron-referenced approach, we can first examine…

Corruption, Politics and Societal values in Tanzania: An evaluation ...

African Journals Online (AJOL)

Corruption, Politics and Societal values in Tanzania: An evaluation of the Mkapa administration's anti corruption efforts. Bruce Heilman, Lawrean Ndumbaro. Abstract. (Af. J. Political Science: 2001 7(1): 1-20). Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

How, when, and for what reasons does land use modelling contribute to societal problem solving?

NARCIS (Netherlands)

Sterk, B.; Ittersum, van M.K.; Leeuwis, C.

2011-01-01

This paper reports and reflects on the contributions of land use models to societal problem solving. Its purpose is to inform model development and application and thus to increase chances for societal benefit of the modelling work. The key question is: How, when, and for what reasons does land use

Undergraduate Climate Education: Motivations, Strategies, Successes, and Support

Science.gov (United States)

Kirk, Karin B.; Gold, Anne U.; Ledley, Tamara Shapiro; Sullivan, Susan Buhr; Manduca, Cathryn A.; Mogk, David W.; Wiese, Katryn

2014-01-01

Climate literacy is an essential component of a strategy to comprehend and confront the grand challenge of global climate change. However, scientific complexity, societal implications, and political associations make climate change a difficult but important topic to teach. In this paper we report on the results of a survey of undergraduate faculty…

Assessing the impact on chronic disease of incorporating the societal cost of greenhouse gases into the price of food: an econometric and comparative risk assessment modelling study.

Science.gov (United States)

Briggs, Adam D M; Kehlbacher, Ariane; Tiffin, Richard; Garnett, Tara; Rayner, Mike; Scarborough, Peter

2013-10-22

To model the impact on chronic disease of a tax on UK food and drink that internalises the wider costs to society of greenhouse gas (GHG) emissions and to estimate the potential revenue. An econometric and comparative risk assessment modelling study. The UK. The UK adult population. Two tax scenarios are modelled: (A) a tax of £2.72/tonne carbon dioxide equivalents (tCO2e)/100 g product applied to all food and drink groups with above average GHG emissions. (B) As with scenario (A) but food groups with emissions below average are subsidised to create a tax neutral scenario. Primary outcomes are change in UK population mortality from chronic diseases following the implementation of each taxation strategy, the change in the UK GHG emissions and the predicted revenue. Secondary outcomes are the changes to the micronutrient composition of the UK diet. Scenario (A) results in 7770 (95% credible intervals 7150 to 8390) deaths averted and a reduction in GHG emissions of 18 683 (14 665to 22 889) ktCO2e/year. Estimated annual revenue is £2.02 (£1.98 to £2.06) billion. Scenario (B) results in 2685 (1966 to 3402) extra deaths and a reduction in GHG emissions of 15 228 (11 245to 19 492) ktCO2e/year. Incorporating the societal cost of GHG into the price of foods could save 7770 lives in the UK each year, reduce food-related GHG emissions and generate substantial tax revenue. The revenue neutral scenario (B) demonstrates that sustainability and health goals are not always aligned. Future work should focus on investigating the health impact by population subgroup and on designing fiscal strategies to promote both sustainable and healthy diets.

MUON DETECTORS: ALIGNMENT

CERN Multimedia

M. Dallavalle

2013-01-01

A new Muon misalignment scenario for 2011 (7 TeV) Monte Carlo re-processing was re-leased. The scenario is based on running of standard track-based reference-target algorithm (exactly as in data) using single-muon simulated sample (with the transverse-momentum spectrum matching data). It used statistics similar to what was used for alignment with 2011 data, starting from an initially misaligned Muon geometry from uncertainties of hardware measurements and using the latest Tracker misalignment geometry. Validation of the scenario (with muons from Z decay and high-pT simulated muons) shows that it describes data well. The study of systematic uncertainties (dominant by now due to huge amount of data collected by CMS and used for muon alignment) is finalised. Realistic alignment position errors are being obtained from the estimated uncertainties and are expected to improve the muon reconstruction performance. Concerning the Hardware Alignment System, the upgrade of the Barrel Alignment is in progress. By now, d...

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G. Gomez

2011-01-01

A new set of muon alignment constants was approved in August. The relative position between muon chambers is essentially unchanged, indicating good detector stability. The main changes concern the global positioning of the barrel and of the endcap rings to match the new Tracker geometry. Detailed studies of the differences between track-based and optical alignment of DTs have proven to be a valuable tool for constraining Tracker alignment weak modes, and this information is now being used as part of the alignment procedure. In addition to the “split-cosmic” analysis used to investigate the muon momentum resolution at high momentum, a new procedure based on reconstructing the invariant mass of di-muons from boosted Zs is under development. Both procedures show an improvement in the momentum precision of Global Muons with respect to Tracker-only Muons. Recent developments in track-based alignment include a better treatment of the tails of residual distributions and accounting for correla...

Risk assessment and societal choices

Energy Technology Data Exchange (ETDEWEB)

Otway, H J

1975-02-15

Many countries are experiencing a period in which traditional values are being questioned; plans for further technological progress are being met by a variety of demands for a closer examination of the benefits and risks of large-scale technologies. In this paper the concepts of risk assessment are presented and a model is proposed which illustrates the importance of socio-psychological mechanisms in the acceptance of technological risks. The research plan of the Joint IAEA/IIASA Research Project is outlined: this work is directed toward gaining an improved understanding of how societies judge the acceptability of technologies and how societal attitudes and anticipated responses may be better integrated into the decision-making process. Some preliminary results are reported. (author)

Risk assessment and societal choices

International Nuclear Information System (INIS)

Otway, H.J.

1975-01-01

Many countries are experiencing a period in which traditional values are being questioned; plans for further technological progress are being met by a variety of demands for a closer examination of the benefits and risks of large-scale technologies. In this paper the concepts of risk assessment are presented and a model is proposed which illustrates the importance of socio-psychological mechanisms in the acceptance of technological risks. The research plan of the Joint IAEA/IIASA Research Project is outlined: this work is directed toward gaining an improved understanding of how societies judge the acceptability of technologies and how societal attitudes and anticipated responses may be better integrated into the decision-making process. Some preliminary results are reported. (author)

The societal cost of heroin use disorder in the United States.

Directory of Open Access Journals (Sweden)

Ruixuan Jiang

Full Text Available Heroin use in the United States has reached epidemic proportions. The objective of this paper is to estimate the annual societal cost of heroin use disorder in the United States in 2015 US dollars.An analytic model was created that included incarceration and crime; treatment for heroin use disorder; chronic infectious diseases (HIV, Hepatitis B, Hepatitis C, and Tuberculosis and their treatments; treatment of neonatal abstinence syndrome; lost productivity; and death by heroin overdose.Using literature-based estimates to populate the model, the cost of heroin use disorder was estimated to be $51.2 billion in 2015 US dollars ($50,799 per heroin user. One-way sensitivity analyses showed that overall cost estimates were sensitive to the number of heroin users, cost of HCV treatment, and cost of incarcerating heroin users.The annual cost of heroin use disorder to society in the United States emphasizes the need for sustained investment in healthcare and non-healthcare related strategies that reduce the likelihood of abuse and provide care and support for users to overcome the disorder.

Low-literates’ support needs for societal participation learning : Empirical grounding of theory- and model-based design

NARCIS (Netherlands)

Schouten, D.G.M.; Paulissen, R.T.; Hanekamp, M.; Groot, A.; Neerincx, M.A.; Cremers, A.H.M.

2017-01-01

Specialized learning support software can address the low societal participation of low-literate Dutch citizens. We use the situated Cognitive Engineering method to iteratively create a design specification for the envisioned system VESSEL: a Virtual Environment to Support the Societal participation

Is the societal burden of fatal occupational injury different among NORA industry sectors?

Science.gov (United States)

Biddle, Elyce Anne

2013-02-01

Since the implementation of the Occupational Safety and Health Act, safety and health in the work environment has seen marked improvement. Although these improvements are laudable, workplace hazards continue to plague the American worker. Understanding the economic burden of fatalities by industry sector is important to setting broad occupational safety and health research priorities. Cost estimates provide additional information about how fatal injuries affect society and hence can improve injury prevention program planning, policy analysis, evaluation, and advocacy. This study estimated the total, mean, and median societal costs by worker and case characteristic in 2003-2006 for the industry sectors identified in the National Institute for Occupational Safety and Health National Occupational Research Agenda (NORA). Analyses were conducted with restricted access to the Bureau of Labor Statistics Census of Fatal Occupational Injuries data. These data exclude military personnel, decedents with unknown age or sex, and fatalities occurring in New York City. Societal costs were estimated using the cost-of-illness approach, which combines direct and indirect costs to yield an overall cost of an fatal occupational injury. During this period, the cost of the 22,197 fatal occupational injuries exceeded $21 billion. The mean and median costs of these fatalities were $960,000 and $944,000 respectively. Total societal costs by NORA sector ranged from a high of $5.8 billion in Services to a low of $530 million in Healthcare and Social Assistance with mean costs ranging from the nearly $800,000 in Agriculture, Forestry, and Fishing to almost $1.1 million in Mining. The societal costs-total, mean, and median costs-of case and worker characteristics for occupational fatal injuries varied within each NORA sector. To have the greatest societal impact, these costs can be used to target resources for public and private sector research by industry. Published by Elsevier Ltd.

Is the Societal burden of fatal occupational injury different among NORA industry sectors?

Science.gov (United States)

Biddle, Elyce Anne

2015-01-01

Problem Since the implementation of the Occupational Safety and Health Act, safety and health in the work environment has seen marked improvement. Although these improvements are laudable, workplace hazards continue to plague the American worker. Understanding the economic burden of fatalities by industry sector is important to setting broad occupational safety and health research priorities. Cost estimates provide additional information about how fatal injuries affect society and hence can improve injury prevention program planning, policy analysis, evaluation, and advocacy. Method This study estimated the total, mean, and median societal costs by worker and case characteristic in 2003–2006 for the industry sectors identified in the National Institute for Occupational Safety and Health National Occupational Research Agenda (NORA). Analyses were conducted with restricted access to the Bureau of Labor Statistics Census of Fatal Occupational Injuries data. These data exclude military personnel, decedents with unknown age or sex, and fatalities occurring in New York City. Societal costs were estimated using the cost-of-illness approach, which combines direct and indirect costs to yield an overall cost of an fatal occupational injury. Results During this period, the cost of the 22,197 fatal occupational injuries exceeded $21 billion. The mean and median costs of these fatalities were $960,000 and $944,000 respectively. Total societal costs by NORA sector ranged from a high of $5.8 billion in Services to a low of $530 million in Healthcare and Social Assistance with mean costs ranging from the nearly $800,000 in Agriculture, Forestry, and Fishing to almost $1.1 million in Mining. Discussion The societal costs—total, mean, and median costs—of case and worker characteristics for occupational fatal injuries varied within each NORA sector. Impact on Industry To have the greatest societal impact, these costs can be used to target resources for public and private sector

Influence of filler alignment in the mechanical and electrical properties of carbon nanotubes/epoxy nanocomposites

Energy Technology Data Exchange (ETDEWEB)

Felisberto, M. [LPyMC, FCEyN-UBA and IFIBA-CONICET, Pab I Ciudad Universitaria, Buenos Aires 1428 (Argentina); INQUIMAE-CONICET-UBA, Pab II Ciudad Universitaria, Buenos Aires 1428 (Argentina); Arias-Duran, A. [LPyMC, FCEyN-UBA and IFIBA-CONICET, Pab I Ciudad Universitaria, Buenos Aires 1428 (Argentina); Ramos, J.A.; Mondragon, I. [Dep. Ingenieria Quimica y M. Ambiente. Esc. Politecnica. UPV/EHU, Pza. Europa 1, Donostia-San Sebastian 20018 (Spain); Candal, R. [INQUIMAE-CONICET-UBA, Pab II Ciudad Universitaria, Buenos Aires 1428 (Argentina); Escuela de Ciencia y Tecnologia-UNSAM, San Martin, Prov. De Buenos Aires (Argentina); Goyanes, S. [LPyMC, FCEyN-UBA and IFIBA-CONICET, Pab I Ciudad Universitaria, Buenos Aires 1428 (Argentina); Rubiolo, G.H., E-mail: rubiolo@cnea.gov.ar [LPyMC, FCEyN-UBA and IFIBA-CONICET, Pab I Ciudad Universitaria, Buenos Aires 1428 (Argentina); Dep. Materiales, Comision Nacional de Energia Atomica (CNEA-CAC), Avda Gral Paz 1499, B1650KNA San Martin (Argentina)

2012-08-15

In this work, we report the mechanical and electrical properties of carbon nanotubes/epoxy composites prepared with aligned and randomly oriented nanotubes as filler. The samples are disks of 30 mm in diameter and 3 mm in thickness. To obtain the carbon nanotubes alignment, an external electric field (250 VAC; 50 Hz) was applied through the thickness of the sample during all the cure process. The AC electrical current was measured, during the cure, as a strategy to determine the optimum time in which the alignment reaches the maximum value. DC conductivity measured after the cure shows a percolation threshold in the filler content one order of magnitude smaller for composites with aligned nanotubes than for composites with randomly oriented filler (from 0.06 to 0.5 wt%). In the percolation threshold, the achieved conductivity was 1.4 Multiplication-Sign 10{sup -5} Sm{sup -1}. In both cases, aligned and randomly distributed carbon nanotube composites, the wear resistance increases with the addition of the filler while the Rockwell hardness decreases independently of the nanotubes alignment.

The struggle for strategic alignment in multinational corporations: Managing readjustment during global expansion

NARCIS (Netherlands)

Rondinelli, Dennis; Rosen, Benson; Drori, Israel

2001-01-01

As corporations expand internationally, their ability to align their internal business strategies and management practices to conditions in external marketplaces becomes critical for sustaining growth and expanding market share. When international expansion decisions become 'unaligned' with business

Reducing beam shaper alignment complexity: diagnostic techniques for alignment and tuning

Science.gov (United States)

Lizotte, Todd E.

2011-10-01

Safe and efficient optical alignment is a critical requirement for industrial laser systems used in a high volume manufacturing environment. Of specific interest is the development of techniques to align beam shaping optics within a beam line; having the ability to instantly verify by a qualitative means that each element is in its proper position as the beam shaper module is being aligned. There is a need to reduce these types of alignment techniques down to a level where even a newbie to optical alignment will be able to complete the task. Couple this alignment need with the fact that most laser system manufacturers ship their products worldwide and the introduction of a new set of variables including cultural and language barriers, makes this a top priority for manufacturers. Tools and methodologies for alignment of complex optical systems need to be able to cross these barriers to ensure the highest degree of up time and reduce the cost of maintenance on the production floor. Customers worldwide, who purchase production laser equipment, understand that the majority of costs to a manufacturing facility is spent on system maintenance and is typically the largest single controllable expenditure in a production plant. This desire to reduce costs is driving the trend these days towards predictive and proactive, not reactive maintenance of laser based optical beam delivery systems [10]. With proper diagnostic tools, laser system developers can develop proactive approaches to reduce system down time, safe guard operational performance and reduce premature or catastrophic optics failures. Obviously analytical data will provide quantifiable performance standards which are more precise than qualitative standards, but each have a role in determining overall optical system performance [10]. This paper will discuss the use of film and fluorescent mirror devices as diagnostic tools for beam shaper module alignment off line or in-situ. The paper will also provide an overview

Linking levels of societal and ecosystems metabolism of water in a Mediterranean watershed

Science.gov (United States)

Cabello, V.

2014-12-01

Water resources degradation is a complex environmental problem that involves multiple dimensions and scales of analysis. The Socio-Ecological Systems Water Metabolism has been proposed as a general holistic framework to deal with integrated analysis of water use sustainability (Madrid and Giampietro 2014). The innovation of the approach is that it sets the research focus beyond the classical supply-demand modeling to societal integrity and ecosystems integrity. To do so, it integrates quantitative grammars of water use (relating water exchange to societal and ecosystems organization) and qualitative methods (discourse analysis). This work presents the first case study focused at a river basin extent: the Upper Andarax, in South-East Spain. Water metabolism is indicated at multiple levels for ecosystems and society. To deal with the interfaces among them, relational indicators of water exploitation, water use and impact over ecosystems are used alongside policies and narratives analysis.While being a rather not intensively exploited river basin (year Water Exploitation Index~0.3 blue water,~0.15 green water), impacts over water bodies are yet important (periodic aquifer overdraft, biological degradation of the river) especially during dry season. Perceived mayor problems of water sustainability are generated by the not integration of different policies at European, national and regional scales: while the water authority establishes a compulsory reduction over water withdrawal to attend environmental flows, agricultural markets force to raise productivity increasing water demands. Adaptation strategies are divided among irrigation efficiency improvement and a reorientation of the economy towards touristic activities. Both of them entail specific trade-offs to be deemed. Aquifer-river interactions and climate change impacts are yet mayor research challenges.

Tidal alignment of galaxies

Energy Technology Data Exchange (ETDEWEB)

Blazek, Jonathan; Vlah, Zvonimir; Seljak, Uroš

2015-08-01

We develop an analytic model for galaxy intrinsic alignments (IA) based on the theory of tidal alignment. We calculate all relevant nonlinear corrections at one-loop order, including effects from nonlinear density evolution, galaxy biasing, and source density weighting. Contributions from density weighting are found to be particularly important and lead to bias dependence of the IA amplitude, even on large scales. This effect may be responsible for much of the luminosity dependence in IA observations. The increase in IA amplitude for more highly biased galaxies reflects their locations in regions with large tidal fields. We also consider the impact of smoothing the tidal field on halo scales. We compare the performance of this consistent nonlinear model in describing the observed alignment of luminous red galaxies with the linear model as well as the frequently used "nonlinear alignment model," finding a significant improvement on small and intermediate scales. We also show that the cross-correlation between density and IA (the "GI" term) can be effectively separated into source alignment and source clustering, and we accurately model the observed alignment down to the one-halo regime using the tidal field from the fully nonlinear halo-matter cross correlation. Inside the one-halo regime, the average alignment of galaxies with density tracers no longer follows the tidal alignment prediction, likely reflecting nonlinear processes that must be considered when modeling IA on these scales. Finally, we discuss tidal alignment in the context of cosmic shear measurements.

Conspiracy theories as part of history: The role of societal crisis situations.

Science.gov (United States)

van Prooijen, Jan-Willem; Douglas, Karen M

2017-07-01

In the present contribution, we examine the link between societal crisis situations and belief in conspiracy theories. Contrary to common assumptions, belief in conspiracy theories has been prevalent throughout human history. We first illustrate historical incidents suggesting that societal crisis situations-defined as impactful and rapid societal change that calls established power structures, norms of conduct, or even the existence of specific people or groups into question-have stimulated belief in conspiracy theories. We then review the psychological literature to explain why this is the case. Evidence suggests that the aversive feelings that people experience when in crisis-fear, uncertainty, and the feeling of being out of control-stimulate a motivation to make sense of the situation, increasing the likelihood of perceiving conspiracies in social situations. We then explain that after being formed, conspiracy theories can become historical narratives that may spread through cultural transmission. We conclude that conspiracy theories originate particularly in crisis situations and may form the basis for how people subsequently remember and mentally represent a historical event.

Fast global sequence alignment technique

KAUST Repository

Bonny, Mohamed Talal; Salama, Khaled N.

2011-01-01

fast alignment algorithm, called 'Alignment By Scanning' (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the wellknown sequence alignment algorithms, the 'GAP' (which is heuristic) and the 'Needleman

'Compromise position' image alignment to accommodate independent motion of multiple clinical target volumes during radiotherapy: A high risk prostate cancer example

International Nuclear Information System (INIS)

Rosewall, Tara; Alasti, Hamideh; Bayley, Andrew; Yan, Jing

2017-01-01

Inclusion of multiple independently moving clinical target volumes (CTVs) in the irradiated volume causes an image guidance conundrum. The purpose of this research was to use high risk prostate cancer as a clinical example to evaluate a 'compromise' image alignment strategy. The daily pre-treatment orthogonal EPI for 14 consecutive patients were included in this analysis. Image matching was performed by aligning to the prostate only, the bony pelvis only and using the 'compromise' strategy. Residual CTV surrogate displacements were quantified for each of the alignment strategies. Analysis of the 388 daily fractions indicated surrogate displacements were well-correlated in all directions (r 2 = 0.95 (LR), 0.67 (AP) and 0.59 (SI). Differences between the surrogates displacements (95% range) were −0.4 to 1.8 mm (LR), −1.2 to 5.2 mm (SI) and −1.2 to 5.2 mm (AP). The distribution of the residual displacements was significantly smaller using the 'compromise' strategy, compared to the other strategies (p 0.005). The 'compromise' strategy ensured the CTV was encompassed by the PTV in all fractions, compared to 47 PTV violations when aligned to prostate only. This study demonstrated the feasibility of a compromise position image guidance strategy to accommodate simultaneous displacements of two independently moving CTVs. Application of this strategy was facilitated by correlation between the CTV displacements and resulted in no geometric excursions of the CTVs beyond standard sized PTVs. This simple image guidance strategy may also be applicable to other disease sites that concurrently irradiate multiple CTVs, such as head and neck, lung and cervix cancer.

The Influence of Psychological and Societal Factors on Student ...

African Journals Online (AJOL)

The study examined the influence of psychological and societal factors on students' performance in mathematics at Senior Secondary School Level in. Ilorin metropolis of Kwara state. A simple random sampling technique was used to sample three hundred secondary school students who supplied information on the ...

Development of stock markets, societal norms and legal institutions

NARCIS (Netherlands)

Garretsen, Harry; Lensink, Robert; Sterken, Elmer

2000-01-01

We explain the development of stock markets by both legal and societal determinants and analyze the relevance of both determinants in the Levine-Zervos (1998) cross-sectional growth regressions. We argue that the legal indicators as developed by La Porta, Lopez-de-Silanes, Shleifer and Vishny (1998)

SKB's program for societal research 2004-2011. An evaluation

International Nuclear Information System (INIS)

Soederberg, Olof

2012-04-01

This evaluation of the program of societal research that SKB conducted the years 2004-2011 has been performed on behalf of Swedish Nuclear Fuel and Waste Management Company (SKB). The review has focused on answers to a series of questions as follows: General questions - Why was a program started? - What was SKB's purpose with the program? - Does the result mean that the objective has been achieved? - Has the program had effects (positive or negative) that were not anticipated when the purpose was formulated? - Strengths and weaknesses of the program? Questions about the implementation - How did announcement and selection procedures work? - Which forms were used for reporting results from the research projects? Questions about the continued investment in societal research - Are there such needs? - In that case, is it in SKB's interest to contribute financially to such research? - What forms might be appropriate if SKB sees interest to contribute financially to such research?

Mapping the Delivery of Societal Benefit through the International Arctic Observations Assessment Framework

Science.gov (United States)

Lev, S. M.; Gallo, J.

2017-12-01

The international Arctic scientific community has identified the need for a sustained and integrated portfolio of pan-Arctic Earth-observing systems. In 2017, an international effort was undertaken to develop the first ever Value Tree framework for identifying common research and operational objectives that rely on Earth observation data derived from Earth-observing systems, sensors, surveys, networks, models, and databases to deliver societal benefits in the Arctic. A Value Tree Analysis is a common tool used to support decision making processes and is useful for defining concepts, identifying objectives, and creating a hierarchical framework of objectives. A multi-level societal benefit area value tree establishes the connection from societal benefits to the set of observation inputs that contribute to delivering those benefits. A Value Tree that relies on expert domain knowledge from Arctic and non-Arctic nations, international researchers, Indigenous knowledge holders, and other experts to develop a framework to serve as a logical and interdependent decision support tool will be presented. Value tree examples that map the contribution of Earth observations in the Arctic to achieving societal benefits will be presented in the context of the 2017 International Arctic Observations Assessment Framework. These case studies will highlight specific observing products and capability groups where investment is needed to contribute to the development of a sustained portfolio of Arctic observing systems.

Living renal donors: optimizing the imaging strategy--decision- and cost-effectiveness analysis

NARCIS (Netherlands)

Y.S. Liem (Ylian Serina); M.C.J.M. Kock (Marc); W. Weimar (Willem); K. Visser (Karen); M.G.M. Hunink (Myriam); J.N.M. IJzermans (Jan)

2003-01-01

textabstractPURPOSE: To determine the most cost-effective strategy for preoperative imaging performed in potential living renal donors. MATERIALS AND METHODS: In a decision-analytic model, the societal cost-effectiveness of digital subtraction angiography (DSA), gadolinium-enhanced

Trading of shares in the Societates Publicanorum?

OpenAIRE

Poitras, Geoffrey; Geranio, Manuela

2016-01-01

This paper demonstrates the often repeated modern claim of significant trading in ‘shares of the societates publicanorum’ (partes) during the late Roman Republic cannot be supported using the available ‘primary sources’. Building on recent contributions detailing the economy of the late Republic, in general, and the tax farming activities of the publicani, in particular, an alternative more plausible legal and commercial explanation of the ‘primary sources’ – especially In Vatinium [12.29] an...

Activity-Based Information Integrating the operations strategy

Directory of Open Access Journals (Sweden)

José Augusto da Rocha de Araujo

2005-12-01

Full Text Available In the globalized world, companies seek for new operations strategies to ensure world corporate success. This article analyzes how the cost management models – both traditional and activity-based, aid the planning and management of corporate globalized operations. The efficacy of the models application depends on their alignment with the competitive strategy. Companies must evaluate the nature of the competition and its competitive priorities; they should then define the necessary and sufficient dependence level on costs information. In this article, three dependence levels are presented: operational, decision support and strategic control. The result of the research shows the importance of alignment between the cost management model and the competitive strategy for corporate success, and confirms the adequacy of the activity-based costing model as a supporting tool for decision taking in a global strategy. Case studies in world class companies in Brazil are presented.

LHCb full-detector real-time alignment and calibration: latest developments and perspective

CERN Multimedia

Dziurda, Agnieszka

2018-01-01

A key ingredient of the data taking strategy used by the LHCb experiment at CERN in Run 2 is the novel real-time detector alignment and calibration. Data collected at the start of the fill are processed within minutes and used to update the alignment, while the calibration constants are evaluated hourly. This is one of the key elements which allow the reconstruction quality of the software trigger in Run-II to be as good as the offline quality of Run 1. The most recent developments of the real-time alignment and calibration paradigm enable the fully automated updates of the RICH detectors' mirror alignment and a novel calibration of the calorimeter systems. Both evolutions improve the particle identification performance stability resulting in higher purity selections. The latter leads also to an improvement in the energy measurement of neutral particles, resulting in a 15% better mass resolution of radiative b-hadron decays. A large variety of improvements has been explored for the last year of Run 2 data tak...

Aligning economic impact with environmental benefits: a green strategy model

OpenAIRE

Gu, Q.; Lago, P.; Potenza, S.

2012-01-01

To achieve lower energy consumption many green strategies (e.g. virtualize applications and consolidate them on shared server machines, or optimize the usage of the private cloud by opening up to external consumers) have been discussed. In practice, however, the major incentive for a company to go green is reducing costs. While green strategies often focus on technical and environmental issues, they hardly address the economic impact that they may bring. If green strategies do not lead to an ...

Ancestral sequence alignment under optimal conditions

Directory of Open Access Journals (Sweden)

Brown Daniel G

2005-11-01

Full Text Available Abstract Background Multiple genome alignment is an important problem in bioinformatics. An important subproblem used by many multiple alignment approaches is that of aligning two multiple alignments. Many popular alignment algorithms for DNA use the sum-of-pairs heuristic, where the score of a multiple alignment is the sum of its induced pairwise alignment scores. However, the biological meaning of the sum-of-pairs of pairs heuristic is not obvious. Additionally, many algorithms based on the sum-of-pairs heuristic are complicated and slow, compared to pairwise alignment algorithms. An alternative approach to aligning alignments is to first infer ancestral sequences for each alignment, and then align the two ancestral sequences. In addition to being fast, this method has a clear biological basis that takes into account the evolution implied by an underlying phylogenetic tree. In this study we explore the accuracy of aligning alignments by ancestral sequence alignment. We examine the use of both maximum likelihood and parsimony to infer ancestral sequences. Additionally, we investigate the effect on accuracy of allowing ambiguity in our ancestral sequences. Results We use synthetic sequence data that we generate by simulating evolution on a phylogenetic tree. We use two different types of phylogenetic trees: trees with a period of rapid growth followed by a period of slow growth, and trees with a period of slow growth followed by a period of rapid growth. We examine the alignment accuracy of four ancestral sequence reconstruction and alignment methods: parsimony, maximum likelihood, ambiguous parsimony, and ambiguous maximum likelihood. Additionally, we compare against the alignment accuracy of two sum-of-pairs algorithms: ClustalW and the heuristic of Ma, Zhang, and Wang. Conclusion We find that allowing ambiguity in ancestral sequences does not lead to better multiple alignments. Regardless of whether we use parsimony or maximum likelihood, the

HR strategy – necessity or fad for business sustainability?

Directory of Open Access Journals (Sweden)

Ghinea Valentina Mihaela

2016-07-01

Full Text Available The present paper pleads for the awareness of HR strategy importance, in terms of proper design and implementation, as they definitely could impede or sustain the development of an organization. By making use of G.VALI, the model of organizational culture dynamics, we look for revealing the impact that (non-existence of HR strategy, its alignment and coherence could have on the organization success. As proven by human experience, all types of strategies could work and be effective in certain conditions. Even more, no one can say that one strategy is better than other. However, in the same way, there is no guarantee of some strategies success. In this light, the difference lays in the handy and clever interlock of the country specific advantages and firm (-tobe specific advantages. For achieving this specific aim, vertical (alignment and horizontal (coherence integration of each functional strategy must be ensured.

Clear aligners in orthodontic treatment.

Science.gov (United States)

Weir, T

2017-03-01

Since the introduction of the Tooth Positioner (TP Orthodontics) in 1944, removable appliances analogous to clear aligners have been employed for mild to moderate orthodontic tooth movements. Clear aligner therapy has been a part of orthodontic practice for decades, but has, particularly since the introduction of Invisalign appliances (Align Technology) in 1998, become an increasingly common addition to the orthodontic armamentarium. An internet search reveals at least 27 different clear aligner products currently on offer for orthodontic treatment. The present paper will highlight the increasing popularity of clear aligner appliances, as well as the clinical scope and the limitations of aligner therapy in general. Further, the paper will outline the differences between the various types of clear aligner products currently available. © 2017 Australian Dental Association.

MUON DETECTORS: ALIGNMENT

CERN Multimedia

Gervasio Gomez

2012-01-01

  The new alignment for the DT chambers has been successfully used in physics analysis starting with the 52X Global Tag. The remaining main areas of development over the next few months will be preparing a new track-based CSC alignment and producing realistic APEs (alignment position errors) and MC misalignment scenarios to match the latest muon alignment constants. Work on these items has been delayed from the intended timeline, mostly due to a large involvement of the muon alignment man-power in physics analyses over the first half of this year. As CMS keeps probing higher and higher energies, special attention must be paid to the reconstruction of very-high-energy muons. Recent muon POG reports from mid-June show a φ-dependence in curvature bias in Monte Carlo samples. This bias is observed already at the tracker level, where it is constant with muon pT, while it grows with pT as muon chamber information is added to the tracks. Similar studies show a much smaller effect in data, at le...

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G. Gomez

2010-01-01

For the last three months, the Muon Alignment group has focussed on providing a new, improved set of alignment constants for the end-of-year data reprocessing. These constants were delivered on time and approved by the CMS physics validation team on November 17. The new alignment incorporates several improvements over the previous one from March for nearly all sub-systems. Motivated by the loss of information from a hardware failure in May (an entire MAB was lost), the optical barrel alignment has moved from a modular, super-plane reconstruction, to a full, single loop calculation of the entire geometry for all DTs in stations 1, 2 and 3. This makes better use of the system redundancy, mitigating the effect of the information loss. Station 4 is factorised and added afterwards to make the system smaller (and therefore faster to run), and also because the MAB calibration at the MB4 zone is less precise. This new alignment procedure was tested at 0 T against photogrammetry resulting in precisions of the order...

Alignment sensing and control in advanced LIGO

International Nuclear Information System (INIS)

Barsotti, L; Evans, M; Fritschel, P

2010-01-01

The advanced LIGO detectors are currently in their final design stage, and the installation phase will start at the end of 2010: they will have about 10 times better sensitivity than initial LIGO, with a sensitive band ranging from 10 Hz to 10 kHz. As compared with previous LIGO detectors, there will be increased complexity in the optical configuration, improved seismic isolation system and significantly higher power circulating in the arm cavities. In the new detectors, the control of the angular orientation of the mirrors will be particularly challenging. The advanced LIGO (aLIGO) mirrors need to have a residual angular motion of the order of 1 nrad RMS in order to achieve high sensitivity. In the high power regime, the torque induced by radiation pressure effects will be comparable with the restoring torque of the mirror suspension, such that we must think of the opto-mechanical response, instead of just the mechanical response. These modifications have to be considered in order to design the control strategy for keeping the mirrors well aligned. Moreover, to meet the sensitivity target the alignment control noise coupled to the gravitational-wave channel must be well below 6x10 -18 m/√Hz at 10 Hz. We developed a model of the alignment sensing and control scheme of aLIGO which takes into account radiation pressure effects and meets the noise target.

How accurate is anatomic limb alignment in predicting mechanical limb alignment after total knee arthroplasty?

Science.gov (United States)

Lee, Seung Ah; Choi, Sang-Hee; Chang, Moon Jong

2015-10-27

Anatomic limb alignment often differs from mechanical limb alignment after total knee arthroplasty (TKA). We sought to assess the accuracy, specificity, and sensitivity for each of three commonly used ranges for anatomic limb alignment (3-9°, 5-10° and 2-10°) in predicting an acceptable range (neutral ± 3°) for mechanical limb alignment after TKA. We also assessed whether the accuracy of anatomic limb alignment was affected by anatomic variation. This retrospective study included 314 primary TKAs. The alignment of the limb was measured with both anatomic and mechanical methods of measurement. We also measured anatomic variation, including the femoral bowing angle, tibial bowing angle, and neck-shaft angle of the femur. All angles were measured on the same full-length standing anteroposterior radiographs. The accuracy, specificity, and sensitivity for each range of anatomic limb alignment were calculated and compared using mechanical limb alignment as the reference standard. The associations between the accuracy of anatomic limb alignment and anatomic variation were also determined. The range of 2-10° for anatomic limb alignment showed the highest accuracy, but it was only 73 % (3-9°, 65 %; 5-10°, 67 %). The specificity of the 2-10° range was 81 %, which was higher than that of the other ranges (3-9°, 69 %; 5-10°, 67 %). However, the sensitivity of the 2-10° range to predict varus malalignment was only 16 % (3-9°, 35 %; 5-10°, 68 %). In addition, the sensitivity of the 2-10° range to predict valgus malalignment was only 43 % (3-9°, 71 %; 5-10°, 43 %). The accuracy of anatomical limb alignment was lower for knees with greater femoral (odds ratio = 1.2) and tibial (odds ratio = 1.2) bowing. Anatomic limb alignment did not accurately predict mechanical limb alignment after TKA, and its accuracy was affected by anatomic variation. Thus, alignment after TKA should be assessed by measuring mechanical alignment rather than anatomic

Strategic Alignment and New Product Development

DEFF Research Database (Denmark)

Acur, Nuran; Kandemir, Destan; Boer, Harry

2012-01-01

Strategic alignment is widely accepted as a prerequisite for a firm’s success, but insight into the role of alignment in, and its impact on, the new product evelopment (NPD) process and its performance is less well developed. Most publications on this topic either focus on one form of alignment...... of NPD performance indicators. Strategic planning and innovativeness appear to affect technological, market, and NPD-marketing alignment positively. Environmental munificence is negatively associated with NPD-marketing alignment, but has no effect on the two other forms of alignment. Technological change...... has a positive effect on technological alignment, a negative effect on NPD-marketing alignment, but no effect on market alignment. These findings suggest that internal capabilities are more likely to be associated with the development of strategic alignment than environmental factors are. Furthermore...

Measuring societal effects of transdisciplinary research projects: design and application of an evaluation method.

Science.gov (United States)

Walter, Alexander I; Helgenberger, Sebastian; Wiek, Arnim; Scholz, Roland W

2007-11-01

Most Transdisciplinary Research (TdR) projects combine scientific research with the building of decision making capacity for the involved stakeholders. These projects usually deal with complex, societally relevant, real-world problems. This paper focuses on TdR projects, which integrate the knowledge of researchers and stakeholders in a collaborative transdisciplinary process through structured methods of mutual learning. Previous research on the evaluation of TdR has insufficiently explored the intended effects of transdisciplinary processes on the real world (societal effects). We developed an evaluation framework for assessing the societal effects of transdisciplinary processes. Outputs (measured as procedural and product-related involvement of the stakeholders), impacts (intermediate effects connecting outputs and outcomes) and outcomes (enhanced decision making capacity) are distinguished as three types of societal effects. Our model links outputs and outcomes of transdisciplinary processes via the impacts using a mediating variables approach. We applied this model in an ex post evaluation of a transdisciplinary process. 84 out of 188 agents participated in a survey. The results show significant mediation effects of the two impacts "network building" and "transformation knowledge". These results indicate an influence of a transdisciplinary process on the decision making capacity of stakeholders, especially through social network building and the generation of knowledge relevant for action.

Alignment of the ATLAS inner detector for the LHC Run II

CERN Document Server

Butti, Pierfrancesco; The ATLAS collaboration

2015-01-01

ATLAS a multipurpose experiment at the LHC proton-proton collider. Its physics goals require high resolution, unbiased measurement of all charged particle kinematic parameters. These critically depend on the layout and performance of the tracking system, notably quality of its offline alignment. ATLAS is equipped with a tracking system built using different technologies, silicon planar sensors (pixel and micro-strip) and gaseous drift- tubes, all embedded in a 2T solenoidal magnetic field. For the LHC Run II, the system has been upgraded with the installation of a new pixel layer, the Insertable B-layer (IBL). Offline track alignment of the ATLAS tracking system has to deal with about 700,000 degrees of freedom (DoF) defining its geometrical parameters. The task requires using very large data sets and represents a considerable numerical challenge in terms of both CPU time and precision. The adopted strategy uses a hierarchical approach to alignment, combining local and global least squares techniques. An outl...

Geospatial decision support systems for societal decision making

Science.gov (United States)

Bernknopf, R.L.

2005-01-01

While science provides reliable information to describe and understand the earth and its natural processes, it can contribute more. There are many important societal issues in which scientific information can play a critical role. Science can add greatly to policy and management decisions to minimize loss of life and property from natural and man-made disasters, to manage water, biological, energy, and mineral resources, and in general, to enhance and protect our quality of life. However, the link between science and decision-making is often complicated and imperfect. Technical language and methods surround scientific research and the dissemination of its results. Scientific investigations often are conducted under different conditions, with different spatial boundaries, and in different timeframes than those needed to support specific policy and societal decisions. Uncertainty is not uniformly reported in scientific investigations. If society does not know that data exist, what the data mean, where to use the data, or how to include uncertainty when a decision has to be made, then science gets left out -or misused- in a decision making process. This paper is about using Geospatial Decision Support Systems (GDSS) for quantitative policy analysis. Integrated natural -social science methods and tools in a Geographic Information System that respond to decision-making needs can be used to close the gap between science and society. The GDSS has been developed so that nonscientists can pose "what if" scenarios to evaluate hypothetical outcomes of policy and management choices. In this approach decision makers can evaluate the financial and geographic distribution of potential policy options and their societal implications. Actions, based on scientific information, can be taken to mitigate hazards, protect our air and water quality, preserve the planet's biodiversity, promote balanced land use planning, and judiciously exploit natural resources. Applications using the

ABS: Sequence alignment by scanning

KAUST Repository

Bonny, Mohamed Talal; Salama, Khaled N.

2011-01-01

Sequence alignment is an essential tool in almost any computational biology research. It processes large database sequences and considered to be high consumers of computation time. Heuristic algorithms are used to get approximate but fast results. We introduce fast alignment algorithm, called Alignment By Scanning (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the well-known alignment algorithms, the FASTA (which is heuristic) and the 'Needleman-Wunsch' (which is optimal). The proposed algorithm achieves up to 76% enhancement in alignment score when it is compared with the FASTA Algorithm. The evaluations are conducted using different lengths of DNA sequences. © 2011 IEEE.

ABS: Sequence alignment by scanning

KAUST Repository

Bonny, Mohamed Talal

2011-08-01

Sequence alignment is an essential tool in almost any computational biology research. It processes large database sequences and considered to be high consumers of computation time. Heuristic algorithms are used to get approximate but fast results. We introduce fast alignment algorithm, called Alignment By Scanning (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the well-known alignment algorithms, the FASTA (which is heuristic) and the \\'Needleman-Wunsch\\' (which is optimal). The proposed algorithm achieves up to 76% enhancement in alignment score when it is compared with the FASTA Algorithm. The evaluations are conducted using different lengths of DNA sequences. © 2011 IEEE.

Fast global sequence alignment technique

KAUST Repository

Bonny, Mohamed Talal

2011-11-01

Bioinformatics database is growing exponentially in size. Processing these large amount of data may take hours of time even if super computers are used. One of the most important processing tool in Bioinformatics is sequence alignment. We introduce fast alignment algorithm, called \\'Alignment By Scanning\\' (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the wellknown sequence alignment algorithms, the \\'GAP\\' (which is heuristic) and the \\'Needleman-Wunsch\\' (which is optimal). The proposed algorithm achieves up to 51% enhancement in alignment score when it is compared with the GAP Algorithm. The evaluations are conducted using different lengths of DNA sequences. © 2011 IEEE.

Implementation of computer-based patient records in primary care: the societal health economic effects.

OpenAIRE

Arias-Vimárlund, V.; Ljunggren, M.; Timpka, T.

1996-01-01

OBJECTIVE: Exploration of the societal health economic effects occurring during the first year after implementation of Computerised Patient Records (CPRs) at Primary Health Care (PHC) centres. DESIGN: Comparative case studies of practice processes and their consequences one year after CPR implementation, using the constant comparison method. Application of transaction-cost analyses at a societal level on the results. SETTING: Two urban PHC centres under a managed care contract in Ostergötland...

Factors influencing societal response of nanotechnology : an expert stakeholder analysis

NARCIS (Netherlands)

Gupta, N.; Fischer, A.R.H.; Lans, van der I.A.; Frewer, L.J.

2012-01-01

Nanotechnology can be described as an emerging technology and, as has been the case with other emerging technologies such as genetic modification, different socio-psychological factors will potentially influence societal responses to its development and application. These factors will play an

Pareto optimal pairwise sequence alignment.

Science.gov (United States)

DeRonne, Kevin W; Karypis, George

2013-01-01

Sequence alignment using evolutionary profiles is a commonly employed tool when investigating a protein. Many profile-profile scoring functions have been developed for use in such alignments, but there has not yet been a comprehensive study of Pareto optimal pairwise alignments for combining multiple such functions. We show that the problem of generating Pareto optimal pairwise alignments has an optimal substructure property, and develop an efficient algorithm for generating Pareto optimal frontiers of pairwise alignments. All possible sets of two, three, and four profile scoring functions are used from a pool of 11 functions and applied to 588 pairs of proteins in the ce_ref data set. The performance of the best objective combinations on ce_ref is also evaluated on an independent set of 913 protein pairs extracted from the BAliBASE RV11 data set. Our dynamic-programming-based heuristic approach produces approximated Pareto optimal frontiers of pairwise alignments that contain comparable alignments to those on the exact frontier, but on average in less than 1/58th the time in the case of four objectives. Our results show that the Pareto frontiers contain alignments whose quality is better than the alignments obtained by single objectives. However, the task of identifying a single high-quality alignment among those in the Pareto frontier remains challenging.

Challenge Based Innovation: Translating Fundamental Research into Societal Applications

Science.gov (United States)

Kurikka, Joona; Utriainen, Tuuli; Repokari, Lauri

2016-01-01

This paper is based on work done at IdeaSquare, a new innovation experiment at CERN, the European Organization for Nuclear Research. The paper explores the translation of fundamental research into societal applications with the help of multidisciplinary student teams, project- and problem-based learning and design thinking methods. The theme is…

Alignment for CSR

International Nuclear Information System (INIS)

Wang Shoujin; Man Kaidi; Guo Yizhen; Cai Guozhu; Guo Yuhui

2002-01-01

Cooled Storage Ring of Heavy Ion Research Facility in Lanzhou (HIRFL-CSR) belongs to China great scientific project in China. The alignment for it is very difficult because of very large area and very high accuracy. For the special case in HIRFL-CSR, some new methods and new instruments are used, including the construction of survey control network, the usage of laser tracker, and CSR alignment database system with applications developed to store and analyze data. The author describes the whole procedure of CSR alignment

The Relationship between IT Outsourcing and Business and IT Alignment: an Explorative Study

NARCIS (Netherlands)

Aleksandar Keratsinov; Gilbert Gilbert Silvius; Joanna Turkiewicz; Harm Spoor

2013-01-01

Outsourcing of business processes and information technology (IT) operations is an important trend in large and middle-sized organizations. However, outsourcing could affect the organization’s ability to align its IT with business strategy and operations. This article reports a qualitative study

Strategies for Research, Education, and Innovation, A University's Considerations

DEFF Research Database (Denmark)

Møller, Jacob Steen

2004-01-01

Engineering (BYG•DTU) at The Technical University of Denmark (DTU) to this challenge are described: The Department has been reorganised and a new strategy has been adopted. The strategy was developed in collaboration with industry partners. The Strategy focuses on a) analysis and design of safe and economic......It is argued that the building and construction sector will maintain and even increase its economic and societal importance. In spite of this the private R&D effort in the sector is relatively modest, which in turn makes public research more important. The responds of the Department of Civil...

A generalized global alignment algorithm.

Science.gov (United States)

Huang, Xiaoqiu; Chao, Kun-Mao

2003-01-22

Homologous sequences are sometimes similar over some regions but different over other regions. Homologous sequences have a much lower global similarity if the different regions are much longer than the similar regions. We present a generalized global alignment algorithm for comparing sequences with intermittent similarities, an ordered list of similar regions separated by different regions. A generalized global alignment model is defined to handle sequences with intermittent similarities. A dynamic programming algorithm is designed to compute an optimal general alignment in time proportional to the product of sequence lengths and in space proportional to the sum of sequence lengths. The algorithm is implemented as a computer program named GAP3 (Global Alignment Program Version 3). The generalized global alignment model is validated by experimental results produced with GAP3 on both DNA and protein sequences. The GAP3 program extends the ability of standard global alignment programs to recognize homologous sequences of lower similarity. The GAP3 program is freely available for academic use at http://bioinformatics.iastate.edu/aat/align/align.html.

Pairwise Sequence Alignment Library

Energy Technology Data Exchange (ETDEWEB)

2015-05-20

Vector extensions, such as SSE, have been part of the x86 CPU since the 1990s, with applications in graphics, signal processing, and scientific applications. Although many algorithms and applications can naturally benefit from automatic vectorization techniques, there are still many that are difficult to vectorize due to their dependence on irregular data structures, dense branch operations, or data dependencies. Sequence alignment, one of the most widely used operations in bioinformatics workflows, has a computational footprint that features complex data dependencies. The trend of widening vector registers adversely affects the state-of-the-art sequence alignment algorithm based on striped data layouts. Therefore, a novel SIMD implementation of a parallel scan-based sequence alignment algorithm that can better exploit wider SIMD units was implemented as part of the Parallel Sequence Alignment Library (parasail). Parasail features: Reference implementations of all known vectorized sequence alignment approaches. Implementations of Smith Waterman (SW), semi-global (SG), and Needleman Wunsch (NW) sequence alignment algorithms. Implementations across all modern CPU instruction sets including AVX2 and KNC. Language interfaces for C/C++ and Python.

Model Based Reasoning by Introductory Students When Analyzing Earth Systems and Societal Challenges

Science.gov (United States)

Holder, L. N.; Herbert, B. E.

2014-12-01

Understanding how students use their conceptual models to reason about societal challenges involving societal issues such as natural hazard risk assessment, environmental policy and management, and energy resources can improve instructional activity design that directly impacts student motivation and literacy. To address this question, we created four laboratory exercises for an introductory physical geology course at Texas A&M University that engages students in authentic scientific practices by using real world problems and issues that affect societies based on the theory of situated cognition. Our case-study design allows us to investigate the various ways that students utilize model based reasoning to identify and propose solutions to societally relevant issues. In each of the four interventions, approximately 60 students in three sections of introductory physical geology were expected to represent and evaluate scientific data, make evidence-based claims about the data trends, use those claims to express conceptual models, and use their models to analyze societal challenges. Throughout each step of the laboratory exercise students were asked to justify their claims, models, and data representations using evidence and through the use of argumentation with peers. Cognitive apprenticeship was the foundation for instruction used to scaffold students so that in the first exercise they are given a partially completed model and in the last exercise students are asked to generate a conceptual model on their own. Student artifacts, including representation of earth systems, representation of scientific data, verbal and written explanations of models and scientific arguments, and written solutions to specific societal issues or environmental problems surrounding earth systems, were analyzed through the use of a rubric that modeled authentic expertise and students were sorted into three categories. Written artifacts were examined to identify student argumentation and

Progressive multiple sequence alignments from triplets

Directory of Open Access Journals (Sweden)

Stadler Peter F

2007-07-01

Full Text Available Abstract Background The quality of progressive sequence alignments strongly depends on the accuracy of the individual pairwise alignment steps since gaps that are introduced at one step cannot be removed at later aggregation steps. Adjacent insertions and deletions necessarily appear in arbitrary order in pairwise alignments and hence form an unavoidable source of errors. Research Here we present a modified variant of progressive sequence alignments that addresses both issues. Instead of pairwise alignments we use exact dynamic programming to align sequence or profile triples. This avoids a large fractions of the ambiguities arising in pairwise alignments. In the subsequent aggregation steps we follow the logic of the Neighbor-Net algorithm, which constructs a phylogenetic network by step-wisely replacing triples by pairs instead of combining pairs to singletons. To this end the three-way alignments are subdivided into two partial alignments, at which stage all-gap columns are naturally removed. This alleviates the "once a gap, always a gap" problem of progressive alignment procedures. Conclusion The three-way Neighbor-Net based alignment program aln3nn is shown to compare favorably on both protein sequences and nucleic acids sequences to other progressive alignment tools. In the latter case one easily can include scoring terms that consider secondary structure features. Overall, the quality of resulting alignments in general exceeds that of clustalw or other multiple alignments tools even though our software does not included heuristics for context dependent (mismatch scores.

LHCb : Novel real-time alignment and calibration of the LHCb Detector in Run2

CERN Multimedia

Tobin, Mark

2015-01-01

LHCb has introduced a novel real-time detector alignment and calibration strategy for LHC Run 2. Data collected at the start of the fill will be processed in a few minutes and used to update the alignment, while the calibration constants will be evaluated for each run. This procedure will improve the quality of the online alignment. For example, the vertex locator is retracted and reinserted for stable beam collisions in each fill to be centred on the primary vertex position in the transverse plane. Consequently its position changes on a fill-by-fill basis. Critically, this new realtime alignment and calibration procedure allows identical constants to be used in the online and offline reconstruction, thus improving the correlation between triggered and offline selected events. This offers the opportunity to optimise the event selection in the trigger by applying stronger constraints. The online calibration facilitates the use of hadronic particle identification using the RICH detectors at the trigger level. T...

Comparison of Lumbosacral Alignment in Geriatric and Non-Geriatric patients suffering low back pain.

Science.gov (United States)

Kocyigit, Burhan Fatih; Berk, Ejder

2018-01-01

Lumbosacral alignment is a crucial factor for an appropriate spinal function. Changes in spinal alignment lead to diminished body biomechanics. Additionally, lumbosacral alignment may affect quality of life, sagittal balance and fall risk in elderly. In this study, we aimed to compare lumbosacral alignment in geriatric and non-geriatric patients suffering from low back pain. A total of 202 (120 male and 82 female) patients who visited to physical medicine and rehabilitation clinic with low back pain between January 2017 and August 2017 were enrolled in this study. Standing lateral lumbar radiographs were obtained from the electronic hospital database. Lumbar lordosis angle, sacral tilt, lumbosacral angle and lumbosacral disc angle were calculated on lateral standing lumbar radiographs. The mean age of the non-geriatric group was 43.02 ± 13.20 years, the geriatric group was 71.61 ± 6.42 years. In geriatric patients, lumbar lordosis angle, sacral tilt and lumbosacral disc angle were significantly smaller (p = 0.042, p = 0.017 and p = 0.017). No significant differences were observed in lumbosacral angle between the groups (p = 0.508). Our study indicates the specific changes in lumbosacral alignment with aging. Identifying these changes in lumbosacral alignment in the geriatric population will enable to create proper rehabilitation strategies.

Belt Aligning Revisited

Directory of Open Access Journals (Sweden)

Yurchenko Vadim

2017-01-01

parts of the conveyor, the sides of the belt wear intensively. This results in reducing the life of the belt. The reasons for this phenomenon are well investigated, but the difficulty lies in the fact that they all act simultaneously. The belt misalignment prevention can be carried out in two ways: by minimizing the effect of causes and by aligning the belt. The construction of aligning devices and errors encountered in practice are considered in this paper. Self-aligning roller supports rotational in plan view are recommended as a means of combating the belt misalignment.

Antares beam-alignment-system performance

International Nuclear Information System (INIS)

Appert, Q.D.; Bender, S.C.

1983-01-01

The beam alignment system for the 24-beam-sector Antares CO 2 fusion laser automatically aligns more than 200 optical elements. A visible-wavelength alignment technique is employed which uses a telescope/TV system to view point-light sources appropriately located down the beamline. The centroids of the light spots are determined by a video tracker, which generates error signals used by the computer control system to move appropriate mirrors in a closed-loop system. Final touch-up alignment is accomplished by projecting a CO 2 alignment laser beam through the system and sensing its position at the target location. The techniques and control algorithms employed have resulted in alignment accuracies exceeding design requirements. By employing video processing to determine the centroids of diffraction images and by averaging over multiple TV frames, we achieve alignment accuracies better than 0.1 times system diffraction limits in the presence of air turbulence

A UNIFIED MODEL OF GRAIN ALIGNMENT: RADIATIVE ALIGNMENT OF INTERSTELLAR GRAINS WITH MAGNETIC INCLUSIONS

Energy Technology Data Exchange (ETDEWEB)

Hoang, Thiem [Canadian Institute for Theoretical Astrophysics, University of Toronto, 60 St. George Street, Toronto, ON M5S 3H8 (Canada); Lazarian, A. [Department of Astronomy, University of Wisconsin-Madison (United States)

2016-11-10

The radiative torque (RAT) alignment of interstellar grains with ordinary paramagnetic susceptibilities has been supported by earlier studies. The alignment of such grains depends on the so-called RAT parameter q {sup max}, which is determined by the grain shape. In this paper, we elaborate on our model of RAT alignment for grains with enhanced magnetic susceptibility due to iron inclusions, such that RAT alignment is magnetically enhanced, which we term the MRAT mechanism. Such grains can be aligned with high angular momentum at the so-called high- J attractor points, achieving a high degree of alignment. Using our analytical model of RATs, we derive the critical value of the magnetic relaxation parameter δ {sub m} to produce high- J attractor points as functions of q {sup max} and the anisotropic radiation angle relative to the magnetic field ψ . We find that if about 10% of the total iron abundance present in silicate grains is forming iron clusters, this is sufficient to produce high- J attractor points for all reasonable values of q {sup max}. To calculate the degree of grain alignment, we carry out numerical simulations of MRAT alignment by including stochastic excitations from gas collisions and magnetic fluctuations. We show that large grains can achieve perfect alignment when the high- J attractor point is present, regardless of the values of q {sup max}. Our obtained results pave the way for the physical modeling of polarized thermal dust emission as well as magnetic dipole emission. We also find that millimeter-sized grains in accretion disks may be aligned with the magnetic field if they are incorporated with iron nanoparticles.

Does Funding for Arctic Research Align with Research Priorities and Policy Needs? Trends in the USA, Canada and Europe

Science.gov (United States)

Murray, M. S.; Ibarguchi, G.; Rajdev, V.

2015-12-01

Over the past twenty years, increasing awareness and understanding of changes in the Arctic system, the stated desires of Arctic Peoples to be engaged in the research process, and a growing international interest in the region's resources have informed various stakeholders to undertake many Arctic science planning activities. Some examples of science planning include priority-setting for research, knowledge translation, stakeholder engagement, improved coordination, and international collaboration. The International Study of Arctic Change recently initiated an analysis of the extent to which alignment exists among stated science priorities, recognized societal needs, and funding patterns of the major North American and European agencies. In this paper, we present a decade of data on international funding patterns and data on two decades of science planning. We discuss whether funding patterns reflect the priority research questions and identified needs for information that are articulated in a myriad of Arctic research planning documents. The alignment in many areas remains poor, bringing into question the purpose of large-scale science planning if it does not lead to funding of those priorities identified by Arctic stakeholder communities (scientists, Arctic Peoples, planners, policy makers, the private sector, and others).

Nanofabricated racks of aligned and anchored DNA substrates for single-molecule imaging.

Science.gov (United States)

Gorman, Jason; Fazio, Teresa; Wang, Feng; Wind, Shalom; Greene, Eric C

2010-01-19

Single-molecule studies of biological macromolecules can benefit from new experimental platforms that facilitate experimental design and data acquisition. Here we develop new strategies to construct curtains of DNA in which the molecules are aligned with respect to one another and maintained in an extended configuration by anchoring both ends of the DNA to the surface of a microfluidic sample chamber that is otherwise coated with an inert lipid bilayer. This "double-tethered" DNA substrate configuration is established through the use of nanofabricated rack patterns comprised of two distinct functional elements: linear barriers to lipid diffusion that align DNA molecules anchored by one end to the bilayer and antibody-coated pentagons that provide immobile anchor points for the opposite ends of the DNA. These devices enable the alignment and anchoring of thousands of individual DNA molecules, which can then be visualized using total internal reflection fluorescence microscopy under conditions that do not require continuous application of buffer flow to stretch the DNA. This unique strategy offers the potential for studying protein-DNA interactions on large DNA substrates without compromising measurements through application of hydrodynamic force. We provide a proof-of-principle demonstration that double-tethered DNA curtains made with nanofabricated rack patterns can be used in a one-dimensional diffusion assay that monitors the motion of quantum dot-tagged proteins along DNA.

Evaluation of alignment marks using ASML ATHENA alignment system in 90nm BEOL process

CERN Document Server

Tan Chin Boon; Koh Hui Peng; Koo Chee, Kiong; Siew Yong Kong; Yeo Swee Hock

2003-01-01

As the critical dimension (CD) in integrated circuit (IC) device reduces, the total overlay budget needs to be more stringent. Typically, the allowable overlay error is 1/3 of the CD in the IC device. In this case, robustness of alignment mark is critical, as accurate signal is required by the scanner's alignment system to precisely align a layer of pattern to the previous layer. Alignment issue is more severe in back-end process partly due to the influenced of Chemical Mechanical Polishing (CMP), which contribute to the asymmetric or total destruction of the alignment marks. Alignment marks on the wafer can be placed along the scribe-line of the IC pattern. ASML scanner allows such type of wafer alignment using phase grating mark, known as Scribe-line Primary Mark (SPM) which can be fit into a standard 80um scribe-line. In this paper, we have studied the feasibility of introducing Narrow SPM (NSPM) to enable a smaller scribe-line. The width of NSPM has been shrunk down to 70% of the SPM and the length remain...

The Societal Nature of Subjectivity: An Interdisciplinary Methodological Challenge

Directory of Open Access Journals (Sweden)

Henning Salling Olesen

2012-09-01

Full Text Available The thematic issue presents a psycho-societal approach to qualitative empirical research in several areas of everyday social life. It is an approach which integrates a theory of subjectivity and an interpretation methodology which integrates hermeneutic experiences from text analysis and psychoanalysis. Its particular focus is on subjectivity—as an aspect of the research object and as an aspect of the research process. By the term "approach" is indicated the intrinsic connection between the theorizing of an empirical object and the reflection of the research process and the epistemic subject. In terms of methodology it revives the themes originally launched in FQS exactly ten years ago: "Subjectivity and Reflectivity in Qualitative Research" (BREUER, MRUCK & ROTH, 2002; MRUCK & BREUER, 2003. This editorial introduction presents the intellectual background of the psycho-societal methodology, reflects on its relevance and critical perspectives in a contemporary landscape of social science, and comments the way in which an international and interdisciplinary research group has developed this approach to profane empirical research. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs120345

The Societal Benefits and Costs of School Dropout Recovery

Directory of Open Access Journals (Sweden)

James S. Catterall

2011-01-01

Full Text Available This article reports an analysis of the societal benefits and costs of recovering school dropouts. Successful recovery is defined by subsequent graduation from high school. The analysis is based on established estimates of the societal costs of dropping out including reduced government tax collections and higher social costs of welfare, healthcare, and crime. These potential costs are cast as benefits when a dropout is recovered. A large dropout recovery program provides the setting for the analysis. Rigorous attention is given to accurate estimation of the number of students who would not have graduated without the program in the year assessed and to the induced public costs of their continued education. Estimated benefits are weighed against the total annual public costs of the program, which operates in 65 school centers and commands an annual budget of about $70 million. The estimated benefit-cost ratio for this program is 3 to 1, a figure comparable to benefit-cost ratio estimates reported in studies of dropout prevention. The sensitivity of this conclusion to specific assumptions within the analysis is discussed.

Attributes of Alignment of Real Estate and Facilities Management to Business Needs – an international comparative analysis

DEFF Research Database (Denmark)

Shiem-shin, Danny Then; Tan, Teng-hee; Santovito, Rogerio Fonseca

2014-01-01

Purpose •The purpose of this paper is to present a model for consideration of real estate and facilities management (RE/FM) alignment to business needs and to validate the model based on questionnaire surveys carried out in a number of countries around the world. Design/methodology/approach •The......”, being the most important criteria for the alignment between supply and demand of facility solutions in relation to business needs. One of the main differences in agreement was between the importance of strategy versus cost in the alignment between “facility solutions” and “FM services”. Originality....../value •Alignment of RE/FM to business needs is an essential management task and an important tool for RE/FM executives to create added value to their core business. However, there has so far only been limited research into such an alignment concept applicable to FM and an implementation model....

Novel real-time alignment and calibration of the LHCb detector in Run II

Energy Technology Data Exchange (ETDEWEB)

Xu, Z., E-mail: zhirui.xu@epfl.ch; Tobin, M.

2016-07-11

An automatic real-time alignment and calibration strategy of the LHCb detector was developed for the Run II. Thanks to the online calibration, tighter event selection criteria can be used in the trigger. Furthermore, the online calibration facilitates the use of hadronic particle identification using the Ring Imaging Cherenkov (RICH) detectors at the trigger level. The motivation for a real-time alignment and calibration of the LHCb detector is discussed from both the operational and physics performance points of view. Specific challenges of this novel configuration are discussed, as well as the working procedures of the framework and its performance.

Novel real-time alignment and calibration of the LHCb detector in Run II

CERN Document Server

AUTHOR|(CDS)2086132; Tobin, Mark

2016-01-01

An automatic real-time alignment and calibration strategy of the LHCb detector was developed for the Run II. Thanks to the online calibration, tighter event selection criteria can be used in the trigger. Furthermore, the online calibration facilitates the use of hadronic particle identification using the Ring Imaging Cherenkov (RICH) detectors at the trigger level. The motivation for a real-time alignment and calibration of the LHCb detector is discussed from both the operational and physics performance points of view. Specific challenges of this novel configuration are discussed, as well as the working procedures of the framework and its performance.

Engineering survey planning for the alignment of a particle accelerator: part II. Design of a reference network and measurement strategy

Science.gov (United States)

Junqueira Leão, Rodrigo; Raffaelo Baldo, Crhistian; Collucci da Costa Reis, Maria Luisa; Alves Trabanco, Jorge Luiz

2018-03-01

The building blocks of particle accelerators are magnets responsible for keeping beams of charged particles at a desired trajectory. Magnets are commonly grouped in support structures named girders, which are mounted on vertical and horizontal stages. The performance of this type of machine is highly dependent on the relative alignment between its main components. The length of particle accelerators ranges from small machines to large-scale national or international facilities, with typical lengths of hundreds of meters to a few kilometers. This relatively large volume together with micrometric positioning tolerances make the alignment activity a classical large-scale dimensional metrology problem. The alignment concept relies on networks of fixed monuments installed on the building structure to which all accelerator components are referred. In this work, the Sirius accelerator is taken as a case study, and an alignment network is optimized via computational methods in terms of geometry, densification, and surveying procedure. Laser trackers are employed to guide the installation and measure the girders’ positions, using the optimized network as a reference and applying the metric developed in part I of this paper. Simulations demonstrate the feasibility of aligning the 220 girders of the Sirius synchrotron to better than 0.080 mm, at a coverage probability of 95%.

Living better in Nord-Pas de Calais region. For an energy turn and societal transformations - Full report, Synthesis

International Nuclear Information System (INIS)

2015-12-01

In 2008, the NGO Virage-energie Nord-Pas de Calais published a scenario of nuclear power phaseout including objectives of reduction of green gas emissions in the region of Nord-Pas de Calais. In 2013, Virage-energie Nord-Pas de Calais published Scenarios on energy sufficiency and societal transformations: the results of a research project on the evaluation of energy savings potentials from public policies and lifestyle changes. Using data models and assumptions, this study has highlighted that energy sufficiency could generate energy savings from 26 % to 40 %. Global scenarios presented in this report, realised with the financial support of ADEME and regional council of the region Nord-Pas de Calais in partnership with two academic laboratories (TVES, University of Lille 1 - Science and Technologies; and Ceraps, University of Lille 2 - Health and Law), complete previous works with a global vision for the future energetic and social systems. Scenarios explore interactions between energy, lifestyles, agriculture, food habits, consumer goods, industry, buildings, transport and employment, in order to identify and to reduce human, social, economic and environmental vulnerabilities to energetic crisis. Energy sufficiency and resilience are at the heart of this research. Energy sufficiency is a voluntary and organized strategy to reduce energy consumption through lifestyles changes and societal transformations. Energy sufficiency is different from energy efficiency, which concerns only improvement of technical performances in order to reduce energy consumption of a system (building, vehicle, etc.). Sufficiency re-evaluates uses and needs of energy, but also imaginary and culture of a society and its individual and collective organisations. Resilience is the capacity for a system (territory, population, etc.) to absorb a perturbation, to reorganize itself and to continue to remain in a functionally similar state. Through three possible scenarios for the territory and the

Galaxy Alignments: Theory, Modelling & Simulations

Science.gov (United States)

Kiessling, Alina; Cacciato, Marcello; Joachimi, Benjamin; Kirk, Donnacha; Kitching, Thomas D.; Leonard, Adrienne; Mandelbaum, Rachel; Schäfer, Björn Malte; Sifón, Cristóbal; Brown, Michael L.; Rassat, Anais

2015-11-01

The shapes of galaxies are not randomly oriented on the sky. During the galaxy formation and evolution process, environment has a strong influence, as tidal gravitational fields in the large-scale structure tend to align nearby galaxies. Additionally, events such as galaxy mergers affect the relative alignments of both the shapes and angular momenta of galaxies throughout their history. These "intrinsic galaxy alignments" are known to exist, but are still poorly understood. This review will offer a pedagogical introduction to the current theories that describe intrinsic galaxy alignments, including the apparent difference in intrinsic alignment between early- and late-type galaxies and the latest efforts to model them analytically. It will then describe the ongoing efforts to simulate intrinsic alignments using both N-body and hydrodynamic simulations. Due to the relative youth of this field, there is still much to be done to understand intrinsic galaxy alignments and this review summarises the current state of the field, providing a solid basis for future work.

The CMS Muon System Alignment

CERN Document Server

Martinez Ruiz-Del-Arbol, P

2009-01-01

The alignment of the muon system of CMS is performed using different techniques: photogrammetry measurements, optical alignment and alignment with tracks. For track-based alignment, several methods are employed, ranging from a hit and impact point (HIP) algorithm and a procedure exploiting chamber overlaps to a global fit method based on the Millepede approach. For start-up alignment as long as available integrated luminosity is still significantly limiting the size of the muon sample from collisions, cosmic muon and beam halo signatures play a very strong role. During the last commissioning runs in 2008 the first aligned geometries have been produced and validated with data. The CMS offline computing infrastructure has been used in order to perform improved reconstructions. We present the computational aspects related to the calculation of alignment constants at the CERN Analysis Facility (CAF), the production and population of databases and the validation and performance in the official reconstruction. Also...

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G.Gomez

Since September, the muon alignment system shifted from a mode of hardware installation and commissioning to operation and data taking. All three optical subsystems (Barrel, Endcap and Link alignment) have recorded data before, during and after CRAFT, at different magnetic fields and during ramps of the magnet. This first data taking experience has several interesting goals: •    study detector deformations and movements under the influence of the huge magnetic forces; •    study the stability of detector structures and of the alignment system over long periods, •    study geometry reproducibility at equal fields (specially at 0T and 3.8T); •    reconstruct B=0T geometry and compare to nominal/survey geometries; •    reconstruct B=3.8T geometry and provide DT and CSC alignment records for CMSSW. However, the main goal is to recons...

Relation between film character and wafer alignment: critical alignment issues on HV device for VLSI manufacturing

Science.gov (United States)

Lo, Yi-Chuan; Lee, Chih-Hsiung; Lin, Hsun-Peng; Peng, Chiou-Shian

1998-06-01

Several continuous splits for wafer alignment target topography conditions to improve epitaxy film alignment were applied. The alignment evaluation among former layer pad oxide thickness (250 angstrom - 500 angstrom), drive oxide thickness (6000 angstrom - 10000 angstrom), nitride film thickness (600 angstrom - 1500 angstrom), initial oxide etch (fully wet etch, fully dry etch and dry plus wet etch) will be split to this experiment. Also various epitaxy deposition recipe such as: epitaxy source (SiHCl2 or SiCHCl3) and growth rate (1.3 micrometer/min approximately 2.0 micrometer/min) will be used to optimize the process window for alignment issue. All the reflectance signal and cross section photography of alignment target during NIKON stepper alignment process will be examined. Experimental results show epitaxy recipe plays an important role to wafer alignment. Low growth rate with good performance conformity epitaxy lead to alignment target avoid washout, pattern shift and distortion. All the results (signal monitor and film character) combined with NIKON's stepper standard laser scanning alignment system will be discussed in this paper.

Societal acceptance of carbon capture and storage technologies

International Nuclear Information System (INIS)

Alphen, Klaas van; Voorst tot Voorst, Quirine van; Hekkert, Marko P.; Smits, Ruud E.H.M.

2007-01-01

For the actual implementation of carbon capture and storage (CCS) technologies, societal support is a crucial precondition. This paper describes an extensive study on the acceptance of CCS by stakeholders in the Netherlands and explores one of the determining factors in the acceptance of CCS by the lay public, i.e. the way the Dutch press perceives and portrays CCS. The stakeholder analysis shows that there is a positive attitude towards CCS by industry, government, and environmental NGOs, provided that the conditions they pose on the deployment of CCS are met. The content analysis of Dutch news articles conveys that the media portrayal of CCS is-to a certain extent-a balanced reflection of the way CCS is perceived by the stakeholders. Both analyses show that the concerns about CCS have not overshadowed the main promise that CCS is part of the solution to climate change. However, the current negative aspects of CCS as raised by different stakeholders and the media will remain if no action is taken. Therefore, the conditions posed on the use of CCS, as well as the actions required to meet these conditions, could function as a proxy for the 'societal voice', articulating the most important issues concerning the future acceptance of CCS technology

Nova laser alignment control system

International Nuclear Information System (INIS)

Van Arsdall, P.J.; Holloway, F.W.; McGuigan, D.L.; Shelton, R.T.

1984-01-01

Alignment of the Nova laser requires control of hundreds of optical components in the ten beam paths. Extensive application of computer technology makes daily alignment practical. The control system is designed in a manner which provides both centralized and local manual operator controls integrated with automatic closed loop alignment. Menudriven operator consoles using high resolution color graphics displays overlaid with transport touch panels allow laser personnel to interact efficiently with the computer system. Automatic alignment is accomplished by using image analysis techniques to determine beam references points from video images acquired along the laser chain. A major goal of the design is to contribute substantially to rapid experimental turnaround and consistent alignment results. This paper describes the computer-based control structure and the software methods developed for aligning this large laser system

Self-concept clarity buffers the impact of societal threat to safety on right-wing authoritarianism.

Science.gov (United States)

Russo, Silvia; Manzi, Claudia; Roccato, Michele

2017-01-01

Exposure to societal threat can elicit an increase in right-wing authoritarianism (RWA). In this study, using a quasi-experimental vignette design (Italian community sample, N = 86), we tested the moderating role of self-concept clarity (SCC). A moderated regression showed that manipulated societal threat to safety fostered RWA only among low SCC scorers. It is concluded that SCC is an important resource for individuals facing threat conditions.

pyPaSWAS: Python-based multi-core CPU and GPU sequence alignment.

Science.gov (United States)

Warris, Sven; Timal, N Roshan N; Kempenaar, Marcel; Poortinga, Arne M; van de Geest, Henri; Varbanescu, Ana L; Nap, Jan-Peter

2018-01-01

Our previously published CUDA-only application PaSWAS for Smith-Waterman (SW) sequence alignment of any type of sequence on NVIDIA-based GPUs is platform-specific and therefore adopted less than could be. The OpenCL language is supported more widely and allows use on a variety of hardware platforms. Moreover, there is a need to promote the adoption of parallel computing in bioinformatics by making its use and extension more simple through more and better application of high-level languages commonly used in bioinformatics, such as Python. The novel application pyPaSWAS presents the parallel SW sequence alignment code fully packed in Python. It is a generic SW implementation running on several hardware platforms with multi-core systems and/or GPUs that provides accurate sequence alignments that also can be inspected for alignment details. Additionally, pyPaSWAS support the affine gap penalty. Python libraries are used for automated system configuration, I/O and logging. This way, the Python environment will stimulate further extension and use of pyPaSWAS. pyPaSWAS presents an easy Python-based environment for accurate and retrievable parallel SW sequence alignments on GPUs and multi-core systems. The strategy of integrating Python with high-performance parallel compute languages to create a developer- and user-friendly environment should be considered for other computationally intensive bioinformatics algorithms.

Global health initiatives in Africa - governance, priorities, harmonisation and alignment.

Science.gov (United States)

Mwisongo, Aziza; Nabyonga-Orem, Juliet

2016-07-18

The advent of global health initiatives (GHIs) has changed the landscape and architecture of health financing in low and middle income countries, particularly in Africa. Over the last decade, the African Region has realised improvements in health outcomes as a result of interventions implemented by both governments and development partners. However, alignment and harmonisation of partnerships and GHIs are still difficult in the African countries with inadequate capacity for their effective coordination. Both published and grey literature was reviewed to understand the governance, priorities, harmonisation and alignment of GHIs in the African Region; to synthesise the knowledge and highlight the persistent challenges; and to identify gaps for future research. GHI governance structures are often separate from those of the countries in which they operate. Their divergent funding channels and modalities may have contributed to the failure of governments to track their resources. There is also evidence that basically, earmarking and donor conditions drive funding allocations regardless of countries' priorities. Although studies cite the lack of harmonisation of GHI priorities with national strategies, evidence shows improvements in that area over time. GHIs have used several strategies and mechanisms to involve the private sector. These have widened the pool of health service policy-makers and providers to include groups such as civil society organisations (CSOs), with both positive and negative implications. GHI strategies such as co-financing by countries as a condition for support have been positive in achieving sustainability of interventions. GHI approaches have not changed substantially over the years but there has been evolution in terms of donor funding and conditions. GHIs still largely operate in a vertical manner, bypassing country systems; they compete for the limited human resources; they influence country policies; and they are not always harmonised with

Management as a science-based profession: a grand societal challenge

NARCIS (Netherlands)

Romme, A.G.L.

2017-01-01

The purpose of this paper is to explore how the quest for management as a science-based profession, conceived as a grand societal challenge, can be revitalized. A reflective approach is adopted by questioning some of the key assumptions made by management scholars, especially those that undermine

Novas mediações societárias entre o público e o privado

Directory of Open Access Journals (Sweden)

Rotta, Edemar

2003-01-01

Full Text Available A crise do capitalismo e do socialismo real, no final do século vinte, desencadeia uma rediscussão a respeito de novos projetos societários. Retoma-se a reflexão em torno dos fundamentos da modernidade, procurando compreender as bases em que foram construídos os “modelos” societários e que problemas apresentaram em seu processo de implementação prática. Essa reflexão demonstra os limites do projeto moderno e evoca os diversos atores sociais a explicitarem suas propostas de organização societária a partir dos condicionantes que vivem em suas realidades concretas e das possibilidades que possuem. Esse texto procura apresentar alguns aspectos de como ocorre essa reflexão na Fronteira Noroeste do Estado do Rio Grande do Sul, que vive um momento importante de discussão a respeito de suas possibilidades de desenvolvimento

Societal costs of home and hospital end-of-life care for palliative care patients in Ontario, Canada.

Science.gov (United States)

Yu, Mo; Guerriere, Denise N; Coyte, Peter C

2015-11-01

In Canada, health system restructuring has led to a greater focus on home-based palliative care as an alternative to institutionalised palliative care. However, little is known about the effect of this change on end-of-life care costs and the extent to which the financial burden of care has shifted from the acute care public sector to families. The purpose of this study was to assess the societal costs of end-of-life care associated with two places of death (hospital and home) using a prospective cohort design in a home-based palliative care programme. Societal cost includes all costs incurred during the course of palliative care irrespective of payer (e.g. health system, out-of-pocket, informal care-giving costs, etc.). Primary caregivers of terminal cancer patients were recruited from the Temmy Latner Centre for Palliative Care in Toronto, Canada. Demographic, service utilisation, care-giving time, health and functional status, and death data were collected by telephone interviews with primary caregivers over the course of patients' palliative trajectory. Logistic regression was conducted to model an individual's propensity for home death. Total societal costs of end-of-life care and component costs were compared between home and hospital death using propensity score stratification. Costs were presented in 2012 Canadian dollars ($1.00 CDN = $1.00 USD). The estimated total societal cost of end-of-life care was $34,197.73 per patient over the entire palliative trajectory (4 months on average). Results showed no significant difference (P > 0.05) in total societal costs between home and hospital death patients. Higher hospitalisation costs for hospital death patients were replaced by higher unpaid caregiver time and outpatient service costs for home death patients. Thus, from a societal cost perspective, alternative sites of death, while not associated with a significant change in total societal cost of end-of-life care, resulted in changes in the distribution of

Cultural estrangement: the role of personal and societal value discrepancies.

Science.gov (United States)

Bernard, Mark M; Gebauer, Jochen E; Maio, Gregory R

2006-01-01

Study 1 examined whether cultural estrangement arises from discrepancies between personal and societal values (e.g., freedom) rather than from discrepancies in attitudes toward political (e.g., censorship) or mundane (e.g., pizza) objects. The relations between different types of value discrepancies, estrangement, subjective well-being, and need for uniqueness also were examined. Results indicated that personal-societal discrepancies in values and political attitudes predicted estrangement, whereas mundane attitude discrepancies were not related to estrangement. As expected, value discrepancies were the most powerful predictor of estrangement. Value discrepancies were not related to subjective well-being but fulfilled a need for uniqueness. Study 2 replicated the relations between value discrepancies, subjective well-being, and need for uniqueness while showing that a self-report measure of participants' values and a peer-report measure of the participants' values yielded the same pattern of value discrepancies. Together, the studies reveal theoretical and empirical benefits of conceptualizing cultural estrangement in terms of value discrepancies.

MUON DETECTORS: ALIGNMENT

CERN Multimedia

G. Gomez and Y. Pakhotin

2012-01-01

  A new track-based alignment for the DT chambers is ready for deployment: an offline tag has already been produced which will become part of the 52X Global Tag. This alignment was validated within the muon alignment group both at low and high momentum using a W/Z skim sample. It shows an improved mass resolution for pairs of stand-alone muons, improved curvature resolution at high momentum, and improved DT segment extrapolation residuals. The validation workflow for high-momentum muons used to depend solely on the “split cosmics” method, looking at the curvature difference between muon tracks reconstructed in the upper or lower half of CMS. The validation has now been extended to include energetic muons decaying from heavily boosted Zs: the di-muon invariant mass for global and stand-alone muons is reconstructed, and the invariant mass resolution is compared for different alignments. The main areas of development over the next few months will be preparing a new track-based C...

High Religiosity and Societal Dysfunction in the United States during the First Decade of the Twenty-First Century

Directory of Open Access Journals (Sweden)

R. Georges Delamontagne

2010-10-01

Full Text Available This study provides independent empirical evidence that bears upon the truth or falsity of recently formulated hypotheses regarding reciprocal relationships between levels of religiosity and societal dysfunction. Gregory S. Paul's findings, published in the Journal of Religion and Society (2005, Free Inquiry (2008, and Evolutionary Psychology (2009, have demonstrated that high degrees of theism are associated with high degrees of societal dysfunction among the prosperous democracies. Whereas his research employs numerous scatter diagrams and bivariate correlations involving measures of religiosity and societal dysfunction pertaining to 17 nation states, the current study's units of analysis are the 50 states and the District of Columbia. Additionally, the utilization of multiple regression analysis allows the detection of the effects of other potentially relevant explanatory variables, such as educational attainment, income level, and race. The findings are only minimally supportive of Paul's hypotheses regarding the contributions of high religiosity to societal dysfunction and to the effects of societal dysfunction upon religiosity. Simultaneously, the results of correlational and regression analyses attest to the more substantial explanatory power of the social inequality variables of education, income, and race. Accordingly, it is argued that “American Exceptionalism,” when understood as referring to a society manifesting the coexistence of high levels of theism and high levels of societal dysfunction, is best explained by the United States' high degree of social inequality, compared with other modern industrialized democracies.

Alignment of the ATLAS Inner Detector upgraded for the LHC Run II

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00386283; The ATLAS collaboration

2015-01-01

ATLAS is a multipurpose experiment at the LHC proton-proton collider. Its physics goals require high resolution, unbiased measurement of all charged particle kinematic parameters. These critically depend on the layout and performance of the tracking system, notably quality of its offline alignment. ATLAS is equipped with a tracking system built using different technologies, silicon planar sensors (pixel and micro-strip) and gaseous drift- tubes, all embedded in a 2T solenoidal magnetic field. For the LHC Run II, the system has been upgraded with the installation of a new pixel layer, the Insertable B-layer (IBL). Offline track alignment of the ATLAS tracking system has to deal with about 700,000 degrees of freedom (DoF) defining its geometrical parameters. The task requires using very large data sets and represents a considerable numerical challenge in terms of both CPU time and precision. The adopted strategy uses a hierarchical approach to alignment, combining local and global least squares techniques. An o...

Alignment of the ATLAS Inner Detector Upgraded for the LHC Run II

CERN Document Server

Butti, Pierfrancesco; The ATLAS collaboration

2015-01-01

ATLAS is a multipurpose experiment at the LHC proton-proton collider. Its physics goals require high resolution, unbiased measurement of all charged particle kinematic parameters. These critically depend on the layout and performance of the tracking system, notably quality of its offline alignment. ATLAS is equipped with a tracking system built using different technologies, silicon planar sensors (pixel and micro-strip) and gaseous drift- tubes, all embedded in a 2T solenoidal magnetic field. For the LHC Run II, the system has been upgraded with the installation of a new pixel layer, the Insertable B-layer (IBL). Offline track alignment of the ATLAS tracking system has to deal with about 700,000 degrees of freedom (DoF) defining its geometrical parameters. The task requires using very large data sets and represents a considerable numerical challenge in terms of both CPU time and precision. The adopted strategy uses a hierarchical approach to alignment, combining local and global least squares techniques. An o...

Evaluating Performance: Strategic Alignment and Productivity

Directory of Open Access Journals (Sweden)

Armando Cuesta Santos

2012-10-01

Full Text Available Actually is reported as a world problem to enterprise label the rupture or inexistence of the connections between the strategy, human resource management and the organizational management indicators. In the Cuban enterprise practice this is manifest too. Surpass this rupture on the technical and organizer plan, is the principal objective of this research. In this paper is argument one methodological process that begins with the definition of labour competency to consider into post profiles, that conduced to surpass the actual rupture or opposition (versus, or not alignment or not integration, between the performance individual appraisal and the performance organizational strategic appraisal.

R3D Align web server for global nucleotide to nucleotide alignments of RNA 3D structures.

Science.gov (United States)

Rahrig, Ryan R; Petrov, Anton I; Leontis, Neocles B; Zirbel, Craig L

2013-07-01

The R3D Align web server provides online access to 'RNA 3D Align' (R3D Align), a method for producing accurate nucleotide-level structural alignments of RNA 3D structures. The web server provides a streamlined and intuitive interface, input data validation and output that is more extensive and easier to read and interpret than related servers. The R3D Align web server offers a unique Gallery of Featured Alignments, providing immediate access to pre-computed alignments of large RNA 3D structures, including all ribosomal RNAs, as well as guidance on effective use of the server and interpretation of the output. By accessing the non-redundant lists of RNA 3D structures provided by the Bowling Green State University RNA group, R3D Align connects users to structure files in the same equivalence class and the best-modeled representative structure from each group. The R3D Align web server is freely accessible at http://rna.bgsu.edu/r3dalign/.

Aligned Layers of Silver Nano-Fibers

Directory of Open Access Journals (Sweden)

Andrii B. Golovin

2012-02-01

Full Text Available We describe a new dichroic polarizers made by ordering silver nano-fibers to aligned layers. The aligned layers consist of nano-fibers and self-assembled molecular aggregates of lyotropic liquid crystals. Unidirectional alignment of the layers is achieved by means of mechanical shearing. Aligned layers of silver nano-fibers are partially transparent to a linearly polarized electromagnetic radiation. The unidirectional alignment and density of the silver nano-fibers determine degree of polarization of transmitted light. The aligned layers of silver nano-fibers might be used in optics, microwave applications, and organic electronics.

Radiation technology in ground nut improvement and societal deployment

International Nuclear Information System (INIS)

Murty, G.S.S.; Badigannavar, A.M.; Kale, D.M.

2004-01-01

The best way to summarize the impact of mutation research in ground nut for societal deployment is for 1) developing suitable varieties for different agro-climatic zones in the country, 2) providing a source material for developing new varieties by other universities, 3) replacing traditional crops with TG varieties, 4) transforming socioeconomic status of peanut peasants and 5) enhanced ground nut productivity

Societal perspective on the burden of migraine in The Netherlands

NARCIS (Netherlands)

van Roijen, L.; Essink-Bot, M. L.; Koopmanschap, M. A.; Michel, B. C.; Rutten, F. F.

1995-01-01

This study presents a comprehensive overview of the societal burden of migraine in The Netherlands. We assessed the direct and indirect costs of this disease, and the health status of patients with migraine. We developed the 'illness and labour' (I&L) questionnaire to collect data on the effect of

Character and Citizenship Education: Conversations between Personal and Societal Values

Science.gov (United States)

Sim, Jasmine B.-Y.; Low, Ee Ling

2012-01-01

The theme of this special issue is "Character and Citizenship Education: Conversations between Personal and Societal Values." Character education and citizenship education, taken separately or as a single entity are currently riding high on the political and educational policy agendas of several governments (Arthur, 2003; Berkowitz & Bier, 2007;…

In Defense of Societal Issues as Organizers for School Science.

Science.gov (United States)

Yager, Robert E.

1983-01-01

Offers a defense of societal issues as organizers for school science programs in response to criticisms of this thesis discussed in SE 534 649. Indicates that there appears to be no evidence that using nontraditional topics as organizers will make science more subject to manipulation and perversion. (JN)

Heat-Treatment-Responsive Proteins in Different Developmental Stages of Tomato Pollen Detected by Targeted Mass Accuracy Precursor Alignment (tMAPA).

Science.gov (United States)

Chaturvedi, Palak; Doerfler, Hannes; Jegadeesan, Sridharan; Ghatak, Arindam; Pressman, Etan; Castillejo, Maria Angeles; Wienkoop, Stefanie; Egelhofer, Volker; Firon, Nurit; Weckwerth, Wolfram

2015-11-06

Recently, we have developed a quantitative shotgun proteomics strategy called mass accuracy precursor alignment (MAPA). The MAPA algorithm uses high mass accuracy to bin mass-to-charge (m/z) ratios of precursor ions from LC-MS analyses, determines their intensities, and extracts a quantitative sample versus m/z ratio data alignment matrix from a multitude of samples. Here, we introduce a novel feature of this algorithm that allows the extraction and alignment of proteotypic peptide precursor ions or any other target peptide from complex shotgun proteomics data for accurate quantification of unique proteins. This strategy circumvents the problem of confusing the quantification of proteins due to indistinguishable protein isoforms by a typical shotgun proteomics approach. We applied this strategy to a comparison of control and heat-treated tomato pollen grains at two developmental stages, post-meiotic and mature. Pollen is a temperature-sensitive tissue involved in the reproductive cycle of plants and plays a major role in fruit setting and yield. By LC-MS-based shotgun proteomics, we identified more than 2000 proteins in total for all different tissues. By applying the targeted MAPA data-processing strategy, 51 unique proteins were identified as heat-treatment-responsive protein candidates. The potential function of the identified candidates in a specific developmental stage is discussed.

Resilient Grid Operational Strategies

Energy Technology Data Exchange (ETDEWEB)

Pasqualini, Donatella [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-03-01

Extreme weather-related disturbances, such as hurricanes, are a leading cause of grid outages historically. Although physical asset hardening is perhaps the most common way to mitigate the impacts of severe weather, operational strategies may be deployed to limit the extent of societal and economic losses associated with weather-related physical damage.1 The purpose of this study is to examine bulk power-system operational strategies that can be deployed to mitigate the impact of severe weather disruptions caused by hurricanes, thereby increasing grid resilience to maintain continuity of critical infrastructure during extreme weather. To estimate the impacts of resilient grid operational strategies, Los Alamos National Laboratory (LANL) developed a framework for hurricane probabilistic risk analysis (PRA). The probabilistic nature of this framework allows us to estimate the probability distribution of likely impacts, as opposed to the worst-case impacts. The project scope does not include strategies that are not operations related, such as transmission system hardening (e.g., undergrounding, transmission tower reinforcement and substation flood protection) and solutions in the distribution network.

Alignment of CEBAF cryomodules

International Nuclear Information System (INIS)

Schneider, W.J.; Bisognano, J.J.; Fischer, J.

1993-06-01

CEBAF, the Continuous Electron Beam Accelerator Facility, when completed, will house a 4 GeV recirculating accelerator. Each of the accelerator's two linacs contains 160 superconducting radio frequency (SRF) 1497 MHz niobium cavities in 20 cryomodules. Alignments of the cavities within the cryomodule with respect to beam axis is critical to achieving the optimum accelerator performance. This paper discusses the rationale for the current specification on cavity mechanical alignment: 2 mrad (rms) applied to the 0.5 m active length cavities. We describe the tooling that was developed to achieve the tolerance at the time of cavity pair assembly, to preserve and integrate alignment during cryomodule assembly, and to translate alignment to appropriate installation in the beam line

Micropatterning stretched and aligned DNA for sequence-specific nanolithography

Science.gov (United States)

Petit, Cecilia Anna Paulette

Techniques for fabricating nanostructured materials can be categorized as either "top-down" or "bottom-up". Top-down techniques use lithography and contact printing to create patterned surfaces and microfluidic channels that can corral and organize nanoscale structures, such as molecules and nanorods in contrast; bottom-up techniques use self-assembly or molecular recognition to direct the organization of materials. A central goal in nanotechnology is the integration of bottom-up and top-down assembly strategies for materials development, device design; and process integration. With this goal in mind, we have developed strategies that will allow this integration by using DNA as a template for nanofabrication; two top-down approaches allow the placement of these templates, while the bottom-up technique uses the specific sequence of bases to pattern materials along each strand of DNA. Our first top-down approach, termed combing of molecules in microchannels (COMMIC), produces microscopic patterns of stretched and aligned molecules of DNA on surfaces. This process consists of passing an air-water interface over end adsorbed molecules inside microfabricated channels. The geometry of the microchannel directs the placement of the DNA molecules, while the geometry of the airwater interface directs the local orientation and curvature of the molecules. We developed another top-down strategy for creating micropatterns of stretched and aligned DNA using surface chemistry. Because DNA stretching occurs on hydrophobic surfaces, this technique uses photolithography to pattern vinyl-terminated silanes on glass When these surface-, are immersed in DNA solution, molecules adhere preferentially to the silanized areas. This approach has also proven useful in patterning protein for cell adhesion studies. Finally, we describe the use of these stretched and aligned molecules of DNA as templates for the subsequent bottom-up construction of hetero-structures through hybridization

Societal acceptance of wind farms: Analysis of four common themes across Australian case studies

International Nuclear Information System (INIS)

Hall, N.; Ashworth, P.; Devine-Wright, P.

2013-01-01

Australia's renewable energy target (RET) seeks to provide 20 per cent of Australia's electricity generation from renewable energy sources by 2020. As wind power is relatively advanced, it was anticipated that wind power will contribute a major component of the early target. However, high levels of societal resistance to wind farms, combined with new regulatory policies, indicate the RET may not be dominated by wind power. This research involved an examination of seven case studies around wind farm deployment. Qualitative interviews were the primary data for the case studies and analysed using methods informed by grounded theory. Despite the diversity of stakeholder views, the qualitative analysis identified strong community support for wind farms but four common themes emerged that influence this societal acceptance of wind farms in Australia: trust, distributional justice, procedural justice and place attachment. Without addressing these factors through integration into policy development and engagement approaches, wind energy is unlikely to provide the early and majority of new renewable energy. Similar international experiences are incorporated in the discussion of the Australian wind industry's societal acceptance. - Highlights: ► Seven case studies of wind farms in Australia are described. ► Acceptance affects whether wind significantly contributes to the Aust. RE target. ► Four themes were identified regarding societal acceptance of Australian wind farms. ► Four themes are trust, distributional and procedural justice, and place attachment. ► International similarities to the Australian experience are provided

Physician-Hospital Alignment in Orthopedic Surgery.

Science.gov (United States)

Bushnell, Brandon D

2015-09-01

The concept of "alignment" between physicians and hospitals is a popular buzzword in the age of health care reform. Despite their often tumultuous histories, physicians and hospitals find themselves under increasing pressures to work together toward common goals. However, effective alignment is more than just simple cooperation between parties. The process of achieving alignment does not have simple, universal steps. Alignment will differ based on individual situational factors and the type of specialty involved. Ultimately, however, there are principles that underlie the concept of alignment and should be a part of any physician-hospital alignment efforts. In orthopedic surgery, alignment involves the clinical, administrative, financial, and even personal aspects of a surgeon's practice. It must be based on the principles of financial interest, clinical authority, administrative participation, transparency, focus on the patient, and mutual necessity. Alignment can take on various forms as well, with popular models consisting of shared governance and comanagement, gainsharing, bundled payments, accountable care organizations, and other methods. As regulatory and financial pressures continue to motivate physicians and hospitals to develop alignment relationships, new and innovative methods of alignment will also appear. Existing models will mature and evolve, with individual variability based on local factors. However, certain trends seem to be appearing as time progresses and alignment relationships deepen, including regional and national collaboration, population management, and changes in the legal system. This article explores the history, principles, and specific methods of physician-hospital alignment and its critical importance for the future of health care delivery. Copyright 2015, SLACK Incorporated.

Alignment Condition-Based Robust Adaptive Iterative Learning Control of Uncertain Robot System

Directory of Open Access Journals (Sweden)

Guofeng Tong

2014-04-01

Full Text Available This paper proposes an adaptive iterative learning control strategy integrated with saturation-based robust control for uncertain robot system in presence of modelling uncertainties, unknown parameter, and external disturbance under alignment condition. An important merit is that it achieves adaptive switching of gain matrix both in conventional PD-type feedforward control and robust adaptive control in the iteration domain simultaneously. The analysis of convergence of proposed control law is based on Lyapunov's direct method under alignment initial condition. Simulation results demonstrate the faster learning rate and better robust performance with proposed algorithm by comparing with other existing robust controllers. The actual experiment on three-DOF robot manipulator shows its better practical effectiveness.

Economic analysis of pandemic influenza mitigation strategies for five pandemic severity categories

Science.gov (United States)

2013-01-01

Background The threat of emergence of a human-to-human transmissible strain of highly pathogenic influenza A(H5N1) is very real, and is reinforced by recent results showing that genetically modified A(H5N1) may be readily transmitted between ferrets. Public health authorities are hesitant in introducing social distancing interventions due to societal disruption and productivity losses. This study estimates the effectiveness and total cost (from a societal perspective, with a lifespan time horizon) of a comprehensive range of social distancing and antiviral drug strategies, under a range of pandemic severity categories. Methods An economic analysis was conducted using a simulation model of a community of ~30,000 in Australia. Data from the 2009 pandemic was used to derive relationships between the Case Fatality Rate (CFR) and hospitalization rates for each of five pandemic severity categories, with CFR ranging from 0.1% to 2.5%. Results For a pandemic with basic reproduction number R0 = 1.8, adopting no interventions resulted in total costs ranging from $441 per person for a pandemic at category 1 (CFR 0.1%) to $8,550 per person at category 5 (CFR 2.5%). For severe pandemics of category 3 (CFR 0.75%) and greater, a strategy combining antiviral treatment and prophylaxis, extended school closure and community contact reduction resulted in the lowest total cost of any strategy, costing $1,584 per person at category 5. This strategy was highly effective, reducing the attack rate to 5%. With low severity pandemics costs are dominated by productivity losses due to illness and social distancing interventions, whereas higher severity pandemic costs are dominated by healthcare costs and costs arising from productivity losses due to death. Conclusions For pandemics in high severity categories the strategies with the lowest total cost to society involve rigorous, sustained social distancing, which are considered unacceptable for low severity pandemics due to societal

The CMS Silicon Tracker Alignment

CERN Document Server

Castello, R

2008-01-01

The alignment of the Strip and Pixel Tracker of the Compact Muon Solenoid experiment, with its large number of independent silicon sensors and its excellent spatial resolution, is a complex and challenging task. Besides high precision mounting, survey measurements and the Laser Alignment System, track-based alignment is needed to reach the envisaged precision.\\\\ Three different algorithms for track-based alignment were successfully tested on a sample of cosmic-ray data collected at the Tracker Integration Facility, where 15\\% of the Tracker was tested. These results, together with those coming from the CMS global run, will provide the basis for the full-scale alignment of the Tracker, which will be carried out with the first \\emph{p-p} collisions.

Taking a Societal Sector Perspective on Youth Learning and Development

Science.gov (United States)

McLaughlin, Milbrey; London, Rebecca A.

2013-01-01

A societal sector perspective looks to a broad array of actors and agencies responsible for creating the community contexts that affect youth learning and development. We demonstrate the efficacy of this perspective by describing the Youth Data Archive, which allows community partners to define issues affecting youth that transcend specific…

Unified Alignment of Protein-Protein Interaction Networks.

Science.gov (United States)

Malod-Dognin, Noël; Ban, Kristina; Pržulj, Nataša

2017-04-19

Paralleling the increasing availability of protein-protein interaction (PPI) network data, several network alignment methods have been proposed. Network alignments have been used to uncover functionally conserved network parts and to transfer annotations. However, due to the computational intractability of the network alignment problem, aligners are heuristics providing divergent solutions and no consensus exists on a gold standard, or which scoring scheme should be used to evaluate them. We comprehensively evaluate the alignment scoring schemes and global network aligners on large scale PPI data and observe that three methods, HUBALIGN, L-GRAAL and NATALIE, regularly produce the most topologically and biologically coherent alignments. We study the collective behaviour of network aligners and observe that PPI networks are almost entirely aligned with a handful of aligners that we unify into a new tool, Ulign. Ulign enables complete alignment of two networks, which traditional global and local aligners fail to do. Also, multiple mappings of Ulign define biologically relevant soft clusterings of proteins in PPI networks, which may be used for refining the transfer of annotations across networks. Hence, PPI networks are already well investigated by current aligners, so to gain additional biological insights, a paradigm shift is needed. We propose such a shift come from aligning all available data types collectively rather than any particular data type in isolation from others.

Multi-level influences on childhood obesity in Sweden: societal factors, parental determinants and child's lifestyle.

Science.gov (United States)

Moraeus, L; Lissner, L; Yngve, A; Poortvliet, E; Al-Ansari, U; Sjöberg, A

2012-07-01

Swedish school children living in rural areas and in areas with low education are at excess risk of becoming overweight. This study examines influences of societal and individual characteristics (children and their parents) on prevalence of overweight and obesity, in a national sample of 7-9-year-old children. Anthropometric and lifestyle data were collected in a nationally representative sample of 3636 Swedish children. Overweight and obesity (International Obesity Task Force (IOTF)) data were analyzed in relation to lifestyle factors, parental weight, education and breast-feeding. The prevalence of overweight was 15.6% including 2.6% obese. Urbanization level and parental characteristics (weight status and education) were related to risk of overweight. Overall less favorable lifestyle characteristics were observed in rural areas and for children of low/medium educated mothers. Boys had greater risk of obesity in semi-urban and rural areas but this was not true for girls. For children's overweight, the living area effect was attenuated in multivariate analysis, while there was an association with origin of parents, high parental weight and medium maternal education. For obesity, the living area effect remained in boys while having two non-Nordic parents predicted obesity in girls. Parental weight status was associated with obesity in both girls and boys. Individual and societal factors influence children's weight status, and parental weight status is a strong determinant. Including overweight and obese parents in future health promoting interventions could be a strategy to prevent children from becoming overweight, but identifying those parents may prove difficult. To ensure reaching children with the greatest needs, targeting high risk areas might be a more effective approach.

Analysis of Water Conflicts across Natural and Societal Boundaries: Integration of Quantitative Modeling and Qualitative Reasoning

Science.gov (United States)

Gao, Y.; Balaram, P.; Islam, S.

2009-12-01

Water issues and problems have bewildered humankind for a long time yet a systematic approach for understanding such issues remain elusive. This is partly because many water-related problems are framed from a contested terrain in which many actors (individuals, communities, businesses, NGOs, states, and countries) compete to protect their own and often conflicting interests. We argue that origin of many water problems may be understood as a dynamic consequence of competition, interconnections, and feedback among variables in the Natural and Societal Systems (NSSs). Within the natural system, we recognize that triple constraints on water- water quantity (Q), water quality (P), and ecosystem (E)- and their interdependencies and feedback may lead to conflicts. Such inherent and multifaceted constraints of the natural water system are exacerbated often at the societal boundaries. Within the societal system, interdependencies and feedback among values and norms (V), economy (C), and governance (G) interact in various ways to create intractable contextual differences. The observation that natural and societal systems are linked is not novel. Our argument here, however, is that rigid disciplinary boundaries between these two domains will not produce solutions to the water problems we are facing today. The knowledge needed to address water problems need to go beyond scientific assessment in which societal variables (C, G, and V) are treated as exogenous or largely ignored, and policy research that does not consider the impact of natural variables (E, P, and Q) and that coupling among them. Consequently, traditional quantitative methods alone are not appropriate to address the dynamics of water conflicts, because we cannot quantify the societal variables and the exact mathematical relationships among the variables are not fully known. On the other hand, conventional qualitative study in societal domain has mainly been in the form of individual case studies and therefore

Precision alignment device

Science.gov (United States)

Jones, N.E.

1988-03-10

Apparatus for providing automatic alignment of beam devices having an associated structure for directing, collimating, focusing, reflecting, or otherwise modifying the main beam. A reference laser is attached to the structure enclosing the main beam producing apparatus and produces a reference beam substantially parallel to the main beam. Detector modules containing optical switching devices and optical detectors are positioned in the path of the reference beam and are effective to produce an electrical output indicative of the alignment of the main beam. This electrical output drives servomotor operated adjustment screws to adjust the position of elements of the structure associated with the main beam to maintain alignment of the main beam. 5 figs.

Curricular Alignment: A Re-examination.

Science.gov (United States)

Anderson, Lorin W.

2002-01-01

Examines key differences among content coverage, opportunity to learn, and curriculum alignment, suggesting that the revised Taxonomy provides a framework for analyzing curriculum alignment and illustrating how the Taxonomy Table can be used to estimate curriculum alignment. The paper notes that the revised Taxonomy enables educators to probe…

Developing and Testing a Method to Measure Academic Societal Impact

Science.gov (United States)

Phillips, Paul; Moutinho, Luiz; Godinho, Pedro

2018-01-01

This paper aims to extend understanding of the business and societal impact of academic research. From a business school perspective, it has taken stock of the role of academic research and relevance in business and society. The proposed conceptual framework highlights the forces influencing the pursuit of academic rigour and relevance in…

Spatial Updating Strategy Affects the Reference Frame in Path Integration.

Science.gov (United States)

He, Qiliang; McNamara, Timothy P

2018-06-01

This study investigated how spatial updating strategies affected the selection of reference frames in path integration. Participants walked an outbound path consisting of three successive waypoints in a featureless environment and then pointed to the first waypoint. We manipulated the alignment of participants' final heading at the end of the outbound path with their initial heading to examine the adopted reference frame. We assumed that the initial heading defined the principal reference direction in an allocentric reference frame. In Experiment 1, participants were instructed to use a configural updating strategy and to monitor the shape of the outbound path while they walked it. Pointing performance was best when the final heading was aligned with the initial heading, indicating the use of an allocentric reference frame. In Experiment 2, participants were instructed to use a continuous updating strategy and to keep track of the location of the first waypoint while walking the outbound path. Pointing performance was equivalent regardless of the alignment between the final and the initial headings, indicating the use of an egocentric reference frame. These results confirmed that people could employ different spatial updating strategies in path integration (Wiener, Berthoz, & Wolbers Experimental Brain Research 208(1) 61-71, 2011), and suggested that these strategies could affect the selection of the reference frame for path integration.

Quality improvement education to improve performance on ulcerative colitis quality measures and care processes aligned with National Quality Strategy priorities.

Science.gov (United States)

Greene, Laurence; Moreo, Kathleen

2015-01-01

Studies on inflammatory bowel disease (IBD) have reported suboptimal approaches to patient care. In the United States, the findings have motivated leading gastroenterology organizations to call for initiatives that support clinicians in aligning their practices with quality measures for IBD and priorities of the National Quality Strategy (NQS). We designed and implemented a quality improvement (QI) education program on ulcerative colitis in which patient charts were audited for 30 gastroenterologists before (n = 300 charts) and after (n = 290 charts) they participated in QI-focused educational activities. Charts were audited for nine measures, selected for their alignment with four NQS priorities: making care safer, ensuring patient engagement, promoting communication, and promoting effective treatment practices. Four of the measures, including guideline-directed vaccinations and assessments of disease type and activity, were part of the CMS Physician Quality Reporting System (PQRS). The other five measures involved counseling patients on various topics in ulcerative colitis management, documentation of side effects, assessment of adherence status, and simplification of dosing. The gastroenterologists also completed baseline and post-education surveys designed to assess qualitative outcomes. One of the educational interventions was a private audit feedback session conducted for each gastroenterologist. The sessions were designed to support participants in identifying measures reflecting suboptimal care quality and developing action plans for improvement. In continuous improvement cycles, follow-up interventions included QI tools and educational monographs. Across the nine chart variables, post-education improvements ranged from 0% to 48%, with a mean improvement of 15.9%. Survey findings revealed improvements in self-reported understanding of quality measures and intentions to apply them to practice, and lower rates of perceived significant barriers to high

Interactive software tool to comprehend the calculation of optimal sequence alignments with dynamic programming.

Science.gov (United States)

Ibarra, Ignacio L; Melo, Francisco

2010-07-01

Dynamic programming (DP) is a general optimization strategy that is successfully used across various disciplines of science. In bioinformatics, it is widely applied in calculating the optimal alignment between pairs of protein or DNA sequences. These alignments form the basis of new, verifiable biological hypothesis. Despite its importance, there are no interactive tools available for training and education on understanding the DP algorithm. Here, we introduce an interactive computer application with a graphical interface, for the purpose of educating students about DP. The program displays the DP scoring matrix and the resulting optimal alignment(s), while allowing the user to modify key parameters such as the values in the similarity matrix, the sequence alignment algorithm version and the gap opening/extension penalties. We hope that this software will be useful to teachers and students of bioinformatics courses, as well as researchers who implement the DP algorithm for diverse applications. The software is freely available at: http:/melolab.org/sat. The software is written in the Java computer language, thus it runs on all major platforms and operating systems including Windows, Mac OS X and LINUX. All inquiries or comments about this software should be directed to Francisco Melo at fmelo@bio.puc.cl.

Geodetic alignment of laser power installations

International Nuclear Information System (INIS)

Shtorm, V.V.; Gostev, A.M.; Drobikov, A.V.

1989-01-01

Main problems occuring in applied geodesy under initial alignment of laser power installation optical channel are considered. Attention is paid to alignment of lens beamguide telescopic pairs and alignment quality control. Methods and means of geodetic measurements under alignment are indicated. Conclusions are made about the degree of working through certain aspects of the problem

Alignment of global supply networks based on strategic groups of supply chains

Directory of Open Access Journals (Sweden)

Nikos G. Moraitakis

2017-09-01

Full Text Available Background: From a supply chain perspective, often big differences exist between global raw material suppliers’ approaches to supply their respective local markets. The progressing complexity of large centrally managed global supply networks and their often-unknown upstream ramifications increase the likelihood of undetected bottlenecks and inefficiencies. It is therefore necessary to develop an approach to strategically master the upstream complexity of such networks from a holistic supply chain perspective in order to align regional competitive priorities and supply chain structures. The objective of this research is hence to develop an approach for the supply-chain-based alignment of complex global supply networks. Method: We review existing literature from the fields of supply chain and network management, strategic sourcing, and strategic management. Based on the literature review and theoretical and practical considerations we deduce a conceptual approach to consider upstream supply chain structures in supply network alignment initiatives. Results: On the basis of these considerations and current empirical literature we transfer strategic group theory to the supply network management context. The proposed approach introduces strategic groups of supply chains as a segmentation criterion for complex global supply networks which enables the network-wide alignment of competitive priorities. Conclusion: Supply-chain-based segmentation of global supply network structures can effectively reduce the complexity, firms face when aiming to strategically align their supply chains on a holistic level. The results of this research are applicable for certain types of global supply networks and can be used for network alignment and strategy development. The approach can furthermore generate insights useable for negotiation support with suppliers.

Astrobiology, discovery, and societal impact

CERN Document Server

Dick, Steven J

2018-01-01

The search for life in the universe, once the stuff of science fiction, is now a robust worldwide research program with a well-defined roadmap probing both scientific and societal issues. This volume examines the humanistic aspects of astrobiology, systematically discussing the approaches, critical issues, and implications of discovering life beyond Earth. What do the concepts of life and intelligence, culture and civilization, technology and communication mean in a cosmic context? What are the theological and philosophical implications if we find life - and if we do not? Steven J. Dick argues that given recent scientific findings, the discovery of life in some form beyond Earth is likely and so we need to study the possible impacts of such a discovery and formulate policies to deal with them. The remarkable and often surprising results are presented here in a form accessible to disciplines across the sciences, social sciences, and humanities.

Preservation of Agricultural Land as an Issue of Societal Importance

Directory of Open Access Journals (Sweden)

Elin Slätmo

2017-12-01

Full Text Available Based on concerns about food security and food sovereignty, it is appropriate to scrutinise societal measures for protecting agricultural land from conversion to other uses. Changes from agricultural to urban land use are particularly problematic, as they are largely irreversible. By analysing relevant Swedish policy, the present study investigated how the protection of agricultural land is framed as an issue of societal importance. Protection of agricultural land is enshrined in Swedish law, but its use is still continually changing to housing and other constructions. In a structured policy analysis, two questions were examined: (1 what are the societal motives for protecting agricultural land in Sweden, and (2 how do these motives influence the governance of agricultural land? The meaning of ‘national importance’, ‘suitable for cultivation’ and ‘significant national interests’ in Swedish land-use law was also analysed. The results showed that formulations in the law reflect the ambivalent discourses on agricultural land preservation and that the Swedish authorities view other land uses as more important than agriculture. The Swedish governance system is currently built on trust that municipal institutions will make satisfactory decisions concerning land and water use. However, it has been shown that these decisions have not been satisfactory concerning the protection of agricultural land, and it is important to acknowledge that the sum of local decisions can be degrading for these life-supporting resources. The present analysis revealed a looming conflict between the preservation of soils for food production, on one hand, and local participation in decision making, on the other. This raises the question of whether it is more important to defend subsidiarity or to preserve certain resources which are important for food security, such as agricultural land.

Fairness hypothesis and managing the risks of societal technology choices

International Nuclear Information System (INIS)

Cantor, R.; Rayner, S.

1986-08-01

Much of the literature on risk perception and management has asked how society should resolve the question, ''How safe is safe enough'' There has been political and technical disagreement over the types of answers that may be given, as well as over the social values attached to perceived probabilities and magnitudes of various outcomes. Despite controversy, there seems to have been a large measure of consensus that, ''How safe is safe enough'' is the right question to ask. This paper sets out to question that assumption. Various ingenious techniques of risk analysis have sought to discover the real risks inherent in various activities, but from a sociocultural viewpoint it can be seen that no single answer can be given to the problem of adequate safety in a complex society which contains a wide variety of perceptual biases about danger, expectations of the good life, and levels of demand for safety. The paper argues that, from a societal risk-management perspective, we should be addressing a different range of questions that views societal risk as a whole rather than as the sum of individual hazards. Resolving the question, ''How safe is safe enough'' is less important in making societal technology choices than ''How fair is safe enough?'' A recent empirical pilot study is reported which explored the fairness hypotheses in the context of nuclear power. The results indicate that the process of technology choice should recognize explicitly the preferred principles different parties hold with respect to obtaining consent from those affected by the risks, distributing the liabilities, and justifying trust in the relevant institutions. The paper closes with a discussion of future prospects for the fairness approach in areas such as noxious facility siting

Cultural Norms for Adult Corporal Punishment of Children and Societal Rates of Endorsement and Use of Violence.

Science.gov (United States)

Lansford, Jennifer E; Dodge, Kenneth A

2008-07-01

OBJECTIVE: To test the hypothesis that societal rates of corporal punishment of children predict societal levels of violence, using "culture" as the unit of analysis. DESIGN: Data were retrieved from the Standard Cross-Cultural Sample of anthropological records, which includes 186 cultural groups, to represent the world's 200 provinces based on diversity of language, economy, political organization, descent, and historical time. Independent coders rated the frequency and harshness of corporal punishment of children, inculcation of aggression in children, warfare, interpersonal violence among adults, and demographic, socioeconomic, and parenting covariates. RESULTS: More frequent use of corporal punishment was related to higher rates of inculcation of aggression in children, warfare, and interpersonal violence. These relations held for inculcation of aggression in children and warfare after controlling for demographic, socioeconomic, and parenting confounds. CONCLUSION: More frequent use of corporal punishment is related to higher prevalence of violence and endorsement of violence at a societal level. The findings are consistent with theories that adult violence becomes more prevalent in contexts in which corporal punishment is frequent, that the use of corporal punishment increases the probability that children will engage in violent behaviors during adulthood, and that violence in one social domain tends to influence behavior in other domains. If corporal punishment leads to higher levels of societal violence, then reducing parents' use of corporal punishment should lead to reductions in societal violence manifested in other ways.

Appropriate methodologies for assessing the societal cost and benefits of conservation programs

International Nuclear Information System (INIS)

Power, J.M.; Gill, G.S.; Harvey, K.M.

1983-01-01

The use of cost-benefit analysis for assessing the societal cost and benefits of conservation programmes is discussed. It is concluded that it should not be the sole criterion for project choice. (U.K.)

AlignNemo: a local network alignment method to integrate homology and topology.

Directory of Open Access Journals (Sweden)

Giovanni Ciriello

Full Text Available Local network alignment is an important component of the analysis of protein-protein interaction networks that may lead to the identification of evolutionary related complexes. We present AlignNemo, a new algorithm that, given the networks of two organisms, uncovers subnetworks of proteins that relate in biological function and topology of interactions. The discovered conserved subnetworks have a general topology and need not to correspond to specific interaction patterns, so that they more closely fit the models of functional complexes proposed in the literature. The algorithm is able to handle sparse interaction data with an expansion process that at each step explores the local topology of the networks beyond the proteins directly interacting with the current solution. To assess the performance of AlignNemo, we ran a series of benchmarks using statistical measures as well as biological knowledge. Based on reference datasets of protein complexes, AlignNemo shows better performance than other methods in terms of both precision and recall. We show our solutions to be biologically sound using the concept of semantic similarity applied to Gene Ontology vocabularies. The binaries of AlignNemo and supplementary details about the algorithms and the experiments are available at: sourceforge.net/p/alignnemo.

Novel real-time alignment and calibration of the LHCb detector in Run2

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00144085

2017-01-01

LHCb has introduced a novel real-time detector alignment and calibration strategy for LHC Run2. Data collected at the start of the fill are processed in a few minutes and used to update the alignment parameters, while the calibration constants are evaluated for each run. This procedure improves the quality of the online reconstruction. For example, the vertex locator is retracted and reinserted for stable beam conditions in each fill to be centred on the primary vertex position in the transverse plane. Consequently its position changes on a fill-by-fill basis. Critically, this new real-time alignment and calibration procedure allows identical constants to be used in the online and offline reconstruction, thus improving the correlation between triggered and offline-selected events. This offers the opportunity to optimise the event selection in the trigger by applying stronger constraints. The required computing time constraints are met thanks to a new dedicated framework using the multi-core farm infrastructur...

FMIT alignment cart

International Nuclear Information System (INIS)

Potter, R.C.; Dauelsberg, L.B.; Clark, D.C.; Grieggs, R.J.

1981-01-01

The Fusion Materials Irradiation Test (FMIT) Facility alignment cart must perform several functions. It must serve as a fixture to receive the drift-tube girder assembly when it is removed from the linac tank. It must transport the girder assembly from the linac vault to the area where alignment or disassembly is to take place. It must serve as a disassembly fixture to hold the girder while individual drift tubes are removed for repair. It must align the drift tube bores in a straight line parallel to the girder, using an optical system. These functions must be performed without violating any clearances found within the building. The bore tubes of the drift tubes will be irradiated, and shielding will be included in the system for easier maintenance

How firms talk about sustainability and the societal role of business

DEFF Research Database (Denmark)

Madsen, Erik Kloppenborg

2000-01-01

The aim of this paper is to study the language of sustainability in a business context. Based on information excerpted from two Scandinavian firm web sites a closer examination of reasoning and arguing concerning sustainability and the societal role of business is performed. The interpretation...

A fast fiducial marker tracking model for fully automatic alignment in electron tomography

KAUST Repository

Han, Renmin; Zhang, Fa; Gao, Xin

2017-01-01

Automatic alignment, especially fiducial marker-based alignment, has become increasingly important due to the high demand of subtomogram averaging and the rapid development of large-field electron microscopy. Among the alignment steps, fiducial marker tracking is a crucial one that determines the quality of the final alignment. Yet, it is still a challenging problem to track the fiducial markers accurately and effectively in a fully automatic manner.In this paper, we propose a robust and efficient scheme for fiducial marker tracking. Firstly, we theoretically prove the upper bound of the transformation deviation of aligning the positions of fiducial markers on two micrographs by affine transformation. Secondly, we design an automatic algorithm based on the Gaussian mixture model to accelerate the procedure of fiducial marker tracking. Thirdly, we propose a divide-and-conquer strategy against lens distortions to ensure the reliability of our scheme. To our knowledge, this is the first attempt that theoretically relates the projection model with the tracking model. The real-world experimental results further support our theoretical bound and demonstrate the effectiveness of our algorithm. This work facilitates the fully automatic tracking for datasets with a massive number of fiducial markers.The C/C ++ source code that implements the fast fiducial marker tracking is available at https://github.com/icthrm/gmm-marker-tracking. Markerauto 1.6 version or later (also integrated in the AuTom platform at http://ear.ict.ac.cn/) offers a complete implementation for fast alignment, in which fast fiducial marker tracking is available by the

A fast fiducial marker tracking model for fully automatic alignment in electron tomography

KAUST Repository

Han, Renmin

2017-10-20

Automatic alignment, especially fiducial marker-based alignment, has become increasingly important due to the high demand of subtomogram averaging and the rapid development of large-field electron microscopy. Among the alignment steps, fiducial marker tracking is a crucial one that determines the quality of the final alignment. Yet, it is still a challenging problem to track the fiducial markers accurately and effectively in a fully automatic manner.In this paper, we propose a robust and efficient scheme for fiducial marker tracking. Firstly, we theoretically prove the upper bound of the transformation deviation of aligning the positions of fiducial markers on two micrographs by affine transformation. Secondly, we design an automatic algorithm based on the Gaussian mixture model to accelerate the procedure of fiducial marker tracking. Thirdly, we propose a divide-and-conquer strategy against lens distortions to ensure the reliability of our scheme. To our knowledge, this is the first attempt that theoretically relates the projection model with the tracking model. The real-world experimental results further support our theoretical bound and demonstrate the effectiveness of our algorithm. This work facilitates the fully automatic tracking for datasets with a massive number of fiducial markers.The C/C ++ source code that implements the fast fiducial marker tracking is available at https://github.com/icthrm/gmm-marker-tracking. Markerauto 1.6 version or later (also integrated in the AuTom platform at http://ear.ict.ac.cn/) offers a complete implementation for fast alignment, in which fast fiducial marker tracking is available by the

Innovative and responsible governance of nanotechnology for societal development

International Nuclear Information System (INIS)

Roco, Mihail C.; Harthorn, Barbara; Guston, David; Shapira, Philip

2011-01-01

Governance of nanotechnology is essential for realizing economic growth and other societal benefits of the new technology, protecting public health and environment, and supporting global collaboration and progress. The article outlines governance principles and methods specific for this emerging field. Advances in the last 10 years, the current status and a vision for the next decade are presented based on an international study with input from over 35 countries.

Areva. 2007 figures economic, social, societal and environmental data

International Nuclear Information System (INIS)

2007-01-01

This document presents the 2007 economic, social, societal and environmental data of the Areva Group. Content: 1 - Improvement initiative: Continuous improvement, Innovation; 2 - Financial performance: 2007 results; 3 - Commitment to employees: Stakeholder relations, Health and safety, Radiation protection, Radiological impacts, Technological risks, Workforce, Workforce and training; 4 - Environment: Water, Energy, Gaseous releases, Liquid releases, Conventional waste, Radioactive waste; 5 - Reporting and performance indicators: Reporting methodology, Auditors' report, Social indicators, Environmental indicators

Areva 2006 figures - Economic, social, societal and environmental data

International Nuclear Information System (INIS)

2006-01-01

This document presents the 2006 economic, social, societal and environmental data of the Areva Group. Content: 1 - Improvement initiative: Continuous improvement, Innovation, stakeholder relations, local economic development, Financial performance; 2 - Commitment to employees: Health and safety, Radiation protection, Radiological impacts, Technological risks, employees and training; 3 - Environment: Water, Energy, Gaseous releases, Liquid releases, Conventional waste, Radioactive waste; 4 - Reporting and performance indicators: Reporting methodology, Auditors' report, Social indicators, Environmental indicators

Alignment method for parabolic trough solar concentrators

Science.gov (United States)

Diver, Richard B [Albuquerque, NM

2010-02-23

A Theoretical Overlay Photographic (TOP) alignment method uses the overlay of a theoretical projected image of a perfectly aligned concentrator on a photographic image of the concentrator to align the mirror facets of a parabolic trough solar concentrator. The alignment method is practical and straightforward, and inherently aligns the mirror facets to the receiver. When integrated with clinometer measurements for which gravity and mechanical drag effects have been accounted for and which are made in a manner and location consistent with the alignment method, all of the mirrors on a common drive can be aligned and optimized for any concentrator orientation.

The influence of world societal forces on social tolerance. A time comparative study of prejudices in 32 countries.

Science.gov (United States)

Hadler, Markus

2012-01-01

Societal variation in xenophobia, homophobia, and other prejudices is frequently explained by the economic background and political history of different countries. This article expands these explanations by considering the influence of world societal factors on individual attitudes. The empirical analysis is based on survey data collected within the World Value Survey and European Values Study framework between 1989 and 2010. Data are combined to a three-wave cross-sectional design including about 130,000 respondents from 32 countries. Results show that xenophobia and homophobia are influenced by the national political history, societal affluence, and the presence of international organizations. Global forces, however, are of particular importance for homophobia.

Probabilistic biological network alignment.

Science.gov (United States)

Todor, Andrei; Dobra, Alin; Kahveci, Tamer

2013-01-01

Interactions between molecules are probabilistic events. An interaction may or may not happen with some probability, depending on a variety of factors such as the size, abundance, or proximity of the interacting molecules. In this paper, we consider the problem of aligning two biological networks. Unlike existing methods, we allow one of the two networks to contain probabilistic interactions. Allowing interaction probabilities makes the alignment more biologically relevant at the expense of explosive growth in the number of alternative topologies that may arise from different subsets of interactions that take place. We develop a novel method that efficiently and precisely characterizes this massive search space. We represent the topological similarity between pairs of aligned molecules (i.e., proteins) with the help of random variables and compute their expected values. We validate our method showing that, without sacrificing the running time performance, it can produce novel alignments. Our results also demonstrate that our method identifies biologically meaningful mappings under a comprehensive set of criteria used in the literature as well as the statistical coherence measure that we developed to analyze the statistical significance of the similarity of the functions of the aligned protein pairs.

Alignment data streams for the ATLAS inner detector

International Nuclear Information System (INIS)

Pinto, B; Amorim, A; Pereira, P; Elsing, M; Hawkings, R; Schieck, J; Garcia, S; Schaffer, A; Ma, H; Anjos, A

2008-01-01

The ATLAS experiment uses a complex trigger strategy to be able to reduce the Event Filter rate output, down to a level that allows the storage and processing of these data. These concepts are described in the ATLAS Computing Model which embraces Grid paradigm. The output coming from the Event Filter consists of four main streams: physical stream, express stream, calibration stream, and diagnostic stream. The calibration stream will be transferred to the Tier-0 facilities that will provide the prompt reconstruction of this stream with a minimum latency of 8 hours, producing calibration constants of sufficient quality to allow a first-pass processing. The Inner Detector community is developing and testing an independent common calibration stream selected at the Event Filter after track reconstruction. It is composed of raw data, in byte-stream format, contained in Readout Buffers (ROBs) with hit information of the selected tracks, and it will be used to derive and update a set of calibration and alignment constants. This option was selected because it makes use of the Byte Stream Converter infrastructure and possibly gives better bandwidth usage and storage optimization. Processing is done using specialized algorithms running in the Athena framework in dedicated Tier-0 resources, and the alignment constants will be stored and distributed using the COOL conditions database infrastructure. This work is addressing in particular the alignment requirements, the needs for track and hit selection, and the performance issues

Alignment data stream for the ATLAS inner detector

International Nuclear Information System (INIS)

Pinto, B

2010-01-01

The ATLAS experiment uses a complex trigger strategy to be able to achieve the necessary Event Filter rate output, making possible to optimize the storage and processing needs of these data. These needs are described in the ATLAS Computing Model, which embraces Grid concepts. The output coming from the Event Filter will consist of three main streams: a primary stream, the express stream and the calibration stream. The calibration stream will be transferred to the Tier-0 facilities which will allow the prompt reconstruction of this stream with an admissible latency of 8 hours, producing calibration constants of sufficient quality to permit a first-pass processing. An independent calibration stream is developed and tested, which selects tracks at the level-2 trigger (LVL2) after the reconstruction. The stream is composed of raw data, in byte-stream format, and contains only information of the relevant parts of the detector, in particular the hit information of the selected tracks. This leads to a significantly improved bandwidth usage and storage capability. The stream will be used to derive and update the calibration and alignment constants if necessary every 24h. Processing is done using specialized algorithms running in Athena framework in dedicated Tier-0 resources, and the alignment constants will be stored and distributed using the COOL conditions database infrastructure. The work is addressing in particular the alignment requirements, the needs for track and hit selection, timing and bandwidth issues.

Hybrid vehicle motor alignment

Science.gov (United States)

Levin, Michael Benjamin

2001-07-03

A rotor of an electric motor for a motor vehicle is aligned to an axis of rotation for a crankshaft of an internal combustion engine having an internal combustion engine and an electric motor. A locator is provided on the crankshaft, a piloting tool is located radially by the first locator to the crankshaft. A stator of the electric motor is aligned to a second locator provided on the piloting tool. The stator is secured to the engine block. The rotor is aligned to the crankshaft and secured thereto.

Test procedure for calibration, grooming and alignment of the LDUA Optical Alignment Scope

International Nuclear Information System (INIS)

Potter, J.D.

1995-01-01

The Light Duty Utility Arm (LDUA) is a remotely operated manipulator used to enter into underground waste tanks through one of the tank risers. The LDUA must be carefully aligned with the tank riser during the installation process. The Optical Alignment Scope (OAS) is used to determine when optimum alignment has been achieved between the LDUA and the riser. This procedure is used to assure that the instrumentation and equipment comprising the OAS is properly adjusted in order to achieve its intended functions successfully

Reimbursed Price of Orphan Drugs: Current Strategies and Potential Improvements.

Science.gov (United States)

Mincarone, Pierpaolo; Leo, Carlo Giacomo; Sabina, Saverio; Sarriá-Santamera, Antonio; Taruscio, Domenica; Serrano-Aguilar, Pedro Guillermo; Kanavos, Panos

2017-01-01

The pricing and reimbursement policies for pharmaceuticals are relevant to balance timely and equitable access for all patients, financial sustainability, and reward for valuable innovation. The proliferation of high-cost specialty medicines is particularly true in rare diseases (RDs) where the pricing mechanism is characterised by a lack of transparency. This work provides an overall picture of current strategies for the definition of the reimbursed prices of orphan drugs (ODs) and highlights some potential improvements. Current strategies and suggestions are presented along 4 dimensions: (1) comprehensive value assessment, (2) early dialogs among relevant stakeholders, (3) innovative reimbursement approaches, and (4) societal participation in producing ODs. Comprehensive value assessment could be achieved by clarifying the approach of distributive justice to adopt, ensuring a representative participation of stakeholders, and with a broad consideration of value-bearing factors. With respect to early dialogs, cross-border cooperation can be determinant to companies and agencies. The cost-benefit ratio of early dialogs needs to be demonstrated and the "regulatory capture" effect should be monitored. Innovative reimbursement approaches were developed to balance the need for evidence-based decisions with the timely access to innovative drugs. The societal participation in producing ODs needs to be recognised in a collaborating framework where adaptive agreements can be developed with mutual satisfaction. Such agreements could also impact on coverage and reimbursement decisions as additional elements for the determination of a comprehensive societal value of ODs. Further research is needed to investigate the highlighted open challenges so that RDs will not remain, in practical terms, orphan diseases. © 2017 S. Karger AG, Basel.

SATe-II: very fast and accurate simultaneous estimation of multiple sequence alignments and phylogenetic trees.

Science.gov (United States)

Liu, Kevin; Warnow, Tandy J; Holder, Mark T; Nelesen, Serita M; Yu, Jiaye; Stamatakis, Alexandros P; Linder, C Randal

2012-01-01

Highly accurate estimation of phylogenetic trees for large data sets is difficult, in part because multiple sequence alignments must be accurate for phylogeny estimation methods to be accurate. Coestimation of alignments and trees has been attempted but currently only SATé estimates reasonably accurate trees and alignments for large data sets in practical time frames (Liu K., Raghavan S., Nelesen S., Linder C.R., Warnow T. 2009b. Rapid and accurate large-scale coestimation of sequence alignments and phylogenetic trees. Science. 324:1561-1564). Here, we present a modification to the original SATé algorithm that improves upon SATé (which we now call SATé-I) in terms of speed and of phylogenetic and alignment accuracy. SATé-II uses a different divide-and-conquer strategy than SATé-I and so produces smaller more closely related subsets than SATé-I; as a result, SATé-II produces more accurate alignments and trees, can analyze larger data sets, and runs more efficiently than SATé-I. Generally, SATé is a metamethod that takes an existing multiple sequence alignment method as an input parameter and boosts the quality of that alignment method. SATé-II-boosted alignment methods are significantly more accurate than their unboosted versions, and trees based upon these improved alignments are more accurate than trees based upon the original alignments. Because SATé-I used maximum likelihood (ML) methods that treat gaps as missing data to estimate trees and because we found a correlation between the quality of tree/alignment pairs and ML scores, we explored the degree to which SATé's performance depends on using ML with gaps treated as missing data to determine the best tree/alignment pair. We present two lines of evidence that using ML with gaps treated as missing data to optimize the alignment and tree produces very poor results. First, we show that the optimization problem where a set of unaligned DNA sequences is given and the output is the tree and alignment of

Maximising Benefit from Defence Research: A Review of Defence Research and Technology for Alignment, Quality and Exploitation

National Research Council Canada - National Science Library

2006-01-01

.... We announced in the Strategy that we had set in place an evidence-based peer review of research alignment, quality and exploitation, net as a one-off exercise, but to set a benchmark for future...

Forecasting Significant Societal Events Using The Embers Streaming Predictive Analytics System.

Science.gov (United States)

Doyle, Andy; Katz, Graham; Summers, Kristen; Ackermann, Chris; Zavorin, Ilya; Lim, Zunsik; Muthiah, Sathappan; Butler, Patrick; Self, Nathan; Zhao, Liang; Lu, Chang-Tien; Khandpur, Rupinder Paul; Fayed, Youssef; Ramakrishnan, Naren

2014-12-01

Developed under the Intelligence Advanced Research Project Activity Open Source Indicators program, Early Model Based Event Recognition using Surrogates (EMBERS) is a large-scale big data analytics system for forecasting significant societal events, such as civil unrest events on the basis of continuous, automated analysis of large volumes of publicly available data. It has been operational since November 2012 and delivers approximately 50 predictions each day for countries of Latin America. EMBERS is built on a streaming, scalable, loosely coupled, shared-nothing architecture using ZeroMQ as its messaging backbone and JSON as its wire data format. It is deployed on Amazon Web Services using an entirely automated deployment process. We describe the architecture of the system, some of the design tradeoffs encountered during development, and specifics of the machine learning models underlying EMBERS. We also present a detailed prospective evaluation of EMBERS in forecasting significant societal events in the past 2 years.

Modified alignment CGHs for aspheric surface test

Science.gov (United States)

Song, Jae-Bong; Yang, Ho-Soon; Rhee, Hyug-Gyo; Lee, Yun-Woo

2009-08-01

Computer Generated Holograms (CGH) for optical test are commonly consisted of one main pattern for testing aspheric surface and some alignment patterns for aligning the interferometer, CGH, and the test optics. To align the CGH plate and the test optics, we designed the alignment CGHs modified from the cat's eye alignment method, which are consisted of a couple of CGH patterns. The incident beam passed through the one part of the alignment CGH pattern is focused onto the one radius position of the test aspheric surface, and is reflected to the other part, and vice versa. This method has several merits compared to the conventional cat's eye alignment method. First, this method can be used in testing optics with a center hole, and the center part of CGH plate can be assigned to the alignment pattern. Second, the alignment pattern becomes a concentric circular arc pattern. The whole CGH patterns including the main pattern and alignment patterns are consisted of only concentric circular fringes. This concentric circular pattern can be easily made by the polar coordinated writer with circular scanning. The required diffraction angle becomes relatively small, so the 1st order diffraction beams instead of the 3rd order diffraction beam can be used as alignment beams, and the visibility can be improved. This alignment method also is more sensitive to the tilt and the lateral shift of the test aspheric surface. Using this alignment pattern, a 200 mm diameter F/0.5 aspheric mirror and a 600 mm diameter F/0.9 mirror were tested.

Improving societal acceptance of rad waste management policy decisions: an approach based on complex intelligence

International Nuclear Information System (INIS)

Rao, Suman

2008-01-01

In today's context elaborate public participation exercises are conducted around the world to elicit and incorporate societal risk perceptions into nuclear policy Decision-Making. However, on many occasions, such as in the case of rad waste management, the society remains unconvinced about these decisions. This naturally leads to the questions: are techniques for incorporating societal risk perceptions into the rad waste policy decision making processes sufficiently mature? How could societal risk perceptions and legal normative principles be better integrated in order to render the decisions more equitable and convincing to society? Based on guidance from socio-psychological research this paper postulates that a critical factor for gaining/improving societal acceptance is the quality and adequacy of criteria for option evaluation that are used in the policy decision making. After surveying three rad waste public participation cases, the paper identifies key lacunae in criteria abstraction processes as currently practiced. A new policy decision support model CIRDA: Complex Intelligent Risk Discourse Abstraction model that is based on the heuristic of Risk-Risk Analysis is proposed to overcome these lacunae. CIRDA's functionality of rad waste policy decision making is modelled as a policy decision-making Abstract Intelligent Agent and the agent program/abstraction mappings are presented. CIRDA is then applied to a live (U.K.) rad waste management case and the advantages of this method as compared to the Value Tree Method as practiced in the GB case are demonstrated. (author)

Aligned, isotropic and patterned carbon nanotube substrates that control the growth and alignment of Chinese hamster ovary cells

Energy Technology Data Exchange (ETDEWEB)

Abdullah, Che Azurahanim Che; Asanithi, Piyapong; Brunner, Eric W; Jurewicz, Izabela; Bo, Chiara; Sear, Richard P; Dalton, Alan B [Department of Physics and Surrey Materials Institute, University of Surrey, Guildford, Surrey GU2 7XH (United Kingdom); Azad, Chihye Lewis; Ovalle-Robles, Raquel; Fang Shaoli; Lima, Marcio D; Lepro, Xavier; Collins, Steve; Baughman, Ray H, E-mail: r.sear@surrey.ac.uk [Alan G MacDiarmid NanoTech Institute, The University of Texas at Dallas, Richardson, TX 75080-3021 (United States)

2011-05-20

Here we culture Chinese hamster ovary cells on isotropic, aligned and patterned substrates based on multiwall carbon nanotubes. The nanotubes provide the substrate with nanoscale topography. The cells adhere to and grow on all substrates, and on the aligned substrate, the cells align strongly with the axis of the bundles of the multiwall nanotubes. This control over cell alignment is required for tissue engineering; almost all tissues consist of oriented cells. The aligned substrates are made using straightforward physical chemistry techniques from forests of multiwall nanotubes; no lithography is required to make inexpensive large-scale substrates with highly aligned nanoscale grooves. Interestingly, although the cells strongly align with the nanoscale grooves, only a few also elongate along this axis: alignment of the cells does not require a pronounced change in morphology of the cell. We also pattern the nanotube bundles over length scales comparable to the cell size and show that the cells follow this pattern.

ChromAlign: A two-step algorithmic procedure for time alignment of three-dimensional LC-MS chromatographic surfaces.

Science.gov (United States)

Sadygov, Rovshan G; Maroto, Fernando Martin; Hühmer, Andreas F R

2006-12-15

We present an algorithmic approach to align three-dimensional chromatographic surfaces of LC-MS data of complex mixture samples. The approach consists of two steps. In the first step, we prealign chromatographic profiles: two-dimensional projections of chromatographic surfaces. This is accomplished by correlation analysis using fast Fourier transforms. In this step, a temporal offset that maximizes the overlap and dot product between two chromatographic profiles is determined. In the second step, the algorithm generates correlation matrix elements between full mass scans of the reference and sample chromatographic surfaces. The temporal offset from the first step indicates a range of the mass scans that are possibly correlated, then the correlation matrix is calculated only for these mass scans. The correlation matrix carries information on highly correlated scans, but it does not itself determine the scan or time alignment. Alignment is determined as a path in the correlation matrix that maximizes the sum of the correlation matrix elements. The computational complexity of the optimal path generation problem is reduced by the use of dynamic programming. The program produces time-aligned surfaces. The use of the temporal offset from the first step in the second step reduces the computation time for generating the correlation matrix and speeds up the process. The algorithm has been implemented in a program, ChromAlign, developed in C++ language for the .NET2 environment in WINDOWS XP. In this work, we demonstrate the applications of ChromAlign to alignment of LC-MS surfaces of several datasets: a mixture of known proteins, samples from digests of surface proteins of T-cells, and samples prepared from digests of cerebrospinal fluid. ChromAlign accurately aligns the LC-MS surfaces we studied. In these examples, we discuss various aspects of the alignment by ChromAlign, such as constant time axis shifts and warping of chromatographic surfaces.

Cost of illness of atrial fibrillation: a nationwide study of societal impact.

Science.gov (United States)

Johnsen, Søren Paaske; Dalby, Lene Worsaae; Täckström, Tomas; Olsen, Jens; Fraschke, Anina

2017-11-10

The prevalence of atrial fibrillation is increasing rapidly; however, to date, population-based data are lacking on the attributable cost of illness of atrial fibrillation from a societal perspective, including both direct and indirect costs. The study was an incidence-based cost-of-illness study based on national registries covering the entire population of Denmark. We identified all patients with a first-time hospital diagnosis of atrial fibrillation between 2001 and 2012. For every atrial fibrillation patient, we identified three age- and sex-matched controls from the general population. Both the total and the attributable costs of atrial fibrillation were estimated based on individual level information on hospital care (in- and out-patient contacts), primary sector care, use of prescription drugs and productivity loss. Average 3-year societal costs per patient attributable to atrial fibrillation were estimated to be €20,403-26,544 during the study period. The costs were highest during the first year after diagnosis of atrial fibrillation. Admission costs constituted the largest cost component, whereas primary sector costs and medicine costs only constituted minor components. The attributable costs were more than two-fold higher among patients experiencing a stroke. The total 3-year cost attributable to atrial fibrillation in Denmark was estimated to be €219-295 million. The societal costs attributable to atrial fibrillation are significant. Reducing the need for hospitalizations, in particular from stroke, is a key factor in controlling the costs.

Chromatic bifocus alignment system for SR stepper

International Nuclear Information System (INIS)

Miyatake, Tsutomu

1991-01-01

A new alignment system developed for synchrotron radiation (SR) X-ray stepper is described. The alignment system has three key elements as follows. The first is a chromatic bifocus optics which observe high contrast bright images of alignment marks printed on a mask and a wafer. The second is broad band light illumination to observe the wafer alignment mark images which is unaffected by resist film coated on a wafer. The third is a new correlation function which is used in measuring of displacement between a mask and a wafer. The alignment system has achieved alignment accuracy on the order of 0.01 μm. The experimental results of this alignment system are discussed in this paper. (author)

Evaluation of the Strategy Management Implementation in Project- Oriented Service Organizations

Directory of Open Access Journals (Sweden)

Abolfazl Sherafat

2014-02-01

Full Text Available Although developing strategic and operational plans is a difficult and complicated process, their successful implementation is much more difficult. Many organizations fail in the full implementation of their strategies. This is not due to the partial definition of strategies and organization‘s operational plan, but this is likely due to the lack of strong framework for creating alignment between employees and operational process and the organizational goals. To implement strategies effectively and to develop a comprehensive management system and to improve the performance, Robert Kaplan and David Norton introduced a modern management system which is Balanced ScoreCard. Likewise they introduced five main criteria: leadership, translation, alignment, every day process and ongoing process for a strategy oriented organization. This paper is intended to offer a systematic approach for measuring the effectiveness and efficiency of the strategic plan performance. For this study the questionnaire was distributed in a project- orientated service organization and after collection, by the use of statistical. Analysis especially factor analysis the grouping of sub-criteria under the five main criteria was confirmed. The statistical analysis showed that, two criteria of alignment and every day work had the lowest scores in terms of both implementation and effectiveness in the organization‘s senior and executive manager‘s point of view. With deep interview, studying of scorecards and meeting of the strategic committee of the studied organization, the two dimension of alignment and every day work were further examined and after identifying upgradeable areas, some suggestions for improving the effectiveness and efficiency of the studied organization were presented.

The timing and societal synchronisation of energy demand

OpenAIRE

Mattioli, G; Shove, E; Torriti, J

2014-01-01

It is increasingly important to know about when energy is used in the home, at work and on the move. Issues of time and timing have not featured strongly in energy policy analysis and in modelling, much of which has focused on estimating and reducing total average annual demand per capita. If smarter ways of balancing supply and demand are to take hold, and if we are to make better use of decarbonised forms of supply, it is essential to understand and intervene in patterns of societal synchro...

Comprehensive safeguards evaluation methods and societal risk analysis

International Nuclear Information System (INIS)

Richardson, J.M.

1982-03-01

Essential capabilities of an integrated evaluation methodology for analyzing safeguards systems are discussed. Such a methodology must be conceptually meaningful, technically defensible, discriminating and consistent. A decompostion of safeguards systems by function is mentioned as a possible starting point for methodology development. The application of a societal risk equation to safeguards systems analysis is addressed. Conceptual problems with this approach are discussed. Technical difficulties in applying this equation to safeguards systems are illustrated through the use of confidence intervals, information content, hypothesis testing and ranking and selection procedures

Tracing magnetic fields with aligned grains

International Nuclear Information System (INIS)

Lazarian, A.

2007-01-01

Magnetic fields play a crucial role in various astrophysical processes, including star formation, accretion of matter, transport processes (e.g., transport of heat), and cosmic rays. One of the easiest ways to determine the magnetic field direction is via polarization of radiation resulting from extinction or/and emission by aligned dust grains. Reliability of interpretation of the polarization maps in terms of magnetic fields depends on how well we understand the grain-alignment theory. Explaining what makes grains aligned has been one of the big issues of the modern astronomy. Numerous exciting physical effects have been discovered in the course of research undertaken in this field. As both the theory and observations matured, it became clear that the grain-alignment phenomenon is inherent not only in diffuse interstellar medium or molecular clouds but also is a generic property of the dust in circumstellar regions, interplanetary space and cometary comae. Currently the grain-alignment theory is a predictive one, and its results nicely match observations. Among its predictions is a subtle phenomenon of radiative torques. This phenomenon, after having stayed in oblivion for many years after its discovery, is currently viewed as the most powerful means of alignment. In this article, I shall review the basic physical processes involved in grain alignment, and the currently known mechanisms of alignment. I shall also discuss possible niches for different alignment mechanisms. I shall dwell on the importance of the concept of grain helicity for understanding of many properties of grain alignment, and shall demonstrate that rather arbitrarily shaped grains exhibit helicity when they interact with gaseous and radiative flows

DNAAlignEditor: DNA alignment editor tool

Directory of Open Access Journals (Sweden)

Guill Katherine E

2008-03-01

Full Text Available Abstract Background With advances in DNA re-sequencing methods and Next-Generation parallel sequencing approaches, there has been a large increase in genomic efforts to define and analyze the sequence variability present among individuals within a species. For very polymorphic species such as maize, this has lead to a need for intuitive, user-friendly software that aids the biologist, often with naïve programming capability, in tracking, editing, displaying, and exporting multiple individual sequence alignments. To fill this need we have developed a novel DNA alignment editor. Results We have generated a nucleotide sequence alignment editor (DNAAlignEditor that provides an intuitive, user-friendly interface for manual editing of multiple sequence alignments with functions for input, editing, and output of sequence alignments. The color-coding of nucleotide identity and the display of associated quality score aids in the manual alignment editing process. DNAAlignEditor works as a client/server tool having two main components: a relational database that collects the processed alignments and a user interface connected to database through universal data access connectivity drivers. DNAAlignEditor can be used either as a stand-alone application or as a network application with multiple users concurrently connected. Conclusion We anticipate that this software will be of general interest to biologists and population genetics in editing DNA sequence alignments and analyzing natural sequence variation regardless of species, and will be particularly useful for manual alignment editing of sequences in species with high levels of polymorphism.

A Cross-Cultural Study of Gifted Students' Scientific, Societal, and Moral Questions Concerning Science

Directory of Open Access Journals (Sweden)

Kirsi Tirri

2012-01-01

Full Text Available This study investigated the number and nature of gifted female and male students' scientific, societal, and moral questions concerning science. The participants (=658 of this study were 16–19-year-old international students from 55 countries and two continents, Asia and Europe. They applied to participate in the Millennium Youth Camp held in 2011 in Finland. The students came from scientifically and mathematically oriented schools, and they had shown an interest towards science through competitions, school success, and their own research. The students were asked to formulate questions they would like to get answers to during the camp. The nature and number of the students' questions were analyzed with qualitative and quantitative content analysis. The results showed that the boys asked more scientific questions than the girls, and the girls asked more societal questions than the boys. The students asked less questions about morality than scientific or societal questions. The most common questions about morality were related to pollution and fresh air, environmental problems, and water protection. The results point to the need for teachers to teach socioscientific issues and discuss moral questions related to science.

MEMS Integrated Submount Alignment for Optoelectronics

Science.gov (United States)

Shakespeare, W. Jeffrey; Pearson, Raymond A.; Grenestedt, Joachim L.; Hutapea, Parsaoran; Gupta, Vikas

2005-02-01

One of the most expensive and time-consuming production processes for single-mode fiber-optic components is the alignment of the photonic chip or waveguide to the fiber. The alignment equipment is capital intensive and usually requires trained technicians to achieve desired results. Current technology requires active alignment since tolerances are only ~0.2 μ m or less for a typical laser diode. This is accomplished using piezoelectric actuated stages and active optical feedback. Joining technologies such as soldering, epoxy bonding, or laser welding may contribute significant postbond shift, and final coupling efficiencies are often less than 80%. This paper presents a method of adaptive optical alignment to freeze in place directly on an optical submount using a microelectromechanical system (MEMS) shape memory alloy (SMA) actuation technology. Postbond shift is eliminated since the phase change is the alignment actuation. This technology is not limited to optical alignment but can be applied to a variety of MEMS actuations, including nano-actuation and nano-alignment for biomedical applications. Experimental proof-of-concept results are discussed, and a simple analytical model is proposed to predict the stress strain behavior of the optical submount. Optical coupling efficiencies and alignment times are compared with traditional processes. The feasibility of this technique in high-volume production is discussed.

Applications and societal benefits of plastics.

Science.gov (United States)

Andrady, Anthony L; Neal, Mike A

2009-07-27

This article explains the history, from 1600 BC to 2008, of materials that are today termed 'plastics'. It includes production volumes and current consumption patterns of five main commodity plastics: polypropylene, polyethylene, polyvinyl chloride, polystyrene and polyethylene terephthalate. The use of additives to modify the properties of these plastics and any associated safety, in use, issues for the resulting polymeric materials are described. A comparison is made with the thermal and barrier properties of other materials to demonstrate the versatility of plastics. Societal benefits for health, safety, energy saving and material conservation are described, and the particular advantages of plastics in society are outlined. Concerns relating to littering and trends in recycling of plastics are also described. Finally, we give predictions for some of the potential applications of plastic over the next 20 years.

How do young people in Cambodia perceive the impact of societal attitudes, media and religion on suicidal behaviour?

Science.gov (United States)

Jegannathan, Bhoomikumar; Kullgren, Gunnar; Dahlblom, Kjerstin

2016-03-01

Young people in low and middle income countries (LMICs) in societal transitions with rapidly changing norms face an increased risk of suicide. This study explores how young people in Cambodia understand the impact on suicidal behaviour from societal attitudes, media and religion. Focus group discussions were held with school students from a suburban area. Thematic analysis was used to interpret the data. Participants perceived the prevailing suicide-stigmatizing societal attitudes, the double-edged media and suicide-ambiguity in Buddhist religion as challenging. Globalization was recognized as contradicting with traditional Cambodian norms and values. Suicide prevention programmes should take into consideration the complex picture of suicide that young people are exposed to. © The Author(s) 2015.

Human choice and climate change. Volume 1: The societal framework

International Nuclear Information System (INIS)

Raynor, S.; Malone, E.

1998-01-01

This book is Volume 1 of a four-volume set which assesses social science research that is relevant to global climate change from a wide-ranging interdisciplinary perspective. Attention is focused on the societal framework as it relates to climate change. This series is indispensable reading for scientists and engineers wishing to make an effective contribution to the climate change policy debate

A cross-species alignment tool (CAT)

DEFF Research Database (Denmark)

Li, Heng; Guan, Liang; Liu, Tao

2007-01-01

BACKGROUND: The main two sorts of automatic gene annotation frameworks are ab initio and alignment-based, the latter splitting into two sub-groups. The first group is used for intra-species alignments, among which are successful ones with high specificity and speed. The other group contains more...... sensitive methods which are usually applied in aligning inter-species sequences. RESULTS: Here we present a new algorithm called CAT (for Cross-species Alignment Tool). It is designed to align mRNA sequences to mammalian-sized genomes. CAT is implemented using C scripts and is freely available on the web...... at http://xat.sourceforge.net/. CONCLUSIONS: Examined from different angles, CAT outperforms other extant alignment tools. Tested against all available mouse-human and zebrafish-human orthologs, we demonstrate that CAT combines the specificity and speed of the best intra-species algorithms, like BLAT...

Methods in ALFA Alignment

CERN Document Server

Melendez, Jordan

2014-01-01

This note presents two model-independent methods for use in the alignment of the ALFA forward detectors. Using a Monte Carlo simulated LHC run at \\beta = 90m and \\sqrt{s} = 7 TeV, the Kinematic Peak alignment method is utilized to reconstruct the Mandelstam momentum transfer variable t for single-diractive protons. The Hot Spot method uses fluctuations in the hitmap density to pinpoint particular regions in the detector that could signal a misalignment. Another method uses an error function fit to find the detector edge. With this information, the vertical alignment can be determined.

Multiple Whole Genome Alignments Without a Reference Organism

Energy Technology Data Exchange (ETDEWEB)

Dubchak, Inna; Poliakov, Alexander; Kislyuk, Andrey; Brudno, Michael

2009-01-16

Multiple sequence alignments have become one of the most commonly used resources in genomics research. Most algorithms for multiple alignment of whole genomes rely either on a reference genome, against which all of the other sequences are laid out, or require a one-to-one mapping between the nucleotides of the genomes, preventing the alignment of recently duplicated regions. Both approaches have drawbacks for whole-genome comparisons. In this paper we present a novel symmetric alignment algorithm. The resulting alignments not only represent all of the genomes equally well, but also include all relevant duplications that occurred since the divergence from the last common ancestor. Our algorithm, implemented as a part of the VISTA Genome Pipeline (VGP), was used to align seven vertebrate and sixDrosophila genomes. The resulting whole-genome alignments demonstrate a higher sensitivity and specificity than the pairwise alignments previously available through the VGP and have higher exon alignment accuracy than comparable public whole-genome alignments. Of the multiple alignment methods tested, ours performed the best at aligning genes from multigene families?perhaps the most challenging test for whole-genome alignments. Our whole-genome multiple alignments are available through the VISTA Browser at http://genome.lbl.gov/vista/index.shtml.

Alignment system for SGII-Up laser facility

Science.gov (United States)

Gao, Yanqi; Cui, Yong; Li, Hong; Gong, Lei; Lin, Qiang; Liu, Daizhong; Zhu, Baoqiang; Ma, Weixin; Zhu, Jian; Lin, Zunqi

2018-03-01

The SGII-Up laser facility in Shanghai is one of the most important high-power laser facilities in China. It is designed to obtain 24 kJ (3ω) of energy with a square pulse of 3 ns using eight laser beams (two bundles). To satisfy the requirements for the safety, efficiency, and quality, an alignment system is developed for this facility. This alignment system can perform automatic alignment of the preamplifier system, main amplifier system, and harmonic conversion system within 30 min before every shot during the routine operation of the facility. In this article, an overview of the alignment system is first presented. Then, its alignment characteristics are discussed, along with the alignment process. Finally, experimental results, including the alignment results and the facility performance, are reported. The results show that the far-field beam pointing alignment accuracy is better than 3 μrad, and the alignment error of the near-field beam centering is no larger than 1 mm. These satisfy the design requirements very well.

Stakeholder involvement in CSR strategy-making?

DEFF Research Database (Denmark)

Trapp, Leila

2014-01-01

A given characteristic of successful corporate social responsibility (CSR) programs is that they reflect stakeholder expectations and preferences for corporate behavior. This study examines the process by which this alignment is sought by CSR managers in the CSR strategy-making process. Through...... listening to others in the strategy-making process rather than directly involving others in decision-making. Also, because non-stakeholders, such as paid-for consultants, are found to be note-worthy influencers in the CSR strategy-making process, it is concluded that the process is not only a stakeholder...

Post-merger IT integration strategies: An IT alignment perspective

NARCIS (Netherlands)

Wijnhoven, Alphonsus B.J.M.; Spil, Antonius A.M.; Stegwee, R.A.; Fa, Rachel Tjang A

2006-01-01

When a company decides to merge with or to acquire another company, a major question is to what extent to integrate the information technologies and the organization. Interpreting merger objectives to proper IT integration strategies is a complex and time-consuming process, due to a lack of explicit

Novel Real-time Alignment and Calibration of the LHCb detector in Run2

Science.gov (United States)

Martinelli, Maurizio; LHCb Collaboration

2017-10-01

LHCb has introduced a novel real-time detector alignment and calibration strategy for LHC Run2. Data collected at the start of the fill are processed in a few minutes and used to update the alignment parameters, while the calibration constants are evaluated for each run. This procedure improves the quality of the online reconstruction. For example, the vertex locator is retracted and reinserted for stable beam conditions in each fill to be centred on the primary vertex position in the transverse plane. Consequently its position changes on a fill-by-fill basis. Critically, this new real-time alignment and calibration procedure allows identical constants to be used in the online and offline reconstruction, thus improving the correlation between triggered and offline-selected events. This offers the opportunity to optimise the event selection in the trigger by applying stronger constraints. The required computing time constraints are met thanks to a new dedicated framework using the multi-core farm infrastructure for the trigger. The motivation for a real-time alignment and calibration of the LHCb detector is discussed from both the operational and physics performance points of view. Specific challenges of this novel configuration are discussed, as well as the working procedures of the framework and its performance.

Awareness of Societal Issues among High School Biology Teachers Teaching Genetics

Science.gov (United States)

Lazarowitz, Reuven; Bloch, Ilit

2005-01-01

The purpose of this study was to investigate how aware high school biology teachers are of societal issues (values, moral, ethic, and legal issues) while teaching genetics, genetics engineering, molecular genetics, human heredity, and evolution. The study includes a short historical review of World War II atrocities during the Holocaust when…

Biaxial magnetic grain alignment

International Nuclear Information System (INIS)

Staines, M.; Genoud, J.-Y.; Mawdsley, A.; Manojlovic, V.

2000-01-01

Full text: We describe a dynamic magnetic grain alignment technique which can be used to produce YBCO thick films with a high degree of biaxial texture. The technique is, however, generally applicable to preparing ceramics or composite materials from granular materials with orthorhombic or lower crystal symmetry and is therefore not restricted to superconducting applications. Because magnetic alignment is a bulk effect, textured substrates are not required, unlike epitaxial coated tape processes such as RABiTS. We have used the technique to produce thick films of Y-247 on untextured silver substrates. After processing to Y-123 the films show a clear enhancement of critical current density relative to identically prepared untextured or uniaxially textured samples. We describe procedures for preparing materials using magnetic biaxial grain alignment with the emphasis on alignment in epoxy, which can give extremely high texture. X-ray rocking curves with FWHM of as little as 1-2 degrees have been measured

Conditions for developing a successful Talent Management Strategy